A double-blind, placebo

Transcription

Presentazione delle Ricerche in corso
sulle medicine tradizionali del
Centro di Documentazione
Prof. Emilio Minelli
Centro Collaborante OMS per la Medicina Tradizionale
Università degli Studi di Milano
COS’E’?
Medicina Tradizionale /Medicina Complementare
MT/MC secondo l’OMS:
¾ prezioso patrimonio di conoscenze, accumulate dalle
diverse comunità etniche nei secoli
¾ fonte inesauribile di esperienze teoriche e pratiche
¾ contributo alla promozione e alla tutela della salute
dell’umanità, a costi inferiori rispetto a quelli del sistema
medico occidentale
¾ più facilmente accettate da molte comunità etniche per il
riferimento a credenze e opinioni omogenee alle differenti
culture tradizionali
WHO-TRM Strategy 2002-2005
TERAPIE E TECNICHE TERAPEUTICHE USATE
COMUNEMENTE DALLA MC/MT
Medicina
cinese
Ayurveda
Unani
Osteopatia
Omeopatia
Omeoterapie
Antroposofia
C
C
C
T
T
C
Agopuntura/
Agopressione
C
C
Terapie
manuali
T
C
C
I
T
C
C
C
Fitoterapici
Terapie
spirituali
Esercizi
T
T
T
Chiropratica
T
C
Incorpora comunemente questa terapia/tecnica terapeutica
T
Incorpora talvolta questa terapia/tecnica terapeutica
I
Incorpora il tocco terapeutico
Epistemologia e MT/MC
Feyerabend
Kuhn
[…] se le organizzazioni
[…] ci troviamo di
fronte a due mondi che
concettuali interne delle diverse
teorie scientifiche, sono
incommensurabili,
per
l’incommensurabilità
delle culture,
che si pone a partire da
diversi principi logici,
sono condannati
all’incomprensione […]
ma se il linguaggio ha natura
metaforica e,
contemporaneamente, descrive e
istituisce il mondo,
esso ha anche un carattere
autotrasformativo ed è passibile
di approssimazioni ai significati
espressi da altre culture
Le basi per la diffusione della MT/MC
2000 HEALTH FOR ALL
1979 Dichiarazione di Alma-Ata
Cure Primarie disponibili per tutta la
popolazione
Popolazioni mondiali che
usano TM/CAM
Paesi che usano la
medicina tradizionale
all’interno delle cure
primarie
Paesi in via di sviluppo
che hanno usato la
medicina complementare
e alternativa almeno una
volta
Ethiopia
Benin
70%
India
70%
Rwanda
70%
90%
Tanzania
60%
Uganda
60%
80%
Germany
Canada
70%
France
49%
Australia
48%
USA
42%
Sources: Eisenberg DM et al. 1998; Fisher P & Ward A, 1994; Health Canada, 2001;
World Health Organization, 1998; and government reports submitted to WHO.
Countries' progress in the field of
TM/CAM
WHO Global Survey and Database of National
Policy and Regulation of TM/CAM and Herbal
Medicines including information from 142 of
192 countries, 2004
Summary report of the global survey on
national policy on traditional medicine and
regulation of herbal medicines 2005
Number of Member States with Recently
Established Herbal Medicines Law or Regulation
16
65% of
respondents
have
stablished
herbal
medicine law
or regulation
14
12
10
8
6
4
2
0
Before 1986 - 1988 - 1990 - 1992 - 1994 - 1996 - 1998 - 2000 - 2002 1986 1987 1989 1991 1993 1995 1997 1999 2001 2003
14
4
5
2
8
7
13
Number of Countries before 1986: 14
Number of Countries Total:
83
16
9
5
42 (49%)
declared
regulations
were in the
process of
being
developed.
Main Difficulties Regarding Regulatory
Issues on Traditional Medicines
102
Lack of research data
Lack of appropriate control
mechanisms
88
Lack of education and
training
81
64
Lack of expertise
Other
33
Member States' needs for WHO
Support
Member States' needs for WHO support
Information-sharing on regulatory issues
44
83
4
127
Herbal medicine safety monitoring workshops
68
48
7
116
General guidelines on research and evaluation of
herbal medicines
70
47
5
117
50
3
117
Provision of databases
67
Herbal medicine regulation workshops
66
50
Global meetings
Much needed
Needed
Not needed
44
110
9
55
12
105
16 8 0
Other
0
20
40
60
80
100
Number of Member States
120
140
Relazioni intercorrenti tra
sistema allopatico e
TM/CAM
•
Nei paesi in cui il sistema
sanitario è basato sulla
medicina allopatica, o in
quelli in cui la Medicina
Tradizionale non è stata
incorporata nel sistema
sanitario
nazionale,
la
Medicina Tradizionale è
spesso chiamata
•
“complementare”
•
“alternativa”
•
“non-convenzionale”
Tre sistemi di relazione:
•1.
integrato
•2.
inclusivo
•3.
tollerante
WHO Traditional Medicine
Strategy 2002-2005
1
Policy:
integrate TM/CAM with
national health care systems
Safety,
efficacy
and
quality:
2 provide evaluation, guidance and
support for effective regulation
Access:
ensure availability and
3
affordability of TM/CAM, including
essential herbal medicines
4
Rational use:
promote
therapeutically-sound use of TM/CAM
by providers and consumers
Evidence base for traditional medicine
A
A. Clinical trial of randomizing
control (RCT)
8%
B
B. Well conduct clinical study
C
C. Expert committee review or
clinical experience of respected
authors
28%
14%
“Using Clinical Guidelines to Improve Patient Care within the NHS 1996
L’Efficacia e il dibattito sulle Evidenze
DEFINIZIONE DEL LIVELLO DI EVIDENZA
[Tratto da USA Agency for Health Care Policy and Research, 1992]
Livelli di evidenza
•
I a) Evidenza ottenuta da studi di meta-analisi effettuata su trials controllati
randomizzati
•
I b) Evidenza ottenuta da almeno un trial controllato randomizzato
•
II a) Evidenza ottenuta da almeno uno studio ben definito controllato senza
randomizzazione
•
II b) Evidenza ottenuta da almeno un altro tipo di studio opportunamente
definito, quasi-sperimentale
•
III) Evidenza ottenuta da studi ben definiti descrittivi non sperimentali, come
per esempio studi comparativi, studi di correlazione e studi basati su singoli
casi
•
IV) Evidenza ottenuta da rapporti o opinioni di comitati di esperti e/o
dall’esperienza clinica di autorità competenti
[“General
guidelines for methodologies on research and evaluation
of traditional medicine”, WHO, Hong Kong SAR 2000]
Entusiasmo acritico versus scetticismo disinformato
9 Molti sostenitori della TM/CAM spesso ricercano
riconoscimenti continui—e talora indebiti—per l’efficacia della
TM/CAM nei diversi campi di azione.
9 Molti professionisti della medicina allopatica, spesso
appartenenti a paesi con una forte storia di TM, esprimono
grandi riserve e spesso aperto discredito nei confronti dei
supposti benefici della TM/CAM.
9 I legislatori lottano con i problemi della sicurezza e
dell’efficacia dei fitoterapici tradizionali, mentre i consumatori
non vorrebbero alcun limite di accesso alle terapie di
TM/CAM.
9 Insieme alla domanda crescente di TM/CAM, è aumentata
anche quella di evidenze su:
•
•
•
sicurezza
efficacia
qualità dei prodotti e della pratica della TM/CAM
La necessità della ricerca scientifica
9 La grande diffusione della fitoterapia nei paesi industrializzati,
ove il modello medico-epistemologico prevalente è costituito dal
modello medico-scientifico, ha reso urgente il confronto
dell’immensa mole del patrimonio di conoscenze tradizionali
con le procedure di ricerca e validazione scientifiche, volte a
dimostrare la sicurezza e l’efficacia delle droghe singole o
associate in complessi in uso, talora, da millenni.
9 Per realizzare ciò, è importante un’attività congiunta di diverse
figure specialistiche che consentano di traslare l’uso, spesso
sicuro, delle ricette tradizionali all’interno delle società
industriali.
Revisione della letteratura sulla sicurezza e sull’efficacia
9 Una revisione della letteratura deve mostrare il livello attuale
di evidenza sulla sicurezza e sull’efficacia nell’uso di un
fitoterapico.
9 L’OMS ritiene che nuovi studi clinici dovrebbero essere
realizzati solo nei casi in cui l’uso tradizionale di una pianta
medicinale nell’uomo non abbia documentato con chiarezza la
sua sicurezza ed efficacia.
9 Se erbe medicinali, già conosciute, vengono riformulate in
nuove miscele, si deve tener conto dei requisiti di sicurezza ed
efficacia già definiti per ogni singola erba medicinale.
9 Comunque, non deve essere dimenticato che nuovi metodi di
preparazione possono alterare il profilo dei fitoterapici, usati
tradizionalmente, dal punto di vista chimico, tossicologico e
anche farmaceutico.
Sicurezza
9 Vanno tenuti in considerazione gli effetti collaterali segnalati e
documentati (registrati secondo i ben definiti principi di farmaco
vigilanza) di erbe, miscele di erbe, specie correlate, costituenti
dell’erba, loro preparazioni e prodotti finiti.
9 L’assenza di qualsiasi documentato effetto collaterale non costituisce
un’assoluta garanzia di sicurezza per i prodotti fitoterapici. Comunque
può non essere necessaria una serie completa di test tossicologici.
9 Sappiamo, però, che esistono effetti collaterali che sono difficili o
impossibili da determinare dal punto di vista clinico. Per questo
devono, comunque, essere completati test che valutino:
immunotossicità (per es. Test per reazioni allergiche) genotossicità,
carcinogenicità e tossicità sul sistema riproduttivo.
9 Solo nel caso non esista documentazione di un prolungato uso storico di
fitoterapici o quando esistano dubbi sulla loro sicurezza, si deve
procedere a studi aggiuntivi sulla loro tossicità.
Ricerca sull’uso tradizionale
Ricerca Clinica su Sicurezza ed Efficacia
Cure Primarie
Altre patologie
Ricerca Farmacologica su Sicurezza ed
Efficacia
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•
Wang WJ Prevention and treatment of metabolic syndrome with integrated
traditional Chinese and western medicine. Zhong Xi Yi Jie He Xue Bao. 2004
Sep;2(5):390-5.
Zhao HY Clinical observation on acupuncture for treatment of central obesity
Zhongguo Zhen Jiu. 2006 Sep;26(9):629-31.
Cabioğlu MT, Ergene N.Changes in levels of serum insulin, C-Peptide and glucose
after electroacupuncture and diet therapy in obese women. Am J Chin Med.
2006;34(3):367-76.
Lee MS, Hwan Kim J, Lim HJ, Shin BC. Effects of abdominal electroacupuncture on
parameters related to obesity in obese women: a pilot study. Complement Ther
Clin Pract. 2006 May;12(2):97-100. Epub 2006 Mar 23.
Cabioğlu MT, Ergene N.Electroacupuncture therapy for weight loss reduces serum
total cholesterol, triglycerides, and LDL cholesterol levels in obese women. Am J
Chin Med. 2005;33(4):525-33.
Qunli W, Zhicheng L. Acupuncture treatment of simple obesity. J Tradit Chin Med.
2005 Jun;25(2):90-4.
Hsu CH, Hwang KC, Chao CL, Chang HH, Chou P. Electroacupuncture in obese
women: a randomized, controlled pilot study. J Womens Health (Larchmt). 2005
Jun;14(5):434-40.
Liu XM, Zhang MM, Du L. Quality of methodology and reporting of randomized
controlled trials of acupuncture for obesity. Zhongguo Yi Xue Ke Xue Yuan Xue
Bao. 2004 Apr;26(2):192-4.
Obesità e Medicina Ayurvedica
•
Huang TH, Yang Q, Harada M, Uberai J, Radford J, Li GQ,
Yamahara J, Roufogalis BD, Li Y. Salacia oblonga root improves
cardiac lipid metabolism in Zucker diabetic fatty rats: modulation
of cardiac PPAR-alpha-mediated transcription of fatty acid
metabolic genes. Toxicol Appl Pharmacol. 2006 Jan 1;210(12):78-85. Epub 2005 Aug 29.
•
Bhatt AD, Dalal DG, Shah SJ, Joshi BA, Gajjar MN, Vaidya RA,
Vaidya AB, Antarkar DS. Conceptual and methodologic
challenges of assessing the short-term efficacy of Guggulu in
obesity: data emergent from a naturalistic clinical trial. J
Postgrad Med. 1995 Jan-Mar;41(1):5-7.
Depressione e MTC
•
Lee MS, Jang JW, Jang HS, Moon SR. Effects of Qi-therapy on blood
pressure, pain and psychological symptoms in the elderly: a
randomized controlled pilot trial. Complement Ther Med. 2003
Sep;11(3):159-64.
•
Eich H, Agelink MW, Lehmann E, Lemmer W, Klieser E. Acupuncture
in patients with minor depressive episodes and generalized anxiety.
Results of an experimental study. Fortschr Neurol Psychiatr. 2000
Mar;68(3):137-44.
•
Röschke J, Wolf C, Müller MJ, Wagner P, Mann K, Grözinger M, Bech
S.The benefit from whole body acupuncture in major depression. J
Affect Disord. 2000 Jan-Mar;57(1-3):73-81.
•
Akhondzadeh, S.; Noorbala, A. A.; Tahmacebi-Pour, N.; Kashani, L.
Crocus sativus L. in the treatment of mild to moderate depression: a
double-blind, randomized and placebo controlled trial. British Journal
of Clinical Pharmacology. 59(5):630, May 2005.
Depressione e Cure Primarie
•
Brown C., Abe-Kim J. S., Barrio C. Depression in Ethnically
Diverse Women: Implications for Treatment in Primary Care
Settings. Professional Psychology: Research and Practice
Copyright 2003 by the American Psychological Association, Inc.
2003, Vol. 34, No. 1, 10–19
Cancro e Medicina Ayurvedica
•
Marie Winters, ND. Ancient Medicine, Modern Use: Withania
somnifera and its Potential Role in Integrative Oncology.
Alternative Medicine Review, Volume 11, Number 4 – 2006
•
Subhash Chander Gangar, Rajat Sandhir, Durg Vijay Rai, Ashwani
Koul. Modulatory effects of Azadirachta indica on benzo(a)pyreneinduced forestomach tumorigenesis in mice. World J
Gastroenterol 2006 May 7;12(17):2749-2755
I PRINCIPALI CAMPI DI USO DELLA MTC NEL SETTORE
DELLA TERAPIA COMPLEMENTARE IN ONCOLOGIA 1/3
•
•
•
DOLORE
•
•
Correlato alla malattia tumorale
•
Correlato alla terapia antitumorale
•
Correlato a tecniche
