2013 - Erasmus MC

Transcription

2013 - Erasmus MC

COEUR
Annual Report
2013
COEUR Course Cardiovascular Medicine December 2013
2
Contents
Preface
5
Mission
11
Organization
13
Grants and Awards
15
Education
23
PhD training
23
Research Seminars
23
Other educational activities
25
MD elective program
26
Research
35
Doctoral degrees
99
Citation Classics
108
PubMed Publications 2013
109
Colofon
168
3
4
Preface
We proudly present the annual report of the Cardiovascular Research School COEUR for
the year 2013. In terms of scientific output, 2013 has been a fruitful year. Our staff and
PhD candidates altogether produced 588 PubMed articles, whereas 24 PhD candidates
successfully defended their thesis and obtained a doctoral degree. Drs. Van der Linde
and Mokhles earned the doctorate ‘cum laude’, for which they are to be congratulated.
Details on the PhD theses can be found in the chapter on Doctoral Degrees.
The strong earning power of COEUR is reflected by the large amount of grant funds
that have been raised by COEUR investigators. As described in the chapter on Grants
and Awards, in 2013 a total of over 25 million euro was raised. In particular our scientists in heart valve disease, congenital heart defects, the heart-brain connection and
cardiovascular imaging have been successful.
The reporting year 2013 was memorable for our colleagues De Jaegere, who was appointed professor of Interventional Cardiology, and Takkenberg, who was appointed
professor of Clinical Decision Making.
Professor E. Sijbrands has been appointed Raine professor at the School of Medicine
and Pharmacology, Perth, Australia. Young investigator and presentation awards were
obtained by several of our PhD candidates.
This report presents a photo impression of the ‘COEUR day’, which was held on May 31.
We aimed to outline the strengths and capacities of the various project groups, in order
to foster collaboration and research within COEUR. By means of short lectures, a poster
walk, and debating sessions, senior staff and PhD candidates used the opportunity to
share insights and ideas. The COEUR day was well-attended and -appreciated and will
henceforth be organised as an annual event.
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C O E U R Annual Report 2013
COEUR currently lists 199 PhD candidates, who conduct their research in one of the 37
projects, which belong to the three main themes Vascular Medicine, Acute Coronary
Syndromes and Chronic Cardiac Disease. This structure was created upon recommendation by the 2009 accreditation committee of the Royal Netherlands Society of Arts and
Sciences. In 2014, COEUR will again be inspected and reviewed. We are curious to learn
how our scientific and educational undertakings and achievements will be appreciated
by external reviewers.
In the meantime, we hope that you will enjoy the presentation of our activities in this
annual report. We wish all COEUR staff and PhD candidates an exciting and successful
scientific 2014.
Eric Boersma, Scientific Director
Adrie J.M. Verhoeven, Secretary
Felix Zijlstra, Chairman
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Professor Eric Boersma, Scientific Director
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Dr. Adrie J.M. Verhoeven, Secretary
8
9
Dr. Shirley Uitte de Willige
Dr. Dick Rijken in “Cardiovascular Medicine” Course
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Mission
The mission of COEUR is two-fold:
■ To promote basic, translational and clinical
cardiovascular research, aimed at improving
the understanding of the pathophysiology
as well as the prognosis and quality of life of
patients with cardiovascular disease
■ To train future national and international
leaders in the cardiovascular field through a
systematic scientific education and training
program
To achieve this mission, COEUR conducts
innovative research and provides high quality
training in the cardiovascular research field.
The research programs include a wide spectrum
of disciplines, such as cardiovascular biology
and pharmacology, biomedical engineering and
informatics, clinical science, clinical epidemiology
and health care research. Training involves an
individual training program and includes monthly
research seminars and an all-encompassing
cardiovascular science core curriculum.
COEUR recognizes the need for an integrative,
multidisciplinary, translational approach
and encourages national and international
collaboration.
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Cardiovascular Research School Erasmus University Rotterdam (COEUR)
Participating institutes
Board representatives
Anesthesiology and Vascular Surgery
Professor Robert Jan Stolker
Cardiology
Professor Felix Zijlstra, chairman
Cardiothoracic Surgery
Professor Ad JJC Bogers
Hematology
Professor Frank WG Leebeek
Intensive Care Medicine
Professor AB Johan Groeneveld
Internal Medicine, Pharmacology,
Vascular and Metabolic Diseases
and Division of Nephrology
Professor AH Jan Danser
Dr Anton H van den Meiracker
Professor Bob Zietse
Neurology (Vascular Neurology)
Professor Diederik WJ Dippel
Pediatric Cardiology
Professor Wim A Helbing
Radiology
(including Biomedical Imaging)
Professor Aad van der Lugt
Professor Wiro J Niessen
Surgery (Vascular Surgery)
Professor Hence JM Verhagen
Professor Eric Boersma, scientific director
Dr Adrie JM Verhoeven, secretary
Accredited (2003) by the Royal Netherlands Academy of Arts and
Sciences. Re-accreditated in 2009
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Organization
10 COEUR participants
Anesthesiology
Cardiology
Graduate School
Erasmus MC
Cardiothoracic Surgery
Hematology
Intensive Care Medicine
COEUR
Scientific Advisory Board
COEUR
Board
Internal Medicine
Pharmacology, Vascular and
Metabolic Diseases
and Division of Nephrology
Neurology
Pediatric Cardiology
Executive
Committee
Scientific Director
Radiology
Biomedical Imaging Group
Vascular Surgery
Scientific Secretariat
Theme I
Vascular Medicine
Theme II
Acute CV Syndromes
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Theme III
Chronic Cardiac Disease
Denise van der Linde is EPAR PhD Student of the Year
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Grants and Awards
A selection of grants and awards obtained by COEUR investigators in 2013 is given below.
Cardiology
PhD candidate Denise van der Linde was awarded
with the title of EPAR PhD Student of the Year
2012 for being the most outstanding and unique
PhD student at Erasmus University Rotterdam. In
this competition, the PhD candidates’ association
of Erasmus University Rotterdam EPAR searches
for PhD students who – besides their excellent
research activities – have time and energy to be-
Petra Opiç with the Young Investigator Award
come involved in extracurricular activities like
entrepreneurship, voluntary work and political
involvement. The nominated students all excel in
society involvement, connections within their research field and academic achievements. The prize
was presented to her during the Talent Day on
February 19th, 2013 and included an award-statue
and a financial prize (€ 1.000).
During the meeting of the Association for
European Paediatric and Congenital Cardiology
(AEPC) “Psycho-Social from Fetus to Adult” in Cologne, Germany, PhD candidate Petra Opiç won
the Young Investigator Award with her presenta- 15
tion “Sexual functioning is worse than expected
Dr Peter de Jaegere has been appointed professor
of “Intervention Cardiology, particularly cathetherrelated treatments of valve defects”. On January
11th he delivered his inaugural lecture titled
“Standing still promotes progress”.
in adults with congenital heart disease”. She performed this study as part of the 30-year follow-up
of patients with congenital heart diseases. This
was the third follow-up in this unique longitudinal cohort, in which patients were not only examined medically, but also underwent extensive
psychosocial examination. The first and second
follow-ups took place at 1990 respectively 2001.
Project leaders were Professor Jolien Roos-Hesselink and Dr Lisbeth Utens (Department of Child
and Adolescent Psychiatry/Psychology, Erasmus
Medical Center).
In 2013, PhD candidate Matthijs van
Kranenburg received financial support for
his project The sudden heart attack from the
Stichting DIRA(mr. Moerman).
On November 28th Professor Patrick W. Serruys
was awarded an honorary doctorate by the
Complutense University of Madrid.
PhD candidate Denise van der Linde obtained her
PhD degree ‘cum laude’. Her thesis defense was
at April 19th, and the title was “Congenital Aortic
Stenosis and Aneurysms”.
Professor Dirk Duncker received an Erasmus
MC Pilot Grant worth € 50.000,- for research on
wound healing in the infarct area after an acute
myocardial infarction, in collaboration with
Dr. Han van Neck (Plastic Surgery). In addition,
he has been appointed as Associate Editor of
Cardiovascular Research (the basic science journal
of the European Society of Cardiology) as of
January 1st 2013.
The BAV consortium (LUMC, UMC St. Radboud
and Erasmus MC), in which the department
of Congenital Heart Disease is an important
participant, received a grant (€ 1.000.000) from
the Dutch Heart Foundation for study called
“Unravelling etiology and risk factors in patients
with bicuspid aortic valves”.
Dr Daphne Merkus received a CVON grant for
her part in the project Phaedra: Pulmonary
Hypertension and associated Right Heart Failure:
breaking the vicious circle. This project is run
together with Anton Vonk Noordegraaf, Harm-Jan
Bogaard and Geerten Nieuw-Amerongen from the
VUMc, Peter ten Dijke and Marie-Jose Goumans
from the LUMC, and Rolf Berger from the UMCG.
In 2013, the unit Translational Electrophysiology
was founded as a new research unit at the
department of Cardiology. Dr Natasja de Groot
received a research grant (€180.000) from the
Thorax Foundation.
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The 1Valve consortium (1Valve: one valve for
live) of which Professor Arie Pieter Kappetein is
one of the two leaders, and professor Hanneke
Takkenberg is principal investigator, received
a CVON grant worth € 9.000.000, for their study
aimed at the development of in situ engineering
of heart valves.
Daphne’s part in this project is the development
and study of two pig models for pulmonary
hypertension. The focus lies at the adaptations
of lung endothelial cells and the right ventricle
to the altered hemodynamics, and the role of
TGFbeta and BMP signaling in these adaptations.
She receives about €715,000 for two PhD students,
one technician plus bench fee.
PhD candidate Mostafa Mokhles obtained his
PhD degree ‘cum laude’ at December 16th, for his
thesis titled .“Innovative Modeling of Outcome in
Cardiac Surgery”. PhD candidate Aart Mookhoek
received the prize for best presentation at the
COEUR day 2013 for his talk “Material Properties
of Failing Pulmonary Autografts”.
Dr Heleen van Beusekom received an NWO
investment grant together with Dr Gijs van Soest
and dr Theo Luider (Neuro-oncology) to acquire
an MS imaging suite to study pharmacodynamics
of drug delivery and biodegradable scaffold
behavior (€900.000), and a grant of € 120.000 from
the Dutch Trombosis Foundation (together with
Dr Moniek de Maat (Hematology)) to study the 3D
functional architecture of coronary thrombi in the
CorTAsk biobank.
Cardio-thoracic Surgery
Dr Hanneke Takkenberg has been appointed as
extraordinary professor occupying an endowed
chair on behalf of the Erasmus Trust foundation,
in Clinical Decision Making. On September 6th she
delivered her inaugural lecture titled “Dance with
chance”.
Dr. Mostafa Mokhles
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On June 10th, 2013, PhD candidate Ruben
Osnabrugge, received a Fulbright scholarship
out of the hands of Minister Jet Bussemaker
and American Chargé d’Affaires, Edwin Nolan.
The Fulbright program is an international
educational exchange program sponsored by
the US government and is designed to “increase
mutual understanding between the people
of the United States and the people of other
countries.” The Netherlands has participated
in this program since 1949. The main criteria
for granting the scholarship are: outstanding
academic performance; being regarded as
promising in their field; and being capable of
representing the Netherlands in the United States.
Ruben was one of the 10 PhD students who were
awarded with this scholarship this year. This
scholarship enables him to conduct part of his
research at the Mid-America Heart Institute in
Kansas City, Missouri. His research focuses on less
invasive treatments for coronary artery disease
and aortic valve stenosis. In addition to the clinical
outcomes, his research will concentrate on the
quality of life and the costs associated
with these treatments. The Mid-America
Heart Institute is an authority in this
field of research.
Ruben Osnabrugge with
Minister Jet Bussemaker
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Hemostasis and Thrombosis
Postdoctoral researcher Dr Shirley Uitte de
Willige received the 2013 Joint Fellowship
100 K€) from the International Society of
Thrombosis and Hemostasis (ISTH) and the
European Hematology Association (EHA) for her
research on alpha-2-antiplasmin. She also won a
Pier M. Mannucci Award for best articles by young
authors published in the Journal of Thrombosis
and Haemostasis in 2012.
Professor Frank Leebeek, Dr Moniek de Maat,
Dr Marieke Kruip, Dr Dick Rijken and Dr Shirley
Uitte de Willige were members of the local
organizing committee of the XXIVth International
Congress of the International Society of
Thrombosis and Haemostasis, held in Amsterdam
29 June - 4 July 2013.
PhD candidate Yvonne Sanders received a Young
Investigator Award from the ISTH for her abstract
“Genetic variations determine von Willebrand
factor levels in patients with von Willebrand
disease – the WiN study”.
Dr Moniek de Maat received a grant from
Stichting Coolsingel for the project Fibrin
treatment: turning point in chronic wound healing
(40 K€) and a grant from the NOVO Nordisk/ECAT
Foundation worth 50 K€ for the project External
Quality Control Hemostasis: interaction between
laboratory and clinicians in the Netherlands.
