XXXI Winter School Proteinases and Their Inhibitors Tiers am

XXXIst Winter School
on
Proteinases and Their Inhibitors
in
Tiers am Rosengarten
February 26 – March 2, 2014
31st Winter School on Proteinases and Their Inhibitors
in Tiers (Italy)
February 26 – March 2, 2014
Organizing Committee
Klaudia Brix (Bremen)
Christian Sommerhoff (Munich)
Boris Turk (Ljubljana)
Hans Brandstetter (Salzburg)
Editors
Michaela Lassacher & Hans Brandstetter
Dept. Molecular Biology
University of Salzburg
www.uni-salzburg.at/tiers
Supported by
Table of Contents
GENERAL INSTRUCTIONS ............................................................................................................. 6
Accommodation ............................................................................................................................. 6
Social events
............................................................................................................................. 6
Scientific sessions ............................................................................................................................ 6
PROGRAM .......................................................................................................................................... 7
20:00 – 21:35
Wednesday evening: Heavy metal night ............................................................. 7
21:35 – no end
Wednesday Late Night: Fundamentals in Science. ............................................. 7
09:00 – 10:45
Thursday morning I: Lysosomal proteases & their substrates ............................ 8
11:10 – 12:40
Thursday morning II: Alzheimer’s disease ......................................................... 8
14:30 – 16:15
Thursday afternoon I: Cancer biology ................................................................ 9
16:40 – 18:00
Thursday afternoon II: Signaling and cancer biology......................................... 9
09:00 – 10:30
Friday morning I: Active site vistas: substrate recognition and inhibition ....... 10
11:00 – 12:30
Friday morning II: Protein dynamics, recognition & deception ....................... 10
14:30 – 15:45
Friday afternoon I: SERPINs are not for Serine Proteases only ....................... 11
16:15 – 18:00
Friday afternoon II: System wide analysis of proteolytic action ...................... 11
09:00 – 10:50
Saturday morning I: Pathogens ......................................................................... 12
11:10 – 12:55
Saturday morning II: Blood & Aptamer technology......................................... 12
14:30 – 17:00
Saturday afternoon: Hiking, Skiing or Sightseeing in Bozen ........................... 13
5
GENERAL INSTRUCTIONS
Accommodation
Winterschool participants are accommodated in one of the three hotels Rose, Paradies or Vajolet, all
of which are in five minutes walking distance to each other. If you are unsure about your hotel, please
ask at the registration of Hotel Paradies. They have a list of all participants and are happy to help you.
While accommodation and meals including mineral water are covered, any extras are not:



Please pay all drinks (except mineral water) directly after the meal.
Please do not forget to pay your good night-drinks before you leave for sleeping.
Please do not forget to pay all your extras (personal orders, …) at your hotel before
departure.
We wish to actively integrate accompanying persons in all social program events, including meals,
“making new friends in proteolysis”, hiking or sightseeing in Bozen, and the gala dinner. We will
offer reduced registration fees for children. Please contact us.
If you want to rent ski equipment, please ask at the Hotel Paradies.
Social events
 Thursday evening, Paradies:
 Friday evening, City Hall:
 Saturday evening, Castle Haselburg:
Meet and Make Friends in Proteolysis Research
Night session with Hot Can Luck
www.hotcanluck.com
Gala Dinner & Farewell
Scientific sessions
All lectures will take place at the Haus der Dorfgemeinde (City Hall). It is in 5-10 min walking
distance from the hotels.
To enable and foster the unrestrained presentation and discussion of new results and ongoing
research, every Winter School attendee must respect that all contents presented and discussed at the
Winter School are private communications, not allowed for public use. Consequently, recording of
lectures or photographing/copying of slides or presentations is prohibited.
6
PROGRAM
When preparing your talk, please make sure to reserve five minutes for discussion.
WEDNESDAY, FEBRUARY 26
18:00
Dinner
20:00 – no end Wednesday evening: Heavy metal night
20:00 – 20:05 Opening
20:05 – 20:15 Chairs: Walter STÖCKER (University of Mainz) & Øyvind SCHÖNBERGER:
Zinc in proteolysis
20:15 – 20:30 Konstantin KARMILIN (University of Mainz) Inhibition of Astacin
Metalloproteases by Fetuins
20:30 – 20:45 Hagen WESTPHAL (University of Mainz) Ovastacin, a cortical granule protease, is
not oocyte specific
20:45 – 21:00 Jacob LUND (Novo Nordisk Måløv / Aalbourg University) ADAMDEC1 - a
Metzincin Metalloprotease with Dampened Proteolytic Activity
21:00 – 21:15 Sven FRIDRICH (University of Mainz) Who guards the guardians – New role for
Metalloproteases in the context of immunologic regulation
21:15 – 21:30 Esther SCHÖNAUER (University of Salzburg) Clostridial collagenases: Zinc
metalloproteases in need of calcium
21:30 – 21:35 Walter STÖCKER, Øyvind SCHÖNBERGER Digest & wrap up
21:35 – no end Wednesday Late Night: Fundamentals in Science.