terapeutiche invasive
•
Preanestesia e anestesia
diagnostico-
•
Agopuntura
•
Elettroagopuntura
•
Laser-terapia
•
Auricolo-terapia
•
Moxibustione
•
Fitoterapia
EDEMA
DISPNEA
•
•
•
Agopuntura
•
Laser-terapia sui punti di
agopuntura
•
Agopuntura
•
Ginnastiche Mediche
LEUCOCITOPENIA
•
Agopuntura e
Moxibustione
•
Agopuntura
•
Digitopressione
•
TENS
NAUSEA
SINTOMI VASOMOTORI
•
•
•
MOBILITA’ E RIABILITAZIONE
Agopuntura
QUALITA’ DELLA VITA
•
Agopuntura
•
Fitoterapia
•
Ginnastiche Mediche
•
•
SISTEMA IMMUNITARIO
•
Agopuntura
•
Moxibustione
ALTRI:
ALTRI
•
PERDITA DI PESO
XEROSTOMIA
•
Agopuntura
•
TERAPIA PER L’INTERRUZIONE DEL
FUMO O DELL’ALCOOL
•
Agopuntura
•
Fitoterapia
•
Moxibustione
ANORESSIA
PREVENZIONE:
PREVENZIONE
•
•
•
Agopuntura
•
Fitoterapia
•
Moxibustione
•
Qi Gong
TOSSE
•
Agopuntura
•
Laser-terapia
•
Agopuntura
•
Aghi a dimora
•
Fitoterapia
•
Agopuntura
•
Fitoterapia
•
Moxibustione
•
ASTENIA
•
•
•
STIPSI
•
Agopuntura
•
Fitoterapia
•
Dietetica
•
•
•
PARESI
•
Agopuntura
•
Fitoterapia
•
INCONTINENZA
Agopuntura
CATETERISMI
•
Agopuntura
•
Agopuntura
DISFAGIA
LESIONI DA DECUBITO
•
Agopuntura
•
Fitoterapia
•
Infrarossi
multipla
a
sorgente
•
Agopuntura
•
Agopuntura
•
Fitoterapia
•
Agopuntura
•
Fitoterapia
ITTERO
INSONNIA
•
•
•
DIARREA
Evidenze cliniche in MTC in PubMed 1/3
Citazione
Cancer and
acupuncture
Numero
negativi
fuori tema
64
8
14
49
1
2
Dal 2000 al
2005, con
abstract
86
Cancer and
CHM
positivi
Dal 2000 al
2005, con
abstract
52
Cancer and acupuncture
•
Anxiety
3
•
Breathlness/ dyspnea
2
•
Chronic orofacial pain
1
•
Clinical depression
3
•
Decrease of PSA
1
•
Distress
3
•
Edema
2
•
Fatigue
1
•
Fibromyalgia
1
•
Hot flashes
4
•
Immune system stimulation
3
•
Improve QOL
3
•
Improve the function of liver
1
•
Improvement of blood cells
1
•
Loss of appetite
1
•
Low urinary tract symptoms
1
•
Menopausa related symptoms
1
•
Nausea
•
Osteoporosis
1
•
Pain
9
•
Palliative cancer care
1
•
Recovery of intestinal function
1
•
Sweating
1
•
Throat diseases
1
•
Vasomotor symptoms
3
•
Vomiting
7
•
Xerosostomia
6
15
Cancer and CHM
•
Anti-angiogenesis
•
Anti-proliferative (blocking cancer
transformation, growth inibitory effects
on cancer, induce apoptosis)
27
•
Improving hepatic function after liver
carcinomectosomy
3
•
Increase of QOL
1
•
Lessening menopausal symptoms
1
•
Nausea- vomito
1
•
Ostalgia relieving
1
•
Preventing metastasis
1
•
Preventing myalgia
1
•
Recovery of hemopoietic function
1
•
Stomatitis
1
•
Survival rate
3
1
•
Arthritis
1
•
Blood leucocyte reduction
1
•
Body weight
1
•
Colon cancer chemoprevention
1
•
Hypnotic use
1
•
Hypocromic anemia
1
•
Immune enhancing effects
5
La ricerca
Studi sulle interazioni dei composti della CHM con Chemioterapici
•
Mitomycina C + Ginseng Î Effetto sinergico Matsuda H, Pharmacological study on
panax ginseng C. A. Meyer. XIV. Effect of 70% methanolic extract from red
ginseng on the cytocidal effect of mitomycin c against rat ascites hepatoma AH
130. [Yakugaku Zasshi. 1992 Nov:112 (11):846-55.]
•
Mitomycina C + Polyporus umbellatus Î Effetto sinergico [You Js, Comined
effects of chuling (Polyporous umbellatus) extract and mitomycin C on
experimental liver cancer, Am J Chin Med. 1994;22(1):19-28.]
•
Adriamycina + Baked Licorice Decoction Î Riduzione cardiotossicità [Ruizhi L., et
al. Utilizing Zhigancao Tang to relieve doxorubicin’s adverse effects, Chinese
Journal of Chinese Materia Medica. 1995:20(1):56-57.]
•
IL-2 + Astragalus membranaceus Î Potenziamento [Chu DT, The in vitro
potentiation of LAK cell cytotoxicity in cancer and AIDS patients induced by F3-a
fractionatextract of astragalus membranaceus. Chung Hua Chung LIU Tsa Chih.
1994. May:16(3):167-71].
•
Azathioprina + Ginseng Î Riduzione di efficacia [Shin HR, Kim JY, et al. The
cancer-preventive potential of Panax ginseng: a review of human and experimental
evidence. Cancer Causes Control 200,11:565-76]
La ricerca
Studi sulle interazioni dei composti della CHM con
Prodotti per il
sistema
cardiovascolare
Diuretici tiazidici
A
Liquirizia
Ipopotassiemia
Prodotti per il
sistema urogenitale e
gli ormoni sessuali
Contraccettivi orali
D
Ginseng
Controindicati in gravidanza
Terapia ormonale
sostitutiva
D
Liquirizia
Può interferire con i contraccettivi
orali perché ha attività modulante
ormonale
Trattamenti di
fecondazione assistita
D
Ginkgo
Può inibire la fecondazione
dell’ovocita
Fenitoina
D
Paeonia lactiflora
Può diminuire i livelli di fenitoina
e la sua efficacia terapeutica
Farmaci antidepressivi
IMAO
A
Arancio amaro
Può aumentare il rischio di effetti
collaterali con crisi ipertensive per
la presenza di sinefrina
Prodotti per il
sistema nervoso
centrale
La ricerca
Studi sulle interazioni dei composti della CHM con Citocromi
•
Paeonia lactiflora induce P450-2C9 (antiepilettici)
•
Ginseng inibisce P450-2D6 (antidepressivi triciclici)
•
Liquirizia inibisce P450-3A4 (Lovastatina, Triazolam, Ketoconazolo)
Allergie
3
Artiglio del
diavolo
TrM
Harpagophytum
procumbens
Centella
TrM
Centella asiatica
Elicriso
TrM
Helicrysum
angustifolium
Liquirizia
TrM
PhR
Glycyrrhiza glabra
Piantaggine
TrM
PhR
Plantago lanceolata,
Plantago major
Schisandra
TrM
Schisandra sinensis
Allergie - Liquirizia
•
Lee YM, Hirota S, Jippo-Kanemoto T, Kim HR, Shin TY, Yeom Y, Lee KK,
Kitamura Y, Nomura S, Kim HM. Inhibition of histamine synthesis by
glycyrrhetinic acid in mast cells cocultured with Swiss 3T3 fibroblasts. Int
Arch Allergy Immunol. 1996 Jul;110(3):272-7.
Allergie - Piantaggine
•
Ikawati Z, Wahyuono S, Maeyama K. Screening of several Indonesian
medicinal plants for their inhibitory effect on histamine release from RBL2H3 cells. J Ethnopharmacol. 2001 May; 75(2-3):249-56.
Anemia
3
Angelica
cinese
TrM PhR
Angelica sinensis
Equiseto
TrM
Equisetum arvense
Fieno Greco
TrM
Trigonella foenum
graecum
Genziana
TrM
Gentiana lTrMea
Ortica, Foglie
TrM
Urtica dioica
Anemia - Angelica cinese
•
Ma LF et al. The effect of Angelica sinensis polysaccharides on
mouse bone marrow hematopoiesis. Zhonghua Xinxueguanbing
Zazhi, 1988, 9:148-149.
•
Chen YC, Gao YQ. Research on the mechanism of blood-tonifying
effect of danggui buxue decoction. Chung Kuo Chung Yao Tsa
Chih, 1994, 19:43-45, 63.
•
Wang Y, Zhu B. The effect of Angelica polysaccharide on
proliferation and differentiation of hematopoietic progenitor cells.
Chung Hua I Hsueh Tsa Chih, 1996, 76:363-366.
Angina
pectoris
2
Biancospino
1 Astragalo
TrM
PhR Crataegus oxyacantha
ClR TrM
Astragalus
membranaceus
Angina pectoris - Biancospino
•
Schussler M, Holzl J, Rump AFE, Fricke U: Functional and anti- ischemic effects
of monoacetyl-vitexinrhamnoside in different in vitro models. Gen Pharmacol
26:1565-1570, 1995.
•
Chen ZY, Zhang ZS, Kwan KY, et al: Endothelium-dependent relaxation by
hawthorn extract in rat mesenteric artery. Life Sci 63:1983-1991, 1998.
•
Schwinger RHG, Pietsch M, Frank K, Brixius K: Crataegus spezial extract WS
1442 increases force of contraction in human myocardium cAMP indipendently. J
Cardiovasc Pharmacol 35:700-707, 2000.
•
Muller A, Linke W, Klaus W: Cratageus extract blocks potassium currents in
guinea pig ventricular cardiac myocytes. Planta Med 65:335-339,1999.
•
Ammon HPT, Kaul R. Crataegus, Herz-Kreislauf-Wirkungen von
Crataegusextrakten, Flavonoiden und Procyanidinen. Teil 1: Historisches und
Wirkstoffe. Deutsche Apotheker Zeitung, 1994, 134:2433–-2436.
•
Costa R et al. Étude comparée de l’activité cardiovasculaire des jeunes pousses,
des feuilles et des fleurs de Crataegus oxyacantha L. III. Action protectrice sur le
cœur isolés de rat vis-à-vis des agents arythmogènes et dans les arythmies par
reperfusions. Plantes médicinales et Phytothérapie, 1986, 20:115–-128.
•
Occhiuto F et al. Étude comparée de l’activité cardiovasculaire des jeunes
pousses, des feuilles et des fleurs de Crataegus oxyacantha L. I. Activité
electrique et tension arterielle chez le rat. Plantes médicinales et Phytothérapie,
1986, 20:37-–51.
Angina pectoris - Biancospino
•
Popping S, Rose I, Ionescu Y, et al: Effect of a hawthorn extract on contraction and energy
turnover of isolated rat cardiomyocytes. Arzneim-Forsch/Drug Res 45:1157-1161, 1995.
•
Muller A, Linke W, Zhao Y, Klaus W: Cratageus extract prolongs action potential duration in
guinea-pig papillary muscle. Phytomed 3:257-261, 1996
•
Nasa Y et al. Protective effect of Crataegus extract on the cardiac mechanical dysfunction in
isolated perfused working rat heart. Arzneimittel-Forschung, 1993, 43:945–-949.
•
Chatterjee SS et al. In vitro und in vivo-Untersuchungen zur kardioprotektiven Wirkung von
oligomeren Procyanidinen in einem Crataegus-Extrakt aus Blättern mit Blüten. ArzneimittelForschung, 1997, 47:821–-825.
•
Krzeminski T, Chatterjee SS. Ischemia and early reperfusion-induced arrhythmias: beneficial
effects of an extract of Crataegus oxyacantha L. Pharmacy and Pharmacological Letters, 1993,
3:45–-48.
•
Mävers WH, Hensel H. Veränderungen der lokalen Myokarddurchblutung nach oraler Gabe
eines Crataegus-Extraktes bei nichtnarkotisierten Hunden. Arzneimittel-Forschung, 1974,
24:783–-785.
•
Roddewig C, Hensel H. Reaktion der lokalen Myokarddurchblutung von wachen Hunden und
narkotisierten Katzen auf orale und parenterale Applikation einer Crataegus Fraktion
(oligomere Procyanidine). Arzneimittel-Forschung, 1977, 27:1407–-1410.
•
Chatterjee SS, Koch E, Jaggy H, Krzeminski T: In vitro and in vivo investigations on the
cardioprotective effects of oligomeric procyanidins in a Crataegus extract from leaves with
flowers. Arzneim-Forsch/Drug Res 47:821-825, 1997.
Angina pectoris - Astragalo
•
Miller AL. Botanical influences on cardiovascular disease. Altern Med Rev.
1998 Dec;3(6):422-31. Review.
•
Chen LX, Liao JZ, Guo WQ. Effects of Astragalus membranaceus on left
ventricular function and oxygen free radical in acute myocardial infarction
patients and mechanism of its cardiotonic action. Chung Kuo Chung His I
Chieh Ho Tsa Chih 1995;15:141-143.
•
Lei ZY, Qin H, Liao JZ. Action of Astragalus membranaceus on left
ventricular function of angina pectoris. Chung Kuo Chung His I Chieh Ho
Tsa Chih 1994;14:195,199-202.
•
Li SQ, Yuan RX, Gao H. Clinical observation on the treatment of ischemic
heart disease with Astragalus membranaceus. Chung Kuo Chung His I
Chieh Ho Tsa Chih 1995;15:77-80.
Ansia
2
Avena
TrM
Avena sativa
Biancospino
TrM
Crataegus oxyacantha
Centella
ClR
Cimicifuga
TrM
Iperico
TrM
ClR Hypericum perforatum
Luppolo
PhR
TrM
Meliloto
TrM
Melissa
ClR +
PhR
TrM
Melissa officinalis
Passiflora
ClR
TrM
Passiflora incarnata
Primula, Fiori
TrM
Primula veris
Rodiola
TrM
Rhodiola rosea
Salice
TrM
Salix alba
Valeriana
ClR
Withania
TrM
PhR Centella asiatica
Cimicifuga racemosa
Humulus lupulus
Melilotus officinalis
TrM
Valeriana officinalis
Withania somnifera
Ansia - Centella
•
Bradwejn J, Zhou Y, Koszycki D, Shilk J: A double-blind, placebocontrolled study on the effects of Gotu Kola (Centella asiatica) on
acoustic startle response in healthy subjects. J Clin Psychopharmacol
20:680-684, 2000.
Ansia - Iperico
•
Kumar V, Jaiswal AK, Singh PN, Bhattacharya SK. Anxiolytic activity of
Indian Hypericum perforatum Linn: an experimental study. Indian J Exp Biol
2000; 38:36-41
Ansia - Luppolo
•
Wohlfart R, Hansel R, Schmidt H. The sedative-hypnotic action of
hops. Pharmacology of the hop substance 2-methyl-3-buten-2-ol.
Planta Med. 1983 Jun;48(2):120-3.
•
Wohlfart R, Wurm G, Hansel R, Schmidt H. Detection of sedativehypnotic active ingredients in hops. 5. Degradation of bitter acids
to 2-methyl-3-buten-2-ol, a hop constituent with sedative-hypnotic
activity. Arch Pharm (Weinheim). 1983;316(2):132-7.
Ansia - Melissa
•
Cerny A, Schmid K: Tolerability and efficacy of valerian/lemon balm in
healthy volunteers (a double-blind, placebo-controlled, multicentre
study). Fitoterapia 70:221-228, 1999.
• Dressing H, Riemann D, Low H, et al: Insomnia: Are valerian/balm
combinations of equal value to benzodiazepine? Therapiewoche
42:726-736,1992.
• Soulimani R, Fleurentin J, Mortier F, et al: Neurotropic action of the
hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med
57:105-109, 1991.
Ansia - Passiflora
•
Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rachidi H,
Khani M. Passionflower in the treatment of generalized anxiety: a pilot
double-blind randomized controlled trial with oxazepam. J Clin Phar
Ther. 2001 Oct; 26 (5):363-367.
Ansia - Valeriana
•
Cropley M, Cave Z, Ellis J, Middleton RW. Effect of kava and valerian
on human physiological and psychological responses to mental stress
assessed under laboratory conditions. Phytother Res 2002;16:23-7.
• Kohnen R, Oswald WD. The effects of valerian, propanolol, and their
combination on activation, performance and mood of healthy volunteers
under social stress conditions. Pharmacopsychiatry 1988; 21:447-8.
• Andreatini R, Sartori VA, Seabra ML, Leite JR. Effect of valepotriates
(valerian extract) in generalized anxiety disorder: a randomized
placebo-controlled pilot study. Phytother Res 2002; 16:650-4.
Artrite
