annual report 2012 - High Impact Research

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annual report 2012 - High Impact Research
ANNUAL REPORT 2012
HIGH IMPACT RESEARCH GRANT
HIGH IMPACT RESEARCH GRANT
ANNUAL
REPORT
2012
Secretariat, High Impact Research Grant
Level 1, High Impact Research Building
University of Malaya, 50603 Kuala Lumpur
www.hir.um.edu.my / [email protected]
2
High Impact Research Annual Report 2012
High Impact Research Annual Report 2012
Message from Chairman
7
HIR Committees
•
Central and Faculty
8
HIR Secretariat
•
Faculty
11
•
Central
12
HIR Advisory Council
13
HIR Background
16
Summary of Projects
16
International Collaborators
24
List of Publications HIR MoHE 2012
34
List of Presentations HIR MoHE 2012
56
List of Successful Applicants (cycle 2012)
•
HIR 2 years
74
•
HIR-MoHE 4 years
75
Research Proposals (cycle 2012)
•
HIR 2 years
78
•
HIR-MoHE (Medicine)
91
•
HIR-MoHE (Engineering)
98
•
HIR-MoHE (Dentistry)
125
•
HIR-MoHE (Computer Science & Information Technology)
141
•
HIR-MoHE (Chancellory)
147
UM HIR Publication Highlights 2012
150
UM HIR Special Features 2012
154
HIR Activity Highlights
160
University of Malaya Central High Impact Research (HIR) Core
Research Facilities
172
Financial Statement
178
HIR Faculty
179
Contact person of HIR Secretariat
181
Photo Gallery
182
CONTENT
3
4
High Impact Research Annual Report 2012
MESSAGE FROM CHAIRMAN
HIR COMMITTEES
•
•
Central
Faculty
HIR SECRETARIAT
•
•
Faculties
Central
HIR ADVISORY COUNCIL
6
High Impact Research Annual Report 2012
High Impact Research Annual Report 2012
7
“This has undoubtedly began to make an impact in the ranking scores of UM
under the QS World University Ranking, lifting UM from 167 in 2011 to 156 in
2012.”
Professor Tan Sri Ghauth Jasmon
This year, the HIR programme in UM has undergone a phase of consolidation
and started to make significant progress. It continues to garner attention, both
locally and overseas, with many new international collaborators from world-class
universities and institutions joining in our research efforts. We have appointed Dr.
Wong Chi-Huey, a world-renowned organic chemist and President of Academia
Sinica, Taiwan, as our UM Distinguished Fellow and he also serves as a member
of the UM HIR Advisory Council. President Wong has agreed to support joint
research between Academia Sinica and UM, thus enhancing the already excellent
research collaboration between UM and Taiwan universities and institutions.
This year also sees the initiation of 53 new projects funded under the special
HIR allocation provided by the Ministry of Higher Education (MOHE) Malaysia.
“As Chairman of the HIR Committee, I am thrilled with the significant
progress that has taken place so far. Clearly the coming year will see greater
achievements by HIR as many of the projects will begin to bear results and we
can expect them to bear a bountiful harvest.”
This makes it a total of 128 MoHE funded projects amounting to RM425 million
for the period ending December 2012. The balance of RM165 million out of the total
MoHE allocation of RM590 million will be used to fund new projects in 2013.
October 6 was a red letter day for HIR when renovation to Level 1 of
the HIR Building was completed after 5 months. Many new equipment have
now been moved in and commis-sioned, and training courses in the use of
high-end equipment are being conducted. The pride of this new place was
the commissioning of two multi-million ringgit instruments for next generation
sequencing, Illumina HiSeq NGS and PacBio SMRT, along with about 20 other
high-end instruments.
Last year also marked the first anniversary of HIR MoHE. Although still in its
infancy, having commenced in August 2011, HIR has already generated more than
400 Tier 1 ISI-indexed publications. Some significant publications have appeared
in such top journals as Nature Genetics, Nature Medicine and Lancet. This has
undoubtedly began to make an impact in the ranking scores of UM under the QS
World University Ranking, lifting UM from 167 in 2011 to 156 in 2012. It is also
noted that among the 5 research universities in the country, UM continues to build
a bigger lead among the pack in terms of ISI/WoS publications, achieving 1991
ISI publications in 2012 as compared to 1,500 for the second ranked university.
The HIR Committee lost the service of Prof Ishak Abd Razak when he went on
retirement. In his place, we have appointed Prof Rofina Yasmin Othman from the
Institute of Biological Sciences. Prof. Rofina Yasmin focuses her research interest
in utilizing modern biotechnolo-gy strategies to tackle fundamental problems
in agriculture and runs an active research group in the Centre for Research in
Biotechnology for Agriculture in UM. She has just returned to the university
following a 3 years’ secondment to the Biotechnology Division, Ministry of Science,
Technology and Innovation Malaysia.
As Chairman of the HIR Committee, I am thrilled with the significant progress
that has taken place so far. Clearly the coming year will see greater achievements
by HIR as many of the projects will begin to bear results and we can expect them
to bear a bountiful harvest. How-ever, we must not lose sight of our principal
goal of ultimately making UM rise into the world’s top 100 university through High
Impact Research.
Best personal regards
GHAUTH JASMON
31st December 2012
MESSAGE FROM
DR. GHAUTH JASMON
Chairman of HIR Committee
8
High Impact Research Annual Report 2012
HIR COMMITTEE
HIR COMMITTEE CENTRAL
From left to right
Emeritus Professor Dr. Yong Hoi Sen, Professor Tan Sri Ghauth Jasmon (Chairman), Professor Dr. Mohd Ali Hashim,
Professor Dr. Rofina Yasmin Othman, Professor Dr. Mohd Amin Jalaludin, Emeritus Professor Dr. Lam Sai Kit, *Not in Picture : Puan Haliza Harun
FACULTY OF MEDICINE
From left to right
Professor Dr. Amru Nasrulhaq Boyce, Professor Dr. Mohd Amin Jalaludin, Professor Dr. Adeeba Kamarulzaman
(Chairman), Professor Dr. Goh Khean Lee, Professor Dr. Tunku Kamarul Zaman Tunku Zainol Abidin
High Impact Research Annual Report 2012
FACULTY OF ENGINEERING
From left to right
Professor Dr. Nik Meriam Nik Sulaiman, Associate Professor Dr. Faisal Rafiq Mahamd Adikan, Professor Dr. Masjuki Haji Hassan, Puan Mariam Ali
FACULTY OF SCIENCE
From left to right
Professor Dr. Chong Ving Ching, Professor Dr. Mohd Sofian Azirun (Chairman), Associate Professor Dr. Sithi V.
Muniandy, Emeritus Professor Dr. Lam Sai Kit, Professor Dr. Mohd Ali Hashim
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10
High Impact Research Annual Report 2012
FACULTY OF DENTISTRY
From left to right
Associate Professor Dr. Noor Hayaty Abu Kasim, Professor Dr. Rosnah Mohd. Zain (Chairman), Professor Dr. Edward Tiekink, Professor Dr. Lui Joo Loon
FACULTY OF COMPUTER SCIENCES & INFORMATION TECHNOLOGY
From left to right
Professor Dr. Siti Salwah Salim (Chairman), Professor Dr. Lam Sai Kit, Emeritus Pr Professor Dr. Masjuki Haji Hassan,
Professor Dr. Wan Ahmad Tajuddin Wan Abdullah, Associate Professor Dr. Abdullah Ghani, Professor Dr. Ong Seng Huat
Nur Fazlin Mahfodz, Azizah Ahmad, Norshida Abdul Manan, Anis Yusnida Zakaria, Nabilah Ahmad, Nur Syafiqah Abd Malek, Norshahidayu Ali, Siti Zawahir Zubir, Mariam Ali, Lim Moo Eng,
Sarina Ramli, [email protected] Noriah Zainal Abidin, Mariah Mansor
From left to right (front)
Nur Syahrinar Anuar, Siti Fatimah Zahra Mohd Anuar, Amirul Asraf Mohd Jurami, Mohd Faiz Ibrahim, Arif Fakhri Johari, Norsaidin Mahusin, Azbullah Che Ibrahim, Muhammad Khlaid Hashim,
Alsaddam Suhaimi, Muhamad Afiq Zaini Alamar, Hamizah Husain, Ain Valerie Cassera Rapoi
From left to right (back)
HIR SECRETARIAT (FACULTIES)
High Impact Research Annual Report 2012
11
12
High Impact Research Annual Report 2012
SECRETARIAT HIR CENTRAL
From left to right (back)
Alsaddam Suhaimi, Arif Fakhri Johari, Azbullah Che Ibrahim, Lim Moo Eng
From left to right (front)
Nabilah Ahmad, Ain Valerie Cassera Rapoi, Norshahidayu Ali, Siti Zawahir Zubir, Sarina Ramli, Hamizah Husain, Azizah Ahmad
High Impact Research Annual Report 2012
UM HIR ADVISORY COUNCIL
To ensure the success of HIR, the Chairman has appointed several distinguished scientists as-members of the UM HIR
Advisory Council. Council members advise the university in matters related to research priority, as well as facilitating
joint research between their own institutions and the University of Malaya.
To date, three UM Nobel Fellows and one Distinguished Fellow have been appointed and the brief profile of each
member is provided.
Nobel Fellow Barry Marshall (Nobel Prize in Physiology or
Medicine, 2005)
Prof. Barry Marshall is Professor of Clinical Microbiology at the University of Western
Australia. His work in proving that the bacterium Helicobacter pylori is the cause of
most peptic ulcers earned him and his long-term collaborator, Robin Warren, the
2005 Nobel Prize in Physiology. In honour of Prof. Marshall winning the Nobel Prize,
UWA set up The Marshall Centre in 2007 to perform world-class infectious diseases
research and disease surveillance.
Nobel Fellow Ryoji Noyori (Nobel Prize in Chemistry, 2001)
Prof. Ryoji Noyori is President of RIKEN, one of Japan’s largest research
organizations with more than 3,000 scientists. He is also Professor in the
Department of Chemistry and Research Center for Materials Science at Nagoya
University. He shared the 2001 Nobel Prize in Chemistry with William S. Knowles for
the study of chirally catalyzed hydrogenations.
Nobel Fellow David Baltimore
(Nobel Prize in Physiology or Medicine, 1975)
Prof. David Baltimore is currently the Robert A. Millikan Professor of Biology at the
California Institute of Technology. In 1975, at the age of 37, he shared the Nobel
Prize in Physiology or Medicine with Howard Temin and Renato Dulbecco for their
discoveries concerning the interaction between tumour viruses and the genetic
material of the cell.
Distinguished Fellow Rita Colwell
Prof. Rita Colwell is Distinguished University Professor at the University of Maryland
at College Park and at Johns Hopkins University Bloomberg School of Public
Health, USA. She is currently US President Science Envoy to the Asia Pacific.
Her research interests focus on global infectious diseases and she is currently
developing an international network to address emerging infectious diseases and
water issues.
Distinguished Fellow Wong Chi-Huey
Professor Wong Chi-Huey, President of Academia Sinica, Taiwan, is the holder
of many international appointments and sits on the editorial boards of Editorial
Advisory Board member for the Journal of American Chemical Society, Angewandte
Chemie, Advanced Synthesis and Catalysis, and Current Opinion in Chemical
Biology. He is also a member of Board of Scientific Governors of the Scripps
Research Institute, the Steering Committee of the Lilly TB Drug Discovery Initiative,
and the Chief Science Advisor of the Ministry of Science, Taiwan.
13
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High Impact Research Annual Report 2012
HIR BACKGROUND
SUMMARY OF PROJECTS 2012
INTERNATIONAL COLLABORATORS
16
High Impact Research Annual Report 2012
HIR BACKGROUND
The high impact research grants from the University
of Malaya are to fund projects which will result in
publication of manuscripts in Tier 1 ISI/Web of Science
journals. As such, the emphasis is on fundamental
research which will lead to the generation of new
knowledge rather than on the development of new
products or patents. It is also aimed at generating more
research capa-bilities and expertise within the university
and this may result from collaboration with overseas
ivy-league universities.
These grants are handled differently from all existing
grants and are administered under the Chancellery. The
Vice-Chancellor is the Chairman of the High Impact
Research Committee which will evaluate the projects,
decide on its suitability for funding and monitor their
progress.
Recognizing the importance of UM as the premier
research institution in the country, the gov-ernment
made the bold decision to provide additional research
funding to UM, with the objective of having at least one
research university in the country breaking into the top
100 world ranked universities by 2015. In August 2011,
the Ministry of Higher Education (MoHE) injected RM590
million into the UM-MoHE HIR programme.
The infusion of MoHE’s additional research fund
provided the opportunity for researchers to undertake
more ambitious research over a longer period of time.
Thus, the original Chancellory HIR programme, funded
modestly using internal funds, becomes less attractive
for seasoned researchers. Nevertheless, it is felt that it
should not be dropped completely as it can still serve a
role for projects which are more focussed and targeted
to be completed within 2 years.
The Central (Chancellory) HIR Committee, chaired
by Tan Sri VC, decided that in 2012, there will be
only 2 instead of 4 cycles. The target set are still
Tier 1 publications with the cost-target of RM60,000
per publication. The maximum amount of funding
is RM500,000 for 2 years and lecturers who are not
receiving MoHE funding will be given preference.
SUMMARY OF PROJECTS 2012
PROJECTS BY YEAR (HIR-MoHE)
BUDGET (OVERALL)
No
PTj
Year 2012
(RM)
Year 2013
(RM)
Year 2014
(RM)
Year 2015
(RM)
Overall
No of
Project
1
MEDICINE
15,111,000
1,820,000
2
ENGINEERING
27,341,280
16,270,020
1,143,000
603,800
18,677,800
5
12,802,900
8,693,920
65,108,120
27
3
SCIENCE
0
0
0
0
0
0
4
DENTAL
6,279,930
3,456,729
2,873,206
2,482,486
15,092,351
13
5
COMPUTER
SCIENCE
1,218,500
940,100
772,100
270,500
3,201,200
6
6
CHANCELLORY
3,171,750
2,902,500
177,000
38,000
6,289,250
2
Total Per Year :
53,122,460
25,389,349
17,768,206
12,088,706
108,368,721
53
Year 2015
(RM)
Overall
(Equipment)
Overall
(Budget for
5 years)
Percentage %
(Overall for 5
years / Overal
Equipmments)
BUDGET (EQUIPMENT)
No
PTj
Year 2012
(RM)
Year 2013
(RM)
Year 2014
(RM)
1
MEDICINE
11,300,000
0
0
0
11,300,000
18,677,800
60.5
2
ENGINEERING
15,727,930
4,667,000
1,920,000
496,000
22,810,930
65,108,120
35.0
3
SCIENCE
0
0
0
0
0
0
0
4
DENTAL
2,871,000
20,000
15,000
0
2,906,000
15,092,351
19.3
5
COMPUTER
SCIENCE
330,600
11,000
0
0
341,600
3,201,200
10.7
6
CHANCELLORY
1,892,000
1,680,000
15,000
0
3,587,000
6,289,250
57.0
Total Per Year:
32,121,530
6,378,000
1,950,000
496,000
40,945,530
108,368,721
37.8
High Impact Research Annual Report 2012
BUDGET (OPEX)
No
PTj
Year 2012
(RM)
Year 2013
(RM)
Year 2014
(RM)
Year 2015
(RM)
Overall
(Opex)
Overall
(Budget for
5 years)
Percentage %
(Overall for 5
years / Overal
Opex)
1
MEDICINE
3,811,000
1,820,000
1,143,000
603,800
7,377,800
18,677,800
39.5
2
ENGINEERING
11,613,350
11,603,020
10,882,900
8,197,920
42,297,190
65,108,120
65.0
3
SCIENCE
0
0
0
0
0
-
0
4
DENTAL
3,408,930
3,436,729
2,858,206
2,482,486
12,186,351
15,092,351
80.7
5
COMPUTER
SCIENCE
887,900
929,100
772,100
270,500
2,859,600
3,201,200
89.3
6
CHANCELLORY
1,279,750
1,222,500
162,000
38,000
2,702,250
6,289,250
43.0
Total Per Year :
21,000,930
6,378,000
1,950,000
496,000
67,423,191
108,368,721
62.2
Tier 1 ISI
Bright
Sparks
Academic
Icon
Patent
KPI
PTj
MEDICINE
59
6
0
0
ENGINEERING
594
69
27
64
SCIENCE
0
0
0
0
DENTAL
94
1
1
3
COMPUTER
SCIENCE
28
1
1
2
CHANCELLORY
31
0
0
5
Total KPI :
806
77
29
74
PROJECTS BY FIELD OF RESEARCH
BUDGET (OVERALL)
No
PTj
1
MEDICINE
2
ENGINEERING
3
Overall
No of
Project
339,000
5
3,190,000
27
SCIENCE
0
0
4
DENTAL
5,927,125
13
5
COMPUTER
SCIENCE
349,000
6
6
CHANCELLORY
5,190,000
2
Total Per Year :
14,995,125
53
17
High Impact Research Annual Report 2012
HIR PUBLICATIONS IN ISI JOURNALS (HIR MoHE PROJECT)
MoHE HIR PUBLICATIONS (2011 & 2012)
140MoHE HIR PUBLICATIONS (2011 & 2012)
NO OFNO
PUBLICATIONS
OF PUBLICATIONS
120
140
100
120
80
100
60
80
40
60
20
40
200
MEDICINE
0
ENGINEERING
MEDICINE
SCIENCE
ENGINEERING
DENTAL
SCIENCE
COMPUTER SCIENCE
DENTAL
CHANCELLORY
COMPUTER SCIENCE
CHANCELLORY
Tier 1
Tier 2
Tier 3
Tier 4
70
Tier 1
127
70
97
127
9
97
30
9
108
20
Tier 2
16
20
34
16
12
Tier 3
5
12
16
5
12
Tier 4
6
12
11
6
34
16
11
16
8
24
108
16
8
24
30
HIR MoHE PUBLICATIONS (2011)
HIRMoHE
MoHEPUBLICATIONS
PUBLICATIONS(2011)
(2011)
HIR
MoHE HIR PUBLICATIONS 2011
30
MoHE HIR PUBLICATIONS 2011
30
25
NO OF NO
PUBLICATIONS
OF PUBLICATIONS
18
25
20
20
15
15
10
105
50
Tier 1
Tier 2
Tier 3
Tier 4
20
Tier
28 1
11
Tier
4 2
4
Tier
0 3
20
24
28
1
11
10
4
44
0
6
Tier
4 4
36
24
10
4
3
DENTAL
CHANCELLORY
COMPUTER SCIENCE
1
19
6
3
15
CHANCELLORY
19
6
3
15
MEDICINE
ENGINEERING
MEDICINE
SCIENCE
0
ENGINEERING
DENTAL
SCIENCE
COMPUTER SCIENCE
4
High Impact Research Annual Report 2012
MoHE
PUBLICATIONS
(2012)
HIRHIR
MoHE
PUBLICATIONS
(2012)
HIR MoHE PUBLICATIONS (2012)
120
MoHE HIR PUBLICATIONS 2012
MoHE HIR PUBLICATIONS 2012
NO OFNO
PUBLICATIONS
OF PUBLICATIONS
120
100
MEDICINE
ENGINEERING
MEDICINE
SCIENCE
ENGINEERING
DENTAL
100
80
80
60
60
40
40
20
200
0
SCIENCE
COMPUTER SCIENCE
DENTAL
CHANCELLORY
COMPUTER SCIENCE
Tier 1
Tier 2
Tier 3
Tier 4
50
Tier
991
9
Tier
12 2
8
Tier
15 3
6
Tier
2 4
86
73
30
889
24
12
8
10
5
9
50
73
99
8
9
24
12
30
8
12
15
2
89
5
HIR CHANCELLORY
PUBLICATIONS IN ISI JOURNALS
(HIR 210
YEARS PROJECT)
9
HIR PUBLICATIONS IN ISI JOURNALS (HIR 2 YEARS PROJECT)
HIR-CHANCELLORY
CYCLE
HIR
PUBLICATIONS INPUBLICATIONS
ISI JOURNALSBY
(HIR
2 YEARS PROJECT)
2010 PROJECT
HIR-CHANCELLORY PUBLICATIONS BY CYCLE
HIR-CHANCELLORY
PUBLICATIONS BY CYCLE
2010
PROJECT
2010 PROJECT HIR-CHANCELLORY PROJECTS 2010
NO OF PUBLICATIONS
NO OF PUBLICATIONS
50
45
50
40
45
35
40
30
35
25
30
20
25
15
20
10
155
100
5
2010
0
2011
TOTAL PUBLICATIONS
HIR-CHANCELLORY
PROJECTS 2010
TOTAL PUBLICATIONS
Tier 1
Tier 2
6
8
Tier 3
Tier 4
Tier7 2
13
8
2 3
Tier
2
3 4
Tier
1
2012
2010
151
Tier
646
2011
15
7
2
3
2012
46
13
2
1
19
PUBLICATIONS
NONO
OFOF
PUBLICATIONS
High Impact Research Annual Report 2012
20
20
18
18
16
16
14
14
12
12
10
10
8
8
6
6
4
4
2
2
0
0
2010
2010
2011
2011
2012
2012
16
16
HIR-CHANCELLORY PUBLICATIONS CYCLE 1
HIR-CHANCELLORY PUBLICATIONS CYCLE 1
Tier 1
Tier 1
Tier 2
Tier 2
1
1
19
19
4
4
Tier 3
Tier 3
Tier 4
Tier 4
HIR-CHANCELLORY
HIR-CHANCELLORY PUBLICATIONS
PUBLICATIONS CYCLE
CYCLE22
14
14
NOOFOFPUBLICATIONS
PUBLICATIONS
NO
12
12
10
10
8
8
6
6
4
4
2
2
0
0
2010
2010
2011
2011
2012
2012
Tier 1
Tier 1
2
2
3
3
15
15
Tier 2
Tier 2
6
6
Tier 3
Tier 3
Tier 4
Tier 4
1
1
1
1
4
4
HIR-CHANCELLORY PUBLICATIONS CYCLE 3
7
6
NO OF PUBLICATIONS
20
5
4
3
2
1
0
Tier 1
Tier 2
2010
4
2
2011
2
2012
6
Tier 3
HIGH
RESEARCH
REPORT 2012 16
HIGHIMPACT
IMPACT
RESEARCHANNUAL
ANNUAL
6
1 REPORT 2012 16 2
5
1
HIR-CHANCELLORY PUBLICATIONS CYCLE 4
9
Tier 4
2011
2
6
1
2012
6
5
1
2
High Impact Research Annual Report 2012
HIR-CHANCELLORY PUBLICATIONS CYCLE 4
9
8
NO OF PUBLICATIONS
7
6
5
4
3
2
1
0
Tier 1
Tier 2
Tier 3
2011
8
1
1
2012
7
3
1
Tier 4
2010
HIR PUBLICATIONS IN ISI JOURNALS (HIR 2 YEARS PROJECT)
HIR PUBLICATIONS
2011
HIRPROJECT
PUBLICATIONS IN ISI JOURNALS (HIR 2 YEARS PROJECT)
HIR-CHANCELLORY PROJECTS 2011
HIR-CHANCELLORY PROJECTS 2011
TOTAL PUBLICATIONS
18
16
NO OF PUBLICATIONS
14
12
10
HIGH IMPACT RESEARCH ANNUAL REPORT 2012 17
8
6
4
2
0
Tier 1
Tier 2
Tier 3
Tier 4
2010
2011
3
2012
17
1
HIR-CHANCELLORY PUBLICATIONS CYCLE 1
6
1
21
2011
3
High Impact Research
2012 Annual Report
17 2012
1
1
HIR-CHANCELLORY PUBLICATIONS CYCLE 1
NO OF PUBLICATIONS
6
5
4
3
2
1
0
Tier 1
Tier 2
5
1
Tier 3
Tier 4
2010
2011
2012
1
HIR-CHANCELLORY PUBLICATIONS CYCLE 2
7
NO OF PUBLICATIOS
6
5
4
HIGH IMPACT RESEARCH ANNUAL REPORT 2012 18
3
2
1
0
Tier 1
Tier 2
Tier 3
2010
2011
2
2012
6
HIR-CHANCELLORY PUBLICATIONS CYCLE 3
4.5
4
BLICATIONS
22
3.5
3
2.5
Tier 4
2011
2
2012
6
High Impact Research Annual Report 2012
HIR-CHANCELLORY PUBLICATIONS CYCLE 3
4.5
NO OF PUBLICATIONS
4
3.5
3
2.5
2
1.5
1
0.5
0
Tier 1
Tier 2
Tier 3
Tier 4
2010
2011
1
2012
4
HIR-CHANCELLORY PUBLICATIONS CYCLE 4
NO OF PUBLICATIONS
2.5
2
1.5
1
0.5
0
Tier 1
Tier 2
Tier 3
Tier 4
2010
2011
2012
2
HIGH IMPACT RESEARCH ANNUAL REPORT 2012 19
*Updated
31 December
December 2012
*Updated
asasofof31
2012
23
24
High Impact Research Annual Report 2012
INTERNATIONAL COLLABORATION
USA
Canada
UK
USA
France
Iran
UAE
Kuwait
China
Korea
Japan
Bangladesh
Thailand
Singapore
Indonesia
Australia
New Zealand
Australaisia
Europe
1.
Monash University, Australia
22. Cardiff University, United Kingdom
2.
Royal Melbourne Institute of Technology,
Melbourne, Australia
23. Imperial College, United Kingdom
3.
The Prince Charles Hospital, Brisbane, Australia
25. King’s London College, United Kingdom
4.
The University of Adelaide, Australia
26. Lancaster University, United Kingdom
5.
The University of Sydney, Australia
27. Loughborough University, United Kingdom
6.
University of Melbourne, Victoria
28. University College London United Kingdom
7.
University of New South Wales, Sydney, Australia
29. University of Birmingham, United Kingdom
8.
University of Wollongong, Australia
30. University of Cambridge, United Kingdom
Bangladesh
9.
Bangladesh University of Engineering and
Technology
Canada
10. Ryerson University, Canada
11. University of Alberta Edmonton, AB Canada
12. University of Calgary, Canada
13. University of Ottawa, Canada
24. Karolinska Institutet, Solna, Stockholm, Sweden
31. University of Edinburgh United Kingdom
32. University of Kingston, United Kingdom
33. University of Liverpool, United Kingdom
34. University of London, United Kingdom
35. University of Manchester, United Kingdom
36. University of Newcastle, United Kingdom
37. University of Oxford, United Kingdom
38. University of Plymouth United Kingdom
39. University of Southampton, United Kingdom
China
40. University of Southampton, United Kingdom
14. Chinese University of Hong Kong
41. University of Ulster, United Kingdom
15. Dalian University of Technology , China
42. Queen’s University Belfast, United Kingdom
16. National Cheng Kung University, Taiwan
17. National Taiwan University
18. Shanghai Jiao Tong University, Shanghai, China
France
43. Université Paris 1 Panthéon-Sorbonne
19. The Hong Kong Polytechnic University
Indonesia
20. University of Kansas.Taiwan
44. Gadjah Mada University, Indonesia
21. University Rd., Jinning, Kinmen, Taiwan
45. Mataram University, Indonesia
High Impact Research Annual Report 2012
Iran
New Zealand
46. Kharazmi University, Iran
65. University of Otago, New Zealand
47. Razi University, Iran 66. University of Waikato, Hamilton, New Zealand
48. University of Tehran, Iran
Singapore
Japan
67. National University of Singapore, Singapore
49. Hiroshima University, Japan
68. Singapore Immunology Network, A*Star
50. Hokkaido University, Japan
51. Keio University, Japan
52. Kumam University of Tokyo, Japan 53. Kyoto University of Education, Japan
54. Kyushu University, Japan 55. Masanobu Satake, Tohoku University, Japan
56. Multimedia University, Japan
57. Nagaoka University of Technology, Japan
58. RIKEN Center for Genomic Medicine, Japan
59. Tohoku University, Japan.
60. Tokyo Institute of Technology, Japan 61. Tokyo Metropolitan University, Japan
62. Yamaguchi University, Japan
Korea
63. Institute of Science and Technlogy, Gusongdong,Yuseong-gu, Korea
Kuwait
64. Kuwait University, Kuwait
Thailand
69. Mahidol University, Thailand
United Arab Emirates
70. University, Al Ain, United Arab Emirates
United States
71. Centers For Disease Control, Atlanta, USA.
72. Emory University, Atlanta, USA.
73. National Institutes of Health, USA
74. Origin State University, USA
75. University of California, Davis, USA
76. University of Miami
77. University of Michigan, Dearborn, USA
78. University of Pittsburgh School of Public Health,
USA
79. University of South Florida USA
80. University of Wisconsin-Madison United States
81. University School Of Medicine, USA.
82. Wayne State University, USA
25
26
High Impact Research Annual Report 2012
POSTGRADUATED STUDENTS (2011)
HIR-MoHE
(5 YEAR PROJECTS)
POSTGRADUATED
STUDENTS (2011)
HIR-MoHE (5YEAR PROJECTS)
MASTERS STUDENTS 2011
30
25
20
15
10
5
0
MEDICINE
MEDICINE
ENGINEERING
SCIENCE
Completed
Research Assistant
Local
International
11
4
COMPUTER
SCIENCE
DENTISTRY
CHANCELLORY
Ongoing
Research Assistant
Local
International
28
7
ENGINEERING
2
0
24
18
SCIENCE
3
5
16
2
DENTISTRY
6
0
4
0
COMPUTER SCIENCE
0
0
4
3
CHANCELLORY
6
8
26
1
High Impact Research Annual Report 2012
Local Students
50
45
40
35
30
25
20
15
10
5
0
International Students
Local Students
International Students
PHD STUDENTS 2011
Engineering
Science
Dental
Computer
Science
Chancellory
Medicine
Research Assistant
Ongoing
Research Assistant
Completed
Medicine
Completed
Research Assistant
Local Students
International Students
0
1
Ongoing
Research Assistant
Local Students
International Students
31
7
Engineering
0
3
18
50
Science
1
0
20
14
Dental
0
0
4
1
Computer Science
0
0
0
16
Chancellory
2
0
8
9
MoHE HIR Post Doc 2011
9
8
7
6
5
4
3
2
1
0
HIGH IMPACT RESEARCH ANNUAL REPORT 2012 25
Medicine
Engineering
Science
Dental
HIR Post Doc Local
9
2
1
3
HIR Post Doc International
2
1
1
1
Computer
Chancellory
Science
1
4
3
1
27
28
High Impact Research Annual Report 2012
POSTGRADUATED STUDENTS BY YEAR (2012)
POSTGRADUATE
STUDENTS BY YEAR (2012)
HIR-MoHE
(5 YEAR PROJECTS)
HIR-MoHE (5YEAR PROJECTS)
MASTERS STUDENTS 2012
50
45
40
35
30
25
20
15
10
5
0
MEDICINE
MEDICINE
ENGINEERING
SCIENCE
Completed
Research Assistant
Local
International
8
3
DENTISTRY COMPUTER SCIENCE CHANCELLORY
Ongoing
Research Assistant
Local
International
28
5
ENGINEERING
2
6
24
SCIENCE
9
8
40
3
DENTISTRY
0
0
2
2
49
COMPUTER SCIENCE
0
0
3
2
CHANCELLORY
14
10
40
2
High Impact Research Annual Report 2012
PHD Student
2012
Student 2012
35 35
30 30
25 25
20 20
Research Assistant
Research Assistant
Research Assistant
Research Assistant
15 15
10 10
Ongoing
Ongoing
Completed
Completed
2011
2011
Medicine
Medicine
Engineering
Engineering
Science
Science
Dental
Computer Science
Dental
Chancellory
Computer
Science
Chancellory Computer Science
Chancellory Computer Science
Dental
Dental
Completed
Completed
Research Assistant
Research Assistant
0
06
Chancellory
Science
Science
2011
2011
Medicine
Medicine
Engineering
Engineering
0
10
Ongoing
Ongoing
Research
Assistant
Research
0 Assistant
260
63
30
00
00
00
01
10
2026
1520
01
515
0 11
0
25
7 0
0
82
5 7
0
0
8
5
0
11 0
35 11
11 35
MoHE HIR Post Doc 2012
MoHE HIR Post Doc 2012
7
7 6
5
6
4
5
3
4
2
3
1
2
0
1
0
Medicine
Medicine
HIR Post Doc International
Engineering
Engineering
Science
Science
Dental
Dental
Computer
Science
Computer
Science
HIR Post Doc Local
HIR Post Doc International
Chancellory
Chancellory
Medicine
Engineering
Science
0
Medicine
0
0
Engineering
3
0
Science
2
2
Dental
0
HIR Post Doc Local
0
0
0
2
HIR Post Doc International
0
3
2
0
HIR Post Doc Local
HIR Post Doc International
HIR Post Doc Local
Dental
Computer
Science
1
Computer
0
Science
1
HIGH IMPACT RESEARCH ANNUAL REPORT 2012 28
HIGH IMPACT RESEARCH ANNUAL REPORT 2012 28
0
Chancellory
7
Chancellory
0
7
0
5 5
0
0
29
High Impact Research Annual Report 2012
POSTGRADUATED STUDENTS
HIR 2 YEARS PROJECT (2010)
POSTGRADUATE STUDENTS
HIR 2 YEARS PROJECT (2010)
MASTERS STUDENTS 2010
25
20
15
10
Research
Assistant
Project
Assistant
Research
Assistant
Ongoing
Local
International
Local
International
Local
International
Local
5
International
CYCLE 1
CYCLE 1
CYCLE 2
CYCLE 3
CYCLE 4
Project
Assistant
Completed
Completed
Project Assistant
Research Assistant
Local
International
Local
International
1
Ongoing
Project Assistant
Research Assistant
Local
International
Local
International
2
4
CYCLE 2
24
CYCLE 3
3
5
CYCLE 4
1
8
PHD STUDENTS 2010
14
12
10
8
6
4
Research
Assistant
Project
Assistant
Ongoing
CYCLE 1
Research
Assistant
Local Students
International Students
Local Students
International Students
Local Students
International Students
Local Students
2
International Students
30
CYCLE 4
CYCLE 3
Project
Assistant
Completed
Completed
Ongoing
Project Assistant
Research Assistant
Project Assistant
Research Assistant
Local
International
Local
International
Local
International
Local
International
Students
Students
Students
Students
Students
Students
Students
Students
HIGH IMPACT RESEARCH ANNUAL REPORT 2012 29
1
1
1
3
2
CYCLE 2
CYCLE 3
CYCLE 4
CYCLE 1
CYCLE 2
6
2
2
3
4
13
4
6
4
0
0
High Impact Research Annual Report 2012
HIR POST DOC 2010
4
HIR POST DOC 2010
3.5
3
2.5
2
4
1.5
3.5
1
3
0.5
2.5
2
0
1.5
1
CYCLE 2
Local
0
CYCLE 2
Local
Doc 1
International HIR Post CYCLE
Local
HIR Post Doc
1
CYCLE 1
CYCLE 2
3
CYCLE 3
4 Local
CYCLE 4
CYCLE 1
International
HIR Post Doc
0.5
CYCLE 4
CYCLE 3
HIR Post Doc
CYCLE 4
CYCLE 3
International
2
2
1
International
1
2
3
2
CYCLE 3
4
1
CYCLE 4
1
2
CYCLE 1
1
CYCLE 2
2
POSTGRADUATED
STUDENTS
POSTGRADUATE STUDENTS
HIR 2 YEARS PROJECTS (2011)
POSTGRADUATE STUDENTS
HIR 2 YEARS
HIRPROJECT
2 YEARS (2011)
PROJECTS (2011)
MASTERS STUDENTS 2011
International
Local
International
Local
International
Local
International
International
Local
International
Local
Local
International
International
MASTERS STUDENTS 2011
CYCLE 4
CYCLE 4
CYCLE 2
CYCLE 3
CYCLE 1
CYCLE 2
CYCLE 3
CYCLE 1
Research
ResearchResearch
ProjectProjectResearch
Assistant
Assistant
AssistantAssistant
Assistant
Assistant
OngoingOngoing
Research Assistant
International Research
LocalAssistant
International
International
Local 3 International
CYCLE
1
CYCLE 1 CYCLE 2
CYCLE 2 CYCLE 3
3
CYCLE 3 CYCLE 4
2
CYCLE 4
1
1
1
2
1
1
Ongoing
Ongoing Research Assistant
Project Assistant
Project
ResearchInternational
Assistant
Local Assistant
International
Local
Local7
International
Local
International
1
7 2
2 2
2
1
8
18
1
1
HIGH IMPACT RESEARCH ANNUAL REPORT 2012 31
3
3
8
7
6
5
4
3
2
1
0
8
7
6
5
4
3
2
1
0
31
PHD STUDENT 2011
High Impact Research Annual Report 2012
20
Ongoing
Research
Assistant
Project
Assistant
Ongoing
International
CYCLE 1
CYCLE 2CYCLE 1
Local
International
International
Local
International
International
Local
Project
Assistant
Local
International
International
Research
Assistant
Local
International
Local
PHD STUDENT 2011
International
32
Research
Assistant
Research
Assistant
Research Assistant
Local
International
Research Assistant
Local
International
International
CYCLE 3CYCLE 2
15
5
10
0
0
Ongoing
Project Assistant
Research Assistant
Ongoing
Local
International
Local
International
Project
Research7Assistant
4 Assistant
3
Local
44
International
Local
7
4
CYCLE 4CYCLE 3
CYCLE 4
15
5
CYCLE 1
CYCLE 2
CYCLE 3
CYCLE 4
10
CYCLE 1
CYCLE 2
CYCLE 3
CYCLE 4
20
8
8
7
International
3
7
2
2
16
16
6
6
9
9
HIR-CHANCELLORY POSTDOC
2011
HIR-CHANCELLORY
POSTDOC
2011
3
3
2
2
1
1
0
0
CYCLE 2
CYCLE 1
CYCLE 1
CYCLE 2
CYCLE 3
CYCLE CYCLE
1
4
CYCLE 2
CYCLE 1
Local
3
1
Local
1
32
1
HIR Post Doc
CYCLE 2
HIR Post Doc
CYCLE 4
CYCLE 3
CYCLE 4
CYCLE 3
International
1
3
International
1
1
0
3
CYCLE 3
1
0
CYCLE 4
2
1
*Updated as of 31 December 2012
HIGH IMPACT RESEARCH ANNUAL REPORT 2012 32
HIGH IMPACT RESEARCH ANNUAL REPORT 2012 32
LIST OF PUBLICATIONS HIR MOHE
LIST OF PRESENTATIONS HIR MOHE 2012
LIST OF SUCCESSFUL APPLICANTS 2012
34
High Impact Research Annual Report 2012
LIST OF PUBLICATIONS HIR MOHE 2012 BY FACULTY
FACULTY OF MEDICINE
1.
Lim A, Amini A, D’Orsogna LJ, Rajasuriar R,
Kramski M, Lewin SR, Purcell DF, Price P, French
MA.(2011)Antibody And B Cell Responses
May Control Circulating Lipopolysaccharide
In Patients With HIV Infection, AIDS. 2011 Jul
17;25(11):1379-83.
2.
Tan DBA, Lim A, Yong YK, Ponnampalavanar
S, Omar S, Kamarulzaman A, French MA
(2011)TLR2-Induced Cytokine Responses May
Characterize HIV-Infected Patients Experiencing
Mycobacterial Immune Restoration Disease.,
Price P. AIDS. 2011 Jul 31; 25(12): 1455-60.
3.
4.
5.
6.
Sungkanuparph S, Oyomopito R, Sirivichayakul
S, Sirisanthana T, Li PCK, Kantipong P, Lee CKC,
Kamarulzaman A, Messerschmidt L, Law MG,
Phanuphak P (2011). HIV-1 Drug Resistance
Mutations Among Antiretroviral-Naïve Hiv-1Infected Patients In Asia: Results From The
Treat Asia Studies To Evaluate ResistanceMonitoring Study.; on behalf of the TREAT Asia
Studies to Evaluate Resistance-Monitoring Study
(TASER-M). Clin Infect Dis. 2011 Apr;52(8):10531057.
Lau YL, Tan LH, Chin LC, MY Fong, Noraishah
MA, Rohela M (2011). Plasmodium Knowlesi
Re-Infection In Human. Emerging Infectious
Diseases. 17 (7): 1314-15
Yee-Ling Lau, Mun-Yik Fong, Rohela Mahmud,
Phooi-Yee Chang, Vanitha Palaeya, Fei-Wen
Cheong, Lit-Chein Chin, Claudia N Anthony,
Abdulsalam MQ Al-Mekhlafi And Yeng Chen.
(2011) Specific, Sensitive And Rapid Detection
Of Human Plasmodium Knowlesi Infection By
Loop-Mediated Isothermal Amplification (LAMP)
In Blood Samples. Malaria Journal. 10:197 Open
access
Mariappan V, Vellasamy KM, Hashim OH,
Vadivelu J. Profiling of Burkholderia cepacia
secretome at mid-logarithmic and earlystationary phases of growth. Plos One (2011); 6
(10): e26518. doi: 10.1371/journal.pone.0026518
7.
Mokhtar AS, Tay ST. Molecular detection of
Rickettsia felis, Bartonella henselae, and B.
clarridgeiae in fleas from domestic dogs and cats
in Malaysia. Am J Trop Med Hyg. 2011 85(5):931-3.
8.
Phooi Yee Chang, Mun Yik Fong, Veeranoot
Nissapatorn, Yee Ling Lau. (2011). Evaluation of
Pichia-expressed recombinant rhoptry protein
2 (ROP2) of Toxoplasma gondii towards its
application in diagnosis of toxoplasmosis..
American Journal of Tropical Medicine And
Hygiene 85(3): 485–489
9.
Sui-Ting Lee; Pooi-Fong Wong; Shiau-Chuen
Cheah; Mohd Rais Mustafa. 2011. AlphaTomatine Induces Apoptosis and Inhibits Nuclear
Factor-Kappa B Activation on Human Prostatic
Adenocarcinoma PC-3 Cell. PLoS ONE 6(4):
e18195 (ISI-Cited Publication)
10. Mohamed EHM, Tan KS,Mohd Ali J, Mohamed
Z.TT genotype of the methylenetetrahydrofolate
reductase C677T polymorphism is an important
determinant for homocysteine levels in multiethnic Malaysian ischaemic stroke patients. Ann
Acad Med Singapore 2011;40:186-191 (ISI-Cited
Publication)
11. BS Haerian, H Roslan, AA Raymond, CT Tan,
KS Lim, SZ Zulkifli, EHM Mohamed, HJ Tan
and Z Mohamed. Association of ABCB1 gene
polymorphisms and their haplotypes with
response to antiepileptic drugs: A systematic
review and meta-analysis. Pharmacogenomics
2011:12(5); 713-725. (DOI: 10.2217/PGS.10.212)
(Impact Factor = 4.398; Tier 1). (ISI-Cited
Publication)
12. EHM Mohamed, KS Tan, JM Ali, Z Mohamed.
TT genotype of the methylenetetrahydrofolate
reductase C677T polymorphism is an
important determinant for homocysteine levels
in multi-ethnic Malaysian ischaemic stroke
patients. Annals Academy of Medicine. 2011.
40(4);186-191(Impact Factor = 1.01) (ISI-Cited
Publication)
13. BS Haerian, H Roslan, AA Raymond, CT Tan,
KS Lim, SZ Zulkifli, EHM Mohamed, HJ Tan
and Z Mohamed. Lack of association of ABCB1
and PXR polymorphisms with response to
treatment in epilepsy. Seizure 2011. 20 (5): 387394. (Impact Factor = 2.233; Tier 3) (ISI-Cited
Publication)
14. BS Haerian, H Roslan, AA Raymond, CT
Tan, KS Lim, SZ Zulkifli, EHM Mohamed, HJ
Tan and Z Mohamed. Association of ABCB1
polymorphisms with response to sodium
valproate treatment in Malaysian epilepsy
patients. Epileptic Disorders 2011; 13(1): 65-75
(Impact Factor = 1.26). (ISI-Cited Publication)
15. Ching-Lee Wan, Nor Zuraida Zainal, Lay-Hoong
Lian, Zahurin Mohamed. Association of the
functional polymorphism in the Catechol-OMethyltranferase gene with schizophrenia in the
three ethnic groups of the Malaysian population.
Psychiatry Research 2011; 189(1): 67-71 (Impact
Factor = 2.373). http://dx.doi.org/10.1016/j.
psychres.2011.02.008 (ISI-Cited Publication)
16. BS Haerian, KS Lim, EHM Mohamed, HJ Tan,
CT Tan, AA Raymond, CP Wong, SW Wong,
and Z Mohamed. Lack of association between
synapsin II (SYN2) gene polymorphism and
susceptibility epilepsy: A case control study and
meta-analysis. Synapse 2011; 65(10): 1073-79.
(Impact Factor = 2.557: Tier 3 Publication). (ISICited Publication)
17. BS Haerian, KS Lim, EHM Mohamed, HJ Tan,
CT Tan, AA Raymond, CP Wong, SW Wong,
and Z Mohamed. Lack of association of
ABCB1 haplotypes on five loci with response to
High Impact Research Annual Report 2012
treatment in epilepsy. Seizure 2011; 20 (7); 546553. DOI: 10.1016/j.seizure.2011.04.003 (Impact
Factor = 2.233: Tier 3 Publication). (ISI-Cited
Publication)
18. Zain, SM; Mohamed, Z; Mahadeva, S; et al. Does
polymorphism in patatin-like phospholipase 3
gene (PNPLA3) confer risk of nonalcoholic fatty
liver disease (NAFLD) in multiethnic Malaysian
population? Drug Metabolism Reviews Volume:
43 Pages: 56-57 Published: MAY 2011 (ISI-Cited
Publication)
19. Zain, MAM; Zainal, NZ; Kanagasundram, S;
Mohamed, Z Association between PDLIM5 gene
and bipolar disorder in Malaysian population.
Drug Metabolism Reviews 2011 May. 43:57-57
(ISI-Cited Publication)
20. Mohamed, Z; Haerian, BS; Lim, KS; et al.
Association of ABCB1 polymorphisms with
response to sodium valproate in Malaysian
epilepsy patients.Drug Metabolism Reviews 2011
May. 43:80-81 (ISI-Cited Publication)
21. Kong WM, Chik Z, Ramachandra M,
Subramaniam U, Aziddin RER and Mohamed Z.
Evaluation of the Effects of Mitragyna speciosa
Alkaloid Extract on Cytochrome P450 Enzymes
Using a High Throughput Assay. Molecules 2011,
16, 7344-7356; doi:10.3390/molecules16097344
(Tier 2; Impact Factor 1.988) (ISI-Cited
Publication)
22. Zahurin Mohamed, Zuraida Zainal, Lay Hoong
Lian and Ai Chin Loke. Association Study
of Tryptophan Hydroxylase 2 and Serotonin
Transporter Genes with Major Depressive
Disorder in Malaysian Ethnic Subgroups. Clinical
Psychopharmacology and Neuroscience 2011;9
(1):40-40. (SCOPUS-Cited Publication)
23. Yamunah Devi Apalasamy, Moy Foong Ming,
Sanjay Rampal, Awang Bulgiba and Zahurin
Mohamed. Gender-Dependent Association of
a Beta2-adrenergic Gene variant With Obesity
Parameters in Malaysian Malays. Asia Pacific
Journal of Public Health. Oct 2011. (ISI-Cited
Publication)
24. Sundaram C, Shankar SK, Thong WK, PardoVillamizar CA. Pathology and diagnosis of central
nervous system infections. Pathology Research
International 2011, Article ID878263, 4 pages,
doi:10.4061/2011/878263
25. Wong, K. T., and K. C. Ong. 2011. Pathology
of acute henipavirus infection in humans and
animals. Patholog Res Int 2011:567248.
26. Nazir R, Mazhar M, Wakeel T, Akhtar MJ,
Siddique M, Nadeem M, Khan NA, Shah R.
Pyrolysis Mechanism of Trisbipyridineiron(II)
Chloride to Iron Nanoparticles. J. Therm Anal
Calorim (2011) DOI:10.1007/s10973-011-1919-5
27. Nazir R, Mazhar M, Wakeel T, Akhtar MJ,
Siddique M, Nadeem M, Khan NA, Shah R.
Pyrolysis Mechanism of Trisbipyridineiron(II)
Chloride to Iron Nanoparticles. J. Therm Anal
Calorim (2011) DOI:10.1007/s10973-011-1919-5
28. Kheng Seang Lim, Chin Hwan Lim, Chong Tin
Tan. Attitudes toward epilepsy, a systematic
review. Neurology Asia 2011; 16(4) : 269 – 280
29. Lau YL, Tan LH, Chin LC, MY Fong, Noraishah
MA, Rohela M (2011). Plasmodium Knowlesi
Re-Infection In Human. Emerging Infectious
Diseases. 17 (7): 1314-15
30. Lee, M.L., Tan, N.H., Fung, S.Y. and Shamala,
D.S. (2011). Antibacterial action of a heat-stable
form of L-amino acid oxidase isolated from king
cobra (Ophiophagus hannah) venom. Comp.
Biochem. Physiol. C. 153, 237-242.
31. Omar NA, Abdullah N, Kuppusamy UR, Abdulla
MA, Sabaratnam V. 2011. Nutritional comparison,
antioxidant activities and antiulcer potential of
Lentinus squarrosulus (Mont.) mycelia extract.
Evidence Based complementary and Alternative
Medicine.DOI: 10.1155/2011/539356
32. Rajarajeswaran J, MS Kanthimathi. 2011.
Inhibitory effects of fruit extracts on nitric
oxide-induced proliferation in MCF-7 cells. Food
Chemistry 126:956-960.
33. Ng ZX, Kuppusamy UR, Tajunisah I, Choong
KSF, Choon AAK, Chua KH. 2011. 2245G/A
polymorphism of the receptor for advanced
glycation end-products (RAGE) gene is
associated with diabetic retinopathy in the
Malaysian population. Bri J Ophthal. DOI:
10.1136/bjothalmol-2011-300658
34. Leong KH, Chung LY, Noordin MI, Onuki Y,
Morishita M, Takayama K. Lectin-functionalized
carboxymethylated kappa-carrageenan
microparticles for oral insulin delivery. Carb
Polym. 2011, 86: 555-565.
35. Leong KH, Chung LY, Noordin MI, Mohamad K,
Nishikawa M, Onuki Y, Morishita M, Takayama
K. Carboxymethylation of kappa-carrageenan
for intestinal-targeted delivery of bioactive
macromolecules. Carb Polym. 2011, 83: 15071515.
36. Gan, C.S., CW Wang, & Tan KS. (2012).
Circulatory microRNA-145 expression is
increased in cerebral ischemia, Genet. Mol.
Biol. 11 (1): 147-152. (ISI/SCOPUS Cited
Publication). [Impact factor – 0.634, ISI [email protected]
Ranking 2011,132/290, TIER II (Biochemistry &
Molecular Biology)] [Citation: ISI – 2]
37. Raja Izaham RM, Abdul Kadir MR, Abdul
Rashid AH, Hossain MG, Kamarul T. Finite
element analysis of Puddu and Tomofix plate
fixation for open wedge high tibial osteotomy.
Injury (2012) Jun;43(6):898-902. doi: 10.1016/j.
injury.2011.12.006
38. Mokhtar AS, Lim SF, Tay ST. First Molecular
Detection of Anaplasma platys and Babesia
gibsoni in Dogs in Malaysia. Accepted by
Tropical Biomedicine, 2012. Thesis Master of
Medical Science Degree (Aida Syafinaz Mokhtar)
39. Chan Y.F., Wee, K.L., Chiam, C.W., Khor, C.S.,
Chan, S.Y., Wan Nor Amalina W.M.Z., Sam, I.C.
(2012). Comparative Genetic Analysis of VP4,
VP1 and 3D Gene Regions of Enterovirus 71
and Coxsackievirus A16 Circulating in Malaysia
between 1997-2008. Tropical Biomedicine 29:
451-466.
40. Ng KP, Ngeow YF, Yew SM, Hassan H, Soo-Hoo
TS, Na SL, Chan CL, Hoh CC, Lee KW, Yee
35
36
High Impact Research Annual Report 2012
WY. 2012. Draft Genome Sequence of Daldinia
eschscholzii Isolated from Blood Culture.
Eukaryotic Cell 11(5):703-704. DOI: 10.1128/
EC.00074-12.
41. Ng KP, Yew SM, Chan CL, Soo-Hoo TS, Na SL,
Hassan H, Ngeow YF, Hoh CC, Lee KW, Yee
WY. 2012. Genome sequence of an unclassified
pleosporales species isolated from human
nasopharyngeal aspirate. Eukaryotic Cell
11(6):828. doi: 10.1128/EC.00133-12.
42. Lai S-L, Cheah S-C, Wong P-F, Noor SM,
Mustafa MR (2012) In Vitro and In Vivo AntiAngiogenic Activities of Panduratin A. PLoS ONE
7(5): e38103.
43. Aditya Arya, Shiau Chuen Cheah, Chung
Yeng Looi, Hairin Taha, Mohd. Rais Mustafa
and Mustafa Ali Mohd. The methanolic
fraction of Centratherum anthelminticum seed
downregulates pro-inflammatory cytokines,
oxidative stress, and hyperglycemia in
STZ-nicotinamide-induced type 2 diabetic
rats. Food and Chemical Toxicology . 2012
Nov;50(11):4209-20
44. Ismail Adam Arbab, Chung Yeng Looi, Ahmad
Bustamam Abdul, Foo Kit Cheah, Won Fen
Wong, Mohd Aspollah Sukari, Rasedee
Abdullah, Syam Mohan, Suvitha Syam, Aditya
Arya, Manal Mohamed Elhassan Taha, Bushra
Muharram, Mohd Rais Mustafa and Siddig
Ibrahim Abdelwahab. 2012. Dentatin induces
apoptosis in prostate cancer cells via Bcl-2,
Bcl-xL, Survivin downregulation, caspase-9,
-3/7 activation and NF-kB inhibition. EvidenceBased Complementary and Alternative Medicine.
2012;2012:856029
45. Aditya Arya, Chung Yeng Looi, Shiau Chuen
Cheah, Mohd Rais Mustafa and Mustafa Ali
Mohd. Anti-diabetic effects of Centratherum
anthelminticum seeds methanolic fraction
on pancreatic cells, β-TC6 and its alleviating
role in type 2 diabetic rats. Journal of
Ethnopharmacology. 2012 Oct 31;144(1):22-32
46. Arya A, Achoui M, Cheah SC, Abdelwahab
SI, Narrima P, Mohan S, Mustafa MR, Mohd
MA. Chloroform Fraction of Centratherum
anthelminticum (L.) Seed Inhibits Tumor
Necrosis Factor Alpha and Exhibits Pleotropic
Bioactivities: Inhibitory Role in Human Tumor
Cells. Evid Based Complement Alternat Med.
2012;2012:627256. doi: 10.1155/2012/627256.
47. Lay-Hoong Lian, Ai-Chin Loke, Nor Z Zainal,
Zahurin Mohamed. Association study of the
tryptophan hydroxylase 1 gene with major
depressive disorder in three ethnic groups of the
Malaysian population. Asian Biomedicine (2012)
(Accepted for pubication) (ISI-Cited Publication)
48. Shamsul Mohd Zain, Rosmawati Mohamed,
Sanjiv Mahadeva,Cheah Phaik Leng,Sanjay
Rampal,Roma Choudhury Basu, Zahurin
Mohamed. (2012) A multi-ethnic study of a
PNPLA3 gene variant and its association with
disease severity in non-alcoholic fatty liver
disease. Human Genetics 2012; 131(7): 114552 (Tier 1, Impact Factor 5.047). (ISI-Cited
Publication)
49. Yamunah Devi Apalasamy, Moy Foong Ming,
Sanjay Rampal, Awang Bulgiba, Zahurin
Mohamed. 2012. Genetic association study
between SNPs in FTO gene and predisposition to
obesity in Malaysian Malays. Brazilian Journal of
Medical and Biological Research 2012 (ISI-Cited
Publication)
50. Batoul Sadat Haerian, Larry Baum, Hui Jan
Tan, Patrick Kwan, Azman Ali Raymond,
Junji Saruwatari, Kazuko Nakagawa, Zahurin
Mohamed. 2012. SCN1A IVS5N+5 polymorphism
and response to sodium valproate: A multicenter
study. Pharmacogenomics 2012 (Tier 1).
13(13):1477-85. doi: 10.2217/pgs.12.127.
Accepted for publication (ISI-Cited Publication)
51. Yamunah Devi Apalasamy, Moy Foong Ming,
Sanjay Rampal, Awang Bulgiba and Zahurin
Mohamed. 2012. Association of Melanocortin-4
Receptor Gene Polymorphisms with Obesityrelated Parameters in Malaysian Malays. Annals
of Human Biology 2012 (accepted) (ISI-Cited
Publication)
52. Y.D. Apalasamy, M.F. Ming, S. Rampal, A.
Bulgiba and Z. Mohamed. 2012. Genetic
association of SNPs in the FTO gene and
predisposition to obesity in Malaysian Malays.
Braz J Med Biol Res-provisional Epub Aug
23, 2012, http://dx.doi.org/10.1590/S0100879X2012007500134 (ISI-Cited Publication)
53. Ghasemi R, Haeri A, Dargahi L, Mohamed Z,
Ahmadiani A. 2012. Insulin in the brain: Sources,
Localization and Functions. Mol Neurobiol [Epub
ahead of print] Tier 1 (ISI-Cited Publication)
54. Mohd Aizat Zain, Suffee Nusrat Jahan, Gavin
P Reynolds, Nor Zuraida Zainal, Sharmilla
Kanagasundram and Zahurin Mohamed 2012.
Peripheral PDLIM5 expression in bipolar disorder
and the effect of olanzapine administration.BMC
Medical Genetics 2012. doi: 10.1186/1471-235013-91 Journal: BMC Medical Genetics (ISI-Cited
Publication)
55. Vijayapandi Pandy, Megala Narasingam and
Zahurin Mohamed. Antipsychotic-like activity
of Noni (Morinda citrifolia Linn.) in mice. BMC
Complementary and Alternative Medicine 2012.
doi: 10.1186/1472-6882-12-186 (ISI-Cited
Publication) Tier 1
56. Shamsul Mohd Zain, Zahurin Mohamed, Sanjiv
Mahadeva, Phaik-Leng Cheah, Sanjay Rampal,II
Kin-Fah Chin, Roma Choudhury Basu, Hwa-Li
Tan, and Rosmawati Mohamed. The impact of
LEPR variants on risk of non-alcoholic fatty liver
disease and its interaction with PNPLA3 variant.
Journal of Gastroenterology and Hepatology
2012. (ISI-Cited Publication)
57. Apalasamy, Y.D., Ming, M.F., Rampal, S.,
Bulgiba, A., Mohamed, Z., 2012. Association of
melanocortin-4 receptor gene polymorphisms
with obesity-related parameters in Malaysian
Malays. Annals of human biology.DOI:10.3109/03
014460.2012.720709 (ISI-Cited Publication).
58. Wong KT, Ng KY, Ong KC, Ng WF, Shankar SK,
Mahadevan A, Radotra B, Su IJ, Lau G, Ling AE,
Chan KP, Macorelles P, Vallet S, Cardosa MJ,
Desai A, Ravi V, Nagata N, Shimizu H, Takasaki T.
High Impact Research Annual Report 2012
Enterovirus 71 encephalomyelitis and Japanese
encephalitis can be distinguished by topographic
distribution of inflammation and specific
intraneuronal detection of viral antigen and RNA.
Neuropathology and Applied Neurobiology 2012;
38: 443-453
World Congress of Neuropsychopharmacology,
Stockholm, Sweden, 3–7 June 2012.
(2012). The International Journal of
Neuropsychopharmacology, 15(SupplementS1),
1-271. doi:10.1017/S1461145712000508. (ISIcited publication).
59. Mathieu C, Guillaume V, Sabine A, Ong
KC, Wong KT, Legras-Lachuer C, Horvat B.
Lethal Nipah virus infection induces rapid
overexpression of CXCL10 in endothelial cells.
PLoS ONE 2012; 7 (2):e32157. doi:10.1371/
journal.pone.0032157
68. Fatemeh Molaei V, Maysam O, Fatimah I,
Rusdi AR, Mohamad Hussain H, Kheng Seang
L, Siew Cheok N. ( 2012). EEG analysis of
the initial methadone treatment in heroin
dependent. Medical and Biology Engineering and
Computing. Under review.
60. Mathieu C, Guilaume V, Volchkova V, Pohl C,
Jacquot F, Looi R, Wong KT, Legras Lachuer C,
Volchkov V, Lachuer J, Horvat B. Nonstructural
Nipah virus C protein regulates both the early
host proinflammatory response and viral
virulence. Journal of Virology 2012; 86: 1076610775
69. Fung, S.Y., Tan, N.H., Sim, S.M. and Aguiyi, J.C.
2012. Effect of Mucuna pruriens seed extract
pretreatment on the responses of spontaneously
beating rat atria and aortic ring to Naja spuatrix
(Javan spitting cobra) venom. Evidence-based
Complementary and Alternative Medicine. Vol
2012, ID 486390. Doi:10.1155/2012/486390.
61. Ch’ng WC, Stanbridge EJ, Wong KT, Ong
KC, Yusoff K, Shafee N. Immunization with
recombinant enterovirus 71 viral capsid protein
1 fragment stimulated antibody responses in
hamsters. Virology Journal 2012; 9:155
70. Leong, P.K., Tan, N.H., Fung, S.Y. and Sim, S.M.
(2012). Cross neutralization of Southeast Asian
cobra and krait venoms by Indian polyvalent
antivenoms. Trans Royal Soc Tropical Med.
http://dx.doi.org/10.1016/j.trstmh.2012.07.009.
(Tier-2).
62. Ploquin A, Szécsi J., Mathieu C, Guillaume V ,
Barateau V, Ong KC, Wong KT, Cosset FL, Horvat
B, Salvetti A. Protection against henipavirus
infection using recombinant AAV vector vaccines
Journal of Infectious Diseases 2012 (in press).
63. Wong KT, Tan CT. Clinical and pathological
manifestations of human henipavirus infection.
Curr Top Microbiol Immunol 2012; 359: 95-104
64. Tan, KS, HG Lee, LH Lian, Lu YS, BC
Chen, CW Wang, & Menon J. (2012).
Mitochondrial neurogastrointestinal
encephalomyopathy(MNGIE) in a Malaysian
patient with a novel mutation in thymidine
phosphorylase gene: A Case Report. Neurology
Asia 17(2) : 163 – 168. (ISI/SCOPUS Cited
Publication). [Impact Factor 0.186, ISI [email protected]
Ranking 2011,134/192, TIER III (Clinical
neurology)]
65. Kheng-Seang Lim, Cathie Wu, Wan-Yuen Choo,
Chong-Tin Tan. Development and validation of
a Public Attitudes Toward Epilepsy (PATE) scale.
Epilepsy and Behavior 2012; 24(2):207-12
66. Siti Idayu H, Rusdi AR, Muhammad Muhsin AZ,
Chong Guan N, Ahmad Hatim S, Fatimah I, Noor
Zuraini R, Rahimah AK, Muna M, Mohamad
Hussain H, Wan Azlinda Irnee WH. A study
on the effectiveness of electroacupuncture
as adjunctive treatment among methadone
maintenance therapy clients in University of
Malaysia Medical center, kuala Lumpur, Malaysia.
Abstracts from the 28th CINP World Congress
of Neuropsychopharmacology, Stockholm,
Sweden, 3–7 June 2012. (2012). The International
Journal of Neuropsychopharmacology,
15(SupplementS1), 1-271.doi:10.1017/
S1461145712000508. (ISI-cited publication).
67. Wan Azlinda Irnee WH, Siti Idayu H, Azhar
S, Muna M,Rusdi AR, Mohamad Hussain H.
Amphetamine-type stimulants use among drug
users on the street at Chow Kit Road, Kuala
Lumpur, Malaysia. Abstracts from the 28th CINP
71. R.Jayakumar, M.S. Kanthimathi. 2012. Dietary
spices protect against hydrogen peroxideinduced DNA damage and inhibit nicotineinduced cancer cell migration. Food Chemistry.
134:1580-1584
72. R Ngui, YAL Lim, KH Chua (2012). Rapid
detection and identification of human hookworm
infections through high resolution melting (HRM)
analysis. PloS One 7:e41996
73. SD Puthucheary, SM Puah, KH Chua (2012).
Molecular Characterization of Clinical Isolates of
Aeromonas Species from Malaysia. PLoS ONE
7(2):e30205
74. CH Chew, YAL Lim, PC Lee, R Mahmud and KH
Chua (2012). A hexaplex PCR detection system
for the identification of five human Plasmodium
species with internal control. Journal of Clinical
Microbiology. 12:4012-4019
75. Salem, S.D., Saif-Ali, R.,Ismail, I.S., Al-Hamodi,
Z., Poh, R. and Muniandy, S. (2012). IGF2BP2
Alternative Variants Associated with Glutamic
Acid Decarboxylase Antibodies Negative
Diabetes in Malaysian Subjects. Plos One, 7(9):
e45573. doi:10.1371/journal.pone.0045573
76. Razali N, Mat-Junit S, Abdul-Muthalib AF,
Subramaniam S, Abdul-Aziz A. Effect of
various solvents on the extration of antioxidant
phenolics from the leaves, seeds, veins and
skins of Tamarindus idica L. Food Chem. 2012
Mar;131(2):441-8.
77. Kong KW, Mat-Junit S, Aminudin N, Ismail
A, Abdul-Aziz A. Antioxidant activities and
polyphenolics from the shoots of Barrigtonia
racemosa (L.) Spreng in a polar to apolar medium
system. Food Chem. 2012 Sep;134(1):324-332.
78. Jayapalan JJ, Ng KL, Razack AH, Hashim
OH. Identification of potential complementary
serum biomarkers to differentiate prostate
cancer from benign prostatic hyperplasia using
37
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High Impact Research Annual Report 2012
gel- and lectin-based proteomics analyses.
Electrophoresis. 2012 Jul;33(12):1855-62.
79. Chong URW, Abdul-Rahman PS, Abdul-Aziz A,
Hashim OH, Mat-Junit S. Tamarindus indica
extract alters of alpha enolase, apolipoprotein
A-I, transthyretin and Rab GDP dissociation
inhibitor beta from HepG2 cells. PLoS ONE.
