2012 - 2013 Annual Report
Transcription
2012 - 2013 Annual Report
School of Medicine Faculty of Health Sciences 2012 RESEARCH REPORT Regional Clinical Practice Research Centre 2012 Research March 2013 -2- MESSAGE FROM THE DIRECTOR OF THE CENTRE ....................................................................... - 4 CENTRE MEMBERSHIP.............................................................................................................. - 5 PROFESSIONAL, ACADEMIC AND HONORARY STAFF................................................................................... - 5 RESEARCH GRANTS AND CONTRACTS ..................................................................................... - 10 COMPETITIVE FUNDING ...................................................................................................................... - 10 RESEARCH PUBLICATIONS ...................................................................................................... - 12 PEER REVIEWED PUBLICATIONS ........................................................................................................... - 12 APPROVED RESEARCH............................................................................................................ - 20 AWARDS AND PRIZES............................................................................................................. - 45 COMMUNITY AND PROFESSIONAL ACTIVITIES ........................................................................ - 46 MAJOR PARTNERS AND LINKAGES.......................................................................................... - 47 CONTACT DETAILS.................................................................................................................. - 48 - -3- Regional Clinical Practice Research Centre Message from the Director of the Centre 2012 saw the finalisation of plans for the $2.255M HWA funded Nambour Academic and Research Centre (NARC). Upon the completion of the NARC in mid 2013 the Regional Clinical Practice Research Centre will share space with the Sunshine Coast Hospital & Health Service Research Office, the University of the Sunshine Coast and the Sunshine Coast Clinical School. Architects impression – Nambour Academic and Research Centre In 2012 the Research Board and Health Service restructured the Clinical Trials team and processes. Combined with the opening of the NARC, this will enable an increase in clinical trials and conduct of original clinical research studies. The Centre experienced a significant increase in research activity throughout 2012 which is evidenced by the below snapshot. Activity Approved Grants Approved Research Publications 2011 Total $39,000 40 projects 25 2012 Total $110,000 (approx) 113 projects 67 Associate Professor Steve Coverdale Acting Director, Regional Clinical Practice Research Centre -4- Centre Membership Professional, Academic and Honorary Staff Title First Name Last Name Prof Dario SORRENTINO A/Prof Steven COVERDALE A/Prof Geoffrey HAWSON A/Prof Peter T NASH A/Prof Johan VAN DEN BOGAERDE A/Prof Edward WEAVER Dr Aymen AL-TIMIMI Dr Chris ANSTEY Dr Lovell ASEERVATHAM Dr Jennifer BROOM Dr Victoria CAMPBELL Dr Christopher H CANTOR Dr James CHALLEN Dr Anthony CHAN Dr Keat CHOONG Dr Carolyn CLARK Dr James CRAIG UQ Appointment and Level , showing School/Institute Conjoint - Professor School of Medicine, Sunshine Coast Clinical School Conjoint - Associate Professor School of Medicine, Sunshine Coast Clinical School Academic Title-Associate Professor School of Medicine, Sunshine Coast Clinical School Academic Title-Associate Professor School of Medicine, Sunshine Coast Clinical School Academic Title-Associate Professor School of Medicine, Sunshine Coast Clinical School Conjoint - Associate Professor School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Conjoint - Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School -5- Hospital Appointment Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Private Practice Psychiatry Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Title First Name Last Name Dr Michelle CRONK Dr Simon DUPRE Dr Roger FAINT Dr Gordon FAULDS Dr Christine FAWCETT Dr Peter GARRETT Dr Nicholas GRAY Dr Nanu GREWAL Dr David A GRIEVE Dr Rohan GRIMLEY Dr Pamela HUDSON-JESSOP Dr Mark JOHNSON Dr Clara I J JONSSON Dr Mark D LANDY Dr Peter LARSEN Dr Chris LAWSON Dr Christopher W LILLEY Dr Jason LINDEMAN Dr Jeremy E H LONG Dr Kumaradevan MAHADEVAN UQ Appointment and Level , showing School/Institute Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Conjoint - Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Conjoint - Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School -6- Hospital Appointment Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital General Practice Buderim Marketplace Medical Centre Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital General Practice – Discipline Supervisor Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Title First Name Last Name Dr Matthew C MARRINAN Dr Craig MASKIELL Dr Tim MCNAMARA Dr Roger M J MORRIS Dr Glynn MOSELEY Dr Ian W MOTTARELLY Dr Timothy R NATHAN Dr Kenneth NG Dr David W NICHOLLS Dr Stella ROWLANDS Dr Michael J SCHOEMAN Dr Carl B SCOTT Dr Dawid SMALBERGER Dr Robyn M TAIKATO Dr James TUNGGAL Dr Yusuke UENO-DEWHIRST Dr Anne-Marie WELSH Dr Helen WESTON Dr Alexander WILLSON Dr Joseph C H WONG UQ Appointment and Level , showing School/Institute Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Adjunct Appointment – Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer - School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School -7- Hospital Appointment Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital General Practice Medicine on 2nd General Practice Nambour Clinic Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Private Practice Rheumatology Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Title First Name Last Name Dr Drasko ZEMBIC Dr Matthew AMODEO Dr Raguraman JANAKIRAMAN Dr Vikram A MASURKAR Dr Debra J TELLAM Dr Prathmesh CONTRACTOR Dr Brunhilde DAVIS Dr Thushara DISSANAYAKE Dr Elise GILBERTSON Dr Anita HARRIS Dr Rose IRON Dr Leon KITIPORNCHAI Dr Lidia KOVAL Dr Kelvin LARWOOD Dr Kim LATENDRESSE Dr Julie LEE Dr Matthew LEE-ARCHER Dr Ashish K PANIGRAHI Dr Haseeb A QURESHI Dr Jonathan ROBERTSON UQ Appointment and Level , showing School/Institute Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title - Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title - Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title - Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title - Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Academic Title - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School -8- Hospital Appointment Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Title First Name Last Name Dr Euan ROBINSON Dr Timothy J SMITH Dr Deepak L VARDESH Dr Antony J WINKEL Mr Robert PENFOLD UQ Appointment and Level , showing School/Institute Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School Industry Fellow - Clinical Librarian School of Medicine, Sunshine Coast Clinical School -9- Hospital Appointment Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Sunshine Coast Health Service District Nambour General Hospital Research Grants and Contracts Competitive Funding Years of funding Total funding ($) Amount ($) received in 2012 Grant title Granting agency / scheme Names of chief investigators UQ Admin Unit 2 $64,000 $34,500 Wishlist (Sunshine Coast) Prof Dario Sorrentino University of Queensland 1 $21,764 Approved in 2012 Wishlist (Sunshine Coast) Dr Victoria Campbell Dr Nicholas Gray N/A 1 $15,600 Approved in 2012 Human Microbial gene expression in early Crohn’s disease: clues to aetiology and pathogenesis The evaluation of midkine levels in patients with kidney disease: a pilot study Telephone versus office outpatient trial Wishlist (Sunshine Coast) Dr Nicholas Gray N/A 2 $13,837 Approved in 2012 Wishlist (Sunshine Coast) $10,000 Approved in 2012 Wishlist (Sunshine Coast) Associate Professor Steven Coverdale Dr Stella Rowlands Dr Jeremy Long N/A 1 N/A 1 $5,000 Approved in 2012 Is teaching clinical documentation on the job adequately supporting the delivery