Hans FRITZ (University of Munich) Winterschool: Its beginnings, maturation and no
end.
7
THURSDAY, FEBRUARY 27
09:00 – 10:45 Thursday morning I: Lysosomal proteases & their substrates
09:00 – 09:10 Chairs: Christoph PETERS (University of Freiburg): The lysosome as a
headquarter of cellular communication
09:10 – 09:25 Tanja HOCHBERG (University of Freiburg) The role of lysosomal proteases in
proinflammatory signaling of bacteria-infected macrophages
09:25 – 09:40 Elfriede DALL (University of Salzburg) Structural and mechanistic basis of legumain
inhibition by cystatins
09:40 – 09:55 Marcin POREBA (Wroclaw University of Technology) Legumain substrate
specificity determined by Hybrid Combinatorial Substrate Library (HyCoSuL)
approach
09:55 – 10:10 Lovro KRAMER (Jožef Stefan Institute, Ljubljana) Characterization of a cathepsin
S-selective substrate suitable for in vivo imaging
10:10 – 10:25 Regina FISCHER (University of Salzburg) Proteolytic Processing of Allergens
10:25 – 10:40 Maren REHDERS (Jacobs University Bremen) Investigation of potential effects on
thyroglobulin processing enzymes and thyroid hormone transporters in thyroid glands
of mice with induced hypo- or hyperthyroidism
10:40 – 10:45 Christoph PETERS: Wrap up
10:45 – 11:10 COFFEE BREAK
11:10 – 12:40 Thursday morning II: Alzheimer’s disease
11:10 – 11:20 Chairs: Sven DAHMS (FLI Jena) & Uli DEMUTH (Fraunhofer Institute for Cell
Therapy and Immunology; Halle): The complexity of neurodegeneration and
neuroinflammation.
11:20 – 11:35 Stephan SCHILLING (Fraunhofer Institute for Cell Therapy and Immunology; Halle)
N-truncated and Pyroglutamate –Modified (pGlu) Aβ: On the molecular basis of
toxicity and mechanisms of formation in Alzheimer’s Disease
11:35 – 11:50 Rico EICHENTOPF (Fraunhofer Institute for Cell Therapy and Immunology; Halle)
Characterization of Bri(Dan)-hQC double transgenic mice, a model for Familial
Danish Dementia (FDD)
11:50 – 12:05 Linda LIEBE (Fraunhofer Institute for Cell Therapy and Immunology; Halle)
Development of Inhibitors against Bacterial Glutamininyl Cyclase from
Porphyromonas gingivalis
12:05 – 12:20 Nezka KAVCIC (Jožef Stefan Institute, Ljubljana) The effect of different antioxidants
in menadione- and staurosporine-induced oxidative stress
12:20 – 12:35 Nathalie BEAUFORT (Ludwig-Maximilians-University, Munich) Proteolytic
regulation of latent TGF-β binding protein-1 (LTBP-1) by the cerebral small-vessel
disease protease HtrA1
12:35 – 12:40 Sven DAHMS & Uli DEMUTH: Wrap up
12:50
LUNCH (Paradies, Rose)
8
THURSDAY AFTERNOON SESSIONS: CANCER BIOLOGY
14:30 – 16:15 Thursday afternoon I: Cancer biology
14:30 – 14:40 Chairs: Achim KRÜGER (Klinikum rechts der Isar; TU München) & Yoshifumi
ITOH (University of Oxford): Cellular signals by proteases and inhibitors
14:40 – 14:55 Tamara LAH (National Institute of Biology, Ljubljana) Stem cells in cancer: The role
of proteases
14:55 – 15:10 Larissa HILLEBRAND (University of Freiburg) Proteolysis in murine breast cancer
stem cells
15:10 – 15:25 Haissi CUI (Klinikum rechts der Isar; TU München) Tissue inhibitor of
metalloproteinases-1 induces a pro-tumorigenic increase of miR-210 in lung
15:25 – 15:40 Julia KOBUCH (Klinikum rechts der Isar; TU München) Promotion of early tumour
cell homing to the liver by TIMP-1-induced changes in the hepatic microenvironment
15:40 – 15:55 Barbara GRÜNWALD (Klinikum rechts der Isar; TU München) Ectopic elevation of
TIMP-1 in mice is sufficient to induce a pre-metastatic niche in the liver
15:55 – 16:15 Rama KHOKHA (University Health Network, Ontario Cancer Inst.) Exploiting
timpless state to understand metalloproteinase biology
16:15 – 16:40 COFFEE BREAK
16:40 – 18:00 Thursday afternoon II: Signaling and cancer biology
16:40 – 16:50 Chairs: Manfred SCHMITT (Klinikum rechts der Isar; TU München) & Thomas
REINHECKEL (University of Freiburg): Cell signaling and Cancer
16:50 – 17:05 James BURROWS (Queen's University Belfast) The role of USP17 in clathrin
mediated endocytosis
17:05 – 17:20 Christof SEIDL (Klinikum rechts der Isar; TU München) Radionuclide therapy for
peritoneal cancers
17:20 – 17:35 Shihui GUO (University of Salzburg) Biochemical analysis of prostatic kallikreinrelated peptidases from eukaryotic expression systems
17:35 – 17:50 Thomas KRYZA (University of Tours & Queensland University of Technology)
KLK12 stimulates angiogenesis through a PDGF-B dependent paracrine pathway
17:50 – 18:10 James WHISSTOCK (Monash University, Clayton, Victoria) Maspin is not required
for embryonic development or tumour suppression
18:10 – 18:15 Wrap up: Manfred SCHMITT, Thomas REINHECKEL, Achim KRÜGER,
Yoshifumi ITOH
18:30
DINNER (PARADIES, ROSE)
20:00 – 23:00 MEETING AND MAKING FRIENDS IN PROTEOLYSIS RESEARCH
(PARADIES)
9
FRIDAY, FEBRUARY 28
09:00 – 10:30 Friday morning I: Active site vistas: substrate recognition and inhibition
09:00 – 09:10 Chairs: Bob LAZARUS (Genentech) & Dieter JENNE (Helmholtz Zentrum
München): What is a substrate? What is an inhibitor?