2012 Jun;7(6)
80. Zaki, R., Bulgiba, A., Ismail, R., & Ismail, N. A.
(2012). Statistical Methods Used to Test for
Agreement of Medical Instruments Measuring
Continuous Variables in Method Comparison
Studies: A Systematic Review. PLoS ONE, 7:
e37908.doi:10.1371/journal.pone.0037908
81. Moy FM, Ray A, Buckley B. 2012. Techniques
of monitoring blood glucose during pregnancy
for women with pre-existing diabetes (Protocol).
Cochrane Review Database of Systematic
Review, Issue 2. (ISI-Cited Publication)
82. Chu, A.H.Y., Moy, F.M., 2012. Associations of
occupational, transportation, household and
leisure-time physical activity patterns with
metabolic risk factors among middle-aged
adults in a middle-income country. Preventive
Medicine.DOI:http://dx.doi.org/10.1016/j.
ypmed.2012.12.011 (ISI-Cited Publication)
83. Noran N Hairi, Awang Bulgiba, Devi Peramalah,
Izzuna Mudla. Do older people with visual
impairment and living alone in a rural developing
country report greater difficulty in managing
stairs? Preventive Medicine (2012), http://dx.doi.
org/10.1016/j.ypmed.2012.10.016 (ISI-Cited
Publication)
84. Kamkaew A, Lim SH, Lee HB, Kiew LV, Chung
LY, Burgess K. BODIPY dyes in photodynamic
therapy. Chem Soc Rev. (2012) DOI: 10.1039/
c2cs35216h (Impact Factor 28.76)
FACULTY OF ENGINEERING
1
2
3
4
Shahbaz K., Mjalli F. S., Hashim M. A., AlNashef
I. M., Eutectic Solvents for The Removal of
Residual Palm Oil-Based Biodiesel Catalyst,
Journal of Separation and Purification
Technology. 2011, 81, pp. 216-222 (Elsevier) (Q1)
Shahbaz K., Mjalli F. S., Hashim M. A., AlNashef
I. M., Eutectic Solvents for The Removal of
Residual Palm Oil-Based Biodiesel Catalyst,
Journal of Separation and Purification
Technology. 2011, 81, pp. 216-222 (Elsevier) (Q1)
Shahbaz K., Mjalli F. S., Hashim M. A., AlNashef
I. M., Using Deep Eutectic Solvents Based on
Methyl Triphenyl Phosphunium Bromide for
the Removal of Glycerol from Palm Oil-Based
Biodiesel, Energy & Fuel, 2011, 25, pp. 2671–
2678 (ACS) (Q1)
Hayyan A., . Mjalli F.S, Hashim M.A., Hayyan
M., AlNashef I.M., Al-Zahrani S.M., Al-Saadi
M.A, Ethanesulfonic Acid-based Esterification
of Industrial Acidic Crude Palm Oil for Biodiesel
Production. Bioresource Technology 2011 Vol.
102, No. 20, pp. 9564-9570 (Elsevier) (Q1)
5
S.Nosrati, N.S. Jayakumar, M.A. Hashim,
Performance evaluation of supported ionic liquid
membrane for removal of phenol, Journalof
Hazardous Materials, 2011, 192 ,1283–1290
6
Rahul Kumar Goyal, N.S.Jayakumar, M.A.Hashim,
Emulsion stabilization using ionic liquid [BMIM]
+ [NTf2] and performance evaluation on the
extraction of chromium, Journal of Hazardous
Materials, 2011, 195, 55– 61
7
Rahul Kumar Goyal, N.S.Jayakumar,
M.A.Hashim, A comparative study of
experimental optimization and response surface
optimization of Cr removal by emulsion
ionic liquid membrane, Journal of Hazardous
Materials, 2011, 195, 383– 390
8
Rahul Kumar Goyal, N.S.Jayakumar,
M.A.Hashim, Chromium removal by emulsion
liquid membrane using [BMIM] as stabilizer
and TOMAC as extractant + [NTf2] , 2011,
Desalination 278, 50–56
9
Maqsood Ahmad Malik, Mohd Ali Hashim,
Firdosa Nabi, Ionic liquids in supported
liquid membrane technology, 2011, Chemical
Engineering Journal 171, 242–254
10 S.M. Shafie, T.M.I. Mahlia, H.H. Masjuki, A.
Andriyana. Current energy usage and sustainable
energy in Malaysia: A review. Renewable and
Sustainable Energy Reviews. 15 (2011) 4370-7.
11 A.S. Silitonga, A.E. Atabani, T.M.I. Mahlia, H.H.
Masjuki, I.A. Badruddin, S. Mekhilef. A review
on prospect of Jatropha curcas for biodiesel in
Indonesia. Renewable and Sustainable Energy
Reviews. 15 (2011) 3733-56.
12 H. A. Rahman, S. W. Harun, M. Yasin, S. W.
Phang, S. S. A. Damanhuri, H. Arof and H.
Ahmad, “Tapered plastic multimode fiber sensor
for salinity detection,” Sensors and Actuators A;
Physical, vol. 171, pp. 219-222, 2011.
13 L.K Tham, N.A Abu Osman, K.S Lim, B.
Pingguan-Murphy, W.A.B Wan Abas,and N.
Mohd Zain.(2011) Investigation to predict patellar
tendon reflex using motion analysis technique.
Medical Engineering & Physics. Vol. 33(4). pp
407-411 doi:10.1016/j.medengphy.2010.11.002
14 N.Yusoff, N.A.Abu Osman, Belinda PingguanMurphy. (2011). Design and Validation of a
Bi-axial Loading Bioreactor for Mechanical
Stimulation of Engineered Cartilage. Medical
Engineering & Physics. Vol. 33(6) pp. 782-788.
doi:10.1016/j.medengphy.2011.01.013
15 E.K.Moo, N.A.Abu Osman and B.PingguanMurphy. (2011). The Dynamics of Metabolism
of Cartilage Explants over a Long-Term Culture
Period. Clinics. vol.66(8): pp.1431-1436
16 Abnisa F, Daud WMAW, Husin WNW, Sahu JN.
Utilization possibilities of palm shell as a source
of biomass energy in Malaysia by producing
bio-oil in pyrolysis process. Biomass Bioenerg
2011;35:1863-1872.
17 Abnisa F, Wan Daud WMA, Sahu JN.
Optimization and characterization studies on
bio-oil production from palm shell by pyrolysis
using response surface methodology. Biomass
Bioenerg 2011; 35 (8):3604-3616
High Impact Research Annual Report 2012
18 Nazir R, Mazhar M, Wakeel T, Akhtar MJ,
Siddique M, Nadeem M, Khan NA, Shah R.
Pyrolysis Mechanism of Trisbipyridineiron(II)
Chloride to Iron Nanoparticles. J. Therm Anal
Calorim (2011) DOI:10.1007/s10973-011-1919-5
19 A.Eshraghi, H. Gholizadeh, and N.A. Abu Osman.
(2011). “Comments on Assessment of amputee
socket-stump-residual bone kinematics during
strenuous activities using Dynamic Roentgen
Stereogrammetric Analysis”. Journal of
Biomechanics. Vol.44 (16),pp 2851-2852
20 Gholizadeh H, Abu Osman N.A, .G. L v d ttir, A.
Eshraghi, M. Kamyab, W.A.B. Wan Abas, (2011)
A new approach for the pistoning measurement
in transtibial prosthesis. Prosthetics and
Orthotics International. Vol.35 (4) pp 366-370
21 M. Mohammadnejad, M. Ghazvini, T.M.I. Mahlia,
A. Andriyana. A review on energy scenario and
sustainable energy in Iran. Renewable and
Sustainable Energy Reviews. 15 (2011) 4652-8.
22 A.S. Silitonga, A.E. Atabani, T.M.I. Mahlia, A.H.
Sebayang. Techno-economic analysis and
environmental impact of fuel economy labels for
passenger cars in Indonesia. Renewable and
Sustainable Energy Reviews. 15 (2011) 5212-7.
23 R. Saidur, E.T. Elcevvadi, S. Mekhilef, A. Safari,
H.A. Mohammed. An overview of different
distillation methods for small scale applications.
Renewable and Sustainable Energy Reviews. 15
(2011) 4756-64.
24 Nazir R, Mazhar M, Wakeel T, Akhtar MJ,
Siddique M, Nadeem M, Khan NA, Shah R.
Pyrolysis Mechanism of Trisbipyridineiron(II)
Chloride to Iron Nanoparticles. J. Therm Anal
Calorim (2011) DOI:10.1007/s10973-011-1919-5
25 R. Saidur, M. Hasanuzzaman, T.M.I. Mahlia,
N.A. Rahim, H.A. Mohammed. Chillers energy
consumption, energy savings and emission
analysis in an institutional buildings. Energy. 36
(2011) 5233-8.
26 A. Mahmoudi, N. A. Rahim, W. P. Hew “An
Analytical Complementary FEA Tool for
Optimizing of Axial-Flux Permanent-Magnet
Machines” International Journal of Applied
Electromagnetics and Machines (IJEAM), Vol.
37, No. 1, 19-34, September 2011. (ISI/SCOPUS
Cited Publication)
27 A. Mahmoudi, N. A. Rahim, W. P. Hew “Genetic
Algorithm and Finite Element Analysis for
Optimum Design of Slotted TORUS AxialFlux Permanent-Magnet Brushless DC Motor”
Progress In Electromagnetics Research B (PIER
B), Vol. 33, 383-407, 2011. (SCOPUS Cited
Publication).
28 A. Mahmoudi, N. A. Rahim, W. P. Hew “Axial-Flux
Permanent-Magnet machine Modeling, Design,
Simulation, and Analysis: A Comprehensive
Review” Scientific Research and Essays (SRE),
Vol. 6, No. 12, June 2011, pp. 2525-2549.
(SCOPUS Cited Publication)
29 A. Mahmoudi, N. A. Rahim, W. P. Hew “TORUS
and AFIR Axial-Flux Permanent-Magnet
Machines: A Comparison via Finite Element
Analysis” International Review on Modelling and
Simulations (IREMOS), Vol. 4, No. 2, April 2011,
pp. 624-631. (SCOPUS Cited Publication)
30 Khalaf Salloum Gaied, Hew Wooi Ping, 2011.
Wavelet fault diagnosis and tolerant of induction
motor: a review, International Journal of the
Physical Sciences, Vo. 6(3), 358-376 (ISI-Cited
Publication)
31 M. Hayyan, F.S. Mjalli, M. A. Hashim, I. M.
AlNashef Generation of Superoxide Ion in
Pyridinium, Morpholinium, Ammonium, and
Sulfonium Based Ionic Liquids and Its Use in
the Destruction of Toxic Chlorinated Phenols
Industrial & Engineering Chemistry Research,
2012, DOI: 10.1021/ie3006879 (ACS). (Q1)
32 K. Shahbaz, S. Barotian, F. S. Mjalli, M. A.
Hashim, I. M. AlNashef Prediction of Glycerol
Removal from Biodiesel using Ammonium
and Phosphunium Based Deep Eutectic
Solvents using Artificial Intelligent Techniques
Chemometrics and Intelligent Laboratory
Systems (accepted, in press) 2012 (Elsevier) (Q1)
33 K. Shahbaz, S. Barotian, F. S. Mjalli, M. A.
Hashim, I. M. AlNashef Densities and Viscosities
of Binary Blends of Methyl Esters + Ethyl Esters
and Ternary Blends of Methyl Esters + Ethyl
Esters + Diesel Fuel from T = (293.15 to 358.15)
K Chemical Engineering Data, 2012, 57(5), 13871395 (ACS) (Q1)
34 Adeeb Hayyan, Mohd Ali Hashim, Farouq S.
Mjalli, Maan Hayyan, Inas M. AlNashef. A Novel
Phosphonium-Based Deep Eutectic Catalyst
for Biodiesel Production from Low grade
Crude Palm Oil. Chemical engineering science,
10.1016/j.ces.2012.12.024 (Elsevier) Q1
35 A.H.Halim Abu Bakar, H.Mokhlis, H.A.Illias, P.L.
Chong, “The study of Directional Overcurrent
Relay and Directional Earth-Fault Protection
application for 33 kV Underground Cable System
in Malaysia”, International Journal of Electrical
Power and Energy System,Vol.40, Issue 1, Pages
113-119,September 2012 (ISI/SCOPUS Cited
Publication)
36 M.Karimi, H.Mohamad, H.Mokhlis, A.H.A Bakar,
“Under-Frequency Load Shedding Scheme for
Islanded Distribution Network Connected with
Mini Hydro” International Journal of Electrical
Power and Energy Systems, Vol. 42, Issue
1,November 2012, Pages 127-138. (ISI/SCOPUS
Cited Publication)
37 M.M. Aman, G.B. Jasmon, H. Mokhlis, A.H.A.
Bakar, “Optimal Placement and Sizing of A DG
based on a New Power Stability Index and Line
Losses”, International Journal of Electrical Power
and Energy System,Vol.43, Issue 1, December
2012, Pages 1296-1304 (ISI/SCOPUS Cited
Publication)
38 M. Hayyan, F. S. Mjalli, M. A. Hashim, I.
M. AlNashef, X. M. Tan Investigating the
Electrochemical Windows of Ionic Liquids.
Journal of Industrial and Engineering Chemistry,
2012, 19, 106-112. (Elsevier)
39 M.Karimi, H.Mohamad, H.Mokhlis, A.H.A.
Bakar, “A New Approach of Under-Frequency
Load Shedding Technique in an Islanded
Distribution Network”,International Review of
39
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High Impact Research Annual Report 2012
Electrical Engineering (IREE), Vol. 6, N.2, page:
4155-4162,Part b, March-April 2012 (ISI-Cited
Publication)
40 Maan Hayyan, Mohd Ali Hashim, Adeeb Hayyan,
Mohammed A. Al-Saadi, Inas M. AlNashef,
Mohamed E.S. Mirghani, Olorunnisola Kola
Saheed. Are Deep Eutectic Solvents Benign
or Toxic? Chemosphere, Doi: 10.1016/j.
chemosphere.2012.11.004, 2012.( Elsevier)
41 A B M Saiful Islam, Raja Rizwan Hussain,
Mohammed Jameel, Mohd Zamin Jumaat.
Nonlinear time Domain analysis of base
isolatedmultistorey building under site specific
bidirectional seismic loading Automation in
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Growth-Inhibitory Effect in Various Cancer Cell
lines and Apoptosis in Ca Ski Human Cervical
Epidermoid Carcinoma Cells. EvidenceBased Complementary and Alternative
Medicine. Vol. 2011, (2011), 13 pages,
doi:10.1155/2011/293060
4
Amid M., Tan C. P., Mirhosseini H., Norashikin
Ab. Aziz, Ling, T.C. Optimisation of freeze drying
conditions for purified serine protease from
mango (Mangifera Indica Cv. Chokanan) peel,
Food Chemistry, 128, (2011) 158-164.
5
Show, P.L., Tan, C.P., Anuar, M.S., Ariff, A., Yusof,
Y.A., Chen, S.K., Ling, T.C. Direct recovery of
lipase derived from Burkholderia Cepacia with
aqueous two-phase flotation, Separation and
Purification Technology, 80, (2011) 577 - 584.
6
Nor Adila Mhd Omar, Noorlidah Abdullah,
Umah Rani Kuppusamy, Mahmood Ameen
Abdulla and Vikineswary Sabaratnam (2011).
Nutritional composition, antioxidant capacity
and antiulcer potential of Lentinus squarrosulus
(Mont.) mycelia extract. Evidenced-Based
Complementary and Alternative Medicine.
volume 2011,doi:10.1155/2011/539356 (ISI-Cited
Publication)
7
Mahmood Ameen Abdulla, Atieh Abdollahi
Fard, Vikineswary Sabaratnam, Kah-Hui Wong,
Umah Rani Kuppusamy, Noorlidah Abdullah
and Salmah Ismail (2011). Potential activity of
aqueous extract of culinary-medicinal Lion’s
Mane mushroom, Hericium erinaceus (Bull.: Fr.)
Pers. (Aphyllophoromycetideae) in accelerating
wound healing in rats. International Journal of
Medicinal Mushrooms (IJMM)13(1): 33-39
8
Kah-Hui Wong, Murali Naidu, Pamela David,
Mahmood Ameen Abdulla, Noorlidah Abdullah,
Umah Rani Kuppusamy, and Vikineswary
Sabaratnam. Peripheral Nerve Regeneration
Following Crush Injury to Rat Peroneal Nerve
by Aqueous Extract of Medicinal Mushroom
Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoro
mycetideae). Evidence-Based Complementary
and Alternative Medicine Volume 2011, Article
ID 580752, 2011, 10 pages doi:10.1093/ecam/
neq062
9
Zukerman-Schpector, J., Otero-de-la-Roza, A.,
Luan . & Tiekink, E.R.T. 2011. Supramolecular
architectures based on As(lone pair).pi(aryl)
interactions. Chemical Communications 47:76087610.
135 Khalaf Salloum Gaeid, Hew Wooi Ping, Mustafa
Khalid, Ammar Masaoud, 2012. Sensor and
sensorless fault tolerant control for induction
motors using a wavelet index. Sensors 2012, 12,
4031-4050. (ISI-Cited Publication)
136 A. Mahmoudi, S. Kahourzade, N. A. Rahim,
and H. W. Ping “Optimum Design of an InsideOut Axial-Flux Permanent-Magnet Motor using
Genetic Algorithm and Finite Element Analysis”
International Review of Electrical Engineering
(IREE), Vol. 7, No. 2, 3814-3827, 2012. (ISI/
SCOPUS Cited Publication)
137 E.Sadeghinezhad, S.N.Kazi, M.Dahari,
Mohammad Reza Safaei, Rad Sadri, A.
Badarudin, A comprehensive review of milk
fouling on heated surfaces, J. Critical Reviews
in Food Science and Nutrition, Accepted in Nov
2012
FACULTY OF SCIENCE
1
2
3
ZX Ng, UR Kuppusamy, I Tajunisah, Kenneth
CSF, Adrian CAK, KH Chua. 2011. 2245G/A
polymorphism of the receptor for advanced
glycation end-products (RAGE) gene is
associated with diabetic retinopathy in the
Malaysian population. British Journal of
Ophthalmology 96(2): 289-292
Amid M., Tan C. P., Mirhosseini H., Norashikin
Ab. Aziz, Ling, T.C. Optimisation of serine
protease extraction from mango peel (Mangifera
Indica Cv. Chokanan), Food Chemistry, 124,
(2011) 666 671.
Yan Hsiung Wong & Habsah Abdul Kadir.
Leea indica Ethyl Acetate Fraction Induces
10 Tiekink, E.R.T. & Zukerman-Schpector, J. 2011.
Emerging supramolecular synthons: C-H.
pi(chelate) interactions in metal bis(1,1-dithiolates).
Chemical Communications 47:6623-6625.
11 I. Ling, Y. Alias, A. N. Sobolev, B. W. Skelton and
C. L. Raston. Site specific Co(III) sarcophagine
binding in multi-component phosphonium
and p-sulfonatocalix[4]arene systems. Dalton
Transactions (2011), 40, 10337-10344.
12 M.R. Mahmoudian, W.J. Basirun and Y. Alias and
A. Khorsand Zak. Electrochemical characteristics
of coated steel with poly(N-methyl pyrrole)
synthesized in presence of ZnO nanoparticles.
Thin Solid Films (2011), 520, 258–265
High Impact Research Annual Report 2012
13 S. J. Tan, W. T. Robinson, K. Komiyama,
T. S. Kam, Macrodasine A-G, macroline
indole alkaloids incorporating fused
spirocyclic tetrahydrofuran-tetrahydrofuran
and tetrahydrofuran-tetrahydropyran rings,
Tetrahedron, 2011, 67, 3830-3838.
24 Eik, L. F., Naidu M., David, P. Wong, K. H., Tan, Y.
S. & Sabaratnam V., (2012). Lignosus rhinoceros
(Cooke) Ryvarden: A Medicinal Mushroom that
stimulates neurite outgrowth in PC-12 Cells.
Journal of Evidence-Based Complementary and
Alternative Medicine.
14 W. F. Ku, S. J. Tan, Y. Y. Low, K. Komiyama, T.
S. Kam, Angustilobine and andranginine type
indole alkaloids and an uleine-secovallesamine
bisindole alkaloid from Alstonia angustiloba,
Phytochemistry, 2011, 72, 2212-2218.
25 Reddy NS, Navanesan S, Sinniah SK, Wahab NA
and Sim KS. 2012. Phenolic content, antioxidant
effect and cytotoxic activity of Leea indica
leaves. BMC Complementary and Alternative
Medicine 12: 128
15 S. H. Lim, S. J. Tan, Y. Y. Low, T. S. Kam,
Lumutinines A-D, Linearly Fused MacrolineMacroline and Macroline-Sarpagine Bisindoles
from Alstonia macrophylla, J. Nat. Prod., 2011,
74, 2556-2562.
26 Phan Chia Wei, Wong Wei Lun,, Pamela David,
Murali Naidu and Vikineswary Sabaratnam
(2012). Pleurotus giganteus (Berk) Karunarathna
& K.D. Hyde: Nutritional value and in vitro neurite
outgrowth activity rat pheochromocytoma cells.
BMC Complementary and Alternative Medicine.
12:102
16 Nazir R, Mazhar M, Wakeel T, Akhtar MJ,
Siddique M, Nadeem M, Khan NA, Shah R.
Pyrolysis Mechanism of Trisbipyridineiron(II)
Chloride to Iron Nanoparticles. J. Therm Anal
Calorim (2011) DOI:10.1007/s10973-011-1919-5
17 Yusof, N. S.; Khan, M. N. Kinetic and rheological
measurements of the effects of inert 2-, 3- and
4-bromobenzoate ions on the cationic micellarmediated rate of piperidinolysis of ionized phenyl
salicylate J. Colloid Interface Sci. 2011, 357,
121-128
18 Sim, Y. L.; Yusof, N. S.; Ariffin, A.; Khan, M.
N. Effects of nonionic micelles on the rate of
alkaline hydrolysis of N-(2’-methoxyphenyl)
phthalimide (1):Kinetic and rheometric evidence
for a transition from spherical to rodlike micelles
uder the typical reaction conditions. J. Colloid
Interface Sci. 2011, 360, 182-188
19 Zukerman-Schpector, J., Haiduc, I. & Tiekink,
E.R.T. 2011. The metal carbonyl p(aryl)
interaction as a supramolecular synthon for the
stabilisation of transition metal carbonyl crystal
structures. Chemical Communications 47: 12682
12684.
20 S. F. Norizan, W. Y. Chong, S. W. Harun, H.
Ahmad, “O-band Bismuth-doped fibre amplifier
with double-pass configuration,” IEEE Photonics
Technology Letters, vol. 23, no. 24, pp. 18601862, 2011.
21 Wei-Lun Wong, Mahmood Ameen Abdulla,
Kek-Heng Chua,Umah Rani Kuppusamy, YeeShin Tan and Vikineswary Sabaratnam. 2012.
Hepatoprotective effects of Panus giganteus
(Berk.) Corner against thioacetamide (TAA)induced liver injury in rats. Evidence based
Complementary and Alternative Medicine.
22 Yan Hsiung Wong & Habsah Abdul Kadir.
Induction of Mitochondria-Mediated Apoptosis
in Ca Ski Human Cervical Cancer Cells Triggered
by Mollic Acid Arabinoside Isolated from Leea
indica. Evidence-Based Complementary and
Alternative Medicine. Vol. 2012, (2012), 11 pages,
doi:10.1155/2012/684740
23 Lau, C. C., Noorlidah, A., Shuib, A. S. and
Aminudin, N. 2012. Proteomic Analysis of
Antihypertensive Proteins in Edible Mushrooms.
J. Agric. Food Chem., 60 : 12341-12348.
27 Kanagasabapathy G, Kuppusamy UR, Abd
Malek SN, Abdulla MA, Chua K, Sabaratnam
V. 2012. Glucan-rich polysaccharides from
Pleurotus sajor-caju (Fr.) Singer prevents glucose
intolerance, insulin resistance and inflammation
in C57BL/6J mice fed a high-fat diet BMC
Complementary and Alternative Medicine. 12:261
28 Feroz, Shevin, Mohamad, Saharuddin, Bujang,
Noraini, Abd Malek, Sri Nurestri, Tayyab, Saad.
(2012). Multi-spectroscope and Molecular
Modeling Approach to Investigate the Interaction
of Flavokawain B with Human Serum Albumin.
Accepted in Journal of Agricultural and Food
Chemistry.
29 M. S. Zaroog and S. Tayyab (2012) Formation
of molten-globule-like state during acid
denaturation of Aspergillus niger glucoamylase.
Process Biochemistry 47 (5): 775-784.
30 Ding, C.X., Li, X., Ding, Y.B., Li, X., Ng, S.W. &
Xie, Y.S. 2012 A novel bis(4,4-bipyridylamine)
ligand with a flexible butadiyne linker: syntheses,
structures, and photoluminescence of d10 metal
coordination polymers. Cryst. Growth Des. 12:
3465-3473.
31 Yan Hsiung Wong, Habsah Abdul Kadir & Sui
Kong Liong. Bioassay-guided Isolation of
Cytotoxic Cycloartane Triterpenoid Glycosides
from the Traditionally Used Medicinal Plant Leea
indica. Evidence-Based Complementary and
Alternative Medicine. Vol. 2012, (2012), 11 pages,
doi:10.1155/2012/164689
32 Gomathi Chan, Muhamad Noor Alfarizal
Kamarudin, Daniel Zin Hua Wong, Nor Hadiani
Ismail, Faizuri Abd. Latif, Aurengzeb Hasan,
Khalijah Awang & Habsah Abdul Kadir. 2012.
Mitigation of H2O2-induced mitochondrialmediated apoptosis in NG108-15 cells by novel
mesuagenin C from Mesua kunstleri (King)
Kosterm.Evidence-Based Complementary and
Alternative Medicine. Volume 2012 (2012), Article
ID 156521, 18 pages doi:10.1155/2012/156521
33 Selvakumar, P., Ling, T.C., Walker, S., Lyddiatt, A.
(2012),Recovery of glyceraldehyde 3-phosphate
dehydrogenase from an unclarified disrupted
yeast using aqueous two-phase systems
facilitated by distribution analysis of radio
45
46
High Impact Research Annual Report 2012
labelled analytes, Separation and Purification
Technology, 85,28 - 34.
34 Mehdi Ebadi, Wan Jeffrey Basirun, Yatimah Alias,
Mohammad Reza Mahmoudian, and Sim Yoke
Leng. Investigation of electrodeposition of Ni Co
Fe Zn alloys in DMSO with MHD effect. Materials
Characterization (2012), 66, 46-55.
45 Ng, H. S., Tan, C. P., Mokhtar, M. N., Ibrahim,
S., Ariff, A., Ooi, C. W., Ling, T. C. (2012),
Recovery of Bacillus cereuscyclodextringly
cosyltransferase and recycling of phase
components in an aqueous two-phase system
using thermo-separating polymer, Separation
and Purification Technology,89: 9 - 15.
35 I. Ling, Y. Alias, A. N. Sobolev, B. W. Skelton
and C. L. Raston. Conformationally Flexible
p-Sulfonated Calix[5]arene Binding with Large
Bis-Phosphonium Cations. Cryst. Growth Des.
(2012), 12, 1564−1570
46 S. H. Lim, Y. Y. Low, S. J. Tan, K. H. Lim, N.
F. Thomas, T. S. Kam, Perhentidines A–C:
macroline-macroline bisindoles from Alstonia and
the absolute configuration of perhentinine and
macralstonine, J. Nat. Prod., 2012, 75, 942-950.
36 I. Ling, Y. Alias, A. N. Sobolev, B. W. Skelton and
C. L. Raston. Inclusion controlled lanthanide
– imidazolium functionalised carboxylate
complexation. Dalton Transactions (2012), 41,
4884-4889
47 C.H Pua, H.ahmad, S.W Harun, RM De La Rue,
“Study of Dual Wavelength Mode Competition in
an Erbium Doped Fiber Laser (EDFL) Produced
by Aciustic Waves, IEEE Journal of Quantum
Electronics, vol 48, no12, pp 1499-1504, 2012
37 M.R. Mahmoudian, W.J. Basirun and Y. Alias.
The electrical properties of a sandwich of
electrodeposited polypyrrole nanofibers between
two layersof reduced graphene oxide nanosheets.
Electrochimica Acta (2012), 72, 53-60
48 S. J. Tan, G. Subramaniam, N. F. Thomas, T.
S. Kam, Unusual nitrogenous derivatives from
Alstonia, Natural Product Communications, 2012,
7, 739-742.
38 M.R. Mahmoudian, W.J. Basirun and Y. Alias.
Preparation of ultra-thin polypyrrole nanosheets
decorated with Ag nanoparticles and their
application in hydrogen peroxide detection.
Electrochimica Acta (2012), 72, 46-52.
39 I. Ling, Y. Alias, A. N. Sobolev, B. W. Skelton and
C. L. Raston. Axially Aligned Confinement of
1,4-Bis(triethylammoniomethyl)benzene by Two
p-Sulfonatocalix[4]arenes. Aust. J. Chem. (2012),
65, 755–762.
40 Mehdi Ebadi, Wan Jeffrey Basirun, Yatimah
Alias, Mohammad Reza Mahmoudian, and
Sim Yoke Leng. Investigation of Corrosion
Inhibition Properties of Caffeine on Nickel by
Electrochemical Techniques. Int. J. Electrochem.
Sci. (2012), 7, 8052 – 8063.
49 S. J. Tan, K. H. Lim, G. Subramaniam, T. S.
Kam, Macroline-sarpagine and macrolinepleiocarpamine bisindole alkaloids from Alstonia
angustifolia, Phytochemistry, 2013, 85, 194-202
(Submitted 22 May 2012, Accepted June 2012,
Available online September 2012).
50 R. E. Ziegler, S. J. Tan, T. S. Kam, J. A. Porco,
Development of an alkaloid-pyrone annulation:
Synthesis of pleiomaltinine Angew. Chem. Int.
Ed., 2012, 51, 9348-9351.
51 S. H. Lim, Y. Y. Low, G. Subramaniam, A.
Zanariah, N. F. Thomas, T. S. Kam, Lumusidines
A-D and villalstonidine F, macroline-macroline
and macroline-pleiocarpamine bisindole alkaloids
from Alstonia macrophylla, Phytochemistry,
2012, Article ASAP ( DOI: 10.1016/j.
phytochem.2012.11.005).
41 M.R. Mahmoudian, Y. Alias and W. J. Basirun.
Effect of narrow diameter polyaniline nanotubes
and nanofibers in polyvinyl butyral coating on
corrosion protective performance of mild steel.
Progress in Organic Coatings (2012), 75, 301-308.
52 A.M. Golsheikh, N.M. Huang, H.N. Lim, C.H.
Chia, I. Harrison, M.R. Muhamad. One-Pot
Hydrothermal Synthesis and Characterization
of FeS2 (Pyrite)/Graphene Nanocomposite.
Chemical Engineering Journal (2012).
DOI:10.1016/j.cej.2012.09.082
42 Irene Ling, K. Swaminathan Iyer, Charles S.
Bond, Alexandre N. Sobolev, Yatimah Alias
and Colin L. Raston. Sodium ion association
via bridging water molecules for different
charged p-phosphonated calix[4]arene bilayers.
CrystEngComm (2012), 14, 8541-8546
53 Boon Tong Goh, Siew Kien Ngoi, Seong Ling
Yap, Chiow San Wong, Saadah Abdul Rahman.
Effect of energetic ion beam irradiation on
structural and optical properties of a-Si:H thin
films. Thin Solid Films (2012). DOI:10.1016/j.
tsf.2012.07.072
43 Show, P. L., Tan, C. P., Anuar, M. S., Ariff, A.,
Yusof, Y. A., Chen, S. K., Ling, T. C. (2012),
Primary recovery of lipase and recycling phase
components in aqueous two-phase system,
Biochemical Engineering Journal, 60, 74 - 80.
54 Boon Tong Goh, Siew Kien Ngoi, Seong Ling
Yap, Chiow San Wong, Chang Fu Dee, Saadah
Abdul Rahman. Structural and optical properties
of the nc-Si:H thin films irradiated by high
energetic ion beams. Journal of Non-Crystalline
Solids (2012).
44 Noorlidah Abdullah, Siti Marjiana Ismail,
Norhaniza Aminudin, Adawiyah Suriza Shuib
and Lau Beng Fye (2012). Evaluation of selected
culinary-medicinal mushrooms for antioxidant
and ACE inhibitory activities. Evidenced-Based
Complementary and Alternative Medicine.
doi:10.1155/2012/464238. 13 pages (ISI/
SCOPUS Cited Publication)
55 Su Kong Chong, Boon Tong Goh, Chang
Fu Dee, Saadah Abdul Rahman. Effect of
substrate to filament distance on formation
and photoluminescence properties of indium
catalyzed silicon nanowires using hot-wire
chemical vapor deposition. Thin Solid Films
(2012). DOI:10.1016/j.tsf.2012.07.098
High Impact Research Annual Report 2012
56 Su Kong Chong, Boon Tong Goh, Chang Fu
Dee, Saadah Abdul Rahman. Study on the role
of filament temperature on growth of indiumcatalyzed silicon nanowires by the hot-wire
chemical vapor deposition technique. Materials
Chemistry and Physics (2012). DOI:10.1016/j.
matchemphys.2012.05.037
57 Su Kong Chong, Boon Tong Goh, Yuen-Yee
Wong, Hong-Quan Nguyen, Hien Do, Ishaq
Ahmad, Zarina Aspanut, Muhamad Rasat
Muhamad, Chang Fu Dee, Saadah Abdul
Rahman. Structural and photoluminescence
investigation on the hot-wire assisted plasma
enhanced chemical vapor deposition growth
silicon nanowires. Journal of Luminescence
(2012). DOI:10.1016/j.jlumin.2012.01.026
58 Yusof, N. S.; Khan, M. N.; Ashokkumar, M.
Characterization of the Structural Transitions in
CTAB Micelles Using Fluorescein Isothiocyanate.
J. Phys.Chem. C 2012, 116, 15019-15027
59 Yusof, N. S.; Khan, M. N. Quantitative Correlation
of Counterion (X) Affinity to Ionic Micelles and
X- and Temperature-Induced Micellar Growth
(Spherical - Wormlike Micelles - Vesicles) for X =
5-Methyl- and 5-Methoxysalicylate Ions. J. Phys.
Chem. B 2012, 116, 2065-2074
60 N.S Shahbudin, S.J Tan , M.A Ismail, H.Ahmad,
Z.Yusoff, S.W Harun “Multi-wavelength fiber
laser based on nonlinear polarization rotation in
semiconductor optical amplfier and photonics
crystal fiber” Laser Physics, vol 22, no 7, pp
1257-1259, 2012.
61 H.Ahmad, K Thambiratnam, N.A Awang , M.H
Jemangin, S.W Harun,” Stable zirconia-erbium
doped multiwavelength fiber laser by precise
control of pollarization states” Laser Physics, vol
22, no 5, pp 982-985, 2012.
62 H. Fatehi, S.D Emami, A.Zarifi, F.Z Zahedi, S.E
Mirnia, A.Zarei, H.Ahmad, S.W.Harun” Analytical
Model for Broadband Thulium-Bismuth Doped
Fiber Amplifier”, IEEE Journal of Quantum
Electronics, vol 48, no8, pp 1052-1058, 2012
63 H.F. Goh and K. Philip (2012) Isolation and
Identification of lactic acid bacteria with
antimicrobial properties from fermented food
products. Canadian Journal of Microbiology
64 Goh Hweh Fen,Koshy Philip, Sekaran Muniandy
(2012) Antimicrobial Peptides From Indigenous
Fermented Cow Milk. Applied Microbiology and
Biotechnology.
65 Abdelahhad Barbour, Koshy Philip and Sekaran
Muniandy (2012). Isolation, purification and
antimicrobial action of bacteriocin produced
by Streptococcus salivarius NU10 isolated
from a Malaysian subject (submitted to BMC
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66 Abdul-Mushin M. Shami, Koshy Philip,
and Sekaran Muniandy (2012). Synergy of
antibacterial and antioxidant activities from crude
extracts and peptides of selected plant mixture.
67 Abdul-Mushin M. Shami, Koshy Philip, and
Sekaran Muniandy (2012). Antibacterial and
antioxidant effects of crude extracts and
peptides from Morinda citrifolia and Annona
squamosa.
68 K.S Lim, I.Arynfar, W.Y Chong, Y.K Cheong,
S.W. Harun,H.Ahmad “Intergrated Micro Device
for Refractive Index and Temperature Sensing”,
Sensors, vol 12, no9, pp 11782-11789, 2012
69 Hockseng Nguan, Sara Ahmadi and Rauzah
Hashim, 2012, DFT study of glucose based
glycolipid crown ethers and their complexes
with alkali metal cations Na+ and K+, Journal
of Molecualr Modeling,18(12):5041-50. (doi:
10.1007/s00894-012-1497-x)
70 Kamalul Aripin, Nurul Fadhilah; Hashim, Rauzah;
Heidelberg, Thorsten; Kweon, Dong-Keon; Park,
Hyun Jin, Effect of vesicle s membrane packing
behaviour on skin penetration of model lipophilic
drug, Journal of Microencapsulation, 2012, 1 9.
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71 Faramarz Aliasghari Sani, Thorsten Heidelberg,
Rauzah Hashim and Farhanullah, 2012, Alkyl
triazole glycosides (ATGs) A new class of bio
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B: Biointerfaces,97, 196 200 http://dx.doi.
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72 S.D Emami, H.A Abd Rashid, S.Z.M Yasin,
K.A.M Shariff, S.E Mirnia, A.Parvizi, H.Ahmad,
S.W Harun, “S-band gain and noise figure
improvement in thulium-doped fiber amplfiers by
using macro-bending approach”,Applied Physics
B-Laser and Optics, vol 108, no 4, pp 807-813,
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73 Tiekink, E.R.T. 2012. Therapeutic potential
of selenium and tellurium compounds:
Opportunities yet unrealised. Dalton Transactions
41:6390-6395.
74 Cain, N.M., Tiekink, E.R.T. & Taylor, D.K. 2012.
Ozonolysis of Bicyclic 1,2-Dioxines: Initial Scope
and Mechanistic Insights. Journal of Organic
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75 Caracelli, I., Zukerman-Schpector, J. & Tiekink,
E.R.T. 2012. Supramolecular aggregation
patterns based on the bio-inspired Se(lone
pair)...pi(aryl) synthon. Coordination Chemistry
Reviews 256:412-438.
76 Jorda, A.K., Ferreira, V.F., Cunha, A.C., Wardell,
J.L., Wardell, S.M.S.V. & Tiekink, E.R.T.
2012. The differing influence of halides upon
supramolecular aggregation through C-X...pi
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77 S.J Tan, S.W.Harun, N.S Shahbuddin,
H.Arof, H.Ahmad, “Dual-cavity dual output
multiwavelength fiber laser based in nonlinear
polarization rataion effect”, Laser Phisics, vol 22,
no 10, pp 1601-1605, 2012
78 Zukerman-Schpector, J., Haiduc, I. & Tiekink,
E.R.T. (2012). Supramolecular self-assembly of
transition nmeal carbonyl molecules through M
CO(lone pair)...pi (arene) interactions. Advances
in Organometallic Chemistry 60:49-92.
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79 Ratnavelu K, Choong KF and Ujum A E, Interjournal citations and Ranking Top journals in
Financial research, Communications in Computer
and Information Science Volume: 283 Pages:
505-513 Published: 2012 (ISI publication)
81 I. Arynfar, K.S.Lim, W.Y Chong, S.W.Harun, H.
Ahmad, “Add-Drop Filter Based on Microfiber
Mach-Zehnder/Sagnac Interferometer”,IEEE
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82 H. Ahmad, M. Z. Zulkifli, N. A. Hassan, S.
W. Harun, “Enhancement of Brillioun Stokes
generation in the S-band region using a
combination S-band Depressed Cladding
Erbium Doped Fiber and Semiconductor Optical
Amplifier,” Laser Physics, vol. 22, no. 3, pp. 598604, 2012.
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Chai WL, Brook IM, Palmquist A, van Noort
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Malhotra R, Patel V, Chikkaveeraiah BV, Munge
BS, Cheong SC, Zain RB, Abraham MT, Dey DK,
Gutkind JS, Rusling JF. Ultrasensitive Detection
of Cancer Biomarkers in the Clinic using a
Nanostructured Microfluidic Array. Anal Chem
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Ramanthan A., Yang YH, Mustafa WMW,
Prepageran N. Survival of oral squamous
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Vincent-Chong VK, Anwar A, Karen-Ng LP,
Cheong SC, Yang Y-H, Pradeep PJ, Rahman
ZAA, Ismail SM, Zaini ZM, Prepageran N,
Kallarakkal TG, Ramanathan A, Mohayadi
NABM, Rosli NSBM, Mustafa WMW, Mannil
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Chromosomal Alterations in Oral Squamous Cell
Carcinomas Revealed Over Expression of MGAM
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83 R. Parvizi, N. M. Ali, S. W. Harun, S. D. Emami,
H. Ahmad, “Multi-wavelength Brillouin fiber laser
generation using dual-pass approach,” Laser
Physics, vol. 22, no. 3, pp. 584-587, 2012.
84 W. Y. Chong, K. S. Lim, W. H. Lim, S. W. Harun,
F. R. M. Adikan, H. Ahmad, “Spreading profile
of evaporative liquid drops in thin porous layer,”
Physical Review E, vol. 85, no. 1, pp. 016314,
2012.
85 H.Ahmad, N.A Awang, M.Z.Zulkifli,
K.Thambiratnam, M.C Paul, S.Das, S.W harun,
“Supercontinum from Zr-EDF mode locked fiber
laser”, Laser Physics Letters, vol 9, no 1, pp 4449, 2012
86 H Ahmad, K. Thambiratnam, N.A Awang, Z.A
Ghani, S.Wharun,”Four-wave mixing in zirconiaerbium doped fiber -a comparison between ring
and linear cavities”, Laser Physics Letters, vol 9,
no 11, pp 819-825, 2012
87 K.S Lim, S.Yoo, M.C paul, H.Ahmad, M.Pal, S.L
Bhadra, J.K Sahu,” Tunable Laser in YtterbiumDoped Y2O3 Nanoparticle Optical Fibers” IEEE
Photonics Technologies Letters, vol 24, no 8, pp
679-681, 2012
FACULTY OF COMPUTER SCIENCE
INFORMATION AND TECHNOLOGY
1
Mumtaz, B.M., Siti, S. S., Noraini, M. A SeverityBased Acoustic Modelling Approach for
Automatic Speech Recognition and its use for
assessment of Speech Impairment. Journal of
Biomedical Informatics. Under Review since
20/08/2012, ISI-Cited Publication, Tier-2)
2
Muhammad Shiraz , Abdullah Gani, Rashid
Hafeez Khokar, Rajkumar Buyya A Review
on Application Processing Frameworks in
Mobile Devices for Mobile Cloud Computing
IEEE Communications Surveys and
Tutorials, IEEE (ACCEPTED, DOI: 10.1109/
SURV.2012.111412.00045, ISI Indexed Q1
(impact factor 6.3)).
3
Siti, S.S., Mumtaz, B.M., Noraini, M. The
acceptance and use of Speech technology
for pronunciation practice by children with
dysarthria: an analysis based on TAM.
Computers and Education, Under Review since
12/12/2012, ISI-Cited Publication, Tier 1)
4
Seyed Reza Shahamiri and Siti Salwa Binti Salim,
Automatic Dysarthric Speech-Recognition based
on Artificial Neural Networks: Identifying the
Best Performing Set of MFCC Parameters and
Proposing A Speaker-Independent Approach,
IEEE Transactions on Neural Systems and
FACULTY OF DENTISTRY
1
2
Noor Hayaty Abu Kasim, Vijayendran
Govindasamy, Nareshwaran Gnanasegaran,
Sabri Musa, Padmaja Jayaprasad Pradeep,
Thekkeparambil chandrabose Srijaya and Zeti
Adura Che Ab. Aziz. 2012. Unique molecular
signatures influencing the biological function
and fate of post-natal stem cells isolated from
different sources. Journal of Tissue Engineering
and Regenerative Medicine. DOI:10.1002/
term.1663 (Tier 1 paper)
Thekkeparambil Chandrabose Srijaya, Padmaja
Jayaprasad Pradeep, Rosnah Binti Zain, Sabri
Musa, Noor Hayaty Abu Kasim Vijayendran
Govindasamy. 2012. The promise of human
induced pluripotent stem cells in dental
research. Stem Cell International. 2012:1-10.
Doi:10.1155/2012/423868. (Scopus cited)
High Impact Research Annual Report 2012
Rehabilitation Engineering (2012) (under review)
(ISI/SCOPUS Cited Publication) - Tier 1
5
Seyed Reza Shahamiri and Siti Salwa Binti
Salim, Artificial Neural Networks as MultiNetworks Automated Speech Recognizers,
Neurocomputing, (2012) (under review) (ISI/
SCOPUS Cited Publication)
CHANCELLORY
1
Yee Meng Chong,Wai Fong Yin,Chia Yong
Ho, Mohamad Rais Mustafa,A. Hamid A.
Hadi,Khalijah Awang,Putri Narrima, Chong-Lek
Koh, David R. Appleton,and Kok-Gan Chan.
Malabaricone C from Myristica cinnamomea
Exhibits Anti Quorum Sensing Activity. J. Nat.
Prod., 2011, 74 (10), pp 2261–2264
2
Kok-Gan Chan, Steve Atkinson, Kalai Mathee,
Choon-Kook Sam, Siri Ram Chhabra, Miguel
C ra, Chong-Lek Koh, and Paul Williams.
2011. Characterization of N- Acylhomoserine
Lactone-Degrading Bacteria Associated with
the Zingiber officinale (ginger) rhizosphere: Coexistence of Quorum Quenching and Quorum
Sensing in Acinetobacter and Burkholderia. BMC
Microbiology 2011, 11:51 doi:10.1186/14712180-11-51
3
Yue-Jun Fu, Na An, Kok-Gan Chan, Yan-Bo Wu,
Shu-Hua Zheng, Ai-Hua Liang. 2011. A model
of BmK CT in inhibiting glioma cell migration via
matrix metalloproteinase-2 from experimental
and molecular dynamics simulation study.
Biotechnology letters 2011;33(7):1309-17.
4
Krishnamurithy G, Shilpa PN, Ahmad RE,
Sulaiman S, Ng CLL, Kamarul T. 2011. Human
Amniotic Membrane as a Chondrocyte Carrier
Vehicle/Substrate: In Vitro study. J Biomed Mater
Res Part A 2011:99A:500–506
5
Haw, C. Y., Chia, C. H., Zakaria, S., Mohamed, F.,
Radiman, S., Teh, C. H., Khiew, P. S., Chiu, W. S.
& Huang, N. M. 2011. Morphological studies of
randomized dispersion magnetite nanoclusters
coated with silica. Ceramics International 37:
451-464. (ISI-Cited Publication)
6
Sarmani, A. R.; Abu Bakar, M. H.; Bakar, A. A. A.;
Adikan, F. R. Mahamd; Mahdi, M. A.; Spectral
variations of the output spectrum in a random
distributed feedback Raman fiber laser ; OPTICS
EXPRESS, Vol. 19, Issue 15, pp. 14152 14159,
July 18 2011 (ISI-Cited Publication)
7
Ismail, Mohd. Afiq; Tamchek, Nizam; Abu
Hassan, Muhammad Rosdi; Dambul, Katrina
D.; Selvaraj, Jeyraj; Abd Rahim, Nasrudin;
Sandoghchi, Seyed Reza; Adikan, Faisal
Rafiq Mahamd; A Fiber Bragg Grating-Bimetal
Temperature Sensor for Solar Panel Inverters;
SENSORS, Vol. 11, Issue 9, pp. 8665 8673,
September 2011 (ISI-Cited Publication)
8
Hassan, M. R. A.; Tamchek, N.; Abas, A. F.;
Johar, R. M.; Adikan, F. R. Mahamd, ‘Dual-phase
sensing for early detection of prepreg structural
failures via etched cladding Bragg grating’,
SENSORS AND ACTUATORS A- PHYSICAL, Vol.
171, Issue 2, pp. 126-130, NOV 2011 (ISI-Cited
Publication)
9
Siew Woh Choo and Steve Russell. Genomic
approaches to understanding Hox gene function.
Advances in Genetics 2011.76:55-91.
10 Xin Yue Chan, Kek Heng Chua, Savithri D.
Puthucheary, Wai-Fong Yin and Kok-Gan
Chan. Draft Genome Sequence of a Clinical
Isolate Aeromonas sp. Strain 159 Which Shows
Quorum Sensing Activity. J. Bacteriol. November
2012.194:6350; doi:10.1128/JB.01642-12
11 Teik Min Chong, Wai-Fong Yin, Samuel
Mondy, Catherine Grandcl nt, Yves Dessaux,
Kok-Gan Chan. Heavy Metal Resistance of a
France Vineyard Soil Bacterium Pseudomonas
mendocina Strain S5.2 Revealed by Whole
Genome Sequence. J. Bacteriol. November 2012
194:6366; doi:10.1128/JB.01702-12
12 Chien-Yi Chang, Chong-Lek Koh, Choon-Kook
Sam, Xin-Yue Chan, Wai Fong Yin, and Kok Gan
Chan. Unusual Long- Chain N-Acyl Homoserine
Lactone Production by and Presence of Quorum
Quenching Activity in Bacterial Isolates from
Diseased Tilapia Fish. PLoS ONE 7(8), Aug 29,
2012: e44034. doi:10.1371/journal.pone.0044034
13 Kar-Wai Hong, Han-Ming Gan, Siew-Moon
Low, Patrick Kok Yuen Lee, Yee-Meng
Chong, Wai-Fong Yin, Kok-Gan Chan. Draft
Genome Sequence of Pantoea sp. Strain A4, a
Rafflesia-Associated Bacterium That Produces
N-Acylhomoserine Lactones as Quorum-Sensing
Molecules J. Bacteriol. December 2012 vol. 194
no. 23 6610, doi: 10.1128/JB.01619-12
14 Cheng-Siang Wong, Wai-Fong Yin, Yeun-Mun
Choo, Choon- Kook Sam, Chong-Lek Koh
and Kok-Gan Chan. Coexistence of quorum
quenching and quorum sensing in tropical marine
Pseudomonas aeruginosa strain MW3A. World J
of Microbiol & Biotechn Vol 28 (2), 2012: 453-461
15 Wai-Fong Yin, Kathiravan Purmal, Shenyang
Chin, Xin- Yue Chan and Kok-Gan Chan. Long
chain N-acyl homoserine lactone production by
Enterobacter sp. isolated from human tongue
surface. Sensors 2012, 12(11), 14307-14314;
doi:10.3390/s121114307
16 Thiba Krishnan, Wai-Fong Yin and Kok-Gan
Chan. Inhibition of Quorum Sensing-Controlled
Virulence Factor Production in Pseudomonas
aeruginosa PAO1 by Ayurveda Spice Clove
(Syzygium Aromaticum) Bud Extract. Sensors
2012, 12(4), 4016-4030; doi:10.3390/s120404016
17 Wai-Fong Yin, Kathiravan Purmal, Shenyang
Chin, Xin- Yue Chan and Kok-Gan Chan. Long
chain N-acyl homoserine lactone production by
Enterobacter sp. isolated from human tongue
surface. Sensors 2012, 12(11), 14307-14314;
doi:10.3390/s121114307
18 Kar-Wai Hong, Chong-Lek Koh, Choon-Kook
Sam, Wai-Fong Yin and Kok-Gan Chan. Quorum
Quenching Revisited From Signal Decays to
Signalling Confusion. Sensors 2012, 12(4), 46614696; doi:10.3390/s120404661
49
50
High Impact Research Annual Report 2012
19 Teik-Min Chong, Chong-Lek Koh, Choon-Kook
Sam, Yeun- Mun Choo, Wai-Fong Yin and
Kok-Gan Chan. Characterization of Quorum
Sensing and Quorum Quenching Soil Bacteria
Isolated from Malaysian Tropical Montane Forest.
Sensors 2012, 12(4), 4846- 4859; doi:10.3390/
s120404846
20 Li Ying Tan, Wai-Fong Yin and Kok-Gan Chan.
Silencing Quorum Sensing through Extracts of
Melicope lunu-ankenda. Sensors 2012, 12(4),
4339-4351; doi:10.3390/s120404339
21 Wai-Fong Yin, Kathiravan Purmal, Shenyang
Chin, Xin-Yue Chan, Chong-Lek Koh,
Choon-Kook Sam and Kok-Gan Chan. 2012.
N-acyl homoserine lactone production by
Klebsiella pneumoniae isolated from human
tongue surface. 2012. Sensors. doi:10.3390/
s120x0000x
22 Patrick Kok Yuen Lee, Swee Yee Ng, Dennis
Yong, Xue Ching Chai, Wai Fong Yin, and
Kok Gan Chan. 2012. Molecular phylogeny
characterisation of Malaysian fighting fish Betta
pi (Teleostei: Osphronemidae) based on its 18S
ribosomal DNA sequences Asia Life Sciences.
21(1): 57-64.
23 Cheng-Siang Wong, Wai-Fong Yin, ChoonKook Sam, Chong- Lek Koh, Kok-Gan Chan.
Characterisation of Malaysian wetland quorum
quenching Pseudomonas aeruginosa strain
2SW8 and its 2-heptyl-3-hydroxy-4-quinolone
production. New Microbiologica, 35, 43-51,
2012.
24 Selva Perumal Gunaletchumy, Xinsheng Teh,
Yalda Khosravi, Nur Siti Khadijah Ramli, Eng
Guan Chua, Thevakumar Kavitha, Joanne N.
Mason, Huey Tyng Lee, Halimah Alias, Nur Zafirah
Zaidan, Norzawani Buang M. Yassin, Liang Chung
Tay, Stephen Rudd, Hazel M.Mitchell, Nadeem O.
Kaakoush, Mun Fai Loke, Khean Lee Goh, and
Jamuna Vadivelu (2012) Draft genome sequences
of Helicobacter pylori isolates from Malaysia,
cultured from patients with functional dyspepsia
and gastric cancer. J Bacteriol 194(20):5695. DOI:
10.1128/JB.01278-12.
25 Kumar N, Mukhopadhyay AK, Patra R, De R,
Baddam R, Shaik S, Alam J, Tiruvayipati S,
Ahmed N. Next-generation sequencing and
de novo assembly, genome organization, and
comparative genomic analyses of the genomes
of two Helicobacter pylori isolates from duodenal
ulcer patients in India. J Bacteriol. 2012
Nov;194(21):5963-4.
26 Ea CK, Hao S, Yeo KS, Baltimore D. 2012.
EHMT1 Protein Binds to Nuclear Factor-kappaB
p50 and Represses Gene Expression. J Biol
Chem 287: 31207-31217. PMID:22801426
27 S. Vijay Kumar, N.M. Huang, H.N. Lim, A.R.
Marlinda, I. Harrison, C.H. Chia. One-step
size-controlled synthesis of functional graphene
oxide/silver nanocomposite at room temperature.
Chemical Engineering Journal (2012), doi: http://
dx.doi.org/10.1016/j. cej.2012.09.063
28 Kok Siong Yeo, Taznim Begam Mohd Mohidin,
Ching Ching Ng. 2012. EBV-encoded LMP-1
upregulates 14-3-3σ and Reprimo to confer
G2/M phase Cell Cycle Arrest. Comptes rendus Biologies 335 (2012), pp. 713-721
29 Jian-Woon Chen, Han Ming Gan, Wai-Fong
Yin, Kok-Gan Chan.Genome Sequence of
Roseomonas sp. Strain B5, a Quorum-quenching
N-Acylhomoserine Lactones-Degrading
Bacterium Isolated from Malaysian Tropical Soil.
J. Bacteriol. December 2012 vol. 194 no. 23
6681-6682; doi: 10.1128/JB.01866-12
30 Nida Iqbal, Mohammed Rafiq Abdul Kadir,
Nik Ahmad Nizam Nik Malek ,Nasrul Humaimi
Mahmooda, Malliga Raman Murali, Tunku
Kamarul. Rapid microwave assisted synthesis
and characterization of nanosized silver-doped
hydroxyapatite with antibacterial properties.
Materials Letters 89 (2012) 118–122.
31 Chong, P.-P., Selvaratnam, L., Abbas, A. A. and
Kamarul T. (2012), Human peripheral blood
derived mesenchymal stem cells demonstrate
similar characteristics and chondrogenic
differentiation potential to bone marrow derived
mesenchymal stem cells. J. Orthop. Res., 30:
634 642. doi: 10.1002/jor.21556
32 Tan SL, Ahmad RE, Ahmad TS, Merican AM,
Abbas AA, Ng WM, Kamarul T. Effect of Growth
Differentiation Factor 5 on the Proliferation and
Tenogenic Differentiation Potential of Human
Mesenchymal Stem Cells in vitro. Cells Tissues
Organs. 2012 May 30. [Epub ahead of print] (ISICited Publication)
33 Ab-Rahim S, Selvaratnam L, Raghavendran
HR, Kamarul T. 2012. Chondrocyte-alginate
constructs with or without TGF-β1 produces
superior extracellular matrix expression than
monolayer cultures. Molecular and Cellular
Biochemistry
34 Latifi H, Rukmanikanthan S, Mansor A, Kamarul
T, Bilgen M. Prospects of implant with locking
plate in fixation of subtrochanteric fracture:
experimental demonstration of its potential
benefits on synthetic femur model with
supportive hierarchical nonlinear hyperelastic
finite element analysis.Biomed Eng Online. 2012
Apr 30;11(1):23. [Epub ahead of print]. (ISI-Cited
Publication)
35 Jian-Woon Chen and Kok-Gan Chan. Genome
Sequence of Dyella japonica Strain A8, a
Quorum-Quenching Bacterium That Degrades
N-Acylhomoserine Lactones, Isolated from
Malaysian Tropical Soil. J. Bacteriol. November
2012 vol. 194 no. 22 6331. doi: 10.1128/
JB.01637-12
36 Kar-Wai Hong, Chong-Lek Koh, Choon-Kook
Sam, Wai-Fong Yin, Kok-Gan Chan. Complete
Genome Sequence of Burkholderia sp. Strain
GG4, a Betaproteobacterium That Reduces
3-oxo-N-acylhomoserine Lactones and Produces
Different N-acylhomoserine Lactones.J.
Bacteriol. November 2012 vol. 194 no. 22 6317.
doi: 10.1128/JB.01578-12
37 Noraini Ahmad, Roland Ramsch, Jordi Esquena,
Conxita Solans, Hairul Anuar Tajuddin, Rauzah
Hashim. Physico-Chemical Characterization
High Impact Research Annual Report 2012
of Natural-Like Branched-Chain Glycosides
towards Formation of Hexosomes and Vesicles.
Langmuir, 2012, 28 (5), 2395 2403.
38 Kar-Wai Hong, Chong-Lek Koh, Choon-Kook
Sam, Wai-Fong Yin, Kok-Gan Chan. Whole
Genome Sequence of N-acylhomoserine Lactone
Synthesizing and Degrading Acinetobacter sp.
Strain GG2. J. Bacteriol. November 2012 vol. 194
no. 22 6318. doi: 10.1128/JB.01579-12
39 Kar Wai Hong, Dinaiz a/l Thinagaran, Han Ming
Gan, Wai- Fong Yin, Kok-Gan Chan. Whole
genome sequencing of Cupriavidus sp. strain
BIS7: a heavy metal resistant bacterium. J.
Bacteriol. November 2012 vol. 194 no. 22 6324.
doi: 10.1128/JB.01608-12
40 Soon Wei Chook1, Chin Hua Chia1*, Sarani
Zakaria1, Mohd Khan Ayob2, Kah Leong
Chee2, Nay Ming Huang3, Hui Min Neoh4,
Hong Ngee Lim5. Antibacterial Performance of
Ag Nanoparticles and AgGO nanocomposites
prepared via rapid microwave-assisted synthesis
method. Nanoscale Research Letters 2012,
7:541
41 BhooPathy N, Uiterwaal CS, Taib NA,Verkooijen
HM, Yip CH. Gradually implemented new
biomarkers for prognostication of breast cancer:
complete case analysis may introduce bias. J
ClinEpidemiol. 2012;65(5):568-71.
42 BhooPathy N, Hartman M, Yip C, Saxena N,
Taib NA, SiewEng Lim SE, Philip Iau P, HansOlovAdami, Bulgiba AM, Lee SC, Verkooijen
HM. Ethnic differences in survival after breast
cancer in South East Asia. PLOS One. 2012;
7(2):e30995 (Tier 1 IF 4.4)
43 Bhoo-Pathy N, Yip CH, Hartman M, Saxena
N, Taib NA, Ho GF, Looi LM, Bulgiba AM, van
der Graaf Y, Verkooijen HM. Adjuvant! Online
is overoptimistic in predicting survival of Asian
breast cancer patients. Eur J Cancer. 2012;
48(7):982-9. (Tier 1 IF 4.8)
44 CheeEePhua, Anita ZarinaBustam,
MasturaMdYusof, MarnizaSaad, Cheng-Har Yip,
Taib NA and Char Hong Ng. Risk of treatment
related death (TRD) with adjuvant chemotherapy
for breast cancer: A study in University Malaya
Medical Centre (UMMC). Journal of Cancer
Therapeutics & Research. 2012; 1(13).
45 Dahlui M, Gan DE, Taib NA, Pritam R, Lim J.
Predictors of Breast Cancer Screening uptake: A
pre-intervention community survey in Malaysia.
Asian Pac J Cancer Prev. 2012; 13(7): 3443-9.
46 Mujar M, Dahlui M, Yip CH, Taib NA. Delays in
time to primary treatment after a diagnosis of
breast cancer: Does it impact survival? Prev
Med. 2012 Dec 9
47 Daphne SC Lee, Sook-Yee Yoon, Lai MengLooi,
Peter Kang, In Nee Kang, KavittaSivanandan,
HanyAriffin, Meow Keong Thong, Kin Fah Chin,
Taib NA,Cheng-Har Yip and Soo-Hwang Teo.
Novel germline TP53 mutations from a multiethnic Asian cohort of early-onset breast cancer
patients in Malaysia. Breast Cancer Research.
2012; 14:R66
48 Lee DS, Yoon SY, Looi LM, Kang P, Kang IN,
Sivanandan K, Ariffin H, Thong MK, Chin KF, Taib
NA, Yip CH, Teo SH. Comparable frequency of
BRCA1, BRCA2 and TP53 germline mutations
in a multi-ethnic Asian cohort suggests TP53
screening should be offered together with
BRCA1/2 screening to early-onset breast cancer
patients.Breast Cancer Res. 2012; 14(2):R66.
49 Naidu R, Yip CH, Taib NA. Genetic variations
in transciption factor 7-like 2 (TCF7L2) gene:
association of TCF7L2 rs12255372 (G/T) or
rs7903146(C/T) with breast cancer risk and
clinico-pathological parameters. Med Oncol.
2012; 29(2):411-7.
50 NakulSaxena, Mikael Hartman, NirmalaBhooPathy, Jennifer N. W. Lim, Tar-Ching Aw, Philip
Iau, NurAishahTaib, Soo-Chin Lee, Cheng-Har
Yip, Helena M. Verkooijen. Breast Cancer in
South East Asia: Comparison of Presentation
and Outcome Between a Middle Income and a
High Income Country. World J Surg. 2012.
51 Ng CH, Pathy NB, Taib NA,Mun KS, Rhodes
A, Yip CH. The estrogen receptor negativeprogesterone receptor positive breast carcinoma
is a biological entity and not a technical artifact.
Asian Pac J Cancer Prev. 2012; 13(4):1111-3.
52 Phuah SY, Looi LM, Hassan N, Rhodes A, Dean
S, Taib NA, Yip CH, Teo SH. Triple-negative
breast cancer and PTEN (phosphatase and
tensin homologue)loss are predictors of BRCA1
germline mutations in women with early-onset
and familial breast cancer, but not in women with
isolated late-onset breast cancer.Breast Cancer
Res. 2012 Nov 2;14(6):R142
53 N BhooPathy, CH Yip, M Hartman, CSP
Uiterwaal, BCR Devi, PHM Peeters, NA Taib, CH
van Gils, HM Verkooijen. Breast cancer research
in Asia: Adopt or adapt Western knowledge?
European J Cancer. 2012.
54 Ng KH, Yip CH and Taib NA.Breast density
speaks volumes - an argument for the
standardisation of clinical breast density
measurement based on 3D data. Lancet Oncol.
2012;13(4):334-6. (Tier 1)
55 Saxena N, Hartman M, Yip CH, Bhoo-Pathy N,
Khin LW, Taib NA, Looi LM, Lim SE, Lee SC,
Verkooijen HM. Does the Axillary Lymph Node
Ratio Have Any Added Prognostic Value over
pNStaging for South East Asian Breast Cancer
Patients?PLoS One. 2012; 7(9):e45809.
56 Saxena N, Hartman M, Bhoo-Pathy N, Lim JN,
Aw TC, Iau P,Taib NA, Lee SC, Yip CH,Verkooijen
HM. Breast Cancer in South East Asia:
Comparison of Presentation and Outcome
Between a Middle Income and a High Income
Country.World J Surg. 2012
57 Yip CH, Taib NA. Challenges in the management
of breast cancer in low- and middle-income
countries.Future Oncol. 2012 Dec;8(12).
58 Sarmani, AR; Abu Bakar, MH; Adikan, FRM;
Mahdi, MA, ‘Laser Parameter Variations in a
Rayleigh Scattering- Based Raman Fiber Laser
With Single Fiber Bragg Grating Reflector’,
IEEE PHOTONICS JOURNAL Volume: 4
51
52
High Impact Research Annual Report 2012
Issue: 2 Pages: 461-466 DOI: 10.1109/
JPHOT.2012.2190925 Published: APR 2012 (ISICited Publication)
59 Abu Bakar, MH; Adikan, FRM; Mahdi, MA,
‘Rayleigh-based Raman fiber laser with passive
erbium-doped fiber for secondary pumping effect
in remote L-band erbium-doped fiber amplifier,’
IEEE Photonics Journal, Vol. 4, No. 3, pp. 10421050, June 2012 (ISI-Cited Publication)
60 Y. G. Shee, M. H. Al-Mansoori, S. Yaakob, A.
Man, A. K. Zamzuri, F. R. M. Adikan, and M. A.
