BiomaTiCS

BiomaTiCS
Biomaterials, Tissues and Cells in Science
What is - BiomaTiCS ?
What are the aims of - BiomaTiCS ?
• Advancements in material design and surgical techniques
• BiomaTiCS is an interdisciplinary network of materials scientists and medical
researchers at the Johannes Gutenberg University Medical Center Mainz
• Research focus is the understanding and modulating of complex interactions
between biological systems and artificial as well as biogenic materials
• To focus on medical device-related clinical problems like inflammation, rejection of implants, foreign body
granulomas, excessive scar formation, lack of tissue adhesion, material degradation, infection and toxicity
• To offer an excellent platform for an exchange of information among competent specialists to combine all
their knowledge necessary to tackle these problems
Members and Projects
Prof. Brieger, Department
of Otolaryngology
Prof. Al-Nawas, Department
of Maxillofacial Surgery
Prof. Schreiber, Department of
Diagnostic and Interventional
Radiology
Prof. Jansen, Department of Hygiene and
Environmental Medicine
Prof. Brenner, Department of Urology
Genotoxicity of ZnO-nanoparticles.
The lightened signals show DNA double
strand breaks as result of ZnOnanoparticle exposition. (Prof. Brieger,
Department of Otolaryngology)
Dr. Martin Heller,
Department of Otolaryngology
Dr. Dr. Peer Kämmerer,
Department of Maxillofacial Surgery
A)
Dr. Karbach, Department
of Maxillofacial Surgery
Dr. Dr. Dr. Ziebart, Department
of Maxillofacial Surgery
Tissue-Engineered pre-vascularized
buccal mucosa equivalent.
Lumen of capillary-like structures and
capillary-like structures within the tissue are
equivalent. (Prof. Brenner, Urology, Dr. Unger,
Institute of Pathology)
Fibroblasts Adhesion on titanium. Focal
adhesion complex and cytoskeleton stained
with Hoechst (blue), Zyxin or Vinculin (red)
and Phalloidin (green). (Dr. Kuhn and Dr.
Ritz, Trauma Surgery)
B)
PD Dr. Dr. Koch, Department
of Maxillofacial Surgery
Dr. Unger, Institute of Pathology
PD Dr. Hofmann, Center for
Orthopaedic and Trauma
Surgery
Dr. Kuhn, Center for
Orthopaedic and Trauma
Surgery
VEGF-modified titanium implants.
The dark blue staining shows an increased new bone
formation in vivo at the interface of the modified implant
in B) compared to the untreated sample in A).
(Dr. Heller, Department of Otolaryngology,
Dr. Dr. Kämmerer, Department of Maxillofacial Surgery)
Surface decoration on -tri-calcium phosphate
-TCP) with nanoparticles for modification.
A) -TCP control, B) -TCP with adsorbed
phosphonated polystyrene nanoparticles enable the
encapsulation of growth factors and other modifying
agents to control growth and differentiation of
osteoblasts on biomaterials.
(PD Dr. Mailänder, Prof. Landfester, University Medical
Center and MPIP Mainz)
B)
µCT of a mouse head with critical bone
defects after 6 weeks.
A) Almost closed bone defects by injecting a
collagen gel combined with a co-culture of
osteoblasts and endothelial cells compared to
the control where only collagen gel was used
(B). (PD Dr. Hofman and Dr. Ritz, Center for
Orthopaedic and Trauma Surgery)
B)
A)
A)
Dr. Kohnen, Department of Hygiene
and Environmental Medicine
Scheme of the improvement of osteogenesis
by injecting human multipotent stromal cells
(hMSC).
After fracture (A) hMSC embedded into alginate are
proposed to be injected into the fracture zone (B) in
order to accelerate the velocity of bone formation.
(Prof. Müller, Prof. Schröder, Prof. Wang, Institute of
Physiological Chemistry and University Medical
Center)
Dr. Ritz, Center for
Orthopaedic and Trauma
Surgery
Dr. Nusselt, Center for
Orthopaedic and Trauma
Surgery
Prof. Müller, Department of
Physiological Chemistry
PD Dr. Brochhausen-Delius,
Institute of Pathology
Prof. Wang, German-Chinese Joint
Center on Bioinspired Materials,
University Medical Center
PD Dr. Mailänder, Hematology,
Oncology and Pulmonology
Dr. Gabriel, Department of
Cardiothoracic and Vascular
Surgery
Prof. Schröder, Department of
Physiological Chemistry
National and International Cooperation Partners
• Dr. Lars Choritz (Clinic for Ophthalmology, Otto von Guericke University,
Magdeburg)
• Dr. Renate Förch (Frauenhofer ICT-Institute for Microtechnology, Mainz)
• Dr. Dr. Sharam Ghanaati (Clinic for Maxillofacial and Plastic Surgery,
Johann Wolfgang Goethe University, Frankfurt)
• Dr. Sebastién Hagmann (Department for Orthopaedics, Trauma Surgery
and Paraplegiology, Heidelberg University Hospital)
• Prof. Dr. Anita Ignatius (Institute of Orthopaedic Research and
Biomechanics, University of Ulm)
• Prof. Dr. Ulrich Jonas (Macromolecular Chemistry, University of Siegen)
• Dr. Kaloian Koynow (Max Planck Institute for Polymer Research,
Johannes Gutenberg University, Mainz)
• Prof. Dr. Katharina Landfester (Max Planck Institute for Polymer
Research, Johannes Gutenberg University, Mainz)
• Prof. Dr. Peter Langguth (SAMT, Johannes Gutenberg University, Mainz)
• Prof. Dr. G. Ulrich Nienhaus (Institute for Applied Physics, Karlsruhe
Institute of Technology)
• Dr. Ralf Sanzenbacher (Paul-Ehrlich-Institut, Langen)
• Prof. Dr. Hubert Schrezenmeier (Institute for Clinical Transfusion
Medicine and Immunogenetics, Ulm)
• Prof. Dr Wolfgang Tremel (Department of Chemistry, Johannes
Gutenberg University, Mainz)
• Prof. Dr. Michael Veith (Department of Molecular Biology, Westphalian
University Recklinghausen)
• Dr. Rolf Zehbe (Institute for Materials Sciences and Technologies,
Department of Materials Engineering, Technical University, Berlin)
• Prof. Dr. Rudolf Zentel (SAMT, Johannes Gutenberg University, Mainz)
www.biomatics-mainz.de
• Abdulmonem Alshihri DDS (Department of Restorative and Biomaterial
Science, Harvard School of Dental Medicine, Boston, MA, USA)
• Vinay V. Kumar (Oral and Maxillofacial Surgeon, M. R. Ambedkar Dental
College Bangalore, India)
• Yong-Dae Kwon DMD, MSD, PhD (Associate Professor, Dept. Of Oral and
Maxillofacial Surgery, Kyung Hee University School of Dentistry, Seoul,
Korea)
• Dr. Victor Palarie (State University of Medicine and Pharmaceutics
„Nicolae Testemitanu“ Laboratory of Tissue Engineering and Cell Culture,
Chisinau, Moldova)
• Myron Spector PhD (Professor of Orthopedic Surgery, Harvard Medical
School, Boston, MA, USA)
• Derek M. Steinbacher DMD, MD (Assistant Professor of Surgery and
Pediatrics, Yale School of Medicine, USA)