09:10 – 09:25 Aleksandra SZALEK (Wroclaw University of Technology) Application of 7-amino-4carbamoylmethylcoumarin (ACC) as a very sensitive fluorophore in design of
internally quenched substrates of endoproteases
09:25 – 09:40 Julian FUCHS (University of Innsbruck) The tight interplay of protease specificity
and active site dynamics
09:40 – 09:55 Natascha PERERA (Helmholtz Zentrum München) Hydrolyzation after unmodified
arginine residues is preferred by NSP4 in birds, mice and men
09:55 – 10:10 Sven DAHMS (FLI Jena) X-ray structures of human Furin in complex with
competitive inhibitors
10:10 – 10:25 Paulina KASPERKIEWICZ (Wroclaw University of Technology) Investigation of
specific activity based probes for Human Neutrophil Serine Proteases
10:25 – 10:30 Bob LAZARUS, Dieter JENNE: Wrap up
10:30 – 11:00 COFFEE BREAK
11:00 – 12:30 Friday morning II: Protein dynamics, recognition & deception
11:00 – 11:10 Chairs: Michael GROLL (TU München) & Christian SOMMERHOFF
(University of Munich): Finding the Needle in the Haystack.
11:10 – 11:25 Birgit WALDNER (University of Innsbruck) Explaining protein-protein interfaces in
protease recognition with local dynamics
11:25 – 11:40 Lisa HINKOFER (Helmholtz Zentrum München) Mechanisms of activity modulating
antibodies in vasculitis
11:40 – 11:55 Therese DAU (Helmholtz Zentrum München) Pathogenic potential of an
autoprocessed form of neutrophil elastase
11:55 – 12:10 Marie-Theres VIELBERG (Technische Universität München) Symmetry mismatch in
bipartite degradation machineries: analysis of PAN-20S proteasome and ClpXP
12:10 – 12:25 Eva HUBER (Technische Universität München) Escaping the inhibitor: drugresistant mutant proteasomes
12:25 – 12:30 Wrap up: Michael GROLL, Christian SOMMERHOFF
12:45
LUNCH (Paradies, Rose)
10
FRIDAY AFTERNOON SESSIONS: PROTEASE SUBSTRATES AND INHIBITORS
14:30 – 15:45 Friday afternoon I: SERPINs are not for Serine Proteases only
14:30 – 14:40 Chairs: Jim HUNTINGTON (University of Cambridge) & Wolfram BODE (MPI
Martinsried): SERPIN-Protease inhibition: When the tail wags the dog – or why
such a complex inhibitor?
