graduate school of medicine / faculty of medicine school of public

Transcription

GRADUATE SCHOOL OF MEDICINE / FACULTY OF MEDICINE
SCHOOL OF PUBLIC HEALTH / SCHOOL OF HUMAN HEALTH SCIENCES
CONTENTS
1. HISTORY AND ORGANIZATION ...................................................................................................................................... 109
2. UNDERGRADUATE PROGRAM........................................................................................................................................ 109
3. GRADUATE PROGRAM...................................................................................................................................................... 109
4. SUB FIELD AND DEPARTMENTS ......................................................................................................................................110
MEDICINE
Biological Sciences ............................................................................................................................................................110
Anatomical Science............................................................................................................................................................110
Bioregulation......................................................................................................................................................................111
Pathology and Tumor Biology ...........................................................................................................................................112
Basic Pathology..................................................................................................................................................................112
Infectious Diseases and Immunology.................................................................................................................................113
Legal Medicine...................................................................................................................................................................115
Molecular Biology .............................................................................................................................................................115
Medical Genetics................................................................................................................................................................117
Basic Neuroscience ............................................................................................................................................................118
Internal Medicine .............................................................................................................................................................. 120
Cutaneous Life Science ..................................................................................................................................................... 125
Developmental Medicine .................................................................................................................................................. 125
Radiology and Nuclear Medicine...................................................................................................................................... 126
Clinical Pathology ............................................................................................................................................................. 128
Surgery .............................................................................................................................................................................. 128
Clinical Sciences Surgical for Stresses.............................................................................................................................. 129
Surgery for Visceral Organs .............................................................................................................................................. 130
Surgery for Sensory and Motor Systems ........................................................................................................................... 133
Clinical Neuroscience ....................................................................................................................................................... 137
SCHOOL OF PUBLIC HEALTH
Epidemiology and Biostatistics ......................................................................................................................................... 139
Health Administration ....................................................................................................................................................... 140
Health Determinants.......................................................................................................................................................... 142
International Health........................................................................................................................................................... 143
SCHOOL OF HUMAN HEALTH SCIENCES ..................................................................................................................... 143
CONTRIBUTED CHAIRS ................................................................................................................................................... 146
CAREER-PATH PROMOTION UNIT FOR YOUNG LIFE SCIENTISTS ......................................................................... 148
5. RESEARCH FACILITIES..................................................................................................................................................... 148
Institute of Laboratory Animals......................................................................................................................................... 148
Congenital Anomaly Research Center............................................................................................................................... 148
Center for Anatomical Studies........................................................................................................................................... 149
Center for Genomic Medicine ........................................................................................................................................... 149
Center for Medical Education ........................................................................................................................................... 150
Human Brain Research Center .......................................................................................................................................... 150
KUMBL (Kyoto University Medical Science and Business Liaison Organization).......................................................... 151
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FGRADUATE SCHOOL OF MEDICINE
FACULTY OF MEDICINE
SCHOOL OF HUMAN HEALTH SCIENCES
Dean: MITSUYAMA, Masao, M.D., D.Med.Sc.
Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, JAPAN
Tel. +81-75-753-4300
Fax. +81-75-753-4348
http://www.med.kyoto-u.ac.jp/E/index.html
1. HISTORY AND ORGANIZATION
This school/faculty stems from the College of Medicine
established in Kyoto in July, 1899. Twenty years later, in 1919,
it was renamed the Faculty of Medicine. The Department of
Pharmacy was first established within this Faculty in 1939; in
1960 becoming the independent Faculty of Pharmaceutical
Science. Recently the Faculty of Medicine has been reorganized so as to emphasize the education and research in the
graduate program, which covers seven major fields of medical
sciences: Physiology, Pathology, Social Medicine, Internal
Medicine, Surgery, Molecular Medicine and Neuroscience.
All faculty members of the graduate program are now jointly
appointed as the teaching staff for the undergraduate courses.
At present, the departments in the Graduate School of
Medicine are grouped into 20 subfields, a few of which consists of both basic and clinical departments. Education in the
graduate school is strengthened by the participation of active
researchers from six attached research facilities and several
other affiliated institutions, which include the Institute for Virus Research, Institute for Frontier Medical Sciences, Institute
for Chemical Research, Research Reactor Institute, and Radiation Biology Center. The majority of the core departments
studying basic medical sciences are located on campus,
whereas those studying clinical medical sciences are housed
in the adjacent University Hospital.
Final decisions on matters concerning the undergraduate
program, including the selection and appointment of its staff
members, are made in the Faculty Meeting which is chaired
by the Dean. The decisions on the postgraduate program are
made in the separate Board Meeting which is also chaired by
the Dean.
The School of Public Health was established in April 2000.
This is the first of this kind in our country specifically designed to prepare competent professionals in public health.
The primary focus is to enhance human health through organized community efforts based on basic, clinical, and social
sciences. In addition, reflecting the recent trend in North
America and Europe, clinicians are also expected to study in
this program to bridge the gap between individual approach in
clinical medicine and population approach in public health. It
has increasingly become obvious for professionals in medicine to have the stance to view "people in the context of society". This School has currently 4 fields with 12 departments.
The Faculty of Medicine, School of Health Sciences was
established in October 2003, evolving from the former College of Medical Technology which had been founded in 1975.
The aim of the school is to advance health care science associated with frontier medicine and to meet the rapidly increasing demands in various fields of medical science and technology, in order to ensure high quality, healthy life for people
in the 21st century.
The School of Health Sciences consists of the following four
departments :
Department of Nursing
Department of Laboratory Science
Department of Physical Therapy
Department of Occupational Therapy
A total 143 first year students were accepted on the 7th of
April 2004: 70 in Nursing, 37 in Laboratory Science, 18 in
Physical Therapy, and 18 in Occupational Therapy.
The School of Human Health Sciences was authorized in December 2006 and established in April 2007. This school consists of the three courses, such as Nursing, Laboratory Science,
and Rehabilitation. A total 39 first year students were accepted on the April 2007:17 in Nursing, 7 in Laboratory Science, and 15 in Rehabilitation.
We will explore through the studies of medical care, health
care, and welfare from a holistic perspective, based on human
cultural, and social science as well as natural science including medicine.
2. UNDERGRADUATE PROGRAM
The Faculty of Medicine, Department of Medical Science
accepts 100 students each year, providing two years of premedical courses followed by four years of clinical medical
courses. Since 1970, the unique "Level-System" curriculums
have been in use to help students study and understand effectively the bulk of basic medical knowledge before starting
their clinical training: In the initial Level courses, students
study the molecular and cellular basis of human development
and anatomy, organ functions, and human diseases. In the
next System courses, they study the functions and malfunctions of the organ systems. Students are expected to actively
participate in these lectures and laboratory courses and undertake for themselves whatever studies are necessary in order
to develop their understanding of the topics presented. During
the fourth year, they have the opportunity to visit laboratories
on- and off- campus for several weeks to gain experience of
research activities in their field of choice.
3. GRADUATE PROGRAM
The Graduate School of Medicine accepts approximately
140 students wishing to receive the Doctor of Medical Science (D.Med.Sc.) degree. To be accepted in this program, it is
required for the applicants to already hold an M.D. or Master's degree and to pass the entrance examination. It usually
takes four years for students to complete the program, and
during or after the term they should publish original research
work in widely-circulated, international journals to become
candidates for the doctorate degree. Both the undergraduate
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and graduate programs accept overseas students if they fulfill
the requirements for admission and successfully pass the entrance examination. Research students and, research fellows
in graduate courses may be accepted upon approval by the
Board of the Graduate School of Medicine. Postgraduate Research Fellows, Visiting Research Scholars, Guest Scholars,
and Visiting Professors may also participate in the research
and educational activities. Most staff members speak English,
and some are fluent in other languages as well.
The School of Public Health accepts 30 candidates for the
professional degree course of Master of Public Health
(M.P.H.) and 12 candidates for Doctor of Public Health
(Dr.P.H.). It usually takes 2 years and 3 years for M.P.H. and
Dr.P.H. respectively. The M.P.H. program primarily consists of
course work, requiring at least 30 credit units and presentation
of individual research project. The Dr.P.H. course, on the
other hand, requires the publication of at least one research
work in a peer-reviewed, international journal of high volume
circulation. The following groups of applicants will be considered for these degree programs. 1. Graduates of professional programs such as medicine, dentistry, veterinary medicine, pharmacology, and nursing. 2. Graduates of bachelor's
degree programs in such fields as law, engineering and other
natural sciences.
4. SUB FIELD AND DEPARTMENTS
MEDICINE
BIOLOGICAL SCIENCES
Research in Biological Sciences is concerned with the
mechanisms underlying the information processing in biological systems. The research activities are mainly focused
on the computation in neural systems as well as the functional
maturation in neuronal architectures. To achieve in-depth
understanding of complex biological systems like neural systems, the research and education in this subfield place emphasis on experimental and theoretical approaches and on molecular and systems view of biological function.
DEPARTMENT OF BIOLOGICAL SCIENCES
The Department of Biological Sciences was originally established in 1981 as the Department of Allergy, Institute for
Immunology, and reorganized into the present Department in
1993. Dr. Shigetada Nakanishi, appointed as the first Professor in 1981, made a great contribution in neuroscience: he
developed a series of innovative methods to dissect neuronal
mechanisms at molecular level and elucidated their physiological roles at systems level. In 2006, Dr. Dai Watanabe of
Osaka Bioscience Institute succeeded Dr. Nakanishi after his
retirement. Dr. Watanabe was also appointed as Professor of
Graduate School of Biostudies.
Outline of Teaching Activities:
The Department is responsible for instruction in molecular
biology and systems neuroscience for undergraduate and
graduate students.
Outline of Research Activities:
The current research activities are mainly focused on
neuronal mechanisms underlying sensory perception, motor
control and neural coding. To address these fundamental
questions in brain function, the multi-disciplinary approaches
are conducted by combining theoretical analyses with a wide
range of experimental techniques.
Professor:
WATANABE, Dai, M.D., D.Med.Sc. (Kyoto Univ.), Molecular
and systems biology of neural computation and development;
Associate Professor:
NAKAJIMA, Yoshiaki, M.D., D.Med.Sc. (Kyoto Univ.), Molecular biology of synaptic regulation;
ANATOMICAL SCIENCE
The Department of Anatomy was opened when the College of Medicine was established in Kyoto University in 1899.
Until April, 1990 the Department consisted of three
sub-departments.
Dr. Buntaro Adachi, the first Professor in the Department,
carried out internationally regarded studies on the arterial and
venous systems of the Japanese, and was honored with the
Onshi (Imperial Academy) Prize by the Japan Academy in
1930. Later, three other Professors were honored with prestigious Academy Prizes by the Japan Academy for their scientific contributions: Dr. Ko Hirasawa for neuroanatomical
studies in 1951; Dr. Takusaburo Kihara for studies on the extravascular lymph system in 1958; and Dr. Hideo Nishimura
for studies on congenital anomalies in human and mammalian
embryos in 1978.
In addition to scientific contributions, the Anatomy Professors have been very active in administration. Among the
thirteen Professors, six of them served as Dean of the Faculty
of Medicine and two became Presidents of Kyoto University,
Drs. Ko Hirasawa and Michio Okamoto.
As of April, 1990, the First sub-department, which had
played a major role in the teaching and research of neuroanatomy, was reconstituted as the Department of Brain Morphology in the Graduate Curriculum. Consequently, the Department of Anatomy was reduced to two subdepartments,
with the former Third sub-department being renamed as the
First sub-department. With the subsequent reconstitution
from the Faculty of Medicine to the Graduate School of
Medicine, the first and second subdepartments have been renamed as the Department of Anatomy and Developmental Biology, and Department of Anatomy and Neurobiology, respectively.
The present staff of two Departments includes 6 faculty
members, 2 technicians, and 2 secretaries. There are at present
5 graduate students, 4 research students, and 3 research fellows. The staff is active in a broad range of research fields
as listed below. National and international collaborative researches are frequently conducted, and a number of overseas
scholars visit the Department for varying periods of time.
DEPARTMENT OF ANATOMY AND
DEVELOPMENTAL BIOLOGY
Tel. +81-75-753-4341
Fax. +81-75-751-7529
The Department of Anatomy and Developmental Biology
(formerly the Third Division of the Department of Anatomy)
was a section of the former Department of Anatomy which
Medicine
was opened in Kyoto University in 1899. Human and comparative embryology was one of the main areas of research in
the former Department of Anatomy. In April 1996, the former
Third Division of the Department of Anatomy was renamed
the Department of Anatomy and Developmental Biology.
This department is responsible for teaching developmental
biology and gross anatomy for graduate and undergraduate
students. Research fields in the department include: 1.
Mechanisms of morphogenesis; 2. Human and comparative
embryology and developmental biology; 3. Molecular basis of
mammalian development; 4. Theoretical analysis of morphogenesis; and 5. Reproductive and developmental toxicology.
Research is carried out by means of diverse laboratory technologies including morphological techniques, cell and molecular biological techniques, in vitro cultures, and theoretical
biological analyses with computer simulations.
The study of developmental mechanisms is currently
among the most exciting research topics, and the research interest of the staff members in this department is focused on
mammalian development and reproduction. They publish research papers actively, and several international and domestic
collaborative research projects are in progress. Overseas
scholars visit the department periodically.
Professor:
SHIOTA, Kohei, M.D., D.Med.Sc. (Kyoto Univ.), 1. Human
and comparative embryology; 2. Mechanisms of morphogenesis; 3. In vivo and in vitro experimental embryology; 4.
Reproductive and developmental toxicology;
MIURA, Takashi, M.D.,D.Med.Sc. (Kyoto Univ.), 1. Mechanisms of morphogenesis; 2. Theoretical biology of development;
Assistant Professor:
OKANO, Junko, M.D.,D.Med.Sc. (Kyoto Univ.), 1. Normal
and abnormal development of the palate and related craniofacial structures; 2. Molecular mechanism of skin development;
DEPARTMENT OF ANATOMY AND
NEUROBIOLOGY
This Department is responsible for instruction in histology
and cell biology for undergraduate and graduate students.
The major fields in research are as follows:
1. Genetic and epigenetic regulation of the germ cell lineage.
2. Reconstruction of the germ cell lineage in vitro.
3. Genetic and epigenetic regulation of cell fate specification.
4. Culture and manipulation of tissue-specific stem cells.
BIOREGULATION
This subfield is dedicated to the study of mechanisms underlying the regulation of biological functions at the molecular, cellular and organ levels. The Department of Physiology
and Biophysics and the Department of Pharmacology constitute this subfield of study, and the primary foci of ongoing
research are on the physiological and pharmacological regulation of cardio-vascular system, and molecular mechanisms of
cancer formation and treatment using mouse models.
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DEPARTMENT OF PHYSIOLOGY AND
BIOPHYSICS
http://www.card.med.kyoto-u.ac.jp
The primary focus of research has been on the cellular and
molecular physiology of the cardiac muscle. The ion channels,
transporters, membrane receptors, the excitation-contraction
coupling, energy metabolism, and the intracellular ion homeostasis are studied in relation to the cardiac membrane excitation, pacemaker activity, signal transduction, development
of the cardiac cells, and regulation of muscle contraction. We
are developing a comprehensive cardiac cell model (Kyoto
Model) in silico to understand the regulation of the cardiac
cell function.
The Department is responsible for undergraduate and
graduate education of physiology in general.
MITSUIE, Tamotsu, D.Med.Sc. (Univ. of Tokyo), Neural
regulation of heart
Assistant Professors:
TAKEUCHI, Ayako, D.Pharm.Sc. (Kyoto Univ.), 1. Cardiac
cell physiology; 2. Transporters and modeling
DEPARTMENT OF PHARMACOLOGY
The Department of Pharmacology was opened in 1899,
and Dr. Kurata Morishima was appointed the first Professor
(1900-1928). He established the basis of pharmacology in
Japan by introducing modern pharmacodynamic methods into
drug research. The next Professor of the first subdepartment,
Dr. Kikuo Ogiu (1932-1958), applied electrophysiological
methods in pharmacological studies of drugs acting on the
autonomic and central nervous systems, producing important
new findings. Professor Kiro Shimamoto (1958-1968) further elucidated the mechanism of these drugs by applying
histological and biochemical methods to pharmacological
studies. He also played a pioneering role in the field of toxicology. Professor Motohatsu Fujiwara (1969-1990) discovered the goniopora toxin, a cardiotonic peptide from sea choral and identified its action mechanism. He also found endothelium-dependent contraction of cerebral arteries. Professor
Tomoh Masaki directed the department in the period
1991-1998, and led the field of endothelin research.
In 1999, Professor Makoto Mark Taketo assumed the
professorship as a joint appointment with the University of
Tokyo (Laboratory of Biomedical Genetics, Graduate School
of Pharmaceutical Sciences). He officially moved to the Department as of October 1, 2000. He is running a new program
in the field of genetic pharmacology and tumor biology using
knockout mouse models for cancer (e.g., colon cancer and
hepatocellular carcinoma). The Department now includes 4
faculty members, 2 technicians, 3 postdocs, 1 research fellow,
and 2 graduate students.
The Department is responsible for education of the medical students in pharmacokinetics, pharmacodynamics, and the
pharmacological basis of therapeutics in the autonomic nervous, cardiovascular, gastrointestinal and neuroendocrine systems.
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The major fields of research are construction and analysis
of genetically modified mouse models for human diseases,
especially cancers of the digestive system such as colon and
liver.
Professor:
TAKETO, Makoto Mark, M.D., D.Med.Sc. (Kyoto Univ.),
Construction and analysis of mouse models of human diseases
such as those for colon cancer and autonomic nervous dysfunction;
AOKI, Masahiro, M.D., D.Med.Sc (Osaka Univ.), Molecular
analysis of deregulated signal transduction pathways in cancer;
KITAMURA, Takanori, D.V.M., Ph.D. (Hokkaido Univ.), 1.
Construction and analysis of mouse models of human diseases; 2. Molecular embryology of the mouse;
SONOSHITA, Masahiro, Ph.D. (Hokkaido Univ.), Construction
and analysis of mouse models of human diseases;
2. Neural development and synapse formation
3. Molecular mechanism of aging
4. Gene manipulation in mice
5. Mechanism of carcinogenesis based on the studies of oncogene and tumor suppressor genes
6. Pathological studies on autopsy and biopsy cases
Professor:
NABESHIMA, Yo-ichi, M.D., D.Med.Sc. (Niigata Univ.), 1.
Molecular mechanism of development; 2. Regulation of neuronal network formation; 3. Regulation of aging; 4. Gene
manipulation in mice
TAKAHASHI, Rei, M.D., D.Med.Sc. (Kobe Univ.), 1. Functional aspects of human tumor suppressor genes; 2. Molecular and cytogenetic studies on oncogene activation in human
and experimental malignancies; 3. Molecular pathology in
general
IMURA, Akihiro, M.D., Med.Sc. (Kyoto Univ.), Mineral
Homeostasis and Endocrine pathology
TANAKA, Tomohiro, M.D., D.Med.Sc. (Kyoto Univ.), Pathologic basis of obesity, diabetes and dyslipidemia
ITO, Shinji, D.Med.Sc. (Kyoto Univ.), Molecular Biology and
Metabolism
PATHOLOGY AND TUMOR BIOLOGY
DEPARTMENT OF PATHOLOGY AND
TUMOR BIOLOGY
BASIC PATHOLOGY
The department was originally established in 1907 by Professor Takeshi Hayami seven Years after the opening of the
Department of Pathology by Professor Akira Fujinami. Professor Hayami, 1907 to 1922, contributed to the Pathology of
hepatic cirrhosis and developed pioneering methods for tissue
culture. Professor Kenji Kiyono, 1923 to 1938, discovered,
together with Professor Aschoff of Freiburg University, tissue
histiocytes by vital staining and established the concept of the
"reticuloendothelial system (RES)" for which he was awarded
the Prize of the Japan Academy of Science. Professor Kiyono
is also known for his archeological studies on the origin of the
Japanese nation. Professor Sigeki Mori, 1940 to 1956, extensively studied the endocrine backgrounds of cancer. Professor
Kozo Okamoto, 1956 to 1972, developed various histochemical methods for metals such as copper and zinc. He applied them to the studies of experimental diabetes and proposed the "zinc theory of diabetes mellitus". Later, his studies
were linked to the establishment of "spontaneous hypertensive
rats (SHR)" which were used as an experimental model of
human hypertension, for which he was awarded the Prize of
the Japan Academy of Science. Professor Yoshihiro Hamashima, from 1974 to 1987, introduced immunohis-tochemistry
into Japan and applied the methods to immunopathology.
Professor Taketoshi Sugiyama, 1989 to 1995, carried out extensive molecular cytogenetic-studies on 7, 12-dimethylbenz
(a) anthracene-induced rat leukemia. He was a pioneer in molecular pathology and reviewed the progress in his book, Molecular Pathology. In 1998, Professor Yo-ichi Nabeshima
started the present laboratory. The standing point largely
changed from human pathology to molecular biology of diseases based on modern gene technology and gene manipulation in mice.
DEPARTMENT OF PATHOLOGY AND
BIOLOGY OF DISEASES
Outline of Teaching Activities in Postgraduate Course:
1. Regulation of development and cell differentiation
The Department of Pathology and Biology of Diseases
originates in the First Department of Pathology founded in
1900 by Dr. Akira Fujinami, 1900-1930. Dr. Fujinami's discovery of chicken sarcomas which is transmissible by filterable agents was one of the earliest demonstrations of an oncogenic retrovirus. He has also made a great contribution to
public health by identifying a river shell (Miyairi-gai) as an
intermediate host of Schistosoma japonicum.
The aim of the present department is to understand the biological and genetic bases of diseases, particularly of cancer,
and to train graduate students with the most up-to-date techniques. Therefore, most studies in this department are carried
out using multi-disciplinary approaches including molecular
and cellular biology, genetics, bio-imaging, computer sciences, and histological pathology.
The Department of Pathology and Biology of Diseases is
responsible for undergraduate- and graduate-level education
in collaboration with Department of Tumor Biology and Pathology as well as Laboratory of Anatomic Pathology in the
University Hospital. The pathology course for medical students and graduate students is planned as a systematic education of pathology. It consists of lectures, the analysis of autopsy cases, and examination of pathologic materials from
autopsy and surgical specimens.
The course is divided into two parts; Basic Pathology (B4),
which gives instruction in the mechanism of tissue injury and
repair, circulatory disturbances, inflammation, and oncology:
and Systemic Pathology (B5), which gives instruction in the
macroscopic and microscopic pathologic changes in each organ. Extensive laboratory training in histopathology is given
Medicine
for medical students in the 3rd year.
For the graduate students, 4 years' research training is
provided in the research area of molecular and cellular biology, bio-imaging, and molecular pathology. By submitting a
thesis (normally one or two full papers published as the first
author in a peer-reviewed international scientific journal), the
degree of doctor of medical science (D.Med.Sc.) will be
awarded to a successful candidate. For research students, 5
years' training is required.
1. Molecular mechanism of oncogenesis.
2. Development of GFP-based biosensors for the activities of
oncogene products.
3. In vivo, ex vivo, and in vitro bio-imaging of growth signal
transduction cascades.
Detailed description of research activities is given in the
Department's Scientific Report published biannually which
is available on request
(http://www.path1.med.kyoto-u.ac.jp).
Professor:
MATSUDA, Michiyuki, M.D., D.Med.Sc. (Tokyo Univ.), 1.
Mechanism of cellular transformation by oncogene products;
2. Development of fluorescence probes for the activities of
oncogene products
Senior Lecturer:
KIYOKAWA, Etsuko, M.D., D.Med.Sc. (Hamamatsu Univ.
Sch. Med.), 1. FRET imaging of oncogenesis and morphogenesis; 2. Analysis of signaling pathways related to Ras G
protein super family
DEPARTMENT OF DIAGNOSTIC PATHOLOGY
This newly established pathology department was founded
in 1997. The department has been established as one of the
two research specialties in the Department of Basic Pathology,
and replaces the Department of Developmental Pathology.
This is a department of diagnostic pathology, and the major
aims of this department are to understand the morphological
basis of diseases, to engage in pathology education, to engage
in practical diagnostic activities in surgical and autopsy pathology in the University Hospital, and to train diagnostic pathologists with a sound modern biomedical background. The
Professor of this department also directs the Laboratory of
Anatomic Pathology in the University Hospital.
The department is responsible for education of anatomic
pathology in undergraduate and graduate school students, and
hospital residents. The education includes: 1. Special Pathology (B5) for 3rd year undergraduate students, giving instruction in macroscopic and microscopic pathology through practical histopathologic exercises; 2. Laboratory medicine (I4)
for 4th and 5th year undergraduate students, giving instruction
in clinical pathology, laboratory methodology, and laboratory
diagnostics through lectures and small group exercises; and 3.
Clinico-pathologic conferences (CPC) for medical students,
hospital residents and clinicians. Education is carried out in
partial collaboration with the Departments of Pathology and
Biology of Diseases, and Tumor Biology and Pathology in the
Graduate School of Medicine, and Laboratory of Anatomic
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Pathology and Central Clinical Laboratories in the University
Hospital.
The Department is concerned with clinicopathologic studies on hepatic transplant pathology, the pathology of malignant lymphomas, the pathology of bone tumors, pulmonary
pathology, gastrointestinal pathology, gynecologic pathology,
skin pathology and the pathology of breast tumors.
Professor and Director:
MANABE, Toshiaki, M.D., FCAP., 1.Surgical pathology; 2.
Pulmonary pathology; 3. Dermatopathology
Associate Professor
MIKAMI, Yoshiki, M.D., D.Med.Sc. (Tohoku Univ.), 1. Surgical pathology; 2. Gyecologic pathology; 3. Urologic pathology; 4. Diagnostic Cytopathology
Senior Lecturer:
NAKASHIMA, Yasuaki, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Surgical pathology; 2. Bone tumors
YOSHIZAWA, Akihiko, M.D., (Kyoto Univ.), 1. Surgical pathology
MIYAGAWA-HAYASHINO, Aya, M.D., D.Med.Sc. (Kyoto
Univ.), 1. Liver Transplantation pathology; 2. Pulmonary pathology; 3. Dermatopathology
INFECTIOUS DISEASES AND IMMUNOLOGY
The Research Section of Infectious Diseases and Immunology consists of two departments: The Department of Microbiology and the Department of Immunology and Cell Biology.
The Department of Microbiology is responsible for study
on the molecular mechanism of some bacterial and viral infections and host responses. The Department of Immunology
and Cell Biology is responsible for study on the basic mechanism of immune response and application to clinical immunology.
Both Departments are responsible for teaching both undergraduate and graduate students in Medical School.
DEPARTMENT OF MICROBIOLOGY
The Department of Microbiology originates from the Department of Hygiene established in 1899. In 1916, the microbiology section became an independent Department under
the direction of Professor Matsushita, who carried out studies
on pathogenic bacteria and complements. The second Professor, Dr. Kiyono, conducted significant and pioneering studies
in the field of general microbiology and immunology until
1928 on the reticuloendothelial system and the development
of vital staining. Subsequently the department was directed by
Professor Kimura until 1956. Dr. Kimura was the first to introduce the technique of tissue culture to the country in the
early 1930's, and extensive studies on its application contributed greatly to the development of microbiology and immunology. The first electron microscope designed and assembled
in Japan was set up in this Department by Dr. Kimura and his
associate, Dr. Higashi. The discovery and study of new strains
of vitamin B-decomposing bacteria was another line of research conducted by Dr. Kimura and granted the award of the
Japan Academy in 1959. He also contributed to the establishment of the Institute of Virus Research. Professor Tabei
('57-'69) focused the research activities mainly on host re-
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sponse to infectious agents along with the studies on Japanese
encephalitis virus and leukemia virus. As the fifth Professor,
Dr. Ito was appointed in 1973. He was the first to identify the
transmission of infection by DNA in 1960 and founded the
study of human oncogenic viruses in Japan, including papillomavirus, Epstein-Barr virus (EBV), and human T cell leukemia virus I (HTLV-I). Among the leading studies conducted
by Dr. Ito, the search for environmental cofactors in
EBV-related human malignancy has been widely respected
amongst oncologists for its pioneering features. Professor
Takeda was the sixth director of the Department until he
moved to The Research Institute of International Medical
Center as the President in 1995. During Dr. Takeda's short
appointment for 5 years, the department elucidated the molecular mechanisms of enteric infection caused by E. coli, Vibrios and related bacteria from the viewpoint of structure and
function of bacterial toxin. The present Professor, Dr.
