Sore throat - iNova Pharmaceuticals

Sore throat
Infection
Infection is an illness that is caused by germs or micro-organisms (tiny organisms) that invade the
body. Micro-organisms include the like of viruses, bacteria and fungi.1
Bacteria:
Viruses:
Fungi:
Normally the immune system protects the body from infection with the result that invading
microbes or micro-organisms are destroyed before they can multiply in sufficient numbers to
cause disease.1
Throat infections
Pharyngitis: 2
Tonsillitis: 2
Pharyngitis is an inflammation of the throat or pharynx that
is usually caused by a virus but is also commonly caused by
bacteria.
Tonsillitis is an inflammation of the tonsils that
occurs as a result of infection.
Symptoms :
Treatment:
Symptoms :
• Sore throat
• Anti-inflammatory
analgesics
• Swollen, bloodshot tonsils
• Throat lozenges,
throat gargles
• Difficulty in swallowing
• Discomfort when swallowing
• Earache
• Fever
• Enlarged lymph nodes in the neck
• Antibiotics if
bacterial infection
is suspected
• Sore throat
Treatment:
Treatment is the same
as for pharyngitis
• Earache
• Fever
• Headache
• Tender lymph nodes in
the neck
• Bad breath
sore
throat
Streptococcal throat: 3
Strep. throat is an infection of the pharynx or tonsils
caused by a type of bacteria called Streptococcus
pyogenes .
Symptoms include:
• Sore throat without runny nose or congestion
(these symptoms are more likely to occur with viral pharyngitis)
Laryngitis 2
Laryngitis is an
inflammation of the
larynx or voice box
that may be acute
lasting only a few
days or chronic,
where it persists
for a long time.
• White patches on the tonsils
Normal
vocal cords
Inflamed
vocal cords
Vocal cords
• Swollen lymph nodes in the neck
Symptoms :
• Fever with temperature greater than 38 °C
• Unnatural change of voice, hoarseness or loss of voice
• Throat pain or discomfort
• Dry irritating cough
• Laryngitis that occurs as a result of a viral infection is often accompanied by fever and a general feeling of illness
Sore
throats
Tonsillitis
infection
streptococcal
laryngitis
paininflammation
Treatment:
• Resting the voice
• Antibiotic if caused by bacteria
• Throat lozenges or gargle if sore throat
present
• Anti-inflammatory analgesic
Management of sore throat
Pain relief is the primary factor that a customer or patient with a sore throat seeks help for.
Benzydamine
• A nti-inflammatory agent with analgesic properties
• Benzydamine is a local anti-inflammatory painkiller4,5
• Benzydamine reduces prostaglandin synthesis5
• A naesthetic activity 6
• Rapidly and effectively anaesthetizes the oral cavity for at least 90 minutes
Sore
throats
Tonsillitis
infection
streptococcal
laryngitis
paininflammation
Pain relief
Benzydamine
• Anti-inflammatory agent with analgesic properties
• Benzydamine is a local anti-inflammatory painkiller4,5
• Benzydamine reduces prostaglandin synthesis5
• Anaesthetic activity 6
• Rapidly and effectively anaesthetizes the oral cavity for at least 90 minutes
• Analgesic
Andolex contains benzydamine, helps reduce swelling and pain
caused by inflammation 4,5
Antiseptic agents
Definition: 7
An antiseptic is an agent that inhibits the growth of micro-organisms such as viruses, bacteria
and fungi. Antiseptics like chlorhexidine gluconate and cetylpyridinium chloride are added to
some throat products.
Andolex-C for pain relief associated with minor oral infections
Andolex-C contains: chlorhexidine gluconate, has antiseptic and disinfectant properties and
helps reduce the development of plaque.
Andolex-C Gel and Lozenges contain: cetylpyridinium chloride as a quarternary pyridinium
antiseptic with bactericidal and fungicidal activity.