Together with dr. J van Neck (Plastic Surgery) she
received an additional 100 K€ from the Fonds
NUTS-OHRA, for the project Fibrin treatment:
turning point in chronic wound healing. Together
with Dr Heleen van Beusekom, she received
a grant of 120 K€ from the Dutch Trombosis
Foundation for the study titled Functional
three-dimensional architecture of the coronary
thrombus in relation to phenotype: in vivo and in
vitro thrombus fate.
PhD candidate Carina Stoof received an NVTH
Award of Excellence (€ 2000,-) for her work on
“High rate of postpartum hemorrhage in women
with Von Willebrand Disease and carriers of
hemophilia, despite specialized care”. Additionally,
she received a Young Investigator Award from the
ISTH for this work.
Dr Janine van Loon was awarded a Pier M
Mannucci Award for best original articles
published by young investigators in the Journal of
Thrombosis and Haemostasis in 2012.
Dr Marieke Kruip received a grant from Fonds Nuts
Ohra for a study on unexplained bleeding tendency
(150 K€) and an unrestricted research grant from
Thrombosis Service Star-MDC for studies on
treatment with oral anticoagulants (200 k€).
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Internal Medicine: Pharmacology, Vascular
and Metabolic Diseases
Paediatrics
The consortium COBRA - Congenital heart
defects: Bridging the gap between Regeneration,
Adaptation, late Attrition and Ageing -, for which
professor Wim Helbing and VM Christoffels
(AMC Amsterdam) are the leading PI’s, received
a consortium grant of € 1.500.000 from the
Netherlands Heart Foundation.
A consortium grant was also awarded by
the Netherlands Heart Foundation to CARSII; cardiomyopathy Registry Study-II, Dilated
cardiomyopathy in children. Improving
diagnosis by state-of-the art genotyping and
outcome by risk stratification and optimizing
pharmacotherapy, of which Dr Michiel
Dalinghaus is principal investigator ( € 350.000).
PhD candidate Stephanie Lankhorst received
an accommodation grant for the 23rd European
Meeting on Hypertension, which was held
from June 14-17 in Milan. This grant includes
accommodation during the congress and
congress fee. At this meeting she gave an oral
presentation entitled: ‘OPTIMAL TREATMENT OF
HYPERTENSION AND RENAL TOXICITY INDUCED
BY THE ANGIOGENESIS INHIBITOR SUNITINIB’.
PhD candidate Paula Bautista Niño received a
4-year PhD grant from Colciencias, the public
entity that designs, manages and coordinates
the National Policy on Science, Technology and
Innovation in Colombia. This project concerns
a joint collaboration between the departments
of Epidemiology and Internal Medicine/
Pharmacology.
Radiology, department Biomedical Imaging
Professor Wiro Niessen became Executive Director
of the Medical Image Computing and Computer
Assisted Intervention Society (MICCAI).
Professor Eric Sijbrands has been appointed
Raine Professor at the School of Medicine
and Pharmacology, Royal Perth Hospital, Perth
Australia.
Together with Dr. Theo van Walsum (Biomedical
Imaging Group/Radiology), Dr Hans Bosch
obtained a grant of € 627.000 for their IMAGIC
project. This project is part of the STW iMIT
Perspective program, and focuses on image guided
cardiac interventions.
The CVON project Heart-Brain connection
(HBC: the missing link in the pathophysiology
Dr Adrie Verhoeven was elected by the 2nd year
medical students as Teacher of Year 2 for 20122013.
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of vascular cognitive impairment), in which
professor Wiro Niessen, professor Peter Koudstaal
en dr Afran Ikram are principal investigators, was
granted (€ 10.350.000).
Dr Stefan Klein received The Henk Stassen award
for his research in biomedical image registration
during the Dutch Conference on BioMedical
Engineering, January 24/25, 2013, in Egmond aan
Zee. The chairman of the jury was Prof. dr. Frans
van der Helm (TU Delft).
On December 1-6, 2013 at the 2013 RSNA Annual
Meeting in Chicago, Illinois, PhD candidate Raluca
Saru of the department of Radiology received
the Certificate of Merit award for her education
exhibit at the 99th Scientific Assembly and
Annual Meeting of the Radiological Society of
North America. Dr Koen Nieman acquired a ZonMW
Doelmatigheid grant for the CRESCENT II study.
Raluca Saru
Vascular Surgery
Dr Jeroen Essers was invited to give a lecture
at the Gordon Research Conference July 21-26,
in Biddeford ME, USA, with the ‘Consequences
of impaired elastogenesis in Fibulin-4 deficient
mice’.
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Education
PhD Training
June 20 & 21, 2013
Cardiovascular Pharmacology
Coordinators: Professor Jan Danser (Internal
Medicine) and Dr Antoinette Maassen van den
Brink (Internal Medicine)
Number of participants (PhD candidates): 14
COEUR offers PhD candidates a research and
education program tailored towards their
individual requirements. This program aims to
develop their knowledge and skills such that
they can become independent researchers, and
provides them with a broad basis for their future
professional career. Monitoring of the actual
education progress of individual PhD candidates
is now standard practice, and an overview of the
education obtained during the duration of the PhD
program is presented elsewhere in this booklet.
Importantly, the current education program has
received high marks during the re-accreditation in
2009 by the Royal Dutch Science Society (KNAW).
Contents
December 12 & 13, 2013
Cardiovascular Medicine
Coordinators: Professor Frank W Leebeek
(Haematology) and Dr Anton van den Meiracker
(Internal Medicine)
Research Seminars
January 18, 2013
Translational Electrophysiology
Organizers: NMS de Groot (Cardiology) and C Kik
(Cardiothoracic Surgery)
Speakers: Professor M Alessie (CARIM), C Kik,
NMS de Groot, DAMJ Theuns, T Szili-Torok
Number of participants: 20
The curriculum of 2013 comprised the following
courses:
January 10 & 11, 2013
Cardiovascular Imaging and Diagnostics
Coordinators: Professor Aad van der Lugt
(Radiology) and Dr Hans Bosch (Cardiology)
February 22, 2013
Pulmonary-Right ventricle Interaction
Organizers: IKM Reiss (Neonatology) and
D Merkus (Cardiology)
Speakers: IKM Reiss, RJ Rottier, DPM de WijsMeijler, WA Helbing, E Martelli Moreira, D Merkus,
AE van den Bosch
April 25 & 26, 2013
Congenital Heart Disease
Coordinators: Professor Jolien Roos-Hesselink
(Cardiology),
Professor Ad Bogers (Cardiothoracic Surgery) and
Professor Wim Helbing (Paediatrics)
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April 12, 2013
Symposium Careful and integer dealing with
research data
Organizers: H Boersma (Scientific Director COEUR)
and AJM Verhoeven (Secretary COEUR)
Speakers: H Boersma, S van de Vathorst, RE Juttman
(AMC, Pathology), A Karanasos, ASA Autar, MPM
de Maat, Professor H ten Cate (MUMC, Internal
Medicine), MAH Sonneveld, S Uitte de Willege
May 24, 2013
Carotid atherosclerotic plaques: biomechanics and
imaging
Organizers: WJ Niessen (Radiology), A van der Lugt
(Radiology), FJH Gijsen (Biomedical Engineering),
JJ Wentzel (Biomedical Engineering)
Speakers: M Cibis, L Speelman, H Smit, AC van Dijk,
A Arias Lorza, HA Nieuwstadt, M Selwaness
April 19, 2013
Professor Jay W Heinecke, Professor of Diabetes and
Obesity Center, University of Washington, Seattle
WA, USA
Title: HDL’s Protein Cargo: Friend or Foe in
Cardioprotection?
The curriculum of 2013 comprised the following
Lectures:
June 11, 2013
Professor Edward O. McFalls, Chief of Cardiology, VA
Medical Center
Professor of Medicine, University of Minnesota,
Minneapolis, USA
Title: The Hibernating Heart: Will it Ever Awaken?
June 21, 2013
Gender differences in cardiovascular disease
Organizers: JW Roos-Hesselink (Cardiology) and
JE Roeters van Lennep (Internal Medicine)
Speakers: JW Roos- Hesselink, C de Klijn (UMCU,
Neurology), JE Roeters-van Lennep, MPM de Maat,
K Nieman
June 25, 2013
Professor Carsten Wagner, Institute of Physiology,
University of Zürich, Switzerland
Title: Regulated excretion of acid by the kidneys?
October 23, 2013
Professor Jacques Ohayon, Professor of Mechanics,
Laboratory TIMC-IMAG/DyCTiM, UJF, CNRS UMR
5525, In3S, Grenoble, France & Engineering School
Polytech Annecy-Chambéry, University of Savoie, Le
Bourget du Lac, France
November 29, 2013
Coronary and Cranial Thrombosis
Organizers: HMM van Beusekom (Cardiology), E
Regar (Cardiology), MPM de Maat (Hematology)
and DWJ Dippel (Neurology)
Speakers: DWJ Dippel, Professor AC van der Wal
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Aortic Pathology Symposium, April 18,
2013
Bourget du Lac, France
Title: Biomechanics of Atherosclerotic Plaque: Site,
Stability and in vivo Modeling
The second Aortic Pathology Symposium was
organized in the WTC in Rotterdam by Professor
Jolien Roos-Hesselink (Cardiology) together with
the Dr. Jos Bekkers (Cardiothoracic surgery),
Professor Hence Verhagen (Vascular Surgery) and
Dr. Marja Wessels (ErasmusMC, Clinical Genetics).
New insights and actual treatments of aortic
diseases were discussed. The keynote speaker
was Professor Erwin Oechslin from Toronto
General Hospital, who talked about the “Bicuspid
aortic valve”. The symposium was targeted at
cardiologists, heart- and vascular surgeons,
clinical geneticists, and those in training for these
specialisms. The symposium was attended by
more than 100 participants.
Other educational activities
The 18th European symposium on Ultrasound
Contrast Imaging, 17-18 January 2013
An inspiring 18th symposium was organised by
the Scientific Committee, composed of Dr Folkert
ten Cate, Professor Nico de Jong, Dr Arend Schinkel,
Erasmus MC and Dr Edward Leen (Imperial College
London). This conference on the latest development
in contrast echocardiography was attended by
clinicians, engineers and basic scientists from both
academia and industry. The excellent organization
and the small-scale setting allowed for extensive
interaction and lively discussions among
participants. PhD candidates Zeynettin Akkus
and Stijn van den Oord from the departments of
Biomedical Engineering and Cardiology received
the best poster award because of the translational
aspect of their research. They developed software
for semi-automated quantification of intraplaque
neovascularization in carotid atherosclerosis
and validated this in a clinical setting. The prize
included a certificate and a sum of €500.
Erasmus Winter Programme
February 25 – March 15, 2013
Faculty of COEUR actively participated in the
NIHES Erasmus Winter Programme held in the
Erasmus Expo- & Congress Centre, Rotterdam. The
Programme was focused on the basic principles
and methods of clinical research. It included
courses on clinical trials, drug safety research,
biostatistics and in decision making in clinical
medicine. Number of participants: 193
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Minor Medical Delta
In cooperation with the combined Erasmus MC PhD
committee and the other (local) Research Schools,
COEUR participated in the yearly “PhD information
market”, which took place on July 4th. The Research
Schools provided the beginning PhD students
with information of their institutes and education
programs. Last-year PhD students were informed
on thesis printing and career development
strategies. Presentations and workshops were
given on practical PhD issues including ethics and
medical communication and writing.
Several COEUR groups participated in this minor
for physics students from Delft and Leiden.
Medical Delta is a collaboration of the Erasmus
MC, LUMC and the Technical University of
Delft, aimed at the improvement of healthcare
through the development, improvement and
implementation of medical technology. In this 20week minor 40 physics students were introduced
into various aspects of biomedical and clinical
research. In two 2-weeks projects, they worked
in various COEUR groups on solving technical
problems in biomedical applications.
Medical students elective course
In January, the elective course “Introduction into
methodologies and measurements” that includes
an introduction to ECG and echocardiography as
well as acute neurovascular disorders was given
to 30 motivated 2nd year medical students. The
aim of the course is to introduce the students with
current research questions in the Cardiovascular
field, and to learn about the various approaches,
models and methods to address these questions.
In addition, the students have to write a small
systematic review of the literature on a topical
issue within the cardiovascular clinical practice.
PhD-training course “Cardiac Function
and Adaptation”, “Thrombosis and
Haemostasis” and “Vascular Biology”.
September 30 - October 4, 2013
The venue of the course was Papendal, near
Arnhem. The courses are organized under
auspices of and with financial support from the
Netherlands Heart Foundation.