14:40 – 15:00 Jan POTEMPA (Jagiellonian University, Krakow) Unusually Broad Specificity of a
Bacterial Serpin (Miropin) Is Due to Recognition of Different Peptide Bonds Within
the Reactive Site Loop
15:00 – 15:20 Diana SCHMERLER (Universitätsklinikum Jena) Quantification of a proteolytic
fragment of alpha-1-antitrypsin as sepsis biomarker and its part in the pathogenesis of
sepsis
15:20 – 15:40 Christopher OVERALL (University of British Columbia, Vancouver) Unexpected
Encounters with Metalloproteinases: System-wide Analysis of Proteolysis in vivo
uncovers the Metallic Serpin Switch
15:40 – 15:45 Jim HUNTINGTON & Wolfram BODE
15:45 – 16:15 COFFEE BREAK
16:15 – 18:00 Friday afternoon II: System wide analysis of proteolytic action
16:15 – 16:25 Chairs: Ulrich AUF DEM KELLER (ETH Zurich) & Oliver SCHILLING
(University of Freiburg): The gap between molecular and cellular biology
16:25 – 16:40 Alejandro GOMEZ-AULI (University of Freiburg) Secretome profiling of the
interstitial fluid of murine breast cancer
16:40 – 16:55 Nikolaus FORTELNY (University of British Columbia) Pervasive interactions of
proteases and their inhibitors form protein networks as part of a global protease web
16:55 – 17:10 Ulrich ECKHARD (University of British Columbia) Annotating protein N-termini for
the Human Proteome Project: Nα-acetylation, N-terminal methionine excision and
proteolytic processing as crucial events in the life of a protein and proteolytic
signatures as precise reflections of the functional state of a biological system
17:10 – 17:25 Elizabeth HAMSON (University of Sydney / University of Freiburg) Fibroblast
Activation Protein (FAP) degradomics highlights the role of FAP in extracellular
matrix
17:25 – 17:40 Fábio SABINO (ETH Zurich) Exploring the wound degradome
17:40 – 17:55 Pascal SCHLAGE (ETH Zurich) Time-resolved analysis of the matrix
metalloproteinase 10 substrate degradome
17:55 – 18:00 Ulrich AUF DEM KELLER & Oliver SCHILLING Wrap up
18:15
DINNER (PARADIES, ROSE)
20:00 – 23:45 NIGHT SESSION (CITY HALL)
11
SATURDAY, MARCH 1
09:00 – 10:50 Saturday morning I: Pathogens
09:00 – 09:10 Chairs: Jan POTEMPA (Jagiellonian University, Krakow) & Boris TURK (Jožef
Stefan Institute, Ljubljana): How to fight foes (and friends)
09:10 – 09:25 Juliane BENZ (Max-Planck Institute, Heidelberg) T6SS cysteine proteases involved in
bacterial warfare.
09:25 – 09:40 Malgorzata BENEDYK (Jagiellonian University, Krakow) Role of Arginine-specific
Gingipains of Porphyromonas gingivalis in Development of Aspiration Pneumonia
09:40 – 09:55 Dominika STANIEC (Jagiellonian University, Krakow) A Novel Cysteine Peptidase
Tpr from Porphyromonas gingivalis W83 – Characterization and Interaction with
Cystatins
09:55 – 10:10 Thomas SCHMIDT (University of Salzburg) Helicobacter pylori HtrA cleaves ECadherin: identification of cleavage sites
10:10 – 10:25 Magdalena WIDZIOLEK (Jagiellonian University, Krakow) Porphyromonas
gingivalis Kgp Mutants as a Tool for Studying Structure/Function Relationship of
Haemagglutinin/Adhesion Domains
10:25 – 10:45 Edgar DEU (MRC National Institute for Medical Research, London) Malarial
Dipeptidyl Aminopeptidases: Biological Functions and Development of Inhibitors
10:45 – 10:50 Jan POTEMPA, Boris TURK: Wrap up
10:50 – 11:10 COFFEE BREAK
11:10 – 12:55 Saturday morning II: Blood & Aptamer technology
11:10 – 11:20 Chairs: Thomas ZÖGG (University of Salzburg) & Viktor MAGDOLEN
(Klinikum rechts der Isar; TU München): How to deal with too little or too much of
protease activity
11:20 – 11:35 Agnese PETRERA (University of Freiburg) Cardioprotective effect of a novel
cathepsin A inhibitor
11:35 – 11:50 Maria Luiza Vilela OLIVA (University of Sao Paulo) The Kallikrein inhibitor from
Bauhinia bauhinioides (BbKI) shows antithrombotic properties in venous and arterial
thrombosis models
11:50 – 12:05 Han FANG (University of Salzburg) Human blood coagulation Factor VIII
expression, purification and characterizastion
12:05 – 12:20 Line HYLTOFT-KRISTENSEN (Novo Nordisk A/S, Måløv & University of
Salzburg) Application of Biophysical and Kinetic Approaches To Evaluate Different
Conformational States of FIXa During Catalysis
12:20 – 12:35 Henning ULRICH (University of Sao Paulo) Development of aptamers as inhibitors
and allosteric modulators of protease activity
12:35 – 12:50 Günther KRIECHHAMMER (University of Sao Paulo) Aptamers: New tools in
serine proteases targeting
12:50 – 12:55 Thomas ZÖGG, Viktor MAGDOLEN: Wrap up
13:15
LUNCH
12
SATURDAY AFTERNOON: ROUND TABLE DISCUSSIONS
14:30 – 17:00 Saturday afternoon: Hiking, Skiing or Sightseeing in Bozen
19:00
GALA DINNER AT CASTLE HASELBURG
SUNDAY, MARCH 2
10:00
Bus departure
13
ABSTRACTS
Abstracts are not included in the online-version of the program.