of clinical care in 2013 Prevalence of IgE to galactose-a 1,3 galactose in patients with metastatic colorectal cancer in the Sunshine Coast Health Service District Step Forward Program: Improving efficiency of care Wishlist (Sunshine Coast) Dr Christine Fawcett N/A - 10 - Years of funding Total funding ($) Amount ($) received in 2012 Grant title Granting agency / scheme Names of chief investigators UQ Admin Unit 1 $5,000 Approved in 2012 Wishlist (Sunshine Coast) Ms Suzanne Ryan Dr David Grieve N/A 1 $4,000 Approved in 2012 Clinical handover is a vital aspect of continuity of patient care. Much of the focus of recent research has explored communication practices between nursing and medical staff at the change of shift. This project aims to establish the evidence base for delineating components of the clinical handover during preparation and transfer of a patient to the operative environment. Predictors of end-stage kidney disease and mortality among patients referred to nephrology outpatient clinics Wishlist (Sunshine Coast) Dr Christine Sammartino Dr Nicholas Gray N/A - 11 - Research Publications Peer Reviewed Publications Journal (peer reviewed) A case of bilateral lower cranial nerve palsies after base of skull trauma With complex management issues case report and review of the literature. Lehn, Alexander Christoph, Lettieri, Jennie and Grimley, Rohan Neurologist (2012), 18 3: 152-154. A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits. Ma, Henry, Parsons, Mark W., Christensen, Soren, Campbell, Bruce C. V., Churilov, Leonid, Connelly, Alan, Yan, Bernard, Bladin, Chris, Phan, Than, Barber, Alan P., Read, Stephen, Hankey, Graeme J., Markus, Romesh, Wijeratne, Tissa, Grimley, R., Mahant, N., Kleinig, Tim, Sturm, John, Lee, A., Blacker, D., Gerraty, Richard, Krause, M., Desmond, P. M., McBride, S. J., Carey, Leanne, Howells, David W., Hsu, C. Y., Davis, Stephen M. and Donnan, Geoffrey A. International Journal of Stroke (2012), 7 1: 74-80. A randomised controlled trial of Heparin versus EthAnol Lock THerapY for the prevention of Catheter Associated infecTion in Haemodialysis patients – the HEALTHY-CATH trial. Jennifer K Broom, Rathika Krishnasamy, Carmel M Hawley, E Geoffrey Playford and David W Johnson. BMC Nephrology 2012 Nov 2;13:146. Anti-TNFs for prevention of postoperative recurrence of Crohn's disease: A broken record?. Sorrentino, Dario Inflammatory Bowel Diseases (2012), 18 9: 1624-1625. Atypical fractures associated with bisphosphonate use post renal transplantation. Burke MT, Hollett PR, Gray NA. Nephrology 2012; 17 (Supp 1): 1-4 Bringing top end endoscopy to regional Australia: hurdles and benefits. Van den Bogaerde J., Sorrentino D. Diagn Ther Endosc. 2012;2012:347202 Carcinoid tumour management in haemodialysis: a case report. Burke MT, Gray NA. Nephrology 2012; 17(2): 198 - 12 - Clinical remission after stopping infliximab in Crohn's Disease: Is all that glitters true gold?. Sorrentino, Dario and Radford-Smith, Graham Gastroenterology (2012), 142 5: E17-E17. Coccidioidomycosis in returned immunocompetent Australian Travellers. Subedi Shradha, Broom Jennifer, Sowden David, Bint Michael and Caffery Michael. Internal Medicine Journal. 2012 Aug;42(8):940-3 Computed tomography-based sizing recommendations for transcatheter aortic valve replacement with balloon-expandable valves: Comparison with transesophageal echocardiography and rationale for implementation in a prospective trial Willson, Alexander B.; Webb, John G.; Freeman, Melanie; et al. Journal of Cardiovascular Computed Tomography Volume: 6 Issue: 6 Pages: 406-414 Published: NOV-DEC 2012 Dialysis in public and private hospitals in Queensland. Gray NA, Dent H, McDonald SP. Internal Medicine Journal 2012; 42(8): 887-893 Early diagnosis and treatment of postoperative endoscopic recurrence of Crohn's disease: partial benefit by infliximab--a pilot study. Sorrentino D, Terrosu G, Paviotti A, Geraci M, Avellini C, Zoli G, Fries W, Danese S, Occhipinti P, Croatto T, Zarifi D. Dig Dis Sci. 2012 May;57(5):1341-8 Impact of tactile dysfunction on upper-limb motor performance in children with unilateral cerebral palsy. Auld, Megan, Boyd, Roslyn, Moseley, G. Lorimer, Ware, Robert S. and Johnston, Leanne M. Archives of Physical Medicine And Rehabilitation (2012), 93 4: 696-702. Immunogenicity, safety and efficacy of abatacept administered subcutaneously with or without background methotrexate in patients with rheumatoid arthritis: Results from accompany, a phase III study. Nash P, Nayiager S, Genovese MC, Kivitz AJ, Oelke K, Ludivico C, Palmer W, Rodriguez C, Delaet I, Elegbe A, Corbo M. Arthritis Care Res (Hoboken). 2012 Oct 24. doi: 10.1002/acr.21876. [Epub ahead of print] Intensive Enough?. Campbell, Victoria New England Journal of Medicine (2012), 366 22: 2124-2125. Living donor registries are needed. Sammartino C, Clark C, Gray N. BMJ 2012; 344: e2727 Long Term Survival in HIV positive patients with up to 15 years of Antiretroviral Therapy. McManus H, O’Connor CC, Boyd M, Broom J, Russell D, Watson K, Roth N, Read PJ, Petoumenos K, Law M on Behalf of the Australian HIV Observational Database (AHOD) PLoS One. 2012;7(11) - 13 - Moving from Viral Suppression to Comprehensive Patient-Centered Care: The High Prevalence of Comorbid Conditions and Health Risk Factors in HIV-1-Infected Patients in Australia. Broom J, Sowden, D, Williams M, Taing K, Morwood K, and McGill K. J Int Assoc Physicians AIDS Care (Chic). 2012 Mar-Apr;11(2):109-14. Mucosal healing and clinical remission in inflammatory bowel diseases: Are we missing something here? Sorrentino D. Inflamm Bowel Dis. 2012 Apr 19 doi: 10.1002/ibd.22999. N-terminal pro-brain natriuretic peptide in a novel screening algorithm for pulmonary arterial hypertension in systemic sclerosis: a casecontrol study. Thakkar V, Stevens WM, Prior D, Moore OA, Byron J, Liew D, Patterson K, Hissaria P, Roddy J, Zochling J, Sahhar J, Nash P, Tymms K, Celermajer D, Gabbay E, Youssef P, Proudman SM, Nikpour M. Arthritis Res Ther. 2012 Jun 12;14(3):R143. doi: 10.1186/ar3876. Percutaneous Aortic Valve Replacement Toggweiler, Stefan; Gurvitch, Ronen; Leipsic, Jonathon; et al. (Alexander Willson) Journal of the American College of Cardiology Volume: 59 Issue: 2 Pages: 113-118 Published: JAN 10 2012 Predictive value according to location of incidental focal colorectal fluorodeoxyglucose uptake on positron emission tomography scans. Lee, J. C., Hartnett, G. F. and Ravi Kumar, A. S. Colorectal Disease (2012), 14 5: 642-643. Prevalence, correlates and clinical usefulness of antibodies to RNA polymerase III in systemic sclerosis: a cross-sectional analysis of data from an Australian cohort. Nikpour M, Hissaria P, Byron J, Sahhar J, Micallef M, Paspaliaris W, Roddy J, Nash P, Sturgess A, Proudman S, Stevens W Arthritis Res Ther. 2011;13(6):R211. doi: 10.1186/ar3544. Epub 2011 Dec 22. Renal replacement therapy in rural and urban Australia. Gray NA, Dent H, McDonald SP. Nephrol Dial Transplant 2012; 27(5): 2069-2076 Recommendations for the treatment of Crohn's disease with tumor necrosis factor antagonists: An expert consensus report. Feagan, Brian G., Lemann, Marc, Befrits, Ragnar, Connell, William, D'Haens, Geert, Ghosh, Subrata, Michetti, Pierre, Ochsenkuhn, Thomas, Panaccione, Remo, Schreiber, Stefan, Silverberg, Mark, Sorrentino, Dario, van der Woude, C. Janneke, Vermeire, Severine and Rutgeerts, Paul Inflammatory Bowel Diseases (2012), 18 1: 152-160. Recommendations for the treatment of ulcerative colitis with infliximab: A gastroenterology expert group consensus. Reinisch, Walter, Van Assche, Gert, Befrits, Ragnar, Connell, William, D'Haens, Geert, Ghosh, Subrata, Michetti, Pierre, Ochsenkuhn, Thomas, Panaccione, Remo, Schreiber, Stefan, Silverberg, Mark S., Sorrentino, Dario, van der Woude, Janneke, Vermeire, Séverine and Panes, Julian Journal of Crohns and Colitis (2012), 6 2: 248-258. Reproducibility of tactile assessments for children with unilateral cerebral palsy. Auld, Megan Louise, Ware, Robert S., Boyd, Roslyn Nancy, Moseley, G.Lorimer and Johnston, Leanne Marie Physical and Occupational Therapy in Paediatrics (2012), 32 2: 151-166. - 14 - Sex Differences in Mortality After Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis Humphries, Karin H.; Toggweiler, Stefan; Rodes-Cabau, Josep; et al. (Alexander Willson) Journal of the American College of Cardiology Volume: 60 Issue: 10 Pages: 882-886 Published: SEP 4 2012 Structural Integrity of Balloon-Expandable Stents After Transcatheter Aortic Valve Replacement Assessment by Multidetector Computed Tomography Willson, Alexander B.; Webb, John G.; Gurvitch, Ronen; et al. Jacc-Cardiovascular Interventions Volume: 5 Issue: 5 Pages: 525-532 Published: MAY 2012 Tactile function in children with unilateral cerebral palsy compared to typically developing children. Auld, Megan Louise, Boyd, Roslyn, Moseley, G. Lorimer, Ware, Robert and Johnston, Leanne Marie Disability and Rehabilitation (2012), 34 17: 1488-1494. The development of candidate composite disease activity and responder indices for psoriatic arthritis. Helliwell, P.S., FitzGerald, O., Fransen, J., Gladman, D.D., Kreuger, G.G., Callis-Duffin, K., McHugh, N., Mease, P.J., Strand, V., Waxman, R., Azevedo, V.F., Ostos, A.B., Carneiro, S, Cauli, A., Espinoza, L.R., Flynn, J.A., Hassan, N., Healy, P., Kerzberg, E.M., Lee, Y.J., Lubrano, E., Marchesoni, A., Marzo-Ortega, H., Porru, G., Moreta, E.G., Nash, P., Raffayova, H., Ranza, R., Raychaudhuri, S.P., Roussou, E., Scarpa, R., Song, Y., Soriano, E., Tak, P.P., Ujfalussy, I., de Vlam, K. and Walsh, J.A. (2012) Annals of the Rheumatic Diseases, in press The race for mainstream gastrointestinal endoscopy: frontrunners. Seltenreich, H., Van den Bogaerde, J. and Sorrentino, D. Expert Review of Gastroenterology and Hepatology (2012), 6 4: 467-479. The role of magnetic resonance imaging in detecting intestinal fibrosis in Crohn's disease. Fiorino, Gionata, Cesarini, Monica, Malesci, Alberto, Danese, Silvio and Sorrentino, Dario Current Drug Targets (2012), 13 10: 1273-1279. The use of Key Performance Indicators to benchmark individual clinic performance in the management of a complex chronic infectious disease. Kelly M, Broom J, Young S. Med J Aust. 2012 Sep 17;197(6):330-1 Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. van Vollenhoven RF, Fleischmann R, Cohen S, Lee EB, GarcÃa Meijide JA, Wagner S, Forejtova S, Zwillich SH, Gruben D, Koncz T, Wallenstein GV, Krishnaswami S, Bradley JD, Wilkinson B; ORAL Standard Investigators (Peter Nash) N Engl J Med. 2012 Aug 9;367(6):508-19. doi: 10.1056/NEJMoa1112072. Transcatheter Aortic Valve Replacement Outcomes of Patients With Moderate or Severe Mitral Regurgitation Toggweiler, Stefan; Boone, Robert H.; Rodes-Cabau, Josep; et al. (Alexander Willson) Journal of the American College of Cardiology Volume: 59 Issue: 23 Pages: 2068-2074 Published: JUN 5 2012 - 15 - Transcatheter Aortic Valve Replacement With the St. Jude Medical Portico Valve First-in-Human Experience Willson, Alexander B.; Rodes-Cabau, Josep; Wood, David A.; et al. Journal of the American College of Cardiology Volume: 60 Issue: 7 Pages: 581-586 Published: AUG 14 2012 Transcatheter Valve-In-Valve Implantation for Failed Balloon-Expandable Transcatheter Aortic Valves Toggweiler, Stefan; Wood, David A.; Rodes-Cabau, Josep; et al. (Alexander Willson) Jacc-Cardiovascular Interventions Volume: 5 Issue: 5 Pages: 571-577 Published: MAY 2012 Book chapter Anti-TNF’s for prevention of postoperative recurrence of Crohn’s disease: The state of the art. Sorrentino D. Buckton S. From: Medrano Acevedo AD and Fajardo Gaitan M. Editors: Infliximab: Pharmacology, Uses and Limitations. Nova Science Publishers, Inc., Hauppauge, NY, USA 2012 pp 135-150. Diagnosis and assessment of Crohn’s disease. Hilton D, Marr K, Sandford A, Van den Bogaerde J. Sorrentino D. From: LeBlanc, J.G., de Moreno de LeBlanc, A. Editors: Crohn’s Disease: Etiology, Diagnosis and Treatment Options, Nova Science Publishers, Inc., Hauppauge, NY, USA 2012 pp 39-57 Innovative Uses and Emerging Technologies in Endoscopy. Van den Bogaerde J., Sorrentino D. From Endoscopy / Book 2", ISBN 980-953-307-457-8. Open Science Publisher 2012 Published abstract Analysis of plasma biomarkers potentially associated with antiangiogenic resistance in NCIC CTG/AGITG CO.20: A phase III randomized trial of cetuximab (CET) plus either brivanib alaninate (BRIV) or placebo in patients (pts) with chemotherapy refractory, k-RAS wild-type (WT), metastatic colorectal carcinoma (mCRC). Jeremy David Shapiro, Lillian L. Siu, Christopher J O'Callaghan, John Raymond Zalcberg, Malcolm J. Moore, Timothy Jay Price, Catherine Doyle, John Simes, Brian Peter Findlay, Michelle F. Cronk, Asif Shaikh, Warren Lance Joubert, Benoit Samson, Antonino Bonaventura, Craig Underhill, David Wyld, Ian B. Walters, Penny Phillips, Dongsheng Tu, Derek J. Jonker, and NCIC CTG AND AGITG Journal of Clinical Oncology, 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition). Vol 30, No 15_suppl (May 20 Supplement), 2012: TPS4137 Anti-glomerular basement membrane disease occurring during pregnancy. O’Shea S, Francis R, Sammartino C, Ratanjee S, Gray N. Nephrology 2012; 17(Sup 2): A44 Does prescribed and delivered haemodialysis treatment time differ? Noble E, Sullivan M, Gray NA. Nephrology 2012; 17(Sup 2): A41 FIRST-IN-MAN TRANSFEMORAL TRANSCATHETER AORTIC VALVE REPLACEMENT WITH THE 29MM EDWARDS SAPIEN XT VALVE Freeman, M.; Rodes-Cabau, J.; Alcazar, M. Urena; et al. (Alexander Willson) Canadian Journal of Cardiology Volume: 28 Issue: 5 Pages: S252-S253 Published: SEP-OCT 2012 - 16 - PAN1: A randomized phase II study evaluating potential predictive biomarkers in the treatment of metastatic pancreatic cancer. Yu Jo Chua, Christos Stelios Karapetis, Craig Underhill, Louise M. Nott, David Goldstein, Michelle F. Cronk, Val Gebski, Nicole Wong, Katrin Marie Sjoquist, Andrew Victor Biankin and Australasian Gastrointestinal Trials Group (AGITG) Journal of Clinical Oncology, 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition). Vol 30, No 15_suppl (May 20 Supplement), 2012: TPS4137 Patient information about options for treatment (PINOT) follow up study: answering important questions in home dialysis and conservative care. Morton R, Connolly M, Snelling P, Gray N, Webster A, Howard K, McGeechan K, Kerr P. Nephrology 2012; 17(Sup 2): A99 Peritoneal dialysis in rural Australia. Gray NA, Grace B, McDonald SP. Nephrology 2012; 17(Sup 2): A136 Safety profile of subcutaneous abatacept focusing On clinically relevant events in patients with rheumatoid arthritis and up to 4.5 years of exposure Alten, Rieke, Kaine, Jeffrey L., Keystone, Edward, Nash, Peter T., Delaet, Ingrid, Qi, Keqin and Genovese, Mark C. In: Rheumatology 2012 Abstracts: Poster Viewing II. Annual Meeting of the British-Society-for-Rheumatology, Glasgow, Scotland, (127-128). 1 - 3 May 2012 THREE-DIMENSIONAL AORTIC ANNULAR ASSESSMENT BY MULTIDETECTOR COMPUTED TOMOGRAPHY PREDICTS MODERATE OR SEVERE PARAVALVULAR REGURGITATION AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT: A MULTICENTER RETROSPECTIVE ANALYSIS Willson, Alex; Webb, John; LaBounty, Troy; et al. Journal of the American College of Cardiology Volume: 59 Issue: 13 Pages: E325-E325 Published: MAR 27 2012 Transcatheter Aortic Valve Replacement with a New Self-expanding Percutaneous Heart Valve and Motorized Delivery System Binder, Ronald; Schaefer, Ulrich; Kuck, Karl-Heinz; et al. (Alexander Willson) Journal of the American College of Cardiology Volume: 60 Issue: 17 Pages: B233-B233 Published: OCT 23 2012 Conference Paper (peer reviewed) A Longitudinal Study of Prognostic Factors in Patients with Early RA Providing Direction for Future Clinical Treatment- Predict Study. Bird P, Nicholls D, de Jager J, Griffiths H, Roberts L, Tymms K, Zochling J, Arnold M, Littlejohn G. In: ACR/ARHP Annual Meeting (2012) Washington, D.C., November 9-14, 2012 A retrospective chart review of Mabthera (rituximab) for rheumatoid arthritis in Australian rheumatology practice. Nicholls, D. Australian Rheumatology Association Annual Scientific Meeting Canberra 2012 – Clinical Free Paper A survey study of methotrexate use by rheumatologists and their patients with rheumatoid arthritis. Nash, Peter and Nicholls, Dave In: Abstracts of the American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting (2012). Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, (S670-S670). 9-14 November 2012. - 17 - Australian psoriasis treatment goals project. Foley, P., Baker, C., Cooper, A., Chan, J., Fischer, G., Soyer, H. P., Shumack, S., Sidhu, S., Wu, J., Nash, P., Rawlin, M. and Radulski, B. In: The Australasian College of Dermatologists 45th Annual Scientific Meeting (2012). The Australasian College of Dermatologists 45th Annual Scientific Meeting, Brisbane, Australia, (18-19). 20-23 May 2012. DAS in Australian RA patients inversely relates to socioeconomic status. Arnold M, Franklyn K, Scott J, Bird P, de Jager J, Griffiths H, Littlejohn G, Nicholls D, Roberts L, Tymms K, Zochling J. In: Australian Rheumatology Association Annual Scientific Meeting Canberra 2012 Efficacy, safety and pharmacokinetics of subcutaneous abatacept in patients with rheumatoid arthritis, with or without an intravenous loading dose. Nash, Peter T., Ludivico, Charles L., Delaet, Ingrid, Qi, Keqin, Murthy, Bindu, Corbo, Michael and Kaine, Jeffrey L. In: Rheumatology 2012 Abstracts (2012). Annual Meeting of the British-Society-for-Rheumatology, Glasgow Scotland, (iii133-iii134). May 1-3 2012. Efficacy, safety and pharmacokinetics of subcutaneous abatacept in patients with rheumatoid arthritis, with or without an intravenous loading dose. Nash, P., Ludivico, C., Delaet, I., Qi, K., Murthy, B., Corbo, M. and Kaine, J. In: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting (2012). Australian Rheumatology Association in Conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting, Canberra, Australia, (12-12). 1215 May 2012. Impact of etanercept-methotrexate therapy on patient-reported outcomes in moderately active rheumatoid arthritis: Australian results from the induction period of preserve trial. Nash, P., Hall, S., Bird, P., Bananis, E., Koenig, A., Szumski, A., Jones, H., Kotak, S., Witcombe, D. and Thirunavukkarasu, K. In: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting (2012). Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting, Canberra, ACT, Australia, (1213). 12-15 May 2012. Long-term safety of tocilizumab in rheumatoid arthritis clinical trials. Taylor, A., Nash, P., Hall, S., Jones, G., Youssef, P., Porter-Brown, B., Thompson, L. and Genovese, M. In: Special Issue: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting (2012). 53rd Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals, Canberra ACT, Australia, (14-14). 12-15 May 2012. Matrix: Mapping Australian Treatment Reality Involving Methotrexate (mtx), a Survey Study of Rheumatologists and Their Patients with Rheumatoid Arthritis (ra). Nash, P. and Nicholls, D. In: Special Issue: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting (2012). 53rd Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals, Canberra ACT, Australia, (13-13). 12-15 May 2012. Medication Choices and Medication Survival in a National Multi-centre Community Based Rheumatoid Arthritis Cohort Roberts L, Tymms K, de Jager J, Littlejohn G, Griffiths H, Nicholls D, Bird P, Hill J, McCloud P, Scott J, Zochling J, on behalf of the OPAL consortium. In: 2012 ACR/ARHP Annual Meeting, Washington, D.C., November 9-14, 2012 - 18 - Patient information about options for treatment (PINOT) follow up study: answering important questions in home dialysis and conservative care. Morton, R., Connolly, M., Snelling, P., Gray, N., Webster, A., Howard, K., McGeechan, K. and Kerr, P. In: Special Issue: Abstracts of the 48th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (2012). 48th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Auckland, (53-53). 27-29 August 2012. Prolonged exposure to subcutaneous and intravenous abatacept in patients with rheumatoid arthritis does not affect rates of infection, malignancy and autoimmune events: results from pooled clinical trial data. Genovese, M. C., Hochberg, M. C., Cohen, R. B., Weinblatt, M. E., Kaine, J., Keystone, E., Nash, P., Delaet, I. and Alten, R. In: Abstracts of the American College of Rheumatology & Association of Rheumatology Health Professionals (2012), Annual Scientific Meeting. Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, (S725-S725). 9-14 November 2012. Subcutaneous abatacept: long-term data from the Acquire Trial. Genovese, M. C., Pacheco-Tena, C., Covarrubias, A., Leon, G., Mysler, E., Keiserman, M., Valente, R., Nash, P., Simon-Campos, J. A., Box, J., Legerton, C., III, Nasonov, E., Durez, P., Delaet, I. and Alten, R. In: Abstracts of the American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting (2012). Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, (S201-S201). 9-14 November 2012. Subcutaneous abatacept versus intravenous abatacept in patients with rheumatoid arthritis: Long-term data from the acquire trial. Genovese, Mark C., Cobos, Arturo, Leon, Gustavo, Mysler, Eduardo F., Keiserman, Mauro W., Valente, Robert M., Nash, Peter T., Campos, J. Abraham Simon, Porawska, Wiewlsawa, Box, Jane H., Legerton, Clarence W., Nasonov, Evgeny L., Durez, Patrick, Pappu, Ramesh, Delaet, Ingrid, Teng, Julie and Alten, Rieke In: Rheumatology 2012 Abstracts: Poster Viewing II. Annual Meeting of the British-Society-for-Rheumatology, Glasgow, Scotland, (128-129). 1 - 3 May 2012. Safety profile of subcutaneous abatacept focusing On clinically relevant events in patients with rheumatoid arthritis and up to 4.5 years of exposure. Alten, Rieke, Kaine, Jeffrey L., Keystone, Edward, Nash, Peter T., Delaet, Ingrid, Qi, Keqin and Genovese, Mark C. In: Rheumatology 2012 Abstracts: Poster Viewing II (2012). Annual Meeting of the British-Society-for-Rheumatology, Glasgow, Scotland, (127-128). 1 - 3 May 2012. Tofacitinib (cp-690,550), an oral Janus Kinase Inhibitor: Pooled phase 3 analysis in an Australian Rheumatoid Arthritis Study Population. Hall, S., Nash, P., Rischmueller, M., Bossingham, D., Cook, N., Kwok, K. and Thirunavukkarasu, K. In: Special Issue: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting (2012). 53rd Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals, Canberra ACT, Australia, (14-14). 12-15 May 2012. - 19 - Weekly subcutaneous abatacept confers comparable onset of treatment response and magnitude of efficacy improvement over 6 months when administered with or without an intravenous abatacept loading dose. Schiff, M., Alten, R., Weinblatt, M., Nash, P., Fleischmann, R., Durez, P., Kaine, J., Delaet, I., Kelly, S., Maldonado, M., Patel, S. and Genovese, M. C. In: Abstracts of the American College of Rheumatology & Association of Rheumatology Health Professionals (2012), Annual Scientific Meeting. Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, (S1076-S1076). 9-14 November 2012. Approved Research HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: HREC/04/QRBW/205 A phase III trial evaluating the role of ovarian function suppression and the role of Exemestane as adjuvant therapies for premenopausal women with endorcrine responsive breast cancer: Suppression of Ovarian Function Trial (SOFT) 2006 Drug Trial Geoffrey Hawson Geoffrey Hawson HREC/05/QRBW/35 IST-3: The Third International Stroke Trial (IST-3) of thrombolysis for acute ischaemic stroke. An international multi-centre, randomised, controlled trial to investigate the safety and efficacy of treatment with intravenouse recombinant tissue plasminogen activator (rt-PA) within six hours of onset of acute ischaemic stroke Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: Other Trial Rohan Grimley Rohan Grimley HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/07/QRBW/169 A phase 3, multi-centre randomized controlled trial of very early rehabilitation after stroke (AVERT) 2008 Other Trial Rohan Grimley Rohan Grimley - 20 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/08/QPAH/168 To implement an evidence based falls clinic and determine its effectiveness in reducing falls and fall related injuries 2008 Clinical Research Christine Fawcett Christine Fawcett Chris Bourke Jeremy O'Leary Michael Creen HREC Reference: Trial Name: HREC/08/QTDD/35 CARIATIDE : Compliance of ARomatase Inhibitors AssessmenT In Daily practice through educational approach. A multi-country, observational study to evaluate the impact of educational material on the compliance and persistence