ACT Health Research Review 2013-2014

Transcription

ACT Health Research Review
2013 & 2014
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www.health.act.gov.au | www.act.gov.au
Enquiries: Canberra 13ACT1 or 132281 | Publication No 16/0340
1
2013 & 2014
3
Contents
Glossary4
Minister for Health5
ACT Health6
Director of Research 7
ACT Health Research Office
8
ACT Health Human Research Ethics Committee
10
Research Meetings 2013–2014
12
Canberra Health Annual Research Meeting – CHARM 2013
12
Canberra Health Annual Research Meeting – CHARM 2014
13
Research17
Academic Unit of General Practice
18
Academic Unit of Internal Medicine
20
Academic Unit of Ophthalmology
22
Acute Support Physiotherapy
23
Academic Unit of Psychiatry and Addiction Medicine
25
Anatomical Pathology
29
Canberra Sexual Health Centre
31
Cancer Immunology
33
Capital Region Retrieval Service
34
Cardiac Rehabilitation
35
Centre for Advances in Epidemiology and IT
36
Chemical Pathology
37
Chief Allied Health Office
38
Chronic Disease Management
40
Clinical Trials Unit
42
Community Care Allied Health Services
47
Community Care Program
49
Emergency Department
50
Endocrinology and Diabetes
51
Geriatric Medicine, Rehabilitation Aged and Community Care
54
Haematology
55
Immunology
62
Infectious Diseases, Microbiology and Infection Prevention and Control
64
Inflammatory Bowel Disease Research
65
Intensive Care Research
67
Liver Research
70
Medical Assessment and Planning
72
Medical Oncology
73
Microbiology
78
Neonatology
80
Neurology
84
Population Health
85
Radiation Oncology
88
Renal Medicine
91
Translational Research Unit
92
Trauma and Orthopaedic Research Unit
95
Publications
101
ACT Health Research Review 2013 & 2014
4
Glossary
ANU
Australian National University
UC University of Canberra
UNSW
University of NSW
JCSMR
John Curtin School of Medical Research
HREG
Human Research Ethics and Governance
HREC
Human Research Ethics Committee
5
Minister for Health
I have pleasure in presenting the 2013–2014 biennial
ACT Health Research Review. The review provides
a summary of the progress and achievements made
by ACT Health’s health and medical research staff
and students over the past two years.
This review highlights research findings that will
enhance education and healthcare with direct
benefits to patients and the public, now and into
the future.
Multidisciplinary collaborations demonstrate
the ACT Health’s commitment to translating its
expertise in fundamental biomedical research from
bench to bedside.
Once again, the past two years has seen a culture
of research being firmly embedded in ACT Health
and further enhanced by the continued success
of the Canberra Health Annual Research Meeting
(CHARM). In the past two years, we have seen
a consistent rise in submissions to CHARM and
have introduced social media and livestream of
key presentations, providing greater access to
the meeting to researchers and interested public
worldwide. In 2014, the ACT Health Research
Office received an Australia Day Achievement
Medallion for their management and continued
success of the meeting.
I would like to acknowledge the success of
Professor Matthew Cook who, with colleagues,
received $2.5 million in funding over five years from
the National Health and Medical Research Council
(NHMRC) for the Centre of Research Excellence
in Personalised Immunology (CPI) (http://jcsmr.anu.
edu.au/research/cpi). The CPI opened in April 2014
and operates simultaneously at the cutting edge of
biomedical research, while implementing genomics
into medical practice.
Another key centre opening during the period
of this report was the ACT Regional Health
Observatory (RHO), in which ACT Health is
an active partner. The centre was established to
respond to local and regional needs in addressing
the burden of chronic disease.
The RHO will enable integrated information,
intelligence and research to support evidence-based
policy, research, practice, and education. Through the
partnerships established by the RHO, the aim is to
increase co-research capacity, undertake high quality
research to support public health policy development
and evidence translation, and to develop indicators
and intelligence on the environmental and social
determinants of population health.
The RHO is hosted by the Centre for Research
and Action in Public Health (CeRAPH) at the
University of Canberra. In addition to the University
of Canberra and ACT Health, RHO partners include
the ACT Medicare Local, Heart Foundation and
Ochre Health.
Both centres demonstrate how ACT Health’s
collaborations enhance the region’s research
capability for the benefit of consumers.
Simon Corbell
6
ACT Health
Success in health research is essential for timely
translation of outcomes to health care practice.
The high quality of ACT Health’s researchers is
recognised worldwide and this report gives the
reader an overview of the many projects being
conducted. Of note, are the successes of the
Trauma and Orthopaedic group, led by Professor
Paul Smith. This group continues to grow its
research profile through collaborations, student
projects and successful funding bids. A glance at
their project and publication lists demonstrates
the extensive range of their research, which
through their collaborations includes the fields
of engineering, anatomy, materials science,
physiotherapy and image processing.
Also of note is the Translational Research Group,
under the direction of Professor Matthew Cook. This
group continues to build on their successful research
record in immunological disease. Their research is
supported by NHMRC program and project grants
and recently they have been successful in gaining an
NHMRC Centre for Research Excellence grant.
Those who contributed to the contents of
this report and to its production are to be
congratulated. I believe the report demonstrates
that health research in the ACT is core business
and that research and innovation are a priority
within ACT Health.
Ms Nicole Feely
Director General
ACT Health
7
Director of Research
This is my first report as Director of Research, an
appointment I am delighted to have had since July
2014. The current Review shows the wide variety of
research conducted by ACT Health staff – there is
much to celebrate.
Let me acknowledge the work of Dr Hannah Clarke
and all Research Office staff. They have made me
very welcome, and continue to help researchers to
complete their projects in countless ways.
The Human Research Ethics Committee also
continues to improve its approach, maintaining
the high standard of ethical review and assisting
researchers. My thanks to Dr Louise Morauta
PSM, Chair, and all Committee members for their
magnificent effort.
A major initiative is the development of the
ACT Health Research Plan, which will be the
subject of wide consultation over the year 2015–16.
I expect that the final plan will endorse greater
integration of research into the mainstream of
activity of all Divisions of ACT Health, promoting
a culture of innovation. Please engage in this
consultation – doing so will help to strengthen
the governance that is essential for expanding our
research enterprise.
Professor Charles Guest
8
ACT Health is involved in numerous health
research projects in the ACT region, nationally and
internationally. The cornerstone of ACT Health’s
emphasis on university research is the ANU Medical
School. With over 5,000 employees, ACT Health
is involved in a large number of multidisciplinary
research projects across the health portfolio.
ACT Health’s active research portfolio includes
basic science research, translational and clinical
research. ACT Health’s researchers have affiliations
with regional and national universities, including the
Australian National University, the University of
Canberra, Australian Catholic University and the
University of New South Wales Canberra.
The ACT Health Research Office provides a focal
point for research support and works closely
with its regional partners, as well as other national
and international institutions to ensure research
governance is managed appropriately and services
are provided in a timely manner.
The office provides ongoing support and
guidance to researchers based in ACT Health.
This includes medical staff, adjuncts and Higher
Degree by Research students as well as allied health
professionals, nursing and health professionals
involved in research.
The aims of the office are to:
l
coordinate the administration of research
activities, in particular research and ethics
committees and research scholarships, awards
and fellowships
l
provide advocacy advice, assistance and
encouragement to all staff wishing to pursue
clinical research activities
l
encourage and support health care workers to
participate in research activity
l
optimise translation of research into clinical
practice and health policy
l
encourage and foster multi-disciplinary interorganisational collaborative relationships to
optimise opportunities for research
l
provide leadership in ACT Health for the
conduct of medical research that can be
marketed externally to secure greater levels of
funding for research
l
provide services to ensure the quality and
competitiveness of new submissions for national
and international research funding applications
l
manage research laboratory and animal facilities
l
coordinate the Canberra Health Annual
Research Meeting.
A key highlight during the reporting period was
the awarding of an ACT Health Australia Day
Achievement Medallion for the Canberra Health
Annual Research Meeting 2014 to the ACT Health
Research Office.
9
Staff
Professor David Brewster, Director of Research
(Jan 2013)
Professor Matthew Cook, Director of Research
(April 2013 to June 2014)
Professor Charles Guest, Director of Research
(June 2014 to present)
Dr Hannah Clarke, Director Research Operations
Dr Bruce Shadbolt, Director Centre for Advances in
Epidemiology and IT
Professor Matthew Cook, Director Translational
Research
Mrs August Marchesi, Manager Human Research
Ethics and Governance (HREG)
Mrs Katherine Johnson, Manager Clinical Trials
Ms Ayumi Hosaka, Senior Animal Technician
Mr Bee Souvannaphong, Specialist Facility and
Safety Officer
Mr James Horne, Safety Officer (to July 2014)
Mr Matthew Wafer, Project Officer
Ms Sarah Flood, Administrative Officer – HREG
Mrs Gillian Fox, Administrative Officer – HREG
Mrs Minu Matthew, Administrative Officer
Ms Delia James, Animal Technician
Ms Zsuzsa Pazstor, Animal Technician
Ms Maria Damiano, Animal Technician
Ms Michelle Stephens, Animal Technician
(to September 2013)
Awards
ACT Health Australia Day Achievement Medallion
for the Canberra Health Annual Research
Meeting 2014
Australia New Zealand Laboratory Animal
Association Travel Scholarship 2014
Ms Delia James
First prize, British Medical Association Book
Awards, 2014 (for Oxford Handbook of Public
Health Practice, 3rd Edition, 2013)
Professor Charles Guest
Dr Hannah Clarke
Director Research Operations
10
The ACT Health Human Research Ethics
Committee is the institutional ethics committee
for ACT Health. The Committee is appointed by
ACT Health and constituted according to the
National Statement on Ethical Conduct in Human
Research 2007. It is one of 12 HRECs in the ACT
and the only one that is certified by the National
Health and Medical Research Council (NHMRC) for
single review of multi-centre clinical trials.
Under the ACT Health Research Practice Policy,
the Committee is responsible for overseeing the
review and approval of human research conducted
in ACT Health and for monitoring human research
conducted in ACT Health. The Committee also
provides the same service to researchers in the
ACT who submit proposals to the Committee
and who come from institutions where there is no
HREC available.
Membership of HREC in
2013 and 2014
Professor John Biggs, Chair (until April 2014)
Dr Louise Morauta, Lay member (2010–2014);
Chair (from April 2014)
Associate Professor Peter Hickman, Deputy Chair
(until July 2014)
Associate Professor Frank van Haren, Researcher
(2012–2014); Deputy Chair (from July 2014)
Professor Walter Abhayaratna, Researcher
Ms Kimberley Baillie, Lawyer
Ms Margaret Blood, Lay person (from July 2014)
Professor Doug Boer, Health Care Provider (from
May 2013)
Professor Paul Craft, Researcher (from December
2014)
Associate Professor Marian Currie, Researcher
Professor Geoff Farrell, Researcher (from
March 2013)
Rev Doug Hutchinson, Pastoral Care Provider
Dr Tony Huynh, Researcher (May 2013 to
January 2014)
Ms Julie Kussy, Health Care Provider
Dr Ray Lovett, Researcher
Dr Jason Mazanov, Researcher (until June 2014)
Mr John Morrissey, Lawyer
Dr Anna Olsen, Researcher (from August 2014)
Professor Paul Pavli, Researcher (until October 2013)
Dr Manoj Singh, Researcher (until January 2014)
Associate Professor Dipti Talaulikar, Researcher
Ms Lyn Todd, Pharmacist (from February 2013)
Mr Luke Williamson, Lay person
Performance in 2013 and 2014
The Committee reviewed 205 projects and
approved 182 during 2013 and 2014. Of the
remaining projects, eight were not approved
against the National Statement criteria; five had
not responded to feedback by the end of 2014;
one was deemed to be a quality improvement
activity not requiring HREC approval; and six were
withdrawn by the applicants. The average time
for the Committee to approve a proposal was
65 days from the date of submission, of which 36
days were time with the Committee and 29 days
were time when the proposal was back with the
researcher for further work.
The Low Risk Sub-Committee (LRSC), which
reviews projects in which the only foreseeable
risk for participants is one of discomfort (National
Statement, p 16), reviewed a much higher number
of proposals. LRSC reviewed 395 projects during
the two years and approved 337. Of the remaining
projects, 25 had not responded to feedback by
the due date or been withdrawn by the applicant;
four were referred to the main Committee; and
one had not responded to feedback by the end of
2014. Following the release of the NHMRC paper
on Ethical Approval for Quality Assurance Projects,
28 applicants were informed that their quality
assurance proposal did not require ethical review/
approval. It is likely that the spike in quality assurance
projects not approved in 2014 (24 of the 28) is a
one off as researchers become familiar with the
new policy. The average time from closing date for
submissions to notification of approval by LRSC was
15 days, including time when the proposal was back
with the researcher for further work.
11
Our approval rates are comparable with those of
other HRECs (as reported by NHMRC). It would
appear that our time performance for HREC
and LRSC decisions is also comparable although
published data are scarce on the time question.
The Clinical Trials Sub-Committee (CTSC), the
Social Research Sub-Committee (SRSC) and the
Survey Resource Group (SRG) review projects and
provide advice to HREC. During 2013 and 2014, the
CTSC reviewed 83 clinical trial projects, the SRSC
reviewed 82 social science projects and the SRG
reviewed the survey components of 176 projects
(this latter number included projects going to LRSC
and those not requiring ethical approval).
Developments in 2013 and 2014
There have been four main developments in
Committee processes in the two years, all designed
to improve the quality of decision making and
service the Committee provides.
First, in 2013 the Social Research Sub-Committee
was established to provide expert advice to the
Committee on the increasing number of social
research projects coming to the Committee. By
2013 around 40 per cent of proposals coming
to the Committee fell into this category. The
Committee required assistance to assess the
Research Merit and Integrity of these projects when
it only had two members who were current social
researchers. Over the two years, as already noted,
this expert committee reviewed as many proposals
as the Clinical Trials Sub-Committee and has added
considerably to the quality of the Committee’s
decision making.
Second, in 2014 there was a change in the
composition of the Low Risk Sub-Committee
(LRSC). The LRSC was reestablished with a focus
on expert membership to provide a sounder basis
for assessment of the 200 or so proposals that
go through the LRSC every year. The LRSC now
consists of the Chair of the HREC, one member
with medical expertise and one member with social
science expertise. We are looking for continuity of
membership over six to 12-month periods so that
greater consistency and expertise is developed in
the consideration of LRSC proposals.
Third, the Committee, working with the Director
of the Research, has opened discussions with some
of the other HRECs in the ACT with the aim of
streamlining processes for the significant number
of researchers and research students who have to
take their research projects through the ACT Health
HREC and another HREC in the ACT. At the
moment this involves double paperwork and on
occasion conflicting decisions by the two HRECs
involved. We are hopeful that some of this work
will bear fruit in future and note that an agreement
on streamlining was reached with the University of
Canberra HREC in early 2015.
Fourth, in 2014 we received approval from
ACT Health to appoint a third staff member to the
Secretariat. This position will be fully funded from
the Committee’s own income from fees. It will
significantly add to the capacity of the Secretariat
to improve services to the Committee and our
research community.
What makes the Committee work?
The Committee and its sub-committees rely
enormously on the dedication, enthusiasm
and good will of members and the staff of the
Secretariat led by Ms August Marchesi. I would
like to thank all the people who have contributed
to the work of the Committee over the past two
years. I would also like to acknowledge the support
of ACT Health for the Committee, particularly
through the Director of Research.
I would particularly like to mention and thank three
people who have contributed more than most to
the successes the Committee has had:
l
my predecessor, Professor John Biggs, who
ably chaired the Committee for four years
during a period in which the Committee was
transformed into a modern high-functioning
HREC and the Committee achieved
Certification from the NHMRC
l
Associate Professor Peter Hickman, a longserving member of the Committee who was
Deputy Chair during an important period of
development for the Committee and also
guided me wisely in my early period as a new
Chair
l
Ms August Marchesi, an exceptional Secretary
to the Committee, who has played such an
important role in bringing the Committee to its
current position and supporting us in our work.
Dr Louise Morauta PSM
Chair
12
Research Meetings 2013–2014
Canberra Health Annual
Research Meeting –
CHARM 2013
CHARM was hosted by the ACT Health Research
Office at the Canberra Hospital in August 2013.
The meeting was held from 20–23 August, in
conjunction with National Science Week. 171
abstracts were received for the meeting. More than
200 health and medical researchers from the region
attended the meeting. All meeting processes were
administered through the Research Office.
Keynote speakers
Professor Richard Osborne, Chair in Public
Health, School of Health and Social Development,
Deakin University, VIC – Health literacy: patient
and organisational-level opportunities to improve
quality, safety and health outcomes.
l
Professor Caroline MacMillen, Vice Chancellor
University of Newcastle, NSW – The early origins
of a life of obesity.
l
Professor Mark von Itzstein, Director Institute of
Glycomics, Griffith University, NSW – Institute
for Glycomics – Insight into drug discovery and
vaccine development – from bench to bedside.
l
Winthrop Professor Fiona Wood AM,
University of Western Australia, Australian of
the Year 2005 – Striving for excellence or the
quest for scarless healing.
l
There was an evening poster viewing session and
a close of meeting and awards dinner held at The
Lobby Restaurant in Parkes.
Prizes awarded
The Canberra Hospital Private Practice Fund Award
for the Best Student Poster – Mr Fahrettin Haczeyni
(Liver Research Unit) – Activation of Tlr9 and Myd88
is required for adipose and liver inflammation in dietinduced obesity related NASH.
for the Best Student Oral – Ms Ellen Mckenzie
(Dept Psychology University of Canberra) – Nursing
students’ intentions to work in dementia care: influence
of age, ageism and perceived barriers.
Radiation Oncology Private Practice Trust Fund
Award for the Best Laboratory Research Poster –
Mr Jonathon Smiles (ACT Pathology) – Prevention of
cisplatin-induced nephrotoxicity by dichloroacetate.
Award for the Best Laboratory Research Oral
Presentation – Ms Rebecca Haddock (Eccles
Institute of Neuroscience) – ngf-producing immune
cells drive sympathetic neurogenic hypertension.
Professor Guan Chong Award for the Best Clinical
Research Oral Presentation – Associate Professor
Drew Richardson (Emergency Dept Canberra
Hospital) – Reduced ED crowding with changes to
bed management.
13
DiscoverQuick Award for the Best Clinical Research
Poster Presentation – Ms Leanne Ehrlich (Dept of
Neonatology) – From novice to expert - graduate
nurse education in NICU.
ACT Health Research Office and Human Research
Ethics Committee Departmental Award for most
abstract submissions – Trauma and Orthopaedic
Research Unit. Runners up were the Department
of Neonatology.
Canberra Health Annual
Research Meeting –
CHARM 2014
CHARM was held from 12–14 August in 2014.
This meeting saw yet another increase in abstract
submissions to 198, with the number of registrations
increasing two-fold to 520.
The meeting featured four keynote speakers, one
guest speaker, and four AbstrACT sessions, where
invited speakers shared their experiences of medical
research in the ACT, and 66 presentations. There
were also two workshops held on Ethics and
Research skills training. Finally, there was a very well
attended poster viewing session and awards dinner.
In 2014, social media and livestream of the keynote
speaker events meant that the public, as well as
regional health and medical researchers, were able to
access the event. The livestream website reportedly
received over 4,000 hits during the week of CHARM.
Significant sponsorship was received from our
University partners the Australian National
University, The University of Canberra, University
of New South Wales Canberra and the Australian
Catholic University. As in previous years, this
meeting also received a generous donation from
the Canberra Hospital Foundation. The organising
committee would like to express their sincere
thanks to all the sponsors of this meeting.
Keynote speakers
Professor M Lindsay Grayson, Infectious
Diseases Department, Austin Health,
Department of Medicine, University of
Melbourne, Melbourne, Vic – Superbugs in the
Supermarket? Why the future of antibiotics is linked
to food and what Australia can do about it.
l
Dr Norman Swan, Multi-award winning
broadcaster, journalist and health commentator
– Why is practical discovery so slow? Getting
beneath the bull in translation.
l
Professor Peter FM Choong, Sir Hugh Devine,
Chair of Surgery, Head of University of
Melbourne Department of Surgery, St Vincent’s
Hospital, VIC – The challenge of academic surgery
in the new millennium.
l
Dr Charlie Teo, Neurosurgeon, Director
of Sydney’s Centre for Minimally Invasive
Neurosurgery, Founder of the Cure for Life
Foundation – The changing face of neurosurgery.
l
Once again there was an evening poster session and
the close of meeting and awards dinner held at The
Great Hall, University House, Acton.
Prizes awarded
for the Best Student Poster – Ms Lori Delaney
(RCNMP) – Patients’ quality of sleep at Canberra
Hospital.
for the Best Student Oral – Ms Fui Jiun Choong
(JCSMR) – Molecular insights into the loss of heparan
sulfate (HS) during islet isolation and HS recovery after
islet transplantation.
Award for the Best Laboratory Research Poster
– Mr David Croaker (Dept Paediatric Surgery) –
Diffuse effects of an endothelin b receptor (ednrb)
mutation: more on the non-enteric phenotype of
Hirschsprung disease.
Award for the Best Laboratory Research Oral
Presentation – Ms Tenzin Dagpo (Endocrinology and
Diabetes Research) – Role of adipose tissue in the
pathogenesis of non-alcoholic steatohepatitis (NASH)
in high fat fed foz/foz mice.
14
Professor Guan Chong Award for the Best Clinical
Research Oral Presentation – Dr Elizabeth Sturgiss
(AUGP) – Treating overweight and obese adults in
General Practice – a systematic review.
DiscoverQuick Award for the Best Clinical
Research Poster Presentation – Ms Rachael
Jeffery (Dept of Neonatology) – CeasIng Cpap At
standarD criteriA (CICADA): Implementing CICADA
reduces CPAP duration.
The ACT Health Chief Allied Health Office Best
Allied Health Oral Presentation – Mrs Bernie
Bissett (Dept Physiotherapy) – Weaned but weak
and weary: Inspiratory muscle weakness and raised
perceived exertion in adults following 7 days of
mechanical ventilation.
The ACT Health Chief Allied Health Office Best
Allied Health Poster Presentation – Ms Tasfia
Khan (Cytogenetics) – FISH (Fluorescent In situ
Hybridisation) on trephine imprints to achieve
cytogenetic results on ‘dry tap’ bone marrow collections.
ACT Health Research Office Viewers’ Choice Award
– Ms Evi Arfianti (Liver Research Group) – Exercise
slows growth of dysplastic hepatocytes by improving
insulin sensitivity and enhancing DNA damage
surveillance pathways in mice genetically predisposed
to obesity and diabetes.
15
The University of New South Wales Canberra
Best Overall Poster Presentation – Ms Lori
Delaney (RCNMP) – Patients’ quality of sleep at
Canberra Hospital.
Departmental Award for most abstract submissions
– Research Centre for Nursing and Midwifery
Practice. Runners up were Allied Health.
Special thanks go to the organising committee,
scientific review committee and staff, whose hard work
helped made these meetings a great event for all.
The ACT Health Research Office received an
ACT Health Australia Day Achievement Medallion for
the 2014 Canberra Health Annual Research Meeting.
Dr Hannah Clarke
Director Research Operations
Research
18
Academic Unit of General Practice
The Academic Unit of General Practice (AUGP) is
co-funded by ACT Health and the ANU Medical
School. Since its establishment in 1997, the AUGP
has made extensive contributions to the delivery of
the ANU Medical School program, as well as to the
junior medical officers, GP vocational trainees and
practicing doctors’ medical education programs.
The AUGP has developed research activities
that encompass child health, integrated service
development, clinical research, individual routes to
health and healing, social determinants of medical
care, and scholarship in teaching and learning.
The AUGP has led the research building from the
ACT Health Kindergarten Health Check.
In addition, the AUGP has contributed to policy
development in the ACT and wider Australian
health service through the work of the GP Advisor,
the work of Integrated Clinical Training Network
and Health Workforce Australia, committee
work, liaison with the ACT Medicare Local and
communication of its research findings.
The AUGP and academics provide clinical services
to Winnunga Nimmityjah Aboriginal Health
Service, to Companion House Refugee Health
Service and to mainstream general practice in the
ACT. Senior members of the AUGP have pivotal
roles with the Royal Australian College of General
Practitioners (RACGP), ACT Medicare Local, the
Australian Association of Academic Primary Care
and the Confederation of Postgraduate Medical
Education Councils.
Staff
Professor Kirsty Douglas, Director, Academic Unit of
General Practice
Associate Professor Katrina Anderson, Academic
Unit of General Practice
Associate Professor Christine Phillips, Social
Foundations Medicine, Australian National
University
Associate Professor Jennifer Thomson, Researcher,
ANU Medical School
Dr Marianne Bookallil, GP Advisor
Dr Charles Sleiman, Lecturer
Dr Elizabeth Sturgiss, Lecturer, ANU Medical School
Dr Janine Rowse, Lecturer, ANU Medical School
Dr Rebecca Kathage, Lecturer, ANU Medical School
Dr Susan Wearne, Adjunct Senior Lecturer and
Medical Advisor, Health Workforce Division,
Department of Health
Dr Louise Stone, Adjunct Senior Lecturer and
Medical Adviser, Health Workforce Division,
Ms Karen Ciszek, AUGP Research Nurse,
Kindergarten Health Check
Ms Emily Haesler, Visiting Research Fellow, PhD
candidate
Mr Nicholas Elmitt, Researcher, Australian National
University
Students
Dr Penny Burns, PhD, ANU Medical School
Supervisors: Professor Beverly Raphael, Professor
Kirsty Douglas, Dr Wendy Hu (UWS), Dr Peter
Aitken (Qld)
Ms Lesley Piko, PhD, ANU Medical School
Supervisors: Associate Professor Christine
Phillips, Professor Kirsty Douglas, Professor Marjan
Kljakovic (dec.)
19
Ms Danielle Dries, MChB, ANU Medical School
Supervisors: Dr Ana Herceg, Dr Marianne Bookallil
Mr Thomas Shaw, MChB, ANU Medical School
Supervisors: Dr Marianne Bookallil, Dr Ana Herceg
Ms Sarah Davis, MChB, ANU Medical School
Supervisors: Professor Kirsty Douglas
Ms Elise Warren, MChB, ANU Medical School
Supervisor: Dr Marianne Bookallil
Mr Frederick Chung, MChB, ANU Medical School
Supervisor: Dr Ana Herceg
Collaborators
Mr Vlad Aleksandric, ACT Medicare Local
Graduations
Dr Lesley Piko, PhD, Australian National University
Visitors
Mr Todd Patenaude, The Marist Brothers, New York
Research projects
Project title: Integration in Primary Health Care:
Organisational Process or Patient Outcome
or Both? Lessons from the First Generation of
Integrated Primary Health Care Centres
Principal investigators: K Douglas
Funding source: Australian Primary Health Care
Research Institute (APHCRI)
Grant amount: $150,000
Project title: An Implementation Pilot Study of
The Change Program – A Gp-Delivered Weight
Loss Program for Adults in Primary Care
Principal investigators: E Sturgiss
Funding source: Australian Primary Health Care
Research Institute (APHCRI)
Project title: Treating Adult Obesity in General
Practice – Developing a Weight Management
Strategy for General Practitioners
Principal investigators: E Sturgiss
Funding source: RACGP research grants supported
by the Independent Practitioner Network Pty Ltd
Project title: Evaluation of Collaborative
Development of Preventive Disease Health
Resources for the Karen Community in Canberra
Principal investigators: C Phillips
Funding source: Australian National Health
Prevention Agency
Grant amount: $17,000 (component of grant made
to ACT Medicare Local)
Project title: What Strategies are Acceptable to
Primary Caregivers when Informing them of their
Child’s Body Mass Index (BMI) Result as Gathered
through the Kindergarten Health Check (KHC)? What
Type of Information do Primary Caregivers Find Helpful
in Regard to Potential Management Options to Follow
Up a High BMI Result of their Child?
