Spring 2008 - Buyers Guide - American Academy of Anti

Transcription

NEW!
Physician Prescribing
Handbooks for
Bio-Identical
Hormone
Replacement
The Hormone
Handbook
by Thierry Hertoghe, MD
UNIVERSITY
COMPOUNDING
PHARMACY
Eat Right
by Kathleen Becker, MA, RN &
Coreen Reinhart, Certified Nutritionist,
With Foreword by Ron Rothenberg, MD
Younger You
by Eric R. Braverman, MD
Natural Hormone Replacement
by Jonathon V. Wright, MD
and John Morgenthaler
Demystifying Weight Loss
by Pamela W. Smith, MD, MPH
HRT:The Answers
Vitamins: Hype or Hope?
Keeping aBreast,
Ways to STOP Breast Cancer
by Khalid Mahmud, MD, FACP
The Cellulite Cure
by Lionel Bissoon, MD
Maximize Your Vitality & Potency
by Jonathon V. Wright, MD
and Lane Lenard, Ph.D
Forever Ageless:
Advanced Edition
by Ron Rothenberg, MD, FACEP
The Greatest Lectures on
Hormone Therapies
in Audio CD’s
The Clinical
Application of
Interventional
Endocrinology
The Greatest Lectures on
Hormone Therapies in Audio CD’s
by Thierry Hertoghe, MD
by Mark L. Gordon, MD
Thierry
Hertoghe, MD
Ron Rothenberg, Mark
MD, FACEP
Gordon, MD
Eric
Braverman, MD
Jonathan
Wright, MD
Pamela
Smith, MD
To Purchase CALL TODAY 800-985-8065 or VISIT www.ucprx.com
ment
D
e?
PH
tency
D
m
Buyers Guide
DIRECTORY
◗ Gut Detoxification
6
◗ Bio-identical Hormone Restoration in Women 16
◗ Targeting Cancer’s Sweet Spot
◗ Product Announcements
38
11
Vendors by Category
◗
◗
◗
◗
◗
◗
◗
◗
◗
◗
◗
◗
◗
◗
◗
◗
◗
◗
◗
◗
◗
◗
Aesthetic Medical Treatments
22
Alternative Therapies
22
Associations / Education
24
Compounding Pharmacies
24
Computer / EMR
25
Cosmeceuticals
25
Dental / Dermatology
25
Diagnostic Service / Laboratories
25
Hair Rejuvenation
26
Holistic Medicines
28
Hyperbaric / Oxygen Therapies
28
Insurance / Finance /
Practice Management / Marketing
28
Med Spa / Equipment
29
Medical Equipment / Supplies
30
Medical Publications / Directories
32
Mesotherapy / Hormone Therapies
32
Miscellaneous
32
Nutraceuticals
33
Pharmaceutical
36
Sports / Fitness / Physical Therapies
36
Stem Cell Therapies
37
Weight Management
37
WORLD COUNCIL
FOR CLINICAL
ACCREDITATION
(WCCA)
Strategically Position Your
Anti-Aging Clinic or Medical
Spa as An A4M/WCCA Accredited
Facility of Excellence*
Benefits of A4M/WCCA Facility
Accreditation:
s
Prevail amongst generic antiaging clinics and spas with distinguished status as a professionally accredited clinical facility
s
Gain a marketing edge against
your competition through enhanced
positioning at the Online Clinic
Locator at The World Health Network, www.worldhealth.net, the
Internet’s leading anti-aging portal
s
Receive direct patient referrals from the Patient Recruitment
and Education Program (PREP),
an initiative affiliated with the
A4M’s LEXCORE Research Study
SET YOUR ANTI-AGING CLINIC OR MEDICAL SPA
APART FROM THE COMPETITION
L
The A4M/WCCA
Anti-Aging
Clinic /Medical Spa
Accreditation
Program
Enroll your facility in the A4M/
WCCA Anti-Aging Clinic / Medical
Spa Accreditation Program
Accreditation of anti-aging medical clinics and
medical spas serves two primary, fundamental purposes: to assure the quality of the institution and its clinical program, and to assist in
the ongoing improvement of the institution
or program. The A4M/WCCA Anti-Aging Clinic
/ Medical Spa Accreditation Program features
Standards of Excellence that:
r
r
r
r
&NQIBTJ[FZPVSGBDJMJUJFTIJHIMFWFMPG
TFSWJDFBOETBGFUZ
4IPXDBTFBCSPBESBOHFPGBEWBODFE
EJBHOPTUJDTBOEUIFSBQFVUJDTBWBJMBCMFBU ZPVSDMJOJDPSNFEJTQB
&ODPVSBHFQBUJFOUFEVDBUJPOFNQPXFSNFOU
%FNPOTUSBUFZPVSGBDJMJUZTDPNQMJBODFXJUI
UIFIJHIFTUHPWFSOJOHPQFSBUJPOBMTUBOEBSET
of Professional excellence
r &OKPZUIFFOIBODFEWJTJCJMUZBOEQBUJFOU
WPMVNFIFJSUP".*/&5SFGFSBMT
FOR MORE INFORMATION VISIT:
WWW.WORLDHEALTH.NET/ACCREDITATION
Email: [email protected]
Telephone: 773-528-4333
* Facilities accredited by the A4M/WCCA Anti-Aging Clinic / Medical Spa Accreditation Program must follow codes of professional and ethical conduct set forth by the A4M in display and/or use of the A4M Seal and/or Certificate of Accreditation in marketing, advertising, and promotion. See specifics of terms, details, conditions, and disclaimers at www.worldhealth.net/accreditation
Gut Detoxification
By Stephen Holt, MD, LLD(Hon.), ChB, PhD, DNM, FRCP (C), MRCP (UK), FACP, FACG, FACN, FACAM, OSJ,
Distinguished Professor of Medicine, NYCPM, Harlem, N.Y., Scientific Advisor to Natural Clinician LLC, N.J.
The Aging Gut
The aging gastrointestinal tract may
often lose its harmony. Each region
of the gut changes with aging. Such
changes include poor peristaltic function, variable reduction in gastrointestinal secretions and overall decrease in
the efficiency of the complex functions of digestion and absorption. The
elderly colon is often stubborn and
the residence time of fecal contents
increases in the colon, with a tendency for a delay in overall gut transit
time. Reductions in the efficiency of
digestive processes contribute to poor
nutritional status in the elderly; and
the important function of the gut as an
organ of detoxification is often compromised. It is time to reappraise the
importance of gut detoxification in the
promotion of longevity.
Putrefying stool in the colon creates
colorful biochemistry. Volatile compounds generated in the colon (gases
and organic acids) can have good or
bad effects on the body. The colon is
not merely a boring conduit or receptacle for stool. It is a dynamic organ that
handles fluids and partially digested
dietary intake in a regulated way. The
large bowel has a very active lining and
is capable of absorbing many substances, including nutrients and toxins.
The healthy, functioning colon does
not need to be washed out, cleansed or
purged. However, the unhealthy or unbalanced colon often requires this kind
of attention, at least on an intermittent
basis. Intermittent or varying degrees of
colonic malfunction are almost universal at all ages.
The Digesta
The notion that the contents of the gut
play a major role in health or well-being
is not a modern concept. These gut contents are best referred to as the “digesta.”
6 ❘
ANTI-AGING MEDICAL NEWS
The digesta are formed as a consequence of inextricable linkage of diet
and gut function. The digesta is an
ever-changing component of harmonious digestive function and it is the sum
total of the contents of the gastrointestinal tract. The composition of
colonic contents is particularly relevant
to health in several contexts. These
contents are created by ingested food
or drink and modified by additions to
or deletions from the gut (digestive
enzymes, mucus, gases, bile, etc.). All of
these components are modified by the
gut microflora (bacteria, yeasts, molds,
protozoa, parasites, etc.). The average colon contains many wanted and
unwanted guests.
The gut contents form a very active biological soup (or slurry) that
solidifies during its passage through the
colon. This slurry is exposed to a large
surface area of the gut and, in turn,
a large surface area of the body. The
chemical status of the body is usually
defined in context of blood and tissue
contents, without due consideration of
the role that the digesta plays in determining this chemical status. The notion
that the contents of the gut “communicate” with the body has scientific support. The guts are clever organs with
their own brain and limited cognition.
There are a large number of chemicals or metabolic products present or
produced in the digesta, including food
additives, nutrients, organochemicals,
end products of bacterial metabolism,
oxidation products of food, ingested
chemicals or bile, and free radicals produced from bacterial metabolism – to
name a few! In the presence of gut disease, different chemicals or bioactive
end products are produced. Such end
products include, but are not limited
to, reactive nitrogen species and modified proteins that can act as potential
allergens.
The oxidation status of the digesta
may have a profound effect on body
functions. The antioxidant status of
the digesta is largely determined by
food eaten, but it is modified by the
complex ecology of the gut. Antioxidant status of the digesta is particularly
important in the development of intestinal colon cancer or bowel inflammation. Much digestive disease is caused
by free-radical damage (e.g., peptic
ulcer and inflammatory bowel disease).
The function of the digesta has been
often ignored for its potential role in
functional gut disorders, including irritable bowel syndrome or structural gut
problems such as “leaky gut syndrome.”
Antioxidants such as vitamin E or its
analogues (especially gamma-tocopherol) and phytochemicals (especially
isoflavones) may be important in disease prevention and treatment. Many
phytochemicals or phytonutrients and
their end products in the gut may be
absorbed both through the small intestines and the colon into the systemic
circulation; and they often exert direct
effects on the colon. These proposals
are contrary to popular belief among
conventional medicine practitioners
or are dismissed as irrelevant in many
contexts.
The Colon as a Source of Toxins
Allopathic medicine has discounted
the role of the bowel and its inhabitants as a source of toxins for the body.
For many centuries, physicians or
healers believed in the phenomenon of
intestinal autointoxication. This belief
was challenged in the early part of the
20th century, most notably by Dr. W.C.
Alvarez. This physician published a
classic paper in 1924 titled “Intestinal Autointoxification” in Physiological Reviews (4:352-393). Dr. Alvarez
continued on next page
SPRING 2008
Table 1: Ingredients of a Natural Colon-Cleansing Formula
• Artichoke Leaf
• Ashwagandha Root
• Beet Leaf
• Burdock Root
• Chlorella
• Corn Silk
• Dandelion Root
• Arabinogalactans
• Milk Thistle 80%
• Mullien Leaf
• Red Clover Flowers
• Turmeric Root
• Aloe Vera 200:1 Concentrate
• Rhubarb Root
• Slippery Elm Bark
• Marshmallow Root
• Fennel Seed
• Ginger Root
• Triphala
• Magnesium (Hydroxide)
• L-Glutamine
• Fish Oil 50% Powder
Reproduced with permission of Holt MD Labs/Natural Clinician LLC).
stressed the notion that the mucus
membrane of the colon is very efficient
in preventing the passage of toxins
into the general circulation. However,
the defenses and functional nature
of the colon and are more complex
than was realized at the time that Dr.
Alvarez proposed his limited views of
“colonic life.” Early scientific work did
not deny the presence of many toxins
in the gut, but it described the colon as
an efficient, impenetrable barrier. Dr.
Alvarez reinforced the continuing, but
erroneous beliefs, that the colon is an
effective barrier to “toxins.” It is amazing how these old views of the colon
persist in modern allopathic, medical
belief systems.
Modern research has shown increasing evidence that the lining of the guts
is variably permeable to unwanted
agents. Several of these agents are present in the digesta, including infectious
organisms, toxic chemicals, bacterial
degradation products, etc. In fact, the
colon may be a site where some agents
are actually transformed and absorbed
SPRING 2008 in the body, especially when transformation is by bacteria. Examples of this
phenomenon include the cleavage of
conjugated phytochemicals, such as
conjugated soy isoflavones (glycones).
This cleavage occurs by enzyme activity that is present in some gut bacteria.
The Importance of Residence Time
of Colon Contents
The residence time of stool in the
colon is an important issue. Prolonged
residence of the digesta is a measure of
constipation or gut transit time. If stool
stays around too long, fermentation or
other biotransformations of chemicals
or undigested food may occur. Increasing residence time of “toxic” chemicals
in the digesta extends the time available for them to damage the colon
or facilitate absorption of potentially
noxious agents by the large bowel.
There is good reason to facilitate
bowel emptying in many people who
have constipation. This is ideally
undertaken by correct lifestyle adjustments (e.g., adequate roughage, fiber in
the diet, balanced nutrition, avoidance
of toxic chemicals, exercise, etc.). On a
selective or intermittent basis, purgation or the facilitated exodus of the colonic digesta by gentle means is often
a refreshing or pleasurable experience
with clear implications for good health.
The idea of cleansing the body by the
elimination of toxic reservoirs (e.g.,
stool or intestinal parasites) and the
promotion of detoxification are neither
novel nor new. Cleansing and detoxifying the body is deeply rooted in traditional medical practices, over a period
of thousands of years, in Ayurvedic
medicine, traditional Chinese medicine,
and North American Indian medicine.
Herbs and botanicals used in these
ancient medical practices are used in
these ancient medical practices are
used in modern, colon cleansing products (Table 1).
Lesson From Ayurveda
Ayurvedic medicine teaches prominently that the main cause of much
continued on page 8
❘ 7
Gut Detoxification continued from page 7
illness is poor digestive function.
For thousands of years this discipline
of medicine has proposed that food
resides in the colon and becomes a
source of toxins, as a consequence of
fermentation, especially in the presence of unfriendly microorganisms,
such as yeasts or miscreant bacteria.
These concepts have led to diets and
herbal concoctions which are believed
to cleanse the body when applied in a
tailored manner (Table 1).
The ancient medical discipline of
Ayurveda, with its focus on colon
cleansing and body detoxification,
cannot be ignored given its established precedent for health benefits.
Prominent in Ayurvedic treatments are
healthy lifestyle, Pancha Karma (detoxification by cleansing) and the use
of cleansing, detoxifying and rejuvenating herbs or botanicals.
Body Toxins and the Colon
Toxins are any agents that can damage cellular, tissue or organ function.
Our “advanced” lifestyle coupled with
the modern industrial revolution has
made environmental toxins ubiquitous. In modern times, humankind
has experienced greater levels of body
toxicity. The modern, “intoxicating”
environment has contributed greatly to
the phenomenon of autointoxication.
The colon is a reservoir of inner toxins
and it is accepted reasonably that many
toxins are the cause of acute, subacute
and chronic disease.
Many people can decrease their toxin
load by altering day-to-day preferences
and lifestyle. It is valuable to teach patients simple tips that may help them
cut down on exposures to environmental toxins. Such advice can make
a profound contribution to health and
well-being.
An Expanded Understanding of
General Intoxification
Many toxic substances do not remain
in the environment in their original
form or structure. These toxins are
transformed by a variety of inorganic
or biological processes. Chemical
8 ❘
toxins (e.g., pharmaceuticals) are often
degraded by the body and converted to
molecules linked to other compounds
or smaller molecules. In contrast, toxic
metals are not broken down, but are
often converted into available or nonavailable chemical forms.
The speed with which organic toxins
are broken down is very variable.
For example, organophosphates may
be metabolized in minutes or hours,
whereas polychlorinated biphenyls are
degraded only after many years. These
chemicals can lurk in body fat, where
they drive disturbed body metabolism.
The pot belly is composed sometimes
of toxin-laden fat which is akin to an
unwanted dysfunctional endocrine
organ. Understanding the chronological
events of toxin activation or inactivation has major implications for attempts
to cleanse the body. Organic toxins are
most often ingested orally, making these
latter concepts relevant to gut detoxification mechanisms and other factors
such as colonic residence time.
Of partial relevance to the function
of colon and its attempts to detoxify
are the modifications of toxic chemicals that can be made by microbial
species. Bacteria can degrade toxins
effectively in many contexts, but they
can also elaborate toxins from otherwise nontoxic compounds. Organic
toxins are most often degraded by microorganisms in the environment and
friendly bacteria in the colon (probiotics) are capable of degrading or detoxifying several organic toxins. Industrial
experiences with attempts to detoxify
the environment have occurred by
isolating and culturing bacteria that
detoxify organic chemicals, after their
successful seeding into a contaminated
environment. We have a corollary in
medicine whereby the same processes
may occur with probiotic therapies
which “clean” the colonic environment,
while presenting added benefits beyond
the process of “detoxification.”
Practitioners of alternative medicine are very familiar with the use of
intravenous chelation for the removal
of heavy metals within the body, but
they may be less familiar with the ability of many herbal or botanical, natural
compounds that can “detoxify” metals
by the formation of complexes with
organic compounds that share electrons through the process of chelation.
Many phytonutrients can potentially
chelate and produce unavailable metallic complexes which cannot cause body
toxicity. Interval oral chelation with
supplements is advantageous in many
individuals, but oral chelation is not a
substitute for intravenous chelation.
