The Immune System Made Simple: Making it Work for You Dr

The Immune System Made Simple:
Making it Work for You
Dr. Sandro Marra Ph.D., ND.A., C.C.N., N.H.C.
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Agenda
• Introduction
• My history
• Questions and expectations
• Body of talk
• Conclusions
• Questions
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Functional Medicine/ Clinical Nutrition
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Science based
Biochemical individuality
Individual not the disease
Web-like interconnections of physiological
factors
Health is balance
Physical, Mental, Emotional, Social,
Spiritual
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Functional Medicine/ Clinical Nutrition
• Health and Illness have a functional
relation
• Prevention is always better
• Body is wise and always tries to win
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Syndromes of Immune Dysregulation
immune state
acute infection
Sub-acute infection
Chronic recurrent
infection
Allergy
Cellular immune
dysfunction
Cancer
dysregulation
Reines BP. Hypothesis. Bystanders or bad seeds? Many auto-immune target cells may signal danger to
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immune system. Autoimmunity. 2001;33(2):121-343
Survival vs. Age
Fries JF. Aging, natural death, and the compression of morbidity. Bulletin of the World Health Organization 2002;
80(3):245-250
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Aging theories
• Telomere the aging timepiece of the cell
• Free radical theory
• Endocrine Theory
• Loss of control of Immune system??
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Slow Down Aging
• Eat healthy
• Regular exercise
• Enough sleep
• Limit exposure to environmental toxins
• Reduce stress
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Why we get sick?
• Infections
• Toxins
• Allergens
• Stress
• Poor diet
• Genes
• Trauma
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Good Questions
• Is this individual suffering of an
unsatisfied need?
– Is he/she lacking something?
• Does this individual suffer from an adverse
reaction or is he/she toxic?
– Is he/she having something in excess?
Sydney Baker, MD
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Graceful Aging / I.S. Intact
• Answer to why Immune System
• 3 out of 7 are directly Immune System related.
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Infections
Toxins
Allergens
Stress
Poor diet
Genes
Trauma
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Immune System
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Immune System
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Immune System
• Innate and Adaptive
• Cellular and Humoral
• Pacman vs Computer
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Th1/Th2 Regulation
• Key to a graceful aging I.S.
• CD4 cells
• Balance between tolerance to self antigen
and activation towards a foreign pathogen
• Allergies and A.I.
• Probiotics Research
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I.S. deficiency
• Pathology
• Frequent colds and infections
• Underlining weakness
• ImmunoBoosting Kit or any other
combination of nutrients/I.S.activators
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I.S. Imbalance/Dysfunction
• Pacman vs. the computer
• Remember the progression
• Concept of inflammation
• Hyperactivation of I.S.
• Allergies, Asthma, A.I.
• Chronic lingering infections
• Ultimately …..
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Syndromes of Immune Dysregulation
immune state
acute infection
Sub-acute infection
Chronic recurrent
infection
Allergy
Cellular immune
dysfunction
Cancer
dysregulation
Reines BP. Hypothesis. Bystanders or bad seeds? Many auto-immune target cells may signal danger to
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immune system. Autoimmunity. 2001;33(2):121-343
Can you do something about it?
• Diet and nutrition
• Exercise and lifestyle changes
• Survey the digestive system
• Supplements
• Probiotics
• Mild detox
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Can we do something about it?
• Interpretation of CBC/Biochemistry
• More sophisticated immunologic tests
• Questionnaires/ Chronological history
• Stool testing and other functional tests
• Trajectory
• Individualized nutritional program
• Follow ups and twicking
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Stem Cells
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CBC/Biochemistry
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GI system
Hepato-Biliary function
Mineral balance
Vitamin Balance
Blood sugar regulation: pancreas and adrenals
Liver function
Kidney function
Thyroid
C.V. system
Immune System
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CBC/Biochemistry
• Infection chronic or acute
• Bacterial or viral or parasitic or fungal
• A.I. processes tissue destruction
• Arthralgias, inflammation
• Gout
• Neuritis
• Allergies and food allergies
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Examples
Bacterial Chronic Infection
Neutrophils
WBC
Lymphocytes
Viral Chronic infection
WBC
Lymphocytes
Monocytes
ESR
LDH
Neutrophils
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CBC/Biochemistry
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CBC/Biochemistry
• Interpretation and experience and many
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workshops, seminar etc on the subject
Body compensates
Detective hat
Know your physiology and biochemistry
Common sense
On going learning
Time consuming process but many times the
only play in town!