14
LIST OF PARTICIPANTS
THE WINTER SCHOOL FACEBOOK
15
The Winterschool Facebook
Wolfram BODE
Max Planck Institute of
Biochemistry
Proteinase Research Group
Am Klopferspitz 18
D-82152 Martinsried
Germany
[email protected]
 +49 89 8504807
Dominik ALTERAUGE
Frauenklinik der TU München
Klinische Forschergruppe
Schneckenburgerstraße 6
D-81675 Munich
Germany
[email protected]
 +49 89 4140 7412
Ulrich AUF DEM KELLER
ETH Zurich
Institute of Molecular Health
Sciences
HPL F14.2
Otto-Stern-Weg 7
CH-8093 Zurich
Switzerland
[email protected]
 +41 44 633 3392
Hans BRANDSTETTER
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7270
Barbara BREZNIK
National Institute of Biology
Dept. Genetic Toxicology
and Cancer Biology
Večna pot 111
SI-1000 Ljubljana
Slovenia
[email protected]
 +3865 92 32 870
Nathalie BEAUFORT
Ludwig-MaximiliansUniversity
Institute for Stroke and
Dementia Research
Max-Lebsche-Platz 30
D-81377 Munich
Germany
[email protected]
 +49 89 7095 8364
Mirko BUCHHOLZ
Fraunhofer Institute for Cell
Therapy and Immunology (IZI)
Leipzig
Dept. Drug Design and Target
Validation (MWT) Halle
Biocenter
Weinbergweg 22
D-06120 Halle (Saale)
Germany
[email protected]
 +49 345 13142800
Malgorzata BENEDYK
Jagiellonian University
Faculty of Biochemistry,
Biophysics and Biotechnology
Gronostajowa 7
PL-30-387 Krakow
Poland
[email protected]
 +48 12 6646378
Juliane BENZ
Max-Planck Institute for
Medical Research
Dept. Biomolecular Mechanisms
Jahnstraße 29
D-69120 Heidelberg
Germany
[email protected]
 +49 6221-486-515
James BURROWS
Queen's University Belfast
School of Pharmacy
97 Lisburn Road
Belfast, BT9 7BL
Northern Ireland, UK
[email protected]
 +44 28 9097 2703
I
Edgar DEU
MRC National Institute for
Medical Research
Division of Parasitology
The Ridgeway
London NW7 1AA
United Kingdom
[email protected]
 +44 20 8816 2668
Haissi CUI
Klinikum rechts der Isar der
TU München
Institut für Experimentelle
Onkologie und
Therapieforschung
Ismaninger Straße 22
D-81675 Munich
Germany
[email protected]
 +49 89 4140 4459
Marcin DRAG
Wroclaw University of
Technology
Department of Chemistry
Wyb. Wyspianskiego 27
PL-50-370 Wroclaw
Poland
[email protected]
 +48 71 320 4526
Sven O. DAHMS
Leibniz Institute for Age
Research
Fritz Lipmann Institute
Beutenbergstraße 11
D-07745 Jena
Germany
[email protected]
 +49 3641 656208
Ulrich ECKHARD
University of British Columbia
Centre for Blood Research
2350 Health Sciences Mall
Vancouver, BC V6T 1Z3
Canada
[email protected]
 +1 604 822 3561
Elfriede DALL
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7278
Fabian EGLI
ETH Zurich
Institute of Molecular Health
Sciences
HPL F17.2
Otto-Stern-Weg 7
CH-8093 Zurich
Switzerland
[email protected]
 +41 44 633 3392
Therese DAU
Helmholtz Zentrum München
Comprehensive Pneumology
Center
Max-Lebsche-Platz 31
D-81377 Munich
Germany
[email protected]
 +49 89 31871653
Rico EICHENTOPF
Fraunhofer Institute for Cell
Therapy and Immunology (IZI)
Leipzig
Dept. Drug Design and Target
Validation (MWT) Halle
Biocenter
Weinbergweg 22
D-06120 Halle (Saale)
Germany
[email protected]
 +49 345 13142800
Hans-Ulrich DEMUTH
Fraunhofer Institute for Cell
Therapy and Immunology
(IZI) Leipzig
Dept. Drug Design and
Target Validation (MWT)
Halle, Biocenter
Weinbergweg 22
D-06120 Halle (Saale)
Germany
[email protected]
 +49 345 13142800
II
Han FANG
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7200
Hans FRITZ
Ludwig-MaximiliansUniversity Munich
Dept. Clinical Chemistry
and Clinical Biochemistry
Nußbaumstraße 20
D-80336 Munich
Germany
[email protected]
 +49 8178 1534
Matthias FELTEN
Johannes Gutenberg
University of Mainz
Dept. Cell and Matrix Biology
Johannes-Joachim-Becher
Weg 9-11
D-55128 Mainz
Germany
[email protected]
 +49 6131 24271
Julian FUCHS
University of Innsbruck
Dept. Theoretical Chemistry
Innrain 80/82
A-6020 Innsbruck
Austria
[email protected]
 +43 512 507 57131
Regina FISCHER
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7277