One example of this concept is the
knowledge that elemental mercury has
relatively low toxicity, but is extremely
damaging and hazardous in its methylated form. In brief, body processes
that facilitate detoxification depend on
many different chemical reactions of
an inorganic or organic nature. Against
this background, I propose combined
techniques for whole-body detoxification which may involve direct cleansing procedures such as controlled
fasting, well-selected diets, herbal or
botanical agents with “cleansing” ability, saunas, hydrotherapy and colonic
irrigation, to name a few approaches.
Cleansing, Detoxification and
Rejuvenation of the Gut
While this article has attempted to
focus on the colon as a “major sewer”
for body cleansing, clinical practice
presents many options that may be
used together simultaneously to promote cleansing or detoxification. I support the use of intravenous chelation
as a very effective way of decreasing
heavy metal contamination, but I stress
that it is only one of several pathways
available for detoxification.
The liver is the key detoxifying organ
with its ability to filter blood, engage
in complex chemical reactions and
excrete bile. The skin excretes compounds in sweat and the kidneys are
the main portal of excretion from the
body. Less attention is placed on the
lungs as a major organ of detoxification, but volatile chemicals are found
in expired air in large amounts in both
SPRING 2008
states of health and disease. I assert
the major importance of the colon in
eliminating unwanted chemicals of all
types and heavy metals in the stool.
It is important to remember that the
tubular digestive tract has complex enzyme systems, unique physical environments and complex immune functions
that can all contribute to detoxification.
While detoxification is important, the
process of supporting or rejuvenating
the complex harmony of the bowel
is pivotal in sustained attempts to
achieve body cleansing.
Complex attempts at body detoxification are procedures that can be made
less necessary by good patient advice.
Such advice can result in less toxin exposure and overall disease prevention.
While I have focused on several issues
relevant to digestive harmony and
body cleansing, there are many obvious forms of toxicity that result from
the day-to-day practice of usual and
customary medicine – e.g., the widespread and often inappropriate use of
nonsteroidal anti-inflammatory drugs
(NSAIDs).
Preventive efforts to avoid body
toxicity include the use of simple,
gentle, natural first-line options to
manage common ailments. For example, NSAIDs are one of the common
causes of gastrointestinal disorder, but
they are the most common drugs prescribed or used over the counter. These
NSAIDs are common causes of dyspepsia, general gastrointestinal upset,
liver dysfunction, impairment of renal
function, upper and lower gastrointestinal bleeding, and defuse damage to
gastrointestinal mucosal barriers. Aside
from their selective propensity to cause
heart attack or stroke, they have been
overlooked as a common source of
damage in the lower gastrointestinal
tract, where they break mucosal barriers and facilitate the entry of toxins
or allergens. I mentioned NSAIDs as
one obtuse, but highly relevant factor
in promoting general body toxicity.
Topical, natural pain-control rubs and
several oral supplements are viable
alternatives to NSAID usage.
SPRING 2008 I believe strongly in the idea of
cleansing the gastrointestinal tract with
a high-fiber, balanced diet combined
with good fluid intake and exercise.
An important adjunct to this cleansing
activity is the use of osmotic laxatives
that are combined with complex herbal formulae. These formulae have their
roots in body cleansing in Ayurvedic
or other forms of traditional medicine,
complemented by modern naturopathic approaches. Table 1 provides an
example of a colon -cleansing formula
that may be used on an intermittent,
semi-continuous or continuing basis,
depending on clinical circumstances.
Detoxification is incomplete without
supporting liver function and using
probiotic therapy. Good techniques
for rejuvenation of gastrointestinal
function which secondarily improves
continuing detoxification include the
use of dietary supplements such as
omega-3 fatty acids, potent REDOXbalanced antioxidants and probiotics,
supported by prebiosis with fructoligosaccharides (FOS) or selected soluble
fiber (especially hydrocolloid, soluble
fractions of oat fiber, beta-glucans).
Emerging Concepts in Toxic
Exposures
While body cleansing remains a common practice in integrative medicine,
the practice of detoxification struggles
to find an evidence base. It is notable
that attempts to rid the body of “poisons,” real or perceived, have been made
from time immemorial. Recent experiences with detoxification treatments
of rescue workers involved in the 9/11
disaster have provided real insight into
the value of intensive, acute detoxification procedures, using extended sauna
therapies combined with exercise and
vita-nutrient supplementation.
Environmental toxins during the
9/11 catastrophe included asbestos,
toxic heavy metals, other inorganic or
organic disease-causing chemicals and
other unidentified health-damaging
agents. Evidence-based strategies exist
to minimize toxin load following exposure to several toxic agents. The New
York Rescue Workers Detoxification
Program applied classic detoxification
methods to hundreds of exposed victims,
using a vitamin-supplement regimen,
sauna exposure, aerobic exercise and
lifestyle advice, with clearly documented improvements in presenting
symptoms that could be attributed to
toxin exposure during the 9/11 events,
together with objective evidence of
reduction in toxic load, as measured by
laboratory testing in a selected number
of victims. With clarity, the victims reported consistently a reduction for the
need of drug prescriptions, in circumstances where some rescue workers
were receiving extreme polypharmacy
(oral medication and inhalers).
Progression of disease from the toxic
exposures of 9/11 is evolving and
documented in the medical literature,
including deaths, reports of low birth
weight, cancer, chronic respiratory
disability and other disorders. The
consequences of heavy-metal exposure
and excessive free-radical load can be
forecast in the exposed populations,
but a concerted effort at detoxification remains quite limited by resources
and continuing arguments about the
lack of efficacy or evidence base for
detoxification methods. The premature
disability and death that could affect
thousands of citizens (up to 1.2 million) in a significant radius of one of the
highest population densities in the world
is a major public health initiative that
remains somewhat mismanaged. There
is an urgent need for amalgamation of
outcome data on detoxification practices,
utilizing non-allopathic interventions.
The outcome data from the first
1,000 treated 9/11 rescue workers is
in an advanced stage of compilation
and analysis. While the emergence of
illness related to toxicant exposure can
be linked to the known outcome of
specific types of poison, the occurrence
of unexpected outcomes has become
apparent. A large proportion of the
rescue workers developed accelerated
weight gain, combined with sleeplessness. Many individuals seemed
continued on page 10
❘ 9
Gut Detoxification continued from page 9
Table 2: CDR Approaches, Simplified and Facilitated
Cleansing
High-fiber, balanced diet, good fluid intake, exercise, osmotic laxative
(e.g., magnesium sulphate), as required.
Detoxification
Silymarin, modified fasting, probiotic therapy and other alternative
approaches.
Rejuvenation
Nutrient support for gut function and probiotics present a sound option.
CDR Facilitated
Magnesium sulphate orally and mixed fiber supplements in the absence of
contraindications and used occasionally, e.g., epsom salts, milk of magnesia.
See Colon Cleansing Table 1.
Cleansing
Silymarin.
Detoxification
Probiotic formula, enteric-coated for viability, containing at least
Lactobacillus with FOS.
Fiber supplements administered with glutamine, antioxidants, omega-3 fatty
acids, glutathione, ginger, vitamins, trace minerals.
Rejuvenation
to emerge with a pattern of metabolic
disturbance, similar to Syndrome X.
The notion that toxic insults to the
body may propagate weight gain has
been suspected for several years. This
circumstance has led to a new and novel
concept of “toxin-induced lipogenesis.”
Evidence exists that there is a positive
correlation between the increased use
of synthetic chemicals and weight gain
over the past two or three decades. The
most notable examples of chemicals
causing weight gain are carbamates,
organophosphates, organochlorines,
antibiotics, certain pharmaceuticals,
several hormones and their analogues.
The mechanisms of lipogenesis that are
induced by chemical pollutants include,
but may not be limited to interference
with fat metabolism and altered hormonal-type effects on the regulation of
appetite. The increasing evidence that
environmental toxicity may promote
obesity supports the routine use of body
cleansing or detoxification as part of
weight control programs.
Relevance to Anti Aging Medicine
10 ❘
The focus of this article on gut detoxification and general body cleansing
introduces the important concept of
toxicant-induced damage as a clear
cause of premature death and disability. Many environmental pollutants
concentrated in the body over a lifetime may combine with poor gastrointestinal function to aggravate oxidative
damage to many body tissues. One may
now perceive an emerging, complex
web of premature disease induced by
the failure of the physiology of modern
humankind to deal with an increasing
toxic environment.
and water filtration, etc. The concepts
of herbal support for detoxification
appear quite valid (Tables 1, 2). While
detoxification of the gut represents
only one important pathway to body
cleansing, a number of natural substances may provide excellent nutritional support for body detoxifying
mechanisms, e.g., silymarin, probiotics,
omega-3 fatty acids, etc. This approach
is part of a recommendation for cleansing, detoxification and rejuvenation
(CDR) of the digestive tract (Table 2).
Conclusion
1. Holt S. Natural Ways to Digestive Health. New York:
M. Evans and Company, Inc., 2000.
Body cleansing is a very important
component of anti-aging medicine and
its application may have been underutilized. In general, cleansing of the
bowel and body are functions of good
lifestyle habits. There are several preventive efforts that can result in better
health and well-being, e.g., reduction
of substance abuse, alternatives to
drugs (especially NSAID), avoidance of
ingested or inhaled synthetic chemicals
REFERENCES
2. U.S. Tariff Commission. Synthetic Organic Chemicals, Flegal KM. Overweight and Obesity in the
United States.
3. Baillie-Hamilton P. The Body Restoration Plan. New
York: Penguin Platinum, Inc., 2002.
4. Holt S, Saleeby G. Gastric mucosal injury induced
by anti-inflammatory drugs (NSAIDs). South Med J,
1991;84(3):355-360.
5. Holt S, Irshad M, Howlen CW, Maneiro M. Nonsteroidal anti inflammatory drugs and lower gastrointestinal bleeding. Dig Dis Sci, 1993;38:1619-23.
SPRING 2008
PRODUCT Announcements
◗ Fermented Wheat Germ Extract (FWGE):
Truly Unique Dietary Supplement - Avé™
Avé™, from American BioSciences, winner of the NutrAward for “Best
New Product”, is the first dietary supplement available in the U.S. to contain the novel nutrient, “Fermented Wheat Germ Extract, “ (Avemar®.)
Its development was initiated by Albert Szent-Gyorgyi, Nobel Prize
laureate for the discovery of vitamin C. Avemar has been the subject of
over 20 peer-reviewed research publications. Once daily use is shown
to support healthy cell metabolic regulation in vulnerable cells and
promote immune system modulation, resulting in healthy cellular and
humoral (Th1/Th2) immune system balance.
For literature and research, contact: American BioSciences, Inc, Blauvelt, NY,
(888)884-7770, www.americanbiosciences.com.
◗ NanoProPRP Whey Protein
with Colostrum Peptides
NanoProPRP, Whey Protein with Colostrum
Peptides, provides a scientifically formulated
blend of the undenatured whey and bovine colostrum, synergistically fortified with carefully
selected nutrients to help support tissue repair
and regeneration, optimize endogenous antioxidant status, promote detoxification and modulate immune function. As BioPharma motto
is “blending high science with high compliance”
you can be sure NanoProPRP also tastes great.
Each 18 gm scoop provides 12 gm of protein,
2 gm of colostrum (fortified with proline-rich
polypeptides AKA PRP, info-peptides, transfer
factor), 2 gm inulin, 50 mg reduced glutathione
in our patented NanoSorbTM liposome, 40 mcg
of organic selenium plus lactase.
BioPharma Scientific
www.nanogreens.com/free
Free week supply call 1-877-772-4362
◗ Amici Scalp & Hair Loss
Diagnosis System
The Amici Scalp & Hair Loss Diagnosis System, which includes
software and diagnostic microscope, provides a scientific method
to guide doctors to reach an accurate diagnosis through built-in
diagnosis templates. The system enables doctors to analyze different hair loss cases, their causes, the extent and progression of
hair loss through the scalp exam, hair thickness exam, hair density
exam and phototrichogram analysis. Phototrichogram is especially
a powerful scientific method to analyze hair loss since it measures
the ratio of live hairs to dead hairs, and therefore predicts hair loss
objectively.
Most scalp & hair loss diagnosis systems in the market are just
a modification from skin care analysis systems and do not provide sufficient information for scalp & hair loss diagnosis, except
magnifying and showing scalp conditions. However, our system is
specialized for hair loss only
and guide doctors step-bystep to reach an objective
diagnosis and personalized
treatment suggestions.
Amici 0.3 Corporation
Telephone: 847-259-3600
Fax: 847-253-7610
Email: [email protected]
Website: www.amici03.com
◗ ApothéCure, Inc. introduces Phosphatidylcholine/ Deoxycholic Acid
(DCA) for Lipodissolution and Cardiovascular Disease
ApothéCure, a world-renowned compounding pharmacy, offers a wide variety of compounds formulated for Mesotherapy, Lipodissolution and all aesthetic applications. The most popular selling product, Phosphatidylcholine / Deoxycholic
Acid 5/4.2% 50ml, is specifically designed for Lipodissolution. Also offered are varying strengths of PC/DCA in IV form
that are used by physicians to treat cardiovascular disease.
These products are only offered to physicians and not available to the
public. Contact: ApothéCure, Inc., 800-969-6601 or 972-960-6601.
E-mail: [email protected]
SPRING 2008 ANTI-AGING MEDICAL NEWS
❘ 11
◗ CRT 2000® THERMOGRAPHIC
SYSTEM
◗ Non-Surgical LipoSculpture for
Facial Anti-Aging
Retain youth and longevity by promoting early detection. Examine patients knowing you can help provide
them with treatments specific to their individual health
needs. Non-invasive. No radiation. Painless procedure.
Safe for patients and health care professionals. The CRT
2000® Thermographic System uses a highly sensitive
heat sensor to examine 119 significant points on the
body to help identify disease processes. In 30 minutes,
receive a comprehensive profile and report on your
patient’s health to help you develop more effective
treatments and protocols.
Since 60% of Americans are overweight, many agerelated changes of the face are due to fat drifts or bulges
rather than from volume loss, resulting in: sunken eyes,
naso-labial folds, diminished cheek bone prominence,
jowls, double chin, etc. Dr. Mahmud has pioneered
a method to sculpt out these drifts and bulges, using
appropriate injections of natural substances, thus
smoothening and restoring younger faces. The patient
satisfaction rate is 90%, and has made an immense
difference in the lives of many of his patients. This work
is featured in the April 2008 meetings of A4M.
For more information: Eidam Diagnostics Corporation
Toll-Free: 1-866-798-4CRT (4278) • www.eidam.com
Innovative Directions in Health
4005 West 65th Street, Suite 212, Edina, MN 55435
952-922-2345
www.idinhealth.com
◗ Canfield introduces the Reveal Imager;
revolutionary new facial imaging solution
The Reveal Imager from Canfield Imaging Systems is designed to take
high quality standardized and reproducible facial photographs in almost
any environment. This new system captures images of surface and subsurface skin features and will photograph front, left, and right views. With
an easy-to-use interface anyone in a skin care office can take professional,
repeatable facial photographs.
The Reveal Imager uses Canfield’s proprietary RBX™ Technology to
detect subsurface vascular (red) and melanin (brown) conditions and
develop highly targeted treatment recommendations. Designed for the
skin care counter, it is ideal for spas, medical spas and traditional medical
practices.
Availability is scheduled for spring of 2008.
For additional information: Canfield Imaging Systems 800-815-4330
www.CanfieldSci.com.
◗ POLY-MVA
The most powerful and revolutionary supplement available, POLY-MVA is designed to increase energy, protect from free
radical damage (which influences and accelerates aging), reduce fatigue, enhance optimum health, and provide superior
nutritional support. This patented formulation has a synergy, action and function not found in any other supplement. With
over 12 years of research and testing, POLY-MVA is first in a remarkable new category of supplements called palladium
lipoic complexes. Binding palladium-a rare trace mineral with
alpha lipoic acid-a powerful antioxidant dramatically increases
nutrient absorption at the cellular level and throughout the body.
Contact AMARC Enterprises at 866-765-9682 or www.POLYMVA.com.
12 ❘
SPRING 2008
◗ Isagenix International
Isagenix International, promotes a full line of anti-aging, weightloss and total health systems. The foundation of this
system is a revolutionary nutritional cleansing technology promoting internal health, leading to anti-aging, fast and safe
weightloss. Isagenix also offers the Mars Venus Wellness Solution, designed by Dr. John Gray for the unique health needs
of men and women.
Systems include the 9-day Cleanse, 30-day Cleanse, the Total Health and Wellness System and Isadermix System.