Mitsuyama (formerly Professor of Bacteriology in Niigata
University School of Medicine) was appointed in April 1998.
Now the research in this department is focused mainly on the
molecular mechanism of virulence expression by intracellular
parasitic bacteria including Listeria monocytogenes and Mycobacterium tuberculosis, and on the immune response of the
host to virulence factors of these bacteria. The 35th Saburo
Kojima Memorial Award has been awarded to Prof.
Mitsuyama in 1999 to his recent pioneering works on the role
of bacterial protein toxin for the host immune response.
The Department is responsible for teaching the whole field
of microbiology including bacteriology, mycology, virology
(B2a, b) and parasitology (B3) to undergraduate medical students. Lectures on parasitology are given mainly by specialists from other institutions nationwide. For the graduate students, a four-year research training in microbiology and infection immunity is provided by the department staffs.
1. Molecular mechanisms of escape and survival of intracellular bacteria inside macrophages.
2. Host defense mechanisms against bacterial infection with
special reference to macrophage activation and the
development of protective Th1 cells.
3. Structure and function of bacterial protein toxin.
4. Molecular mechanism of apoptosis and necrosis in infected
cells.
Professor:
MITSUYAMA, Masao, M.D., D.Med.Sc. (Kyushu Univ.), Host
defense against bacterial infections and the molecular
mechanism of intracellular parasitism;
KAWAMURA, Ikuo, D.Med.Sc. (Kyushu Univ.), Molecular
mechanism of intracellular parasitism and host immune response, structure and function of pore-forming toxins;
NOMURA, Takamasa, D.Med.Sc. (Kyoto Univ.), Virulence-associated gene of Listeria monocytogenes, Immune
response in bacterial infection;
TSUCHIYA, Kosuke, D.Med.Sc. (Kyoto Univ.), Virulence-associated gene of Listeria monocytogenes, Immune
response in bacterial infection;
DEPARTMENT OF IMMUNOLOGY AND
CELL BIOLOGY
The Department of Immunology and Cell Biology was
originally established as a Department of Immunobiology in
the Institute for Immunology in the Faculty of Medicine in
1973. In 1974, Dr. Kimishige Ishizaka, who discovered IgE
and was honored with an Order of Cultural Merit by the
Japanese Government, was appointed as the first Professor of
the Department. After his resignation in 1979, Dr. Tasuku
Honjo, another world wide leader in the immunogenetics,
succeeded him during 1982-1983. In 1992, Dr. Nagahiro
Minato, who made a great contribution in the early stage of
NK cell discovery, was appointed as the third Professor in the
Department. As the Faculty of Medicine has been reorganized as the Graduate School of Medicine in 1994, the Institute
for Immunology was dissolved and the Department of Immunobiology was reorganized into the present Department of
Immunology and Cell Biology in the Graduate School of
Medicine.
Since the reorganization, this section has continued to be
responsible for the education of basic immunology for both
undergraduate and graduate students, and the research fields
have been significantly expanded into many related fields in
the cell biology and medicine.
The Department is responsible for instruction in immunology for both undergraduate and graduate students.
The current research activities are focused on the understanding of the molecular and cellular mechanisms of lymphocyte development, proliferation, and antigen recognition
in the immune system. Based on these fundamental molecular analyses and by applying all possible modern biological
techniques, a diverse range of immunological phenomena as
well as diseases are studied, including tumor immunity, infection immunity, transplantation immunity as well as autoimmunity, aiming at the ultimate ideal manipulations for the intractable human diseases related to the immunology.
Professor:
MINATO, Nagahiro, M.D., D.Med.Sc. (Kyoto Univ.), Mechanisms of the development and functions of the immune system
and their involvement in health and diseases;
HAMAZAKI, Yoko, D.Med.Sc. (Kyoto Univ.), Organizing
mechanisms of tissue architecture in lymphoid organs and its
functional importance in immune homeostasis;
AGATA, Yasutoshi, M.D., D.Med.Sc. (Kyoto Univ.), Mechanisms of antigen receptor gene rearrangements and the development of lymphocytes and their functional involvement in
diseases;
Medicine
LEGAL MEDICINE
DEPARTMENT OF FORENSIC MEDICINE AND MOLECULAR PATHOLOGY
The department of legal medicine was founded in 1899 by
Professor Yanamatsu Okamoto, one of Japan’s pioneers in the
field of legal medicine, under the solemn premise of being
Japan’s leading and most dedicated academic institution to the
forensic sciences. Mataichiro Kominami, who succeeded
Professor Okamoto, made the invaluable contribution of
enlightening the general public as to the importance of legal
medicine, not only from the practical perspective of forensic
autopsies but as an academic discipline, as well. The 3rd, 4th,
5th and 6th generations headed by Professors Chusetsu Endo,
Takeji Kuroiwa, Masao Ueda and Yuko Fukui, actively carried out the missions of the Department in accordance with
the strictest of standards and noblest of traditions since the
Department’s inception. From an individual context, Professor
Ueda conducted pioneering work on acute alcohol intoxication and was also one of the co-founders of the Japanese Association of Medical Law. Dr. Fukui, the 6th professor, conducted some of the first research on cocaine as well as ethanol.
In 2002, Dr. Keiji Tamaki was appointed as the 7th Professor.
Dr. Tamaki's major field of study is human DNA polymorphism in tandem repeat sequences such as minisatellites and
the focus of his interests lie in elucidating the mechanisms of
instability in the genome. The department also performs forensic autopsies upon request from local law enforcement. In
2008, the department underwent restructuring and was renamed the Department of Forensic Medicine and Molecular
Pathology in order to reflect its growing investigative role in
the field of molecular pathology.
Teaching activities cover the following areas: 1. Determination of death including brain death and post-mortem
changes; 2.Sudden and unexpected death from natural causes;
3.Injuries; 4.Asphyxias; 5.Toxicology; 6.Drug abuse; 7.Blood
groups; 8.Medical law and analyses of malpractice cases; 9.
DNA polymorphism along with its forensic application.
Research is currently in progress in the following areas: 1.
Minisatellite instability in the human genome and phylogenic
studies; 2. Forensic application of DNA polymorphisms;
3. Virus-host interaction in mouse lymphomagenesis; 4. Arteriopathy in chronic allograft rejection in liver transplantation;
5. Forensic and criminological studies on autopsy cases.
Professor:
TAMAKI, Keiji, M.D., D.Med.Sc. (Nagoya Univ.), DNA
polymorphism and its forensic application;
TSURUYAMA, Tatsuaki, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Surgical pathology; 2. Virology;
OKUNO, Tomoko, M.D., 1. Surgical pathology; 2. Transplantation pathology;
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MOLECULAR BIOLOGY
The three departments in this subfield are devoted to the
identification and characterization of various genes and their
products whose malfunction leads to important diseases such
as cancer, cardiovascular diseases, high blood pressure and
immune deficiency. Staff members of these departments are
also responsible for the Level courses of Biochemistry, Molecular Biology and Genetics for undergraduate students.
DEPARTMENT OF MEDICAL CHEMISTRY
AND MOLECULAR BIOLOGY
Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, JAPAN
TEL: +81-75-753-9445
FAX: +81-75-753-9446
http://www2.mfour.med.kyoto-u.ac.jp/~nagata/
The Department of Medical Chemistry was founded in
1899, and Dr. Torasaburo Araki was appointed as the first
Professor and Chairman. In 1915, Dr. Araki became the
President of Kyoto University and in 1919 Dr. Kanae Maeda
succeeded him in Professorship. In 1942, Dr. Senji Uchino
was appointed as the third Professor. In 1958, Dr. Osamu
Hayaishi, Chief, Section of Toxicology, National Institutes of
Health, U.S., was appointed as the fourth Professor and
Chairman of the Department. In 1961, the Department was
divided into two sub-departments. Dr. Hayaishi was the
Chairman of the Department and the Professor of the 1st
sub-departments, and Dr. Shosaku Numa was appointed as the
first Professor of the 2nd sub-departments in 1968. In 1984,
Dr. Tasuku Honjo, Professor of the Department of Genetics,
Osaka University Medical School, succeeded Dr. Hayaishi
after his retirement. In 2007, Dr. Shigekazu Nagata, Professor
of the Integrated Biology Laboratory, Graduate School of
Frontier Biology, Osaka University, succeeded Dr. Honjo.
During the past fivedecades, this Department has become one
of the leading centers of biochemical and molecular biological
research in the world, and a large number of visiting scientists
from abroad have come to exchange information and carry
out collaborative experiments. Members in the Department
are laureates of many honors and awards. For example,
“Order of Culture” to Dr. Hayaishi, Recognition as “a Person
of Cultural Merits” to Drs. Hayaishi, Honjo, and Nagata, and
Emil Boehring Prize and Koch Prize from Germany to Dr.
Nagata.
Teaching Activities:
The department is responsible for instruction of biochemistry and molecular biology for undergraduate and graduate
students.
Research Activities:
In the department of Medical Chemistry, We are currently
studying the molecular mechanism and physiological role of
apoptosis. In 1991, we identified Fas, a protein of the tumor
necrosis factor (TNF) receptor family, and showed that Fas
can transduce an apoptotic signal into cells. Subsequently, we
in collaboration with Dr. Goldstein in Marseille identified in a
cytotoxic T cell clone a cytokine (Fas ligand) that can kill the
Fas-bearing cells. We then found that two mouse mutations,
lpr (lymphoproliferation) and gld (generalized lymphoproliferative disease) that cause lymphadenopathy and
splenomegaly, and accelerate autoimmune diseases, are mutations of Fas and Fas ligand, respectively. Fas ligand is ex-
116
pressed on the cell surface of activated cytotoxic T cells
(CTL) or natural killer (NK) cells, and works as one of the
effector molecules for their cytotoxic activity. Since the administration of agonistic anti-Fas antibody or Fas ligand rapidly killed the mice by causing acute hepatitis, we postulated
that the exaggeration of Fas ligand-induced apoptosis is responsible for the CTL-induced tissue destruction.
We studied the signal transduction for the Fas-induced
apoptosis, and found that a cascade of proteases (caspases) is
activated in this process. We then identified an enzyme (caspase-activated DNase) that causes the apoptotic DNA fragmentation. We further showed that DNA of apoptotic cells can
be digested not only cell-autonomously by CAD, but also
non-cell autonomously by an acid DNase (DNase II) in
macrophages. During definitive erythropoiesis, nuclei are expelled from erythroid precursor cells and engulfed by macrophages. We found that DNase II is also responsible for degrading nuclear DNA from erythroid precursor cells. The
DNase II-null mice accumulate undigested DNA in macrophages, and activate the inflammatory cytokine genes such as
IFN and TNF . This led to the severe lethal anemia in
mouse embryos, and chronic polyarthritis in adults that resembles to human rheumatoid arthritis.
Using the knowledge that DNA of apoptotic cells is cleaved
in lysosomes of macrophages after they are phagocytosed, we
established an assay system for phagocytosis of apoptotic
cells, and identified of a factor (MFG-E8) and a receptor
(Tim-4) that specifically bind to apoptotic cells by recognizing phosphatidylserine exposed on the surface of dead cells.
MFG-E8 is expressed in the tingible-body macrophages in the
germinal centers of the spleens. Many apoptotic cells are left
unengulfed in the MFG-E8-/- tingible-body macrophages, and
the mutant mice develop SLE (systemic lupus erythematosus)-type autoimmune diseases, confirming that apoptotic
cells must be swiftly cleared to prevent the release of antigenic materials from dying cells. We recently showed that
similar to apoptotic cells, the nuclei from erythroid cells also
expose phosphatidylserine on their surface to be recognized
by macrophages.
Publications:
Hanayama et al., Science (2004) 304(5674): 1147-50.
Yoshida et al., Nature (2005) 437(7059): 754-58.
Kawane et al., Nature (2006) 443(7114): 998-1002.
Miyanishi et al., Nature (2007) 450(7168): 435-39.
Professor:
NAGATA, Shigekazu, D.Sc. (Tokyo Univ.), Cell Death and
Cytokine
FUKUNAGA, Rikiro, D.Sc. (Kyoto Univ.), Cytokine signaling
and Gene expression
KAWANE, Kohki, D.Med.Sc. (Osaka Univ.), Mouse genetics
and Immunology
HANAYAMA, Rikinari, M.D., D.Med.Sc. (Osaka Univ.),
Phagocytic signaling and diseases
DEPARTMENT OF CELL BIOLOGY
The predecessor of this Department is the second
sub-department of the Department of Medical Chemistry. In
1961, the Department of Medical Chemistry was divided into
two sub-departments. Dr. Hayaishi was the chairman of the
Department and the Professor of the first sub-department, but
in the second sub-department two Associate Professors were
appointed until Dr. Shosaku Numa was appointed as the first
Professor in 1968. Since then, the chairmanship has been
rotated. Regrettably Dr. Numa died in February of 1992 just
before his retirement. Dr. Shoichiro Tsukita was appointed
as the second Professor to succeed Dr. Numa in May of 1993,
and this second sub-department was reorganized into the Department of Cell Biology in 1994. In 2007, Dr. So Iwata was
appointed as the third professor in the Department.
The Department of Cell Biology is responsible for instruction in biochemistry and molecular biology for undergraduate
and graduate students.
(see also http://cell.mfour.med.kyoto-u.ac.jp/ ):
Professor Iwata, started work on membrane protein crystallography in 1992. Since then, he has been trying to solve
various types of membrane proteins from prokaryote to eukaryote. Membrane proteins perform a wide range of biological functions including respiration, signal transduction and
molecular transport. The results of various genome projects
have shown that up to 30 % of proteins encoded by eukaryotic
cells are membrane proteins. Structural research on membrane
proteins is, however, only a partially conquered area; less than
20 independent structures of integral membrane proteins have
been reported so far. A more fundamental understanding of
the structure-function relationships of membrane proteins
would make invaluable contributions to structural biology,
pharmacology and medicine. The Mission of our group is to
develop new techniques for crystallization and structural determination, which will lead to a breakthrough in the structural studies of a wide range of membrane proteins.
Professor:
IWATA, So, Ph.D. (Univ. of Tokyo), Membrane protein X-ray
crystallography;
Senior Lecturer:
KOBAYASHI, Takuya, D.Med.Sc. (Kyoto Univ.), Production
and purification of functional membrane protein for crystallography;
MURATA, Takeshi, D.Eng. (Tokyo Univ. Science), Development of binders increasing hydrophilicity and crystallizability
of membrane protein;
ADACHI, Makoto, D.Sc. (Kyoto Univ.), Cell adhesion and
signaling;
DEPARTMENT OF MOLECULAR ONCOLOGY
Our group has discovered several mammalian genes based
on their activity to suppress malignant phenotype or their
characteristic spatio-temporal expression patterns in mice.
These include RAP1/Krev-1, RECK, caspase-2/Nedd2,
Medicine
Nedd4, Sept2/Nedd5, Nedd8, and Nedd9. We are attempting
to elucidate their physiological functions and their roles in
diseases such as cancer and neurological disorders using experimental systems in vitro and in vivo. We also collaborate
with clinicians to explore the relevance of these molecules in
human diseases and possible clinical application of the materials obtained though these studies.
Besides its main programs on Molecular Oncology for
graduate students, this department takes part in other courses
for medical students, including Essential Cell Biology and
Molecular Cell Biology.
Professor:
NODA, Makoto, D.Med.Sc. (Keio Univ.), Isolation and characterization of genes involved in cancer formation and embryonic development;
MATSUZAKI, Tomoko, D.Med.Sc. (Tokyo Medical and Dental
Univ.), Functions of RECK protein;
YOSHIDA, Yoko, D.Pharm.Sc. (Tokyo Univ. of Pharmacy and
Life Sciences), Molecular mechanisms of tumor invasion and
metastasis;
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infertile animals, GS cells can produce normal fertile offspring, indicating that they are real stem cells.
GS cells have several advantages over ES cells. First, although ES cells are only available during the embryonic period, GS cells can be derived from postnatal animals. Second,
they are not tumorigenic and committed to the germline lineage. Given that ES cells with germline potential have been
obtained only from mice, our GS cell technology may resolve
current challenges with ES cells and greatly contribute to the
development of new transgenic technologies. We are now
trying 1) to modify the genome of rat GS cells and 2) to derive GS cells from other animal species.
Professor:
SHINOHARA, Takashi, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Spermatogonial transplantation; 2. Production of transgenic
animals;
Assistant Professors :
LEE, Jiyoung, Ph.D. (Tokyo Institute of Technology), 1. Genomic imprinting, 2. Nuclear Cloning;
SHINOHARA, Mito, M.D., D.Med.Sc. (Kyoto Univ.), 1. Germline stem cell culture; 2. Production of transgenic animals;
TAKASHIMA, Seiji, Ph.D. (Tokyo Institute of Technology), 1.
Genomic imprinting, 2. Embryo Culture;
IMAMURA, Yukio, D.Med.Sc. (Kyoto Univ.), Molecules involved in the regulation of neural activity and plasticity;
Program-Specific Researcher (Global Centers of Excellence (GCOE)):
KITAYAMA, Hitoshi, D.Sc. (Univ. of Tsukuba), Functions of
transformation suppressor genes;
MEDICAL GENETICS
Few areas of medicine remain unaffected by the rapid developments in molecular genetics that have taken place over
recent years. Not only the classic Mendelian disorders, but
also diseases of complex and multifactorial etiology are now
subject to investigation at the DNA level. Moreover, gene
therapies are expected to become important therapueutic modalities in the new century. To study and teach medical genetics at the molecular level, the Medical Genetics consists of
three departments.
DEPARTMENT OF MOLECULAR GENETICS
Germ cell biology and transgenesis are the fields for which
we are responsible in both undergraduate and graduate
courses.
There are two main projects in our department. One is development of technique to manipulate male germline stem
cells. The other subject is to understand the biology of male
germline stem cells. In 2003, we succeeded in long-term culture of mouse spermatogonial stem cells. Due to their unique
morphology and biological characteristics, we named them
germline stem (GS) cells. GS cells have different morphology from embryonic stem (ES) cells, and can grow exponentially in vitro for more than 2 years. Upon transplantation into
DEPARTMENT OF RADIATION GENETICS
The Department of Radiation Genetics was founded by Dr.
Tsutomu Sugahara for basic research and education in the
field of radiation biology in 1961. Dr. Hiraku Takebe took
over the departmental Head position in 1982, and was followed by Dr. Shunichi Takeda in 1998.
The department now has a solid base of very active research in the field of cellular response to DNA damage, including DNA repair and recombination, DNA damage checkpoint, and cell cycle regulation. Molecular mechanisms linking genetic instability and radiosensitivity with seemingly
unrelated metabolic pathways like cell division and DNA replication are also being investigated. Our studies are relevant to
analysis of oncogenesis caused by genetic instability, as well
as cancer therapy and development of methods for gene therapy. To comprehensively study these DNA transactions, we
have used the chicken DT40 cell line, because it is an ideal
model system for reverse genetic study due to its extremely
high efficiency of gene targeting as well as stable karyotype.
Students can learn basic techniques of molecular biology and
cell culture by making gene disrupted clones from DT40 cells.
We have recently established a reverse genetics approach in
Medaka. In this way, we want to investigate the relevance of
findings from DT40 cells to the function of physiological tissues.
Professor:
TAKEDA, Shunichi, M.D., D.Med.Sc. (Osaka Univ.),
1. Molecular biology; 2. Oncology; 3. Radiation biology;
TANIGUCHI, Yoshihito, M.D., D.Med.Sc. (Keio Univ.),
1. Molecular Biology; 2. Radiation Biology;
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MOTEGI, Akira, M.D., D.Med.Sc. (Univ. Tokyo),
1. Molecular Biology; 2. Genetics; 3. Radiation Biology;
HIROTA, Kouji, Ph.D., D.Sc. (Tokyo Univ.),
1. Molecular Biology; 2. Molecular Genetics; 3. Radiation
Biology;
DEPARTMENT OF CLINICAL
MOLECULAR BIOLOGY
To apply molecular medicine to the clinics, many problems
remain to be solved. The current research activities are
mainly focused on the mechanisms of hepatocarcinogenesis,
and temperature stress responses. The individual research
subjects undertaken include:
1. The heat- and cold-shock responses in mammals.
2. The molecular diagnosis and treatment of infertility.
3. The development of molecular tumor markers and therapeutics against liver cancers.
4. The development of vectors for gene therapy.
5. The establishment of genetic counseling network in Japan.
The primary focus of research has been on the neuronal
circuitry, synaptic organization, and development and plasticity of neuronal connection in the central nervous system of
mammals, including man. Various pathways in the brain and
spinal cord are analysed with light and electron microscopies
by means of tracer techniques, immunocytochemistry, in situ
hybridization
histochemistry,
and
intracellular
recording/staining method.
Recently, efforts are strongly focused on the morphological analysis of local circuit or microcircuit in the cerebral
cortex, basal ganglia and thalamus, using genetically modified
animals as well as the conventional methods listed above.
Professor:
KANEKO, Takeshi, M.D., D.Med.Sc. (Kyoto Univ.), Local
neural circuit in the mammalian central nervous system, especially in the cerebral neocortex;
FUJIYAMA, Fumino, M.D., D.Med.Sc. (Saga Univ.),
Neural circuit in the basal ganglia;
Professor:
FUJITA, Jun, M.D., D.Med.Sc. (Kyoto Univ.), 1.Reproductive
biology; 2.Stress responses; 3.Clinical genetics; 4.Oncology;
FURUTA, Takahiro, D.Sc. (Kyoto Univ.), Neural circuit in the
basal ganglia and cerebral cortex;
ITOH, Katsuhiko, M.D., D.Med.Sc. (Kyoto Univ.), 1.Gene
therapy; 2.Experimental hematology;
HIOKI, Hiroyuki, D.Med.Sc. (Kyoto Univ.), Local neural circuit in the cerebral cortex and thalamic nuclei;
HIGASHITSUJI, Hiroaki, M.D., D.Med.Sc. (Kyoto Univ.),
1. Hepatocarcinogenesis; 2.DNA diagnosis;
HIGASHITSUJI, Hisako, M.D., D.Med.Sc. (Kyoto Univ.),
1. Oncology; 2. DNA diagnosis;
Technical Staff:
OKAMOTO-FURUTA, Keiko, 1. Electron microscopy, 2. Photography;
DEPARTMENT OF INTEGRATIVE
BRAIN SCIENCE
http://www.brain.med.kyoto-u.ac.jp/indexe.html
BASIC NEUROSCIENCE
The Basic Neuroscience is dedicated for the integrative
function of the brain. The major research and educational
activities of Basic Neuroscience are made from activities of
four independent departments. They are on the morphological study of the central nervous system (Department of
Morphological Brain Science), on the physiological study of
the nervous system correlating elemental regions of the brain
with its high order integrative functions (Department of Integrative Brain Science), on the neurobiological investigation of
neuronal activities and their signal processing (Department of
Physiology and Neurobiology), and on the neuropharmacological investigation of the nervous system (Department of
Cell Pharmacology).
DEPARTMENT OF MORPHOLOGICAL
BRAIN SCIENCE
http://www.mbs.med.kyoto-u.ac.jp
This Department is responsible for instruction in morphological sciences of the central nervous system for undergraduate and graduate students.
The Department is responsible for teaching 'systems neuroscience' for undergraduate and graduate students.
Research activities are focused on understanding how and
on what basis the brain functions. We address the brain as
an information processing system, and apply neurophysiological techniques to study the function of the intricate neural network that is behind human perception, planned action
and thought. (1) We focus on visual tracking responses of
the eyes to study the transformation of sensory to motor information. We have recorded neuronal activities in different
parts of the brain while monkeys performed visual-oculomotor tasks. We analyzed the data using mathematical methods and revealed the role of the cerebral cortical
area MST and cerebellum in controlling the ocular following
response. To fully understand the function of the brain, we
have found that the simultaneous application of two approaches is the most effective. One is the analytical approach based on the biological properties of the neurons by
electrophysiology, and the other is an integrative high level
systems approach by computational neuroscience. We will
continue to pursue this theme in studying higher brain functions. (2) The second group in our lab is studying neural
mechanisms underlying visual attention that realizes cognitive
Medicine
behaviors using a visual search task. Since visual search is
guided by both bottom-up and top-down attention, it can be a
good model to study the functional roles of feed-forward and
feed-back information signals in the brain. Our studies have
demonstrated the interaction process between the top-down
and bottom-up attentional processes and the neural dynamics
of them over the course of a visual search. We are also
starting a new project focusing on neural mechanisms underlying high-degree intellective behaviors.
Professor:
KAWANO, Kenji, M.D., D.Med.Sc. (Univ. of Tokyo), Neuronal mechanism of information processing for visuo-motor
transformation;
Senior Lecturer:
OGAWA, Tadashi, Ph.D., D. Eng. (Osaka Univ.), Neuronal
mechanism underlying visual attention and intellective behaviors;
NISHIO, Takeshi, M.D., D.Med.Sc. (Kyoto Univ.), Regeneration of neural pathways and reconstruction of neuronal circuitries in the mammalian central nervous system;
MIURA, Kenichiro, Ph.D., D. Eng. (Hosei Univ.), Neural control of eye movements and visual information processing;
DEPARTMENT OF PHYSIOLOGY AND
NEUROBIOLOGY
The department is responsible for undergraduate and
graduate education of physiology in general.
The auditory system has many marvelous capabilities. It
can discriminate a small difference of sound frequency, and it
can identify the location of sound source in high precision.
Although our nervous system is operating by using a clock of
approximately 1 msec, our auditory system can discriminate a
time difference of 10 μsec or less. We are studying how these
capabilities of hearing are realized; trying to understand the
cellular and synaptic mechanisms, how to calculate the interaural differences of time and intensity of sound, and then
how to create a space map of hearing within the human brain.
The primary field of our research is, therefore, the neuroscience. From our series of investigations made on the chick
nervous system using brain slice preparation and in vivo recordings, following neural mechanisms became clear: The
precision of coincidence detection, namely the basic mechanisms for the sound source localization is achieved through
optimization of presynaptic terminal structures, release of
neurotransmitters and postsynaptic membrane excitabilities.
Also cooperative neural mechanisms of time and intensity information of sound were demonstrated in processing neural
information utilized for sound source localization. In these
studies, we utilize various techniques of electrophysiology
both in vitro and in vivo, morphology and molecular biology
depending on the purpose of experiments.
Professor:
OHMORI, Harunori, M.D., D.Med.Sc. (Univ. of Tokyo),
Auditory neuroscience;
ISHII, Takahiro, M.D., D.Med.Sc. (Kyoto Univ.), Molecular
biology of ion channels;
119
YAMADA, Rei, M.D., D.Med.Sc. (Kyoto Univ.), Auditory
neuroscience;
FUKUI, Iwao, D.Med.Sc. (Kyoto Univ.), Auditory neuroscience;
DEPARTMENT OF CELL PHARMACOLOGY
The Department of Pharmacology is offering to undergraduate and graduate students a comprehensive course on
pharmacodynamics and pharmacological basis of therapeutic
drugs. A particular emphasis is put on molecular and cellular mechanisms of drug action.