1
Artiglio del diavolo
ClR
TrM
2
Astragalo
TrM
Boswellia
ClR
Echinacea a.
TrM
Echinacea angustifolia
Ortica, Foglie
TrM
Urtica dioica
Ortica, Parti aeree
ClR
TrM
Urtica dioica
Salice
ClR
TrM
Salix alba
Sambuco
TrM
Sambucus nigra
Withania
TrM
Withania somnifera
Zenzero
ClR
Harpagophytum procumbens
Astragalus membranaceus
TrM
TrM
Boswellia serrata
Zingiber officinalis
Artrite – Artiglio del diavolo
•
Leblan D, Chantre P, Fournie B. Harpagpphytum procumbens in the
treatment of knee and hip osteoarthritis. Four-month results of a
prospective, multicenter, double-blind trial versus diacerhein. Joint
Bone Spine 67:462-467, 2000.
• Wegener T: Devil’s claw From African traditional remedy to modern
analgesic and anti-infiammatory. HerbalGram 50 47-54, 2000.
• Ernst E, Chrubasik S. Phyto-anti-inflammatories: A systematic review of
randomized, placebo-controlled, double-blind trials. Rheum Dis Clin
North Am 26:13-27, 2000.
Artrite – Boswellia
•
Atal, CK et al. Salai guggal ex-Boswellia serrata. A promising
antihyperlipidemic and antiarthritic agent. lndian Journal of
Pharmacology, 1980, 12: 59A.
Artrite – Ortica
•
Chrubasik S, Enderlein W, Bauer R, Grabner W: Evidence for
antirheumatic effectiveness of herba Urticae dioicae in acute arthritis: A
pilot study. Phytomed 4:105-108,1997.
Artrite – Salice
•
•
Schmid B et al. Efficacy and tolerability of a standardized willow bark
extract in patients with osteoarthritis: randomized placebo controlled,
double-blind clinical trial. Phytother Res 2001;15:344-50.
Mills SY et al. Effect of a proprietary herbal medicine on the relief of
chronic arthritic pain: A double-blind study. British Journal of
Rheumatology, 1996, 35:874-878.
Artrite – Zenzero
•
•
•
Altman RD, Marcussen KC. Effects of ginger extract on knee pain in
patients with osteoarthritis. Arthritis Rheum 2001;44:2531-38.
Marcus DM, Suarez-Almazor ME. Is there a role for ginger in the
treatment of osteoarthritis? Arthritis Rheum 2001;44:2461-2.
Bliddal H, Rosetzsky A, Schlichting P, et al. A randomized, placebocontrolled, cross-over study of ginger extracts and ibuprofen in
osteoarthritis. Osteoarth Cartilage 2000;8:9-12.
Artrosi
Artrosi, Uso
esterno
2
2
Artiglio del
diavolo
ClR
TrM
Bardana
TrM
Arctium lappa
Betulla
TrM
Betula alba
Curcuma
PhR
Curcuma longa
Equiseto
TrM
Equisetum arvense
Verga d'oro
TrM
Solidago virgaurea
Vischio
TrM
Viscum album
Borsa pastore
TrM
Capsella Bursa pastoris
Eucalipto
TrM
Eucalyptus globulus
Fieno Greco
TrM
Trigonella foenum graecum
Harpagophytum procumbens
Artrosi – Artiglio del diavolo
•
Leblan D, Chantre P, Fournie B. Harpagpphytum procumbens in the
treatment of knee and hip osteoarthritis. Four-month results of a
prospective, multicenter, double-blind trial versus diacerhein. Joint
Bone Spine 67:462-467, 2000.
• Wegener T: Devil’s claw From African traditional remedy to modern
analgesic and anti-infiammatory. HerbalGram 50 47-54, 2000.
• Ernst E, Chrubasik S. Phyto-anti-inflammatories: A systematic review of
randomized, placebo-controlled, double-blind trials. Rheum Dis Clin
North Am 26:13-27, 2000.
Artrosi – Curcuma
•
•
•
•
•
•
Arora RB et al. Anti-inflammatory studies on Curcuma longa (turmeric). Indian
journal of medical research, 1971, 59:1289–1295.
Yegnanarayan R, Saraf AP, Balwani JH. Comparison of antiinflammatory
activity of various extracts of Curcuma longa (Linn). Indian journal of medical
research, 1976, 64:601–608.
Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta medica, 1991,
57:1– 7.
Kunchandy E, Rao MN. Oxygen radical scavenging activity of curcumin.
International journal of pharmacognosy, 1990, 58:237–240.
Ammon HP, Anazodo MI, Safayhhi H, Dhawan BN, Srimal RC. 1992.
Curcumin: a potent inhibitor of leukotriene B4 formation in rat peritoneral
polymorphonuclear neutrophils. Planta Med 58(2):226.
Duke, J.A. 1999. Clippings from my COX box. Journal of Medicinal Food
1(4):293-298.
Asma
1
Boswellia
ClR
TrM
Desmodium
TrM
Desmodium adscendens
Elicriso
TrM
Helicrysum angustifolium
Ginkgo
TrM
Ginkgo biloba
Liquirizia
PhR
Withania
TrM
Boswellia serrata
TrM Glycyrrhiza glabra
Withania somnifera
Asma – Boswellia
•
•
Gupta I, Gupta V, Parihar A et al., Effect of Boswellia gum resin in
patients with bronchial asthma: results of a double-blind, placebocontrolled, 6-week clinical study, Eur: J: Med Res., 3(11):511-4,1998.
Miller AL, The etiologies, pathophysiology, and
alternative/complementary treatment of inhibitor of leukotriene
biosynthesis, Eur: J. Med. Res., 1(8):369-70, 2001.
Asma – Liquirizia
•
Anderson DM, Smith WG. The antitussive activity of glycyrrhetinic acid
and its derivatives. J Pharm Pharmacol. 1961 Jul;13:396-404.
Bronchite
Bronchite
cronica
1
2
Altea
PhR
TrM
Elicriso
TrM
Eucalipto
ClR
Liquirizia
TrM
Glycyrrhiza glabra
Piantaggine
TrM
Plantago lanceolata, Plantago
major
Primula, Rizoma
TrM
Primula veris
Sambuco
ClR
Timo
TrM
Thymus vulgaris
Aglio
TrM
Allium sativum
Angelica
arcangelica
TrM
Angelica archangelica
Bardana
TrM
Arctium lappa
Boswellia
TrM
Boswellia serrata
Eucalipto
ClR
Ganoderma
TrM
Althea officinalis
TrM
TrM
TrM
Eucalyptus globulus
Sambucus nigra
Eucalyptus globulus
Ganoderma lucidum
Bronchite – Altea
•
Nosal’ova G et al. Antitussive efficacy of the complex extract and the
polysaccharide of marshmallow (Althaea officinalis L. var. Robusta).
Pharmazie, 1992, 47:224–226.
Bronchite – Eucalipto
•
Nosal’ova G et al. Antitussive efficacy of the complex extract and the
polysaccharide of marshmallow (Althaea officinalis L. var. Robusta).
Pharmazie, 1992, 47:224–226.
Bronchite – Sambuco
• Marz RW, Mallhys H: Phytomedicines in the treatment of the lower
respiratory tract. What is proven? In Loew D, Rielbrock N (eds):
Phytopharmaka 111. Forschung und klinische Anwendung. Darmstadt,
Germany, Steinkopff Verlag, 1997, pp 161-178.
Bronchite cronica – Eucalipto
•
•
Burrow, A, R. Eccles, A.S. Jones. 1983. The effects of camphor,
eucalyptus and menthol vapour on nasal resistance to airflow and nasal
sensation. Acta Otolaryngol (stockh) 96(1-2):157-161.
Whitmen, B.W and H. Ghazizadeh. 1994. Eucalyptus oil: therapeutic
and toxic aspects of pharmacology in humans and animals. J Paediatr
Child Health 30(2):190-191.
Cardiopatia, 1 Aglio
coadiuvante
Astragalo
e come
prevenzione
Avena
Biancospino
ClR
ClR
Allium sativum
TrM
ClR
PhR
Astragalus
membranaceus
Avena sativa
TrM
Crataegus
oxyacantha
Cardiopatia – Aglio
•
Kiesewetter H et al. Effect of garlic on platelet aggregation in patients
with increased risk of juvenile ischaemic attack. European journal of
clinical pharmacology, 1993, 45:333-336.
Cardiopatia – Astragalo
•
•
•
•
Miller AL. Botanical influences on cardiovascular disease. Altern Med
Rev. 1998 Dec;3(6):422-31. Review.
Chen LX, Liao JZ, Guo WQ. Effects of Astragalus membranaceus on
left ventricular function and oxygen free radical in acute myocardial
infarction patients and mechanism of its cardiotonic action. Chung Kuo
Chung His I Chieh Ho Tsa Chih 1995;15:141-143.
Lei ZY, Qin H, Liao JZ. Action of Astragalus membranaceus on left
ventricular function of angina pectoris. Chung Kuo Chung His I Chieh
Ho Tsa Chih 1994;14:195,199-202.
Li SQ, Yuan RX, Gao H. Clinical observation on the treatment of
ischemic heart disease with Astragalus membranaceus. Chung Kuo
Chung His I Chieh Ho Tsa Chih 1995;15:77-80.
Cardiopatia – Avena
•
•
•
•
•
•
•
•
•
Ludwig DS, Pereira MA, Kroenke CH, et al. Dietary fiber, weight gain, and
cardiovascular disease risk factors in young adults. JAMA 1999;282:1539-46
FDA Talk Paper. FDA Allows Whole Oat Foods to make Claim on Reducing the
Risk of Heart Disease. 1997. Available at: vm.cfsan.fda.gov/~lrd/tpoats.html.
Pietinen P, Rimm EB, Korhonen P, et al. Intake of dietary fiber and risk of
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Van Horn L. Fiber, lipids, and coronary heart disease. A statement for
healthcare professionals from the Nutr Committee, Am Heart Assn. Circulation
1997;95:2701-4.
Rimm EB, Ascherio A, Giovannucci E, et al. Vegetable, fruit, and cereal fiber
intake and risk of coronary heart disease among men. JAMA 1996;275:447-51.
He J, Klag MJ, Whelton PK, et al. Oats and buckwheat intakes and
cardiovascular disease risk factors in an ethnic minority of China. Am J Clin Nutr
1995;61:366-72.
Khaw KT, Barrett-Connor E. Dietary fiber and reduced ischemic heart disease
mortality rates in men and women: a 12-year prospective study. Am J Epidemiol
1987;126:1093-102
Morris JN, Marr JW, Clayton DG. Diet and heart: a postscript. Br Med J
1977;2:1307-14
Kromhout D, de Lezenne C, Coulander C. Diet, prevalence and 10-year
mortality from coronary heart disease in 871 middle-aged men. The Zutphen
Study. Am J Epidemiol 1984;119:733-41
Claudicatio
intermittens
1
Ginkgo
ClR
TrM
Ginkgo biloba
Pittler MH, Ernst E. Ginkgo biloba extract for the treatment of
intermittent claudication: A meta-analysis of randomized trials. Am
J Med 108:276-281, 2000.
Colite ulcerosa
1
Colite ulcerosa
per enteroclismi,
Uso esterno
Colon irritabile
3
Aloe
ClR
TrM
Aloe vera
Boswellia
ClR
TrM
Boswellia serrata
Psillio bianco
ClR
TrM
Plantago ovata, Plantago
ispaghula
Camomilla
TrM
Matricaria chamomilla
Achillea
TrM
Achillea millefolium
Altea
TrM
Althea officinalis
Carciofo
ClR
Cynara scolymus
Ficodindia
TrM
Opuntia ficus indica
Meliloto
TrM
Mirtillo, Frutti
TrM
Vaccinium myrtillus
Ortica, Foglie
TrM
Urtica dioica
Psillio bianco
ClR
Psillio nero
TrM
Plantago afra, Plantago indica
Rabarbaro, a
basso dosaggio
TrM
Rheum palmatum
TrM
ispaghula
Colite ulcerosa – Aloe
•
•
Langmead L, Feakins RM, Goldthorpe S, et al. Randomized, doubleblind, placebo-controlled trial of oral aloe vera gel for active ulcerative
colitis. Aliment Pharmacol Ther 2004;19:739-47.
Langmead L, Makins RJ, Rampton DS. Anti-inflammatory effects of
aloe vera gel in human colorectal mucosa in vitro. Aliment Pharmacol
Ther 2004;19:521-7.
Colite ulcerosa – Boswellia
•
Gupta, I et al. Effects of Boswellia serrata gum resin in patients with
ulcerative colitis. European Journal of Medical Research, 1997, 21:3743.
Colite ulcerosa – Psillio bianco
•
•
Fernandez-Banares F, Hinojosa J, Sanchez-Lombrana JL, Navarro E,
Martinez-Salmeron JF, Garcia-Puges A, Gonzalez-Huix F, Riera J,
Gonzalez-Lara V, Dominguez-Abascal F, Gine JJ, Moles J, Gomollon
F, Gassull MA. Randomized clinical trial of Plantago ovata seeds
(dietary fiber) as compared with mesalazine in maintaining remission in
ulcerative colitis. Spanish Group for the Study of Crohn's Disease and
Ulcerative Colitis (GETECCU). Am J Gastroenterol. 1999 Feb;
94(2):427-33.
Hallert C, Kaldma M, Petersson BG. Ispaghula husk may relieve
gastrointestinal symptoms in ulcerative colitis in remission. Scand J
Gastroenterol. 1991 Jul; 26(7):747-50.
Colon irritabile – Carciofo
•
Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract
reduces symptoms of irritable bowel syndrome in a post-marketing
surveillance study. Phytotherapy Research, 2001, 15:58-61.
Colon irritabile – Psillio bianco
•
Jalihal A, Kurian G. Ispaghula therapy in irritable bowel syndrome: improvement in
overall well-being is related to reduction in bowel dissatisfaction. J Gastroenterol
Hepatol. 1990 Sep-Oct; 5(5):507-13.
•
Prior A, Whorwell PJ. Double blind study of ispaghula in irritable bowel syndrome.
Gut. 1987 Nov; 28(11):1510-3.
•
Kumar A, Kumar N, Vij JC, Sarin SK, Anand BS. Optimum dosage of ispaghula
husk in patients with irritable bowel syndrome: correlation of symptom relief with
whole gut transit time and stool weight. Gut. 1987 Feb; 28(2):150-5.
•
Misra SP, Thorat VK, Sachdev GK, Anand BS. Long-term treatment of irritable
bowel syndrome: results of a randomized controlled trial. Q J Med. 1989 Oct;
73(270):931-9.
Coronaropatia,
come
coadiuvante
1
Tribolo
ClR
Deficit cognitivo
2
Centella
ClR
TrM
Centella asiatica
Ginseng
ClR
TrM
Panax ginseng
Degenerazione
maculare
2
Ginkgo
ClR
Demenza senile
2
Ginkgo
ClR
Tribulus terrestris
Ginkgo biloba
TrM
Ginkgo biloba
Coronaropatia – Tribolo
•
Wang B, Ma L, Liu T. 406 cases of angina pectoris in
coronary heart disease treated with saponin of Tribulus
terrestris. ZhongXi Yi JieHe Za Zhi, 1990, 10:85-87. .
Deficit cognitivo – Centella
•
•
Appa Rao MVR, Srinivasan K, Koteswara RTL: The effects of
Centella asiatica on the general ability of mentally retarded
children. Ind J Psych 19:54-59, 1977.
Chittaranjan A, Sudha S, Venkataraman BV: Herbal treatments for
ECS-induced memory deficits: A review of research and a
discussion on animal models. J ECT 16:145-156, 2000..
Deficit cognitivo – Ginseng
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a double blind pharmacological trial on two domains of wellbeing in subjects wlth age assocìated memory impairment
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• Thommessen B, Laake K. No identìficable effect of ginseng
(Gericomplex) as an adjuvant in the treatment of geriatrìc
patients. Aging Clin Exp Res 1996; 8:417-420.
Degenerazione maculare – Ginkgo
•
Chavez ML, Chavez PI. Ginkgo (part 2): Clinical efficacy,