The courses are an integral part of the PhDtraining offered collectively by the Dutch
Cardiovascular Research Institutes including
COEUR. The three courses are taught
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Shear Stress Symposium on
Biomechanics in Vascular Biology and
Cardiovascular Disease
simultaneously, meaning that each student can
participate in only one of the three courses each
year. An important aspect of the courses is the
interaction between PhD students from different
Research Institutes. To this end, assignments were
discussed in small groups and social activities
were planned during the evenings. Participants
also had to present a poster of their own research
project. 12 COEUR PhD candidates attended to this
year’s training course.
In April 2013 the 8th “International symposium
on Biomechanics in Vascular Biology and
Cardiovascular Disease’ was organized in the
Hilton hotel in Rotterdam. The symposium
aimed to bridge the gap between biomechanics,
vascular biology and clinical research in order to
understand more about cardiovascular disease.
A number of internationally renowned speakers
with a clinical/biological or technical background
were invited to discuss this topic for 2 days. The
keynote speakers this year were prof. dr. Peter
Davies, University of Pennsylvania, USA (Atherosusceptibility of the stressed endothelium: In
vivo site-specific cell adaptation) and David
Steinman, University of Toronto, Toronto, Canada
(Geometric risk factors for atherosclerosis: A
30-year-long odyssey), who presented their latest
work. Over 160 participants from academia and
industry from all over Europe and the USA visited
the symposium and more than 78 abstracts (66
posters en 12 oral) were presented. The reactions
of the speakers and the visitors were very positive,
indicating that a symposium of this kind fills an
important need. In forthcoming years the location
of the conference will alternate between the
North-American Continent and Rotterdam, the
Netherlands.
Optics in Cardiology
March 21 and 22, 2013
The second conference for scientists, clinicians
and engineers on Optics in Cardiology was held
in Lantaren/Venster Rotterdam. During this
two-day symposium the latest breakthroughs
in applications of light in cardiovascular
medicine were presented, highlighting clinical,
technological and translational advances in this
fast-moving field.
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COEUR day 2013
The Principal Investigators and senior scientific
staff spent the afternoon debating the future
of the COEUR Research School. The afternoon
sessions for PhD students included a workshop
on communication styles and feedback, delivered
by Louise Mennen, and concluded with 3-minute
presentations by PhD students, explaining
their research projects. The prize for the best
presentation was awarded to Aart Mookhoek,
PhD from the department of Cardio-thoracic
Surgery for his talk “Material Properties of Failing
Pulmonary Autografts”. The breaks were well used
for interaction among the students and staff.
The COEUR day was held on May 31 in the
Netherlands Architecture Institute (NAi). The
day is a continuation of the annual COEUR PhD
day, and was organized together with the PhD
committee. For the first time, this day was not
only meant for PhD students, but also for staff
members, and consisted of plenary sessions in
the morning for all attendants, and separate
sessions for PhD students and staff members in
the afternoon. The aim of the day was to outline
the strengths and capabilities of the various
project groups, in the hope that this will facilitate
collaboration and thereby strengthen research
within COEUR. 46 PhD students and 33 principal
investigators/ senior staff members attended the
program.
The day started off with a general opening
statement from the director of COEUR, Professor
Eric Boersma, followed by a series of short lectures
in which the diversity of COEUR was presented
according to the 3 by 3 matrix. The morning
session concluded with a Poster walk, in which
almost all project groups within COEUR presented
their skills and capabilities, as well as a PhD poster
as an example of those capabilities.
28
PhD Comittee Nienke Duppen, Arna van Engelen, Yvonne Sanders and Kirsten Berk
29
30
COEUR DAY 2013
31
32
33
34
Research
The original six research themes have been
converted in a new, matrix like structure. In the
new approach, biological, pathophysiological
and clinical entities are now dominant, and the
organizational scheme has now moved to the
background. The current structure follows the
example already given in the annual report of
2006, and results from both internal as well as
external recommendations. In the current setup, the following three major themes have been
chosen:
I. Vascular Medicine
II. Acute Cardiovascular Syndromes
III. Chronic Cardiac Disease
Within these three major themes, different
Research Programs haven been created, while the
various disciplines and diseases stages are now on
the vertical axis. The matrix is outlined in more
detail on the following pages, and should provide
much better insight into the various research
activities within COEUR.
35
Discipline
Discipline II
Aetiology
Aetiology &
& Pathogenesis
Pathogenesis
Themes
Themes
Discipline
Discipline IIII
Imaging
Imaging &
& Diagnos
Diagnos
Echo
Echo
Theme
Theme II
Vascular
Vascular Medicine
Medicine
I-A
I-A
Atherosclerosis
Atherosclerosis
MRI
MRI
Molecular
Molecular Biology
Biology
IVUS
IVUS
CAD
CAD im
im
Biomechanics
Biomechanics
Biomechanics
Biomechanics
Periphe
Periphe
Vascular
Vascular Damage
Damage &
& Repair
Repair
I-B
I-B
Disorders
Disorders of
of the
the microcirculation
microcirculation
Role
Role of
of RAAS
RAAS
Ageing
Ageing
Regulation
Regulation of
of Tone
Tone
I-C
I-C
Cardiovascular
Cardiovascular Genetics
Genetics
I-D
I-D
Aneurysm
Aneurysm disease
disease
Genetic
Genetic regulation
regulation of
of vasculo/angiogenesis
vasculo/angiogenesis
Metabolic
Metabolic Diseases
Diseases
Molecular
Molecular biology
biology
Aortic
Aortic imaging
imaging
Genetic
Genetic regulation
regulation
Role
Role of
of RAAS
RAAS
Aortic
Aortic remodeling
remodeling
Theme
Theme IIII
Acute
Acute CV
CV Syndromes
Syndromes
II-A
II-A
Hemostasis
Hemostasis &
& Thrombosis
Thrombosis
Role
Role of
of hemostasis
hemostasis in
in thrombosis
thrombosis
II-B
II-B
Acute
Acute Coronary
Coronary Syndromes
Syndromes
Mechanisms
Mechanisms of
of Plaque
Plaque Vulnerability
Vulnerability
II-C
II-C
Stroke
Stroke &
& Migraine
Migraine
II-D
II-D
Critical
Critical Illness
Illness and
and Sepsis
Sepsis
Theme
Theme III
III
Chronic
Chronic Cardiac
Cardiac Disease
Disease
III-A
III-A
Cardiac
Cardiac Remodeling
Remodeling and
and Failure
Failure
IVUS
IVUS
CAD
CAD im
im
Biomechanics
Biomechanics
Periphe
Periphe
Causes
Causes of
of Stroke
Stroke
Neurovascular
Neurovascular Imaging
Imaging
Pharmacology
Pharmacology of
of migraine
migraine
Microcirculation
Microcirculation
Mechanisms
Mechanisms of
of cardiac
cardiac remodeling
remodeling and
and failure
failure
3D
3D echo
echo
Cardiac
Cardiac Imaging
Imaging
CV
CV Imaging
Imaging &
& DiagnosDiagnostics
tics
Cardiac
Cardiac Imaging
Imaging
Ageing
Ageing
III-B
III-B
Arrhythmias
Arrhythmias
Atrial
Atrial fifibrillation
brillation
III-C
III-C
Congenital
Congenital heart
heart disease
disease
Mechanisms
Mechanisms of
of cardiac
cardiac remodeling
remodeling and
and failure
failure
Cardiac
Cardiac Imaging
Imaging
Cardiogenetics
Cardiogenetics
36
Discipline
Discipline IIII
ging
ging &
& Diagnostics
Diagnostics
maging
aging
MSCT
MSCT
CAD
CAD imaging
imaging
Peripheral imaging
imaging
Peripheral
Discipline
Discipline III
III
Therapy
Therapy &
& Prevention
Prevention
Technology
Technology
Percutaneous
Percutaneous
Interventions
Interventions
Image
Image Processing
Processing
Peripheral Vessels
Vessels
Peripheral
US Transducers
Transducers
US
Stents and
and Restenosis
Restenosis
Stents
US agents
agents
US
CV
CV Surgery
Surgery &
&
Anesthesiology
Anesthesiology
Risk
Risk Stratifi
Stratification
cation &
&
Pharmaco
Pharmaco Therapy
Therapy
Clinical Decision
Decision Making
Making in
in Surgery
Surgery
Clinical
Cardiac Risk
Risk Evaluation
Evaluation and
and Modifi
Modification
cation
Cardiac
CABG
CABG
Role of
of RAAS
RAAS
Role
Pharmacogenomics
Pharmacogenomics
Image processing
processing
Image
Aortic endografts
endografts
Aortic
Medical Manag.
Manag. of
of aneurysm
aneurysm disease
disease
Medical
Molecular imaging
imaging
Molecular
Manag. of
of hemorrhag
hemorrhag &
& thrombc
thrombc disorders
disorders
Manag.
CAD imaging
imaging
CAD
Image Processing
Processing
Image
Peripheral imaging
imaging
Peripheral
US Transducers
Transducers
US
Image Processing
Processing
Image
Primary PCI
PCI for
for AMI
AMI
Primary
Cardioprotection
Cardioprotection
Biomarkers of
of acute
acute coronary
coronary event
event
Biomarkers
Cerebrovasc. Disease
Disease
Cerebrovasc.
Prognosis &
& Clinical
Clinical Manag.
Manag. of
of Stroke
Stroke
Prognosis
Pharmacology of
of migraine
migraine
Pharmacology
Image Processing
Processing
Image
Stem Cell
Cell Therapy
Therapy
Stem
US Transducers
Transducers
US
Heart Transplantation
Transplantation
Heart
Mapping
Mapping
Catheter Ablation
Ablation
Catheter
Image Processing
Processing
Image
Cath Based
Based Int.
Int.
Cath
US Transducers
Transducers
US
37
Assist-Devices
Assist-Devices
ICD Therapy
Therapy Stratifi
Stratific.
c.
ICD
Outcome
Outcome
Themes
Discipline I
Aetiology & Pathogenesis
Theme I
Vascular Medicine
I-A
Atherosclerosis
2,4,5,7
I-B
Disorders of the microcirculation
1,2,8,11
I-C
Cardiovascular Genetics
6,12,24
I-D
Aneurysm disease
Theme II
Acute CV Syndromes
II-A
Hemostasis & Thrombosis
II-B
Acute Coronary Syndromes
II-C
Stroke & Migraine
II-D
Critical Illness and Sepsis
Theme III
Chronic Cardiac Disease
III-A
Cardiac Remodeling and Failure
III-B
Arrhythmias
III-C
Congenital heart disease
Discipli
Imaging & Dia
Di
Echo
MRI
4,5,19
4,2
20
24
24
14,15
1
19
9,13
20
22
3
21
1,2,8,11,12
20,22
17,18
32
30
38
29,32
Discipline II
Imaging & Diagnostics
Discipline III
Therapy & Prevention
RI
MSCT
Technology
Percutaneous
Interventions
CV Surgery &
Anesthesiology
Risk Stratification &
Pharmaco Therapy
2
4,2
16,18,23
2,19,28
31
34,36
3
8,11
0
12
24
20
16,23
2
22
16,23
32
25
24,34
14,15
0
22
24
20,22
19,28
31
10
9,13,22
16,23
2,32
17,2
23,26
16
4,29
39
3,27
10
31
8,11,12,35
23
33
30,35,37
Project 1
Cardiac (mal) adaptation to stress and damage
Ischemic heart disease, in particular myocardial infarction, and hypertension are major causes of heart failure
in western countries. Following myocardial infarction or chronic exposure to pressure-overload, the heart
undergoes extensive alterations in muscle mass and geometry. This cardiac remodeling is associated with an
increased likelihood of progression towards overt heart failure, particularly in the setting of an ageing population.
Research within Project Group 1 is aimed at improving our understanding of the mechanisms underlying the progression from ischemic and hypertensive heart disease towards heart failure in order to identify
novel targets for therapy. For this purpose, our research focuses on the pathogenesis and therapy of (i) acute
myocardial infarction, (ii) the cardiac remodeling and dysfunction that follows in the days-weeks after myocardial infarction and systemic pressure-overload, (iii) myocardial dysfunction and perfusion abnormalities
in post-infarct remodelled myocardium (iiii) pulmonary hypertension secondary to hypoxia, left ventricular
dysfunction or thrombo-embolic events. Furthermore, we study (v) the effects of aging and exercise training
on cardiac remodeling and dysfunction following myocardial infarction and chronic pressure overload and (vi)
the influence of age on the cardiac responses to hemodynamic overload.
Principal Investigators
Co-Investigators
PhD candidates
.
DJGM Duncker, D Merkus
VJ de Beer, A Bogers, C Cheng, AH Danser, RJ van Geuns, IM Heinonen, JH Hoeijmakers,
M van Houwelingen, AH van den Meiracker, KM Reiss, AJM Roks, J Roos- Hesselink, D Tibboel, AJM Verhoeven, F Zijlstra
Name
Subject
GMJ de Boer
Cardiac dysfunction in aging: The role of genomic instability
S Ding
Microvascular function in health and disease
GJ van Essen
Does cardiovascular performance in domestic swine obey allometric scaling laws?