Outline of Research Activities
(see also http://www5.mfour.med.kyoto-u.ac.jp/):
This Department has identified a variety of signal transduction molecules in the cell by the use of pharmacology, biochemistry, molecular biology and cell biology, and is examining their potentials as targets for new drug development.
The research activities carried out in the Department can be
grouped into three categories.
1) MOLECULAR ANALYSIS OF RHO FUNCTION
Narumiya and Ishizaki’s group is studying the cellular
functions of the Rho family small GTPases, which stimulate
actin reorganization and microtubule stabilization through
their effectors and regulate various cell actions including cell
cycle progression, cell contraction, cell adhesion and nuclear
signaling. This study has also led to the discovery of a selective inhibitor of a Rho-associated kinase, ROCK. Biochemical analysis on cultured cells and generation of
knock-out mice deficient in Rho effectors including ROCK-I,
ROCK-II and three isoforms of mDia family proteins are now
in progress. This research aims to discover new signal
transduction pathways, the manipulation of which may control cancer cell invasion and metastasis, inflammatory cell
migration, cell growth and cell division.
2) PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL
ROLES FOR PROSTANOID RECEPTORS
Narumiya and Furuyashiki's group has made the mice deficient in each of eight types and subtypes of the prostanoid receptors which they cloned. This group is subjecting these
mice to various animal models for human diseases, and examining their phenotypes. They are also examining the effects of type- and subtype-selective synthetic agonists and
antagonists to these receptors. This work has identified and
is identifying the physiological and pathophysiological significances of each receptor in the body, especially in biological adaptations such as allergy, inflammation and neural activation upon stress, and is providing therapeutic strategies to
modulate their actions.
3) SINGLE-MOLECULE SPECKLE BIO-IMAGING PROJECT ON CELL MOTILE PROCESS
Watanabe’s group is elucidating cell motility-associated
cytoskeletal dynamics at the molecular level. In collaboration
with Tim Mitchison, Watanabe developed the fluorescence
single-molecule speckle microscopy that enabled visualization of cellular actin polymerization-depolymerization dynamics at the molecular level. This led to the discovery of
processive actin capping motion of mDia1 and other Formin
proteins. Their high resolution imaging approach has also
120
been applied to the elucidation of the mechanism of action of
anti-cancer drugs. This research is establishing the next
generation of imaging-based research capable of probing
on-going molecular processes directly in live cells.
Professor:
NARUMIYA, Shuh, M.D., D.Med.Sc. (Kyoto Univ.), 1. Cellular functions and signal transduction of the small GTP-binding
protein Rho; 2. Pharmacology and molecular biology of
prostanoid receptors;
WATANABE, Naoki, M.D., D.Med.Sc. (Kyoto Univ.), Single-molecule speckle bio-imaging project on cell motile process;
ISHIZAKI, Toshimasa, M.Sc., D.Med.Sc. (Kyoto Univ.), Cellular functions and signal transduction of the small
GTP-binding protein Rho and its effectors;
FURUYASHIKI, Tomoyuki, M.D.,
D.Med.Sc. (Kyoto Univ.), Molecular and cognitive neuroscience/Pharmacology and molecular biology of prostanoid receptors;
INTERNAL MEDICINE
DEPARTMENT OF HEMATOLOGY
AND ONCOLOGY
The Department of Hematology and Oncology specializes
in the treatment and study of adult hematologic and oncologic
diseases in a multidisciplinary approach. The department has
hematology expertise in the areas of acute leukemia, myeloproliferative disorder, myelodysplastic syndrome, malignant
lymphoma, multiple myeloma, aplastic anemia, thrombocytopenic purpura, hemostasis and thrombosis, and adult T-cell
leukemia/lymphoma that was first described in our department. Treatment modalities include allogeneic and autologous
stem cell transplantation, newly developed chemotherapeutic
agents, and immuno-cell-therapy using dendritic cells. Our
goal is to develop innovative cancer treatments for patients
who do not respond to standard therapies.
We are responsible for instruction in hematology, oncology, and clinical immunology for undergraduate and graduate
students.
The major research fields include 1) molecular basis and
treatment of hematological malignancies, 2) viral oncogenesis
of adult T-cell leukemia/lymphoma, 3) intracellular signaling
pathways in blood cells, 4) molecular mechanism regulating
cell death, 5) development of novel immuno-cell-therapy for
hematological malignancies, 6) characterization and manipulation of dendritic cells, and 7) regulation of HIV replication
by APOBEC3G/Vif system.
Outline of Clinical Activities:
We are responsible for in- and out-patient wards in the
University Hospital, and are taking care of patients with hematological diseases and those with acquired im-
mune-deficiency syndrome.
Professor:
UCHIYAMA, Takashi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Hematology; 2.Leukemia/lymphoma; 3.Immunology; 4.Cytokine;
5.Human retrovirus infections;
Senior lecturers:
ISHIKAWA, Takayuki, M.D., D.Med.Sc. (Kyoto Univ.),
1.Hematology; 2.Stem cell transplantation and allogeneic cell
therapy;
KADOWAKI, Norimitsu, M.D., D.Med.Sc. (Kyoto Univ.),
1.Hematology; 2.Immunology (dendritic cells);
TAKAORI-KONDO, Akifumi, M.D., D.Med.Sc. (Kyoto Univ.),
1.Hematology; 2.HIV; 3.Molecular virology;
ICHINOHE, Tatsuo, M.D., D.Med.Sc. (Kyoto Univ.),
1.Hematology; 2.Adoptive immunotherapy for malignant hematological diseases; 3.Hematopoietic cell transplantation;
KONDO, Tadakazu, M.D., D.Med.Sc. (Kyoto Univ.),
1. Hematology; 2.Leukemia; 3.Apoptosis;
YAMASHITA, Kouhei, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Hematology; 2. Oncology;
NISHIKORI, Momoko, M.D., D.Med.Sc. (Kyoto Univ.),
1. Hematology; 2. Lymphoma;
KAWABATA, Hiroshi, M.D., D.Med.Sc. (Kyoto Univ.),
1. Hematology; 2. Oncology; 3.Iron metabolism;
HISHIZAWA, Masakatsu, M.D., D.Med.Sc. (Kyoto Univ.),
1. Hematology; 2. Oncology;
KOBAYASHI, Masayuki, M.D., D.Med.Sc. (Kyoto Univ.),
1.Hematology; 2. Oncology; 3. Signal transduction;
DEPARTMENT OF MEDICINE AND
CLINICAL SCIENCE
Recent studies demonstrate that not only classical endocrine organs but also virtually every tissue and organ possess
the endocrine function. Based on this new concept of endocrinology and metabolism, we, the members of Department of
Medicine and Clinical Science (Endocrinology and Metabolism) are focusing upon the diseases of endocrinology and
metabolism, especially the metabolic syndrome, which is
so-called “life style-related diseases,” such as obesity, diabetes mellitus, hypertension and hyperlipidemia, and is the
cluster of risk factors for atherosclerosis. We are also investigating the pathogenesis of the syndrome and its complications,
and performing translational research for the development of
new therapeutic strategies.
The department is responsible for instruction in endocrinology and metabolism including metabolic syndrome and its
cardiovascular complications in the field of internal medicine
for undergraduate and graduate students.
1. Pathogenesis of obesity and its complications
Medicine
2. Pathogenesis of diabetes mellitus and its complications
3. Pathogenesis of hypertension and its cardiovascular complications
4. Renal complications of metabolic syndrome and gout
5. Adrenal diseases
6. Neuroendocrinology and pituitary diseases
7. Bone diseases and osteoporosis
8. Thyroid diseases
Responsible for out-patient clinic and medical ward of 45
beds in the field of endocrinology and metabolism including
metabolic syndrome.
Professor:
NAKAO, Kazuwa, M.D., D.Med.Sc. (Kyoto Univ.), 1. Endocrinology and metabolism; 2. Hypertension; 3. Obesity and
diabetes mellitus;
MUKOYAMA, Masashi, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Endocrinology and metabolism; 2. Nephrology; 3. Hypertension; 4. Gout;
Senior Lecturers:
TAMURA, Naohisa, M.D., D.Med.Sc. (Kyoto Univ.), 1. Endocrinology and metabolism; 2. Hypertension; 3. Adrenals; 4.
Atherosclerosis and vascular medicine;
MASUZAKI, Hiroaki, M.D., D.Med.Sc. (Kyoto Univ.), 1. Endocrinology and metabolism; 2. Obesity and diabetes mellitus; 3. Lipid metabolism;
(Industry-Government-Academia Collaboration)
MORI, Kiyoshi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Endocrinology and metabolism; 2. Nephrology; 3. Gout;
KUWAHARA, Koichiro, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Endocrinology and metabolism; 2. Cardiology;
KASAHARA, Masato, M.D., D.Med.Sc. (Shiga Medical Univ.),
1. Endocrinology and metabolism; 2. Nephrology;
EBIHARA, Ken, M.D., D.Med.Sc. (Tohoku Univ.), 1. Endocrinology and metabolism; 2. Obesity and diabetes mellitus;
HARADA, Masaki, M.D., D.Med.Sc. (Kyoto Univ.), 1. Endocrinology and metabolism; 2. Cardiology;
YASODA, Akihiro, M.D., D.Med.Sc. (Kyoto Univ.), 1. Endocrinology and metabolism; 2. Bone and mineral metabolism;
3. Osteoporosis;
SONE, Masakatsu, M.D., D.Med.Sc. (Kyoto Univ.), 1. Endocrinology and metabolism; 2. Hypertension; 3. Atherosclerosis and vascular medicine; 4. Adrenals;
KANAMOTO, Naotetsu, M.D., D.Med.Sc. (Mie Univ.), 1. Endocrinology and metabolism; 2. Thyroid;
FUJIKURA, Junji, M.D., D.Med.Sc. (Kyoto Univ.), 1. Endocrinology and metabolism; 2. Obesity and diabetes mellitus;
NAKAGAWA, Yasuaki, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Endocrinology and metabolism; 2. Cardiology;
(Industry-Government-Academia Collaboration)
YOKOI, Hideki, M.D., D.Med.Sc. (Kyoto Univ.), 1. Endocri-
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nology and metabolism; 2. Nephrology;
MIYAMOTO, Licht, Ph.D. (University of Tokyo), 1. Obesity
and diabetes mellitus; 2. Molecular Biology;
DEPARTMENT OF CARDIOVASCULAR
MEDICINE
Teaching Activities:
This department is responsible for instruction in dynamics
of blood circulation, cardiovascular diseases that include
congestive heart failure, cardiac arrhythmias, ischemic heart
disease, myocardial disorders, valvular heart disease, atherosclerosis, large vessel diseases, peripheral vascular obstructions, arteritis, and essential/renovascular hypertension for
undergraduate and graduate students.
Clinical Activities:
The department undertakes diagnosis and treatment of cardiovascular diseases, including primary intensive care, interventions on coronary arteries and other peripheral vascular lesions, pharmaco medical managements, rehabilitation, and the
long-term follow-up.
Research projects include clinical and experimental studies
on etiology and pathophysiology of the cardiovascular diseases. Clinical prospective studies on sudden cardiac death
in poor cardiac function, short and long-term outcomes after
coronary interventions focusing on drug eluting stent, thrombosis regulation focusing on anti-platelet therapy, and establishment of aortic stent-grafting for patients with aortin aneurythm are in progress. Basic research on heartfailure metabolic syndrome, arrhythmia, thrombosis regulation, development of heart, and tissue regeneration are undertaken using
molecular biological, biochemical, and cell biological methods together with gene knock-out and transgenic mice.
Professor Emeritus:
KITA, Toru, M.D., D.Med.Sc. (Kyoto Univ.), 1. Cardiovascular medicine; 2. Atherosclerosis; 3. Molecular biology
Associate Professors:
KIMURA, Takeshi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Cardiovascular medicine; 2. Percutaneous coronary intervention;
3. Clinical outcome study;
MATSUMORI, Akira, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Myocarditis; 2. Cardiomyopathy; 3. Molecular cardiology; 4.
Heart failure;
Associate Professors (Sponsored Research Program):
NISHI, Eiichiro, M.D., D.Med.Sc. (Kyoto Univ.), 1. Molecular
biology; 2. Development of cardiovascular system;
Senior Lecturers:
KUME, Noriaki, M.D., D.Med.Sc. (Kyoto Univ.), 1. Cardiovascular medicine; 2. Atherosclerosis; 3. Molecular biology;
HORIUCHI, Hisanori, M.D., D.Med.Sc. (Kyoto Univ.), 1. Cardiovascular Medicine; 2. Regulation of thrombosis formation;
SHIOI, Tetsuo, M.D., D.Med.Sc. (Kyoto Univ.), 1. Cardiovascular Medicine; 2. Heart failure
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YUI, Yoshiki, M.D., D.Med.Sc. (Kyoto Univ.), 1. Ischemic
heart disease; 2. Cardiovascular epidemiology;
KISHIMOTO, Chiharu, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Cardiomyopathy; 2.Cardiovascular immunology; 3. Redox
regulation;
AKAO, Masaharu, M.D., D.Med.Sc. (Kyoto Univ.), 1. Electrophysiology; 2. Cell signaling;
ONO, Koh, M.D., D.Med.Sc. (Kyoto Univ.), 1. Ischemic heart
disease; 2. Heart failure;
SHIZUTA, Satoshi, M.D., 1.Arrhythmia; 2.Heart failure;
3.Ischemic heart disease;
Assistant Professors (Sponsored Research Program):
HIRAOKA, Yoshinori, D. Eng. (Tokyo Institute of Technology),
1.Molecular biology; 2. Cell biology
HORIGUCHI, Masahito, M.D., D.Med.Sc. (Kyoto Univ.) 1.
Development of cardiovascular system; 2. Extracellular matrix
MARUSAWA, Hiroyuki, M.D., D.Med.Sc. (Kyoto Univ.),
Hepatology;
MIYAMOTO, Shin-ichi, M.D., D.Med.Sc. (Kyoto Univ.), Gastroenterology;
UEDA, Yoshihide, M.D., D.Med.Sc. (Kyoto Univ.), Hepatology;
WATANABE, Tomohiro, M.D., D.Med.Sc. (Kyoto Univ.),
Gastroenterology;
TADA, Shinsuke, M.D., D.Med.Sc. (Kyoto Univ.), Hepatology;
EZOE, Yasumasa, M.D. (Kyoto Univ.), Gastroenterology;
HORIMATSU, Takahiro, M.D. (Kyoto Univ.), Gastroenterology;
IDA, Hiroshi, M.D. (Kyoto Univ.), Hepatology;
KOMEKADO, Hideyuki, M.D., D.Med.Sc. (Kyoto Univ.),
Gastroenterology;
DEPARTMENT OF RESPIRATORY MEDICINE
Shogoinkawara-cho, Sakyo-ku, Kyoto 606-8507
Tel: (+81)-75-751-3830, Fax: (+81)-75-751-4643,
DEPARTMENT OF GASTROENTEROLOGY
AND HEPATOLOGY
http//www.kukonai.com/
This department is responsible for instruction in gastroenterology and hepatology in the field of internal medicine for
undergraduate and graduate students.
This department is responsible for instruction in Respiratory Medicine in the field of internal medicine for undergraduate and graduate students.
The major fields in research are follows:
1. Molecular and cellular biology of gastrointestinal tract
2. Carcinogenesis and cell differentiation in gastrointestinal
tract
3. Immunology in digestive organ
4. Endoscopic diagnosis and treatment for digestive disease
5. Molecular and immunological aspects in viral hepatitis and
hepatocarcinogenesis
6. Hemodynamics in hepatic disorders
7. Liver transplantation
The major fields in the research are follows:
1. Chronic Obstructive Pulmonary Disease (COPD)
2. Interstitial Lung Disease
3. Bronchial Asthma
4. Lung Cancer
5. Pulmonary Infectious Disease
6. Pulmonary Vascular Disease
7. Sleep Apnea and Hypopnea Syndrome
8. Respiratory Insufficiency
The department is responsible for an out-patient clinic and
a medical ward of 45 beds in the field of gastroenterology and
hepatology.
Professor:
CHIBA, Tsutomu, M.D., D.Med.Sc. (Kyoto Univ.), 1. Gastroenterology; 2. Hepatology;
Associate Professors
MUTO, Manabu, M.D., D.Med.Sc. (Kyoto Univ.), Gastroenterology;
WATANABE, Norihiko, M.D., D.Med.Sc. (Kyoto Univ.), Gastroenterology;
Senior Lecturers:
NAKASE, Hiroshi, M.D., D.Med.Sc. (Kyoto Univ.), Gastroenterology;
NISHIDA, Naoshi, M.D., D.Med.Sc. (Kyoto Univ.), Hepatology;
SENO, Hiroshi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Gastroenterology, 2. Hepatology;
The Department is responsible for an out-patient clinic and
a medical ward of 60 beds in the field of Respiratory Medicine.
Professor:
MISHIMA, Michiaki, M.D., D.Med.Sc. (Kyoto Univ.), 1.
COPD, 2. Bronchial asthma, 3. Pulmonary circulation, 4.
Respiratory insufficiency;
NIIMI, Akio, M.D., D.Med.Sc. (Kyoto Univ.), 1.Asthma,
2.Chronic cough;
Senior Lecturers:
HIRAI, Toyohiro, D.Med.Sc. (Kyoto Univ.), COPD;
MURO, Shigeo, D.Med.Sc. (Kyoto Univ.), COPD;
MATSUMOTO, Hisako, D.Med.Sc. (Kyoto Univ.), Asthma;
Medicine
ITO, Yutaka, D.Med.Sc. (Kyoto Univ.), Infectious disease;
OGAWA, Emiko, D.Med.Sc. (Kyoto Univ.), COPD;
KIM, Young Hak, M.D., Thoracic Oncology;
DEPARTMENT OF RHEUMATOLOGY
AND CLINICAL IMMUNOLOGY
This department has been newly established in October,
2000 and expected as a leader for Rheumatology and Clinical
Immunology in Japan. The department is responsible for the
clinical diagnosis, management and therapy for many patients
with systemic autoimmune diseases, such as systemic lupus
erythematosus (SLE), rheumatoid arthritis (RA), systemic
sclerosis (SSc), polymyositis/dermatomyositis (PM/DM), any
kind of vasculitis syndrome including polyarteritis nodosa
(PN), and other connective tissue diseases.
The department is responsible for teaching immune diseases (S9) to undergraduate students and for instructing basic
and clinical studies in rheumatology and clinical immunology
to graduate students. We are also responsible for clinical
training of clinical fellows and residents in the department of
University Hospital.
To investigate the pathogenesis of rheumatic and autoimmune diseases, we focus on the following subjects:
1. Identification of new autoantigens and their biological
function
2. Pathogenic autoantigens and autoantibodies in rheumatoid
arthritis and other rheumatic diseases
3. Autoreactive T cells in systemic lupus erythematosus
4. Establishment of new gene therapy for autoimmune diseases
5. Study of disease-susceptibility genes in systemic autoimmune diseases.
6. Diagnosis and management of the intractable manifestations in autoimmune diseases
Professor:
MIMORI, Tsuneyo, M.D., D.Med.Sc. (Keio Univ.), 1. Rheumatology; 2. Clinical immunology; 3. Autoantibody; 4.
Autoantigen;
Associate Professor (Concurrent post):
USUI, Takashi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Rheumatology; 2. Clinical immunology; 3. Molecular immunology; 4.
Cellular immunology;
Senior Lecturer:
FUJII, Takao, M.D., D.Med.Sc. (Keio Univ.), 1. Rheumatology; 2. Clinical immunology; 3. Cellular immunology; 4.
Autoreactive T cells; 5. Autoantibody;
KAWABATA, Daisuke, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Rheumatology; 2. Clinical immunology; 3. Autoantigen;
OHMURA, Koichiro, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Rheumatology; 2. Clinical immunology; 3. Genomic research;
4. Autoantibody;
NOJIMA, Takaki, M.D., D.Med.Sc. (Keio Univ.), 1. Rheuma-
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tology; 2. Clinical immunology; 3. Autoantibody; 4. Osteoimmunology;
YUKAWA, Naoichiro, M.D. (Tokyo Medical Univ.), 1. Rheumatology; 2. Clinical immunology; 3. Clinical therapy; 4.
Rheumatoid Arthritis;
DEPARTMENT OF GERIATRIC MEDICINE
Our research activities focus on the pathogenesis of those
diseases afflicting the old people as cardio-and cerebrovascular disorders, cancers, infectious diseases and cognitive impairments. These are leading causes of death for the majority of adults and older generations in our rapidly aging society.
1. Immunopathogenesis of alimentary tract disorders and a
virulence mechanism of Helicobacter pylori.
2. Pathogenesis of atherosclerosis and renal diseases due to
dyslipidemia and diabetes mellitus.
3. Diagnosis and prevention of dementia and cognitive disorders.
4. Comparative field studies on the well being of the old people in various cohort groups both domestic and abroad.
5. Studies on both ethical and medical aspects of nutrition of
old patients with terminal illness.
6. Molecular mechanisms of cellular senescence and prevention of aging-associated clinical disorders.
We also commit ourselves to develop team-based approaches in our clinical services.
Senior Lecturers:
WAKATSUKI, Yoshio, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Immunology; 2. Microbiology;
ARAI, Hidenori, M.D., D.Med.Sc. (Kyoto Univ.), 1. Atherosclerosis and vascular cell biology;
TAKECHI, Hajime, M.D., D.Med.Sc. (Kyoto Univ.), 1. Geriatric medicine; 2. Molecular neurology;
KONDOH, Hiroshi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Ageing
and senescence biology; 2. Geriatiric Medicine;
HAMAKAWA, Yoshiyuki, M.D., D.Med.Sc. (Okayama Univ.),
1. Geriatric medicine; 2. Clinical neurology;
DEPARTMENT OF DIABETES AND CLINICAL NUTRITION
The preceding Nutritional Care Unit was founded in 1933
for clinical nutrition and diet therapy in Kyoto University
Hospital. It became the Division of Clinical Nutrition in
1981 as a central clinical facility. In 1992, department was
reestablished as the Department of Metabolism and Clinical
Nutrition to reflect its academic and scientific roles of providing advanced instruction to medical student in the field of
metabolism and nutrition as well as research opportunities for
graduate students in diabetology and nutriology. The name
of the department was further altered to the Department of
Diabetes and Clinical Nutrition in 2002 to play a central role
in the field of diabetology in Kyoto University Hospital.
Our major interest is to clarify the pathogenesis of diabetes
mellitus and to develop a cutting-edge therapy, from multidisciplinary aspects. Our studies include the production and
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secretion of insulin in pancreatic -cells, regeneration and
transplantation of pancreatic -cells, various effects of incretins including GIP and GLP-1, search for novel metabolic
sensor in vivo, clinical characterization of Japanese diabetic
patients, and establishment of evidence in nutrition.
OHTSURU, Shigeru, M.D., 1. Gastroenterology; 2. Hepatology
SUZUKI, Takao, M.D., D.Med.Sc.
Director and Professor:
INAGAKI, Nobuya, M.D., D.Med.Sc. (Kyoto Univ.), 1. Diabetes mellitus; 2. Clinical Nutrition:
The Department of Nephrology was founded as the Division of Artificial Kidneys of Kyoto University Hospital in
1970s and became the department in 2002. The Department
has contributed to the progress in basic and clinical nephrology, and specializes in the treatment and study of various
kidney diseases. The number of patients with end-stage renal
disease (ESRD) is still increasing, and therefore the therapeutic advancement for ESRD is becoming highlighted. Among
renal diseases, diabetic nephropathy is now the leading cause
of ESRD worldwide. Moreover, recent studies have revealed
that mild chronic renal dysfunction, irrespective of its causes,
increase the risk for death and cardiovascular events, and is
thus regarded as a new disease entity called chronic kidney
disease (CKD). The Department focuses upon the pathophysiology and therapeutics of kidney diseases from various
causes and of various stages as follows:
1) Diagnosis and treatment of primary glomerular diseases:
glomerulonephritis and nephrotic syndrome
2) Diagnosis and treatment of diabetic nephropathy, with special emphasis on early diagnosis and intensive therapy for
diabetic nephropathy to achieve its remission and regression
3) Diagnosis and treatment of other secondary glomerular
diseases and CKD: hypertensive nephrosclerosis, gout kidney, ischemic nephropathy, polycystic kidney disease, and
collagen diseases
4) Management of chronic renal failure, with special interest
in the therapy with the renin-angiotensin system blockade
to get regression
5) Dialysis therapy for ESRD and management of its complications: hemodialysis and peritoneal dialysis
6) Blood purification: hemodiafiltration, plasma exchange,
plasma adsorption, and apheresis
7) Diagnosis and treatment of electrolyte and body fluid imbalance
Senior Lecturers:
HOSOKAWA, Masaya, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Diabetes mellitus; 2. Clinical Nutrition:
FUJIMOTO, Shimpei, M.D., D.Med.Sc. (Kyoto Univ.),
1.Diabetes mellitus; 2. Clinical Nutrition:
Program-Specific Senior Lecturer (Special Appointment):
HARASHIMA, Shinichi, M.D., Ph.D. (Kyushu Univ.), 1. Diabetes mellitus; 2. Clinical Nutrition:
NAGASHIMA, Kazuaki, M.D., Ph.D. (Chiba Univ.), 1. Diabetes mellitus; 2. Clinical Nutrition:
HAMAMOTO, Yoshiyuki, M.D., D.Med.Sc. (Kyoto Univ.), 1.
TOYODA, Kentaro, M.D., D.Med.Sc. (Kyoto Univ.), 1. Diabetes mellitus; 2. Clinical Nutrition:
HAMASAKI, Akihiro, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Program-Specific Assistant Professors (Special Appointment):
YAMADA, Chizumi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Diabetes mellitus; 2. Clinical Nutrition:
NAKAMURA, Yasuhiko, Ph.D. (Kyushu Univ.), 1. Diabetes
mellitus; 2. Biochemistry:
HARADA, Norio, M.D., D.Med.Sc. (Kyoto Univ.), 1. Diabetes
mellitus; 2. Clinical Nutrition:
DEPARTMENT OF PRIMARY CARE AND EMERGENCY MEDICINE
All patients with acute illness (1.cardiovascular,
2.neurovascular, 3.gastrointestinal, 4.respiratory tract,
5.metabolic and endocrine, 6.renal diseases) and trauma are
triaged and treated immediately after arrival to emergency
room in cooperation with all other clinical sections.
Professor :
KOIKE, Kaoru, M.D., D.Med.Sc.(Nihon Med. Sch.),
D.Pharm.Sci. (Showa Univ.), 1. Emergency medicine; 2. Surgery
MATSUDA, Naoyuki, M.D., D.Med.Sc.
SOMA, Toshiya, M.D., D.Med.Sc.(Kyoto Univ.), Surgery
YAMAHATA, Yoshihiro, M.D., Emergency medicine
NISHIYAMA, Kei, M.D., Cardiovascular diseases
DEPARTMENT OF NEPHROLOGY
The Department is responsible for instruction in basic and
clinical nephrology including chronic kidney disease, acute
and chronic renal failure, dialysis therapy and its complications, blood purification, and electrolyte and body fluid balance in the field of internal medicine for undergraduate students and clinical trainees.
1. Pathogenesis of diabetic nephropathy
2. Early diagnosis and new treatment of diabetic nephropathy
3. Pathogenesis and treatment of glomerulonephritis and
nephrotic syndrome
4. Pathogenesis and management of ESRD
5. Management of acute renal failure
6. Hemodialysis and its complications
7. Peritoneal dialysis and its complications
The Department of Nephrology is responsible for the
out-patient clinic and medical ward of 14 beds in the field of
kidney diseases. In cooperation with the Division of Artificial
Medicine
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Kidneys, the Department is responsible for dialysis therapy
and blood purification for in-patients with ESRD, hepatic
failure, autoimmune diseases, post-transplant state, drug poisoning, and other acutely ill conditions such as systemic inflammation response syndrome. The Department is also responsible for blood access surgery and peritoneal dialysis induction. In cooperation with the Department of Medicine and
Clinical Science, the Department takes care of education and
management for out-patients with renal diseases.
ology of dermal connective tissue; 2. Connective tissue diseases;
Senior Lecturers:
TAKAHASHI, Kenzo, M.D., D.Med.Sc. (Kyoto Univ.), 1. Molecular biology of keratin; 2. Wound healing; 3.Basic research
for development of new drugs for keratoderma.;
Senior Lecturer:
FUKATSU, Atsushi, M.D., D.Med.Sc.(Nagoya Univ.)