Features Isadelight, nutritional chocolates for improved brain chemistry/appetite suppression, and Ionix Supreme, an
adaptogenic tonic based on world longevity and health practices.
Contact: www.gocleanse.com/bodywise, Dr. Nina Elshiekh (919-219-3517), [email protected].
◗ New Health Corp
◗ Jan Marini Skin Research
New Health Corp. is proud to announce Heart
Savior, the first Natural Cholesterol lowering, heart
health product of its kind.
Heart Savior has been clinically proven to
lower LDL cholesterol by up to 34%, VLDL and
triglycerides by up to 76% while lowering blood
pressure without any side effects during the trial.
Heart Savior has taken the most effective
cholesterol lowering formula and added the vital
ingredient Co-Q10. Co-Q10 is known to reverse the
aging process of the heart.
It decreases with age and
low levels appear in patients
with heart disease and
diabetes and those taking
certain prescription drugs.
Age Intervention Transitions is an extraordinary new technology that addresses common
female transitional issues such as stubborn adult acne as well as fine lines
and wrinkles, coarse skin texture
and discoloration. Age Intervention
Transitions resolves or minimizes
acne breakouts while dramatically
improving the appearance of follicle
size, fine lines, rough facial texture
and that nasty leftover acne
discoloration. Age Intervention
Transitions combines acne
clearing and prevention with
remarkable skin resurfacing
and brightening technology.
No more stubborn acne —
just clear, radiantly polished
and younger looking skin.
Contact information:
Gary Stanton, President
New Health Corp.
www. heartsavior.com.
Tel: 1-877-263-3555
For more information, please call
(800) 347-2223 or visit
www.janmarini.com.
◗ Living Younger Preventive-Aging Medicine
& Business System
Jumpstart your own profitable preventive-aging practice quickly and
affordably. Widely used because of its all-inclusive clinical and business tools
just for preventive-aging practices. Everything is organized in the 1900-page
manual. Hundreds of customizable ready-to-use templates and forms on
CDROM. Step-by-step guidance for human performance evaluation,
functional age assessment, and preventive-aging consultations.
Exhaustive clinical guidelines integrate comprehensive HRT, exercise,
nutrition, supplements, stress management, and lifestyle. Extensive
education material. Market your practice immediately with readyto-use, modifiable brochures, pamphlets, articles/advertorials,
PowerPoint presentations. Boost your income with comprehensive
instructions, contracts and forms – and no franchise fees.
www.LivingYoungerPreventive-Aging.com.
❘ 13
◗ Power Plate®
Power Plate® machines are a revolutionary modality that offers healthcare
practitioners an adjunct method to treat their patients. Using Acceleration
Vibration TechnologyTM Power Plate machines stimulate your body’s natural
response to vibrations to help improve muscle endurance, stimulate circulation
and performance. The whole body vibration technology behind Power Plate
machines is appropriate for the treatment of various ailments afflicting an aging
population, addressing conditions ranging from debilitating illness to cosmetic
issues. Benefits include: cellulite reduction, increase of metabolic functions,
increase in bone mineral density, and improved muscular tone and stability.
Contact: Power Plate Healthcare
877.87.PLATE
www.powerplatehealthcare.com
◗ Metabolic Optimizer™ Protocol
Dysfunction in any organ (heart, brain, kidney, skin, etc.) or
system can often be traced to a dysfunction in ATP production.
The Rejuvenation Science® Metabolic Optimizer™ protocol
consisting of L-Carnitine, Coenzyme Q10 Ubiquinol, and
D-Ribose is formulated so you can adjust the component dose
based on individual patient need.
Our Metabolic Energy brochure describes how this theory
of ATP dysfunction applies to many body systems including
cardiovascular health (Sinatra, MD), normal DNA and brain
function (Ames, PhD), lower incidence of pain and migraine
headache (Teitelbaum, MD), skin health and body weight
(Perricone, MD).
Contact Rejuvenation Science® at 888-73-REJUV or www.rejuvenation-science.com/metabolic-energy.html or
A4M booth 1022 Orlando, FL.
◗ BREAKTHROUGHS IN COLLAGEN PURIGENEX BIO-ACTIVE INTENSIVE
collagen formulas offer:
A truly trans-dermal, non-immunogenic form of collagen (atelocollagen) with no side effects.an active compound
derived from bio-compatible animal sources that the human body can recognize and assimilate. a proprietary ionized
formulation to enable optimal penetration into the
skin’s own collagen network.
Regular, directed use of ICS and ICM will boost the
skin’s own collagen integrity and increase dermal cell
regeneration, to make skin appear plumper, smoother,
more supple, and more youthful. Researchers’ studies
have shown measurable improvement with these
products following only four weeks of combined therapy.
PURIGENEX collagen must be kept refrigerated,
distinguishing it from many other cosmetic preparations
containing collagen as a gelatin (an inactive, incomplete
compound that will have no effect on cell proliferation
or function).
Contact: 877-787-4469 / [email protected] / www.purigenex.com
1821 Wilshire Blvd Suite 300, Santa Monica, CA 90403
14 ❘
SPRING 2008
◗ Introducing jane iredale’s Just Kissed
This summer jane iredale – The Skincare Makeup® brings you a runway inspired collection.
New Just Kissed,$24 a rich formulated lip plumper and lipstick in one. It comes
in three shades, Milan, Sydney and NYC.
Formula Benefits
• Spearmint and peppermint oils, in combination with ginger root extract stimulate
blood circulation to making lips fuller.
• Sunflower oil and aloe vera soften and hydrate,
• Essential oils of lemon and tangerine help to exfoliate flaky skin cells
• Unique time release activates one ingredient as the other wears off to ensure
lips stay plump
Visit www. janeiredaledirect.com for retail locations.
◗ Introducing jane iredale’s New Powder-Me SPF
~Sun-Kissed, Not Sun-Damaged~
This summer jane iredale – The Skincare Makeup® Powder-Me SPF, $44 is an
all over face and body powder that protects the skin from UVB and UVA rays.
Benefits:
• Physical, not chemical, sun protection that works instantly
• Packaged in an innovative dispenser for quick and even coverage
• Applicator has a mirror for fault-proof application
Non-Irritating Formula
• Includes active ingredients like titanium dioxide and a unique clay that
contains minerals to nourish and calm the skin
• Completely free of contaminants and atmospheric pollutants
• All natural ingredients
Available in two shades: Translucent and Tanned
Visit www. janeiredaledirect.com for retail locations.
AGE DIAGNOSTIC LABORATORIES The Reliable Testing Partner for Your Anti Aging Practice
When it comes to testing, you need a Laboratory that you can trust, one that provides you with the highest degree of
precision and accuracy, and that only a state of the art technology can offer.
Our International Laboratory Consortium backed up by 20 years of industry experience is here to serve you with a
specialty testing for hormones and related biomarkers of aging.
Age Diagnostic Laboratories offers you:
• Complete Urine and Saliva Tests- done by bio-available technologies.
• Variety of treatment options – From Pharmaceuticals to Neutracuticles, Herbs and Supplements Suggestions
• Continued consultations and educational support provided by our Medical Director Dr. Mitchell Ghen
Contact: 877-983-7863 / [email protected]
Visit us at www.adltests.com
❘ 15
Bio-identical Hormone
Restoration in Women
By Sangeeta Pati, MD, FACOG
Restoration of low thyroid, insulin and
cortisol is the medical standard. So, it
seems logical to also replace low estrogen,
progesterone and testosterone. However,
the evidence leaves clinicians at a loss
for clear direction because of conflicting results from studies using varying
types of hormones, routes and ages. This
paper analyzes the existing data and puts
forth an argument as to why physiologic
hormone ratios are protective and why
these ratios are best achieved with the use
of bio-identical hormones, transdermal estrogen, starting in early menopause before
disease sets in.
Why restore Hormone Balance
Hormone receptors for estrogen, progesterone and testosterone are present on
the cells of the heart, blood vessels, bone,
nerves, muscles, skin and most cells in
the body. When these hormones become
imbalanced, women acquire an increased
risk of heart attacks, strokes, cognitive
decline, osteoporosis and breast cancer.
A comprehensive analysis of data shows
that restoration of normal physiologic
ratios of hormones is beneficial in alleviating symptoms and more importantly
degenerative disease. But what type is
protective? What route is protective and
to which women?
Normal Protective Hormone Ratios
There are three predominant estrogens
in nonpregnant, premenopausal women:
estrone (E1), estradiol (E2) and estriol
(E3) at a ratio of E1 10 percent to 20 percent, E2 10 percent to 20 percent and E3
60 percent to 80 percent (see Table 1)1.
This ratio is protective, since the thrombogenic and carcinogenic effects of E1 are
limited by its relative low ratio. E1 can be
metabolized to methylated products that
are excreted safely by the liver.2 However,
if the liver systems are overwhelmed or
methyl groups are deficient, E1 is converted to quinones (i.e. 4-OH or 16-OH),
which are mutagenic and carcinogenic.3,4
16 ❘
E2 is the strongest estrogen for brain and
bone protection.
Hormone ratios in the
perimenopause and menopause
Hormone decline starts around age 30
when progesterone levels start to wane.
This can produce a myriad of symptoms
which are often not recognized as progesterone deficiency, including anxiety,
insomnia, panic attacks, heavier bleeding,
cysts (ovarian and breast), PMS, weight
gain, fibroids and bone loss. This period
is characterized by an overabundance of
estrogen.5
As menopause approaches, the ovarian production of estrogens declines;
however, due to the continued production of E1 by the adrenals and fat tissue,
it becomes the predominant estrogen,
rising to 60 percent to 80 percent of
estrogen while E2 and E3 are each
reduced to 10 percent to 20 percent. It
is this overabundance of E1 and the lack
of E3 and progesterone that predisposes
menopausal women to breast cancer,
stroke and heart attack.
Bio-Identical Hormones Can Mimic
Protective Ratios
To re-establish the normal protective
ratio, a 20:80 ratio of bio-identical E2 to
E3 can be used, avoiding E1 altogether.
Horse-derived, soy and yam hormones
do not fit into the human receptor exactly. Bio-identical hormones are exactly
identical to the hormones of the human
body, molecule by molecule. Since, they
fit the hormone receptor like a key fits
into its lock; the body cannot distinguish
between a bio-identical hormone and
the hormones it makes itself. They are
often created from soy or yam hormones
by removing any molecules that do not
exist on the human hormone counterpart. They can also be made synthetically
in the laboratory, for example Climara
patch (from soy) or Vivelle Dot (from
Mexican yams), which are both bio-
identical 17-beta estradiol.6 Also, prometrum is a bio-identical progesterone
in peanut oil. All of these patented products are FDA approved and therefore
any attempt to claim there is no data for
bio-identical hormones should be carefully scrutinized.
Transdermal estrogen mimics normal
ratios better than oral, since oral estrogen
first passes through the liver, where 50
percent is converted into estrone sulfate
(E1) before circulating to tissues. Transdermal estrogen enters the circulation at
the ratio applied to the skin. A body of
literature suggests transdermal estrogen
decreases thrombosis, blood pressure,
triglycerides and vascular resistance, as
opposed to oral estrogen, which increases thrombosis, blood pressure, CRP,
triglycerides, gallstones and liver-binding
proteins.7-14
What’s wrong with the Women’s
Health Initiative (WHI)15?
The WHI included 16,600 women
(average age: 63) in 40 centers from
1997-2002. They used conjugated
equine estrogen (CEE) with 50 percent
E1, 0.5 percent E2, no E3 and 40 percent horse equilins (see Table 1). They
also used a non-bio-identical progestin,
medroxy-progesterone acetate (MPA),
which is both thrombogenic and carcinogenic. This may partially explain eight
more breast cancers, eight more strokes,
seven more heart attacks and 18 more
peripheral clots per 10,000 women. Interestingly, the WHI released results for
the estrogen-only arm in 2002, showing
an almost-significant decrease in breast
cancer and cardiovascular disease.16 WHI
showed a decreased risk of hip fracture
and colon cancer at a rate of six per
10,000 women. Additionally, reanalysis
revealed that the decreased mortality
from hip and colon cancer far offset the
increased mortality from breast cancer.
The WHI greatly influenced the way
SPRING 2008
in which American doctors prescribe
hormones and the way in which American women receive them, with millions
of women stopping hormone replacement therapy (HRT) after the results
were heralded by the media. Although
this study has been the focus of much
criticism, there are actually several useful
conclusions from this study:
1. Early start HRT (Age 50-59) is protective on the heart as it may protect from
developing significant vascular disease.
Different findings may be found if
memory studies were done earlier rather
than starting at an average age 71.
2. Synthetic progestins, such as MPA,
have been found to increase breast
cancer and clots in several studies. Bioidentical progesterone should be used
instead.
3. Estrogens used transdermally provide
a safer profile of estrogens, due to
decreased estrone and decreased liver
stimulation of clotting factors. Also
Premarin is, of course, heavy in estrone
sulfate from the beginning.
4. The positive findings in the estrogenonly arm were unknown to many due
to lack of proper media coverage.
5. Quality of life is a major reason for
taking hormones, so this should be
part of any large hormone study.
Progestins vs. Bio-Identical
Progesterone
Progestins are vastly different in
molecular structure and function from
bio-identical progesterone. Bio-identical
progesterone was preferred by 34 percent
of women previously on MPA in a Mayo
Clinic study. Bio-identical progesterone
results in less bleeding, bloating and mood
swings,17,18 and better sleep19,20 than MPA.
It also leads to less breast-cell proliferation and less cell adhesion.21-23 From a
vascular standpoint, it decreases LDL24,
vasodilates25 and inhibits vascular smooth
muscle26 and vasospasm,27,29 compared
with MPA. MPA actually stimulates
vascular smooth muscle in coronary arteries,28 opposes vasodilation,30 decreases
NO31 and increases CRP32 compared
with bio-identical progesterone.33,34 The
WHI study demonstrated the increased
SPRING 2008 Table 1:
Estrogen Ratios1
Estrone (E1)
Estradiol (E2)
Estriol (E3)
Pre-menopasual
Non-pregnant
10-20 percent
10-20 percent
60-80 percent
Post-menopausal
60-80 percent
10-20 percent
10-20 percent
Premarin (CEE)
Oral
50 percent
0.5 percent
0 percent
vascular consequences of progestin since
the estrogen-only arm did not demonstrate the increased cardiovascular risk
seen in the CEE-MPA arm.15,16
Several studies support an increased
breast cancer risk with progestins,
including the WHI,15,16 Breast Cancer
Demonstration Project35 and Swedish Record Review36 with a 2, 8, and
2.5 fold increased risk of breast cancer,
respectively, when using MPA with CEE
compared to CEE alone. So, progestins
are more mitogenic and thrombogenic
than bio-identical progesterone.
Breast Cancer
The number-one fear expressed by
women when discussing HRT is the fear
of breast cancer. In perspective, the twoyear mortality for hip fracture is much
greater than the 10-year mortality from
breast cancer, and osteoporotic fractures
occur eight times more frequently than
breast cancer. In reviewing the data
regarding breast cancer and HRT (see
Table 2), a few things stand out:
1. The relative risks are not huge. A RR
0.5 to 1.4637,38 was found in a subset
of women who drank three to four
glasses of alcohol per week in the
Nurses Health Study.
2. Progestin is a possible culprit.
WHI15,16, BCDDP35 and the Swedish
Record Review36 all report increased
risk due to the addition of progestins
to CEE,40 and the breast mitotic index
increases more when progestin is
added to CEE.39
3. HRT does not increase recurrence
even in breast cancer patients. Nine
independent studies in five countries
(the United States, Australia, South
Africa, and Finland) failed to demonstrate any increased incidence of recurrent breast cancer with HRT.41,42
4. Hormone imbalance (i.e., low progesterone, high E1 and low E3) around
menopause plays a significant role in
the development of breast cancer: Progesterone reduces both proliferation43
and the uptake of E2 by breast cells.44
Low progesterone is associated with
a 5.4-fold increase of premenopausal
breast cancer.45 Excess E1 results in
excess production of 4-OH E1 and
16-OH E1, which are known to be
carcinogenic to breast tissue and are elevated in women with breast cancer.3,4
Declining E3 increases risk, since E3
is anti-proliferative to breast cells.46-49
So, restoration of hormonal balance is
highly protective against breast cancer
and breast cancer recurrence.
5. Nutrients and antioxidants are protective.50 Vitamins and antioxidants such
as vitamin E, vitamin C, vitamin A,
green tea, selenium, glutathione and
methyl donors (which detoxify excess
estrogen) have been found to be protective against breast cancer.