Principal investigators: R Kathage
Funding source: Academic Unit of General Practice;
Australian National University; Coast City Country
Training
Project title: Comparison of Health Service
Attendance by Asylum Seekers and Refugees with
Permanent Visas in the ACT, 2011–2013
Principal investigators: J Rowse
Funding source: Academic Unit of General Practice;
Coast City Country Training
Project title: Enhancing Vertically Integrated
General Practice Education through Understanding
the Learner’s Perspective
Principal investigators: K Anderson
Funding source: GP Education Training/City Coast
Country GP Training
Project title: How Can We Best Educate
GP Registrars on Practice Management and
Ownership?
Principal investigators: E Sturgiss, K Anderson,
M Liedvogel, E Haesler
Funding source: Academic Registrar Post, General
Practice Education Training and City Coast Country
GP Training
Project title: Increasing Uptake of PAP Smears at
an Urban Aboriginal Community Controlled Health
Service: Translational Research
Principal investigators: M Dorrington, A Herceg,
K Douglas, M Bookallil, J Tongs
Funding source: Academic Registrar Post, GP
Education Training and City Coast Country GP
Training
Project title: Registrar Educational Needs for
Practice Management and Ownership
Principal investigator: K Anderson
Funding source: City Coast Country GP Training
Awards
CHARM 2014 – Professor Guan Chong Award for
the best Clinical Research Oral Presentation
Dr Elizabeth Sturgiss
20
Academic Unit of Internal Medicine
The Academic Unit of Internal Medicine (AUIM)
was established in 2002 as part of the ANU
Medical School, Canberra Hospital, with the mission
to enhance evidence-based medical education
and to conduct innovative, high quality clinical,
epidemiological and laboratory-based medical
research. The unit’s research program incorporates
epidemiological, clinical and laboratory research
nodes. Areas of focus for 2013–2014 were
chlamydia, other sexually transmitted infections,
perinatal mental health, medical education, HIV, head
lice management and cardiology research.
Staff
Professor Walter Abhayaratna, Professor of
Cardiovascular Medicine, Australian National
University
Professor Francis Bowden, Professor of Medicine,
Mrs Louise Deeks, Research Officer
Dr Jane Thompson, Senior Research Officer
Dr Sarah Martin, Lecturer ANU Medical School;
Director, Canberra Sexual Health Centre
Dr Alexandra Tyson, Lecturer ANU Medical School;
Staff Specialist Canberra Sexual Health Centre
Mr Rendry Del Rosario, CNC Canberra Sexual
Health Centre (CSHC)
Ms Anne Baynes, Project Officer (Chlamydia
Contact Tracing)
Ms Kristen Reed, Project Officer (Chlamydia
Contact Tracing)
Ms Maureen Todkill, Project Officer (Stamp out
Chlamydia)
Ms Shannon Woodward, Nurse Practitioner CSHC
Ms Debbie Morgan, Outreach Nurse CSHC
Ms Denise Fairall, Outreach Nurse CSHC
Ms Miranda Sherley, Registrar CSHC
Students
Mr Mitchell Parker, MBBS, Australian National
University
Supervisor: Professor Frank Bowden
Ms Kerrie Aust, MBBS, Australian National University
Supervisor: Associate Professor Marian Currie
Ms Erika Raymundo, BSc, Australian National
University
Ms Sally Cox, BSc, University of Canberra
Ms Julie Styles, MBBS, Australian National University
Supervisor: Associate Professor Marian Currie
Ms Joan Flores, MBBS, Australian National University
Supervisor: Professor Walter Abhayaratna
Ms Sarah Taylor, MBBS, Australian National University
Supervisor: Professor Julia Potter
Mr Alan Pierce, MBBS, Australian National University
Ms Annie Su, MBBS, Australian National University
Ms Rebecca Moses, MBBS, Australian National
University
21
Mr Steven Thammavongsa, MBBS, Australian
National University
Ms Svetha Rao, MBBS, Australian National University
Ms Arunima Jain, MBBS, Australian National
University
Ms Marie Rose Mansfield, MBBS, Australian National
University
Mr Indika Gawaramanna, PhD, Australian National
University
Ms Hani Abed, PhD, Australian National University
Ms Muayad Alasady, PhD, Australian National
University
Dr Rajeev Pathak, PhD, Australian National
University
Ms Lisa Olive, PhD, Australian National University
Dr Pushpani Herath, PhD, Australian National
University
Dr Ben Jacobson, MPhil, Australian National
University
Research projects
Project title: ASPREE – Aspirin in Reducing Events
in the Elderly
Principal investigator: W Abhayaratna
Funding source: National Institute of Health
(NIH), National Institute of Aging (NIA), USA
National Health and Medical Research Council
(NHMRC)
Project title: ASPREE ENVIS-ion – Aspirin for
the Prevention of Cognitive Decline in the Elderly
(A Neuro-Vascular Imaging Study from ASPREE
(A Substudy of the ASPREE Study)
Funding source: NHMRC
Project title: ASPREE Healthy Ageing Biobank –
Funding source: CSIRO
Project title: LOOK Study during Adolescence –
Lifestyle of our Kids
Funding source: Australian Sports Commission,
Canberra Hospital Private Practice Fund
Project title: Low CBP Study – Targeted
LOWering of Central Blood Pressure in Patients
with Hypertension: a Randomised Controlled Trial
Project title: CAAN-AF – CRT and AV Nodal
Ablation Trial in AF Patients
Project title: SAFETY – Standard vs Atrial
Fibrillation-spEcific ManagemenT StudY: The
SAFETY Study – A Multi-Centre Randomised
Controlled Trial
22
Academic Unit of Ophthalmology
The Academic Unit of Ophthalmology continues its
ongoing research activities, particularly in the fields
of retinal imaging, diabetic retinopathy, age‑related
macular degeneration and clinical outcomes
monitoring in surgical retinal disease. We have built
a strong collaboration with JCSMR. We support
JCSMR in its ongoing research activity investigating
objective measures of retinal function, novel uses of
near infra-red light in protection from retinal disease.
JCSMR, in turn, supports the research activity of the
ophthalmic clinicians with co-supervision of one
PhD student working on macular hole research.
Staff
Associate Professor Rohan Essex, Senior Staff
Specialist
Dr Randev Mendis, Staff Specialist
Ms Amanda Wylie, Research Nurse
Students
Ms Zabrina Abdool, MBBS, PhD, Australian National
University
Supervisor: Associate Professor Rohan Essex
Dr Mariana Scheele, MBBS, Masters of
Ophthalmology, University of Sydney
Dr Ali Haider, MBBS, Masters of Ophthalmology,
University of Sydney
Collaborators
Professor Mark Gillies, Save Sight Institute, Sydney
Eye Hospital
Dr Kathryn Burdon, Flinders University
Professor Ted Maddess, Australian National
University
Research projects
Project title: Determinants of Outcome in Macular
Hole Surgery
Principal investigator: R Essex
Funding source: Ophthalmic Research Institute of
Australia
Awards
ACT Health Excellence in Healthcare Award 2014
(Systems Support)
Associate Professor Rohan Essex and
Dr Bruce Shadbolt
Grants
Recipients: T Maddess, A James, R Essex, J Provis,
F Sabeti, R Mendis, C Carle
Project title: Novel Functional Testing for Macular
Degeneration
23
Acute Support Physiotherapy
The Acute Support (AS) Physiotherapy Department
of the Canberra Hospital provides acute clinical
physiotherapy services to inpatients and outpatients.
With the equivalent of approximately 40 fulltime
staff, the Physiotherapy Department does not
have funding for research staff per se, yet has been
involved in formal clinically focused research projects
and significant publications in collaboration with
other areas across ACT Health in 2013–2014.
AS Physiotherapy is currently supporting two PhD
students and one Masters student to undertake
their research projects in-house. AS Physiotherapy
have research affiliations with the Australian National
University, University of Canberra, University of
Queensland and University of South Australia.
In 2014, the AS Physiotherapy team won the Chief
Allied Health Officer’s Award for Excellence in
Research. This award recognised the numerous
physiotherapists in our team who have celebrated
research achievements in recent years, none of
which would have been possible without the
support of a dynamic and flexible clinical team,
which supports research activities embedded in
clinical practice.
In 2013, AS Physiotherapy staff (Ms Margot Green
and Mrs Bernie Bissett) were invited speakers at
the Australia New Zealand Intensive Care Society
conference in Hobart, and in 2014 Mrs Bernie Bissett
was also invited to present at the International
Physical Medicine and Rehabilitation in Intensive Care
conference in San Diego. The team celebrated further
success at CHARM 2014, with three presentations
and several posters, including the prize for Best Allied
Health Presentation. Further wins were achieved
at the ACT Australian Physiotherapy Association
Research Symposium, where members of our team
were awarded Best Paper (Mrs Bernie Bissett) and
Best Poster (Ms Tayne Ryall, Ms Megan Girdlestone
and Ms Kathy Terrell).
The department’s main research areas continue to be
in early rehabilitation in ICU, physiotherapy following
hip replacement, and extended scope physiotherapy.
However, in 2014 we expanded this portfolio
to include ventilator hyperinflation in ICU, lung
ultrasound by physiotherapists, rehabilitation for renal
patients, inspiratory muscle training for pulmonary
rehabilitation patients, and follow-up of ICU survivors.
We work closely with other research teams across
ACT Health, and now have representation on the
ICU Research Executive committee.
AS Physiotherapy is grateful for the financial support
of the Chief Allied Health Office in the past 12
months and looks forward to continuing our
patient-centred clinical research in years to come.
Staff
Mrs Kerry Boyd, Acting Manager, Acute Support
Physiotherapy
Mrs Bernie Bissett, Senior Physiotherapist, Canberra
Hospital; Clinical Assistant Professor, Discipline of
Physiotherapy, University of Canberra
Mrs Corinne Coulter, Senior Orthopaedic
Physiotherapist
Ms Joanne Morris, Extended Scope Physiotherapist
Ms Margot Green, Cardiorespiratory Clinical
Educator Physiotherapist
Mr Vince Marzano, HP3 ICU Physiotherapist
Mrs Maja Leech, HP2 Physiotherapist
Mrs Joelie Parker, HP3 Cardiorespiratory
Physiotherapist
Mrs Lisa Gilmore, Manager Acute Support
Physiotherapy (2008–2014)
24
Students
Mrs Bernie Bissett, PhD, University of Queensland
Supervisors: Dr Jenny Paratz, University of
Queensland; Dr Rob Boots, University of
Queensland; Dr Anne Ledtischke
Mrs Corinne Coulter, Master of Philosophy
(Research), Australian National University
Supervisors: Associate Professor Jennie Scarvell,
University of Canberra; Professor Paul Smith
Ms Joanne Morris, PhD, University of Canberra
Supervisors: Professor Karen Grimmer, Professor
Gordon Waddington, Professor Rachel Davey,
Mr Robert Marshall
Awards
Chief Allied Health Officer’s Awards for
Excellence 2014 (Research)
Acute Support Physiotherapy Team
CHARM 2014 – Best Allied Health Oral
Presentation
Mrs Bernie Bissett
Best Paper, ACT Australian Physiotherapy
Association Research Symposium 2014
Mrs Bernie Bissett
Best Poster, ACT Australian Physiotherapy
Ms Tayne Ryall, Ms Megan Girdlestone and
Ms Kathy Terrell
Grants
Recipient: M Green
Funding source: Chief Allied Health Officer
Research Support Grants
Project title: GoSAM (Early Mobilisation in ICU)
Recipients: B Bissett, R Stanton
Project title: Evaluating Student Experience and
Developing Physiotherapy Supervisors
Grant amount: $504
Recipient: V Marzano
Project title: Ventilator Hyperinflation Project
Recipient: J Parker
Project title: Renal Rehabilitation Project
Recipient: J Parker
Project title: Inspiratory Muscle Training in
Pulmonary Rehabilitation Project
Recipients: T Ryall, M Girdlestone, K Terrell
Project title: Increasing Meaningful Therapy Time
(poster)
Grant amount: $250
Recipient: J Morris
Project title: Arthroplasty Follow Up Project
Recipients: B Bissett, M Green
Project title: ICU follow up clinic project
25
Academic Unit of Psychiatry and
Addiction Medicine
The Academic Unit of Psychiatry and Addiction
Medicine has an active and broad research program,
covering all aspects of psychiatry across the lifespan.
Key areas of research include: population mental
health; disasters; climate change; trauma, loss and
grief; neuropsychiatry; cognitive neuroscience; ageing,
physical health, health risk perceptions; perinatal
mental health; and childhood adversity. The team is
integrated with Mental Health ACT and provides
high level research and policy advice to ACT Health
and a range of external organisations.
Our key achievements include the establishment of
the Australian United States Scandinavian Imaging
Exchange (AUSSIE) involving: ANU, UCLA, UNC,
USC, Karolinska Institute, Lund University, University
of Melbourne, UNSW, and UWA for cutting edge
interdisciplinary neuroimaging research on the
subcortical connectome in neurodegenerative and
neuropsychiatric disease. The unit also oversees
the development and research extension of
the Australian Child and Adolescent Trauma,
Loss and Grief Network (ACATLGN). Ongoing
collaborations with Mental Health, Justice Health
and Alcohol and Drug Services have led to a
range of embedded research projects with a
focus on trauma, posttraumatic stress disorder
and its transgenerational impacts. These projects
have a strong clinical focus, with an emphasis
on supporting clinicians through education and
supervision in evidence-based treatments. We are
also conducting research into suicide in the ACT
and contributing factors. Furthermore, four of our
postgraduate students have recently graduated,
including Dr Matthew D Macfarlane (MPhil, ANU);
Mr Conor Owens-Walton [MNeurosci(Research),
ANU]; Dr Rosa Molina-Ruiz (PhD Cum Laude,
Complutense University Madrid); and Dr Fiona
Wilkes (MChD) an ongoing PhD scholar.
Staff
Professor Beverley Raphael, Professor and Head of
Psychiatry and Addiction Medicine
Associate Professor Jeffrey Chee Leong Looi,
Deputy Head and Director, Research Centre for
the Neurosciences of Ageing
Dr Daniel Bonner, Lecturer
Dr Jeffery Cubis, Senior Lecturer
Dr Philip Keightley, Fellow and Associate Lecturer
Associate Professor Rajeev Kumar, Senior
Staff Specialist, CL Psychiatry Unit and
Neuropsychiatry Clinics, Canberra Hospital
Dr Virginia McAndrew, Lecturer
Dr Paul Maguire, Clinical Lecturer
Dr Peter Norrie, Director of Clinical Services and
Chief Psychiatrist Mental Health, Justice Health
and Alcohol and Drug Services
Dr Raj Parige, Senior Specialist, Clinical Director
Alcohol and Drug Services, ACT Health
Dr Rebecca Reay, Senior Research Coordinator
Dr Jaya Reddy, Senior Lecturer
Dr Michael Tedeschi, Clinical Senior Lecturer
Dr Diana Tracy, Clinical Lecturer
Dr Melanie Jones (Fellow – Until March 2014)
Ms Velissa Aplin, Research Officer
Dr Alison Gee, Senior Research Officer
Ms Nicola Palfrey, Research Officer
Students
Dr Paul Maguire, PhD, Australian National University
Supervisor: Professor Beverley Raphael
Dr Fiona A Wilkes, MChD-PhD, Australian National
University
Supervisor: Associate Professor Jeffrey CL Looi
26
Dr Matthew D Macfarlane, MPhil student –
graduating 2014, Australian National University
Mr Mitchell Hunter-Dickson, MChD, Australian
National University
Mr Conor Owens-Walton, Master of Neuroscience
Ms Lena Lujing Liu, MBBS, Australian National
University
Mr Michael Woodward, PhD, Australian National
University
Ms Margaret Moreton, PhD, Australian National
University
Ms Maree Livermore, PhD, Australian National
University
Dr Rosa Molina-Ruiz, PhD – Graduated “cum laude”
2014, Complutense University, Madrid Spain
Mr Jae-Gon Yoo, MChD-MPhil, Australian National
University
Ms Lauren Turner, PhD (Psychology), Australian
National University
Ms Carla Borg-Caruana, BSc, Australian National
University
Ms Suhaila Kamrani, MChD, Australian National
University
Dr Bjorn Cartledge, M Affective Neuroscience,
Universities of Maastricht & Florence
Mr Sam Norman, MChD, Australian National
University
Ms Sandy Ye-Gi Kim, BSc, Australian National
University
Ms Daniella Bulic, PhD, University of New South Wales
Collaborators
Dr Melanie Taylor, Dr Garry Stevens, Professor
Louisa Jorm, Centre for Health Research, School
of Medicine, University of Western Sydney
Dr Zhang Cheng, Dr Ning Ma, Dr Lei Yang, Peking
University, Beijing, China
Professor Nick Talley, Dr Natasha Koloski, University
of Newcastle NSW
Ms Lainie Hart, Neuropsychology, Mental Health
Services, MHJHADS
Dr Carolyn Deans, Professor Anne Buist, Victoria
University, Melbourne
Professor Kay Wilhelm, ‘Faces in the Street’:
St Vincent’s Hospital and Dept of Psychiatry,
UNSW, Sydney
Graduations
Dr Rosa Molina-Ruiz, PhD cum Laude, Complutense
University, Madrid
Dr Matthew D Macfarlane, MPhil, Australian
National University
Mr Conor Owens-Walton, MNeurosci (Research),
Dr Fiona A Wilkes, MChD (Doctor of Medicine and
Surgery), Australian National University
Visitors
Professor Brian D Power, University of Notre Dame,
Fremantle, WA
Associate Professor Mark Walterfang, University of
Melbourne, Melbourne, Australia
Associate Professor Michael Bennett, University of
New South Wales, Sydney, Australia
Research projects
Project title: Suicide and Contributing Factors in
the Australian Capital Territory
Principal investigators: B Raphael, A Gee
Funding source: ACT Health
Project title: Investigation of 3 Dimensional Shape
Analysis – ENIGMA-ND
Principal investigators: B Gutman, S Madsen,
J Looi, M Walterfang, D Velakoulis, L-O Wahlund,
P Thompson
Project title: Development and Validation of
Cerebellar Segmentation for Structural MRI in PSP
Principal investigators: E Schofield, J Looi,
D van Westen, C Nilsson, S Ye-Gi Kim
Project title: Cognitive and Psychosocial
Assessment of Mechanically Ventilated Intensive
Care Patients: Does an Experience of Delirium
make a Difference?
Principal investigators: D Bulic, F van Horen, J Looi,
M Bennett, H Rodgers
27
Project title: Hippocampal Morphology in
Temporal Lobe Epilepsy
Principal investigators: J Looi, D van Westen,
K Kallen, J-G Yoo
Project title: Investigation of 3 Dimensional Shape
Analysis in the IMAGE-HD Cohort
Principal investigators: J Looi, F Wilkes, L Turner,
M Walterfang, D Velakoulis, D Apthorp,
N Georgiou-Karistianis
Project title: Longitudinal Volumetry of the
Striatum in a Cohort with Leukoaraiosis – A Pilot
Study
Principal investigators: J Looi, M Macfarlane,
M Walterfang, G Spulber, M Crisby, LADIS study
group
Project title: Manual Segmentation of the Striatum
and Thalamus in Progressive Supranuclear Palsy and
Controls
Principal investigators: M Hunter-Dickson, B Power,
J Looi, M Macfarlane, C Nilsson, D van Westen,
C Borg-Caruana
Project title: Automated Segmentation of the
Corpus Callosum in Frontotemporal Lobar
Degeneration
Principal investigators: J Looi, C Adamson,
M Walterfang, D Velakoulis
Project title: Study of the Morphometrics and
Correlates of the Neostriatum in Bipolar Disorder
Principal investigators: B Cartledge, J Looi,
M Walterfang, D Velakoulis, C Wijeratne
Correlates of the Neostriatum in Parkinson’s
Disease
Principal investigators: C Owens-Walton,
J Looi, M Walterfang, D Velakoulis, D van Westen,
O Hansson
Correlates of the Neostriatum in Parkinson’s
Disease: Clinical Translational Tools
Principal investigators: J Looi, M Walterfang,
D Velakoulis, F Wileks, S Varma, B Hayhow, F Gaillard,
S Starkstein
Correlates of the Neostriatum and Thalamus in
Behavioural Variant Frontotemporal Dementia
Principal investigators: A Santillo, M Macfarlane,
B Power, J Looi, M Walterfang, D Velakoulis,
D van Westen, C Nilsson
Project title: Improving the Delivery of Child and
Adolescent Mental Health Services to Children and
Young People who have been Exposed to Trauma
and Adversity
Principal investigators: B Raphael, R Reay,
V McAndrew, J Cubis, D Riordan, W Preston
Funding source: Canberra Hospital Private Practice
Fund
Project title: Improving Mental Health Outcomes
through the Implementation of a Trauma-Focussed
Model of Care in a Child and Adolescent Mental
Health Setting
Principal investigators: B Raphael, R Reay,
N Palfrey, V McAndrew, J Cubis, D Riordan
Fund
Project title: The Prevalence and Course of
Trauma and Posttraumatic Stress Disorder
Symptoms in Mothers Attending a Perinatal Mental
Health Service
Principle investigators: R Reay, B Raphael, J Cubis,
C Ringland, K Carnall, R Morrison
Fund
Project title: Emotional Regulation in Eating
Disorders
Principal investigators: R Molina-Ruiz, J Looi,
M Diaz-Marsa, F Wilkes, L Lujing Liu
Project title: Correlates of a Single-Item Measure
of Self-Rated Mental Health
Principal investigator: P Maguire
Fund
Project title: What People Think Caused Their
Mental Illness – A Qualitative Study
Principal investigator: P Maguire
Fund
Project title: Opiod Maintenance Treatment in
Pregnancy and Neonatal Abstinence Syndrome:
A Retospective Observational Staudy at Canberra
Hospital
Principal investigator: R Parige
Project title: Clinical Characteristics and
Outcome in a Series of Patients with Psychogenic
(Conversion) Movement Disorders in a
Neuropsychiatry Clinic
Principal investigators: R Kumar, C Lueck
Project title: Psychosocial Impacts Associated with
Domestic Water Restrictions
Principal investigator: M Woodward
28
Project title: Community Recovery after Natural
Disaster
Principal investigator: M Moreton
Project title: Psychiatric Clinicians Engagement with
Mental Health Law in Practice
Principal investigator: M Livermore
Project title: What Is Happening at the Seclusion
Review that makes a Difference?
Principal investigators: B Raphael, B Foxlewin
Project title: Fatigue in Inflammatory Bowel
Disease Study
Principal investigator: P Keightley
Awards
RANZCP New Investigator Grant 2013
Dr Fiona A Wilkes
Parkinson’s ACT Medical Student Travel
Scholarship 2013
Dr Fiona A Wilkes
RANZCP Early Career Psychiatrist Career Award
2014
Dr Matthew D Macfarlane
Best Presentation MBBS Project Night 2014
Mr Jae-Gon Yoo
Scholarship 2012–2013
Mr Jae-Gon Yoo
Ms Sandy Ye-Gi Kim
Ms Carla Borg-Caruana
Ms Suhaila Kamrani
JCSMR Master of Neuroscience Research
Scholarship 2014
Mr Conor Owens-Walton
Mr Conor Owens-Walton
Best Poster Award, World Congress of Internal
Medicine, Seoul, Korea 2014
Associate Professor Rajeev Kumar
Grants
Recipient: B Raphael
Project title: Suicide and Contributing Factors in the
Australian Capital Territory
Grant amount: $148,089 per annum
Recipients: B Raphael, D Riordan, W Preston,
J Cubis, R Reay, V McAndrew
Fund
Project title: Improving the Delivery of Child and
Adolescent Mental Health Services to Children and
Young People who have Been Exposed to Trauma
and Adversity
Recipients: B Raphael, V McAndrew, R Reay,
W Preston, J Cubis, D Riordan
Fund
Project title: Improving Mental Health Outcomes
through the Implementation of a Trauma-Focussed
Model of Care in a Child and Adolescent Mental
Health Setting
Recipients: R Reay, B Raphael, J Cubis, C Ringland,
K Carnall, R Morrison
Fund
Project title: The Prevalence and Course of Trauma
and Posttraumatic Stress Disorder Symptoms
in Mothers Attending a Perinatal Mental Health
Service
Recipient: P Maguire
Fund
Project title: Understanding how People with
Schizophrenia View Influenza – A Qualitative Study
Grant amount: $500
Recipients: J Chan, X Gwee, K Ee Heok, N Tze Pin,
D Jeste, B Raphael, R Kumar
Funding source: National University of Singapore
Project title: Spirituality in Successful Ageing: Data
from the Singapore Study of Successful Ageing
(SSOSA)
Grant amount: SGD 20,000
29
The Anatomical Pathology research group has a
diverse range of research interests largely as a result
of its collaboration with other research teams.
A key focus in the group is cancer biology and
management, particularly related to breast cancer.
Staff
Associate Professor Sanjiv Jain, Director Anatomical
Pathology and Senior Staff Specialist
Dr Genevieve Bennett, Senior Staff Specialist
Dr Michael Brown, Senior Staff Specialist
Dr Maya Cherian, Senior Staff Specialist
Professor Jane Dahlstrom, Senior Staff Specialist
Dr Lavinia Hallam, Senior Staff Specialist
Dr Huw Llewellyn, Senior Staff Specialist
Dr Millie Lui, Senior Staff Specialist
Dr Mitali Fadia, Staff Specialist
Dr Alex Currie, Academic Fellow in Anatomical
Pathology, ANU Medical School
Dr Mark Koina, Electron Microscopist
Ms Sabine Grunger, Scientist
Ms Elaine Bean, Scientist
Mr Arin Chandra, Scientist
Ms Kirsti Harrington, Scientist
Ms Rhiannon Kelly, Scientist
Mr Oliver Campos, Scientist
Ms Amanda Bullman, Senior Scientist,
Immunohistochemistry
Students
Dr Ramindhu Galgamuwa Arachchige, PhD, JCSMR
Supervisors: Professor Jane Dahlstrom
(advisory panel), Professor Philip Board
Ms Christina Salmon, PhD, Australian National
University
(advisory panel), Dr Aude Fahrer
Dr Carina Bertoldi Franco, PhD, ANU Medical
School
(advisory panel), Professor Chris Nolan
Grants
Recipients: J Dahlstrom, S Rao
Project title: Epigenetic Regulation by Lysine
Specific Demethylases in Breast Cancer Stem Cells
Grant amount: $571,894 (3 years)
Recipients: J Dahlstrom, D Rangasamy
Project title: Understanding the Role of
Endogenous Sirnas in the Maintenance of Repetitive
Elements
Funding source: ARC
30
Recipients: J Dahlstrom, V Delghingaro-Augusto
Project title: The role of Iron in Inflammatory Islet
Injury
Funding source: Diabetes Australia Research Trust
Recipient: J Dahlstrom
Project title: Can Daily 670nm Red Light Therapy
Reduce the Incidence and Severity of Retinopathy
of Prematurity in Premature Babies Less Than 30
Weeks Gestation?
Fund
Project title: Breast Tissue Bank
Funding source: Radiation Oncology Private Practice
Trust Fund
Project title: Health Risk Factors in Childhood
Following Preterm Delivery
Fund
Grant amount $82,000
Project title Understanding and Targeting Metabolic
Regulators of Cancer Cell Proliferation and Death
Funding source: Cancer Council ACT
Project title: The Role of Iron in Inflammatory Islet
Injury
31
Canberra Sexual Health Centre
Canberra Sexual Health Centre (CSHC) is currently
or has recently been involved in several research
and quality improvement activities.
Our current research studies include:
l
Study Site for the Factors associated with the
failure of Anti-Retroviral Therapy (ART) in HIVinfected adults (The PAART study) coordinated by
Professor Andrew Carr of St Vincent’s Hospital
Sydney. This two-year multi-centred prospective
cohort study aims to identify patient, treatment,
and socio-economic factors that increase the
risk of patients ceasing or interrupting their ART.
CSHC has enrolled 21 patients.
l
The Chlamydia in Women study is a prospective
cohort study that aims to determine if women
who test positive for vaginal chlamydia also have
rectal chlamydia. CSHC is currently recruiting
patients.
l
Study site for the upcoming National Cross
Sectional Study of Women Living with HIV in
Australia, coordinated by Associate Professor
Michelle Giles of Royal Women’s Hospital.