Mahdi, “Millimeter wave carrier generation based
on a double-Brillouin- frequency spaced fiber
laser,” Optics Express, vol. 20, pp. 13402-13408,
2012 (ISI-Cited Publication)
61 D. C. Tee, T. Kambayashi, S. R. Sandoghchi,
N. Tamchek, F. R. Mahamd Adikan, ‘Efficient,
wide angle, structure tuned 1x3 photonic
crystal power splitter at 1550nm for triple play
applications’, Journal of Lightwave Technology,
Vol. 30, No. 17, pp. 2870-2875, Sept. 2012 (ISICited Publication)
62 Hisham, H.K., Mahdiraji, G.A., Abas, A.F., Mahdi,
M.A., Adikan, F.R.M., ‘Characterization of TurnOn Time Delay in a Fiber Grating Fabry-Perot
Laser’, IEEE Photonics Journal, Vol. 4, No. 5, pp.
1662-1678, Oct. 2012 (ISI-Cited Publication)
63 Hassan, Muhammad R.A.; Bakar, Muhammad
H.A.; Dambul, Katrina; Adikan, Faisal R.M. 2012.
“Optical-Based Sensors for Monitoring Corrosion
of Reinforcement Rebar via an Etched Cladding
Bragg Grating.” Sensors 12, no. 11: 1582015826.
64 Sumiaty Ambran, Christopher Holmes, James
C. Gates, Andrew S. Webb, Lewis G. Carpenter,
Faisal R. Mahamd Adikan, Peter G. R. Smith, and
Jayanta K. Sahu, ‘Fabrication of a Multimode
Interference Device in a Low Loss Flat-fiber
Platform using Physical Micromachining
Technique’, IEEE Journal of Lightwave
Technology (accepted for publication 2012);(ISICited Publication)
65 Adikan, F.R.M.; Sandoghchi, S.R.; Chong Wu Yi;
Simpson, R.E.; Mahdi, M.A.; Webb, A.S.; Gates,
J.C.; Holmes, C.; , “Direct UV Written Optical
Waveguides in Flexible Glass Flat Fiber Chips,”
Selected Topics in Quantum Electronics, IEEE
Journal of , vol.18, no.5, pp.1534-1539, Sept.Oct. 2012
66 Ghomeishi, Mostafa; Karami, Mohammad;
Adikan, Faisal Rafiq Mahamd; , “Developing
small vacuum spark as an x-ray source
for calibration of an x-ray focusing crystal
spectrometer,” Review of Scientific Instruments ,
vol.83, no.10, pp.103110-103110-5, Oct 2012
67 Al-Fakih, E.; Abu Osman, N.A.; Mahamd Adikan,
F.R. “The Use of Fiber Bragg Grating Sensors in
Biomechanics and Rehabilitation Applications:
The State-of-the-Art and Ongoing Research
Topics.” Sensors 2012, 12, 12890-12926.
68 Siew Woh Choo,Yan Ling Wong,Mee Lian
Leong,Hamed Heydari,Chia Sui Ong,Kee
Peng Ng,and Yun Fong Ngeow. Analysis of the
genome of Mycobacterium abscessus strain M94
reveals an uncommon cluster of tRNAs. Journal
of Bacteriology.2012 Oct;194(20):5724
69 Siew Woh Choo,Aini Mohamed Yusoff,Yan Ling
Wong,Wei Yee Wee,Chia Sui Ong,Kee Peng
Ng,and Yun Fong Ngeow. Genome Analysis
of Mycobacterium massiliense strain M172
with a putative mycobacteriophage. 2012
Sep;194(18):5128. doi: 10.1128/JB.01096-12
70 Siew Woh Choo,Yan Ling Wong, Joon Liang
Tan, Chia Sui Ong, Kee Peng Ng and Yun
Fong Ngeow. Draft Genome Sequence of
Mycobacterium bolletii Strain M24, a rapidly
growing mycobacterium of contentious
taxonomic status. Journal of Bacteriology. J.
Bacteriol. 2012 Aug;194:4475.
71 Siew Woh Choo, Yan Ling Wong,Aini
Mohamed Yusoff,Mee Lian Leong,Guat Jah
Wong,Chia Sui Ong,Kee Peng Ng and Yun
Fong Ngeow. Genome Sequence of the
Mycobacterium abscessus Strain M93. Journal
of Bacteriology.2012 Jun; 194(12):3278.
72 Siew Woh Choo,Yan Ling Wong,Joon Liang
Tan,Chia Sui Ong, Guat Jah Wong,Kee Peng
Ng,and Yun Fong Ngeow. Annotated genome
sequence of Mycobacterium massiliense
strain M154, belonging to the recently created
taxon,Mycobacterium abscessus subspecies
bolletii comb. Nov Journal of Bacteriology. 2012
Sep;194(17):4778. doi: 10.1128/JB.01043-12.
73 Yun Fong Ngeow, Yan Ling Wong, Joon Liang
Tan, Ramitha Arumugam, Guat Jah Wong,
Chia Sui Ong, Kee Peng Ng and Siew Woh
Choo. Genome Sequence of Mycobacterium
massiliense M18 isolated from a lymph node
biopsy. J. Bacteriol. 2012 Aug ;194:4125.
74 Yun Fong Ngeow,Yan Ling Wong,Naline
Lokanathan,Guat Jah Wong,Chia Sui Ong,Kee
Peng Ng, and Siew Woh Choo. Genomic
analysis of Mycobacterium massiliense strain
M115, an isolate from human sputum. 2012
Sep;194(17):4786. doi: 10.1128/JB.01104-12.
75 Yun Fong Ngeow, Wei Yee Wee, Yan Ling
Wong, Joon Liang Tan, Chia Sui Ong, Kee Peng
Ng, and Siew Woh Choo.Genomic analysis of
Mycobacterium abscessus strain M139 with
an ambiguous subspecies taxonomic position.
Journal of Bacteriology.2012 Nov;194(21):60023. doi: 10.1128/JB.01455-12.
76 Yun Fong Ngeow, Yan Ling Wong, Joon Liang
Tan, Chia Sui Ong, Kee Peng Ng and Siew Woh
Choo. Genome Sequence of the Mycobacterium
abscessus strain M152. Journal of Bacteriology.
2012 Dec;194 (23): 6662
HIR 2 YEARS PROJECT 2010
1
Appanna R,Ponnampalvanar S, Lum LCS,
Sekaran SD. Susceptible and protective HLA
class 1 alleles against dengue fever and dengue
hemorrhagic fever patients in a Malaysian
population. PloS ONE (2010)5(9):e13029.
doi:10.1371/journal.pone.0013029
High Impact Research Annual Report 2012
2
Ayu SM, Lai LR, Chan YF, Hatim A, Hairi NN,
Ayob A , Sam IC. Seroprevalence survey of
Chikungunya virus in Bagan Panchor, Malaysia.
Am J. Trop Med Hyg. 2010 Dec;83(6):1245-8.
3
Wee, C. Y., & Raveendran Paramesran,(2010).
Image Quality Assessment by Discrete
Orthogonal Moments, Pattern Recognition.
Vol.43, No.12, pp 4055-4068.
4
Zheng-Ming, Chuah ,Raveendran Paramesran,
Kavintheran, Thambiratnam , Sin-Chew, Poh,
(2010). A two-level partial least squares system
for non-invasive blood glucose concentration
prediction, Chemometrics and Intelligent
Laboratory Systems. Vol. 104, No.2, pp 347-351.
5
Alhoot MA, Wang SM, Sekaran SD. Inhibition
of Dengue Virus Entry and Multiplication into
Monocytes Using RNA Interference. PloS Negi
Trop Dis (2011) 5 (11):e1410.doi:10.1371/journal.
pntd.0001410
6
Chan YF, Sam IC, Wee KL, AbuBakar S. (2011).
Enterovirus 71 in Malaysia: A decade later.
Neurology Asia 16: 1 – 15.
7
Huang, N.M., Lim, H.N., Chia, C.H., Yarmo,
M.A. and Muhamad, M.R. 2011. Simple roomtemperature preparation of high-yield largearea graphene oxide. International Journal of
Nanomedicine 6: 3443-3448.
8
Urawa S, Freeman MA, Johnson SC, Jones
SRM, Yokoyama H. Geographical variation in
spore morphology, gene sequences and host
specificity of Myxobolus arcticus (Myxozoa)
infecting salmonid nerve tissues. Dis. Aquat. Org.
2011 Oct;96:229-237
9
Sam IC, Chua CL, Chan YF. Chikungunya virus
diagnosis in the developing world: a pressing
need. Expert Review of Anti-Infective Therapy
2011; 9: 1089-1091.
10 Nazir R, Mazhar M, Wakeel T, Akhtar MJ,
Siddique M, Nadeem M, Khan NA, Shah R.
Pyrolysis Mechanism of Trisbipyridineiron(II)
Chloride to Iron Nanoparticles. J. Therm Anal
Calorim (2011) DOI:10.1007/s10973-011-1919-5
11 Nazir R, Mazhar M, Wakeel T, Akhtar MJ,
Siddique M, Nadeem M, Khan NA, Shah R.
Pyrolysis Mechanism of Trisbipyridineiron(II)
Chloride to Iron Nanoparticles. J. Therm Anal
Calorim (2011) DOI:10.1007/s10973-011-1919-5.
12 Chern-Loon Lim, Barmark Honarvar, Kim Han
Thung, Raveendran Paramesran,(2011). Fast
computation of exact Zernike moments using
cascaded digital filters. Journal Information
Sciences, Vol. 181, No.17, pp 3638-3651.
13 Lim, C.K. and Chan, C.S. Logical Connectives
and Operativeness of BK Sub-triangle Product in
Fuzzy Inferencing, International Journal of Fuzzy
Systems. 2011: 13(4):237-245
14 Razali R, Zak AK, Abd Majid WH, Darroudi M,
Solvothermal synthesis of microsphere ZnO
nanostructures in DEA media, Ceram Int. 2011
Dec; 37: 3657-3663.
15 Romano Ngui, Saidon Ishak, Chow Sek
Chuen, Rohela Mahmud & Yvonne Lim Ai Lian
(2011). Prevalence and risk factors of intestinal
parasitism in rural and remote West Malaysia.
Plos NTD 5 (3): e974.
16 Romano Ngui, Yvonne A. L. Lim, Noor Farahani
Amir,Veeranoot Nissapatorn and Rohela
Mahmud (2011). Seroprevalence and sources of
toxoplasmosis among Orang Asli (Indigenous)
Communities in Peninsular Malaysia. American
Journal of Tropical Medicine and Hygiene 85(4):
660-666.
17 Zak AK, Razali R, Abd Majid WH, Darroudi M,
Synthesis and characterization of narrow size
distribution of zinc oxide nanoparticles. Int. J.
Nanomed. 2011 Jul; 6: 1399–1403.
18 Zak AK, Gan WC, Abd Majid WH, Darroudi M,
Experimental and Theoretical Dielectric Studies
of PVDF/PZT Nanocomposite Thin Films. Ceram
Int. 2011 Jul; 37: 1653-1660
19 Velayutham TS, Abd Majid WH, Ahmad AB, Gan
SN, Electrical behaviour of polyurethane derived
from polyols synthesized with glycerol, phthalic
anhydride and oleic acid. J. Appl. Polym. Sci.
2011 Aug; 121: 1796-1803.
20 Zak AK, Abd Majid WH, Effect of solvent
on structure and optical properties of PZT
nanoparticles prepared by sol–gel method, in
infrared region. Ceram Int. 2011 Apr; 37: 753-758.
21 Zak AK, Abd Majid WH, Abrishami ME, Yousefi R,
Hosseini SM, X-ray analysis of ZnO nanoparticles
by Williamson–Hall and size–strain plot methods.
Solid State Sci. 2011 Jan; 13: 251-256
22 Zak AK, Abd Majid WH, Abrishami ME, Yousefi
R, Hosseini SM, Effects of annealing temperature
on some structural and optical properties of ZnO
nanoparticles prepared by a modified sol–gel
combustion method. Ceram Int. 2011 Jan; 37(1):
393-398.
23 Zak AK, Abd Majid WH, Darroudi M, Yousefi
R, Synthesis and characterization of ZnO
nanoparticles prepared in gelatin media. Mater.
Lett. 2011 Jan; 65(1): 70-73.
24 Tan CW, Chan YF, Sim KM, Tan EL, Poh CL.
(2012). Inhibition of Enterovirus 71 (EV-71)
Infections by a Novel Antiviral Peptide derived
from EV-71 Capsid Protein VP1. PLOS One. 7:5.
25 Sam IC, Loong SK, Michael JC, Chua CL, Wan
Sulaiman WY, Vythilingam I, Chan SY, Chiam CW,
Yeong YS, AbuBakar S, Chan YF. Genotypic and
phenotypic characterization of Chikungunya virus
of different genotypes from Malaysia. PLoS One
2012; 7: e50476.
26 Rubio-Godoy M, Paladini G, Freeman MA,
García-Vásquez A, Shinn AP. Morphological
and molecular characterisation of Gyrodactylus
salmonis (Platyhelminthes, Monogenea) collected
in Mexico from rainbow trout (Oncorhynchus
mykiss Walbaum). Vet. Parasitol. 2012
May;186(3-4):289-300
27 Caruana S, Yoon GH, Freeman MA, Mackie JA,
Shinn AP. The efficacy of selected plant extracts
and bioflavonoids in controlling infections
of Saprolegnia australis (Saprolegniales;
Oomycetes). Aquaculture 2012 Aug;358359:146–154.
53
54
High Impact Research Annual Report 2012
28 Vijay Kumar, S., Huang, N.M., N. Yusoff, Lim,
H.N., 2012. High Performance Magnetically
Separable Graphene/Zinc Oxide Nanocomposite.
Materials Letters. Accepted.
39 P.S. Lim, H. N. Lim, N. M. Huang, C. H. Chia,
I. Harrison. 2012. Room temperature in situ
synthesis of Fe3O4/graphene nanocomposites.
Ceramics International. 38: 6411-6416.
29 Appanna R, Wang SM,Ponnampalavanar SA,
Lum LCS, Sekaran SD. Cytokine Factors Present
in Dengue Patient Sera Induces Alterations of
Junctional Proteins in Human Endothelial Cells.
AM J Trop Med Hyg (2012) 87:936-942
40 B.Y.S. Chang, N.M. Huang, M.N. An’ amt, M.A.
Rahman, N. Yusoff, M.R. Muhamad, I. Harrison,
C. H. Chia. 2012. Facile hydrothermal preparation
of titanium dioxide decorated reduced graphene
oxide nanocomposite. International Journal of
Nanomedicine. 2012(7):1-9.
30 Arof, A.K., Kufian, M.Z., Syukur, M.F., Aziz,
M.F., Abdelrahman, A.E., Majid, S.R, Electrical
double layer capacitor using poly(methyl
methacrylate)-C 4BO 8Li gel polymer electrolyte
and carbonaceous material from shells of mata
kucing (Dimocarpus longan) fruit, Electrochimica
Acta 74 (2012) pp. 39-45
31 Rathakrishnan A, Wang SM, Hu Y, Khan AM,
Ponnampalavanar S, Lum LCS, Manikam R,
Sekaran SD. Cytokine Expression Profile of
Dengue Patients at Different Phases of Illness.
PloS ONE (2012) 7(12);e52215. doi: 10.1371/
journal.pone.0052215
32 Zurina Osman, Siti Mariam Samin, Lisani Othman
and Khairul Bahiyah Md Isa, “Ionic Transport in
PMMA-NaCF3SO3 Gel Polymer Electrolytes”,
Advanced Materials Research, 545(2012), 259263.
33 Z.Osman, M.I. Mohd Ghazali, L. Othman,
K.B. Md Isa, “AC ionic conductivity and DC
polarization method of lithium ion transport in
PMMA–LiBF4 gel polymer electrolytes, Results in
Physics, 2(2012), 1-4.
34 Chong CE, Lim KP, Gan CP, Marsh CA, Zain RB,
Abraham MT, Prime SS, Teo SH, Silvio Gutkind
J, Patel V, Cheong SC. Over-expression of
MAGED4B increases cell migration and growth in
oral squamous cell carcinoma and is associated
with poor disease outcome. Cancer Lett. 2012
Aug;321(1):18-26 (Tier 1, Impact factor-4.238)
35 Golsheikh, A.M., Huang, N.M., Lim, H.N.,
Chia, C.H., Harrison, I. and Muhamad, M.R.
2012. One-pot hydrothermal synthesis and
characterization of FeS2 (pyrite)/graphene
nanocomposite. Chemical Engineering Journal
Accepted.
36 Vijay Kumar, S., Huang, N.M., Lim, H.N.,
Marlinda, A.R., Harrison, I. and Chia, C.H. 2012.
One-step size-controlled synthesis of functional
graphene oxide/silver nanocomposite at room
temperature. Chemical Engineering Journal
Accepted.
37 Chook, S.W. C.H. Chia, S. Zakaria, M.K. Ayob,
K.L. Chee, N.M. Huang, H.M. Neoh, H.N. Lim, R.
Jamal, R.M.F.R.A. Rahman. 2012. Antibacterial
Performance of Ag Nanoparticles and AgGO
nanocomposites prepared via rapid microwaveassisted synthesis method. Nanoscale Research
Letter. 7: 541.
38 Zainy, M., Huang, N.M., Vijay Kumar, S. and Lim,
H.N. 2012. Simple and scalable preparation of
reduced graphene oxide-silver nanocomposites
via rapid thermal treatment. Materials Letters 89:
180-183.
41 Vincent-Chong VK, Ismail SM, Rahman ZA,
Sharifah NA, Anwar A, Pradeep PJ, Ramanathan
A, Karen-Ng LP, Kallarakkal TG, Mustafa WM,
Abraham MT, Tay KK, Zain RB. Genome-wide
analysis of oral squamous cell carcinomas
revealed over expression of ISG15, Nestin and
WNT11. Oral Dis. 2012 Jul;18(5):469-76. (Tier 1,
Impact factor- 2.495)
42 M.A. Rahman, N. Yusoff, M.R. Muhamad, I.
Harrison, M.N. An’ amt, B.Y.S. Chang, N. M.
Huang. 2012. Highly efficient preparation of
ZnO/reduced graphene oxide nanocomposites.
Materials Letters 80:9-12
43 Lim, H.N., Huang, N.M. and Loo, C.H. 2012.
Facile preparation of graphene-based chitosan
films: Enhanced thermal, mechanical and
antibacterial properties. Journal of NonCrystalline Solids 358: 525-530.
44 Alhoot MA, Wang SM, Sekaran SD. RNA
Interference Mediated Inhibition of Dengue Virus
Multiplication and Entry in HepG2 Cells. PloS
ONE (2012) 7(3):e34060.doi:10.1371/journal.
pone.0034060
45 Vincent-Chong VK, Anwar A, Karen-Ng LP,
Cheong SC, Yang Y-H, Pradeep PJ, Rahman
ZAA, Ismail SM, Zaini ZM, Prepageran N,
Kallarakkal TG, Ramanathan A, Mohayadi
NABM, Rosli NSBM, Mustafa WMW, Mannil
TA, Tay KK, Zain RB. Genome Wide Analysis of
Chromosomal Alterations in Oral Squamous Cell
Carcinomas Revealed Over Expression of MGAM
and ADAM9. PloS One (2012) (Accepted) (Tier 1,
Impact factor-4.092)
46 Zanaruddin SN, Saleh A, Yang YH, Hamid
S, Mustafa WM, Khairul Bariah AA, Zain RB,
Lau SH, Cheong SC. Four-protein signature
accurately predicts lymph node metastasis and
survival in oral squamous cell carcinoma. Hum
Pathol. 2012 [Epub ahead of print] (Tier 2, Impact
factor- 2.876)
47 Tan CW, Poh CL, Sam IC, Chan YF (2012).
Enterovirus 71 uses cell surface heparan sulfate
glycosaminoglycan as an attachment receptor.
Journal of Virology 87-611-620.
48 Kah-Hyong Chang; Raveendran Paramesran,
Senior Member, IEEE; Barmak Honarvar
Shakibaei Asli; Chern-Loon Lim, (2012) “Efficient
Hardware Accelerators for the Computation
of Tchebichef Moments”,IEEE Transaction on
Circuit, System, and Video Technology. Vol 22,
No. 3, pp 414-425.
49 Kim Han Thung, Raveeendran Paramesran,
and Chern Loon Lim,(2012). Content Based
High Impact Research Annual Report 2012
Image Quality Metric using Similarity Measure
of Moment Vectors, Pattern Recognition. Vol 45,
No.6, pp 2193-2204.
50 Wong LP. Qualitative Inquiry into Premarital
Sexual Behaviours and Contraceptive Use
among Multiethnic Young Women: Implications
for Education and Future Research.PLoS ONE
(2012) 7 (12): e51745. DOI:10.1371/journal.pone.
0051745
51 Wong LP. An exploration of knowledge, attitudes
and behaviours of young multiethnic Muslimmajority society in Malaysia in relation to
reproductive and premarital sexual practices.
BMC Public Health. 2012; 12:865
52 Tan, W.R.; Chan, C.S.; Yogarajah, P. and Condell,
J. A Fusion Approach for Efficient Human Skin
Detection, IEEE Transactions on Industrial
Informatics. 2012; 8(1):138-147.
crosslinking on the properties of palm oil-based
polyurethane coatings. J. Appl. Polym. Sci.
(2012) DOI: 10.1002/app.38768
61 Zak AK, Yousefi R, Abd Majid WH, Muhamad
MR, Facile synthesis and X-ray peak broadening
studies of Zn1-xMgxO nanoparticles. Ceram Int.
2012 Apr; 38: 2059-2064.
62 Zak AK, Abd Majid WH, Mahmoudian MR,
Darroudi M, Yousefi R, Starch-stabilized
synthesis of ZnO nanopowders at low
temperature and optical properties study. Adv.
Powder Technol. (2012) DOI:org/10.1016/j.
apt.2012.11.008
63 Zak AK, Abd Majid WH, Darroudi M, Facile
synthesis and characterization of Lanthanum
(III) Oxychloride nanoparticles in natural polymer
matrix, Mater. Chem. Phys. 2012 Oct; 136 (2-3):
705-709.
53 Chan Y.F., Wee, K.L., Chiam, C.W., Khor, C.S.,
Chan, S.Y., Wan Nor Amalina W.M.Z., Sam, I.C.
(2012). Comparative Genetic Analysis of VP4,
VP1 and 3D Gene Regions of Enterovirus 71
and Coxsackievirus A16 Circulating in Malaysia
between 1997-2008. Tropical Biomedicine 29:
451-466.
64 Zak AK, Abd Majid WH, Abrishami ME, Darroudi
M, Synthesis and X-ray analysis of Zn0.97X0.03O
nanoparticles (X=Mn, Ni, and Co) using Scherrer
and size-strain plot methods. Solid State Sci.
2012 Apr; 14: 488-494.
54 Arafat MM, Dinan B, Akbar SA, Haseeb
ASMA. Gas Sensor Based on One Dimentional
Nanostructured Metal Oxides: A Review. Sensors
(2012) DOI:10.3390/s120607207
HIR 2 YEARS PROJECT 2011
55 Pukana Jayaraman, Prakash Nathan,
Punitha Vasanthan, Sabri Musa, Vijayendran
Govindasamy. Stem cells conditioned medium:
A new approach to skin wound healing
management. Wound Repair and Regeneration.
(Submitted on 20 December 2012).
56 Romano Ngui, Yvonne A.L. Lim, Liam Chong
Kin, Chow Sek Chuen, Shukri Jaffar (2012).
Association between anaemia, iron deficiency
anaemia, neglected parasitic infections and
socioeconomic factors in rural children of West
Malaysia. PLoS Neglected Tropical Diseases 6(3):
e1550. doi:10.1371/journal.pntd.0001550.
57 Romano Ngui, Yvonne A.L. Lim, Rebecca Traub,
Rohela Mahmud, Mohd Sani Mistam (2012).
Epidemiological and genetic data supporting the
transmission of Ancylostoma ceylanicum among
human and domestic animals. PloS Neglected
Tropical Diseases 6(2): e1522. doi:10.1371/
journal.pntd.0001522.
58 Romano Ngui, Lee Soo Ching, Tan Tiong Kai,
Muhammad Aidil Roslan, Yvonne AL Lim (2012).
Genetic characterisation of human hookworm
infections in rural and remote areas of Peninsular
Malaysia. American Journal of Tropical Medicine
and Hygiene. In Press.
59 Velayutham TS, Abd Majid WH, Gan WC, Zak
AK, Gan SN, Theoretical and experimental
approach on dielectric properties of ZnO
nanoparticles and polyurethane/ZnO
nanocomposites. J. Appl. Phys. 2012 Sep; 112:
054106.
60 Velayutham TS, Abd Majid WH, Ng BK, Gan
SN, Effect of oleic acid content and chemical
1
Ayu SM, Lai LR, Chan YF, Hatim A, Hairi NN,
Ayob A , Sam IC. Seroprevalence survey of
Chikungunya virus in Bagan Panchor, Malaysia.
Am J. Trop Med Hyg. 2010 Dec;83(6):1245-8.
2
Nazir R, Mazhar M, Wakeel T, Akhtar MJ,
Siddique M, Nadeem M, Khan NA, Shah R.
Pyrolysis Mechanism of Trisbipyridineiron(II)
Chloride to Iron Nanoparticles. J. Therm Anal
Calorim (2011) DOI:10.1007/s10973-011-1919-5
3
S.S. Lee, N.H. Tan, S.Y. Fung, J. Pailoor, S.M.
Sim (2011) Evaluation of the sub-acute toxicity
of the sclerotium of Lignosus rhinocerus
(Cooke), the Tiger Milk mushroom, Journal of
Ethnopharmacology , 138:192-200.
4
Chow WZ, Al-Darraji H, Lee YM, Takebe Y,
Kamarulzaman A, Tee KK. Genome sequences
of a novel HIV-1 circulating recombinant form
(CRF) 53_01B identified in Malaysia. J Virol 2012;
86(20):11398-11399
5
Ng KT, Ong LY, Takebe Y, Kamarulzaman A,
Tee KK. Genome sequences of a novel HIV1 circulating recombinant form 54_01B from
Malaysia. J Virol 2012; 86(20):11405-11406
6
Pai YJ, Abdullah NL, Mohd-Zin SW, Mohammed
RS, Rolo A, Greene ND, Abdul-Aziz NM, Copp
AJ. (2012) Epithelial fusion during neural tube
morphogenesis.Birth Defects Res A Clin Mol
Teratol. 2012 Oct;94(10):817-23.
7
Chowdhary R, Street C, Travassos da Rosa A,
Nunes MR, Tee KK, Hutchison SK, Vasconcelos
PF, Tesh RB, Lipkin WI, Briese T. Genetic
characterization of the Wyeomyia group of
orthobunyaviruses and their phylogenetic
relationships. J Gen Virol 2012; 93(Pt. 5):10231034.
55
56
High Impact Research Annual Report 2012
8
Tee KK, Kamarulzaman A, Matano T, Takebe Y.
Phylodynamic inference of infectious diseases
caused by the human immunodeficiency virus,
enterovirus 71, and the 2009 swine-origin human
influenza virus. Future Virol 2012; 7(4):403-412.
(Review Article)
9
Tan, N.H. Fung, S.Y. and Yeannie Yap H.Y. (2012).
Isolation and characterization of the thrombinlike enzyme from Cryptelytrops albolabris
(white-lipped tree viper) venom. Comp. Biochem.
Physiol. B. 161, 79-85.)
10 Tan K H, Ahmad R, Johan M R, Electromagnetic
and microwave absorbing properties of
amorphous carbon nanotube-cadmium selenide
quantum dot hybrids, Material Chemistry and
Physics (2012).
11 Leong, P.K., Sim, S.M., Fung, S.Y., Sumana, K.,
Sitprija, V. Tan, N.H. (2012). Cross neutralization
of Afro-Asian cobra and Asian krait venoms
by a Thai polyvalent snake antivenom (Neuro
polyvalent snake antivenom). PloS Neglected
Tropical Diseases, 6, e1672.
12 Maria Szkudlarek-Mikho, Rudel A. Saunders,
Sook Fan Yap, Yun Fong Ngeow, Khew-Voon
Chin. Salinomycin, a polyether ionophoric
antibiotic, inhibits adipogenesis. Biochemical and
Biophysical Research Communications.2012 Oct
31. pii: S0006-291X(12)02072-4. doi: 10.1016/j.
bbrc.2012.10.080. [Epub ahead of print] IF:2.484
Tier 1 for Biophysics
13 Hidayah Mohd Khalid, Iswadi Jauhari, Adibah
Haneem Mohamad Dom. Development of
nanolayer HA on titanium alloy via superplastic
deformation method. Metallurgical and Materials
Transactions A. 2012 Oct ;43 (10): 3776-3785
14 Nor Wahida Ahamad and Iswadi Jauhari.
Carburizing of duplex stainless steel (DSS)
under compression superplastic deformation.
Metallurgical and Materials Transactions A. 2012
Dec;43(13):5115-5121
15 Sharidah Azuar Abdul Azis, Iswadi Jauhari, Nor
Wahida Ahamad Improving surface properties
and wear behaviors of duplex stainless steel
via pressure carburizing. Surface and Coating
Technology. 12 September 2012;(210):142-150
16 Lee, M.L., Tan,N.H., Fung, S.Y., Tan, C.S.
and Ng, S.T. (2012) The anti-proliferative
activity of sclerotia of Lignosus rhinocerus
(tiger milk mushroom). Evidence- Based
Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 697603, 5 pages
doi:10.1155/2012/697603
17 Abdul-Rahman, H., Wang, C., Woods, L., Low,
S.F. (2012). Negative Impact Induced by Foreign
Workers: Evidence in Malaysian Construction
Sector. Habitat International. 36: 433-443. (ISI
Indexed Journal, 2011 impact factor=1.434,
TIER 1).
18 Jiram A, vythilingam I, Noor Azian MY,Yusri
MY,Azahari AH,Fong MY. Entomologic
investigation of Plasmodium knowlesi vectors
in Kuala Lipis, Pahang. Malaysia Mal J. 2012
11:213
19 M.A.Kamarudin, A.Z.S.Zulkifli, S.M.Said. A
Review on the gel polymer electrolytes for
Dye-sensitized solar cell applications. J of Pwr
Sources (2012), POWER-D-12-02989.
LIST OF PRESENTATIONS HIR MOHE 2012 BY FACULTY
FACULTY OF MEDICINE
1
Mokhtar AS, Tay ST (2010). First detection
of Rickettsia felis, Bartonella hensale and B.
clarridgeiae from cat fleas (Ctenocephalides
felis) in Malaysia. Poster presented at the 15th
Biological Sciences Graduate Congress held
from 15-17th December 2010 at University
of Malaya. Mokhtar et al. (2011). Oral
presentation on 4th March 2011 at teh 47th
Annual Conference of the Malaysian Society
of Parasitology and Tropical Medicine at
International Medical University, Malaysia.
2
Umar Yagoub, Awang M Bulgiba, Didi EM,
Mustafa AM, Peramalah D, Christopher Lee,
Chik Z; Measuring adherence to Highly Active
Antiretroviral Treatment in HIV positive patients
in Sungai Boluh Hospital. Oral presentation in
APACPH 2010 in Bali Indonesia
3
Hun-Wei Ooi, Sazaly AbuBakar, Li-Yen Chang.
Molecular cloning and transfection studies of
Nipah virus V gene. International Conference
of the Malaysian Society for Microbiology,
Bayview Resort Penang, 9 - 11 Dec 2011 (Poster
presentation)
4
Vunjia Tiong, Chui-Wan Lam, Hun-Wei Ooi, WaiHong Phoon, Min-Han Lew, Sazaly AbuBakar,
Li-Yen Chang. Production of recombinant Nipah
virus proteins and its application in diagnosis
of a relapse case of Nipah virus infection.
International Conference of the Malaysian
Society for Microbiology, Bayview Resort
Penang, 9 - 11 Dec 2011 (Poster presentation)
5
Vellasamy KM, Mariappan V, Hashim OH,
Vadivelu J. The role of live bacteria and secretory
proteins of Burkholderia pseudomallei in host
pathogen interactions. International Congress
of The Malaysian Society for Microbiology
2011, 8-11 December, 2011, Penang, Malaysia.
Proceeding International Congress of the
Malaysian Society for Microbiology 2011.
Abstract no MM1; pp261
High Impact Research Annual Report 2012
6
Ong GH, Chang LY, Vadivelu J. Isolation and
characterisation of environmental Burkholderia
pseudomallei bacteriophages. International
Congress of The Malaysian Society for
Microbiology 2011, 8-11 December, 2011,
Penang, Malaysia. Proceeding International
Congress of the Malaysian Society for
Microbiology 2011. Abstract no MM10; pp395
7
Kang WT, Vellasamy KM, Chua EG, Vadivelu
J. Functional characterisation of type III
secretion system-3 effector protein BipC in
Burkholderia pseudomallei pathogenesis.
International Congress of The Malaysian Society
for Microbiology 2011, 8-11 December, 2011,
Penang, Malaysia. Abstract no Oral MM4; pp63
8
N. Sangeetha, J.H. Wong, S.R. Kanthan,
T. Ravindran and T. Kamarul. Histological,
Biochemical and Biomechanical Evaluation of
Osteoarthritic Induced Rat Models: Which Model
is Superior?. Malaysian Orthopaedic Association.
41st MOA AGM/ASM & 5th ASEAN Arthroplasty
Association Meeting. May 22nd -24th 2011,
Kuala Lumpur.
9
Sim, MS; Sulaiman, AH; Jaafar, ANFA; Mohamed,
Z. Association of SOD2 (superoxide dismutase 2)
genetic polymorphisms with methamphetamine
dependence in Malaysian population. Drug
Metabolism Reviews 2011 May. 43:69-70 (ISICited Publication)
10 Integration of Pharmacology Knowledge into
Clinical Practice, 8th Asia Pacific Medical
Education Conference, 28 Jan 2011 to 29 Jan
2011, Medical Education Unit of the National
University of Singapore, (International)
11 The Pharmacogenomics Approach to
Personalised Medicine., 1st Malaysia Conference
on Rare Disorders and Medical Genetics., 09 Jun
2011 to 10 Jun 2011, Human Variome Project
Consortium, (National). Kuala Lumpur
12 Association study of tryptophan hydroxylase
2 and serotonin transporter genes with major
depressive disorder in Malaysian ethnic
subgroups, 2nd Congress of the Asian
College of Neuropsychopharmacology, 23
Sep 2011 to 24 Sep 2011, Korean College of
Neuropsychopharmacology and Neuroscience,
(International). Seoul, Korea.
13 Pharmacogenomincs: Paving the Way to
Personalised Medicine., MGRC s 12th Eminent
Speaker Series. 23rd June 2011. Zahurin
Mohamed (Invited Speaker)., 23 Jun 2011 to 23
Jun 2011, Malaysian Genome Research Centre,
(National)
14 Association of ABCB1 polymorphisms with
response to sodium valproate in Malaysian
epilepsy patients., Asian Pacific International
Society for Study of Xenobiotics (APISSX) 2011.
22-25th April 2011. Z Mohamed, BS Haerian, KS
Lim, CT Tan (Oral Presentation)., 22 Apr 2011 to
25 Apr 2011, International Society for Study of
Xenobiotics, (International). Taiwan.
15 Association of INSIG2 RS7566605 Polymorphism
with obesity-related parameters in Malaysian
Malays, Human Genome Meeting 2011, 14
Mar 2011 to 17 Mar 2011, HUGO and UAE,
(International). Dubai, UAE.
16 Chiam CW, Chan YF, Ong KC, Wong KT, Sam IC.
Neurovirulence variation of different Chikungunya
virus genotypes in ICR suckling mice. 16th
Biological Sciences Graduate Congress, National
University of Singapore, Singapore, 12-13
December 2011
17 Helen-Ng LC, Razak IA, Ghani WMN,
Marhazlinda J, Norlida A, Zain RB. Dietary
consumption pattern and risk of oral cancer – a
Malaysia scenario. 3rd World Congress of the
International Academy of Oral Oncology, Yin and
Yang: Balancing Cure and Consequences, 14-17
July 2011, Grand Copthorne Waterfront Hotel,
Singapore. Oral Oncology Abstract no P98; pp
105.
18 Yap, M.K.K., Tan, N.H., Sim, S.M. and Fung,
S.Y. (2011) Pharmacokinetics of Naja sputatrix
(Javan spitting cobra) venom and the effect
of a neurotoxic polyvalent antivenom. Paper
presented at the 17th Congress of the European
Section of the International Society of Toxinology,
Sep 11th-15th, 2011. Valencia, Spain
19 Leong, P.K., Fung, S.Y., Sim, S.M. and Tan, N.H.
(2011). Cross neutralization of some Southeast
Asian cobra and krait venoms by Indian
polyvalent antivenoms. Paper presented at the
17th Congress of the European Section of the
International Society of Toxinology, Sep 11th15th, 2011. Valencia, Spain.
20 Umar Yagoub, Awang M Bulgiba, Didi EM,
Mustafa AM, Peramalah D, Christopher Lee,
Chik Z; Socio-demographic characteristics in
HIV positive patients on HAART in Sungai Buloh
Hospital. Poster presentation in APACPH in
Seoul South Korea 2011
21 Choh LC, Ong GH, Wong KT, Vadivelu J.
Dissecting the functional role of BapA protein
in Burkholderia pseudomallei pathogenesis.
International Congress of The Malaysian Society
for Microbiology 2011, 8-11 December, 2011,
Penang, Malaysia. Abstract no MM9; pp392
22 The Pharmacogenomics Approach to
Personalised Medicine., 1st Malaysia Conference
on Rare Disorders and Medical Genetics., 09 Jun
2011 to 10 Jun 2011, Human Variome Project
Consortium, (National). Kuala Lumpur
23 Pharmacogenomincs: Paving the Way to
Personalised Medicine., MGRC s 12th Eminent
Speaker Series. 23rd June 2011. Zahurin
Mohamed (Invited Speaker)., 23 Jun 2011 to 23
Jun 2011, Malaysian Genome Research Centre,
(National)
24 Association of INSIG2 RS7566605 Polymorphism
with obesity-related parameters in Malaysian
Malays, Human Genome Meeting 2011, 14
Mar 2011 to 17 Mar 2011, HUGO and UAE,
(International). Dubai, UAE.
25 Leong KH, Chung LY, Noordin MI, Onuki Y,
Morishita M, Takayama K. Lectin-functionalized
carboxymethylated kappa-carrageenan
microparticles for oral insulin delivery. Carb
Polym. 2011, 86: 555-565.
57
58
High Impact Research Annual Report 2012
26 Choh LC, Wong KT, Vadivelu, J. Role of BapA
involved in intracellular lifecycle of Burkholderia
pseudomallei. The 17th Biological Sciences
Graduate Congress 2012, 8-10 December, 2012,
Bangkok, Thailand. The 17th Biological Sciences
Graduate Congress Program and Abstracts.
Abstract no. CMB-PO16; pp 195
27 Bioethics and Society, Launching of the
National Bioethics Council and Presentaion of
the Letter of Appointment by the Minister of
Science, Technology and Innovation, YB Datuk
Seri Panglima Dr Maximus Johnity Ongkili, 22
May 2012 to 23 May 2012, Ministry of Science,
Technology and Innovation, (National)
28 Pharmacogenomics Studies in Multiethnic
Malaysians, Symposium for Genetic and
Genome Guided Personalized Medicine in Asia:
Overview and Applications, 02 Feb 2012 to 03
Feb 2012. Bangkok, Thailand. Thailand Center of
Excellence for Life Sciences (Public Organization)
together with Faculty of Medicine, Ramathibodi
Hospital, Mahidol University, Department of
Medical Sciences, Ministry of public Health,and
RIKEN, Japan, (International)
29 Peripheral PDLIM5 Expression in bipolar disorder
and the effect of olanzapine administration, 10th
Asia Pacific Conference on Human Genetics, 05
Dec 2012 to 08 Dec 2012, Asia Pacific Society of
Human Genetics, (International). Kuala Lumpur
30 Mariappan V, Vellasamy KM, Thimma J, Hashim
OH, Vadivelu J. Differential Host gene expression
upon exposure to live Burkholderia cepacia
and its secretory proteins. 15th International
Congress of Infectous Diseases, June 13-16,
2012, Bangkok, Thailand. Abstract no 45.049
35 Vellasamy KM, Mariappan V, Hashim OH,
Vadivelu J. Burkholderia pseudomallei hostpathogen interactions: role of live bacteria and
secretory proteins. 15th International Congress of
Infectous Diseases, June 13-16, 2012, Bangkok,
Thailand. Abstract no 46.061
36 Central adiposity and body composition as
indicators of dyslipidaemia among adolescents
in Kuala Lumpur: A case-control study, 26th
Scientific Meeting of Malaysian Society of
Pharmacology & Physiology, 18 May 2012 to 20
May 2012, Malaysian Society of Pharmacology
and Physiology, (National)
37 Sabet Negar Shafiei, Gupta Rishein, ChingYew
Beh, Abd-Jamil Juraina, Ngeow Yun-Fong,
Sofiah Sulaiman, Jamiyah Hassan, Arulanandam
Bernard P, AbuBakar Sazaly. Characterization
of Genital Chlamydia Trachomatis Infections
and Determination of Host Immune Responses
In Malaysian Woman of Reproductive Age 5th
Federation of Immunological Societies of AsiaOceania (FIMSA) Congress (March 14th-17th,
2012, New Delhi) Abstract N0 -330 -poster No130
38 One paper presented at the 17th Biological
Science Graduate Congress at Chulalongkorn
University, Bangkok, 8th-10th Dec 2012:
Application of Suppression Subtractive
Hybridization (SSH) to Generate Differential
Genes in Mycobacterium tuberculosis (Mtb)
isolates from Cerebrospinal Fluid (CSF) and
Respiratory Secretions. Saw S.H., Ngeow Y.F.,
Yong V.C. and Ng H.F.
31 Wai-Hong Phoon, Sazaly AbuBakar, Li-Yen
Chang. Construction and Expression of Nipah
Virus Nucleocapsid Gene in Escherichia coli.
Symposium of the Malaysian Society for
Microbiology, Promenade Hotel Sabah, 12 - 15
Dec 2012 (Poster Presentation)
39 Wong KT, Ong KC, Ng KY, Radotra B,
Shankar SK, Mahadevan A, Glatzel M, Sata T,
Shuangshoti S, Robertson T. Cellular targers of
virus infection in human rabies. 10th European
Congress of Neuropathology, Edinburgh,
Scotland, United Kingdom, 6-9 June 2012
(Abstract in Clinical Neuropathology 2012; 31:
305)
32 Vunjia Tiong, Sazaly AbuBakar, Li-Yen Chang.
Permissiveness And Survivability Studies Of
Nipah Virus Infection Of Human Monocytic
Thp-1 Cells Suggest A Role In Virus Spread.
Symposium of the Malaysian Society for
Microbiology, Promenade Hotel Sabah, 12 - 15
Dec 2012 (Poster Presentation)
40 Wong KT, Tan SH, Ong KC. Cranial nerves
are involved in viral entry into the brainstem
in a mouse model of Enterovirus 71
encephalomyelitis. 10th European Congress of
Neuropathology, Edinburgh, Scotland, United
Kingdom, 6-9 June 2012 (Abstract in Clinical
Neuropathology 2012; 31: 305-306)
33 Kalaiselvam K, Mariappan V, Vellasamy KM, NSK
Ramli, Al-Maleki AR, Vadivelu J. Comparative
proteomic analysis of large and small
colony morphology variants of Burkholderia
pseudomallei. The 1st Malaysian Proteomics
Conference 2012, September 26-27, 2012,
Penang, Malaysia. Asia-Pacific Journal of
Molecular Medicine 2012, 2(Suppl 1), Abstract no
PP07
41 Wong KT, Ng KY, Ong KC, Ng WF, Shankar
SK, Mahadevan A, Radotra B, Su IJ, Lau G,
Macorelles P. Enterovirus 71 and Japanese
encephalitis can be distinguished by distribution
of inflammation and intraneuronal detection of
viral antigen and RNA. 10th European Congress
of Neuropathology, Edinburgh, Scotland, United
Kingdom, 6-9 June 2012 (Abstract in Clinical
Neuropathology 2012; 31: 306)
34 Susceptibility and gene interaction study of
the angiotensin II type I receptor gene with
non-alcoholic fatty liver disease in a multiethnic population, 26th Scientific Meeting
of the Malaysian Society of Pharmacology
& Physiology, 18 May 2012 to 20 May 2012,
Malaysian Society of Pharmacology &
Physiology, (National)
42 K. T. Wong1, L. C. Eu1, K. C. Ong2, J. Vadivelu3,
Sheila Nathan4. Development of a specific
DNA probe that targets the 16s ribosomal
RNA for the detection and identification of
Burkholderia pseudomallei in infected tissues.
XXIA International Congress of the International
Acadmy of Pathology, Cape Town, South Africa,
30 sept – 5 Oct 2012
High Impact Research Annual Report 2012
43 Tan SH, Wong KT, Ong KC. Cranial nerves
are involved in viral entry into the brainstem
in a mouse model of Enterovirus 71
encephalomyelitis. International Environment and
Health Conference 2012. Penang, Malaysia, 6-7
June 2012.
44 Siti Idayu H, Rusdi AR, Muhammad Muhsin AZ,
Chong Guan N, Ahmad Hatim S, Fatimah I, Noor
Zuraini R, Rahimah AK, Muna M, Mohamad
Hussain H, Wan Azlinda Irnee WH. A study
on the effectiveness of electroacupuncture
as adjunctive treatment among methadone
maintenance therapy clients in University of
Malaysia Medical center, kuala Lumpur, Malaysia.
Abstracts from the 28th CINP World Congress
of Neuropsychopharmacology, Stockholm,
Sweden, 3–7 June 2012. (2012). The International
Journal of Neuropsychopharmacology,
15(SupplementS1), 1-271.doi:10.1017/
S1461145712000508. (ISI-cited publication).
45 Wan Azlinda Irnee WH, Siti Idayu H, Azhar
S, Muna M,Rusdi AR, Mohamad Hussain
H.Mohamad Hussain H. Amphetamine-type
stimulants use among drug users on the street
at Chow Kit Road, Kuala Lumpur, Malaysia.
Abstracts from the 28th CINP World Congress
of Neuropsychopharmacology, Stockholm,
Sweden, 3–7 June 2012. (2012). The International
Journal of Neuropsychopharmacology,
15(SupplementS1), 1-271. doi:10.1017/
S1461145712000508. (ISI-cited publication).
46 Pui-Fong Jee, Sazaly AbuBakar, Raha Abdul
Rahim, Li-Yen Chang. Refolded Fusion Protein
Consisting of the N-acetylmuraminidase (ACMA)
Anchor Region and Influenza Hemagglutinin
(HA1) Retains Its Binding Activity. Symposium
of the Malaysian Society for Microbiology,
Promenade Hotel Sabah, 12 - 15 Dec 2012 (Oral
Presentation)
47 Ong GH, Chang LY, Vadivelu J. Isolation and
characterisation of environmental phages of
Burkholderia pseudomallei. The 17th Biological
Sciences Graduate Congress 2012, 8-10
December, 2012, Bangkok, Thailand. The 17th
Biological Sciences Graduate Congress Program
and Abstracts. Abstract no CMB-PO24; pp 196
48 Farid S, Fatemeh Molaei V, Maysam O, Rusdi
AR, Mohamad Hussain H, Fatimah I. ( 2012).
Electro Acupuncture (EA) as an adjunct therapy
to methadone maintenance treatment (MMT)
in heroin addiction : A study of 2D EEG power
spectral topography and morlet wavelet.
Proceedings of the IEEE-EMBS International
Conference on Engineering & Sciences, 1719 December 2012, Langkawi, Malaysia.
Abstract no 1569659175 ;pp. 80-81 (ISI-Cited
Publication).
49 T.Zaman, A.A.Abbas, A.Suhaeb, S.Naveen. The
effects of Hyaluronic Acid and Allogenic Bone
Marrow derived-Mesenchymal stem cells in
delaying osteoarthritic progression of the knee:
A preliminary study. International Cartilage
Research Soceity (ICRS). 10th World Congress
Meeting. May 12-15th 2012, Montreal – Canada.
Poster No. 208.
50 Tan, C.S., Ng, S.T., Yeannie Yap, H.Y., Lee,S.S.,
Lee, M.L., Fung, S.Y., Tan, N.H., Tay, S.T. and
Sim, S.M. (2012). Breathing new life to a
Malaysian lost national treasure – the Tiger Milk
Mushroom (L. rhinocerus). Paper presented at
the 18th Congress of the International Society
of Mushroom Science, Aug 16th -30th, 2012.
Beijing, China
51 Ng, S.T., Tan, C.S., Yeannie Yap, H.Y., Fung,
S.Y., Tan, N.H. (2012). Molecular phylogeny
of L. rhinoceros (Tiger Milk Mushroom) based
on complete 18S and 28S ribosomal DNA
sequences. Paper presented at the 18th
Congress of the International Society of
Mushroom Science, Aug 16th -30th, 2012.
Beijing, China.
52 Lee, M.L., Tan, N.H., Fung, S.Y., Ng, S.T., and
Tan, C.S. (2012). Anti-proliferative activity of
tiger milk mushroom (L. rhinoceros) and gene
expression alterations of MCF-7 breast cancer
cells induced by treatment with the mushroom
extract. Paper presented at the 18th Congress of
the International Society of Mushroom Science,
Aug 16th -30th, 2012. Beijing, China
53 Yeannie Yap, H.Y., Tan, N.H., Fung, S.Y., Azlina,
A.A., Ng, S.T. and Tan, C.S. (2012). Evaluation of
antioxidant activity of Lignosus rhinoceros (tiger
milk mushroom) sclerotia. Paper presented at
the 18th Congress of the International Society
of Mushroom Science, Aug 16th -30th, 2012.
Beijing, China
54 Umar Y Mohammed, Awang M Bulgiba, Zamri
B chik, Christopher Lee, Devi Peramalah (2012).
Factors affecting adherence level to HAART
(Adherence predictors) in a major hospital in
Kuala Lumpur, Malaysia. 1st Asia Pacific Clinical
Epidemiology and Evidence Based Medicine
Conference (APCEEBM), Kuala Lumpur-Malaysia
55 Umar Y Mohammed, Awang M Bulgiba, Zamri
B chik, Christopher Lee, Devi Peramalah (2012).
Is Therapeutic Drug Monitoring (TDM) the
best method for measuring adherence level to
HAART in HIV positive patients in Kuala Lumpur
Malaysia? Oral presentation in APACPH 2012 in
Colombo Seri-lanka
56 Awang M Bulgiba, Umar Y Mohammed, Zamri
B chik, Christopher Lee, Devi Peramalah (2012).
How well does self-reported adherence fare
in relation to therapeutic drug monitoring in
HAART?.1st Asia Pacific Clinical Epidemiology
and Evidence Based Medicine Conference
(APCEEBM), Kuala Lumpur-Malaysia
57 Al-Maleki, A. R., Mariappan, V., Vellasamy,
K. M., Kalaiselvam, K., Loke, M. F., Tay, S. T.,
Vadivelu J. Comparative proteomic analysis of
colony morphology variants of Burkholderia
pseudomallei pre- and post-exposure to human
lung epithelial cells (A549). The 17th Biological
Sciences Graduate Congress 2012, 8-10
December, 2012, Bangkok, Thailand. The 17th
Biological Sciences Graduate Congress Program
and Abstracts. Abstract no BT-PO11; pp147
58 Shani Samuel, Sangeetha Naveen and T.
Kamarul. Growth Factor Quantification and
59
60
High Impact Research Annual Report 2012
The Cellular Induced Proliferation Potential
of Activated and Non-Activated Platelet Rich
Plasma on Human Mesencymal Stem Cells.
42nd Malaysian Orthopaedic Association,
Annual General Meeting /Annual Scientific
Meeting, 14 to 17 June 2012, Sultan Ahmad
Shah International Convention Centre, Kuantan,
Pahang.
59 Tan JAMA. Updates of prenatal diagnosis of
thalassaemia in Malaysia. 2012. Malaysian
Society of Haematology Mini Summit, Malacca,
Malaysia.
60 Chen JJ, Chua KH, Tan PC, George E, Tan
JAMA. 2012. Non-invasive prenatal diagnosis
using informative CpG sites: A possibility for
confirmation of β-thalassaemia mutations in
foetal DNA. 10th Asia Pacific Conference on
Human Genetics, Kuala Lumpur, Malaysia
61 Kho SL, Chua KH, George E, Tan JAMA. 2012.
Specific molecular characterisation of β-globin
gene mutations using Quantitative Real-time
PCR: A rapid and effective molecular screening
technique for thalassaemia in Malaysia. 10th Asia
Pacific Conference on Human Genetics, Kuala
Lumpur, Malaysia
62 M.S. Kanthimathi, J. Rajarajeswaran. 2012.
Dietary spices inhibit cancer cell migration and
protect against DNA damage.16th Biennial
Meeting of the Society for Free Radical Research
International, Imperial College, London. S83
63 Jayakumar Rajarajeswaran and M.S.Kanthimathi
(2012) Anticancer activity and inhibition of
cancer cell migration of spice essential oils.37th
Annual Conference of the Malaysian Society for
Biochemistry and Molecular Biology, Sime Darby
Convention Centre, Kuala Lumpur: 78
64 Esther Tang Lai Har, R.Jayakumar, Fung Shin
Yee and M.S.Kanthimathi (2012) Coriandrum
sativum and Petroselinum crispum inhibit
cancer cell migration and protect against
hydrogen peroxide-induced DNA damage.37th
Annual Conference of the Malaysian Society for
Biochemistry and Molecular Biology, Sime Darby
Convention Centre, Kuala Lumpur: 69
65 Hookworm Navigator- Rapid detection assay for
human hookworm species (2012). BioMalaysia
2012, KLCC, Kuala Lumpur
66 Kuppusamy, U.R., Ng, Z. X., Chua, K.H.,
Richardson, J.S., Abdul Malek, S.N. (2012,
November). Use of customized cooking methods
to improve antioxidant & nutritional values of
selected vegetables. Abstract presented at The
4th International Conference on Natural Products
for Health & Beauty (NATPRO4), Chiang Mai
University, Thailand
67 Sarasvathy, S., Vikineswary, S. Tan, W.C,
Kuppusamy, U.R. (2012, November). Study of
antioxidant activity of fresh fruiting bodies of
Ganoderma neo-japonicum extracts. Abstract
presented at The 4th International Conference on
Natural Products for Health & Beauty (NATPRO4),
Chiang Mai University, Thailand
68 Arumugam, B., Manaharan, B., Chua, K.H.,
Palanisamy, U.D., Kuppusamy, U.R. (2012,
November). Antioxidant properties of Syzygium
aqueum and its protective role against hydrogen
peroxide-induced oxidative stress in 3T3-L1
preadipocytes. Abstract presented at The 4th
International Conference on Natural Products
for Health & Beauty (NATPRO4), Chiang Mai
University, Thailand
69 Tan, X.C., Chua, K.H., Kuppusamy, U.R.
(2012, December). Prolonged oxidative stress
stimulates differentiation and lipogenesis in 3T3L1 adipocytes. Abstract presented at The 17th
Biological Sciences Graduate Congress (17TH
BSGC), Chulalongkorn University, Thailand
70 Baskaran, A., Vikineswary, S. Kuppusamy,
U.R. (2012, December). Inhibition of
lipopolysaccharide-induced nitric oxide
production in RAW 264.7 macrophage by
extracts of selected medicinal mushrooms.
Abstract presented at The 17th Biological
Sciences Graduate Congress (17TH BSGC),
Chulalongkorn University, Thailand
71 Hashim OH. Writing and Publishing of
Manuscripts. Publish or Perish Seminar, Advance
Medical and Dental Institute, Universiti Sains
Malaysia, Kepala Batas, 18th June, 2012.
72 Hashim OH. Selective past proteomics studies
at UMCPR. UMCPR Research Day and
Proteomics Workshop, Faculty of Medicine,
University of Malaya, 21st June, 2012.
73 Hashim OH. Champedak lectins: From the
humble seed to targeted proteomics. 37th
Annual Conference of the Malaysian Society for
Biochemistry and Molecular Biology, 18-19 July
2012, Sime Darby Convention Centre, Kuala
Lumpur. Abstract no Plenary 1; pp 22.
74 Hashim OH. Selective past proteomics studies
at UMCPR. Australian Proteome Analysis Facility
(APAF) – UMCPR Meeting, Faculty of Medicine,
University of Malaya, 24th Sept, 2012.
75 Hashim OH. Selective past proteomics studies
at UMCPR. Australian Proteome Analysis Facility
(APAF) – UMCPR Meeting, Faculty of Medicine,
University of Malaya, 24th September, 2012.
76 Chong URW, Abdul-Rahman PS, Abdul-Aziz A,
Hashim OH, Mat-Junit S. Tamarindus indica
fruit pulp extract alters the secretion of lipidassociated proteins from HEP2 cells. 37th
Annual Conference of the Malaysian Society for
Biochemistry and Molecular Biology, 18-19 July
2012, Sime Darby Convention Centre, Kuala
Lumpur. Abstract no P10; pp 65.
77 Razali N, Abdul-Aziz A, Mat-Junit S. Gene
expression profiles in human HEP2 cells treated
with methanol extract of the Tamarindus indica
seeds. 37th Annual Conference of the Malaysian
Society for Biochemistry and Molecular Biology,
18-19 July 2012, Sime Darby Convention Centre,
Kuala Lumpur. Abstract no P45; pp 99.
78 Kong KW, Mat-Junit S, Aminudin N, Ismail
A, Abdul-Aziz A. Protective effects of water
extracts from Barringtonia racemosa shoots
towards in vitro oxidation of human serum, low
density lipoprotein and haemoglobin. 37th
Annual Conference of the Malaysian Society for
High Impact Research Annual Report 2012
Biochemistry and Molecular Biology, 18-19 July
2012, Sime Darby Convention Centre, Kuala
Lumpur. Abstract no P87; pp 141.
Hospital, Mahidol University, Department of
Medical Sciences, Ministry of public Health,and
RIKEN, Japan, (International)
79 Juvarajah T, Hashim OH, Fung SY, AbdulRahman PS. Proteomic profiling of milk fat
globule membrane proteins of ruminants and
humans. 1st Malaysian Proteomics Conference,
26-27 September 2012, Eastin Hotel, Penang.
Abstract no O23; pp 38.
88 NorAmdan, N. A. & AbuBakar, S. (2012,
November). Cloning, expression and purification
of Burkholderia pseudomallei antigenic protein.
Paper presented at the International Conference
on Clinical Microbiology & Microbial Genomics,
San Antonio, Texas
80 Determinants of unsuccessful tuberculosis
treatment outcome in Malaysian HIV-infected
patients. Proceeding of the 1st Asia Pacific
Clinical Epidemiology and Evidence Based
Medicine Conference, 6-8 July 2012, Kuala
Lumpur.
89 Central adiposity and body composition as
indicators of dyslipidaemia among adolescents
in Kuala Lumpur: A case-control study, 26th
Scientific Meeting of Malaysian Society of
Pharmacology & Physiology, 18 May 2012 to 20
May 2012, Malaysian Society of Pharmacology
and Physiology, (National)
81 Predictors of survival in TB/HIV co-infected
patients in Klang Valley. Proceeding of the 2nd
International Public Health Conference & 19th
National Public Health Colloquium Conference ,
3-4 October 2012, Kuala Lumpur
82 Zaki, R., Bulgiba, A., & Ismail, N. A.
Overestimation bias. 1st Asia Pacific Clinical
Epidemiology & Evidence Based Medicine
(APCEEBM) Conference, Kuala Lumpur. 6 – 8
July 2012. Oral presentation
83 Kamarul, T; Kamisan, B N; Ahmad, R E; Naveen,
S. Cartilage of different mammalian species
demonstrate variable tissue thickness, cell
density, proteoglycan content and cartilage
specific genes. 42nd Malaysian Orthopaedic
Association, Annual General Meeting /Annual
Scientific Meeting, 14 to 17 June 2012, Sultan
Ahmad Shah International Convention Centre,
Kuantan, Pahang. Oral Presentation for
Mahmood Merican Award.
84 HY Nam, B Pingguan-Murphy, AA Abbas, AM
Merican, T Kamarul. A Preliminary Report on
the Behaviour of Human Bone Marrow DerivedMesenchymal Stem Cells during Uniaxial
Cyclic Loading. 42nd Malaysian Orthopaedic
Association, Annual General Meeting /Annual
Scientific Meeting, 14 to 17 June 2012, Sultan
Ahmad Shah International Convention Centre,
Kuantan, Pahang.
85 Kamarul, T; Kamisan, B N; Ahmad, R E; Naveen,
S. Cartilage of different mammalian species
demonstrate variable tissue thickness, cell
density, proteoglycan content and cartilage
specific genes. 42nd Malaysian Orthopaedic
Association, Annual General Meeting /Annual
Scientific Meeting, 14 to 17 June 2012, Sultan
Ahmad Shah International Convention Centre,
Kuantan, Pahang. Oral Presentation for
Mahmood Merican Award.
86 Predictors of Survival in Malaysian HIV infected
patients on anti-retroviral therapy. APCEBM
conference in 2012, oral presentation
87 Pharmacogenomics Studies in Multiethnic
Malaysians, Symposium for Genetic and
Genome Guided Personalized Medicine in Asia:
Overview and Applications, 02 Feb 2012 to 03
Feb 2012. Bangkok, Thailand. Thailand Center of
Excellence for Life Sciences (Public Organization)
together with Faculty of Medicine, Ramathibodi
90 Chin Y, Lim SH, Kiew LV, Chung LY, Lee HB,
Zorlu Yunus, Ahsen V, Dumoulin F. Improved
efficacy of modified Zinc(II) phthalocyanines
as photosensitizers for phtodynamic therapy.
26th Scientific Meeting of Malaysian Society of
Pharmacology & Physiology (MSPP2012), 18-20
May 2012, Equatorial Hotel, Penang. Abstract
No. P015; pp. 92.
91 Lim SH, Wu L, Kiew LV, Burgess K, Chung LY,
Lee HB. Rosamines target the cancer oxidative
phosphorylation pathway: In vitro and in vivo.
26th Scientific Meeting of Malaysian Society of
Pharmacology & Physiology (MSPP2012), 18-20
May 2012, Equatorial Hotel, Penang. Abstract
No. P016; pp.92.
92 Chin Y, Kiew LV, Chung LY, Zorlu Y, Ahsen
V, Dumoulin F, Lee HB, Lim SH. Glycerol
substituted Zn(II)-phthalocyanines as
photosensitizers for PDT treatment of cancer.
9th International Symposium on Photodynamic
Therapy and Photodiagnosis in Clinical Practice,
and 4th International Meeting of the European
Platform for Phtodynamic Medicine (EPPM), 1620 October 2012, South Tyrol, Italy. Abstract No./
Poster No. 54; pp. 59.
FACULTY OF ENGINEERING
1
Hayyan M., Mjalli F.S., Hashim M. A., Hayyan A.,
AlNashef I. M., Purification of Palm Oil-Based
Fatty Acid Methyl Ester Using Deep Eutectic
Solvents, 102nd American Oil Society (AOCS)
Annual Meeting and Expo, Cincinnati, Ohaio,
USA, 2011.
2
Hayyan A., Hashim M. A, Mjalli F.S. , Hayyan M.,,
AlNashef I. M., Reduction of Free Fatty Acids
in Crude Palm Oil Via Trifluoromethanesulfonic
Acid, 102nd American Oil Society (AOCS)Annual
Meeting and Expo, Cincinnati, Ohaio, USA, 2011.
3
Hayyan M., Mjalli F.S., Hashim M. A., Hayyan
A., AlNashef I. M.,Electrochemical generation
of Superoxide Ion-Radical in 1-Hexy-1-Methy1Pyrrolidinum bis (Tryfluoromethylsulfunnyl), 2nd
International Conference on Biotechnology
Engineering (ICBioE’11), International Islamic
University Malaysia, Kuala Lumpur, Malaysia,
2011.
61
62
High Impact Research Annual Report 2012
4
Hayyan M., Mjalli F. S., Hashim M. A., AlNashef
I. M., Investigating The Stability of Superoxide
Ion-Radical in Bis (Trifluoromethylsulfonyl) ImideBased Ionic Liquids, International congress on
Green Process Engineering (GPE2011), Kuala
Lumpur, Malaysia, 2011.
14 Abnisa F, Wan Daud WMA, Sahu JN. Pyrolysis of
palm shell and polystyrene mixtures: an optional
technique to obtain the high-grade of pyrolytic
liquid. Proceedings of the Fourth International
Symposiumon Energy From Biomass And Waste,
Venice, Italy, November 12-15, 2011.
5
Hayyan M., Mjalli F. S., Hashim M. A., AlNashef
I. M., Utilizing of Tris(pentafluoroethyl)
trifluorophosphate Anion Based-Ionic Liquids
as Media for Generation of Superoxide Ion, The
Fourth International Chemistry Conference,
Riyadh- Kingdom of Saudi Arabia, 2011.
6
Liaquat AM, Masjuki HH, Kalam MA, Varman
M, Hazrat, MA, Shahabuddin M, Mofijur M.
Application of blend fuels in a diesel engine. 2nd
International Conference on Advances in Energy
Engineering (ICAEE 2011), 27-28 December
2011,Bangkok, Thailand.
15 Helen-Ng LC, Razak IA, Ghani WMN,
Marhazlinda J, Norlida A, Zain RB. Dietary
consumption pattern and risk of oral cancer – a
Malaysia scenario. 3rd World Congress of the
International Academy of Oral Oncology, Yin and
Yang: Balancing Cure and Consequences, 14-17
July 2011, Grand Copthorne Waterfront Hotel,
Singapore. Oral Oncology Abstract no P98; pp
105.
7
Liaquat AM, Masjuki HH, Kalam MA, Varman
M. Friction and wear characteristic of waste
vegetable oil contaiminated lubricants. Regional
Tribology Conference (RTC 2011), 22-24
November 2011, Bayview Hotel, Langkawi,
Malaysia.
16 Helen-Ng LC, Razak IA, Ghani WMN,
Marhazlinda J, Norlida A, Zain RB. Dietary
consumption pattern and risk of oral cancer – a
Malaysia scenario. 3rd World Congress of the
International Academy of Oral Oncology, Yin and
Yang: Balancing Cure and Consequences, 14-17
July 2011, Grand Copthorne Waterfront Hotel,
Singapore. Oral Oncology Abstract no P98; pp
105.
8
Liaquat AM, Masjuki HH, Kalam MA, Varman,
M, Hazrat MA. Experimental analysis on engine
performance and emission characteristics using
biodiesel obtained from non-edible oil. Regional
Conference on Automotive Research (ReCAR
2011), 14-15 December 2011, Kuala Lumpur,
Malaysia.