6. Toxins play a role in the development
of breast cancer. Pesticides, hormones
in meats, alcohol, petroleum products,
plastic byproducts and electromagnetic
radiation are proving to be associated
with all cancers and breast cancers at
an increasing rate. Of no surprise is that
many of these toxins stimulate the E1
receptor (thus the term xeno-estrogens)
and most of them lodge in fat tissue,
❘ 17
Bio-identical Hormone Restoration in Women thus the increased risk of breast cancer
with increased body fat, which harbors
more toxins.
Clearly the strongest prevention of
breast cancer lies in restoring a protective balance of hormones and nutrients
and avoiding and removing toxins.
Cardiovascular disease
MISC
First, the longer women hold on to
their normal balance of hormones, the
lower the incidence of cardiovascular
death.51 Why? Studies show that E2
causes vasodilation,52 improves vascular
wave function,53,54 decreases sympathetic
outflow55 and decreases vascular proliferation.56 Studies using transdermal E2
show that it decreases blood pressure,57-59
as opposed to non-bio-identical oral
E2, which may increase blood pressure.
Transdermal E2 is anti-thrombotic and
decreases fibrinogen.60-62 E2 decreases
arterial plaque by decreasing vascular
proliferation,63,64 reducing LDL and raising HDL.24 These cardiovascular benefits
follow the use of bio-identical E2. Nonbio-identical estrogens, such as CEE, can
have the opposite effect.65
Second, the sooner we replace hormones in the postmenopausal period,
the better – most likely because of the
ability of the hormones to prevent the
formation of plaque. When started late
(i.e., five years after menopause), hormones can increase rupture of existing
plaque. Both WHI (average age: 63)15,16
and HERS (average age: 67)66-,69 showed
increased cardiovascular risk in the
first year. All the women in HERS had
hypertension and coronary artery disease
(CAD). Analysis of the younger age
group in WHI (age 50-59) showed decreased risk of cardiac events (RR 0.56).
The Nurses Health Study (average age
52) found no increased CAD.70,71 Four
large prospective, randomized controlled
ongoing trials with 7,000 women (mean
age: 53) showed decreased CVD and
CVA (RR 0.17).72
TABLE 2:
continued from page 17
Summary of studies on HRT and breast cancer 37
N
Type
Duration
yrs
RR
Collaborative
group
52,705
Both
5-9
10-14
1.3
1.24
4 states
3,130
Case control
>5
0.7
Iowa Women’s
Health Study
1085
Cohort
>5
1.13
NHANES
219
Cohort
3-9
>10
0.5
0.8
Washington
State
537
Case-control
12-14.9
15-19.9
1.0
0.5
LA Cancer
surveillance
2653
Case-control
10-15
1.14
BCDDP
2082
Cohort
>15
1.36
WHI-2002
17835
Prospective
randomized
5.9
1.37
Nurses Health
Study
1935
Cohort
>5
1.0-Non-EtOH
4.6- EtOH
Study
Adapted -Monograph-Lifetime Hormonal Management 9/2001-USC School Medicine
Nurses Health Study and a NAMS
review both found that early HRT is protective against AD.73,75 Late-start HRT
is not protective as reported by WHI,
where the average age was 71.78-80 The
Cache County Study showed that when
continued for more than 10 years, HRT
reduced AD by 50 percent (fivefold).76
Several small trials show no protective effect when HRT is used for one
year.81,82 Hypothetically, this protective
effect with an early start may be due to
prevention of microvascular pathology in
the brain, as mentioned before.
Mood
Cognitive function
Normal levels and ratios of hormones
protect us from cognitive decline. When
HRT is started early and continued, it
is protective against cognitive decline
and Alzheimer’s disease (AD).73-77 The
18 ❘
Hormone restoration has a profound
beneficial effect on mood, since estrogen,
progesterone and testosterone receptors
are all over the brain (cortex, thalamus,
hippocampus, brain stem, amygdala, pituitary). Estrogen loss causes a decrease
in serotonin, leading to depression.83-87
Progesterone produces calmness and
sleep by binding directly to the GABA
receptor, just like Klonopin, Valium,
Xanax and Ativan. Progesterone replacement in women ages 35-45 with bioidentical progesterone leads to marked
reduction of anxiety, insomnia and the
need for medications.
Osteoporosis
Estrogen, progesterone and testosterone receptors are present on osteoblasts
and osteoclasts; thus the association of
declining levels with osteoporosis. Estrogen has little effect on bone formation.88
Studies (using both bio-identical and
non-bio-identical estrogen) show that
estrogen prevents bone loss by inhibiting
osteoclasts and bone resportion.90-92 E2
SPRING 2008
GIVE YOUR PATIENTS
A WAY TO TAKE OFF
CELLULITE, AND SEE
WHAT THEY GIVE YOU
IN RETURN.
Power Plate® machines and whole body
vibration use the body’s natural response
to vibration to stimulate involuntary
muscle contractions 25 to 50 times
per second. Proven benefits have been
reported by healthcare professionals in
the following areas:
Create a unique profit point for your
practice while your patients utilize the
Power Plate® machine. Contact one of our
Healthcare Specialists for more details.
Contact: 877.87.PLATE ask for Healthcare.
• Cellulite reduction
• Improved metabolic function
• Increase in bone mineral density
• Improved muscular tone and stability
• Improved balance and injury prevention
Visit us at the 16th Annual A4M
Booth #1003
April 25-27, 2008
H E A LT H C A R E
Copyright 2008 Power Plate North America Inc
Bio-identical Hormone Restoration in Women is significantly stronger than E3 in this
protective effect. Estrogen also protects
against loss of cartilage and osteoarthritis.
It is progesterone decline that accounts for bone loss occurring 10-15
years before menopause. Progesterone
actually stimulates osteoblasts and bone
formation.88,89 Similarly, testosterone
stimulates bone formation.93,94 Clinical
studies support the use of both synthetic
and bio-identical progesterone, estrogen
and testosterone for the prevention of
osteoporosis and bone fracture, even
when started late (i.e., WHI study with
35 percent fracture reduction).15
Colon Cancer
Sexual and urogenital function
Twelve randomized, controlled trials have shown a significant benefit to
sexual function with the restoration of
testosterone.97-99 Numerous studies have
shown the restorative effects of estrogen on the vaginal epithelium.100-102, 106
Therefore, estrogen (particularly through
the vaginal route) is used to relieve
vaginal dryness, vaginal relaxation, loss
of urine103-105 and recurrent urinary tract
infections.101 In fact, the use of vaginal
E3 relieves stress urinary incontinence in
a matter of weeks.
Conclusion
The closer we mimic the normal physiologic ratios of hormones, the better the
prevention of disease. Non-bio-identical
oral estrogens (i.e., CEE) provide too
much E1 (up to 50 percent), partly due
to their inherent makeup and partly
due to the liver pass effect via the oral
route. Bio-identical estrogens, especially
transdermal, mimic normal ratios better.
They have favorable anti-thrombotic and
vascular effects. Although, progestins
add cardiovascular risk, bio-identical
progesterone is anti-thrombotic and
breast cancer protective. The best stratANTI-AGING MEDICAL NEWS
egy for prevention of breast cancer lies in
restoring a protective balance of hormones and nutrients and avoiding and
removing toxins. Although, bio-identical
hormones mimic normal ratios better,
even studies using CEE support the use
of early HRT (<5years from menopause)
to reduce the risk of heart attacks and
breast cancer. There are a number of
patented bio-identical hormones that are
FDA approved and have been used for
many years. Physiologic hormone ratios
are safe to women and can be achieved
by the use of bio-identical hormones,
transdermal estrogen, starting in early
menopause before disease sets in.
women’s initiative randomized controlled trial. JAMA.
2002;288:321-333
16. Anderson GL, et al, Effects of CEE in postmenopausal
women with hysterectomy: the WHI randomized controlled trial. JAMA 2004;291:1701-1712
17. Fitzpatrick L, et al, Comparison of regimens containing
oral micronized progesterone or medroxyprogesterone
acetate on the quality of life in postmenopausal women:
a cross-sectional survey. J Women’s Health Gend Based
Med 2000;9:381-7
18. Cummings J, Comparison of physical and emotional
side effects of progesterone or medroxyprogesterone in
early postmenopausal women. Menopause. 2002 JulAug; 9(4):253-63.
19. Montplaisir J, et al, Sleep in Menopause: differential
effects of two forms of hormone replacement therapy.
Menopause 2001 Jan-Feb;8:10-16
20. Arafat ES, et al, Sedative and hypnotic effects of oral
administration of micronized progesterone may be mediated through its metabolites. Am J Obstet Gynecol,
Nov 1988;159(6):1203-1209
21. British J Cancer 1996; 73:1552-5-P inhibits breast cells
The WHI study reported six fewer colon
cancers per 10,000 women in the HRT
group.15 NAMS meta-analysis reviewed 18
studies and concluded that HRT reduces
colorectal cancer up to 34 percent compared with women who never used HRT
95
. One case-control study shows that the
risk reduction from transdermal estrogen is
greater than that with oral.96
20 ❘
REFERENCES
1. Wright J, et al. Comparative Measurment of serum
estriol, estradiol and estrone in non-pregnant, premenopausal women: a preliminary investigation, Alternative
Medicine Review, Vol 4, No. 4, 1999:266-70
2. Longscope C, et al, The metabolism of estradiol : oral
compared to intravenous administration. J Steroid Biochem 1985;23:1065-1070
3. Chen Y, et al, Metabolites of Synthetic Conjugated Estrogens are linked to development of breast
carcinoma. Chem Res Toxicol 1998 Sept; 11 (9)
94-101,1105-11
4. Cavalieri E, et al. Molecular origin of cancer: Catechol
estrogen-3,4 quinones as endogenous tumor initiators.
Cell Mol Life Sci 2002;59:665-681
5. Speroff L, Glass R, Clinical Gyn Endocrine and Infertility 5th ed, pg 592-3
22. Chang Kj, et al, Influences of percutaneous administration of estradiol and progesterone on human breast epithelial cell cycle in vivo. Fertil Steril 1995;63:785-791
23. Cancer Res 2002;62:881-886-MPA increases cell
adhesion
24. The Writing Group for the PEPI trial. Effects of estrogens or estrogen/progestin regimens on heart disease
risk factors in postmenopausal women: The PEPI trial.
JAMA 1995;273:199-208, JAMA 1995;274:1676
25. Rosano G, et al, Natural Progesterone, but not MPA,
enhances the beneficial effect of estrogen on exerciseinduced myocardial ischemia in postmenopausal women. J Am Coll Cardiol 2000; 36:2154-9
26. Carmbody B, et al Progesterone inhibits human infragenicular arterial smooth muscle cell proliferation induced
by high glucose and insulin concentrations. J Vasc Surg.
2002 Oct;36(4):833-8.
6. Reed-Kane D, Int J Pharm Comp 2001, 5 (5), 332-341
27. Molinari C, et al, Effect of progesterone on peripheral
blood flow in prepubertal female anesthetized pigs. J
Vasc Res 2001;38:569-577
7. Erenus M, et al, Comparison of effects of continuous
combined transdermal with oral estrogen and oral progesterone replacement therapies on serum lipoproteins
and compliance.Climacteric 2001;4:228-234
28. Seeger H, et al, Effect of MPA and norethisterone on
serum-stimulated and estradiol-inhibited proliferation
of human coronary artery smooth muscle cells, Menopause 2001 Jan-Feb; 8(1):5-9
8. Adami S, et al, Long term effects of transdermal and oral
estrogen on serum lipids and lipoproteins in postmenopausal women. Maturitas 1993;17:191-196
29. Miyagawa K, et, al, MPA interferes with ovarian steroid protection against coronary vasospasm. Nat Med
1997 Mar 3 (3):324-7
9. Meschia M, et al, Effects of oral and transdermal
hormone replacement therapy on Lipoprotein A
and lipids: a randomized controlled trial. Menopause
1998;5;157-162
30. Wakatsuki A, et al. Effect of MPA on endotheliumdependent vasodilation in postmenopausal women
receiving estrogen. Circulation 2001;104:1773-8
10. Langer RD, Strategies to optimize the safety of hormone therapy, OBG Management. Nov 2004
11. Vehkavaara S, et al, Effects of oral and trandermal estrogen replacement therapy on markers of coagulation,
fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women. Thromb Haemost
2001 Apr;85(4):619-625
12. Vongpatanasin W, et al, Differential effects of oral
versus transdermal estrogen replacement therapy on Creactive protein in postmenopausal women. J Am Coll
Cardiol. 2003;41:1358-1363
13. Post MS, et al, Effect of oral and transdermal therapy on hemostatic variables associated with venous
thrombosis: a RCT. Arterioscler Thromb Vasc Biol.
2003;23:1116-1121
14. Hemelaar M, et al, Effects of transdermal and oral
postmenopausal hormone therapy on vascular function: a randomized, placebo-controlled study in
healthy postmenopausal women. Menopause 2005;
12(5):526-535.
15. Writing Group for the Women’s Initiative Investigators.
Risks and benefits of estrogen plus progestin in healthy
postmenopausal women. Principal results from the
31. Williams JK, et al, Effects of hormone replacement
therapy on reactivity of atherosclerotic coronary
arteries in cynomolgus monkeys. J Am Coll Cardiol
1994;224:1757-61
32. Cushman M, et al, Effect of postmenopausal hormones on inflammation-sensitive proteins: the PEPI Study.
Circulation 1999 Aug 17; 100 (7):717-722
33. Adams MR, et al, MPA antagonizes inhibitory effects
of CEE on coronary artery atherosclerosis. Arterioscler
Thromb Vasc Biol. 1997 jan;17(1):217-21
34. Clarkson TB, Progestogens and Cardiovascular Disease. A Critical Review, J Reprod Med 1999 Feb;44 (2
suppl):180-4
35. Breast Cancer Development Demonstration Project,
JAMA Jan 2000, 283:485-491
36. Swedish record review for breast cancer. Cancer.
2003;97: 1387-1392
37. Monograph-Lifetime Hormonal Management
9/2001-USC School of Medicine
38. Lignieres BD, et al, Combined hormone replacement
therapy and risk of breast cancer in a French cohort
study of 3175 women. Climacteric 2002;5:332-340
SPRING 2008
39. Hofserh LJ, et al, HRT with estrogen or with estrogen
and MPA is associated with epithelial proliferation
in normal postmenopausal breast, J Clin Endocrinol
Metab1999;84:4559-65
40. J Natl Cancer Inst 92(4): 328-332,2000- adding
progestin increased breast cancer 29%
41. J Clin Oncology Vol 17, Issue 6, 1999; 1680- 9 studies of HRT in breast ca patients
42. J CLin Oncology Vol 19, Issue 8, 2001:2357-63
43. British J Cancer 1996; 73:1552-5-P decreases breast
proliferation
44. Chang Kj, et al, Influences of percutaneous administration of estradiol and progesterone on human
breast epithelial cell cycle in vivo. Fertil Steril
1995;63:785-791
45. Cowan LD, Gordia L. Breast cancer incidence in
women with a history of progesterone deficiency.
Am J Epidemiol. 1981 Aug;114(2):209-17
MISC
46. Lemon HM, Estriol prevention of mammary carcinoma induced by 7,12-dimethylbenzanthracene and
procarbazine.Cancer Res. 1975 May;35(5):1341-53.
47. Lemon HM, Reduced Estriol excretion in patients
with breast cancer prior to endocrine therapy, JAMA
1966, 196:1128-1136
48. Lemon HM, Pathophysiological considerations in the
treatment of menopausal patients with estrogens: The
role of oetriol in the prevention of mammary cancer.
Acta Endocrinol Suppl (Copenh) 1980;233:17-27
49. Lauritzen C, Clinical investigations of a long-acting
oestriol (polyoestriol phosphate).Acta Endocrinol
(Copenh). 1961 Sep;38:73-87
50. London, RS, Endocrine parameters and alpha-tocopherol therapy in patients with mammary dysplasia.
Cancer Res 1981. 41:3811-3813
51. De Kleijn MJ, et al, Endogenous Estrogen exposure and cardiovascular mortality risk in postmenopausal women. Am J Epidemiol 2002 Feb
15;155(4):339-345
52. Komesaroff PA, et al, A novel nongenomic action of
estrogen on the cardiovascular system. J Clin Endocrinol Metab 1998;83:2313-2316
53. Majoie H, et al, Effects of transdermal and oral
postmenopausal hormone therapy on vascular function: a RCT in healthy postmenopausal women.
Menopause 2005;12:526-535
54. Vitale C, et al, Interleukin-6 and flow mediated dilation as markers of increasing vascular inflammation
in women receiving hormone therapy. Menopause
2005;12:552-558
55. Vongpatanasin W, et al, Transdermal estrogen
replacement therapy decreases sympathetic activity in postmenopausal women. Circulation
2001:103:2903-2908
56. Dubey RK, et al, Clinically used estrogen differentially inhibit human aortic smooth muscle cell growth
and mitogen activated protein kinase activity. Arterioscler Thromb vasc Biol 2000;20:964-972
57. Affinito P, et al, Effects of hormonal replacement
therapy in postmenopausal hypertensive patients.