Peter GÖTTIG
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7283
Nikolaus FORTELNY
University of British
Columbia
Dept. Biochemistry and
Molecular Biology
Centre for Blood Research
2350 Health Sciences Mall
Vancouver, BC V6T 1Z3
Canada
[email protected]
 +1 604 822 3561
Alejandro GOMEZ-AULI
Albert-Ludwigs-University
Freiburg
Institute of Molecular
Medicine and Cell Research
Stefan-Meier-Straße 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 203 9603
Sven FRIDRICH
Johannes Gutenberg
University of Mainz
Dept. Cell and Matrix
Biology
Johannes-Joachim-Becher
Weg 9-11
D-55128 Mainz
Germany
sven.fridrich@ uni-mainz.de
 +49 6131 24271
Michael GROLL
Technische Universität
München
Dept. Biochemistry
Lichtenbergstraße 4
D-85748 Garching/Munich
Germany
[email protected]
 +49 89 289 13361
III
Lisa HINKOFER
Helmholtz Zentrum München
Comprehensive Pneumology
Center
Max-Lebsche-Platz 31
D-81377 Munich
Germany
[email protected]
 +49 89 31871627
Barbara GRÜNWALD
Klinikum rechts der Isar der
TU München
Institut für Experimentelle
Onkologie und
Therapieforschung
Ismaningerstraße 22
D-81675 Munich
Germany
[email protected]
 +49 89 4140 4459
Tanja HOCHBERG
Albert-Ludwigs-University of
Freiburg
Institute of Molecular Medicine
and Cell Research
Stefan Meier Straße 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 203 9633
Shihui GUO
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7283
Elizabeth HAMSON
Liver Injury and Cancer
Centenary Institute, Sydney,
Australia &
University of Freiburg
Institute for Molecular
Medicine and Cell Research
Stefan-Meier-Strasse 17
D-79104 Freiburg
Germany
[email protected]
 +61 413166621
Eva HUBER
Technische Universität München
Dept. Biochemistry
Lichtenbergstraße 4
D-85748 Garching/Munich
Germany
[email protected]
 +49 89 289 13354
James A. HUNTINGTON
University of Cambridge
Institute for Medical Research
Dept. Haematology
Cambridge CB2 0XY
United Kingdom
[email protected]
 +44 1223 763 230
Andrea HENZE
University of Potsdam
Institute for Nutritional
Science
Arthur-Scheunert-Allee
114-116
D-14558 Nuthetal
Germany
[email protected]
 +49 33200 885539
Line HYLTOFT KRISTENSEN
University of Salzburg
Dept. Molecular Biology &
Novo Nordisk
Biopharmaceutical Research
Unit
Novo Nordisk Park
DK-2760 Måløv
Denmark
[email protected]
 +45 3079 8035
Larissa HILLEBRAND
Albert-Ludwigs-University of
Freiburg
Institute of Molecular Medicine
and Cell Research
Stefan Meier Straße 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 203 9633
IV
Rama KHOKHA
University Health Network
Ontario Cancer Institute
610 University Avenue
Toronto, ON M5G 2M9
Canada
[email protected]
 +1 416 946 2051
Yoshifumi ITOH
University of Oxford
Kennedy Institute of
Rheumatology
Roosevelt Drive, Headington
Oxford OX3 7FY
United Kingdom
[email protected]
 +44 1865 612647
Julia KOBUCH
Klinikum rechts der Isar der TU
München
Institut für Experimentelle
Onkologie und
Therapieforschung
Ismaningerstraße 22
D-81675 Munich
Germany
[email protected]
 +49 89 4140 4459
Dieter JENNE
Helmholtz Zentrum München
Comprehensive Pneumology
Center
Max-Lebsche-Platz 31
D-81377 Munich
Germany
[email protected]
 +49 89 31874664
Konstantin KARMILIN
Johannes Gutenberg
University of Mainz
Dept. Cell and Matrix
Biology
Johannes-Joachim-Becher
Weg 9-11
D-55128 Mainz
Germany
[email protected]
 +49 6131 24127
Michael BADER
Omnibusunternehmen Habermayr
Schleifmühlweg 14
D-86633 Neuburg/Donau
Germany
[email protected]
 +49 84 31-20 02
Lovro KRAMER
Jožef Stefan Institute
Dept. Biochemistry and
Molecular Biology
Jamova cesta 39
SI-1000 Ljubljana
Slovenia
[email protected]
 +386 1 477 3510
Paulina KASPERKIEWICZ
Wroclaw University of
Technology
Department of Chemistry
Wyb. Wyspianskiego 27
PL-50-370 Wroclaw
Poland
[email protected]
 +48 71 320 24 55
Günther KRIECHHAMMER
University of São Paulo
Institute of Chemistry
Av. Prof. Lineu Prestes 748
BR-05508-900 São Paulo
Brazil
[email protected]
 +55 11 3091 3839
