Diapositiva 1

Mid Term Event – 23 Oct 2013
Panel Discussion – Global Trends in Heathcare and local behaviours
MBC - MOLECULAR BIOTECHNOLOGY CENTER
UNIVERSITY OF TURIN - Overview
University of Turin was founded
in 1404
 7 University Schools
 3 Centers of Excellence
 27 University Departments
 70.000 students
 1.800 PhD
 4.000 Professors, Researchers
and staff personnel
SUISM
SUISM
Informatica
Psicologia,
Giurisprudenza,
Lettere e Filosofia,
Lingue e Lett. Straniere,
Scienze Politiche,
Scienze della Formazione
SUISS
….
Agraria,
Veterinaria
Biotecnologie
Medicina e Chirurgia
"S.Luigi Gonzaga"
Economia
Farmacia,
Scianze MFN
Medicina e Chirurgia
 Incubator
SAA
 Technology Transfer Office 
120 Patents (yrs 1999-2013)
Scienze MFN
MBC - MOLECULAR BIOTECHNOLOGY CENTER
Overview
Coupled with Interfaculty Biotechnology School
Launched in September 2006
More of 200 scientists
5 main Scientific Area of Interest:
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Inflammatory diseases
Oncogenesis and tumor immunology
Cardiac Hypertrophy in heart failure
Stem cells
Bioinformatics
Main activities:
 Animal House for Mice (10.000) and Rabbits (15)
 Generation of Transgenic and Knockout Mice
 Production and purification of recombinant proteins in
Prokaryotes and Eukaryotes
 Production and characterization of monoclonal and
polyclonal antibodies
MBC - MOLECULAR BIOTECHNOLOGY CENTER
Research streams
Stem Cells
Tumour Immunology
Molecular Imaging
Cardiovascular
Oncogenesis
Inflammation
Bioinformatics
MBC - MOLECULAR BIOTECHNOLOGY CENTER
Staff Scientists
Silvio AIME
Fiorella ALTRUDA
Laura BARBERIS
Mara BRANCACCIO
Benedetta BUSSOLATI
Sara CABODI
Enzo CALAUTTI
Giovanni CAMUSSI
Federica CAVALLO
Paola DEFILIPPI
Ferdinando DI CUNTO
Guido FORNI
Mario GIACOBINI
Jorg HAMM
Emilio HIRSCH
Valeria POLI
Paolo PROVERO
Francesco RETTA
Lorenzo SILENGO
Guido TARONE
Enzo TERRENO
Emanuela TOLOSANO
Emilia TURCO
Full Prof. of General Chemistry
Full Prof. of Molecular Genetics
Research Scientist of Molecular Biology
Research Scientist of Cell Biology
Associated Prof. of Pharmacology
Research Scientist of Cell Biology
Telethon Scientist
Full Prof. of Nephrology
Associated Prof. of Immunology
Full Prof. of Cell Biology
Associated Prof. of Molecular Biology
Full Prof. of Immunology
Research Scientist of Informatics
Lagrange Fellow
Full Prof. of Molecular Genetics
Full Prof. of Molecular Biology
Research Scientist of Bioinformatics
Associated Prof. of Cell Biology
Full Prof. of Molecular Biology
Full Prof. of Cell Biology
Associated Prof. of General Chemistry
Associated Prof. of Molecular Genetics
Associated Prof. of Genetics
Center of Excellence
of Molecular Imaging
Center for in vivo
Functional Genomics
Incubator of Ideas
MBC - MOLECULAR BIOTECHNOLOGY CENTER
Research Grants and Contracts
RESEARCH GRANTS
Funding from:
 European Community
 Italian Association for Cancer Research (AIRC)
 Telethon for Genetic Diseases
 Human Frontieres Science Project
 FIRB (Italian Ministry of University and Research)
 PRIN (Italian Ministry of University and Research)
 Italian Ministry of Health.
RESEARCH CONTRACTS WITH INDUSTRY
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Bracco
Serono
Glaxo SmithKline
Fresenius
BiPCa
RiboVax Bitechnologies
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NiCox Research Institute
CureTech
IrX Therapuetics
Agennix Inc
Nanogen
Bioline
Foundation CLINICAL INDUSTRIAL RESEARCH PARK
Foundation Clinical Industrial
Research Park
was founded to promote the technological transfer of
know-how and the results acquired
in academic research activities in Medicine,
Biomedical Engineering and Bio-Engineering fields.
FOUNDERS:
MBC - MOLECULAR BIOTECHNOLOGY CENTER
Ongoing Projects – 1/2
BIOTECHNOLOGY INCUBATOR
 A new project to extend facilities
 This will be one of the pillar of the knowledge-based next generation hospital, were customized
medicine meets patients needs.
The new building will host:
 Inter-academy department by UNITO and POLITO
 Large scale facility in Magnetic Resonance
 Start ups
 Joint labs accademy – industry
Rendering of new building.
Research streams:
 Regenerative Medicine
 Metabolic-cardiovascular platform
 20.000sqm hosting equipped labs and scientific instruments
 Work in progress to build 10.000sqm by 31-Dec-2015
MBC - MOLECULAR BIOTECHNOLOGY CENTER
Ongoing Projects – 2/2
Where the building will be located.
Section.