CSHC aims to start recruiting patients in 2015.
l
Assessing Health Literacy in ACT Health
Outpatient Clinics. CSHC aims to start
recruiting patients in 2015.
Our achievements in 2013–2104 include:
l
2014 Introduction of the MClinic (for men who
have sex with men): Winner of ACT Health’s
Better Practice Awards (Clinical Division
Category) and Winner (Consumer Participation
Category) in ACT Quality in Healthcare Awards
l
2013 Canberra Sexual Health Centre 2013 Client
Satisfaction Survey: Finalist in ACT Health’s Better
Practice Awards
l
2013 Improvement of Contact Tracing at CSHC:
Finalist in ACT Health’s Better Practice Awards
Our quality improvement activities 2013–2014:
l
Enhanced Chlamydia Screening in Antenatal and
Gynaecology services, Centenary Hospital for
Women and Children at Canberra Hospital
l
Screening of asymptomatic MSM who
disclose high risk behaviour (Clinical audit in
conjunction with the Joanna Briggs Institute,
University of Adelaide)
Introduction and conduct of an Out-Of-Hours
MClinic (for men who have sex with men)
l
24 hr HIV SMS result for MSM 2014
l
Medication Standing Orders Review 2014
l
Management of Pelvic Inflammatory Disease
2013–14
l
Development of a Medical Student Orientation
video 2013
l
Improving Contact Tracing at CSHC 2013
l
Patient Satisfaction Survey 2013.
l
Staff
Dr Sarah Martin, Senior Staff Specialist and Director
CSHC; Senior Lecturer, ANU Medical School
Dr Alex Tyson, Staff Specialist CSHC; Senior Lecturer,
ANU Medical School
Dr Marian Currie, Acting Director, Research Centre
for Nursing and Midwifery Practice; Adjunct
Associate Professor, University of Canberra and
the Medical School; CMBE, Australian National
University
Mr Rendry Del Rosario, Clinical Nurse Consultant
CSHC
Dr Miranda Sherley, CSHC Registrar
Ms Shannon Woodward, CSHC Nurse Practitioner
Ms Anne Baynes, CSHC Sexual Health Nurse
Ms Ruth Evans, CSHC Sexual Health Nurse
32
Students
Ms Kate Musil, MBBS, ANU Medical School
Supervisors: Dr Sarah Martin, Dr Marian Currie
Grants
Recipient: A Baynes
Funding source: The Joanna Briggs Institute
Evidence-Based Clinical Fellowship Program
Project title: Adherence to Recommended
Australian Sexually Transmitted Infections
Screening Guidelines among Asymptomatic Men
Who Have Sex with Men at an Australian Capital
Territory Sexual Health Center: A Best Practice
Implementation Project
Cancer Immunology
This research period is the final for Cancer
Immunology Research, which ceased operations in
December 2014.
Cancer Immunology Research started as the Cancer
Research Unit led by Dr Hilary Warren in February
1979. This was the first dedicated research group
established at what was then the Woden Valley
Hospital. The aim of the Cancer Research Unit was
to apply fundamental knowledge gained in mouse
studies, to understanding the immune responses to
human tumours. Collaborations were established
with the Oncology Unit at the hospital, and with the
Department of Clinical Sciences, John Curtin School
of Medical Research that was based at the hospital
in the early years. Several collaborations nationally
and internationally were established, in particular
those with Professor Chris Parish (JCSMR) and
Professor Lewis Lanier (University of California at
San Francisco) that were active over several decades.
The major focus of research was human Natural
Killer (NK) cells, after our important discovery
published in 1984 that NK cells could be generated
by culture in vitro. Research involving mouse models
in transplantation biology continued in parallel with
human T lymphocyte studies in the early years. The
Cancer Research Unit was actively involved in studies
defining human leucocyte antigens with monoclonal
antibodies (the CD nomenclature) through
participation in the International Workshops on
Human Leucocyte Antigens. Understanding receptors
that regulate human NK cell proliferation and function
was the core of our research. In 2013–2014, studies
were completed on an assay for measuring NK cell
function on cells isolated from human peripheral
blood that has important clinical applications.
Research was funded through major grants and
fellowships from the National Health and Medical
Research Council of Australia, with essential support
from the Private Practice Fund at Canberra Hospital,
and other smaller funding bodies. A total of $4.3
million in grants were awarded over the 35-year
period. From this research there were 59 papers
published in refereed journals, in addition to
conference proceedings and published abstracts.
Staff
Dr Hilary S Warren, Head of Cancer Immunology
Research; Visiting Fellow, JCSMR and ANU
Medical School
Collaborators
Dr Peggy Horn, Australian Institute of Sport,
Canberra
Professor David Pyne, Australian Institute of Sport
Dr Nicholas West, Griffith University, Queensland
Professor Allan Cripps, Griffith University,
Queensland
Research projects
Project title: A Study of Probiotics and Immune
Function in Healthy Athletes
Principal investigator: N West
Funding source: Griffith University Grant
33
34
Relative to blood transfusion
practices for medical purposes
dating back to the 1800s, the
use of blood in a civilian, prehospital setting is relatively
recent in the management of
the haemorrhaging patient. Most
deaths resulting from trauma
occur within one hour of injury,
highlighting the importance of
early intervention. Indeed, it has
recently been demonstrated
that receiving a pre-hospital
transfusion (PHT) can be
associated with a 95 per cent
reduction in 24‑hour mortality.
The link between helicopter
emergency medical services
(HEMS) intervention and reduced
patient mortality nationally and
internationally is well documented, although there
are studies that indicate this may not always be so.
However, the large majority of research on prehospital transfusions to date appears to stem from
urban‑based retrieval services with shorter response
times to and from a definitive care facility.
In Australia, HEMS have been operating since the
early 1970s, and The Capital Region Retrieval
Service (CRRS) is based in the Australian Capital
Territory, but services an area greater than 125,000
square kilometres. The Snowy Hydro SouthCare
helicopter of the CRRS has provided a retrieval
and aeromedical rescue service to the ACT and
southern New South Wales since 1998. It was
originally a paramedic-based service, but transitioned
to a physician-paramedic model in 2008. While the
advantage of the inclusion of physicians in HEMS
teams is still debated, perhaps most poignantly
highlighted by the fact that a physician is only present
in approximately 5 per cent of the United States
HEMS, the general consensus is that their addition
is associated with increased patient survival. As a
physician-staffed HEMS, the CRRS offers a unique
opportunity to explore the role of pre-hospital
transfusions (PHTs) outside the metropolitan realm
given the extended distances it services.
The aims of our research were to (i) ascertain
the frequency of PHTs undertaken by the CRRS
between January 2011 and January 2015; (ii) assess
the clinical triggers employed to do so; and (iii)
evaluate the appropriateness of the PHTs.
Our hypothesis is based on the following: (i) the
carriage of pre-packaged red blood cell (pRBC) is
justified; (ii) the current CRRS standard operating
procedures for PHT are appropriate, and (iii) the
CRRS is not over-transfusing.
Staff
Dr Kelvin Grove, Senior Specialist, Intensive Care Unit
Dr Simon Robertson, Consultant
35
Cardiac Rehabilitation
The Cardiac Rehabilitation
Unit of Canberra Hospital and
the Heart Foundation are at
present undertaking research
in Consumer engagement
and participation in cardiac
rehabilitation. This research has
three surveys that patients are
asked to fill out. Survey one is
given to patients on completion
of the six-week program, survey
two is given to patients who
don’t complete the six-week
program, and survey three is
sent to patients who decline
to participate in the six-week
program. The information
provided by the patients is then
used by the Canberra Hospital Cardiac Rehabilitation
Unit and the Heart Foundation to assist in
understanding what the motives are for completing a
cardiac rehabilitation program, what inhibits patients
from completing the program and finally, what
prevents them from participating. This survey will also
help to gain some insight into the heart health needs
of heart patients. This survey contains 40 questions
asking the patients about their demographics, their
first experience of cardiac rehabilitation in hospital,
their state of health and changes to their lifestyle since
their heart attack. This survey commenced April 2014.
Staff
Ms Margaret Flaherty, Clinical Nurse Coordinator
Ms Carmel Bumpus, Registered Nurse
Ms Donella Proud, Registered Nurse
Ms Michelle Lander, Registered Nurse
Ms Jane Colman, Registered Nurse
Ms Karen Butcher, Registered Nurse
Ms Zainab Alosi, Registered Nurse
Grants
Recipient: Cardiac Rehabilitation
Funding source: National Heart Foundation
Project title: Consumer Engagement
36
Centre for Advances in Epidemiology and IT
The main focus of the Centre for Advances
in Epidemiology and IT has been the creation
of a sustainable growth model for knowledge
generation in healthcare that has both discovery
and efficiency as the primary drivers. Known as
Turning Research into Practice (TRIP), the program
has a three-tier approach incorporating: 1) the
research process; 2) generation of predictive
models to improve individual patient outcomes;
and 3) a focus on efficient service delivery using an
evidence-based model.
Flagship projects have produced outstanding results.
The CPAP Weaning Trial, involving the Canberra
Hospital’s Neonatal Intensive Care Unit (lead Dr
David Todd), Westmead Hospital and Royal Brisbane
Hospital, provided strong evidence for a superior
method in the weaning of pre-term babies off
CPAP (now called CICADA). The findings were
published in the Archives of Childhood Diseases
and ran as the lead article in the July 2012 edition.
The project was further honoured with the 2011
ACT Quality Award for Innovative Care. Similar
successes have emerged in orthopaedics around
joint replacement, respiratory and sleep medicine
in CPAP acclimatisation, gastroenterology in chronic
liver disease, understanding the needs of people
living with multiple sclerosis, macular hole and
retinal detachment surgery (2014 winner of ACT
Quality Award for Systems Support), and nursing
management around pressure injuries and more
broadly tissue viability.
Staff
Dr Bruce Shadbolt, Director, Centre for Advances in
Epidemiology and IT
Associate Professor Jan Sansoni, Director, Australian
Health Outcomes Collaboration
Students
Research projects
Project title: Cardiovascular, Renal and Metabolic
Risk Factors in Childhood Following Preterm
Delivery with Maternal Diabetes and Hypertension
Principal investigators: B Shadbolt, A Kent
Fund
Project title: TLR9 in NASH Pathogenesis: Roles
in Macrophages, Hepatocytes and White Adipose
Tissue Inflammation
Principal investigators: B Shadbolt, G Farrell,
C Nolan
Awards
Ms Ruiduan Wang, PhD, Australian National
University
Supervisor: Dr Bruce Shadbolt
2014 ACT Quality Award for System Support
Associate Professor Rohan Essex and
Dr Bruce Shadbolt
Ms Jessica Penney, BSc, Australian National University
Supervisor: Dr Bruce Shadbolt
ANU Sports Blue Award (Athletics)
Ms Jessica Penney
37
Chemical Pathology
Departmental research is focused on the
use of high sensitivity assays for cardiac
troponin I. The heart molecule troponin I
is an important element in the diagnosis
of myocardial infarction. With the very
new assays – so called high-sensitivity
assays – for cardiac troponin I, we have
shown that this molecule is present at
low concentration in the blood of healthy
children and adults. Our research has
focused on defining the significance of
these low concentrations and how to
use these new assays in the Emergency
Department and other sites where
measurement of troponin I is being used to
define cardiac disease.
The Department of Chemical Pathology also has a
close involvement with the Department of Diabetes
and Endocrinology, and a number of small studies
have been performed in areas of common interest in
diabetes and general endocrinology.
Staff
Dr Peter E Hickman, Director of Chemical
Pathology; Associate Professor, ANU Medical
School
Professor Julia M Potter, Senior Staff Specialist
Dr Marie M Salib, Registrar in Chemical Pathology
Dr Emma Southcott, Research Scientist
38
Chief Allied Health Office
The Chief Allied Health Office is the strategic allied
health professional lead for ACT Health’s allied
health workforce, representing over 25 allied health
disciplines. The Chief Allied Health Office supports
clinical education and research activities across
allied health areas. The Chief Allied Health Office is
particularly interested in research that:
l
promotes interprofessional learning and
collaborative practice
l
involves a clinical service or clinical education focus.
The diversity of allied health professions at
ACT Health offers great potential for research
partnerships to explore a wide variety of areas.
The Chief Allied Health Office supports this
by providing research support grants to key
research collaborations being led by allied health
professionals at ACT Health. Since 2013, the Chief
Allied Health Office has provided grants towards
research on topics such as:
l
Does bed realignment and staff deployment
change compliance with tracheostomy safety
equipment and observation charts?
l
Is the ‘Acute Care Index of Function’ Tool a
reliable and valid measure of physical function in
ICU patients?
Management of Hip Dysplasia at Centenary
Hospital for Women and Children
l
Assessing the health outcomes of the
‘Active Couch Potato’ Phenomenon among
cardiac patients attending a Phase II Cardiac
Rehabilitation Program: An International
Collaboration Approach
l
What are the long-term outcomes of Intensive
Care Unit survivors? Is there a need for followup and screening for multi-disciplinary care
following discharge home?
l
Increasing physiotherapy treatment time for
stroke patients in acute care at Canberra
Hospital and Health Services
l
Can Advanced / Extended Scope Physiotherapists
provide an alternative, cost-effective safe model
of care for post-operative arthroplasty review
appointment – A scoping project
l
Does adding Inspiratory Muscle Training to a
Pulmonary Rehabilitation Program improve
patient-centred outcomes – A pilot feasibility study
l
Chronic kidney disease and exercise: Literature
review and service benchmarking
l
Can a simulation-based learning tool enhance
teaching of ventilation hyperinflation skills in
Intensive Care
l
39
Gel Dosimetry for Verification of Stereotactic
Radiotherapy of multiple targets using a single
isocenter
l
The importance of the Six-Minute Walk Test
in the Canberra Hospital and Health Services
Cardiac Rehabilitation Program
l
Quality control in Digital Radiography
l
Radiation Dose Survey of neonates at Canberra
Hospital.
l
If you would like to know more about research
involving allied health areas at ACT Health the
Chief Allied Health Office can assist.
Staff
Ms Karen Murphy, Chief Allied Health Officer
Ms Sally Ranford, Allied Health Project Officer
Ms Leanne Pagett, Allied Health Assistant Clinical
Development Coordinator
Mr Ned Jelbart, Interprofessional Learning
Coordinator
Ms Jennie Yaxley, Allied Health Clinical Education
Coordinator
Ms Gesima Olney, Acting Social Work Clinical
Educator
Ms Katie Cole, Occupational Therapy Clinical
Educator
Ms Emily Peelgrane, Occupational Therapy Clinical
Educator
Mrs Nicola Wardrop, Speech Pathology Clinical
Educator
Ms Annette Carroll, Clinical Measurement Sciences
Clinical Educator
Ms Marion Swetenham, Psychology Clinical Educator
Ms Meryl Williams, Student Placement Officer
Mr Patrick Wells, Project Officer – Credentialing and
Scope of Clinical Practice
Ms Alison Lancaster, Project Officer – Clinical
Supervision
Dr Debra Harris, Project Officer – Counsellor
Workforce
Research projects
Project title: Longitudinal Placements in Speech
Pathology
Principal investigator: N Wardrop
This project investigated the learning and placement
satisfaction outcomes of longitudinal placements
for speech pathology students by analysing the
themes arising from post-placement interviews with
students. Ethics approval: ETHLR.13.172
40
Chronic Disease Management
Chronic Disease Management (CDM) is a
multidisciplinary unit of the Division of Medicine in
Canberra Hospital and Health Services (CHHS).
The focus of CDM is on improving the management
of patients with chronic disease, particularly
chronic obstructive pulmonary disease (COPD),
chronic heart failure (CHF), Parkinson’s disease and
obesity. We also undertake project work including
management consulting, clinical audits, continuous
quality improvement, research activities and
evaluations to improve the management of chronic
disease across the ACT.
CDM comprises the Chronic Disease Management
Unit, the Obesity Management Service and the
Chronic Care Program. It also works in close
collaboration with the ANU Centre for Health
Stewardship.
Our key projects are:
l
Home monitoring of chronic disease for aged care
l
E-health and regional integration of primary and
referral-based care for patients with chronic
disease
l
Optimising the information design of clinical
repositories for local hospital networks
l
Public views about Australia’s health system
Time and chronic disease management
l
The place of cultural competence in successful
citizen engagement for policy making in the
public sector
l
The products of dairy farms: a potential threat
to public health in Lahore, Pakistan.
l
Staff
Associate Professor Paul Dugdale, Director
Dr Belinda Jones, Chronic Disease Management
Registrar
Dr Peter Loa, Chronic Disease Management
Registrar
Dr Sabrina De Bellis-Ayres, Chronic Disease
Management Registrar
Dr Kristen Murray, Obesity Management Service
Psychologist
Dr Andrew Mathieson, Lecturer, Centre for Health
Stewardship
Ms Claire Pearce, Senior Project Officer
Ms Tanelle Raines, Project and Research Officer
Ms QingQing Liu, Project and Research Officer
Ms Genevieve Hopkins, Project and Research
Officer
Ms Sally-Anne Wherry, Parkinson’s Disease and
Movement Disorders Clinical Nurse Consultant
Ms Jan Ironside, Chronic Care Program Manager
41
Students
Ms QingQing Liu, PhD, Australian National
University
Supervisor: Associate Professor Paul Dugdale
Ms Lily Shao, PhD, Australian National University
Ms Catherine Settle, PhD, Australian National
University
Ms Cathy Clutton, PhD, Australian National
University
Ms Nami Matsumoto, PhD, Australian National
University
Co-Supervisor: Associate Professor Paul Dugdale
Ms Yodi Christiani, PhD, Australian National
University
Co-Supervisor: Associate Professor Paul Dugdale
Ms Jodette Kotz, Masters of Public Health
Mr Muhammad Waqas, Masters of Public Health
Graduations
Ms Sally-Anne Wherry, Masters of Management of
Parkinsons, Leeds Beckett University
Ms Jodette Kotz, Masters of Public Health
Mr Klein Fernandes, Masters of Public Health
Ms Dang Ni (Janice) Lee, Masters of Public Health
Visitors
Dr Bahareh Tahani, University of Tehran
Research projects
Project title: Home Monitoring of Chronic Disease
for Aged Care
Principal investigator: B Celler
Funding source: Department of Health and Ageing,
Department of Broadband, Communications and
the Digital Economy
Project title: E-Health and Regional Integration of
Primary and Referral Based Care for Patients with
Chronic Disease
Principal investigator: Q Liu
Funding source: Australian National University,
ACT Health
Project title: Optimising the Information Design of
Clinical Repositories for Local Hospital Networks
Principal investigator: Ms Yunli Shao
Funding source: Australian National University,
ACT Health, National ICT Australia
Project title: Public Views about Australia’s Health
System
Principal investigator: C Settle
Funding source: ACT Health, Queensland Health,
South Australia Health, Australian Research Council
Project title: Time and Chronic Disease
Management
Principal investigator: P Dugdale
Funding source: Australian National University
Project title: The Place of Cultural Competence in
Successful Citizen Engagement for Policy Making in
the Public Sector
Principal investigator: C Clutton
Project title: The Products of Dairy Farms:
A potential threat to public health in Lahore,
Pakistan
Principal investigator: Mr Muhammad Waqas
Funding source: Australian National University
42
Clinical Trials Unit
The Clinical Trials Unit conducts, coordinates and
manages a diverse range of quality clinical trials at
the Canberra Hospital.
The unit is involved in up to 40 active trials in various
stages, from ethics submission to trial closeouts. The
portfolio of clinical trials conducted in the unit vary
between Phase I to Phase IV Studies in the disciplines
of Cardiology, Geriatrics, Paediatrics, Endocrinology,
Gastroenterology, Hepatology, Immunology,
Rheumatology, Infectious Diseases, Ophthalmology,
Anaesthesiology, Respiratory and Neurology.
The unit employs more than 20 Clinical Trials
staff with experience in medicine, nursing, clinical
and non-clinical research, management, finance,
operational and administrative support. This team
collaborates with the Staff Specialists as either
Principal Investigators or Sub-Investigators on all
clinical trials and projects conducted.
Patients are enrolled from the Canberra District
and Southern New South Wales. Over recent
years, thousands of patients have participated in
and benefited from access to emerging treatments
and improved clinical practices through research
conducted in the Clinical Trials Unit.
The unit has a combination of both investigatorinitiated collaborative studies and pharmaceutical
sponsored studies. The unit is participating as one of
the sites for Australia’s largest clinical trial, ASPirin in
Reducing Events in the Elderly (ASPREE) Study, which
has recruited 16,700 participants across Australia.
The unit is also conducting many of the sub studies
that focus on outcomes of Aspirin on neurovascular
imaging, hearing loss, retinal imaging, sleep apnoea,
macular degeneration and the establishment of a
BioBank of healthy ageing Australians.
The unit’s financial independence is underpinned
by funding from the NHMRC, Australian
Sports Commission and Canberra Hospital
Private Practice Fund and income derived from
pharmaceutical sponsored studies. Many of the
Investigator initiated projects are in collaboration
with the following institutions: Australian National
University, University of Canberra, Monash
University, University of Tasmania, University of
Adelaide and the South Australia Health and
Medical Research Institute (SAHMRI).
Staff
Professor Walter Abhayaratna, Director, Clinical Trials
Unit
Ms Katherine Johnson, Clinical Trials Unit Manager
Professor Richard Telford, Clinical Trials Senior
Research Fellow
Dr Wichat Srikusalanukul, Clinical Trials Coordinator
Medical
Dr Zuopeng Wu, Senior Research Officer
Dr Kavitha Velusamy, Research Officer
Ms Heidi West, Finance Support Officer
Ms Cate Revill, Administrative Assistant and
Receptionist
Mr Christian Abhayaratna, Administrative Assistant
Ms Lisa Olive, Psychologist
Mr Rohan Telford, Research Coordinator
Ms Kate Hayes, Cardiac Sonographer
Ms Emily Wilford, Clinical Trials Coordinator
Ms Karen Dzialdowski, Clinical Trials Coordinator
Ms Sarah Kamppi, Clinical Trials Coordinator
Ms Jubbie Varghese, Clinical Trials Coordinator
Ms Chenoa Barton, Clinical Trials Coordinator
Ms Amanda Wylie, Research Officer
Ms Janine Vickers, Clinical Trials Coordinator
Ms Allison Bell, Clinical Trials Coordinator
Ms Jane Rubendra, Clinical Trials Coordinator
43
Ms Divya Babu, Clinical Trials Coordinator
Ms Anthea Oon, Clinical Trials Coordinator
Ms Francesca Rochford, Clinical Trials Coordinator
Ms Michelle Warnock, Clinical Trials Coordinator
Ms Janine Lourensz, Clinical Trials Coordinator
Ms Bev Wilson, Rheumatology and Biologics
Research Coordinator
Ms Biljana Zeljkovic, Rheumatology and Biologics
Research Coordinator
Collaborators
Professor Chris Nolan, Director of Diabetes
Services Endocrinology, Canberra Hospital; ANU
Medical School
Professor Paul Pavli, Senior Staff Specialist
Gastroenterology, Canberra Hospital; ANU
Medical School
Professor Matthew Cook, Director of Immunology
and Translational Research, Canberra Hospital;
ANU Medical School
Dr Anna Dorai Raj, Staff Specialist, Rheumatology,
Canberra Hospital; ANU Medical School
Dr Chandi Perera, Director of Rheumatology,
Canberra Hospital
Professor Paul Gatenby, Senior Staff Specialist
Immunology, Canberra Hospital; ANU Medical
School
Associate Professor Rohan Essex, Staff Specialist
Ophthalmology, Canberra Hospital; ANU Medical
School
Associate Professor Kathleen Tymms, Senior Staff
Specialist Rheumatology, Canberra Hospital; ANU
Medical School
Dr Ken Khoo, Visiting Medical Officer, Canberra
Hospital; ANU Medical School
Dr Andrew Watson, Staff Specialist, Canberra
Hospital
Dr Kavitha Subramaniam, Staff Specialist
Gastroenterology, Canberra Hospital; ANU
Medical School
Dr Arun Gupta, Staff Specialist, Canberra Hospital;
ANU Medical School
Professor Julia Potter, Executive Director, ACT
Pathology, Canberra Hospital; ANU Medical
School
Associate Professor Peter Hickman, Director of
Clinical Chemistry Pathology, Canberra Hospital;
ANU Medical School
Dr Gus Koerbin, Manager of Clinical Chemistry
Pathology, Canberra Hospital
Dr Elizabeth Da Silva, ANU Fellow Immunology,
Canberra Hospital
Associate Professor Robyn Woods, Senior Research
Fellow, School of Epidemiology and Preventive
Medicine, Alfred Hospital, Monash University VIC
Professor Elsdon Storey, Director of Neurology,
Alfred Hospital, Melbourne VIC
Professor John McNeil, Head of School, School of
Epidemiology and Preventive Medicine, Alfred
Hospital, Monash University VIC
Professor Simon Stewart Head of Preventive
Cardiology, Baker IDI Heart and Diabetes
Institute, Melbourne VIC
Professor Thomas Marwick, Director of Menzies
Research Institute Tasmania
Professor David Thompson, Professor of Nursing,
Cardiovascular Research Centre, Australian
Catholic University, Melbourne VIC
Associate Professor James Sharman, Senior Research
Fellow, Menzies Research Institute, Hobart TAS
Professor Prash Sanders, Director, Centre for Heart
Rhythm Disorders, University of Adelaide; Group
Leader of Heart Rhythm Disorders at SAHMRI
Research projects
Project title: Advance On – Action in Diabetes
and Vascular Disease Preterax and Diamicron MR
Controlled Evaluation – Post Trial Observational
Study
Principal investigator: C Nolan
Funding source: The George Institute for
International Health
Project title: ASPREE – Aspirin in Reducing Events
in the Elderly
Funding source: National Institute of Health (NIH);
National Institute of Aging, USA; NHMRC
Project title: ASPREE ENVIS-ion – Aspirin for
the Prevention of Cognitive Decline in the Elderly
(A Neuro-Vascular Imaging Study from ASPREE
Project title: ASPREE Healthy Ageing Biobank –
Funding source: CSIRO
Project title: ASPREE the SNORE-ASA study –
(A Study of Neurocognitive Outcomes, Radiological
and Retinal Effects of Aspirin in Sleep Apnoea)
Project title: ASPREE-AMD (Age-Related Macular
Degeneration) Study
Funding source: Monash University
44
Project title: ASPREE HEARING – HEAring Retinal
Imaging, Neurocognition in older Generations
(Low-Dose Aspirin and Age Related Hearing Loss)
Project title: BALANCED – Anaesthesia Study
Principal investigator: A Watson
Funding source: Monash University through its
Faculty of Medicine, Nursing and Health Sciences
Project title: BASE – Randomized, Double-Blind,
Placebo-Controlled 52-Week Study to Assess
Adverse Events of Special Interest in Adults with
Active, Autoantibody-Positive Systemic Lupus
Erythematosus Receiving Belimumab
Principal investigator: P Gatenby
Funding source: Human Genome Sciences, Inc.
Project title: BP Guide – A Randomised Study to
Determine the Value of Central Blood Pressure for
Guiding Management of Hypertension
Project title: BREVAS – A Phase 3, Multi-Center,
Multinational, Randomized, Double-Blind Study
to Evaluate the Efficacy and Safety of Belimumab
(HGS1006) in Combination with Azathioprine
For The Maintenance of Remission in Wegener’s
Granulomatosis and Microscopic Polyangiitis
Funding source: Human Genome Sciences, Inc.
Project title: CAAN-AF – CRT and AV Nodal
Ablation Trial in AF Patients
Project title: CANVAS-R – A Randomized,
Multicenter, Double-Blind, Parallel, PlaceboControlled Study of the Effects of Canagliflozin
on Renal Endpoints in Adult Subjects with Type 2
Diabetes Mellitus
Funding source: Janssen-Cilag Pty Ltd
Project title: DECLARE – Dapagliflozin Effect
on CardiovascuLAR Events. A Multicenter,
Randomized, Double-Blind, Placebo-Controlled
Trial to Evaluate the Effect of Dapagliflozin 10 Mg
Once Daily on the Incidence of Cardiovascular
Death, Myocardial Infarction or Ischemic Stroke in
Patients with Type 2 Diabetes
Funding source: AstraZeneca Pty Ltd
Project title: Fast 3 – A Phase III Randomized
Double-Blind, Placebo-Controlled Multicenter
Study of Icatibant for Subcutaneous Injection
in Patients with Acute Attacks of Hereditary
Angioedema (HAE) (Protocol No.: HGT-FIR-054)
Principal investigator: M Cook
Funding source: Shire Human Genetic Therapies, Inc.