DPM Meijler
Pulmonary hypertension (of the neonate)
Y Octavia
The dual face of endothelial nitric oxide synthases in the different etiology of heart failure
K Stam
Pulmonary Hypertension and associated Right Heart Failure: breaking the vicious circle
YJHJ Taverne
Reactive oxygen species and the endothelium. Friend or foe of the cardiovascular system?
T Yetgin
Effects of ischemic postconditioning and/or glucagon-like-peptide-1 mimetic exenatide on infarct size
40
Project 2
Experimental interventional cardiology, vascular injury and repair
In this project our focus is to study vascular wound healing with a focus on
1) the vascular response to coronary (PCI) and peripheral vascular interventions and
2) treatment strategies and sequellae following experimental “ischemia and reperfusion”.
PCI studies are performed in different species as well as in disease models. We have found that these play
an important role as they significantly affect the response to vascular injury and repair in both coronary and
peripheral arteries. We employ simple models such as direct stenting and balloon angioplasty (injury) prior
to PCI in healthy young animals, but also more complex models such as diet and Diabetes Mellitus induced or
accelerated atherosclerosis. Different imaging modalities (invasive by e.g. OCT, NIRS, IVUS, and non-invasive
by CT or MRI) allow us to characterize the baseline environment and to study the vascular response to drug
eluting stents and scaffolds in a longitudinal setting. In these models we study the pharmacodynamics and
polymer degradation behavior using drug eluting stents and biodegradable scaffolds in different vascular
environments in health and disease.
Ischemia-reperfusion studies, both acute and chronic, are geared towards novel vascular (adjunctive)
therapies for acute myocardial infarction. By means of invasive and non-invasive imaging and histology, we
routinely characterize LV-function, and the composition and geometry of the infarct and no-reflow zones. We
can successfully achieve therapy by means of local drug delivery and post-conditioning strategies. For the
longitudinal studies we have set-up an early and sensitive assay for the determination of baseline infarct size
and no reflow upon reperfusion. In addition and in collaboration with the clinical catheterization laboratory
we are building a biobank of coronary thrombus aspirates (CorTAsk) to aid in understanding no-reflow in the
clinical setting
41
Project 2- continued
HMM van Beusekom, DJGM Duncker, ES Regar
Co-Investigators
AHJ Danser, TM Luider, MPM de Maat, G van Soest, OE Sorop, F Zijlstra
PhD candidates
Name
Subject
ASA Autar
Arterial Thrombosis
N van Ditzhuijzen
Imaging of coronary interventions and early artherosclerosis in a porcine coronary model
M van den Heuvel
Vascular repair in diabetes mellitus
M Kurata
Nettosis in Acute Myocardial Infarction
DB Uitterdijk
Novel therapies for acute myocardial infarction
42
Intracoronary imaging of bioresorbable vascular scaffolds in diabetics:
from experimental to clinical study - Nienke van Ditzhuijzen
The bioresorbable vascular scaffold (BVS) is a recently introduced everolimus-eluting scaffold developed
for the treatment of coronary artery lesions with transient vessel support and drug delivery. BVS allow for
temporary scaffolding of the vessel and therefore potentially enable return of vasomotion, late luminal
enlargement and late expansive remodeling.
The swine coronary artery model is a valuable model for the evaluation of coronary scaffolds
because of the close similarities of the anatomy and physiology of the pig and human hearts. By the
induction of diabetes mellitus and by feeding the swine a high-cholesterol diet, coronary atherosclerosis
similar to that seen in humans can be developed. Scaffolds can be placed in the vascular bed they are
designed for, and serial intracoronary imaging can be performed to allow for detailed long-term evaluation.
This is noteworthy, as intracoronary imaging techniques such as optical coherence tomography (OCT) and
near-infrared spectroscopy (NIRS) have the potential to complement standard histology in the assessment of
the BVS platform by allowing in-vivo serial evaluation of the BVS and the vascular healing response to BVS.
Our group developed an atherosclerotic swine model that closely mimics the clinical situation.1 All swine
were fed a high-cholesterol diet and in half of the swine diabetes mellitus was induced. To evaluate the
vascular healing response to BVS we implanted 32 BVS in 2 of the main epicardial arteries and performed
serial OCT and NIRS imaging at baseline, 3 and 6 months follow-up in all swine.
As a result of our study in swine, we are currently initiating a multi-modality intracoronary imaging study to
evaluate the vascular healing response to BVS in diabetic patients.
Reference:
1. van Ditzhuijzen NS, van den Heuvel M, Sorop O, van Duin RW, Krabbendam-Peters I, van Haeren R,
Ligthart JM, Witberg KT, Duncker DJ, Regar E, van Beusekom HM, van der Giessen WJ. Invasive coronary
imaging in animal models of atherosclerosis. Neth Heart J. 2011;19:442-446
43
Project 3
The circulation, ventilation and ethics during multiple organ failure
Critical illness often results in multiple organ failure. Sepsis is a common source and the syndrome affects
the circulation and ventilation among other vital organ functions. The research around this typical intense
care syndrome is thus programmed around these topics, as can be deducted from the individual projects
enumerated below. Research on the circulation in the syndrome focuses on peripheral perfusion, among others.
New techniques, like side stream dark field (SDF), laser speckle imaging and near-infrared spectroscopy (NIRS)
have been studied for assessing microvascular perfusion in septic patients. In order to minimize inflammatory
response in mechanically ventilated septic patients, a new lung monitoring device (Electrical Impedance
Tomography) is used to optimize ventilator settings. Ultimately, the syndrome can be intractable, raising
ethical issues on end-of life decisions.
44
Project 3 - continued
J Bakker, J van Bommel, DAMPJ Gommers, ABJ Groeneveld,
C Ince, E Kompanje
PhD candidates
Name
Subject
JPC van den Akker
The effect of mechanical ventilation on kidney function
IG Bikker
Optimization of oxygenation and circulation in critically iII patients
P Blankman
Optimizing ventilator settings in order to reduce inflammatory response
M Egal
Acute kidney injury and fluids
J Epker
Palliation of end of life
P van der Geest
De ProBic study and other diagnostics of infection
ME van Genderen
Hemodynamics in the critically ill; Effects on systemic and peripheral perfusion
HRH de Geus
NGAL, The Early Biomarker for AKI
K de Haan
Vitamin D in critical illness
M Helmi
Limiting Lung-Heart Interaction during Mechanical Ventilation
SH Hoeboer
Markers of infection and adverse sequelae
B van der Hoven
Measurement of functional liver blood flow
E Klijn
Microcirculation in critically ill patients
LPB Meijs
Mean systemic filling pressure and heart performance in determining cardiac
performance and fluid balance
C Slagt
The Flotrac: validation and clinical application
S Stads
Predicting initiation and discontinuation of continuous renal replacement therapy
in the critically ill
Z Trogrlic
Improvement of care for ICU patients with delirium by early screening and
treatment
45
Optimizing ventilator settings to reduce inflammatory response - Paul Blankman
Promotor: Diederik Gommers
A large group of patients admitted to the Intensive Care Unit (ICU) require mechanical ventilation. Although
mechanical ventilation is a lifesaving treatment for patients with respiratory failure, it is known that it can
cause or aggravate damage to lung parenchyma leading to Ventilator Induced Lung Injury (VILI). It is difficult
to assess which ventilator settings are optimal for the individual patient at the bedside. Electrical Impedance
Tomography (EIT) can be used as a bedside monitoring tool to visualize the ventilation distribution. We
have previously shown that the optimal PEEP level to keep alveoli open in post-cardiac surgery patients
differs between the upper and lower lung regions as measured by EIT. However, the lower lung regions and
especially the dorsal lung regions are of special interest, because these regions have high risk for atelectasis.
We found that EIT was able to detect the point where lung regions start to get overdistended during the
inspiration. In another study performed in the same group of patients, we compared the effect of Pressure
Controlled Ventilation (PCV) and Pressure Support Ventilation (PSV) on ventilation distribution. During PCV
the mechanical ventilator takes over the respiration of the patient, whereas during PSV the patient has
his own control to start ventilation and the ventilator delivers a preset amount of pressure assist. Because
during PSV the patient uses his diaphragm, more air is then distributed to the better-perfused dorsal
lung regions. This leads to less shunting and alveoli are less at risk to collapse. Thus if we use EIT to titrate
ventilatory settings during PSV, we might reduce the amount of atelectatic lung tissue and thus the stress
on lung parenchyma. This might reduce the risk to develop VILI, which could help to reduce the length of
stay on the ventilator and length of stay at the ICU.
46
47
Project 4
Shear-stress related plaque formation: from bench to bedside to population studies
Shear stress plays an important role in the patho-biology of the endothelium. Among others, it primes the
endothelium for atherosclerotic plaque formation, which can be found at the low and oscillatory shear
stress regions in the vasculature. However, evidence is accumulating for a role of high shear stress in plaque
destabilization. This project focuses on the different (molecular) aspects of the role of low or high shear
stress in the generation and destabilization of vulnerable plaques. For that reason studies are performed
in an established animal model of vulnerable plaque formation as well as in patients that are treated for
pathological lumen obstruction. For those studies a combination of computational fluid dynamics and
advanced catheter based or non-invasive imaging techniques for the assessment of plaque composition is
applied. Using the information from the before described studies, we investigate whether shear stress can
contribute to prediction models of atherosclerotic plaque growth and events in a population based study.
Principal Investigator
JJ Wentzel
Co-Investigators
RJ van Geuns, FJH Gijsen, K van der Heiden, A van der Lugt, ES Regard,
PhD candidates
AFW van der Steen, TH van Walsum, MW Vernooij, GP Zahnd
Name
Subject
M Cibis
Image based wall shear stress measurement
JTC Schrauwen
Fusion of imaging parameters for prediction of plaque rupture in human coronary
arteries
M Selwaness
Association of local biomechanical parameters with vulnerable plaque
development and risk of stroke
LCJ Winkel
Endothelial NOX/ROS contribution to plaque vulnerability
R Xing
Linking biomechanics to the biology of plaque progression: a non-invasive
imaging study
48
Project 5
Biomechanics of the vascular wall
Plaque rupture is in the majority of the cases the underlying cause of cardiovascular events. Plaque rupture
occurs at the locations were the stress exceeds the local plaque strength. Plaques are very heterogeneous
in composition and local tissue strength. However, not much is known on the biomechanical properties
of the different plaque components. In this project we investigate at which pressure and at what location
the plaque would rupture by studying the local stress distribution and deformation of the different plaque
components under increasing loading. Therefore, in an in vitro setup atherosclerotic plaques from patients or
animal models of atherosclerosis are subjected to different pressure loadings and the local deformations are
imaged using advanced imaging techniques. This information will be used to validate computations on stress
distributions in these plaques. Advances will be made in imaging of plaque deformation and (multiscale)
modeling of the different plaque components.
FJH Gijsen, JJ Wentzel
Co-Investigators
M de Bruijne, PJ de Feyter, A van der Lugt, WJ Niessen, PhD candidates
L. Speelman, AFW van der Steen
Name
Subject
ZAM Kassar
Biomechanical stress in Carotid Atherosclerotic Disease
HA Nieuwstadt
Biomechanical Modeling of Carotid Artery Plaque Rupture
49
Project 6
Genetic regulation of vasculogenesis and angiogenesis
In this project, we have performed a genome wide expression to identify new molecular regulators of vessel
formation during development and disease. Using cross species expression profiling we have identified
2000+ genes involved in neoangiogenesis in the mouse, zebrafish and in the cardiac patient. 110 of these
clones were analyzed using in vivo knockdown analysis in the zebrafish larvae. 32 Novel proteins have been
identified that previously were unknown and not associated with new vessel formation. Subsequent studies
analyzed in depth the function of the novel proteins using gain-of-function and loss-of-function analysis in
primary cell cultures, ex vivo vascular complex formation (embryoid body, retina model), and various in vivo
models, to determine the molecular signaling cascade and the function of the proteins in vessel formation in
development and cardiovascular and oncological disease.
Previously, we have been able to describe the role of F-family of Sry-related HMG box transcription factors
in the determination of arteriovenous patterning. Arterial specification was lost in Sox7/Sox18 morphant fish,
as well as in Sox7 and Sox18 knockout zebrafish. In other studies, we have identified new genetic regulators of
vascular pruning of the developing arterial bed, a poorly understood process during which ectopic arterioles
appear to regress (‘arterial pruning’). Currently we are creating knockout mice of several of these newly
identified molecular regulators. In addition, the function of these genetic regulators in human ischemic
disease is studied in human patients with manifest ischemic coronary artery disease.