dosage, and adverse effects. Hosp Pharm 33:10761095,1998. .
Demenza senile – Ginkgo
•
•
•
•
Oken BS, Storzbach DM, Kaye JA. The efficacy of Ginkgo bì/oba on
cognitive function in Alzheimer's disease. Arch Neurol 55:1409-1415,
1998.
Ernst E, Pittler MH. Ginkgo biloba for dementia: A systematic review of
double-blind, placebo-controlled trials. Clio Drug Invest 17:301-308,
1999.
Oken BS, Storzbach DM, Kaye JA. The efficacy of Ginkgo bìloba on
cognitive function in Alzheimer's disease. Arch Neurol 55:1409-1415,
1998.
van Dongen MCJM, van Rossum E, Kessels AGH, et al. The efficacy of
Ginkgo for elderly people with dementia and age-associated memory
impairment: New results of a randomized clìnical trial. J Am Geriatr Soc
48: 1183-1194, 2000
Depressione
1
Angelica
arcangelica
TrM
Angelica
archangelica
Eleuterococco
TrM
Eleutherococcus
senticosus
Ginkgo
ClR
Ginkgo biloba
Ginseng
ClR
Tr
M
Panax ginseng
Iperico
ClR1
ClR2
ClR3
Tr
M
Hypericum
perforatum
Rodiola
TrM
Rhodiola rosea
Depressione – Ginkgo
•
Chavez ML, Chavez PI. Ginkgo (part 2): Clinical efficacy,
dosage, and adverse effects. Hosp Pharm 33:1076-1095,1998
Depressione menopausale – Ginseng
•
Wiklund IK, Mattsson LA, Lindgran R, Limoni C ( 1999). Effects
of a standardized ginseng extract on quality of lire and
physiological parameters in symptomatic postmenopausal
women: A double-blind, placebo-controlled trial. International
Joumal of Clinical Pharmacology Research 19 (3): 89-99.
Depressione – Iperico - 1
•
Linde K, Ramirez G, Mulrow CD, et al. St. John’s wort for
depression – An overview and meta-analysis of randomized
clinical trials. BMJ 1996; 313:253-258.
•
Linde K, Mulrow CD. St. John’s wort for depression (Cochrane
Review). In The Cochrane Library. Issue 4. Oxford, Update
Software, 2000.
•
Ernst E. St John’s wort, an antidepressant? A systematic, criteriabased review. Phytomedicine, 1995, 2:67-71.
•
Vorbach EU, Arnoldt KH, Hübner W-D. Efficacy and tolerability of
St John’s wort extract LI 160 versus imipramine in patients with
severe depressive episodes according to ICD-10.
Pharmacopsychiatry, 1997, 30:81-85.
•
Harrer G, Schmidt U, Kuhn U, Biller A. Comparison of equivalence
between the St. John's wort extract LoHyp-57 and fluoxetine.
Arzneim-Forsch/Drug Res 1999;49:289-296.
•
•
•
•
•
Schrader E, on behalf of the Study Group. Equivalence of St John's
wort extract (ZE 117) and fluoxetine: a randomized, controlled study
in mild-moderate depression. Int Clin Psychopharmacol 2000;
15:61-68.
Brenner R, Azbel V, Madhusoodanan S, Pawlowska M.
Comparison af an extract of Hypericum (LI 160) and sertraline in
the treatment of depression: A double-blind, randomized pilot study.
Clio Ther 2000; 22:411-419
Schellenberg R et al. Pharmacodynamic effects of two different
Hypericum extracts in healthy volunteers measured by quantitative
EEG. Pharmacopsychiatry, 1998, 31 (Suppl. 1):S44-S53.
Johnson D. Neurophysiologische Wirkungen von Hypericum im
Doppelblindversuch mit Probanden. Nervenheilkunde, 1991,
10:316-317.
Johnson D et al. Effects of Hypericum extract LI 160 compared with
maprotiline on resting EEG and evoked potentials in 24 volunteers.
Journal of Geriatric Psychiatry and Neurology, 1994, 7 (Suppl.
1):S44-S46.
•
Martinez B et al. Hypericum in the treatment of seasonal affective
disorders. Journal of Geriatric Psychiatry and Neurology, 1994, 7
(Suppl. 1):S29-S33.
•
Kasper S. Treatment of seasonal affective disorder (SAD) with
Hypericum extract. Pharmacopsychiatry, 1997, 30 (Suppl. 1):S89S93.
•
Schempp CM, Winghofer B, Langheinrich M, et al. Hypericin levels
in human serum and interstitial skin blister fluid after oral singledose and steady state administration of Hypericum perforatum
extract (St. John's Wort). Skin Pharmacol Appl Skin Physiol 1999;
12:299-304.
•
Wilhelm KP, Biel S, Siegers CP. Role of flavonoids in controlling
the phy?ototoxicity of Hypericum perforatum extracts.
Phytomedicine 2001; 8:306-9.
Dermatite
3
Dermatite seborroica,
Uso esterno
3
Dermatite, Uso
esterno
3
Aloe
TrM
Bardana
PhR
Centella
TrM
Centella asiatica
Elicriso
TrM
Fumaria
TrM
Fumaria officinalis
Piantaggine
TrM
Plantago lanceolata, Plantago major
Sambuco
TrM
Sambucus nigra
Withania
TrM
Withania somnifera
Aloe
ClR
Aloe vera
Avena
TrM
Avena sativa
Aloe
ClR
TrM
Aloe vera
Amamelide
ClR
TrM
Hamamelis virginiana
Calendula
TrM
Calendula officinalis
Camomilla
TrM
Echinacea a.
TrM
Echinacea p.
TrM
Echinacea purpurea
Piantaggine
TrM
Primula, Rizoma
TrM
Primula veris
Aloe vera
TrM
Arctium lappa
Dermatite – Bardana
•
Kardosova A, Ebringerova A, Alfoldi J, et al. A biologically active
fructan from the roots of Arctium lappa L., var. Herkules. Int J Biol
Macromol 2003;33:135-40.
Dermatite seborroica – Aloe
•
•
•
•
•
•
Vardy DA, Cohen AD, Tchetov T, et al: A double-blind, placebocontrolled trial of an Aloevera (A. barbadensis) emulsion in the
treatment of seborrheic dermatitis. J Dermatol Treat 10:7-11,1999.
Syed TA, Ahmad SA. Holt AH, et al: Management of psoriasis with
Aloe vera extract in a hydrophilic cream: A placebo-controlled,
double-blind study. Trop Med loti Health 1 :505-509, 1996.
Syed TA, Cheema KM, Ahmad SA, Holt AH: Aloe vera extract 0.5%
in hydrophilic cream versus aloe vera gel far the management of
genital herpes in males. A placebo-controlled, double-blind,
comparative study. J Eur Acad Dermatol Venereo I7:294-295, 1996.
Syed TA, Afzal M, Ahmad SA, et al: Management of genital herpes
in men with 0.5% Aloe vera extract in hydrophilic cream: A placebocontrolled double-blind study. J Dermatol Treat 8:99-102, 1997.
Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical
effectiveness. Br J Gen Pract 1999;49:823-8.
Syed TA, Ahmad SA, Holt AH, et al. Management of psoriasis with
Aloe vera extract in a hydrophilic cream: a placebo-controlled,
double-blind study. Trop Med Int Health 1996;1:505–9.
Dermatite, uso esterno – Aloe
•
Vogler BK, Ernst E: Aloe vera: A systematic review of its clinical
effectiveness. Br J Gen Pract 49:823-828, 1999 .
Dermatite, uso esterno – Amamelide
•
•
•
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Pfister R. Zur Problematik der Behandlung und Nachbehandlung
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Swoboda M, Meurer J. Therapie von Neurodermitis mit Hamamelis
virginiana Extrakt in Salbenform. Zeitschrift für Phytotherapie, 1991,
12:114–117.
Wokalek H. Zur Bedeutung epidermaler Lipide und des
Arachidonsäurestoff wechsels bei feuilles d’hamamelis. Journal de
Pharmacie de Belgique, 1993, 27: 498–506.
Diabete,
come
coadiuvante
1
1
Bardana
TrM
Fieno Greco
ClR
Aloe
ClR
Aloe vera
Astragalo
TrM
Astragalus
membranaceus
Avena
ClR
Avena sativa
Ganoderma
TrM
Ganoderma lucidum
Ginseng
ClR
Psillio
bianco
Cl1
ClR2
ClR3
Plantago ovata,
Plantago ispaghula
Withania
TrM
Withania somnifera
Arctium lappa
TrM
TrM
Trigonella foenum
graecum
Panax ginseng
Diabete – Fieno greco
•
•
•
•
•
•
•
Mazdar Z, Abel R, Samish S, Arad J. Glucose-lowering effect of fenugreek
in noninsulin-dependent diabetics. Eur J Clin Nutr 42:51-54, 1988.
Sharma RD. Effect of fenugreek seeds and leaves on blood glucose and
serum insulin responses in human subjects. Nutr Res 6: 1353-1364, 1986.
Raghuram TC, Sharma RD, Sivakumar B. Effect of fenugreek seeds on
intravenous glucose disposition in noninsulin-dependent diabetic patients.
Phytother Res 8:83-86, 1994.
Sharma RD, Raghuram TC, Rao SN. Effect of fenugreek seeds on blood
glucose and serum lipids in type I diabetes. Europ J Clin Nutr 44: 301-306,
1990.
Sharma RD, Sarkar A, Hazra DK, et al. Use of fenugreek seed powder in
the management of noninsulin-dependent diabetes mellitus. Nutr Res 16:
1331-1339,1996.
Kumar N, Kumar A, Sharma ML. Clinical evaluation of single and herbomineral compound drugs in the management of Madhumeha (diabetes). J
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blood lipids, blood sugar and platelet aggregation in patients with coronary
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Diabete – Aloe
•
Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V,
Chokechai-jaroenparn O: Antidiabetic activity af Aloe vera L. juice.
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Diabete – Avena
•
•
•
.
Pick ME, Hawrysh ZJ, Gee MI, et al. Oat bran concentrate bread
products improve long-term control of diabetes: a pilot study. J Am
Diet Assoc 1996;96:1254-61.
Braaten JT, Scott FW, Wood PJ, et al. High beta-glucan oat bran
and oat gum reduce postprandial blood glucose and insulin in
subjects with and without type 2 diabetes. Diabet Med 1994;11:3128.
Chandalia M, Garg A, Lutjohann D, et al. Beneficial effects of high
dietary fiber intake in patients with type 2 diabetes mellitus. N Engl
J Med 2000;342:1392-8.
Diabete – Ginseng
•
Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in noninsulin-dependent diabetic patients. Diabetes Care 1995;18:13731375..
Diabete – Psillio bianco - 1
•
Anderson JW, Allgood LD, Turner J, Oeltgen PR, Daggy BP.
Effects of psyllium on glucose and serum lipid responses in men
with type 2 diabetes and hypercholesterolemia. Am J Clin Nutr.
1999 Oct; 70(4):466-73.
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Pastors JG, Blaisdell PW, Balm TK, Asplin CM, Pohl SL Psyllium
fiber reduces rise in postprandial glucose and insulin concentrations
in patients with non-insulin-dependent diabetes. Am J Clin Nutr.
1991 Jun; 53(6):1431-5.
•
Wolever TM, Vuksan V, Eshuis H, Spadafora P, Peterson RD,
Chao ES, Storey ML, Jenkins DJ. Effect of method of administration
of psyllium on glycemic response and carbohydrate digestibility. J
Am Coll Nutr. 1991 Aug; 10(4):364-71.
•
Frati Munari AC, Benitez Pinto W, Raul Ariza Andraca C,
Casarrubias M. Lowering glycemic index of food by acarbose and
Plantago psyllium mucilage. Arch Med Res. 1998 Summer;
29(2):137-41.
•
Rodriguez-Moran M, Guerrero-Romero F, Lazcano-Burciaga G.
Lipid- and glucose-lowering efficacy of Plantago Psyllium in type II
diabetes. J Diabetes Complications. 1998 Sep-Oct; 12(5):273-8.
•
Sierra M, Garcia JJ, Fernandez N, Diez MJ, Calle AP. Therapeutic
effects of psyllium in type 2 diabetic patients. Eur J Clin Nutr. 2002
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•
Anderson JW, Allgood LD, Turner J, Oeltgen PR, Daggy BP. Effects
of psyllium on glucose and serum lipid responses in men with type 2
diabetes and hypercholesterolemia. Am J Clin Nutr. 1999 Oct;
70(4):466-73.
•
Pastors JG, Blaisdell PW, Balm TK, Asplin CM, Pohl SL. Psyllium
fiber reduces rise in postprandial glucose and insulin concentrations
in patients with non-insulin-dependent diabetes. Am J Clin Nutr. 1991
Jun; 53(6):1431-5.
• Uribe M, Dibildox M, Malpica S, Guillermo E, Villallobos A, Nieto L,
Vargas F, Garcia Ramos G. Beneficial effect of vegetable protein
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88(4):901-7.
•
Wolever TM, Vuksan V, Eshuis H, Spadafora P, Peterson RD,
Chao ES, Storey ML, Jenkins DJ. Effect of method of administration
of psyllium on glycemic response and carbohydrate digestibility. J
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•
Frati Munari AC, Benitez Pinto W, Raul Ariza Andraca C,
Casarrubias M. Lowering glycemic index of food by acarbose and
Plantago psyllium mucilage. Arch Med Res. 1998 Summer;
29(2):137-41.
Diarrea
1
Aglio
TrM
Allium sativum
Amamelide
TrM
Astragalo
TrM
Borsa pastore
TrM
Boswellia
TrM
Boswellia serrata
Meliloto
TrM
Mirtillo, Foglie
TrM
Vaccinium myrtillus
Mirtillo, Frutti
TrM
Vaccinium myrtillus
Ortica, Foglie
TrM
Urtica dioica
Piantaggine
TrM
Plantago lanceolata, Plantago
major
Psillio bianco e nero ClR
ispaghula + Plantago afra,
Plantago indica
Rabarbaro, a basso
dosaggio
TrM
Rheum palmatum
Tribolo
TrM
Tribulus terrestris
Zenzero
TrM
Diarrea – Psillio bianco e nero
•
Washington N, Harris M, Mussellwhite A, Spiller RC. Moderation of lactuloseinduced diarrhea by psyllium: effects on motility and fermentation. Am J Clin
Nutr. 1998 Feb; 67(2):317-21.
•
Eherer AJ, Santa Ana CA, Porter J, Fordtran JS. Effect of psyllium, calcium
polycarbophil, and wheat bran on secretory diarrhea induced by
phenolphthalein. Gastroenterology. 1993 Apr; 104(4):1007-12.
•
Bliss DZ, Jung HJ, Savik K, Lowry A, LeMoine M, Jensen L, Werner C, Schaffer
K. Supplementation with dietary fiber improves fecal incontinence. Nurs Res.
2001 Jul-Aug; 50(4):203-13.
•
Marlett JA, Kajs TM, Fischer MH. An unfermented gel component of psyllium
seed husk promotes laxation as a lubricant in humans. Am J Clin Nutr. 2000
Sep; 72(3):784-9.
•
Qvitzau S, Matzen P, Madsen P. Treatment of chronic diarrhoea: loperamide
versus ispaghula husk and calcium. Scand J Gastroenterol. 1988 Dec;
23(10):1237-40.
•
Strommen GL et al. Treatment of suspected postcholecystectomy diarrea with
psyllium hydrophilici mucilloid. Clin Pharm 1990;9:206-8.
•
Harmouz W. Therapy of acute and chronic diarrhea with Agiocur ®. Medizinische
Klinik, 1984, 79:32-33.
Dismenorrea
3
Achillea
TrM
Agnocasto
TrM
Vitex agnus-castus
Amamelide
TrM