17 A. Mahmoudi, N. A. Rahim, W. P. Hew, “A
Comparison between the TORUS and AFIR
Axial-Flux Permanent-Magnet Machine Using
Finite Element Analysis” IEEE International
Electric Machine and Drives Conference
(IEMDC), Nigara Fall, Canada, 15th - 18th May,
2011.
9
Mofijur M, Masjuki HH, Kalam MA, Shahabuddin
M, Hazrat MA, Liaquat AM. Palm oil methyl
ester and its emulsions effect on lubricant
performance and engine components wear. 2nd
International Conference on Advances in Energy
Engineering (ICAEE 2011), 27-28 December
2011, Bangkok,Thailand.
18 M. A. Hashim, A. Hayyan, F. S. Mjalli, Y. M.
Al-Wahaibi, T. Al-Wahaibi, M. Hayyan, I. M.
AlNashef Biodiesel Production from Acidic Crude
Palm Oil using Two-Step Processes International
conference in Energy Development Research,
Kuwait, April 2012.
10 Shahabuddin M, Masjuki HH, Kalam MA, Mofijur
M, Hazrat MA, Liaquat AM. Effect of additive
on performance of C.I. engine fuelled with
bio diesel. 2nd International Conference on
Advances in Energy Engineering (ICAEE 2011),
27-28 December 2011, Bangkok, Thailand.
11 Shahbaz K., Mjalli F. S., Hashim M. A., Al Nashef
I. M., Elimination of free glycerol from palm oilbased biodiesel using phosphonium-based ionic
liquids analogues, 3rd International Congress on
Green Process Engineering (GPE 2011), Kuala
Lumpur, Malaysia, 2011.
12 Moo, E.K., Abu Osman, N.A., Pingguan-Murphy,
B., Han, S. K., Federico, S., Herzog, W.(2011).
Mechanical Behavior of in-situ Chondrocyte at
Different Loading Rates: A Finite Element Study.
Biomed2011, IFMBE Proceedings 35, 182-186.
(Kuala Lumpur, Malaysia, June 20th - 23rd, 2011)
13 Moo, E. K., Herzog, W., Han, S. K., Abu Osman,
N. A., Pingguan-Murphy, B., Federico, S. In-situ
Chondrocyte Mechanics at Different Loading
Rates: A Finite Element Study. Proceedings of
the12th Annual Alberta Biomedical Engineering
Conference, 29. (Banff, Canada, October 21st23rd, 2011)
19 Mukhtar A. Kareem, Farouq S. Mjalli, Mohd. Ali
Hashim, Inas M. AlNashef, Fatemeh Saadat
Ghareh Bagh. Reducing energy consumption in
ethylene production by green solvents utilization.
International Conference on Environmental
Research and Technology 2012, Penang,
Malaysia
20 Mukhtar A. Kareem, Farouq S. Mjalli, Mohd. Ali
Hashim, Inas M. AlNashef, Fatemeh Saadat
Ghareh Bagh. Application of deep eutectic
solvents based on ethylene glycol and sulfolane
for the extraction of toluene from toluene/
heptane mixtures. International Conference on
Process Engineering and Advanced Materials
2012, Kuala Lumpur, Malaysia
21 Kaveh shahbaz, Saeid Baroutian, Farouq S.
Mjalli, Mohd Ali Hashim, Inas M. AlNashef.
Artificial Intelligent Techniques for Modeling
the Glycerol Removal from Biodiesel using
Ammonium and Phosphunium Based Deep
Eutectic Solvents. International Conference on
Global Sustainability and Chemical Engineering
(ICGSCE 2012), Shah Alma, Malaysia, 2012.
22 Kaveh shahbaz, Farouq S. Mjalli, Mohd Ali
Hashim, Inas M. AlNashef.Purification of palm
oil-based biodiesel using deep eutectic solvents.
High Impact Research Annual Report 2012
University of Malaya Researcher’s Conference
(UMRC 2012), Kuala Lumpur, Malaysia, 2012
23 M. Karimi,H. Mokhlis, A.H.A Bakar, A. Shahriari,
M.A. Faradonbeh, H.M. Rosli,”Impact of load
modeling in distribution state estimation”,6th
International Power Engineering and Optimization
Conference (PEOCO2012),pp.67- 71, 6-7 June
2012 doi: 10.1109/PEOCO.2012.6230837
24 M. Karimi,H. Mokhlis, A.H.A Bakar, A. Shahriari,
M.A. Faradonbeh, H.M. Rosli,”Impact of load
modeling in distribution state estimation”,6th
International Power Engineering and Optimization
Conference (PEOCO2012),pp.67- 71, 6-7 June
2012 doi: 10.1109/PEOCO.2012.6230837
25 M. Karimi, H.Mokhlis, A.H.A. Bakar, J.A.
Laghari, A. Shahriari,M.M. Aman,”Combination
of adaptive and intelligent load shedding
techniques for distribution network”,6th
International Power Engineering and Optimization
Conference (PEOCO2012),pp.57-61, 6-7 June
2012 doi:10.1109/PEOCO.2012.6230835
26 RAMIN HOSSEINI KUPAEI, U.JOHNSON
ALENGARAM , MOHD ZAMIN BIN JUMMAT. A
REVIEW ON FLY ASH-BASED GEOPOLYMER
CONCRETE. 11th International Conference on
Concrete Engineering and Technology 2012
(CONCET2012).11th –14th June 2012, Putrajaya,
Malaysia, pp 174-180.
27 B.A. AL MUHIT, U.J. ALENGARAM, MOHD.
Z. JUMAAT, K.Y.FOONG. GEOPOLYMER
CONCRETE: A BUILDING MATERIAL FOR
THE FUTURE. 11th International Conference
on Concrete Engineering and Technology 2012
(CONCET2012).11th –14th June 2012, Putrajaya,
Malaysia, pp 102-107.
28 U. JOHNSON ALENGARAM and B.A.AL. MUHIT.
Mechanical Properties of Oil Palm Shell Foamed
Concrete: A Micro-structural Approach Using
SEM. Research, Development, and Practice
in Structural Engineering and Construction.
Vimonsatit, V., Singh, A., Yazdani, S. (eds.).
ASEA-SEC-1, Perth, November 28–Decmber 2,
2012
29 T. Ariga, Y. Miyazawa, M. Hamdi, M. Sekine,
K. Kanda. Attached Effect of Porous Metal in
a Brazed Joint. IBSC 2012: Proceedings from
the 5th International Brazing and Soldering
Conference, April 22–25, 2012, Las Vegas,
Nevada, USA.
30 H. Nashrah, Y. Farazila, M. Hamdi. Effect of
Adding Porous Cu on the Microstructure and
Mechanical Properties of Pb-Free Solder Joint.
35th International Electronic Manufacturing
Technology Conference, November 6-8, 2012,
Kinta River Front Hotel, Ipoh, Perak, Malaysia.
31 Liaquat AM, Masjuki HH, Kalam MA, Bhuiya
MMK, Varman M. Influence of coconut biodiesel
and waste cooking oil blended fuels on engine
performance and emission characteristics.
Proceedings of the 2012 Fall Conference of
the ASME Internal Combustion Engine Division
(ICEF2012), 23-26 September 2012, Vancouver,
BC, Canada.
32 Liaquat AM, Masjuki HH, Kalam MA, Varman M.
Impact of biodiesel on injector deposit formation.
5th AUN/SEED-Net Regional Conference on
New/Renewable Energy 26-27 September 2012,
School of Transportation Engineering, Hanoi
University of Science and Technology.
33 Liaquat AM, Masjuki HH, Kalam MA, Varman M.
Engine performance and exhaust emissions of
a single cylinder CI engine fuelled with coconut
biodiesel blended fuels. 5th AUN/SEED-Net
Regional Conference on New/Renewable Energy
26-27 September 2012, School of Transportation
Engineering, Hanoi University of Science and
Technology.
34 Shahabuddin M, Masjuki HH, Kalam MA,
Zulkifli NWM, Nazira V, Mofijur M. Biofuel:
potential energy source in road transportation
sector in Malaysia. International Conference
on Sustainable Future Energy 2012 and 10th
SEE FORUM Innovations for Sustainable and
Secure Energy, 21-23 November 2012, Brunei
Darussalam.
35 Liaquat AM, Masjuki HH, Kalam MA, Rizwanul
Fattah IM, Hazrat MA, Varman M, Mofijur M,
Shahabuddin M. Effect of coconut biodiesel
blended fuels on engine performance and
emission characteristics. 5th BSME International
Conference on Thermal Engineering, 21-23
December 2012, Dhaka, Bangladesh.
36 Shahabuddin M, Masjuki HH, Kalam MA.
Experimental investigation into tribological
characteristics of bio-lubricant formulated from
Jatropha oil. 5th BSME International Conference
on Thermal Engineering, 21-23 December 2012,
Dhaka, Bangladesh.
37 Chai AB, Andriyana A, Verron E, Johan MR. A
pseudo-elastic model for the Mullins effect in
swollen rubber. 4th International Conference on
Solid State Science and Technology (ICSSST).
18-20 December 2012. Malacca, Malaysia.
38 Loo MS, Andriyana A, Verron E, Chagnon G, Afifi
AM. Mullins effect in swollen rubber under cyclic
loading. International Conference on Automotive
and Materials Engineering (ICAME’2012). 27-28
November 2012. Penang, Malaysia
39 Chai AB, Andriyana A, Verron E, Johan MR.
Diffusion of biodiesel in rubber and the resulting
mechanical response under cyclic loading.
Proceedings of 8th International Conference on
Diffusion in Solids and Liquids (DSL). 25-29 June
2012. Turkey, Istanbul.
40 Ch’ng SY, Andriyana A, Verron E, Ahmad
R. Diffusion of palm biodiesel in elastomers
undergoing multiaxial large deformations.
Proceedings of 8th International Conference on
Diffusion in Solids and Liquids (DSL). 25-29 June
2012. Turkey, Istanbul.
41 Ch’ng SY, Andriyana A, Verron E, Ahmad R.
Asian International Conference on Materials,
Minerals, and Polymer 2012 (MAMIP2012). 23-24
March, 2012. Penang, Malaysia.
42 M. Hamdi, Y. Farazila, M. Fadzil, T. Zaharinie, T.
Ariga. The International Conference on Integrated
63
64
High Impact Research Annual Report 2012
Systems, Design and Technology, May 12-15,
2012, Mallorca, Spain.
43 Y. Farazila. A Feasibility Study on the Friction Stir
Welding (FSW) of Ultra-Thin Sheet Aluminium
Alloy. 3rd UKM-NUT Joint Seminar, October
13, 2012, Puri Pujangga, Universiti Kebangsaan
Malaysia, Bangi, Selangor.
44 Moo, E. K., Federico, S., Han, S. K., Abu Osman,
N. A., Pingguan-Murphy, B, Herzog, W. Articular
Chondrocyte Mechanics at Different Loading
Rates. Proceedings of the17th Biennial Meeting
of the Canadian Society of Biomechanics
(Vancouver, Canada, June 6 th-9th, 2012 )
45 Moo, E. K. , Han, S. K., Jinha, A., Abusara,
Z., Abu Osman, N.A., Pingguan-Murphy,
B., Herzog, W. Boundary Conditions Affect
Mechanical Behaviour of in-situ Chondrocytes.
36 th Annual Meeting of the American Society
of Biomechanics (Gainesville, Florida, United
States, August 15th-18th, 2012)
46 Moo, E. K., Amrein, M., Abu Osman, N. A.,
Pingguan-Murphy, B., Herzog, W. Chondrocyte
Membrane Mechanics at Different Loading
Rates. Proceedings of the13th Annual Alberta
Biomedical Engineering Conference, 103. (Banff,
Canada, October 19th-21st, 2012)
47 Nor Elleeiana Mohd Syah, Nur Azah Hamzaid,
Noor Azuan Abu Osman, Chung Tze Yang
(2012). Gait Characterization across Different
Profile of Prosthesis and Orthosis User’s:
Towards Developing A New Smart Prosthetic
Leg. 2012 World Congress on Medical Physics
and Biomedical Engineering (WC2012). Beijing,
China, May 26-31, 2012.
48 Y. Farazila. Utilizing friction spot joining for
dissimilar joint of aluminum alloy (A5052) and
polyethylene terephthalate (PET). JWRI-UM
seminar 2012, November 21, 2012, JWRI, Osaka
University.
49 M. M. Hasan, A. Mahrous, S. Mekhilef “Analyses
and Simulation of Three-phase MLI with High
Value of Resolution per Switch employing SVM
control scheme” 2012 IEEE International Power
and Energy Conference (PECON 2012),Sabah,
Malaysia, 2 - 5 Dec 2012
50 M. M. Hasan, A. Mahrous, S. Mekhilef
“Simulation and Analyses of 3-Phase 27-Level
Inverter using SVM Control Scheme” Fifteenth
International Middle East Power Systems
Conference MEPCON’12 Alexandria, Egypt,
December, 23-25, 2012
51 S. Mekhilef, H.I. Khudhur, H. Belkamel, DC link
capacitor voltage balancing in three level neutral
point clamped inverter, Control and Modeling for
Power Electronics (COMPEL), 2012 IEEE 13th
Workshop on, 2012, pp. 1-4
52 N.M. Karim, S. Manzoor, N. Soin, S.F. Yew, M.
Mounir. Prediction of energy change due to hot
carrier injection. Presented in MNE 2012.
53 S. P. YAP, K.Y. FOONG, U. J. ALENGARAM & M.
Z. JUMAAT. WASTE MATERIALS IN MALAYSIA
FOR THE DEVELOPMENT OF SUSTAINABLE
CONCRETE: A REVIEW. 11th International
Conference on Concrete Engineering and
Technology 2012 (CONCET2012).11th –14th
June 2012, Putrajaya, Malaysia, pp 113-118.
54 S. Kahourzade, A. Mahmoudi, N. A. Rahim,
and H. W. Ping “Sizing Equation and Finite
Element Analysis Optimum Design of AxialFlux Permanent-Magnet Motor for Electric
Vehicle Direct Drive” IEEE International Power
Engineering and Optimization Conference,
Melaka, Malaysia 2012, 6th - 7th June 2012.
55 Chong,H.Y., Dahari,M., Yap,H.J., Loong,
Y.T. Development of Hazard Assessment for
Hydrogen Refueling Station in Malaysia. 3rd
International Conference on Mechanical and
Manufacturing Engineering 2012, University Tun
Hussein Onn Malaysia (UTHM), Malaysia.
56 N.M. Karim, S. Manzoor, N. Soin. Statistical
forecasting algorithm on circuit level gain
transformation due to negative bias temperature
instability under microwave frequency spectrum.
Presented in Nanosmat 2012.
57 Y.Abdul Wahab, A.F. Ahmad, H. Hussin, S.
Shahabuddin, N. Soin. 2012. Integrated Diffuser
Process Optimizations on Defect Metrology
Performance. 38th International Micro & Nano
Engineering Conference (MNE 2012). Presented
58 Y.Abdul Wahab, A.F. Ahmad, H. Hussin, N.
Soin. 2012. Reduction of Annealed Induced
Wafer Defects in Dual-Damascene Copper
Interconnects. 23rd European Symposium on
Reliability of Electron Devices, SeptemberOctober 2012, Presented.
59 N. Soin, S. Shahabuddin, K.K. Goh, Y. Abdul
Wahab, H. Hussin, Experimental Degradation
Analysis in Lateral DMOS Transistors. MNE 2012.
Presented.
60 N. Soin, S.S. Shahabuddin, K.K. Goh,
Measurement and Characterization of Hot
Carrier Safe Operating Area (HCI-SOA) in 24V
n-type Lateral DMOS Transistors. ICSE 2012.
Presented.
61 M.H. Kamaruddin, N. Soin. Application of
Three-terminal Charge Pumping Measurement in
trench-gate DMOS Fowler-Nordheim tunnelling
stress. MNE 2012. (Presented)
62 T. Zaharinie, Y. Farazila, M. Hamdi, T. Ariga.
A Study on Interfacial Reaction and Titanium
Distribution in Brazing Sapphire to Inconel 600
Using Cu/Ni Porous Composite. IBSC 2012:
Proceedings from the 5th International Brazing
and Soldering Conference, April 22–25, 2012,
Las Vegas, Nevada, USA.
63 B. Rismanchi, R. Saidur, H.H. Masjuki, T.M.I.
Mahlia, Cost-benefit analysis of using cold
thermal energy storage systems in building
applications, 2012, pp. 493-8.
64 Chong WT, Poh SC, Fazlizan A, Yip SY, Koay
MH and Hew WP. Exhaust air energy recovery
system for electrical power generation in future
green cities. International Symposium on Green
Manufacturing and Applications (ISGMA 2012).
May 2012, Jeju, Korea.
65 Chong WT, Poh SC, Fazlizan A, Yip SY and Hew
WP. The design and testing of an exhaust air
High Impact Research Annual Report 2012
energy recovery wind turbine generator. World
Renewable Energy Froum (WREF 2012), May
2012, Denver, US.
66 Chong WT, Fazlizan A, Poh SC, Pan KC, and
Hew WP. The design, simulation and testing of
an urban vertical axis wind turbine with the omnidirection-guide-vane. International Conference
on Applied Energy, (ICAE 2012), Jul 5-8, 2012,
Suzhou, China
67 A. Saghafinia, S. Kahourzade, A. Mahmoudi,
W. P. Hew, M. Nasir Uddin, “On Line Trained
Fuzzy Logic and Adaptive Continuous Wavelet
Transform Based High Precision Fault Detection
of IM with Broken Rotor Bars” 47th IEEE IAS
Annual Meeting, Las Vegas, NV, USA, 7th – 11th
October 2012.
68 Loong, Y.T., Dahari,M., Yap,H.J.,Chong,H.Y.
Modeling and Simulation of Solar Powered
Hydrogen System. 3rd International Conference
on Mechanical and Manufacturing Engineering
2012, University Tun Hussein Onn Malaysia
(UTHM), Malaysia.
FACULTY OF SCIENCE
1
Abdelahhad Barbour, Koshy Philip and Sekaran
Muniandy (2011). Production of Lantibiotic
Salivaricin by Streptococcus salivarius isolated
from Malaysian subjects and its antimicrobial
activity. International Congress of the Malaysian
Society for Microbiology 2011
2
Abdul-Muhsin M Shami, Koshy Philip and
Sekaran Muniandy (2011). Antibacterial effect,
antioxidant potential and content of Phenolic
compounds in aqeous and ethanolic extracts of
plant mixture against selected microorganisms.
International Congress of the Malaysian Society
for Microbiology 2011
3
Crystal Engineering: Steric Bulk as a Design
Element - Implications for Luminescence and
Nanoparticle Generation, Departmental Seminar,
26 Apr 2011 to 26 Apr 2011, Department of
Chemistry, (University)
4
Emerging supramolecular synthons: Stabilisation
of crystal structures by C H.pi(chelate ring) and
by metal(lone pair).pi(aryl) interactions, Chemistry
Departmental seminar, 13 Oct 2011 to 13 Oct
2011, Department of Chemistry, (University)
5
Emerging supramolecular synthons: Stabilisation
of crystal structures by C H...pi(chelate ring)
and by metal(lone pair)...pi(aryl) interactions, 3rd
Asian Conference on Coordination Chemistry
(ACCC-3), 17 Oct 2011 to 17 Oct 2011,
Asian Coordination Chemistry Committee,
(International)
6
7
Foo Yoke Wai, Koshy Philip and Sekaran
Muniandy (2011). Isolation and Identification of
Lactobacillus with Antimicrobial Properties from
a Food Supplement. International Congress of
the Malaysian Society for Microbiology 2011
(Best Poster Award)
Goh Hweh Fen, Koshy Philip (2011). Isolation
and Identification of Lactic Acid Bacteria with
Antimicrobial Properties from Fermented
Food Products. International Congress of the
Malaysian Society for Microbiology 2011.
8
Helen-Ng LC, Razak IA, Ghani WMN,
Marhazlinda J, Norlida A, Zain RB. Dietary
consumption pattern and risk of oral cancer – a
Malaysia scenario. 3rd World Congress of the
International Academy of Oral Oncology, Yin and
Yang: Balancing Cure and Consequences, 14-17
July 2011, Grand Copthorne Waterfront Hotel,
Singapore. Oral Oncology Abstract no P98; pp
105.
9
Metal-thiolates: Novel Pharmaceutical Potential
of Gold and Bismuth against cancer, arthritis and
viral disease, Chemistry Department Seminar,
16 Nov 2011 to 16 Nov 2011, Department of
Chemistry, (University)
10 Nanogold and gold compounds pharmaceutical
applications, Bali International Seminar on
Science and Technology (BISSTECH 2011), 22
Jul 2011 to 23 Jul 2011, Prof. Putra Manuaba
(Udayana University), (International)
11 Bismuth: Non-toxic Compounds with Huge
Pharmaceutical Potential, Departmental Seminar,
17 Apr 2012 to 17 Apr 2012, Department of
Chemistry, (University)
12 Dazylah Darji and Yatimah Alias. Dissolution of
rubber biomass in ionic liquids. 17th Malaysian
Chemical Congress (17MCC) 2012, 15-17th Oct
2012, Putra World Trade Centre, Kuala Lumpur.
Poster.
13 Kumuthini Chandrasekaram, Sharifah Mohamad,
Hemavathy Surikumaran, Muggundha
Raoov, Tilagam Marimuthu and Puvaneswary
Subramaniam. Dicationic ionic liquid inclusion
with β-Cyclodextrin. 17th Malaysian Chemical
Congress (17MCC) 2012, 15-17th Oct 2012,
Putra World Trade Centre, Kuala Lumpur. Poster.
14 Ratnavelu, K (Ratnavelu, Kuru), Fatt, CK
(Fatt, Choong Kwai), Abu Ujum, E (Abu Ujum,
Ephrance), 2nd International Conference
of Mathematical Modelling and Scientific
Computation (ICMMSC 2012) Location:
Gandhigram, INDIA Date: MAR 16-18, 2012
MATHEMATICAL MODELLING AND SCIENTIFIC
COMPUTATION Book Series: Communications
in Computer and Information Science Volume:
283 Pages: 505-513 Published: 2012
15 Supramolecular Chemistry Based on Delocalised
Metal(lone pair) π(arene) Interactions: The Story
Thus Far, Cambodian Malaysian Chemical
Conference (CMCC) 2012, 19 Oct 2012 to 21
Oct 2012, Institut Kimia Malaysia & Cambodian
Chemical Society, (International)
16 Supramolecular Chemistry Based on Chelate
Rings Functioning as Donors and Acceptors,
17th Malaysian Chemical Congress (17MCC)
2012, 15 Oct 2012 to 17 Oct 2012, Institut Kimia
Malaysia, (National)
17 Supramolecular Synthons Based on Gold
pi(arene) Interactions, GOLD2012, 05 Sep
2012 to 08 Sep 2012, World Gold Council,
(International)
65
66
High Impact Research Annual Report 2012
18 Wan Melissa Diyana Wan Normazlan.
Physicochemical investigation of binary and
ternary mixtures of 1-ethyl-3-methylimidazolium
diethylphosphate (EMIM DEP), propanol and
water.17th Malaysian Chemical Congress
(17MCC) 2012, 15-17th Oct 2012, Putra World
Trade Centre, Kuala Lumpur. Poster.
19 Wan Melissa Diyana Wan Normazlan, Nor Asrina
Sairi and Yatimah Alias. Physicochemical
investigation of binary and ternary mixtures of
1-ethyl-3-methylimidazolium diethylphosphate
(EMIM DEP), propanol and water. 5th
Australasian Symposium on Ionic Liquids
(ASIL5), 3-4 May 2012, Monash University,
Australia. Poster.
7
FACULTY OF COMPUTER SCIENCE
INFORMATION & TECHNOLOGY
1
Rahman M. Z., A Combined Arithmetic Logic
Unit and Memory Element for the Design of a
Parallel Computer, Lecture Notes in Computer
Science, Vol. 7016/2011, pp. 306-317, October,
2011, doi:10.1007/978-3-642-24650-0_26.
2
K. Wong, S. Ong, and K. Tanaka. Improvement of
carrier capacity for scalable scrambling method
with reversible information insertion functionality.
IEEE Conference on Signal and Image
Processing Applications (ICSIPA), 16 - 18 Nov.
2011, Kuala Lumpur, Malaysia; pp. 312 – 317
3
KokSheik Wong, Simying Ong, Kiyoshi Tanaka
and Xiaojun Qi, “Bitstream Size Suppression
for DCT-based Information Hiding Method”,
IEEE International Symposium on Intelligent
Signal Processing and Communication Systems
(ISPACS), 7-9 Dec. 2011, Chiang Mai, Thailand;
pp. 1-5 (Best paper award)
4
S. Ong, K. Wong, and K. Tanaka, “Reversible
Data Embedding using Reflective Blocks with
Scalable Visual”, IEEE International Conference
on Intelligent Information Hiding and Multimedia
Signal Processing (IIH- MSP), 18-20 July 2012,
University of Piraeus, Greece; pp. 363 – 366
5
Muhammad Shiraz , Abdullah Gani, Rashid
Hafeez Khokar, Rajkumar Buyya A Review
on Application Processing Frameworks in
Mobile Devices for Mobile Cloud Computing
IEEE Communications Surveys and
Tutorials, IEEE (ACCEPTED, DOI: 10.1109/
SURV.2012.111412.00045, ISI Indexed Q1
(impact factor 6.3)).
6
Yiqi Tew and KokSheik Wong, “A Survey of
Information Hiding in H.264/AVC,” IIEEJ Proc.
Image Electronics and Visual Computing
Workshop 2012 (IEVC2012), 21-24 Nov. 2012,
Kuching, Malaysia; CD-ROM
FACULTY OF DENTISTRY
1
2
3
4
5
6
Cheong SC, IKN Chiang, KP Lim, CP Gan, KK
Sam, RB Zain, MT Abraham, WMW Mustafa,
ZAA Rahman. Establishment of in vitro Models
for Oral Cancer: Understanding How Key Genetic
Changes Drive Cancer for the Development
of Targeted Therapy. 6th APOCP: Clinical
Epidemiology and Practical Interventions - The
future of Cancer Control in Asia Pacific Region,
26th-29th April 2012, Pullman Kuching, Malaysia.
Abstract no FP 3.5; pp 75.
N.S. Abdullah, N.F.M. Radzali, R. Saub, R.D.
Vaithilingam. Oral Health-Related Quality Of
Life Of A Selected Malaysian Adult Population.
Europerio 7, 6-9 June 2012, Vienna, Austria. J
Clin Periodontol 2012 (ISI cited); Abstacts of
Europerio 7, P0276; pg 160.
Yong CC, John J, Koutronas E, Kallarakkal TG.
Cost estimation and planning for HIV/AIDS oral
healthcare services: a Malaysian experiment.
First International Science Symposium on HIV
and Infectious Diseases (HIV SCIENCE 2012)
Chennai, India. 20-22 January 2012. BMC
Infectious Diseases 2012, 12(Suppl 1):P93
DOI:10.1186/1471-2334-12-S1-P93
Joshi VK, John J, Esa R, Gomez MA, Kallarakkal
TG, Nambiar PK, Ramanathan A, Baharuddin
NA, Mani SA. Developing Empathy in Dental
Students. 21st Congress of the International
Association for Disability and Oral Health (IADH
2012) Melbourne, Australia. 28-31 October 2012.
Journal of Disability and Oral Health 2012, 13(3):
118
John J, Joshi VK, Esa R, Gomez MA, Kallarakkal
TG, Nambiar PK, Ramanathan A, Baharuddin NA,
Mani SA. Oral health care needs and OHRQoL
among prison inmates with HIV/AIDS – creating
a Community-Prison Link. 21st Congress of the
International Association for Disability and Oral
Health (IADH 2012) Melbourne, Australia. 28-31
October 2012. Journal of Disability and Oral
Health 2012, 13(3): 114
John J. Mobile Prosthodontist. 8th Biennial
Meeting of AAP and 40th Indian Prosthodontic
Society Conference (AAP-IPS 2012) Chennai,
India. 5-9 December 2012
Rosnah Binti Zain, Cheong Sok Ching, Vincent
Chong Vui King, Karen Ng Lee Peng. Harnessing
Genomic Information for Patient Benefit- The
Malaysian Oral Cancer Scenario. 10th AsiaPacific Conference on Human Genetics, Genetic
and Genomic Medicine: Working Together
Towards Health for All, 5th-8th December 2012,
Crowne Plaza Mutiara Hotel, Kuala Lumpur,
MALAYSIA.
CHANCELLORY
1
Loke Mun Fai, Khosravi Yalda, Nur Siti
Khadijah Ramli, The Xinsheng, Gunaletchumy
Selva Perumal, Goh Khean Lee and Vadivelu
Jamuna (2011) Interspecies Molecular
Crosstalk in Helicobacter Pylori infections. 2nd
International Student Conference on Microbial
Communication, 13 Sep 2011 to 16 Sep 2011
Jena, Germany
High Impact Research Annual Report 2012
2
Talkative bacteria: Can we stop them from chit
chatting?, Molecular Biology Seminar - AIMBN
Delegation to UM, 11 Apr 2011 to 11 Apr 2011,
UM Biotech Cluster, (International)
3
Detection of N−acyl homoserine lactone,
virulence factors and quorum quenching activity
from Potential Pathogen isolated from diseaseassociated Tilapia Fish,2nd International Student
Conference on Microbial Communication
(MiCom2011), 13 Sep 2011 to 16 Sep 2011,
Jena School of Microbial Communication,
(International)
4
Anti-quorum sensing properties of Melicope
lunu-ankenda, Piper nigrum, Piper betle
and Gnetum gnemon, The 2nd International
Conference on Atimicrobial Research- ICAR2012,
21 Nov 2012 to 23 Nov 2012, Formatex Research
Center, (International)
5
Ancient wisdom versus global antibiotic
resistance: Discovery of anti-quorum sensing
molecules as new hits and leads for next
generation anti-infective therapy, Central
European Symposium on Antimicrobials and
Antimicrobial Resistance, 23 Sep 2012 to 26
Sep 2012, Croatian Microbiological Society in
collaboration with Microbiological Societies from
Czech Republic, Slovakia, Hungary and Bosnia
and Herzegovina
6
7
8
9
High-throughput metagenomic analysis of the
microbial community at Ulu Slim Hot Spring,
Malaysia, The 17th Biological Sciences Graduate
Congress,08 Dec 2012 to 10 Dec 2012,
Chulalongkorn University, University of Singapore
(DBS-NUS) and the Malaya University.,
(International)
SP Gunaletchumy, JN Mason, A Saidin, XS Teh,
NSK Ramli, Y Khosravi1, MF Loke, HM Mitchell,
KL Goh, Vadivelu J. (2012) Whole genome
analysis of Helicobacter pylori. (2012) The 2nd
Asian Pacific topic conference Asian Pacific
Helicobacter pylori Meeting 2012, 13 Jan 2012
to 15 Jan 2012, Kuala Lumpur Malaysia
XS Teh, Y Khosravi, SP Gunaletchumy, NSK
Ramli, MF Loke, KL Goh, J Vadivelu. (2012)
Prevalence of Helicobacter pylori antibiotic
resistance pattern in Malaysia. The 2nd
Asian Pacific topic conference Asian Pacific
Helicobacter pylori Meeting 2012, 13 Jan 2012 to
15 Jan 2012, Kuala Lumpur Malaysia
Y Khosravi, SW Seow, XS Teh, NSK Ramli,
SP Gunaletchumy, MF Loke, RM Bunte, S
Pettersson , KL Goh, J Vadivelu. (2012) Gut
microbiota and Helicobacter pylori infections.
The 2nd Asian Pacific topic conference Asian
Pacific Helicobacter pylori Meeting 2012, 13 Jan
2012 to 15 Jan 2012, Kuala Lumpur Malaysia
10 Y Khosravi, XS Teh, SP Gunaletchumy, NSK
Ramli, MF Loke, KL Goh, J Vadivelu. (2012)
Interspecies molecular crosstalk in Helicobacter
pylori infection. The 2nd Asian Pacific topic
conference Asian Pacific Helicobacter pylori
Meeting 2012, 13 Jan 2012 to 15 Jan 2012,
Kuala Lumpur Malaysia
11 NSK Ramli, XS Teh, Y Khosravi, SP
Gunaletchumy, MF Loke, K Hardie, KL Goh,
J Vadivelu. (2012) Helicobacter pylori quorum
sensing in a multispecies consortium. The 2nd
Asian Pacific topic conference Asian Pacific
Helicobacter pylori Meeting 2012, 13 Jan 2012 to
15 Jan 2012, Kuala Lumpur Malaysia
12 Selva Perumal Gunaletchumy, Xinsheng Teh,
Yalda Khosravi, Nur Siti Khadijah Ramli, Eng
Guan Chua, Thevakumar Kavitha, Joanne N.
Mason, Huey Tyng Lee, Halimah Alias, Nur
Zafirah Zaidan, Norzawani Buang M. Yassin,
Liang Chung Tay, Stephen Rudd, Hazel
M.Mitchell, Nadeem O. Kaakoush, Mun Fai
Loke, Khean Lee Goh, and Jamuna Vadivelu
Genomic Structure and Diversity of Helicobacter
pylori Strains from Malaysia, 10th International
Workshop on pathogenesis and Host Response
in Helicobacter Infections, 04 Jul 2012 to 07 Jul
2012, European Study Group on Pathogenesis
and Immunology in Helicobacter Infections and
European Helicobacter Study Group (EHSG),
(International)
13 Puvaneswari M, Nur Aishah MT, Zamri
C, Nirmala BP, Ho GF, Yip CH,Kanga RS,
Kalanithi N. ocotrienols and Breast Cancer
– A Review ofRecent Findings. 6th General
Assembly Asian Pacific Organisation for Cancer
Prevention:Clinical Epidemiology and Practical
Interventions –the Future of Cancer Control in
the Asian Pacific Region. 26th-29th April 2012.
Pullman Hotel, Sarawak, Malaysia.
14 Hassan N, Mohd Taib NA, Yip CH, Teo SH, Yoon
SK, Thing MK. Risk of breast cancer in Malaysian
BRCA1 and BRCA2 carriers. Asia Pacific
Conference of Human Genetics, Genetic and
Genomic Medicine; Working Together Towards
Health for All, 5-8 December 2012. Crowne Plaza
Hotel, Kuala Lumpur. APCHG Abstract no 216
15 Hassan N. SNP profiling in determining risk
to breast cancer in Malaysia’s multi-ethnic
population. Working With the Human Genome
Sequence Workshop by Wellcome Trust Major
Overseas Programme, 3-6 December 2012,
Hospital for Tropical Diseases, Ho Chi Minh City,
Vietnam, pp v.
16 Rifhan Azwani M, Thong MK and Nur Aishah
Taib. Market Survey - Genetic Counseling (GC)
among Medical Practitioners and Students of
Faculty of Medicine, University of Malaya. 10th
Asia Pacific Conference on Human Genetics
(APCHG), 5th December - 8th December 2012,
Crown Plaza Hotel Kuala Lumpur, Malaysia.
Poster Presentation Abstract ID no:148.
17 Kwan-Hoong Ng. How useful is volumetric breast
density in predictiong breast cancer risk? 27th
Malaysia-SingaporeRadiographers’ Conference,
14 - 16 September 2012, Merdeka Palace Hotel
& Suite Kuching, Sarawak.
18 Kwan-Hoong Ng. How useful is volumetric breast
density in predictiong breast cancer risk? 10th
South East Asian Congress of Medical Physics,
The 12th Asia Ocenia Congress of Medical
67
68
High Impact Research Annual Report 2012
Physics, 11 -14 Disember 2012, Khum Phu
Come Hotel, Chiang Mai, Thailand.
19 Hassan N, Mohd Taib NA, Yip CH, Teo SH, Yoon
SK, Thing MK. Risk of breast cancer in Malaysian
BRCA1 and BRCA2 carriers. Asia Pacific
Conference of Human Genetics, Genetic and
Genomic Medicine; Working Together Towards
Health for All, 5-8 December 2012. Crowne Plaza
Hotel, Kuala Lumpur. APCHG Abstract no 216.
20 Liew YW, Ng KH, Abdul Aziz YF. Measuring
breast density from digital mammograms.
University of Malaya Research Imaging Centre
(UMRIC) Presentation, 26 April 2012.
21 Liew YW, Ng KH, Abdul Aziz YF. Breast density
quantification in UMMC. Breast density research
seminar, 20 February 2012.
22 EC Lee, Z Mohamed, SH Teo, NA Mohd Taib,
GF Ho, CH Yip. The effect of CYP2D6 genetic
polymorphisms on survival in Malaysian women
with ER positive breast cancer treated with
tamoxifen. 6th General Assembly Asian Pacific
Organization for Cancer Prevention, 26-29
April 2012, Pullman Hotel, Kuching, Sarawak,
Malaysia. PP16; page 105.
23 Phuah SY, Looi LM, Rhodes A, Dean S,
MohdTaib NA, Yip CH and Teo SH. Addition
of ER and PTEN, but not cytokeratins, aids
identification of BRCA1 carriers in Malaysian
breast cancer patients. AACR (American
Association for Cancer Research) Annual
Meeting, 31st March till 4th April 2012,
Mc.Cormick Place in Chicago, Illinois, USA.
Abstract no: 2609
24 Phuah SY, NA MohdTaib, Yip CH and Teo SH.
Prevalence of BRCA1 and BRCA2 mutations
among Malaysian breast cancer patients: Update
from the Malaysian Breast Cancer Genetic Study
(MyBrCa). Asia Pacific Conference of Human
Genetics, Genetic and Genomic Medicine;
Working Together Towards Health for All, 5-8
December 2012.Crowne Plaza Hotel, Kuala
Lumpur. Abstract no: 219
25 Phuah SY, Lee SY, Kang IN, Kang P, MohdTaib
NA, YIP CH and Teo SH. Prevalence of PALB2
(Partner and Localizer of BRCA2) mutation in the
Malaysian breast cancer genetic study (MyBrCa).
Asia Pacific Conference of Human Genetics,
Genetic and Genomic Medicine; Working
Together Towards Health for All, 5-8 December
2012.Crowne Plaza Hotel, Kuala Lumpur.
Abstract no: 217
26 Mariapun S, Phuah SY, Yip CH, MohdTaib NA,
Teo SH. Breast cancer risk factors in a Malaysian
cohort: A case control analysis. Annual
Scientific Congress of Malaysian Oncological
Society - Effective Cancer Treatment: Updating
Professionals, Educating the Public, 6th-9th
September 2012. Equatorial Hotel Melaka
27 Soo SS, Leong CO, Ng CH &Teo SH.
Combination of metformin and FEC
chemotherapy works synergistically on basal
breast cancer cell lines but not on cancer stem
cells. 6th General Assembly of Asia Pacific
Organisation for Cancer Prevention: Future of
Cancer Control, 26-29 April 2012, Pullman Hotel,
Kuching Sarawak. Poster Presentations no PP27;
pp 116.
28 Soo SS, Hassan N, Teh YC, Harun F, Yanan N,
MohdTaib NA, Yip CH, Teo SH. Association of
diabetes and tumour characteristics of breast
cancer in Malaysian breast cancer patients.
Annual Scientific Congress of Malaysian
Oncology Society: Effective Cancer Treatment:
Updating Professionals, Educating the Public,
6-9 September 2012, Equatorial Hotel Melaka,
Malacca. Poster Presentations no. 8.
29 Kang IN, Peter-Kang, Yip CH, MohdTaib NA,
Teo SH. A rapid and robust classification of
BRCA VUS in a case-control series using highthroughput Sequenom® platform increases
understanding of cancer risk in cancerpredisposed patients. Asia Pacific Conference
of Human Genetics, Genetic and Genomic
Medicine; Working Together Towards Health for
All, 5-8 December 2012.Crowne Plaza Hotel,
Kuala Lumpur. APCHG Abstract no 222.
30 Kang PCE, Kang IN, Sivanandan K, Thirthagiri E,
Phuah SY, Miao H, Hartman M, Yoon SY, Thong
MK, MohdTaib NA, Yip CH, Teo SH. BRCA1 &
BRCA2 Mutations in Malaysian Breast Cancer
Patients. Asia Pacific Conference on Human
Genetics 5- 8 Dec 2012, Crown Plaza Hotel,
Kuala Lumpur, Asia Pacific Conference on
Human Genetics (APCHG) abstract no. 229
31 K. D. Dambul, G. A. Mahdiraji, F. Amirkhan,
Desmond M. Chow, Gabriel K.W. Gan, W.R.
Wong, M.R. Abu Hassan, Sarahah Ismail, S.A.
Ibrahim, N. Tamchek and F.R. Mahamd Adikan
Fabrication and Development of Flat Fibers
Photonics Global Conference,singapore, 2012
32 D. M. Chow, D. C. Tee, S. R. Sandoghchi,
and F. R. Mahamd Adikan, “Direct UV Written
Waveguide’s Dispersion in Flexible Silica Flat
Fibre Chip,” in Specialty Optical Fibers, OSA
Technical Digest (online) (Optical Society of
America, 2012), paper SM2E.4. http://www.
opticsinfobase.org/abstract.cfm?URI=SOF-2012SM2E.4
33 Jahanshahi, P.; Ghomeishi, M.; Adikan,
F.R.M.; , “Adhesive layer effect on goldsilica thin film interfaces for surface plasmon
resonance modeling,” Photonics (ICP), 2012
IEEE 3rd International Conference on , vol.,
no., pp.89-92, 1-3 Oct. 2012 doi:10.1109/ICP
.2012.6379841 URL:http://ieeexplore.ieee.org/
stamp/stamp .jsp?tp=&arnumber=6379841
&isnumber=6379517
34 Yeo, K.S.; Chow, D.M.C.; Tee, D.C.; Wong,
W.R.; Sandoghchi, S.R.; Mahdi, M.A.; Adikan,
F.R.M.;, “Dispersion modeling of solid core
photonic crystal fiber,” Photonics (ICP), 2012
IEEE 3rd International Conference on , vol.,
no., pp.224-226, 1-3 Oct. 2012 doi: 10.1109/
ICP.2012.6379823 URL:http://ieeexplore.ieee.
org/stamp/stamp.jsp?tp=&arnumber=6379823&i
snumber=6379517
35 Chow, D.M.; Sandoghchi, S.R.; Adikan,
F.R.M.; “Fabrication of photonic crystal fibers,”
High Impact Research Annual Report 2012
Photonics (ICP), 2012 IEEE 3rd International
Conference on , vol., no., pp.227-230, 1-3 Oct.
2012 doi: 10.1109/ICP.2012.6379830 URL: http://
ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnum
ber=6379830&isnumber=6379517
36 Poh, A.H.; Adikan, F.R.M.; Bakar, M.H.A.; , “A
mounting method on configuring a wavelengthvoltage relation of an optical tunable bandpass
filter (TBF) for actuation & control,” Photonics
(ICP), 2012 IEEE 3rd International Conference
on , vol., no., pp.327-330, 1-3 Oct. 2012
doi: 10.1109/ICP.2012.6379833 URL: http://
ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnum
ber=6379833&isnumber=6379517
37 Hisham, H.K.; Abas, A.F.; Mahdiraji, G.A.; Mandi,
M.A.; Adikan, F.R.M.; , “Effect of temperature
and external optical feedback on intensity and
phase noise characteristics in single-mode fiber
grating Fabry-Perot laser,” Photonics (ICP), 2012
IEEE 3rd International Conference on , vol.,
no., pp.370-376, 1-3 Oct. 2012 doi: 10.1109/
ICP.2012.6379846 URL: http://ieeexplore.ieee.
org/stamp/stamp.jsp?tp=&arnumber=6379846&
isnumber=6379517
HIR 2 YEARS PROJECT - 2010
1
Alhoot MA and Sekaran SD (2010). RNA
interference inhibits dengue virus entry ang=d
multiplication into monocytes by silencing CD14 associated molecule. The 17th International
Student Congress of Medical Sciences (ISCOMS)
meeting in Groningen, The Netherlands.
2
Alhoot MA and Sekaran SD (2010). Inhibition
of dengue virus entry and multiplication into
monocytes by silencing CD-14 associated
molecule using RNA interference. Colloqium on
Updates on Dengue and Arbovirus Research in
Malaysia.
3
Alhoot MA and Sekaran SD (2010). Inhibition
of dengue virus entry and multiplication into
monocytes by silencing CD-14 associated
molecule using RNA interference. Colloqium on
Updates on Dengue and Arbovirus Research in
Malaysia. Appanna R, Lucy LSM, Wang SM and
Sekaran SD (2010). Cross-reactive T cells, HLA
Types, Cytokine Profiles and Endothelial Leakage
and Their Association in Dengue Infection.
Innovation & Creativity EXPO University of
Malaya.
4
Alhoot MA and Sekaran SD (2010). Silencing of
the CD-14 molecule on macrophages prevents
entry of dengue virus into monocytes. Innovation
& Creativity EXPO University 6f Malaya.
5
Appanna R, Lucy LSM, Wang SM and Sekaran
SD (2010). Cross-reactive T cells, HLA Types,
Cytokine Profiles and Endothelial Leakage and
Their Association in Dengue Infection. Innovation
& Creativity EXPO University of Malaya. Lee SK,
Fong MY and Sekaran SD(2010). Genetic of
Silent Infection in Dengue. Innovation & Creativity
EXPO University of Malaya.
6
Appanna R, Lucy LCS and Sekaran SD (2010).
Immunological Determinants and Associations
with Dengue Infections. Colloquium on Updates
on Dengue and Arbovirus Research in Malaysia
7
Chan SY, Sam IC, Chan YF. Replication kinetics
of Enterovirus 71 and Coxsackievirus A16 in
neuronal and intestinal cells. My1Bio conference,
Kuala Lumpur, 30-31 October, 2010.
8
Klekamp B, Mayer C, Appanna R, Komarasamy
TV, Rathakrishnan A, Lee SK, Cheong HC, Wang
SM, Azizan A, Sanhez-Anguiano A, Sathar J, and
Sekaran SD (2010). Immunilogical and genetic
profiles in the progression of dengue disease. 3rd
Annual Graduate Student Research
9
Lee SK, Fong MY and Sekaran SD(2010).
Genetic of Silent Infection in Dengue. Innovation
& Creativity EXPO University of Malaya.
10 Alhoot MA and Sekaran SD (2010). Silencing of
the CD-14 molecule on macrophages prevents
entry of dengue virus into monocytes. Innovation
& Creativity EXPO University of Malaya.
11 PMMA-LiBOB Gel Electrolyte for lithium Ion
Batteries, XII International Symposium on
Polymer Electrolytes, (ISPE 12), Padova, Italy, 29
August - 3 September 2010.
12 Pilban S, Zak AK, Abd Majid WH, Muhamad
MR. Synthesis and Characterization of Lead
Calcium Titanate Nanocomposite. Malaysia
Annual Physics Conference 27-30 Oct
2010 (PERFIK-2010), Damai Laut, Malaysia.
AIP Conf. Proc. Vol.1328 pp. 183-185.
DOI:10.1063/1.3573723
13 Chan YF. Phylogenetic designation of
EV71 genotypes and subgenotypes. The
1st International Symposium of Vaccine
Development against Human Hand-Foot-andMouth Diseases. 4-5 September 2011, Zhunan,
Taiwan. (Invited speaker).
14 Chan YF. Enterovirus 71: a decade later. 9th
Biennial Convention of the Asean Neurological
Associaiton (ASNA): Neuroinfection symposium.
2- 5 November, 2011. (Invited speaker)
15 Chan SY, Sam IC, Chan YF. Differential Proteome
analysis of human colon adenocarcinoma cells
infected with enterovirus 71 and coxsackievirus
A16. 1st International Symposium of Infectious
Diseases and Signal Transduction Research. 1920 November 2011, Tainan, Taiwan. (Poster)
16 Chiam CW, Chan YF, Ong KC, Wong KT, Sam IC.
Neurovirulence variation of different Chikungunya
virus genotypes in ICR suckling mice. 16th
Biological Sciences Graduate Congress, 1214th December 2011, National University of
Singapore, Singapore.
17 C.H. Lim and C.S. Chan. A Framework on Fuzzy
Intrusion Detection. International Workshop
on Advanced Computational Intelligence and
Intelligent Informatics, 19-23 November 2011,
Suzhou, China.
18 Choo, Y. M. “Malaysian Terrestrial Plants and
Microorganisms: Source of New Leads”, The
6th International Conference on Cutting-Edge
69
70
High Impact Research Annual Report 2012
Organic Chemistry in Asia 11-15 December 2011
Hong Kong
methymethacrylate”, presented at Malaysia
Polymer International Conference, 18 – 20 Oct
2011, Bangi, Selangor, (selected to be published
in Jurnal Sains Malaysiana).
19 Helen-Ng LC, Razak IA, Ghani WMN,
Marhazlinda J, Norlida A, Zain RB. Dietary
consumption pattern and risk of oral cancer – a
Malaysia scenario. 3rd World Congress of the
International Academy of Oral Oncology, Yin and
Yang: Balancing Cure and Consequences, 14-17
July 2011, Grand Copthorne Waterfront Hotel,
Singapore. Oral Oncology Abstract no P98; pp
105.
29 Tan CW, Chan YF, Tan EL, Sim KM, Poh CL.
Inhibition of enterovirus 71 infections by a novel
peptide derived from enterovirus 71 capsid
protein VP1. 1st International Symposium of
Infectious Diseases and Signal Transduction
Research. 19-20 November 2011, Tainan,
Taiwan. (Poster)
20 K.B.Md Isa, L.Othman, M.Mansor and Z.Osman,
“Ionic Conductivity And Transference Number
Studies of PVDF-HFP/PMMA – (EC+PC) Gel
Polymer Electrolytes Containing Lithium Salt”,
presented at Malaysia Polymer International
Conference, 18 – 20 Oct 2011, Bangi, Selangor,
(selected to be published in Jurnal Sains
Malaysiana).
30 Y.H. Kong, S.N. Syed Zanaruddin, W.M.N. Ghani,
Z.A. Abdul Rahman, M.T. Abraham, R. Anand,
S.H. Lau, R.B. Zain and Sok Ching Cheong.
Expressions of EMT markers are associated with
pattern of invasion in oral cancer. 4th Regional
Conference on Molecular Medicine, 9 - 11
October 2011, G-Hotel, Gurney Drive, Penang,
Malaysia. RCMM Absract no OP11, pg. 35
21 K.H. Thung, P. Raveendran, Similarity Measure
of Moment Vectors as Image Quality Measures,”
IVCNZ 2011, Twenty-sixth International
Conference Image and Vision Computing, 29
Nov - 1 Dec, 2011, Auckland, New Zealand.
31 Yeo GN, Woon KL. Influence of Series
Resistance, Shunt Resistance and Interface
Properties on Fill Factor of P3HT/PCBM Organic
Photovoltaic- 26th Regional Conference on
Solid State Science and Technology 2011, 22-24
November 2011, The Royale Bintang Seremban,
Negeri Sembilan, Malaysia. RCSSST Abstract no
C10.
22 L.Othman, S.M.Samin, N.H.Zainol, K.B.Md Isa
and Z.Osman, “Lithium Ion Conduction Studies
of Gel Polymer Electrolytes Based on PMMA”,
presented at Malaysia Polymer International
Conference, 18 – 20 Oct 2011, Bangi, Selangor.
23 M.A. Freeman, A. Horák, M. Eydal, P. Keeling
2011. X-cell parasites of Atlantic cod are basal
dinoflagellates.Oral presentation: VI European
Congress of Protistology (ECOP VI). Berlin,
Germany 25th-29th July.M.A. Freeman, A. Horák,
M. Eydal, P. Keeling 2011. X-cell parasites of
Atlantic cod are basal dinoflagellates.
24 M.I.M.Ghazali, L.Othman, K.B.Md Isa and
Z.Osman, “Ionic Conductivity and Structural
Studies of PMMA+EC+PC+LiBF4 Gel Polymer
Electrolytes”, presented at Malaysia Polymer
International Conference, 18 – 20 Oct 2011,
Bangi, Selangor, (selected to be published in
Jurnal Sains Malaysiana).
25 K.H. Thung, P. Raveendran, Similarity Measure
of Moment Vectors as Image Quality Measures,”
IVCNZ 2011, Twenty-sixth International
Conference Image and Vision Computing, 29
Nov - 1 Dec, 2011, Auckland, New Zealand.
26 Razali R, Zak AK, W. H. Abd. Majid, M. Darroudi,
Solvothermal synthesis of microsphere ZnO
nanostructures in DEA media, International
Symposium on Advanced Materials for Optics
Microelectronics ana Nanoelectronics AMOMEN
27-30 Oct 2011, Ibn Tofail University, Kenitra,
Morocco.
27 Romano Ngui, Yvonne AL Lim, Rebecca Traub,
Rohela Mahmud, Mohd Sani Mistam. Molecular
characterization of hookworms from human and
domestic carnivores in rural areas of Malaysia.
Joint International Tropical Medicine Meeting
(JITMM), Bangkok, Thailand. 1-2nd December
2011. (Oral).
28 S.M.Samin, K.B.Md. Isa, L.Othman
and Z.Osman, “Li-Ion conduction and
Structural Studies of GPE based on Poly
32 Zak AK, Abd Majid WH, Gan WC. Experimental
and Theoretical Dielectric Studies of PVDF/
PZT Nanocomposite Thin Films, International
Symposium on Advanced Materials for Optics
Microelectronics and Nanoelectronics AMOMEN
27-30 Oct 2011, Ibn Tofail University, Kenitra,
Morocco.
33 Z.Osman, M.F.Zulkifli, K.B.Md Isa and L.Othman,
“Preparation and Characterization of Gel Polymer
Electrolytes Based on PVDF-HFP/PMMA Blend”,
presented at Malaysia Polymer International
Conference, 18 – 20 Oct 2011, Bangi, Selangor.
34 Yeo Adeline, Wang SM, Sekaran SD (2012).
Comparison of neutralizing antibodies of dengue
patients with their asymptomatic household
members. 9th Asia Pacific Congress of Medical
Virology in Adelaide, Australia.
35 Rathakrishnan A and Sekaran SD (2012). The
presentation was entitled : Dengue specific
HLA-restricted T-Cell Response and Cytokine
Profiling of Dengue Patients in Malaysia. 9th Asia
Pacific Congress of Medical Virology in Adelaide,
Australia.
36 Rathakrishnan A and Sekaran SD (2012). The
presentation was entitled : Dengue specific
HLA-restricted T-Cell Response and Cytokine
Profiling of Dengue Patients in Malaysia. 9th Asia
Pacific Congress of Medical Virology in Adelaide,
Australia.
37 Frontiers in Polymers, Lyon 29-31 May 2011
Effect of fillers on ionic conductivity of PANbased gel and composite electrolytes for
possible applications in lithium batteries, XIII
International Symposium on Polymer Electrolytes
(ISPE 13), Iceland (26-31 August 2012).
38 Yeo Adeline, Wang SM, Sekaran SD (2012).
Comparison of neutralizing antibodies of dengue
patients with their asymptomatic household
High Impact Research Annual Report 2012
members. 9th Asia Pacific Congress of Medical
Virology in Adelaide, Australia.
39 Effect of fillers on ionic conductivity of PANbased gel and composite electrolytes for
possible applications in lithium batteries, XIII
International Symposium on Polymer Electrolytes
(ISPE 13), Iceland (26-31 August 2012).
40 N.H. Zainol and Z. Osman, “Studies of Ionic
Transport and Morphological Properties of
PMMA-Gel Polymer Electrolytes Containing
Magnesium Ions”, presented at International
Conference of Young Researchers on Advanced
Materials, 1 – 6 July 2012, Singapore.
41 Siti Mariam Samin, Lisani Othman, Khairul
Bahiyah Md Isa, Mazwan Mansor and Zurina
Osman, “Effect of PVDF-HFP on Ionic
Conductivity, Structural and Morphological
Studies in PMMA/PVDF-HFP Blend Gel
Polymer Electrolytes”, presented at International
Conference of Young Researchers on Advanced
Materials, 1 – 6 July 2012, Singapore.
Biotechnology 2012. 30 October, 2012 University
Malaya. (Young Investigator awarded to student
Tan Chee Wah)
48 Chiam CW, Loong SK, Chan YF, Sam IC.
Development of strand-specific quantitative realtime polymerase chain reaction for Chikungunya
virus. 9th Asia-Pacific Congress of Medical
Virology, 6-8th June 2012, Adelaide Convention
Centre, Australia.
49 Musa S and Govindasamy V. Dental Pulp Stem
Cells – Its Characteristics and Therapeutic
Potential. Programme and abstract book of BIT’s
5th World Congress of Regenerative Medicine
and Stem Cells 2012, 2-4 Disember 2012,
Guangzhou, China. Oral presentation. Abstract
pp. 165.
50 Lim, C.K. and Chan, C.S. Fuzzy Set and
Multi Description Property. IEEE International
Conference on Fuzzy Systems (IEEE World
Congress on Computational Intelligence), 10 -15
June, 2012, Brisbane, Australia, pp. 1-8.
42 N. H. Zainol, Z. Osman and L. Othman,
“Transport and Morphological Properties of Gel
Polymer Electrolytes Containing Mg(CF3SO3)2”
– presented at International Materials Technology
Conference and Exhibition, 9 – 12 July 2012,
Sunway Resort Hotel and SPA, Selangor.
51 Lim, C.H. and Chan, C.S. A Fuzzy Qualitative
Approach for Scene Classification. IEEE
International Conference on Fuzzy Systems
(IEEE World Congress on Computational
Intelligence),10-15 June 2012, Brisbane,
Australia, pp. 1-8.
43 Z. Osman, K. B. Md Isa and L. Othman, “Ion
Transport and Morphological Properties of Gel
Polymer Electrolytes Based on PVDF-HFP”
– presented at International Confererence on
Materials Science and Technology, Kottayam,
India, 10-14 June 2012.
52 Guan Ni Yeo; Kai Lin Woon, Electrical Tunable
Open Circuit Photovoltages From Polarization
Enhanced Organic Photovoltaic Cells, ICSSST
, 18-20 Dec 2012, Holiday Inn, Melacca
Copthorne Waterfront Hotel, Singapore. Oral
Oncology Abstract no P98; pp 105.
44 L. Othman, K. B. Md Isa, Z. Osman and R.
Yahya, “Ionic Conductivity, Morphology and
Transport Number of Lithium Ion in PMMA Based
Gel Polymer Electrolytes”, presented at 8th
International Conference on Diffusion in Solids
and Liquids 2012, Istanbul, Turkey, 25-29 June
2012.
53 Abd Majid WH. Thin film composite and their
potential application. 8th Mathematica and
Physica Science Graduate Congress (8th
MPSGC), 8-10 Dec 2012 Chulalongkorn
University, Bangkok, Thailand.
45 VK Vincent-Chong, WMW Mustafa, Y-H Yang, A
Arif, LP Karen-Ng, ZAA Rahman, SK Cheong, SM
Ismail, PP Jayaprasad, ZM Zaini, N Prepageran,
TG Kallarakkal, A Ramanathan, Y Hasmawati,
MRN Shielawati, MT Abraham, KK Tay, RB
Zain. Deletion of chromosome 20p13 in oral
squamous cell carcinoma (OSCC) is associated
with better overall survival of patients. 6th
General Assembly Asian Pacific Organisation for
Cancer Prevention, “Clinical Epidemiology and
Practical Interventions – the Future of Cancer
Control in the Asian Pacific Region”, 26-29 April
2012, Pullman Hotel Kuching Sarawak Malaysia.
APOCP Absract no FP3.3 pp 73
46 Chan YF. Inhibition of enterovirus 71 infections
by a novel peptide derived from enterovirus
71 capsid protein VP1. 7th National Infectious
Diseases and Seminar and Workshop, 6
November 2012, University Putra Malaysia.
(Invited speaker)
47 Tan CW, Sam IC, Poh CL, Chan YF. Enterovirus
71 uses cell surface heparan sulfate
glycosaminoglycan as an attachment receptor.
Malaysian Society of Molecular Biology and
54 Velayutham TS, Ng BK, Gan WC, Abd. Majid
WH, Hashim R, Heidelberg T. Dielectric and
pyroelectric properties of glycolipid (C14-10G2).
The 8th Asian Meeting on Electro Ceramics. 1-5
July 2012 Penang, Malaysia.
55 Gan WC, Abd Majid WH, Furukawa T. Structural
and Electrical Properties of Polar Alpha
Poly(vinylidene fluoride) Thin Films. International
Symposium on Integrated Functionalities (ISIF
2012),18-21 Jun 2012 di Hong Kong Polytechnic
University, China. ISIF Abstract Book; pp 367.
56 Yap, A. C., Chan, K. G., and Choo, Y. M.
“The Study of Secondary Metabolites from
Proteobacteria”, The 7th International
Conference on Cutting-Edge Organic Chemistry
in Asia 11-14 December 2012 Nanyang
Technology University, Singapore
57 Ngui R, Lim YAL, Liam CK, Chow SC and Shukri
J. Association between anaemia, iron deficiency
anaemia, neglected parasitic infections and
socioeconomic factors in rural children of
West Malaysia. 48th Annual Conference of the
Malaysian Parasitology and Tropical Medicine
(MSPTM). Infectious Disease in a Borderless
World. Grand Seasons Hotel, Kuala Lumpur. 2728 March 2012. (Poster).
71
72
High Impact Research Annual Report 2012
HIR 2 YEARS PROJECT - 2011
1
Heng PL, Lee CW (2010) Production and loss
rate of phototrophic picoplankton in tropical
coastal waters. In: My1Bio, 8−10 October 2010,
Berjaya Times Square, Kuala Lumpur (poster
presentation)
2
Lim JH, Lee CW (2010) Phytoplankton
productivity and mortality in tropical coastal
waters. In: 15th Biological Science Graduate
Congress, 15−17 December 2010, University
of Malaya, Kuala Lumpur, Malaysia (poster
presentation)
3
Abdullah, N.L., Mohd.-Zin, S.W., Mohammed,
R.S., Pai, Y.J., Patrick, J.E., Thong, M.K., Marret,
M., Aminah, A., Greene, N.D.E., Copp, A.J.,
Ahmad-Annuar, A., & Abdul-Aziz., N.M. The
implications of Eph and ephrin signalling in neural
tube closure. 2011 Neuroscience Symposium. 12
to 13 December 2011. NeuroMalaysia Society
(Javan spitting cobra) venom and the effect
of a neurotoxic polyvalent antivenom. Paper
presented at the 17th Congress of the European
Section of the International Society of Toxinology,
Sep 11th-15th, 2011. Valencia, Spain
11 Abdullah, N.L., Mohd.-Zin, S.W., Mohammed,
R.S., Pai, Y.J., Patrick, J.E., Thong, M.K., Marret,
M., Aminah, A., Greene, N.D.E., Copp, A.J.,
Ahmad-Annuar, A., & Abdul-Aziz., N.M. Is the
leading edge of neurulation an asymmetrical
lamellipodia-like structure emanating from the
surface ectoderm and whether this mirrors
the human spina bifida condition? 19 to 29
September 2012. UCL, KCL, and NIMR at
London, United Kingdom.
12 Abdullah, N.L., Mohd.-Zin, S.W., Mohammed,
R.S., Pai, Y.J., Patrick, J.E., Thong, M.K.,
Marret, M., Aminah, A., Greene, N.D.E.,
Copp, A.J., Ahmad-Annuar, A., & Abdul-Aziz.,
N.M. Overcoming Spina Bifida – Personally,
Experimentally and Clinically. Program Majlis
Suai Kenal Beserta Ceramah Dan Kaji Selidik
Spina Bifida. 3 November 2012. Spina Bifida
Association of Malaysia.
4
Evaluation of The Antioxidant Activity In Lignosus
SPP., Malaysian Society of Biochemistry and
Molecular Biology Annual Conference, Eastin
Hotel , Petaling Jaya, 27-28 August 2011
5
Helen-Ng LC, Razak IA, Ghani WMN,
Marhazlinda J, Norlida A, Zain RB. Dietary
consumption pattern and risk of oral cancer – a
Malaysia scenario. 3rd World Congress of the
International Academy of Oral Oncology, Yin and
Yang: Balancing Cure and Consequences, 14-17
July 2011, Grand Copthorne Waterfront Hotel,
Singapore. Oral Oncology Abstract no P98; pp
105.
6
Leong, P.K., Fung, S.Y., Sim, S.M. and Tan, N.H.
(2011). Cross neutralization of some Southeast
Asian cobra and krait venoms by Indian
polyvalent antivenoms. Paper presented at the
17th Congress of the European Section of the
International Society of Toxinology, Sep 11th15th, 2011. Valencia, Spain
14 Abdullah, N.L., Mohd.-Zin, S.W., Mohammed,
R.S., Pai, Y.J., Patrick, J.E., Thong, M.K., Marret,
M., Aminah, A., Greene, N.D.E., Copp, A.J.,
Ahmad-Annuar, A., & Abdul-Aziz., N.M. Adhesion
and Fusion of the Spinal Neural Tube. Monthly
Neuroscience Seminar Series 2012, Universiti
Putra Malaysia. 25 April 2012. Neuroscience
Research Cluster Monthly Seminar Series.
7
Pre-Commercialization of \’Cendawan Susu
Harimau\’ (Lignosus Rhinocerus), International
Invention , Innovation & Technology Exhibition
(ITEX 2011), Kuala Lumpur, malaysia, 20-22 may
2011 (Gold medalist; Special Award Prix de salon
de geneva )
15 Lim JH and Lee CW (2012) Seasonal dynamics
of phytoplankton production and loss rates
in tropical coastal waters. In: 17th Biological
Science Graduate Congress, 8-10 December
2012, Chulalongkorn University, Bangkok,
Thailand. (oral presentation)
8
Tiger Milk Mushroom (Lignosus rhinocerus):
Nutritional Content and Assessment Of Its Safety
By Histological Examination of Vital Organs of
Rats Fed With The Sclerotial Powder, Malaysian
Society of Biochemistry and Molecular Biology
Annual Conference, Eastin Hotel , Petaling Jaya,
27-28 August 2011
9
W. S. Chiu, S. A. Rahman, P. S. Khiew, T. K. Tan,
S. Radiman, R. Abd-Shukor, M. A. Abd. Hamid,
C. H. Chia, Time-Dependent Characterizations
on Size Distribution of Fe3O4 Nanocrystals by
Using Transmission Electron Microscope, 20th
Scientific Conference of Microscopy Society
of Malaysia & Extraordinary General Meeting,
2011, Permaisuri Resort, Port Dickson (Oral
Presentation)
16 Abdullah, N.L., Mohd.-Zin, S.W., Mohammed,
R.S., Pai, Y.J., Patrick, J.E., Thong, M.K.,
Marret, M., Aminah, A., Greene, N.D.E.,
Copp, A.J., Ahmad-Annuar, A., & Abdul-Aziz.,
N.M. Overcoming Spina Bifida – Personally,
Experimentally and Clinically. Annual General
Meeting of the Spina Bifida Association of
Malaysia this Saturday. 14 April 2012. Spina
Bifida Association of Malaysia.