IEHARA, Noriyuki, M.D., D.Med.Sc.(Kyoto Univ.)
MATSUBARA, Takeshi, M.D., D.Med.Sc.(Kyoto Univ.)
MATSUMURA, Yumi, M.D., D.Med.Sc. (Kyoto Univ.),
Hematodermatology;
IKOMA, Akihiko, M.D., D.Med.Sc. (Kyoto Univ.),
Neurophysiology of itch;
ARAKAWA, Akiko, M.D., D.Med.Sc. (Kyoto Univ.), 1,
hair biology, 2,Autoimmunity 3, Tumor immunity;
KORE-EDA, Satoshi, M.D., D.Med.Sc. (Kyoto Univ.) Skin
surgery;
CUTANEOUS LIFE SCIENCE
DEPARTMENT OF DERMATOLOGY
The Department of Dermatology was founded in 1899
soon after the College of Medicine was established. Dr. T.
Matsuura, the first director, studied Schistosomiasis japonica.
The second director, Dr. S. Matsumoto, conducted
well-known studies on spirochaetal diseases such as syphilis.
He became a Member of the Japan Academy in 1949 and was
awarded with Order of Cultural Merit by the Japanese Government in 1966 as well as with Schaudinn-Hoffman Prize by
the German Dermatological Association in 1965. The third
director, Dr. T. Yamamoto, studied the relationship between
skin and systemic diseases. The fourth director, Dr. S. Ofuji,
investigated the pathogenesis of eczematous skin diseases,
especially atopic dermatitis from an immunological point of
view. Dr. S. Imamura became the fifth director in 1980 and
studied the pathogenesis of erythema multiforme. The present Professor, Dr. Y. Miyachi became the sixth director in
1998. There are 10 academic staffs, 12 graduate students, 3
adjunctive physician scientists and 5 residents. Several foreign research fellows from Korea, China, Taiwan, Bangladesh,
Brazil and Indonesia have studied in the laboratories.
1. Pathogenesis of allergic and inflammatory skin diseases.
2. Immunobiological studies of skin diseases
3. Molecular and biochemical studies on skin diseases.
4. Cutaneous regeneration studies and wound healing
Most research works in this department have been published in international journals.
There are 130-150 outpatients/day and 20-23 inpatients.
Over 250 day surgeries are performed every year. A special
leprosy clinic is open twice a week.
Professor:
MIYACHI, Yoshiki, M.D., D.Med.Sc. (Kyoto Univ.), 1. Cutaneous allergic inflammation; 2. Photobiology and Cutaneous
Aging; 3. Wound healing;
UTANI, Atsushi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Cell bi-
HONDA, Tetsuya, M.D., D.Med.Sc. (Kyoto Univ.), Lipid
mediator and skin immunology
KITOH, Akihiko,M.D., Immunology;
KATOH, Mayumi, M.D., Skin surgery;
DEVELOPMENTAL MEDICINE
DEPARTMENT OF PEDIATRICS
54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507
Tel. (+81)-75-751-3291, Fax. (+81)-75-752-2361
The Department of Pediatrics was established in 1903. Dr.
I. Hirai, the founder of the department, was honoured with the
prestigious Academy Prize of the Japan Academy for his scientific contributions on lead poisoning in Japanese infants in
1932. He was followed by Dr. M. Suzuki (1927-1931), Dr. S.
Hattori (1931-1951), the former Presidents of Kyoto University, Dr. H. Nagai (1951-1966), Dr. R. Okuda (1966-1979),
former vice President of the Fukui Medical School, Dr. H.
Mikawa (1979-1993) and Dr. K Furusho (1994-1998). Dr. T
Nakahata is the eighth Professor of the Department, serving
from 1999. The present staff includes sixteen faculty members,
nine clinical fellows, eight rotating residents and nineteen
postgraduate students and five research fellows.
Outline of Teaching Activities
This department is responsible for general and special instruction on the diagnosis and treatment of pediatric diseases
for undergraduate and graduate students. There is a daily
general outpatient clinic and 6 special out-patient clinics for
cardiovascular diseases, malignancy and hematological diseases, allergy and immunological diseases, neuromuscular
diseases, neonatological diseases and metabolic and endocrinological diseases. The Department is responsible for an
in-patient clinic with a general ward containing thirty-five
hospital beds.
Outline of Research Activities
There are at present 5 research groups;
1. Stem Cell (Hematology, Immunology, Neurology and Cardiology): Expansion and differentiation of tissue stem cells
and ES cells, and their clinical applications
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2. Allergy and Immunology: Cellular and molecular mechanisms of allergic and immunological diseases, Clinical and
epidemiological studies of childhood allergic diseases to
elucidate more effective therapy
3. Metabolism/Endocrinology and Genetics: Molecular basis
of inherited metabolic diseases, Molecular genetics of
Turner's syndrome
4. Apoptosis: Molecular analysis of apoptosis and its regulation with the aim of clinical application
Professor:
NAKAHATA, Tatsutoshi, M.D., D.Med.Sc. (Shinsyu Univ.),
Hematology and oncology
HEIKE, Toshio, M.D., D.Med.Sc. (Kyoto Univ.), Immunology
and allergology
Senior Lecturers:
YORIFUJI, Tohru, M.D., D.Med.Sc. (Kyoto Univ.), Metabolism/endocrinology and genetics
ADACHI, Souichi, M.D., D.Med.Sc. (Kyoto Univ.), Hematology and oncology
KAWAI, Masahiko, M.D., D.Med.Sc. (Kyoto Univ.), Metabolism and endocrinology
NISHIKOMORI, Ryuta, M.D., D.Med.Sc. (Kyoto Univ.), Immunology and allergology
DOI, Hiraku, M.D., (Kyoto Univ.), Cardiology
WATANABE, Ken-ichiro, M.D., D.Med.Sc. (Kyoto Univ.), Hematology and oncology
YASUMI, Takahiro, M.D., D.Med.Sc. (Kyoto Univ.), Immunology and allergology
HIRAMATSU, Hidefumi, M.D., D.Med.Sc. (Kyoto Univ.), Hematology and oncology (on leave of absence)
KATO, Takeo, M.D., D.Med.Sc. (Ehime Univ.), Neurology
MATSUBARA, Hiroshi, M.D., (Asahikawa Med. College), Hematology and oncology
YAMANAKA, Yasunari, M.D., D.Med.Sc. (Kyoto Univ.), Neurology
UMEDA, Katsutsugu, M.D., D. Med.Sc. (Kyoto Univ.), Hematology and oncology (on leave of absence)
NIWA, Fusako, M.D., (Nara Med. Univ.), Neonatology
FUJINO, Hisanori, M.D., D. Med.Sc. (Kyoto Univ.), Hematology and oncology
BABA, Shiro, M.D., D.Med.Sc. (Shiga Univ. of Med. Science),
Cardiology
RADIOLOGY
The history of the Department of Radiology dates back to
1944, when the Section of Applied Physical Science for
Medical Use was established. This section became the Department of Radiology, supervised first by Dr. I. Suetsugu in
1948. He was urged to establish the basis for diagnostic as
well as therapeutic radiology. In 1950 he succumbed to
pancytopenia due to an occupational radiation injury. Dr. T.
Fukuda succeeded him in 1951 and worked mainly with diagnostic radiology of the alimentary tract and with radiation
protection as well as therapy.
Responding to increased demands for clinical as well as
basic radiological science, the Radiology and Nuclear Medicine Service was established in the University Hospital under
Dr. Fukuda in 1964. Since then, various uses of radioisotopes
for clinical medicine have yielded new fields of nuclear
medicine, from which the third Professor of radiology, Dr. K.
Torizuka, was elected in 1972. Under these conditions, the
Department of Radiology has necessarily expanded its field of
activity. When Dr. Torizuka moved to the newly established
Department of Nuclear Medicine in 1976, Dr. M. Abe succeeded as the fourth Professor of the Department of Radiology in 1977, and the staff of radiology and nuclear medicine
were united in order to utilize a variety of radiological tools
synergistically for mutual benefit and also in the hope of
combined use of new tools such as computed tomography
(CT), ultrasound, magnetic resonance imaging (MRI) and
positron study. In this sense, the Department has become a
unique organization that keeps pace with recent developments
in medical technology, through the diagnostic tools applying
X-rays, gamma rays, nuclear magnetic resonance, and so on,
and radiation therapy. In 1987, Dr. J. Konishi succeeded Dr.
Torizuka as the second Professor of the Department of Nuclear Medicine. In 1995, Dr. M. Hiraoka succeeded Dr. Abe as
the fifth Professor of the Department of Radiology. Since the
reorganization of Graduate School of Medicine in 1995, the
Department of Radiology has been reformed as the Department of Therapeutic Radiology and Oncology, and the Department of Nuclear Medicine has been reformed as the Department of Nuclear Medicine and Diagnostic Imaging. In
2004, Dr. K. Togashi succeeded Dr. Konishi as the third Professor of the Department of Nuclear Medicine and Diagnostic
Imaging. In 2005, both departments changed their names to
the Department of Radiation Oncology and Image-applied
therapy and the Department of Diagnostic Imaging and Nuclear Medicine, respectively. The present staff in the two Departments consists of 29 faculty members and 2 clinical fellows. 20 graduate students and 4 residents engage in activities
that cross the boundary between the two departments. There
are 27 beds used for diagnosis and therapy for in-patient care.
The subjects of research work (excluding the faculty members
of the Radiology and Nuclear Medicine Service) of the two
Departments are as follows.
DEPARTMENT OF RADIATION ONCOLOGY AND
IMAGE-APPLIED THERAPY
The department is responsible for instruction in radiation
oncology and interventional radiology for undergraduate and
graduate students.
At the radiotherapy clinic, a total number of about 1,200
new patients have been treated by radiotherapy per year. A
multidisciplinary treatment using chemotherapy is also performed for various malignancies. Innovative treatments
such as stereotactic irradiation, intensity-modulated radiotherapy (IMRT), intraoperative radiotherapy, brachytherapy
and total body irradiation are intensively performed. Radioisotope therapy using Iodine-131 is carried out for thyroid
cancer.
The research projects currently in progress in the Department are as follows: modification of radiosensitivity, bioimaging, hypoxia targeting therapy, hyperthermia, intraoperative radiotherapy, a 4-dimensional treatment planning system,
IMRT, stereotactic irradiation, and integrated radiotherapy
systems.
Intravascular radiotherapy using glass microspheres are also being investigated.
Medicine
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radiotherapy; 2. Radiation Physics;
Professor:
HIRAOKA, Masahiro, M.D., D.Med.Sc. (Kyoto Univ.), 1. Radiotherapy in general; 2. Hyperthermic oncology; 3. Clinical
radiobiology; 4. Radiotherapy for breast cancer;
Program-Specific Professor (CK Project):
KONDOH, Shinae, D.Med.Sc. (Osaka Univ.), 1. Molecular
Oncology; 2. In vivo optical imaging; 3. Molecular Genetics;
4.Tumor Virology;
MITSUMORI, Michihide, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Radiotherapy for breast cancer and gastrointestinal cancers;
2. 3-dimensional treatment planning; 3. Hyperthermic oncology;
Senior Lecturer:
MIZOWAKI, Takashi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Intensity-modulated radiation therapy and stereotactic irradiation; 2. Radiotherapy for prostate, head & neck and esophageal cancer; 3. Radiotherapy treatment planning;
Program-Specific Senior Lecturer (Science and Technology Advancement):
HARADA, Hiroshi, D. Sci., (Nagoya Univ.), 1. Radiation Oncology, 2. Molecular Oncology, 3. Molecular Imaging;
SHIBUYA, Keiko, M.D., D.Med.Sc. (Kyoto Univ.), 1. Radiotherapy for intra-thoracic tumors, pancreatic cancer and
GYN; 2. Radiation biology;
YAMAUCHI, Chikako, M.D., M.Med.Sc. (Mie Univ.), 1. Radiotherapy for breast cancer and GYN; 2. Brachytherapy;
MATSUO, Yukinori, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Stereotactic irradiation and intensity-modulated radiotherapy; 2. Radiotherapy for lung and head & neck cancer;
HORII, Naotoshi, M.D., M.Med.Sc. (Fukui Univ.), 1. Radiotherapy for head & neck cancer; 2. Hyperthermic oncology; 3.
Brachytherapy;
ITASAKA, Satoshi, M.D., M.Med.Sc. (Kyoto Univ.), 1. Radiotherapy for gastrointestinal cancers; 2. Radioisotope
therapy; 3. Radiation Biology;
Program-Specific Assistant Professors
(Reform Promotion):
NORIHISA, Yoshiki, M.D., M.Med.Sc. (Ehime Univ.), 1. Intensity-modulated radiation therapy and stereotactic irradiation; 2. Radiotherapy for prostate cancer;
Program-Specific Associate Professor
(Reform Promotion):
NARITA, Yuichiro, D. Eng. (Tohoku Univ.), 1. Medical Physics for radiotherapy; 2. Radiation Physics; 3. Nuclear Engineering;
Program-Specific Associate Professor
(NEDO Industry-Government–Academia Collaboration):
SAWADA, Akira, D.Eng. (Kyoto Univ.), 1. Medical physics in
radiotherapy; 2. Medical image processing; 3. Engineering
for Image-guided radiation therapy;
Program-Specific Assistant Professors
(Industry-Government–Academia Collaboration):
SATO, Sayaka, M.Eng. (Tohoku Univ.), 1. Medical Physics for
radiotherapy; 2. Radiation Physics;
MIYABE, Yuki, M.H.Sc (Osaka Univ.), 1. Medical Physics for
DEPARTMENT OF DIAGNOSTIC IMAGING
AND NUCLEAR MEDICINE
The Department is responsible for teaching in diagnostic
radiology, CT, MRI, ultrasonography and nuclear medicine
for undergraduate and graduate students. We wish to serve
not only for residents who will be a radiologist but also for
residents that are scheduled to be doctors in other departments,
because imaging is mandatory in all the medical fields.
The department has committed to medical services to patient with a variety of diseases on the basis of imaging, providing a full-range of diagnostic services utilizing diagnostic
imaging modalities such as X-ray CT, MRI, ultrasonography,
as well as nuclear medicine techniques including positron
emission tomography. Interventional radiology that incorporates both diagnosis and treatment is another service, which
we have been providing. We also have outpatient clinic and
radioisotope treatment facility for patients with thyroid diseases.
The major research interests include: (1) physical/mathematical investigations for development of new imaging modalities and image processing methods, (2) clinical
investigations on the establishment of a new imaging methods
to clarify the mechanism of disease, and (3) basic research on
the image findings with a pathophysiological approach. We
are also concerning with basic experimental studies such as
molecular imaging, evaluation of angiogenesis, oxygenation,
and blood flow with a use of state-of-the-art imaging technique.
Professor:
TOGASHI, Kaori, M.D., D.Med.Sc. (Kyoto Univ.), 1. Integrated medical imaging using CT, MRI, radioisotope imaging
and ultrasonography; 2 Women’s imaging using MRI
MIKI, Yukio, M.D., D.Med.Sc. (Kyoto Univ.) 1. Diagnostic
neuroradiology; 2. Neuroimaging using CT and MRI
Senior Lecturer:
ISHIZU, Koichi, M.D., D.Med.Sc. (Kyoto Univ.), Radionuclide imaging of the brain
NAKAMOTO, Yuji, M.D., D.Med.Sc. (Kyoto Univ.),
Oncological nuclear medicine, General radiology
KAWASHIMA, Hidekazu, D.Pharm.Sci. (Kyoto Univ.), 1. Radiopharmaceutical chemistry; 2. Biochemistry of drugs
NAKAI, Asako, M.D., D.Med.Sc. (Kyoto Univ.), 1. Integrated
medical imaging using CT, MRI, radioisotope imaging and
ultrasonography;
YAMAMOTO, Akira, M.D., D.Med.Sc. (Kyoto Univ.), General
radiology
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CLINICAL PATHOLOGY
DEPARTMENT OF CLINICAL
LABORATORY MEDICINE
This department was established as the Department of
Laboratory Medicine in April 1984. The Professor and faculty members supervise the Central Clinical Laboratories, and
most of the members are also in charge of infection control
and prevention in the University Hospital. At present, the
department has six faculty members as listed below and two
clinical fellows and one graduate student.
Our mission is to develop young, promising clinicians and
investigators who will take an active part internationally in
the fields of clinical infectious diseases, infection epidemiology, and clinical microbiology. The department is responsible for teaching the laboratory diagnosis (I4) and infectious
diseases (S8) to undergraduate medical students. Training
and research courses for Ph.D. and D.Med.Sc. degrees are offered to graduate students.
We have been providing a sophisticated consultation service regarding efficient diagnostic procedures and appropriate
management of the patients with severe infection, which has
resulted in a steady improvement of the prognosis for patients
with nosocomial sepsis. We are also conducting surveillance
of postoperative or post-transplantation infections, exploring
effective strategies for the prevention and control of these
infections.
To identify clinical evidence leading to more efficient
management of infectious diseases, we are conducting researches in cooperation with many industry develop novel
diagnostic methods and to put them to practical use. We are
also continuing to pursue the application of scientific findings
for the diagnosis, control as well as prevention of nosocomial
infection, with the aim of putting everyday medical practice
regarding infectious diseases on a foundation of scientific rationality.
Professor:
ICHIYAMA, Satoshi, M.D., D.Med.Sc. (Nagoya Univ.), 1.
Laboratory medicine; 2. Clinical microbiology; 3. Molecular
biology;
IINUMA, Yoshitsugu, M.D., D.Med.Sc. (Nagoya Univ.), 1.
Clinical microbiology; 2. Laboratory medicine; 3. Infectious
diseases;
Senior Lecturers:
ITO, Junko, M.D., D.Med.Sc. (Kyoto Univ.), 1. Neurology; 2.
Clinical neurophysiology; 3. Laboratory medicine;
TAKAKURA, Shunji, M.D., D.Med.Sc. (Kyoto Univ.), 1. Infectious diseases; 2. Clinical microbiology; 3. Laboratory
medicine;
SAITO, Takashi, M.D., D.Med.Sc. (Okayama Univ.), 1. Infectious diseases; 2. Clinical microbiology; 3. Laboratory medicine;
SURGERY
DEPARTMENT OF GASTROINTESTINAL SURGERY
Department of Gastrointestinal Surgery was founded in
2006 through the reorganization of Department of Surgery.
This department focuses on surgical treatments of gastrointestinal (esophageal, gastric, colorectal) carcinomas, inflammatory bowel diseases and morbid obesity. Recent advances in
laparoscopic surgery have led us to minimally invasive, yet
more refined operation compared with classical
open-abdominal surgery. The finest-quality laparoscopic
surgeries performed in our division are reflection of the rigorous surgical training and sturdy basic surgical research.
This division is responsible for general instruction on the
gastrointestinal surgery for undergraduate and graduate students.
The major fields in research are as follows;
1. molecular biological analysis of gastrointestinal carcinomas
to estimate the prognosis or the efficacy of chemoradiotherapy
2. evaluation of gastrointestinal physiology after surgical
procedures
3. development of new imaging system to unveil and understand more details of surgical anatomy
4. development of novel surgical procedures and surgical instruments
5. active involvement in the multi-institutional clinical studies
to evaluate outcomes of surgical treatments
Professor:
SAKAI, Yoshiharu, M.D., D.Med.Sc. (Kyoto Univ.), 1. Colorectal surgery; 2. Laparoscopic surgery;
Lecture:
KUBO, Hajime, M.D., D.Med.Sc. (Kyoto Univ.),
Gastrointestinal surgery
OKABE, Hiroshi, M.D., D.Med.Sc. (Kyoto Univ.),
ITAMI, Atsushi, M.D., D.Med.Sc. (Kyoto Univ.),
NAGAYAMA, Satoshi, M.D., D.Med.Sc. (Kyoto Univ.),
NOMURA, Akinari, M.D.,
KAWAMURA, Jun-ichiro, M.D., D.Med.Sc. (Kyoto Univ.),
OBAMA, Kazutaka, M.D., D.Med.Sc. (Kyoto Univ.),
TANAKA, Eiji, M.D., D.Med.Sc. (Kyoto Univ.),
DEPARTMENT OF HEPATOPANCREATOBILIARY
SURGERY AND TRANSPLANTATION
Department of Surgery had been consisted of three departments, such as Department of Surgery and Surgical Basic
Science, Department of Gastroenterological Surgery, and Department of Transplantation and Immunology. Since April
2006, Department of Surgery has been reorganized into three
Medicine
divisions, such as Department of Gastrointestinal Surgery,
Hepatopancreatobiliary (HPB) Surgery and Transplantation,
and Department of Breast Surgery. The Department of HPB
Surgery and Transplantation focuses on surgery of the hepatobiliary system and pancreas, liver transplantation and pancreatic islet transplantation, and pediatric surgery.
This department is responsible for general instruction on
the gastroenterological surgery in co-operation with the Department of Gastrointestinal Surgery, for undergraduate and
graduate students. This department is also responsible for
promotion of specialists in the field of HPB surgery, liver
transplantation and pediatric surgery.
129
on the treatment of breast diseases particularly breast cancer.
Currently a number of novel ideas, concepts, new methodologies have been incorporated into the diagnosis and treatment of breast cancer. In order to develop these advances further, we are enthusiastic about improving the multidisciplinary therapy system, discovering new diagnostics, therapeutic
methods, training and educating breast specialists. In collaboration with other departments and institutions, we are keen on
conducting clinical researches especially clinical trials and
correlative researches.
Outline of teaching activities:
1. Learning about breast cancer oncology.
2. Training of breast surgery.
3. Learning and training of multidisciplinary treatments.
Clinical research:
1. Multimodality treatment of hepatocellular carcinoma.
2. Multimodality treatment of pancreatic cancer.
3. Extended resection of cancer in biliary system.
4. Living donor liver transplantation, with a special focus on
liver regeneration.
5. Treatment of pancreatic endocrine tumors with original localization method.
6. Pancreatic islet transplantation.
7. Pathogenesis and pathophysiology of biliary atresia.
Basic Research:
1. Regenerative medicine, with a special focus on regeneration of hepatic and pancreatic stem cells.
2. Pathophysiology of nonparenchymal liver cells.
3. Molecular embryology of pancreas.
4. Molecular biology of hepatopancreatobiliary cancer cells.
5. Tolerance induction by using regulatory T cells in the field
of liver transplantation.
6. New method of pancreatic islet transplantation using
bio-nano-technology
7. New method liver transplantation using chimera-liver
8. Strategy of overcoming small-for-size graft in liver transplantation using new preservation solution
Professor:
UEMOTO, Shinji, M.D., D.Med.Sc. (Kyoto Univ.),
1. Liver Transplantation; 2. Hepato-biliary surgery
Associate Professor
IKAI, Iwao, M.D., D.Med.Sc. (Kyoto Univ.),
1. Hepato-biliary surgery; 2.Regeneration medicine
TAKADA, Yasuji, M.D., D.Med.Sc. (Kyoto Univ.),
1. Liver Transplantation; 2. Hepato-biliary surgery
Senior Lecturers:
DOI, Ryuichiro, M.D., D.Med.Sc. (Kyoto Univ.),
1. Hepato-biliary and pancreatic surgery; 2. Surgical oncology
TAKAORI, Kyouichi, M.D., D.Med.Sc. (Kyoto Univ.),
1. Hepato-biliary and pancreatic surgery; 2. Liver Transplantation
OKAMOTO, Shinya, M.D., D.Med.Sc. (Kyoto Univ.),
1. Pediatric surgery; 2. Liver Transplantation
DEPARTMENT OF BREAST SURGERY
The Department of Breast Surgery was established within
the Department of Surgery in 2007. This department focuses
Outline of research activities and clinical trials:
1. Molecular mechanisms of breast cancer progression and
therapeutic response.
2. Development of new treatment algorithm of primary
breast cancer.
3. Development of new methodologies for minimally invasive surgery.
4. Development of novel breast cancer therapeutics.
5. Regeneration of adipose tissue.
Professor:
TOI, Masakazu M.D., D.Med.Sc., (Hiroshima Univ.),
Breast Surgery
SUGIE, Tomoharu M.D.,Med.Sc. (Kyoto Univ.),
Breast Surgery
UENO, Takayuki, M.D., D.Med.Sc. (Karolinska Univ.),
Breast surgery
YAMASHIRO, Hiroyasu, M.D., D.Med.Sc. (Kyoto Univ.),
Breast Surgery
CLINICAL SCIENCES FOR SURGICAL STRESSES
DEPARTMENT OF ANESTHESIA
The Department of Anesthesia was founded in 1956, when
Dr. Akira Inamoto was promoted from associate professor of
surgery to professor and chairman of the department. At that
time the techniques of anesthesia in Japan were far behind
those of western countries, and Dr. Inamoto devoted himself
mostly to promoting modern practices of anesthesia throughout western Japan. Many of the faculty members went to
western countries to learn modern anesthesiology soon after
the department was founded. Most of them have become professors of medical schools or directors of anesthesia at various
institutions. Dr. Inamoto, who was previously a neurosurgeon,
had a special interest in neurophysiology of anesthesia and
promoted basic researches in this field. Because of his contribution to the founding of modern anesthesia in Japan, scientific activities, and international collaborations, he was
elected as Fellow of the Faculty of Anesthetists of the Royal
College of Surgeons of England in 1976. When Dr. Inamoto
retired in 1973, Dr. Kenjiro Mori was promoted to a full
professorship and took over the chair of the department. Dr.
Mori was famous for neurophysiological research on general
anesthetics and analysis of stress responses induced by
surgical operations. He was elected as Fellow of Royal College
130
of Surgeons for his academic achievement and international
contribution. After Dr. Mori' s retirement, Dr. Kazuhiko Fukuda succeeded as the third professor of the department in
1998.
In 1987, the Division of Critical Care Medicine began activities, which have been taken over by doctors from the Department of Anesthesia. In 2000, the Division of Day Surgery
Unit was established and ambulatory anesthesia service was
included in the clinical activities of the department.
The present departmental staff includes 7 faculty members,
9 clinical fellows, and 7 postgraduate students. The department contributes to patient care in many aspects: the perioperative management including preoperative evaluation
and intra- and postoperative care; the intensive care of critically injured or otherwise seriously ill patients; the diagnosis
and treatment of pain caused by a variety of pathogenesis; the
cardiopulmonary resuscitation.
The area of research includes:
1) molecular biology of anesthesia and critical care medicine
2) neuroscience of anesthesia
3) endocrinology of surgical stress and anesthesia
4) clinical studies of pain management
5) clinical studies of organ transplantation and critical care
medicine
6) clinical studies of ambulatory anesthesia
The molecular biology group succeeded in; cDNA cloning
of three different opioid receptors, attempts to elucidate cellular responses induced by opioids, and analyses of gene expression changes induced by perioperatively used drugs. The
neuroscience group analyzes anesthetic/pain-induced changes
of the CNS activity and neurotransmitter release. The endocrinology group attempts to clarify the mechanisms of stress
responses, and also tries to develop better perioperative management to eliminate the excessive stress response. The clinical pain group attempts total elimination of postoperative pain,
chronic intractable pain and cancer pain, and has recently
started clinical study of electric convulsion therapy for complex regional pain syndrome. The critical care group deals
with the management of organ transplantation and critically ill
patients. The ambulatory anesthesia group makes efforts to
establish the safety and efficiency of the management.