HJ Duckers
Co-Investigators
DJGM Duncker, JHJ Hoeijmakers, S Schulte-Merker, PW Serruys, F Zijlstra
Postdoc
C Cheng
PhD candidates
Name
Subject
MM Brandt
Molecular Endothelial-Pericyte interaction
PE Burgisser
Genome wide expression analysis in ischemic coronary artery disease patients
I Chrifi
Effect of mural cell-endothelial cell interaction during new vessel formation
RA Haasdijk
Molecular regulation of vasculogenesis and angiogenesis
DMA Hermkens
Genomic regulation of vasculogenesis
IA Panfilov
Stem cells in cardiology
D Tempel
Mouse genomics to identify the genetic regulation of vasculogenisis / angiogenesis
50
Project 7
Molecular biology of atherosclerosis
The molecular regulation of late atherosclerosis and progression into unstable plaques has long eluded
scientists. In patients with cardiovascular disease, endothelial dysfunction due to impaired bioavailability
of Nitric Oxide (NO) is a hallmark and causes impaired vascular remodeling. We have been able to identify
several regulators of plaque destabilization by differential expression analysis in mice, zebrafish and
cardiovascular patients. These genetic factors are mainly involved in microvessel formation in the advanced
atherosclerotic lesion and the associated inflammation of the plaque. Identified clones have been shown
to regulate microvessel formation, the regulation of capillary permeability (arterial leakage) and vessel
maturation. Whereas some genetic regulators have been shown to promote plaque stability by stimulation
of neoangiogenesis via maturation of the capillary plexus and control of the vascular permeability (Hmox1),
others have been shown to both promote local inflammatory processes and vessel permeabilisation (Ets1/
Ets2) resulting in overt plaque destabilization.
Also, we are currently developing a rabbit vulnerable plaque model using the Watanabe hyperlipidaemic
rabbit model, as well as a rupture-prone vulnerable plaque model using a crossbreed of ApoE knockout mice,
with a recently created knockout model of one of our identified vasculogenic candidate genes. In the near
future the combination of stem cell therapy and eNOS gene targeting could lead towards a successful therapy
to repair and stimulate vascular remodeling in patients with cardiovascular disease.
HJ Duckers
Co-Investigators
C Cheng, DJGM Duncker, F Grosveld, J Laman, W Serruys
PhD candidate
Name
Subject
WK den Dekker
Molecular mechanism of the vulnerable plaque
51
Project 8
Hypertension, the kidney and vascular ageing: focus on the renin-angiotensinaldosterone system
This project focuses on hypertension, capitalizing on four pathways to discover novel intervention pathways,
namely:
- the role of aldosterone in difficult-to-treat hypertensive subjects,
- hypertension induced by angiogenesis inhibition in patients with cancer,
- the impact of genomic instability on hypertension, and vascular and renal function, and
- the regulation of volume and osmoregulation in kidneys by WNKs and exosomes
An important unifying aspect in all the above topics, apart from the common relationship with hypertension,
is the involvement of the renin-angiotensin-aldosterone system (RAAS), resulting in projects that investigate
angiotensin/aldosterone interaction in the kidney, the function of the (pro)renin receptor in intercalated cells,
the vasodilator effects of endothelial angiotensin II type 2 receptors (with an emphasis on gender-related
aspects), the angiotensin-(1-7) / Mas receptor axis, the non-genomic effects of aldosterone in the vessel wall,
and the role of RAAS- and related interventions on genomic instability-related vascular and renal dysfunction.
The studies concerning genomic instability involve transgenic mice with decreased DNA repair function, and
are performed in close collaboration with the Departments of Genetics and of Vascular Surgery. Studies on
the importance of nucleotide phosphodiesterases in ageing occur in collaboration with the Department of
Epidemiology.
52
Hypertension, the kidney and vascular ageing: focus on the renin-angiotensinaldosterone system
AHJ Danser, EJ Hoorn, AH van den Meiracker, AJM Roks, R Zietse
Co-Investigators
A Dheghan, DJGM Duncker, J Essers, OH Franco, JHJ Hoeijmakers, GJ van der Horst,
M Kavousi, I van der Pluijm
Postdocs
WW Batenburg, JHM van Esch
PhD candidates
Name
Subject
P Bautista Niño
Cyclic nucleotide phosphodiesterases in vascular aging
S Lankhorst
Hypertension and vascular and renal dysfunction induced by angiogenesis-inhibition: on
search for underlying mechanisms
X Lu
Ion transport in cardiovascular (patho)physiology
AD Moes
When salt turns sour: from kidney salt transport to hypertension
LCW Roksnoer
Urinary biomarkers in humans and rats: focus on diabetes and aldosteronism
M Salih
Exosomal research on ADPKD
B Seva Pessoa
Cyclic Angiotensin-(1-7), a new tool for treatment of heart failure
D Severs
The immune system and sodium balance
K Verdonk
The role of the (pro)rennin-angiotensin system in preeclampsia
H Wu
Vascular DNA protection by G protein-coupled receptor stimulation
53
Hypertension, the kidney and vascular ageing: focus on the reninangiotensin-aldosterone system
PhD project: “When salt turns sour: from kidney salt transport to
hypertension” - Arthur Moes
Hypertension remains one of the major cardiovascular risk factors affecting approximately one third of the
adult population. The role of the immune system in the development of hypertension has gained increasing
attention in recent years. More specific, adoptive transfer studies in mice have shown that the presence of
T but not B cells is required for a complete hypertensive response (Guzik et al., J Exp Med 2007). The mechanism by which T-cells control blood pressure regulation, however, is unknown.
We induced a salt-sensitive form of hypertension in Sprague-Dawley rats using deoxycorticosterone
acetate (DOCA), a precursor of aldosterone. To do so, we implanted a subcutaneous DOCA-pellet in sixteen
Sprague-Dawley rats and provided them with 0.9% sodium chloride to drink. One group was also treated
with mycophenolate mofetil (MMF), an immunosuppressive drug inhibiting T and B cells, while the other
group received vehicle. To measure the blood pressure response, half of the animals in each group received
a telemetry transmitter via a catheter in the abdominal aorta. The experiment lasted for four weeks after
which kidneys and blood vessels were collected for analysis. Vascular reactivity was analyzed with Mulvany
Myographs, using iliac and mesenteric arteries. Baseline mean arterial blood pressure (MAP) was 97 ± 6 mm
Hg in the vehicle-group and 97 ± 6 mm Hg in the MMF-group . In both groups DOCA in combination with
sodium chloride increased MAP, but this increase was significantly attenuated in the MMF-group. The final
MAP in the vehicle-group measured 126 ± 14 mm Hg versus 107 ± 7 mm Hg in the MMF-group (P < 0.001 by
two-way ANOVA). We are currently analyzing the systemic renin-angiotensin system, vascular reactivity, kidney salt-transporters and tissue T-cell invasion to analyze the mechanism of the anti-hypertensive response
of MMF. We anticipate that these insights will increase our understanding of the role of the immune system
in the development of hypertension, and may contribute to finding novel therapeutic targets.
Department of Nephrology
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55
Project 9
Pharmacology of migraine
Migraine is a paroxysmal neurovascular disorder, which is 2-3 times more prevalent in women than in men.
Currently available drugs for the acute treatment of migraine all constrict cranial blood vessels, which most
likely mediates their therapeutic action. However, since these drugs may also constrict peripheral blood
vessels, including the coronary artery, there is concern about cardiac side effects and these drugs are thus
contraindicated in patients with cardiovascular disease. We are investigating the neurovascular properties of
prospective antimigraine drugs that may act via a primary neuronal mechanism. This could result in a reduced
coronary side-effect potential of these prospective drugs. Further, since migraine occurs more often in women
and depends on hormonal fluctuations such as occurring around the menstruation, we investigate the effects
of (changing levels of) female sex hormones on mechanisms implied in the pathophysiology of migraine.
A Maassen van den Brink
Co-Investigators
AJJC Bogers, AJ van den Bogaerdt, AHJ Danser, CMF Dirven, AG Uitterlinden
Postdoc
KY Chan
PhD candidates
Name
Subject
K Ibrahimi
Migraine and female sex hormones: a clinical approach
S Korremans-Labruijere
Migraine and female sex hormones: a focus on epigenetics
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Project 10
Acute coronary syndromes and heart failure
Current research addresses the detection and management of heart failure and cardiogenic shock in patients
with acute coronary syndromes (myocardial infarction). Of particular interest is the microcirculation in
relation to acute heart failure and shock, and how microcirculation and prognosis by specific interventions
can be improved. Furthermore the implications of cardiomyopathies are investigated.
KM Akkerhuis, H Boersma, K Nieman, ML Simoons
PhD candidate
Name
Subject
L Jewbali
Novel treatment strategies in heartfailure: extracorporal life support systems and assist
devices
57
Project 11
Cardiovascular aging
The study of the structural and functional age-related vascular changes represents a good model to unravel
the complex process of senescence.
We investigate mainly three items:
• The environmental and genetic determinants of vascular aging.
• The consequences of vascular aging on short and long term blood pressure regulation.
• The consequence of vascular aging on morbidity and mortality and its possible role in
cardiovascular risk stratification.
These investigations are performed within several settings, in the general population but also in specific
categories of patients including persons with end stage renal disease and with a history of syncope and
patients with first signs and symptoms of dementia.
FUS Mattace Raso
Co-Investigators
AH van den Meiracker, JCM Witteman
PhD candidate
Name
Subject
GC Verwoert
Genetics of hypertension and arterial stiffness
58
Project 12
Cardiovascular genetics and metabolic diseases
At the Erasmus outpatient clinic for cardiovascular genetics, family based approaches are employed to
study inherited cardiovascular diseases: cardiomyopathies, congenital heart malformations, arrhythmias,
dyslipidemias, diabetes mellitus, hypertension and severe premature coronary artery disease.
Technical innovation is a hall mark of this research: for example, novel imaging modalities are used to
identify new phenotypes and high-throughput molecular analyses are performed to identify modifier genes
in addition to major locus effects.
We have identified a large number of novel genes that are associated with cardiovascular disease and
related traits. We perform molecular and biochemical studies to get a better understanding of the mechanisms
underlying the diseases and the complications.
Our clinical research is performed in patients with very rare diseases, like ßβ-myosin heavy chain defects in
noncompaction cardiomyopathy, but also more common disorders of synthesis and processing of insulin in
families with type 2 diabetes.
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Cardiovascular genetics and metabolic diseases
EJG Sijbrands, F Zijlstra
Co-Investigators
FJ ten Cate, CM van Duijn, ECH Friesema, FUS Mattace Raso, M Michels, MT Mulder, JE Roeters van Lennep, FWM de Rooij, JW Roos-Hesselink, AFL Schinkel, AG Uitterlinden, AJM Verhoeven, MW Wessels
PhD candidates
Name
Subject
KAC Berk
Cognitive behavioral therapy after very low calorie diet in overweight patients with type 2
diabetes
S Bos
Improvement of risk stratification in patients with familial dyslipidaemia
Th Geragotou
Beta-cell function in metabolic syndrome and type 2 diabetes
TTW van Herpt
Genetic and Environmental Risk Factors of Type 2 Diabetes
S Jainandunsing
Pancreatic beta-cell function and type 2 diabetes
GL ten Kate
Vava vasorum neovascularisation in type 2 diabetes
FPJ Karstens
Modifying factors of Pompe’s disease
RFH Lemmers
HDL and vascular complications in Diabetes Mellitus type 2
B Özcan
Glycemic control in type 2 diabetes
RGM Timmermans
Complications and treatment of MPS1
R Vongpromek
Lipid composition in heart and brain diseases
PA Vriesendorp
Risk stratification in hypertrophic cardiomyopahty
R Yahya
Novel diagnostic test to improve CVD risk reduction in subjects with DMII, increasing cost
effectiveness and quality of life
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Project 13
Stroke: risk factors and etiology, prognosis and treatment
Stroke is a heterogeneous disease; it comprises ischemic stroke, intracerebral hemorrhage and subarachnoid
hemorrhage. Stroke is a high ranking cause of death and the most common cause of acquired disability in
The Netherlands and Western Europe. Causes of disability include motor dysfunction and disturbances of
language, memory and cognition.
Etiologic studies include genetics (Metabochip), hemostasis (von Willebrand factor, fibrinogen), glucose
metabolism, cardioembolic disorders, and carotid plaque morphology (PARISK).
Intervention studies include a series of multicenter RCT’s of the effect of prevention of high body
temperature and fever (PAIS). Also, we conduct a large national multicenter study of the effect of intraarterial treatment for acute ischemic stroke (MR CLEAN). Furthermore, we evaluate early cognitive linguistic
treatment of aphasia in a series of multicenter RCT’s (RATS) and the value of functional imaging (FIAT) in
patients with aphasia caused by stroke.
Data for genetic, prognostic and etiologic studies are derived from the Erasmus Stroke Study, an ongoing
hospital based registry, and from the Rotterdam study, a large population based cohort study.