References: 1. Henry JA. British Medical Association New Guide to Medicines & Drugs 7th ed. London(UK) Dorling Kindersley;2007; p. 80-81128-9. 2. Peters M. British Medical Association A-Z Family Medical Encyclopedia 5th ed. London(UK):Dorling Kindersley;2008; p. 343,458-9, 604,664, 751. 3. Barclay L. Management of Streptococcal Pharyngitis Reviewed Medscape Medical News
March 2009 . Available from URL: http://www.medscape.com/viewarticle/589404 (Accessed 23.6.2011). 4. Quane PA et al. Pharmacology of benzydamine.Inflammopharmacology 1998;6:95-107. 5. Modeer T et al. Benzydamine reduces prostaglandin production in human gingival fibroblasts challenged with interleukin-1 beta or tumor necrosis factor alpha. Acta Odontol Scand 1999
Feb;57(1):40-5. 6. Simard-Savoie S et al. Topical anaesthetic activity of benzydamine. Curr Ther Res 1978;23(6);734-745. 7. Farlex. Antiseptic. The Free Dictionary Available from URL: http://www.thefreedictionary.com/p/Antiseptics (Accessed 23.6.2011). 8. Nguyen DH, et al. Common Dental Infections in the Primary Care Setting. Am fam Physician. 2008;77(5):797-802.
Scheduling status: S1 Proprietary name (and dosage form): ANDOLEX-C Oral Rinse Composition: Each 15 ml contains: Benzydamine HCl 22.5 mg, Chlorhexidine gluconate 18 mg, Alcohol 9% v/v. Registration number: 31/16.4/0143 [Act 101/1965]. Scheduling status: S1 Proprietary name (and dosage form): ANDOLEX-C LOZENGES HONEY
LEMON Composition: Each lozenge contains: Benzydamine HCl 3.00 mg, Cetylpyridinium chloride 1.33 mg Registration number: 35/16.4/0320 [Act 101/1965]. S1 Proprietary name (and dosage form): ANDOLEX-C LOZENGES ORANGE Composition: Each lozenge contains: Benzydamine HCl 3.00 mg, Cetylpyridinium chloride 1.33 mg Registration
number: 36/16.4/0195 [Act 101/1965]. S1 Proprietary name (and dosage form): ANDOLEX-C LOZENGES EUCALYPTUS MENTHOL Composition: Each lozenge contains: Benzydamine HCl 3.00 mg, Cetylpyridinium chloride 1.33 mg Registration number: 33/16.4/0374 [Act 101/1965]. S1 Proprietary name (and dosage form): ANDOLEX-C LOZENGES
Composition: Each lozenge contains: Benzydamine HCl 3.00 mg, Cetylpyridinium chloride 1.33 mg Registration number: 31/16.4/0042 [Act 101/1965]. S1 Proprietary name (and dosage form): ANDOLEX LOZENGES Composition: Each lozenge contains: Benzydamine HCl 3.00 mg Registration number: 31/16/0239 (Act 101/1965) Scheduling status:
S1 Proprietary name (and dosage form): ANDOLEX Solution Composition: Each 15 ml contains: Benzydamine HCl 22.5 mg. Preservative: Methyl hydroxybenzoate 0.1%m/v. Contains alcohol 10% v/v. Registration number: Z/16/40 [Act 101/1965]. Scheduling status: S1 Proprietary name (and dosage form): ANDOLEX-C ORAL GEL Composition:
Benzydamine HCl 10 mg/g, Cetylpyridinium chloride 1 mg/g. Registration number: 33/16.4/0285 (Act 101/1965) H516 (Act 101/1965).
Name and business address of applicant: iNova Pharmaceuticals (Pty) Ltd. Co. Reg. No. 1952/001640/07, 15e Riley Road, Bedfordview Tel.: +27 11 021 4155.www.inovapharma.co.za. For full prescribing information, refer to the package insert. Further information is available on request from iNova Pharmaceuticals. IN543/11