Nežka KAVČIČ
Jožef Stefan Institute
Dept. Biochemistry and
Molecular Biology
Jamova cesta 39
SI-1000 Ljubljana
Slovenia
[email protected]
 +386 1 477 3410
V
Achim KRUEGER
Klinikum rechts der Isar,
Technische Universität
München
Institut für Experimentelle
Onkologie & Therapieforschung
Ismaningerstraße 22
D-81675 Munich
Germany
[email protected]
 +49 89 4140 4463
Linda LIEBE
Fraunhofer Institute for Cell
Therapy and Immunology (IZI)
Leipzig
Dept. Drug Design and Target
Validation (MWT) Halle
Biocenter
Weinbergweg 22
D-06120 Halle (Saale)
Germany
[email protected]
 +49 345 13142800
Thomas KRYZA
Université François Rabelais
Centre d'étude des pathologies
pulmonaires
Faculté de médecine
10 boulevard tonnelé, bat47c
F-37032 Tours
France
[email protected]
 +33625441417
Jacob LUND
Aalborg University
Dept. Chemistry and
Biotechnology &
Novo Nordisk A/S
Dept. Haemophilia Biochemistry
Sohngaardsholmsvej 49
Dk-9000, Aalborg
Denmark
[email protected]
 +45 61672902
Tamara LAH
National Institute of Biology
Dept. Genetic Toxicology and
Cancer Biology
Večna pot 111
SI-1000 Ljubljana
Slovenia
[email protected]
 +386 41 651 629
Viktor MAGDOLEN
Frauenklinik der TU München
Klinische Forschergruppe
Klinikum rechts der Isar
Ismaningerstraße 22
D-81675 Munich
Germany
[email protected]
 +49 89 4140 2493
Michaela LASSACHER
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7200
Ann-Christin MEINECKE
Fraunhofer Institute for Cell
Therapy and Immunology (IZI)
Leipzig
Dept. Drug Design and Target
Validation (MWT) Halle
Biocenter
Weinbergweg 22
D-06120 Halle (Saale)
Germany
[email protected]
 +49 345 13142800
Robert A. LAZARUS
Genentech Inc.
Dept. Early Discovery
Biochemistry
1 DNA Way
South San Francisco, CA
94030
USA
[email protected]
 +1 650 225 1166
VI
Agnese PETRERA
University of Freiburg
Institute for Molecular
Medicine and Cell Biology
Stefan-Meier-Strasse 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 203 9614
Mario OLF
Johannes Gutenberg University
of Mainz
Dept. Cell and Matrix Biology
Johannes-Joachim-Becher Weg
9-11
D-55128 Mainz
Germany
[email protected]
 +49 6131 24271
Marcin POREBA
Wroclaw University of
Technology
Department of Chemistry
Wyb. Wyspianskiego 27
PL-50-370 Wroclaw
Poland
[email protected]
 +48 71 320 24 55
Maria Luiza Vilela OLIVA
Universidade Federal de São
Paulo-Escola
Paulista de Medicina
Departamento de Bioquímica
Rua Três de Maio, Vila
Clementino
São Paulo, São Paulo
Brazil
[email protected]
 +55 11 5576 4445 1084
Barbara POTEMPA
University of Louisville
School of Dentistry
Center for Oral Health and
Systemic Diseases
501 South Preston Street
Louisville, KY 40202
USA
[email protected]
 +1 502 852 1319
Christopher OVERALL
University of British
Columbia
Centre for Blood Research
4401-2350 Health Sciences
Mall
Vancouver, BC V6T 1Z3
Canada
[email protected]
 +1 604 822 2958
Jan POTEMPA
Jagiellonian University,
Krakow &
University of Louisville
School of Dentistry
Center for Oral Health and
Systemic Diseases
501 South Preston Street
Louisville, KY 40202
USA
[email protected]
 +48 12 664 6343
Natascha PERERA
Helmholtz Zentrum
München
Comprehensive
Pneumology Center
Max-Lebsche-Platz 31
D-81377 Munich
Germany
[email protected]
 +49 3187 1627
Jelena RAJKOVIC
Jožef Stefan Institute
Dept. Biochemistry and
Molecular and Structural
Biology
Jamova cesta 39
SI-1000 Ljubljana
Slovenia
[email protected]
 +386 1 477 3510
Christoph PETERS
University of Freiburg
Institute for Molecular
Medicine and Cell
Research
Stefan-Meier-Strasse 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 203 9601
VII
Pascal SCHLAGE
ETH Zurich
Institute of Molecular Health
Sciences
HPL F17.2
Otto-Stern-Weg 7
CH-8093 Zurich
Switzerland
[email protected]
 +41 44 633 3392
Maren REHDERS
Jacobs University Bremen
School of Engineering and
Science
MOLIFE Research Center
Campus Ring 1
D-28759 Bremen
Germany
[email protected]
 +49 421 200 3159
Thomas REINHECKEL
Albert-Ludwigs-University of
Freiburg