Professor:
FUKUDA, Kazuhiko, M.D., D.Med.Sc. (Kyoto Univ.), 1. Molecular pharmacology of opioids and anesthetics; 2. Clinical
anesthesia;
Senior Lecturers:
HIROTA, Kiichi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Physiology of hypoxia; 2. Ambulatory anesthesia
KURATA, Jiro, M.D., D.Med.Sc. (Kyoto Univ.), Functional
MRI of anesthesia and pain
FURUTANI, Hidekatsu, M.D., D.Med.Sc. (Kyoto Univ.),
Management of pain, Palliative medicine
ISHII, Hisanari, M.D., D.Med.Sc. (Kyoto Univ.), Anesthesia
for cardiovascular surgery
SHODA, Takehiro, M.D., D.Med.Sc. (Kyoto Univ.), Pharmacology of opioid analgesics
UGA, Hisatoshi, M.D., Peripheral nerve block
SURGERY FOR VISCERAL ORGANS
DEPARTMENT OF GYNECOLOGY AND
OBSTETRICS
The Department of Gynecology and Obstetrics was
opened in 1901 and has been directed by a succession of distinguished Professors. Dr. Katsutake Azuma (1901-1906)
founded a general therapeutic system. Dr. Shohei Takayama
(1906-1921) is known for his invention of surgical treatment
for uterine cervical cancer with an improvement of the
Weltheim method. Dr. Hidekazu Okabayashi (1922-1937)
established a systematic procedure for radical hysterectomy,
the Okabayashi method, which has been widely accepted as a
standard procedure for cervical cancer in Japan. Dr. Ryukichi Mibayashi (1938-1961) developed a surgical technique for
advanced cervical cancer known as the Mibayashi operation,
and also promoted ultrastructural studies in gynecology. Dr.
Toshio Nishimura (1961-1981) was renowned as an educator,
and also produced research on carbohydrate and lipid metabolism during pregnancy. Dr. Shimpei Tojo (1982) investigated the molecular biology of placental hormones. Dr. Takahide Mori (1983-1997) expanded the research on reproductive immunology and endocrinology, and developed the in vitro fertilization (IVF) program. Dr. Shingo Fujii, the present
professor (1997-) is known for his work on pathogenesis of
uterine myomas and gynecologic malignancies. He is also
clarifying fine anatomy of uterine cervical ligaments to improve operative procedure of cervical cancer. The present
staff consists of 13 faculty members, 6 clinical fellows, 10
graduate students, 2 research fellows from foreign countries,
and 8 residents.
Undergraduate students are given systematic lectures on
gynecology and obstetrics, and also involved in bedside practice under instruction of faculty members. Residents are
trained for two years to obtain the basic capability of primary
care in gynecology and obstetrics. A clinical conference on
Wednesday, and slide conferences on gynecological pathology
three times a week are open for undergraduate students.
The Laboratories are organized to cover various research
fields, such as gynecologic oncology, maternal and fetal
medicine, and reproductive biology and medicine. The ongoing research projects are:
1. Molecular mechanisms of development of gynecological
neoplasms
2. Development of novel immune therapies and gene therapies for gynecological malignancies
3. Clinical management and pathogenesis of uterine leiomyoma and endometriosis
4. Maintenance of pregnancy and initiation of parturition
5. Management of pregnancy with pre-eclampsia and diabetes
mellitus
6. Clinical and basic studies on intrauterine fetal growth and
maturation
7. Regulatory mechanisms of ovarian and endometrial function
8. Immunology and endocrinology in fertilization and implantation
9. Basic studies on IVF and other assisted reproductive technologies
Medicine
The outpatient clinic consists of specialists in perinatology,
gynecology, and infertility. The inpatient clinic accommodates 58 beds in the gynecologic ward and 27 beds in the obstetric ward. The number of patients admitted each year is
approximately 400 with benign and malignant gynecologic
diseases, 350 with normal and high-risk pregnancies, and 200
for the program of IVF or other assisted reproductive
technologies.
Professor:
KONISHI, Ikuo, M.D., D.Med.Sc. (Kyoto Univ.), 1. Gynecologic oncology; 2. Pathology; 3. Endocrinology;
Senior Lecturers:
FUJIWARA, Hiroshi, M.D., D.Med.Sc. (Kyoto Univ.), Reproductive endocrinology and immunology;
MANDAI, Masaki, M.D., D.Med.Sc. (Kyoto Univ.), Gynecologic oncology and pathology;
TATSUMI, Keiji, M.D., D.Med.Sc. (Kyoto Univ.), Reproductive immunology and endocrinology;
FUKUHARA, Ken, M.D., D.Med.Sc. (Kyoto Univ.), Reproductive immunology and endocrinology;
TAKAO, Yumi, M.D., D.Med.Sc. (Kyoto Univ.), Reproductive
immunology and endocrinology;
KAKUI, Kazuyo, M.D., D.Med.Sc. (Kyoto Univ.), Perinatology;
SATO, Yukiyasu, M.D., D.Med.Sc. (Kyoto Univ.), Reproductive endocrinology and immunology;
YAGI, Haruhiko, M.D., D.Med.Sc. (Kyoto Univ.), Gynecologic oncology and pathology;
SUZUKI, Ayako, M.D., (Kyoto Univ.), Gynecologic oncology
and pathology;
MATSUMURA, Noriomi, M.D., D.Med.Sc. (Kyoto Univ.), Gynecologic oncology and pathology;
BABA, Tsukasa, M.D., D.Med.Sc. (Kyoto Univ.), Gynecologic
oncology and pathology;
DEPARTMENT OF UROLOGY
Kawahara-cho 54, Shogoin, Sakyo-ku, Kyoto 606-8507
Tel: +81-75-751-3337
Fax: +81-75-751-3740
The Department of Urology was founded in 1934. Since
then, the department has made a significant contribution to the
progress of basic and clinical urology. The department has
cultivated many young urologists and produced graduates
who have directed urological departments in other medical
schools and major hospitals. The main themes of this department are focused on the following clinical and basic investigations;
1) Urologic Oncology: Development of new molecular diag-
131
nostic and therapeutic modalities in cancers of the kidney,
bladder, prostate, and testis
2) Urologic Surgery: New operative methods including
laparoscopic surgery
3) Kidney Transplantation and Nephrology: Molecular
pathophysiology in urological nephropathies, and novel
methods for preservation of donor kidney
4) Bladder dysfunction: Clinical and basic investigation on
pathophysiology of adult and pediatric bladder diseases, including nocturia, bladder outlet obstruction, and interstitial
cystitis.
5) Male Infertility: Basic molecular mechanism and innovative clinical trials
Our department staff includes 10 faculty members (1 professor, 1 associate professor, 2 senior lecturers and 6 assistant
professors), 2 clinical fellows, 2 laboratory technicians and 3
secretaries. There are now 11 postgraduate school students.
In addition, 3 doctors are currently engaged in research
abroad. All academic staff members who participate in such
activities are listed below. Numerous national and international collaborative research projects are now in progress.
Foreign researchers are welcome and many of such researchers have done outstanding works and made considerable contribution to our department. This department since 1955 has
published the journal, Acta Urologica Japonica, which is
listed in the Medline, monthly.
This department is responsible for the instruction and bedside clinical training, scientific basics of urology and clinical
general urology for undergraduate and postgraduate school
student. As for the resident training program, each residents
is mainly tutored by an allocated faculty doctor, while all faculty members are also active in playing a tutorial role for each
resident.
This University Hospital has 47 beds in the urological ward.
The number of patients who are newly treated in the outpatient clinic is approximately 4,000 each year. The regular
weekly schedule is as follows: Two days for operations, one
day for medical rounds, two days for clinical conference and
one day for an early morning X-ray conference.
All the faculty members are actively participating in various research projects and play a tutorial role in graduate students' projects. A research conference is held biweekly from
19:00 on Tuesday. The major fields on our researches are
follows:
1) Molecular biology and molecular epidemiology of urogenital cancers
2) Tumor immunology of urogenital cancers
3) Novel chemotherapy and therapeutic modalities against
urogenital cancers
4) Regenerative medicine for urological organs
5) Multidisciplinary investigation of bladder dysfunction
6) Molecular biology on male infertility and novel clinical
approach
Professor:
OGAWA, Osamu, M.D., D.Med.Sc. (Kyoto Univ.), 1. Molecular biology and molecular epidemiology on urogenital tumors; 2. Minimally invasive treatments of urogenital cancers;
132
KAMOTO, Toshiyuki, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Clinical research of prostate cancer; 2. Molecular epidemiology of urogenital cancers; 3. Minimally invasive treatments
of urogenital cancers;
Senior Lecturers:
NISHIYAMA, Hiroyuki, M.D., D.Med.Sc.(Kyoto Univ.), 1.
Molecular biology of urothelial cancer; 2. Basic and clinical
male infertility;
NAKAMURA, Eijiro, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Clinical research and molecular biology of renal cell cancer;
2. Clinical research and molecular biology of prostate cancer;
KANEMATSU, Akihiro, M.D., D.Med.Sc. (Kyoto Univ.),
1.Clinical research on pediatric urology; 2. Basic and clinical
research on bladder dysfunction and regenerative medicine; 3.
Kidney transplantation;
YOSHIMURA, Koji, M.D., (Kyoto Univ.), 1.Clinical epidemiology of voiding dysfunction; 2. Female urology; 3. Minimally
invasive treatments of urogenital cancer;
KANBA, Tomomi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Molecular and cellular biology of renal cancer; 2. Clinical research on prostate cancer; 3. Kidney transplantation;
WATANABE, Jun, M.D., D.Med.Sc. (Kyoto Univ.), 1. Molecular biology of urogenital cancers;
OKUBO, Kazutoshi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Male
infertility; 2. Testicular cancer; 3. Physiology of voiding function;
INOUE, Takahiro, M.D., D.Med.Sc. (Kyoto Univ.), 1. Clinical
and basic research on prostate cancer;
DEPARTMENT OF CARDIOVASCULAR SURGERY
Based on the pioneering achievements by Professors of
Surgery, Yasumasa Aoyagi, Chuji Kimura, and Yorinori Hikasa (known as "Kyoto technique"), the first independent department of cardiovascular surgery in Japanese national universities has been established by Professor Toshihiko Ban in
1984. Dr. Ban as an authority of coronary artery surgery,
made an enormous Kyoto group which consists of more than
30 affiliated hospitals and over 200 related doctors including
those who retired, doing more than 4000 open-heart cases a
year in whole group. From 1998 to 2007, Professor Masashi
Komeda developed both clinical and research aspects of the
department. In 2008, Professor Ryuzo Sakata has taken over
the position and keeps making further refined group in clinical, research, and educational programs.
The department is responsible for undergraduate and
postgraduate education of cardiovascular surgery. The department has several meetings for comprehensive, detailed,
and hands-on teaching especially for residents, in addition to
regular conferences and rounds. Within a year, the in-
terns/residents can learn all important basics of cardiovascular
surgery ranging from etiology, diagnosis, perioperative care of
the patients to surgical strategies and basic/advanced techniques. The education program covers research aspects and
the residents can learn basics of scientific approaches. After
the intensive residency training for 1 year, the young doctor
has further residency training in two affiliated hospitals for
total 6 years. After completing clinical training, the doctor
joins 2 to 4 years' fellowship program for intensive research
or clinical experience in the university which will be followed
by the opportunity for clinical training in North America,
Europe, or Australia/New Zealand.
The department has four major teams:
1. Regenerative medicine (cardiac)
(a) Cell transplantation and cytokine therapy (bFGF,
HGF, IGF) for ischemic heart disease or cardiomyopathy
(b) Langendorff studies
(c) Developing new biomaterials for cardiac surgery
(i.e. surgical glue)
2. Regenerative medicine (thoracic and peripheral vascular)
(a) Therapeutic angiogenesis for lower extremities,
lung, and sternum
(b) Prevention of perioperative infection utilizing regenerative medicine
3. Large animal studies
(a) Scientific development and refinement of procedures for ischemic cardiomyopathy (surgical ventricular restoration and mitral repair)
(b) Novel method for aortic stent graft implantation
(c) Physiologic considerations for cardiac surgery
4. Treatment for congestive heart failure
(a) Optimal medical treatment following surgical
ventricular restoration
(b) Simulation of cardiopulmonary support and
evaluation of its physiology
(c) Regenerative medicine for “Bridge to recovery”
These research programs employs scientific methodology
with the help of basic scientists and engineers but are patient-oriented in their nature. The programs are carefully designed so that every research fellow can improve his/her surgical skills and the project can benefit clinical work. The program welcomes foreign post-doctoral fellows and provides
many research projects.
Professor:
SAKATA, Ryuzo, M.D., D.Med.Sc. (Kyoto Univ.), 1. Surgery
for coronary artery disease; 2. Surgical ventricular restoration for ischemic cardiomyopathy or dilated cardiomyopathy;
3. Surgery for mitral and aortic valve disease; 4. Surgery for
thoracic aortic disease;
IKEDA, Tadashi, M.D., D.Med.Sc. (Kyoto Univ.), 1.Surgery
for congenital heart disease;
Senior Lecturer:
NISHINA, Takeshi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Adult
cardiac surgery; 2. Vascular surgery;
YAMAZAKI, Kazuhiro, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Medicine
Adult cardiac surgery; 2. Vascular surgery;
SAJI, Yoshiaki, M.D., 1. Adult cardiac surgery; 2. Vascular
surgery;
MARUI, Akira, M.D., D.Med.Sc. (Kyoto Univ.), 1. Adult cardiac surgery; 2. Vascular surgery
DEPARTMENT OF THORACIC SURGERY
Basic and clinical studies on lung cancer and mediastinal
tumors have been the main activities of this department since
1951. Various surgical treatments for pulmonary, mediastinal
and chest wall diseases are under continuous investigation.
In April 1998 in acknowledgment of its research and experienced surgical staff, Kyoto University Hospital was approved as one of the lung-transplant centers in Japan.
Current major investigations in the department are: (1)
clinical and basic research for lung transplantation: development of a new lung preservation solution; immunoregulatory
approach to introduce immunotolerance in the recipients; (2)
biological approach for lung cancer: various factors such as
p53, bcl-2, PCNA, thymidylate synthase, CD44, selectins, cyclins and apoptosis index and their relation with prognosis
have been analyzed. Their goal is to develop a new strategy
for lung cancer combined with surgical procedure; (3) multimodality treatment for advanced thoracic malignancies, especially for locally advanced lung cancer or malignant pleural
mesothelioma to improve prognosis.
Several cooperative studies with other institutions in the
domestic area and foreign countries (U.S.A, Canada, Germany,
Sweden, France, and Korea et al.) are underway on lung
transplantation and lung cancer study.
Professor:
DATE, Hiroshi, M.D., D.Med.Sc. (Okayama Univ.),
surgery;
OKUBO, Kenichi, M.D., D.Med.Sc. (Kyoto Univ.),
surgery
MIYAHARA, Ryo, M.D., D.Med.Sc. (Kyoto Univ.),
surgery
SAKAI, Hiroaki, M.D., D.Med.Sc. (Kyoto Univ.),
surgery
SHOJI, Tsuyoshi, M.D., D.Med.Sc. (Kyoto Univ.),
surgery
SONOBE, Makoto, M.D., D.Med.Sc. (Kyoto Univ.),
surgery
SATO, Kiyoshi, M.D., D.Med.Sc. (Kyoto Univ.),
surgery
Thoracic
Thoracic
Thoracic
Thoracic
Thoracic
Thoracic
Thoracic
SURGERY FOR SENSORY AND MOTOR
SYSTEMS
DEPARTMENT OF PLASTIC AND
RECONSTRUCTIVE SURGERY
The Department of Plastic and Reconstructive surgery,
which was officially established in April 1977 was reformed
as the present department in 1987. However, for a long time
before that, many doctors at the Kyoto University Hospital
were actively and exclusively engaged in plastic surgery in
related departments such as dermatology, otolaryngology, oral
surgery, orthopedics and ophthalmology. Dr. Nobuhiko Isshiki
was the founder of the Department and Dr. Yoshihiko Nishi-
133
mura succeeded him in December 1993. Dr. Shigehiko Suzuki
became the third professor in 2003.
The present full-time official staff of the Department includes 1 Professor, 1 Associate Professor, 2 Lecturers, and 3
Assistant Professors almost fully engaged in clinical study
and research. There are 7 clinical fellows and 7 graduate students. The number of surgical cases is approximately 1000
in-and outpatients per year, including cleft lip and palate, facial fracture, microtia and other maxillofacial anomalies,
burns, hand anomalies, and other deformities. Many kinds of
large tissue defects resulting from trauma and post-operative
malignant tumor are covered by free flap transfer with skin,
muscle and bone.
The basic principles of plastic surgery, congenital maxillofacial anomalies, trauma and burns are the main subject of
lectures for undergraduate students, who are also taught at the
daily out-patient clinic and in the surgical room.
Research activities in the department deal chiefly with
maxillofacial plastic surgery, especially cleft lip and palate,
reconstructive microsurgery, skin flap physiology, wound
healing and tissue engineering. Various new techniques for
cleft lip and palate surgery have been devised and reported on
the basis of objective findings obtained by new instrumentation. Current subjects of research under investigation are development of cellular artificial skin, normal and abnormal
wound healing, peripheral and central nerve repair by grafting
both artificial optimal materials and stem cells, regeneration
of bone and cartilage and the genetic etiology of some congenital abnormalities.
Professor:
SUZUKI, Shigehiko, M.D., D.Med.Sc. (Kyoto Univ.),
1. Maxillofacial anomaly; 2. Skin surgery; 3. Wound healing;
4. Regenerative medicine;
NOSE, Kensuke, M.D., D.Med.Sc. (Kyoto Univ.),
1. Maxillofacial anomaly; 2.Skin tumor; 3.Facial injury;
Senior Lecturer:
KAWAI, Katsuya, M.D., D.Med.Sc. (Kyoto Univ.),
1. Maxillofacial surgery; 2. Regenerative medicine; 3. Wound
repair;
Program-specific Senior Lecturer
(New Energy and Industrial Technology Development
Organization <NEDO> Industry-Government-Academia
Collaboration)
NAITOH, Motoko, M.D., D.Med.Sc. (Kyoto Univ.),
1. Wound healing; 2. Keloid; 3.Artificial skin;
MORIMOTO, Naoki, M.D., D.Med.Sc. (Kyoto Univ.), 1. Micro-surgery; 2. Burn;
YAMAWAKI, Satoko, M.D. (Kohchi Med. Univ.), 1. Micro-surgery; 2. Keloid;
FUJIMORI, Hideyuki, M.D. (Osaka Med. Univ.), 1. Micro-surgery; 2.Reconstructive surgery;
134
DEPARTMENT OF OPHTHALMOLOGY
AND VISUAL SCIENCES
The Department of Ophthalmology was established in
1902, and has been directed by the following nine Professors:
Yukujiro Asayama, Kiyoshi lchikawa, Shinnosuke Mori,
Seiichi Yamamoto, Ken lmachi, Ryoji Asayama, Masao Kishimoto, Isamu Tsukahara and Yoshihito Honda. Dr. Nagahisa
Yoshimura was inaugurated as a new professor since April
2004. Clinical and basic research over a wide area of Ophthalmology has been conducted during the past 90 years, and
studies on retinal detachment, which were started by Professor Mori, have been one of the most important research subjects of the department. Professor Ichikawa was famous for
surgical treatments for cataract and glaucoma. The surgical
approach to the optic chiasm in patients with opticochiasmic
arachnoditis was developed by Professor Imachi. Numbers of
distinguished developments have also been achieved in basic
eye research fields including ocular electrophysiology, pathology, histochemistry, biochemistry, and cell biology. The
present staffs of the department include 1 Professor (director),
1 Assistant professor, 2 lecturers, 8 Assistant professors, 11
part-time lecturers, 2 clinical fellows, and 19 post-graduate
students.
OH, Hideyasu, M.D., D.Med.Sc. (Kyoto Univ.),
1.Diabetic retinopathy; 2. Molecular cell biology;
NAKAMURA, Hajime, M.D., D.Med.Sc. (Kyoto Univ.),
1.Electrophysiology; 2. Glaucoma;
NONAKA, Atsushi, M.D., D.Med.Sc. (Kyoto Univ.),
1.Glaucoma; 2. Neuro-ophthalmology;
NISHIJIMA, Kazuaki, M.D., D.Med.Sc. (Kyoto Univ.),
1. Diabetic retinopathy; 2. Molecular cell biology; 3. Uveitis;
TAMURA, Hiroshi, M.D., D.Med.Sc. (Kyoto Univ.),
1.Macular degeneration; 2. Retinal microcirculation;
YAMASHIRO, Kenji, M.D., D.Med.Sc. (Kyoto Univ.),
1. Macular degeneration; 2. Retinal vascular diseases;
OOTO, Sotaro, M.D., D.Med.Sc. (Kyoto Univ.),
1. Macular degeneration; 2. Imaging of ocular tissues;
SAKAMOTO, Atsushi, M.D., D.Med.Sc. (Kyoto Univ.),
1. Imaging of ocular tissues; 2. Glaucoma;
Research:
Research covers the entire field of Ophthalmology.
Clinical research:
1. Macular degeneration
2. Imaging of ocular tissues
3. Glaucoma
4. Retinal vascular diseases
5. Diabetic retinopathy
6. Optic neuritis, Ischemic optic neuropathy
Laboratory research:
1. Stem cell biology
2. Imaging of ocular tissue
3. Molecular mechanism in diabetic retinopathy
4. Blood cell and retinal endothelial cell interaction
5. Retinal and choroidal circulation
Professor:
YOSHIMURA, Nagahisa, M.D., D.Med.Sc. (Kyoto Univ.),
1. Macular degeneration; 2. Molecular cell biology of retina;
3. Neural cell biology;
KITA, Mihori, M.D., D. Med. Sc. (Kyoto Univ.),
1. Diabetic retinopathy; 2. Retinal vascular diseases; 3. Uveitis
Senior Lecturers:
HANGAI, Masanori, M.D., D.Med.Sc. (Kyoto Univ.),
1. Imaging of ocular tissues; 2. Glaucoma;
MIYAMOTO, Kazuaki, M.D., D.Med.Sc. (Kyoto Univ.),
1. Neuro-ophthalmology; 2. Retinal micro-circulation; 3.
Retinal vascular diseases;
OTANI, Atsushi, M.D., D.Med.Sc. (Kyoto Univ.),
1. Macular degeneration; 2. Stem cell biology;
TSUJIKAWA, Akitaka, M.D., D.Med.Sc. (Kyoto Univ.),
1. Macular degeneration; 2. Retinal vascular diseases;
DEPARTMENT OF OTOLARYNGOLOGY-HEAD
AND NECK SURGERY
http://www.kuhp.kyoto-u.ac.jp/~ent/
The Department of Otolaryngology-Head and Neck Surgery was established in 1905. Dr. Haruji Watsuji, the first
Professor, developed a surgical treatment for chronic paranasal sinusitis called Watsuji and Denker's operation. Dr. Teiji
Hoshino, his successor, devoted his life to studies on vestibular physiology. Under Professor Mitsuharu Goto, the main
projects of the department were directed to the studies on laryngeal tuberculosis and also voice and speech science. Dr.
Masanori Morimoto, the fourth Professor, promoted research
in the fields of vestibular and inner ear research, phoniatrics
and maxillofacial surgery. Dr. Manabi Hinoki, the fifth Professor, was deeply involved in promoting basic research in the
field of equilibrium related physiology. Dr. Iwao Honjo was
involved in the research regarding Eustachian tube and hearing science. Dr. Juichi Ito became the seventh Professor of the
department on 1st of February 2000.
Members of the department include 1 Professor (Director),
9 faculty members, 14 part-time lecturers, 3 clinical fellow, 16
post-graduate students, 4 residents and 1 visiting researcher.
The department is responsible for instruction in otology,
otoneurology and laryngology for graduate students. Instruction in general otolaryngology, head and neck surgery is provided for undergraduate students.
The department clinic has 56 beds in the head and neck
surgery ward. 4,500 patients are treated in the out-patient
clinic each year, and approximately 600 patients are operated
on annually. The Department covers all aspects of otolaryngology-head and neck surgery, including:
1. Otological and neurotological surgery
2. Cochlear implantation for the deaf
Medicine
3. Head and neck surgery including skull base surgery
4. Plastic and reconstructive surgery in the head and neck
field
5. Surgery for voice and speech disorders
The major on-going projects in clinical and experimental
studies in the field of Otolaryngology-Head and Neck Surgery
are as follows:
1. Hair cell regeneration for the future treatment of sensorineural hearing disturbance
2. Mechanisms of speech perception in the auditory pathway
including the central nervous system
3. Physiological studies of the hearing and vestibular system
4. Pathophysiology of the middle ear including the Eustachian
tube and the mastoid
5. Basic and clinical studies of voice and speech
6. Central interaction between perception and production of
speech
7. Tissue engineering for regeneration of head and neck organs
Professor:
ITO, Juichi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Neurotology;
2. Vestibular sciences;
Senior Lecturers:
HIRANO, Shigeru, M.D., D.Med.Sc. (Kyoto Univ.),
1 .Laryngology; 2. Clinical oncology
NAKAGAWA, Takayuki, M.D., D.Med.Sc. (Osaka City Univ.),
Neurotology
ASATO, Ryo, M.D., 1. Clinical oncology
TATEYA, Ichiro, M.D., D.Med.Sc. (Kyoto Univ.), 1. Laryngology; 2. Clinical oncology
TAURA, Akiko, M.D., D.Med.Sc. (Kyoto Univ.), 1. Otology; 2.
Vestibular sciences
HIRAUMI, Harukazu, M.D., 1. Audiology; 2. Otology
YAMAMOTO, Norio, M.D., D.Med.Sc. (Kyoto Univ.),
1.Otology; 2. Regenerative Medicine
SAKAMOTO, Tatsunori, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Otology; 2. Rhinology
KITAJIRI, Shin-ichiro, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Otology; 2. Genetics
DEPARTMENT OF ORTHOPAEDIC AND
MUSCULOSKELETAL SURGERY
The Department of Orthopaedic Surgery was opened in
April, 1906, and is known as the longest-standing orthopaedic
clinic in Japan. The first Professor was Dr. Michiharu Matsuoka, who started an out-patient clinic and orthopaedic lectures
for undergraduates in 1906, as the earliest pioneer in Japan.
Since then, the Department has been presided over by five
succeeding Professors: Dr. Yoshitane Ozaki, Dr. Hiromu Ito,
Dr. Eishi Kondo, Dr. Tetsuo Ito, and Dr. Takao Yamamuro.
In earlier days these leaders were professionally influenced by
research in Germany, the United States, and the United Kingdom. This Department has led the orthopaedic surgery in Japan, and its contribution to surgery of the spine is well regarded. Dr. Michiharu Matsuoka began clinical research on
Pott's disease, and was succeeded by Dr. Hiromu Ito who reported a direct anterior approach for the tuberculous spines as
early as 1934. This direct anterior method is now considered
the basis for current spinal surgery, and Dr. Eishi Kondo com-
135
pleted the surgical treatment for many other spinal disorders
such as tuberculosis, intervertebral disc protrusion and cervical osteochondrosis. The fields of hand surgery, surgery of artificial joints and peripheral nerve surgery were added to the
scope of the Department by Dr. Tetsuo lto. At the same time
clinical research on congenital dislocation of the hip joint
started by Dr. Matsuoka has been succeeded to the basic research on collagen fibers and cartilage, and prevention of this
condition by Dr. Takao Yamamuro. Dr. Yamamuro has introduced research works on biomaterials into the Department
and he has finalized the research on newly synthesized artificial bone, which was brought into clinical application in 1990.