Maturitas 2001 Oct 31;40(1):75-83
58. Modena MG, et al, Double blind randomized placebo
controlled study of transdermal estrogen replacement
therapy on hypertensive postmenopausal women. Am
J Hypertens 1999;12:1000-1008
59. Seely EW, et al, Estradiol with or without progesterone and ambulatory blood pressure, Hypertension
1999 May;33(5):1190-4
60. Lindoff C, et al, Transdermal estrogen replacement therapy: beneficial effects on hemostatic risk
factors for cardiovascular disease. Maturitas 1996
May;24(1-2):43-50-2 years
61. Chen FP, et al, Comparison of transdermal and
oral estrogen-progestin replacement therapy: effects
risk factors cardiovascular Menopause 2001 SepOct;8(5):347-52-1 year
62. Scarabin PY, et al, Effects of oral and transdermal
estrogen/progesterone regimens on blood coagulation
SPRING 2008 and fibrinolysis in postmenopausal women. A Randomized Controlled Trial. Arterioscler Thromb Vasc Biol
1997 Nov;17(11):3071-8
63. Christian RC, et al, Estrogen status correlates
with the calcium content of coronary atherosclerotic plaques in women. J Clin Endocrinol metab
2002;87:1062-1067
64. Barrett-Connor, et al, Hormone therapy and coronary
artery calcification in asymptomatic postmenopausal
women: the Rancho Bernardo Study. Menopause
2005;12:40-48
65. Pelzer T, Estrogen Effects on the Heart, Mol Cell
Biochem.1996 Jul-Aug;160-161:307-13
66. Herrington DM, et al, for the HERS study group. Statin therapy, cardiovascular events, and total mortality
in the HERS. Circulation 2002; 105:2962-2967.
67. Grady D, et al, Cardiovascular disease outcomes
during 6.8 years of hormone therapy. Heart and Estrogen/Progestin Replacement Study Follow-up (HERS
II). JAMA 2002;288:49-57
68. Hsia J, et al, Peripheral artery disease in randomized trial of estrogen with progestin in women
with coronary artery disease: HERS. Circulation
2000;102:2228-2232
69. Simon JA, et al, Postmenopausal hormone therapy and the risk of stroke: HERS. Circulation
2001;103:638-642
70. Nurses Health Study. Grodstein F, et al, A prospective,
observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease.
Ann Intern Med 2000;133:933-941
Maturitas 2000;36:155-164
86. Loprinzi CL, et al, Venlafaxine in management
of hot flushes in survivors of breast cancer. Lancet
2000.356:2059
87. Loprinzi CL, et al, Phase III evaluation of fluoxitine for treatment of hot flushes. J Clin Onc
2002;20:1578-1583
88. Prior JC, Progesterone as a bone trophic hormone.
Endocrin Rev 1990;11(2):386-398
89. Hirvonen E, et al, Transdermal oestradiol gel in the
treatment of the climacterium: a comparison with oral
therapy. Br J Obstet Gynecol 1997 Nov;104 Suppl
16:19-25
90. Prestwood KM, et al, The effect of low dose micronized 17ss-estradiol on bone turnover in older women:
A randomized, double blind, placebo controlled study.
J Clin Endocrinol Metab 2000;85:4462-49
91. Ettinger B, et al, Effects of ultralow-dose transdermal
estradiol on bone mineral density: a randomized clinical trial. Obstet Gynecol. 2004 Sep;104(3):443-51.
92. Miller BE, et al, Sublingual administration of micronized estradiol and progesterone, with and without
micronized testosterone: effect on biochemical markers of bone metabolism and bone mineral density.
Menopause. 2000 Sep-Oct;7(5):318-26.
93. Raisz LG, et al, Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resportion in
postmenopausal women. J Clin Endocrinol Metab
1996;81:37-41
71. Grodstein F, et al, Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. NEJM
1996; 335:453-461
94. Watts NB, et al, Comparison of oral estrogens and
estrogens and androgen on bone mineral density,
menopausal symptoms and lipidm profiles in surgical
menopause. Obstet Gynecol 1995;85:529-537,668
72. Lobo Rogelio (Pres Menopausal Society) Review of
4 randomized prospective trials with 7,000 women of
mean age 53 on hormone HRT.
95. American Gastroenterological Association Sept 24,
1998. Analysis Indicates estrogen may reduce colorectal cancer risk in postmenopausal women
73. Colditz GA, et al, The use of estrogens and progestins and the risk of breast cancer in postmenopausal
women.N Engl J Med. 1995 Jun 15;332(24):1589-93.
96. Csizmadi I, et al, The effects of transdermal and oral
estrogen replacement therapy on colorectal cancer
risk in postmenopausal women. Br J Cancer. 2004 Jan
12;90(1):76-81
74. Bagger YZ, et al, Early postmenopausal hormone
therapy may prevent cognitive impairment later in life
.Menopause 2005;12:12-17
75. Family Practice News, Feb 1,2004:69, JAMA
2004;291:3005-07
76. Caches County Study Memory Study. Zandi PP, et
al, Hormone replacement therapy and the incidence of Alzheimer’s disease in older women. JAMA
2002;288:2123-29, similar finding in two other major
studies
77. Tang MX, et al, Effect of oestrogen during menopause
on risk and age of onset of Alzheimer’s disease. Lancet
1996 Aug 17;348(9025):429-32
78. Grady D, et al. The effect of postmenopausal hormone
therapy on cognitive function: HERS. Am J Med 2002;
113:543-548
79. Espeland MA, et al, WHIMS. CEE and global cognitive
function in postmenopausal women: WHIMS. JAMA
2004;291:2959-2968, 2947-2958
80. Rapp SR, et al, WHIMS. Effect of estrogen plus progestin on global cognitive function in postmenopausal
women. JAMA 2003;289:2663-2672, 2651-2662
81. Mulnard RA, et al, Estrogen replacement therapy for
treatment of mild to moderate Alzheimer’s disease: a
randomized controlled trial. Alzheimer’s Disease Cooperative Study. JAMA 2000 Feb 23;283(8):1007-15
82. Henderson VW, et al, Estrogen for Alzheimer’s
Disease in women: randomized, double-blind,
placebo controlled trial. Neurology 2000 Jan
25;54(2):295-301
83. Salmi P, et al, Evidence for the functional interactions between 5HT-1A and 5HT-2A receptors in
thermoregulatory mechanisms. Pharmacol Toxicol
1998;82:122-127
84. Stearns V, et al, Hot flushes. Lancet
2002;360:1851-1861
97. NAMS Position Statement on testosterone therapy
in postmenopausal women. Menopause 2005; 12
(5):497-511
98. Shifren JL, et al, Transdermal Testosterone treatment
in women with impaired sexual function after oopherectomy. NEJM 2000;343:682-688
99. Fitzpatrick LA, ed. Androgen therapy for Women:
The Evidence, OBG Management May 2004 (Suppl)
100. Tzingounis VA. Estriol in menopause. JAMA 1978.
239: 1638-1641
101. Raz R, et al, A controlled trial of intravaginal estriol
in postmenopausal women with recurrent urinary
tract infections, NEJM, 1993;329(11),753-6
102. Yoshimura T, et al, Short term oral estriol treatment
restores normal premenopausal vaginal flora to elderly
women. Maturitas 2001, Sep 28;39(3):253-7
103. Koloszar S,et al, Tretament of climacteric urogenital
disorders with an estriol-containing ointment. Orv
Hetil 1995 Feb 12; 136(7):343-5
104. Sonni R, et al, Presenile and senile vulvovaginitis.
Topical hormone treatment with estriol. Minerva
Ginecol 1991 Apr;43(4):177-9
105. Kochlio OR, et al, Effectiveness of estriol depot
vaginal suppositories in postmenopasusal women with
urogenital climacteric manifestations. Gynakol Geburtshlfliche Rundsch 1992;32(2):88-91
106. Suckling J, et al, Local estrogen for vaginal atrophy
in postmenopausal women. Cochrane Database Syst
review.2003;(4):CD001500
107. Pati S, Bioidentical Hormone Therapy in Women,
European Journal of Anti-Aging Medicine, 2006
108. Cirigliano M, Bioidentical Hormone Therapy: A
Review of the Evidence, Journal of Women’s Health,
Vol16, (5), 2007,600-631
85. Berendsen HH, The role of serotonin in hot flushes.
❘ 21
CorpA
BUYERS Guide
Aesthetic Medical Treatments
Ageless Aesthetic Institute
P.O. Box 20642
Columbus , OH 43220
USA
800-420-2689
www.agelessaestheticinstitute.com
Alma Lasers
485 Half Day Road Suite 100
Buffalo Grove, IL 60089
USA
Kintech USA
14111 Freeway Dr. #205
Santa Fe Springs, CA.
90670
USA
224-377-2000
www.almalasers.com
Kintech USA offers professional
and retail lines of Enspri skin care
products addressing two key components to healthy skin, abundant
collagen levels and ample hydration. Enspri’s 100% Collagen 5000
and Activator Gel create an effective collagen facial mask treatment
and the Ceramide Skin Essence
is specially designed to optimize
dermal hydration.
562-802-1760
www.enspri.biz
Arasys Perfector, LLC The vision of naturally enhancing
AESTHETIC MEDICAL TREATMENTS / Alternative Therapies
7773 Waikapu Loop
Honolulu, HI 96825
USA
rejuvenation and healthy anti-aging
drives our commitment to push
the boundaries of science into
new discoveries to deliver the best
next generation solutions to Facial
Rejuvenation and Body Sculpting.
At Arasys Perfector, LLC we challenge the bounds of science and
creativity to deliver on tomorrow’s
capability.
808-395-0656
www.arasysperfector.com
Please see ad on pages 14-15 (SH)
Beautiful Image LLC
PO Box 771328
Ocala, FL 34477
USA
352-804-6751
Results Rx, LLC
3715 Northside Pkwy, Bldg 200, # 200 877-367-7975
Atlanta, GA 30327
USA Rofil Medical Netherlands B.V.
Heusing 16
Breda, 4817 ZB
The Netherlands
47733 Fremont Blvd.
Fremont, CA 94538
USA
800-532-1064
www. conbio.com
560 Bradley Pkwy
Blauvelt, NY 10913
USA
Innovative Directions In Health
4005 W 65th Street, suite 212
Edina, MN 55435
USA
Ion Magnum, LLC
7773 Waikapu Loop
Honolulu, HI 96825
USA
952-922-2345
www.idinhealth.com
Ion Magnum is based on an advanced version of the Pacemaker
technology, designed to resonate
the electrically excitable neurons
firing during regular strenuous exercise. Apart from muscle building,
neuronal signal restoration and enhancement, the Ion Magnum signal
offers a significant increase in blood
circulation and lymphatic drainage
for increased immune efficiency.
808-395-0656
www.ionmagnum.com
Iredale Mineral Cosmetics
28 Church Street
Great Barrington, MA 01226
USA
800-762-1132
www.janeiredale.com
+31765315670
www.rofil.com
Alternative Therapies
American
Biosciences Inc.
Hoya ConBio
www.resultsrx.com
www.cosmedix.com
Avé - Avemar – FWGE (Fermented
Wheat Germ Extract) Avé, winner
of the NutrAward for “Best New
Product” and subject of over 20
peer-reviewed research publications, is the first dietary supplement
available in the U.S. to contain the
nutrient, Avemar®. One daily use
of Avé is shown to support healthy
cell metabolic regulation and promote immune system modulation
resulting in a healthy cellular and
humoral (Th1/Th2) immune system
balance. For research, contact
American BioSciences, Inc, at
(888)884-7770
845-727-0800
www.americanbiosciences.com
Please see ad on page 101 (SH)
7773 Waikapu Loop
Honolulu, HI 96825
USA
capability.
808-395-0656
BG= Buyers Guide, SH= Show Guide
22 ❘
SPRING 2008
CorpAd_A4M_022808:Layout 1
2/28/08
12:09 PM
Page 1
Better Tests. Better Health.
Better Life.
Genova Diagnostics
provides clinical laboratory
testing for all your specialty
lab needs. Our products cross
a broad spectrum of areas
including hormonal,
nutritional, genomic,
gastrointestinal, and immune
tests to help progressive
clinicians treat patients
interested in wellness for
longer, healthier lives.
Our service doesn’t stop there;
Genova Diagnostics’ medical
education department provides
physicians with the latest
clinical information for optimal
treatment options. In the
laboratory, we maintain the
highest industry standards to
ensure that your patients
receive accurate, timely results.
Get to know the leader!
See us at Booth 411
Visit us at
www.GDX.net
or call us at
800-522-4762
BioMed Wellness, LLC
BUYERS Guide
900 E. Atlantic Ave. Suite #9
Delray Beach, FL 33483
USA
561-279-2524
www.biomedwellness.com
Cell Science Systems-Alcat Laboratory
1239 East Newport Center Dr., #101954-426-2304
Deerfield Beach, FL 33442
www.alcat.com
USA
63 Via Pico Plaza #123
San Clemente, CA 92672
USA
949-369-9600
www.chocolateheals.com
Associations / Education
American Academy of Cosmetic Physicians
Clear Mind Center®
2101 Business Center Drive, #100 949-222-1020
Irvine, CA 92612
714-609-7140
USA
www.clearmindcenter.com
8000 South Kolb Rd., Ste.101
Tucom, AZ 85706
USA
930 Old Harmony Rd., Suite A
Newark, DE 19713
USA
302-709-0408
www.litecure.com
ApothéCure, Inc.
Novus Optimum Lab
P.O. Box 640588
San Francisco, CA 94164
USA
Oxy Health, LLC
10719 Norwalk Blvd.
Santa Fe Springs, CA
90670
USA
520-574-1050
Compounding Pharmacies
LiteCure, LlC
Associations / Education / Compounding Pharmacies
Xocai
415-986-8991 / 888-499-9100
www.novusoptimum.com
OxyHealth has changed how the
medical industry looks at hyperbaric medicine and paved the way
for the modern hyperbaric practice.
With over 6,000 portable and steel
chambers in service today, OxyHealth has refined “industry standards” and achieved global status.
One chamber at a time, OxyHealth
makes hyperbarics come to you.
562-906-8888
www.oxyhealth.com
QuantumStim.com/The MRS 2000
7800 E. Orchard Road #120
303-503-3420
Greenwood Village, CO 80111 www.quantumstim.com
USA
Sunlight Saunas
7373 W. 107th Street
Overland Park , KS 66212
USA
4001 McEwen Road, Suite 100
Dallas, TX 75244
USA
Bellevue Pharmacy Solutions
10345 S. Brentwood Blvd., Ste.102314-727-8787
St. Louis, MO 63117
www.bpharmacysolutions.com
USA
College Pharmacy
3505 Austin Bluffs Pkwy
Colorado Springs, CO 80918
USA
Live Well
Drugstore
3516 Enterprise Way # 7
Green Cove Springs,FL
32043
USA
877-292-0020
www.sunlightsaunas.com
904-531-3030
www.livewelldrugstore.com
232 Avenida Fabricante, Ste. 110 949-485-5427
www.vibrahs.com
USA
12685 South 125 East
Draper, UT 84020
USA
877-656-4553
www.detoxamin.com
800-888-9358 ext. 182
www.collegepharmacy.com
Live Well Drugstore is a state of the
art compounding pharmacy. Live
Well Drugstore specializes in the
compounding of natural bioidentical hormones with over 100 years of
compounding pharmacy experience in our staff. We offer home delivery of prescriptions as part of our
comprehensive customer service .
We are a full scale retail pharmacy
and can supply a complete line
of traditional medications as well.
At Livewell Drugstore we strive for
excellence in all that we do!
Vibration Health Solutions, Inc.
World Health Products, LLC
800-969-6601
www.apothecure.com
MedQuest Pharmacy
669 W. 900 North
North Salt Lake, UT 84054
USA
888-222-2956
www.mqrx.com
24 ❘
SPRING 2008
800-279-5708
www.womensinternational.com
Liquid Ice CosMedicals AG
Zugerbergstrasse 86
CH- 6314 Unterägeri
Switzerland
Regeron, Inc.
B403 BIC, Hi-Tech Venture
Town
198-53 Hupyung-Dong
Chunchon, Kangwon-Do
200-161
South Korea
+41 41 750 89 89
www.liquidice.com
BUYERS Guide
2 Marsh Court
Madison, WI 53718
USA
For over 22 years Women’s International Pharmacy has specialized in
custom compounded bioidentical
hormone prescriptions for men and
women. Women’s International Pharmacy is a trusted source for practitioners and their patients. Our pharmacy provides quality compounded
prescriptions, excellent customer
service, consulting services, and
upon request, educational information on hormone therapies.