rates to adjuvant aromatase inhibitor (AI) medication for post-menopausal women with hormone sensitive early breast cancer 2008 Trial Clinical Michelle Cronk Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/09/QNRC/15 A double blind randomised trial of cediranib versus placebo in patients receiving paclitaxel / carboplatin chemotherapy for the treatment of advanced or metastatic non-small cell lung cancer 2009 Drug Trial Jeremy Long Jeremy Long Michelle Cronk Geoffery Hawson HREC/09/QNRC/17 A randomised, placebo controlled trial of oxpentifylline on haemoglobin levels in patiens with erythropoietin resistant anaemia 2009 Drug Trial Kumar Mahadevan Kumar Mahadevan Nicholas Gray Euan Nobel Peter Hollett - 21 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/09/QNRC/32 A randomised double-blind, placebo-controlled study of everolimus in combination with exemestane in the treatment of postmenopausal women with estrogen receptor positive, locally advanced or metastatic breast cancer who are refractory to letrozole or anas 2009 Drug Trial Michelle Cronk Michelle Cronk Jeremy Long Geoffrey Hawson HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/09/QNRC/34 CONCORDANCE - Cooperative National Registry of Acute Coronary Care Guideline Adherence and Clinical Events 2009 Clinical Research Steven Coverdale Steven Coverdale Matthew Marrinan HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/09/QNRC/5 A phase III randomised trial of adding niroglycerin to first line chemotherapy for advanced non-small cell lung cancer 2009 Drug Trial Jeremy Long Jeremy Long Michelle Cronk Geoffery Hawson HREC Reference: Trial Name: HREC/09/QNRC/56 ACTIVE Dialysis: A clinical trial of intensive dialysis. A multi-centre unblinded randomised controlled trial to assess quality of life, clinical outcomes and cost utility for extended versus standard duration of dialysis in patients with ESKD 2009 Other Trial Nicholas Gray Kumar Mahadevan Nicholas Gray Euan Nobel Peter Hollett Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: - 22 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/09/QNRC/59 Prostatectomy Patient Education Program Research Project 2010 Health Research Tim Nathan Tim Nathan Erica Mohr Sue Torr John Buchanan HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/09/QNRC/71 SCOT - Short Course Oncology Therapy, A study of adjuvant chemotherapy in colorectal cancer 2010 Drug Trial Michelle Cronk Jeremy Long Michelle Cronk Geoffery Hawson HREC Reference: Trial Name: HREC/09/QNRC/72 A multicenter, randomized, double-blind, placebo-controlled study to evaluate cardiovascular outcomes following treatment with alogliptin in addition to standard of care in subjects with Type 2 Diabetes and Acute Coronary Syndrome: EXAMINE 2010 Drug Trial Steven Coverdale Steven Coverdale Matthew Marrinan Steven Hamwood Shyam Sunder Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/09/QNRC/74 Program for the assessment of clinical cancer tests (PACCT-1): Trial assigning individualized options for treatment (The TAILORx Trial) ANZ 0901 2010 Other Trial Michelle Cronk Jeremy Long Michelle Cronk Geoffery Hawson - 23 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/09/QNRC/75 Multinational, randomized, double-blind, phase III study of IMC-1121B plus Docetaxel vs Placebo plus Docetaxel in previously untreated patients with HER2-Negative, unresectable, locally-recurrent or metastatic breast cancer: TRIO-012 (ANZ 0802) 2010 Drug Trial Michelle Cronk Jeremy Long Michelle Cronk Geoffery Hawson HREC/10/QGC/114 Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Comparing REMICADE® (infliximab) and Placebo in the Prevention of Recurrence in Crohn’s Disease Patients Undergoing Surgical Resection Who Are at an Increased Risk of Recurrence 2010 Drug Trial Dario Sorrentino Dario Sorrentino Hansjoerg Seltenreich Ratna Aseervatham HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/10/QGC/129 Paroxysmal Nocturnal Haemoglobinuria (PNH) Registry 2012 Clinical Research Christine Lambooy Christine Lambooy Helen Weston HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/10/QHC/41 Chronic kidney disease Queensland (CKD.QLD) database and registry 2011 Clinical Research Nicholas Gray Kumar Mahadevan Nicholas Gray Euan Nobel Peter Hollett Victoria Campbell - 24 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/10/QHC/51 Discovery Interviews: Consumer, Carer and Clinician perceptions and experiences of Queensland Health Services 2011 Health Research Shoni Colquist Nicholas Gray HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/10/QNRC/29 A survey of knowledge about chronic kidney disease among nephrology outpatients 2010 Health Research Nicholas Gray Nicholas Gray HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/10/QPCH/126 Evaluation of the Safety and Efficacy of Short-term A-002 Treatment in Subjects with Acute Coronary Syndromes 2010 Drug Trial Peter Larsen Peter Larsen Matthew Marrinan HREC Reference: Trial Name: HREC/10/QPCH/165 A Double Blind Placebo Controlled Randomized Trial Of Pf-00299804 (PF-804) In Patients With Incurable Stage Iiib/Iv Non-Small Cell Lung Cancer After Failure Of Standard Therapy For Advanced Or Metastatic Disease 2011 Drug Trial Geoffrey Hawson Geoffrey Hawson Jeremy Long Michelle Cronk Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: - 25 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/10/QPCH/84 Procalcitonin Guided Antibiotic Rational Decision Making in ICU Patients (ProGUARD) 2011 Other Trial Peter Garrett Peter Garrett Vikram Masurkar Chris Anstey Gerard Joyce Mark Landy Victoria Campbell Carl Scott Chris Graves HREC Reference: Trial Name: HREC/10/QRBW/238 An assessment of the difference in elapsed time to re-excision in breast conserving surgery between public and private patients in the Nambour region 2010 Health Research David Grieve David Grieve Matthew Solomon Colin Cochrane Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/10/QRBW/302 A Multicentre, Randomised, Double-Blind, Placebo-controlled Phase Iib Study to Compare the Efficacy and Safety of Two dosing Regimens of Intravenouse Infusions of CytoFab TM (AZD9773) in Adult Patients with severe Sepsis and/or Septic Shock 2011 Drug Trial Peter Garrett Peter Garrett Vikram Masurkar Chris Anstey Gerard Joyce Mark Landy Victoria Campbell Chris Graves - 26 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/10/QRBW/341 Stroke imaging prevention and treatment (START) EXTEND: Extending the time for thrombolysis in emergency neurological deficits 2010 Drug and Device Trial Rohan Grimley Rohan Grimley Mark Denhan Antony Tampiyappa Tomin Mooney HREC Reference: Trial Name: HREC/11/QGC/134 TR701-113 A phase 3 randomised, double-blind, multicentre study comparing the efficacy and safety of intravenous to oral 6-day TR-701 Free Acid and intravenous to oral 10 day Linezolid for the treatment of acute bacterial skin and skin structure infection 2012 Drug Trial David Sowden David Sowden Jennifer Broom Keat Choong Matthew Amodeo Andrew Henderson Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QNRC/12 Improving the practice of nutrition therapy in the critically ill: International Nutrition Survey 2011 Clinical Research Peter Garrett Peter Garrett Shona McDonald Anne Buckley HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QNRC/37 Patient satisfaction with the inpatient services on the Surgival Ward at Nambour General Hospital 2011 Clinical Research David Grieve David Grieve Lidia Koval Nai Kid Lai - 27 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QNRC/38 Efficacy of the current plaster splinting in providing pain relief for patients with acute fractures of the ankle: a single centre experience 2011 Clinical Research Kim Latendresse Kim Latendresse Lidia Koval James Tunggal HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QNRC/58 Non fixation of mesh in open inguinal hernia repair - single surgeon experience 2011 Clinical Research David Grieve David Grieve Thushara Dissanayake Nicolas Copertino Ratna Aseervatham HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QNRC/59 Patterns of injury in trauma patients requiring inter-hospital transfer from a major regional hospital to its tertiary referring