Project title: Garfield – Prospective, Multi Centre,
International Registry of Male and Female Patients
Newly Diagnosed with Atrial Fibrillation
Funding source: Thrombosis Research Institute
Project title: Glacial – Q4883g: A Phase III,
Multicenter, Randomized, Double-Blind, PlaceboControlled Safety Study of Xolair (Omalizumab)
in Patients with Chronic Idiopathic Urticaria (Ciu)
who Remain Symptomatic Despite Treatment
with H1 Antihistamines, H2 Blockers, and/or
Leukotriene Receptor Antagonists
Funding source: Genentech, Inc.
Project title: HF-SNAPSHOT – To Capture a Real
World Population of Patients with ADHF across a
Broad Spectrum of Hospitals Providing a Range of
Heart Failure Services
Funding source: Victor Chang Cardiac Research
Institute
Project title: Hope 3 – Heart Outcomes
Prevention Evaluation
Funding source: Hamilton Health Sciences
Corporation
Project title: Impress – Intima-Media Thickness
Guidance of Primary Prevention in Relatives of
Individuals with Early Onset Atherosclerosis
Project title: JADW – A Randomized, DoubleBlind, Placebo-Controlled, Phase 3 Study Evaluating
the Efficacy and Safety of Baricitinib (LY3009104)
in Patients with Moderately to Severely Active
Rheumatoid Arthritis who have had an Inadequate
Response to Tumor Necrosis Factor Inhibitors
Principal investigator: A Dorai Raj
Funding source: Eli Lilly Australia Pty Limited
Project title: JADX – A Randomized, Double-Blind,
Placebo-Controlled, Phase 3 Study to Evaluate the
Efficacy and Safety of Baricitinib (LY3009104) in
Patients with Inadequate Response to Conventional
Disease-Modifying Antirheumatic Drugs with
Moderately to Severely Active Rheumatoid Arthritis
45
Project title: JADY – A Phase 3, Multicenter Study
to Evaluate the Long-Term Safety and Efficacy of
Baricitinib in Patients with Rheumatoid Arthritis
(Extension Study for JADX and JADW)
Project title: LOOK Study during Adolescence –
Lifestyle of our Kids
Funding source: Australian Sports Commission,
Grant amount: $100,000 (ASC); $134,578 (PPF)
Project title: Low CBP Study – Targeted LOWering
of Central Blood Pressure in Patients with
Hypertension: a Randomised Controlled Trial
Project title: Macular Hole Project
Principal investigator: R Essex
Fund, Ophthalmic Research Institute of Australia (ORIA)
Project title: Millennium C13008 – A Phase 3,
Open-Label Study to Determine the Long-Term
Safety and Efficacy of Vedolizumab (MLN0002) in
Patients with Ulcerative Colitis and Crohn’s Disease
Principal investigator: P Pavli
Funding source: Millennium Pharmaceuticals Inc.
Project title: Millennium C13008 Denovo –
A Phase 3, Open-Label Study to Determine the
Long-Term Safety and Efficacy of Vedolizumab
(MLN0002) in Patients with Ulcerative Colitis and
Crohn’s Disease
Funding source: Millennium Pharmaceuticals Inc.
Project title: MINERVA – Multidisciplinary INflammatory
Early Rheumatic disease Vascular Assessment
Principal investigator: C Perera
Project title: Propos – Placental Responses to
Obesity and Pregnancy Outcomes
Project title: Safety – Standard vs Atrial FibrillationspEcific managemenT StudY: The SAFETY Study –
A Multi-Centre, Randomised Controlled Trial
Project title: Saril-Ra (Mobility) – A Randomized,
Double-Blind, Placebo-Controlled, Multicentre,
Two-Part, Dose Ranging and Confirmatory
Study with an Operationally Seamless Design,
Evaluating Efficacy and Safety of SAR153191 on
top of Methotrexate (MTX) in Patients with
Active Rheumatoid Arthritis who are Inadequate
Responders to MTX Therapy
Funding source: Sanofi-Aventis Australia Pty Limited
Project title: Saril-Ra-Extend (Ability) – A MultiCenter, Uncontrolled Extension Study Evaluating
Efficacy and Safety of SAR153191 on top of Dmards
in Patients with Active Rheumatoid Arthritis
Funding source: Sanofi-Aventis Australia Pty Limited
Project title: Savor Timi 53 – SAVOR – Saxagliptin
Assessment of Vascular Outcomes Recorded in
Patients with Diabetes Mellitus, a Multicentre,
Randomised, Double-Blind, Placebo-Controlled
Phase IV Trial to Evaluate the Effect of Saxagliptin
on the Incidence of Cardiovascular Death,
Myocardial Infarction or Ischaemic Stroke in
Patients with Type 2 Diabetes
Funding source: AstraZeneca Pty Limited
Project title: Smile – Phase IIa, 2:2:1 Randomised,
Double-Blind, Placebo-Controlled, Parallel Group,
Multi-Centre Clinical Trial to Investigate the Safety,
Efficacy and Pharmacokinetics of Recombinant
Human Soluble Fc-Gamma Receptor Iib (SM101)
for Intravenous Application in the Treatment of
Systemic Lupus Erythematosus (SLE) Patients with
or Without a History of Lupus Nephritis
Funding source: SuppreNol GmbH
46
Project title: Troponin – High Sensitivity Cardiac
Troponin: Is it Present in Blood in Relatively Minor,
Non-Cardiac Illnesses?
Fund
Project title: UCB – 088 – A Phase Iiib,
Multinational, Open-Label, Follow-On Trial to
C87085 Designed to Assess the Long-Term Safety
of Certolizumab Pegol, a Pegylated Fab’ Fragment
of a Humanized Anti_TNF_Alpha Monoclonal
Antibody, Administered at Weeks 0, 2 and 4, and
then every 4 weeks Thereafter, in Subjects with
Moderately to Severely Active Crohn’s Disease
who have Participated in Study C87085
Funding source: UCB Celltech
Project title: Uniti 1 – A Phase 3, Randomized,
Double-Blind, Placebo-Controlled, ParallelGroup, Multicenter Study to Evaluate the Safety
and Efficacy of Ustekinumab Induction Therapy
in Subjects with Moderately to Severely Active
Crohn’s Disease who have Failed or are Intolerant
to TNF Antagonist Therapy
Project title: Uniti 2 – A Phase 3, Randomized,
Double-Blind, Placebo-Controlled, ParallelGroup, Multicenter Study to Evaluate the Safety
and Efficacy of Ustekinumab Induction Therapy
in Subjects with Moderately to Severely Active
Crohn’s Disease
Project title: VIDA – Vascular Inflammatory
Disease Axis
Fund
Project title: Myeloid Lineage-Induced Vascular
Pathology
Fund
47
Community Care Allied Health Services
Community Care (CC) Allied Health
Services undertake evidence-based
research as part of ongoing service
evaluation and development. During
2013‑2014, the CC Nutrition Service and
CC Physiotherapy Service conducted
research activities to assist in informing
practice to vulnerable populations and
design of future service models.
The CC Nutrition Service conducted an
extensive evaluation program to monitor
whether specific target patient groups are
gaining benefit from nutrition programs.
Collaboration between dietitians and
nursing staff was a key element to the
implementation and evaluation of healthy
cooking sessions to substance-dependent
individuals in the ACT Health Withdrawal
Service program.
Two ongoing core group programs,
Heart Fare and Adult Healthy Weight,
are evaluated on an ongoing regular basis
through pre- and post-group patient
surveys, and then six-month post group
telephone interviews with participants. All research
undertaken and surveys used are approved by the
ACT Health Human Research Ethics Committee.
Health professionals are also surveyed to ascertain
areas of improvement.
Results from the evaluation are collated to provide
valuable evidence to monitor effectiveness of the
program. The aim of nutrition education programs are
to promote healthy eating and lifestyle and not focus
on measuring weight or size. The surveys ascertain
the learning and confidence levels of participants,
their individual weight goals and achievement of
those goals.
The cooking skills sessions delivered to clients of the
Withdrawal Unit was funded through the Australian
Government Healthy Communities Initiative. The
research project to evaluate the effectiveness of
the sessions, Evaluation of a Healthy Cooking Skills
Session delivered by Nursing Staff for Withdrawal
Service Patients, was funded from the 2013 Research
Support Grant, Chief Allied Health Advisors Office,
ACT Health.
The CC Physiotherapy Service offers physiotherapy
assessment and treatment from community-based
health centre locations. Prisoners incarcerated in
Alexander Maconochie Centre, ACT, may require
physiotherapy at times, and this can only be
achieved by securely transporting them to attend
appointments on site.
The service manager used funding from the Chief
Allied Health Advisor’s Office Research Support
Grant 2013 to research current practice in other
correctional facilities in Australia, including site visits
to two facilities, NSW and Victoria. Focus groups
with inmates and Correctional Officers provided
further local information and insight. Information
gained through this research was used to scope
the need for an onsite physiotherapy service at
Alexander Maconochie Centre, ACT. The project
work also designed a draft model of care for such a
service that meets best practice and would suit the
needs of prisoners, Hume Health Centre staff and
Correctional Services staff.
48
Staff
Ms Maxine Scicluna, Director Community Care
Program
Ms Kate O’Brien, Dietitian, Community Care
Program
Ms Jo Taylor, Clinical Nurse Consultant, Alcohol and
Drug Services
Ms Kerrie Phelps, Dietitian, Community Care
Program
Mr Michael Salmon, Dietitian, Community Care
Program
Ms Ana O’Rourke, Manager, Community Care
Nutrition Service
Mr Dominic Furphy, Manager, Community Care
Physiotherapy Service
Ms Maree Sullivan, Health Promotion Officer,
Research projects
Project title: A Healthy Cooking Skills Session
Delivered by Nursing Staff for Withdrawal Service
Patients
Principal investigator: K O’Brien
Funding source: Chief Allied Health Advisors
Office Research Support Grant 2013
Project title: Provision of a Physiotherapy Service
at the Alexander Maconochie Centre: A Scoping
Project
Principal investigator: D Furphy
Funding source: Chief Allied Health Advisors
Office Research Support Grant 2013
49
The Division of Rehabilitation, Aged and
Community Care’s Community Care Program
(CCP), Nursing Service provides nursing care
to patients in health centre clinics and in their
home. Over 50 per cent of community nursing
work is wound management, and a large part of
this is the care for chronic wounds, in particular
venous leg ulcers (VLUs). Community nurses
provide care according to the Australian and New
Zealand Clinical Practice Guideline for Prevention
and Management of Venous Leg Ulcers when
managing patients with VLUs. The patient receives
a comprehensive and holistic assessment, a wound
management plan is implemented and compression
bandages are applied until the ulcer heals. The
Clinical Practice Guideline also specifies that
prevention strategies such as continued wearing
of compression stockings reduce the rate of
recurrence of VLUs, and that ongoing monitoring is
essential. The community nursing service identified
a gap in their service, once the ulcer heals the
patients were discharged from the community
nursing service, and referred back to their General
Practitioner for compression stockings. There was
no follow up or ongoing monitoring by community
nurses.
In 2013–2014, a Practice Development Scholarship
was obtained from the ACT Nursing and
Midwifery Office to improve services for patients
with healed VLUs.
A compression stocking clinic was established
where a nurse practitioner assessed and monitored
patients. In collaboration with a community
pharmacist all patients who attended the clinic
were supplied with appropriate stockings, and
all patients received education and support for
ongoing management of their healed VLU for
a period of six months. Approval was obtained
from the ACT Health Human Research Ethics
Committee to collect data on ulcer recurrence
and patient adherence to prevention strategies. The
data showed that follow up care in a compression
stocking clinic where prevention strategies are
discussed, implemented and reinforced is effective in
the prevention of recurrence of VLU.
The compression stocking clinic is ongoing. It is an
extension of the CCP wound management service
and closes the identified gap.
Staff
Ms Maxine Scicluna, Director Community Care
Program
Ms Judith Barker, Nurse Practitioner Wound Care,
Ms Marina Boogaerts, Clinical Nurse Consultant,
Research projects
Project title: Improving Services for Patients with
Recurring Venous Leg Ulcers: A Compression
Stocking Clinic
Principal investigator: J Barker
Funding source: Practice Development Scholarship
from ACT Nursing and Midwifery Office
2013–2014
50
Emergency Department
The Emergency Department is a busy tertiary
service with multiple active research programs
including:
l
ED Process and Flow Research – Internationally
recognised unit and research base including
Canberra Hospital specific and national projects
l
Road Trauma Research
l
Alcohol Use and Misuse Research
l
ACT Hazards Research.
Staff
Associate Professor Drew Richardson
Awards
CHARM 2013 – Professor Guan Chong Award for
the Best Clinical Research Oral Presentation
Associate Professor Drew Richardson,
Dr Michael Hall
Emergency Care Institute Prize for the best
‘Evidence into Action’ paper at the Annual
Scientific Meeting of ACEM 2013
Associate Professor Drew Richardson,
Dr Michael Hall
Best Trainee Paper at Peripheral Hospitals
Emergency Medicine Conference 2014
Dr Wei-Yun Mak
51
Endocrinology and Diabetes
The Endocrinology and Diabetes Department
at Canberra Hospital is involved in investigator
led and pharmaceutical industry sponsored
clinical research. The department also has a very
active basic research laboratory that focuses on
pancreatic islet biology with projects relevant to
both type 1 and type 2 diabetes as well as diabetes
in pregnancy. There is a strong focus on research
training of medical students and postgraduate
research students. The Endocrinology and Diabetes
Department collaborates widely in research across
the Canberra Hospital Campus, the Australian
National University, and research groups interstate
and internationally.
Dr Aaron Simpson, Advanced Trainee in
Endocrinology
Dr Rakesh Mallikajunan, Advanced Trainee in
Endocrinology
Staff
Ms Yan Zhang, MPhil, Australian National University
Supervisor: Professor Christopher Nolan
Associate Professor Dennis Wilson, Director of
Endocrinology
Professor Christopher Nolan, Director of Diabetes
Dr Robert Schmidli, Endocrinologist
Dr Sumathy Perampalam, Endocrinologist
Dr Viviane Delghingaro-Augusto, Senior Research
Scientist
Mr Cameron Kos, Laboratory Technician
Ms Kaori Hana Hanamoto, Laboratory Technician
Students
Dr Tony Huynh, PhD, Australian National University
Dr Carina Bertoldi-Franco, PhD, Australian National
University
Mrs Ainy Khan Hussain, PhD, Australian National
University
Ms Tenzin Dagpo, MPhil, Australian National
University
Supervisor: Dr Viviane Delghingaro-Augusto
Ms Ayumi Hosaka, Masters of Animal Technology,
52
Dr Tehzeeb Zulfiqar, Masters of Public Health,
Mrs Erandi Hewawasam, Honours, Australian
National University
Ms Aimee Davenport, MBBS, Australian National
University
Ms Ramya Velalagan, MBBS, Australian National
University
Ms Donya Tohidi-Esfahani, MBBS, Australian National
University
Mr Haoming Zhuo, MBBS, Australian National
University
Ms Angeline Josiah, MBBS, Australian National
University
Ms Christina Unger, MBBS, Australian National
University
Ms Ayesha Arora, MBBS, Australian National
University
Mr Ben Loel, MBBS, Australian National University
Mr Lachlan Cormick, MBBS, Australian National
University
Ms Jacqui Jones, MBBS, Australian National
University
Mr Justin Friedman, MBBS, Australian National
University
Collaborators
Professor Geoff Farrell, Senior Staff Specialist,
Gastroenterology and Hepatology; Professor of
Hepatic Medicine, ANU Medical School
Professor Jane Dahlstrom, Senior Staff Specialist,
Professor Alison Kent, Senior Staff Specialist,
Neonatology
Associate Professor Peter Hickman, Director of
Clinical Chemistry Pathology; ANU Medical
School
Professor Ted Maddess, Australian National
University
Professor Stefan Broer, Australian National
University
Associate Professor Anand Hardikar, University of
Sydney
Professor Marc Prentki, University of Montreal
Associate Professor Charmaine Simeonovic,
Professor Alicia Jenkins, University of Sydney
Graduations
Mrs Erandi Hewawasam, Science Honours,
Dr Tony Huynh, PhD, Australian National University
Dr Tehzeeb Zulfiqar, Masters of Public Health,
Research projects
Project title: Placental Responses to Obesity and
Pregnancy Outcomes (PROPOS)
Fund Major Research Grant
Project title: Role of Islet β-cell Failure in the
Pathogenesis of Non-Alcoholic Steatohepatitis
Project title: Novel Functional Testing for Early
Diabetic Retinopathy
Principal investigator: T Maddess
Project title: The Role of Iron in Inflammatory Set
Injury
Principal investigator: V Delghingaro-Augusto
(DART)
53
Project title: The Role of Maternal Iron in Offspring
Pancreatic Islet Injury and Inflammation
Principal investigator: V Delghingaro-Augusto
Funding source: Australasian Diabetes in Pregnancy
Society – Novo Nordisk
Project title: The Role of the Glucocorticoid
Receptor in Duchenne Muscular Dystrophy
Principal investigator: T Huynh
Project title: Trimester Specific TFTs after
Characterisation of Iodine and Autoimmune Status
of the Canberra Population
Principal investigator: S Perampalam
Project title: Validation of SLC6A19 as a Target to
Improve Type 2 Diabetes
Principal investigator: S Broer
Funding source: Sanofi Aventis
Project title: Patient Self-Titration Insulin Model of
Care
Principal investigator: L Bancroft
Funding source: ACT Health Nursing and Midwifery
Research
Project title: ADVANCE-ON: Action in Diabetes
and Vascular Disease: Preterax and Diamicron MR
Controlled Evalulation Post-Trial Observational
Study
Funding source: Servier Laboratories
Project title: CANVAS-R Study
Funding source: Janssen
Awards
CHARM 2014 – Radiation Oncology Private
Practice Trust Fund Award for the Best
Laboratory Research Oral Presentation
Ms Tenzin Dagpo
Diabetes Australia Award for best funded
research project application in the ACT 2013
(presented by Hon Judy Moylan (Chair of DA Board,
28/06/2014)
Dr Viviane Delghingaro-Augusto
54
Geriatric Medicine, Rehabilitation Aged
and Community Care
The Department of Geriatric Medicine,
Rehabilitation Aged and Community Care (RACC),
Canberra Hospital and Health Services (CHHS)
continued to undertake research activities in the
area of Geriatric Medicine and Orthogeriatrics.
For the years 2013 and 2014, the research
activities were disseminated in multiple formats
including publications in peer reviewed journals and
presentations at national and international conferences.
Staff
Dr Anil Paramadhathil, Director and Senior Staff
Specialist, RACC, CHHS
Associate Professor Alexander Fisher, Senior Staff
Specialist, RACC, CHHS
Associate Professor Michael Davis, Director and
Senior Staff Specialist, RACC, CHHS
Dr Ruth Teh, Advanced Trainee Registrar
Dr Elizabeth Liow, Junior Medical Officer
Dr M Choudhary, Advanced Trainee Registrar
Dr H Haque, Advanced Trainee Registrar
Students
Ms Holly Powell, MBBS, Australian National University
Supervisor: Dr Alexander Fisher
Mr Yiu Ting Wai, MBBS, Australian National University
Mr Wasif Mirza, MBBS, Australian National University
55
Haematology
The Department of
Haematology provides a
large diagnostic laboratory
and transfusion service to
the ACT and south east
NSW. Department members
are also involved in clinical
work diagnosing and treating
the complete range of
haematological cancers, clotting
and bleeding disorders and
clinical transfusion medicine.
The department runs a tissue
bank, the ACT Haematology
Research Tissue Bank, which
facilitates translational
research in haematological and
related disorders.
The Haematology Research unit
conducts, coordinates and manages a diverse range
of quality clinical trials and data registries through
the Clinical Haematology Department – Canberra
Region Cancer Centre (CRCC), Canberra Hospital.
The unit also manages a Haematology Translational
Research Unit through which the Haematology
Research Tissue Bank is managed in the Laboratory
Haematology Department – ACT Pathology. The
majority of the consultants have joint appointments
with the ANU Medical School.
The unit currently has 34 active clinical trials
that provide access to emerging therapies and
maintain clinical practice in an environment of
evidence-based medicine. The portfolio of clinical
trials includes both malignant and non-malignant
haematological conditions and varies from Phase I
to Phase IV Studies.
The unit currently consists of eight Haematologists
and seven Advanced Trainees, acting as either
Principal or Sub-Investigators and four Clinical Trials
Coordinators who have a mix of clinical research
and nursing experience.
Patients are enrolled in the Canberra district
and across southern NSW as a central referral
site for many haematology studies. Over recent
years, hundreds of patients have par ticipated
in and benefited from access to emerging
medications through clinical research in the
Haematology Depar tment.
The unit has a combination of both investigatorinitiated collaborative group studies and industry
sponsored trials. The unit’s financial independence
is underpinned by the national support of
collaborations with the Australasian Leukaemia and
Lymphoma Group (ALLG) and income derived
from pharmaceutical sponsored studies.
In addition to clinical trials, the department has a
growing basic and translational research program
with defined links with the John Curtin School of
Medical Research, Australian National University.
Several ANU Medical School and research students
are supervised by our staff.
This includes investigator-led translational
research in the areas of lymphoma biology, cellular
metabolism in myeloma, pathophysiology of
immune cytopenias and the phenotype of flippase
11c mutations. Some of these projects are in
collaboration with national collaborators.
56
Staff
Dr James D’Rozario, Director, Department of
Haematology
Dr Philip Crispin, Haematologist
Dr Maya Latimer, Haematologist
Dr Edwin Lee, Haematologist
Dr Emma Palfreyman, Haematologist
Dr Nalini Pati, Haematologist
Dr Michael Pidcock, Haematologist
Associate Professor Dipti Talaulikar, Haematologist;
Head, Haematology Translational Research
laboratory, and ACT Haematology Research
Tissue Bank
Dr Israfil Baluwala, Advanced Trainee
Dr Samuel Bennett, Advanced Trainee
Dr Renee Eslick, Advanced Trainee
Dr Amy Jean Holmes, Advanced Trainee
Dr Maansi Joshi, Advanced Trainee
Dr Yadanar Lwin, Advanced Trainee
Dr David Rabbolini, Advanced Trainee
Dr Lucy Coupland, Research Fellow JCSMR
Dr Anneke Blackburn, Research Fellow
Ms Katherine Johnson, Clinical Trials Manager
Ms Heidi West, Finance Support Officer
Ms Julie Asquith, Clinical Trials Coordinator
Ms Laura Billing, Clinical Trials Coordinator
Ms Caitlin Lawler, Clinical Trials Coordinator
Ms Chris Twyford, Clinical Trials Manager
Ms Leah Peut, Clinical Trials Coordinator
Ms Tracey Hay, Clinical Trials Manager
Ms Anais le Gall, Clinical Trials Manager
Mr Donovan Martin, Clinical Trials Coordinator
Ms Yvonne Gonzales, Haematology Research Tissue
Bank Officer
Dr Andrew Ziolkowski, Haematology Translational
Research Unit
Students
Dr Dan Dan Tian, PhD, Australian National
University
Supervisors: Dr Anneke Blackburn, Dr Lucy
Coupland, Dr James D’Rozario
Mr Joshua Tobin, M Phil, Australian National
University
Supervisors: Associate Professor Dipti Talaulikar,
Professor Chris Goodnow
Ms Nana Yaa G Owusu-Tieku, Master Advanced
Project in Biology BIOL8701, Australian National
University
Supervisors: Associate Professor Dipti Talaulikar,
Dr Andrew Ziolkowski, Professor Chris Goodnow
Ms Suet-Voon Yu, PhD, Australian National University
Supervisors: Dr Gerlese Akerlind, Ms Pam Roberts,
Associate Professor Dipti Talaulikar
Mr Patrice Albert-Thenet, MBBS, Australian National
University
Supervisor: Associate Professor Dipti Talaulikar
Ms Rowena Penafiel, MBBS, Australian National
University
Ms Sophia Ang, MBBS, Australian National University
Supervisors: Professor Matthew Cook, Associate
Professor Dipti Talaulikar
Ms Madeleine Neill, BSc (Hons), Australian National
University
Mr Rhys Williams, BSc (Hons), Australian National
University
Collaborators
Dr Anneke Blackburn, JCSMR, Australian National
University
Dr Dan Tiang, JCSMR, Australian National University
Professor Matthew Cook, JCSMR, Australian
National University
Professor Chris Goodnow, JCSMR, Australian
National University
Professor Maher Gandhi, University of Queensland
Dr Lucy Coupland, JCSMR, Australian National
University
Professor Chris Parish, JCSMR, Australian National
University
Dr Anselm Enders, JCSMR, Australian National
University
Dr Mehmet Yabas, JCSMR, Australian National
University
Graduations
Ms Nana Yaa G Owusu-Tieku, Masters Advanced
Project in Biology, Australian National University
Visitors
Dr Pranav Dorwal, Visiting Fellow, Haematology
Translational Research Unit, Medanta Hospital,
India
57
Research projects
CURRENT PROJECTS
Project title: APL-C-001-09 (ADMYRE) – A
Randomized, Multicentre, Open-Label, Phase
III Study of Plitidepsin in Combination with
Dexamethasone vs Dexamethasone Alone in
Patients with Relapsed/Refractory Multiple Myeloma
Principal investigator: J D’Rozario
Funding source: Pharma Mar S.A / Pharma Mar
USA Inc.
Project title: AC220-007 (AMBIT) – A Phase 3
Open-Label Randomized Study of Quizartinib
(AC220) Monotherapy Versus Salvage Chemotherapy
in Subjects with FLT3-ITD Positive Acute Myeloid
Leukemia (AML) Refractory to or Relapsed After
First-Line Treatment with or Without Hematopoietic
Stem Cell Transplantation (HSCT) Consolidation
Funding source: Ambit Biosciences Corporation
Project title: BAYER 16349 – An Open-label,
Uncontrolled Phase II Trial of Intravenous PI3K
Inhibitor BAY 80-6946 in Patients with Relapsed,
Indolent or Aggressive Non-Hodgkin Lymphomas
Principal investigator: P Crispin
Funding source: Bayer Australia Ltd
Project title: BDM3502 (ROBIN) – A Randomised,
Open Label, Multi-Centre Phase III Study to
Investigate the Efficacy of Bendamustine Compared
to Treatment of Physician’s Choice in the
Treatment of Subjects with Indolent Non-Hodgkin
Lymphoma (NHL) Refractory to Rituximab
Principal investigator: M Latimer
Funding source: Mundipharma Research Ltd /
Mundipharma Pty Ltd
Project title: BI 1301.5 – A Randomized, DoubleBlind, Parallel-Arm, Phase I Study to Evaluate
Pharmacokinetics and Pharmacodynamics of BI
695500 vs Rituximab (Mabthera®) Induction
Immunotherapy as First Line Treatment in Patients
with Low Tumor Burden Follicular Lymphoma
Funding source: Boehringer Ingelheim International
GmbH
Project title: Bright 3064 – An OpenLabel, Randomized, Parallel-Group Study of
Bendamustine Hydrochloride and Rituximab (BR)
Compared with Rituximab, Cyclophosphamide,
Vincristine, and Prednisone (R-CVP) or
Rituximab, Cyclophosphamide, Doxorubicin,
Vincristine, and Prednisone (R-CHOP) in the
First-Line Treatment of Patients with Advanced
Indolent Non-Hodgkin Lymphoma (NHL) or
Mantle Cell Lymphoma (MCL)
Funding source:Teva Branded Pharmaceuticals R&D Inc.