Develops and produces reverseaging biotech products - especially
proteins for cosmetic and pharmaceutical applications. The world-first
developer of cosmetic human
growth hormone and discoverer
of its authentic cosmeceutical efficacies such as wrinkle repair and
firming on the face; and hair growth
and hair follicle rejuvenation on the
head.
+82-33-258-6262
www.regeron.com
Computer / EMR
Computer / EMR / Cosmeceuticals / Dental /
Dermatology / Diagnostic Service / Lab
Women’s
International
Pharmacy
Canfield Imaging Systems
253 Passaic Avenue
Fairfield, NJ 07004
USA
800-815-4330
www.canfieldsci.com
Mack Software Solutions, Inc.
3608 Preston Rd, Suite 225
Plano, TX 75093
USA
MD-Ware Software
1788 Drew Rd, Suite A
Mississauga, ON L5S 1L7
Canada
Vitivia
140 East Bay Street, suite C
Charleston, SC 29401
USA
888-975-4848
www.vitivia.com
800-450-6225
www.macksoftware.com
Dental / Dermatology
800-798-6199
www.mdware.com
28 Church Street
USA
800-762-1132
www.janeiredale.com
Prime Clinical Systems, Inc.
3675 E. Huntington Drive, Suite A 626-449-1705
Pasadena, CA 91107
www.primeclinical.com
USA
Cosmeceuticals
Kintech USA
14111 Freeway Dr. #205
Santa Fe Springs, CA.
90670
USA
Aminocare Products, L.P.
9432 Old Katy Rd Suite 200
Houston, TX 77055
USA
800-856-8006
www.aminocare.com
Kintech USA offers professional
and retail lines of Enspri skin care
products addressing two key components to healthy skin, abundant
collagen levels and ample hydration. Enspri’s 100% Collagen 5000
and Activator Gel create an effective collagen facial mask treatment
and the Ceramide Skin Essence
is specially designed to optimize
dermal hydration.
562-802-1760
www.enspri.biz
CosMedical Technologies
3961 SW 47th Avenue
Davie, FL 33314
800-275-3627 x 116
www.cosmedicaltechnologies.com
USA
28 Church Street
USA
800-762-1132
www.janeiredale.com
Jan Marini Skin Research
6951 Via Del Oro
San Jose. CA 95119
USA
800-347-2223
www.janmarini.com
PURIGENEX
1821 Wilshire Blvd Suite 300
Santa Monica, CA 90403
USA
877-787-4469
www.purigenex.com
Diagnostic Service / Laboratories
Access Medical Labs, Inc
2151 Alt. A1A Suite 1500
Jupiter, FL 33477
USA
561-745-1233
www.accessmedlab.com
❘ 25
BUYERS Guide
AGE DIAGNOSTIC
LABORATORIES
301 NE 51st Street
Boca Raton, FL 33431
USA
Age Diagnostic Laboratories is
dedicated to serving the needs of
Healthcare Professionals practicing anti-aging medicine and pride
ourselves on our ability to provide
clients with a comprehensive range
of patient-friendly test kits supported by the highest quality laboratory
services and unparalleled client
support.
877-983-7863
www.adltests.com
Please see ad on page 8-9 (SH)
Labrix Clinical Services, Inc.
619 Madison St #100
Oregon City, OR 97045
USA
877-656-9596
www.labrix.com
Meridian Valley Laboratories
801 SW 16th St., Suite 126
Renton, WA 98057
USA
425-271-8689
www.meridianvalleylab.com
Path Medical
Diagnostic Service / Laboratories / Hair Rejuvenation
304 Park Ave South
New York, NY 10010
USA
Biophysical
Corporation
3300 Duval Road
Austin, TX 78759
USA
Biophysical250 provides the most
comprehensive and advanced
assessment of personal health
ever developed by innovatively
analyzing blood-based biomarkers.
Founded in Austin, Texas in 2004,
Biophysical’s management and
advisory board include internationally renowned scientists and physicians who are leaders in biomarker
research. For more information
visit www.biophysicalcorp.com or
1-800-532-7092.
512-623-4900
www.biophysicalcorp.com
888-304-PATH
www.pathmed.com
Rhein Consulting Laboratories
4475 SW Scholls Ferry Rd #101
Portland, OR 97225
USA
503-292-1988
www.rheinlabs.com
Sage Medical Laboratory
1400 Hand Ave Ste L
Ormond Beach, FL 32174
USA
800-491-9511
www.sagemedlab.com
Spectracell Laboratories
10401 Town Park Dr.
Houston, TX 77072
USA
713-621-3101
www.spectracell.com
Diagnos-Techs Saliva Hormone Tests
6620 South 192nd Place, #J
Kent, WA 98032
USA
Genova
Diagnostics
63 Zillicoa Street
Asheville, NC 28801
USA
770-401-3853
www.DiagnosTechs.com
Headquartered in Asheville, N.C.,
Genova Diagnostics is a global
leader in functional laboratory
testing, pioneering innovative new
approaches to personalized medicine. With a commitment to the
highest standards, the internationally renowned lab offers comprehensive panels that facilitate
physician-patient communication
and development of a personalized
approach to optimal health.
800-522-4762
www.GDX.net
Please see ad on page 23 (BG)
KMI Diagnostics, Inc.
8201 Central Ave. NE, Ste.P
Minneapolis, MN 55432
USA
ZRT Laboratory
1815 NW 169th Place, Suite 5050 503-597-1926
Beaverton, OR 97006
www.salivatest.com
USA
Hair Rejuvenation
Amici 0.3 Corporation
321 W. Prospect Ave. Mount Prospect, IL 60056
USA
Regeron, Inc.
B403 BIC, Hi-Tech Venture
Town
198-53 Hupyung-Dong
Chunchon, Kangwon-Do
200-161
South Korea
763-780-2955
www.kmidiagnostics.com
KuraBiol Laboratories
4000 Ponce De Leon Blvd., Ste.470
Coral Gables, FL 33156
USA
305-670-0212
www.propharma.us
847-259-3600
www.amici03.com
Develops and produces reverseaging biotech products - especially
proteins for cosmetic and pharmaceutical applications. The world-first
developer of cosmetic human
growth hormone and discoverer
of its authentic cosmeceutical efficacies such as wrinkle repair and
firming on the face; and hair growth
and hair follicle rejuvenation on the
head.
+82-33-258-6262
www.regeron.com
Sunetics
4760 Pecos Road Suite 103
Las Vegas, NV 89121
USA
877- 777-8818
www.sunetics.com
26 ❘
SPRING 2008
BUYERS Guide
Holistic Medicines
American Biotech Labs
80 West Canyon Crest Rd.
Alpine, UT 84004
USA
136 Stutts Rd. #4
Mooresville, NC 28117
USA
Holistic Medicines / Hyperbaric / Oxygen Therapies /
Insurance / Finance / Practice Management / Marketing
PO Box 44514
Shreveport, LA
71134-4514
USA
801-756-1000
www.americanbiotechlabs.com
Acara MedSpas
500 East Main St. Suite 216
Branford, CT 06405
USA
Aqua Detox USA
AromaMD LLC
Insurance / Finance /
Practice Management / Marketing
704-662-9270
www.aquadetoxusa.com
Bankers Healthcare Group, Inc.
4875 Volunteer Road, Suite 100 800-990-8401
Southwest Ranches, FL 33330
www.bhg-inc.com
USA
AROMA MD, LLC
•Physician formulated organic,
medical aromatherapy •Flexible
dosing Internal/Topical •Clinically
studied •Organic •Free of sugar,
dye, alcohol, dairy, nuts
Supporting: Aroma Psychiatric,
Focus, Get Up, Study Buddy, Sweet
Sleep; Aroma Pediatric: Tummy
Cuddles; Aroma Rehab: Body
Relief; Aroma Biotic:Aroma Aid,
Ha Choo
318-869-3883
www.aromamd.net
Beacon Processing Solutions
1060 Woodcock Rd.
Orlando, FL 32803
USA
94 Hangar Way
Watsonville, CA 95076
USA
800-662-2544 x1
www.nordicnaturals.com
1499 W Palmetto Park Rd, Suite 405
USA
1700 E. Beltline, NE, Suite 130
Grand Rapids, MI 49525
USA
888-625-8705
www.bodylogicmd.com
800.968.5000
www.chaseindustries.com
Doctors Aesthetic Network
Ondamed Inc.
80 Waterview Terrace
New Windsor, NY 12553
USA
845-496-6673
www.ondamed.net
2118 N. Tyler, Bldg. A
Wichita, KS 67212
USA
Durocher Enterprises
Pleomorphic Sanum
5170 W. Phelps Road
Glendale, AZ 85306
USA
602-439-7977
www.pleosanum.com
Hyperbaric / Oxygen Therapies
10719 Norwalk Blvd.
Santa Fe Springs, CA
90670
USA
877-665-6798
www.Beaconprocessing.com
BodyLogicMD
Chase Industries
Nordic Naturals
Oxy Health, LLC
203-488-0028
www.AcaraMedSpas.com
OxyHealth has changed how the
medical industry looks at hyperbaric medicine and paved the way
for the modern hyperbaric practice.
With over 6,000 portable and steel
chambers in service today, OxyHealth has refined “industry standards” and achieved global status.
One chamber at a time, OxyHealth
makes hyperbarics come to you.
562-906-8888
www.oxyhealth.com
303-503-3420
USA
6836 Beecaves Rd.
Austin, TX 78746
USA
316-729-5620
877-596-0243
www.durocherenterprises.com
LocateADoc.com / Mojo Interactive
1060 Woodcock Rd.
Orlando, FL 32803
USA
Plurotech Inc.
2700 S. River Road, Ste. 100
Des Plaines, IL 60018
USA
877-665-6798
www.LocateADoc.com
866-999-8555
www.plurotech.com
303-503-3420
USA
Smile Reminder
210 N 1200 E Ste 150
Lehi, UT 84043
USA
866-605-6867
www.smilereminder.com
28 ❘
SPRING 2008
www.ZoomDazzle.com will give
you the most advanced, proven
medical marketing systems,
strategies, tactics & tools for you to
quickly and easily integrate and
automate your online and offline
marketing to generate YOU the
most predictable and continuous
flow of qualified prospects, patients
& referrals so YOU can future-proof
your practice, dominate your
market and continue to do what
you do good.
Canfield Imaging
Systems
253 Passaic Avenue
Fairfield, NJ 07004
USA
The Reveal Imager from Canfield
Imaging Systems is designed to take
high quality facial photographs in
almost any environment. This new
system captures images of surface
and sub-surface skin features and
will photograph front, left, and right
views. It is ideal for spas, medical spas and traditional medical
practices.
BUYERS Guide
www.ZoomDazzle.com
2000 Banks Rd, Suite 214b
Margate, FL 33063
USA
800-815-4330
www.canfieldsci.com
1-800-399-9781
www.ZoomDazzle.com Please see
ad on page 177 (SH)
2021 Commerce Dr.
McKinney, TX 75069
USA
Med Spa / Equipment
HydroMassage
7773 Waikapu Loop
Honolulu, HI 96825
USA
capability.
808-395-0656
15395 Roosevelt Blvd
Clearwater, FL 33760
USA
Ion Magnum, LLC
7773 Waikapu Loop
Honolulu, HI 96825
USA
888-242-0571
www.Erchonia.com
Med Spa / Equipment
Erchonia Medical
727-536-5566
www.hydromassage.com
808-395-0656
www.ionmagnum.com
Astron Clinica
1979 Marcus Avenue, Suite 210 516-622-2363
Lake Success, NY 11042
www.astronclinica.com
USA
Ondamed Inc.
USA
Canfield Imaging
Systems
253 Passaic Avenue
Fairfield, NJ 07004
USA
Canfield’s VISIA® with RBX™
Technology provides extraordinary
detection, visualization and analysis
of subsurface melanin (brown) and
vascular (red) conditions. Canfield’s proprietary RBX color-space
processing separates red and
brown skin components, enabling
precision treatment planning and
dynamic patient consultations. for
laser therapies, photo rejuvenation, microdermabrasion, chemical
peels, cosmeceuticals and acne
treatment.
800-815-4330
www.canfieldsci.com
Sunlight Saunas
7373 W. 107th Street
Overland Park , KS 66212
USA
845-496-6673
www.ondamed.net
877-292-0020
www.sunlightsaunas.com
Synergie By Dynatronics
7030 Park Centre Dr
Salt Lake City, UT 84121
USA
801-568-7000
www.dynatronics.com
❘ 29
BUYERS Guide
Vibration Health
Solutions, Inc.
232 Avenida Fabricante,
Ste. 110
USA
Degenerative disease and accelerated aging have been attributed
to insufficient cellular stimulation.
As living cells struggle with poor
nutrition, low oxygen levels, environmental toxins, and stagnation of
lymphatic fluids, disease conditions
develop and accelerate again and
shorten lifespan. The solution has
arrived with The Evolution™-whole
body vibration at its finest!
949-485-5427
www.vibrahs.com
AA Advanced Technology Inc.
6422 W. Belmont Ave.
Chicago, IL 60634
USA
Body Care Resort, Inc.
1815 W. 205th, Ste. 106
Torrance, CA 90501
USA
Colonic.net
10911 West Avenue
San Antonio, TX 78213
USA
Advanced Aesthetic Concepts
307 W. 7th Street, Suite 220
Ft. Worth , TX 76102
USA
1180 Walnut Ave
Chula Vista, CA 91911
USA
800-337-0745
www.fromstarttoperfection.com
Serving Integrative Medicine for 30
years with Science Based Nutritional
Supplements... well tolerated by the
most sensitive individuals – Dioxychlor, Inf-zyme, Oxy-5000, Brain
Power, GPC, Taurine, Hepa Trope,
NeuroRecovery, etc. Bradford
Variable Projection Microscope
with computerized storage and
imaging. Training in comprehensive
functional assessments by Dr. Robert
Bradford in your office.
15693 83 Lane North
Loxahatchee, FL 33470
USA
561-784-0599
www.dermawaveusa.com
Eidam Diagnostics Corporation
100 - 13777 Commerce Parkway 604-304-6006
Richmond, BC V6V 2X3
www.eidam.com
Canada
Ellman International
3333 Royal Ave.
Oceanside, NY 11572
USA
800-835-5355
www.ellman.com
619-429-8200 / 800-227-4473
www.AmericanBioLogics.com
30th Anniversary
Ion Magnum, LLC
7773 Waikapu Loop
Honolulu, HI 96825
USA
561-742-4401
www.cryo-surgical.com
773-481-2568
www.MesoDerm.com
Dermawave
American
Biologics
210-308-8888
www.colonic.net
Cryosurgical Concepts
200 Knuth Road, Suite 204
Boynton Beach, FL 33436
USA
310-782-3992
www.bodycareonline.com
capability.
7773 Waikapu Loop
Honolulu, HI 96825
USA
808-395-0656
www.ionmagnum.com
808-395-0656
BioMeridian International
12411 S 265 W Suite F
Draper, UT 84020
USA
888-224-2337
www.biomeridian.com
KORR Medical Technologies
2463 S 3850 W Building 200
Salt Lake City, UT 84120
USA
800-483-2080
www.korr.com
30 ❘
SPRING 2008
1 6 T H A N N UA L WO R L D
CONGRESS ON ANTI-AGING
M E D I C I N E A N D R E G E N E R AT I V E
BIOMEDIC AL TECHNOLOGIES
JULY 17-19, 2008
WASHINGTON D.C.
SPORTS
REHAB
COSMETIC
SURGERY
AESTHETIC LASER
PROCEDURES
IN-OFFICE
DIAGNOSTIC
IMAGING
BIO-IDENTICAL
HORMONE
THERAPY
LABORATORY
MEDICINE /
BIOMARKERS OF AGING
MEDICAL
SPAS
MEDICAL WEIGHT LOSS
&
NUTRITION
100+ Topics Including:
s"IO)DENTICAL(ORMONE2EPLACEMENT
s3TEM#ELLS'ENE4HERAPY
s/BESITY$RUGSAND-ETABOLIC-EDICINE
s !ESTHETIC-EDICINE"OTOXAND&ILLERS
s$.!2EPAIR-ECHANISMS
Call Toll Free to Register
(USA 1.800.558.1267)
American Academy of Anti-Aging Medicine
1510 West Montana Street Chicago, IL 60614, USA
Dr. Ronald Klatz
MD, DO
President, A4M
Dr. Robert Goldman
MD, PhD, DO, FAASP
Chairman of the Board, A4M
Toll Free (USA)
1.800.558.1267
Registration Information 1.773.528.1000
W W W. W O R L D H E A LT H . N E T
BUYERS Guide
LD Technology
100 North Biscayne Blvd.
#500.