Angelica arcangelica
TrM
Angelica cinese
ClR
Calendula
TrM
Camomilla
TrM
Cimicifuga
ClR
Meliloto
TrM
Mirtillo, Frutti
ClR
Vaccinium myrtillus
Salvia
TrM
Salvia officinalis
Timo
TrM
Thymus vulgaris
TrM
TrM
Angelica sinensis
Cimicifuga racemosa
Dismenorrea – Angelica cinese
•
Compendium of materia medica. Shanghai, State Administration of
Traditional Chinese Medicine, Shanghai Science and Technical
Press, 1996:1341-1355
Dismenorrea – Cimicifuga
•
Görlich N. Behandlung ovarieller Störungen in der Allgemeinpraxis.
Ärztliche Praxis, 1962, 14:1742–1743.
•
Stiehler K. Über die Anwendung eines standardisierten CimicifugaAuszuges in der Gynäkologie. Ärztliche Praxis, 1959, 26:916–917.
Emorroidi
Emorroidi, Uso
esterno
3
3
Achillea
TrM
Amamelide
TrM
Cardo
mariano
TrM
Carduus marianus
Ippocastano
TrM
Aesculus ippocastanus
Meliloto
TrM
Mirtillo, Frutti
ClR
TrM
Vaccinium myrtillus
Psillio bianco ClR
TrM
ispaghula
Pungitopo
TrM
Ruscus aculeatus
Achillea
TrM
Amamelide
ClR
Fieno Greco
TrM
Iperico
TrM
Hypericum perforatum
Ippocastano
TrM
Pungitopo
TrM
Ruscus aculeatus
TrM
Emorroidi – Mirtillo frutti
•
Teglio et al 1987, citato da Upton R et al., eds. Bilberry fruit. Vaccinium
myrtillus L. In: American Herbal Pharmacopoeia. Santa Cruz, CA,
American Herbal Pharmacopoeia, 2001.
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Pezzangora et al 1984, citato da Upton R et al., eds. Bilberry fruit.
Vaccinium myrtillus L. In: American Herbal Pharmacopoeia. Santa
Cruz, CA, American Herbal Pharmacopoeia, 2001.
.
Emorroidi – Psillio bianco
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Ho YH, Tan M, Seow-Choen F. Micronized purified flavonidic fraction
compared favorably with rubber band ligation and fiber alone in the
management of bleeding hemorrhoids: randomized controlled trial.
Dis Colon Rectum. 2000 Jan; 43(1):66-9.
Emorroidi – Amamelide
•
•
Knoch HG. Hämorrhoiden ersten Grades: Wirksamkeit einer Salbe
auf pflanzlicher Basis. Münchener Medizinische Wochenschrift, 1991,
133:481–484.
Reynolds JEF, Prasad AB. Martindale, the extra pharmacopoeia,
30th ed. London, The Pharmaceutical Press, 1996.
Epatiti, come
coadiuvante, ed
epatopatie
2
Achillea
ClR
TrM
Angelica arcangelica
TrM
Astragalo
ClR
TrM
Bardana
PhR
TrM
Arctium lappa
Calendula
TrM
Cardo mariano
ClR1
ClR2
ClR3
ClR4
Cordyceps
TrM
Cordyceps sinensis
Curcuma
TrM
Curcuma longa
Desmodium
TrM
Desmodium adscendens
Elicriso
TrM
Fieno Greco
TrM
Fumaria
TrM
Fumaria officinalis
Ganoderma
TrM
Ganoderma lucidum
Ginseng
TrM
Panax ginseng
Iperico
TrM
Hypericum perforatum
Ippocastano
TrM
Liquirizia
TrM
Glycyrrhiza glabra
Schisandra
PhR1
PhR2
TrM
TrM
Carduus marianus
Schisandra sinensis
Epatiti ed epatopatie – Achillea
•
Harnic TP. The use of preparations of plant origin in treating and
rehabilitating elderly patients with cronic hepatitis. Lik Sprava 1999, (78): 168-170.
•
Sama SK, Krishnamurthy L, Ramachandran K, Lal K. Efficacy of an
indigenous compound preparation (Liv-52) in acute viral hepatits: A
double-blind study. Indian J Med Res 64:738-742, 1976.
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Epatiti ed epatopatie – Astragalo
•
Zhou QJ. Chinese medicinal herbs in the treatment of viral hepatitis.
World Scientific, 215-219, Singapore, 1985.
•
Kitagawa I, Wang HK, Takagi A, Fuchida M, Miura I, Saito M,
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Epatiti ed epatopatie – Cardo mariano - 1
•
•
•
•
•
Albrecht M et al. Die Therapie toxischer Leberschäden mit Legalon®.
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hausärztlichen Praxis. Die Medizinische Welt, 1995, 46:222–227.
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Müzes M et al. Silymarin (Legalon®) kezelés hatása idült alkoholos
májbetegek antioxidáns védorendszerée és a lipid peroxidációra
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Láng I et al. Hepatoprotective and immunomodulatory effects of
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•
Feher J et al. Hepatoprotective activity of silymarin Legalon therapy in
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•
Ferenci P et al. Randomized controlled trial of silymarin treatment in
patients with cirrhosis of the liver. Journal of Hepatology, 1989, 9:105–
113.
•
Magliulo E, Gagliardi B, Fiori GP: Results of a double-blind study on
the effect of silymarin in the treatmen of acute viral hepatitis, carried out
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•
Buzzelli G, Moscarella S, Giusti A, et al: A pilot study on the liver protective
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•
Kiesewetter E, Leodolter I, Thaler H: Results of two double-blind studies
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•
Szilárd S et al. Protective effect of Legalon® in workers exposed to organic
solvents. Acta Medica Hungarica, 1988, 45:249–256.
•
Magula D, Galisova Z, Iliev N, et al: Effect of silymarine and Fumaria
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•
•
•
Palasciano G et al. The effect of silymarin on plasma levels of
malondialdehyde in patients receiving long-term treatment with
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Saba P et al. Effetti terapeutici della silimarina nelle epatopatie
croniche indotte da psicofarmaci. Gazzetta Medicina ITALIANA, 1976,
135:236-251.
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prognostic factors and therapeutic measures. Analys of 205 cases.
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Epatiti ed epatopatie – Schisandra - 1
•
Chiu PY, Mak DH, Poon MK, Ko KM. In vivo antioxidant action of a
lignan-enriched extract of Schisandra fruit and an anthraquinonecontaining extract of Polygonum root in comparison with schisandrin B
and emodin. Planta Med. 2002 Nov;68(11):951-6.
• Zhu M, Yeung RY, Lin KF, Li RC Improvement of phase I drug
metabolism with Schisandra chinensis against CCl4 hepatotoxicity in
a rat model Planta Med. 2000 Aug;66(6):521-5.
• Ip SP, Yiu HY, Ko KM. Schisandrin B protects against menadioneinduced hepatotoxicity by enhancing DT-diaphorase activity. Mol Cell
Biochem. 2000 May;208(1-2):151-5.
• Ip SP, Yiu HY, Ko KM. Differential effect of schisandrin B and dimethyl
diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione
redox status in carbon tetrachloride intoxicated mice. Mol Cell
Biochem. 2000 Feb;205(1-2):111-4
Epatiti ed epatopatie – Schisandra - 2
•
Zhu M, Lin KF, Yeung RY, Li RC. Evaluation of the protective effects
of Schisandra chinensis on Phase I drug metabolism using a CCl4
intoxication model J Ethnopharmacol. 1999 Oct;67(1):61-8.
•
Ip SP, Mak DH, Li PC, Poon MK, Ko KM Effect of a lignan-enriched
extract of Schisandra chinensis on aflatoxin B1 and cadmium
chloride-induced hepatotoxicity in rats. Pharmacol Toxicol. 1996
Jun;78(6):413-6.
Febbre 3 Achillea
PhR
TrM Achillea
millefolium
Artiglio del
diavolo
TrM
Harpagophytum
procumbens
Bardana
TrM
Arctium lappa
Genziana
TrM
Gentiana Lutea
Ginseng
TrM
Panax ginseng
Salice
PhR
Sambuco
TrM
Sambucus nigra
Zenzero
TrM
TrM Salix alba
Febbre – Achillea
•
Nikonorow M. Investigation of the antipyretic action of native
medicinal plants. Acta Poloniae Pharmaceutica, 1939, 3:23-56.
Febbre – Salice
• Leslie GB. A pharmacometric evaluation of nine bio-strath herbal
remedies. Medita, 1978, 8:3-19.
•
Fiebich BL, Appel K. Anti-inflammatory effects of willow bark extract.
Clinical Pharmacology & Therapeutics, 2003, 74:96-97.
Ferite e
piaghe
1
Ferite
infette
1
Ferite
1
Boswellia
TrM
Centella
ClR
Meliloto
TrM
Piantaggine
TrM
Echinacea a.
PhR
TrM
Echinacea p.
ClR
TrM
Echinacea purpurea
Achillea
ClR
TrM
Aloe
ClR
TrM
Aloe vera
Amamelide
TrM
Bardana
PhR
Arctium lappa
Borsa pastore
TrM
Ficodindia
TrM
Piantaggine
TrM
Primula, Rizoma
TrM
Primula veris
Timo
TrM
Thymus vulgaris
Uncaria
TrM
Uncaria procumbens
Boswellia serrata
TrM
Centella asiatica
Ferite e piaghe – Centella
•
•
•
•
•
•
•
•
•
Morisset R et al. Evaluation of the healing activity of Hydrocotyle tincture
in the treatment of wounds. Phytotherapy research, 1987, 1:117.
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cicatrization of leg ulcers (10 mg tablets). Apropos of 50 cases. Lille
medicale, 1972, 17(Suppl. 3):574–579.
Bourde C, Bourde J. The place of cicatrizing agents in leg ulcers.
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Nebout M. Résultats d’un essai controlé de l’extrait titré de Centella
asiatica (E.T.C.A.) (I) dans une population lepreuse présentant des maux
perforants plantaires. Bulletin de la Société de Pathologie exotique,
1974, 67:471–478.
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Ferite infette – Echinacea angustifolia
• Rehman J, Dillow JM, Carter SM, Chou J, Le B, Maisel AS. Increased
production of antigen-specific immunoglobulins G and M following in
vivo treatment with the medicinal plants Echinacea angustifolia and
Hydrastis canadensis. Immunol Lett. 1999 Jun 1;68(2-3):391.
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• Schwarz E, Metzler J, Diedrich JP, et al. Oral administration of freshly
expressed juice of Echinacea purpurea herbs fail to stimulate the
nonspecific immune response in healthy young men: results of a
double-blind, placebo-controlled crossover study. J Immunother
2002;25:413-20.
Ferite infette – Echinacea purpurea
• Schwarz E, Metzler J, Diedrich JP, et al. Oral administration of freshly
expressed juice of Echinacea purpurea herbs fail to stimulate the
nonspecific immune response in healthy young men: results of a
double-blind, placebo-controlled crossover study. J Immunother
2002;25:413-20.
Ferite – Aloe
•
•
•
•
Reynolds T, Dweck AC: Aloe vera leaf gel: A review update. J
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Boon H, Smith M: The Botanical Pharmacy: The Pharmacology of 47
Common Herbs. Kingston, Ontario, Quarry Press, 1999.
Klein AD, Penneys NS. Aloe vera. J Am Acad Dermatol 1988;18:71420.
Chithra P, Sajithlal GB, Chandrakasan G Influence of aloe vera on
the healing of dermal wounds in diabetic rats. J Ethnopharmacol 1998
Jan;59(3):195-201.
Gastrite e
ulcera
gastrica
2 Achillea
ClR
TrM
Aloe
TrM
Aloe vera
Altea
TrM
Althea officinalis
Calendula
TrM
Eleuterocco
TrM
Eleutherococcus senticosus
Ficodindia
TrM
Ginseng
TrM
Panax ginseng
Liquirizia
PhR1
PhR2
ClR
Ortica,
Foglie
TrM
Urtica dioica
Piantaggine
TrM
Psillio bianco
e nero
TrM
Plantago ovata, Plantago ispaghula
e Plantago afra, Plantago indica
Uncaria
TrM
Uncaria procumbens
Withania
TrM
Withania somnifera
Zenzero
TrM
TrM
Glycyrrhiza glabra
Gastropatie – Achillea
•
Mahler P. The action of bitters on the secretion of gastric juice.
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Ulcera gastrica – Liquirizia 1
•
•
•
•
•
•
•
Jones FA, Langman MJS, Mann RO (eds). Peptic ulcer healing:
recent studies on carbenoxolone. MTP Press, Lancaster, 1978, p 1.
Lojda Z, Maratka Z. Histochemistry of the gastric and duodenal
mucosa under cimetidine and carbenoxolone treatment. Scand J
Gastroenterol Suppl. 1989;167:13-5.
McLean AJ, Harcourt DM, McCarthy PG, Dudley FJ, McNeil JJ.
Relative effectiveness and costs of antiulcer medications as a basis
for rational prescribing. Med J Aust. 1987 Apr 20;146(8):431-3, 4368, 442.
van Marle J, Aarsen PN, Lind A, van Weeren-Kramer J.
Deglycyrrhizinised liquorice (DGL) and the renewal of rat stomach
epithelium. Eur J Pharmacol 1981; 72:219-25.
Turpie AG, Runcie J, Thomson TJ. Clinical trial of deglycyrrhizinized
liquorice in gastric ulcer. Gut 1969; 10:299-302.
Tewari SN, Wilson AK. Deglycyrrhizinated liquorice in duodenal
ulcer. Practitioner 1973; 210:820-3.
Balker ME, Fanestil DD. Liquorice as a regulator of steroid and
prostaglandin metabolism. Lancet 1991; 337:428-429.
Ulcera gastrica – Liquirizia 2
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Dehpour AR et al. The protective effect of liquorice components and
their derivatives against gastric ulcer induced by aspirin in rats.
Journal of pharmacy and pharmacology, 1994, 46:148–149.
•
Russell RI, Morgan RJ, Nelson LM. Studies on the protective effect
of deglycyrrhinized liquorice against aspirin (ASA) and ASA plus bile
acid-induced gastric mucosal damage, and ASA absorption in rats.
Scandinavian journal of gastroenterology, 1984, 19(Suppl.):97–100.
.
Ulcera gastrica – Liquirizia
•
Morgan AG, Pacsoo C, McAdam WAF. Comparison between
ranitidine and ranitidine plus Caved-S in the treatment of gastric
ulceration. Gut 1985; 26:1377-1379.
•
Schenk J, Schmack B, Rosch W, Domschke W. Controlled trial of
carbenoxolone sodium vs. cimetidine in duodenal ulcer. Scand J
Gastroenterol Suppl 1980;65:103-107.
•
Young GP, Nagy GS, Myren J, et al. Treatment of reflux esophagitis
with a carbenoxolone/antiacid/alginate preparation. A double-blind
controlled trial. Scand J Gastroenterol 1986; 21: 1 098-11 04.
Immunodeficienza
3
Aloe
TrM
Astragalo
PhR
ClR
TrM
Cordyceps
PhR
ClR
TrM
Cordyceps sinensis
Echinacea a.
PhR
TrM
Echinacea p.
PhR
TrM
Echinacea purpurea
Eleuterocco
PhR
TrM
Ganoderma
PhR
Ganoderma lucidum