10 Yap, M.K.K., Tan, N.H., Sim, S.M. and Fung,
S.Y. (2011) Pharmacokinetics of Naja sputatrix
13 Abdullah, N.L., Mohd.-Zin, S.W., Mohammed,
R.S., Pai, Y.J., Patrick, J.E., Thong, M.K.,
Marret, M., Aminah, A., Greene, N.D.E.,
Copp, A.J., Ahmad-Annuar, A., & Abdul-Aziz.,
N.M. Overcoming Spina bifida - Personally,
Experimentally and Clinically. International
Neuroscience Symposium. 23-25 July 2012.
Universiti Malaysia Sabah and Brain Research
Initiative Monash University (BRIMS)
17 Lim JH and Lee CW (2012) Seasonal dynamics
of phytoplankton production and loss rate in
tropical coastal waters. In: SCS 2012 Sharing
knowledge, resources and technologies for a
sustainable South China Sea. 21-24 October
2012, University of Malaya, Malaysia. (poster
presentation)
High Impact Research Annual Report 2012
18 Heng PL and Lee CW (2012) Potential production
and loss rates of picocyanobacteria in tropical
coastal waters. In: SCS 2012 Sharing knowledge,
resources and technologies for a sustainable
South China Sea. 21-24 October 2012, University
of Malaya, Malaysia. (poster presentation)
19 Noraishah M. Abdul-Aziz, Mohammed R. Shaker,
Aminah Abdullah & Nicholas D.E. Greene.
Recent Advances in Prevention of Neural Tube
Defects. 10th Asia-Pacific Conference on Human
Genetics 2012. 5 – 8 December 2012.
20 Design and Rational for the Postoperative
Vascular Events in Unrecognized Obstructive
Sleep Apnea Trial. Edwin Seet, Matthew Chan,
CY Wang, Stanley Tham, Frances Chung,
Society of Anesthesia Sleep Medicine Annual
Conference October 11-12, Washington, D.C ,
2012. Best Clinical Research Presentation:First
Prize Winner.
21 Discovery of a new Tiger Milk Mushroom Species
from Malaysia, Lignosus cameronensis, ISMS 18,
Beijing, China, 26-29 August 2012, pp 28
22 Breathing new life to a malaysian lost national
treasure - the tiger milk mushroom (Lignosus
rhinocerotis), ISMS 18, Beijing, China, 26-29
August 2012, OR1-2, pp7
23 Evaluations of the potential teratogenic and
anti-fertility effects of lignosus rhinocerus (tiger
milk mushroom) in rats, ISMS 18, Beijing, China,
26-29 August 2012, pp 170
24 Evaluation of antioxidant activity of Lignosus
rhinocerus ( Tiger Milk Mushroom) sclerotia,
ISMS 18, Beijing, China, 26-29 August 2012, P66, pp151
25 Anti-inflammatory activity of Lignosus rhinocerus
(tiger milk mushroom), ISMS 18, Beijing, China,
26-29 August 2012, P6-5, pp150
26 Anti-proliferative activity of Tiger Milk Mushroom
(Lignosus rhinocerus) and gene expression
alterations of MCF-7 Breast cancer cells induced
by treatment with the mushroom extract, ISMS
18, Beijing, China, 26-29 August 2012, P6-4,
pp149
27 Molecular Phylogeny of Lignosus rhinocerus (
Tiger Milk Mushroom) based on complete 18S
and 28S ribosomal DNA sequences, ISMS 18,
Beijing, China, 26-29 , August 2012, P3-3, pp81
28 A.Z.S.Zulkifli, M.A.Kamarudin, A.Mainal,
S.M.Said. NMR investigationof order parameter
of liquid crtstal embedded in polivinyl alcoholbased polymer electrolytes. 4th International
Conference of Solid State Science and
Technology, ICSSST2012, 18-20 December,
Holiday Inn Malacca, Malaysia.
29 M.A.Kamarudin,A.Z.S.Zulkifli, A.Mainal,S.M.Said.
New liquid crystal-embedded polyvinyl alcoholbased polymer electrolyte for improved optical.
4th International Conference of Solid State
Science and Technology, ICSSST2012,18-20
December, Holiday Inn Malacca, Malaysia.
30 N.A.A.M.Amin, D.A.A.Shnawah, M.F.M.Sabri,
S.M.Said. Electrical Resitivity of Low Cost, High
Reliability Element-added Lead-free Solder. 4th
International Conference of Solid State Science
and Technology, ICSSST2012,18-20 December,
Holiday Inn Malacca, Malaysia.
31 M.A.Rahman, I.Yamana, G.Y.Yeap, S.M.Said, M.
Kimura. Electro-optic potential of room and high
temperature polymer stabilised blue phase liquid
crystal. 4th International Conference of Solid
State Science and Technology, ICSSST2012, 1820 December, Holiday Inn, Malacca, Malaysia.
32 W.S.Chiu, E.K.Chiew, S.X. Too, S. N. H. Daud,
S. A. Rahman, A. Suhaimi Bakar, Z. Aspanut,
P.S. Khiew, T.K. Tan, S. Radiman, R. AbdShukor, M. A. A. Hamid, C. H. Chia. Structural
Characterization of Iron Oxide (Fe3O4) Magnetic
Nanocrystals Prepared by Green Chemistry
Approach, International Solid State Science &
Technology, 2012, Holiday Inn Hotel, Melaka
(Poster Presentation)
33 Chai H.K., Yorikawa M., Momoki S. and Terazawa
M., “Damage assessment of fiber-reinforced
concrete beams by stress wave velocity
distribution”, The Fourth Asia-Pacific Young
Researchers and Graduates Symposium, Hong
Kong, Dec 2012, pg. 10-15 (Received Best Paper
Award)
34 Kang YL, Ibrahim S, Saravanan P. Performance
of Microbial Fuel Cell Inoculated with Mixed
Culture from Anaerobic Lagoon. 7th Deans’
Meeting and Students’ Conference of the AsiaOceania Top University League in Engineering,
Embracing New Horizons of Education and
Innovation in Engineering and Technology, 24-25
November 2012, University of Malaya, Malaysia.
Abstract no 160; pp 160.
35 Vythilingam, I. Plasmodium knowlesi Malaria in
humans: An emerging public health problem.
First International Congress on Tropical Medicine
& Infectious Diseases. 4-7 December 2012.
Impiana Hotel, Ipoh, Perak. Symposium11,pp31.
2. Vythilingam I. Ecology of malaria vectors and
their Plasmodium parasites in Malaysia. XXIV
International Congress of Entomology.20-24 Aug.
EXCO, Daegu, Korea. Symposium1308, F01.
pp110
36 Abu-Shariah M. Geoelectrical Resistivity
Imaging Technique for Detecting Subterranean
Cavity, International Conference on the Geology
of the Arabian Plate and the Oman Mountains
(ICGAPOM) 7- 9 January 2012 , Saltuan Qaboos
University, Oman. Abstract Volume, pp6.
37 Shatirah Akib, Afshin Jahangirzadeh, Babak
Kamali and Noor Liana Mamat, Sea Level Rise
and Implication on Coastal Process: A Review.
ASME 2012 31st International Conference
on Ocean, Offshore and Arctic Engineering
OMAE2012, July 1-6, 2012, Rio de Janeiro,
Brazil.
38 Shatirah Akib, Afshin Jahangirzadeh, Lim
Hong Wei, Sharif Moniruzzaman Shirazi, Sadia
Rahman, “Experimental study on the skewed
integral bridge by using crushed concrete
geobags as scour protection”, 6th International
Conference on Scour and Erosion ICSE 6, Aug
27-31, 2012, Paris, France.
73
74
High Impact Research Annual Report 2012
39 Afshin Jahangirzadeh, Shatirah Akib, Zubaidah
Ismaill, Babak Kamali, Mahshid Kakouei, Arash
Behnia, “Determination of Rectangular Collar
Dimensions for Reducing Scour around Bridge
Pier”, 6th International Conference on Scour and
Erosion ICSE 6, Paris, France, Aug 27-31, 2012
40 Jahangirzadeh. A., Akib. S., Kamali. B., Rahman.
S., Optimal water allocation: sustainable
management of dam reservoir, International
Conference on Architectural, Civil and
Environmental Engineering. Paris, November, 2012
41 Kakouei, M., Kakouei, M., Subramanian, K.,
Musa Kahn, S., Jahangirzadeh, A., Akib, S.,
Masouleh: A City; A History, International
Conference on Architectural, Civil and
Environmental Engineering. Paris, November,
2012
42 Shatirah Akib, Nazirah Mashodi, Afshin
Jahangirzadeh and S.M. Shirazi, “Semi-Integral
Bridge Scour Countermeasure Using Gabion
and Crushed Concrete Mixed with Palm Shell:
A Review”, 5th ASEAN Civil Engineering
Conference (ACEC), Ho Chi Minh, Vietnam, Oct
25-26, 2012
43 Prevathe Poniah, Zahurin Mohamed, Ivy Chung,
Shanggar Kuppusamy, Azad Hassan Abdul
Razack. Ethnic differences in prostate-specific
antigen levels as indicator of disease severity
in prostate cancer among Malaysians. 26th
Scientific Meeting of Malaysian Society of
Pharmacology & Physiology. 18-20 May 2012.
Penang.
LIST OF SUCCESSFUL APPLICANTS 2012
(HIR Projects – 2 Years)
No.
Faculty
Principal Investigator (PI)
Target output
No. of Tier 1
ISI-Indexed
Publications
International
Collaborations
1
Faculty of Medicine
Assoc. Prof. Ong Teng Aik
5
4
2
Faculty of Science
Prof. Dr. Muhammad Mazhar
6
0
3
FCSIT
Dr. Hamid Abdulla Jalab
2
0
4
Faculty of Medicine
Prof. Dr. Ng Kee Peng
3
0
5
Faculty of Medicine
Dr. Wong Won Fen
3
3
6
Faculty of Medicine
Dr. Esakimuthu Shankar
3
2
7
Faculty of Science
Dr. Masatoshi Sone
5
3
8
Faculty of Engineering
Assoc. Prof. Dr. Zubaidah Ismail
2
1
9
Faculty of Medicine
Dr. Noraishah Mydin Haji Abdul Aziz
8
1
10
Faculty of Science
Prof. Dr. Wan Ahmad Tajuddin Wan Abdullah
10
1
11
Faculty of Built
Enviroment
Prof. Dr. Hamzah Abdul Rahman
2
0
12
Faculty of Science
Prof. Dr. Hapipah Mohd Ali
8
1
High Impact Research Annual Report 2012
LIST OF SUCCESSFUL APPLICANTS 2012
(HIR-MoHE Projects – 4 Years)
No.
Faculty
Principal Investigator (PI)
Target output
No. of Tier 1
ISI-Indexed
Publications
International
Collaborations
1
Faculty of Medicine
Dr. Lau Yee Ling
32
NA
2
Faculty of Medicine
Associate Profesor Dr. Visvaraja Subrayan
15
NA
3
Faculty of Medicine
Profesor Dr. Shamala Devi A/P Sekaran
4
Faculty of Medicine
Prof. Dr. Tunku Kamarul Zaman Tunku Zainol
Abidin
5
Faculty of Medicine
6
Faculty of Engineering
7
8
9
2
NA
NA
Profesor Dr. Mohd Rais Mustafa
3
2
Professor Dr. Saad Mekhilef
28
2
Faculty of Engineering
Professor Ir. Dr. Mohd Azlan Bin Hussain
15
3
Faculty of Engineering
Prof. Dr. A.S.M.A Haseeb
20
NA
9
Faculty of Engineering
Prof. Dr. Mohd Hamdi Abd Shukor
30
1
10
Faculty of Engineering
Dr. Lim Einly
15
3
11
Faculty of Engineering
Prof. Dr. Imtiaz Ahmed Chowdhury
27
3
12
Faculty of Engineering
Dr. Suhana Mohd Said
21
1
13
Faculty of Engineering
Dr. Brahim Si Ali
10
1
14
Faculty of Engineering
Assoc. Prof. Dr. Shamsuddin Ahmed
Mohammed Shahadat
12
2
15
Faculty of Engineering
Prof. Dr. Nasarudin Abd Rahim
30
1
16
Faculty of Engineering
Dr. Judha Purbalaksono
15
NA
17
Faculty of Engineering
Prof. Dr. Roslan Hashim
30
1
18
Faculty of Engineering
Assoc. Prof. Dr. Siti Zawiah Md. Dawal
15
4
19
Faculty of Engineering
Prof. Ir. Dr. Mohd Zamin Jumaat
29
1
20
Faculty of Engineering
Assoc. Prof. Ir. Dr. Abdul Aziz Abdul Raman
30
1
21
Faculty of Engineering
Assoc. Prof. Ir. Dr. Abdul Aziz Abdul Raman
40
1
22
Faculty of Engineering
Dr. Ahmad Khairi Abdul Wahab
30
1
23
Faculty of Engineering
Assoc. Prof. Dr. Saidur Rahman Abdul Hakim
26
1
24
Faculty of Engineering
Mr. Norhafizan Ahmad
24
1
25
Faculty of Engineering
Prof. Dr. Raveendran Paramesran
22
2
26
Faculty of Engineering
Prof. Dr. Mohamed Kheireddine Taieb Aroua
8
NA
27
Faculty of Engineering
Professor Ir. Dr. Wan Abu Bakar Wan Abas
57
2
28
Faculty of Engineering
Dr.Kazi Md. Salim Newaz
10
2
29
Faculty of Engineering
Dr. Ahmad Badarudin Mohamad Badry
10
2
30
Faculty of Engineering
Assoc. Prof. Dr. Lam Wei Haur
20
4
31
Faculty of Engineering
Dr. Hazlee Azil Illias
20
1
32
Faculty of Engineering
Assoc. Prof. Dr. Faisal Rafiq Mahamd Adikan
NA
NA
33
Faculty of Dentistry
Assoc. Prof. Dr. Chen Yeng
7
1
34
Faculty of Dentistry
Prof. Ian Paterson
12
3
35
Faculty of Dentistry
Dr. Chew Hooi Pin
5
1
36
Faculty of Dentistry
Assoc. Prof. Dr. Roslan Saub
2
1
37
Faculty of Dentistry
Dr. Siti Adibah Othman
5
1
38
Faculty of Dentistry
Assoc. Prof. Dr. Hadijah Abdullah
8
NA
39
Faculty of Dentistry
Assoc. Prof. Dr. Fathilah Abdul Razak
4
NA
40
Faculty of Dentistry
Assoc. Prof. Dr. Marina Mohd. Bakri
3
1
75
76
High Impact Research Annual Report 2012
No.
Faculty
Principal Investigator (PI)
Target output
No. of Tier 1
ISI-Indexed
Publications
International
Collaborations
41
Faculty of Dentistry
Dr Wan Himratul Aznita Binti Wan Harun
3
NA
42
Faculty of Dentistry
Dr. Nor Himazian Mohamed
3
NA
43
Faculty of Dentistry
Prof Dr Phrabhakaran Nambiar
4
NA
44
Faculty of Dentistry
Assoc. Prof. Dr. Chen Yeng
3
NA
45
Faculty of Dentistry
Assoc. Prof. Dr. Zamri Radzi
35
1
46
FCSIT
Dr. Chan Chee Seng
5
2
47
FCSIT
Dr. Rafidah Md Noor
3
2
48
FCSIT
Prof. Dr. Loo Chu Kiong
10
4
49
FCSIT
Assoc. Prof. Dr. Abrizah Abdullah
3
NA
50
FCSIT
Assoc. Prof. Dr. Miss Laiha Mat Kiah
4
NA
51
FCSIT
Prof. Dr. Lee Sai Peck
3
NA
52
Faculty of Science
Emeritus Profesor Dr. Yong Hoi Sen
11
NA
53
Faculty of Medicine
Profesor Dr. Vickneswaran Mathaneswaran
20
1
* FCSIT – Faculty of Computer Science and Information Technology
RESEARCH PROPOSALS 2012
•
•
•
•
•
•
HIR 2 years HIR-MoHE (Medicine) HIR-MoHE (Engineering)
HIR-MoHE (Dentistry) HIR-MoHE (Computer Science & Information Technology)
HIR-MoHE (Chancellory)
78
High Impact Research Annual Report 2012
RESEARCH PROPOSALS
(HIR 2 Years)
Project No: UM.C/625/1/HIR/130
Title: Large-scale Profiling of Cancer/Testis Antigens
(CTA) and the Delineation of MiRNA-mediated Reversal
of CTA-associated Aberrant Demethylation in Urothelial
Cell Carcinoma
Principal Investigator: Assoc. Prof. Ong Teng Aik
Department: Surgery
Faculty: Medicine
Summary of Research Proposal
In Malaysia, bladder cancer is the 6th most common cancer amongst males.
Among that, over 75% of patients are initially diagnosed with superficial
tumours. The 5-year survival rates de-creases with the degree of tumour
invasiveness and the presence of metastasis.
Cancer/testis antigens (CTAs) are usually restricted to the testis in the normal
adult, but are aberrantly expressed in several types of cancers. Because of
their restricted expression pattern, the CTAs represent attractive biomarker
candidates for cancer diagnosis/prognosis.Apart from building the capacity
to profile CTA expression, we are interested in investigating the potential of
a specific CTA KDM5B as a therapeutic target. We have previously profiled
a cohort of UCC tissues and identified several CTAs to be located in regions
of high CNV as well as amongst top dysregulated genes in high risk UCC.
The deregulation of KDM5B has already been reported in majority of human
cancers.Thus identifying the ‘switch’ that abates the expression of KDM5B
would accelerate the development of effective therapies to eradicate entire
population of cancer cells including the cancer stem cells or tumourinitiating cells named as microRNA(MiRNA). MiRNAs are small endogenous
molecules that play substantial roles in human development and cell lineage
decisions. As the fundamental regulator of these physiologically significant
cellular processes, aberrant expressions of miRNAs are expected to
contribute to the development of various human diseases, including cancer.
It is based on evidences that the expression of KDM5B in embryonic stem
cells are regulated by microRNAs (miRNAs) and expression of some miRNAs
are altered in UCC, that we suggest miRNAs as a potentially potent regulator
of KDM5B
Objectives
1.
To establish CTA protein expression and localisation patterns in UCC
tissues of dif-ferent stages, grades, clinical outcomes and ethnic
groups.
2.
To assess the correlation between individual and/or combination of CTA
expression and:
•
clinical stage and grade (superficial vs muscle invasive disease)
•
recurrence risk in individuals with superficial disease
•
disease progression (superficial to invasive disease transition)
3.
To identify miRNAs (antagomirs) that target KDM5B in UCC
4.
To determine the effect of KDM5B-targeting miRNAs on aberrant
histone methyla-tion profiles in UCC, especially in CSC subpopulations
High Impact Research Annual Report 2012
Methodology
Outcome
Current Progress
This project aims to consolidate
the existing multi-disciplinary local
expertise with world-reknowned
clinical and scientific academics
from University of Cambridge,
Johns Hopkins University and
University College London to
jumpstart bladder cancer research
in the region. The project will
be a catalyst for future highimpact research projects that will
establish Malaysia in the global
research map against bladder
cancer. Nevertheless, this project
will also produce the following
expected results and benefits:
1.
Ethics approval from UMMC
and Ministry of Health
2.
Sample collection
3.
Optimization of IHC
techniques
•
•
CTA profiles are predictive
of tumour recurrent and
invasive potential and
suggesting as prognostic
biomarkers for recurrence
or progression to invasive
disease.
Specific miRNAs that abate
the expression of oncogenic
CTA reverses the abberant
histone methylation profiles
in bladder cancer stem
cells; could be used as a
therapeutic antagomir that
can act as an adjuvant
therapeutic to reduce risk of
recurrence.
Collaborators
Prof Dr Azad Hassan bin
Abdul Razack, Dr. Retnagowri
Rajandram, Dr. Jasmine Lim,
Department of Surgery, University
of Malaya, Malaysia.
Prof Datuk Dr Looi Lai Meng,
Department of Pathology,
University of Malaya, Malaysia.
Asst Prof Dr Abhimanyu
Veerakumarasivam, Perdana
University Graduate School of
Medicine, Malaysia & Universiti
Putra Malaysia.
Prof Dr David Neal, Department
of Oncology, University of
Cambridge, UK
Prof Dr John Kelly, Division of
Surgery & Interventional Science,
UCL Medical School, University
College London.
Prof Dr Robert H. Getzenberg,
James Buchanan Brady Urological
Institue, Johns Hopkins University
School of Medicine, USA.
Assoc. Prof. Dr. Edmund Sim Ui
Hang, Department of Molecular
Biology, Faculty of Re-source
Science & Technology, Universiti
Malaysia Sarawak.
Dr Murali Sundram, Hospital Kuala
Lumpur, Malaysia
Dr Teh Guan Chou, Consultant
Urologist, Head of Department
Department of Urology, Hospital
Umum Sarawak.
Dr. Jamil Dol Kadir, Consultant
Urologist,Head and Senior
Consultant Pathologist,Hospital
Umum Sarawak.
Dr Chan Soon Choy, Perdana
University Graduate School of
Medicine, Malaysia.
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/131
Title: Development of Advanced Ceramics Thin Films
From Single Source Precursor by AACVD for Solar Cell
Technology
Principal Investigator: Professor. Dr. Muhammad Mazhar
Department: Chemistry
Faculty: Science
Summary of Research Proposal
Advanced ceramics poised of versatile elemental combinations include
metal oxides, metal car-bides, and metal nitrides reveal a wide range of
properties that have found its way for novel cat-alytic, sensors, structural,
electrical, electronic, magnetic, and biomaterials applications. The ceramics
thin-film fabricated by using physical techniques suffer from multiple
drawbacks such as poor conformality, low throughput, restricted directional
variation, and low compositional con-trol. These adverse effects make these
thin films less useful for making devices. Therefore, our research features
for the fabrication of advanced ceramics thin films through an inexpensive
Aerosol Assisted Chemical Vapour Deposition (AACVD) based on single
source molecular pre-cursors (SSP) technique that is particularly valuable to
fabricate thin films in a single step with controlled stoichiometry, uniformity,
morphology and improved optical properties with applica-tions in alternative
energy and electronics fields. AACVD technology is a rather recent method
to gain favor in the processing of advanced ceramics thin films offering
extensive advantages.
Objectives
The specific objectives of this
research project are
1.
Designing of specifically
tailored novel metal organic
precursors.
2.
Fabrication of advanced
ceramic oxide/ sulphide thin
films using new precursors.
3.
Investigation of properties
of thin films for solar cell
applications.
Outcome
Advanced ceramics thin
films fabricated by this work
can be employeed in field of
electronics, solid oxide fuel cells,
photoelectrochemical splitting of
water for production of hydrogen
and hydrogen storage materials.
Possible High Impact Journals
for Publications
1.
Chemical Vapour Deposition
2.
Inorganic Chimica Acta
3.
Dalton Transction
4.
Thin Solid Films
5.
Inorganic Chemistry
Collaborators
Dr. K.G. Upul Wijayantha,
Loughborough University, United
Kingdom
Dr. Asif Ali Tahir, University of
Liverpool, United Kingdom
Project No: UM.C/625/HIR/132
Title: A Robust Method For Copy- Forgery Detection In
Digital Images.
Principal Investigator: Hamid Abdulla Jalab
Department: Computer System & Technology
Faculty: Computer Science & Information Technology
Summary of Research Proposal
Tampering the digital images in a way that it’s impossible to be detected by
naked eyes has become easier with development of image editing tools.
Copy-move forgery is one of the frequently used and important techniques
to hide or manipulate the content of the image. It happens by coping one
part of the image and pastes it to another part of the same image to cover
an important object. Consequently, this research is intended to propose an
efficient method for Copy-move forgery detection in digital images using
singular value decomposition technique which is able to authenticate the
High Impact Research Annual Report 2012
digital image and detect the tamper locations accurately. The authentication method
will be worked on gray-scale and RGB images. Finally, implementation of research
outcomes proposed by this study can be used as powerful digital image forensic tool
to authenticate the digital image along with locating the exact locations of tampers.
Objectives
Methodology
Outcome
1.
To investigate on existing
Copy-Move forgery detection
methods.
2.
To implement a new efficient
copy-move detection
technique with high tamper
detection rate
3.
To improve the accuracy of
the detection rate.
Develop a new efficient copymove detection technique with
high tamper detection rate, which
can be used as powerful digital
image forensic tool to authenticate
the digital image along with
locating the exact locations of
tampers.
4.
To assess the accuracy of
detection percentage of
proposed method compared
to oth-ers.
Requirement analysis phase is
the first step of the project which
is consists of evaluating the
existed technique that we are
going to investigate and improve.
The comparison between
differ-ent techniques of tamper
detection will be conducted in
Literature review of the project.
The proposed detection system
works based on Singular value
decomposition, it is a valuable
meth-od and has been used
in a lot of fields such as image
processing, image compression,
data analysis, signal processing
and weather prediction. It
presents a suitable way for cutting
off a matrix to get useful data
about the image, and shows
a factorization for all matrices.
The pro-posed prototype will
be implemented using MATLAB
which is a high performance
language that consist of variety
of tool box. In testing phase of
project different attacks will be
performed in order to prove the
efficiency of proposed copy-move
detection system.
Possible High Impact Journals
for Publications
1.
Journal of Computer and
System Sciences
2.
IEEE Transactions on
Computers
3.
Journal of Systems and
Software
4.
Journal SIGNAL
PROCESSING
5.
Journal of Real-Time Image
Processing
Collaborators
Dr. Ali Elkateeb . Department
of Electrical and Computer
Engineering at University of
Michigan, Dearborn, USA . e-mail:
[email protected]
Project No: UM.C/625/1/HIR/134
Title: An Integrated Morphological, Evolutionary
Genomics and Genome Characterization of Clinical and
Economical Significant Dematiaceous Fungi
Principal Investigator: Professor Dr. Ng Kee Peng
Department: Medical Microbiology
Faculty: Medicine
Summary of Research Proposal
Dematiaceous fungi are typically soil saprophytes, plant pathogens, and
contaminants living in the hospital and laboratory environment. They are
common indoor allergens causing hay fever or hypersensitivity reactions in
susceptible individuals that sometime could lead to acute exacerbation of
asthma and cause opportunistic infections in immunocompromised AIDS
patients.
The current lack of familiarity of dematiaceous infection among the clinicians
and lab personnel coupled with inadequate sensitivity and specificity
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High Impact Research Annual Report 2012
tests have contributed to the diffi-culties of clinical isolates identification.
This research project is based on the research outputs and novel findings
from the first project supported by HIR (UM.C/625/1/HIR/004, Project
Title: Cultural and genomics characterization of dematiaceous fungi
isolated in Malaysia). The com-plete phenotypic, taxanomic and genome
characterization of three fungal genera from the study may lead these
isolated strains to become the medical reference strains and genome
sequences for all future comparison analysis. Findings from the analysis of
these fungal genome sequences will serve as important platform to develop
downstream clinical and pharmaceutical applications that is critical in
exploiting the utility of fungal traits and improving healthcare management.
Objectives
Methodology
Outcome
This research aim to study
morphological and evolution
genomics of new dematiaceous
fungi isolated from the UM’s
Mycology Laboratory and
generation of 10 draft genome
sequenc-es from the isolates.
An Integrated Fungal Genome
Database and Genome Browser
will be de-veloped which served
as a platform for accumulation
and retainment of knowledge,
standardiza-tion of data and;
create a platform for local and
international collaboration. Lastly,
we aim to elucidate the functional
complexity of fungal genomes via
whole transcriptome sequencing
ap-proach.
The black molds reference
strains to be used in this study
will be selected among the 112
dematiaceous fungi isolated in
UMMC from previous study. New
isolates from the clinical and nonclinical specimens will be included
in this study. Increase numbers of
previously uncharacterized fungi
among different phylogenetic
classes for genome sequencing
in this study will enhance the
knowledge on diversity and
conserved traits among the
dematiaceous fungus.
1.
Generation of draft genomes
of dematiaceous fungi
2.
Identified genes associated
with the virulence
and transformation of
enviromental saprophytic
fungi to fungi associated with
human diseases.
Possible High Impact Journals
for Publications
PLos ONE , BMC Genomics,
Eukaryotic Cells, Genome
Research, Genomics
Collaborators
Yap Thai Leong (PhD), Laboratory
of Molecular Biophysics, National
Heart, Lung, and Blood Institute,
National Institutes of Health,
Bethesda, 208013, USA
Project No: UM.C/625/1/HIR/ 136
Title: Investigation of function and transcriptional
regulatorymechanism of Runx1 molecule in early B
lymphocyte development
Principal Investigator: Wong Won Fen
Department: Department of Medical Microbiology
Faculty: Faculty of Medicine
Summary of Research Proposal
B lineage lymphocyte development involves series of processes including
heavy and light chain VDJ rearrangement, pre-B cell receptor (BCR)
formation and selection. Impairment of B cell development can cause B
lineage-acute lymphoblastic leukemia (B-ALL) and agammaglobulinemia
immunodeficiency disease. One of the main cause for B-ALL is
chromosomal translocation t(8,21) which leads to lost-of-function mutation
in gene encoding Runx1. Runx1 is a member of Runt family transcription
factor that plays an essential role in definitive hematopoiesis and T
lymphocyte differentiation. We previously found that the expression level of
High Impact Research Annual Report 2012
Runx1 in B lymphocytes is high, implying a potential role for Runx1 in the
controlling B cell developmental or functional program. However, at present,
the role of Runx1 in regulating B cell development is poorly understood.
Objectives
In this study, we would like
to investigate Runx1’s role in
the regulation of early B cell
development and immune
response.
Methodology
We will first examine the
expression pattern of Runx1 at
different developmental stages
including pro-, pre-, immature and
mature B cells in bone marrow
or in spleen. Following this, we
will prepare conditional knock
out mice with specific deletion
of Runx1 in B cells. Propotional
changes in the B cells versus
other hematopoietic cells in bone
marrow, lymphoid organs or in
circulation will be measured.
Important processes during early
B cells development such as VDJ
recombination, cell apoptosis and
B cell receptor (BCR) formation
will be studied intensively between
control and Runx1 deficient mice.
Finally, we will infect the mice
with pathogen such as H1N1
influenza virus and evaluate a
potential defect in plasma B cell
differentiation and immunoglobulin
secretion capability due to lost of
Runx1.
Possible High Impact Journals
for Publications
Nature Immunology
Collaborators
Masanobu Satake, Tohoku
University, Japan.
Kazuyoshi Kohu, National
University of Singapore, Singapore
Outcome
This study is important for
understanding of B cell lineage
commitment, which outcome may
contribute to a solution for B-ALL
or agammaglobulin disease.
Project No: UM.C/625/1/HIR/139
Title: Mechanisms of T cell dysfunctions in hepatitis C
infection
Principal Investigator: Assoc. Prof. Dr Shankar Esaki Muthu
Department: Department of Medical Microbiology
Faculty: Faculty of Medicine
Summary of Research Proposal
Hepatitis C virus (HCV) is a positive-sense single-stranded RNA virus that
has been estimated to affect ~170 million people worldwide. About 70%
of the infected individuals clear the virus spontaneously during the acute
phase of infection whereas ~30% of individuals progress to chronic phase
that eventually culminates in cirrhosis and hepatocellular carcinoma (HCC).
Functional exhaustion/immunosenescence which leading to immune
dysfunction of T cells is also the hallmark of other persistent viral infections
(PVIs) exemplified by hepatitis B virus (HBV) and HIV infections in human. A
number of genes have been found to be upregulated or downregulated in
exhausted T cells in HCV, suggesting a role for inhibitory molecules. These
molecules reportedly facilitate HCV persistence in the host. Probe, LAG-3,
TRAIL, BLIMP-1, FoxP3, PD-1, TIM-3, CTLA-4, and secreted indoleamine
2, 3 dioxygenase (IDO) are some of the most widely investigated inhibitory
molecules in PVIs (especially murine LCMV infection) that were identified
to be overexpressed in functionally impaired T cells. In the proposed
investigation, these various inhibitory molecules/receptors that are
potentially associated with immune dysregulation with HCV infection, and
the immunopathophysiological mechanisms underlying their upregulation
are likely to be addressed.
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High Impact Research Annual Report 2012
Objectives
Methodology
We aim to investigate the
expression of numerous inhibitory
and functional molecules
up-regulated and/or downregulated in exhausted CD4+
and CD8+ effector and central
memory T cells and myeloid
dendritic cells of HCV infection.
In this sectional, we also aim to
investigate the transcriptional cell
signaling pathways regulating the
expression of inhibitory molecules
in T cells that regulate expansion
and restoration of HCV-specific T
cells during chronic HCV infection.
Numerous inhibitory molecules/
receptors that are involved in
immune dysregulation in HCV
in-fection will be studied to
describe the mechanism to get a
detailed picture of key regulator
of early antiviral responses
that determines whether an
infection is resolved rapidly
progresses to chronic infection.
A comprehensive study will be
conducted through proteomics
approaches with support of
available immunological resources
and softwares. Final validation
will be conducted via molecular
approaches to underpin the
association of suppressor
molecules with HCV-associated
immune exhaustion.
Outcome
Possible High Impact Journals
for Publications
European Journal of Immunology,
Journal of Immunology , Molecular
Medicine, PLoS ONE
Collaborators
Marie Larsson, Linköping
Universitet, Sweden.
Karlhans Fru Che, Karolinska
Institutet, Solna, Stockholm,
Sweden.
Vijayakumar Velu, Emory
University, Atlanta, USA.
Shukkur Muhammed Farooq,
Wayne State University, USA .
Subhadra Nandakumar, Centers
For Disease Control, Atlanta, USA.
Understanding the precise
mechanisms whereby HCV
recruits immune regulatory
components that lead to
progression of chronic HCV would
lead to development of novel
avenues of transla-tional research
to treat or improve the quality of
life of HCV infected individuals.
Project No: UM.C/625/1/HIR/140
Title: Zircon U-Pb geochronology for sedimentary
Provenance, magnetism, and tectonic evolution of
Malaysia and adjacent regions
Principal Investigator: Associate Professor Dr. Masatoshi Sone
Department: Geology
Faculty: Science
Summary of Research Proposal
Today, a 1/4 of all high-impact researches in Geoscience deal more or less
with zircon U-Pb geochronology. Zircon is a radioactive mineral that forms
principally in cooled magma and can remain as detrital grains over billion
years of Earth history. It can indicate fair accurate ages of igneous and
metamorphic rocks and can be used for identifying provenance (source) of
sedi-mentary rocks. This can be applied to tectonic reconstruction and basin
evolution of SE Asia terranes. For example, the core of SE Asia consists of
two tectonic blocks, Sibumasu and Indo-china, which have been separated
from Gondwana at different times, but their locations in Gondwana are not
clearly understood. Zircon geochronology may reveal their origins, and it will
help us better understand the tectonic evolution of SE Asia.
High Impact Research Annual Report 2012
Objectives
1.
2.
3.
Determine the most plausible
location of Sibumasu in
Gondwana;
Determine provenance of
SE Asian sedimentary rocks,
e.g., Gondwana origin of
the Cambrian Machinchang
Formation in Langkawi
Geopark, and linkage of
Mesozoic fluvial sediment
between Indochina and
Malaysia;
Tectonostratigraphic
correlation among different
terrains in SE Asia.
to collect data for U-Pb ages
and Hf isotope. The data will be
analysed to determine zircon
age populations and modes
and Hf affinity for crustal and
mantle sources. The results will
be compared with other parts
of Asia-Australia to confirm if
there are any similarities and/or
dissimilarities in zircon properties.
Other sedimentological,
geochemical and petrological
analyses will be carried out in UM.
Outcome
1.
Gondwana origin of SE Asian
terranes;
Methodology
2.
Samples of sedimentary, igneous
and metamorphic rocks will be
collected from targeted formations of SE Asia. Zircon grains
will first be separated at Academia
Sinica, Beijing. Then, the zircon
will be examined at LA-ICP-MS
lab of National Taiwan University
Provenance linkage of
sedimentary rocks between
Indochina and Malaysia
(e.g. the Tembeling Group in
Taman Negara);
3.
Late PalaeozoicMesozoic stratigraphy,
palaeogeography and
tectonic evolution of SE Asia
Possible High Impact Journals
for Publications
Geology; Gondwana Research;
Journal of Asian Earth Sciences;
International Journal of Earth
Sciences
Collaborators
Sun-Lin Chung, Hao-Yang Lee
(National Taiwan University); Mike
Searle (Oxford); Satoshi Tanaka
(Kyoto University of Education);
Toshifumi Komatsu (Kumamoto
Univer-sity);
Kamal Shuib, Azman Abdul Ghani
(UM)
Project No: UM.C/625/1/HIR/141
Title: Experimental and Numerical Investigation on
Tsunami Acting On Cable Stayed Bridges
Principal Investigator: Associate Prof. Dr. Zubaidah Binti Ismail
Department: Civil Engineering
Faculty: Engineering
Summary of Research Proposal
Two tragic tsunamis that devastated the west coast of Sumatra Island,
Indonesia in 2004 and North East Japan in 2011 had damaged bridges to
various extents. Due to the increasing popularity of cable stayed bridges,
it is vital that more attention be paid to the effects of tsunamis on this
type of bridge. In order to understand the tsunami force on cable stayed
bridges, experimental tests will be carried out to study the characteristics of
hydrodynamic force at different wave heights. The fluid structure interaction
between the cable stayed bridge and tsunami for numerical model based on
finite element analysis by LS-DYNA will be conducted. Numerical models of
tsunami impact on the bridge superstructures will be developed.
Objectives
The objectives of this research
can be summarized as follows:
1.
Identify mechanism of wave
propagation around cable
stayed bridge;
2.
Evaluate the physical
phenomena of tsunami force
on cable and deck of cable
stayed bridge;
3.
Conduct experimental tests
to determine the distribution
of hydrodynamic, impulsive,
buoyant and uplift forces on
cable stayed bridge due to
tsunami; and
4.
Validate the experimental
analysis by simulating using
numerical and computation
anal-ysis.
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High Impact Research Annual Report 2012
Methodology
This study includes experimental
study in National Hydraulic
Research Institute of Malaysia
and Hydraulic Laboratory of
University of Malaya and also
computational and numerical
modelling for validation purposes.
The second Penang Bridge will
be modelled on 1:100 scale in a
40m long hydraulic flume with a
cross section of 1.25m by 1m. The
model dimension is 47cm long,
30cm wide and 10cm high. A high
frequency load cell with 6 degrees
of freedom will be mounted at
the base of the model to record
the tsunami forces. A bi-linear
pressure profile is proposed for
determining the maximum tsunami
force acting on the model. An
accelerometer is installed at
the top of the bridge model
with the purpose of estimating
the time history of the bridge’s
acceleration. A numerical model
based on finite element code by
LS-DYNA will be used to simulate
the laboratory model subject to
hydrodynamic loads of tsunami
to estimate load and tension
distribution of the bridge model
Possible High Impact Journals
for Publications
1.
Journal of Engineering
Structures
2.
Journal of Coastal
Engineering
3.
Journal of Hydraulic
Engineering
Outcome
Numerical and experimental study
of tsunami wave loading on a
cable stayed bridge can produce valuable understanding on
characteristics of wave loading
and identified mechanism of wave
propagation and tsunami load
distribution around the bridge
superstructure. There are many
gaps in the studies on tsunami
wave on bridge superstructure
and this proposal aims to
improve the understanding of
the characteristics of tsunami on
bridge superstructures.
Collaborators
Professor Dr. Hashim Abdul
Razak, Department of Civil
Engineering, Faculty of Engineering, University of Malaya,
Malaysia
Dr Zainah Ibrahim, Department
of Civil Engineering, Faculty of
Engineering, University of Malaya,
Malaysia.
Professor Dr. Yozo FUJINO,
Department of Civil Engineering,
University of Tokyo, Ja-pan
Project No: UM.C/625/1/HIR/148/2
Title: Elucidation of the mechanism and rescue of the
Human Neural Tube Defects gene(s)
Principal Investigator: Dr. Noraishah Mydin Abdul Aziz
Department: Parasitology
Faculty: Medicine
Summary of Research Proposal
We have constructed the EphA2 EphA4 double heterozygotes which exhibits
38% spina bifida and 6% exencephaly. We are currently using the EphA2
EphA4 double heterozygotes embryos to further understand the role of
ultrastructures. Electron microscopy studies on these embryos have shown
an explosion of apoptotic cells on the surface of the unfused neural tube.
Rescue experiments using the black seed oil is also currently underway
using the EphA2 EphA4 double heterozygotes as models. Furthermore, we
have identified 2 potential NTD causative genes in the human spina bifida
population via exome analysis.
Objectives
1.
To assess the possibility that
EphA2 and EphA4 may be
candidates for human neural
tube defects.
2.
To identify other potential
variant genes causing
Spina bifida in Malaysian
population.
3.
To investigate the activities of
BSO on the NTDs in EphA2
and EphA4 compound
mu-tants and compound
heterozygotes
4.
To rescue MEKK4 using BSO
5.
To assess the possibility that
BSO may be a candidate for
a new preventive NTDs supplement alongside folate and
inositol in humans.
High Impact Research Annual Report 2012
Methodology
1.
Case Selection
2.
Gene expression analysis of
the EphA2 and EphA4 genes
in human Neural tube defect
cases
3.
Identification of causal genes
in humans with neural tube
defects
4.
Rescue experiments with
black seed oil (BSO), Mice,
food preparation, feeding
and measurement on MEKK4
5.
Generation and dissection
of homozygous embryos by
crossing the heterozygous
mice, Analysis of progeny
6.
TUNEL Assays, Cell
Proliferation Assay (BrdU
Analysis)
7.
Preservation and Analysis of
ultra-structure at posterior
and anterior neuropore of
the spinal neural tube using
electron microscopy
8.
Adhesion and fusion of
spinal neural folds occur
asymmetrically and are
mediated by EphA2 and
EphA4 receptor tyrosine
kinase – Nature (To be
submitted December 2013)
9.
3.
Maternal intake of dietary
virgin coconut oil modifies
fatty acids causing low
birth weight and spiky fur in
mice – PloS Medicine (To be
submitted June 2013)
10. Gastrochisis in the
EphA2/EphA4 compound
heterozygotes due to failure
of adhesion and fusion –
PloS One (To be submitted
June 2014)
4.
Consequences of nutritional
oils during pregnancy – what
is safe and what is not ?
– Na-ture Medicine (To be
submitted December 2013)
5.
6.
Molecular study
Outcome
Possible High Impact Journals
for Publications
1.
2.
Pai YJ, Abdullah NL, Mohd.Zin SW, Mohammed RS,
Rolo A, Greene ND, AbdulAziz NM, Copp AJ. Epithelial
Fusion during Neural Tube
Morphogenesis (2012). Birth
Defects Res A Clin Mol
Teratol. 2012 Oct;94(10):81723. doi: 10.1002/bdra.23072.
Epub 2012 Sep 3.
Essential fatty acids profile
of black seed oil from Yemen
show marked differences in
comparison to black seed
oil from other regions of the
world – TALANTA (submitted
No-vember 2012)
Black Seed Oil rescues
Folate and Inositol-Resistant
Neural Tube Defects – Nature
(To be submitted December
2014)
7.
Essential fatty acids of black
seed oil is neurulationspecific and promotes neural
tube closure – Proceedings
of the National Academy
of Sciences USA (To be
submitted De-cember 2013)
8.
Exome sequencing and
functional analysis identifies
human EPHA2 and EPHA4
as the cause of neural tube
defects - Proceedings of
the National Academy
of Sciences USA (To be
submitted December 2014)
Targeted capture and
massively parallel
sequencing of 3 triad family
exomes of non syndromic
Neural Tube Defects – PloS
One (To be submitted
December 2014)
Collaborators
Dr Azlina Ahmad-Annuar, Faculty
of Medicine, UM.
Prof Thong Meow Keong, Faculty
of Medicine, UM.
Assoc Prof Mary Joseph Marret,
Faculty of Medicine, UM.
Dr Julia Patrick Engkasan, Faculty
of Medicine, UM.
Dato’ Prof. Dr. Zaliha Omar
Prof. Dr. Aminah Abdullah
Dr Nicholas Daniel Edward
Greene, Neural Development Unit,
Institute of Child Health, University
College London
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/149
Title: Quantum chromodynamics jet studies at the
CERNLarge Hadron Collider (LHC)
Principal Investigator : Prof Dr. Wan Ahmad Tajuddin Wan Abdullah
Department: Physics
Faculty: Science
Summary of Research Proposal
The Quantum Chromodynamics (QCD) is well understood theoretically
and experimentally in hard processes (involving high momenta), there
lacks undertanding for soft processes, where perturbative desciptions are
not reliable. One manifestion of QCD are particle jets produced in high
energy collisions, where intrajet dynamics would especially reflect the soft
processes involved. Studying this dynamics would yield understanding of
soft QCD and thus would strengthen the whole understanding of QCD itself.
Of interest are the question of the production of baryon and multiquark
states, and the effect of heavy quarks.
Objectives
Methodology
Outcome
The objectives are to develop
substructure and exclusive
analysis techniques for jets, so
as to enhance understanding of
jet content, to study production
of baryons and other multiquark
states in jets, to study heavy
hadron production in jets and to
study jet differences from different
partons.
The Large Hadron Collider (LHC)
at CERN, Geneva, Switzerland
is currently the highest energy
hadron collider on earth, colliding
protons at energies of 7 TeV. The
CMS collaboration handles the
CMS detector. Different kinds of
analyses have been carried out,
including famously the search
for the Higgs boson, as well as
for other new phenomenolgy
like supersymmetry and extra
dimensions. Studies of jet physics
would involve the analysis of data
of collison events containing jets.
For the respective objectives
given above, the approach to be
taken can be:
1.
Measurement of Inelastic J/
psi and psi’ Photoproduction
at HERA DESY-12-226
(November 2012) to be
published in JHEP
2.
Combination and QCD
Analysis of Charm
Production Cross Section
Measurements in DeepInelastic ep Scattering
at HERA DESY-12-172
(November 2012) to be
published in Eur. Phys. J. C
3.
Production of Z^0 bosons in
elastic and quasi-elastic ep
collisions at HERA DESY12-168 (October 2012)
published in Phys. Lett. B
718 (2013) 915-921
1.
For substructure, look
recursively for subjets
and subsubjets etc., by
boosting to the jet rest
frame. It would also be
interesting to reconstruct jets
exclusively bottom-up using
decay channel information,
particle identification, and
probabilistic analysis.
2.
Baryons and other multiquark
states can be identified by
reconstructing their decays.
3.
Heavy quark content can
be identified through their
decay channels and deca
reconstruction.
4.
Origin of jets can be
identified e.g. through
tagging via ‘other’ particles
(e.g. thorugh leptonic decays,
long lifetimes, etc). Topology,
etc of jets of different origins
can be compared.
Possible High Impact Journals
for Publications
1.
Physics Letter B
2.
Journal of High Energy
Physics
3.
Journal of Physics GNuclear and Particle Physic
Collaborators
CMS Collaboration (1740
scientists from 179 institutions
from 41 countries) & ZEUS
High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/150
Title: The Development of Islamic Project Management
Framework (IPMF) of Construction and Development
Industry
Principal Investigator: Prof. Dr. Hamzah Abdul Rahman
Department: Department of Quantity Surveying
Summary of Research Proposal:
A wide range of standards methodologies, guide and frameworks is currently
available for project management (e.g. ISO, ANSI. Due to this diversity,
the selection and application of PM approaches is a complex problem
for organizations. The challenge is to identify an approach that is widely
used among project partners and stakeholders so that a consensus can
be established, is applicable for this type of organization and the type of
projects so that it can be implemented efficiently and unfolds real benefits
for the organization so that it is effective. Up to now, little research has been
carried out into the Islamic perspectives and values of project management.
Due to Malaysian culture, the role of Islamic values in business and to meet
the local need in this study a framework for Islamic Project management
of construction and development industry will be developed to be a basis
for construction and development industry in order to fulfill the need and
knowledge gap in this area and to have a project management approach
roots in Islamic values.
Objectives
Methodology
To develop an improved model
from the conventional project
management approaches which
is currently being applied in
construction industry and to
develop a practical framework
for project management in
construction and development
industry based on the improved
model and Is-lamic values.
Development of practical Islamic
Project Management Framework
(IPMF) of Construction and
Development Industry will be
developed to be a basis for
construction and development
industry in order to fulfill the
need and knowledge gap in
this area and to have a project
management approach roots in
Islamic values.A comprehensive
and exploratory study will be
conducted through current
Project Management approaches
to identify current problem and
deficiencies associated with them
and to Identify the major problem
in construction industry. After the
gap has been identified a new
framework comprises of Islamic
Values to supplement existing
framework will be developed based
on most reliable islamic resources(
Al-Quran) and islamic Scholars.
Outcome
Development of practical Islamic
Project Management Framework
(IPMF) of Construction and
Development Industry to be a basis
for construction and development
industry in order to fulfill the need
and knowledge gap in this area
and to have a project management
approach roots in Islamic values.
Possible High Impact Journals
for Publications
1.
Journal of civil engineering
and management
2.
Building research and
information
3.
Automation in construction
4.
International journal of
project management
5.
journal of construction
engineering and
management-asce
Collaborators
Dr. Zulkifli Hj. Mohd Yusoff,
Academy of Islam, Universiti
Malaya
Dr. Wang Chen, Department of
Quantity Surveying, Faculty of
Built Environment, Uni-versiti
Malaya,
Dr. Abdul Aziz Abdullah, Faculty
Of Business Management and
Accountancy, University Of Sultan
Zainal Abidin
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/151
Title: 14-Membered Macrocyclic Systems
Dibenzotetraaza[14]annulenes as Ligands for Metal Ions
and Hosts for Fullerenes
Principal Investigator: Prof Hapipah Mohd Ali
Department: Chemistry
Faculty: Faculty of Science
Summary of Research Proposal
Dibenzotetraaza[14]annulenes are a class of synthetic macrocyclic
compounds which have at-tracted a great deal of continued interest
because of their resemblance to the naturally occurring porphyrins, thus
their relevance in bioinorganic chemistry. Moreover, due to the extended π
system of dibenzotetraaza[14]annulenes, they have been studied for their
ability to cocrystallize with fullerenes. In this study we introduce a new class
of dibenzotetraaza[14]annulenes, having indolenine moieties, as ligands
for transition metal ions. The cocrystallization behavior of the synthesized
macrocycles with fullerenes will be studied. Use of 2-(diformylmethylidene)3,3-dimethylindole inserts two conjugated arms on the macrocycles, thus
promotes the cocrystalli-zation with fullerenes.
Objectives
Methodology
Outcome
Preparation of new
Dibenzotetraaza[14]annulenes
(indolenine-base), study
the coordination behavior
of the indolenine-based
dibenzotetraaza[14]annulenes
towards transition metal ions and
to study their cocrystallization
behavior with Fullerenes
Dibenzotetraaza[14]annulenes
will be prepared by the 2:2
condensation of substituated
o-phenylene diamines with
2-(diformylmethylene)-3,3dimethylindole. The metal
complexation will be done by
reacting the macrocycles with the
metal salt in the presence of a
tertiary amine base. The metal in
principle can be coordinated by
the central nitrogen atoms or the
indolenine nitrogen atoms.
Introducing a novel macrocyclic
system for metal coordination
chemistry and host-guest
cocrys-tallization studies. The
products are expected to be
good candidates for sensors
(light humidity and temperature
sensors).
The cocrystallization of the
macrocycles with fullerene will be
carried out in CS2, Benzylchloride, Chlorobenzene and CHCl3.
Crystal structures will be analyzed
by X-ray crystallography.
Diffraction data will be measured
using a Bruker APEX II CCD
area-detector diffractometer.
The orientation matrix, unit cell
refinement and data reduction
will be all handled by the APEX
II software (SAINT integration,
SADABS absorption correction).
Possible High Impact Journals
for Publications
1.
Inorganic Chemistry (Q1,
Impact Factor: 4.601)
2.
Dalton Transactions (Q1,
Impact Factor: 3.838)
Collaborators
Professor Marilyn M. Olstead,
University of California, Davis,
USA
High Impact Research Annual Report 2012
RESEARCH PROPOSAL
(HIR-MoHE 4 Years)
Faculty of Medicine
Project No: UM.C/HIR/MOHE/MED/18
Title: Identification and Genotyping of Medically
Important Parasites and Mosquitoes
Sub-Project 1: Identification, Cloning, Expression, and Characterization of the Gene for Plasmodium falciparum and Plasmodium vivax Surface Proteins in Isolates from Low and High Malaria Transmission Areas
Sub-Project 2: Genotypic Characteristics of Toxoplasma gondii Strains from Human and Feline animals
Sub-Project 3: Molecular Characterization of Opportunistic Pathogens
Sub-Project 4: Identification and Genotyping of Medically Mosquitoes
Principal Investigator: Dr. Lau Yee Ling
Sub-Project 1: Professor Madya Dr. Hesham Mahyoub Sarhan Al-Mekhlafi
Sub-Project 2: Professor Madya Dr. Veeranoot Nissapatorn
Sub-Project 3: Professor Dr Rohela Mahmud
Sub-Project 4: Dr Lau Yee Ling
Department: Parasitology
S-P 1
S-P 2
S-P 3
S-P 4
Summary of Research Proposal
Sub-Project 1: Malaria is the most important vector-borne parasitic disease in
the world in terms of morbidity and mortality. Our study is aimed to identify and
clone the Plasmodium surface proteins, to ex-press, purify and characterize
recombinant TRAMP using phage display library and to investi-gate the
naturally acquired cellular immunity to PlasmodiumTRAMP for future trials of
TRAP-based vaccines in patients from low and high malaria transmission areas.
Sub-Project 2: Toxoplasmosis is a zoonotic disease caused by Toxoplasma
gondii, infecting warm blood ani-mals included man. Different clonal lineages
of T. gondii result in very different outcomes. It is important to determine the
lineage types of T. gondii associated with human toxoplasmosis. This project
aims to determine the association between Toxoplasma seropositivity
and typing strains in these patients and thus develop a Loop-mediated
isothermal amplification (LAMP) test for toxoplasmosis in these patients.
Sub-Project 3: Opportunistic parasitic infections caused by
Cryptosporidium, microsporidia, Entamoeba and Acanthamoeba are
important causes of morbidity and mortality especially in immunocompromised individuals. In the present study, we will genetically characterize
Cryptosporidium, micro-sporidia, Entamoeba and Acanthamoeba from a
diverse cohorts of immunocompromised pa-tients in Malaysia.
Sub-Project 4: With the changes in ecological environment and with the loss
of biodiversity, the distribution of vector mosquitoes have also changed.
Control strategies have also led to the eradication of some vectors and their
habitat may now be occupied by other species. Thus it is important to study
the distribution of these vectors.
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High Impact Research Annual Report 2012
Objectives
Identification and characterization
of pathogenic parasites and
medically important mosquitoes in
Malaysia
Methodology
Sub-Project 1: Blood samples
will be collected through active
case detection and passive case
detection sur-veys. Moreover,
archive positive slides will be
collected form malaria control
units and health centers. PCR
amplification, cloning and protein
expression will be done for the
positive samples. Anti-PfSPATR
and PvSPATR antibodies will
be generated. An indirect
immunofluorescence assay will be
used to detect the expression of
PfSPATR and PvSPATR protein in
sporozoite and erythrocytic stages
of P. falciparum and P. vivax
parasite.
Sub-Project 2: Toxoplasmosis
will be screened for the collected
blood samples for specific IgM
and IgG anti-bodies. Molecular
study on genotyping strains
of Toxoplasma gondii will be
carried out and LAMP test will be
developed.
Sub-Project 3: Faecal and
tissue samples will be taken
from immunocompromised
patients and will be screen
using conventional method for
intestinal opportunistic parasites
such as Entamoeba, Cryptosporidium and microsporidia while
Acanthamoeba will be isolated
from tissue samples after a
cultivation process. Once isolated,
genomic DNA will be extracted
from the positive samples and the
parasites’ genetic composition will
be analysed using real-time PCR
targeting multi locus. Amplicons
obtained will be sequenced and
subsequently analysed using
computational software.
Sub-Project 4: The mosquitoes
species chosen for this study
will be the vectors of dengue
and filarial. Chosen mosquitoes
species in different ecological
settings in Peninsular Malaysia,
Sabah and Sarawak will be
sampled. The mitochondrial
cytochrome oxidase c subunit
I (COI) and nuclear ribosomal
internal transcribed spacer 2
(ITS2) of the chosen species will
be sequenced and analysed.
Outcome
Sub-Project 1: Findings on
important surface proteins of
P. falciparum and P. vivax as
the potential malaria vaccine
candidates
Sub-Project 2: New therapeutic
agents relating to Toxoplasma
strains susceptibility in treating
human toxo-plasmosis
Sub-Project 3: Genetic
characterisation of Malaysian
isolates of opportunistic parasites
Sub-Project 4: This study will
provide the first CO1 barcode for
Malaysian mosquitoes
Possible High Impact Journals
for Publications
1.
Malarial Journal
2.
PLoS One
3.
Journal of Clinical
Microbiology
4.
American Journal of Tropical
Medicine and Hygiene
5.
Emerging Infectious Diseases
Collaborators
Dr. Laurent Renia, Laboratory of
Malaria, Singapore Immunology
Network, A*Star
Dr. Bruce Russell, Laboratory of
Malaria, Singapore Immunology
Network, A*Star
Project No: UM.C/625/1/HIR/MOHE/MED/19 - Sub Project 1
Title: Inter-racial comparison of risk factors in
ROP Progression in a multi-racial South East Asian
community and Identifying the predictive values of
growth factors in the development of retinopathy of
prematurity (ROP).
Principal Investigator: Dr Tengku Ain Kamalden
Department: Ophthalmology
Summary of Research Proposal
Retinopathy of prematurity or ROP is a visually disabling and sightthreatening disease affecting babies born prematurely. Recent advances in
neonatal care have resulted in the survival of very low birth weight babies,
from as low as 500gm, which is comparable to developed countries. With
low birth weights being a major risk factor for developing retinopathy, the
High Impact Research Annual Report 2012
rate of ROP is sharply increasing. This disease is treatable with a potentially
good visual outcome if diagnosed and treated early. Identification of
predictive markers is therefore imperative in distinguishing cases that would
require early and aggressive treatment.
Objectives
Methodology
Outcome
1.
Blood samples (minimum of
0.7ml) from mothers and babies
born with a birth weight of less
than 1500gm will be collected
and subjected to protein analysis
using Western blotting techniques
and protein assays, and genetic
analysis using Gene sequencing,
quantitative and qualitative
polymerase chain reaction.
Other relevant information such
as demographic data, ante-,
pre- and postnatal conditions, as
well as maternal co-morbidities
will be analysed as risk factors.
Comparisons will be made among
babies from different race groups,
as well as with babies born
weighing more than 1500gm.
The laboratory findings will be
correlated to clinical findings
during routine fundus examination
and recorded on retinal camera.
Babies will be followed-up to
assess for the progression of
disease.
Better understanding of the
risk factors of retinopathy of
prematurity, and determining the
2.
To compare the risk factors
and genetic predisposition
for the development and
progression of retinopathy of
prematurity among the major
ethnic groups in a South
Asian community.
To identify the role of
selected growth factors
in premature babies in
predicting the development
of retinopathy of prematurity
with a potential for screening
purposes.
genetic susceptibility among the
different ethnic groups.
Possible High Impact Journals
for Publications
Ophthalmology, Graeves Archives
of Ophthalmology, Investigative
Journal of Visual Sciences, British
Jounral of Ophthalmology
Collaborators
John Radcliffe Hospital/University
of Oxford (CK Patel), Johns
Hopkins School of Medicine,
USA (Samarjit Das), Cyberjaya
Medical School (Solihin Salleh),
Paediatric Department, UMMC
(CT Lim), Universiti Sains Malaysia
(Rozieyati Md Salleh)
Project No: UM.C/JIR/MOHE/MED/19 – Sub Project 2
Title: Central and peripheral corneal thickness
changes in the normal pregnancy and menstrual
cycle and correlation of serum levels of estrogen and
progesterone with corneal thickness the relationship
of DHEA’s,oestrogen and testerone evels with ARMD:
Evaluation of changes after corneal cross linkage
Principal Investigator: Professor Dr Visvaraja Subrayan.
Faculty: Medicine
Brief Summary of Research Progress
We have collected 201 patients for the ARMD study and another 98 patients
for the normal pregnancy study. For the cross linkage study we are awaiting
for the crosslinkage and Ocular response analyser. The tendering process
has gone through and the machines are supposed to be delivered in January
2013. Dr Dona Sonali has been employed as a research assistant. Her main
function is to collect patients and keep record of the data.
From the patient in our system we have done a brief study and published a
paper in CORNEA which is a tier 2 journal.
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High Impact Research Annual Report 2012
Outcome
Collaborators
1.
Central Corneal Thickness
Measurements With Different
Imaging Devices and Ultrasound Pachymetry.
Local:
Associate Professor Dr Sushil
Vasudevan, UiTM
2.
Tai LY, Khaw KW, Ng CM,
Subrayan V. Cornea. 2012
Oct 23. [Epub ahead of print]
International:
Van C. Lansingh MD, PhD
Regional IAPB/VISION 2020 Latin
America Coordinator
Voluntary Assistant Professor of
Ophthalmology
Miller School of Medicine,
University of Miami
Professor Dr Baljean Dhillon
University of Edinburgh
Project No: UM.C/HIR/MOHE/MED/19 – Sub project 3
Title: Serum Levels of Vascular Endothelial Growth
Factor, Homocysteine and Interleukin-6 in Correlation
with Retinal Vessels Caliber in Patients with Diabetic
Retinopathy
Principal Investigator: A/Prof Tajunisah Begam Binti Mohamed Iqbal
Department: Ophthalmology
Summary of Research Proposal:
It has been shown that increased serum levels of VEGF may act as a key
regulator of Diabetic Retinopathy (DR) and provide a potential tool for risk
assessment in diabetic patients. The involvement of VEGF in pathogenesis
of diabetic retinopathy is well established, but there is lack of data regarding
correlation of this value with retinal vessels diameter. Furthermore, retinal
vascular calibre measurement using adaptive optics is highly sensitive
method of visualization and monitoring of early signs of diabetic retinopathy.
This correlation may clarify the role of non-invasive method of image
processing to predict the progress or find the severity of retinopathy.
Objectives:
Methodology:
Outcome
To correlate serum levels of
Vascular Endothelial Growth
Factor, Homocysteine,
Interleukin-6 and renal function
with Retinal Vessels Caliber in
Patients with Diabetic Retinopathy
Samples: 70 patients include 35
patients with DR as case and 35
patients as controls.
Better understanding of serum
cytokines effect on pathogenesis
of diabetic retinopathy and to find
a molecular link between diabetic
retinopathy and nephropathy
and correlation with cytokines
levels, also to find the role of
the retinal microcirculation and
retinal vessels diameter in diabetic
nephropathy.
Levels of VEGF and IL-6 will be
determined by ELISA method
using specific kits. Homocystein
levels will be measured using
Immunoturbidimetry assay.
Furthermore,we are measuring
themicroalbuminuria, renal and
lipid profile, HbA1c and fasting
blood sugar.
Fundus photographs of
acceptable quality will take and
retinal vascular caliber will be
measured using a computerbased program (IVAN, University
of Wisconsin).
High Impact Research Annual Report 2012
Possible High Impact Journals
for Publications:
1.
Ophthalmology,
2.
IOVS,
3.
Microcirculation,
4.
Diabetes,
5.
Archives of Ophthalmology
Collaborators
University of Wisconsin –
Madison School of Engineering
and the Fundus Photograph
Reading Center, Department
of Ophthalmology and Visual
Sciences, University of Wisconsin
– Madison
Project No: UM.C/HIR/MOHE/MED/19 – Sub project 4
Title: Animal model for determining dose of intravitreal
antibiotics that can cause retinal toxicity
Principal Investigator: Associate Professor Kenneth Fong Choong Sian
Department: Ophthalmology, Faculty of Medicine, UM
Summary of Research Proposal
Endophthalmitis is a devastating complication of ocular surgery and
intravitreal antibiotics are the mainstay of treatment. The optimal dose is
unknown and current doses used may actually be toxic to the retina which
impairs visual recovery. Using a mouse eye model, we will inject various
doses of newer intravitreal antibiotics into the mouse eye and look for signs
of retinal toxicity with electron microscopy and ganglion cell analysis. We
have already developed such an experimental model in collaboration with
Prof Murali in the Dept of Anatomy, University of Malaya.
Objectives
Methodology
Outcome
To determine (1) whether
intravitreal moxifloxacin and
besifloxacin causes retinal toxicity
(2) at which concentrations do
these anbiotics cause retinal
damage, and (3) at which level
of the retina is the damage most
prominent.
Animal rat models will be given
increasing doses of intravitreal
moxifloxacin and besifloxacin.
Subsequently the function of
the retina shall be measured
using electroretinography (ERG).
The anatomical damage shall
be analysed using Retrograde
Labelling and Quantification of
Retinal Ganglion Cells (RGC)
where a dye will be injected
into the brain to label the retinal
ganglion cells which are visualized
on a flatmounted retina using
fluorescence microscope. Cross
sections of the retina shall be
analyzed for retinal thickness as
well as for immunohistostaining
to determine the extend of retinal
damage on the different layers of
the retina.
Better understanding of the effect
of intravitreal antibiotics on the
retinal function and anatomy. This
can be used as a safe guide to
use of intravitreal antibiotics in
endophthalmitis.
Possible High Impact Journals
for Publications
Eye, Ophthalmology, British
Journal of Opthalmology
Collaborators
Anatomy Department, UM (Prof
Murali), University of ITM (UiTM)
(Dr Nurasyikin Mustapha
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/MED/20
Title: Endothelial dysfunction in dengue haemorrhagic
fever
Principal Investigator: Prof. Dr. Shamala Devi Sekaran
Department: Department of Medical Microbiology- Faculty of Medicine
Summary of Research Proposal
Dengue hemorrhagic fever (DHF) is characterized by fever, bleeding, and
pleural effusion which may be caused by increased vascular permeability.
The endothelium is a crucial homeostatic organ essential for normal body
functioning, responding to various stimuli and maintaining nor-mal blood
flow. Various mediators are released, signals conducted and response
effected. Hence dysfunction many result in imbalances between vasodilating
and vasoconstricting states. Hence it is assumed that endothelial
dysfunction plays a role in the pathogenesis of DHF. The current project
proposes to investigate the numerous functions of the endothelium at the
molec-ular level systematically.