Project title: Eloquent 1 – A Phase 3, Randomized,
Open Label Trial of Lenalidomide/Dexamethasone
with or without Elotuzumab in Subjects with
Previously Untreated Multiple Myeloma
Funding source: Bristol Myers Squibb International
Corporation
Project title: Eloquent 2 – A Phase 3, Randomized
Open Label Trial of Lenalidomide /Dexamethasone
With or Without Elotuzumab in Relapsed or
Refractory Multiple Myeloma
Corporation
Project title: ENESTswift – A Multicenter, Single
Arm Study to Assess Efficacy and Safety of
Nilotinib 300mg BD in Patients with Philadelphia
Positive Chronic Myeloid Leukemia in Chronic
Phase (Ph+ CML-CP) who are Intolerant to Prior
Tyrosine Kinase Inhibitors (Tkis)
Funding source: Novartis Pharmaceuticals Australia
Pty Ltd
Project title: ENESTxtnd – Extending Molecular
Responses with Nilotinib in Newly Diagnosed
Chronic Myeloid Leukemia (CML) Patients in
Chronic Phase
Principal investigator J D’Rozario
Funding source: Novartis Pharmaceuticals Australia
Pty Ltd
Project titlee: GO28667 (Murano) – A Multicenter,
Phase III, Open-Label, Randomized Study in
Relapsed/Refractory Patients with Chronic
Lymphocytic Leukemia to Evaluate the Benefit of
GDC-0199 (ABT-199) Plus Rituximab Compared
with Bendamustine Plus Rituximab
Funding source: F. Hoffmann-La Roche Ltd / AbbVie
Inc
Project title: ITP Registry – A Multi-Centre,
Prospective Disease Registry for Adults Diagnosed
with Primary Immune Thrombocytopenia (ITP) in
International Countries
Funding source: GlaxoSmithKline Australia Pty Ltd
Project title: 13X-MC-JHTB – A Multicenter,
Nonrandomized, Open-Label, Single-Arm
Phase 2 Study of LY2784544 in Patients with
Myeloproliferative Neoplasms
Funding source: Eli Lilly and Company
58
Project title: PCYC-1127-CA (iNNOVATE)
– A Randomized, Double-Blind, PlaceboControlled, Phase 3 Study of Ibrutinib or
Placebo in Combination with Rituximab in
Subjects with Previously Treated Waldenstrom’s
Macroglobulinemia
Principal investigator: D Talaulikar
Funding source: Pharmacyclics Inc.
Project title: PNH Registry – Paroxysmal Nocturnal
Haemoglobinuria (PNH) Registry is a Prospective
Multi-Centre, Multi-National, Observational NonInterventional Study with Enrolment of PNH Patients
Treated with Soliris, and PNH Patients not Receiving
Soliris Therapy. The PNH Registry will Capture
Post Marketing Pharmacovigilance Data on Patients
Treated with Soliris and will Collect Information on
the Progression of Disease for these Patient Groups.
Funding source: Alexion Pharmaceuticals Inc.
Project title: PrefMab MO28457 – A Randomised,
Open-Label, Multi-Centre Study to Evaluate Patient
Preference with Subcutaneous Administration
of Rituximab Versus Intravenous Rituximab in
Previously Untreated Patients with CD20+ Diffuse
Large B-Cell Lymphoma or CD20+ Follicular
Non‑Hodgkin Lymphoma Grades 1, 2 or 3a
Funding source: F. Hoffmann-La Roche Ltd
Project title: VALOR – A Phase III, Randomised,
Controlled, Double-Blind, Multinational Clinical
Study of the Efficacy and Safety of Vosaroxin and
Cytarabine Versus Placebo and Cytarabine in
Patients with First Relapsed or Refractory Acute
Myeloid Leukaemia
Funding source: Sunesis Pharmaceuticals Inc.
Project title: ALLG ALL6 – A Phase II Trial of an
Intensive Paediatric Protocol Incorporating Post
Induction Stratification based on Minimal Residual
Disease Levels for the Treatment of Adolescents
Aged 15 Years and Above, and Young Adults
Aged up to 40 Years with Newly Diagnosed Acute
Lymphoblastic Leukaemia (ALL)
Funding source: ALLG
Project title: ALLG AML M12 – A PlaceboControlled, Randomised Trial of the Effect of
Palifermin on Severe Oral Mucositis Following
Intensive Induction Chemotherapy Incorporating
High Dose Cytarabine and a Randomised Trial
of Idarubicin Dose Escalation in Consolidation
Therapy in Patients with Untreated Adult Acute
Myeloid Leukaemia
Project title: ALLG AML M13 – High Dose
Cytarabine and Fludarabine Without Anthracycline
for Patients with Core Binding Factor Acute
Myeloid Leukemia
Project title: ALLG AML M16 – Sorafenib in
Combination with Intensive Chemotherapy for
Previously Untreated Adult FLT3-ITD Positive
AML: A Phase II Randomised Double-Blind Placebo
Controlled Multi-Centre Study
Project title: ALLG AML M18 Registry –
Australasian Leukaemia and Lymphoma Group
Acute Myeloid Leukaemia Registry
Project title: ALLG CLL6 – An Australasian, Phase
III, Multicentre, Randomised Trial Comparing
Lenalidomide Consolidation vs No Consolidation
in Patients with Chronic Lymphocytic Leukemia
and Residual Disease Following Induction
Chemotherapy
Project title: ALLG CML9 (Tidel II) – A Phase II
Study in Adult Patients with Newly Diagnosed
Chronic-Phase Chronic Myeloid Leukaemia of Initial
Intensified Therapy and Sequential Dose-Escalation
Followed by Treatment with Nilotinib in Suboptimal
Responders to Determine the Rate and Duration
of Major Molecular Response
Project title: ALLG HD8 (Rathl) – A Randomised
Phase III Trial to Assess Response Adapted Therapy
Using FDG-PET Imaging in Patients with Newly
Diagnosed, Advanced Hodgkin Lymphoma
Project title: ALLG MDS4 – A Randomised Phase
II Study Comparing the Efficacy of 5-Azacitidine
Alone Versus Combination Therapy with
Lenalidomide and 5-Azacitidine in Patients with
Higher Risk Myelodysplastic Syndromes (MDS)
and Low Marrow Blast Count Acute Myeloid
Leukaemia (AML)
Project title: ALLG MM14 – A Prospective
Randomised Phase II Study of Single Agent
Pomalidomide Maintenance Versus Combination
59
Pomalidomide and Low Dose Dexamethasone
Maintenance Following Induction with the
Combination of Pomalidomide and Low Dose
Dexamethasone in Patients with Relapsed and
Refractory Myeloma Previously Treated with
Lenalidomide
Project title: ALLG MM15 – A Randomised
Phase III Study to Compare Bortezomib,
Melphalan, Prednisone (VMP) with High Dose
Melphalan followed by Bortezomib, Lenalidomide,
Dexamethasone (VRD) Consolidation and
Lenalidomide Maintenance in Patients with Newly
Diagnosed Multiple Myeloma
Project title: ALLG MPN01 – Myeloproliferative
Neoplasms Registry
Project title: ALLG NHL14 (Watch & Wait) –
An Intergroup Randomised Trial of Rituximab
Versus a Watch and Wait Strategy in Patients
with Advanced Stage, Asymptomatic Non-Bulky
Follicular Lymphoma (Grades 1, 2, 3a)
Project title: ALLG NHL16 (Prima) – A Multicentre
Phase III Open-Label Randomized Study in Patients
with Advanced Follicular Lymphoma Evaluating the
Benefit of Maintenance Therapy with Rituximab
After Induction of Response with Chemotherapy
Plus Rituximab in Comparison with no Maintenance
Therapy
Project title: ALLG NHL25 (Remarc) – Double
Blind Randomised Phase III Study of Lenalidomide
Maintenance versus Placebo in Responding Elderly
Patients with DLBCL and Treated with R-CHOP in
First Line
Project title: ALLG Tissue Banking – Establishment
of the AMP Leukaemia and Lymphoma Tissue Bank
Funding source: ALLG / The Leukaemia Foundation
Project title: NHLLOW5 – A Randomised,
Multicentre Trial of Involved Field Radiotherapy vs
Involved Field Radiotherapy Plus Chemotherapy for
Stage I-II Low Grade Follicular Lymphoma
Funding source: The Trans-Tasman Radiation
Oncology Group Ltd (TROG)
PROJECTS COMPLETED IN 2013–2014
Project title: AMPLIFY C185056 – A Safety and
Efficacy Trial Evaluating the use of Apixaban for the
Extended Treatment of Deep Vein Thrombosis and
Pulmonary Embolism
Corporation
Project title: AMPLIFY C185057 (Ext) – A Safety
and Efficacy Trial Evaluating the use of Apixaban for
the Extended Treatment of Deep Vein Thrombosis
and Pulmonary Embolism
Corporation
Project title: ASPIRE – A Multicentre, Randomised,
Double-Blind, Placebo-Controlled Clinical Trial
Examining the Efficacy and Safety of Low-Dose
Aspirin After Initial Oral Anticoagulation to Prevent
Recurrent Venous Thromboembolism
Funding source: Agios Pharmaceuticals Inc.
Project title: Bright 3070 – Study to Assess
the Effect of Treatment with Bendamustine in
Combination with Rituximab on QT Interval in
Patients with Advanced Indolent Non-Hodgkin
Lymphoma (NHL) or Mantle Cell Lymphoma (MCL)
Funding source: Teva Branded Pharmaceuticals
R&D Inc.
Project title: E5501-G000-302 – A Phase III,
Multicentre, Randomized, Double-Blind, PlaceboControlled, Parallel-Group Trial with an OpenLabel Extension Phase to Evaluate the Efficacy and
Safety of Oral E5501 Plus Standard of Care for the
Treatment of Thrombocytopenia in Adults with
Chronic Immune Thrombocytopenia
Funding source: Eisai Inc.
Project title: EPIC – A Phase III Randomised,
Open-Label Study of Ponatinib Versus Imatinib
in Adult Patients with Newly Diagnosed Chronic
Myeloid Leukaemia in Chronic Phase
Funding source: Ariad Pharmaceuticals Inc.
60
Project title: EXTEND – An Extension Study of
Eltrombopag Olamine (SB-497115-GR) in Adults
with Idiopathic Thrombocytopenic Purpure (ITP),
Previously Enrolled in an Eltrombopag Study
Principal investigator: M Pidcock
Funding source: GlaxoSmithKline Australia Pty Ltd
Project title: HOKUSAI (DU176b-D-U305) –
A Phase III, Randomised, Double-Blind, DoubleDummy, Parellel-Group, Multicentre, Multinational
Study for the Evaluation of Efficacy and Safety
of (LMW) Heparin/Edoxaban Versus (LMW)
Heparin/Warfarin in Subjects with Symptomatic
Deep-Vein Thrombosis and/or Pulmonary
Embolism
Funding source: Daiichi Sankyo Inc.
Project title: JCBJ (Prelude) – A Phase III Study to
Investigate the Prevention of Relapse in Lymphoma
using Daily Enzastaurin
Principal investigator: Dr James D’Rozario
Funding source: Eli Lilly and Company
Project title: PIMMS – A Phase II Trial of PAD
Induction Therapy in Transplant-Eligible Patients
with Untreated Multiple Myeloma (MM), Stratified
for Markers of Bortezomib Resistance
Project title: Romiplostim (AMG 531) –
A Prospective, Phase IV, Open-Label, MultiCenter Study Evaluating Changes in Bone
Marrow Morphology in Adult Subjects
Receiving Romiplostim for the Treatment of
Thrombocytopaenia associated with Immune
(Idiopathic) Thrombocytopaenia Purpura (ITP)
Funding source: Amgen Inc.
Project title: TITAN (ALX-0681-2.1/10) – A Phase
II Single-Blind, Randomised, Placebo-Controlled
Trial to Study the Efficacy and Safety of Anti-Von
Willebrand Factor Nanobody Administered as
Adjunctive Treatment to Patients with Acquired
Thrombotic Thrombocytopenic Purpura (TTP)
Funding source: Ablynx NV
Project title: ALLG AML M14 – A Program for
Development for Older Patients with Acute
Myeloid Leukaemia and High Risk Myelodysplastic
Syndrome
Project title: ALLG BOMeR – An Australian
Multicentre, Phase II Study of Bortezomib
(VELCADE) and Dexamethasone as Treatment
and Maintenance for Patients with Multiple
Myeloma who have Relapsed after Autologous
BMT or Following Re-Induction with Thalidomide
and/or Dexamethasone
Project title: ALLG CLL5 – An Australasian, Phase
II, Multicentre, Randomised, Dose Intensification
Study Investigating Oral Fludarabine, Oral
Cyclophosphamide and I.V Rituximab (Pofcivr)
Tolerance in Previously Untreated Elderly (> 65
Years Old) Patients with Chronic Lymphocytic
Leukaemia (CLL)
Project title: ALLG LYO 3 (WMI) – A Randomised
Trial of Chlorambucil versus Fludarabine as Initial
Therapy of Waldenstrom’s Macroglobulinaemia and
Splenic Lymphoma with Villous Lymphocytes
Principal investigator: I Prosser
Funding source: ALLG and Central and Southern
Lymphoma Group (UK)
61
Project title: ALLG MDS3 – A Phase I/II Trial to
Determine Safety and Efficacy of Combination
Therapy with 5-Azacitidine (Vidaza) and
Thalidomide in Patients with Myelodysplastic
Syndromes (MDS)
Project title: R-IE - Outpatient Ifosfamide,
Etoposide plus Rituximab (R-IE) for Salvage in
Patients > 60 Years with Relapsed or Refractory
CD 20 Positive Diffuse Large B-Cell Lymphoma
who are not Candidates for Stem Cell Transplant
Funding source: St Vincents Hospital, Melbourne,
Westmead Hospital, Westmead
Awards
Tony Ayres Ward, John James Foundation
Dr Anneke Blackburn
ANU Medical School Dean’s award for teaching
innovation
Associate Professor Dipti Talulikar
Canberra Region Annual Scientific Meeting best
poster prize for laboratory research
Associate Professor Dipti Talaulikar
Grants
Recipient: D Talaulikar
Fund
Project title: Cellular origin of Non-Hodgkin
Lymphoma
Recipient: S Bennett
Fund
Project title: Dichloroacetate in Myeloma
Recipient: D Talaulikar
Funding source: Royal College of Pathologists of
Australasia
Project title: Virtual Microscopy Library
Recipient: A Blackburn
Funding source: ACT Cancer Council
Recipients: A Blackburn, S Bennett, P Crispin,
J D’Rozario
Fund
Recipients: L Coupland, C Parish, P Crispin,
J D’Rozario
Fund
Project title: Immuno-Pathophysiology in a Mouse
Model of Immune Thrombocytopenia
62
Immunology
The Immunology Department is a referral
service for adults and children with any form
of immune-mediated disease. We manage
patients with systemic autoimmunity, systemic
inflammatory diseases, primary immune
deficiency and hypersensitivity disorders, including
allergy. In addition to this clinical load, we have
a strong record of academic achievement and
a very active research program. Together with
the Translational Research Unit (see separate
entry), members of the Immunology Department
have attracted continuous NHMRC funding
for more than ten years. Our research effort
focuses on understanding the genetic and
cellular basis of autoimmunity and immune
deficiency. We run two major Australian studies
of immune diseases: lupus (Australian Point
Mutation in SLE, APOSLE) and primary immune
deficiency (Australian and New Zealand
Antibody Deficiency Study, ANZADA). We
conduct specific projects investigating the cellular
mechanisms of other immune deficiency diseases,
including hyper IgE syndrome and DOCK8related immune deficiency. We conduct research
into understanding the genetic and cellular basis
of sarcoidosis, vasculitis, and other forms of
autoimmune disease. We participate in a number
of clinical trials for new therapies, particularly
investigating biological therapies for lupus and
systemic vasculitis.
Professor Cook is Co-Director of the NHMRC
Centre for Research Excellence in Personalised
Immunology (http://jcsmr.anu.edu.au/research/cpi).
Staff
Professor Matthew Cook, Director of
Immunology
Professor Paul Gatenby AM, Staff Specialist;
Emeritus Professor of Immunology, Australian
National University
Dr Carolyn Hawkins, Staff Specialist; Lecturer,
Dr Katrina Randall, Staff Specialist; Senior Lecturer,
Dr Elizabeth DaSilva, Research Fellow
Dr Gary Chew, Clinical Fellow
Ms Anastasia Wilson, Research Nurse
Students
Ms Lisa Hsu, MBBS, Australian National University
Supervisor: Professor Matthew Cook
Ms Dennise-Angela Castaneda, MBBS, Australian
National University
Mr Jeremy Chou, MBBS, Australian National
University
Ms Catherine Jun, MBBS, Australian National
University
Collaborators
Professor Krisztina Valter-Kosci, Professor Jan Provis,
Associate Professor Michelle Madigan, Jane
Oliaro; Peter MacCallum Cancer Centre
Research projects
Project title: Cell Subsets in DOCK8 Deficient
Mice
Principal investigator: K Randall
Project title: Characterising Immune Deficiency in
Sarcoid Patients
Principal investigator: P Gatenby, DA Castaneda
Project title: Clinical Outcome of Patients
with Dual Positivity for Proteinase 3 and
Myeloperoxidase Specific Antineutrophil
Cytoplasmic Antibodies
Principal investigator: P Gatenby, J Chou
63
Clinical trials
Project title: A Phase III Randomized Double-Blind,
Placebo-Controlled Multicenter Study of Icatibant
for Subcutaneous Injection in Patients with Acute
Attacks of Hereditary Angioedema (HAE)
Project title: A Randomized, Double-Blind,
Placebo-Controlled 52-Week Study to Assess
Adverse Events of Special Interest In Adults With
Active, Autoantibody-Positive Systemic Lupus
Erythematosus Receiving Belimumab
Project title: Phase IIa, 2:2:1 Randomised, DoubleBlind, Placebo-Controlled, Parallel Group, MultiCentre Clinical Trial to Investigate the Safety,
Efficacy and Pharmacokinetics of Recombinant
Human Soluble Fc-Gamma Receptor Iib (SM101)
for Intravenous Application in the Treatment of
Systemic Lupus Erythematosus (SLE) Patients with
or without a History of Lupus Nephritis
Project title: A Phase 3, Multi-center,
Multinational, Randomized, Double-Blind, Study
to Evaluate the Efficacy and Safety of Belimumab
(HGS1006) in Combination with Azathioprine
for the Maintenance of Remission in Wegener’s
Granulomatosis and Microscopic Polyangiitis
Project title: Australian Xolair Register for Severe
Asthma
Project title: Efficacy and Side-Effects of
Maintenance Therapy in ANCA-Associated
Vasculitis
Project title: NDORMS DCVAS – Data Driven
Development of New Classification and Diagnostic
Criteria for Primary Systemic Vasculitis
Sponsor: Oxford University
Awards
Poster prize, ASCIA, 2014
Mr Jeremy Chou
Best Poster Prize, EAACI Copenhagen 2014
Dr Katrina Randall
Grants
Recipients: C Goodnow, C Mackay, J Sprent,
C Vinuesa, F Mackay, R Brink, S Tangye, M Cook
Funding source: NHMRC (2012–2016)
Project title: Molecular and Cellular Basis of
Inflammatory and Immunodeficiency Diseases
Grant amount: $15,718,075
Recipients: C Vinuesa, M Cook, D Fulcher,
S Alexander, A Kitching, A Enders, R Casellas, M Field,
K Schwarz, T Andrews
Funding source: NHMRC Centre for Research
Excellence 2014–2018, Centre for Personalised
Immunology
Recipients: M Cook, D Tscharke, D Fulcher
Project title: Genomic Medicine for Human
Immune Deficiency
Recipients: K Valter-Kosci, J Provis, P Gatenby,
M Madigan
Project title: Fighting Age-Related Macular
Degeneration by Reducing Inflammatory Events
Recipient: K Randall
Project title: Investigation of Cellular
Abnormalities and Synapse Formation in DOCK8
Immunodeficiency
Recipient: M Cook
Funding source: Perpetual Fund 2013
Project title: Flow Cytometry for Diagnosis of
Primary Immune Deficiency
Recipients: J D’Rozario, P Crispin, L Coupland,
M Cook, C Parish
Fund Major Project Grant 2013
Project title: Auto-Immune Cytopenias: Mechanisms,
Novel Treatment Avenues and DNA Analysis
Recipients: D Taupin, M Cook
Fund Small Project Grant 2014
Project title: Whole Exome Sequencing and
Phenotyping in Families with Serrated Polyposis
64
Infectious Diseases, Microbiology and
Infection Prevention and Control
Infectious Diseases, Microbiology and
Infection Prevention and Control have
extensive interests and outreach in
Australia and internationally. We are
working with a large number of people
around the world to decrease the
spread of antibiotic resistant bacteria
and decrease the number of healthcare
associated infections.
Staff
Professor Peter Collignon AM, Senior
Specialist; Professor, ANU Medical
School; Infectious Diseases Physician
and Microbiologist
INFECTION PREVENTION AND CONTROL
Ms Wendy Beckingham
Ms Jan Roberts
Ms Kimberley Phelan
Ms Fiona Kimber
Ms Andrea Menzies
Ms Heather Warfield
Ms Teena Russell
Ms Sammi Xu
MICROBIOLOGY
Dr Carolyn Hawkins, Senior Specialist, Immunology
Dr Anindita Das, Microbiology Registrar
Ms Susan Bradbury, Chief Scientist Microbiology
Ms Cherie O’Brien, Scientist Microbiology
Students
Ms Emily Briggs, MBBS, Australian National
University
Supervisor: Dr Karina Kennedy
Ms Sarina Gloeckl, MBBS, Australian National
University
Supervisor: Dr Kathryn Daveson
Ms Hilda Lam, MBBS, Australian National University
Mr Kevin Zhou, MBBS, Australian National University
Ms Sara Hamdani, MBBS, Australian National University
Supervisor: Professor Julia Potter
Mr Longhai Jin, MBBS, Australian National University
Mr Andrew MacPherson, MBBS, Australian National
University
Supervisor: Ms Wendy Beckingham RN
Ms Stella Son, MBBS, Australian National University
Supervisor: Dr Melinda Ford
Ms Sarah Bachman, MBBS, Australian National
University
Supervisor: Dr Ashley Watson
Ms Caren Laubscher, MBBS, Australian National
University
Supervisors: Dr Peter Barry, Professor David
Hardman
Mr Philip Gaughwin, MBBS, Australian National
University
Supervisor: Professor Peter Collingon
Grants
Recipients: R Lucas, R Neale, P Hart, P Gies,
N Pandeya, J Sherriff, A Swaminathan
Funding source: Cancer Australia
Project title: Sun Exposure and Vitamin D
Supplementation Study
65
Inflammatory Bowel Disease Research
The Inflammatory Bowel Disease (IBD)
research group has a number of active
research projects, aimed at better
understanding the IBDs, and is currently
conducting clinical trials for new therapies.
Over the past years, the laboratory has
been using high-throughput sequencing
to describe the microbial communities
of early- and late-stage Crohn’s disease
tissues, and has just embarked on a
project looking simultaneously at the
host transcriptome and microbiome. We
have also been investigating the role of
adherent, invasive Escherichia coli as it is
a leading candidate bacterial trigger for
Crohn’s disease. Our IBD Service has been involved
in many international multicentre drug trials, and
we continue to build our biobank of materials for
research purposes.
Staff
Professor Paul Pavli, Senior Specialist
Dr Claire O’Brien, Principal Research Officer
Dr Arun Gupta, Staff Specialist
Dr Kavitha Subramaniam, Staff Specialist
Dr Christopher Kiely, Registrar
Dr Graham Kaye, Acting head of the
Gastroenterology and Hepatology Unit;
Endoscopy
Dr Andrew Thomson, Endoscopy, Registered
Medical Officer
Dr Vipul Aggarwal, Endoscopy, Staff Specialist
Students
Ms Stephen Bomball, MChD, ANU Medical School
Supervisors: Professor Paul Pavli, Dr Claire O’Brien
Ms Amie McCosker, MChD, ANU Medical School
Ms Angelina (Wenchi) Che, MChD, ANU Medical
School
Mr Andy Leu, BSc (Honours), ANU Medical School
Supervisors: Professor Paul Pavli, Dr Claire O’Brien,
Dr Gwen Allison
Collaborators
Professor David Gordon, Australian National
University
Dr Marie Agnès-Bringer, University of Auvergne,
Clermont-Ferrand, France
Professor Arlette Darfeuille-Michaud, University of
Auvergne, Clermont-Ferrand, France
Dr Kathryn Holt, University of Melbourne
Dr Gwen Allison, Australian National University
Graduations
Dr Arun Gupta, Doctor of Medicine, University of
Melbourne
Mr Andy Leu, BSc (Honours I), Australian National
University
Research projects
Project title: Host-Microbe Interactions in Crohn’s
Disease
Principal investigator: C O’Brien
Project title: Comparative Genome Analysis of
the Crohn’s Disease-Associated Adherent, Invasive
Escherichia coli
Principal investigators: C O’Brien, P Pavli
Funding source: Australian Academy of Science;
Gastroenterological Society of Australia
Project title: Metabolically active Bacteria in Lymph
Nodes and Mucosa of Crohn’s Disease Patients
Principal investigators: C Kiely, C O’Brien, P Pavli
66
Project title: Diversity of Escherichia coli along the
Intestinal Tract in Health and Inflammatory Bowel
Disease
Principal investigators: D Gordon, C Kiely,
C O’Brien, P Pavli
Project title: The Microbiome of Early- and
Late‑Stage Tissues from Crohn’s Disease Patients
Project title: In silico Analysis of the Distribution
and Frequency of Bacteriocins in Escherichia coli
Isolated from Crohn’s Disease Tissues
Project title: Antibiotic Resistance in Escherichia coli
Isolated from Crohn’s Disease Patients
Project title: Mycobacterium avium Subspecies
Paratuberculosis – Specific PCR Screening of Crohn’s
Disease Mucosa and Lymph Nodes
Project title: Relative Abundance of Mycobacterium
avium Subspecies Paratuberculosis in Johne’s Disease
Project title: Anti-TNF Therapy in Pregnant
Patients with Inflammatory Bowel Disease
Principal investigators: C Kiely, K Subramaniam,
P Pavli
Project title: A Multicentre, Randomised,
Double‑Blind, Placebo-Controlled, Parallel-Group
Study of Oral CP-690,550 as an Induction Therapy
in Subjects with Moderate to Severe Ulcerative
Colitis ‘The OCTAVE Study’ A3921095 ACT
Principal investigator: A Gupta
Funding source: Pfizer
Project title: A Multicentre, Randomised, DoubleBlind, Placebo-Controlled, Parallel-Group Study
of Oral CP-690,550 as a Maintenance Therapy
in Subjects with Moderate to Severe Ulcerative
Colitis ‘The OCTAVE Study’ A3921096 ACT
Project title: A Multicentre, Open Label Study of
Oral CP-690,550 in Subjects with Moderate to
Severe Ulcerative Colitis ‘The OCTAVE Study’
A3921139 ACT
Project title: Predicting Serious Drug Side Effects
in Gastroenterology (PRED4) – Thiopurine
Induced Liver Injury in Inflammatory Bowel Disease
– Multicentre Study to Investigate the Genetic
Contribution to Serious Adverse Drug Reactions
Principal investigator: K Subramaniam
Project title: Predicting Serious Drug Side Effects in
Gastroenterology (PRED4) – Thiopurine Induced
Myelosuppression in Inflammatory Bowel Disease
Project title: Predicting Serious Drug Side Effects
in Gastroenterology (PRED4) – Demyelination
Complicating Anti-TNF Therapy in Inflammatory
Bowel Disease and Other Inflammatory Disorders
Awards
Australian Academy of Science France-Australia
Science Innovation Collaboration Early Career
fellowship
Dr Claire O’Brien
Grants
Recipient: C O’Brien
Project title: Host-Microbe Interactions in Crohn’s
Disease
67
Intensive Care Research
The Intensive Care Research and Data Office has
three full-time equivalent Research Coordinators
and supports the conduct of more than 20 studies
– including an afterhours service. Studies include
a wide variety of investigator initiated as well as
industry and pharmaceutical sponsored in the
critical care environment. The group also provides
ongoing support to a significant number of medical
students, junior and senior doctors and allied
health researchers, including an increasing number
of PhD students.