Dr. Yamamuro has also very successfully commenced genetic
analysis for malignant bone tumors. Dr. T. Nakamura became
the seventh Professor of the Department on the 1st of February 1995, and he is now directing research projects listed below.
The Department is responsible for instructions in orthopaedic surgery and rehabilitation medicine for undergraduate
and post-graduate students, including anatomy, physiology,
biomechanics, and surgical care of the musculoskeletal system.
The Department holds 5 general out-patients clinics and 6
clinics for orthopaedic subspecialities each week, such as the
clinics for the hips, the hands, the spine, tumors, sports medicine, and rheumatoid arthritis. In addition, there are two biweekly clinics, the clinics for osteoporosis, and generalized
skeletal disorders. The number of out-patients is approximately 26,000 per year. The number of beds in the ward is 57,
and 550 patients are admitted each year. There are 670 operations annually. About 50 orthopaedic clinics in the central part
of Japan are affiliated to the Department.
Current on-going research projects are:
1. Mechanism of bone growth
2. Morphological and biochemical analysis of joint cartilage
disorders
3. Artificial bone
4. Treatment of bone and soft-tissue tumors
5. Cartilage development and differentiation
6. Biodegradable materials
7. Experimental studies on osteoporosis
8. Research on osteoarthritis and rheumatoid arthritis
9. Genetic analysis of malignant bone and soft-tissue tumors
Professor:
NAKAMURA, Takashi, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Joint surgery; 2. Rheumatology and biomaterials;
NEO, Masashi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Spinal
surgery; 2. Biomaterials;
AKIYAMA, Haruhiko, M.D., D.Med.Sc. (Kyoto Univ.), 1. Hip
surgery; 2.bone and cartilage biology;
Senior Lecturers:
KOBAYASHI, Masahiko, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Sports medicine and knee/shoulder surgery; 2. Cartilage metabolism;
NAKAYAMA, Tomitaka, M.D., D.Med.Sc. (Kyoto Univ.),
136
Musculoskeletal tumor surgery;
ITO, Hiromu, M.D., D.Med.Sc. (Kyoto Univ.), 1. Rheumatology; 2. Cartilage biology;
FUJIBAYASHI, Shunsuke, D.Med.Sc. (Kyoto Univ.), 1. Spinal
NAKAMATA, Takeharu, D.Med.Sc. (Kyoto Univ.), Musculoskeletal tumor surgery;
IKEGUCHI, Ryosuke, D.Med.Sc. (Kyoto Univ.), 1. Hand surgery; 2. Peripheral nerve;
TAKEMOTO, Mitsuru, D.Med.Sc. (Kyoto Univ.), 1. Spinal
GOTO, Koji, D.Med.Sc. (Kyoto Univ.), 1. Hip surgery; 2.
Biomaterials;
YOSHITOMI, Hiroyuki, D.Med.Sc. (Kyoto Univ.), Rheumatology;
DEPARTMENT OF ORAL AND
MAXILLOFACIAL SURGERY
The departmental faculty consists of 8 full time faculty
members; a Professor and chair, an Associate Professor, two
Senior Lecturers and four Assistant Professors. The departmental staff includes six clinical fellows, ten residents, thirteen graduate students, and five research associates. Moreover, the postgraduate training program is cooperating with 26
associate hospitals, thus over 80 fellows are actively working
in the Kyoto University Oral and Maxillofacial Surgery Program.
Brief history of the department:
The Department of Oral and Maxillofacial Surgery was
formerly founded as the Department of Stomatology in 1950,
when Dr. Gen Minoguchi was appointed as the Departmental
chairman. During his period of service, until 1973, sophisticated research played a leading role in the fields of Preventive Dentistry, and Biomaterial Science. A comprehensive
study for the prevention of dental caries using fluoride was
carried out as systematic field work in an earlier period.
Another main research subject was basic and clinical study on
the medical application of synthetic PMMA resin in cooperation with the Kyoto University Institute for Chest Diseases.
The latter research group has been currently reoriented as the
Research Center for Biomedical Engineering, and now Research Institute of Frontier Medical Science at Kyoto University. Under the second chairman Professor Takatoki Ono numerous articles were published on clinico-pathological and
immunological studies of the development of dental focal infection. Thereafter the main topics of clinical research have
been directed to advancing Oral and Maxillofacial Surgery
with special reference to the surgical correction of the maxillofacial and jaw deformities, and the medical/surgical management of temporomandibular joint disorders. The official
name of the department was thus changed to the Department
of Oral and Maxillofacial Surgery in 1975. Professor Tadahiko Iizuka was the director of the Department since 1988 to
2003 and he developed the full scope of Oral and Maxillofacial Surgery. Dr. Kazuhisa Bessho became the fourth Professor of the department in 2005.
We have teaching responsibilities for the undergraduate
medical student, postgraduate students, and for the Oral and
Maxillofacial Surgery residency program. The department
serve has employed as an educational facility for the Japanese
Board of Oral and Maxillofacial Surgery, with a large residency program in cooperating with 26 associate hospitals.
1) Molecular biology on health and disease in craniofacial,
and dento-maxillofacial development. 2) Bone induction by
BMP gene transfer using vectors. 3) Dental implant reconstruction and relating tissue engineering. 4) Clinical investigation on Temporomandibular Disorders, Oral Cancer, and
Jaw Deformities. 5) The research on diagnosis and treatment of masticatory muscle tonus and relating disease. Current progress is as follows: 1) Significant advances in the
study of the human crarniofacial development have revealed
the genetic and gene-environment bases of numerous common and rare craniofacial disorders. The characterizations
of genetic mutation may lead to the greater sensitivity and
specificity of molecular-based diagnosis for complex craniofacial disorders including Temporomandibular disorders and
Jaw deformity. 2) We constructed a BMP-2-expressing
adenoviral vector with high efficiency, and succeeded gene
transfer by electroporation with a BMP-2-expressing plasmid
vector. These bone regeneration methods may be useful in
clinic.
3) Basic and clinical research regarding dental implant and maxillofacial reconstruction is actively done in cooperation with Faculty of Engineering and Research Institute
of Frontier Medical Sciences. 4) Regarding research topics
on Temporomandibular joint, the biochemical study of the
synovial fluid is successfully carried out, and currently the
molecular biological study of the disease-susceptibility gene
is actively investigated for the Gene diagnosis of the Temporomandibular disorders. The Oral Cancer investigation
collaborates with the Radiation Oncology Unit on the topic of
concurrent radio-chemotherapy. Distraction oseteo- and
histo-genesis is clinically applied on patients with severe
maxillofacial deformities, and outcomes are discussed. 5)
The diseases relating with abnormal muscle tonus in the
stomatognathic system such as sleep apnea syndrome and
oromandibular dystonia are investigated with the Departments
of Brain Pathophysiology, Neurology, and Human Brain Research Center. Clinically, oral appliances are effectively applied
for the treatment of sleep apnea syndrome.
Professor:
BESSHO, Kazuhisa, D.D.S., D.Med.Sc. (Mie Univ.), 1. Bone
induction by BMP; 2. Regenerative medicine in oral and
maxillofacial surgery;
FUJIMURA, Kazuma, D.D.S., D.Med.Sc. (Kyoto Univ.), 1.
Surgical and medical management of temporomandibular
joint; 2. Maxillofacial trauma and orthognathic surgery;
Senior Lecturers:
NISHIDA, Mitsuo, D.D.S., D.Dent.Sc. (Osaka Dental Univ.), 1.
Oral and maxillofacial oncology; 2. Orthognathic surgery
and orthodontics;
TAKAHASHI, Katsu, D.D.S., D.Med.Sc. (Kyoto Univ.),
Molecular biology in craniofacial research and
oral/maxillofacial surgery;
OHKUBO, Yasunori, D.D.S., D.Med.Sc. (Kyoto Univ.), Bone
induction by BMP gene transfer using vectors;
Medicine
KAIHARA, Shinji, D.D.S., D.Med.Sc. (Kyoto Univ.), Dental
implant and relating tissue engineering;
SONOBE, Junya, D.D.S., D.Med.Sc. (Kyoto Univ.), Osteoinduction by BMP-2 expressing adenoviral vector;
GOTO, Kazuhisa, D.D.S., D.Med.Sc. (Kyoto Univ.), Molecular biology and Patho Hosto Chemistry in infection research
of Bisphosphonates rerated osteonecrosis of the jaw(BRONJ);
CLINICAL NEUROSCIENCE
As the result of the system change from the Faculty of
Medicine to the Post- Graduate Course of Medical Science
that was made in 1995, the Section of Clinical Neuroscience,
which is composed of the three Departments described below,
started in 1995. This Section and the Section of Basic Neuroscience form the Course of Integrated Neuroscience. This
Section was integrated in order to investigate the mechanisms
of brain functions in normal subjects, to clarify the pathology
and pathophysiology of various diseases involving the central
and peripheral nervous system and muscles, and to establish
the diagnostic methods, advanced treatments and prevention
of those diseases.
DEPARTMENT OF NEUROLOGY
The Department of Neurology was founded in the Faculty
of Medicine, Kyoto University in 1979, as the first such department in Japan. Dr. Masakuni Kameyama, known for his
work on cerebrovascular disease, was appointed as the first
Professor and Chairman in April, 1980. Following his retirement in 1987, Dr. Jun Kimura returned from the University of
Iowa as the successor, where he had worked for 28 years, especially as Professor of Neurology there during the last ten
years. In 1989, he was elected as the President of the International Federation of Clinical Neurophysiology. He also served
as the Editor in Chief of Muscle & Nerve. Following his retirement in March 1998, Professor Hiroshi Shibasaki, M.D. of
the Department of Brain Pathophysiology, known as a world
leader of electroneurophysiology of human brain, moved to
the Department of Neurology as the third Chairman in October 1999 and retired in March 2003. Dr. Ryosuke Takahashi
of RIKEN Brain Science Institute was then elected as the
forth Chairman in January 2005. The present staff of the Department includes 6 tenured faculty staffs, 8 clinical fellows,
15 affiliated lecturers, and 17 post-graduate students. Research in this Department covers various fields of neurology,
including cerebrovascular diseases, neurodegenerative diseases,
senile dementia, epilepsy, movement disorders, sleep disorders
and neuromuscular disorders, employing multi-disciplinary
methodologies such as neuropathology, neurochemistry, molecular biology, gene analysis, neuroimmunology, and electrophysiology.
The Department is responsible for teaching clinical neurology and neuroscience to undergraduate and graduate students.
Outline of Clinical and Research Activities:
137
1. Neurodegenerative diseases: Diagnosis and treatment of
neurodegenerative diseases. Studies on pathomechanism
and new treatments for Alzheimer's disease, Parkinson's
disease, amyotrophic lateral sclerosis and spinocerebellar
atrophy.
2. Cerebrovascular diseases: Diagnosis and treatment of cerebrovascular diseases. Studies on neuropsychology, PET and
MRI.
3. Clinical electrophysiology: Evaluation and treatment of patients with medically intractable epilepsy, movement disorders such as focal dystonia and myoclonus, various neuromuscular diseases and sleep disorders.
4. Neuroimmunology: Studies on etiology and pathomechanism of neuroimmunological diseases.
Professor:
TAKAHASHI, Ryosuke, M.D., D.Med. Sc. (Kyoto Univ.),
Neurodegenerative diseases, Parkinson's disease, ALS, Molecular neurobiology;
IKEDA, Akio, M.D., D.Med.Sc. (Kyoto Univ.), Epilepsy, electroencephalography and clinical neurophysiology, Movement
disorders;
Senior Lecturer:
ITOH, Hidefumi, M.D., D.Med.Sc. (Kyoto Univ.), Clinical
neuropathology, Parkinson’s disease, Deep brain stimulation;
INOUE, Haruhisa, M.D., D.Med.Sc. (Kyoto Univ.), Neurodegenerative diseases, Regenerative Medicine, Molecular neurobiology;
KAWAMATA, Jun, M.D., D.Med.Sc. (Kyoto Univ.), Neurodegenerative diseases, Alzheimer's disease, ALS, Gene analysis,
Molecular biology;
MATSUMOTO, Riki, M.D., D.Med.Sc. (Kyoto Univ.), Epilepsy,
Clinical neurophysiology, Neuroimaging;
IHARA, Masafumi, M.D., D.Med.Sc. (Kyoto Univ.), Cerebrovascular diseases, Geriatric neurology, Neurodegenerative
diseases;
DEPARTMENT OF NEUROSURGERY
Now and Then:
The First Division of the Department of Surgery has long
been acknowledged as one of the few major neurosurgical
centers in Japan, mainly due to the pioneering and enduring
efforts of the late Emeritus Professor, Dr. Chisato Araki. In
1965 the Department of Neurosurgery was established as an
independent department to be devoted to the surgery of the
nervous system. Dr. Hajime Handa became the first Professor of the Department of Neurosurgery in 1965. During the
following 20 years, the Department of Neurosurgery developed so steadily as to play a leading role in the neurosurgical
field in Japan. Dr. Haruhiko Kikuchi succeeded to the Department as the second Professor in 1986. He is one of the
pioneers of microneurosurgery with great efforts to make the
technique popular in Japan. As described above, this Department has been managed by these great authorities in Japan
Neurosurgical Society. Succeeding to the history, Dr. Nobuo
Hashimoto was elected as the new chairman of this Department in 1997.
As 2008, the Department staff consists of 34 faculty members including 10 staff members, 4 clinical fellows and 20
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graduate students. Daily clinical practice is being conducted
in the 53-bed ward and in the outpatient clinic with more than
12,000 patient visits per year. The number of operative cases
is around 500 every year including the cases of endovascular
surgery and X-knife surgery.
Clinical Activities:
We especially deal with difficult cases of cerebrovascular
disease and brain tumors, which require highly advanced microsurgical techniques along with endovascular surgery and
intraoperative angiography. In co-operation with the Human
Brain Research Center and the Department of Neurology, we
are developing awake-surgery, mapping and monitoring of
brain functions, which enable us to remove lesions even in the
eloquent areas by making sure the function remains intact. We
not only excise brain tumors, but also apply advanced chemotherapy and radiotherapy including X-knife. Utilizing
these multiple modalities, we have achieved good outcomes.
In the field of obstructive cerebrovascular disease, we are
taking a leading role in a nation-wide clinical trial for vascular
reconstruction.
We are a pioneer in generating animal models of cerebral
aneurysms, and have been investigating the pathogenesis and
genetics of aneurysms by analyzing familial cases. We are
developing a method for brain protection by investigating the
molecular mechanisms of brain death after ischemic insult.
For brain tumors, we generate detailed molecular profiles of
each tumor so that we can apply the optimal treatment for
each individual tumor. Other research projects include investigation of the pathogenesis of epileptic focus, development of
artificial dura mater, new bio-bond, and coils to obliterate aneurysms. We are also promoting studies for regenerative
medicine such as vascular regeneration by endothelial precursors, neuronal regeneration by neural stem cells and embryonic stem cells, and bony regeneration.
Education:
Almost all of the doctors receive a degree and become authorized specialists in neurosurgery. After that, the door for
study abroad is open.
Publication:
1. Hashimoto N, Nozaki K, Takagi Y, Kikuta K, Mikkuni N.,
Surgery of Cerebral Arteriovenous Malformations. Neurosurgery 61(1): 375-389, 2007
2. Mikuni N, Okada T, Nishida N, Taki J, Enatsu R, Ikeda A,
Miki Y, Hanakawa T, Fukuyama H, Hashimoto N., Comparison between motor evoked potential recording and fiber tracking for estimating pyramidal tracts near brain
tumors. J Neurosurg. 106(1): 128-33, 2007
3. Kikuta K, Takagi Y, Nozaki K, Miyamoto S, Kataoka H,
Arai T, Hashimoto N ., Effects of intravenous anesthesia
with propofol on regional cortical blood flow and intracranial pressure in surgery for moyamoya disease.Surg Neurol.
68(4): 421-4, 2007
4. Takagi Y, Kikuta K, Nozaki K, Sawamura K, Hashimoto N.
Detection of a residual nidus by surgical microscope-integrated intraoperative near-infrared indocyanine
green video angiography in a child with a cerebral arteriovenous malformation. J Neurosurg.
107(5):416-418,2007
MIKUNI, Nobuhiro, M.D., D.Med.Sc. (Kyoto Univ.), 1. Epilepsy; 2. Functional mapping & monitoring;
Senior Lecturers:
KIKUTA, Kenichiro, M.D., D.Med.Sc. (Kyoto Univ.), Cerebrovascular disease;
TAKAGI, Yasushi, M.D., D.Med.Sc. (Kyoto Univ.), Cerebrovascular disease;
HOJO, Masato, M.D., D.Med.Sc. (Kyoto Univ.), 1. Brain tumors; 2. Neuroendocrinology;
KISHI, Yo, M.D., D.Med.Sc. (Kyoto Univ.), 1. Brain tumors;
2. Functional neurosurgery; 3. Neuronal regeneration;
NISHIMURA, Masaki, M.D., D.Med.Sc. (Kyoto Univ.), Cerebrovascular disease;
ARAKAWA, Yoshiki, M.D., D.Med.Sc. (Kyoto Univ.), Brain
tumors;
ISHII, Akira, M.D., D.Med.Sc. (Kyoto Univ.), Cerebrovascular disease, endovascular surgery;
SHIRAHATA, Mitsuaki, M.D., D.Med.Sc. (Kyoto Univ.), Brain
tumors;
DEPARTMENT OF PSYCHIATRY
This Department was founded in 1904. The first Professor
Shinkichi Imamura (1904-1934), known as a pioneer in clinical psychopathology as well as neuropsychiatry in Japan, laid
the foundation of this Department's tradition attaching much
importance to "clinical" psychiatry. The second Professor
Momoshige Miura (1935-1952) succeeded to Imamura's academic features, led many researchers, e.g. Masashi Murakami
(psychopathology), Hisatoshi Mitsuda (clinical genetics),
Seishiro Kuromaru (child psychiatry), Juhichi Okamoto (epileptology), Noboru Hatotani (psychoendocrinology), Hiroshi
Ohashi (neuropsychology) in various fields of psychiatry. The
third Professor Masashi Murakami (1953-1973) was an eminent psychopathologist, so that this Department was the most
prominent research center for clinical psychopathology in Japan. Subsequently, Professor Hiroshi Ohashi (1973-1985),
Professor Bin Kimura (1986-1994, anthropological psychopathology) and Koho Miyoshi (1995-1999, neuropsychiatry)
succeeded to this Department one after another. In 1995, the
Department of Psychiatry had divided into three Departments,
namely Psychological Medicine, Neuropsychiatry and Forensic Psychiatry. However, in 2001 the former two Departments
merged into the Department of Psychiatry, and the seventh
Professor Takuji Hayashi (clinical psychiatry) was elected in
2001. He is investigating the biological bases of schizophrenic psychoses, among others, atypical psychoses using
brain imaging and psychophysiological techniques.
The Department staff consists of 35 faculty members including 12 staff members, 5 residents and 18 graduate students. Daily clinical practice is being conducted in the 60-bed
ward and in the outpatient clinic of more than 120 patients per
day.
The Department is responsible for teaching clinical psychiatry and related neuroscience to undergraduate and graduate students.
Medicine
The main subjects of research are as follows:
1. Clinical psychopathology of endogenous psychoses.
2. Brain imaging and neurophysiological studies of endogenous
psychoses.
3. Brain imaging and neurophysiological studies of epilepsy.
4. Neuropsychological studies of autism.
5. Biochemical studies of eating disorders.
6. Psychoanalysis of personality disorders.
7. Transcultural psychiatry.
Professor:
HAYASHI, Takuji, M.D., D.Med.Sc. (Aichi Med. Univ.),
Clinical psychopathology and neuroradiology of atypical
psychoses;
MURAI, Toshiya, M.D., D.Med.Sc. (Kyoto Univ.), Neuropsychiatry;
Senior Lecturers:
NOMA, Shun'ichi, M.D., D.Med.Sc. (Kyoto Univ.), Clinical
psychopathology of eating disorders and consultation liaison
psychiatry;
YOSHIOKA, Ryuichi, M.D., Forensic Psychiatry;
OKADA, Takashi, M.D., Child and Adolescent Psychiatry;
FUKAO, Kenjiro, M.D., Epileptology and Clinical Neurophysiology;
NAMIKI, Chihiro, MD., D.Med.Sc. (Kyoto Univ.), Psychogeriatrics;
OSHITA, Akira, M.D., Forensic Psychiatry;
KATSUKI, Akira, M.D., Clinical Psychopathology and Consultation Liaison Psychiatry;
SUWA, Taro, M.D., Clinical Psychopathology;
NISHI, Naoki, M.D., Clinical Psychotherapy;
YAMASAKI, Nobuyuki, M.D., Clinical Psychopathology;
EPIDEMIOLOGY AND BIOSTATISTICS
The fields put primary focus on the development in and
teaching methodologies used for health research and practice.
In order to improve public health and the therapeutic outcome
of treatments, the four departments, Biostatistics, Epidemiology & Healthcare Research, Pharmacoepidemiology, and
Genome Epidemiology are devoted to develop new epidemiological methodologies, to carry out the analysis of the quality
of life and the outcomes for important difficult disorders, and
to support developing new treatments, from the aspects of design and analysis for clinical trials, epidemiological studies,
and outcomes research. Staff members are responsible for
teaching those disciplines for graduate students.
DEPARTMENT OF BIOSTATISTICS
http://www.pbh.med.kyoto-u.ac.jp/english/html/dep1a.html
The Department of Biostatistics was established in 2000.
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Graduate students interested in the methods of biostatistics
and the conduct of epidemiologic research and clinical trials
are welcomed.
This Department offers programs of study leading to a
master's degree and a doctoral degree. The Master of Public
Health (MPH) degree program is designed to provide basic
training in biostatistics as applied to a broad spectrum of
health-related problems. The doctoral degree program is designed to provide advanced, research oriented training in
methods of biostatistics.
Major research fields are biostatistics methodology and
the conduct of epidemiologic studies and clinical trails. In
methodological work, new epidemiologic study designs
which are efficient and convenient are investigated for providing new sampling and analysis methods. Causal inference
is the most challenging methodological research field. Estimation of causal parameters in experimental and observational studies is developing. Several collaborative studies in
epidemiology and clinical trials are ongoing.
Professor:
SATO, Tosiya, D. Health Sc. (Univ. of Tokyo), 1. Epidemiologic methods; 2. Causal inference; 3. Collaborative studies
in epidemiology and clinical trials
OHMORI, Takashi, D. Eng. (Tokyo Univ. of Sci.), 1. Biopharmaceutical statistics; 2. Alternative methods to Animal experiments; 3. Pharmacoepidemiology
DEPARTMENT OF EPIDEMIOLOGY
AND HEALTHCARE RESEARCH
Education:
The department's primary educational goal is to train
graduate students in the basic concepts and methods of epidemiology and healthcare research, and thereby to prepare
them for work in health-related fields. Three lecture courses
and practicum will be offered; Epidemiology, Study Design,
Designing Survey Research and Health Services Research.
From Spring of 2005, a new Master program, Master of
Clinical Research (MCR) was started and this department
contributes to this program with new 5 course works (Protocol Development and Management, Clinical Biostatistics,
Data Analysis, Decision Analysis, Medical Writing). Faculty
members in the department also supervise doctoral students
conducting original research.
Research:
Faculty and graduate students conduct observational and
experimental studies both of patients and of populations. In
general, those studies are of three types:
1. Clinical effectiveness research, in which the effectiveness
of existing, and newly developed methods of diagnosis
and therapy are assessed, often with the use of patient-based outcomes, such as health-related quality of
life.
2. Methodological research, in which the methods used to
measure and analyze health status and health outcomes
(including health-related quality of life), those measurements are analyzed and interpreted for their clinical and
social relevance.
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3. Health Services Research, which studies methods to measure, and scientifically assesses strategies to improve quality of healthcare.
Professor:
FUKUHARA, Shunichi, M.D., M.Sc. (Harvard Univ.),
D.Med.Sc. (Univ. of Tokyo), 1. Clinical epidemiology; 2.
Outcomes research; 3. Health services research; 4.
Health-related quality of life
YAMAZAKI, Shin, M.P.H., D., Ph.D. (Kyoto Univ.), 1. Environmental epidemiology; 2. Health related quality of life;
HAYASHINO, Yasuaki, M.D., Ph.D. (Kyoto Univ.) 1.Clinical
epidemiology; 2. Decision analysis; 3. Behavioral science
TAKEGAMI, Misa, R.N., M.P.H. (Kyoto Univ.),
1. Clinical epidemiology; 2. Outcomes research;
DEPARTMENT OF PHARMACOEPIDEMIOLOGY
Phone: +81-75-753-9769; Fax: +81-75-753-4469
URL: http://square.umin.ac.jp/kupe/
The Department of Pharmacoepidemiology was newly
established in 2000 as the first official department for application and education in this field in Japan.
Pharmacoepidemiology is a natural crossing of scientific
paths. Epidemiology is the study of disease occurrence, and
Pharmacology aims to reduce disease incidence and prevalence through biochemical interventions. Pharmacoepidemiology can be defined as the application of epidemiologic
reasoning, methods, and knowledge to the study of the uses
and effects (beneficial and adverse) of drugs in human populations including clinical trials.
The efficacy and safety of the drug and biologics are
evaluated through the drug development process involving
preclinical and clinical studies and post-marketing surveillance. The differences in the regulatory systems among Japan,
US, EU, and Asian countries in terms of healthcare, science,
and industry will be discussed.
Current research activities are mainly focused on the
clinical application of pharmacoepidemiologic methodologies.
Individual research subject undertaken include:
1. Assessment on safety and effectiveness of drug and biologics and the research on clinical trial and drug approval
systems by the regulatory agencies.
2. Research and development of targeted cancer therapeutics
including immunotoxin/cytotoxins and cancer vaccines.
3. Research on the infrastructure of drug development using
novel biotechnology and public acceptance of translational research.
4. Biostatistics on the clinical trials and clinical researches
and pharmacogenomics research.
Professor:
KAWAKAMI, Koji, M.D. (Tsukuba Univ.), D.Med.Sc. (Yokohama City Univ.),
1.Regulatory science; 2.Anticancer molecular therapeutics
and biologics;
HINOTSU, Shiro, M.D. (Tsukuda Univ.), D.Med.Sc (Tsukuba
Univ.)
1 Design and analysis of clinical trials; 2. Urology;
Assistant Professors (Special Appointment):
KOHNO, Masayuki, D.Med.Sc. (Chiba Univ.), Molecular biology;
HORIBE, Tomohisa, D.Med.Sc. (Ritsumeikan Univ.), Molecular biology;
URUSHIHARA, Hisashi, D.Health.Sc. (Kyoto Univ.), Epidemiology, drug safety;
DEPARTMENT OF GENOME EPIDEMIOLOGY
Professor:
MATSUDA, Fumihiko, D.Med.Sc (Kyoto Univ.), 1. Molecular
biology; 2. Human genetics;
For details, see Center for Genomic Medicine.
HEALTH ADMINISTRATION
This field deals with the policy making and administration
in public health and health care in the context of ethical, economic and informational theories.
DEPARTMENT OF HEALTHCARE ECONOMICS
AND QUALITY MANAGEMENT
Phone +81-75-753-4454, Fax +81-75-753-4455
http://med-econ.umin.ac.jp/
The Department aims to contribute to the improvement of
the quality and efficiency of health care systems by means of
research, development, education and any other relevant professional activities. To tackle and solve problems of quality
and cost in health and health care, the Department applies
multi- and inter-disciplinary fields of quantitative and qualitative sciences and technologies. The uniqueness of the Department is that we develop "soft" technologies for actual use
in health care management and policy.
The training and education aims to nurture highly professional experts and their network in this emerging field of
healthcare quality, economics, management and policy. The
Department also provides training for executives and young
leaders in health care management. The Department stresses
the interaction of “research and development” with
“real-world systems and policies”, with one of the goals to
produce outputs for resource- and quality-based healthcare
financing system together with effective management system
and policy.