facilities 2012 Clinical Research Kevin Chan Kevin Chan David Grieve HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QNRC/73 A prospective audit of the use and utility of diagnostic imaging in the diagnosis and management of acute appendicitis 2011 Health Research David Grieve David Grieve Emily Hales - 28 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QNRC/9 ICU Nursing Clinical Scenario - Identifying and managing a potential organ donor 2011 Clinical Research Susan Priebe Susan Priebe Jenny Jaspers Peter Garrett Shona McDonald Mark Kelly Danielle Jackson HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QPAH/121 A randomised phase II study evaluating potential predictive biomarkers in the treatment of metastatic pancreatic cancer 2011 Drug Trial Michelle Cronk Michelle Cronk Jeremy Long Geoffrey Hawson HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QPAH/170 A Trial in the Timing of Surgery and Adjuvant Chemotherapy for Hepatic Metastases from Colorectal Cancer 2011 Drug Trial Michelle Cronk Michelle Cronk Jeremy Long Geoffrey Hawson Ratna Aseervatham HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QPAH/300 The influence of host genetics and viral factors in chronic hepatitis C infection. ML25629 2012 Clinical Research Andrew Sloss Andrew Sloss Nicola Weston Johan van den Bogaerde - 29 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QPAH/335 Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Safety and Efficacy of Ustekinumab Induction Therapy in Subjects with Moderately to Severely Active Crohn’s Disease Who Have Failed or Are Intolerant 2012 Drug Trial Dario Sorrentino Dario Sorrentino Stephanie Buckton Andrew Sloss Hansjorg Seltenreich HREC/11/QPAH/336 A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Safety and Efficacy of Ustekinumab Induction Therapy in Subjects with Moderately to Severely Active Crohn’s Disease 2012 Drug Trial Dario Sorrentino Dario Sorrentino Stephanie Buckton Andrew Sloss Hansjorg Seltenreich HREC/11/QPAH/337 A Phase 3, Randomized, Double-blind, Placebo controlled, Parallel-group, Multicenter Study to Evaluate the Safety and Efficacy of Ustekinumab Maintenance Therapy in Subjects with Moderately to Severely Active Crohn’s Disease 2012 Drug Trial Dario Sorrentino Dario Sorrentino Stephanie Buckton Andrew Sloss Hansjorg Seltenreich - 30 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QPAH/358 Bardoxolone methyl evaluation in patients with chronic kidney disease and type 2 diabetes: the occurrence of renal events 2012 Drug Trial Nicholas Gray Nicholas Gray Peter Hollett Kumar Mahadevan Euan Noble Victoria Campbell HREC Reference: Trial Name: HREC/11/QPAH/400 A randomised, open-label study to evaluate the efficacy and safety of maraviroc (MVC) as a switch for N(t)RTI or PI/r in HIV-1 infected individuals with stable, well-controlled plasma HIV-RNA while taking their first N(t)RTI+PI/r regimen of cART 2012 Drug Trial David Sowden David Sowden Kuong Taing Jennifer Broom Karen Morwood Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QPAH/619 A randomised blinded placebo controlled trial of hydrocortisone in critically ill patients with septic shock (ADRENAL Study) 2012 Drug Trial Peter Garrett Peter Garrett Vikram Masurkar Anne-Marie Welsh Mark Landy - 31 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QPCH/14 Multicentre, Single-arm, Open Label Clinical Trial Intended to Provide Early Access to Cabazitaxel in Patients with Metastatic Hormone Refractory Prostate Cancer Previously Treated with a Docetaxel-Containing Regimen and document safety of Cabazitaxel in 2011 Drug Trial Michelle Cronk Michelle Cronk Jeremy Long Geoffrey Hawson HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QPCH/187 The tyranny of distance: exploring contributory factors for delays in transfer and intervention in multi-trauma patients 2012 Clinical Research Martin Wullschleger Peter Garrett HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QPCH/199 Local staging of prostate cancer with 3T MRI 2012 Clinical Research James Challen James Challen David O'Regan Alex Splatt HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QPCH/33 HIV in Queensland: 2011 2011 Clinical Research Kuong Taing Kuong Taing David Sowden Jennifer Broom Karen Morwood - 32 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QRBW/12 Australian Stroke Clinical Register: AuSCR Queensland 2011 Clinical Research Rohan Grimley Rohan Grimley Anthony Tampiyappa Donna Rowley Eva Salud HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QRBW/148 Too much, too soon? The impact of treatment-focused genetic testing in patients newly diagnosed with breast cancer 2011 Clinical Research David Grieve David Grieve Karen Crowe HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QRBW/150 Prolonged Outcome Study - Renal 2011 Clinical Research Peter Garrett Peter Garrett Victoria Campbell HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QRBW/239 Gabapentin for taxane acute pain syndrome - a phase III randomised, placebo-controlled, crossover trial 2011 Drug Trial Jeremy Long Jeremy Long Michelle Cronk Peter Smith Christine Cocks - 33 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QRBW/243 The evaluation of tele health support services for patients with head and neck cancer 2011 Health Research Clare Burns Karen Malcolm HREC Reference: Trial Name: HREC/11/QRBW/300 Phase II study of aromatase inhibitors in women with potentially hormone responsive recurrent/metastatic gynaecological neoplasms: PARAGON 2012 Drug Trial Michelle Cronk Michelle Cronk Jeremy Long Geoffrey Hawson Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QRCH/181 Magnesium sulphate at 30 to 34 weeks gestational age: Neuroprotection Trial 2012 Drug Trial Edward Weaver Edward Weaver Tom Hurley HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/11/QRCH/38 Clinical Trials Group (CTG) ICU Point Prevalence Program 2011 Clinical Research Chris Anstey Chris Anstey - 34 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/12/Austin/29 A randomized, double-clinded, active-controlled study of CB-183,315 in patiens with Clostridium difficile Associated Diarrhea 2012 Drug Trial David Sowden David Sowden Jennifer Broom Keat Choong Matthew Amodeo Andrew Henderson Johan van den Bogaerde HREC Reference: Trial Name: HREC/12/CIC/6 INTEGRATE: A randomised phase II double-blind placebo-controlled study of regorafenib in refractory advanced oesophago-gastric cancer AOGC: Protocol Number AG0212OG 2012 Drug Trial Michelle Cronk Michelle Cronk Jeremy Long Geoffrey Hawson Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/12/QGC/24 Phase II trial of panitumumab, cisplatin and gemcitabine in biliary tract cancer 2012 Drug Trial Michelle Cronk Michelle Cronk Jeremy Long Geoffrey Hawson HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/12/QGC/47 A prospective, multi-centre observational study in pateints admitted to intensive care to estimate daily sodium balance 2012 Clinical Research Victoria Campbell Victoria Campbell Peter Garrett - 35 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/12/QHC/49 Final year medical students perspectives on the importance of clinical documentation in the delivery of health care in a public health hospital 2012 Health Research Stella Rowlands Stella Rowlands Steven Coverdale HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/12/QNRC/22 Phase II randomised, double blind, multicentre study to assess the efficacy of AZD2281 in the treatment of patients with platinum containing regimens. Protocol D0810C00019 2008 Drug Trial Michelle Cronk Michelle Cronk HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/12/QPAH/267 Carers of the Active Diaylsis Trial (CO-ACTIVE) 2012 Health Research Nicholas Gray Nicholas Gray HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/12/QPAH/450 Citrate anticoagulation in continuous renal replacement therapy; more time on filter, less cost? 2012 Clinical Research David Gutierrez David Gutierrez Victoria Campbell - 36 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/12/QPCH/14 The study of heart and renal protection - extended review 2012 Clinical Research Nicholas Gray Nicholas Gray Kumar Mahadevan Euan Noble Victoria Campbell Carolyn Clark Peter