Co-Investigators
PhD candidates
DWJ Dippel, PJ Koudstaal
CM van Duijn, MH den Hertog, MA Ikram, F van Kooten, LML de Lau, FWG Leebeek,
HF Lingsma, A van der Lugt, MPM de Maat, M Smits, EW Steyerberg, EJG Sijbrands,
MW Vernooij, EG Visch-Brink
Name
Subject
D Beumer
Study of hemostatic parameters and intra arterial treatment in acute ischemic stroke
(SMARTIS)
RFAG de Bruijn
Genetic and non-genetic causes of dementia
S Fonville
Impaired glucose tolerance and stroke
PSS Fransen
Mr Clean
L Khajeh
Hypopituitarism in patients after subarachnoid hemorrhage: screening and treatment
CP Mendez-Orellana
Mechanism of language recovery after brain damage
F Nouwens
A comparison of radiofrequency and cryotheraphy for ablation
E Osei
Prediabetes in patients with a TIA or minor stroke
IR de Ridder
Paracetamol and stroke
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Project 14
Management of hemorrhagic and thrombotic disorders
Clinical studies on bleeding disorders, including von Willebrand disease are currently performed within this
theme. The Willebrand in the Netherlands (WiN) study is a nation-wide study coordinated by the ErasmusMC
(PI Prof dr Frank W.G. Leebeek) on the clinical aspects of von Willebrand disease. In this study more than 800
patients with moderate and severe VWD are included. We have studied the impact of the disease on quality of
life and obtained more insight in diagnosis and disease burden. In addition we focus on optimal treatment of
this bleeding disorder. In the future we will focus on the genotype-phenotype association.
The etiology, diagnosis and treatment of various clinical entities of venous thrombosis are also focus of
our research. One of our interests is the site specificity of venous thrombosis, for instance hepatic and portal
vein thrombosis. In collaboration with other partners we have initiated studies on prevention and treatment
of arterial and venous thrombosis using new oral anticoagulant drugs, including direct factor IIa and Xa
inhibitors.
FWG Leebeek, MJHA Kruip, MH Cnossen
Co-Investigators
MPM de Maat, DC Rijken
PhD candidates
Name
Subject
JS Biedermann
Treatment with anticoagulants
HCAM Hazendonk
OPTI-CLOT: Peri-Operative PharmacokineTIc-guided dosing of CLOTting factor in hemophilia
YV Sanders
Moderate and Severe Von Willebrand Disease in the Netherlands
SCM Stoof
Optimization of treatment of inherited bleeding disorders
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Project 15
Role of hemostasis in arterial thrombosis
The studies performed in this theme are focusing on the role of coagulation factors and platelets in the
development of arterial thrombosis. Several case-control studies have been initiated to investigate the role of
hemostatic or inflammatory factors in determining the risk of first and recurrent arterial thrombotic events,
including stroke and acute coronary syndrome. Our special interest is on von Willebrand factor and fibrinolysis.
Several genetic approaches are used, including GWAS, SNP and haplotype analysis. We have obtained more
insight in the mechanism of fibrin formation and fibrinolysis by identifying new proteins binding to fibrin
using plasma proteomics techniques. In the coming years we will also focus on the role of alpha2-antiplasmin
in arterial thrombosis. The effect of fibrin structure on the risk of thrombosis and the relationship with
atherosclerosis and angiogenesis, is studied using recombinant and plasma-purified fibrinogen forms.
FWG Leebeek, MPM de Maat, DC Rijken
Co-Investigators
JW Deckers, DWJ Dippel, PJ Koudstaal
Post-doc
S Uitte de Willige
PhD candidates
Name
Subject
S Abdul
Regulation of fibrinolysis by alpha-2-antiplasmin
MAH Sonneveld
Von Willebrand factor, atherosclerosis, and stroke risk
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Role of hemostasis in arterial thrombosis
Von Willebrand Factor, ADAMTS13 and arterial thrombosis - Michelle Sonneveld
Arterial thrombosis is associated with a high mortality and morbidity in the Western world. Currently, there
are many risk factors known for arterial thrombosis, including a number of coagulation factors. My project
focuses on the role of von Willebrand Factor (VWF) and ADAMTS13 in the pathogenesis of arterial thrombosis, including myocardial infarction and ischemic stroke. VWF plays an important role in the hemostasis by
mediating platelet adhesion and aggregation. Large VWF multimers are cleaved by ADAMTS13 into smaller,
less thrombotic forms. We have previously shown that high VWF plasma levels are associated with an
increased risk of arterial thrombosis. In the current studies, we want to elucidate the mechanism by which
VWF increases the risk of AMI and stroke. Firstly, we studied VWF in relation to atherosclerosis and observed
an association between high VWF levels and the extent of atherosclerosis in patients with ischemic stroke.
This indicates that VWF is related to atherosclerosis, but it is still unclear whether VWF plays a causal role
or whether VWF levels are mainly a marker of endothelial dysfunction. Furthermore, we are investigating
whether high VWF levels are associated with an increased risk of cardiovascular mortality.
We also investigate in the Rotterdam Study whether low ADAMTS13 levels are associated with AMI and
ischemic stroke, because low ADAMTS13 will give an increase in the prothrombotic high molecular weight
VWF multimers. We are the first to study the role of ADAMTS13 in arterial thrombosis in a prospective cohort. When ADAMTS13 plays a role in ischemic stroke, it may provide a basis for the use of rhADAMTS13 as
therapeutic option in patients with a recent ischemic stroke
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65
Project 16
Ultrasound contrast agents
Ultrasound contrast agents consist of gas microbubbles (1 – 10 µm) that are coated by a protein, lipid or
polymer. In addition to their diagnostic value, microbubbles have great potential as local drug delivery systems.
In project 16 we investigate the clinical and the more fundamental/ future use of UCA.
The clinical use includes the left ventricle opacification and myocardial perfusion during normal and
stress echocardiography. Further, a clinical study (ParisK) is running to detect the presence and properties of
atherosclerotic plaques in the carotid artery after administration of UCA.
Future use of UCA lies in molecular ultrasonic imaging uses tiny microbubbles that bind to cellular disease
processes. These microbubbles can be functionalized using specific ligands and injected into the human
body. Upon excitation by an appropriate ultrasonic field the microbubbles start to vibrate thereby acting as
an ultrasound source. This source shows a very specific signature which differs to a great extent from the
scattering by normal/pathological tissue. For therapy the bubble can be either loaded with the drug of choice
where the drug can be locally released upon ultrasound and/or the vibrating bubble is used to enhance the
uptake of the drug. Essential in this whole process is the knowledge of the vibrating bubble, the ultrasound
field and the imaging capabilities of the ultrasound system.
Principal Investigator N de Jong
Co-Investigators AFL Schinkel, FJ ten Cate, AFW van der Steen
Postdocs
K Kooiman, GGJ Renaud
PhD candidates
Name
Subject
TJA Kokhuis
Directing adipose derived stem cells to the area at risk in the heart after myocardial
infarction using targeted microbubbles. Development of a new molecular therapeutic
technique
Y Luan
Sonodrugs
SCH van den Oord
Contrast enhanced ultrasound imaging of the vasa vasorum
T van Rooij
Molecular Ultrasound Imaging
IV Skachkov
Sonodrugs
66
Project 17
Echocardiography: Transducers and image processing
Research focuses on novel ultrasound transducers and image processing for ultrasound, with a strong accent
on novel 3D cardiovascular imaging. This includes matrix transducers, electronics and new beamforming for 2D
and 3D imaging of the heart, the carotid artery, the bladder etc. Moreover, image processing approaches for 3D
image generation, 2D and 3D image analysis and quantification by segmentation, tracking and classification
are pursued. Advanced geometric and statistical modeling is employed. Current applications include improved
realtime 3D TEE imaging, 3D echocardiography analysis, stress echo, analysis of plaque vulnerability in carotid
arteries, and monitoring of electrophysiological interventions with 3D ultrasound.
JG Bosch, N de Jong, AFW van der Steen
Co-Investigators
C Lancée, A van der Lugt, T Szili-Torok
Postdoc GGJ Renaud
PhD candidates
Name
Subject
Z Akkus
The Assessment of Plaque at RISK
V Daeichin
Targeted imaging of microvessels using ultrasound
A Haak
Integration of 3D ultrasound into electrophysiology for support of ablation procedures
D Koeze
Intelligent image guidance in cardiac interventions
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Project 18
Intravascular ultrasound techniques
Intravascular imaging is momentarily highly focusing on characterizing the composition of the atherosclerotic
plaque. Charactering lipid content, plaque vascularization and thickness of thin caps are of particular interest.
These characteristics discriminate a stable plaque from a rupture prone or vulnerable plaque. The latter one
can cause myocardial infarctions or stroke. Plaque vascularization is measured by intravascular ultrasound in
combination with ultrasound contrast agents. Several strategies are developed to characterize lipid content.
These are based on optical coherence tomography or combination catheters where light and sound are
combined.
Principal Investigator Co-Investigators
Postdoc
AFW van der Steen
G van Soest, ES Regar, PW Serruys
M Emmer
PhD candidates
Name
Subject
M Gnanadesigan
Tissue characterization of the atherosclerotic plaque using optical coherence tomography
J Janjic
Image-guided Interventions and Therapy-Chronic Total Occlusions (IGIT-CTO)
PK Kruizinga
Photoacoustic imaging of the carotid artery
T Wang
Development of a high speed OCT cathether and imaging system
M Wu
Intravascular photoacoustic imaging
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Project 19
Intravascular imaging and interventional cardiology
The decision making process for patients with obstructive coronary artery disease requiring revascularization
is evolving. Historically, patients with the most complex coronary artery disease were preferentially treated
by surgical revascularization: however technological advances in percutaneous therapy have ensured that
many of these patients can now receive equally effective treatment with percutaneous coronary intervention
(PCI). Intertwined with these developments are a lower threshold to investigate patients with symptoms
suggestive of coronary artery disease, an increasingly elderly population in need of revascularization, the
changing dynamics of the doctor-patient relationship, and a greater emphasis on guideline driven patient
care. Consequently decisions regarding revascularization are now more complex than ever before.
The advent of drug eluting stents (DES), which consist of a drug (immunosuppressive or antiproliferative
drug), a polymer and a metallic platform, has revolutionized the practice of interventional cardiology by
significantly reducing the rates of restenosis and repeat revascularization as compared to bare metal stents.
Within this project, this subject is studied in detail while taking into account evolvement in stent development,
as well as secular trends in acute and chronic benefits of percutanuous coronary interventions.
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Intravascular imaging and interventional cardiology
PW Serruys
Co-Investigators
H Boersma, RT van Domburg, HJ Duckers, PJ de Feyter, RJM van Geuns,
PPT de Jaegere, ES Regar, CJ Schultz, AFW van der Steen, F Zijlstra
PhD candidates
Name
Subject
CAC Campos
Imaging in Interventional Cardiology
RD Diletti
Coronary Artery Atherosclerosis and Restoration Therapy in Bioresorbable Vascular Scaffold Era
V Farooq
Bioabsorbable coronary stents
CHD Girasis
Prognostic Impact of Left Main Coronary Artery Anatomy
BDG Gogas
Invasive Imaging of High risk atheromatous plaques
JL Gutierrez-Chico
In vivo evaluation of neointimal healing after stenting with optical coherence tomography
A Karanasos
Optical coherence tomography for guiding coronary interventions and assesing the vascular
healing response after coronary stent implantation
MM Magro
Percutaneous coronary intervention in high risk patients and complex lesions
T Muramatsu
Multi-modality imaging assessment of complex coronary lesions and bioresorbable scaffolds
Y Onuma
Novel technology in coronary intervention and coronary stents
L Räber
From early to newer generation drug-eluting stents
M Radu
Optical coherence tomography-Methodological considerations and clinical application
G Sarno
Coronary Imaging
C Simsek
The long-term follow-up of drug-eluting stent
JB van der Sijde
Retrospective analysis of the Thoraxcenter OCT data on the impact on stent procedure and
outcome
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Project 20
Cardiac Imaging (MRI and CT)
The advanced cardiac imaging group is a joint initiative by the departments of cardiology and radiology and
collaborates with several (pre-) clinical departments within the Erasmus MC. In 2013 research activities included
assessment of several technological innovations and new clinical applications, i.e. various scan protocols to
reduce radiation exposure, computational fluid dynamics and stress myocardial perfusion imaging to assess the
hemodynamic significance of obstructive coronary disease. Ongoing investigation into the implementation of
cardiac CT in clinical practice includes the use of cardiac CT in patients with stable angina (fast-track chest pain
clinic), to exclude coronary disease in patients with congestive heart failure, and as a tool for triage of acute chest
pain in the emergency ward. Also the potential role of cardiac CT in high-risk populations, including patients
with familial hypercholesterolemia and diabetes, is being explored. The incremental value of CT imaging prior
to valvular and coronary interventions is being investigated. The cardiac MRI imaging PhD candidates focus on
myocardial imaging investigating the acute and chronic damage due to myocardial infarctions. In acute imaging
new techniques to investigate the reversible damage in the area at risk are explored as well as the effect of
microvascular obstruction on long-term remodelling and clinical outcome. Late imaging includes research
into new possibilities for fibrosis imaging (Myocardial T1-mapping) which, if successful, can also be applied on
different cardiac disease where myocardial fibrosis plays an important role.