Liquirizia
TrM
Glycyrrhiza glabra
Schisandra
ClR
Schisandra sinensis
Uncaria
PhR
Uncaria procumbens
Aloe vera
Immunodeficienza – Astragalo
•
•
Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese
medicinal herbs I. Immune restoration of local xenogeneic graft-versushost reactions in cancer patients by fractionated Astragalus
membranaceus in vitro. ]ournal of clinical laboratory immunology,
1988, 25:119-123.
•
Chu DT, Wong WI, Mavligit GM. Immunotherapy with Chinese
medicinal herbs II. Reversal of cyclophosphamide-induced immune
suppression by administration of fractionated Astragalus
membranaceus in vivo. Journal of clinical laboratory immunology,
1988,25:125-129.
•
Zhou KS, Mancini C, Doria G. Enhancement of the immune response
in mice by Astragalus membranaceus extracts. Immunopharmacology,
1990, 20:225-233.
•
Chu DT et al. Fractionated extract of Astragalus membranaceus, a
Chinese medicinal herb, potentiates LAK cell cytotoxicity generated by
a low dose of recombinant interleukin-2. Journal of clinical laboratory
immunology, 1988, 26:183-187.
Immunodeficienza – Cordiceps
•
•
•
•
•
Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on
murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
Xu RH, Peng XE, Chen GZ, Chen GL. Effects of cordyceps sinensis on
natural killer activity and colony formation of B16 melanoma. Chin Med
J (English) 1992;105:97-101.
Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis
on the proliferation and differentiation of human leukemic U937 cells.
Life Sci 1997;60:2349-59.
Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on
murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious
ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern
Complement Med 1998;4:429-57
Immunodeficienza – Echinacea angustifolia
•
Bauer R et al. Immunological in vivo examinations of Echinacea
extracts. Arzneimittel-Forschung, 1988, 38:276–281.
•
Goel V, Chang C, Slama J, Barton R, Bauer R, Gahler R. Echinacea
stimulates macrophage function in the lung and spleen of normal rats.
J Nutr Biochem. 2002 Aug;13(8):487.
•
Rehman J, Dillow JM, Carter SM, Chou J, Le B, Maisel AS. Increased
production of antigen-specific immunoglobulins G and M following in
vivo treatment with the medicinal plants Echinacea angustifolia and
Hydrastis canadensis. Immunol Lett. 1999 Jun 1;68(2-3):391.
.
Immunodeficienza – Echinacea purpurea
•
•
•
•
•
•
.
Luettig B, Steinmuller C, Gifford GE, et al. Macrophage activation by
the polysaccharide arabinogalactan isolated from plant cell cultures of
Echinacea purpurea. J Natl Cancer Inst 1989;81:669-75.
Stimpel M, Proksch A, Wagner H, et al. Macrophage activation and
induction of macrophage cytotoxicity by purified polysaccharide
fractions from the plant Echinacea purpurea. Infect Immun
1984;46:845-9.
Bauer R et al. Immunological in vivo examinations of Echinacea
extracts. Arzneimittel-Forschung, 1988, 38:276–281.
Goel V, Chang C, Slama J, Barton R, Bauer R, Gahler R. Echinacea
stimulates macrophage function in the lung and spleen of normal rats.
J Nutr Biochem. 2002 Aug;13(8):487.
Stotzem CD, Hungerland U, Mengs U. Influence of Echinacea
purpurea on the phagocytosis of human granulocytes. Medical science
research, 1992, 20:719–720.
Bodinet C, Lindequist U, Teuscher E, Freudenstein J. Effect of an
orally applied herbal immunomodulator on cytokine induction and
antibody response in normal and immunosuppressed mice.
Phytomedicine. 2002 Oct;9(7):606-13.Related Articles, Links
Immunodeficienza – Eleuterococco
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Szolomicki S, Samochowiec L, Wojcicki J, Drozdzik M. The influence
of active components of Eleutherococcus senticosus on cellular
defense and physical fitness in man. Phytother Res 2000;14:30-5.
Immunodeficienza – Ganoderma
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Wasser SP, Weis AL. Therapeutic effects of substances occurring in
higher Basidiomycetes mushrooms: a modern perspective. Crit Rev
Immunol. 1999;19(1):65-96.
•
Wasser SP Medicinal mushrooms as a source of antitumor and
immunomodulating polysaccharides. Appl Microbiol Biotechnol. 2002
Nov;60(3):258-74.
•
Wang SY, Hsu ML, Hsu HC, et al. The anti-tumor effect of Ganoderma
lucidum is mediated by cytokines released from activated
macrophages and T lymphocytes. Int J Cancer 1997;70:699-705.
•
Yuen JW, Gohel MD. Anticancer effects of Ganoderma lucidum: a
review of scientific evidence. Nutr Cancer 2005;53:11-7.
Kim HS, Kacew S, Lee BM. In vitro chemopreventive effects of plant
polysaccharides (Aloe barbadensis miller, Lentinus edodes,
Ganoderma lucidum and Coriolus versicolor). Carcinogenesis
1999;20:1637-40
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Immunodeficienza – Schisandra
•
Kormosh N, Laktionov K, Antoshechkina M. Effect of a combination of
extract from several plants on cell-mediated and humoral immunity of
patients with advanced ovarian cancer. Phytother Res. 2006
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Immunodeficienza – Uncaria
•
•
•
•
•
•
•
•
Lin et al Lin CC, Lin JM, Chili HF. Studies on folk medicine "thang-kau-tin"
from Taiwan (I), the antiinflammatory and liver-protectant effect. Chung-kuo
chung yao tsa chi li, 1990, 15:617-622.
Kiuchi F et al. Inhibition of prostaglandin biosynthesis by the constituents of
medicinal plants. Chemical and pharmaceutical bulletin, 1983, 31:3391-3396.
Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: Role in cytoprotection. Free
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Lemaire I, Assinewe V, Cano P, et al. Stimulation of interleukìn-1 and -6
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Insonnia
2
Biancospino
PhR
TrM
Cimicifuga
TrM
Cimicifuga racemosa
Eleuterocco
TrM
Ganoderma
TrM
Ganoderma lucidum
Luppolo
PhR
ClR
Meliloto
TrM
Melissa
ClR
TrM
Melissa officinalis
Passiflora
PhR
TrM
Passiflora incarnata
Primula, Fiori
TrM
Primula veris
Salice
TrM
Salix alba
Valeriana
PhR
ClR
TrM
Withania
PhR
TrM
Withania somnifera
TrM
Humulus lupulus
Insonnia – Biancospino
•
Beretz A et al. Choix de méthodes pharmacologiques pour l’étude des
activités de l’aubépine. Plantes médicinales et Phytothérapie, 1978,
12:305-314.
•
Della Loggia R et al. Depressive effect of Crataegus oxyacantha L. on
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Insonnia – Luppolo
•
•
•
Schmitz, M. and M. Jackel. 1998. Comparative study for assessing
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Insonnia – Melissa
•
Cerny A, Schmid K: Tolerability and efficacy of valerian/lemon balm in
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•
Dressing H, Riemann D, Low H, et al: Insomnia: Are valerian/balm
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Insonnia – Passiflora
•
Speroni E, Billi R, Mercati V, et al: Sedative effects of crude extract of
Passiflora incarnata after oral administration. Phytotherapy Res
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Insonnia – Valeriana
•
•
•
•
•
•
Yuan CS, Mehendale S, Xiao Y, et al. The gamma-aminobutyric
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Insonnia – Withania
•
Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic
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Iperlipemia
2
Aglio
PhR
ClR
TrM
Aloe
ClR
Carciofo
ClR
Curcuma
ClR
Ficodindia
PhR
TrM
Fieno
Greco
ClR
TrM
Psillio
bianco
ClR1
ClR2
Allium sativum
Aloe vera
TrM
Cynara scolymus
Curcuma longa
ispaghula
Iperlipemia – Aglio
•
•
•
•
•
•
•
Lawson LD et al. HPLC analysis of allicin and other thiosulfinates in
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Iperlipemia – Aglio
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Silagy CA, Neil A. Garlic as a lipid lowering agent: a meta-analysis.
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•
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•
Auer, W. et al. 1.990. Hypertension and hyperlipidaemia: garlic helps in
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Iperlipemia – Aloe
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Iperlipemia – Carciofo
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Lietti A. Choleretic and cholesterol lowering properties of two artichoke
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Montini M et al. Controlled application of cynarin in the treatment of
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•
Petrowicz o et al.. Effects of artichoke leaf extract (ALE) on lipoprotein
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Iperlipemia – Curcuma
•
Soni KB, Kuttan R. Effect of oral curcumin administration on serum
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•
Chang H-M, But PP-H, Pharmacology and Applications of Chinese
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Iperlipemia – Ficodindia
•
Fernandez ML, Lin EC, Trejo A, McNamara DJ. Prickly pear (Opuntia
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Iperlipemia – Fienogreco
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Kuppurajan K, Srivatsa A,. Krishnaswami CV, et al. Hypoglycemic and
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•
Sowmya A, Rajyalakshmi P. Hypocholesterolemic effect of germinated
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Iperlipemia – Psillio bianco 1
•
•
•
•
•
Anderson JW, Allgood LD, Lawrence A, Altringer LA, Jerdack GR,
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Iperlipemia – Psillio bianco 2
•
•
•
•
•
•
Roberts DC, Truswell AS, Bencke A, Dewar HM, Farmakalidis E. The
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Ipertensione di
grado lieve
Ipertensione,
come
coadiuvante
1
1
Aglio
PhR
ClR
TrM
Allium sativum
Biancospino
PhR
ClR
TrM
Achillea
TrM
Angelica
cinese
TrM
Angelica sinensis
Astragalo
PhR
Chelidonia
TrM
Chelidonium majus
Ganoderma
TrM
Ganoderma lucidum
Ginseng
TrM
Panax ginseng
Tribolo
PhR
Valeriana
TrM
Vischio
TrM
Viscum album
TrM
Tribulus terrestris
Ipertensione – Aglio
•
Petkov V. Pharmacological and clinical studies of garlic. Deutsche
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•
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Das I, Khan NS, Sooranna SR. Potent activation of nitric oxide
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Ipertensione – Aglio
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Neil HA, Silagy CA. Garlic: its cardioprotectant properties. Current
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Ipertensione – Biancospino
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Menopausa
2
Agnocasto
ClR
Vitex agnus-castus
Angelica
cinese
TrM
Angelica sinensis
Cimicifuga
PhR
ClR
Luppolo
ClR
Humulus lupulus
Meliloto
TrM
Salvia
TrM
Salvia officinalis
Withania
TrM
Withania somnifera
TrM
Cimicifuga racemosa
Menopausa – Agnocasto
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•
•
•
•
•
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•
•
•
•
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Stipsi
3
Aloe
TrM
Aloe vera
solo
Altea
TrM
Althea officinalis
ClR
Angelica cinese
TrM
Angelica sinensis
Carciofo
PhR
Ficodindia
TrM
Psillio nero
ClR
TrM
Plantago afra, Plantago indica
Rabarbaro
ClR
TrM
Rheum palmatum
Sambuco, Frutti
TrM
TrM
Cynara scolymus
Sambucus nigra
Stipsi – Psillio nero
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•
•
•
•
•
•
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Stipsi – Rabarbaro
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Stress
3
Centella
TrM
Centella asiatica
sol
o
Eleuterocco
TrM
Cl
R
Ganoderma
TrM
Ganoderma lucidum
Ginseng
ClR
TrM
Panax ginseng
Rodiola
ClR
TrM
Rhodiola rosea
Schisandra
TrM
Schisandra sinensis
Tribolo
TrM
Tribulus terrestris
Valeriana
TrM
Withania
ClR
TrM
Withania somnifera
Stress – Ginseng
•
•
•
•
•
•
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come
coadiuvante
2
Aloe
TrM
sol
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Astragalo
ClR
ClR
Avena
ClR
Avena sativa
Boswellia
TrM
Boswellia serrata
Chelidonia
TrM
Chelidonium majus
Curcuma
TrM
Curcuma longa
Echinacea a.
TrM
Ganoderma
ClR
Ginseng
ClR
Panax ginseng
Meliloto
ClR
Uncaria,
PhR
TrM
Uncaria procumbens
Vischio
PhR
TrM
Viscum album
Aloe vera
TrM
TrM
Ganoderma lucidum
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•
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•
Thornes RD, Daly L, Lynch G, Breslin B, Browne H, Browne HY, Corrigan
T, Daly P, Edwards G, Gaffney E, et al. Treatment with coumarin to
prevent or delay recurrence of malignant melanoma. J Cancer Res Clin
Oncol. 1994;120 Suppl:S32-4.
•
Mohler JL, Williams BT, Thompson IM, Marshall ME. Coumarin (1,2benzopyrone) for the treatment of prostatic carcinoma. J Cancer Res Clin
Oncol. 1994;120 Suppl:S35-8.
•
Marshall ME, Mendelsohn L, Butler K, Riley L, Cantrell J, Wiseman C,
Taylor R, Macdonald JS. Treatment of metastatic renal cell carcinoma
with coumarin (1,2-benzopyrone) and cimetidine: a pilot study. J Clin
Oncol. 1987 Jun;5(6):862-6.
Evidenze cliniche in agopuntura
secondo l’OMS
Selection of clinical trial reports