The research themes are: (1) Evaluation of quality, cost and
efficiency of health care, including clinical performance,
practice variation, technology transition, economic evaluation, technology assessment and information infrastructures
for health, patient casemix classification, financial performance and costing systems; (2) Payment, reimbursement and
insurance in health care and its related systems; (3) Management system in health care, including healthcare accreditation,
management quality, organizational and financial management,
safety and risk management, satisfaction and organizational
culture. (4) Population-based assessment of health status,
Medicine
health-related resource consumption, demand and supply, and
effects of interventions and system changes. (5) Analysis and
planning of health care systems, policies and their performance, including projects granted by national/local governments and international agencies.
Professor:
IMANAKA, Yuichi, M.D., D.Med.Sc. (Univ. of Tokyo), M.P.H.
(Univ. of Michigan), Ph.D. (Univ. of Michigan), 1. Quality,
cost and performance of health care and its systems; 2. Management, policy and economics in health care;
Senior Lecturers:
SEKIMOTO, Miho, M.D. (Kyoto Pref. Med. Sch.), D.Med.Sc.
(Kyoto Univ.), M.P.H.(Johns Hopkins Univ.), Quality of care;
HAYASHIDA, Kenshi, M.Sc. (Tokyo University), Ph.D. (Kyoto
University), Healthcare Economics and Management;
Hiroshi, M.D. (Kyoto University), Healthcare Economics;
IKAI,
DEPARTMENT OF BIOMEDICAL ETHICS
The objectives of the courses that we offer are to enable
students to gain an understanding of ethical issues in health
care; familiarity with the major ethical approaches to, and
philosophical reasoning, regarding moral decisions in the field
of public health and clinical medicine; the ability to think
critically about key issues in some of the most controversial
areas of biomedical ethics; and the skills to design and implement one's own research project.
The courses, led by two full-time faculty members as well
as several visiting lecturers will consist of lectures, small
group discussion, and presentations by students of their research projects. On completion of the course, each student is
expected to be able to recognize, analyze ethical arguments,
and reach ethically sound decisions on their own. They are
also expected to have acquired the abilities to bring a theoretical framework to the analysis and the evaluation of ethical
issues in health care.
search including genome approach, quantitative and qualitative assessment of health-related information e-Health; and
information ethics.
Professor:
NAKAYAMA, Takeo, M.D., D.Med.Sc. (Tokyo Medical and
Dental Univ.), 1. Health informatics; 2.Evidence-based
healthcare; 3. Epidemiology;
DEPARTMENT OF MANAGEMENT OF TECHNOLOGY AND INTELLECTUAL PROPERTY
Phone +81-75-753-9332, Fax +71-75-753-9333
Along with paradigm change taking place on global scale,
the universities are being counted upon by the public on their
capability in handling these changes. Under much expectations from both industry and government sector, universities
now have a role to contribute to society by leading the development of advanced scientific technologies from basic research to industrially applicable form.
The department aims to foster directors of intellectual
property, a human resource essential in utilizing university’s
intellectual properties.
As well as equipping students with practical skills, department teaches both basic theories in medicine particularly in
the field of advanced medicine, and in humanities and social
science, particularly on the exploitation of intellectual property rights. The department aims to nurture directors of
technology management, the personnel with the capability to
discover, manage and exploit the intellectual property in the
field of biotechnology, particularly in advanced medicine.
1.
2.
Professor:
KOSUGI, Shinji, M.D., D.Med.Sc. (Kyoto Univ.), 1. Biomedical ethics; 2. Clinical ethics; 3. Clinical Genetics;
NUMABE, Hironao, M.D., D.Med.Sc. (Tokyo Medical Univ.),
1. Biomedical ethics; 2. Clinical ethics; 3. Clinical Genetics;
3.
DEPARTMENT OF HEALTH INFORMATICS
In today’s society, the impact of health-related information
on human behavior and health can be just as profound as, or
in some cases, more profound than, the impact of physical
environment on human health. This field of study explores
how information can contribute to improve people’s health
behavior/health-care-seeking behavior, and decision-making
in both clinical setting and public health. The main topics to
be covered are: Evidence-based healthcare (EBHC); decision
analysis, health literacy & communication; epidemiologic re-
141
Natural Science: the course will give students
top-level scientific knowledge and the knowledge on industrial demand through lectures by
the academics who are engaged in researches of
forefront science at the graduate school of medicine, and by the industrial professionals who
hold abundant experience in translational research and development research in the industry.
Humanities and other Subject in School of Public Health: the department will give students basic knowledge of intellectual property laws and
other social sciences through lectures by instructors selected for each specialization field.
The practical skills and knowledge in accounting
and market valuation and distribution of intellectual property (venture capital field) are taught
through lectures by lecturer with a long career in
business.
Practical Skills: Using the knowledge learned
above as a base, the course will equip students
with ability to act in real life situation through
work experience at Kyoto University and
through other externships, gaining experience in
establishing rights in research out come and in
exploitation of those rights.
At the Management of Technology and Intellectual Property, researches are being conducted on various problems
faced in management and practical application of intellectual
property rights. So far, research has been conducted on “In-
142
vestigation for protection and utilization of intellectual property in translational research for purpose of establishing the
management system” and “Systems of intellectual property
management which can accommodate movement of researchers from one institution to another”. The findings from these
researches are reflected in the management of intellectual
property at the university.
Professor:
TERANISHI, Yutaka, D.Eng. (Kyoto Univ.), 1. Molecular Biology; 2. Management of Technology;
ABE, Seiji, M. Agr. (Tohoku Univ.),
SAOTOME, Chikako, D.Pharm.Sci. (Toho Univ.), 1. Management of Intellectual Property,
DEPARTMENT OF MEDICAL COMMUNICATION
Phone +81-75-753-4668
Medical Communication is a specialized area in medicine
within science communication, which is currently enjoying
national and international public attention. Kyoto University
is the first in Japan to have established a department of Medical Communication in April, 2008 that investigates how
medical knowledge is shared and circulated among different
societal segments (eg., the public, media, policy makers, and
the medical community) on a variety of levels (personal/micro,
community/meso, social/macro, and international). The field
of medical communication also explores how medicine communicates with society. Medical communication, therefore, is
not the same as health communication, which is a well-known
communication field researching a doctor-patient interaction,
as the former has a more macro research domain. This new
department welcomes students who are eager to not only
tackle the aforementioned ambitious theme but also explore
and claim the emerging field of medical communication.
First semester: In this semester, the course provides an introduction to medical communication, both its theoretical
frameworks and applications, for those from diverse interests,
backgrounds, and/or disciplines. In class, frames from communication studies, disability studies, and/or science communication are drawn, and an issue of communication channels
is addressed. Second semester: Building upon the first semester, the course further explores current topics in medical
communication, especially relations among the medical/research community, media, public, and policy makers.
IWAKUMA, Miho, Ph.D. (University of Oklahoma),
1. (Intercultural) communication; 2. Disability studies; 3.
Aging with disability
occupational and environmental health. The research goal is
approached by versatile methodologies mainly, genetic epidemiology and molecular toxicology. This department provides courses of occupational and environmental health to
medical students and M.P.H. master students. For Ph. D. students we offer research courses for occupational and environmental health with emphasis on genetic factors and toxicology. The major fields of research include genetic epidemiology for cerebrovascular diseases and toxicology of persistent organic pollutants.
Professor:
KOIZUMI, Akio, M.D., D.Med.Sc. (Tohoku Univ.), Genetic
epidemiology, occupational health and environmental sciences;
Senior Lecturer:
HARADA, Kouji, MPH, Dr.PH.Ph.D. (Kyoto Univ.), Environmental health sciences;
MINATA, Mutsuko, M.D., D.Med.Sc. (Kyoto Univ.), Toxicology;
HITOMI, Toshiaki, M.D., D.Med.Sc. (Kyoto Prefectual Univ.),
Genetic epidemiology, occupational health and environmental
sciences;
DEPARTMENT OF HEALTH PROMOTION
AND HUMAN BEHAVIOR
The department offers lectures on the effect of lifestyles in
the development of chronic disorders including cardiovascular,
diabetes, obesity, allergies, and cancers. The department also
offers lectures on human behavior given by part-time lectures
how to educate populations with high risks to give up their
bad lifestyles.
The department is collaborating with more than 30 research groups world-wide, and it enables students to involve
ongoing international projects, which will assist them in writing high-quality academic papers.
Professor:
KOSUGI, Shinji, M.D., D.Med.Sc. (Kyoto Univ.), 1. Biomedical ethics; 2.Clinical ethics; 3.Clinical genetics;
YAMASAKI, Akiko, D.Med.Sc. (Univ. of Tokyo), Social epidemiology.
INTERNATIONAL HEALTH
This program prepares health professionals for expected
roles in international agencies and in collaborative overseas
projects.
HEALTH DETERMINANTS
This field encompasses the disciplines related to exploring
the determinants of health, i.e., environmental factors and individual as well as population behavioral factors.
DEPARTMENT OF GLOBAL HEALTH
AND SOCIO-EPIDEMIOLOGY
DEPARTMENT OF HEALTH AND
ENVIRONMENTAL SCIENCES
Our department was established in April, 2000 in Kyoto
University School of Public Health. Our department adopts
a new discipline of social medicine which takes multifaceted
approach that encompasses both medical and social sciences,
This department was established in 2000. The primary research and teaching endeavor is to provide scientific bases for
Phone +81-75-753-4350
Fax +81-75-753-4359
Medicine
or quantitative and qualitative research methods. We call
this
interdisciplinary approach ‘socio-epidemiology’.
Socio-epidemiology aims to restore the views and methodologies which biomedical science, that is epistemologically
grounded in the tradition of logical positivism, has been lacking and attempts to improve the health of people on the basis
of not only biomedical evidence but also on socio-cultural
understanding of health, utilizing systematic social programming approach.
Our research interest is exclusively focused on
socio-epidemiological approach to HIV prevention in Japan as
well as overseas based on quantitative and qualitative methods,
behavioral theories, social marketing approach and social experimental methods. As principal investigators of multiple
national HIV-related research groups, we have been involved
in the behavioral and preventive studies on youth, immigrants
and other various vulnerable subpopulations. International
collaborative researches involve a bio-behavioral and preventive studies among drug users in Iran in collaboration with the
Ministry of Health of Iran and UNDP/UNODC (2003-), and
large-scale behavioral and preventive studies among university students in Zhejiang Province of China (2003-). In 2006,
our department was appointed as a UNAIDS Collaborating
Centre aiming at expansion of socio-epidemiological studies
on HIV.
In the first term, students will learn about the study design
issues relevant to socio-epidemiology such as social marketing, non-probability sampling, social experimental design, social research methods and practical questionnaire development. To master socio-epidemiology, a series of lectures and
workshops are held on qualitative research methods in the
second term that are basic to socio-epidemiology such as
in-depth interviews, focus group interviews, and qualitative
data analysis. Throughout these courses students are expected to acquire an integrated view on socio-epidemiology
and lay a solid foundation for the future research.
Professor:
KIHARA, Masahiro, M.D., D.Med.Sc. (Kyoto Univ.),
1. Socio-epidemiology; 2. HIV prevention;
ONO-KIHARA, Masako, M.Sc., D.Med.Sc. (Yokohama City
Univ.), 1. Socio-epidemiology; 2.Molecular epidemiology;
3.HIV prevention; 4.Behavior epidemiology;
ZAMANI, Saman, M.D., Ph.D. (Kyoto Univ.),
1. Socio-epidemiology; 2. HIV prevention; 3 Reduction of
drug-related harm;
DEPARTMENT OF PUBLIC HEALTH AND
INTERNATIONAL HEALTH
The Department of Public Health and International Health
was established in 1949 as the Department of Public Health,
within the Faculty of Medicine. The Department was
chaired successively by Professor Masashichi Nishio
(1949-1973; medical care and welfare, toxicology of heavy
143
metals and organic solvents), Professor Seiyo Sano
(1973-1987; lead poisoning, porphyrin and heme biosynthesis)
and Professor Masayuki Ikeda (1988-1996; occupational and
environmental health, organic solvent poisoning and predictive toxicology). Dr Toshitaka Nakahara was appointed as
Professor and Chairman of the Department in 1997.
At the time of the establishment of the School of Public
Health in April 2000, the Department of Public Health became the Department of Public Health and Administration,
which afresh became the Department of Public Health and
International Health in May 2003. The Department is currently responsible for the courses offered to undergraduate
students in medicine, graduate students in social medicine as
well as graduate students enrolled in the School of Public
Health.
Professor:
NAKAHARA, Toshitaka, M.D., D.Med.Sc. (Nihon Univ.),
M.P.H. (Johns Hopkins Univ.), 1. Health policy and management; 2. International health;
SATOMURA, Kazunari, M.D., D. Med. Sc. (Kyoto Univ.),
1. Health education and promotion; 2. International health; 3.
Food safety;
IWANAGA, Suketaka, M.D., 1. Health education and promotion; 2. Health information; 3. International health;
SCHOOL OF HUMAN HEALTH SCIENCES,
FACULTY OF MEDICINE
Head of School: SASADA, Masataka, M.D., D.Med.Sc.
(Kyoto Univ.)
53, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, JAPAN
Tel: +81-75-751-3901
Fax: +81-75-751-3909
http://www.hs.med.kyoto-u.ac.jp/
DEPARTMENT OF NURSING
Nursing is the practical science which supports the people
of all healthy level of individual, family and community.
The Department of Nursing was established in 2003, but the
precursor goes back until 1989. This department has the responsibility for the education of registered nurse, public
health nurse and nurse midwife, and the researches in the
nursing study area. There are four areas, ‘Basic Nursing
Science’, ‘Clinical Nursing Science’, ‘Family Nursing Science’ and ‘Community Health Nursing Science and
Gerontological Nursing Science’ in this department.
Basic Nursing Science is the fundamental area of nursing
education. This area composed of Nursing theory, Environmental Health Nursing, Basic Nursing Techniques, and so on.
This area aims to inspect for evidence of nursing practice and
to develop the various method of evaluating the nursing techniques.
Clinical Nursing Science is composed chronic and critical
adult nursing and psychiatric nursing. The education and
research of chronic and critical adult nursing are focused on
pre-post operative and transplant care, psycho-social care, patient’s education and to development of nursing knowledge
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and skill to maintain and promote for patient’s health.
The
psychiatric nursing is emphasized in psychiatric and health
care and mental and physical rehabilitation care for both patients and their family to live at community.
Family Nursing Science is composed of pediatric nursing,
women’s health, maternity nursing and midwifery. The family nursing science is focused on sound growth and development of children, the safe and comfortable birth, and reproductive health/rights of women and so on, in order to keep
and to promote physical, mental and social health of family
members.
Community Health Nursing Science covers diverse subjects
such as introduction to community health nursing, community
health assessment, community health nursing, and some other
subjects, in particular, in order to provide curriculum for public health nurses. Gerontological Nursing Science covers
diverse subjects such as gerontological nursing, home care
nursing and community care system in order to provide curriculum for home care nurses.
Basic Nursing Science
Professors:
MIYAJIMA, Asako, R.N., P.H.N., Ph.D., (Nara Women’s
Univ.), 1. Environmental health nursing; 2. Studies of living
environment for client/patient; 3. Consultation about living
environment for home care patients; 4. Development of sign
communication system in hospital and ward; 5. Nursing theory; 6. Basic nursing techniques;
SUGA, Sawako, D.Ed. (Kyoto Univ.), Clinical psychology;
WAKAMURA, Tomoko, R.N., P.H.N., Ph.D. (Nara Women’s
Univ.), 1. Basic nursing techniques; 2. Sleep managements
(Chronobiology, thermal and clothing physiology in sleep,
sleep Environment, QOL of sleep disorder patients);
SUZUKI, Kazuyo, R.N., P.H.N., M.A., 1. Nursing in society;
2. Basic nursing techniques;
Clinical Nursing Science
Professors:
EGAWA, Takako, R.N., M.S.N., Ph.D. (Osaka Univ.), 1. Area
for education and research is self-care and foot care of diabetes and self-care of patient with dialysis treatment; 2.
Clinical nursing for adults;
HOSODA, Kiminori, M.D., Ph.D. (Kyoto Univ.), 1. Endocrinology and Metabolism; 2. Diabetes Mellitus; 3. Obesity; 4.
Molecular Medicine; 5. Internal Medicine;
HAYASHI, Yuko, R.N., P.H.N., M.S.N., Ph.D. (St.Luke’s College of Nursing), 1. Adult health nursing; 2. Transplantation
nursing;
NOMOTO, Shinichi, M.D., Ph.D. (Kyoto Univ.),
1. Cardiovascular Surgery; 2. Critical care medicine;
SAITO, Yumi, R.N., M.S.N., Ph.D. (Jichi Med. School),
1. Hospital infection control; 2. Infection control nursing; 3.
Immuno-psycho-oncology nursing; 4. Nursing theory 5. Basic
nursing techniques;
S AKURABA, Shigeru, R.N., Ph.D. (Yamagata Univ.), 1.
Patients with mental illness Care; 2. Psychiatric and mental
health nursing; 3. Mental health; 4. Patient advice and liaison service; 5. Alexithymia; 6. Suicide; 7. Psychopharmacol-
ogy; 8. Social welfare services;
AKAZAWA, Chiharu, R.N., M.S.N., Ph.D. (Kyoto Univ.),
1. Clinical nursing for adults; 2. Critical care; 3. Trans-plantation
nursing care; 4. Stress-coping;
HONDA, Ikumi, R.N., C.N.M., Ph.D. (Osaka Univ.),
1. Clinical nursing for adult with diabetes; 2. Foot care for the
adult and the elderly; 3. Health behavior and health education;
SAKUDA, Hiromi, R.N., P.H.N., Ph.D. (Hiroshima Univ.),
1. Cancer nursing; 2. Lymphedema care; 3. Nursing technical
education methodology;
SUMIKA, Masuko, R.N., P.H.N., M.S.N., Ph.D. (Osaka
Univ.), 1. Practicum in adult nursing;
TAKAHASHI, Miwa, R.N., P.H.N., M.S., 1. Practicum in fundamental nursing;
KONISHI, Nami, R.N., P.H.N., Ph.D., (Yamanashi Univ.),
1. Practicum in mental health nursing;
Teaching Associate:
FUKUDA, Risa, R.N., P.H.N., M.P.H., 1. Practicum in adult
nursing;
Family Nursing Science
Professors:
KABEYAMA, Kiyoko, R.N., R.M., M.S.N., Ph.D. (Nara
Women’s Univ.), 1. Midwifery; 2. Maternal and child health
nursing; 3.Women’s health; 4. Human sexuality;
SUGANUMA, Nobuhiko, M.D., Ph.D., 1. Obstetrics and gynecology; 2. Reproductive medicine; 3. Assisted reproductive
technology; 4. Hormonal disorders;
YAGI, Keiko, R.N., N.M., P.H.N., M.N.S., 1. Midwifery; 2.
Maternal and child health nursing; 3. Women's health nursing;
TANIGUCHI, Hatsumi, R.N., R.M., M.P.H., M.S.N.,
Ph.D.(Univ. of Hawaii at Manoa), 1. Women’s health; 2. Midwifery; 3. Maternal and child health;
Senior Lecturer:
WATANABE, Hiroko, R.N., R.M., M.S.N., M.H.S.,
Ph.D.(Tokyo Univ.), 1. Midwifery; 2. Maternal and child
health nursing;
CHIBA, Yoko, R.N., R.M., M.P.H. (Boston Univ.), 1. Practicum in midwifery ; 2. Practicum in maternal and child health
nursing;
KIYOKAWA, Kanako, R.N., P.H.N., M.S.N., 1. Practicum in
pediatric nursing;
YAMAGUCHI, Kotomi, R.N., R.M., P.H.N., M.S.N., 1. Practicum in maternal and child health nursing; 2. Midwifery;
Community Health Nursing Science and Gerontological
Nursing Science
Professors:
KATSURA, Toshiki, R.N., P.H.N., Ph.D. (Yamagata Univ.), 1.
Medicine
Lifestyle and metabolic syndrome; 2. Visual information
processing relating to falls in elderly; 3. Successful aging 4.
Cardiovascular disease prevention;
KINOSHITA, Ayae, M.D., D.Med.Sci. (Kyoto Univ.), 1. Neurology, Internal medicine; 2. Alzheimer’s disease and related
disorders; 3. Gerontological nursing;
HOSHINO, Akiko, R.N., P.H.N., Ph.D. (Tohoku Gakuin Univ.),
1. Community organization; 2. Health behavior; 3. Health
promotion; 4. Community health care system;
USUI, Kanae, R.N., P.H.N., M.Health Sci. (Osaka Univ.),
1. Community health care system; 2. Supporting techniques of
public health nurse;
KUBOTA, Masakazu, R.N., P.H.N., M.Med.Sci., Ph.D. (Nagoya Univ.),
1. Alzheimer’s disease and related disorders; 2. Gerontological nursing; 3. Dementia care system;
DEPARTMENT OF LABORATORY SCIENCE
Department of laboratory science has three courses as
shown below. The outline of those courses is presented as
follows.
Analysis of basic pathological information on organisms:
In the course, you will extract information from the genetic
and molecular levels of organisms to the cellular and organic
levels of animal body, and analyze the information from a
wide variety of angles. As the basis for it, you will profoundly learn the functions and pathological conditions of the
organisms concerned. You will thus equip yourself with the
power of observation and thinking, as well as creativity for
the analysis.
Analysis of clinical pathological information on organisms:
In the course, you will learn how to apply the information
obtained from organisms to clinical diagnosis and therapy.
You will also learn the fundamental theory and technology of
advanced medical treatment, in order to contribute particularly to the promotion and establishment of implantation, reproduction, and genetic treatment. At the same time you
will equip yourself with the ability to positively overcome
various clinical problems.
Engineering of advanced information technologies for medicine:
This course is consisted of the following three groups:
Medical Informatics group, Medical Devices for Diagnosis
group, and Innovative Medical Imaging Technology group. In
the course, you will learn information technologies for clinical diagnosis from their basic principles to their applications.
Main target of the course is the sensing, imaging, and image
processing technologies. Further, you can engage in the researches for developments of new hardware systems used ultrasound and electro-magnetic wave technologies, and of new
image processing methods or systems.
Professors:
SASADA, Masataka, M.D., D.Med.Sc. (Kyoto Univ.), 1. Hematology, internal medicine, infectious disease; 2. Analysis of
145
the mechanisms of host defense 3. Developing a new approach for the treatment of infectious diseases; 4. Analysis of
the pathophysiology of inflammation mediated by neutrophils
FUKUDA, Yoshihiro, M.D., D.Med.Sc. (Kyoto Univ.), 1.
Hepatology & gastroenterology; 2. Clinical immunology
FUJITA, Masatoshi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Cardiology, coronary circulation, integrated physiology; 2.
Clinical studies on coronary collateral circulation; 3. Congestive heart failure and coronary artery disease
OKA, Shogo, D. Pharm. Sci. (Kyoto Univ.), 1. Biochemistry,
glycobiology, molecular biology, neuroscience; 2. Functional
analysis of neural specific carbohydrate; 3. Glycobiological
approach for the development of the nervous system
SAITO, Kuniaki, D.Med.Sci. (Fujita Health Univ.), 1.
L-Tryptophan metabolisms; 2. HIV-related encephalopathy; 3.
Analytical biochemistry
SUGIMOTO, Naozo, D.Eng. (Kyoto Univ.), 1. Biomedical Imaging and Image Processing; 2. Computer Aided Diagnosis
Systems
SEIYAMA, Akitoshi, D.Sc. (Hokkaido Univ.), 1. Neuroscience;
2. Biophysics; 3. Biomedical Engineering
TAKAKUWA, Tetsuya, M.D., D.Med.Sc. (Osaka Univ.), 1.
Experimental pathology, Oncology; 2. Experimental study on
Lymphomagenesis arising in chronic inflammation
SHIINA, Tsuyoshi, D.Eng. (Univ. of Tokyo), 1. Biomedical
Engineering; 2. Development of Biomedical Imaging Technologies and Diagnosis Systems; 3. Medical Ultrasonics
IKEMOTO, Masaki, M.T., D.Med.Sc. (Kyoto Univ.), 1. Clinical chemistry, biochemistry, clinical biochemistry; 2. Clinical
and biochemical enzymology, immunopathology; 3. Study on
human liver-type arginase and its clinical significance; 4.
Study on a myeloid-related protein complex (MRP8/14) as an
acute inflammatory marker
OTSUKA, Kenichi, D. Sc. (Kyoto Univ), 1. Partial differential
equations; 2. Positivity of fundamental solutions for partial
differential operators, asymptotic distribution of eigenvalues
of elliptic partial differential operators
SASAYAMA, Satoshi, D.Med.Sc (Univ. of Tokyo), 1. Biomedical informatics, ergonomics; 2. Construction of pathogenic bacteria database system utilizing web technology; 3.
Application of continuous measurements of blood pressure
waveform during operation and exercise to the evaluation of
cardiovascular responses
IBUKI, Kentaro, D.V.M., D.Med.Sc. (Kyoto Univ.), 1. Virology and Immunology;
ITOH, Hiroshi, M.T., M.Med.Lab.Sc. (Tokyo Med Dent Univ.),
1. Host defense; 2. Hematology; 3. The effects of purines on
neutrophil functions
UENO, Tomohiro, Ph.D. (Kyoto Univ.),
1. Low temperature physics; 2. MRI; 3. NMR
YAMAMOTO, Yasuko, M.T., C.T. (IAC), D.Med.Lab.Sc.
(Osaka Univ.), 1. Molecular pathology
DEPARTMENT OF PHYSICAL THERAPY
Department of Physical Therapy is established with the aim
of producing able physical therapists with international expertise, foresight and intelligence. It is also engaged in the
study and development of innovative technology in the field
of physical therapy, which is one of the key modalities of rehabilitation medicine. Besides professional education and
146
training, priority is given to the development of sound medical ethics. Students are also provided with opportunities to
broaden their horizons by realizing the latest frontiers of
medicine at Kyoto University Hospital.
Professors:
TSUBOYAMA, Tadao, M.D., D.M.Sc. (Kyoto Univ.), 1. Orthopedics; 2. Bone metabolism; 3. Osteoporosis; 4. Musculoskeletal oncology;
KUROKI, Hiroshi, R.P.T., D.Med.Sc. (Kyoto Univ.), 1. Histology and bio-mechanics on articular cartilage; 2.Physical
therapy; 3. Rehabilitation for knee osteoarthritis;
ICHIHASHI, Noriaki, R.P.T., D.Med.Sc. (Fujita Health Univ.),
1. Orthopaedic physical therapy; 2. Clinical kinesiology; 3.
Physical fitness and sports medicine;
ISHIBASHI, Makoto, M.D.,Ph.D. (Kyoto Univ.), 1. Development of the central nervous system; 2. Head morphogenesis; 3.