PJ de Feyter, RJM van Geuns, K Nieman
Co-Investigators
M Dijkshoorn, MGM Hunink, A Kono, G Kotek, A Kurata, A Moelker,
WJ Niessen, M Ouhlous, JW Roos-Hesselink, CJ Schultz, PA Wielopolski
PhD candidates
Name
Subject
A Coenen
Imaging in advance coronary artery disease
A Dedic
Clinical application of competed coronary angiography
AS Dharampal
Cardiac CT
GJR ten Kate
Imaging of coronary arteries by MSCT
M van Kranenburg
CMR of acute myocardial infarction
MM Lubbers
Clinical implementation of cardiac CT
SL Papadopoulou
Coronary atherosclerotic plaque imaging with MSCT
R Saru
Advanced MRI techniques
T Springeling
Acute myocardial infarction and MRI
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Project 21
Cardiac imaging (ultrasound)
Echocardiography is one of the most important diagnostic tools in cardiology. Recent advances in ultrasound
hardware and software have made 3-dimensional echocardiography and speckle tracking echocardiography
possible. These techniques are used for estimation of left ventricular pump function according to the classically
defined volumes and ejection fractions but also deformation and rotation. Newer developments are
1) 3D trans-oesophageal echo,
2) Imaging of the vasa vasorum and
3) Plane-wave imaging.
ML Geleijnse
PhD candidates
Name
Subject
F Kauer
Speckle Tracking Echocardiography in hypertrophic cardiomyopathy
B Ren
3D quantification of mitral & tricuspid valve
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Project 22
Neurovascular imaging (MRI and CT)
Ischemic cerebral infarcts are related to the presence of atherosclerotic disease in the carotid artery. Severity
of the stenosis is a predictor of clinical symptoms and is used as parameter in the therapeutic decision as to
which patients will benefit from carotid intervention. Next to stenosis , plaque morphology is thought to be a
major determinant of cerebrovascular events.
Within this project, imaging of the atherosclerotic plaque in the carotid bifurcation with multidetector
CT and MRI is evaluated. We focus on 1) the validation of imaging parameters by comparison of images with
histology, 2) development of new structural and haemodynamic parameters of atherosclerortic disease, 3)
development and validation of automated measurements, 4) prospective studies in patients and healthy
volunteers to prove the additional value of plaque parameters in risk prediction, 5) Serial imaging studies
to evaluate the natural course of the atherosclerotic disease, 6) Studies into the relationship between
atherosclerotic plaque parameters and brain infarcts and white matter lesions on CT and MRI.
A van der Lugt
Co-Investigators
DWJ Dippel, PJ Koudstaal, GP Krestin, WJ Niessen, HJ Verhagen,
MW Vernooij, CM Witteman
PhD candidates
Name
Subject
MJ Berghout- van Gils
Serial CT Angiography of atherosclerotic carotid plaque: determinants and
prognosis of change in volume composition and morphology
QJA van den Bouwhuijsen
The predictive value of vulnerable plaques in the carotid arteries for risk of
coronary heart disease and stroke
AC van Dijk
Imaging atherosclerotic plaque in ischemic stroke
PJ Homburg
Atherosclerotic plaque characterization with CT angiography
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Project 23
Image processing (cardiovascular)
Cardiovascular imaging has gone beyond the traditional depiction of vascular luminal morphology. Stateof-the art imaging techniques have the potential to provide detailed information on the vessel wall, such as
plaque composition, elastic wall properties, and even biochemical processes that take place in the plaque.
In addition, dynamic and perfusion imaging can provide functional information, e.g. for determining the
perfusion or motion of the heart, or to study tumor activity. Owing to the growing complexity and sheer size
of cardiovascular data, in combination with the large increase in the number of studies in clinical practice
and biomedical research, there is a strong and increasing interest in robust, automated processing tools to
aid in the analysis of these data. This research line aims to develop and evaluate novel image processing
techniques for visualization, quantification, and integrated analysis of multimodal anatomical and functional
cardiovascular imaging data.
WJ Niessen
Co-Investigators
M de Bruijne, PJ de Feyter, RJM van Geuns, S Klein, G Kotek, GP Krestin, A van der Lugt, AFW van der Steen, Th van Walsum, JJ Wentzel
PhD candidates
Name
Subject
A Arias Lorza
Image analysis of the carotid artery for assessment of biomechanical stress on
atherosclerotic plaques
D Dias Bispo Carvalho
Image registration for the analysis of atherosclerotic plaque
G Dibildox
Computer Aided Image Guidance for Percutaneous Treatment of Coronary Chronic Total
Occlusions
A van Engelen
Multimodal image quantification and risk assessment of carotid atherosclerotic plaque
EMM Santos
Automated Intracranial Thrombus Quantification and Characterization in Computed
Tomography
H Smit
Automated carotid plaque analysis from quantitative MR Imaging
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Image processing (cardiovascular)
Multimodal image registration of carotid arteries - Diego Carvalho
The goal is to establish correlations between different images, allowing an improved analysis of atherosclerotic arteries.
The challenging aspects in the MR (Magnetic Resonance) and free-hand sweep three-dimensional
Ultrasound (US) registration are the differences in the image intensities, and in the position of the patient's
neck during the examination. In order to calculate spatial transformations to align the images, geometrical
and intensity information were used. The lumen centerlines were considered as geometrical landmarks
that provide reliable information about the changes in the carotid position. The centerline positions
were combined with the image intensity to achieve a rigid and a consecutive non-rigid registration. On
the experiments, images of 6 healthy volunteers and 5 diseased patients were used. The validation was
performed by calculating the overlap between the segmentation of the arterial lumen in the reference
image (US) and the registered image (MR). The average overlap for the patients and volunteers dataset was
around 0.70.
Registrations were also performed in two-dimensional longitudinal US sequences. These images contain
time frames of side-by-side Bmode US
(BMUS) and Contrast Enhanced US (CEUS). CEUS allows a clear delineation of the arterial lumen, which
can be difficult to define in BMUS. The main objective is to compensate the motion across time, performing
transformations in order that the pixel intensities tend to be constant across the time frames. The motion
tracked by the registration was compared against the average of manual trackings performed by three observers in 150 frames in 11 carotids. The root mean square error in this comparison was around one pixel.
By averaging the intensities of the registered images on all time frames, we obtained images with improved
Signal-to-noise ratio. These images are being used in another algorithm to develop accurate lumen and
plaque segmentations.
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Project 24
Molecular biology of aneurysm formation
In the basic research line ‘Molecular biology of aneurysm formation‘ of the Laboratory for Experimental Vascular
Surgery (LEVAS), the molecular processes that underlie aneurysm formation are investigated through close
collaboration between the department of Genetics & Cell Biology and the department of Vascular Surgery.
The goal of this translational research line is to decrease aneurysm related mortality and reduce the need
for surgical intervention. Consequently, we focus on two research areas: 1) early detection of degenerative
changes in the aortic wall, and 2) pharmacological intervention to treat aortic wall degeneration. To this
end we make use of the scientific expertise and state-of-the-art infrastructure of our research institute as
well as the practical implications, anonymous patient data and bio-bank of the clinical research group. This
intensive collaboration ensures innovative basic research based on clear clinical relevance. This research line is
embedded in the Erasmus MC research schools Medical Genetics Centre South-West Netherlands (MGC) and
COEUR in collaboration with among others the departments of pharmacology, cardiology, clinical genetics,
bioinformatics and biochemistry.
J Essers
Co-Investigators
AH Danser, DJGM Duncker, R Kanaar, D Majoor-Krakauer, JW Roos-Hesselink,
EV Rouwet, PJ van der Spek, HJM Verhagen, MW Wessels, WFJ van IJcken
Postdocs
ED van Deel, I van der Pluijm
PhD candidates
Name
Subject
NWM Ramnath
Aortic aneurysms, from bench to bedside
L te Riet
Dilating versus stenosing arterial disease; identification of the genetic factors involved in
aortic aneurysm formation
BS van Thiel
Characterization of aortic aneurysm disease and the development of therapeutic strategies
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Molecular biology of aneurysm formation
PhD project Pharmacological intervention of the angiotensin II-TGFß-axis in aneurysms
and the identification of genetic factors involved in aortic aneurysm formation Luuk te Riet
Thoracic aortic aneurysms (TAAs) are a potential life-threatening disease with limited pharmacological treatment options. Current treatment options are aimed at lowering aortic hemodynamic stress, predominantly
with βß-adrenoceptor blockers. Increasing evidence supports a role for the renin-angiotensin system (RAS)
in aneurysm development. RAS blockade would not only lower blood pressure, but might also target the
angiotensin II-transforming growth factor-β ß(TGFßβ)-axis in aneurysm formation, resulting in less TGFßβ- and
extracellular signal-regulated kinase 1/2-signaling.
Transgenic mice with a 4-fold (Fibulin-4R/R) reduced expression of Fibulin-4 display the histological features of cystic media degeneration as seen in patients with TAA and dissections. Prenatal treatment of such
mice with the angiotensin II type 1 (AT1) receptor antagonist losartan prevented elastic fiber fragmentation
in the aortic media of newborn mice. We currently focus on the effects of postnatal treatment in homozygous knockdown Fibulin-4 animals. The first results show that AT1 receptor blockade reduces aneurysm size,
and improves heart function.
Last year, thanks to a collaborative approach of
multiple departments within the Erasmus MC a
micro-CT scanner (QuantumFX) was installed in
the AMIE (Applied Molecular Imaging Erasmus MC)
facility. This new scanner allows one to obtain high
resolution fast scans non-invasively, which is ideal
for longitudinal studies, e.g., during treatment with
losartan. The first results on the 3D progression
state of the aneurysm (Figure) show that aneurysm
growth is stabilized by AT1 receptor blockade. In the
near future we intend to perform in vivo imaging of
the remodeling processes by using 3D fluorescencebased tomography (FMT) combined with micro-CT.
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In parallel, we started a RNA-profiling project for the identification of genetic factors involved in abdominal
aorta aneurysm (AAA) formation. By comparing tissue of AAA patients with a non-AAA-affected group, we
hope to obtain not only new insights in the remodeling processes, but also potential biomarkers.
In summary, my PhD project focuses on both pharmacological intervention (with RAS blockers) and
screening (via early biomarkers) of aneurysms. Through RNA-profiling we might even discover new treatment targets.
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Project 25
Endovascular management of aortic aneurysms
Aortic pathology like aneurysms, dissections and traumatic ruptures were traditionally treated by open surgery
repair. In the last decade, endovascular technology became available as a minimally invasive alternative. Like
with all other new and innovative treatment modalities, results, especially long-term, are unknown and it
remains unclear whether this minimal invasive treatment is beneficial for all patients or only for the ones
declared “unfit for surgery”. Furthermore, many uncertainties remain on the best indications for stentgraft
placement: is it only advisable for aneurysmal disease or should it be used for all aortic pathology known to
eventually lead to life-threatening dilatation of the aorta. If so, in what stage of the disease should it be used:
as treatment or as prevention? Can it be seen as definitive treatment or will it turn out to be just a “bridge to
surgery”? Within this project, many sides of this new treatment are being investigated.
Principal Investigator Co-Investigators
HJM Verhagen
JA Bekkers, B Muhs, EV Rouwet, F Schlosser, O Schouten
PhD candidates
Name
Subject
MV Bastos Goncalves
Aortic calcification and perioperative cardiovascular risk
SA Cornelissen
Advances in imaging after EVAR
JMW Donker
Modern outcomes in Vascular Surgery
FHW Jonker
Thoracic Aortic Catastrophies, towards an endovascular solution
J van Keulen
Endovascular management of Aortic Pathology
JH van Laanen
Long-term CAS
KM vd Luijtgaarden
Familial Aneurysms
KHJ Ultee
Clinical Outcome of Endovascular Treatment for Elective and Ruptured Abdominal Aortic
Aneurysms
MT Voûte
Diagnosis and treatment of cardiovascular complications in vascular surgery patients
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Project 26
Improvement in the prevention of sudden cardiac death
Therapy for survivors of sudden cardiac death has improved considerably. Prevention is now performed by
selecting high risk patients to receive a prophylactic device (implantable cardioverter defibrillators, or ICD`s).
This is not always easy, nor cost effective. Therefore, we are focusing more and more on co-morbidity and cost
efficacy of this therapeutic modality.
Quality of life is an important issue in this matter while technical improvements also play a very
important role to make this therapy acceptable. The role of anti-tachycardia pacing and resynchronization
therapy has influenced the role of the ICD alone (the shock box) within the therapeutic arsenal. In this regard,
developments such as the subcutaneous ICD are a potential improvement. Home monitoring for implants is
another promising tool but its exact place remains undefined. Several local as well as multicenter studies in
this area are being undertaken by our group to enhance our understanding of these issues.