randomized controlled trials (mostly
with sham acupuncture or
conventional therapy as control) with
an adequate number of patients
observed;
nonrandomized controlled clinical
trials (mostly group comparisons)
with an adequate number of patients
observed and comparable conditions
in the various groups prior to
treatment.
1. Diseases, symptoms or conditions for which acupuncture has been
proved—through controlled trials—to be an effective treatment:
Adverse reactions to radiotherapy and / or
chemotherapy
•
Leukopenia
•
Low back pain
•
Allergic rhinitis (including hay fever)
•
Malposition of fetus, correction of
•
Biliary colic
•
Morning sickness
•
Depression (including depressive neurosis
and depression following stroke)
•
Nausea and vomiting
•
Dysentery, acute bacillary
•
Neck pain
•
Dysmenorrhoea, primary
•
Pain in dentistry (including dental pain and
temporomandibular dysfunction)
•
Epigastralgia, acute (in peptic ulcer, acute
and chronic gastritis, and gastrospasm)
•
Periarthritis of shoulder
•
Facial pain (including craniomandibular
disorders)
•
Postoperative pain
•
Renal colic
•
•
Headache
•
Rheumatoid arthritis
•
Hypertension, essential
•
Sciatica
•
Hypotension, primary
•
Sprain
•
Induction of labour
•
Stroke
•
Knee pain
•
Tennis elbow
2. Diseases, symptoms or conditions for which the therapeutic effect of
acupuncture has been shown but for which further proof is needed:
•
Abdominal pain (in acute gastroenteritis or
due to gastrointestinal spasm)
•
Acne vulgaris
•
Alcohol dependence and detoxification
•
Bell's palsy
•
Bronchial asthma
•
Cancer pain
•
Cardiac neurosis
•
Cholecystitis,
exacerbation
•
Cholelithiasis
•
Competition stress syndrome
•
Craniocerebral injury, closed
•
Diabetes mellitus, non-insu1in-dependent
•
Earache
•
Epidemic haemorrhagic fever
•
Epistaxis, simple (without genera1ized or
local disease)
chronic,
with
acute
•
Eye pain due to subconjunctival injection
•
Female inferti1ity
•
Facial spasm
•
Female urethral syndrome
•
Fibromyalgia and fasciitis
•
Gastrokinetic disturbance
•
Gouty arthritis
•
Hepatitis B virus carrier status
•
Herpes zoster (human (alpha) herpesvirus
3)
•
Hyperlipaemia
•
Hypo-ovarianism
•
Insomnia
•
Labour pain
•
Lactation, deficiency
•
Male sexual dysfunction, non-organic
•
Menière disease
•
Neuralgia, post-herpetic
2. Diseases, symptoms or conditions for which the therapeutic effect of
acupuncture has been shown but for which further proof is needed:
•
Neurodermatitis
•
Obesity
•
Retention of urine, traumatic
•
Opium, cocaine and heroin dependence
•
Schizophrenia
•
Osteoarthritis
•
Sialism, drug-induced
•
Pain due to endoscopic examination
•
Sjogren syndrome
•
Pain in thromboangiitis obliterans
•
Sore throat (including tonsillitis)
•
Polycystic ovary syndrome (Stein-Leventhal
syndrome)
•
Spine pain, acute
•
Stiff neck
•
Temporomandibular joint dysfunction
•
Tietze syndrome
•
Tobacco dependence
•
Tourette syndrome
•
Ulcerative colitis, chronic
•
Urolithiasis
•
Vascular dementia
•
Whooping cough (pertussis)
•
Postextubation in children
•
Postoperative convalescence
•
Premenstrual syndrome
•
Prostatitis, chronic
•
Pruritus
•
Radicular
syndrome
•
Raynaud syndrome, primary
•
Recurrent lower urinary-tract infection
•
Reflex sympathetic dystrophy
and
pseudoradicular
pain
3. Diseases, symptoms or conditions for which there are only individual
controlled trials reporting some therapeutic effects, but for which
acupuncture is worth trying because treatment by conventional and
other therapies is difficult:
•
Chloasma
•
Insufficienza vascolare venosa**
•
Choroidopathy, central serous
•
Parodontopatia**
•
Clour dness
•
Sindrome del Tunnel Carpale**
•
Irritable colon syndrome
•
Neuropathic bladder in spinal
cord injury
•
Small airway obstruction
4. Diseases, symptoms or conditions for which acupuncture may be tried
provided the practitioner has special modern medical knowledge and
adequate monitoring equipment:
•
Breathlessness
in
chronic
obstructive pulmonary disease
•
Coma
•
Convulsions in infants
•
Coronary heart disease ( angina
pectoris )
•
Diarrhoea in infants and young
children
•
Encephalitis, viral, in children, late
stage
•
Paralysis, progressive bulbar and
pseudobulbar
•
Linfedema post-mastectomia**
Homeopathy Clinical Studies
Selection of clinical trial reports