Miami, FL. Zip 33132
USA
The EIS System is the only commercially available unit utilizing a
Direct Current allowing in vivo for
the analysis of the physiological
parameters within the tissues of the
organs via the interstitial fluid.
The process provides repeatable
data with no operator bias.
Developed by MD’s, physicists,
mathematicians & statisticians LD
Technology is leading the field in
bio-sensor technology.
Living Younger Preventive-Aging Medicine &
Business System
10371 N. Oracle Road, Suite 205 520-229-1900
Oro Valley, AZ 85737
www.LivingYoungerUSA
Preventive-Aging.com
MedEsthetics
Magazine/Creative
Age Publications
7628 Densmore Avenue
Van Nuys, CA 91406-204
USA
305-505-5233
www.ldteck.com
800-442-5667
www.medestheticsmagazine.com
Medical Equipment / Supplies / Mesotherapy / Hormone Therapies / MISC
Med-Hot Thermal Imaging
315 Doris Drive
Lakeland, FL 33813-2083
USA
Take your medical aesthetic practice or medspa to a whole new
level. Sign up for a free subscription to MedEsthetics, the business
magazine for physicians offering
aesthetic services. Each issue features cutting-edge equipment and
products, strategic management
tools, marketing tips, industry news
and more.
863-646-1599
www.med-hot.com
Mesotherapy / Hormone Therapies
Ondamed Inc.
USA
Pharmanex
9021 Greensboro
Las Vegas, NV 89134
USA
Power Plate
400 Skokie Blvd, Suite 105
Northbrook, IL 60062
USA
Sciton
925 Commercial Street
Palo Alto, CA, 94303
USA
Syneron
3 Goodyear Unit A
Irvine, CA 92618
USA
Viora Inc
30 Montgomery St, Suite 660 Jersey City, NJ 07302
USA
845-496-6673
www.ondamed.net
AA Advanced Technology Inc.
702-363-5343
Live Well MD
1996 Kingsley Ave.
Orange Park, FL 32073
USA
847.509.6000 option 5
650-493-9155
www.sciton.com
949-716-6670
www.syneron.com
927 Leverenz
Naperville, IL 60565
USA
773-481-2568
www.MesoDerm.com
Live Well MD uses compounded BioIdentical Hormone Therapy to treat
Menopause, Andropause, Hypothyroidism, and many other hormonal
imbalances. Our success is founded
on being proactive, providing
education, and complete follow
up of our clients. We also have a
physician component that allows interested physicians to learn the art
of BHRT. We are parterned with Live
Well Drugstore for compounded
hormones and traditional medications. Increase your revenue stream
and learn how to Live Well Again!
904-276-5700
www.livewellmd.com
Natural Living, Inc.
4012 S Rainbow Blvd., Ste.K-201. 702-430-8771
Las Vegas, NV 89103
www.estra325.com
USA
Regeron, Inc.
201-332 4100
www.vioramed.com
Medical Publications / Directories
Elsevier
6422 W. Belmont Ave.
Chicago, IL 60634
USA
630-420-0756
www.elsevier.com
B403 BIC, Hi-Tech Venture Town +82-33-258-6262
198-53 Hupyung-Dong
www.regeron.com
Chunchon, Kangwon-Do 200-161
South Korea
Miscellaneous
The BioMat Company
3708 NE 109th Ave., Apt.BB10
Vancouver, WA 98682
USA
360-256-7577
www.thebiomatcompany.com
32 ❘
SPRING 2008
Caregen Co., Ltd.
690-3, Caregen Bldg. Geumjeong-dong, Gunpo-si,
Gyeonggi-do, 435-862
800-800-3405
www.calmoseptineointment.com
30th Anniversary
2840 West Bay Drive, Ste. 111
Belleaire Bluffs, FL 33770
USA
Homefirst® Health Services
LIFE Ionizers
2335 Camino Vida Robles # B
Carlsbad, CA 92009
USA
Perque LLC
14 Pidgeon Hill Dr., Ste.180
Sterling, VA 20165
USA
1180 Walnut Ave
Chula Vista, CA 91911
USA
+82-31-452-3867
www.caregen.co.kr
South Korea
ENVi International
2000 Golf Road
Rolling Meadows, IL 60008
USA
American
Biologics
866-395-3311
www.homefirst.com
760-431-8047
www.LIFEIonizers.com
Bioenergy, Inc.
13840 Johnson St, NE
Minneapolis, MN 55304
USA
BioPharma
Scientific
9010 Kenemar Suite 101
San Diego, CA 92121
USA
703-450-2990
www.perque.com
Progressive Solutions Pharmacy
585 West 9400 South
Sandy, UT 84070
USA
S-Force / Seriesse
98 S. Federal Hwy.
USA
801-255-4567
PO Box 1849
Fort Collins, CO 80522
USA
619-429-8200 / 800-227-4473
www.AmericanBioLogics.com
866-267-8253
www.bioenergy.com
“Just like vitamins and minerals, the
phytonutrients from high ORAC*,
organic fruits and vegetables in
NanoGreens10**, and the zoonutrients from undenatured whey and
colostrum peptides in NanoProPRP***, are most beneficial when
taken together.” Ron Rothenberg,
M.D., Founder, California Health
Span Institute *8,256 / serving **
product used in hypertension
study*** undenatured. Available
thru health professionals only!
877-772-4362
www.nanogreens.com/free
561-620-4798
www.laainstitute.com
Biotivia LLC
Vescent, Inc.
Serving Integrative Medicine for 30
years with Science Based Nutritional
Supplements... well tolerated by the
most sensitive individuals – Dioxychlor, Inf-zyme, Oxy-5000, Brain
Power, GPC, Taurine, Hepa Trope,
NeuroRecovery, etc. Bradford
Variable Projection Microscope
with computerized storage and
imaging. Training in comprehensive
functional assessments by Dr. Robert
Bradford in your office.
BUYERS Guide
16602 Burke Lane
Huntington Beach, CA 92647
USA
Miscellaneous / Nutraceuticals
Calmoseptine, Inc.
970-493-6909
www.vescent.com
1 River Place, Ste. 1001
New York, NY 10036
USA
Biotivia pioneered the concept
of Evidence Based bioceuticals
designed to address specific Life
Style related health issues. Offering
the world’s best selling, Consumer
Lab approved resveratrol longevity
supplements.
646-862-0095
www.biotivia.com
Nutraceuticals
Amalaki Plus, Ltd (Zrii Distributor)
936 W. 8th St.
Anderson, IN 46016
USA
317-222-1481
www.zpros3.myzrii.com
AMARC Enterprises (Poly-MVA)
1339 Broadway
San Diego, CA 92021
USA
619-447-6500
www.polymva.com
Capsugel
535 North Emerald Road
Greenwood, SC 29646
USA
888-783-6361
www.capsugel.com
❘ 33
BUYERS Guide
Core Naturals Salba
5703 Red Bug Lake Rd., #190
Winter Springs, FL 32708
USA
Salba RX- “Nature’s Perfect Whole
Food is the richest source of
Omega 3’s and Fiber, and gram
for gram packs six(6) times more
calcium than milk, fifteen(15) times
more magnesium than broccoli,
and three(3) times more antioxidant
strength than blueberries. Salba is
all-natural, has no trans-fat, and is
neutral in taste. Plus it absorbs from
8 to 12 times its weight! Fortified with
Organic Maca Root, Salba is Certified Gluten Free, Non-GMO, Vegan
by the AVA and OU Kosher.
407-671-5525
www.salba.com
Nutraceuticals
Daiwa Health
Development, Inc
1411 W. 190th St. Ste. 375
Gardena, CA 90248
USA
Daiwa Health Development focuses
on helping people to live healthy
lives through the application of
bioscience while respecting the
laws of nature. A core neutraceutical from Daiwa is BRM4, a unique
immune modulator, derived from
rice bran. BRM4 is an evidence
based broad spectrum immune
complex with numerous independent research studies.
866-475-4810
www.dhdmed.com
MaxGXL / The Glutathione Accelerator
1326 Armacost Ave. #5B
Los Angeles, CA 90025
USA
909-595-1495
www.maxgxl.com/christian
Metagenics, Inc.
100 Avenida La Pata
USA
800-692-9400
www.metagenics.com
Methode Physiodermie / Europelab Inc.
4930 Bois Franc
St-Laurent, Quebec H4S 1A7
Canada
Natural Clinician, LLC
47 Center Ave
Little Falls, NJ 07424
USA
New Health Corp.
1413 S. Patrick Drive, Ste 3
Indian Harbour Bch, FL 32937
USA
1.800.263.8888
www.derme.ca
973-256-4660
www.naturalclinician.com
877-263-3555
www.newhealthcorp.com
Ortho Molecular Prducts
3017 Business Park Drive
Stevens Point, WI 54481
USA
815-206-6530
www.OrthoMolecularProducts.com
DaVinci Laboratories of Vermont
20 New England Dr.
Essex Junction, VT 05453
USA
Designs For Health
2 North Rd
East Windsor, CT 06088
USA
Douglas Laboratories
700 Trumbull Drive
Pittsburgh, PA 15205
USA
Great HealthWorks, Inc.
1890 N. University Drive # 205
Coral Springs, FL 33071
USA
Isagenix
2426 Orangewood Drive
Durham, NC 27705
USA
Life Extension
1100 West Commercial Blvd
Fort Lauderdale, FL 33309
USA
802-878-5508
www.davincilabs.com
Preferred Medical Supplements
9140 Corsea del Fontana Way 239-597-2010
Naples, FL 34109
www.preferredmedicalUSA
supplements.com
800-847-8302
www.designsforhealth.com
Rejuvenation Science
811 N. Catalina Ave., #3208
Redondo Beach, CA 90277
USA
412-278-6748
www.douglaslabs.com
954-707-5080
www.greathealthworks.com
T.A. Sciences, Inc.
24 E. 64th St., 5th Floor
New York, NY 10065
USA
UAS Laboratories, Inc.
9953 Valley View Rd.
Eden Prairie, MN 55344
USA
919-672-4862
www.gocleanse.com/bodywise
1-800-544-4440
www.lef.org
888-737-3588
www.rejuvenation-science.com
212-588-8805
www.tasciences.com
“DDS Probiotics” Available Since 1979
- Containing L.acidophilus DDS-1
Super Strain
- Acid and bile resistant
- Non-dairy, gluten-free
- High potency, freeze-dried,
nitrogen packed
- Backed by 40+ years research,
U.S. patents and Trademarks
- UAS Labs Provides:
- Probioplus and other probiotic
products under UAS Labs label
- Private Labeling, Custom M
anufacturing available
952-935-1707
www.uaslabs.com
34 ❘
SPRING 2008
Visit Us at Booth 403
tOver 400 unique formulas, powders
and liquids
tExclusively use vegetarian
capsules
t
t
Practices (GMP) company
tComplementary Prescriptions is sold
exclusively through healthcare
practitioners
New GI Cell Support
Helps maintain the integrity
of the intestinal membrane
“The Brand Doctors... Trust”
BUYERS Guide
Ultimate Medical Research
866-319-0566
www.ultimatemedresearch.com
www.nickdelgado.com
USANA Health
Sciences Independent Associate
USANA Nutritional Supplements
are offered directly to physicians
with no need to stock products.
USANA is rated the Top Tier (5 STAR GOLD STANDARD) compared to
the top 1,500 Nutritional Companies in North America. Follows FDA
pharmaceutical good manufacturing practices (GMPs). Meets USP
standards for potency, uniformity,
disintegration, and dissolution. 121 St. Croix Avenue
Cocoa Beach, FL 32931
USA
321-783-7774
www.physiciansnetwork.usana.com
Nutraceuticals / Pharmaceutical /
2007 S. Coast Hwy.
Laguna Beach, CA 92651
USA
Vitamin Research Products
4610 Arrowhead Drive
Carson City, NV 89706
USA
KRS Global
Biotechnology Inc.
791 Park of Commerce
Blvd. Suite 600
USA
877-506-0777
www.gbtbio.com
Medaus Pharmacy
2637 Valleydale Road
Birmingham, AL 35244
USA
Vitarich Laboratories, Inc.
Xango
26323 North 2nd Street
Phoenix, AZ 85027
USA
Xymogen
725 South Kirkman Road
Orlando, FL 32811
USA
239 430-2266
www.vitarichlabs.com
623-879-7231
impact2health.net
2404 West 12th Street, Suite 4
Tempe, AZ 85281
USA
University
Compounding
Pharmacy
1875 3rd Ave.
San Diego, CA 92101
USA
800-647-6100
www.xymogen.com
Auxilium Pharmaceuticals, Inc.
484-321-5900
www.auxilium.com
3 Terri Lane #12
Burlington, NJ 08016
USA
609-386-3030
www.fujihealthscience.com
Hallandale Pharmacy (Pharmcore)
645 W. Hallandale Beach Blvd.
Hallandale, FL 33009
USA
954-455-3822
UCP is a compounding pharmacy
that is board accredited by PCAB.
This certification assures that you
are getting the highest quality
compounds. UCP compounds
a wide variety of compounded
medications used in the age
management market. We deliver
anywhere in the USA. See our
website at www.ucprx.com.
ACASP
Fuji Health Science
877-797-7997
www.nature-throid.com
619-683-2005
www.ucprx.com
Please see ad on pages 30, 73 (SH),
and page 2 (BG)
Pharmaceutical
40 Valley Stream Parkway
Malvern, PA 19355
USA
800-526-9183
www.medaus.com
800-877-2447
www.vrp.com
RLC Labs, INC
4365 Arnold Ave
Naples, FL 34104
USA
KRS Global Biotechnology Inc. introduces Xentropin with GHRP-2. After
years of research and development KRS has found an easy and
effective way to administer GHRP-2
in a digestible strip technology. This
breakthrough is now alllowing for
physicians to quickly and effectively
expand the scope of their practice
to a larger market.
1510 W. Montana St.
Chicago , IL 60614
USA
773-528-1000
ACIGI Relaxation/Fujiiryoki
4399 Ingot Street
Fremont, CA 94538
USA
510-651-9088
www.fujichair.com
36 ❘
SPRING 2008
Weight Management
capability.
7773 Waikapu Loop
Honolulu, HI 96825
USA
808-395-0656
www.ionmagnum.com
808-395-0656
Biospace
Ondamed Inc.
USA
845-496-6673
www.ondamed.net
8820 Wilshire Blvd. Ste.310
Beverly Hills, CA 90211
USA
Ideal Protein
303-503-3420
USA
178 Jean Proulx Suite 202
Gatineau, QC J8Z-1V3
CANADA
232 Avenida Fabricante,
Ste. 110
USA
Degenerative disease and accelerated aging have been attributed
to insufficient cellular stimulation.
As living cells struggle with poor
nutrition, low oxygen levels, environmental toxins, and stagnation of
lymphatic fluids, disease conditions
develop and accelerate again and
shorten lifespan. The solution has
arrived with The Evolution™-whole
body vibration at its finest!
949-485-5427
www.vibrahs.com
7773 Waikapu Loop
Honolulu, HI 96825
USA
808-395-0656
www.ionmagnum.com
Isagenix
2426 Orangewood Drive
Durham, NC 27705
USA
Stem Cell Therapies
®
AssureImmune
3998 FAU Blvd., Suite 215
USA
310-358-0360
www.biospaceamerica.com
866-314-4447
www.labidealprotein.com
Ion Magnum, LLC
Vibration Health
Solutions, Inc.
BUYERS Guide
7773 Waikapu Loop
Honolulu, HI 96825
USA
Stem Cell Therapies / Weight Management
Ion Magnum, LLC
561-750-6030
www.assureimmune.com
Isagenix, world leader in nutritional
cleansing and coaching, offers
sophisticated systems for anti-aging
and weightloss, promoting the
release of environmental impurities
from vital tissues. Patients experience visible dramatic results through
toxic fat loss, return of youthful
appearance, enhanced athletic
and sexual performance, improved
brain chemistry, better sleep, mental
clarity, and increased energy. In
a recent study clients released an
average of 7 pounds in 9 days.
919-672-4862
www.gocleanse.com/bodywise
German Society For Thymus Therapie
Harvestehuder Weg 65
Hamburg, 20149
GERMANY
Ondamed Inc.
USA
+491805849687
www.thymus-therapie.org
Ondamed Inc.