We are a member of the ANZICS (Australia and
New Zealand Intensive Care Society) Clinical Trials
Group and participate in the peer review of studies,
participate in research and export data on all
admissions to the unit.
Achievements in 2013–2014 included a large
number of invited international presentations
and invitations for membership of management
committees for large international studies. One
example was that Associate Professor Frank van
Haren with RN Helen Rodgers and RN Rebecca
Millar were the Australia/New Zealand Coordinators
of a global study with ESICM (European Society of
Intensive Care Medicine), and successfully recruited
20 hospitals for this study. The first of a number
of publications based on this study is expected to
appear in JAMA in the second half of 2015.
The ICU Research and Data Office nurses were
nominated for a Nursing and Midwifery Team
Excellence Award in 2014.
Staff
Associate Professor Frank van Haren, Director of
Intensive Care Research; Chair ICU Research
Executive Committee (REX); Medical Director
DonateLife ACT
Dr Bronwyn Avard, Director of Intensive Care
Professor Imogen Mitchell, ICU Consultant; DeputyDean ANU Medical School
Dr Sean Chan, ICU Consultant
Dr Marta Kot, ICU Consultant
Dr Anne Leditschke, ICU Consultant
Dr Sumeet Rai, ICU Consultant
Dr Manoj Singh, ICU Consultant
Dr Kelvin Grove, ICU Consultant; Clinical Director,
Dr Simon Robertson, ICU Consultant
Dr Peter Velloza, ICU Consultant
Ms Helen Rodgers, Registered Nurse ICU Research
Coordinator
Mrs Rebecca Millar, Registered Nurse ICU Research
Coordinator
Mrs Elise Taylor, Registered Nurse ICU Research
Coordinator
Mrs Mary Nourse, Registered Nurse ICU Research
Coordinator
Ms Louise Herlihy, ICU Nutritionist
Mrs Bernie Bissett, Senior Physiotherapist, Canberra
Hospital; Clinical Assistant Professor, Discipline of
Physiotherapy, University of Canberra
Ms Margot Green, Cardiorespiratory Clinical
Educator Physiotherapist, Canberra Hospital
Mr Vince Marzano, HP3 ICU Physiotherapist,
Canberra Hospital
Mrs Maja Leech, HP2 Physiotherapist, Canberra
Hospital
68
Students
Ms Lori Delaney, PhD, Australian National University
Supervisor: Associate Professor Frank van Haren
Ms Louise Herlihy, PhD, Australian National
University
Mrs Bernie Bissett, PhD, University of Queensland
Supervisors: Dr Jenny Paratz (UQ), Dr Rob Boots
(UQ), Dr Anne Ledtischke
Dr Liam Byrne, PhD, Australian National University
Mr Sean Dicks, PhD, University of Canberra
Mr Alex Pavli, BMBBS, Australian National University
Supervisor: Dr Bronwyn Avard
Mr Ken Hoffman, CICM research project, Canberra
Hospital
Ms Ashley Woods, BMBBS, Australian National
University
Ms Kate Rampe, BMBBS, Australian National
University
Mr Ryan Burns, BMBBS, Australian National
University
Supervisor: Dr Bronwyn Avard
Ms Annelise Kerr, BMBBS, Australian National
University
Mr Joel McVey, BMBBS, Australian National
University
Dr Siddharth Goswami, CICM research project,
Canberra Hospital
Dr Yong Lee, CICM research project, Canberra
Hospital
Dr Emily Balmaks, JMO, Canberra Hospital
Dr Amy Chong, BMBBS, Australian National
University
Supervisor: Dr Peter Velloza
Visitors
Dr Anthony Delaney, Royal North Shore Hospital
(ANZICS – Australian and New Zealand
Intensive Care Society)
Research projects
Project title: EPO-TBI – Erythropoietin in
Traumatic Brain Injury
Principal investigator: F van Haren
Project title: ART PN – Australasian Registry for
the use of Parenteral Nutrition
Funding source: Fresenius Kabi
Project title: IMT – Inspiratory Muscle Training
Principal investigator: B Bissett
Fund
Project title: Point Prevalence Project
Funding source: Donation from The George
Institute
Project title: REACT Shock
Project title: TRANSFUSE
Project title: Nebulised Heparin
Funding source: BUPA
Project title: International Nutrition Survey
Principal investigator: S Rai
Project title: CAPA Cognitive and Psychosocial
Assessment of Mechanically Ventilated ICU Patients
Fund
Project title: TARGET
Principal investigator: S Rai
Awards
CHARM 2014 – Best Allied Health Oral
Presentation
Mrs Bernie Bissett
Best Paper, ACT Australian Physiotherapy
Mrs Bernie Bissett
69
Grants
Recipient: D Bulic
Fund
Project title: CAPA Study (Cognitive and
Psychosocial Assessment of Mechanically Ventilated
Intensive Care Patients: Does an Experience of
Delirium make a Difference)
Recipient: F van Haren (HEAT Investigator Group)
Funding source: HRC, New Zealand
Project title: HEAT Study
Recipient: B Bissett
Fund
Project title: IMT Study (Inspiratory Muscle Training)
Recipient: F van Haren
Funding source: Fresenius Kabi
Project title: ART PN Australasian Registry of the
use of Parenteral Nutrition
Recipient: S Rai
Fund
Project title: PRICE Study
Recipients: B Bissett, M Green
Project title: ICU Follow Up Clinic Project
Recipient: M Green
Project title: GoSAM (Early Mobilisation in ICU)
Recipient: V Marzano
Project title: Ventilator Hyperinflation Project
70
Liver Research
The Liver Research Group was established in
January 2006 and is affiliated with the ANU Medical
School and Canberra Hospital Gastroenterology
and Hepatology Unit (GEHU). It has been
continuously funded by NHMRC and other
external bodies since its inception and is recognised
internationally for discoveries from highly original
clinical and laboratory-based research. Research
training is a strength of the group with the present
involvement of three PhD students. Former students
and post-doctoral fellows have won at least ten
prestigious scholarships/prizes and Young Investigator
Awards. Several medical student projects are
supervised each year. Current areas of research are
the pathogenesis of non-alcoholic fatty liver disease
(NASH), particularly roles of cholesterol lipotoxicity
and pattern recognition receptors for inflammatory
recruitment and fibrosis. The group also conducts
clinical studies of non-alcoholic fatty liver disease
in type 2 diabetes and outcomes of antiviral
treatment of hepatitis B and hepatitis C, as well as
laboratory investigation into the mechanisms and
hepatoprotective therapies for ischemia-reperfusion
injury of the liver, and pathogenesis of liver cancer in
obesity and with high fat and high cholesterol diets.
The Liver Research Group enjoyed another
successful year. Notable achievements include
successful applications for Category 1 external
competitive grant funding, well-received invited
lectures at national and international scientific
meetings and several publications in peer-reviewed
journals. Dr Auvro Mridha, a junior postdoctoral
fellow was short-listed for a Young Investigator
Award at the 2014 Australian Gastroenterology
Week meeting and three PhD students are
well on the road to completion in the next 12
months. In 2014, Professor Narci Teoh was elected
as Chair of the Gastroenterological Society of
Australia (GESA)’s Research Committee (RC).
She currently oversees a panel of ten GESA
RC members and actively manages a research
portfolio for GESA, which encompasses hepatology,
endoscopy, inflammatory bowel disease, nutrition
and neurogastroenterology research. GESA’s RC
administers more than $500,000 per annum worth
of scholarships, fellowships and grants and is very
active in raising the profile of GESA, the importance
of gastroenterology and hepatology research in the
Asia Pacific region and Australia at several levels
including public awareness, the NHMRC and the
Federal Government.
71
Staff
Professor Geoff Farrell, Senior Staff Specialist, GEHU;
Professor of Hepatic Medicine, ANU Medical
School
Professor Narci Teoh, Senior Staff Specialist, GEHU;
Professor of Medicine, ANU Medical School
Associate Professor Shiv Chitturi, Senior Staff
Specialist, GEHU
Dr Sharon Pok, PhD, Research Officer
Dr Derrick van Rooyen PhD, Research assistant
Mr Auvro Mridha, Research Officer
Ms Vanessa Barn, Technical Officer
Ms Teddi Dwyer, Project Officer
Ms Jess Hope, Project Officer
Dr Brenda Chen MD, Research Assistant
Students
Dr Lay Theng Gan, MBBS, PhD, Australian National
University (NHMRC)
Supervisors: Professor Geoff Farrell,
Professor Narci Teoh
Mr Fahrettin Haczeyni, PhD, Australian National
University
Dr Arfianti Arfianti, MD, PhD, Australian National
University (Aus AID)
Grants
Recipients: N Teoh, G Farrell
Project title: Micro-Particles and Liver Ischemia
Reperfusion Injury
Recipients: G Farrell, N Teoh
Project title: Micro-Particles in NASH: Origins,
Pathogenic Roles and Biomarkers of Disease Activity
Recipient: N Teoh
Project title: p53 and Hepatocyte Proliferation in
Chronic Liver Disease
Recipients: N Teoh, G Farrell
Project title: Protecting Fatty Livers from Hepatic
Ischemia-Reperfusion Injury in Liver Surgery and
Transplantation
Recipients: G Farrell, S Chitturi, N Teoh
Funding source: Phillip Bushell Foundation
Project title: Identifying Patients with Fatty Liver
Disease who will Develop Cirrhosis or Liver
Cancer, and Discovering way to Prevent these
Complications
Recipients: C Nolan, G Farrell
Project title: Role of Islet β-Cell Failure in the
Pathogenesis of Non-Alcoholic Steatohepatitis
72
Medical Assessment and Planning
Staff in the Medical Assessment and Planning
Unit conduct research in a number of different
fields, including clinical health service delivery,
epidemiology, infectious diseases, aged care medicine
and metabolic disorders. Medical students from the
ANU Medical School are routinely supervised for
their research projects. We are currently involved
in improving processes that optimise patient flow
and coordination of care on medical wards and
have presented some of our findings at a national
conference.
Staff
Dr Ashwin Swaminathan, Director, Medical
Assessment and Planning Unit; Senior Lecturer,
ANU Medical School
Dr Jonathan Bromley, Physician, Medical Assessment
and Planning Unit; Clinical Lecturer, ANU Medical
School
Dr Carolyn Petersons, Physician, General Medicine
Unit
Dr Mary Ann Kulh, Physician, Medical Assessment
and Planning Unit; Clinical Lecturer, ANU Medical
School
Grants
Recipients: A Swaminathan, R Lucas
Funding source: Cancer Council Australia
Project title: Sun Exposure and Vitamin D Study
(SEDS)
73
Medical Oncology
The Medical Oncology Research
Unit has been involved in the
conduct of oncology studies
exploring new drugs and
treatments across a broad
range of different cancers.
Partnerships have been formed
with pharmaceutical companies,
cooperative clinical trials groups as
well as national and international
academic collaborators in this
research. The unit has participated
in many important Phase III
registration trials of new agents
including biologicals that have now
become standard of care. Recent
collaborations have been in the areas of supportive
care, cancer survivorship, Indigenous health,
biobanking and translational research.
Staff
Associate Professor Desmond Yip, Director, Medical
Oncology Research Unit; Clinical Director,
Department of Medical Oncology; Senior
Staff Specialist in Medical Oncology; Associate
Professor, ANU Medical School; Adjunct Associate
Professor, University of Canberra; Honorary
Associate, Sydney Medical School, University of
Sydney
Associate Professor Paul Craft, Director, Division
of Cancer, Ambulatory Care and Community
Health Support; Senior Staff Specialist in Medical
Oncology; Associate Professor, ANU Medical
School
Professor Robin Stuart Harris, Senior Staff Specialist
in Medical Oncology; Professor of Medical
Oncology, ANU Medical School
Dr David Leong, Senior Staff Specialist in Medical
Oncology, Senior Lecturer, ANU Medical School
Dr Alison Davis, Senior Staff Specialist in Medical
Oncology, Senior Lecturer, ANU Medical School
Dr Nicole Gorddard, Senior Staff Specialist in
Medical Oncology, Lecturer, ANU Medical School
Dr Ganesalingham Pranavan, Staff Specialist in
Medical Oncology, Lecturer, ANU Medical School
Dr Yu Jo Chua, Staff Specialist in Medical Oncology,
Senior Lecturer, ANU Medical School
Dr Sayed Ali, Staff Specialist in Medical Oncology,
Lecturer, ANU Medical School
Mrs Olive Doig, Clinical Trials Manager
Mrs Anne Ryan, Clinical Trials Coordinator
Ms Jody Berry, Clinical Trials Coordinator
Mr Edward Craft, Clinical Trials Administrative
Assistant
Students
Mr Shiva Prakash, MChD, Australian National
University
Supervisors: Associate Professor Hany Elsaleh,
Associate Professor Desmond Yip,
Dr Alesia Ivashkevich
Ms Gemma Curry, MChD, Australian National
University
Supervisors: Dr Ganesalingham Pranavan,
Associate Professor Desmond Yip
Ms Jenny Chen, MChD, Australian National
University
Supervisor: Associate Professor Desmond Yip
Mr Adel Shahnam, MChD, Australian National
University
Supervisor: Dr Sayed Ali
Mr Hamed Shahnam, MChD, Australian National
University
Supervisor: Dr Sayed Ali
Mr Mohammad Cheik-Hussein, MChD, Australian
National University
Supervisors: Associate Professor Desmond Yip,
Dr Yada Kanjanapan
74
Collaborators
Associate Professor Sudha Rao, University of
Canberra
Dr Kate Pumpa, University of Canberra
Associate Professor Gail Garvey, Menzies School of
Health Research
Dr Richard Quek, National Cancer Centre
Singapore
Dr Chee Lee, Prince of Wales Hospital, Randwick
Professor Afaf, UNSW
Visitors
Dr Gerhardt Attard, Royal Marsden Hospital,
London UK
Research projects
COMMERCIAL STUDIES
Project title: MAGE-A3 – Double-Blind, PlaceboControlled Phase III Study to Assess Efficacy
of Recmage-A3+AS15 Antigen Specific Cancer
Immunotherapeutic as Adjuvant Therapy in
Patients with Resectable MAGE A3 Positive NonSmall Cell Lung Cancer
Principal investigator: D Leong
Funding source: GSK
Project title: Millennium – A Phase 3, Randomized,
Double-Blind, Multicenter Trial Comparing TAK700 Plus Prednisone with Placebo Plus Prednisone
in Patients with Chemotherapy-Naïve Metastatic
Castration-Resistant Prostate Cancer
Principal investigator: P Craft
Funding source: TAKEDA
Project title: COU-AA-302 – A Phase III,
Randomised, Double-Blind, Placebo Controlled
Study of Abiraterone Acetate Plus Prednisone in
Asymptomatic or Mildly Symptomatic Patients with
Metastatic Castration Resistant Prostate Cancer
Principal investigator: D Yip
Funding source: Janssen Research and Development
Project title: PROSELICA – Randomised, OpenLabel, Multi-Centre Study Comparing Cabazitaxel
at 20 Mg/M2 and at 25 Mg/M2 Every 3 Weeks in
Combination with Prednisone for the Treatment of
Metastatic, Castration Resistant Prostate Cancer
Previously Treated with Docetaxel-Containing
Regimen
Funding source: Sanofi
Project title: RESILIENCE – A Phase III
Randomised Double Blind Placebo Controlled
Trial Comparing Capecitabine + Sorafenib vs
Capecitabine + Placebo in the Treatment of Locally
Advanced or Metastatic HER-Negative Breast
Cancer
Funding source: Bayer
Project title: AA-EAP – An Open- Label Study of
Abiraterone Acetate in Subjects with Metastatic
Castration-Resistant Prostate Cancer who have
Progressed after Taxane-Based Chemotherapy
Funding source: Janssen-Cilag
Project title: ASCENT – An Australian
Translational Study To Evaluate The Prognostic
Role Of Inflammatory Markers in Patients with
Metastatic Colorectal Cancer Treated with
Bevacizumab (Avastin TM)
Funding source: Roche
Project title: SQUIRE – A Randomised Multicentre
Open Label Phase III Study of GemcitabineCisplatin Chemotherapy Plus Necitumumab (IMC11F8) Versus Gemcitabine-Cisplatin Chemotherapy
Alone in the First-Line Treatment of Patients with
Squamous Stage IV Non-Small Cell Lung Cancer
(NSCLC)
Funding source: GSK
Project title: CATChEz – Continuous Access to
Advanced and Metastatic Renal Cell Carcinoma
Therapy with Everolimus Post Pazopanib
Treatment
Funding source: GSK
Project title: MEK113487 – Randomised, doubleBlind Placebo-Controlled Phase II Study of the MEK
Inhibitor GSK1120212 Plus Gemcitabine vs Placebo
Plus Gemcitabine in Subjects with Metastatic
Pancreatic Cancer
Funding source: GSK
Project title: MEK114267 – A Phase III Randomised
Open-Label Study Comparing GSK1120212 To
Chemotherapy in Subjects with Advanced or
Metastatic BRAF V600E/K Mutation Positive
Melanoma
Funding source: GSK
Project title: PICASSO – A Phase III, Multicentre,
International, Randomized, Double Blind, PlaceboControlled Study of Doxorubicin Plus PalifosfamideTris vs Doxorubicin Plus Placebo in Patients with
Front-Line Metastatic Soft Tissue Sarcoma
Principal investigator: YJ Chua
Funding source: Ziopharm
Project title: AFFINITY – A Randomised Phase
3 Study Comparing Cabazitaxel/Prednisone
in Combination with Custirsen (OGX-011)
to Cabazitaxel/Prednisone for Second-Line
Chemotherapy in Men with Metastatic Castrate
Resistant Prostate Cancer
Funding source: OncoGenex
Project title: PERUSE – A Multicentre, OpenLabel, Single-Arm Study of Pertuzumab in
Combination with Trastuzumab and a Taxane in
First Line Treatment of Patients with HER2-Positive
Advanced (Metastatic or Locally Recurrent) Breast
Cancer
Principal investigator: R Stuart-Harris
Funding source: Roche
Project title: Everexes – A Phase Iiib, Multi-Centre,
Open-Label, Expanded Access Study of Everolimus
(RAD001) in Combination with Exemestane
in Post-Menopausal Women with Estrogen
Receptor Positive, Human Epidermal Growth
Factor Receptor 2 Negative Locally Advanced or
Metastatic Breast Cancer
Funding source: Novartis
Project title: DETERMINE – A Phase 2,
Randomized, Double-Blind Study Comparing
Tremelimumab to Placebo in Second- or Third-Line
Treatment of Subjects with Unresectable Pleural or
Peritoneal Malignant Mesothelioma
Funding source: MedImmune
Project title: PROSPER – A Multinational Phase
III Randomised Double Blind Placebo Controlled
Efficacy and Safety Study of Enazlutamide in
Patients with Non Metastatic Castration Resistant
Prostate Cancer
Funding source: Medivation/Astellas
Project title: APACT – A Phase 3, Multicentre,
Open-Label, Randomised Study of NAB®Paclitaxel Plus Gemcitabine Versus Gemcitabine
Alone as Adjuvant Therapy in Subjects with
Surgically Resected Pancreatic Adenocarcinoma
Funding source: Celgene International
Project title: JANUS-1 – A Randomized,
Double‑Blind, Phase 3 Study of the JAK1/2
Inhibitor, Ruxolitinib or Placebo in Combination
with Capecitabine in Subjects with Advanced
or Metastatic Adenocarcinoma of the Pancreas
who have Failed or are Intolerant to First-Line
Chemotherapy
Funding source: Incyte
Project title: IMAGE – A Multi-National,
Prospective, Observational Study in Patients with
Unresectable or Metastatic Melanoma
Principal investigator: S Ali
Funding source: BMS
Project title: DESCRIBE II – Dabrafenib –
Trametinib Combination Metastatic Melanoma
Named Patient Programme Retrospective Chart
Review
Funding source: GSK
COOPERATIVE GROUP TRIALS
Project title: SOFT – A Phase 3 Trial Evaluating
the Role of Ovarian Function Suppression and
the Role of Exemestane as Adjuvant Therapies
for Pre‑Menopausal Women with Endocrine
Responsive Breast Cancer
Principal investigator: A Davis
Funding source: ANZBCTG
Project title: BRAIN-TRAIN – Evaluation of a
Web-Based Cognitive Rehabilitation Program
in Cancer Survivors Web-Based Cognitive
Rehabilitation Program In Cancer
Funding source: University of Sydney
Project title: PACT – Preferences for Adjuvant
Chemotherapy (ACT) in Non-Small-Cell Lung
Cancer: What makes it Worthwhile to Patients
and their Doctors? Observational Cohort Study of
Patients, Surgeons and Oncologists.
Project title: REGISTER – A Multicentre Phase
II Study of Risk Evaluation in GIST with Selective
Therapy Escalation for Response
Funding source: AGITG
Project title: SYMPTOM BENEFIT –
An Observational Study Measuring Subjective
Patient Benefit Associated with Palliative Treatment
in Platinum Resistant Ovarian Cancer
Funding source: ANZGOG
75
76
Project title: SORCE – A Phase III Randomised
Double-Blind Study Comparing Sorafenib with
Placebo in Patients with Resected Primary Renal
Cell Carcinoma at High or Intermediate Risk of
Relapse
Funding source: ANZUP
Project title: PS3BEP – Phase III Accelerated
BEP Trial: A Randomised Phase III Trial of
Accelerated versus Standard BEP Chemotherapy
for Participants with Intermediate and Poor Risk
Advanced Germ Cell Tumours
Principal investigator: G Pranavan
Funding source: ANZUP
Project title: SCOT: Short Course Oncology
Therapy – A Study of Adjuvant Chemotherapy in
Colorectal Cancer (12 Weeks versus 24 Weeks
Oxaliplatin and 5FU)
Funding source: AGITG Cancer Australia
Project title: ICON8 – An International Phase
III Randomised Trial of Dose-Fractionated
Chemotherapy Compared to Standard 3 Weekly
Chemotherapy, Following Immediate Primary
Surgery or as Part of Delayed Primary Surgery, for
Women with Newly Diagnosed Epithelial Ovarian,
Fallopian Tube or Primary Peritoneal Cancer
Project title: GAP – A Phase II Study of PreOperative Gemcitabine and Nab-Paclitaxel for
Resectable Pancreas Cancer
Funding source: Celgene
Project title: PAN1 – A Randomised Phase II Study
Evaluating Potential Predictive Biomarkers in the
Treatment of Metastatic Pancreatic Cancer
Funding source: AGITG/Adnan Nagriel Foundation
Project title: ctDNA – Circulating Tumour DNA as
a Marker of Occult Disease in Stage II Colorectal
Cancer and Response to Therapy in Metastatic
Colorectal Cancer
Funding source: NHMRC; Ludwig Institute
Project title: INTEGRATE – A Randomised Phase
II Double-Blind Placebo-Controlled Study of
Regorafenib in Refractory Advanced OesophagoGastric Cancer (AOGC)
Funding source: AGITG
Project title: PARAGON – A Phase II Study of
Aromatase Inhibitors in Women with Potentially
Hormone Responsive Recurrent/Metastatic
Gynaecological Neoplasms
Project title: Morab-004 – A Phase II Study of
the Safety and Efficacy of the Combination of
Gemcitabine and Docetaxel with Morab-004 in
Metastatic Soft Tissue Sarcoma
Funding source: Morphatek
Project title: Mitotane TDM – Mitotane
Pharmacodynamics in Adrenocortical Cancer in
Children and Adults
Funding source: University of Newcastle
Project title: A Randomised Controlled Trial
Evaluating an Internet Self Help Program (‘Finding
My Way’) for Cancer-Related Distress
Funding source: NHMRC/Finders University
Project title: Patterns of Care Among Australian
Cohort of Patients with Advanced Renal Cell
Carcinoma Receiving Therapy with Sutent
Funding source: Pfizer/BioGrid
OTHER FUNDING SOURCES
Project title: Breast Cancer Tissue Bank –
Collection of Breast Tissue, Serum and Clinical
Data Part of Collaborative Project with
Westmead Millennium Institute with Six Other
Collection Centres in NSW to Provide a Valuable
Biospecimen Resource for Translational Research
Funding source: Radiation Oncology Private
Practice Trust Fund
Project title: Platinum-Based Doublet
Chemotherapy Toxicity in Elderly Patients with
Advanced Non-Small Cell Lung Cancer
Project title: The Incidence of Capecitabine
Related Gastrointestinal Toxicity Among Metastatic
Colon Cancer and Metastatic Breast Cancer
Patients seen in Clinical Practice
Principal investigator: G Pranavan
Project title: A Multicenter Audit of the Incidence
of Febrile Neutropenia and Neutropenia
Associated with Docetaxel and Cyclophosphamide
(TC) Chemotherapy for Early Breast Cancer
Principal investigator: R Stuart-Harris
Funding source: Amgen
77
Project title: Multicentre Prospective Study of
Clinical Outcomes and Analysis of Bevacizumab
Use in Metastatic Colorectal Cancer as part of
Biogrid Collaboration
Funding source: BioGrid
Australia and New Zealand Urogenital and
Prostate Cancer Trials Group (ANZUP)/Bayer
Travel Fellowship to the ANZUP Annual Scientific
Meeting
Dr Yada Kanjanapan
Project title: Validation of and correlation between
different risk stratification models in predicting
outcomes of resected gastrointestinal stromal
tumours (GISTs) treated in an Australian centre
Principal investigators: D Yip, Y Kanjanapan
Grants
Project title: Influence of GIST Genotypes on
Recurrence Risk in Patients with Completely
Resected GIST, A Multicentre Asia Pacific Study
Project title: Effectiveness of Multidisciplinary Team
Meeting in the Management of Stage III Non-Small
Cell Lung Cancer
Awards
Boehringer Ingelheim Educational Grant to attend
World Lung Cancer Congress 2013
Mr James Kuo
Bristol-Myers Squibb Trainee Travel Award to
attend Medical Oncology Group of Australia
(MOGA) Annual Scientific Meeting, 2014
Mr James Kuo
Clinical Oncology Society of Australia Trainee
Travel Grant to attend COSA Annual Scientific
Meeting 2014
Mr James Kuo
Clinical Oncology Society of Australia Trainee
Travel Grant 2013
Mr James Kuo
Clinical Oncology Society of Australia Annual
Scientific Meeting, Best of the Best Oral
Presentation Award in Education, 2014
Dr Yada Kanjanapan
Boehringer Ingelheim Educational Grant to attend
American Society of Clinical Oncology Annual
Scientific Meeting 2013
Dr Yada Kanjanapan
Bristol-Myers Squibb Trainee Travel Award to
attend Medical Oncology Group of Australia
(MOGA) Annual Scientific Meeting, 2014
Dr Yada Kanjanapan
Recipients: C Clarke, R Balleine, R Baxter, S Braye,
J Dahlstrom, J Forbes, C Soon Lee, D Marsh,
A Morey, N Pathmanathan, R Scott, A Spigelman,
R Sutherland, N Wilcken, D Yip
Project title: Breast Cancer Biospecimen Resource,
Australian Breast Cancer Tissue Bank
Grant amount: $1,600,000 (5 years)
Recipients: A Haydon, J Zalcberg, E Walpole, D Yip,
T Price, K Howard, M Jefford
Funding source: Cancer Australia Priority Driven
Collaborative Cancer Research Scheme 2010
Project title: CACTUS and OCTO Groups: Short
Course Oncology Therapy – A Study of Adjuvant
Chemotherapy in Colorectal Cancer
Recipients: D Yip, J Dahlstrom, A Rezo
Funding source: Radiation Oncology Private
Practice Fund
Project title: Breast Cancer Tissue Bank: ACT
Collection Centre 2013, 2014
Grant amount: $30,000 per annum
Recipient: D Yip
Funding source: Monaro Cancer Research
Committee 2014
Project title: The Canberra Hospital Medical
Oncology Research Unit
78
Microbiology
The Microbiology Department of ACT
Pathology conducts research projects
in clinical microbiology involving local
researchers and various international,
national and student collaborators.
The main areas of interest include
antimicrobial resistance, epidemiology of
infection and hospital infection control.