Systematic reviews and meta-analyses
of homeopathy in humans
Selected Randomized Controlled
Trials
- selected randomized controlled
trials on high dilutions.
- selected randomized controlled
trials with low dilutions
G
O
V
E
R
N
M
E
N
T
O
F
I
N
D
I
A
Dr.ESWARA DAS. MD(Hom), MBA (Health Care)
Deputy Adviser (Homoeopathy)
Ministry of Health & Family Welfare
Government of India.
G
O
V
E
R
N
M
E
N
T
O
F
I
N
D
I
A
HOMOEOPATHY IN INDIA
Homoeopathy is recognized as one of the
National systems of Medicine.
Government has taken steps on the following four
sectors to develop Homoeopathy

EDUCATION
RESEARCH**
DRUG DEVELOPMENT
HEALTH CARE SERVICES
G
O
V
E
R
N
M
E
N
T
RESEARCH IN HOMOEOPATHTY

Research in Homoeopathy is encouraged
through two routes:
INTRAMURAL ROUTE
O
F
I
N
D
I
A
EXTRAMURAL ROUTE
G
O
V
E
R
N
M
E
N
T
O
F
I
N
D
I
A
CENTRAL COUNCIL FOR
RESEARCH IN HOMOEOPATHY

Carry out:
• Clinical Research
• Drug Research
• Drug Standardization
• Literary Research
• Documentation
• Survey of Medicinal Plants used in
Homoeopathy
MAJOR RESEARCH WORKS
BEING CARRIED OUT
G
O
V
E
R
N
M
E
N
T

O
F

I
N
D
I
A

HIV/AIDs
–
Pilot
study
suggest
Homoeopathic medicines could control
opportunistic infections and improve the
quality of life of the patients.
Homoeopathic medicines have a major
role in drug de-addiction programmes
Proved 36 Indian Drugs and Monographs
published.
G
O
V
E
R
N
M
E
N
T
O
F
EXTRAMURAL ROUTE

I
N
D
I
A
In the Extramural Route, the Government extend
funds
to
other
organizations/
Universities/
Institutions to carry out research in identified areas.
This is to encourage the talents available out side the
Government institution to contribute development of
the system
Research work is awarded to accredited institutions
Financial assistance subject to a maximum of
Rs 25 lakhs is provided to projects.
The projects are assessed by Technical evaluation
Committee by Technical experts and finally approved
by a Screening Committee headed by Secretary
(AYUSH)
G
O
V
E
R
N
M
E
N
T
O
F
RESEARCH COMPLETED/ONGOING

I
N
D
I
A

Homoeopathic Medicines are found to be useful in
detoxifying Chronic Arsenicosis by National
Institute of Homeopathy
Homoeopathic Medicines are found to be effective
in the treatment of Keloid by Aurobindo Ashram
jointly with Jawaharlal Nehru Institute of Post
Graduate Medicinal Education and Research.
Rheumatoid Arthritis at two centers
Obesity at one center
Lead poisoning in one center.
Cancer research at All India Institute of Medical
Sciences
Chelidoniun 30, is found to be effective in
the
management of Liver Toxicity in animal studies.
G
O
V
E
R
N
M
E
N
T
O
F
I
N
D
I
A
EVIDENCE BASED
HOMOEOPATHY -HEALTH CARE

Homoeopathic Medicines are widely used
as an independent or as an adjuvant
treatment in Cancer.
Improve the quality of life of patients
with HIV/AIDs
People uses widely for Skin complaints,
Viral
infections,
various
Iatrogenic
conditions, Allergic diseases, Pediatric
problems and Behavioral disorders.
G
O
V
E
R
N
M
E
N
T
O
F
I
N
D
I
A
PREVENTIVE AND PROMOTIVE HEALTH CARE

Uses in Drug- de- addiction programme by Delhi
police.
Uses in Japanese Encephalitis control programme
by the Government of Andhra Pradesh.
Leptospirosis by the Government of Kerala.
Found to
be effective in Drug resistant
Tuberculosis. – research is going on under the State
Research programme of Govt. of Delhi.
In the Hypothyroidism and Malnutrition syndromes.
Primary Health care through 10,000 Govt. and
thousand of Private and Charitable institutions.
G
O
V
E
R
N
M
E
N
T
O
F
I
N
D
I
A
NEW AREAS OF INTEREST

Use of Homoeopathy in veterinary practice
is increasing.
In
plant
protection
Homoeopathic
medicines are used.
Dental diseases Homoeopathic medicines
are getting more popular.

A double-blind, placebo

Transcription

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