Objectives
Methodology
To investigate endothelial
dysfunction in dengue
haemorrhagic fever which lead to
vascular leakage at the molecular
level.
Basically, patient recruitment
and sampling will be carried
out standard procedures.
Various endothelial cell lines
will be stimulated under various
conditions and mediators
(measured by ELISAs kits,
Flow Cytometry, Fluorescence
microscopy and Western
blots. Endothelial function and
Endothelial cell markers assessed
in vitro and the signaling pathways
determined by western blots.
Animal models will be utilized for
assessment in vivo and validity
and efficacy of drugs developed
assessed in vitro and in vivo.
Outcome
Better understanding and
knowledge into the risk factors
associated with vascular leakage
Possible High Impact Journals
for Publications
1.
PLOS journals, Lancet
Infectious Diseases
2.
Clinical Infectious Diseases
3.
PNAS
4.
PLOS Medicine
Collaborators
PUGSOM (Asif Khan, Steve
Dumler),
John Hopkins USA (Dennis Grab,
JT August),
University of South Florida (Azizan
Azliyati),
UiTM (Wang SM), UMMC (Rishya
Manikam, Sasheela, Santha
Kumari),
UM (Ong KC, Zandi K, Malhoot,
A Rathakrishnan, Yeo SL, P
Rajendran, Tang YQ, Lee SH, Le
CF), Biovalence (Huan UE)
High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/MED/22
Title: Mechanisms of cardiovascular therapeutic
potentials of boldine and nitrite in animal models of
diabetes mellitus and hypertension
Principal Investigator: Prof Dr. Mohd Rais Mustafa
Department :Centre of Natural Products and Drug Discovery, Deparment
of Pharmacology
Summary of Research Proposal
Hypertension and diabetes mellitus affects health of millions of people
worldwide and are major risk factors for cardiovascular disease (CVD), the
number one killer globally. Cardiovascular complications are characterized
by endothelial dysfunction. There are increased evidences demonstrating
excessive oxidative stresses associated with the increased production of
super-oxide may account for the endothelial dysfunction in the early stage
of these diseases. It is worth noting that the use of antioxidant has been
implicated for the past few decades for its therapeutic potential to combat
the adverse effect raised by oxidative stress. The present research sought
to explore and study the therapeutic potential of an boldine and nitrite as
antioxidants in preventing such cardiovascular complications.
Objectives
Methodology
The present research aims to
investigate the role of ROS on
endothelium-dependent and
-independent relaxation in the
isolated mouse/rat aorta from
diabetic and hypertensive animal
models. The exact cause for
the ROS generation and the
correlation with the use of boldine
in the vascular wall of diabetic
and hypertensive mouse/rat
aortas remains unclear. Therefore,
this study also investigates the
underlying molecular mechanism
and signal transduction pathway
involved in the development of
endothelial dysfunction induced
by oxidative stress and the
po-tential novel target by which
boldine/ nitrite may mediate their
beneficial effects on endothelial
function.
The diabetic and hypertensive
rats /mice acutely treated with
nitrite and chronically treated
with boldine and the aortas will
be obtained by the end of each
treatment to assess the time- and
dose-dependent improvement in
acetylcholine-induced relaxations.
The vascular benefit of boldine will
also be correlated with alterations
in several aspects including:
intracellular ROS level and
oxidative stress markers.
Outcome
The novel finding will be provided
a new sight on the mechanism for
therapeutic potential of boldine/
nitrite in preventing cardiovascular
complications in hypertension and
diabetes mellitus.
Possible High Impact Journals
for Publications
Biochemical Pharmacology,
British Journal of Pharmacology,
Cardiovascular Research
Collaborators
Dr. Dharmani Devi Murugan
(University of Malaya); Prof Huang
Yu and Dr Tian Xiao Yu ( Chi-nese
University of Hong Kong) and
Dr. Ajay Machha ( oregan State
University, USA).
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RESEARCH PROPOSAL
(HIR-MoHE 5 Years)
Faculty of Engineering
Project No: UM.C/625/1/HIR/MOHE/ENG/24
Title: Applications of Solar Energy In Agricultural
Sector
Principal Investigator: Prof. Dr. Saad Mekhilef
Department: Dept. of Electrical Engineering, Faculty ofEngineering
Summary of Research Proposal
Solar energy can be used in agriculture in a number of ways, saving money,
increasing self-reliance, and reducing pollution. Solar energy can cut a
farm’s electricity and heating bills. Solar heat collectors can be used to
dry crops and warm homes, livestock buildings, and greenhouses. Solar
water heaters can provide hot water for diary operations, pen cleaning, and
homes. Photovoltaic (solar electric panels) can power farm operations and
remote water pumps, lights, and electric fences. Building and barns can be
renovated to capture natural day light, instead of using electric light, solar
power is often less expensive than extensive power lines, making the farm
more economical and efficient.
Objectives
General Objectives:
1.
2.
3.
4.
5.
To extract energy from
natural re-source such as the
sun, wind, water.
To utilize the extracted
energy in a usable form for
agricultural application such
as heating, lighting etc.
To develop mew algorithm
and tech-nologies for future
expansion in agri-cultural
sector.
To design electrical
instruments and equipments
for increasing productivity in
agriculture.
To provide link between area
1 and area 2.
Technical Objectives:
6.
7.
8.
To investigate multilevel
inverter to-pology for fast
and reliable control methods.
To improve existing
Maximum Power Point
Tracker (MPPT) protocol to
achieve maximum output.
To design switching scheme
for multi-level dc-dc
converter for voltage conversion.
9.
To implement energy storage
and dis-tribution system from
wind turbine and PV cell.
10. To incorporate power and
chemical engineering for
interlinking agricultural
electrochemical systems.
3.
Energy storage and
distribution system using
efficient PV cell
4.
Energy saving by
implementing DC-DC
converter with LED systems
Possible High Impact Journals
for Publications
Methodology
1.
Phase 1: Data collection and field
work
IEEE transaction on industrial
electronics
2.
Renewable and sustainable
energy review
3.
Journal of power electronics
4.
IEEE transaction on power
electronics
5.
IET transaction on power
electronics
6.
Energy
7.
Applied energy
8.
Solar energy
Phase 2: Chemical equipment
preparation
Phase 3: Design of electrical
equipments
Phase 4: Interconnection between
energy source and agricultural
application
Phase 5: Campaign, awareness,
seminars and publication
Outcome
1.
New algorithm and control
strategy for multilevel inverter
2.
Efficient energy transfer
protocol using MPPT
(maximum power point
tracker)
Collaborators
Prof. Mutsuo Nakaoka, Dept.
of Electrical and Computer
Engineering, Yamaguchi University, Japan.
Prof. Hong-Tzer Yang, National
Cheng Kung University, Taiwan
High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/ENG/25
Title: Development of an advanced model and optimal
control system for gas-phase olefin polymerization in
Fluidized-Bed Catalytic Reactor
Principal Investigator: Prof. Ir. Dr. Mohd Azlan Hussain
Department: Department of Chemical Engineering
Summary of Research Proposal:
Modeling and control of polymerization process in fluidized bed reactors
as one of the most widely used processes for polyolefin production are
challenging issues facing industries. This is mainly because of the high
non-linearity of the process dynamics due to the complicated reac-tion
mechanisms, complex flow characteristics of gas and solids. In this study, a
detailed and easily to understand CFD model will be developed for industrial
fluidized bed catalytic olefin reactor. Outcome of this study will bring a
significant solution to overcome the challenge for scaling up the reactor
design through advanced CFD approach. On the other hand, due to process dynamic nonlinearities and difficulties involved in the control of the gas
phase olefin polymerization fluidized bed reactor, an efficient process control
scheme need to be implement-ed. An optimal and integrated real time
control system will also be proposed from this research work.
Objectives
Methodology
To develop an improved model
from the first principle of CFD
approach in order to simulate
polymerization in batch reaction in
fluidized bed catalytic reactor for
olefin production.
Development of an advanced
simulation model which will
be developed to describe the
mecha-nism of olefin coordination
polymerization to get a detailed
picture of the molecular structure
for homopolymer and copolymer
made with coordination reaction
mechanisms. A comprehensive
study will be conducted through
CFD approaches with support
of available computational
re-sources. Non-linear process
model based control will be
studied for optimal control of
fluidized bed catalytic reactor
under various conditions. Final
validation study will be conduct
to suggest the advanced control
system.
To develop a practical tool to
predict polymer production
rate and product quality on an
industrial scale.To develop an
advanced control system for a
gas phase olefin reactor using real
time advanced control system
Outcome
Development of advanced model
and optimal control system
for industries can be used to
in-crease the yield of Olefin
production in Petrochemical
Plants at Kertih, Malaysia which
will be a cost effective and
practical process tool for real
plants.
Possible High Impact Journals
for Publications
1.
Industrial & Engineering
Chemistry Research
2.
Chemical Engineering
Journal
3.
Progress in Polymer Science
4.
Powder Technology
Collaborators
1.
Prof. I.M.MUJTABA; School
of Engineering, Design &
Technology University of
Bradford. Bradford BD7 1DP,
UK
2.
Dr. Nayef Mohamed Ghasem,
Department of Chemical and
Petrolium Engineering, UAE
university, Al Ain, United Arab
Emirates.
3.
Prof Zheng-Hong Luo;
Shanghai Jiao Tong
University, Shanghai, China
4.
Prof. Dr. Navid Mostoufi;
Department of Chemical
Engineering University of
Tehran, Iran.
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/ENG/26
Title: Nano-mechanical Properties of Advanced Lead
Free Solder for Microelectronics Packaging.
Principal Investigator: Prof. Dr. A.S.M.A. Haseeb
Department: Department of Mechanical Engineering
Summary of Research Proposal
Recent environmental concerns are forcing semiconductor industry to come
up with lead free, green electronic products that can ensure reliability. Apart
from the drive to go lead free, semi-conductor industry is also experiencing
a trend towards miniaturization. Interconnects with small dimensions have
interfacial intermettalic compound (IMC) that constitutes a larger fraction
of the solder volume. Therefore IMC properties are becoming ever more
important as miniaturization continues. To understand and predict the
performance of small solder interconnects, it is highly important to measure
and understand the properties of materials at small dimensions (submi-cron/
nanometer). In this project, evaluation of nanomechanical properties of
ultra-small inter-connects will be done by nanoindentation technique which
can measure mechanical properties of materials with dimensions down to a
few tens of nanometers.
Objectives
Methodology
1.
Preparation of solder Sn-base
solder will be carried out with and
without alloy additions using:
2.
To study the properties of
different phases in lead free
solder.
To investigate the effect
of alloy additions on the
hardness and modulus of
interfacial IMC.
3.
To examine the influence of
processing and treatment
conditions on mechanical
properties.
4.
To study the nanoindentation
creep of various phases in
lead free solders.
1.
conventional metallurgical
alloying,
2.
nanoparticle addition
method, and
3.
solid state diffusion of
nanolayers. In-depth
structural and chemical
characterization of the
solders will be done by using
microscopic, diffraction and
spectroscopic techniques.
Mechanical properties of
the prepared solders will be
studied by nanoindentor.
Outcome
New Knowledge about the nanomechanical properties small
solder interconnects.
Possible High Impact Journals
for Publications
1.
Materials Science and
Engineering A
2.
Intermetallics
3.
Journal of Alloys and
Compounds
4.
Advanced Materials
5.
Nano Letters
Collaborators:
Prof. Samjid Mannan, King’s
London College, United Kingdom.
High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/ENG/27
Title: Bovine Hydroxyapatite Derived Porous Bone Graft
for Biomedical Application
Principal Investigator: Prof. Dr. Mohd Hamdi Abd Shukor
Department: Faculty of Engineering
Summary of Research Proposal
Demand for development of biomaterial study arises due to improvement of
average human lifespan, as well as higher expectation of the quality of life.
The success of biomaterial application critically depends on the achievement
of a stable attachment to connective tissue. In producing a feasible
biomaterial which will survive in the body for a long period of time, the
identified material needs to be developed specifically for clinical application.
Hydroxyapatite (HA), a calcium phosphate ceramic, is chemically similar
to the mineral component of bones and hard tissues in mammals. It is one
of few materials that are classed as bioactive, meaning that it will support
bone ingrowth and osseointegration when used in orthopaedic, dental
and maxillofacial applications. Various techniques have been developed
to produce hydroxyapatite such as sol-gel method, hydrothermal method,
electrophoretic deposition, continuous precipitation and solid-state reaction.
There has been a constant quest to scale up the process to bulk processing,
thus many research have tried to obtain HA from abundant natural sources.
Objectives
Methodology
Outcome
1.
This project will strengthen
the fundamental knowledge
required in the field of
biomaterial technology, bovine
hydroxyapatite and to explore
new method to produce porous
bone graft. Parallel sub-projects
will encompass a wide range
of research scope within the
research field including laboratory
experimental work (Preparation
of Bovine hydroxyapatite Fine
Powder Via Calcinations Method,
Development of Porous bone
graft and Development of
reinforced Bovine Hydroxyapatite
Porous structure) and material
characterizations. The major
focus of the research is on the
fabrication and development of
porous bone graft for biomedical
applications.
No. of Tier 1 Publications
Expected : 27
To determine the parameters
that influence bovine
hydroxyapatite fine powder
preparation.
2.
To develop and evaluate the
performance of porous bone
graft suitable for biomedical
application.
3.
To characterize the physical,
chemical and mechanical
properties of porous bone
graft.
(a) List of current publications :
1.
Ceramics international
(Impact Factor: 1.751,
Tier 1)
Possible High Impact Journals
for Publications
1.
Biomaterials (Impact Factor:
6.646, Tier 1)
2.
Journal of Materials
Chemistry (Impact
Factor:4.646, Tier 1)
3.
Int. Journal of Engineering
Science (Impact Factor:
1.366, Tier 1)
4.
Materials Science and
Engineering: A (Impact
Factor: 1.806, Tier 1)
5.
Materials
Characterization(Impact
Factor: 1.225, Tier 1)
Collaborators
Professor Ari Ide-Ektessabi, Kyoto
University
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/ENG/28
Title: Reconstruction of Artificial Prosthesis Limbs
Principal Investigator: Professor Dr. Imtiaz Ahmed Choudhury
Department: Engineering Design and Manufacture
Summary of Research Proposal
Every year millions of people throughout the world become impaired
suffering of osteoarthritis, stroke, poliomyelitis and hemiplegia. About one
half of stroke survivors live with impairments such as muscle weakness,
abnormal muscle tone and sensory impairments of lower limb mus-cles.
Clinical lower limb orthotics increase mobility for a wide range of individuals.
By using or-thosis about 52 to 85% of hemiplegic patients regain the
capacity to walk. In this case, a stance control knee–ankle–foot orthosis
(KAFO) may be appropriate. This type of orthosis is composed of several
segments which act on both the knee and the ankle joint.
Objectives
Methodology
Outcome
1.
We aim to reduce muscle
activation without changing
the kinematics. Preservation
of kinematics served as a
starting point in the required
characteristics of our project,
among which are: device weight,
comfort, and simplicity. Comfort,
simplicity, and manufacturability
are the prime criteria for our
design. A simple design with
good control system reduces
device weight by implementing
fewer components and makes
the device easier to manufacture.
Later on completing the
experimental design we will also
prepare a CAD design of the
prototype before going for final
drawing. After completing the
design and CAD works we will
go for the final prototype making
and modeling. Later on we have
to collect some data and analyze
the results using the knee orthosis
in motion analysis lab. The data
collection would on: joint and
orthosis kinematics anal-ysis,
torque and torsion analysis,
knee moments with respect to
joint angle and stiffness, muscle
activation level, adaption rate etc.
1.
To improve the quality of life
of various impaired patients
in Malaysia
2.
To develop the local
technology (in the field of
design and fabrication) of
lower limb orthotics
3.
Development of local
expertise
4.
Manufacture such kind of
lower limb orthotics locally
2.
To design and develop
robotic knee and knee ankle
foot orthosis suitable for
impaired pa-tients assisting
mobility of lower extremity.
To validate the design by
collecting data from real
subjects and analyzing for
improvement, if necessary, in
the design.
3.
To develop a better control
system of the orthosis
4.
To determine the usefulness
for specific applications of
the ortho
Possible High Impact Journals
for Publications
1.
Archives of Physical
Medicine and Rehabilitation
2.
Clinical Biomechanics
3.
Journals of Biomechanics
4.
Journal of Rehabilitation
Research and Development
5.
Medical Engineering and
Physics
Collaborators
Professor Dr. Mustafizur Rahman,
Dept. of Mechanical Engineering,
NUS, Singapore.
Professor Dr. Peter Lee, Dept.
of Mechanical Engineering,
University of Melbourne, Victoria
Professor Dr. Arthur Mak, Dean of
Students Office, The Hong Kong
Polytechnic University
High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/ENG/29
Title: Fabrication and Characterisation of High
Efficiency Green Technology devices (Solar cells and
Thermoelectric Devices)
Principal Investigator: Dr Suhana bt Mohd Said
Department: Department of Electrical Engineering, Summary of Research Proposal
This project is concerned with the fabrication of high efficiency electronic
devices which are considered “green technology”, ie harvest nature’s
available resources into electricity.
The research strategy involves synthesizing novel organic based electronic
materials, and fabricating them into solar cells and thermoelectric devices.
The use of inkjet printing to fabricate thermoelectric devices will be a
pioneering technique in Malaysia. To complement the experimental work,
simulation work on the molecular (Accelrys Materials Studio) and device
level (Silvaco, COMSOL, ANSYS) are also tackled.
The end point of this research is not only concerned with fundamental, high
impact stud-ies on the physics, chemistry and engineering of these green
technology devices, but it is hoped that these discoveries will also translate
into practical devices for energy harvesting.
Objectives
Methodology
1.
Molecular and device simulation
are first carried out to identify
optimal device and material
pa-rameters for solar cells and
thermoelectrics. Synthesis
and fabrication of the device is
then car-ried out, using inkjet
printing and electrospinning.
Characterisation of the devices is
then carried out to determine its
performance.
2.
To synthesise materials for
high efficiency solar cells and
thermoelectric devices using
nanotechnology
To fabricate high efficiency
solar cells and thermoelectric
devices using materials synthesized in (1)
Outcome
1.
Design and synthesis of
novel materials for solar cells
and thermoelectrics
2.
Fabrication of organic solar
cells and thermoelectrics
using inkjet printing.
Possible High Impact Journals
for Publications
1.
Journal of Nanoparticle
Research
2.
Nanotechnology
3.
Energy
4.
Advanced Materials
Collaborators
Professor Takahito Ono, Tohoku
University, Japan.
Associate Professor Munehiro
Kimura, Nagaoka University of
Technology, Japan.
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/ENG/30
Title: A new technique to mitigate CO2, NOx, SO2
emissions simultaneously in a circulating fluidized bed
system
Principal Investigator: Dr. Brahim Si Ali
Department: Chemical Engineering
Summary of Research Proposal
Oxy-fuel combustion technology consists of combusting the fuel in mixture
of oxygen and recycles the flue gas back into the furnace to control the
adiabatic flame temperature and enrich CO2 concentration to levels as high
as 95% by volume. Co-gasification involves a portion of biomass along with
the coal which helps in reduction of NOx and SOx emissions. This unique
process will be performed in newly designed dual fluidized bed reactor.
The function of this design is to trap the bio-oil from one reactor which will
be further purified for further applications and pure & enriched CO2 will be
produced from the second reactor for easy sequestration.
Objectives
Methodology
The design of a dual fluidized
beds reactor system in which one
acts as a gasifier and another as
combustor with loop seal. The
condensable gases will produce
bio-oil for further applications.
The basic characteristic properties
of the coal/biomass (ultimate
and proximate analysis) will
be analyzed prior to do initial
experiments in thermo-gravimetric
analysis (TGA). The most important experiments will be the
findings of the optimum O2
proportions in the oxidant gas and
the desired CO2 proportions in
the product gas. Co-gasification
is a heterogeneous reaction hence
already developed gas-solid
models will be implemented like
random pore model, quantize
solution model etc. Simplified
quasi-global mechanisms and rate
expressions need to be developed
for the volatiles.
The implementation this oxy-fuel
technology for high concentration
of CO2 in the flue gas in dual
fluidized beds reactor. Retrofitting
this technology and new reactor
system to the existing plants will
lower the NOx and SOx emissions
up to zero is achieved by mixing
biomass with coal in dif-ferent
ratios.
Outcome
We plan to retrofit this new
technology to the existing plant.
Further understanding of the
de-signing and modeling of the
dual fluidized bed reactor system
for this new technology. Coal,
biomass and their different blends
for the production of CO2, NOx,
and SO2 in the reactor sys-tem
will be compared.
Possible High Impact Journals
for Publications
1.
Energy
2.
Energy conversion and
management
3.
Fuel processing technology
4.
Fuel
5.
Chemosphere
Collaborators
Prof. Sang Done Kim, .Chemical
& biomolecular engineering dept.
Korea Advanced Institute of
Science and Technlogy, Gusongdong, Yuseong-gu
Dr.Muhammad Irfan, University of
Alberta Edmonton, AB Canada
High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/ENG/31
Title: Sustainable Resource Conservation Approach to
the End of Life of Electrical & Electronic Equipment in
the Context of Energy, Process and Carbon Offsetting: A
Study for Malaysian Industry
Principal Investigator: Assoc. Prof. Dr. Shamsuddin Ahmed
Department: Engineering Design and Manufacture
Summary of Research Proposal
Sustainable manufacturing and product recycling now has to be hand-in
hand. An energy effi-cient durable process with less carbon emission in
environment is now just a demand of time in manufacturing and End of
life (EOL) product treatment. Recycling may be considered as a source
of renewable energy. EOL of products have of multi-degree of complexity
WEEE (waste electrical and electronics equipment), and a new approach
in the field of reuse, recycling, re-manufacturing is to make for conserving
the resources from a sustainable view point in the con-text of Malaysian
Electrical and Electronics industry.
Objectives
Methodology
Using European model,
system dynamic approach and
mathematical programming,
this project aims to develop
a sustainable resources
conservation approach in
manufacturing by investigat-ing
recycling and remanufacturing
potentials for Malaysian EEE
industries. The project will develop an integrated resource
management framework through
the investigation of recycling
po-tential of waste electrical
and electronics devices. It will
characterize recycling, reuse
and re-manufacturing of e-waste
in the contrast of industrial
sustainability via system dynamic
and ex-perimental approaches.
It will also develop mathematical
heuristic and optimization
solution algorithm based on cost,
productivity and flexibility criteria.
There are several steps for
implementation. It will employ
a two-step methodology framework development to
compare system architecture,
context, performance,
sustainability, performance and
regulation with the benchmark
and a comprehensive system
model development by identifying the relevant factors for the
overall system performance.
System dynamic programming,
mathematical modeling etc. will
be done to achieve the objectives.
Outcome
1.
Systematic collection and
recollection of WEEE items.
2.
System dynamic modeling
for long-term sustainable
reuse of WEEE.
3.
Mathematical modeling on
economic, environmental and
technical aspects.
Possible High Impact Journals
for Publications
1.
International Journal
of Product Lifecycle
Management
2.
International Journal of
Sustainable Manufacturing
(IJSM)
3.
International Journal
of Integrated Waste
Management, Science and
Technology
4.
An International Journal of
Manufacturing, Product and
Process Development
5.
International Journal
of Integrated Waste
Management, Science and
Technology
Collaborators
Probable collaborators are:
Malaysian Industrial development
authority (MIDA).
Malaysian Institute of Economic
research, and Department of
Environment Malaysia.
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/ENG/32
Title: Campus Network Smart Grid System for Energy
Security
Principal Investigator: Professor Dr Nasrudin Bin Abd Rahim
Department: UM Power Energy Dedicated Advanced Centre (UMPEDAC)
Summary of Research Proposal
To develop a model and prototype a smart grid campus network system
and to investigate properties of control algorithms, power system reliability
and system protection for grid connect-ed solar PV energy, wind energy
simulator that connects to the campus network grid system. The parallel
operation of the inverter units in grid-connected and islanded mode of
operation will be studied. To provide necessary conditions for the stability
and power quality testing, a distribu-tion system and test loads will be
designed and developed.
Three inverters connected in parallel can provide a realistic testing
environment and represent a power park or remotely connected inverters
(depending on the line impedance between them). To support the
operation of the distributed control method or role of the grid supervisor,
the supervisory control unit will be built. High level monitoring, control and
system debugging will be enabled by using a high performance computer.
Various test loads will be used to obtain the system steady-state and power
quality performance.
Objectives
Methodology
Outcome
To develop a model and prototype
a smart grid campus network
system.
New harmonic sources such
as motor control devices,
interconnection of wind and solar
power converters in distribution
systems will be studied. The
system will be modeled in Matlab
software to investigate various
operation methods of distributed
generation system. The simulation
result will be realized and it will
depend on geographical and
electrical distances between
various generators. A list of test
cases for distributed network will
be made and any problems arising
from the system will be corrected.
New algorithms for control, power
system reliability and system
protection.
To investigate properties of
control algorithms, power system
reliability and system protection
for grid connected solar PV
energy, wind energy simulator that
connects to the campus network
grid system.
Possible High Impact Journals
for Publications
1.
IEEE Transactions on
Industrial Electronics
2.
RENEWABLE &
SUSTAINABLE ENERGY
REVIEWS
3.
ENERGY
4.
APPLIED ENERGY
Collaborators
University of Wollongong,
Australia (Assoc. Professor
Kashem Muttaqi)
High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/ENG/33
Title: Numerical simulations and experimental
investigations on the multiaxial fatigue and cyclic plastic
response of the newly developed aluminum alloy and
FGM for aerospace structures
Principal Investigator: Judha Purbolaksono
Department: Department of Engineering Design and Manufacture
Summary of Research Proposal
Fatigue failure can be visualized as the stress intensities and redistribution
of the loading at the material due to notches, surface roughness or any
material deficiencies. The cyclic plastic deformation and crack initiation are
later occurred. But there is insufficient work on the effects of cyclic plasticity
for fatigue life prediction of materials, especially on the aerospace materials
under proportional and non-proportional loadings. The range of ability of
the cyclic plasticity models including multi-surface and non-linear kinematic
hardening models is studied in detail.
Objectives
Methodology
Outcome
Determine properties and
coefficients of the materials
through uniaxial and multiaxial
fatigue tests. Evaluate the
materials fatigue life considering
interaction of plasticity and fatigue
models. Investigate the effects of
proportional and non-proportional
loadings on the cyclic plastic
response of the materials. Predict
the expected fatigue life of the
materials in the typical aerostructures.
Perform uniaxial and multiaxial
fatigue tests on the materials.
Conduct simulations of fatigue
crack growth of the standard
specimen models using the
newly generated coefficients and
properties (by using a Boundary
Element software package).
Establish the computer model
to evaluate the materials fatigue
life by considering interaction
of plasticity and fatigue models.
Determine axial and torsional
cyclic plastic responses of
materials under various loading
conditions using a software
package of finite element.
Important findings from this
research are plasticity models
for the evaluation and analysis
of the cyclic plastic response
and multiaxial fatigue life in the
proportional and non-proportional
loadings with different strain
paths by packages of FEM for
aerospace materials. Furthermore,
it will enhance the fatigue life
predictions. Thus the reliability
of machines and aerospace
structures under cyclic loadings
will be increased.
Possible High Impact Journals
for Publications
International Journal Of Fatigue;
International Journal Of Plasticity;
Engineering Analysis With
Boundary Elements;
Materials And Design; Engineering
Structures
Collaborators
Prof. M.H. Aliabadi, Chair in
Aerostructures, Department of
Aeronautics, Imperial College, UK.
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/ENG/34
Title: Coastal protection using Eco-Engineering
technologies
Principal Investigator: Prof. Ir. Dr. Roslan Bin Hashim
Department: Civil Engineering – Faculty of Engineering
Summary of Research Proposal
Sea level rise, increased global temperature and concentration of
atmospheric CO2, threaten the landward of the coasts through phenomena
such as sediment erosion, excessive inundation stress and increased water
salinity. Mangrove forests are indigenous inhabitants of coastal re-gions
in tropical and sub-tropical countries. They provide services for shore
ecology and human through protection and raw material. FAO estimated
that the total area of mangroves at 16.1 million hectares on 1990 decreased
drastically to 15.4 million hectares on 2010. This triggers an alarm for all
124 countries in the world which stated the existence of Mangroves in their
territory regardless of the volume. On the other hand, wave energy and
sediment loss can deteriorate the man-made infrastructures on-land ward
and sea-ward of the coasts.
The implementation of eco-friendly concepts in coastal protection
techniques to minimize envi-ronmental anthropogenic effects is still an open
question. Eco-engineering technologies reconcile man-made structures and
ecological features to solve the complicated brutal forces of nature.
Objectives
Methodology
Outcome
Minimization of coastal erosion
and rehabilitation of mangrove
forests, are the focal points of
this study. On the narrower scale,
it is intended to plan to design,
construct and monitor the effect
of various costal protection
structures such as revetment and
detached-breakwater system
on improvement of geotechnical
characteristics in land-ward
of coasts. Existing armoring
units called, “L-Blocks” (Roslan
Hashim et all [2010]) will be
modified in terms of structure and
mate-rial based on the nature of
usage. Sustainable Polymeric
Geosynthetic (SPG) will be used
as an innovative construction
material to increase structural
stability, lessen wave-induced
deformation and amplify effective
stress. Simultaneously, the
artificial mangrove replantation
will be carried out on provided
shelter area. Bathymetric data will
be collected throughout the study
to assess the effectiveness of the
project.
It is aimed to hire an interdisciplinary approach in this study.
Agriculture sciences, geotechnical
studies, knowledge of coastal
hydraulics, structural analysis,
innovative construction methods,
mathematical and statistical
analysis will be all involved in this
research. The kinematic wave
data, wind forecast and tidal
elevation table will be collected
from Malaysian Meteorology
De-partment. Geotechnical tests
including Mc.Probe, Triaxial test,
VCT, Altenburg Consistency lim-its
and volumetric physical, will be
carried out. Numerical modeling
using FEM and FDM will be
carried out by software such as
Plaxis, Abaqus and Mike 21 based
on the type of structure. Full-scale
bathymetric plans will be prepared
using delicate land-surveying
measures. Statistical analysis
for derivation of standard table
of design for modified L-Blocks
will be carried out based on
parametric and full-scale studies.
Other tests for construction
materials will be done according
to ASTM standards. Also various
mangrove replanting techniques
using different pattern and type
of distribution is aimed to be
performed to rehabilitate the lost
mangrove forests.
1.
To assess the effectiveness
of ecological methods in
coastal protection methods.
2.
Rehabilitation of deteriorated
mangrove forests in
endangered areas of
Peninsular Ma-laysia.
3.
Modification of existing
armoring units called ,
“L-blocks”
4.
To enhance near-shore
and on-shore geotechnical
characteristics.
5.
To construct detached
breakwater system and
revetment unit for dampening
of storm surges and wave
energy.
High Impact Research Annual Report 2012
Possible High Impact Journals
for Publications
Construction and Building
Materials ( IF : 1.834); Ecological
Engineering ( IF : 3.415) ; Journal
of Experimental Marine Biology
and Ecology( IF : 1.875) ; Estuaries
and Coasts ( IF : 2.109); Coastal
Engineering ( IF : 1.757); Climatic
Change ( IF : 3.385); Estuarine,
Coastal and Shelf Science ( IF :
2.247).
Collaborators
Dr. Roger A. Falconer, Professor,
Cardiff University, United Kingdom
Dr. Samsudin Taib, Associate
Professor, University of Malaya,
Malaysia
Dr. Zubaidah Ismail, Associate
Professor, University of Malaya,
Malaysia
Dr. Shatirah Akib, Senior Lecturer,
University of Malaya, Malaysia
Ahmad Mustafa Hashim ( M.Sc),
Associate Professor, University
Technology Petronas, Malaysia
Project No: UM.C/625/1/HIR/MOHE/ENG/35
Title: An Integrated Production Planning and Decision
Analysis System for SMEs
Principal Investigator: Assoc. Prof. Dr. Siti Zawiah Md. Dawal
Department: Centre for Product Design & Manufacture (CPDM)
Department of Engineering Design & Manufacture,
Faculty of Engineering
Summary of Research Proposal
According to SMIDEC report, there are 552,804 SMEs establishment in
Malaysia (Dato Hafsah Hashm, Cer-SMIDEC, 2009). More than 90% of the
SMEs are in manufacturing (Teh Kee Shin, President SME Association of
south Johor, 2009). To maintain competitiveness, future manu-facturing
companies including SME’s need to be flexible and adaptive in their
operating struc-tures. In this trend, a new solution tool dedicated to
help SMEs’ decision making in facilities and production planning that
accommodates turbulence demand, sustainable manufacturing as well as
operator safety and well-being is proposed.
Objectives
Methodology
Outcome
The main objective of this
research is to identify and
develop the system based on
the relevant factors to optimize
SMI’s production system on
turbulence demand, sustainable
manufacturing as well as operator
safety and well-being.
The research methodology is
conducted using the following
phases. In the first phase a survey
will be conducted to design
engineers in industrial companies
in order to get their views on
re-search implementation and
application from the industry
perspective. In the second phases
of this research a developing a
conceptual framework and model
in Eco Process Planning for Sustainable Manufacturing will be
developed.
New knowledge of humanmachine interaction model for
SME’s production in Malaysia.
Developing a methodology on
digital factory-based integrated
design approach for flexible manufacturing system and developing
a methodology on multi-level
optimization model for generalized production system layout and
scheduling planning
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High Impact Research Annual Report 2012
Possible High Impact Journals
for Publications
Applied Soft Computing,
Computers & Industrial
Engineering, Computers &
Operations Re-search, Robotics
and Computer-Integrated
Manufacturing
Collaborators
Professor Dr. Keith Case,
Loughborough University, United
Kingdom.
Professor Dr. Stephen Evans,
University of Cambridge, United
Kingdom.
Professor Dr. Masaru Nakano,
Keio University, Japan.
Professor Dr. Hideki Aoyama, Keio
University, Japan.
Professor Dr. Zahari Taha,
University Malaysia Pahang (UMP)
Project No: UM.C/625/2/HIR/MOHE/ENG/36
Title: Strengthening structural elements for load and
fatigue using advanced techniques.
Principal Investigator: Prof. Ir. Dr. Mohd Zamin Jumaat
Department: Civil Engineering
Summary of Research Proposal
Modern highway bridges are in serious need of rehabilitation as a result
of deteriorated structural components. Therefore, there is an urgent
requirement for development of inexpensive and unobtrusive rehabilitation
technique such as adhesive bonding or bolting steel or fiber reinforce
plastic(FRP) plates for reinforced concrete structure (Deric J. 2001).
Various loads such as stat-ic and fatigue loads can cause large cracks
and deflections which will reduce the durability of structures. Many bridge
structures in Malaysia which are subjected to repeated loads are now
carrying more loads than before and in need of strengthening. Extensions
of service life of these engineering structures not only save the economic
cost but also ensure sustainable development through reduction in energy
required to produce new materials for replaced structures as well as
minimization of disposal of old structures.
Objectives
Methodology
In specific terms, the study
focuses on studying the overall
behavior of plate bonded
strength-ened structural elements.
From this research effective
method for strengthening of
structural elements using plate
bonding method for loads and
fatigue will be developed. At the
end fatigue reliability analysis
of the strengthened structural
components will be carried out.
From the literature review,
effective materials and methods of
strengthening structural elements
under loads and fatigues will be
selected. The mechanisms of
premature debonding failures
will be identified. Based on
the mechanisms of premature
failures, design methods of
anchors will be proposed.
Methods of strengthening using
CFRP laminate to eliminate
IC debonding will also be
proposed. Finally, the technique
to conduct the experimental
works on specimens under loads
and fatigue will be identified.
The optimal dimensions of
strengthening plates based on
design method will be obtained.
Experimental works will be
carried out on un-strengthened
and strengthened structural
elements under loads and fatigue.
All structural elements will be
modeled using FEM package
software to compare the results
with experimental findings.
High Impact Research Annual Report 2012
Outcome
Proposing effective methods for
preventing premature failures of
strengthened structural elements. Recommendations for
effective method of strengthening
structural elements using plate
bonding method for loads and
fatigue. Development of FEM
for predicting the behaviour of
strengthened structural elements
under various load and fatigue.
Possible High Impact Journals
for Publications
1.
Engineering Structures
2.
Construction and Building
Materials
3.
Computers & Structures
4.
Composite Structure
5.
Journal of Civil Engineering
and Management
6.
Automation and Construction
Collaborators
Prof. Dr. Deric John Oehlers
(Deng., PhD., MSc, BSc. MIEAust)
Professor of Structural
Engineering
School of Civil, Environmental and
Mining Engineering
The University of Adelaide,
Australia
Project No.: UM.C/625/1/HIR/MOHE/ENG/37
Title: Modification Of Fenton Oxidation Pro-cess For
Treatment Of Recalcitrant Wastewaters
Principal Investigator: Professor Ir. Dr. Abdul Aziz bin Abdul Raman
Department: Department of Chemical Engineering
Faculty of Engineering
University of Malaya
Summary of Research Proposal
Pollution caused by wastewater containing recalcitrant contaminants can
cause severe envi-ronmental and health problems. Recalcitrant wastewaters
typically contain components like phenol, carboxylic compound and
others, which can be found in variety of wastewaters. Such wastewaters
include resin-producing factory discharges, textile wastewaters, petroleum
refinery wastewaters, metal working fluids and pharmaceutical effluents.
Advanced oxidation processes (AOPs) have been effective in treating
recalcitrant and non-biodegradable wastewater. One category of AOP
is the Fenton Oxidation. Various Fenton and improved-Fenton treatment
pro-cesses for recalcitrant wastewaters will be developed in this work. This
is a fundamental and application research where focusing on areas which
can contribute to wider application for eco-nomically treating recalcitrant
wastewater.
Objectives
Methodology
This research seeks to develop
enhancements on the treatment
capability of conventional Fen-ton
Oxidation process and to develop
a treatment system for selected
wastewaters at laboratory and
pilot scale.
The performance of Fenton
oxidation treatment will be
established using conventional
Fenton reagent for single
recalcitrant aromatic components.
Development of enhancers will
include alternative oxidants, novel
catalysts, catalyst improvements
and irradiation assistance. Kinetic,
performance and comparative
studies will be conducted to
model and optimise the process.
Models will be used to conduct
scale up studies and pilot scale
reactors will be designed to carry
out on-site testing. Integrated
technologies like advanced
membrane separation will also
be explored as a pre- or posttreatment step for AOP treatment
system.
Outcome
1.
New catalysts and enhanced
catalyst.
2.
Pilot scale mobile treatment
unit.
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High Impact Research Annual Report 2012
Possible High Impact Journals
for Publications
1.
Journal of Membrane
Science
2.
Chemical Engineering
Journal
3.
Chemical Engineering
Research and Design
4.
Chemical Engineering
Science
5.
Chemical Engineering Data
Collaborators
Professor Dr. Wan Mohd. Ashri
Wan Daud (Co-PI), Department of
Chemical Engineer-ing, Faculty of
Engineering, University of Malaya.
Professor Dr. Nik Meriam
Nik Sulaiman, Department of
Chemical Engineering, Faculty of
Engineering, University of Malaya.
Professor Dr. F. Handan Tezel,
Department of Chemical and
Biological Engineering, Faculty of
Engineering, University of Ottawa,
Canada.
Project No.: UM.C/625/1/HIR/MOHE/ENG/38
Title: Custom Based Development Of Bio And Chemical
Reactors Using Advanced Fluid Dynamic Studies
Principal Investigator: Professor Ir. Dr. Abdul Aziz bin Abdul Raman
Department: Department of Chemical Engineering
Faculty of Engineering
University of Malaya
Summary of Research Proposal
Stirred vessels can be found in almost all chemical manufacturing premises
and may outnumber other unit operations by far. Stirred vessels can be used
for various applications through combi-nation of mass, heat and momentum
transfer operations. The application can range from a sim-ple operation to
maintain uniformity of temperature or concentration or even to create high
mass transfer environments. This warrants a relook into the development
of systems with innovative designs, non-conventional vessels or agitation
configurations to adapt to specific applications. A complete mixing
technology testing facility will allow for a detailed finding on hydrodynamics
and mixing phenomena to be obtained. Furthermore, in Malaysia there are
more than 100,000 man-ufacturing industries that use stirred vessels for
various applications.
Objectives
Methodology
This research aspires to study
wide range of chemical and
biological reactor operation in the
laboratory by employing simulated
and actual conditions using state
of the art facilities. Through this
study, significant information in
the form of mathematical models
can be developed and tested for
various industries for achieving
higher efficiency through
advanced imaging, visualisa-tion
and simulation techniques.
A complete facility will be set up
to conduct mixing performance
studies system for various configuration of stirred vessel, types
of impellers for combinations of
phases available in the industry. This facility will be able to
perform in depth mass transfer,
heat transfer and hydrodynamic
studies for Newtonian, nonNewtonian and even high
concentration medium to replicate
various critical application of
mixing systems. Several systems
will be identified to conduct scale-
up and scale-down work in order
to generate reliable procedures to
generate mixing performance data
for industrial scale stirred vessels
for selected bioreactor and
chemical reactor application.
High Impact Research Annual Report 2012
Outcome
1.
A complete stirred vessel
test-centre for the country
or even at regional level.
(Currently, no such centre
exists in the region.)
Possible High Impact Journals
for Publications
1.
Renewable and Sustainable
Energy Reviews
2.
Reviews In Chemical
Engineering
2.
Novel impellers design.
3.
3.
New techniques for
power and mass transfer
measurement.
Chemical Engineering
Journal
4.
Computers & Chemical
Engineering
5.
Chemical Engineering
Science
Collaborators
Professor Dr. Shaliza Ibrahim
(Co-PI), Department of Civil
Engineering, Faculty of Engineering, University of Malaya.
Dr Rajarathinam Parthasarathy,
Civil, Environmental & Chemical
Engineering Depart-ment, Royal
Melbourne Institute of Technology,
Melbourne, Australia.
Project No: UM.C/625/1/HIR/MOHE/ENG/39
Title: Powering Up Paralyzed Muscles Using Functional
Electrical Stimulation (FES): An Advance in Rehabilitation
Engineering
Principal Investigator: Dr. Ahmad Khairi Abdul Wahab
Co-PI: Dr. Nur Azah Hamzaid, Dr. Nazirah Hasnan (Faculty of Medicine)
Department: Biomedical Engineering
Summary of Research Proposal
Functional Electrical Stimulation (FES) is a method that uses electrical pulse
to generate muscle contraction; its application can be roughly divided into
two categories: upper limb and lower limb. To restore the walking motor
function of the lower limb via FES is a hard job; however FES cycling
movement is relatively an easy task and can provide the foundation for FES
walking. Accordingly it can exercise the muscles, increase range of joint
motion and improve cardiopul-monary fitness. As a result of fast growing
technology and achievements in integrated electron-ics, there is significant
increase in the speed and complexity of modern microcontrollers. Using
new microcontrollers with integrated memory modules and peripherals,
it is possible to design single-chip controlled stimulators. The integrated
microcontroller modules can replace special-ized hardware circuits that
were typically applied in earlier designs. This research will also involve
the modeling of muscle-electrical responses, FES stimulator and system
development, mechanical and software development, patient rehabilitation
and intervention studies. While several research and clinical trials have been
conducted to establish several factors contributing towards effective FES
evoked cycling activity, such as the most suitable electrical current parameters, the optimal frequency, duration and intensity of training, as well
as integrated technol-ogy to effectively deliver the current to the targeted
paralyzed muscles, muscle fatigue is still the established barrier to effective
training. To date, there has yet to be established the most effec-tive ‘mode’
of cycling and the best possible use of surface or implanted sensory system
to deliv-er feedback to the FES system for optimum stimulation parameters.
Therefore, the prime expected novelty of this project is the development
of a new direct sensory system to identify evoked muscle performance
to optimally deliver current to the muscles. This sensor will contribute to
the lack of established muscle feedback during FES evoked exercise, to
eliminate or reduce fast muscle fatigue effect, which is a primary cause of
inefficient FES ex-ercise activity.
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High Impact Research Annual Report 2012
Objectives
This project will focus on the
following;
1.
To development of electronic
circuit for six-channel
functional electrical
stimulation.
2.
To develop the portable
multi-channel system
of functional electrical
stimulation (FES).
3.
To develop the programmed
multi-channel cycling and
exercise system.
4.
To develop a new sensory
system to monitor muscle
performance and fatigue for
opti-mized activity.
Methodology
At the early stage, FES
components review and
development are carried out
and followed by pulse tests on
biological muscles, component
integration and optimization. The
development of communication
modes with other integrated
exercise devices will be
formulated. Clinical trial runs and
patient evaluation session will
be used. Further tests such as
stimulation on muscle strength,
efficiency, endurance and others
will also be implemented to
test for reliability, effec-tiveness
and efficiency of the developed
devices. Clinical studies are also
being conducted to investigate
the effects of FES compared
to conventional intervention for
the target population. Finally, at
the identified milestones of the
project, publications are targeted
at the high ranked journals.
Outcome
New sensory and monitoring
system to identify evoked muscle
performance to optimally deliver
current to the muscles will be
developed. This sensor will
contribute to the lack of established
muscle feedback during FES
evoked exercise, to eliminate
or reduce fast muscle fatigue
effect, which is a primary cause
of inefficient FES exercise activity.
New method to deliver rehabilitation exercise, evaluation and
training system in practicing new
rehabilitation techniques to help the
disabled to exercise their paralyzed
muscle and provide possibilities
in having to do activities such as
normal persons do.
Possible High Impact Journals
for Publications
1.
Journal of Biomechanics
2.
Clinical Biomechanics
3.
IEEE Journal of Rehabilitation
Engineering & Development
4.
Biomedical Microdevices
5.
IEEE Signal Processing
Magazine
6.
Clinical Studies
7.
Advances in Applied
Mechanics
Collaborators
Prof. Dr. Glen M. Davis, Professor
of Clinical Exercise Sciences
Convenor, Exercise Health and
Performance Research Group
and Director, Clinical Exercise and
Rehabilita-tion Unit, Faculty of
Health Science, The University of
Sydney
Dr. Anwar Suhaimi, Prof. Madya
Dr. Lydia Abdul Latif, Dr. Aishah
Ahmad Fauzi, De-partment of
Rehabilitation Medicine, Faculty of
Medicine, University of Malaya.
Project No: UM.C/625/1/HIR/MOHE/ENG/40
Title: Nano-fluids in enhancing the performances of heat
exchangers
Principal Investigator: Professor Dr. Saidur Rahman
Department: Mechanical Engineering
Summary of Research Proposal
The nanofluid has superior heat transfer capabilities due higher thermal
conductivity compared to conventional fluids. In this work, Nanofluids will
be prepared and characterized using suitable methods and techniques.
Fundamental properties of nanofluids will be investigated along with heat
transfer performance in heat exchangers. A system will be developed
for the thermal performance investigation of heat exchangers (i.e. boiler,
solar collector, and electronics). Energy savings and emission reductions
are also expected with the application of nanofluids in heat exchangers.
Mathematical formulations/co-relation will be developed to estimate energy
savings and emission reduction associated with heat transfer enhancement.
High Impact Research Annual Report 2012
Objectives
Methodology
Outcome
1.
To prepare and characterize
nanofluids
2.
To investigate the
thermal and rheological
characteristics of nanofluids
Energy efficient heat exchangers
and publication in top quality
journal
3.
To investigate the thermal
performances/heat transfer
in heat exchanging devices
such, boiler, cooling of
electronics, improving solar
collector efficiency and etc
Nanofluids will be prepared
by using two step method.
Nanofluids will be characterized
by using sediment capture
method, TEM, FESEM, Zeta
potential, UV visible spectro
photometer, etc. The transient
hot wire method will be used to
measure the thermal conductivity
of nanofluids. Rotating viscometer
will be used to measure the
viscosity of. A density meter will
be used to measure the density
of nano-fluids. A differential
Scanning calorimeter (DSC) will
be used for measuring specific
heat of nano-suspension. The
experimental setup will be
developed to measure the heat
transfer, pressure drop, energy
and exergy analysis of heat
exchangers, solar collector and
electronic cooling.
4.
To estimate energy/
fuel savings along with
greenhouse gas reduction
Possible High Impact Journals
for Publications
1.
International Journal of Heat
and Mass Transfer
2.
International Communication
in Heat and Mass Transfer
Collaborators
Ryerson University, Canada (Prof.
Dr. Ziad Saghir)
Bangladesh University of
Engineering and Technology (Prof.
Dr. Md. Mustafizur Rah-man)
Razi University, Iran (Assoc. Prof.
Dr. Tooraj Yousefi)
Project No: UM.C/625/1/HIR/MOHE/ENG/41
Title: Exoskeleton Robotics Device For Limb Impairment
Support
Principal Investigator: Dr. Norhafizan Ahmad
Department: Centre of Product Design & Manufacture (CPDM),
Department Engineering Design & Manufacturing
Summary of Research Proposal
The design of this exoskeleton robotics device is primary use in rehabilitation
of the function of the human body, with segments and joints corresponding
to those of the person it is externally coupled with. This device has variety of
other application areas including rescue, military and recreational activities.
Although the supplementary technologies such as measurement and control have advanced vastly in recent times, there are still many challenges
related to the exoskel-eton and robotic assistive device development for the
progress in their improved and widespread usage. Recent advances have
also look into the application of exoskeleton robot in industry namely the in
tasks involving hazardous or heavy load.
Objectives
1.
To benchmark existing
market and technology as
well as the needs of local
demands of exoskeleton
robots for various individuals
and conditions.
2.
To provide optimal
database models of
human physiological and
biomechanical factors for
developing control strategy
and algorithm for the functions
of exoskeleton robot.
3.
To measure the performance
of exoskeleton robot for
increasing system efficiency.
4.
To develop a novel structure,
mechanism and system
approach for the functions of
exoskel-eton robot.
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High Impact Research Annual Report 2012
Methodology
Outcomes
The research is conducted using
three stages of development.
First stage is to conduct benchmarking studies on the current
technology in the market as
well as to determine the market
growth and demand of the
exoskeleton robots for limb
impairment support. In this stage
the study is investigated the
human physiology capability and
the biomechanical aspects for
the human movement as for the
database to develop the control
strategy of the device. For the
second stage, the control strategy
and algorithm for the complete
structure of the exoskeleton
robots is developed based on
existing requirement from the
first stage. The construction of
the control algorithm is used to
determine the optimal mechanism
movement for more realistic and
smooth device. The final stage
is to fabricate the structure and
mechanism for the exoskeleton
robots of the limb impairment
support. This design stage
includes sensing system to detect
the workload of the handling,
repeatability test for reliability of
the system devices, safety and
ergo-nomics factor for the design.
The purpose model is then tested
to the specific user in order to
improve the design from any
problem exist.
1.
2.
3.
4.
Locally made assistive
exoskeleton robot device and
components which comply
with Malay-sian standards
and safety.
Feasibility of a novel
mechanical design
configurations,new control
algorithm planning and
adaptibility of the system
interface between specific
local users and the
exoskeleton robot.
Build an engineering
database of Malaysian
biomechanical and human
physilogical resources
that can be accessible to
users of different levels and
conditions.
Promote links with local
hospitals and research
institutions for specific
exoskeleton robot of interest.
Possible High Impact Journals
for Publications
1.
Robotic and ComputerIntegrated Manufacturing
(ISSN: 0736-5845)
2.
European Journal of
Operation Research (ISSN:
0377-2217)
3.
International Journal of
Machine Tools & Manufacture
(ISSN: 0890-6955)
4.
Journal of Materials
Processing Technology
(ISSN: 0924-0136)
5.
Composites Part A – Applied
Science and Manufacturing
(ISSN: 1359-835X)
Collaborators
Prof. Dr. Zahari Taha, University
Malaysia Pahang (University
Malaysia Pahang, Malaysia)
Assoc. Prof. Dr. Tan Maw Pin,
University of Malaya Medical
Centre
Prof. Daisuke Kurabayashi, Tokyo
Institute of Technology, Japan
Assoc. Prof. Naomichi Ogihara,
Department of Mechanical
Engineering, Keio University,
Japan
Dr. Herianto, Gadjah Mada
University, Indonesia
Project No: UM.C/625/1/HIR/MOHE/ENG/42
Title: Design of Image Quality Metric and Pattern
Features for Multimedia Applications and Video based
Analysis
Principal Investigator: P. Raveendran
Department: Electrical Engineering
Summary of Research Proposal
Images are ubiquitous in modern communication, allowing us to transfer
information in many different forms (animated and static) and of different
content (humans, animals, places, objects) in different genres and
communication venues. To increase efficiency, a number of processes compression, transmission, enhancement and etc are used to transform
images for easier transmission; however these cause distortions to occur.
As human beings are the end users of the images and their evaluation
on the acceptability of the reproduction for their needs is still the critical
criterion, human subjective assessment of image quality is still regarded the
touchstone or benchmark of quality. Subjective assessment suffers from a
number of limitations that renders it less than perfect The current research
priority, therefore, has been with finding objective image quality metric using
orthogonal moments that most closely approximates this subjective evaluation.
High Impact Research Annual Report 2012
Objectives
Methodology
Outcome
The objective evaluation involves
designing a mathematically
defined metric that is low in
com-putational complexity,
independent of viewing conditions
and human observers. The
designed objective metric will
utilize orthogonal moments for
Full Reference and No reference
images.
The process begins with the
review of previous and latest
publications related to the study.
In the first phase of the research
methodology, literature reviews
will be conducted to identify
the existing algorithms, their
bottlenecks and limitations.
Formulation of new algorithms
that addresses some of these
limitations. The mathematical
formulation of digital filters
to generate both orthogonal
polynomials and moments will be
studied and implemented. The
results obtained will be compared
with the state-of-art methods.
Design of new image quality
metric based on orthogonal
moments, and design of digital
filters for generating orthogonal
polynomials and novel Image
processing solutions for
applications
Possible High Impact Journals
for Publications
1.
IEEE Trans. Image
Processing
2.
Pattern Recognition
3.
IEEE Trans. on Circuits and
Systems
Project No: UM.C/625/1/HIR/MOHE/ENG/43
Title: Hybrid Solar Electrochemical and
Bioelectrochemical Water Treatment Process Using
Activated Carbon
Principal Investigator: Professor Mohamed Kheireddine Aroua
Faculty: Department of Chemical Engineering
Summary of Research Proposal
Removing organic and inorganic pollutants from the water source is a
necessity in order to pro-tect the environment and human beings. Our
recent work at the Department of Chemical Engineering showed the
potential of palm shell based activated carbon as electrode material for
the electroreduction of heavy metals, electrooxidation, as well as the
bilelectrochemical remediation of nitrates. The main disadvantage of the
electrochemical based processes is the cost of electricity. In this project we
are proposing to develop a hybrid electochemical/bioelectrochemical-solar
system for mineral as well as organic pollutant removal from wastewaters. A
five year project is planned which will cover laboratory sacle as well as pilot
scale studies.
Objectives
Methodology
The objectives of this research
are to develop a laboratory
scale electrochemical and
bioelectrochemical processes
using solar energy as source of
electricity to remove selected
pollutants from wastewater and to
sclae up the process.
Phase 1 of the project consists
of laboratory scale experiments.
For this purpose, laboratory
scale upflow electrochemical
and bioelectrochemical reactors
will be constructed based
on our previously designed
reactors. The reactors will be
designed in such a way that
they can be operated batchwise
as well as continuously. The
electrode material will consist of
commercially available palm shell
activated carbon.A commercially
available photovoltaic system will
be purchased and combined with
the reactors. The data generated
during phase 1 of this project will
be used to scaleup the process.
A pilot scale treatment system
will be designed and constructed.
The system performance will
be evaluated using simulated
wasterwater as well as real
wasterwater samples.
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High Impact Research Annual Report 2012
Outcome
1.
2.
Waste to Wealth concept:
use of Palm Shell solid waste
as a source of Electrode Material. Added value to Palm
Shell based activated carbon
Possible High Impact Journals
for Publications
Bioresource Technology, Water
Research, Electrochimica Acta,
Journal of Hazardous Materials
Pilot plant to determine
commercial potential of the
hybrid process
Collaborators
Professor Geoff Howard Kelsall,
Imperial College London, UK
Dr. Umi Fazara Md. Ali (PhD
Imperial College London),
Universiti Malaysia Perlis,
Malaysia
Project No: UM.C/625/1/HIR/MOHE/ENG/44
Title: Regenerative Biomechanics of Human Body
Principal Investigator: Prof Ir.Dr.Wan Abu Bakar Wan Abas
Department: Biomedical Engineering, Faculty of Engineering
Summary of Research Proposal
The rapid movement in the field of regenerative biomechanics is the most
promising technology for side-stepping in one method both the complex
issues of stem-cell ethics and the expensive life-limiting consequences
of the metallic prosthesis. It is in understanding the complex biomechanical environments which exist within the human body, by providing
supportive structures and frameworks, and through precisely controlling
their biomechanical interaction that the pa-tient’s own cells can be used to
produce long-lasting, bio-compatible and ethically agreeable repairs.
The research therefore includes three major foci: Clinical biomechanics,
in particular the relation between forces at the macroscopic level and
those produced at the microscopic or cellular level; Cellular response
to changes in this biomechanical environment, particularly in terms of
ways in which tissue repair, remodeling, production and viability may be
produced or increased, via the development and/or fabrication techniques
to analyze the said cellular responses; and, investi-gation of other related
cellular interactions as low-power electrical field gradient, growth factors,
nutrient control or pharmaceutical agents both to improve regenerative
biomechanics and to enhance clinical rehabilitation strategies. This focus
may lead to the development of individual-ized cell characterization
techniques and/or applications.
Objectives
1.
2.
3.
To characterise the response
of individual cells to various
extracellular forces, both
transient and long term, in
real-time using markerless,
low-power electrical gradient
techniques
To characterise the
response of tissue to varied
expressions of biomechanical
loading both in sustained and
short term modes
To develop techniques,
technologies and protocols
to permit the efficient and
economically effective
Methodology
extension of regenerative
biomechanics toward the
clinical sphere
4.
To gain new and specialist
knowledge of the relationship
between gross biomechanics
and local tissue regenerative
processes
The research program will
comprise a multi-disciplinary
approach comprising major
and cutting edge methods
from various sectors. These will
include:
•
Real time PCR measurement
of tissue and cell genetic
expression
•
Live cell isolation and
culture technologies for
the evaluation and in vitro
testing of processes and
the interaction between
regenerative physiology and
biomechanics
High Impact Research Annual Report 2012
•
The use of specialised cell
lines or non-specialised cell
types
•
The production of theoretical
models hypotheses, their
evaluation through in vitro
and in vivo studies, and
iterative improvement of such
theories
•
•
•
Confocal microscopy and live
cell imaging to understand
detailed cellular interactions
which connect gross
biomechanical inputs to
tissue and cell level changes
in regeneration
Real-time, markerless
in vitro measurement of
cell electrophysiological
phenotype using inhouse AC electrokinetics
techniques
Segregation and sorting
of stem cells using AC
electrokinetics-based
microfluidics
Outcome
Collaborators
Specialist knowledge and a
leading group specialised in
regenerative biomechanics will
permit a much broader application
of this field, directly impacting
upon clinical applications,
pharmeceutical tie-ins and
potential benefits for quality of
life in general and particularly
with reference to recovery
from arthritis, osteo porosis,
spinal injury and other forms
of musculoskeletal adverse
pathology.
Professor Dan Bader, University of
Southampton, UK
Dr Tina Chowdhury, Queen Mary,
University of London, UK
Prof Walter Herzog, University of
Calgary, Canada
Professor Toshiro Ohashi,
Hokkaido University, Japan
Possible High Impact Journals
for Publications
1.
Journal of Biomechanic
2.
Biomaterials
3.
Journal of Orthopaedic
Research
4.
Lab on a Chip’
5.
Electrophoresis
Project No: UM.C/625/1/HIR/MOHE/ENG/45
Title: Corrosion and fouling mitigation for food industries
via modification of heat exchanger
Principal Investigator: Dr. Kazi Md. Salim Newaz
Department: Mechanical Engineering, Faculty of Engineering.
Summary of Research Proposal
Intensive studies have been done on the corrosion behavior of cooper in
acidic solution, neutral sodium chloride and alkaline solution. No much work
have reported on calcium sulphate and carbonate corrosion or fouling and
corrosion on copper and other heat exchanger materials in shear fields. In
this project, effect of surface energy on deposit formation on heat exchangers
used in cooling system and milk pasteurization will be investigated
experientially at different operating parameters on SS and other coated
surfaces (PTFE, AMC148, TM117P, CNT etc) along with modeling works.
Objectives
Methodology
Outcome
To generate data of corrosion
effect on copper, brass, SS,
nickel, coated surfaces etc. tubes
of heat exchangers. Fouling
tolerance of the heat exchanger
tube of different materials will be
studied. Modeling of corrosion
and fouling on heat exchanger
tubes will be performed.
Corrosion and fouling phenomena
will be studied experimentally
in the controlled environment.
Different types of solution at a
wide range of concentration along
with different test specimens will
be used in corrosion study. On
the other hand, different types of
coated heat exchanger materials
at a wide range of temperature
and flow rate will be used in
fouling experiments.
Corrosion data in mineral salts
enriched cooling water will
be generated. Fouling data of
protein and mineral salts on
heat exchanger surfaces in food
and chemical industries will be
acquired. Fouling resistant surface
coating will be selected and
model of fouling and corrosion will
be de-veloped.
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High Impact Research Annual Report 2012
Possible High Impact Journals
for Publications
1.
International Heat and Mass
Transfer,
2.
Journal of Thermal
Engineering,
3.
International Journal of
Thermal Science,
4.
Chemical Engineering
Journal,
5.
Applied Thermal Engineering
Collaborators
Professor Geoffrey G. Duffy, The
University of Auckland, Private
Bag 92019, Auckland, New
Zealand, Phone: 649-3737599
ext.87805, Email: [email protected]
auckland.ac.nz.
Professor Xiao Dong Chen,
Associate Dean International
(Engineering), Department of
Chemi-cal Engineering, Monash
University, Victoria 3800, Australia,
Phone: +61-3-9905-9344, Email:
[email protected]
Project No: UM.C/625/1/HIR/MOHE/ENG/46
Title: Reconfiguration of conduit geometry for heat
transfer augmentation of heat exchangers
Principal Investigator: Ahmad Badarudin Mohamad Badry
Department: Mechanical Engineering, Faculty of Engineering
Summary of Research Proposal
The separation flow generated by sudden expansion or contraction
in passage over steps in many different flow geometries such as heat
exchangers for augmentation of heat transfer. The investigation of the effect
of different geometries are yet to be done to find a conclusive result, thus in
the present research, data generation will be conducted along with modelling
of flow separation and reattachment, heat transfer enhancement etc.
Objectives
Outcome
Collaborators
Generate data and modeling of
augmentation of heat transfer
and friction loss due to flow
sepa-ration in different conduit
geometries.
Heat transfer and friction loss
characteristic data will be
generated. Develop correlation
between augmentation of heat
transfer and friction loss with
conduit configuration and
optimize the con-duit dimensions.
Develop model for heat transfer
and friction loss in customized
configured con-duits.
Professor Geoffrey G. Duffy, The
University of Auckland, Private
Bag 92019, Auckland, New
Zealand, Phone: 649-3737599
ext.87805, Email: [email protected]
auckland.ac.nz.
Methodology
The apparatus will be
designed and constructed to
have an axisymmetrical and
anaxisymmetric separated and
reattached flow in an annular
passage. The passage precedes
the upstream with a variable
test section. The apparatus can
provide different fluid velocity
(variable Reynolds number) and
heat flux at the test section.
Possible High Impact Journals
for Publications
International Heat and Mass
Transfer, Journal of Thermal
Engineering, International Journal
of Thermal Science, Chemical
Engineering Journal, Applied
Thermal Engineering
Professor Xiao Dong Chen,
Associate Dean International
(Engineering), Department of
Chemi-cal Engineering, Monash
University, Victoria 3800, Australia,
Phone: +61-3-9905-9344, Email:
[email protected]
High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/ENG/47
Title: Sustainable Ocean Energy and Waterway
Developments in the Straits of Malacca.
Principal Investigator: Associate Prof. Dr. Lam Wei Haur (CEng MIEI).
Department: Department of Civil Engineering.
Summary of Research Proposal
Marine Renewable Energy (MRE) is a new type of renewables compared
to the biomass, biogas, solar power and mini hydro in Malaysia. The
enactments of Sustainable Energy Development Authority Act 2011 and
Renewable Energy Act 2011 provide Feed-in-Tariff (FiT) to encourage the
development of renewable energies. Malaysia is a maritime country with
high coast/area ratio with potential to harness marine renewable energy.
Marine renewable energy includes tidal barrage, marine current energy, wave
energy, Ocean Thermal Energy Conversion (OTEC) and salinity gradient
power. Marine renewable energy has not been included in the FiT due to
the limited knowledge on this marine resource. This project investigates the
marine renewable energy associated with the waterway protection in the
Straits of Malacca.
Objectives
Outcome
Collaborators
Marine renewable energy and the
seabed damage due to ship’s
propeller wash are studied to
create knowledge in Malaysian
context. The study aims to
provide better understanding on
the development of marine current
energy in the Straits of Malacca.
The site selection, turbine de-sign,
maintenance, power transmission,
environmental impacts and cost
reduction are studied, whereas
the berthing load to harbour and
wake-induced load to waterways
are also investigated.
The project enhances the
knowledge of marine renewable
energy in Malaysia and provides
so-lution to the potential damage
due to ship berthing in harbours.
Queen’s University Belfast (Dr. GA
Hamill, Dr. DJ Robinson)
Methodology
The computational, experimental
and field studies are used to
investigate the problems of marine
renewable energy (MRE) and
waterways protection. The free
Computational Fluid Dynamics
package (OpenFOAM) is used as
a cost-effective approach.
Possible High Impact Journals
for Publications
1.
Ocean Engineering (Q1 in
JCR 2011, Civil Engineering
Discipline)
2.
Coastal Engineering (Q1 in
JCR 2011, Civil Engineering
Discipline)
3.
Renewable & Sustainable
Energy Reviews (Q1 in JCR
2011, 2011 Energy & Fuel
Disci-pline)
4.
Energy (Q1 in JCR 2011,
2011 Energy & Fuel
Discipline)
5.