Dr Karina Kennedy and Professor
Peter Collignon are members of the
International Bacteremia Surveillance
Collaborative, which is an active group
investigating the epidemiology of
bacteraemia on a population basis with
projects in Haemophilus influenzae,
Salmonella sp, Fusobacterium sp, Listeria
monocytogenes, Streptococcus agalactiae,
Staphylococcus aureus, Enterocococcus species and
Campylobacter sp.
The Microbiology Department is a longstanding
participant in the Australian Group on Antimicrobial
Resistance, a Commonwealth of Australia funded
project to monitor and report on antimicrobial
resistance trends across Australia, with Professor
Peter Collignon an executive member of the
group. Dr Kennedy and Dr Heather Wilson are
currently collaborating with the Australian and
New Zealand Mycology Interest Group (ANZMIG)
Australian Candidaemia Survey, aimed at describing
the microbiology incidence, clinical features and
outcomes of Candidaemia across Australia, and have
recently completed a Non-Aspergillus mould study
with the same group.
The Microbiology Department has established links
with Professor David Gordon at the Australian
National University and Dr Hanna Sidjabat at the
University of Queensland, with several projects
related to enteric flora, Escherichia coli in humans
and animals, genome sequencing and antimicrobial
resistance. Dr Anindita Das is currently working
as an ANU Fellow and investigating the role
of sonication in improving the microbiological
diagnosis in prosthetic device infections. Students
of the ANU Medical School have been actively
involved in research projects with the Department
of Microbiology over several years, resulting in
several publications and conference presentations.
Dr Karina Kennedy is also supervising PhD
student Mr Cameron Moffatt in the area of
Campylobacter sp infection epidemiology.
Staff
Dr Karina Kennedy, Acting Director
Professor Peter Collignon AM, Executive Director,
ACT Pathology; Clinical Microbiologist and
Infectious Diseases Physician
Dr Anindita Das, ANU Fellow, Clinical Microbiologist
Dr Heather Wilson, Microbiology Registrar,
Advanced Trainee Microbiology and Infectious
Diseases Registrar
Mrs Susan Bradbury, Chief Scientist Microbiology
Ms Cherie O’Brien, Senior Scientist (Acting)
Microbiology
79
Students
Ms Sharna Naughton, MBBS, ANU Medical School
Ms Laura Casey, MBBS, ANU Medical School
Ms Rebekka Jergen, MBBS, ANU Medical School
Ms Caren Laubscher, MBBS, ANU Medical School
Ms Eilidh Gilritchie, MBBS, ANU Medical School
Ms Shiwei Huang, MBBS, ANU Medical School
Grants
Recipient: A Das
Fund
Project title: Improving Microbiological Diagnosis of
Prosthetic Orthopaedic Device Infections: The Role
of Sonication
Recipient: C Laubscher
Funding source: Royal College of Pathologists
Australasia Scholarship in Pathology for Medical
Schools 2013
Project title: Evaluation of Environmental Cleaning
Efficiency in the Canberra Hospital using Three
Modalities
Grant amount: $2, 000
Recipient: E Gilritchie
Fund Summer Scholarship
Project title: Evaluating the Effectiveness
of Screening for Carbapenem Resistant
Enterobacteriaeceae (CRE) Following an
Outbreak of CRE Associated with Environmental
Contamination
Recipient: ACT Pathology Department of
Microbiology
Funding source: Australian Commonwealth
Project title: Australian Group on Antimicrobial
Resistance
Grant amount: $200,000 (distributed between
35 participating laboratories) per annum
80
Neonatology
Research is immersed
in the philosophy of the
Department of Neonatology
at the Centenary Hospital
for Women and Children.
Since the beginnings of
neonatal research we have
seen dynamic changes in
technology, pharmacology
and nursing care that have
improved the short- and longterm outcomes of neonates
worldwide. We endeavour to
provide evidence-based care in
our unit through fostering high
quality neonatal research in the
Intensive and Special Care Units. The Department
of Neonatology fosters a collaborative approach
in supporting research. Medical and nursing staff
are encouraged to actively participate in local and
international research studies. Our team prides
itself in developing and coordinating research to
facilitate neonatal care in the unit. We welcome
staff bringing their ideas to our research group
and developing projects to investigate their ideas.
The department maintains a strong representation
at local and international research meetings,
disseminating research findings and knowledge to
instigate evidence-based practice in the NICU. All
research conducted in the NICU has the approval
of the ACT HREC and is overseen by the Neonatal
Academia and Research Group.
The department also collaborates with national
and international research institutions including: the
Australian National University, the University of
Canberra, Australian Catholic University, University
of Queensland, Sydney University, Monash University
and Children’s Hospital of Eastern Ontario.
The current research projects in the NICU
include: Australian Placental Transfusion Study
(APTS), Lactoferrin Infant Feeding Trial (LIFT),
Paracetamol Duct Action (PDA), Central blood
flow measurements in preterm neonates, Renin and
aldoseterone levels in neonates (RENAL study),
Methods of weaning CPAP in infants <30 weeks
gestational age: Follow up study, Family Integrated
Care (FiCare) and the impact of changing the NICU
design on workflow and practice.
Staff
Dr Hazel Carlisle, Clinical Director
Dr Tejasvi Chaudhari, Staff Specialist Neonatologist
Professor Zsuzsoka Kecskes, Senior Staff Specialist
Professor Alison Kent, Senior Staff Specialist
Professor Abdel-Latif Mohamed, Staff Specialist
Associate Professor David Todd, Staff Specialist,
Chief Medical Officer
Mrs Margaret Broom, Neonatal Research Nurse
Students
Mr Andy Hua, MBBS, Australian National University
Supervisor: Professor Zsuzsoka Kecskes
Ms Eileen Baker, MBBS, Australian National
University
Supervisor: Dr Hazel Carlisle
Ms Mara Matic, MBBS, Australian National University
Supervisor: Professor Alison Kent
Ms Violet Inati, MBBS, Australian National University
Supervisor: Professor Alison Kent
Mr Lachlan Facey, MBBS, Australian National
University
Supervisor: Professor Abdel-Latif Mohamed
Ms Dina Kirollos, MBBS, Australian National
University
Ms Lauren French, MBBS, Australian National
University
81
Ms Amy Goh, Master of Epidemiology, University of
Sydney
Ms Claire Johnston, MBBS, Australian National
University
Supervisor: Associate Professor David Todd
Ms Estella Robson, MBBS, Australian National
University
Mr Russell McGoldrick, MBBS, Australian National
University
Supervisor: Associate Professor David Todd
Ms Esther Mitchelson, MBBS, Australian National
University
Ms Holly Powell, MBBS, Australian National
University
Ms Sunita Biswas-Legrand, MBBS, Australian National
University
Ms Arunima Jain, MBBS, Australian National
University
Mr Alex McFarlane, MBBS, Australian National
University
Ms Gemma Curry, MBBS, Australian National
University
Mr Lachlan Angus, MBBS, Australian National
University
Ms Samantha Howard, MBBS, Australian National
University
Mr Bhuwan Paudel, PhD, Australian National
University
Ms Nusrat Homaira, PhD, University of New South
Wales
Ms Louisa Carroll, PhD, University of New South
Wales
Ms Katherine Burkitt, MBBS, Australian National
University
Supervisor: Dr Tejasvi Chaudhari
Ms Natasha Singh, MBBS, Australian National
University
Supervisor: Dr Tejasvi Chaudhari
Research projects
Project title: Panadol for Patent Duct Arteriosus
(PDA)
Principal investigators: H Carlisle, M Broom
Project title: Meeting the Needs of Aboriginal
and Torres Strait Islander Families in a Neonatal
Intensive Care Unit
Principal investigators: H Carlisle, E Baker, M Broom
Project title: Comparison of Neonatal Short
Term Outcomes in Open Bay and Two Cot Room
NICUs
Principal investigators: Z Kecskes, A Hua, M Broom
Project title: Patient Flow in Maternity
Principal investigators: Z Kecskes, A AllermoFletcher
Project title: Australian Placental Transfusion Study
Principal investigator: A-L Mohamed, M Broom
Project title: Lactoferrin Infant Feeding Trial
Principal investigators: A-L Mohamed, M Broom,
D Todd
Project title: Impact of Timing of Birth/Admission
of Term and Preterm Infants on Neonatal
Morbidity, Mortality and Neurodevelopmental
Outcome: Meta-Analysis of Observation Studies
Principal investigators: A-L Mohamed, L Facey
Project title: Impact of ‘Vaginal’ vs ‘Caesarean
Section’ Delivery on Morbidity and Mortality of
Infants with Ante-Natally Diagnosed Gastroschisis:
Meta-Analysis of Observation Studies
Principal investigators: A-L Mohamed, K Burkitt,
D Kirollos
Project title: Impact of ‘Singleton’ vs ‘Multiple’
Birth on Neonatal Morbidity, Mortality and
Neurodevelopmental Outcomes: Meta-Analysis of
Observation Studies
Principal investigators: A-L Mohamed, L French
Project title: Neonatal Regional Brain Volumes and
Structure and Neurodevelopmental Outcome in
Preterm Infants Hospitalized in Different NICU
Environments in ACT
Principal investigators: A-L Mohamed, A Dhayade
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Project title: Audit of Voluntary Incident Reporting
in a Tertiary Neonatal Intensive Care Unit in ACT,
Australia
Project title: Red Light on Retinopathy of
Prematurity (RED – ROP RCT)
Principal investigators: A Kent, M Broom
Fund
Project title: Vitamin D Supplementation in
Preterm Neonates
Principal investigators: A Kent, J McIntosh
Fund
Project title: AWAKEN (Kidney Study)
Principal investigators: A Kent, E Kane
Fund Vacation Scholarship
Project title: Audit of Voluntary Incident Reporting
in a Tertiary Neonatal Intensive Care Unit in ACT,
Australia
Project title: A Prospective Cohort Study
Reviewing Respiratory Outcomes Among Preterm
Infants with or without Chronic Lung Disease
(CLD) with a Nested Randomisation of Weaning of
Continuous Positive Airway Pressure (CPAP)
Principal investigators: D Todd, C Johnson, M Broom
Project title: Tongue Tie Follow up Survey
Principal investigators: D Todd, R McGoldrick
Project title: Trialling the General Electric Shuttle
in the NICU – A Retrospective Audit of Neonates
Transferred to the NICU
Principal investigators: M Broom, M Rosin, L Ehrlich
Project title: A Retrospective Audit of Growth
and Development Clinic Participants < 32 Weeks
Outcomes at 3 Years
Principal investigators: M Broom, H Carlisle
Project title: Family Integrated Care (FICare) –
Staff and Family Focus Groups
Principal investigators: M Broom, G Parsons,
Z Kecskes, H Carlisle
Fund Vacation Scholarship
Awards
2013 ACT Quality in Healthcare Awards in the
Consumer Participation Category for the project
entitled: ‘Parents Participation at Bedside Rounds:
A Cross-Over Randomised Controlled Trial’
This research team included: Associate Professor
Abdel-Latif Mohamed, Ms Danette Boswell,
Mrs Margaret Broom, Professor Deborah Davis,
Associate Professor Zsuzsoka Kecskes, Ms Judith
Smith, Mr Jerome Poblete and Ms Anne Cashel.
The research team was led by Associate Professor
Abdel-Latif Mohamed.
Discoverquick Best Clinical Research poster
presentation 2013: From Novice to Expert Graduate Nurse Education in NICU
L Ehrlich‚ J Bourke, J McEwan, M Broom
Discoverquick Best Clinical Research poster
presentation 2014: CeasIng CPAP at standarD
criteriA (CICADA): Does Implementation into
Practice effect Outcomes?
R Heath Jeffery, D Todd, M Broom, B Shadbolt
CHARM 2013 – runner up, award for most
abstract submissions
Department of Neonatology
83
Grants
Recipient: E Bariciak
Funding source: Physician Services Incorporated
Foundation, Canada
Project title: Renin and Aldosterone in Neonates
(RENAL study)
Recipient: A Kent
Fund; Canberra Hospital Research Office; Newborn
Intensive Care
Project title: Preliminary Evaluation of the Effect of
670nm Red Light on Retinopathy of Prematurity
(RED Light for ROP Study)
Recipient: A-L Mohamed
Fund
Project title: Parental Presence on Bedside Clinical
Rounds (PPBCR) in NICU
Recipient: T Chaudhari
Fund
Project title: Neonatal Hypertension – A Long Term
Follow-Up Study
Recipients: J McIntosh, T Chaudhari, A Kent
Fund
Project title: Vitamin D Supplementation in Preterm
Neonates
84
Neurology
The Neurology Department at Canberra Hospital is
involved in research in a number of different areas.
We are actively involved in clinical projects looking
at stroke, and are collaborating widely to explore
various areas of vision and eye movements as well
as other clinical disorders including stroke, multiple
sclerosis and Parkinson’s disease. We collaborate
with a number of departments at the Australian
National University, University of New South Wales,
and the University of Belfast.
Students
Staff
Professor Ted Maddess, Eccles Institute of
Neuroscience, John Curtin School of Medical
Research
Associate Professor Andrew Neely, UNSW
Canberra
Mr Gawn McIlwaine, University of Belfast, Northern
Ireland, UK
Professor Christian Lueck, Head of Neurology
Department
Dr Andrew Hughes, Senior Staff Specialist
Dr Chandi Das, Senior Staff Specialist
Dr Craig McColl, Senior Staff Specialist
Ms Angela Borbelj, Senior Neurophysiology
Technician
Ms Dawn Nusa, Stroke Liaison Nurse
Mr Paul Adams, Stroke Liaison Nurse
Ms Sally Anne Wherry, Parkinson’s Nurse Specialist
Mr Brendan Tonson-Older, PhD, Australian National
University
Supervisors: Professor Ted Maddess, Dr Jason Bell,
Professor Christian Lueck
Mr Tom Lillicrap, PhD, Australian National University
Supervisors: Professor Christian Lueck,
Associate Professor Andrew Neely
Collaborators
Grants
Recipients: C Lueck, S Jain
Fund
Project title: Microscopic Anatomy of the Normal
Human Optic Chiasm
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Population Health
The Population Health
Division is committed
to protecting and
improving the health
outcomes for the people
of the ACT through the
delivery of public health,
environmental health
and health promoting
activities and services.
There are two branches
in Population Health, as
well as two offices: Health
Improvement Branch,
Health Protection Service, Executive Support
Office and the Office of the Chief Health Officer.
In 2012, the Division drafted the Population Health
Research Strategy 2012–15, providing strategic
direction for population health research in the ACT.
The Strategy focuses on developing a research
agenda, building research capacity for population
health, and developing partnerships with our
academic institutions to support research activities.
Staff
Dr Paul Kelly, Chief Health Officer and Deputy
Director-General
Dr Andrew Pengilley, Senior Specialist and Deputy
Chief Health Officer
Professor Charles Guest, Director of Research
Dr Ranil Appuhamy, Staff Specialist
Dr Ian Whittall, Manager, Toxicology, ACT
Government Analytic Laboratory
Dr Karina Kennedy, Staff Specialist
Dr Stephanie Davis, National Centre for
Epidemiology and Population Health, ANU
Mr James Grech student placement, University of
Canberra
Ms Lily Jenkins, Research Officer
Ms Rosalind Sexton, Senior Data Manager,
Epidemiology
Mr Tony Blattman, Senior Manager, ACT Health
Promotion Grants Program
Ms Ashlea Norton, Student placement, University of
Canberra
Mr Cameron Moffatt, OzFoodNet Epidemiologist,
Communicable Disease Control
Ms Carolyn Banks, Manager, Immunisation,
Communicable Disease Control
Students
Dr Ranil Appuhamy, Master of Applied Epidemiology,
Supervisors: Dr Paul Kelly (PHD), Dr Stephanie
Davis (ANU)
Mr James Grech, BApISc, University of Canberra
Supervisor: Dr Tamsin Kelly (UC)
Ms Lily Jenkins, PhD, Australian National University
Supervisors: Dr Deborah Schaler (PHD), Professor
Kaarin Anstey (ANU)
Ms Rosalind Sexton, BSci, Charles Sturt University
Mr Tony Blattman, Masters of Health Policy,
Supervisor: Dr James Gillespie
Ms Ashlea Norton, BAppISc (Hons), University of
Canberra
Supervisor: Dr Tamsin Kelly
Mr Cameron Moffatt, PhD, Australian National
University
Supervisor: Associate Professor Martyn Kirk
Mr Lucas Mills, Master of Applied Epidemiology,
Supervisor: Rebecca Hundy and Dr Emily Fearnley
86
Collaborators
COLLABORATIVE PARTNERSHIP GRANT
Allen C Cheng, Mark Holmes, Dominic E Dwyer,
Saliya Hewagama, Tony Korman, Louis Irving,
Simon Brown, Grant Waterer, Cameron Hunter,
N Deborah Friedman, Peter Wark, Graham
Simpson, John Upham, Simon Bowler, Kristine
Macartney, Christopher Blyth, Tom Kotsimbos,
Alfred Health; Monash University, University of
Adelaide, Royal Adelaide Hospital, Australian
National University, University of Sydney,
Westmead Hospital, Alice Springs Hospital,
Monash Medical Centre, Royal Melbourne
Hospital, University of Melbourne, University
of Western Australia, Royal Perth Hospital,
University of Tasmania, University Hospital
Geelong, University of Newcastle, John Hunter
Hospital, Cairns Base Hospital, Princess
Alexandra Hospital, University of Queensland,
Mater Hospitals, Children’s Hospital at
Westmead, Princess Margaret Hospital,
University of Western Australia, Telethon Kids
Institute
Dr David Caldicott, Calvary Hospital
Dr Murali Nayudu, Associate Professor (adj),
Centre for Research in Therapeutic Solutions,
Biomedical Sciences, Faculty of Education,
Science & Technology and Mathematics,
University of Canberra
Dr Tamsin Kelly, Assistant Professor, Ms Ashlea
Norton (Student), Faculty of Applied Science,
University of Canberra
Professor Andrew Wilson (Director, Menzies Centre
for Health Policy), Dr Kerry Chant (CHO, NSW
Ministry of Health), Karen Beatty (Director,
HCF), Sara Byrne (National Health and Medical
Research Council), Professor Adrian Bauman
(Professor of Public Health), The National
Health and Medical Research Council, Australian
National Preventive Health Agency, the NSW
Ministry of Health, and HCF Health and Medical
Research Foundation, as well as the Sax Institute,
Menzies Centre for Health Policy, University
of Sydney, Sydney School of Public Health,
Professor Rachel Davey, Professor Helen Berry,
Professor Tony Capon, Centre for Research and
Action in Public Health, University of Canberra
Associate Professor Cathy Banwell, National Centre
for Epidemiology and Public Health, ANU
Ms Sharon Friel and Ms Charmian Bennett, National
Centre for Epidemiology and Public Health,
ANU, and CSIRO
Professor Kaarin Anstey, Dr Chris Hatherley, Project
Manager, Centre for Research on Ageing, Health
and Wellbeing, ANU, National quality dementia
care initiative, Alzheimer’s Australia
Mr Tony Stubbs (CEO) and Ms Erica Nixon (Project
Officer), Heart Foundation
Professor Kaarin Anstey, Dr Nicholas Cherbuin,
Professor Gabriel Bammer, Associate Professor
Peter Butterworth, Ms Lily O’DonoughueJenkins (PhD student), Australian National
University
Professor Rachel Davey, University of Canberra,
ACT Medicare Local, ACT Heart Foundation,
Ochre Health
Associate Professor Sharon Goldfeld, Professor Billie
Giles-Corti, Associate Professor Robert Tanton,
Dr Sally Brinkman, Prof lan Katz, Associate
Professor Geoff Woolcock, University of
Melbourne
Research projects
Project title: Comparing Obesity Prevention
Activities – Canberra and New York
Principal investigators: P Kelly, A Grieg, A Davies,
E Cagan, K Lee, S Kansagra
Project title: Analysis of the Deathcap Mushroom
Amatoxins by UPLC-MS-MS
Principal investigators: T Kelly, I Whittall, J Giaccio,
A Norton
Project title: Healthy Worker Initiative Research
Project: What Roles do Time, Money and Social
Position Play in Driving Participation in a Workplace
Health Promotion Program
Principal investigators: C Banwell, D Broom,
J Dixon, G Sargent, L Strazdins, M Hare, H Lilley,
L Newman
Funding source: Australian National Preventive
Health Agency Grant
Project title: Healthy Urban Systems Research
Program
Principal investigators: Collaboration between
ANU, CSIRO and ACT Health: S Friel, C Bennett,
C Baker
Project title: Ecological Mapping of the
Environment: Associations of Health Behaviour
with Chronic Disease Risk – Informing Better Public
Policy
Principal investigators: R Davey, H Berry, T Capon,
P Kelly, L Halliday
87
Project title: Evaluation of EnzymeLinked ImmunoSorbent Assay and Liquid
Chromatography-Tandem Mass Spectrometry
as Screening and Confirmation Methods for the
Detection of Synthetic Cannabinoids
Principal investigators: J Grech, T Kelly, I Whittall
Project title: Using Hyperpriming, a New DNA
Technology, to Differentiate Bacterial Isolates of
Importance to Health such as Salmonella
Principal investigators: M Nayudu and R Krsteski
Project title: Geographical Variation and Spatial
Analysis of Hospital Admission Rates for Chronic
Diseases across the ACT
Principal investigators: R Davey, X Goldie,
L Halliday, G Wood
Project title: It’s Your Move ACT
Principal investigators: B Swinburne, C Chikwendu
Project title: Improving Methods of Grading,
Transferring and Facilitating Translation of
Knowledge in Population Health
Principal investigators: ANU Centre for Aging
Research and Wellbeing; Alzheimers Australia;
ACT Health
Funding source: ARC Linkage Grant
Project title: Evaluation of the Whole of
Government Healthy Weight Initiative in the ACT
Principal investigators: The Australian Prevention
Partnership Centre and ACT Health
Funding source: ACT Health and The Australian
Prevention Partnership Centre
Project title: Audit of Food and Beverage
Marketing to Children in the ACT
Principal investigators: E Nixon, T Stubbs, L Paton
Project title: Projecting the Effects of Obesity
Reduction on Acute Healthcare Costs in the
Australian Capital Territory
Principal investigators: J Goss, A Pengilley,
E Harper, P Sutton, M McKinnon
Project title: Obesity, Overweight and
Government Regulation – Measuring ACT
Community Attitudes
Principal investigators: Newspoll, A Pengilley,
E Harper, P Sutton, M McKinnon, S Leydon,
L Fritsche
Project title: Using Hyperpriming, a New DNA
Technology, to Differentiate Bacterial Isolates of
Importance to Health
Principal investigators: M Nayudu, R Krsteski
Project title: Surveillance for Shiga-Toxin Producing
Escherichia Coli (STEC) in the Australian Capital
Territory
Principal investigators: C Moffatt, R Hundy,
M Bryce, K Kennedy
Project title: Geographical variation and Spatial
Analysis of Hospital Admission Rates for Chronic
Diseases across the ACT
Principal investigators: R Davey, X Goldie,
L Halliday, G Wood
Awards
2013 Resilient Australia Award – Certificate of
Recognition for Contribution to ACT Natural
Disaster Resilience
Epidemic Infectious Disease Plan Project
Grants
Recipients: ANU; Alzheimer’s Australia and
ACT Health
Funding source: Australian Research Council linkage
grant
Project title: Improving Methods of Grading,
Transferring and Facilitating Translation of Knowledge
in Population Health
Recipients: C Banwell, L Strazdins, J Dixon, D Broom,
M Hare, H Lilley, L Newman
Funding source: Australian National Preventive
Health Agency Grant
Project title: What Roles do Time, Money and Social
Position Play in Driving Participation in a Workplace
Health Promotion Program
88
Radiation Oncology
The Radiation Oncology Department at the
Canberra Region Cancer Centre is committed
to continuous improvement in cancer treatment
by advancing innovative technology and research.
Radiation Oncology aims to provide an environment
where employees are given opportunities to
participate in research activities that ultimately will
have a positive impact on patient care.
Considerable time and effort has been devoted by
personnel in the department in obtaining technical
credentialing and training to support participation
in Trans Tasman Radiation Oncology Cooperative
Group (TROG) multi-institutional clinical trials.
We also encourage local and interstate
departmental collaborations with our ACT Health
and interstate colleagues, universities (eg: ANU,
University of Sydney, Melbourne University, Monash
and the UWA) and clinical research trial groups
(TROG).
Radiation Oncology is participating in international
and clinical and translational trials such as Circulating
Tumour DNA in Rectal Cancer, SCORAD III,
CHISEL, AVIATOR and STARS. Radiation Oncology
trainees and fellows are actively involved in Clinical
Research trials and projects at the department
that enables them to gain research experience, and
enhance their clinical training.
Radiation Oncology also supports the Cancer
Research Laboratory (gastric cancer carcinogenesis)
and participates in local translational research.
Further work is being done to expand
laboratory‑based research for the unit. The
recruitment and support of a Radiation Biologist
allows bridging clinical advances in cancer therapy
with laboratory-based investigations.
In-house research and development collaborative
projects involving the Medical Physics Department
and Radiation Oncology are underway. The efforts
of the Department’s Research and Development
Group facilitates new treatment programs such
as Stereotactic Radiosurgery (cranial and body),
Respiratory Gating for lung cancer and abdominal
malignancies and the increased use of complex
techniques that will reduce toxicity and improve
treatment outcomes.
The Department of Radiation Oncology have been
long-term contributors and supporters of the
longitudinal Breast Cancer Treatment Group project
as well as the Medical Oncology Trials Unit and the
ANU Research CHARM event.
Radiation Oncology is an accredited training site for
medical specialist training of the Royal Australian and
New Zealand College of Radiologists. Our training
program has successfully produced a 100 per cent
completion rate of its trainees. The department
is also involved in the Southern NSW Radiation
Oncology Training Network where trainees rotate
to participant sites. The aim of the program is to
ensure a broader range of experience for the
trainees as well as an exposure to a variety of
clinical scenarios and settings and a range of patients
from many different cultural and socioeconomic
backgrounds. The department registrar teaching
program also involves the training of medical
oncology registrars. Radiation Oncology provides
educational support to the ANU Medical School
as well as elective research and clinical teaching
opportunities for medical students.
The department is actively involved with national
tertiary universities clinical placements for student
radiation therapists as well as providing the training
and supervised practice for intern radiation
therapists to meet the Australian Health Practitioner
89
Regulation Agency requirements for national
accreditation. Radiation therapist training support
is also provided for radiation oncology trainee
registrars and medical physics registrars.