Analysis of gene regulation; 4. Cell-to-cell communication
during development;
TAMAKI, Akira, R.P.T., Ph.D. (Hyogo College of Med.),
1. Pulmonary physical therapy; 2. Respiratory physiology;
4. Neural protection against ischemia; 5. Brain functional
improvement induced by rehabilitation;
TOICHI, Motomi, M.D., Ph.D. (Kyoto Univ.), 1. Clinical cognitive neuroscience of psychiatric disorder (autism, Asperger’s disorder, schizophrenia, bipolar disorder); 2. Child and
adolescent psychiatry; 3. Electrophysiology (Near-infrared
spectroscopy of the brain, electroencephalogram, analyses of
autonomic nervous system function); 4. Forensic psychiatry;
FUTAKI, Toshiko, M.S., Ph.D. (Showa Univ.), O.T.R.,1. Occupational therapy for physical disabilities; 2. Occupational
therapy for geriatrics; Rehabilitation for cognitive disorders;
KATO, Toshihiro, M.Ed., O.T.R., 1. Occupational therapy for
developmental disabilities; 2. Occupational therapy for educationally handicapped children;
KOSHIHARA, Kikue, M.S. (Occupational Therapy), O.T.R.,
1. Occupational therapy for mental disorders; 2. Activity adaptation for O.T.;
KASAHARA, Katsuyuki, M.D., D.Med.Sc. (Kyoto Univ.),
1. Orthopedics; 2. Oncology; 3. Immunology;
SAKAI, Hiroshi, M.S. (Occupational Therapy), O.T.R., 1. Occupational therapy for physiological disabilities; 2. Rehabilitation for higher brain dysfunctions;
Senior Lecturers:
OHATA, Koji, R.P.T., M.S. (Osaka Kyoiku Univ.), 1. Pediatric
physical therapy; 2. Neurological physical therapy
SHOJI, Mikiko, B.A.(Literature), O.T.R., 1. Occupational
therapy for children; 2. Supporting families of children with
disability;
MAEDA, Yuko, M.A. (Kyoto Univ.), 1. Medical Education
2.Public Health 3.Social Psychology
SHIRAI, Haruna, M.S. (Health Science), O.T.R.,
1. Well-being in dementia; 2.Occupational therapy for geriatrics;
IKEZOE, Tome, R.P.T., D.Sc. (Kobe Univ.), 1. Physical therapy for geriatrics;
TATEUCHI, Hiroshige, R.P.T., M.S. (Kobe Univ.), 1. Orthopaedic physical therapy;
Teaching Associate:
YAMADA, Minoru, R.P.T., M.S. (Kobe Univ.), 1. Orthopaedic
physical therapy; 2. Physical therapy for geriatrics
DEPARTMENT OF OCCUPATIONAL THERAPY
Education outline
Occupational therapy is believed to play very important
role for the rehabilitation. But in order to be recognized the
importance of this profession, the effect of the occupational
activities should be proved systematically, and scientifically.
Our program aims at the cultivation of the occupational therapist as a profession who will be able to problem solve and
further develop the profession.
Professors:
YAMANE, Hiroshi, Ph.D. (Kansai Med. Univ.), O.T.R., 1.
Occupational therapy for mental disorders; 2. Group dynamics and communication;
MITANI, Akira, Ph.D. (Kyoto Univ.), 1. Physiology; 2. Neuroscience; 3. Methodology of research; health neuroscience;
MATSUBAYASHI, Jun, M.S. (Science), 1. Basic research for
neurological rehabilitation of physical disabilities; 2. Functional brain imaging (magnetoencephalography and electroencephalography);
Teaching Associate:
ARAI, Noriko, O.T.R., 1. Occupational therapy for developmental disabilities;
CONTRIBUTED CHAIRS
DEPARTMENT
ONCOLOGY
OF
TRANSLATIONAL CLINICAL
Dept. of Translational Clinical Oncology has launched in
October, 2003 to facilitate translation of the scientific progress made during the past decade in the field of clinical research onto daily practice of clinical oncology.
Our research aims are development of better chemotherapeutic regimens in order to provide better quality of care for
cancer patients. To achieve this goal, we have constructed an
infrastructure for clinical trials in medical oncology. Examples are the clinical trial data managing system (Cyber Oncology ) and other clinical trial supporting tools. We are ac-
Medicine
tively conducting and supervising many high quality clinical
trials conducted at the Outpatient Oncology Unit of Kyoto
University Hospital.
Medical oncology lecture courses for physicians, pharmacists and nurses are in preparation. Graduate and undergraduate courses of medical oncology will start soon.
We are responsible for the patients care in the Outpatient
Oncology Unit of Kyoto University Hospital, where more
than 30 patients, on daily average, receive infusional chemotherapy as outpatient. The Unit is managed by full-time
staffs including medical oncologists, oncology pharmacists
and oncology nurses. Various clinical trials are ongoing,
along with the standard regimens for each cancer at the Unit.
Deputy Director and Program-Specific Associate Professor
(Endowed Chair):
YANAGIHARA, Kazuhiro, M.D., D.Med.Sc. (Kyoto Univ.),
1.Medical Oncology; 2.Thoracic Surgery
Program-Specific Assistant Professors (Endowed Chair):
MATSUMOTO, Shigemi, M.D.,
1. Medical Oncology; 2.Gastroenterology
KITANO, Toshiyuki, M.D.,
1. Medical Oncology; 2.Hematology
Program-Specific Senior Lecturer (Endowed Chair);
NISHIMURA, Takafumi, M.D., Med.Sc. (Kyoto Univ.),
1. Medical Oncology; 2. Tumor Biology
147
and function of lymphocytes, focusing on two important
questions: 1) Class switch recombination (CSR) and AID:
B lymphocytes switch antibody isotypes from IgM to others
adding diverse effecter functions to Ig with a given antigen
specificity. We revealed this phenomenon is mediated by a
region-specific recombination accompanied by deletion of Ig
constant region genes from chromosomes, which is now
called CSR. More recently we identified an RNA-editing
enzyme AID, which we showed critical for not only CSR but
also SHM, a mechanism for Ig affinity maturation. How
does single AID molecule control the two totally different
processes, CSR and SHM? Accumulating evidence suggests
that AID binds to two separate co-factors to edit
yet-to-be-identified target mRNAs required for CSR or SHM.
We are now poised to discover such target mRNAs and
co-factors to unveil the molecular mechanism of CSR. 2)
Autoimmunity and PD-1: We showed mice deficient in
PD-1, a negative regulator for immune responses, develop
autoimmune diseases such as dilated cardiomyopathy and
systemic lupus erythematosus. As these symptoms vary depending on genetic backgrounds of mice, we are trying to
identify genes which cooperate with PD-1 and control development of autoimmune diseases.
Professor:
HONJO, Tasuku, M.D., D.Med.Sc. (Kyoto Univ.), Regulatory
mechanism of lymphocyte differentiation;
NAGAOKA, Hitoshi, M.D., D.Med.Sc. (Kyoto Univ), B lymphocyte biology;
DEPARTMENT OF IMMUNOLOGY AND GENOMIC
MEDICINE
SHINKURA, Reiko, M.D., D.Med.Sc. (Kyoto Univ.), Molecular mechanism of class switch recombination;
Immune system can react against virtually unlimited variety of foreign antigens in highly regulated manner. This
phenomenon has been one of the biggest mysteries in biology.
Recent advances in immunology and molecular biology are
shedding light on molecular mechanisms that are operating in
the system. Because they are related with various diseases,
such as autoimmune, tumorigenesis, etc., the research on this
field is expected to benefit clinical science as well as basic biology.
The Department of Immunology and Genomic Medicine
was founded in April 2005 as a contributed chair sponsored
by Ono Pharmaceutical Co., Ltd. The department aims to
perform basic and translational research in Immunology and
Genomic Medicine, thereby making significant contributions
to bioscience and medicine. Dr. Tasuku Honjo was appointed as the professor. He is a world wide leader in the
immunogenetics who received the Asahi Award, the Kihara
Award of Japanese Genetic Society, the Takeda Medical
Award, the Behring-Kitasato Prize, the Uehara Award and the
Imperial Prize from Japan Academy. Also, he is a foreign associate of National Academy of Sciences, U.S., and honored
as a person of cultural merit by Japanese government
BEGUM, Nasim A., Ph.D. (Visvabharati Univ., India), Molecular mechanism of class switch recombination;
Teaching activities cover the following: 1. Regulation of
immune response; 2. Mechanism for antibody diversification;
3. Function of cytokines; 4. Genome stability.
We study molecular mechanisms controlling development
CHIKUMA, Shunsuke, D.V.M., Ph.D. (Medicine; Hokkaido
Univ.), Genetic mechanisms of autoimmune diseases;
DEPARTMENT OF ORGAN PRESERVATION TECHNOLOGY
TEL : +81-75-751-4975
FAX : +81-75-751-4974
e-mail : orpteckuhp.kyoto-u.ac.jp
Research and Education
Transplantation of various organs including the lungs, heart,
liver, kidney, islets, and small intestine has been established as
a solo therapeutic option for end-stage organ dysfunction.
Additionally, various therapies including bone marrow transplantation for leukemia, immunotherapy for cancer, and replantation of amputated digits are emerging.
However, the quality and quantity of organs, tissues and
cells transplanted after preservation is not yet satisfactory.
Therefore, elucidating the mechanisms of functional deterioration after preservation and improving the quality of organs,
tissues, and cells would directly benefit patients for those advanced therapies. Reliable methods of preservation would
enable the use of marginal donors and alleviate the shortage
of donor organs. Good function of preserved organs, tissues,
148
and cells would lessen complications after therapies and contribute to medical economy. Further, knowledge on organ,
tissue and cell preservation would also provide better results
in regenerative medicine.
Our department would like to support collaborations between many researches, and perform basic as well as
pre-clinical studies.
BANDO, Toru, M.D., Ph.D. (Kyoto Univ.), Thoracic surgery
FUJINAGA, Takuji, M.D., Ph.D. (Kyoto Univ.), Thoracic surgery
CHEN, Fengshi, M.D., Ph.D. (Kyoto Univ.), Thoracic surgery
1.Respiratory Insufficiency, 2.Sleep disordered breathing, 3.
Respiratory medicine
Senior Lecturer:
OGA, Toru, M.D., D.Med.Sc. (Kyoto Univ.), Respiratory
medicine
SUGIYAMA, Hanako, M.D. 1.Clinical Neurophysiology,
2.Brain Pathophysiology
CAREER-PATH PROMOTION UNIT FOR YOUNG
LIFE SCIENTISTS
See “CAREER-PATH PROMOTION UNIT FOR YOUNG
LIFE SCIENTSTS” in CENTERS pages for details.
DEPARTMENT OF RESPIRATORY CARE AND SLEEP
CONTROL MEDICINE
5. RESEARCH FACILITIES
The department of respiratory care and sleep control medicine was newly established in Kyoto University, Faculty of
Medicine, in April 2008. The purpose of this department is to
investigate the best respiratory care and the pathophysiology
and pathogenesis of sleep disturbance and sleep-disordered
breathing that have significant effects on systemic diseases.
INSTITUTE OF LABORATORY ANIMALS
The major fields in research are follows:
1. Respiratory care for acute and chronic respiratory failure
2. Pathophysiology of sleep disturbance and sleep-disordered
breathing
3. Diagnosis and treatment for sleep-disordered breathing and
sleep disturbance
4. Noninvasive and invasive ventilatory support
5. Development of new strategy for respiratory care and sleep
medicine
This department is responsible for teaching respiratory failure and sleep medicine to undergraduate students and for instructing basic and clinical studies in respiratory care and
sleep medicine, especially sleep disordered breathing to
graduate students. For the respiratory care and sleep disordered breathing, we are also responsible for clinical training
of clinical fellows and residents in the department of University Hospital.
In cooperation with the other departments, we provide the
proper respiratory care for the in-patients during awake and
sleeping time including perioperative stage in the University
Hospital. The department undertakes diagnosis and treatment
of sleep-disordered breathing and sleep disturbance. We are
also responsible for out-patient wards in the University Hospital, and taking care of patients with respiratory failure, sleep
disturbance and/or sleep-disordered breathing who use noninvasive ventilator with or without the home oxygen therapy.
Professor:
CHIN, Kazuo, M.D., M.Med.Sc. (Kyoto Univ.), 1.Respiratory
Insufficiency, 2.Sleep disordered breathing, 3. Respiratory
medicine
TSUBOI, Tomomasa, M.D., M.Med.Sc. (Kyoto Univ.),
Director: SERIKAWA, Tadao, D.V.M., D. Agr.
Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501
Tel. +81-75-753-4489
Fax. +81-75-753-4409
The Institute of Laboratory Animals was established as one
of the research institutes in the Faculty of Medicine, Kyoto
University in 1972, and a new building was constructed in
2003. The building includes 6 floors covering an area of
9,400 m2, and has extensive facilities for animals, laboratory
experiments and operations. There are a number of caged
animal rooms for mice and rats. In addition, the animal-keeping facilities have a racked cage system equipped
with automatic waste-disposal, watering and feeding devices,
maintaining healthy and sanitary conditions, as well as saving
labor. The Institute is a core center of National BioResource
Project for the Rat in Japan.
The Institute is dedicated to and actively engaged in:
1. performing animal experiments, primarily with mice, rats,
hamsters, guinea pigs, rabbits, cats, dogs, and non-human
primates
2. keeping and supplying various inbred and mutant strains of
rats
3. carrying out education and research in laboratory animal
sciences
4. offering advice on animal experiments and information on
laboratory animals to medical doctors and scientists.
Professor:
SERIKAWA, Tadao, D.V. M., D. Agr. (Osaka Prefecture Univ.),
Laboratory animal science
KURAMOTO, Takashi, D. Med.Sc. (Kyoto Univ.), Laboratory
animal science
CONGENITAL ANOMALY RESEARCH CENTER
Director: KANEKO, Takeshi, M.D., Ph.D.
Tel. +81-75-753-4345 Fax. +81-75-753-4621
The Congenital Anomaly Research Center was established
Medicine
on April 1, 1975 in the Faculty of Medicine. The founder and
the first Director of the Center, the late Professor Hideo Nishimura, initiated systematic collection of human embryonic
and fetal specimens, especially those at the period of major
organogenesis. The collection of human conceptuses was initiated in 1961 and various aspects of normal and abnormal
human prenatal development have been investigated. This effort has been energetically continued in collaboration with a
number of obstetricians, pediatricians, and other physicians.
Most of the human prenatal specimens have been procured
after termination of pregnancy for social reasons and therefore
the embryo population can be regarded as a representative of
the total intrauterine population in Japan. The total number of
specimens collected so far exceeds 44,000. Of those specimens, approximately 1,000 cases have been histologically
prepared in serial sections. The human embryo collection and
associated clinical data are made available for scientific research and medical education.
The main purposes of the Center are: 1. to establish normal standards of human prenatal development; 2. to investigate the initiating processes and pathogenetic mechanisms of
various congenital malformations; 3. to make genetic epidemiological studies of human congenital malformations and
identify genetic and environmental factors responsible for
human birth defects; 4. to make the human embryo data
available for birth defects monitoring; 5. to make the Center's
collection of human conceptuses available for scientific research; 6. to furnish embryonic and fetal specimens for education in medical embryology and teratology for graduate and
undergraduate students; and 7. to give advice to clinicians and
scientists in related fields concerning the problems of human
birth defects.
In addition to the studies with human embryos and fetuses,
experimental studies using animal models are also conducted
to elucidate the mechanisms of abnormal development.
YAMADA, Shigehito, M.D., D.Med.Sc. (Kyoto Univ.),
1. Normal and abnormal human development; 2. Imaging of
human embryos; 3. Clinical dysmorphology; 4. 3D visualization of human embryos;
CENTER FOR ANATOMICAL STUDIES
(FORMERLY STUDY CENTER FOR HUMAN REMAINS)
Director: MANABE, Toshiaki, M.D., FCAP.
Tel. +81-75-753-4496
This center was founded in 1981 as a model institution to
conduct integrated research and education for gross anatomy
and pathologic and forensic medicine. The building has a
basement and four floors covering an area of 5,065m2. The
eastern wing consists of two autopsy rooms for forensic
medicine and pathology, a research laboratory and exhibition
rooms for medical history, and valuable autopsy specimens.
The western wing consists of a room for gross anatomy, an
auditorium and two rooms for histology practice and audio-visual education. The computer-assisted educational room
of the center for information and multimedia studies is also
located on the 2th Floor. There is a large collection of microscopic/macroscopic specimens and pathology case records
since 1900.
149
Professor:
MANABE, Toshiaki, M.D., FCAP., 1. Surgical pathology; 2.
Pulmonary pathology; 3. Dermatopathology
KOTANI, Hirokazu, M.D., D.Med.Sc. (Mie Univ.), Anatomic
pathology;
CENTER FOR GENOMIC MEDICINE
CENTER FOR GENOMIC MEDICINE
Director: MATSUDA, Fumihiko, D.Med.Sc. (Kyoto Univ.)
Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501
Tel. +81-75-753-4661
Fax. +81-75-753-9314
The center was established in April 2004 by converting
Center for Molecular Biology and Genetics that directly was
belonging to the University to join to the Graduated School of
Medicine. A part of Department of Genome Epidemiology
in the Graduate curriculum of Public Health was also converted to join to this center. Major research aim of the center
is to identify the genes responsible for the onset and progression of human multigenetic disorders and to analyze their
function. The center consists of two units, Unit of Human
Disease Genomics and Unit of Genome Informatics. The
third unit, Unit of Statistical Genetics will soon be created.
In January 2007, a research unit for trans-ethnic genetic studies of multigenetic disorders (Unit 852) was created with financial support of Institute National de la Santé et de la Rechérche Médicale (INSERM) in France to further reinforce
international collaboration in the field of genomics.
The Center mainly occupies approximately 500
in the
departments in the graduate curriculum in the Medical
School.
Unit of Human Disease Genomics
Study of human diseases based on genetic information is
one of the most important subjects in the Post Genome Project.
In particular, to overcome human multigenetic disorders, it is
essential to perform trans-ethnic genetic analyses of human
genome variations. In our unit, we perform genome wide
association studies (GWAS) of a variety of diseases with SNP
arrays using DNA samples (at the order of 1,000) of disease
patients and control subjects from different ethnic origins.
The projects include rheumatoid arthritis, chronic HCV disease, radiation-induced childhood thyroid cancer, lung cancer
and adult T-cell leukemia. We try to establish a new generation genome variation-based genomic strategy which will be
directly linked to clinical research and therapeutics.
Professor:
MATSUDA, Fumihiko, D.Med.Sc. (Kyoto Univ.), 1. Molecular
biology; 2. Human genetics;
KADOTANI, Hiroshi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Sleep
Research; 2. Epidemiology;
Associate Professor of Industry-Government-Academia
Collaboration:
MURAKAMI, Yoshiki, M.D., Ph.D. (Kyoto Prefectural Uni-
150
versity of Medicine), 1.Virology; 2.Hepatology;
Research Associate:
TAKAHASHI, Meiko, Ph.D. (University of London), Cancer
genetics;
Research Scientist:
TAKIGAWA-IMAMURA, Hisako, D. Sc. (The Graduate University of Advanced Studies), 1. Mathematical biology; 2. Molecular biology;
Unit of Genome Informatics
Major goal of research in this unit is
(1) to establish bioinformatics system which can handle
large-scale disease genomics studies such as GWAS,
prospective cohort studies and whole genome sequencing
approaches. This includes the construction of a comprehensive SNP database of different multigenetic diseases
which integrates genetic and clinical information.
(2) to understand molecular mechanisms underlying gene
regulation and genome evolution by comparative genomic
approaches. The projects involve (i) identification of regulatory elements, such as transcription factor binding sites
and splicing regulators, and (ii) molecular evolutionary
analyses of gene duplications and genome rearrangements.
Professor:
SEKINE, Akihiro, D.Med.Sc. (Kyoto Univ.), Human Genetics;
SUYAMA, Mikita, D.Agr.Sc. (Kyoto Univ.), Comparative Genomics;
Research Scientist:
MIZUSAWA, Seiho, M.Sc. (Tsukuba Univ.), Human Genetics;
CENTER FOR MEDICAL EDUCATION
Director: HIRAIDE, Atsushi, M.D., D.Med.Sc. (Osaka Univ.)
Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501
Tel: +81-75-753-9338
Fax: +81-75-753-9339
http://plaza.umin.ac.jp/~cme/index.html
In these days, topics concerning about medical education
became one of important issues for our community. Traditional style of medical education has been carried out mainly
by the effort of individual department of medical school. It
has been, however, impossible nowadays that we provide a
qualified medical education without coordination of the effort
of individual section. Center for Medical Education has
been newly established in 2004 to act a central role for promotion of a qualified medical education.
Outline of Teaching and Research Activities:
Center for Medical Education is not one of departments in
medical school. It has been established in order to promote
medical education as a faculty. Therefore it is not for a specific research or an education carried out in individual department.
Now the center is revising the framework of curriculum of
basic medicine for biomedical science and public health.
We are also changing our clinical training course to a clinical clerkship-based new pathway instead of a traditional
bed-side learning curriculum. Our activity is also concerned
with the post-graduate resident course.
Not only in making a better system for medical education,
the center is also engaged in a development of programs for
learning, such as a new program for Medical English in basic
field, and a practical resuscitation program for sudden cardiac
arrest patients in clinical field.
Professor:
HIRAIDE, Atsushi, M.D., D.Med.Sc. (Osaka Univ.), 1.Medical
education; 2.Emergency medicine; 3.Resuscitation;
Senior Lecturer:
MORIMOTO, Takeshi, M.D., D.Med.Sc. (Kyoto Univ.),
M.P.H.(Harvard Univ.), 1. Medical Education; 2. Clinical
Epidemiology; 3. Patient Safety; 4. General Internal Medicine;
SAKUMA, Mio, M.D., D.Med.Sc. (Jikei Univ. school of Medicine), M.P.H.(Harvard Univ.), 1. Medical Education;
2. Clinical Epidemiology; 3. Pediatrics;
Teaching Associate:
SEKI, Susumu, 1. Medical Education; 2. Human Interface;
HUMAN BRAIN RESEARCH CENTER
In April 2000, the Human Brain Research Center was
newly founded in affiliation with the Graduate School of
Medicine in order to further advance the studies of human
brain functions using various modern technologies such as
electrophysiology, magnetoencephalography, positron emission tomography, single photon emission computed tomography, functional magnetic resonance imaging, and transcranial
magnetic stimulation. The Center is formed of three Departments; Brain Pathophysiology, Functional Brain Imaging, and
Psychophysiology. Professor Hidenao Fukuyama, M.D. is
serving as the Director of the Research Center. The Department of Brain Pathophysiology which belonged to the Graduate School of Medicine moved to this Center, becoming its
principal constituent. The Department of Functional Brain
Imaging is mainly developing the methods of magnetic resonance imaging of the human brain and detecting functional
brain activation by metabolic or blood flow change. The Department of Psychophysiology invites a foreign scientist each
year. In order to explore more widened view of human brain
function, this center is actively collaborating with faculties of
letters, pharmaceutical sciences, and engineering.
Department of Brain Pathophysiology
This Department was founded in April 1990 as one of the
three core sub-departments forming a new post-graduate
course in the Faculty of Medicine called the Division of Integrative Brain Medical Science. Since 1995 it belonged to the
Section of Clinical Neuroscience as a result of a change from
the Faculty of Medicine to the Post-Graduate Course of
Medical Science. The primary aim of this Department is to
clarify the mechanisms underlying brain activities such as
Medicine
cognitive, motor and memory functions in normal humans
and their disturbances in patients with various diseases affecting the higher brain functions. In order to accomplish this
aim, this department mainly utilizes electrophysiological
measures which preferentially resolve temporal profiles of
brain activities. As described above, the Department has belonged to the newly founded Human Brain Research Center
since April 2000.
MIMA, Tatsuya, M.D., D.Med.Sc. (Kyoto Univ.), Electrophysiology of the central nervous system and motor control;
SAWAMOTO, Nobukatsu, M.D., D.Med.Sc. (Kyoto Univ.),
Basal ganglia function and its dysfunction;
151
and seminars in cooperation with the Management of Technology in Medical Science Course and provided much support
to faculties and laboratories in promoting their research and
developing the relationship with industry.
LIAISON AND COORDINATION
KUMBL provide supports for Industry-Academia relations
(1) by excavating and collating the seed technology (both disclosed and undisclosed), which may potentially become the
subject of collaboration with industry, (2) by disclosing the
latest information at Kyoto University on research activities,
drug-development/ clinical investigation, life and medical
ethics, and on other information as may be requested by the
public, and (3) by providing advice and support to each industry-academia collaborations (e.g. development of a new
drug or medical instrument).
Department of Functional Brain Imaging
PATENT PROSECUTION
The Department of Functional Brain Imaging was newly
developed at the beginning of this center. Professor Fukuyama,
M.D. was affiliated as the chairman of this department since
January 1st, 2001. This department is dedicated to the examination and research works on the neurological disorders and
neuronal functions using brain imaging techniques, such as
positron emission tomography, single photon emission CT
and MRI. These measures are specifically adequate to unravel
brain functions from the viewpoint of spatial extent and its
connectivity. In collaboration with the Department of Brain
Pathophysiology, we try to disclose functional aspect of neurological disorders as well as the neuronal mechanisms in the
healthy human subjects.
In cooperation with the Office of Society-Academia Collaboration for Innovation (SACI), administration office, and
Innovative Collaboration Center (ICC), KUMBL provides
administrative supports for filing of patent by coordinating
between researchers and administration.
Professor:
FUKUYAMA, Hidenao, M.D., D.Med.Sc. (Kyoto Univ.), PET
studies on neurological disorders and brain functions;
MATERIAL TRANSFER
YAMAUCHI, Hiroshi, M.D., D.Med.Sc. (Kyoto Univ.)
PET examinations on Neurological disorders;
LICENSING
In cooperation with Shirankai Business Liaison Office,
KUMBL discloses newly filed patents selected by the Invention Evaluation Committee (Medical and Bioscience Division) of Kyoto University to Shiran Society (a membership
society consisting mainly of pharmaceutical companies).
KUMBL supports the execution of MTA (Material Transfer
Agreement) for provision and receipt of research materials
(e.g. cells, DNA etc.) to and from other universities or companies in and outside Japan.
EDUCATION
URAYAMA, Shin-ichi, M.Sc. (Kyoto Univ.), Development of
analytical procedures for neuroimaging studies;
KUMBL (Kyoto University Medical Science and Business
Liaison Organization)
-THE BRIDGE BETWEEN LABORATORY AND
INDUSTRY IN THE FIELD OF MEDICINE-
Through hosting seminars and symposiums, KUMBL provides latest information from in and outside Japan relating to
research and intellectual property. KUMBL also supports
Management of Technology and Intellectual Property, which
fosters human resources who are capable of working for industry-academia relations.
START-UP SUPPORT (INCUBATION PLAZA)
As a run-up to the incorporation of national university, in
April 2002, Graduate School of Medicine set up a Business
Liaison Office (which formed a part of KUMBL) as one of its
measure to promote the exploitation its research outcome; one
of the three important missions to be fulfilled along with its
mission of education and research.
Since the incorporation in April 2004, it continued to grow
to provide wider support for academia-industry relations not
only for Graduate School of Medicine but also for other
schools and institutes in the field of medical science.
In April 2005, it launched its sub-wing, Incubation Plaza to
support the establishment of spin-out companies. Till date, it
has held a number of national and international symposiums
To promote the return of research outcome to society, Mitsubishi UFJ Capital Co., Ltd. and Sumitomo Corporation together take part to form Incubation Program Committee set up
within KUMBL. From April 2005, operating under the
name “Incubation Plaza”, it selects projects to invest and form
university spin-out companies. The spin-out will collaborate
with university to further develop the research base for business application.
Director-General:
MITSUYAMA, Masao, M.D., Ph.D. Professor (Kyoto Univ.),
Dean, Kyoto University Graduate School of Medicine
152
Deputy Director:
TERANISHI, Yutaka, D. Eng. (Kyoto Univ.), Professor, Management of Technology and Intellectual Property,, School of
Public Health, Graduate School of Medicine; Industrial Relations Manager, Business Liaison Office of Faculty of Medicine
Email:
URL: http://www.med.kyoto-u.ac.jp/J/KUMBL
*The name “medical science field” indicates Faculty of
Medicine, Graduate School of Medicine, Faculty of Pharmacy,
Graduate School of Pharmacy, Graduate School of Biostudies,
Institute for Virus Research, Institute for Frontier Medical
Science, Kyoto University Hospital, and related field such as
Primate Research Institute and Radium Biology-Center.

graduate school of medicine / faculty of medicine school of public

Transcription

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