Energy Conversion and
Management (Q1 in JCR
2011, Mechanics Discipline)
6.
J Atmos Ocean Tech
(Q1 in JCR 2011, Ocean
Engineering Discipline)
7.
Ocean Modelling (Q1 in
JCR 2011, Ocean Modelling
Discipline)
University of Plymouth (Dr. Ming
Dai)
Dalian University of Technology
(Dr. Ming Jia, Dr. Jiafei Zhao)
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/ENG/48
Title: Study Of Partial Discharge Characteristics Within
Voids In Dielectric Materials With Nanofillers
Principal Investigator: Dr. Hazlee Azil Illias
Department: Electrical Engineering
Summary of Research Proposal
Partial discharge (PD) may cause breakdown of an insulation material
when the repetition of PD events within a defect is very high, which causes
chemical and physical deterioration of the in-sulation. When breakdown of
the insulation occurs, breakdown of the whole high voltage com-ponents
may occur. To study a new insulation system, a dielectric material filled
with nanofiller is proposed. Nanofillers studies have been on-going since
the last decades. However, research on PD characteristics within a void
in a nanofiller/dielectric material is not widely published. Therefore, in this
project, measurement of PD activity will be performed on test samples
consist-ing of a void in an epoxy resin filled with different nanofillers. A
model of a void in a solid dielec-tric insulation material filled with nanofillers
will also be developed using finite element analysis (FEA) software. The
model will be used to simulate PD activity within a void in a nano-filler/
dielectric material and is compared with the measurement results.
Comparison between measurement and simulation results will lead to a
new knowledge on how partial discharge ac-tivity is influenced by the
introduction of nanofillers in a dielectric material. New parameters from the
simulation model, which play significant roles in affecting partial discharge
behaviour, can be identified.
Objectives
Methodology
1.
To attain a better
understanding of PD within
voids in nanofiller/dielectric
insulation material
2.
To develop a simulation
model of PD activity a void
in a solid dielectric material
using FEA
3.
To compare the influence
of different nanofiller
within epoxy resin on PD
characteristics
4.
To investigate the influence
of the different void
conditions on PD events
in nanofiller/epoxy resin
insulation material
Once research background has
been done sufficiently, a model
geometry of a void located in
a solid dielectric material filled
with nanofillers will be developed
using COMSOL Multiphysics
software. The model will be
used to simulate electric field
distribution in the model geometry
and PD activity occurring within
the void. Once the model that
has been developed can be
simulated successfully and the
simulation results are reasonable,
experiments are ready to be
performed in the high voltage
laboratory. Initially, test samples
for PD activity measurement
will be built. The test samples
will consist of a spherical void
of various sizes and positions
located in a nanofiller/dielectric
material. In the experiment, the
materials that will be used are
Alumina/epoxy resin and Silica/
epoxy resin. Different conditions
of the PD experiment that will be
performed on the test objects are
variation in the applied voltage
amplitude, applied frequency,
material temperature, void sizes
and different density, dispersion
and types of nanofiller within
the material. After experiments
5.
To identify key parameters
from the FEA model that
influence PD behaviour
within a void in nanofiller/
dielectric materials through
comparison between
simulation and measurement
have been performed, simulation
of PD activity within voids will
be performed to reproduce
measurement results that
have been obtained from the
experiment. In this step, the
model that has been developed in
COMSOL Multiphysics software
will be inter-faced with a MATLAB
programming code for a better
flexibility in handling the model.
Outcome
1.
How does partial discharge
phenomenon behave within
a void in a dielectric material
l filled with nanofillers under
different conditions of stress
and void
2.
How is partial discharge
behaviour within a void in an
insulation material of power
cable geometry filled with
nanofillers
High Impact Research Annual Report 2012
Possible High Impact Journals
for Publications
1.
IEEE Electrical Insulation
Magazine
2.
IEEE Power and Energy
Magazine
3.
International Journal of
Electrical Power and Energy
Collaborators
Prof. George Chen, Electrical
Power Group, University of
Southampton, United Kingdom
Dr. Azrul Mohd Ariffin, Universiti
Tenaga Nasional, Malaysia
Assoc. Prof. Dr. Zulkurnain
Abdul-Malek, Universiti Teknologi
Malaysia, Malaysia
Project No: UM.C/625/1/HIR/MOHE/ENG/49
Title: Central Advanced Research Enabler Facility
(CAREF)
Principal Investigator: Associate Prof. Dr. Faisal Rafiq Bin Mohamd Adikan
Department: Dean Office
Summary of Research Proposal
This is a proposal for the setting up of an advanced engineering research
ENABLER facility in the Faculty of Engineering. The facility will be a focal
point for several flagship Ministry of Higher Education funded High Impact
Research (MOHE HIR) projects, providing a common enabler platform for
researchers to push research onto another level of complexity.
The vision is that the Faculty’s flagship researches such as biomedical
engineering, photonics, advanced microelectronics, and renewable energy,
involving technologies such as biosensors, MEMs, microfluidics, integrated
optical chips, solar panels and harvesters, would benefit from a common
facility which would otherwise be obtained via separate funds. The facility
will be a central lab, administered by Faculty appointed members of staff.
Objectives
Methodology
Collaborators
To avoid duplication and
researchers working in silos, the
Faculty proposes a central enabler
facility that would result in these
projects gaining access to similar
essential equipment.
To have an advanced laboratory
equipped with cleanrooms facility
Not Applicable
The objectives of such facility are:
1.
To attract first class
students and good external
candidates.
2.
To attract collaborations and
consortium.
3.
To encourage highimpact publication and IP
generation.
4.
To provide international
standard teaching and
professional training facility.
Outcome
An advanced laboratory.
Possible High Impact Journals
for Publications
Publications within the field
of biomedical engineering,
photonics, advanced
microelectronics, and renewable
energy, involving technologies
such as biosensors, MEMs,
microfluidics, inte-grated
optical chips, solar panels and
harvesters.
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/ENG/50
Title: Physiological Control of an Implantable Rotary
Blood Pump.
Principal Investigator: Dr. Lim Einly
Department: Engineering.
Summary of Research Proposal
One aspect of continuous flow rotary blood pumps (RBPs) that is still in its
infancy is its appro-priate control to cater for variations in metabolic demand
and hence cardiac preload. In order to maximize the quality of life of the
implant recipients so that they could regain a normal lifestyle in a long term
unsupervised environment, it is believed that a pump control strategy which
au-tomatically adjusts the pump speed to cater for changes in metabolic
demand is needed.
Objectives
Outcome
Collaborators
The objective of the present
project is to develop a control
strategy that is to be able to adapt
and respond quickly to varying
metabolic demand normally
encountered by the patients in
real life, as well as to promote
myocardial recovery.
Development of control strategies
that are to be able to adapt
and respond quickly to varying
metabolic demand normally
encountered by the patients in real
life, as well as to promote myocardial recovery.
Siew Cheok Ng, University
Malaya, Malaysia
Possible High Impact Journals
for Publications
Chee Kok Han, University Malaya
Medical Centre, Malaysia
Methodology
A mathematical model will
be developed to evaluate the
physiological interaction between
the RBPs and the circulatory
system under a wide range of
operating conditions, using
a numerical model, a mock
circulatory loop and in vivo animal
studies. The model will then be
used to design and implement
appropriate physiologically
responsive control strategies for
the RBPs. The performance of the
control algorithm will be evaluated
using the mock circulatory loop
and in vivo animal studies.
1.
IEEE Transactions of
Biomedical Engineering
2.
Artificial Organs
Suhaini Kadiman, National Heart
Institute, Malaysia
Mohd Nazeri, National Heart
Institute, Malaysia
Nigel H Lovell, University of New
South Wales, Sydney
Socrates Dokos, University of
New South Wales, Sydney
John Fraser, The Prince Charles
Hospital, Brisbane
Daniel L Timms, The Prince
Charles Hospital, Brisban
High Impact Research Annual Report 2012
RESEARCH PROPOSAL
(HIR-MoHE 4 Years)
Faculty of Dentistry
Project No: UM.C/625/1/HIR/MOHE/DENT/09
Title: Discovery of Single Nucleotide Polymorphisms
(SNPs) for Oral Cancer prognostication Using Genomewide Association Study (GWAS) and the Development of
Protein Biodiagnostic Marker for Early Detection of Oral
Cancer
Principal Investigator: Associate Professor Dr. Chen Yeng
Department: Dental Research and Training Unit, Faculty of Dentistry
Summary of Research Proposal
Cancer association studies comparing frequencies of genetic
polymorphisms between cases and controls, offer a powerful approach
to identify variants. A genome wide association study (GWAS) approach
proposed in this study allows the use of high throughput technologies
towards identifying novel regions/markers and pathways associated with
carcinogenesis by screening through genetic markers of 100,000 or more
across the entire human genome using a large number of specimen.
In an effort to increase the specificity of the diagnosis of OSCC, a concurrent
study using an immune-proteomic approach will be an extension of the main
project to look for significantly reliable biomarker(s) or a diagnostic test that
individually or in combination with other markers for oral cancer detection
and/or monitoring its progression. Besides these, the findings will also lead
to the discovery of some basic but interesting information on functional
cellular processes in human host systems towards cancer cells.
Objectives
Methodology
With the use of high throughput
technologies, we aim to detect
single nucleotide polymorphisms
(SNPs) in oral cancer patients
and normal control and identify
allelic polymorphisms which are
associated with oral cancer. In
concurrent with this, through
proteomics and immunological
ap-proach, we aim to detect
immunogenic host tumor protein
using human antibodies, and
identify those differentially
glycosylated proteins, and the
proteins which have possible links
to oral can-cer. We also hope to
identify potential protein marker(s)
for oral cancer progression and
its ef-fectiveness and also to
confirm and compare the common
protein biomarker(s) of oral cancer
progression using whole human
saliva, serum and tissue. And lastly,
we hope to identify new binding
partners, binding affinities, the
kinetics of binding and understand
the function of the selected protein.
A GWAS in 30 Malaysian oral
cancer patients and 30 healthy
controls obtained from Oral
Can-cer Research & Coordinating
Centre (OCRCC) will be
conducted. These samples will
be se-quenced using exome
sequencing. Identification
and correction for population
stratification for quality control
will then be conducted. The
association between each SNPs
identified and oral cancer will
be assessed using a suitable
statistical method. After the
identification of the lead SNPs;
the exons, the 3’-UTRs and the
promoter will be sequenced in a
subset of samples.
The protein and immunological
studies will be conducted with
saliva, serum and tissue samples
of oral squamous cell carcinoma
(OSCC) samples which will be
obtained from OCRCC. In attempts to investigate potential
biomarker(s) of OSCC, two
dimensional electrophoresis (2DE) followed by Western blotting
of the three samples from affected
individuals and normal healthy
individuals will be compared.
Characterization of those proteins
of interest will later be subjected
to mass spectrometry analysis
using MALDI-TOF TOF.
Physiologically relevant proteinprotein interaction studies
will be carried out on those
selected proteins using a Coimmunoprecipitation (Co-IP)
technique. And finally the protein
of interest will be isolated and
crystalized to confirm the changes
of structural conformation.
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High Impact Research Annual Report 2012
Outcome
Collaborators
From this study we hope to
be able to identify biomarkers
on SNPs profile for genetic
variation on oral cancer and be
able to establish biomarkers for
prognostication that could benefit
the clinical management of oral
cancer patients in the longer term.
We hope the findings could be
applied in diagnostic and targeted
drug therapy for personalized
medical treatment.
Prof. Dr. Rosnah Mohd Zain,
Department of Oral Pathology,
Oral Medicine & Periodon-tology,
Faculty of Dentistry, UM
Possible High Impact Journals
for Publications
1.
Molecular and Cellular
Proteomics
2.
International Journal of
Cancer
3.
Oral Oncology
4.
Head & Neck
5.
Cancer Epidemiology,
Biomarkers and Prevention
Dr. Marhazlinda Jamaludin,
Faculty of Dentistry, UM
Dr. Thomas George, Department
of Oral Pathology, Oral Medicine
& Periodontology, Faculty of
Dentistry, UM
Karen Ng Lee Peng, Oral Cancer
Research & Coordinating Centre
(OCRCC), Faculty of Dentistry, UM
Wan Maria Nabillah Wan Abd
Ghani, Oral Cancer Research &
Coordinating Centre (OCRCC),
Faculty of Dentistry, UM
Dr. Ha Kien Onn, Oral Maxillofacial
Surgery, Faculty of Dentistry, UM
Prof. Naoyuki Kamatani, RIKEN
Center for Genomic Medicine,
Japan
MOH collaborators, Oral Health
Division Ministry of Health
Malaysia
Project No: UM.C/625/1/HIR/MOHE/DENT/10
Title: Nutrigenomics and phospholipid signalling in oral
cancer: Nutrient-gene interactions
Principal Investigator: Professor Ian Paterson
Department: Dental Research and training Unit, Faculty of Dentistry
Summary of Research Proposal
Oral squamous cell carcinoma (OSCC) is the sixth most common
malignancy reported worldwide. The global number of new cases is
estimated at approximately 400,000 per annum, with about two-thirds of
cases arising in developing countries.
Although there have been significant improvements in chemotherapy
and surgical techniques, OSCC is often particularly challenging to treat
since most patients present with advanced dis-ease. The 5-year survival
rate of around 50% has not improved in the past four decades. There
is a compelling need to develop novel therapeutic strategies and to
identify clinically relevant biomarkers to stratify patients for the most
appropriate treatment. This is likely to be achieved only through a complete
understanding of the specific molecular events that underpin the development and progression of the disease.
High Impact Research Annual Report 2012
Objectives
Methodology
Outcome
We will investigate which genes
and pathways related to nutrient
metabolism are deregulated in
OSCC and examine the function
of nutrient-gene interactions in the
pathogenesis of OSCC. The role
of two bioactive phospholipids,
LPA and S1P, in the development
and progression of OSCC will
be analyzed in detail. We aim
to identify how the expression
of genes associated with
phospholipid metabolism and
signalling (enzymes, GPCRs,
second messengers etc) are
deregulated in OSCC and
whether specific components of
these pathways can be targeted
therapeutically.
Gene expression profiling will
be used to identify genes and
pathways related to nutrient
metab-olism. The function of
nutrient-gene interactions and
the effect of LPA and S1P on the
behaviour of OSCC cells will be
examined using a variety of in vitro
and in vivo assays of malignancy.
To examine the specific function
of individual genes we will use
shRNA and lentiviral technologies
to stably knock down gene
expression. Therapeutic
antibodies and chemical inhibitors
of LPA and S1P signalling will be
used to assess the potential of
components of the phospholipid
sig-nalling pathways as novel
therapeutic targets for OSCC.
New knowledge of genes that are
involved in nutrient metabolism
and how nutrients influence gene
expression in OSCC.
A fuller understanding of how
bioactive lipids, LPA and S1P
influence the development and
progression of OSCC, how
their signalling receptors are
deregulated and how the lipid/
receptor axis might be targeted
for the treatment of OSCC.
Possible High Impact Journals
for Publications
1.
Journal of Nutrition
2.
Oncogene
3.
Journal of Pathology
4.
International Journal of
Cancer
Collaborators
Oral Health Division, Ministry of
Health, Malaysia.
Professor Paul Murray, University
of Birmingham, UK.
Dr Max Robinson, University of
Newcastle, UK.
Project No: UM.C/625/1/HIR/MOHE/DENT/11
Title: Optical Assessment of Enamel and Dentine Deand Remineralisation
Principal Investigator: Dr Chew Hooi Pin
Department: Department of Conservative Dentistry, Faculty of Dentistry
Summary of Research Proposal
Dental caries is a complex disease. Over the last several decades, a number
of measurement criteria have been developed to identify the presence of
dental caries. New diagnostic tools are needed for the characterization
of dental caries in the early stages of development. If carious lesions are
detected early enough, they can be arrested without the need for surgical
interven-tion.
Dentistry has shifted towards the concept of ‘Minimally Invasive Dentistry’
that allows maximal preservation of healthy tooth structure. However,
caries prevention, caries arrest and preserva-tion of tooth structure are now
possible with the advent of Adhesive dentistry.
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High Impact Research Annual Report 2012
Objectives
1.
2.
3.
4.
3.
Early Enamel Erosion (E1)
•
Translation of optical
diagnostic methods into
clinical use.
Explore other novel objective
decision-making aids.
Establishing local prevalence
data for general and erosive
wear.
Development of regional
expert research team in
oral hard tissue de- and
remineralisa-tion.
•
The project is divided into 5
sub-projects and they are as
delineated below:
Methodology
1.
Early Primary Enamel Caries
(C1)
•
•
2.
In vitro Characterization
of Optical Coherence
Tomography (OCT) data
for fissure caries and
Visualization of caries
under restoration
Scoring of teeth
samples will be done
according to ICDAS
0,1,2 followed by
im-aging with digital
radiography and
OCT imaging before
and after restoration
placement(fissure
sealant) and comparing
with Gold standard
PLM.
Validation of the use
of OCT in vivo in
detection of primary
and secondary caries.
Dentinal Caries (C2)
•
Validation of the use
of OCT in vitro in
the determination of
infected and af-fected
dentine
•
In vivo validation of
OCT technique in the
longitudinal monitoring
of early enamel erosion
Optical coherence
tomography
measurements will be
performed using the commercially available
Thorlabs OCT system
In vivo validation of
Quantitative Lightinduced Fluorescence
(QLF) in the longitudinal monitoring of
early enamel erosion
QLF analyses will be
conducted following a
set of predetermined
rules (Pretty et al.,
2002) in terms of patch
placement.
Detection of dentinal
erosion in vitro using
QLF and OCT.
4.
Prevalence of Erosive Wear
locally and its associated
Risk Factor (E2a)
5.
Validation of Longitudinal
Monitoring of Erosive Wear
with OCT (E2b)
Possible High Impact Journals
for Publications
•
Caries Research Journal
•
Journal of Dentistry
•
Journal of Dental Research
•
Journal of Community
Dentistry and Epidemiology
•
Journal of Gastroenterology
•
Journal of Biomedical Optics
Collaborators
International Collaborators:
Professor Angus Walls - University
of Newcastle upon Tyne , UK
Professor Roger Ellwood –
University of Manchester, UK
Professor Iain Pretty - University
of Manchester, UK
Dr Christian Zakian - University of
Manchester, UK
Co Researchers:
Datin Dr Rashidah Esa
Dr Maria Angela Garcia Gonzalez
Outcome
Dr Azwatee Aziz
•
Novel and Objective
decision-making aid
Dr Sadna Rajan
•
Reduce costs and discomfort
for patients
•
Public Health monitoring tool
•
Stunting of the Restorative
Cycle
Dr Norasmatul Akma
Dr Prema Sukumaran
Dr Mohideen Salihu Farook
Dr Erum Zain
Dr Madiha Habib
High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/DENT/12
Title: Quality of life assessment in dental practice:
Assessing change in quality of life using the Oral Health
Impact Profile by establishing the Minimal Importance
Difference (MID)
Principal Investigator: Assoc. Prof. Dr. Roslan Saub
Department: Department of Community Dentistry, Faculty of Dentistry
Summary of Research Proposal
The focus of health care has shifted from being disease oriented to
emphasizing wellness and the maintenance of the quality of life of the
patients and population. This has led to change in the approach of care
from being clinician-centered to patient-centered care. As such, clinical
assessment alone has no longer sufficient to ensure quality care. Thus,
dental practitioners should include assessment that captures patients’
concerns. One such measures available and can be used for the Malaysian
population is S-OHIP (M) 1. This measure has been widely used in
epidemiological and clinical research. However, such measure has not been
widely used in clinical practice since there are very limited studies that have
been conducted to assess the ability of this measure, especially in detecting
change in dental practice. As a health care pro-vider, we would like to see
our patient recovers from the disease and more importantly improves their
quality of life as a result of the therapy rendered. However, despite the wide
acceptance and use of OHRQoL measures, interpreting changes in OHRQL
after therapy remains a chal-lenge to both investigators and clinicians. To
be effectively used these measures in dental prac-tice we require a clear
guidelines on how to interpret such measure especially to detect change.
Researchers have suggested that the most effective way of describing and
interpreting change in OHRQL is through the establishment of what is known
as minimal important difference (MID)2.
Objectives
Methodology
Outcome
1.
To assess oral health-related
quality of life (OHRQoL)
among the partially
edentulous patients before
and after providing a new
partial denture.
The minimal important difference
(MID) value for the partial denture
rehabilitation therapy will be
established, to be used in the
clinical practice and also clinical
research.
2.
To assess the voluntary bite
force of the patient before
and after providing partial
den-ture.
A purposive sample of the partially
dentate adult patients will be
selected from Faculty of Dentistry Universiti of Malaya, Universiti
Teknologi Mara (UiTM) and
Universiti Sains Islam Malaysia
(USIM). Patients will be given
the S-OHIP(M) to be completed.
Voluntary bite force and chewing
performance will also be recorded.
S-OHIP(M) will be administered
again and voluntary bite force
and chewing performance will be
recorded after completion of the
treatment at a follow-up clinic visit
4-6 weeks thereafter. In addition
to that, the global transition
scale will be also admin-istered
to perform the anchor based
technique. Data analysis will be
done using distribution based
and anchor based technique
with global transition scale and
voluntary bite force as an-chors.
3.
To establish an estimate of
MID of S-OHIP (M) in dental
patients, in order to facilitate
its interpretability.
Possible High Impact Journals
for Publications
1.
Community Dentistry and
Epidemiology
2.
Quality of Life
3.
Community Oral Health
Collaborators
Universiti Teknologi Mara (Dr.
Tengku Fazrina bt Tengku Mohd
Ariff, Pn. Rohaya Rah-man)
Universiti Sains Islam Malaysia (Dr.
Norlela Yacob, Pn. Ummu Anisah
bt Abdul Rahman)
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/DENT/13
Title: Study of the Craniofacial Form of the Normal And with Anomalies of
Malaysian Population using 3-Dimensional Imaging
Principal Investigator: Associate Professor Dr Siti Adibah Othman
Department: Children’s Dentistry & Orthodontics
Summary of Research Proposal
Visualization and analysis of craniofacial features of patients are involved
in diagnosis and treatment planning particularly in the field of orthodontics.
Due to several limitations of the con-ventional methods, three-dimensional
techniques such as 3D CT scan, laser surface scanning and stereophotogrammetry has been explored.
Planning an improvement of craniofacial anomalies patient’s facial
appearance requires guide-lines on some kind of general set of facial
proportions. This approach is practical in identifying the need of surgical
correction in patients with anomalies after comparative assessment is performed according to the norms established for specific group.
Objectives
Methodology
Outcome
1.
Target population would include
the cleft lip and palate patients
attending the Combined Cleft Lip
and Palate Clinic at Faculty of
Dentistry ,University of Malaya.
For Down’s syndrome patients,
visit to the Down’s syndrome
centre will be planned for sample
collection. Patients with other
abnormalies who come for
treatment at Dental Faculty will
also be included. For normal
subjects, it will be recruited from
the normal walk –in patients
attending the clinics at the
Faculty of Dentistry, University of
Malaya. All 3D facial scans were
captured using the M5 Cranio 360
Vectra 3D Face System (Canfield
Scientific Inc). The captured
images were then displayed
and analyzed using 3D Mirror
Software.
Establishment of anthropometric
norms related to craniofacial
region for the Malaysian population.
2.
3.
To obtain quantitative
information concerning
the three-dimensional
(3D) arrangement of the
craniofacial features of
subjects with craniofacial
anomalies in Malaysia
To compare the craniofacial
features of craniofacial
anomalies patients with
normal sub-jects in Malaysia
To develop a database that
will store all 3D images of
the study subjects with
craniofacial anomalies in
Malaysia.
Derive useful guidelines in
the treatment of patients with
craniofacial anomalies.
Possible High Impact Journals
for Publications
1.
Journal of Dental Research
2.
Clinical Oral Investigation
Research
3.
Journal of Medical Image
Analysis
4.
IEEE Transactions on Medical
Imaging
5.
Journal of Bioinformatics
High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/DENT/14
Title: Optimization Of Fabrication Techniques For Novel
Functionally Graded Dental Post And Its In-Vitro And InVivo Evaluation
Principal Investigator: A/P Dr. Hadijah Abdullah
Department: Conservative Dentistry, Dental Faculty
Co-Principal Investigator: Prof. Dr. Noor Hayaty Abu Kasim
Department: Conservative Dentistry, Dental Faculty
Summary of Research Proposal
Endodontically treated teeth restored with dental posts tend to be
susceptible to root and coronal fracture during function. Commercially
available posts are either rigid or flexible along its length as they are
fabricated from homogenous materials. The ideal post would be one that
exhibits different properties at the different length of the tooth, from the
coronal to the apical region.
Three novel formulations of functionally graded dental posts system
has been patented. These dental post matches the high stiffness at the
coronal region and its stiffness gradually reduced apically. A study on these
prototypes functionally graded dental posts (FGSP) in extracted bo-vine
teeth showed that FGSPs exhibited several advantages in terms of stress
distribution and fracture resistance compared to posts fabricated from
homogeneous material.
‘Functionally graded materials’ approach has been shown to be useful in
designing a new gen-eration of new dental post. However, the optimum
fabrication technique has to be identified to produce FGSPs of suitable sizes
for the human dentition in a commercial scale.
Objectives
Methodology
Outcome
Biocompatibility, optimization of
fabrication technique, fracture
resistance and fracture mode of
novel FGSPs will be compared
to their commercial counterparts.
The bond strength when cemented with various luting
cements in extracted human teeth
and thermal properties will be
evaluated. The treatment outcome
of these new post used to restore
in single rooted teeth need to be
studied in a clinical trial.
Fabrication of novel dental posts
based ZrO2, Ti, Al2O3 and HA
powders, through drying blending, mixing and milling process.
Optimization of fabrication
technique either using microinjec-tion moulding or diamond
grinding will be evaluated. The
biocompatibility and toxicity
will also be evaluated. An invitro study on 100 root treated
extracted upper incisors will
be carried out to investigate
the fracture resistance, thermal
properties, bond strength and
mode of failure. The boding
strength will be then evaluated.
Finally the survival rate of these
new functionally graded dental
posts will be evaluated clinically.
A novel dental post systems for
the restoration of endodontically
treated teeth.
One PhD and one Master students
Possible High Impact Journals
for Publications
1.
Journal of Dental Research
2.
Dental Materials
3.
Journal of Dentistry
4.
Interntional of Endodontic
Journal
5.
Journal of Endodontics
6.
Biomaterials
Collaborators
Prof. Dr. Hien Ngo, Faculty of
Dentistry, Kuwait University,
Kuwait
BTS Distribution Germany
(Industry partner)
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/DENT/15
Title: In vitro microbiological and tissue culture studies
for healthcare products
Principal Investigator: Assoc Prof Dr Fathilah Abdul Razak
Department: Oral Biology
Summary of Research Proposal
The oral cavity is a dynamic ecosystem consisting of both biotic and
abiotic components that interact between them in a balance manner under
the normal, healthy condition. In such a dy-namic relationship, alteration
to one of its component may often disturb the other and eventually if left
unattended, may lead to the onset of oral diseases such as dental caries
and periodontal diseases. The use of oral health care products has become
a necessity to maintain the health of the mouth.
The increase in awareness of the public against the use of chemicals and
alcohol in oral health care product has created an opportunity for research
involving natural resources. The develop-ment of such products for human
consumption however needs to meet certain requirement. Confirmation and
validation on the safe use of compound/s obtained from these natural resources must be based on sound scientific data. For that, relevant laboratory
testing and clinical trials need to be carried out to produce supporting data
and provide adequate information before a compound can be promoted as
an active component in oral health care products.
Objectives
Methodology
The study aims to evaluate the
effect of extracted compounds
from various local plants on the
oral ecosystem and with the
information gathered, formulate
extract-based preparations with
antiplaque/antifungal/salivastimulating/anticancer/wound
healing activities that can be used
to maintain oral health.
At the early stage, the biological
properties of these extracts and
compounds which includes pH,
fluoride content, phenols content
and the stability (selves-life)
of the extracts on storage are
being determined. Studies on
their antibacterial and antifungal
activities will then follow to
explore the effect of the extracts
and compounds on the microbial
component of the dental plaque.
During the initial stage of dental
plaque formation, adhesion of
microorganisms to the tooth
sur-face is important to ensure
colonization of the tooth surface
is secured. Thus the effect of
the extracts/compounds on
the adhering properties of both
oral bacteria and candida to
saliva-coated hard surfaces
will be looked into. An extract/
compound that is able to deter
colonization of these microbes
to the hard surface would be
promoted as an antiplaque
agent. Other proper-ties that are
of interest include to study the
responses of soft oral tissue to
the ex-tracts/compounds and
this work will involve the use of
oral cell lines and tissue culture
tech-niques. The effect of the
extracts/compounds on both
oral cancer cells and normal
oral fibro-blasts will be used to
indicate the responses of oral
cells on exposure to the extracts/
compounds. Other aspects
of interest include responses
of oral fluid such as saliva in
the presence of the respective
extracts/compounds. Finally the
collected data will be used to
formulate various preparations
for the purpose of oral health
maintenance.
High Impact Research Annual Report 2012
Outcome
A comprehensive approach in the
search of active compounds for
use as adjuncts in oral health care
products is important considering
the dynamic interactions between
the various compo-nents in the
oral ecosystem. The integration
of collected data obtained from
various aspects of the study will
be systematically analyzed to
produce oral health care products
that are effective.
Possible High Impact Journals
for Publications
1.
Journal of Dentistry
2.
Journal of Oral Diseases
3.
Antimicrobial and
chemotherapy journal
Collaborators
Natural Product Research Centre,
UiTM Puncak Alam
Project No: UM.C/625/1/HIR/MOHE/DENT/16
Title: Microscopy and Physiological Studies on the Effect
of The Oral Healthcare Products on The Oral Ecosystem
Principal Investigator: Prof Madya Dr Marina Mohd Bakri
Department: Oral Biology, Faculty of Dentistry
Summary of Research Proposal
The formation of biofilms is a natural process and can be controlled through
regular toothbrush-ing to prevent the formation of dental plaque which
is associated with the development of caries and periodontal diseases.
A formulated oral health product containing local plant extracts with
antibacterial properties will be tested for its effects on teeth and tissue
culture models as this will be crucial before the product can be used by
the public. The bacterial protein responsible for the interaction between
the bacteria and the host during biofilm development will be anlysed in this
study. The formulated oral health care product will be also be tested for its
side effect on tooth specimens.
Objectives
Methodology
1.
To determine the effects of a
formulated oral health care
products on teeth,
2.
To determine the effects of a
formulated oral health care
products on the expression
level of dysregulated genes
in ORL48 and KB cancer cell
line,
Preparation of selected local plant
extracts will be carried out using
the boiling method. Saliva from
patients will be collected before
the start of the experiment and
after using the mouthwash for two
weeks. Patients will be required to
rinse for 20 seconds, twice a day
for two weeks and the collected
saliva be used for assessment of
enzymes tests.
3.
To determine the salivary
enzyme activity of patients
exposed to the formulated
oral health care products.
The selected plant extracts will
be tested on two oral squamous
cancer cell line (OSCC) types;
ORL 48 and KB cell line. Extracts
of different plants will be tested
for it’s cytotoxic effects on the
cell lines using the Neutral Red
Assay. Optimum concentration
of the cytotoxicity test will be
a parameter for downstream
procedure that would be revolving
around the analysis of gene regu-
lation. Besides that, five different
genes of five particular cancer
pathways and two housekeeping genes were selected to be
analyzed for its regulation using
qRT-PCR.
Outcome
Better understanding of the effect
of the oral health care products
on the cancer cell lines and when
consumed by patients.
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High Impact Research Annual Report 2012
Possible High Impact Journals
for Publications
1. Planta medica
2. Journal of ethnopharmacology
3. Anti microbial and
environmental microbiology
4. Journal of oral microbiology
5. Critical review of oral biology.
Collaborators
Dr Wan Himratul Aznita bt Wan
Harun
Prof Dr Zubaidah Haji Abdul
Rahim
Assoc Prof Dr Fathilah Abdul
Razak
Dr Sarni Mat Junid
Puan Zubaidah Abu Hassan
Prof Dr Richard Cannon
Assoc Prof Dr Alison Rich
Dr Ann Holmes
Project No: UM.C/625/1/HIR/MOHE/DENT/17
Title: Effect of Plant Extracts on the Expression of
Genes Responsible for the Colonisation of Dental Plaque
Microorganisms.
Principal Investigator: Dr. Wan Himratul Aznita Binti Wan Harun.
Department: Department of Oral Biology, Faculty of Dentistry
Summary of Research Proposal
The pathogenesis of oral candidiasis is closely dictated by the formation
of biofilms of Candida species in the oral cavity. Candidal adherence on
the host surfaces is known as the first step for candida colonization, and
becoming more resistant to antifungal agents including amphotericin
B, fluconazole and itraconazole. The ability of Candida spp. to switch
from unicellular yeast to long and continuous tubules hyphae has been
considered as an important factor for the interactions with host.
The increasing bacterial resistance to conventional antimicrobial agents
has lead many researchers to search for natural products with antimicrobial
activity including the ability to reduce bacterial colonization resulting in
reducing dental plaque formation. Combination therapy
is one approach that can be used to improve the efficacy of antimicrobial
therapy. Our previous studies have shown that seven oral candida species
namely C. albicans, C. dubliensis, C.glabrata, C.krusei, C.lusitaniae, C.
parapsilosis and C.tropicalis were highly susceptible to the aqueous extract
of P. betle. In this study, purified hydroxychavicol from P. betle was evaluated
in vitro against a selected group of oral cavity pathogens.
Objectives
This project was design to identify
the genes of dental plaque
bacteria which are affected
as being demonstrated by
the reduce colonization ability
following exposure to the local
plant extracts. In this project, we
explored the antifungal activity
of hydroxychavicol against
medically important Candida
spp, and examine the synergistic
effects when hydroxychavicol is
combined with commonly used
antifungal agents. Our studies
also addressed to study the
pathogenicity of hyphal transition
form of selected Candida spp.
through investigation of their
biological characteristics and
molecular genetics.
High Impact Research Annual Report 2012
Methodology
Outcome
Active compound was purchased
from Sigma Aldrich and the
Minimal Inhibition Concentration
(MIC) and Minimal Bactericidal
(MBC) was determined and
validated according to the
microdilution method of the CLSI
(formerly NCCLS) (M27-A). Seven
strains of Candida species, in
this study are purchased from
The American Type Culture
Collection (ATCC), USA. For
hyphal transition study, serum
in combination with YPD as
growth media was used as the
induction agent. Morphological
changes were observed through
light and electron microscopy.
Susceptibility of yeast and hyphae
form against antifungal agents
was tested using microdilution
broth method. Hyphal
development study was carried
out using germ tube formation
test through microscopy and
spectrophotometry. Synergistic
effect of antifungal agent in
combination with commercialized
drug (Amp B) against Candida
spp. was performed using
microdilution method and effect
of antifungal agent on the ultra
structure of Candida spp. will be
studied through microscopy and
spectrophotometry analysis. Gene
expression will be determined
through quantitative PCR.
Screening for antifungal activities
on several local plants which
include Piper betle, brucea
javanica, ginger, galangal, garlic,
henna, shallot, tarragon were
carried out, and it was found
that Piper betle, brucea javanica,
garlic, shallot and tarragon’s
aqueous extract exhibited
antifungal activities towards all
seven candidal strains tested
in the study. Following that, the
positive extracts have been sent
for bioactive profiling to determine
the bioactive compounds.
Meanwhile, bioactive compound
of hydroxychavicol from Piper
betle exhibited an inhibitory effect
on all seven candidal strains
tested (MICs of 31.25 to 1000
μg/ml) with a minimal fungicidal
concentration which was twofold
greater than the inhibitory
concentration. Hydroxychavicol
showed a potent antifungal effect
in combination with Ampothericin
B which is FIC value is <0.5
for C.albicans, C.glabrata and
C.tropicalis.
This study has also showed
C.albicans, C.parapsilosis and
C.tropicalis to be positive for germ
tube formation when induced in
50% Fetal Bovine Serum (FBS)
(v/v) of Yeast Peptone Dextrose
(YPD) broth media at 37°C. The
filamentous form was more
resistance relative to the normal
yeast cells. Ability of yeast cells
to form germ tube was inhibited
and its growth rate has been
reduced to approximately 30%
by the antifungal agents’ activity
of chlorhexidine gluconate. In
concise, study has shown that
transition activity of Candida
cells contribute to its resistance
towards antifungal agent.
Possible High Impact Journals
for Publications
1.
Journal of Molecular
Microbiology and
Biotechnology
2.
Oral Microbiology and
Immunology
3.
International Dental Journal
4.
Phytomedicine
5.
Journal of
Ethnopharmacology
Collaborators
Faculty of Medicine, UM
Faculty of Applied Science, UiTM
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/DENT/18
Title: Assessing the oral health needs of Malaysian
indigenous population and development of a new dental
health education strategy
Principal Investigator: Dr. Nor Himazian Mohamed
Department: Department of General Practice and Oral and Maxillofacial
Summary of Research Proposal
Oral health is integral to overall health and wellbeing, with poor oral health
and untreated oral conditions having a deleterious impact on quality of life.
Oral health problems such as caries, periodontal disease, gingivitis, dental
abscess and oral mucosal abnormalities may cause a great deal of pain and
distress among population especially in children. If left unattended they may
result in severe problems with eating, growth, speech, and behaviour.
Malaysian indigenous comprised of the Orang Asli in the West Malaysia.
Majority of them live in the remote and some in the fringe urban after
rehabilitation plan. Some of them accesses public dental services either by
static dental clinic or mobile dental squad providing by the gov-ernment of
Malaysia.
Oral health status relates to common oral health diseases and the more
severe ones which relate to cancer and dental-facial pain. Available studies
have shown there is a changing trend in diseases prevalence between the
indigenous who are rehabilitated into the mainstream and those who are
remained to lead the traditional lifestyle.
Despite the advancement in dental treatment and technologies, the
indigenous group tended to receive less oral health care compare to the
general Malaysian population due to their attitudes, locations (accessibility)
and lack of oral health literacy. Dental exposure and education of the
indigenous children and parents with regards to prevention is essential. In
oral health con-text, literacy can be considered as the skills necessary for
people to understand the causes of poor oral health, to learn and adopt
fundamental aspects of positive oral self-care behaviours, to communicate
with oral health care providers, to place their names on dental treatment
waiting lists or organize appointments, to find their way to the dental
clinic, to fill out the necessary forms and to comply with any required
regimes, including follow-up appointments and compliance with prescribed
medication. Oral health literacy is required to promote oral health and to
prevent oral disease. It has also been proposed that health literacy may be
associated with barriers to accessing care, oral health behaviours such as
prevention and to follow-up care
Objectives
1.
To collect data on the oral
health status of children and
adult of indigenous group
in Be-lum, Perak and other
parts of Perak and thus
determine their treatment
needs.
2.
To assess the dental
knowledge and attitudes of
indigenous children’s and
parents/carers.
3.
To assess the effects of
poor oral health towards
indigenous children
nutritional intake, body
Methodology
weight, growth and quality
of life.
4.
To determine the problems
and impact of oral facial pain
on their quality of life.
5.
To develop a new Dental
Health Education package
1.
Research approval from
Medical Ethics Committee
of Faculty of Dentistry,
University of Malaya and
Jabatan Hal Ehwal Orang Asli
Malaysia
2.
Several visits and clinical
examination of the
Orang Asli in Belum,
Perak and other parts in
Perak will be conducted.
Prior arrangement and
communication with Jabatan
Hal Ehwal Orang Asli and Tok
Batin incharge of the area will
be sought out before the visit.
High Impact Research Annual Report 2012
3.
4.
5.
6.
For all cases, consent
will be obtained from
the participants or their
parents. Sociodem-ographic
information and data about
oral care habits and previous
visits to dental services
will be gathered from the
participants/ parents. Data
on dental knowledge and
attitudes will be obtained
through interviews by the
investigators.
Questionnaire survey will be
conducted on oral problems
and impact of facial pain on
their quality of life.
For children, body weight
and height will be measured
and compared to the WHO
child growth standards and
as well child growth charts
from Malaysian studies.
Clinical oral examination will
be carried out to determine
the oral health status by assessing the following:
a.
DMFT/dmft and
treatment needs
b.
Oral hygiene index and
Community Periodontal
Index (CPI)
7.
8.
c.
Plaque score at 4 sites
per tooth (for children)
Possible High Impact Journals
for Publications
d.
Bleeding on probing
(BOP) at 4 sites per
tooth (for children)
1.
Asia-Pacific Journal of Public
Health
e.
Oral mucosal lesion (for
adult)
2.
Community Dental Health
3.
Community Dentistry and
Oral Epidemiology
4.
Journal of Dental Education
5.
International Journal of
Paediatric Dentistry
Dental photography, 3D
Imaging and impression will
be taken among the adults
and children above 7 years
old.. Dental cast will be
fabricated subsequently.
Assessment of the oral
health literacy from the
questionnaires.
Collaborators
Ministry of Health Malaysia
Outcome
Data collection on the oral health
status and the survey will provide
informations to the Jabatan Hal
Ehwal Orang Asli Malaysia and
the Ministry of Health Malaysia
on their treatment needs. Thus
getting them some projections
on expenditure in provision of
dental services to orang asli group
in Malaysia. Dental education
package developed at the end of
the research will be useful as a
teaching aid for the target group.
Project No: UM.C/625/1/HIR/MOHE/ DENT/19
Title: Anatomical structural variations in the maxillofacial
region
Principal Investigator: Prof Dr Phrabhakaran Nambiar
Department: Faculty of Dentistry
Summary of Research Proposal
The oral cavity is an important area as it has a sgnificant role in mastication,
esthetics, speech, respiration and facial growth of an individual. With
increased rehabilitation of this area, there is a need to find whether there
are any anatomical variations of structures of this area. These include
determination of root and canal morphology of teeth, variations in position
of the nerves, structural variations of bony supporting tissues and the
topography of the floor of the maxillary sinus. We also intend to extend
the research to include the study of teeth of Orang utans. Skulls of these
primates (obtained with permission from Zoo Negara) will be imaged and the
necessary measurements taken. Subsequently metrical and non-metrical
relationship with human teeth and the supporting structures will be studied
to see any genetic affinity.
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High Impact Research Annual Report 2012
Objectives
Methodology
Outcome
1.
To determine the variations
of antomical structures in the
maxillofacial region.
2.
To provide accurate metrical
measurement of some
anatomical structures and
their standard deviations.
3.
To determine if there are any
variations because of gender,
race and ageing process.
Clinical application of this new
knowledge will useful during the
treatment of patients. Particularly
it will be relevant when
performing dental implantology,
root canal treatment or surgical
procedures in the maxillofacial
region. Root canal morphology of
Orang utans might reveal similarity
to human root canal system.
4.
To study in detail root and
canal morphology of Orang
utans and find any similarity
with human dentition.
These studies are possible
because we have images of
patients recorded by two ConeBeam Computed Tomography
(CBCT) machines at the Faculty of
Dentistry. These machines provide
high quality image resolutions
and measurements are metrically
accurate. We have also devised a
novel method to image individual
teeth so that it is possible to
make detailed studies of them.
Orang utan skulls obtained from
Zoo negara will be images for
detailed study of their root and
canal morphology. We also have
the SimPlant software which
allows the viewing of the axial,
cross-sectional, panoramic and
3D visualization of the jaws in the
same screen on the computer
monitor.
Possible High Impact Journals
for Publications
1.
Journal of dental research,
2.
Journal of veterinary
dentistry,
3.
Journal of anatomy,
4.
Journal of Morphology,
5.
Clinical antomy.
Collaborators
NA
Project No: UM.C/625/1/HIR/MOHE/DENT/20
Title: Study of host immunogenic and post-translational
modified proteins in schizophrenic patients and oral
health condition of the patients.
Principal Investigator: Associate Professor Dr. Chen Yeng
Department: Dental Research and Training Unit, Faculty of Dentistry
Summary of Research Proposal
Schizophrenia is a pervasive neuropsychiatric disease of uncertain
cause. It can affect both children and elderly but mostly seen in the age
group of 15-35 years interfering the most pro-ductive period of life and
resulting in prolonged suffering. Clinical presentation of schizophrenia is
convoluted as there is no single symptom or symptom cluster is considered
pathognomonic. The current diagnostic method for schizophrenia solely
depend on the considerably subjective assessment of symptoms as there is
no empirical method to validate the diagnosis of the disease and molecular
mechanism underlying the disease yet to be fully understood. Therefore, it is
important to reveal and understand the unknown of the underlying functional
changes at cellular level; in spite of the fact that the disease involves
interaction of multiple genetics and envi-ronmental risk factors.
High Impact Research Annual Report 2012
Objectives
Methodology
By using a proteomics and
immunological approach on
serum of schizophrenic patients,
we hope to identify potential
protein marker(s) specifically for
schizophrenic patients and those
dif-ferentially N-glycosylated
and O-glycosylated proteins
expressed in the sera of
schizophrenic patients as well
as to investigate the correlation
between schizophrenia and
oral health of the patients to
better understand the underlying
mechanism of the disease.
Protein profiles of the patients will
be investigated, immunogenic
and glycosylated proteins will
be identified and analysed both
qualitatively and quantitatively
differences. Methods to be
applied in the study include TwoDimensional Gel Electrophoresis,
Western Blot, MALDI-ToF-ToF and
ELISA.
Outcome
This study would also shed
information on human distinctive
immunology feature related to
schizophrenia and as a mean
to drive development of new
diagnostic and therapeutic
method.
Possible High Impact Journals
for Publications
1.
PLOS One
2.
Molecular and Cellular
proteomics
3.
Journal of Proteome
Research
4.
Proteomics
Collaborators
Associate Professor Dr.
Ahmad Hatim, Department of
Psychological Medicine, University of Malaya
Dr. Emelia Osman, Department
of Parasitology and Medical
Entomology, Universiti Kebangsaan Malaysia.
Project No: UM.C/625/1/HIR/MOHE/DENT/21
Title: Novel Tissue Expander To Facilitate Maxillary
Expansion In Treating Crossbite And Transverse Maxillary
Hypoplasia
Principal Investigator: Prof. Madya Dr. Zamri Radzi
Department: Children Dentistry And Orthodontics
Summary of Research Proposal
This proposal is to examine the use of a novel anisotropic tissue expander
(1) as a medical de-vice that will significantly improve patient outcomes
in the surgical treatment of crossbite, (2) improve our understanding of
mucosal expansion (3) improve our understanding of maxillary bone
development. Crossbite afflicts 7-10% of the Malaysian population. It is
a condition where the widths of the dental arch bases are incorrect, and is
very painful. A range of devices will be obtained, characterized and trialed in
a sheep model. The optimized device will be trialed in a small scale human
clinical trial. Concurrently, detailed observations from these in vivo studies
will increase our understanding of soft and hard tissue development.
Objectives
1.
To obtain certain mechanical,
physical and thermal
characteristics of different
types of the devices in order
to correlate it with animal and
clinical findings.
2.
To assess the viability of
a novel anisotropic tissue
expander based on coated
hydrogels for maxillary
expansion. These series of
studies are also designed
to meet the regulatory
requirements (specifically
CE marking in the EU and
FDA approval in the US) for
a Class IIb medical device
prior to commercialization
activities of the novel tissue
expand-er.
3.
To assess the rate and
direction of expansion of
the novel tissue expander
in the human maxilla and
to evaluate the changes in
dimension of the hard and
soft tissues using Cone Beam
Computed Tomography
and to determine the long
term stability of novel tissue
expander.
4.
To compare the novel
method with current standard
methods of expansion and
assess patients’ acceptance
and Quality of Life.
5.
To determine the long term
stability of novel tissue
expander.
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High Impact Research Annual Report 2012
Methodology
Few different types of the devices
and the biological tissues will
be studied from the mechanical,
physical and thermal point of
view. Mechanical properties of
the sheep palatal tissues and the
swelling parameters generated
by the expanders will be studied
using Dynamic Mechanical
Analyzer. Atomic force microscope
will be used to characterize
different ultrastructures in bulk
samples for each set of palatal
tissues. Materials’ composition,
phase and form will be studied
using Differential scanning
calorimetry and differential thermal
analyzer to ensure that it behave
as intended for the purpose of
process validation. All of the data
obtained will be correlated with
the animal and clinical findings.
The 3R’s principles have been
considered in every planned
procedure. It is estimated that
each group will consist of
approximately 5 animals per
treatment in order to obtain a
significance level of 5% and a
power of 80%. Approval will be
sought from the Animal Care and
Use Committee (ACUC) of the
Faculty of Medicine, University of
Malaya.
A prospective control clinical
trial will be carried out to
compare the novel method with
current standard methods of
expansion. Suitable participant
will be recruited following a
strict inclusion and exclusion
criteria. The participant will go
through a similar procedure as
the participant in case studies.
The participants will be monitored
longitudinally. In addition,
the psychological, patients’
acceptance and Quality of Life will
be assessed. Participants will be
followed up for an assessment of
short term and long term stability
of novel tissue expander.
Suitable patients will be screened
at the Orthodontic New Patient
Clinic, University of Malaya. Strict
inclusion and exclusion criteria will
be employed. Selected patients
will be recruited to participate
in the case study programme.
Consent form will be obtained
prior to the study.
A prospective control clinical
trial will be carried out to
compare the novel method with
current standard methods of
expansion. Suitable participant
will be recruited following a
strict inclusion and exclusion
criteria. The participant will go
through a similar procedure as
the participant in case studies.
The participants will be monitored
longitudinally. In addition,
the psychological, patients’
acceptance and Quality of Life will
be assessed. Participants will be
followed up for an assessment of
short term and long term stability
of novel tissue expander.
Outcome
A novel tissue expander patented
and will be used on crossbite and
transverse maxillary hypo-plasia
patients in Malaysia. 3 PhDs and 4
MSc graduate will be produced.
Possible High Impact Journals
for Publications
1.
Journal of Dental Research
2.
Biomaterials
3.
Dental Material
4.
Journal of Dentistry
5.
Journal of American Dental
Association
6.
Clinical Oral Implantation
Research
7.
Journal of Material Science
8.
Journal of Biomechanics
9.
Journal of Periodontology
10. Oral Surgery, Oral
Medicine, Oral Pathology,
Oral Radiology, and
Endodontology
Collaborators
David Jackson (Oxtex Limited,
Oxford Centre for Innovation, New
Road, Oxford OX1 1BY)
High Impact Research Annual Report 2012
RESEARCH PROPOSAL
(HIR-MoHE 4 Years)
Faculty of Computer Science and Information Technology (FCSIT)
Project No: UM.C/625/1/HIR/MOHE/FCSIT/08
Title: Human-Robot Interaction (HRI) Algorithm in Robotbased Intervention of Elderly with Alzheimer’s Disease
Principal Investigator: Dr. Chan Chee Seng
Department: Artificial Intelligence, FCSIT
Summary of Research Proposal
While robots have been used for social interaction, there is great untapped
potential for their use as therapeutic social partners. This research provides
a process by which a socially assistive robot can be developed and used
as part of a therapeutic intervention for elderly with Alz-heimer’s disease
(AD), elderly who have severe deficits in forgetfulness, depression and
social withdrawal behavior. This work is focused on robots whose behavior
encourages and facilitates social behavior in elderly with AD through
embodied social interaction.
Objectives
Methodology
1.
A novel robot architecture designs
specifically for social intervention,
examining the resulting humanrobot and human-human social
behavior, and comparing that
behavior to human-human social
behavior will be proposed. In
particular, effective and efficient
algorithms for multimodal analysis
and interpretation of human
deceptive behaviour that can
take into account non-linear
correlations between multimodal
cues (facial expressions, head
and body gestures, and various
vocalizations) in space and time
will be investigated.
2.
To explore how to employ
swarm intelligence +
particle filtering information
to effectively represent a
specific activity patterns and
environments models.
To explore how to reason
fuzzy qualitative trigonometry
+ description logic to identify
fa-cial segments for effective
HRI.
Outcome
•
Application: Human - robot
interactions for elderly
healthcare
Possible High Impact Journals
for Publications
1.
IEEE Transactions on Fuzzy
Systems
2.
Pattern Recognition
Collaborators
Prof. Dr. Paolo Remagnino,
University of Kingston, U.K.
Dr. Dorothy Monekosso, University
of Ulster, U.K.
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/FCSIT/09
Title: Efficient Green Operational Rescue Using Vehicle
Ad Hoc Technology
Principal Investigator: Dr. Rafidah Md Noor
Department: Faculty of Computer Science and Information Technology
Summary of Research Proposal
A vehicular network is a kind of wireless networks that has emerged in
wireless technologies and the automotive industry. Vehicular networks are
formed between moving vehicles equipped with wireless interfaces that
could be of homogeneous or heterogeneous technologies. These networks,
also known as VANETs (Vehicular Ad-hoc Networks), are considered as
one of the ad-hoc network real-life applications, enabling communications
among nearby vehicles as well as between vehicles and nearby fixed
equipment (roadside equipment). Vehicles can be either private, own by
individuals or private companies, or public means of transport (e.g., buses,
public service vehicles such as police cars, fire trucks, helicopters, trains,
etc.). A rescue unit operation is a challenging experience in helping any
incidents involved in urban areas and rural areas. The rescue unit team
requires efficient and reliable communications for each operational rescue
involved. The rescue unit team would be able to share an incident location,
share the incident cases via video or voice streaming, forward a medical
information, etc. A general architecture based on the concept of rescue
unit community is developed. A vehicle area network is created through
when the related equipments are connected inside the rescue unit vehicle.
Each rescue unit vehicle will communicate in 1000 metres radius to create
a Vehicle Ad Hoc Network (VANET). In specific scenario, such as urban
(high density) areas, the rescue unit vehicles create a team and perform the
operation rescue.
Objectives
Methodology
The aim of this research project is
to provide an efficient operational
rescue unit in vehicular networks.
There are four objectives to
achieve:
First, it aims to identify green
metrics for operational rescue
using vehicular networks. The
study seeks to explore the
operational rescue conducted in
Malaysia. The interview data will
be sup-plemented by the analysis
of documents. Second, the
project utilizes the green metrics
as a measurement tool to identify
the efficiency of the rescue
operation. There are several steps
tak-en to achieve this objective
where the understanding of the
vehicular technology such as
physi-cal layer, data link layer and
network layer.
a.
b.
c.
d.
e.
To investigate the operational
tasks among the rescue units
and identify their activities
involve in the rescuing
situations.
To propose a framework
that provides an efficient
opreational rescue for
different scenarios (i.e. urban
and rural areas).
To implement visualization
system to access information
enable rescuers to respond
to the incidents more
efficiently with better
situational awareness.
To implement a vehicular
network testbed by using the
wireless special equipments
that provide real time
communication among the
rescue unit.
To analyze the operational
rescue through the green
indicator performance.
Outcome
Better understanding of operation
rescue in Malaysia through their
generic model.
Green metrics and development
of routing algorithm can be used
to measure the efficiency of the
operation rescue.
Possible High Impact Journals
for Publications
1.
IEEE TRANSACTIONS ON
VEHICULAR TECHNOLOGY
2.
IEEE TRANSACTIONS
ON INTELLIGENT
TRANSPORTATION
SYSTEMS
3.
TRANSPORTATION
RESEARCH PART
C-EMERGING
TECHNOLOGIES
4.
IEEE COMMUNICATIONS
SURVEYS AND TUTORIALS
5.
IEEE TRANSACTIONS ON
MOBILE COMPUTING
6.
AD HOC NETWORKS
7.
IEEE WIRELESS
COMMUNICATIONS
Collaborators
Dr. Chih Heng-Ke, Department
of Computer Science and
Information Engineering, No.1,
University Rd., Jinning, Kinmen.
Taiwan.
Dr. Christopher Edwards,
Lancaster University, United
Kingdom
High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/FCSIT/10
Title: Mirror Neuron and Quantum Mechanics Based
Neural Architecture for Humanoid
Principal Investigator: Prof. Dr. Loo Chu Kiong
Department: Artificial Intelligence, FCSIT
Summary of Research Proposal
A grand challenge for robotics is establishing “friendly” and social interaction
between robots and humans. Due to the diversity of actions/tasks to be
performed and the range of possible interactions with objects and humans,
it would be impractical (if not impossible) to explicitly pre-program a robot
with such capabilities. Instead, such systems must be able to learn by themselves what tasks to execute and how they should be performed, which
requires sophisticated motor, perceptual, and cognitive skills. In this project,
we will address further challenge to apply the Quantum Mechanics based
neural structure for humanoid.
Objectives
Methodology
Outcome
1.
We will use Darwin-OP humanoid
and Nao H25 with laser head to
realize self-localization and social
communication with a human
and robot-robot interaction. The
robot has an embeded CPU
and many sensors, such as a
CCD camera, microphone which
enable the robot to perform
image processing (WP1), voice
recognition, target tracking and
imitative learning (WP3). In this
project, the robots use perceptual
modules for various modes
of image processing, such as
differential extraction, human
detection, object detection, and
human hand-motion recognition.
We will use Microsoft Speech
SDK for voice recognition and
synthesis in the robot [8]. It was
able to perform voice recognition
using a sound segment network
that made speaker-independent
recognition possible. After that,
the robot selects the conversation
mode from: 1) scenariobased conversation; 2) usual
conversation; and 3) learning
conversation.
Quantum mechanics based mirror
neuron model for elderly assistive
humanoid
2.
To develop a quantum
mechanics inspired neural
architecture for online
associative learning based
on intentional interaction
with humans by means of
body gestures and visual
information.
To develop mirror neuron
based online imitative
learning model that abstracts
the whole-body motions as
symbols, generates motion
patterns from the symbols,
and distinguishes motion
patterns based on the
symbols.
Possible High Impact Journals
for Publications
IEEE Transactions on Neural
Networks and Learning System,
International Journal of Neural
Systems, Applied Soft-computing
Collaborators
Prof. Dr. Naoyuki Kubota, Tokyo
Metropolitan University, Japan
Prof. Dr. Hideyuki Takagi, Kyushu
University, Japan
Mr. Noel Tay Nuo Wi, Multimedia
University
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/FCSIT/11
Title: Scientific Mapping and Research Assessment of
STEM Scholarly Communications
Principal Investigator: Assoc. Prof. Dr Abrizah Abdullah
Department: Library & Information Science
Summary of Research Proposal
The assessment of research performance in the scientific disciplines has
caught the attention of the university community for a long time. The most
crucial asset of a university is its reputation, and research is the playing
field where reputations are made. It is important to study trends in research
productivity because universities account for basic research which is one of
the main-springs of industrial innovations. The RM14.1b (USD4.2b) allocated
to the Ministry of Higher Education in 2009 under the 9MP was a further
indication of the importance that the govern-ment places on research. A
systematic assessment of Malaysia’s research performance how-ever is
not available. As such studying the performance and impact of Malaysia
in very specific or emerging scientific fields against that of the world and
and leading countries in the field need to be investigated through detailed
evaluation technique of scholarly communication.
Objectives
Methodology
The overall objective of this
research is to scientometrically
position the world’s performance
in a broad and specific emerging
STEM fields and how are the
leading countries and Malaysia
positioned in the studied areas.
It also develops indicators or
model to enable the production
of statistics on STEM research
productivity not yet defined by
existing indexing systems.
This research employs
bibliometrics methods to
derive new insight from
existing databases of scientific
publications. It uses mathematical
formulas and statistical methods
to analyse and measure the output
of scientific publications. Within
bibliometrics, scientometrics is
used to measure scientific activity
based on scientific papers.
Outcome
Reveals data that lead to a greater
understanding of the impact of a
particular scientific discipline on
Malaysian science, technology,
engineering and medicine (STEM)
and position Malaysia’s output
in the field against that of the
world and leading countries. This
research will be an important
source of information that will help
to address performance questions
in the context of STEM activities
in Malaysia.
Possible High Impact Journals
for Publications
Scientometrics; Journal of
Informetrics Journal of the
American Society of Information
Science & Technology (JASIST)
Collaborators
Malaysian Citation Centre,
Ministry of Higher Education (Prof
Dr Zainab Awang Ngah)
Statistical Cybermetrics
Research Group University of
Wolverhampton (Prof Dr Mike
Thelwall, Dr Jonathan Levitt, Ms.
Fereshteh Didegah)
Kharazmi University, Iran (Dr
Hamid R.Jamali)
Faculty of Computer Science &
Information Technology, University
of Malaya (Dr Ram Gopal Raj, Dr
Kiran Kaur; Dr Muhammadamin
Erfanmanesh)
High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/FCSIT/12
Title: Implementation of Secure Framework for
Electronic Medical Record (EMRs)
Principal Investigator: Assoc. Prof. Dr. Miss Laiha Mat Kiah
Department: Department of Computer System and Technology,
Summary of Research Proposal
The advancement of Information Technology has witnessed the automation
and migration of many management systems. No exception is the
management of Medical Records. For accessibility and availability reasons,
these records are to be kept in digital format, i.e. referred to as Electronic
Medical Records (EMRs). Since EMRs may be accessed and transmitted in
different ways, it is very important to ensure that these records are kept and
managed securely.
In the development of telemedicine applications, protection of patients’
privacy and medical rec-ords is essential, and under no circumstances
should this information be disclosed to a third party. One particular aspect in
secure management of EMRs is secure transmission and ex-change of these
records. If EMRs are transmitted, the transfer should be conducted in a strict
and secure manner. This research seeks to develop secure techniques and
solutions to address this issue.
Objectives
Methodology
EMR security is one of the most
challenging tasks in this mission.
EMRs are transferred and
stored in different platforms and
networks. In this research, we aim
to develop secure solutions for
EMRs over different platforms and
networks.
We will conduct the research
in three phases. Phase 1 Analyzing the existing EMR
security transmission system
includes the identification of
security parameters for secure
management of EMRs. Phase
2 - Prototype Development will
involve the implementation of
proposed secure framework.
Phase 3 - Testing and Evaluation
will involve the implementation of
proposed solu-tion on different
platforms and networks.
Outcome
1.
Better understanding and
awareness on securing
EMRs.
2.
Secure implementation and
management of EMRs.
Possible High Impact Journals
for Publications
1.
International Journal of
Medical Informatics
2.
Journal Medical Care.
3.
Journal of the American
Medical Informatics
Association.
4.
Journal of Health Services
Research.
Collaborators
Po Lung Yu, Institute of
Information Management, College
of Management, National Chiao
Tung University, Hsin Chu, 30010,
Taiwan; and School of Business,
University of Kansas.
Keith M. Martin, Information
Security Group, Royal Holloway,
University of London.
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/FCSIT/13
Title: An Approach using New Information Extraction
based Traceability and Adaptive Clustering Techniques
to Trace and Cluster Requirements for Software
Maintenance and Quality Assessment.
Principal Investigator: Professor Dr. Lee Sai Peck.
Faculty: Faculty of Computer Science and Information Technology
Summary of Research Proposal
This research aims to develop an approach using new IE-based traceability
and software clus-tering techniques for requirements traceability and
clustering. The IE-based traceability tech-nique will extract and trace
requirements including non-functional requirements from and in software
artifacts of projects automatically, whereas the clustering technique that is
capable of scaling dynamically with the project size will produce a high-level
abstraction of software de-sign from these artifacts. An automated solution
based on the approach will be produced.
Objectives
Methodology
Outcome
1.
To determine a suitable
approach using IE-based
traceability and software
clustering techniques for
requirements traceability and
clustering.
2.
To propose a new IE-based
traceability technique to
extract and trace nonfunctional re-quirements
from/in the software artifacts
of projects automatically.
The research begins with an
in-depth study of literature
on requirements traceability
and cluster-ing. Due to the
textual nature of majority of the
information sources in the field
of requirements traceability, we
decide to use IE techniques, i.e.
a branch of Text Mining (TM)
method that ex-tracts information
from textual format of documents
to trace requirements. A study
on the fun-damental concepts
of software remodularization in
reverse engineering will also be
conducted. In searching for the
optimum solution, a new adaptive
software clustering technique will
be in-troduced in this research.
The idea of adaptive clustering
technique is meant to cater for
large software projects while
minimizing the time to execute the
proposed solution.
An approach supported by a new
IE-based traceability technique
to trace requirements and a new
adaptive clustering technique
to cluster requirements for
software maintenance and quality
assessment.
3.
To propose a new adaptive
clustering technique that
is capable of producing a
high-level abstraction of
software design and scales
dynamically with the project
size.
4.
To produce an automated
solution based on the
approach that uses the
proposed tech-niques.
5.
To assess, evaluate and
benchmark the proposed
solutions.
Possible High Impact Journals
for Publications
1.
IEEE Software
2.
Information and Software
Technology
3.
ACM Transactions on
Software Engineering and
Methodology
4.
Computer
5.
IEEE Transactions on
Software Engineering
Collaborators
Professor Colette Rolland,
Université Paris 1 PanthéonSorbonne
High Impact Research Annual Report 2012
RESEARCH PROPOSAL
(HIR-MoHE 4 Years)
Chancellory
Project No: UM.C/625/1/HIR/MOHE/CHAN/11
Title: Molecular Phylogenetics and Systematics
Principal Investigator: Prof Dr Yong Hoi Sen
Department: Faculty of Science
Summary of Research Proposal
The study will focus on organisms of agriculture and public health
importance and species with unique/specific features (e.g. parasites,
generalists and specialists). It aims to provide answers to the systematic
status of species complexes (occurrence of cryptic/sibling species),
phylogenetic relationships, phylogeography, phylogenomics, and genetic
markers for diseases. The main approach will be DNA sequencing and
genome analysis.
Objectives
Methodology
1.
DNA sequences of selected
genes will be analyzed to
determine phylogenetic
relationships, genetic diversity
and systematics (occurrence of
cryptic/sibling species, taxonomic
identification, etc). For certain
groups, organisms from various
geographical areas (e.g. Wallacea,
Indochina) will be used also for
biogeography/phylogeography
analysis. A draft Genome will be
generated for flagship organism
using sequence-by-synthesis
approach (PacBio and Illumina
sequencers).
2.
3.
Phylogenetics,
phylogeography and
systematics of parasites of
public health im-portance
– e.g. Angiostrongylus
spp. and Anisakis spp.
Focus will be on molecular
dif-ferentiation using
DNA sequences and
immunodiagnosis. The
genome of Angiostrongy-lus
spp will be attempted.
Phylogenetics, systematics,
phylogeography and
biodiversity of arthropods –
or-ganisms include tephritid
fruit flies (of agiculture
importance), odonates
(beneficial in-sects), stingless
bees (beneficial insects),
spiders (beneficial animals)
and other groups with unique
life history. Phylogenomics of
selected animals with unique
features will be studied.