USA
845-496-6673
www.ondamed.net
Take Shape for Life
135 S Sierra Ave #2
Solana Beach, CA 92075
USA
845-496-6673
www.ondamed.net
888-539-9975
www.weightlossdoctor.net
❘ 37
Targeting Cancer’s Sweet Spot
By Maureen Pelletier, MD, CCN, FACOG
Introduction
Dr. Otto Warburg was awarded the
Nobel Prize more than 70 years ago for
his discovery that cancer cells use glucose at a rate 10 to 50 times higher than
healthy cells through direct glycolysis
via non-oxidative pathways.1 Called
“the Warburg Effect,” this characteristic hypermetabolic activity fuels the
explosive growth of cancer, steals glucose from healthy tissue and produces
metabolic byproducts that contribute to
systemic illness. Warburg theorized that
if the uptake of glucose into cancer cells
could be inhibited, their energy supply
could be choked off, slowing or stopping cancer growth and forcing cancer
cells to die.
A few years later, Hungarian biochemist Dr. Albert Szent-Gyorgyi, also
a Nobel Laureate, began seeking the explanation for low rates of cancer among
38 ❘
populations that consume substantial
amounts of whole-grain products, compared to populations that don’t. By the
early 1980s, Szent-Gyorgyi had isolated
natural compounds within wheat germ
that he believed would have anti-cancer
properties if consumed in supplemental
amounts.2
Recent research has linked the findings of these two Nobel Laureates: A
unique fermented wheat-germ extract
(FWGE) blocks glucose uptake within
cancer cells, choking off their energy
supply, reducing their ability to grow
and proliferate, and eventually causing
cancer cell death by apoptosis, without
any detrimental effect to healthy cells.
Seeking Stable Targets
The limitations of conventional cytotoxic anti-cancer treatments such as
radiation and chemotherapy are clear.
They are lethal to both cancerous and
healthy cells, so they produce highly undesirable side effects up to and including raising the risk of future cancers.
These shortcomings led to the development of targeted therapies (i.e., smart
drugs) that inhibit molecular targets
present or overabundant only in cancer
cells. However, the initial exuberance over the early successes of these
targeted therapies has been balanced in
recent years by the discovery that the
mutated genes which produce such molecular targets continue to mutate over
time. This means the molecular targets
assume new shapes over time and are
no longer affected by drugs designed to
bind to an earlier, original version of the
target.3-5
Targets offered by the Warburg Effect
are very different. They are not the
SPRING 2008
Want to Add $10,000-$50,000 of Income
…or More To Your Practice Each Year?
Life Extension Foundation Buyers Club, providers of premiumquality and high-potency vitamins, nutraceuticals, and
hormones, can help you add a substantial, recurring revenue
stream to your practice!
If you regularly recommend supplements and/or hormones,
such as DHEA, pregnenolone, progesterone, or melatonin to
your patients, please check out the Life Extension Physician
Wholesale Program:
s Wholesale Program — buy top-quality supplements at
wholesale discounted prices and resell them direct
to your patients! This program offers
huge profit margins!
Average Yearly Product Sales
Your profit
on 50 patients’
purchases
Your profit
on 100 patients’
purchases
Your profit
on 500 patients’
purchases
PERPATIENTFORYEAR
PERPATIENTEACHYEARFORYEARS
OVERYEARS
OVERYEARS
OVERYEARS
Your income potential is unlimited!
0LEASENOTETHISPROGRAMISAVAILABLEINTHE53ONLY
About the Life Extension Foundation Buyers Club
To find out more, or to
request your free Wholesale
Information Packet, call us at
1-866-638-8082
The Life Extension Foundation Buyers Club is a world leader in the dietary
supplement market with a specific anti-aging focus. We market and sell only
the highest quality, science-based supplements, offering over 400 products,
including many unique formulations. Life Extension was the first to introduce
CoQ10, melatonin, SAMe, lycopene, DHEA, and a host of other breakthrough
nutraceuticals. Proceeds from supplement sales also support anti-aging and
disease-prevention research through the Life Extension Foundation, the
world’s largest, non-profit membership, anti-aging organization.
SPECIAL A4M OFFER
Get free copies of Life Extension magazine for your waiting room, plus a
FREE Life Extension membership for yourself!
Life Extension magazine is source one for the latest scientific and medical information from around the world.
This over-100-page monthly periodical is packed with articles and features on how to prevent disease and fight
premature aging. All articles are fully referenced. Return this form today, and get a free membership for yourself.
O YES! I want to receive a free membership to the Life Extension Foundation, and free copies of Life
Extension magazine for my waiting room. Please send me ____ copies per month. (No more than 3
copies please). )TEM#ODE MEMBCOMP
.AME O YES! Please also send
me a free Wholesale
Information Packet.
#OMPANY
!DDRESS
3TATE
Phone
%MAIL
Please mail completed form to:
,IFE%XTENSIONs7#OMMERCIAL"LVDs&ORT,AUDERDALE&,
/RCALLTOLLFREEsTOLLFREEFAX
423.44_0321.indd 1
:IP
3OURCECODEAVX02A
418.75 CONF 0108
#ITY
3/21/08 2:52:21 PM
Targeting Cancer’s Sweet Spot result of mutated genes. Instead, they are
simply enzymes upon which cancer cells
are far more dependent than are normal
cells. These enzyme targets are stable
over time; essential to tumor cell growth,
survival and proliferation; and are present in virtually all cancers. The opportunity to focus effectively on such targets
has existed in theory for some time, but
has become a reality only in recent years,
as the tools of modern science have
caught up with the wisdom and intuition
of visionaries from three-quarters of a
century ago.
New Tools Illuminate Warburg
Effect Metabolic Targets
Dr. Warburg noted in his Nobel acceptance speech that fully understanding
cell metabolism was extremely difficult
because of the fast and short-lived nature
and overwhelming number of chemical reactions that make up metabolic
pathways.6 He knew what happened –
that cancer cells used large amounts of
glucose to thrive – but he didn’t know the
biochemical details of exactly how they
did so.
In the mid- and late-1990s, researchers developed sophisticated new tools
for studying metabolic reactions in cells
in precise detail.7 One such technique,
called stable isotope-based dynamic metabolic profiling (SiDMAP), uses glucose
tagged with special, heavy isotopes of
carbon (C-13) to trace the use of glucose
in the synthesis of RNA, DNA and fatty
acids. The technique identifies which
key metabolic chemicals can be used as
targets – targets that if blocked can thwart
cancer cells’ ability to obtain energy or to
make the DNA necessary to replicate.
FWGE Inhibits Warburg-Effect
Metabolism
The SiDMAP technique of metabolic
profiling was applied to understanding
how Szent-Gyorgyi’s fermented wheatgerm extract (FWGE) affected metabolism in MIA pancreatic cancer cells.
SiDMAP showed that pancreatic cancer
cells utilized vast amounts of glucose for
40 ❘
the carbon atoms they contain. The Warburg Effect in these cells bypasses the
slower oxygen-dependent pathways of
normal cells. Pancreatic cancer cells utilize the non-oxidative transketolase (TK)
enzyme pathway, incorporating carbon
atoms from glucose to make ribose, the
sugar that forms the backbone of RNA
and DNA required for cancer cell proliferation and tumor metastasis.8
The FWGE produced a radical,
dose-dependent inhibition of transketolase (TK), slowing glucose uptake into
pancreatic cancer cells and inhibiting
the cells’ synthesis of RNA. At the same
time, FWGE increased direct glucose
oxidation and ribose recycling in the
pentose cycle – hallmarks of normal cell
metabolism. The cancer cells were forced
to revert to the metabolic pathways
used by normal cells, using glucose more
for production of fatty acids and cellstructure components and less for ribose.
These metabolic shifts promoted cell
differentiation to normal cell phenotypes
in some cells, and caused death by apoptosis in other cancer cells.9
FWGE has been shown to have similar
results with many other types of cancer.
In a study with Jurkat leukemia, cells
were treated with increasing amounts
of FWGE for 48 and 72 hours.10 TK
activity was inhibited by more than 50
percent in two days and by more than 90
percent in three days. Glucose carbons
going into new nucleic acids so new
cancer cells could be made were reduced
by 40.2 percent, reducing cell proliferation. The leukemia cells’ ability to obtain
energy was inhibited by over 95 percent
in 48 hours by FWGE inhibition of the
activity of hexokinase, an enzyme key to
energy production via glycolysis. Simultaneous inhibition of enzymes key to
both oxidative and non-oxidative glucose
utilization led to apoptosis.
FWGE also inhibited the enzyme
glucose-6-phosphate dehydrogenase
(G6PDH), a metabolic enzyme essential
for using glucose carbons to make ribose
through another pathway. G6PDH levels
fell by more than 90 percent in three
days at a dose of 0.5 mg/ml of FWGE,
and by more than 95 percent in a shorter
time with a higher dose. This showed an
ability of the FWGE to virtually eliminate cancer cell proliferation through
inhibition of both major and minor pathways of cancer cell synthesis of ribose.11
Further evidence that the anti-cancer
effect of FWGE is not dependent on the
cancer type was illustrated in experiments with estrogen-sensitive (ER+) and
estrogen-negative (ER-) breast cancers.
Tumor lines from mice and from humans
were implanted in female mice. FWGE
inhibited ER+ tumors by 50 percent,
better than the 42 percent inhibition
rate for the tamoxifen, 26 percent for
exemestane and 25 percent for anatrozole. On the ER- cancers, the anti-estrogenic drugs tamoxifen, exemestane and
anatrozole have been shown to be ineffective, but FWGE was just as effective,
inhibiting tumor gowth by 52 percent.12
Because FWGE inhibited growth of both
estrogen-sensitive (ER+) and estrogenindependent (ER-) tumors equally, the
data suggest it was the restriction of the
Warburg Effect’s glucose uptake for
energy and cell replication that was responsible, rather than interference with
estrogen activity.
Clinical Anti-Cancer Effects of
FWGE Inhibition of Warburg-Effect
Metabolism
Proof of the principle that FWGE can
inhibit cancers by targeting the Warburg
Effect has been shown in many in vivo
and in vitro experiments and has shown
promise in clinical trials.
In a multicenter clinical trial involving 170 patients with colorectal
cancer, FWGE reduced the risk of
death by almost 70 percent.13 The 66
patients taking supplemental quantities of FWGE had improved overall
survival compared to controls (12.1
percent deaths vs. 31.7 percent); far
fewer recurrences (3.0 percent vs. 17.3
percent) and far fewer metastases (7.6
percent vs. 23.1 percent). FWGE’s
inhibition of glucose uptake and use of
glucose carbons to synthesize ribose for
SPRING 2008
DNA for proliferation were significant
factors in the slower disease progression
and increased survival.
As a result of these and other findings,
FWGE is now part of the standard of care
for colorectal cancer in Hungary, where
FWGE is approved as a medical nutriment in support of patients undergoing
treatment.
Clinical studies of FWGE in squamous
cell cancers of the head and neck
(SCHNN) led a European surgeons association specializing in head and neck
cancers to approve a recommendation
that FWGE be a routine part of the
standard of care for treatment of all such
cancers.14
In the first study, 50 head and neck
cancer patients were treated with
surgery, chemotherapy and/or radiotherapy, with or without the addition of
FWGE. Three years later, the majority of
those receiving FWGE, including five of
six with advanced salivary gland cancer,
had no new recurrences or metastasis.
Benefits of conventional treatments were
enhanced by FWGE, and side effects
were reduced. Patients on FWGE gained
appetite, weight and strength.
In the second study, involving 45 adults
with stage II or stage III cancers of the
mouth, addition of FWGE to surgery,
chemotherapy and radiation reduced the
risk of the cancer progressing to a more
advanced stage by 85.3 percent, mainly
by reducing risk of metastasis (spread). At
five years, 74 percent of FWGE patients
were alive, compared to 45.5 percent of
patients getting only conventional treatment.
In the third study, Italian researchers found that 60 days of FWGE after
surgery and other conventional treatment for advanced head and neck cancer
patients (stages III and IV) improved the
patients’ quality of life (Spitzer QOL
index), lowered oxidative stress and
prevented weight loss in the 22 who got
FWGE, compared to the 33 who didn’t.
This led researchers to report FWGE as
having a pivotal benefit in the treatment
of patients with advanced head and neck
cancers.
FWGE has been shown to slow disease
progression in stage III melanoma pa-
SPRING 2008 tients15 and to improve quality of life and
relieve fatigue in advanced lung cancer.
Conclusion
of cytogenetic aberrations in Philadelphia chromosome positive and negative hematopoiesis during
dasatinib therapy of chronic myeloid leukemia
patients after imatinib failure. Haematologica, 2007
Jun;92(6):834-7.
The data from clinical studies of FWGE
show improved overall survival, improved
disease-free survival, and improved quality of life with no undesirable effects on
healthy tissue. These benefits make it
clear that targeting the mechanisms of
Warburg-Effect metabolism, which is
restricted to cancer cells, provides unique
opportunities to benefit patients without
the undesirable side effects characteristic
of cytotoxic cancer therapies, and without the narrow applicability and target
slippage of “smart” synthetic drugs. The
incredibly innovative and insightful cancer research begun by another century’s
brightest scientists has come full circle.
We now know not just that Warburg
and Szent-Gyorgyi were right, but also
why. We can see how cancer patients
have benefited from the work of these
geniuses, and how and why they are likely
to continue to do so.
Currently, fermented wheat-germ extract is available as the medical nutriment
Avemar® from Biropharma of Budapest,
Hungary, and as the nutritional supplement AvéTM, from American Biosciences
of Blauvelt, N.Y. (1-888-884-7770).
Additional research on FWGE can be
viewed at www.pubmed.gov using the
search term “fermented wheat germ” and
at www.avemarresearch.
4. Kwak EL, Sordella R, Bell DW, et al. Irreversible inhibitors of the EGF receptor may circumvent acquired
resistance to gefitinib. Proc Natl Acad Sci U S A, 2005
May 24;102(21):7665-70.
REFERENCES
15. Demidov LV, et al. Anti-metastatic effect of Avemar
in high-risk melanoma patients. 18th UICC International Cancer Congress, Oslo, Norway, June 30-July 5,
2002. Int J Cancer, 2002;100(S13);408.
1. Xu RH, Pelicano H, Zhou Y, et al. Inhibition of
glycolysis in cancer cells: a novel strategy to overcome
drug resistance associated with mitochondrial
5. Haber DA, Bell DW, Sordella R, et al. Molecular targeted therapy of lung cancer: EGFR mutations and
response to EGFR inhibitors. Cold Spring Harb Symp
Quant Biol, 2005;70:419-26.
6. http://nobelprize.org/nobel_prizes/medicine/laureates/1931/press.html.
7. Lee WN, Boros LG, Puigjaner J, et al. Mass isotopomer
study of the nonoxidative pathways of the pentose
cycle with [1,2-13C2] glucose. Am J Physiol, 1998
May;274(5 Pt 1):E843-51.
8. Boros LG, Lapis K, Szende B, et al. Wheat-germ
extract decreases glucose uptake and RNA ribose
formation but increases fatty acid synthesis in MIA
pancreatic adenocarcinoma cells. Pancreas, 2001
Aug;23(2):141-7.
9. Ibid.
10. Comin-Anduix B, Boros LG, Marin S, et al. Fermented wheat-germ extract inhibits glycolysis/
pentose cycle enzymes and induces apoptosis through
poly(ADP-ribose) polymerase activation in Jurkat
T-cell leukemia tumor cells. J Biol Chem, 2002 Nov
29;277(48):46408-14.
11. Ibid.
12. Telekes A, Tejeda M, Szcs I, et al. Avemar inhibits
growth of mouse and human xenograft mammary
carcinomas comparably to endocrine treatments.
American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, 2007.
13. Jakab F, Shoenfeld Y, Balogh A, et al. A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer, 2003 Aug 4;89(3):465-9.
14. Barabas J, Nemeth Z. [Recommendation of the Hungarian Society for Face, Mandible and Oral Surgery in
the indication of supportive therapy with Avemar.]
Orv Hetil, 2006 Sep 3;147(35):1709-11.
respiratory defect and hypoxia. Cancer Res, 2005 Jan
15;65(2):61.
2. Szent-Gyorgyi A. Int J Quantum Chem Quantum Biol
Symp, 1982;9:27-30.
3. Fabarius A, Haferlach C, Muller MC, et al. Dynamics
◗ Maureen Pelletier, MD, CCN, FACOG
Dr. Pelletier is a lecturer, author and the Director of Functional Medicine
at the LaValle Metabolic Institute in Cincinnati, OH. She specializes in hormone replacement, men’s and women’s health, and is a Defeat Autism
Now (DAN!) physician.
❘ 41

Spring 2008 - Buyers Guide - American Academy of Anti

Transcription

Similar documents

Are Your Hormones Making You Sick?

Fibrovera Singlet

Contraception for the Next Generation

Menopause Update 2014

Medical - Light Sources

freedom plaza washington, dc 9am sunday, march 22, 2015

Benefits of Hormone Replacement Therapy

Cover, Intro and Abstracts - American Academy of Anti