Trajectory is important
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Can you do something about it?
• Diet and nutrition
• Exercise and lifestyle changes
• Survey the digestive system
• Supplements
• Probiotics
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I. S. organs
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Digestive System
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Why is it important with respect to I.S.?
Assess functionality by CBC/SMAC
Stool testing but also OAT
Autism Spectrum Disorder (ASD) is a
neuroinflammatory condition/ A.I. neurologic
condition but…
In ASD very often is the blockage to recovery
Gluten and gliadin
In difficult situation ( the large majority)
biofilm/toxin complex
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Gluten/Intestinal Barrier
Fasano A, Shea DonahueT. Mechanism of Disease: the role of intestinal barrier function in the pathogenesis
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of gastrointestinal autoimmune diseases. Nature Clinical Practice Gastroenterology & Hepatology –2005 :2(9): 416
Why Intractable A.I. Conditions?
• Trauma
• Toxins (heavy metals) find an easier route
inside the body
• Microbes, fungi envelop the toxin
• Bad homeostasis established
• Serious Herksheimer’s Reaction
• Individual Detox Capabilities are very
important
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Immune System
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Biofilm
• What is Biofilm
– Biofilm is a self-made protective environment in which
microbial populations hide from the body's immune system and
anti-microbial therapies. Biofilm allows the bugs to evade
surveillance of the immune system and our best attempt to
throw antibiotics at them.
• Role in Chronic Infections
– Biofilm communities can be 1000 times more resistant to
antibiotics than free-floating bacteria.The National Institutes
of Health estimates that nearly 80 percent of chronic microbial
infections are due to biofilm colonies.
• How is Biofilm Produced
– Resistant strains of microorganisms maintain their viability by
producing a polysaccharide matrix that protects them from the
hostile environment in which they are trying to survive. This
extracellular matrix is called biofilm. Our normal flora also
produce a natural biofilm, but resistant organisms produce
their own biofilm which then takes over, preventing the normal
flora from flourishing.
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Biofilm
• Awakening the Immune System
– When the film opens up, we do not know what is under there, and the
immune system may not know what is under there, so you might get
sick And it is not always about killing the bugs. It is more important to
change the gastrointestinal environment so the bugs don't grow.
• The big bumps with this approach are related to awakening the
immune system to these organisms which it has not been
recognizing. The body finally sees the bacteria or the candida that
has been there creating other types of havoc all along.
• Acutely, patients may experience:
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vomiting,
diarrhea,
high temps.
Rashes may appear, especially if the die off is sudden.
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Biofilm
• Heavy Metal Detox
– The other theoretical issue is that the biofilm
may be holding on to toxic metals such as
aluminum and lead. As this toxic biofilm
degrades, heavy metals may be released into
the gastrointestinal tract for excretion.
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Biofilms
• Antibiotic resistant bacteria
• Organization and protection
• Envelop of toxins
• Bad homeostasis/balance
• Need a comprehensive strategy
• CAUTION..CAUTION..CAUTION
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Biofilm
• People with high mercury levels in their
bodies have more:
– Hormonal disturbances,
– Immune disturbances,
– Recurring fungal infections,
– Chronic bacterial infections
• CAUTION..CAUTION..CAUTION
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Can we do something about it?
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•
•
•
•
•
•
Interpretation of CBC/Biochemistry
More sophisticated immunologic tests
Questionnaires/ Chronological history
Nutrigenomic Testing, Stool testing and other
functional tests
Trajectory
Individualized nutritional program
Follow ups and twicking
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PANDAS
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Methyl
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Methylation Cycle
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Methylation Cycle Mutations
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Functional Tests
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GI Effects
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GI Effects
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GI Effects
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OAT
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OAT
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Functional Tests
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