Phylogenetics,
phylogeography and
systematics of vertebrates –
focus will be on amphibians,
reptiles and mammals.
4.
Genotyping of diseases –
e.g. Parkinson’s Disease,
angiostrongyliasis and
anisakiasis.
5.
Phylogenomics – flagship
organisms with unique
features.
Possible High Impact Journals
for Publications
A. No. Of Tier 1 Publications
Expected 11 in 4 years
B. List of 5 Tier 1 ISI/Web of
Science Journals (PloS ONE,
Emerging Infectious Disease,
Parkinsonism and Related
Disorder, Molecular Biology and
Evolution, BMC Genomics ).
Collaborators
Dr. Lim Phaik Eem (Institute of
Biological Sciences, UM)
Outcome
Dr Praphathip Eamsobhana
(Faculty of Medicine Siriraj
Hospital, Mahidol University,
4 publications have been
published and 2 publications have
been accepted:
Thailand)
Emerging Infectious Disease (ISI
– Q1), Parkinsonism and Related
Disorders (ISI – Q1), Journal of
Science and Technology in the
Tropics (Scopus), The Raffles
Bulletin of Zoology (ISI – Q2),
Biodiversity Pulau Tioman (book).
Professor Masafumi Matsui (Kyoto
University, Japan)
Professor Masayuki Sumida
(Hiroshima University, Japan)
Dr I. Wayan Suana (Mataram
University, Indonesia)
Dr Loh Han Chern (UTAR,
Malaysia)
Professor Lim Shen Yang (Faculty
of Medicine, UM)
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High Impact Research Annual Report 2012
Project No: UM.C/625/1/HIR/MOHE/CHAN/12
Title: Neurosurgery Movement Disorder And Operative
Device Development Research
Principal Investigator: Prof Dr Vickneswaran Mathaneswaran
Department: Faculty of Medicine
Summary of Research Proposal
A.
Transfer primate work conducted in Oxford to UM-Human and rat
olfactory stem cells injected into the striatum reverses Parkinsonian
symptoms in a rat model to be repeated in MPTP treated monkeys.
Functionality of autologous transplantation of olfactory stem cells
overcomes ethical problems of foetal transplants and revolutionizes
treatment of PD and other causes of akinesia.
B.
To develop and expand work on neurosurgical endoscopic devices
and surgical simulation-The team in UM develops novel devices and
training modules utilizing 3D pro-totyping techniques. Success leads to
accurate simulative surgery utilizing models using actual patient data
creating specific models with pathologies for training and testing newly
developed devices.
Objectives
Methodology
Collaborators
Project A-Overall aim to is improve
surgical treatment of akinesia
A.
Assoc. Prof. Dr. Dharmendra
Ganesan
Project B-Develop a variety of
anatomically accurate models
with pathology, assess and verify
accuracy of models developed,
allow testing of a variety of
materials with models having
tissue characteristics, integrate
electronic systems allowing
automated detection and track
training procedures, develop
surgical devices for neurosurgical
neuroendoscopy.
B.
Primate Research In
Neurosurgery- Identify the
association of anatomical,
physiological and radiological
correlations using primate
models and initiation of
stem cell research in basic
sciences and clinical
applications.
Surgical Biomodel Simulators
And Tool DevelopmentCreate similar models with
pa-thology and assess
accuracy and usefulness as
simulation devices.
Associate Professor Kamal Azrin
Abdullah @ Kalai Arasu A/L
Muthusamy
Dr. Hari Chandran
Thambinayagam
Dr. Sia Sheau Fung Dr. N.Vairavan A/L N.V.V.E
Narayanan
Prof Dr Zainal Ariff B Abd Rahman
Outcome
Professor John F Stein
3 publications have been
accepted:
Dr. Nick de Pennington
Journal of Clinical Neuroscience
(ISI- TIER 4),Journal of
Neurological Surgery -Part A
(ISI- TI-ER 4), American Journal of
Rhinology & Allergy (ISI- TIER 1).
Possible High Impact Journals for
Publications
A. No. Of Tier 1 Publications
Expected 10 in the initial 2
years (both projects)
B. List of 5 Tier 1 ISI/Web
of Science Journals
(both projects-Nature
Neuroscience, Lancet,
Cell Research, Movement
disorder,and Journal of
Neurosurgery).
UM HIR PUBLICATION HIGHLIGHTS 2012
150
High Impact Research Annual Report 2012
UM HIR PUBLICATION HIGHLIGHTS 2012
Prof. Rauzah Hashim from the Department of Chemistry has come a long
way since she developed an interest in computational science research.
“Strange as it may seem, prior to 1990, computational science as a subject
was quite unheard of in Malaysia, let alone using it to solve problems”,
said Rauzah. However, this did not deter her from taking on this research
challenge after graduating from the University of Southampton in liquid
crystal modelling, making her a pioneer in the field of computational science
in Malaysia.
PROF. DR. RAUZAH HASHIM
One of the major challenges she faced in the early days was a lack of
general facilities in computing. She set herself the task of rectifying this and
went on to set up the Internet facilities in her department in 1992, allowing
her to be connected to any fast computers in the world and to her fellow
theoretician friends and liquid crystallers worldwide. “The kimia network with
over 70 nodes, which I established was four years ahead of the University
campus wide network”, she proudly claimed.
From 1990 and for the next 10 years, Rauzah conducted many seminars
and workshops to popularize the subject of computational science in
Malaysia. Subsequently many high performance computational centers
reflecting much of her early ideas were established, including the one in
MIMOS set up in 2003. She was a member of the University of Malaya
Campus Network Technical Committee (1996-1998), the MIMOS National
GRID Initiative (2006-2009) as well as a member of the ICS-UNIDO Expert
Group for the Combinatorial Chemistry and Related Sciences (1997-2003).
She won numerous grants locally and abroad. Her expertise in informatics
sciences (modeling, simulation and database) proved useful when in 2002,
she was entrusted to lead one of the MOSTI top-down strategic programs
entitled “Glycolipid Science and Technology”, leading 4 institutions to
research into glycolipids from synthesis, fundamental studies as well as
development of applications for surfactants and nano-materials. This
project developed and synthesized the branched-chain glycoside family
which won many awards and recognition for its potential use in liquid crystal
applications. The accolades include the Gold Medal and Special Award from
Taiwan at the ITEX Geneva 2005 and the 2007 finalist in The Prime Minister
Innovation Awards.
To this day, Rauzah continues to pursue fundamental investigations from
molecular and phenomenological approaches, relating structures to
properties with the aim to understand natural processes and improving new
materials and formulations. Rauzah is the principal investigator of the high
impact research grant (HIR-UM/MOHE) on the Fundamental Science of
Self-Assembly (2011-2016). The focus of this research is on understanding
the fundamental aspects (static, dynamics, theory and simulation) of selfassembly materials including liquid crystals and nanomaterials. She has
established an extensive network of collaborators from renowned institutions
worldwide (University of Southampton, Imperial College, University of
Manchester, Hamburg University, University of Pavia, Kent-State Liquid
Crystal Institute, CSIC Barcelona, Sultan Qaboos University, Muscat and
King Abdul Aziz University, Jedah).
With the motto of “the future is now!”, Rauzah and her collaborators have
contributed actively to high impact publications through the HIR MoHE
funding.
High Impact Research Annual Report 2012
151
152
High Impact Research Annual Report 2012
TIER 1 PUBLICATIONS
No
Year
1
2012
Molecular Dynamics Study of Anhydrous
Bi-layers of Synthetic Glycolipids: Effects
of Chain Branching and Disaccharide
Headgroup
Title
Journal of Physical Chem-istry B
(DOI:10.1021/jp302292s)
Journal
Impact Factor
3.696
2
2012
Fluorescene Probing of the Temperature
–Induced Phase Transition in a Glycolipid
Self-Assembly
Langmuir 28(11): 4989-4995
4.26
3
2012
Physicochemical Characterization of
Natural-like Branched-Chain Glycosides
towards for-mation of hexosomes and
vesicles
Langmuir, 2012, 28 (5), 2395 2403
4.9
4
2012
Preparation and Characterization of Ti
oxide, SnO2 nanoparticles decorated
grapheme
Ceramics International, 38: 42094216, (Q1)
1.68
5
2012
Green synthesis of colloidal silver
nanoparti-cles by sonochemical method
Materials Letters 66: 117-120
2.19
6
2012
Highly Efficient preparation of ZnO
nanorods decorated Reduced Graphene
Oxide Nano-particles
Materials Letters. Accept-ed. (Q1)
2.194
7
2012
Facile preparation of graphene-based
Chitosan Films : Enhanced thermal,
mechanical and antibacterial properties
Journal of Non-Crystalline Solids,
358(3): 525-530
1.537
8
2012
Graphene Oxide and Its Electrochemical
Per-formance
Int. Journal of Electro-chemical Sci, 7
(2012) 4345-4351
2.808
9
2012
Effects of carbon substrates on
biodegradable polymer composition and
stability produced by Delftia tsuruhatensis
Bet002 isolated from palm oil mill effluent.
Polymer Degradation and
Stability (DOI 10.1016/j.
polymdegradstab.2012.05.041)
2.594
10
2012
Biosynthesis and Characterization of
Polyhydroxyalkanoates Copolymers
Produced by Pseudomonas putida Bet001
Isolated from Palm Oil Mill Effluent
PLOS ONE (accepted)
4.092
11
2012
Alkyl triazole glycosides (ATGs)-A new
class of bio-related surfactants
Colloids Surf B Biointerfaces. 2012
Sep 1;97:196-200. Epub 2012 Apr 28.
2.780
12
2011
Ultrasound Assisted Lipase Catalyzed of
poly-6-Hydroxyhexanoate
Ultrasonics Sonochemistry 19: 659667
3.4
13
2011
Characterization of the Head Group and
the Hydrophobic Regions of a Glycolipid
Lyotropic Phase using Fluorescent Probes
Journal of Phys. Chem. C (2011), 115
(40), 19805-19810
4.52
14
2011
Fabrication and Characterization of
Graphene Hydrogel via hydrothermal
approach as a scaffold for preliminary
study of cell growth
Int. Journal of Nanomedicine 6: 18171823
4.9
15
2011
Simple Room Temperature Preparation of
High-Yield large –Area Graphene Oxide
Int. Journal of Nanomedicine 6: 34433448
4.9
16
2011
Spherical Tin Oxide, SnO2 Particles
Fabricat-ed via Facile Hydrothermal
Method for Detec-tion of Mercury (II) Ions
Int. Journal of Electro-chemical Sci, 6
(2011) 4329-4340
2.8
17
2011
Morphological studies of randomized
disper-sion magnetite nanoclusters coated
with silica
Ceramic International 37 : 451-464
1.68
UM HIR SPECIAL FEATURE 2012
154
High Impact Research Annual Report 2012
UM HIR SPECIAL FEATURE 2012
DR. HUANG NAY MING
UM HIR was proud to announce the news that Dr. Huang Nay Ming from Physics Depart-ment has been awarded the
National Young Scientist 2012 by the Ministry of Science, Technology and Innovation for his outstanding research on
graphene and nanomaterials. Earlier this year, Dr. Huang was also awarded the Young Researcher 2012 by Universiti
Malaya. Syabas and well done.
Huang Nay Ming was born in Marudi, Baram, Sarawak in 1978. Both his parents were farmers, working in the farm
throughout the year. As the youngest in a family of eight siblings, he was fortunate to have the opportunity to further
his studies up to the tertiary level. Huang graduated with BSc First Class Hons. in 2002 and was the recipient of the
UKM Book Prize Award.
He continued to pursue his MSc and PhD studies at Universiti Kebangsaan Malaysia. His postgraduate research
focused on nanomaterials synthesis and applications. Upon completion of his PhD in 2009, Huang was employed by
University of Malaya as Senior Lecturer in the Physics Department, Faculty of Science. He is a member of the Low
Dimensional Materials Research Centre since then.
His current research interest is slanted towards the fabrication of graphene and graphene-based nanocomposites.
Huang applied these graphene nanomaterials in the fields of sensors, solar energy conversion and energy storage
applications. Since 2009, his research has been funded by the Ministry of Higher Education, MOHE (ERGS, FRGS,
HIR-MOHE), Ministry of Science, Technology and Innovation of Malaysia, MOSTI (e-Science fund, NND grant) and
the internal grants of University of Malaya such as UMRG, HIR-UM and PPP grants. For HIR-MOHE grant, he is
the co-researcher for two projects entitled “Fundamental of Self-Assembly” (RM 10.8 mil-lions) and “Synthesis and
Applications of Low Dimensional Materials” (RM 8.8 millions).
Recently, his proposal on “Graphene-Inorganic Nanocomposites and Their Applications” has been approved for the
HIR-MOHE 3rd cycle application (RM 2.06 millions), which will enable him to work closely with the top graphene
researcher from The University of Texas in Austin, Prof. Dr. Rodney Ruoff.
In Malaysia, Huang pioneered research graphene which he started in 2009. He has published over 20 graphene papers
in ISI-cited journals since then and is supervising 18 postgraduate students on graphene-related projects (6 PhD
and 12 MSc students). Up till today, Huang has published 54 ISI-cited journal papers with a total citation of 352 and
H-index of 11. In addition, he has filed 4 patents on graphene technology. He is also an active reviewer for more than
15 scientific journals and reviews more than 20 journal articles per year.
“I am highly grateful for the opportunities given to me and the recognition by various parties and will work harder to
achieve greater heights”, Huang said modestly.
High Impact Research Annual Report 2012
PUBLICATIONS (ISI CITED JOURNALS)
2012
1.
Vijay Kumar, S., Huang, N.M., N. Yusoff, Lim,
H.N., 2012. High Performance Magnetically
Separable Graphene/Zinc Oxide Nanocomposite.
Materials Letters. Accepted.
2.
Golsheikh, A.M., Huang, N.M., Lim, H.N.,
Chia, C.H., Harrison, I. and Muhamad, M.R.
2012. One-pot hydrothermal synthesis and
characterization of FeS2 (pyrite)/graphene
nanocomposite. Chemical Engineering Journal
Accepted.
3.
4.
5.
6.
7.
Vijay Kumar, S., Huang, N.M., Lim, H.N.,
Marlinda, A.R., Harrison, I. and Chia, C.H. 2012.
One-step size-controlled synthesis of functional
graphene oxide/silver nanocomposite at room
temperature. Chemical Engineering Journal
Accepted.
Chook, S.W. C.H. Chia, S. Zakaria, M.K. Ayob,
K.L. Chee, N.M. Huang, H.M. Neoh, H.N. Lim, R.
Jamal, R.M.F.R.A. Rahman. 2012. Antibacterial
Performance of Ag Nanoparticles and AgGO
nanocomposites prepared via rapid microwaveassisted synthesis method. Nanoscale Research
Letter. 7: 541.
Fatin, S.O., Lim, H.N., Tan, W.T., Huang, N.M.
2012. Comparison of Photocatalytic Activity and
Cyclic Voltammetry of Zinc Oxide and Titanium
Dioxide Nanoparticles toward Degrada-tion
of Methylene Blue. International Journal of
Electrochemical Sciences. 7:9074-9084.
Zainy, M., Huang, N.M., Vijay Kumar, S. and Lim,
H.N. 2012. Simple and scalable prepara-tion of
reduced graphene oxide-silver nanocomposites
via rapid thermal treatment. Materials Letters 89:
180-183.
P.S. Lim, H. N. Lim, N. M. Huang, C. H. Chia,
I. Harrison. 2012. Room temperature in situ
synthesis of Fe3O4/graphene nanocomposites.
Ceramics International. 38: 6411-6416.
8.
B.Y.S. Chang, N.M. Huang, M.N. An’ amt, M.A.
Rahman, N. Yusoff, M.R. Muhamad, I. Harrison,
C. H. Chia. 2012. Facile hydrothermal preparation
of titanium dioxide decorated re-duced graphene
oxide nanocomposite. International Journal of
Nanomedicine. 2012(7):1-9.
9.
M.A. Ehsan, N.M. Huang, M. Misran, Z.
Arifin, E.R.T. Tiekink, A.P. Safwan, M.
Ebadi, W. J. Basirun and M. Mazhar. 2012.
Photoelectrochemical Characteristics of
Greenockite Thin Films fabricated by AACVD
using a Single-Source Cadmium Precursor,
Chemical Vapor Deposition, 18:191-200.
10. H.N. Lim, R. Nurzulaikha, I. Harrison, S.S. Lim,
W.T. Tan, M.C. Yeo, M.A. Yarmo, N.M. Huang,
Preparation and characterization of tin oxide,
SnO2 nanoparticles decorated graphene,
Ceramics International 38: 4209-4216.
11. F. Y. Ban, H.N. Lim, S. R. Majid, N. M. Huang.
2012. Fabrication of graphene oxide for
supercapacitor application. International Journal
of Electrochemical Science 7:4345-4351.
12. M.A. Rahman, N. Yusoff, M.R. Muhamad, I.
Harrison, M.N. An’ amt, B.Y.S. Chang, N. M.
Huang. 2012. Highly efficient preparation of
ZnO/reduced graphene oxide nanocomposites.
Materials Letters 80:9-12.
13. Lim, H.N., Huang, N.M. and Loo, C.H. 2012.
Facile preparation of graphene-based chitosan
films: Enhanced thermal, mechanical and
antibacterial properties. Journal of NonCrystalline Solids 358: 525-530.
14. M. Darroudi, A. K. Zak, M.R. Muhamad, N.M.
Huang, M. Hakimi. 2012. Green synthesis of
colloidal silver nanoparticles by sonochemical
method. Materials Letters, 66: 117-120.
155
156
High Impact Research Annual Report 2012
PATENTS
1.
A method for synthesizing tin-oxide-graphene
nanocomposite for use as sensor materials,
PI2012 700274, Filing date: 10 May 2012.
3.
Large area graphene/graphene oxide as high
performance nanofiller for polymeric films,
PI2011700112, Filing date: 26 July 2011.
The present invention relates to a method for
synthesizing tin oxide-graphene nanocomposites
and the tin oxide-graphene nanocomposites
synthesized there-of for use as sensor materials.
More particularly, the present invention provides
an innovative method for synthesizing tin oxidegraphenenanocomposites via a facile and mild
microwave hydrothermal process; and tin oxidegraphene nanocomposites synthesized thereof
which are suitable to be used in various gas,
chemical and bio-sensing applications.
The present invention relates to preparation
of natural, synthetic or conducting polymer
composite films, more particularly topreparation
of polymer films such as polyvi-nyl alcohol and
chitosan films, with graphene oxide as filler.
4.
Synthesis of magnetic nanophotocatalyst
(ZnO/Fe3O4) for textile industry wastewater
treatment, PI 20093869. Filing date: 16
September 2009.
The invention describes preparation of ZnO/
Fe3O4 nanophotocatalyst with high perfomance
in industrial wastewater treatment.
2.
Method of making large-area graphene oxide,
PI2011700072, Filing date: 12 May 2011.
The present invention relates generally to
preparation of graphene oxide, more particularly
to preparation of graphene oxide via oxidation of
graphite.
High Impact Research Annual Report 2012
UM HIR SPECIAL FEATURE (2 FEBRUARY 2012)
PROF. DR. HARITH AHMAD
HARITH AHMAD hails from the Department of Physics and heads the Photonics
Research Centre in UM (PRCUM). This Centre, established in 2007, has recently
been identified as a potential High Centre of Excellence (Hi-CoE) by the Ministry of
Higher Education in recognition of the contribution of Harith and his dedicated team
of researchers in photonics research in the country.
PRCUM has been actively engaged in research of optical passive and active
waveguides, namely Erbium-doped optical amplifier and laser, nonlinear wavelength
conversion, fibre Bragg gratings (FBG), and fabrication of planar lightwave
circuits. Facilities in PRCUM include optical fibre test and measurement systems,
optical planar waveguide fabrication, FBG fabrication, micro-fibre workstation,
femtosecond laser oscillators as well as laser direct writing system for polymer
waveguide fabrication.
According to Harith, the introduction of high impact research (HIR) in UM has
opened up oppor-tunities for PRCUM to venture into niche photonics research areas
such as photonics THz gen-eration as well as micro- and nano-fabrication of plasmonics and photonics metamaterials.
This allows PRCUM to develop better human resources and to contribute to further advancement and research in the
field of photonics in Malaysia.
Harith has received many prestigious national and international awards, including the 2010 Merdeka Award for his
pioneering work on solid state lasers in the country. He and his team have published over 300 research papers in
international journals, the most recent are those listed below.
Recent Publications
H. Ahmad, N.A. Awang, A.A. Latif, M.Z. Zulkifli,
Z.A. Ghani and S.W. Harun
Wavelength conversion based on four-wave
mixing in a highly nonlinear fiber in ring
configura-tion. Laser Physics Letters 8, No.
10, 742-746 (2011)
S.W. Harun, R. Akbari, H. Arof and H. Ahmad
Mode-locked bismuth-based erbium-doped
fiber laser with stable and clean femtosecond
pulses output. Laser Physics Letters 8, No. 6,
449-452 (2011)
Chang Hong Pua, Siti Fatimah Norizan,
Sulaiman Wadi Harun and Harith Ahmad
Non-membrane optical microphone based on
longitudinal modes competition.
Sensors and Actuators A, 168, 281-285 (2011)
157
158
High Impact Research Annual Report 2012
UM HIR SPECIAL FEATURE
EMERITUS PROFESSOR DR. YONG HOI SEN
Publication of the book on Biodiversity Pulau Tioman
The publication of this book Biodiversity Pulau Tioman by
Academician Emeritus Professor Dr. Yong Hoi Sen and his team
marks a significant milestone in UM HIR which supported his field
trips under a special allocation from Chancellory to undertake
field trips to many exciting areas in Malaysia, including Pulau
Tioman. Many specimens that he had collected are probably
new to science and will form part of his pursuit on molecular
phylogenetics and systematics.
Prof. Yong is from the Institute of Biological Sciences, Faculty
of Science, UM, and is a Senior Fellow of the Academy of
Sciences Malaysia and a recipient of the Merdeka Award 2010 for
Outstanding Scholastic Achievement. He is also a member of the
UM HIR Committee and a recipient of a grant under Cycle 3 MoHE
to conduct research on Molecular Phylogenetics and Systematics.
Prof. Yong has authored over 300 articles and several books
on the natural heritage of Malaysia. He has served as editor
for several journals, scientific monographs, magazines and the
Animals volume of the Encyclopedia of Malaysia.
About the book
This book provides pictorial glimpses of the biological diversity of Pulau Tioman, off
the coast of Pahang Darul Makmur, Peninsular Malaysia. It covers ecosystem, plant
diversity, animal diver-sity, and conservation. Different life forms and habits as well as
the landscapes are presented to provide an overview of the great diversity of the island.
It should be an interesting read to a variety of people from different walks of life and from
different lands. The colour illustrations will help readers to appreciate the fascinating
biodiversity of the island.
Dato’ Sri Douglas Uggah Embas, Minister of Natural Resources and Environment
Malaysia, in his foreword to this book, congratulated the Department of Wildlife and
National Parks as well as Professor Emeritus Dr. Yong Hoi Sen and the team for initiating
this educational and resourceful publication. He said that the publication of this pictorial
book is in line with the global biodiversity targets to enhance awareness on biodiversity
at all levels of society by 2020 and is an important ingredient to pave the way for
mainstreaming of biodiversity in all sectors as envisaged in the National Policy on Biological Diversity (1998) and also
the Common Vision on Biodiversity.(2009).
HIR congratulates Prof. Yong Hoi Sen for achieving yet another milestone in his rich academic career.
HIR ACTIVITY HIGHLIGHTS
160
High Impact Research Annual Report 2012
HIR ACTIVITY HIGHLIGHTS
Visit Of UM Nobel Fellow, Prof. Barry Marshall
On 13th January 2012, UM Nobel Fellow, Prof. Barry Marshall, paid a courtesy call to Prof. Adeeba Kamarulzaman,
Dean of Medicine, and took the opportunity to review the progress of the MoHE-funded Helicobacter pylori projects
jointly conducted between the University of Western Australia and UM. Barry is also here to attend the Asian Pa-cific
Helicobacter pylori meeting 2012 at the Hotel Shangri-La.
Barry in deep discussion with UM Research Assistants and reviewing the progress of the UM HIR-MoHE
Barry leading the discussion in search of new top-down proposals for the MoHE Cycle 3 fund. Present were
collaborators from France, Japan, Thailand, & USA.
High Impact Research Annual Report 2012
UM HIR NEWS (6TH APRIL 2012)
Update on Cycle 3 MoHE HIR Applications
At the close of Cycle 3 MoHE submission dateline, 116 applications were received by Central HIR (see accompanying
figure). Engineering, Medicine and Science together accounted for 78.4% of the total applications. Of interest were the
11 proposals from the Social Science disci-plines. The budget request for 116 projects was RM219,387,273, leaving
a shortfall of RM54,363,544 since the balance we have was only RM165,023,729. The various HIR commit-tees were
requested to scrutinize proposals in their respective disciplines to ensure that only the most deserving proposals of
high quality will be selected for funding. All proposals will be exter-nally reviewed before submission to the Ministry of
Higher Education in May.
It is gratifying to note that the PIs are targeting high impact journals for publication, including in Nature (9), Science (4),
PNAS (3), PLoS (12), NEJM (1), Lancet (1) and BMJ (1). Hopefully these targets will be achieved by the end of 2015.
No
PTj
Budget (RM)
No of Project
1
Engineering
47,809,479.00
32
2
Medicine
31,159,988.00
30
3
Science
50,080,617.00
29
4
Dentistry
5
Chancellory
6
FCSIT
7
Social Science
8
Built Environment
Total
9,550,540.00
6
63,049,134.00
3 +1
1,624,500.00
4
15,913,015.00
11
200,000.00
1
219,387,273.00
(-RM54,363,544.00)
Balance available for 2013-2015 – RM165,023,729
116
161
162
High Impact Research Annual Report 2012
UM HIR NEWS (20TH APRIL 2012)
Prof. Wong Chi Huey is President of Academia Sinica, Taipei, and was
here from 9-10 April on the invitation of HIR to sign a MoU with UM.
He is currently an Editorial Advisory Board member for the Journal of
American Chemical Society, Angewandte Chemie, Advanced Synthesis
and Catalysis, and Current Opinion in Chemical Biol-ogy. He is also
a member of Board of Scientific Governors of the Scripps Research
Institute, the Steering Committee of the Lilly TB Drug Discov-ery
Initiative, and the Chief Science Advisor of the Ministry of Science,
Taiwan. His research interests are in the areas of bioorganic and synthetic chemistry and biocatalysis, including syn-thesis of complex
carbohydrates, glycoproteins and small-molecule probes for the study
of car-bohydrate-mediated biological recognition, post-translational
glycosylation, and drug discovery. He is the author and co-author
of over 700 publi-cations, 100 patents, and four books (Enzymes in
Synthetic Organic Chemistry, Combinatorial Chemistry in Biology,
Catalysis from A to Z, and Carbohydrate-Based Drug Discovery).
President Wong giving a talk on “From Discovery Research to
Translational Innovation” in the Faculty of Science. This was followed
by visits to several faculties for dialogue sessions on research
collaboration.
Abstract: “From Discovery Research to Translational Innovation”
The talk presented recent advances in carbohydrate chemistry and biology with emphasis on a scientific research path
from discovery research to innovative development to illustrate the im-portant contribution of this field.
Protein glycosylation is the most complex post-translational process; more than 90 percent of human proteins are
predicted to be glycosylated. The significance of glycosylation at the molec-ular level is however not well understood,
and as such the pace for the development of carbo-hydrate-based drug discovery and diagnosis is relatively slow. It
is thus important to develop new tools to study the effect of glycosylation on the structure and function of proteins
and other biologically active molecules. This presentation will focus on the development of new methods for the
synthesis of homogeneous glycoproteins with well defined glycan structure, study of gly-cosylation effect on protein
folding, development of glycan arrays for disease diagnosis and for the high-throughput analysis of protein-glycan
interaction, and design of carbohydrate-based therapeutics and vaccines to tackle the problems of cancer and
infectious diseases.
High Impact Research Annual Report 2012
UM HIR NEWS (24TH APRIL 2012)
UM Breast Cancer Research Team Calls for Standardization of Clinical Breast-Density
Measurement
Professor Kwan-Hoong Ng, a senior medical physics professor at the
Department of Biomedical Imaging, University of Malaya, and Prof. Yip
Cheng Har and Associate Professor Nur Aishah Mohd Taib, from the
Department of Surgery, University of Malaya, have published a timely
article in the Lancet Oncology that will have impact on women’s health
globally. They argue for the standardisation of clinical breast density
measurement based on three dimensional data. This issue has also
caught the attention of the international community.
For a long time Prof. Ng has been leading multi-disciplinary research
on the early detection of breast cancer using imaging techniques, and
in particular improving method to measure accurately the amount of
glandular tissue in the breast, known as breast density. Women with
dense tissue in 75% or more of the breast face a risk of breast cancer that
is four to six times greater than women with little or no dense tissue. In
another word, high breast density generally has a relatively higher breast
cancer risk.
The Mammography Reporting Act of 2011 was introduced to US
Congress during the Breast Cancer Awareness month. This Bill requires
physicians to provide information regarding a pa-tient’s breast density in
every mammography summary following mammographic examination.
Additionally, they are required to provide counsel on the increased risk
faced by those found to have dense breast. The other countries are expected to follow this development with great
in-terest.
Traditionally, the assessment of mammographic breast density is subjective and depends on the training and
experience of the radiologist. Professor Ng echoed that “there is an urgent need to establish and validate an
international standard for clinical breast density measurement that considers the breast volumetrically. Guidelines for
standardised measurement techniques and a quality control protocol should be set up.”
In his research, Professor Ng has been working with breast surgeons and radiologists, together with several of his
international medical physics collaborators. Professor Ng has also called for greater awareness of breast density
among the medical profession and the public that will play an essential role in breast cancer risk management and thus
saving thousands of lives.
The article entitled “Standardisation of clinical breast-density measurement” can be found in the Lancet Oncology 13,
334-336 (April 2012).
163
164
High Impact Research Annual Report 2012
UM HIR NEWS (25TH APRIL 2012)
JOINT PRESS RELEASE BY UNIVERSITI MALAYA AND CANCER RESEARCH INITIA-TIVES
FOUNDATION
Malaysian scientists contribute to a study published in NATURE-Medicine discovering a new function for
breast cancer gene BRCA1
Scientists at the National Cancer Institute (NCI) have uncovered a new function for BRCA1, a gene most commonly
associated with hereditary breast and ovarian cancer. Working on mouse cells in the lab, they discovered that BRCA1
suppresses the expression of another gene that codes for a microRNA called miR-155, which is known to be cancer
causing. These findings, published online Sept. 25, 2011, in Nature Medicine suggest that BRCA1 functions as a tumor
suppressor not only by playing a role in DNA repair, as known previously, but also by silencing a gene that can cause
cancer when over-expressed. When the scientists inactivated miR-155 in tumor cells in mice, it slowed down the
growth of tumors. If the BRCA1-associated tumors are confirmed to be dependent upon miR-155, it may be possible
to treat hereditary cancers by challenging them with agents that can inactivate mir-155.
The scientists also investigated precisely how BRCA1 silences miR-155 in cells. Shyam K. Sharan, Ph.D, head of
the Genetics Cancer Susceptibility Section, Mouse Cancer Genetics Program, NCI-Frederick and Suhwan Chang,
Ph.D., research fellow, found that BRCA1, through its interaction with another protein called histone deacetylase2,
modifies the proteins (known as histones) that wrap around DNA and help maintain its structure. As a result of these
modifications, DNA is prevented from expressing miR-155. If there is a defect in BRCA1, these modifications of DNA
do not occur and miR-155 is over-expressed. Based on a strong correla-tion between BRCA1 mutation and miR155 over-expression in tumors, the scientists also sug-gest that miR-155 could be used as a biomarker for BRCA1deficient human tumors.
(From the National Cancer Institute News Note)
“We are delighted to have had the opportunity to contribute to Dr Sharan’s study.
Since 2003, CARIF and University Malaya have established the Malaysian breast
cancer genetic study and through this study, we have identified genes which cause
some individuals to be more likely to develop breast cancer. The collaboration with
Dr Sharan has enabled us to understand the function of these genes even better,”
says Prof Teo Soo Hwang.
The full article entitled “Tumor Suppressor BRCA1 epigenetically controls oncogenic
miRNA-155” can be found in Nature Medicine (2011) Sep 25;17(10):1275-82. doi:
10.1038/nm.2459. Erratum in: Nat Med. 2011 Nov; 17(11):1521. Nat Med. 2011 Oct;
17(10):2 p following 1282
The complete list of authors is as follows :
Suhwan Chang, Rui-Hong Wang, Keiko Akagi, Kyung-Ae Kim, Betty K. Martin, Luca
Cavallone, kConFab, Diana C. Haines, Mark Basik, Phuong Mai, Elizabeth Poggi,
Claudine Isaacs, Lai M. Looi, Kein S. Mun, Mark H. Greene, Stephen W. Byers, Soo
H. Teo, Chu-Xia Deng and Shyam K. Sharan.
Soo H. Teo is Chief
Executive, Cancer Research
Initiatives Foundation
and Adjunct Professor,
University Malaya Medical
Centre, Kuala Lumpur,
Malaysia.
Lai M. Looi (left) and Kein S. Mun (right) are from the Department of Pathology, University of Malaya Medical
Centre, Kuala Lumpur, Malaysia.
High Impact Research Annual Report 2012
UM HIR NEWS (25 SEPTEMBER 2012)
UM HIR First Year Anniversary of MoHE Funding
UM Vice-Chancellor, Tan Sri Dr. Ghauth Jasmon, kindly officiated the function to
mark the first year anniversary of MoHE Funding for high impact research in UM.
The event was attended by HIR principal investigators and their research teams,
including postdocs and postgraduate students.
Tan Sri VC reminded the audience as to why UM is the only research university
in the country which received this special allocation of RM590 million. He firmly
believes that world university ranking is important in enhancing the global image of
the institution and has pledged to the Cab-inet that UM will try to get within the top
100 QS World University Rankings by 2015. “In the last 2 years, UM has performed
well by jumping 51 positions. Now we need to beat another 56 uni-versities to
reach the 100th position by 2015. If we can achieve that, then I am confident of getting better research funding for UM HIR to enable us to reach the top 50 QS World
University Rankings by 2020” he said.
Tan Sri VC congratulated the HIR Committee for its many achievements in the
last 12 months, including the setting up of the UM HIR Advisory Council, consisting of 3 Nobel Laureates and 2
Distinguished Professors. The 5 Council members are actively engaged in research with UM PIs and have provided
invaluable guidance and support through their respective ivy-league institutions. Tan Sri VC commended the PIs for
making remarkable progress in the quality and quantity of their publications, including several articles in high impact
Tier 1 ISI/WoS journals such as Nature and Lancet. “I have been informed by Prof. Dato’ Dr. Amin Jalaludin, Chairman
of the Pre-HIR Committee, that another 3 papers are under review in Nature Genetics, with many more in the pipeline
in the coming years.” said Tan Sri.
Tan Sri VC went on to inform the audience that the granting of university autonomy recently by the government
comes with it a lot of added responsibilities for him and the University Board. “The government has set KPIs for all
autonomous universities in terms of operating cost. UM will have to raise 20% of its operating cost in 2012, 30% in
2015 and 50% in 2020. All senior academic staff, especially professors, have to find innovative ways to raise funds
to help the university. Don’t leave it all to me or to the Board members,” quipped Tan Sri. He warned that the coming
few years will be extremely challenging for UM. “Not only do we have to get into the top 100 world ranked universities
by 2015, we also now have to find the additonal operating funds to keep pace with the fast development of UM. The
future of UM is not only based on ac-ademic progress but also on business acument of the VC. Nevertheless, I have
faith in the loy-alty and support of UM warga, and together, we can bring UM to greater heights and regain our past
glory!” Tan Sri concluded.
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High Impact Research Annual Report 2012
High Impact Research Annual Report 2012
UM HIR NEWS (7 SEPTEMBER 2012)
The UM HIR Committee is pleased to announce the appointment of Prof. Rofina
Yasmin Othman to be a member of the Central HIR Committee by Tan Sri VC. Yasmin
is attached to the Institute of Biological Sciences, Faculty of Science and Centre for
Research in Biotechnology for Agriculture CEBAR , UMBIO, University of Malaya.
Yasmin completed her MSc at the University of Malaya in 1990. She was awarded a
Chevening scholarship to pursue a Ph.D. in Plant Virology at the John Innes Institute
of Plant Science, U.K. On her return, she joined UM as a lecturer in the Department
of Genetics and Cellular Biology and was appointed as a full Professor in 2005. She
runs an active research group and has published extensively, focusing on utilising
modern biotechnology strategies to tackle fundamental problems in agriculture and
has filed 10 patents and graduated more than 12 PhD and 25 MSc students from her
laboratory.
She is a member of the International Banana Genomics consortium, an associate
Fellow of the IMBN, an associate fellow of the Academy of Sciences Malaysia, was a member of UNIDOs South-South
Biosafety network and is a founding member of the Asian Network for Biosafety Education. She was a member of
the National Genetic Modification Advisory Committee Malaysia and is currently a member of the National Biosafety
Board.
Yasmin was the founding head of the Centre for Research in Biotechnology for Agriculture (www.cebar.um.edu.my)
and Chair of the University’s Biotechnology and Bioproduct Cluster (UMBIO) where she initiated strategies for moving
University R&D into the innovation value chain. She is also chief editor of the Asia Pacific Journal for Molecular Biology
and Biotechnology and is on the editorial board of several other scientific journals.
She recently completed a 3 year secondment to the Ministry of Science Technology and Innovation Malaysia as
Undersecretary of the National Biotechnology Division, (www.biotek.gov.my) which is tasked with the implementation
of national policies and strategies in Biotechnology as well as overseeing six National Institutes and government linked
agencies. She is also a founding trustee of the National Institutes of Biotechnology Malaysia. During her tenure with
MOSTI, Malaysia launched the Bioeconomy Initiative Malaysia designed to spur growth of the biotechnology industry.
Recently she also spearheaded the committee which led to the formation of the National Bioethics Council. She has
sat on the Board of Directors of the Malaysian Agriculture Research and Development Institute MARDI (alternate), the
Board of Governors of the International Centre for Genetic Engineering and Biotechnology, Trieste Italy, was Malaysia’s
representative to the Asean Subcommittee on Biotechnology and is the National Point of Contact (NPC) for UNESCO’s
Microbial Biotechnology Network and SEA-EU-NET FP7(Biotechnology).
Her own research interests are in the application of Biotechnology to value add to agriculture especially in the
utilisation of biotechnology for sustainable use; improvement and conservation of local plant genetic resources as well
as in areas relating to BioPolicies, Bioethics and Biosafety. Her international affiliations currently include programmes
with Fraunhofer IME in Germany, QB3 at UCSF in the USA and The John Innes Institute in the UK.
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High Impact Research Annual Report 2012
UM HIR NEWS (1 OCTOBER 2012)
QMEC Audit of HIR
UM Quality Management and Enhancement Centre (QMEC) conducted an internal audit from 7-25 May 2012 to check
on the management of HIR projects to ensure conformity to requirements of UM and MoHE. The audit focussed on
the plannning, implementation, monitoring and actions for improvement on every stage of research management.
Research projects funded internally by UM and externally by MoHE were randomly sampled from all five faculities and
from projects under Chancellory.
The QMEC audit findings were submitted in a report to Tan Sri VC and the Central HIR Committee following an audit
process which involved careful documentation review, dialogue sessions with the VC, HIR Secreteriat staff and
researchers as well as site visits.
In all, the audit team raises 2 commendations (best practices worthy of praise), 5 affirmations (good practices that
should be maintained/enhanced), and 8 areas for improvement (areas where there are concerns and need improvement).
Commendations
1.
The audit panel commends UM’s management as well as the researchers for rising to the challenge in making this
project a success and giving a new momentum to UM’s research endeavors.
2.
The panel also commends the principal investigators and the research teams for their passion, commitment and
perseverance in carrying out their research activities in a timely manner as stipulated in their proposal.
Affirmations
1.
The panel affirms the various improvement efforts by the HIR secretariat in the management and selection
process, including the setting up of PTjs’ HIR secretariat.
2.
The panel applauds the HIR Secretariat for formulating the requirement and devising a travel report. However,
there should be standardization of travel arrangements and enhanced monitoring
3.
Commended the PTjs and HIR Secretariat for the assurance of space for research. A space audit should be
conducted for a fairer distribution and space provided for equipment purchased.
4.
All information disseminated through e-mails must be concurrently up-dated on the web-page. All
communications done via e-mails must be kept as records.
Recommendations
1.
HIR should set specific criteria for assessors and formulate a
guideline for appointment
2.
Records of application, approval and award of projects should be
cleaned-up and up-dated. All documentation should be verified
and signed by concerned parties.
3.
To re-look into the procedures/guidelines of appointing RAs and
other support staff/assistants, spelling out clearly their Terms of
reference.
4.
PIs should up-date their research group members/collaborators
and inactive members be removed.
5.
A system similar to e-finance be set up for finance monitoring
6.
There should be a realignment of management so as to create a
link between Central HIR Secretariat and PTj Secretariats.
7.
To review the Progress Review Form and improve it to ensure
holistic monitoring of KPIs
8.
To establish a database/system for monitoring of KPI achievement
and an early warning system for non-performers
Conclusion
Although this internal audit by QMEC was carried out on a
sampling process, it was still useful to HIR to receive its various
recommendations. QMEC, in its conclusion, encouraged the HIR
Secretariat to take a holistic approach in their continual improvement actions for all projects under HIR. Overall, the
panel views that there exist some form of system in the planning, execution, monitoring and improving of HIR projects,
but recommends that those system to be maintained and some enhanced.
Acknowledgements
The UM HIR Steering Committee under the chairmanship of Tan Sri VC would like to acknowledge the work of the
QMEC Auditing Team led by Prof. Dr. Fauza Ab. Ghaffar, Director of QMEC. The audit report will be further studied by
the Committee in detail and the recommendations to improve the performance of HIR will be implemented.
High Impact Research Annual Report 2012
UM HIR NEWS (2 NOVEMBER 2012)
Professor Paul Williams, Head of the School of Molecular Medicine, University of
Nottingham, United Kingdom, paid a 2-day visit to Dr. Chan Kok Gan, to review and
evaluate the progress of their joint project on Bacterial Quorum Quenching.
Professor Paul Williams is currently Professor of Molecular Microbiology in the
School of Molecular Medical Sciences, Faculty of Medicine & Health Sciences,
University of Nottingham, U.K. Professor Williams’ research interests have primarily
focused on bacterial cell-to-cell communication (‘quorum sensing’). Prof. Williams
is a Thomson ISI highly cited author and has been invited to give plenary talks at
over 60 international symposia worldwide.
He has authored >280 experimental papers, invited reviews and book chapters, 10
patents filed, designated as ISI Highlycited.com Researcher (Microbiology) 2005
with H-index >68. His research group funding has >£25 million. He has published
in numerous premier Tier 1 ISI-indexed journals: Science, Nature Medicine, Nature Protocols, Nature Biotech, Nature
Genetics, PNAS, EMBO J, The Lancet Infectious Diseases, just to name a few.
For his quorum sensing work Professor Williams was awarded the Royal Pharmaceutical Society’s Conference Science
Medal (1992), the Pfizer Prize (1994), Society of General Microbiology Colworth Prize Lecture (2007) and his video film
entitled “Investigating bacterial communication” which was awarded the silver medal at the 1999 Prix Leonardo Film
Festival.
Prof. Williams has served on the editorial boards of Environmental Microbiology, Journal of Bacteriology Microbiology,
FEMS Microbiology Letters, Biofilms, International Journal of Medical Microbiology and Molecular Microbiology
(advisory board). He has also been a member of the Biotechnology and Biological Sciences Research Council U.K.
(Plants and Microbes Committee), the Medical Research Council U.K. Advisory Board, the Medical Research Council
U.K. College of Experts, the Infection Group of the Society for General Microbiology and was a parent governor at
Mornington Primary School, Nottingham U.K.
During Prof. William’s visit, he gave a lecture entitled “Quorum Sensing and Pseudomonas - a tale of regulatory
networks, multifunctional signal molecules and antibacterial targets”. In this lecture, Prof. Williams elaborated on
the various signalling systems and their regulations in human opportunistic Pseudomonas, and the exploration of its
quorum sensing as novel anti-bacterial targets.
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High Impact Research Annual Report 2012
UM HIR NEWS (7 NOVEMBER 2012)
HIR hosted a talk by a successful UM alumni, Prof. Dr. Kalai Mattee,
who is presently attached to the Department of Molecular and Infectious
Disease, Herbert Wertheim College of Medicine, Florida International
University. The title of her talk was “Genes, Greens, and 65 Roses – The
Pseudomonas aeruginosa Connection”.
Summary
P. aeruginosa is an opportunistic pathogen that causes a variety of
severe and sometimes lethal infections of the respiratory tract, urinary
tract, intestine, eyes, ears, and wounds. It has become a serious threat
to immuno-compromised patients, and has become difficult to treat due
to an increasing resistance (intrinsic and acquired) to multiple antibiotics.
Chronic infection with P. aeruginosa remains the most common cause
of morbidity and mortality among patients with cystic fibrosis (CF),
an inherited genetic disease. Antibiotic therapy, with a mixture of
aminoglycoside and ß-lactam antibiotics, is most often prescribed.
However, the treatment often fails in CF patients due to the emergence of resistant strains. The talk delved briefly into
the molecular mechanisms responsible for resistance and focused on alternative therapies (compounds of botanical
and synthetic origin) to combat the disease.
Professor Dr. Kalai Mathee is the First Founding Faculty Member and Founding Chair of the Department of Molecular
Microbiology and Infectious Diseases, Herbert Wertheim College of Medicine, Florida International University since
2007. Kalai received her BSc (Genetics) and MSc (Microbial Genetics) degrees from the University of Malaya. She went
on to complete her Ph.D. in Molecular Microbiology at the University of Tennessee, Memphis under the tutelage of
Martha M. Howe, a renowned geneticist and former President of American Society for Microbiology. Her fascination
with Pseudomonas aeruginosa and cystic fibrosis (CF) started in 1993 when she joined Dennis Ohman’s lab as a
postdoctoral fellow. In 1999, she joined the Department of Biological Sciences at Florida International University as an
Assistant Professor of Pathogenic Microbiology.
Kalai has established a multi-faceted well-funded (~USD $3 Million) research program focusing on molecular
pathogenesis in the model organism Pseudomonas aeruginosa that is responsible for the high morbidity and
mortality in CF patients. She is well-respected nationally and internationally by researchers in multiple fields, including
Pseudomonas pathogenesis, alternate therapy using botanicals, microbial biofilm development, regulation of
prokaryotic transcription and phage molecular biology. She holds three patents and two licenses. She has published
more than 55 articles and several book chapters in the fields of molecular microbiology, forensic science and
bioinformatics in many high impact journals such as Annual Review of Microbiology (IF:14.3), Nano Letters (IF:13.2),
PNAS (IF: 9.7), Nucleic Acids Research (IF:8.0), and PLoS One (IF:4.0)
In 2011, for her commitment to excellence, Kalai was bestowed the highest honor in FIU, the Inaugural FIU President’s
Council Worlds Ahead Faculty Award, in recognition of her outstanding achievement and a professor who makes an
impact and exceeds expectations.
UNIVERSITY OF MALAYA CENTRAL HIGH IMPACT
RESEARCH (HIR) CORE RESEARCH FACILITIES
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High Impact Research Annual Report 2012
UNIVERSITY OF MALAYA CENTRAL HIGH IMPACT
RESEARCH (HIR) CORE RESEARCH FACILITIES
In 2012 UM Central HIR core research facilities currently located in both ground floor and level 1 of HIR Building
officially opened its doors to offer researchers in UM a wide range of state-of-the art instrumentation and technologies
in various research fields.
Training for the use of the instruments are arranged and only those who are trained will be al-lowed to handle the high
end equipment. The core facilities are available on a pay-per-use or on packages with discounted rate basis to the whole
UM community. For Frequent UM Users, HIR Central offers a range of Platinum, Gold and Silver packages and the fees.
Currently, HIR Central Core Facilities support applications in the areas of Genomics, Cellomics, Proteomics,
Bioinformatics and many others
CFX96 Real-Time PCR System
The CFX96™ Real-time PCR System runs with a 96 well block that can
accommodate 0.2 ml tubes, strips or 96 well plate and can detect 5 different
fluorescent dyes simultaneously.
CFX 96 High-Resolution Melt analysis dedicated software (HRM) has
extended the usefulness of quantitative real-time PCR methodology to
detailed post-PCR sequence analysis, enabling a range of applications, such
as mutation scanning, methylation analysis and SNP genotyping.
Responsible Officer: Dr Ng Ching Ching
QuantStudio 12K Flex Real-Time PCR System
HIR QuantStudio 12K Flex Real Time PCR System is complete with the
following features:
Interchangeable Blocks for Maximum flexibility
96-well Fast Peltier-based Block
384-well Block
Array Card Block
Maximum multiplexing & chemistry options.
Proven fluorescence detection with Enhanced OptiFlex® System
(e.g. white light LED and 21 filter combinations for extremely accurate and
sensitive data collection (excitation 450-760nm; emission 500-720 nm).
Standard propriety dyes that are compatible include SYBR-Green®, VIC®,
FAM®, ROX®, TAMRA® and NED®.
Able to perform a multitiude of applications, in particular Taqman® assays
Gene expression analysis. TaqMan® Gene Expression Assays are the
most comprehensive set of quantitative gene expression assays available,
providing more than 1.3 million primer/probe sets for 23 species, in four
sizes, including your choice of FAM™ or VIC® dye labels. Custom assays
are available for studying the expression of any gene or splice variant in any
organism.
SNP genotyping. The precision of TaqMan® probe–based chemistry makes
SNP genotyping studies easy. Choose from over 4.5 million predesigned
human and mouse TaqMan® SNP Genotyping Assays and 2,700 TaqMan®
High Impact Research Annual Report 2012
DME Genotyping Assays, or Custom TaqMan® SNP Genotyping Assays, in
various sizes.
Copy number analysis. TaqMan® Copy Number Assays are a collection
of over 1.6 million predesigned assays with genome-wide coverage for
human, over 180,000 assays targeting exons for mouse, and Custom Plus
and standard Custom TaqMan® Copy Number Assays when a predesigned
assay is not readily available.
MicroRNA and other noncoding RNA analysis. Innovative TaqMan®
Assays and tools are available for long noncoding RNA quantification,
miRNA profiling, pri-miRNA quantification, small RNA quantification, and
targeted miRNA quantification.
Responsible Officer: Dr Ng Ching Ching
NucliSENS easyMag Total Nucleic Acid Extraction System
An IVD-labelled automated system for total nucleic acid extraction from a
variety of sample types and volumes.
Descriptions:
•
Magnetic extraction based on the Gold standard BOOM technology
(Silica particles)
•
Lysis can be done either on-board or off-board
•
Run Capacity: 1 – 24 samples per run
•
Samples Types: plasma, serum, Sample Type: whole blood, CSF,
sputum, stool, BAL, swabs, dry blood spot, urine etc.
•
Turnaround time: about 40 – 60 minutes for 24 extractions
Responsible Officer: Dr Tee Kok Keng
Luminex 200TM
Luminex 200 is a multiplex bead-based fluoroanalyzer. Powered by xMAP®
Technology, this system enables you to multiplex up to 100 analytes in a
single microplate well, using very small sample volumes. The system delivers
fast and cost-effective bioassay results in many assay formats including
nucleic acid assays, receptor-ligand assays, immunoassays and enzymatic
assays.
HIR Luminex 200 is located in Central Facility 2 and is completed with the
following components:
LX200 Analyzer
XY Platform
Sheath Delivery System]
Luminex IS2.3 Software
Xponent 3.1 Software
Responsible Officer: Dr Tee Kok Keng
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High Impact Research Annual Report 2012
Bioanalyzer 2100
The Agilent 2100 Bioanalyzer is an automated on-chip electrophoresis
system for a wide range of applications:
•
On-chip flow cytometry: automated dual colour flow cytometric assays
with chip-based kits, cell based fluorescence data
•
DNA sizing, DNA Quantification
•
RNA integrity, Quantification and small RNA Sizing
•
Protein sizing, quantification and purity
This instrument is located in Central Facility 2, Level 1 of HIR Building and
is routinely used as a quality control and quantitation device prior to Next
Generation Sequencing.
Responsible Officer: Dr Chan Kok Gan
Tecan Microplate Reader
I.
Tecan Infinite M200 PRO with Quad 4 Monochromator
II.
Filter-based Tecan F200 Pro
Tecan Microplate reader allows user to select any wavelength from UV to
NIR, and to perform absorbance, excitation and emission scans. Users can
access all wavelengths, and change from top to bottom reading, for easy
measurement of multiplexed assays at the touch of a mouse click – no
manual hardware changes are required
Tecan Microplate Reader offers a wide range of biological assays and
measurements including:
DNA/RNA quantification
•
protein quantification
•
reporter gene and gene expression assays
•
cell viability and toxicity assays
•
cell-based assays
•
enzyme assays
•
ELISA
•
immunoassays
•
fluorescence and luminescence applications and many more
Website : http://www.tecan.com
Responsible Officer: Dr Chan Kok Gan
High Impact Research Annual Report 2012
Microflex MALDI-TOF Mass Spectrometry System
The system available in HIR is Bruker Microflex LRF MALDI-TOF Mass
spectrometry System. This system is equipped with a 60 Hz nitrogen laser,
gridless reflectron and microscope ion source and operating under the
integrated user friendly Compass software.
Microflex LRF MALDI-TOF is capable of measuring broad mass range of
small molecule, polymer, protein, and peptide analytes. It is suitable for
microbial identification and classification with library build up.
HIR Microflex MALDI-TOF Mass Spectrometry System is configured with the
following Software:
•
Mass Spectrometry Software Compass 1.3 for Flex
•
MALDI BioTyper 3.1 Software
•
BioTyper Reference Library
•
Bio Tools 3.2 – Software for protein data interpretation
Currently, HIR MALDI-TOF is being used for microorganism identification
Responsible Officer: Dr Loke Mun Fai & Dr Chan Kok Gan
MACSQuant Flow Cytometer
MACSQuant Flow Cytometer enables researchers to gather statistical data
on large numbers of cells and use that information to correlate multiple
parameters within a cell population.
HIR MACSQuant Flowcytometer is equipped with three excitation lasers
(violet 405, Blue 488, and Red 635 nm), two scatters (FSC, SSC) and up to
eight fluorescent channels. The instrument is located in Central Facility 2,
Level 1 HIR Building is able to analyse cells in single tube or from a 96 well
plate.
MACSQuant Flow Cytometry is an essential tool for researchers working in
the field of molecu-lar interactions, pharmacokinetics, cell biology, systems
biology, marine biology, biophysics
Responsible Officer: Dr Ng Ching Ching & Dr Ea Chee Kwee
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High Impact Research Annual Report 2012
HIR CENTRAL EQUIPMENT
Summary of Charges & Responsible Officers for HIR Central Equipment (Set 1)
No
Responsible
Officer
1
Bioanalyzer Expert 2100
2
Capillary Electrophoresis Dr Chan Kok Gan
Dr Chan Kok Gan
3
CFX96 Real Time PCR
4
Present Location
Unit of
Measurement
Charges (RM)
UM
User
Non UM Frequent UM User
User
Central Facility 2, HIR
Per sample
10.00
50.00
400/50 samples
Bilik Khas 3, HIR
Per sample
50.00
100.00
1,500/50 samples
Dr Ng Ching Ching Central Facility 2, HIR
Per hour slot
10.00
50.00
950.00/100 hrs,
1,800.00/200 hrs,
3,000.00/500 hrs
F200 Pro Microplate
Reader
Dr Chan Kok Gan
Central Facility 2, HIR
Per plate of 96
FOC
wells, Quick Read
Overnight Read
50.00
5
GC-MIDI
Dr Chan Kok Gan
Bilik Khas 3, HIR
Per sample
15.00
50.00
700.00/50 samples
6
GC-MS
Dr Loke Mun Fai
Bilik Khas 3, HIR
Per hour slot
50.00
80.00
700.00/20 hrs,
1,000.00/50 hrs
7
Rotary Evaporator
Dr Chan Kok Gan
NPC Lab, IPS
Per hour slot
30.00
100.00
2,500.00/100 hs,
4,000.00/200 hrs
8
LC/MS/MS Triple
Quadrupole Mass
Spectrometer
Dr Chan Kok Gan
Bilik Khas 3, HIR
Per 3-hour slot
300.00 800.00
Per 8 working
hrs slot
500.00 1,500.00 2,200.00/5 x 8
working hrs slot
200.00 500.00
100.00
1,500.00/50 plates
7,500.00/100 hrs,
14,000.00/200 hrs
9
Luminex 200
Dr Tee Kok Keng
Central Facility 2, HIR
Per 3-hour slot
10
M200 Pro Microplate
Reader
Dr Chan Kok Gan
Central Facility 2, HIR
Per plate of 96
FOC
wells, Quick Read
Overnight Read
50.00
1,500.00/50 plates
11
MacQuant Flow
Cytometry
Dr Ng Ching Ching Central Facility 2, HIR
Per 3-hour slot
200.00 500.00
6,000.00/50 slots,
10,000.00/100 slots
12
Optima XPN100
Ultracentrifuge
Dr Ng Ching Ching Bilik Khas 2, HIR
Per hour slot
10.00
50.00
950.00/100 hrs,
1,800.00/200 hrs,
3,000.00/500 hrs
13
Quantstudio 12K Real
Time PCR
Dr Ng Ching Ching Central Facility 2, HIR
Per hour slot
30.00
100.00
2,500.00/100 hr
slot, 4,000.00/200
hr slot
9,000.00/500 hr
slot
14
Qubit 2.0 Fluorometer
Dr Tee Kok Keng
Central Facility 2, HIR
Per sample
10.00
25.00
300.00/50 samples
500.00/100
samples
15
Ultra High Performace
Liquid Chromatograph
(UHPLC)
Dr Chan Kok Gan
Bilik Khas 3, HIR
Per 3-hour slot
15.00
50.00
600.00/50 slot
1,000.00/100 slot
16
Biolog Omnilog GenIII
Combo Plus System
Dr Chan Kok Gan
Central Facility 1, HIR
1 Day Slot
100.00 400.00
17
Comprehensive Bacterial Dr Chan Kok Gan
Bioluminescence
Imaging System
Bilik Khas 2, HIR
3 Hour Slot
FOC
150.00
1 Day Slot
50.00
300.00
Fermenter
Bilik Khas 2, HIR
3 Hour Slot
FOC
100.00
1 Day Slot
FOC
200.00
3 Hour Slot
FOC
100.00
1 Day Slot
FOC
200.00
3 Hour Slot
FOC
100.00
1 Day Slot
FOC
200.00
per 8 sample slot
(minimal)
320.00 800.00
18
Name of Equipment
Dr Chan Kok Gan
19
Vacuum Concentrator
Dr Chan Kok Gan
Makmal NPC
20
Fluorescence
Microscope
Dr Chan Kok Gan
Central Facility 2, HIR
21
easyMag Liquid
Handling System
Dr Tee Kok Keng
Central Facility 2, HIR
1,200.00/10 slots
100.00
800.00/10 Days
Slot
200.00/100 Hour
100.00/10 days
100.00/10 days
100.00/10 days
1824.00/48
samples (5%
Discount)
Updated as of 22 Dec 2012
FINANCIAL STATEMENT
HIR FACULTY
CONTACT PERSON OF HIR SECRETARIAT
PHOTO GALLERY
ENGINEERING
SCIENCE
DENTAL
COMP. SCIE.
CHANCELLORY
SOC. SCIE.
BUILT ENV.
2
3
4
5
6
7
8
TOTAL :
Balance of Cycle 3
Secretariat
(Balanced Revised 68%)
MEDICINE
Faculty
1
No
ENGINEERING
SCIENCE
DENTAL
COMP. SCIE.
CHANCELLORY
SOC. SCIE.
BUILT ENV.
3
4
5
6
7
8
TOTAL :
Balance of Cycle 3
108,368,721
-
-
6,289,250
3,201,200
15,092,351
0
65,108,120
9,317,851
630,077
692,606
1,589,967
4,931,162
1,474,040
99,050,870
5,659,173
2,508,594
13,502,384
8.60
10.02
21.64
10.53
0.00
7.57
7.89
5
53
-
-
2
6
13
0
27
34.20
43.41
17.53
35.88
33.71
31.79
26.97
% SPENT
75
-
-
9
6
8
12
23
17
No. of
projects
*As of 31st December 2012
204,108,638
59,044,810
7,526,710
8,459,868
39,785,793
36,040,211
53,251,246
RM
Balance
No. of projects
108,325,855
45,297,138
1,599,781
4,734,885
20,228,710
16,797,258
19,668,084
Total
Expenditure
% SPENT
13,514,443
2,271,580
294,653
233,379
7,046,900
60,176,958
0
662,634
RM
CAPEX
3,005,298
17,203,760
RM
Balance
94,811,412
43,025,559
1,305,127
4,501,506
13,181,810
13,791,960
RM
18,677,800
RM
OPEX
Expenditure
19,005,450
RM
316,764,010
4,329,517
-
-
104,341,948
9,126,490
13,194,753
60,014,503
52,837,469
72,919,330
Expenditure
64,887,541
36,806,500
300,500
425,000
10,910,735
5,482,771
10,962,035
RM
CAPEX
Total
Allocation
Allocation for Cycle 2
251,876,469
4,329,517
67,535,448
8,825,990
12,769,753
49,103,768
47,354,698
61,957,295
RM
OPEX
Allocation for Cycle 1
Secretariat
(Balanced Revised 68% )
MEDICINE
2
Faculty
140
-
-
10
13
22
13
62
20
No. of
projects
1
No
590,156,460
-
-
125,000,000
27,268,000
28,287,330
79,904,130
200,000,000
129,697,000
RM
Proposed &
Approved
by MOHE
ALLOCATION & EXPENDITURE AS AT 31 DECEMBER FOR HIR-MOHE
FINANCIAL STATEMENT
178
High Impact Research Annual Report 2012
High Impact Research Annual Report 2012
HIR FACULTY
SECRETARIAT HIR FACULTY OF MEDICINE
From left to right
Siti Fatimah Zahra Mohd Anuar
Amirul Asraf Mohd Jurami
Nur Fazlin Mahfodz
Secretariat, High Impact Research Grant,
Office of the Dean, Faculty of Medicine,
University of Malaya, 50603 Kuala Lumpur
[email protected]
SECRETARIAT HIR FACULTY OF ENGINEERING
From left to right
Mariam Ali
Anis Yusnida Zakaria
Mohd Faiz Ibrahim
Norsaidin Mahusin
Muhammad Khlaid Hashim
Secretariat, High Impact Research Grant,
Deputy Dean (Research) Office,
Level 4, Engineering Tower, Faculty of
Engineering
University of Malaya, 50603 Kuala Lumpur
[email protected]
179
180
High Impact Research Annual Report 2012
SECRETARIAT HIR FACULTY OF SCIENCE
Nur Syahrinar Anuar
Secretariat, High Impact Research Grant,
Office of the Dean, Faculty of Science,
University of Malaya, 50603 Kuala Lumpur
fs.um.edu.my
SECRETARIAT HIR FACULTY OF DENTISTRY
From left to right
Norshida Abdul Manan
Mariah Mansor
Nur Syafiqah Abd Malek
Secretariat, High Impact Research Grant,
Research Management Centre(RMC),
Level 6, Postgraduate & Research Building,
Faculty of Dentistry
University of Malaya, 50603 Kuala Lumpur
[email protected]
SECRETARIAT HIR FACULTY OF COMPUTER SCIENCE & INFORMATION TECHNOLOGY
From left to right
Muhamad Afiq Zaini Alamar
[email protected] Noriah Zainal Abidin
Secretariat, High Impact Research Grant,
Office of the Dean, Faculty of Computer Science
& Information Technology,
University of Malaya, 50603 Kuala Lumpur
www.fsktm.um.edu.my
High Impact Research Annual Report 2012
CONTACT PERSON OF HIR SECRETARIAT
VC’s Office
Siti Zawahir Zubir
03-7967 3400
[email protected]
VC’s Office
Azbullah Che Ibrahim
03-7967 3231
[email protected]
VC’s Office
Nur Ain Valerie Cassera Binti Rapoi
03-7967 7763
[email protected]
VC’s Office
Hamizah Husain
03-7967 7791
[email protected]
VC’s Office
Sarina Ramli
03-7967 7790
[email protected]
VC’s Office
Nabilah Ahmad
03-7967 2092
[email protected]
VC’s Office
Alsaddam Suhaimi
03-7967 2092
[email protected]
Bursar
Haliza Harun
03-7967 3205
[email protected]
Assistant Bursar
Norshahidayu Ali
03-7967 3270
[email protected]
Procurement Unit
Puteri Heirzerein Megat Zamry
03-7967 6996
[email protected]
Payment Unit
Dr. Noor Hashim Taib
03-7967 3403
[email protected]
Faculty of Medicine
Siti Fatimah Zahra Mohd Anuar
03-7967 7515
[email protected]
Faculty of Medicine
Amirul Asraf Mohd Jurami
03-7967 7515
[email protected]
Faculty of Medicine
Nur Fazlin Mahfodz
03-7967 7515
[email protected]
Faculty of Medicine
Siti Falika Ahmad
03-7967 7515
[email protected]
Faculty of Engineering
Norsaidin Mahusin
03-7967 7684
[email protected]
Faculty of Engineering
Muhammad Khlaid Hashim
03-7967 7684
[email protected]
Faculty of Engineering
Mohd Faiz Ibrahim
03-7967 7684
[email protected]
Faculty of Engineering
Rosnani Jaafar
03-7967 7684
[email protected]
Faculty of Engineering
Anis Yusnida Zakaria
03-7967 7684
[email protected]
Faculty of Dentistry
Intan Suhana Hamid
03-7967 6454
[email protected]
Faculty of Dentistry
Norshida Abdul Manan
03-7967 6454
[email protected]
Faculty of Dentistry
Mariah Mansor
03-7967 6454
[email protected]
Faculty of Science
Nur Syahrinar Anuar
03-7967 6758
[email protected]
Faculty of Science
Noor Azlin Che Din
03- 7967 4024 [email protected]
Faculty of Computer Science &
Information Technology
Muhamad Afiq Zaini Alamar
03-7967 6382
[email protected]
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High Impact Research Annual Report 2012
Design and Printed by
University of Malaya Press
50603 Kuala Lumpur