Staff
Associate Professor Hany Elsaleh, Director of
Radiation Oncology
Dr Yu-Yan Fang, Clinical Trial Coordinator
Dr Alesia Ivashkevich, Radiation Biologist
Dr Brandon Nguyen, Radiation Oncologist
Dr Amy Shorthouse, Radiation Oncologist
Dr Lisa Sullivan, Radiation Oncologist
Dr Angela Rezo, Radiation Oncologist
Dr Lyn Austen, Radiation Oncologist
Dr Ken Sunderland, Radiation Oncologist
Dr Roopa Lakhanpal, Radiation Oncologist
Dr Trish Pulvirenti, Radiation Oncologist
Dr Andrew Lee, Radiation Oncology Fellow
Dr Hilde Kleiven, Radiation Oncology Fellow
Dr Neetu Tejani, Radiation Oncology Fellow
Dr Farhan Syed, Radiation Oncology Trainee
Dr Bosco Wu, Radiation Oncology Trainee
Dr Tim Squire, Radiation Oncology Trainee
Dr Sophia Ang, Post Doctoral Research Officer
Dr Mhairi Baird, Post Doctoral Research Officer
Dr Idit Ziv, Post Doctoral Research Officer
Ms Wendy Amos, Chief Radiation Therapist
Ms Kate Francis, Deputy Chief Radiation Therapist
Mr Brett Fittler, Senior Radiation Therapist
Mrs Janelle Hawkins, Senior Radiation Therapist
Mr Brendan Donovan, Radiation Therapist
Ms Leah Oliver, Senior Radiation Therapist
Ms Beni Huang, Radiation Therapist
Ms Claire Stevens, Radiation Therapist
Ms Edna Tsang, Radiation Therapist
Ms Mary O’Connor, Senior Radiation Therapist
Ms Katia Starkey, Radiation Therapist
Ms Lisa Dukes, Radiation Therapist
Mr Glen McPherson, Radiation Therapist
Ms Libby Werner-Gibbings, Radiation Therapist
Mr Dean Panada, Radiation Therapist
Mr Sonny Lai, Radiation Therapist
Ms Lauren Deaves, Radiation Therapist
Ms Trish Banyer, Radiation Therapist
Ms Amy Murphy, Radiation Therapist
Mr Wesley Thom, Radiation Therapist
Ms Stephanie Moffitt, Radiation Therapist
Ms Teri Barker, Senior Radiation Therapist
Ms Jill Li, Radiation Therapist
Ms Kym Allen, Senior Radiation Therapist
Ms Fiona Morgan, Senior Radiation Therapist
Mr John Dugay, Intern Radiation Therapist
Ms Julie O’Rourke, Radiation Oncology Clinical
Nurse Coordinator
Ms Mureen Burnell, Radiation Oncology Nurse
Ms Sally Bray, Radiation Oncology Nurse
Ms Lisa Castle Burns, Radiation Oncology Nurse
Ms Julie Griffin, Radiation Oncology Nurse
Ms Kate Reid, Radiation Oncology Nurse
Mr Peter Langdon, Radiation Oncology Nurse
Mr David Larkin, Research Oncology Nurse
Dr Sean Geoghegan, Chief Medical Physicist
Mr Ben Cooper, Senior Medical Physicist
Mr Ravi Thura, Senior Medical Physicist
Mr Farshid Salehzahi, Medical Physicist
Dr Helen Gustafsson, Medical Physicist
Mr Talat Mahmood, Medical Physicist
Mr Naonori Hu, Medical Physics Registrar
Mr Jon Lee, Medical Physics Registrar
Ms Dalia Hadaya, Medical Physics Registrar
Mr Jason Tse, Medical Physics Registrar
Dr Mounir Ibrahim, Medical Physics Registrar
Mr Deepak Basaula, Medical Physics Registrar
Students
Mr Shiva Prakash, BBiomedSc (Hons), MChD
(Candidate), PhD (Submitted) University of
Queensland, Australian National University
Supervisors: Dr Alesia Ivashkevich, Associate
Professor Desmond Yip, Associate Professor Hany
Elsaleh
Ms Rebecca Colmer, BBiomedSc (Hons), MChD
(Candidate), PhD (Submitted) University of
Queensland, Australian National University
Supervisors: Dr Amy Shorthouse, Dr Farhan Syed
Ms Ellenor Law, RN, BA Honors Psych (ANU) and
UNSW PhD (Candidate), The University of New
South Wales
Supervisors: Professor Afaf Grigiris,
Associate Professor Hany Elsaleh
Research projects
Project title: Assessment of New Radiation
Oncology Technology and Treatments
(ANROTAT)
Principal investigators: L Austen, J Hawkins, H Elsaleh
Project title: Role of Positron Emission Tomography in
the Investigation of Carcinoma of Unknown Primary
Principal investigators: R Colmer, A Shorthouse,
F Syed
90
Project title: Assessment of Acute Skin
Radiotherapy Toxicity in Breast Cancer Using
Quantitative Ultrasound and Correlation to Clinical
Toxicity Grading
Principal investigators: H Kleiven, H Elsaleh,
T Squire, N Tejani, F Syed
Project title: Immunohistochemical 4 Score and
Local Recurrence in Breast Cancer
Principal investigators: R Lakhanpal, A Rezo,
G Bennet, M Brown
Project title: Multicenter Audit of Comprehensive
Geriatric Assessment of Australian Oncology
Patients
Principal investigators: R Lakhanpal, C Steer, D Yip
Project title: Exercise in the Management of
Symptoms from Aromotase Inhibitors in Women
with Breast Cancer
Principal investigators: A Rezo, C Wilder
Project title: Timing Issues in the Management of
Patients with Acute Spinal Cord Compression
Principal investigators: L Sullivan, L Gnanendran
Project title: Omission of Whole Breast Radiation
in Women with Early Breast Cancer
Principal investigators: R Lakhanpal, L Sullivan,
B Shadbolt
Project title: Multicentered Audit of Febrile
Neutropeania associated with TC Chemotherapy
in Breast Cancer
Principal investigators: R Stuart-Harris, R Lakhanpal
Project title: Patient-initiated Outpatient
Management of Low-risk Febrile Neutropenia
Principal investigators: B Shah, H Kleiven,
N Gorddard
Project title: Management of Metastatic Renal Cell
Carcinoma in the Era of Targeted Therapies
Principal investigators: K Webber, A Cooper,
H Kleiven, D Yip, D Goldstein
Project title: Multifocal Breast Cancer and
Locoregional Recurrence
Principal investigators: A Rezo, J Veera
Project title: Retrospective Study of Outcomes for
Locally Advanced Rectal Cancer Patients Treated
with Preoperative Chemoradiation at Canberra
Hospital
Principal investigators: H Kleiven, A Rezo
Project title: Primary Central Nervous System
Lymphoma and Relation to the Hippocampus
Principal investigator: A Lee
Project title: The RANZCR Phase II Planning
Viva Voce Exam- Examples and Advice to aid in
Preparation
Principal investigator: H Kleiven
Project title: Endogenous Iron as an MRI Enhancing
Agent in Tumour
Principal investigators: M Ibrahim, A Ivashkeivch,
S Georhegan
Project title: Triple Negative Breast Cancer and
Loco-Regional Recurrence
Principal investigators: N Tejani, A Rezo
Project title: Analysis Of Local Recurrence in
Multifocal and Multicentric Breast Cancer in the
Australian Capital Territory and South East New
South Wales
Principal investigators: H Kleiven, J Veera, N Tejani,
A Rezo
Project title: Positron Emission Tomography versus
Computer Tomography and Bone Scan for Initial
Staging of Small Cell Lung Cancer
Principal investigators: H Kleiven, A Shorthouse
Project title: ER Stress in Mucous Metaplasia and
Gastric Cancer
Principal investigators: D Taupin, H Elsaleh, M Cook
Project title: Discovery of Potential Synergistical
Interactions between Novel Chemotherapeutical
Agents and Ionizing Radiation
Principal investigators: A Ivashkevich, H Elsaleh
Project title: Investigation into Mechanisms
and Modulation of Toxicity of Chemical
Radioprotectors
Project title: HDACi Mediated Potentiation of
5-FU Radiosensitizing Activity in Colorectal Cells
Principal investigators: A Ivashkevich, S Prakash,
D Yip, H Elsaleh
Project title: Novel Mechanisms of Normal Tissue
Toxicity and Repair
Project title: Breast Cancer Treatment Group
(BCTG) Quality Assurance
Chair: A Rezo
Awards
Poster Prize for Post Radiation Therapy Nurse
Led Clinic at The 3rd Biennial Australian
Capital Region Nursing and Midwifery Research
Conference
Ms Maureen Burnell, Ms Sue Quayle
91
Renal Medicine
The Department of Renal
Medicine is committed to
providing excellence in the care
of people with renal impairment.
Its research interests include
basic renal immunology, clinical
renal research focused on
cardiovascular disease, sleep
disorders and micronutrient
deficiency in patients with
advanced kidney disease. The
department has expertise
and involvement in Cochrane
Systematic reviews in Clinical Nephrology,
Immunology and Transplantation. The department
is involved in health and medical education
research focusing on approaches to support
student and patient learning. The department as a
Member of the Australian Kidney Trials Network
(AKTN) is involved in a number of AKTN
multicentre clinical interventional studies.
Staff
Associate Professor Girish Talaulikar, Clinical Director
Renal Services
Dr Giles Walters, Senior Staff Specialist
Dr Michael Falk, Senior Staff Specialist
Dr Krishna Karpe, Senior Staff Specialist
Dr Richard Singer, Senior Staff Specialist
Associate Professor Darren Roberts, Staff Specialist
Dr Simon Jiang, Staff Specialist
Dr Alice Kennard, Advanced Trainee in Nephrology
Dr Tom Lea-Henry, Advanced Trainee in Nephrology
Ms Patricia Johnson, Clinical Trial Coordinator
Ms Chari Mercado, Clinical Nurse Consultant, Acute
Haemodialysis Unit
Ms Joyce Thanabal, Clinical Nurse Consultant,
Community Dialysis Centre
Ms Anne Maguire, Clinical Nurse Consultant, Renal
Home Therapies Unit
Students
Ms Kathryn McKeon, Bachelor of Medical Science –
Honours, Australian National University
Supervisor: Dr Simon Jiang
Awards
RACP Jacquot NHMRC Award for excellence
Dr Simon Jiang
2014 Endeavour Executive Fellowship: Department
of Education, Australian Government (declined)
Associate Professor Darren Roberts
2013 Denis Wade Johnson & Johnson New
Investigator Award: Australasian Society of
Clinical and Experimental Pharmacologists and
Toxicologists
Associate Professor Darren Roberts
Grants
Recipient: R Singer
Fund
Project title: Cholecalciferol Supplementation in
Kidney Failure: Effect on Quality of Life and Muscle
Strength
Recipient: S Jiang
Funding source: The Vasculitis Foundation
Project title: The Role of Microrna in a Novel
Mouse Model of Vasculitis
Grant amount: 50,000 USD
92
Translational Research Unit
The Translational Research Unit was established in
2009 with the appointment of Professor Matthew
Cook as Director. The aim of the unit is to foster
research collaborations between Canberra
Hospital and the Australian National University,
and strengthen the overall biomedical research
effort at Canberra Hospital. We work on projects
that aim to improve our overall understanding of
human disease. While the core activities of the
unit involve research in immunological disease,
we maintain strong and productive collaborations
with Departments of Immunology (Professor C
Goodnow) and Immunity and Infection (Professor
C Vinuesa) at John Curtin School of Medical
Research, and Dr David Tscharke (Research
School of Biology). At Canberra hospital we have
vibrant and productive collaborations with many
departments, including renal medicine, haematology,
gastroenterology, and division of surgery.
Together with our colleagues we were recently
awarded an NHMRC Centre of Research
Excellence in Personalised Immunology (http://jcsmr.
anu.edu.au/research/cpi). This enables us to further
consolidate our focus on genomic medicine. The
CPI operates simultaneously at the cutting-edge of
biomedical research while implementing genomics
into medical practice.
Our research tackles autoimmune, immune
deficiency, and autoinflammatory diseases, with
the aim of discovering the molecular and cellular
mechanisms of disease. We investigate both rare
cases of Mendelian disease and common immune
diseases. This effort builds on two long-standing
collaborative projects lupus (Australian Point
Mutation in SLE, APOSLE) and primary immune
deficiency (Australian and New Zealand Antibody
Deficiency Study, ANZADA). The centre has
developed the necessary expertise for human
genome analysis, and most projects aim to discover
disease pathways.
Staff
Professor Matthew Cook
Dr Rebecca Sweet, Postdoctoral fellow
Dr Zuopeng Wu, Research assistant
Ms Rochna Chand, Research assistant
Mr Wesley Lam, Research assistant
Dr Gary Chew, Research associate
Ms Anastasia Wilson, Research Nurse
Students
Dr Jalila Alshekaili, PhD, Australian National
University
Ms Cindy Eunhee Lee, PhD, Australian National
University
Dr Elizabeth DaSilva, Clinical Immunologist and PhD,
93
Dr Sam Bennett, Canberra Hospital Research fellow
Dr Scott Hayter, Resident Medical Officer, Masters
Student, Australian National University
Ms Kristy Kwong, Honours, Australian National
University
Ms Clara Young, MBBS, Australian National
University
Ms Sophia Ang, MBBS, Australian National University
Ms Finna Shen, MBBS, Australian National University
Ms Catherine Hayter, MBBS, Australian National
University
Ms Catherine Jun, MBBS, Australian National
University
Collaborators
Professor Paul Gatenby, Immunology
Dr Katrina Randall, Immunology
Dr Carolyn Hawkins, Immunology
Dr Krishna Karpe, Nephrology
Dr James D’Rozario, Haematology
Associate Professor Dipti Talaulikar, Haematology
Professor Walter Abhayaratna, Cardiology
Dr Chandi Perera, Rheumatology
Dr Doug Taupin, Gastroenterology
Professor Paul Pavli, Gastroenterology
Professor Guan Chong, Surgery
Professor Carola Vinuesa, JCSMR
Professor Chris Goodnow, Garvan Institute and
Associate Professor Stuart Tangye, Garvan Institute
Dr David Tscharke, Australian National University
Dr Vicki Athanasopoulos, JCSMR
Dr Julia Ellyard, JCSMR
Associate Professor David Fulcher, University of
Sydney
Associate Professor Sean Riminton, Concord
Hospital and University of Sydney
Professor Diane Campbell, Westmead Children’s
Hospital
Dr Melanie Wong, Westmead Children’s Hospital
Dr Sam Mehr, Westmead Children’s Hospital
Dr Stephen Daley, Monash University
Professor Chris Parish, Australian National University
Dr Sharon Choo, Royal Children’s Hospital,
Melbourne
Dr Kate Nicholls, Royal Melbourne Hospital
Ms Belinda Whittle, JCSMR
Mr Matthew A Field, JCSMR
Professor Martyn French, University of Western
Australia
Dr Theo DeMalmanche, Hunter Pathology
Dr Roger J Garsia, Royal Prince Alfred Hospital,
Sydney and University of Sydney
Associate Professor Stephen Adelstein, Royal Prince
Alfred Hospital, Sydney and University of Sydney
Dr Pravin Hissaria, IMVS and Royal Adelaide
Hospital
Dr Stephen Alexander, Westmead Children’s
Hospital and University of Sydney
Professor Richard Kitching, Monash University
Graduations
Dr Gary Chew, PhD, Australian National University
Ms Dorothya Lestari, BMedSci (Hons), Australian
National University
Ms Neha Gopinath, BSc (Hons), Australian National
University
Research projects
Project title: Australia and New Zealand Antibody
Deficiency Allele Study (Multi-Centre Investigation
of the Genetic and Cellular Basis of a Form of
Primary Immune Deficiency Disease)
Principal investigators: M Cook, D Fulcher,
D Riminton
Project title: Identification of critical Point
Mutations in Patients with Systemic Lupus
Erythematosus
Principal investigators: M Cook, C Vinuesa,
C Goodnow
Project title: Cellular Origin of Non-Hodgkin
Lymphoma
Principal investigators: D Talaulikar, C Goodnow,
M Cook
Fund
94
Project title: Myeloid Lineage-induced Vascular
Pathology
Principal investigators: C Perera, W Abhayaratna,
M Cook, P Gatenby, G Walters, Z Wu
Fund
Phenotyping in Serrated Polyposis
Principal investigators: D Taupin, M Cook
Fund
Project title: The genetic basis of azathioprine
hypersensitivity syndrome
Principal investigators: G Walters, P Pavli, C Jun,
M Cook
Project title: A randomised trial to assess antibody
response to hepatitis B vaccine in patients with
chronic kidney disease
Principal investigators: K Karpe, E Da Silva,
M Cook
Fund
Project title: Response of Circulating T Follicular
Helper Cells to Vaccination
Principal investigators: E Da Silva, A Baker,
K Karpe, M Cook
Project title: Somatic Mutation of B cells in
Sjogren’s Syndrome
Principal investigators: C Goodnow, K Horikawa,
M Cook
Funding source: GlaxoSmithKline
Project title: Genetic and Cellular Analysis of
Autoimmune and Inflammatory Disease
Principal investigators: M Cook, C Vinuesa,
D Fulcher, A Kitching, S Alexander, A Enders
Awards
GlaxoSmithKline Award for Research Excellence
Professor Chris Goodnow
Grants
Recipients: C Goodnow, C Mackay, J Sprent,
C Vinuesa, F Mackay, R Brink, S Tangye, M Cook
Project title: Molecular and Cellular Basis of
Inflammatory and Immunodeficiency Diseases
Recipients: C Vinuesa, M Cook, D Fulcher,
S Alexander, A Kitching, A Enders, R Casellas, M Field,
K Schwarz, T Andrews
Funding source: NHMRC Centre for Research
Excellence 2014–2018, Centre for Personalised
Immunology
Recipients: M Cook, D Tscharke, D Fulcher
Project title: Genomic Medicine for Human
Immune Deficiency
Recipient: M Cook
Funding source: Perpetual Fund 2013
Project title: Flow Cytometry for Diagnosis of
Primary Immune Deficiency
Recipients: J D’Rozario, P Crispin, L Coupland,
M Cook, C Parish
Fund Major Project Grant 2013
Project title: Auto-Immune Cytopenias: Mechanisms,
Novel Treatment Avenues and DNA Analysis
Recipients: D Taupin, M Cook
Fund Small Project Grant 2014
Phenotyping in Families with Serrated Polyposis
95
Trauma and Orthopaedic Research Unit
The Trauma and
Orthopaedic Research
Unit (TORU) functions
as the academic unit of
Orthopaedics in Canberra.
Under the direction of
Professor Paul Smith the
unit comprises a laboratory
and a clinical arm based
at the Canberra Hospital
and the John Curtin School
of Medical Research. By
working together we aim to
investigate and innovate in
the field of musculoskeletal
injury and disease as it
pertains to the medical
specialty of Orthopaedics.
We are affiliated with the
ANU and engage closely
with the Canberra Orthopaedic surgeons, playing
a major role in the organisation of their annual
scientific meeting locally and regularly presenting
at the National meeting. Our current projects
are many and varied but broadly include the
investigation of novel mechanisms for promoting
bone repair in the presence of disease; the
development of biomarkers for rheumatoid
arthritis; the development of advanced materials
for fracture repair and arthroplasty; advanced
mathematical modelling of biological systems;
arthroplasty and trauma database development;
development of imaging technologies for kinematic
analysis and clinical guidance; and the evaluation
of trauma, arthroplasty and fracture fixation
outcomes. We collaborate with a number of
institutions and derive significant expertise in the
field of engineering, anatomy, materials science,
physiotherapy and image processing as a result.
We are supported for the most part by industry
engagement as well as by other competitive grants.
Staff
Professor Paul Smith, Director Trauma and
Orthopaedics Unit
Associate Professor Rachel Li, Laboratory Head,
John Curtin School of Medical Research; Adjunct
Associate Professor, Faculty of Health, University
of Canberra
Dr Diana Perriman, Clinical Research Coordinator
Mr Joe Lynch, Senior Research Officer
Mrs Victoria Wang, Database and Application
Architect
Dr Mona Singhal, Research Officer
Students
Ms Corinne Coulter, MPhil, Australian National
University
Supervisors: Professor Paul Smith, Associate
Professor Jennie Scarvell
Mr Ben Serpell, PhD, Australian National University
Supervisors: Professor Paul Smith, Associate Professor
Jennie Scarvell, Associate Professor Nick Ball
Dr Sumedha Amarasekara, MPhil, Australian
National University
Supervisors: Professor Paul Smith, Dr Diana Perriman
Mr Song Chen, PhD, Australian National University
Supervisors: Associate Professor Rachel Li,
Professor Paul Smith, Professor Xinhua Qin
96
Dr Claire Bolton, MPhil, Australian National University
Supervisors: Professor Paul Smith, Dr Diana Perriman
Dr David Owen, MPhil, Australian National University
Supervisors: Professor Paul Smith, Dr Chris Roberts,
Dr Diana Perriman
Mr Obinna Ihulsior, PhD, University of New South Wales
Supervisors: Dr Krishna Shankar, Mr Alan Fien,
Professor Paul Smith
Dr Mitchell Kingston, MPhil, Australian National
University
Supervisors: Professor Paul Smith, Dr Alex Webb,
Dr Diana Perriman
Mrs Olympia John, PhD, Australian National University
Mr Andrew Griffin, PhD, Australian National University
Supervisors: Professor Paul Smith, Dr Diana
Perriman
Mrs Catherine McMaster, PhD, University of Canberra
Supervisors: Associate Professor Jennie Scarvell,
Professor Paul Smith, Dr Diana Perriman
Ms Suhyun Lee, PhD, Australian National University
Supervisor: Associate Professor Rachel Li
Mr Weiqing Chen, PhD, Griffith University
Supervisors: Professor Paul Smith,
Associate Professor Rachel Li
Dr Maoyuan Xin, PhD, Shandong University
Supervisor: Associate Professor Rachel Li
Dr Partha Palit, Postdoctoral Fellow, Australian
National University
Martin Bowell, Dr David Lin, Professor Paul Smith
Collaborators
Associate Professor Jennie Scarvell, University of
Canberra
Associate Professor Mark Pickering, University of
New South Wales
Dr Alex Webb, Australian National University
Dr Sean O’Byrne, University of New South Wales
Associate Professor Girija Chetty, University of
Canberra
Associate Professor Krishna Shankar, University of
New South Wales
Dr Damian Smith, OrthoACT
Dr Al Burns, OrthoACT
Professor Chris Parish, Australian National University
Professor Nicholas Birbilis, Monash University
Professor Xinhua Qin, Australian National University
Mr Winston Piddington, ACT Health
Graduations
Ms Suhyun Lee, PhD, Australian National University
Visitors
Dr Shyam Rajagopalan, Arthroplasty Fellow with
Dr Donghai Zhang, Visiting doctor with Associate
Professor Rachel Li
Research projects
Project title: PICKLeS Study – A Prospective
Imaging study of Cruciate retaining, Substituting
and Rotating Platform Knee Replacement and
Osteoarthritis and Healthy Aging
Principal investigator: J Scarvell
Funding source: Biomet
97
Project title: The Outcomes and Kinematics
after Arthroscopic Repair for Femora-Acetabular
Impingement (FAI) Study
Principal investigator: A Burns
Funding source: TORU
Project title: Characterising Whiplash Injury using
MRI
Principal investigator: A Webb
Funding source TORU
Project title: Carbon Nano-Tubule Knee Bearing
Sensors
Principal investigator: S O’Byrne
Funding source: ACT Health; UNSW@ADFA;
TORU
Project title: Hip Prosthesis Trunnion Modelling
Principal investigator: K Shankar
Funding source: UNSW PhD funding
Project title: Short, Medium and Long Term
Survivorship of Attune™ Primary Total Knee
Prostheses
Principal investigator: P Smith
Funding source: SynthesDepuy
Project title: Controlling Initial Biodegradation
of Magnesium for Future Bioactive Orthopaedic
Implants
Principal investigator: R Li
Funding source: Victorian State Government for
the establishment of the Victorian Facility for Light
Metals Surface Technology; ARC-LP Grant (Centre
of Excellence for Design in Light Metals, at Monash
University); MRC Career Development Award
Project title: Mathematical Application in Biological
System: Bioinformatics Approach for Establishing an
Osteo-Network
Funding source: CSC PhD Scholarship
Project title: Structure and Activity Relationship
Study of Amaryllidaceae Alkaloids and Discovery of
Novel Leads for Anti-Inflammatory Drug Design
Funding source: Endeavour Scholarship of Australian
Department of Education
Project title: MicroRNAs and RNA Sequencing in
Osteolysis of Revision Hip Replacement
Funding source: Global Orthopaedics
Project title: Interaction of Bone Cells on the
TNTZ Alloys with Novel Biocompatible Coatings
Funding source: ARC-LP Grant (Centre of
Excellence for Design in Light Metals, at Monash
University); MRC Career Development Award
Project title: Heparanase – A Potential Predictive
Marker in Rheumatoid Arthritis
Funding source: Global Orthopaedics; Canberra
Hospital Private Practice Fund; ANU PhD
Scholarship
Project title: Heparanase Stimulates Human
Osteoblasts via Regulation of Osteogenic Genes
Funding source: Australian Orthopaedic Association
Research Found (AOA RF); NHMRC PhD
Scholarship
Project title: A Mathematical Model for Prediction
of Intramedullary Pressure Trend during Reaming
Funding source: AOA RF; CSC PhD Scholarship
Project title: A Cost Analysis of Infection in
Arthroplasty
Principal investigator: J Truong
Project title: The Affect of Intra-Articular
Tranexamic Acid on Outcomes after Knee
Replacement
Principal investigator: Z Avakian
Project title: Arterial Supply of the Lateral Hip
Funding source: TORU; Canberra Hospital Private
Practice Fund
Project title: Do Volar Plates lead to the Best
Outcome in Patients with Distal Radius Fractures?
Principal investigator: H Pickup
Project title: Non-Invasive Measurement of Pelvic
Tilt
Principal investigator: M Lim
Project title: The Reliability with which
Orthopaedic Registrars Classify Pelvic Fractures
Principal investigator: J Au
Funding source: TORU; Canberra Hospital Private
Practice Fund
Project title: Ten Year Review of Periprosthetic
Fractures of the Hip
Principal investigator: S Amerasekara
Project title: A Prospective Multicentre NonRandomised Clinical Outcomes Study of the R3
Acetabular System in Patients with Degenerative
Hip Disease
Funding source: Smith and Nephew
98
Project title: Rehabilitation after Elective Total Hip
Replacement
Principal investigator: C Coulter
Project title: Are Nails Superior to Plates for Fixing
Distal Tibial Fractures
Principal investigator: A Moaaz
Project title: Outcomes after Pelvic Discontinuity
Repair
Project title: Validating Hip Registration
Principal investigator: T Ward
Project title: The Fracture Outcomes Project
Funding source: Synthes; TORU
Project title: Canberra Arthroplasty Outcomes
project
Funding source: TORU; OrthoACT
Project title: Effect of Dementia after Fractured
Neck of Femur
Principal investigator: J Scarvell
Funding source: University of Canberra
Project title: Musculoskeletal Injuries in Kayak
Paddlers
Principal investigator: A Griffin
Project title: Wrist Arthrodesis Study
Principal investigator: D Owen
Project title: Leg Stiffness Kinematics
Principal investigator: B Serpell
Funding source: TORU/UC
Grants
Recipient: Strategic Opportunities Fund
Project title: Thin-Film Carbon Nanotube Load
Sensors for Application to Community Health and
Sport
Recipient: Dr Mitali Fadia
Fund
Project title: The Arterial Anatomy of the Gluteal
Tendons: a comparison of CT, microCT and
Histology
99
Recipient: S Chen
Funding source: CSC (Chinese Scholarship Council)
PhD Scholarship Grant
Project title: Bioinformatics Approach for
Establishing an Osteo-Network
Recipient: R Li
Funding source: Partnership Fund, People’s Hospital
of Changle County
Project title: Research into Healthy Bone
Recipient: P Palit
Funding source: Australian Government
Department of Education-Endeavour Research
Fellowship
Project title: Structure and Activity Relationship
Study of Amaryllidaceae Alkaloids and Discovery of
Novel Leads for Anti-Inflammatory Drug Design
Recipient: O John
Funding source: ANU Postgraduate Scholarship
Grant
Project title: Heparanase as a Biomarker in
Rheumatoid Arthritis
100
101
Publications
102
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Abdel-Latif ME, Kecskes Z and Bajuk B. (2013) Actuarial
day-by-day survival rates of preterm infants admitted
to neonatal intensive care in New South Wales and
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infants born to drug-using mothers: a state-wide
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Abdullah M PM, Scarvell J, Ward T, Smith PAbdullah M,
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analysis of human joints. Phys Med Biol 58: 4679-4702.
Ahmad KE, McColl DC, Duncan M, et al. (2013)
Neurological picture: bilateral optic neuropathy
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Aidara-Kane A, Andremont A and Collignon P. (2013)
Antimicrobial resistance in the food chain and the
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Akter M LA, Pickering MR, Scarvell JM, Smith PN. (2013)
Robust initialisation for single-plane 3D CT to 2D
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& Visualization.
Alam R KK, Tymms K, Raj A, Perera C, Swaminathan
A, Chung A and El-Haddad C. (2014) Profile of
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erythematosus (DLE) in patients receiving biologic
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R, Guduguntla M, Lueck C. (2013) The prevalence,
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C G. (2013) The drama of zoonoses: David Quammen’s
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C P. (2013) Remote Telephone Interpretation in Medical
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2013 & 2014

ACT Health Research Review 2013-2014

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