Institute of Molecular
Medicine and Cell Research
Stefan Meier Straße 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 203 9606
Diana SCHMERLER
University Hospital Jena
Institute for Clinical Chemistry
and Laboratory Medicine
Erlanger Allee 101
D-07743 Jena
Germany
[email protected]
 +49 3641 9325193
Fabio SABINO
ETH Zurich
Institute of Molecular
Health Sciences
HPL F17.2
Otto-Stern-Weg 7
CH-8093 Zurich
Switzerland
[email protected]
 +41 44 633 3392
Thomas SCHMIDT
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7212
Oliver SCHILLING
University of Freiburg
Institute for Molecular
Medicine and Cell Research
Stefan Meier Strasse 17
D-79104 Freiburg
Germany
[email protected]
 +49 761 2039615
Manfred SCHMITT
Frauenklinik der TU München
Klinikum rechts der Isar
Ismaningerstraße 22
D-81675 München
Germany
[email protected]
 +49 89 4140 2449
Stephan SCHILLING
Fraunhofer Institute for Cell
Therapy and Immunology (IZI)
Leipzig
Dept. Drug Design and Target
Validation (MWT) Halle
Biocenter
Weinbergweg 22
D-06120 Halle (Saale)
Germany
[email protected]
 +49 345 13142800
Esther SCHÖNAUER
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7277
VIII
Dominika STANIEC
Jagiellonian University
Faculty of Biochemistry,
Biophysics and Biotechnology
Gronostajowa 7
PL-30-387 Krakow
Poland
[email protected]
 +48 12 6646386
Øyvind L. SCHÖNBERGER
Munich
[email protected]
 +43 152 0643 4404
Tom SCHULZE
Frauenklinik der TU München
Klinische Forschergruppe
Klinikum rechts der Isar
Ismaningerstraße 22
D-81675 Munich
Germany
[email protected]
 +49 89 4140 7412
Walter STÖCKER
Johannes Gutenberg University
of Mainz
Institute of Zoology, Cell and
Matrix Biology
Johannes-von-Müller-Weg 6
D-55128 Mainz
Germany
[email protected]
 +49 6131 3924273
Chris SCOTT
Queen’s University Belfast
School of Pharmacy
97 Lisburn Road
Belfast, BT9 7BL
Northern Ireland, UK
[email protected]
 +44 28 9097 2350
Aleksandra SZALEK
Wroclaw University of
Technology
Department of Chemistry
Wyb. Wyspianskiego 27
50-370 Wroclaw
Poland
[email protected]
 +48 71 320 2455
Christof SEIDL
Frauenklinik der TU
München
Klinische Forschergruppe
Klinikum rechts der Isar
Ismaningerstraße 22
D-81675 Munich
Germany
[email protected]
 +49 89 4140 4558
Boris TURK
Jožef Stefan Institute
Dept. Biochemistry and
Molecular Biology
Jamova cesta 39
SI-1000 Ljubljana
Slovenia
[email protected]
 +386 1 477 3772
Christian SOMMERHOFF
Ludwig-MaximiliansUniversity
Institute of Laboratory
Medicine
Nussbaumstraße 20
D-80336 Munich
Germany
[email protected]
 +49 89 5160 5153
Henning ULRICH
University of São Paulo
Institute of Chemistry
Dept. Biochemistry
Av. Prof. Lineu Prestes 748
SP 05508-000 São Paulo
Brazil
[email protected]
 +55 11 3091 8512
IX
Marie-Theres VIELBERG
Technische Universität
München
Dept. Biochemistry
Lichtenbergstraße 4
D-85748 Garching/Munich
Germany
[email protected]
 +49 89 289 13354
Magdalena WIDZIOLEK
Jagiellonian University
Faculty of Biochemistry,
Biophysics and Biotechnology
Gronostajowa 7
PL-30-387 Krakow
Poland
[email protected]
 +48 504 208 016
Irene YIALLOUROS
Johannes Gutenberg
University of Mainz
Institute of Zoology
Dept. Cell and Matrix Biology
Johannes-von-Müllerweg 6
D-55128 Mainz
Germany
[email protected]
 +49 6131 39 26657
Birgit WALDNER
University of Innsbruck
Center for Chemistry and
Biomedicine (CCB)
Institute of General, Inorganic
and Theoretical Chemistry
Innrain 80/82
A-6020 Innsbruck
Austria
[email protected]
 +43 512 507 57137
Thomas ZÖGG
University of Salzburg
Dept. Molecular Biology
Billrothstraße 11
A-5020 Salzburg
Austria
[email protected]
 +43 662 8044 7271
Hagen WESTPHAL
Johannes Gutenberg
University of Mainz
Dept. Cell and Matrix
Biology
Johannes-Joachim-Becher
Weg 9-11
D-55128 Mainz
Germany
[email protected]
 +49 6131 39 24125
James C. WHISSTOCK
Monash University
Dept. Biochemistry & Molecular
Biology
Bldg 77, Wellington Road
Clayton, Victoria 3800
Australia
[email protected]
 +61 3 9902 9312
X