Planimetry of new building.
3D view.
 Financial support of Regione Piemonte and Compagnia di San Paolo
 Contributors:
Thank you for the attention
BACK UP
PUBLICATIONS by SCIENTIFIC AREA OF INTEREST
1/2
ONCOGENESIS AND TUMOR IMMUNOLOGY
CARDIAC HYPERTROPHY IN HEART FAILURE
B. Bussolati, S. Cabodi, G. Camussi, F. Cavallo, P. Defilippi, G. Forni, V.
Poli, F. Retta.
L. Barberis, M. Brancaccio, E. Hirsch and G. Tarone
Buttiglieri S, Deregibus MC, Bravo S, Cassoni P, Chiarle R, Bussolati B,
Camussi G. Role of Pax2 in apoptosis resistance and proinvasive
phenotype of Kaposi's sarcoma cells.
J Biol Chem. 2004; 279: 4136-43.
Bussolati B, Deambrosis I, Russo S, Deregibus MC, Camussi G. Altered
angiogenesis and survival in human tumor-derived endothelial cells.
FASEB J. 2003; 17: 1159-61.
Cabodi S, Tinnirello A, Di Stefano P, Bisaro B, Ambrosino E, Castellano I,
Sapino A, Arisio R, Cavallo F, Forni G, Glukhova M, Silengo L, Altruda F,
Turco E, Tarone G, Defilippi P. p130Cas as a new regulator of mammary
epithelial cell proliferation, survival, and HER2-neu oncogenedependent breast tumorigenesis.
Cancer Res. 2006; 66: 4672-80
Defilippi P, Di Stefano P, Cabodi S. p130Cas: a versatile scaffold in
signaling networks.
Trends Cell Biol. 2006; 16: 257-63
Nanni P, Nicoletti G, De Giovanni C, Landuzzi L, Di Carlo E, Cavallo F, Pupa
SM, Rossi I, Colombo MP, Ricci C, Astolfi A, Musiani P, Forni G, Lollini PL.
Combined allogeneic tumor cell vaccination and systemic interleukin
12 prevents mammary carcinogenesis in HER-2/neu transgenic mice.
J Exp Med. 2001; 194: 1195-205.
Lollini PL, Cavallo F, Nanni P, Forni G. Vaccines for tumour prevention.
Nat Rev Cancer. 2006; 6: 204-16.
Brancaccio M, Fratta L, Notte A, Hirsch E, Poulet R, Guazzone S, De Acetis
M, Vecchione C, Marino G, Altruda F, Silengo L, Tarone G, Lembo G.
Melusin, a muscle-specific integrin beta1-interacting protein, is
required to prevent cardiac failure in response to chronic pressure
overload.
Nat Med. 2003;9: 68-75
Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E,
Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G,
Fratta L, Oliveira-dos-Santos AJ, Benovic JL, Kahn CR, Izumo S, Steinberg
SF, Wymann MP, Backx PH, Penninger JM. Regulation of myocardial
contractility and cell size by distinct PI3K-PTEN signaling pathways.
Cell. 2002; 110: 737-49.
Patrucco E, Notte A, Barberis L, Selvetella G, Maffei A, Brancaccio M,
Marengo S, Russo G, Azzolino O, Rybalkin SD, Silengo L, Altruda F,
Wetzker R, Wymann MP, Lembo G, Hirsch E. PI3Kgamma modulates the
cardiac response to chronic pressure overload by distinct kinasedependent and -independent effects.
Cell. 2004; 118: 375-87.
PUBLICATIONS by SCIENTIFIC AREA OF INTEREST
2/2
STEM CELLS
BIOINFORMATICS
B. Bussolati, E. Calautti, G. Camussi, and F. Di Cunto
F. Di Cunto, P. Provero and L. Silengo
Herrera MB, Bruno S, Buttiglieri S, Tetta C, Gatti S, Deregibus MC, Bussolati
B, Camussi G. Isolation and characterization of a stem cell population
from adult human liver.
Stem Cells. 2006 Aug 31
Pellegrino M, Provero P, Silengo L, Di Cunto F. CLOE: identification of
putative functional relationships among genes by comparison of
expression profiles between two species.
BMC Bioinformatics. 2004; 5: 179.
Bussolati B, Bruno S, Grange C, Buttiglieri S, Deregibus MC, Cantino D,
Camussi G. Isolation of renal progenitor cells from adult human kidney.
Am J Pathol. 2005; 166: 545-55.
Cora D, Herrmann C, Dieterich C, Di Cunto F, Provero P, Caselle M. Ab
initio identification of putative human transcription factor binding sites
by comparative genomics.
BMC Bioinformatics. 2005 May 2;6:110.
Calautti E, Li J, Saoncella S, Brissette JL, Goetinck PF. Phosphoinositide
3-kinase signaling to Akt promotes keratinocyte differentiation versus
death.
J Biol Chem. 2005; 280: 32856-65.
Camera P, da Silva JS, Griffiths G, Giuffrida MG, Ferrara L, Schubert V,
Imarisio S, Silengo L, Dotti CG, Di Cunto F. Citron-N is a neuronal Rhoassociated protein involved in Golgi organization through actin
cytoskeleton regulation.
Nat Cell Biol. 2003; 5: 1071-8.