Hollett HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/12/QPCH/23 Determinants and prevalence of vitamin D deficiency in HIV-infected adults living in Queensland, Australia 2012 Health Research Karen Klassen Jennifer Broom HREC Reference: Trial Name: HREC/12/QPCH/33 What complementary and alternative medicine is taken by patients with solid tumour malignancies receiving for the first time curative intent chemotherapy in a hospital day unit and what factors influence selection at that time 2012 Health Research Peter Smith Peter Smith Jeremy Long Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/12/QPCH/72 Orthogeriatric Service-Nambour General Hospital: An audit of patients aged over 60 with fractured neck of femur - comparing two models of care. 2012 Clinical Research Pathiranage Abeyratne Pathiranage Abeyratne Vanessa Harrington Gillian Puckeridge Rohan Grimley - 37 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/2006/QNRC/067 A phase 3 double blind placebo controlled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment for advanced non-small cell lung cancer 2007 Trial Clinical Michelle Cronk HREC/2006/QNRC/068 A randomised, multicentre phase IIIb, open label study of letrozole vs anastrozole in the adjuvant treatment of postmenopausal women with hormone receptor and node positive breast cancer. Face Study. CFEM345D2411 2007 Drug Trial Michelle Cronk Michelle Cronk HREC/2007/QNRC/001 A randomised, multi-centre, open-label, phase III study of adjuvant lapatinib, trastuzumab, their sequence and their combination in patients with HER2ErbB2 positive primary breast cancer. The ALTTO trial. 2008 Drug Trial Michelle Cronk Michelle Cronk HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/2007/QNRC/005 Protocol BO20289, An international multi-centre open-label 2-arm phase III trial of adjuvant bevacizumab in triple negative breast cancer. 2007 Drug Trial Michelle Cronk Michelle Cronk Geoffrey Hawson HREC Reference: Trial Name: HREC/2007/QNRC/009 A phase III randomized study of brivanib alaninate (BMS-582664) in combination with cetuximab (Erbitux) versus placebo in combination with cetuximab (Erbitux) in patients previously treated with combination chemotherapy for metastatic colorectal carcinoma. Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: Michelle Cronk Michelle Cronk - 38 - HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/2008/QNRC/006 A comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome (ACS) Sugjects with unstable angina/non-ST-elevation myocardial infarction (UA/NSTEMI) who are medically managed - The TRILOGY ACS Study 2008 Drug Trial Matthew Marrinan Matthew Marrinan HREC Reference: Trial Name: Commenced: Study Type: Local Chief Investigator: Local Co-Investigators: HREC/2008/QNRC/018 Preferences for adjuvant chemotherapy in non-small-cell lung cancer: What makes it worthwhile to patients and their doctors? 2008 Clinical Research Michelle Cronk Michelle Cronk Jeremy Long Geoffrey Hawson Trial Name: M10-791A Multicenter Study of the Efficacy and Safety of the Human Anti-TNF Monoclonal Antibody Adalimumabin Subjects with Axial Spondyloarthritis Clinical Trial Peter Nash David Nicholls Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Local Co-Investigators: M10-883A Multicenter Study of the Efficacy and Safety of the Human Anti-TNF Monoclonal Antibody Adalimumab in Subjects with Peripheral Spondyloarthritis Clinical Trial Peter Nash David Nicholls SERAPHIN OL; Study with Endothelin Receptor Antagonist in Pulmonary arterial Hypertension to Improve cliNical outcome. (Open Label) Long term single arm open-label extension study of the SERAPHIN study, to assess the safety and tolerability of ACT-064992 in patients with symptomatic pulmonary hypertension. AC-055-303 Clinical Trial Peter Nash David Nicholls David Nicholls - 39 - Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Protocol IM133004: A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging, Multi-Center Study to Evaluate the Efficacy and Safety of BMS-945429 subcutaneous Injection in Adults with Active Psoriatic Arthritis Clinical Trial Peter Nash David Nicholls BMS 101-226 :A Phase 3b, Randomized, Active Controlled Trial to Evaluate the Efficacy and Safety of Abatacept SC in Combination with Methotrexate in Inducing Clinical Remission Compared to Methotrexate Monotherapy in Adults with Very Early RA Clinical Trial Peter Nash David Nicholls A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLEBLIND,PLACEBO-CONTROLLED, PARALLEL-GROUPSTUDY TO EVALUATE THE EFFICACY AND SAFETY OF APREMILAST (CC-10004) IN THE TREATMENT OFACTIVE ANKYLOSING SPONDYLITIS Clinical Trial Peter Nash David Nicholls A PHASE 3, MULTICENTER, RANDOMIZED,DOUBLE-BLIND, PLACEBO-CONTROLLED,PARALLEL-GROUP, EFFICACY AND SAFETY STUDY OF TWO DOSES OF APREMILAST (CC-10004) IN SUBJECTS WITH ACTIVE PSORIATIC ARTHRITIS AND A QUALIFYING PSORIASIS LESION Clinical Trial Peter Nash David Nicholls A PHASE 11B, MULTI-DOSE, MULTI-CENTER, RANDOMISED, DOUBLE BLIND, PLACEBO0CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ABATACEPT VERSUS PLACEBO IN THE TREATMENT OF PSORIATIC ARTHRITIS BMS101158 Clinical Trial Peter Nash David Nicholls A PHASE 111b, MULTI-CENTER, STRATIFIED, OPEN LABEL, STUDY TO EVALUATE THE IMMUNOGENICITY, STEADY STATE TROUGH LEVEL AND SAFETY OF SUBCUTANEOUS ABATACEPT (BMS18867) IN SUBJECTS WITH RHEUMATOID ARTHRITIS ADMINISTERED WITH OR WITHOUT BACKGROUND METHOTREXATE. PROTOCOL BMS101-173 Clinical Trial Peter Nash David Nicholls - 40 - Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: A Multicenter, Randomized, Double-Blind, Placebo-controlled Trial of Golimumab, an Anti-TNFa Monoclonal Antibody, Administered Intravenously, in Subjects with Active Rheumatoid Arthritis Despite Methotrexate Therapy - CNTO148ART3001 Clinical Trial Peter Nash David Nicholls A prospective, multi centre randomised, double-blind, active comparator-controlled, parallel groups study comparing the fully monoclonal antiTNF α antibody Adalimumab given every second week with methotrexate given weekly and in combination of Adalimumab and methotrexate administered over 2 years in patients with early rheumatoid arthritis (PREMIER) (Study protocol DE 013) Clinical Trial Peter Nash David Nicholls AUX-CC-867: A Phase 3b open-label, historically-controlled study to assess the safety and efficacy of two concurrent injections of AA4500 in adult subjects with multiple Dupuytren’s contractures with palpable cords. Clinical Trial Peter Nash David Nicholls A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Evaluating the Efficacy and Safety of Baricitinib (LY3009104) in Patients with Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Tumor Necrosis Factor Inhibitors JADW Clinical Trial Peter Nash David Nicholls Trial Name: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Baricitinib (LY3009104) in Patients with Inadequate Response to Conventional Disease-Modifying Antirheumatic Drugs with Moderately to Severely Active Rheumatoid Arthritis JADX Study Type: Local Investigator: Local Co-Investigators: Clinical Trial Peter Nash David Nicholls Trial Name: Protocol H9B-MC-BCDT(a) A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Subcutaneous LY2127399 in Patients with Systemic Lupus Erythematosus (SLE) (ILLUMINATE-2) Clinical Trial Peter Nash David Nicholls Study Type: Local Investigator: Local Co-Investigators: - 41 - Study Type: Local Investigator: Local Co-Investigators: Protocol H9B-MC-BCDX Phase 3b, Multicenter,Open Label Study to Evaluate the Long Term Safety and Efficacy of Subcutaneous LY2127399 in Patients with Systemic Lupus Erythematosus (SLE) Clinical Trial Peter Nash David Nicholls Trial Name: Study Type: Local Investigator: Local Co-Investigators: BEL 116301 : Observational Study of treatment, disease activity and flare in Systemic Lupus Erythematosus(SLE) in Asia Pacific Clinical Trial Peter Nash David Nicholls Trial Name: Protocol No. IMM 10-0107 MRI and Radiological Study of rheumatoid arthritis treated with Adalimumab and non-biological agents to assess the impact of disease control on MRI manifestations and joint structure preservation. Clinical Trial Peter Nash David Nicholls Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: A randomized, double-blind, placebo-controlled, multicenter study of secukinumab to demonstrate the efficacy at 24 weeks and to assess the long term safety, tolerability and efficacy up to 2 years in patients with active psoriatic arthritis. CAIN457F2306 Clinical Trial Peter Nash David Nicholls A3921069: PHASE 3, RANDOMIZED, DOUBLE-BLIND STUDY OF THE EFFICACY AND SAFETY OF 2 DOSES OF CP-690,550 COMPARED TO METHOTREXATE IN METHOTREXATE NAIVE PATIENTS WITH RHEUMATOID ARTHRITIS Clinical Trial Peter Nash David Nicholls B3281001: A RANDOMIZED, DOUBLE-BLIND, STUDY COMPARING THE PHARMACOKINETICS AND PHARMACODYNAMICS, AND ASSESSING THE SAFETY OF PF-05280586 AND RITUXIMAB IN SUBJECTS WITH ACTIVE RHEUMATOID ARTHRITIS ON A BACKGROUND OF METHOTREXATE WHO HAVE HAD AN INADEQUATE RESPONSE TO ONE OR MORE TNF ANTAGONIST THERAPIES Clinical Trial Peter Nash David Nicholls - 42 - Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: A3921024: A Long-term, Open-label Follow-up Study of CP-690,550, a Moderately Selective Janus Kinase 3 Inhibitor, for Treatment of Rheumatoid Arthritis Clinical Trial Peter Nash David Nicholls A Phase 3 Multicenter, Randomized, Double-blind Placebo-controlled trial of Ustekinumab, a Fully Human anti-IL-12/23p40 Monoclonal Antibody, Administered Subcutaneously, in Subjects with Psoriatic Arthritis. CNTO127PSA3001 Clinical Trial Peter Nash David Nicholls WA17044 : A Randomised, Double-Blind, International Study To Evaluate The Efficacy And Safety Of Various Re-treatment Regimens Of Rituximab In Combination With Methotrexate In RA Patients With An Inadequate Response To Methotrexate Clinical Trial Peter Nash David Nicholls WA19926 –A Multi-center, randomized, double-blind, parallel group study of the safety, disease remission and prevention of structural joint damage during treatment with tocilizumab (TCZ), as a monotherapy and in combination with methotrexate (MTX), versus methotrexate in patients with early, moderate to severe rheumatoid arthritis Clinical Trial Peter Nash David Nicholls A randomized, double-blind, parallel group study of the safety and effect on clinical outcome of tocilizumab SC versus tocilizumab IV, in combination with traditional disease modifying anti-rheumatoid arthritis drugs (DMARDs), in patients with moderate to severe active rheumatoid arthritis. WA22762A Clinical Trial Peter Nash David Nicholls EFC11072 MOBILITY EXTENSION STUDY : A multi center, uncontrolled extension study evaluating efficacy and safety of SAR153191 on top of DMARDs in patients with active Rheumatoid Arthritis (RA). Clinical Trial Peter Nash David Nicholls - 43 - Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: LTS11210 MOBILITY EXTENSION STUDY : A multi center, uncontrolled extension study evaluating efficacy and safety of SAR153191 on top of DMARDs in patients with active Rheumatoid Arthritis (RA). Clinical Trial Peter Nash David Nicholls WA19924 : A Multi-center ,randomized, blinded, parallel-group study of the reduction of signs and symptoms during monotherapy treatment with tocilizumab 8mg/kg intravenously versus adalimumab 40mg subcutaneously in patients with rheumatoid arthritis. Clinical Trial Peter Nash David Nicholls CL3- 018 : A prospective multicentre, international, double-blind, placebo-controlled study for the efficacy and safety of two doses of strontium ranelate (1g and 2g per day) versus placebo administered orally for 2 years in the treatment of knee osteoarthritis. Clinical Trial Peter Nash David Nicholls RA0055 : A MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND,PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF CERTOLIZUMAB PEGOL IN COMBINATION WITH METHOTREXATE FOR INDUCING AND SUSTAINING CLINICAL RESPONSE IN THE TREATMENT OF DMARD-NAÏVE ADULTS WITH EARLY ACTIVE RHEUMATOID ARTHRITIS Clinical Trial Peter Nash David Nicholls RA0077: A MULTICENTER, SINGLE-BLIND, RANDOMIZED PARALLEL-GROUP STUDY TO ASSESS THE SHORT- AND LONG-TERM EFFICACY OF CERTOLIZUMAB PEGOL PLUS METHOTREXATE COMPARED WITH ADALIMUMAB PLUS METHOTREXATE IN SUBJECTS WITH MODERATE TO SEVERE RHEUMATOID ARTHRITIS RESPONDING INADEQUATELY TO METHOTREXATE Clinical Trial Peter Nash David Nicholls EMBODY 1 SL0009 - A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED,MULTICENTER STUDY OF THE EFFICACY AND SAFETY OF FOUR 12-WEEK TREATMENT CYCLES (48 WEEKS TOTAL) OF EPRATUZUMAB IN SYSTEMIC LUPUS ERYTHEMATOSUS SUBJECTS WITH MODERATE TO SEVERE DISEASE. Clinical Trial Peter Nash David Nicholls - 44 - Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: Trial Name: Study Type: Local Investigator: Local Co-Investigators: (EMBODY 4)PROTOCOL SL0012A Phase 3, Multicenter, Open-Label, Extension Study to Assess the Safety and Tolerablilty of Epratuzumab Treatment in Systemic Lupus Erythematosus Subjects Clinical Trial Peter Nash David Nicholls Protocol WA16855 : AN OPEN LABEL STUDY OF THE EFFICACY AND SAFETY OF RE-TREATMENTS WITH RITUXIMAB (MABTHERA/RITUXAN) IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS. Clinical Trial Peter Nash David Nicholls FX006 - ;A Double-Blind, Randomized, Parallel Group, Dose-Ranging Study Comparing FX006 to Commercially Available Triamcinolone Acetonide Injectable Suspension in Patients with Osteoarthritis of the Knee Clinical Trial Peter Nash David Nicholls CL3-12911-040: Knee joint replacement over 5 years in patients with knee osteoarthritis. A long term follow up study in patients of the CL3-12911 018 study Clinical Trial Peter Nash David Nicholls Awards and Prizes Dr Name of Recipient Impact Name of Award Awarding entity/organisation Area or Project Nicholas Gray National Rural Science Award Australia and New Zealand Society of Nephrology Peritoneal dialysis in rural Australia - 45 - Community and Professional Activities Title Name of Staff Member National/ International Name of Society Position Held Dr Dr Nicholas Gray Nicholas Gray State National Statewide Renal Clinical Network Australia and New Zealand Society of Nephrology Dr Nicholas Gray National Royal Australasian College of Physicians Dr Nicholas Gray National Dr Dr Dr Dr Rohan Grimley Rohan Grimley Peter Larsen Kelvin Larwood State National State National A/Prof A/Prof Peter Nash Peter Nash International International A/Prof Peter Nash National A/Prof Peter Nash National A/Prof Peter Nash National A/Prof Edward Weaver National Australia and New Zealand Dialysis and Transplant Registry Statewide Stroke Clinical Network Australian Stroke Units Network National Committee Statewide Cardiac Clinical Network Royal Australian and New Zealand College of Obstetricians and Gynaecologists Group for Research Psoriasis and Psoriatic Arthritis EPOSS (Outcome measures in Pulmonary Hypertension Systemic Sclerosis) Australian Rheumatology Association Scientific Advisory Committee Australian Rheumatology Association Therapeutics Committee Australia and New Zealand Bone and Mineral Society Royal Australian & New Zealand College of Obstetricians and Gynaecologists Co-Chair Member, Scientific Program and Education Committee Member, Specialist Advisory Committee in Nephrology Member, steering committee - 46 - Clinical Chair State Representative Member Member Steering Committee Member Steering Committee Member Professional Affairs Committee Member Member Member Councillor Major Partners and Linkages Project: Principal Investigator: Partners: Differential expression of microRNA in psoriasis and psoriatic arthritis A/Prof Peter Nash Kuballa A., University of the Sunshine Coast Project: Principal Investigator: Partners: Efficacy of IL6 inhibition with Tocilizumab in Asthma A/Prof Peter Nash Ferreira, M., Queensland Institute of Medical Research Project: Principal Investigator: Partners: Human and microbial gene expression in early Crohn’s disease: clues to aetiology and pathogenesis Prof Dario Sorrentino University of Woollongong CSIRO Sydney University of the Sunshine Coast - 47 - Contact Details Associate Professor Steven Coverdale Acting Director, Regional Clinical Practice Research Centre University of Queensland, Sunshine Coast Clinical School Nambour General Hospital GPO Box 547 NAMBOUR QLD 4560 Phone: 07 5470 5644 Fax: 07 5470 5720 Email: [email protected] - 48 -
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