LMJL Jordaens
Co-Investigators
MGM Hunink, SS Pedersen, JCJ Res, DAMJ Theuns
PhD candidates
Name
Subject
L Dabiri Abkenari
Actual Insights on Prophylactic ICD Therapy
SDA Valk
Approaches to ventricular tachycardia and sudden death
81
Project 27
Lung surgery and lung transplantation
Technological developments in lung/thoracic surgery in the direction of video-assisted surgery as well as
improvements in peri-operative care are actual issues, resulting in concentration in larger centres. Larger series
and better quality of care are the result and form a sound basis for further clinical research and cooperation at
international level. A multidisciplinary approach is the key to this goal. This also holds for lung transplantation
for which also preclinical studies on organ preservation are undertaken. This project aims at outcome research
with emphasis on clinical decision making.
AJJC Bogers
Co-Investigator
AP Kappetein
Postdoc
O Birim
PhD candidates
Name
Subject
NP van der Kaaij
Ischemia reperfusion injury as a risk factor for the development of chronic transplant
dysfunction after lung transplantation
APMW Maat
Surgical aspects of mesothelioma treatment
82
Project 28
Stem cell therapy of acute coronary syndromes
The Thoraxcenter has taken an interest in cardiovascular regenerative medicine since 2000. Initially, we
have studied the effect of intramyocardial injection of skeletal myoblasts in patients with congestive heart
failure. In 2007, we initiated a new approach of cardiac stem cell therapy by use of adipose-tissue derived
mesenchymal-like stem cells (ADRC) in the treatment of cardiovascular patients, including acute myocardial
infarction (APOLLO) and ischemic congestive heart failure (PRECISE). The APOLLO, first-in-man application of
these ADRCs, suggested a beneficial effect on myocardial salvage and local perfusion following a myocardial
infarction, resulting in preservation of global left ventricular function and reduction of ventricular arrhythmias.
Hence, in the current ADVANCE study, the effect of these ADRCs in the treatment of AMI is further evaluated in
a multicentered, prospective study in 375 AMI patients. Allogeneic stem cell therapy may offer the opportunity
to optimize cellular graft quality, and to represent a true off-the-shelf cell product. In the AMICI-1 study, an
allogeneic mesenchymal precursor stem cell therapy is tested in 225 patients with a myocardial infarction.
In porcine and ovine large animal models, the working mechanism, optimal conditions and efficacy of
various stem cell therapy approaches are currently being evaluated (collaboration with the Exp.Card.dept. of
the UMCU (G. Pasterkamp, I.Hoefer)).
Here, we study the effect of CellBeads, aliginate beads with clusters of allogeneic mesenchymal stem cells,
transduced to elute cardioprotective proteins i.e. recombinant glucagon-like-peptide 1, in the treatment of
congestive heart failure and acute myocardial infarction.
In addition to regenerative cardiovascular therapy, the molecular cardiology laboratory has an interest to
evaluate various molecular biomarkers in the diagnosis, prognostication and drug responsiveness in patients
with ischemic heart disease. In the BioTxs biobank, genetic material is collected from blood samples of CAD
patients to develop a proprietary blood test for ischemic disease based on specific transcripts or the autoantibody profile.
HJ Duckers
Co-Investigators
I Hoefer, A Lewis, G Pasterkamp, C Wallrap PhD candidates
Name
Subject
HJ Houtgraaf
Cell therapy in myocardial infarction and heart failure
R de Jong
Allogeneic Stem cell Transplantation Use of GLP-1 Producing Cellbeads for the treatment of
cardiovascular disease
83
Project 29
Percutaneous Interventions in Structural Heart Disease
Catheter-based treatment of structural heart disease is a recent but rapidly evolving treatment modality. At
present it is primarily reserved for patients with aortic stenosis who are considered poor candidate for surgical
valve replacement. As a result of ongoing research and innovations in catheter technology, bioprosthetic
materials (scaffolding frame and tissue), imaging (3-4D, co-registration) in addition to operator experience,
it is expected that catheter-based treatment will also be available for other forms of structural heart disease
such as mitral – and aortic regurgitation, left ventricular systolic dysfunction in addition to the application of
these techniques in patients who are candidate for surgical treatment.
Research in this domain will encompass 1] clinical cohort research examining the safety and efficacy,
the evaluation of responder and non-responder by the definition of determinants of (clinical and technical)
outcome by means of single- and multicenter collaborative efforts, 2] pathophysiologic assessment of the
effects of treatment on the morphology, function and haemodynamics of various cardiac components
(myocardium, valves, ascending aorta) in collaboration with the department of radiology and experimental
cardiology, 3] randomised clinical comparison between catheter-based and surgical treatment of structural
heart disease, 4] advanced imaging allowing 3 and eventually 4 D co-registration of the anatomy during
treatment (collaboration with experimental cardiology, radiology and industry)
PPT de Jaegere, PW Serruys
Co-Investigators
RT van Domburg, RJ van Geuns, MJ Lenzen, CS Schultz, M Witsenburg
PhD candidates
Name
Subject
RMA van der Boon
Transcatheter Aortic valve implantation insights into clinical complications
NMDA van Mieghem
Evolving transcatheter treatment strategies in mitral and aortic valve disease
MJAG de Ronde-Tillmans
Influence of TAVI on quality of life in elderly patients with Aortic Stenosis
84
Project 30
Translational electrophysiology:
QUASAR Project: Amor Project: Danara Project: RiverLeft: Quest for the Arrhythmogenic Substrate of Atrial FibRillation
RotterdAm RhythM MonitORing
Dysrhythmias in pAtients with CongeNitAl HeaRt DiseAse
Treatment of Paroxysmal Atrial Fibrillation in Patients with the Sick Sinus Syndrome; the Rijnmond Right versus Left Study.
The research projects of the unit translational electrophysiology are aimed at developing innovative
diagnostic tools and therapies by implementing experimental electrophysiology in daily clinical practice.
Atrial fibrillation (AF) is associated with significant morbidity and mortality. The prevalence of AF will
continue to rise and AF will persist to pose a major burden on public health costs. Anti-arrhythmic drugs are
often not effective in eliminating AF episodes and ablative therapy is also not so successful as first assumed.
The expected epidemic of AF necessitates research in order to develop preventive strategies, to improve
existing treatment modalities and design novel therapies. After the discovery that paroxysms of AF can be
triggered by pulmonary vein foci, isolation of the pulmonary veins was introduced as a potential curative
treatment modality. It is in general assumed that in patients with persistent AF, AF has progressed from a
trigger-driven to a substrate mediated arrhythmia. In these patients, persistence of AF no longer depends
on the presence of a trigger (‘true fibrillation’) but is maintained by an arrhythmogenic substrate. Although
animal studies have provided extensive insights into the various mechanisms that can explain perpetuation
of AF, it is unknown which specific electropathological changes are relevant for the development of a
substrate of persistent AF in humans. Also, it is unknown whether different cardiac diseases result in different
electro-pathological alterations. Particularly in patients with congenital heart disease, there are no mapping
data available. Clinical mapping data of AF are scarce and the available studies are often limited to parts of
the atria or a small number of beats. Theoretically, multi-site high density mapping can be used to localize
sources generating AF in patients with trigger-driven AF and to identify areas perpetuating AF in patients with
substrate mediated-AF. Based on the premise that AF can be eliminated by ablation of either the trigger or the
substrate perpetuating AF it is expected that multi-site high density mapping is a suitable tool to diagnose AF
thereby allowing individualization of AF treatment. The mechanism of early post-operative dysrhythmias is
studied by correlating continuous rhythm registrations with hemodynamic alterations.
85
Translational electrophysiology
NMS de Groot
Co-Investigators
MA Allessie, AJJC Bogers, C Kik, F Zijlstra
PhD candidates
Name
Subject
P Bhagirath
Cardiac imaging and electrophysiology
R Bhagwandien
A comparison of radiofrequency and cryotherapy for ablation
AWM van der Graaf
Cardiac imaging and electrophysiology
P Knops
The arrhythmogenic substrate of atrial fibrillation
TTTK Ramdjan
Mechanisms underlying persistence of atrial fibrillation
A Yaksh
The electropathological substrate of atrial fibrillation in patients with coronary artery
disease
86
“DysrhythmiAs in patieNts with congenitAl heaRt diseAse”
DANARA project: an international multicenter study
“Treatment of Paroxysmal Atrial Fibrillation in Patients with Sick Sinus Syndrome: Right
Atrial Stimulation Compared with Left Atrial Stimulation”
Riverleft: a multicenter, randomized controlled trial - Tanwier Ramdjan
Cardiac dysrhythmias are common late complications in patients with congenital heart defects (CHD). The
incidence of dysrhythmias in CHD patients is higher compared to the general population. Corrective or palliative surgery may play a role in the development of dysrhythmias by e.g. facilitating reentry along suture
lines, patches or areas of scar tissue.
87
However, dysrhythmias are also documented in patients with unrepaired CHDs. In these patients, chronic
pressure and/or volume overload may give rise to cardiac conduction abnormalities and hence to dysrhythmias.
In 2012, the “DysrhythmiAs in patieNts with congenitAl heaRt diseAse” (DANARA) project, an international multicenter study was initiated by Dr. Natasja de Groot.
At present, we have included 750 CHD patients with either brady- and/or tachyarrhythmias. The aim of this
project is to examine time course of development of both early and late post-operative bradycardia, atrial or
ventricular tachyarrhythmia in CHD patients in relation to specific CHDs, surgical procedures and arrhythmia characteristics. Data derived from this project are used to gain further insight into the mechanisms
underlying cardiac dysrhythmias in patients with congenital heart defects.
Sinus node dysfunction (SND) accounts for approximately 50 % of the pacemaker implantations.
Symptomatic paroxysmal atrial fibrillation (AF) occurs in 30% of these patients.
Clinical studies have provided evidence that atrial pacing may prevent episodes of AF.
It is common practice to implant atrial leads in the right atrial appendage (RAA); however, pacing in this
position is insufficiently effective to prevent AF episodes.
The right versus left (Riverleft) study is therefore to determine the effect of distal coronary sinus pacing
compared to RAA pacing for the prevention of recurrent AF episodes. Total number of AF recurrences and
time between recurrences will be assessed and compared between both groups. Patients of 18 years or older
with SND and at least one PAF episode of ≥ 30 seconds within six months before enrollment, will be eligible
to participate in the study. A conventional dual chamber with home-monitoring functionalities will be implanted in all patients.
88
Project 31
Surgical aspects of acute and chronic cardiovascular disease and heart failure
Technological developments in surgery (and interventional cardiology as well) and peri-operative/periprocedural care continue to evolve at a rapid pace. In particular, the field evidence with regard to the treatment
of coronary artery disease and cardiac valvular disease is rapidly expanding. The search for hybrid approaches
applying minimal invasive techniques continues. This is also relevant for the further development of robotic
techniques. It was shown that a multidisciplinary approach delivers the best results, and collaboration
between engineers, cardiologists, cardiothoracic and vascular surgeons and radiologists is the preferred and
chosen route. This project aims at outcome research with emphasis on clinical decision making.
AJJC Bogers
Co-Investigators
H Boersma, AP Kappetein, JJM Takkenberg
PhD candidates
Name
Subject
LE de Groot-de Laat
Three-dimensional echocardiography in mitral regurgitation
WJ van Leeuwen
Clinical results of mitral valve surgery
89
Project 32
Determinants of outcome of pediatric (congenital) heart disease
Treatment of congenital heart disease in early childhood has resulted in excellent survival in the pediatric age
range. However, residual cardiac loading abnormalities and the effects of pre-treatment hypoxaemia may
impair long term survival and quality of life. The project aims to identify early (bio)markers of suboptimal
outcome following treatment in childhood and to develop new treatment modalities to improve outcome.
Novel imaging methods and animal experiments are used for these purposes.
WA Helbing
Co-Investigators
M Dalinghaus, DJGM Duncker, LP Koopman, IKM Reiss, JW Roos-Hesselink,
JJM Takkenberg, M Witsenburg
PhD candidates
Name
Subject
SL den Boer
Heart failure in children with cardiomyopathy. Which markers can be used to predict
outcome?
SMM Bossers
Long-term outcome of the single ventricular circulation: multicenter study to assess risk
factors for heart failure and reduced health related quality of life
EAB Buijs
In vivo and in vitro assessment of pediatric microvascular functioning with particular
emphasis on catecholamines and catecholamine receptors
N Duppen
Exercise training in congenital heart disease: is it effective and safe and does it improve
quality of life?
90
Project 33
Surgery for congenital heart disease
Surgical management of congenital heart disease has improved significantly in the last decades and has
resulted in improved survival into adulthood. Thus the number of adult patients is growing. While the number
of patients to be operated at young age is more or less constant, the number of patients needing an operation
at adult age is increasing, both the number of primary operations as well as the number of reoperations due
to residual cardiac abnormalities. In particular, an abnormal load is commonly imposed on the right ventricle
or on single ventricular hearts. Residual abnormalities may cause heart failure, rhythm disturbances and may
affect quality of life. Evidence-based treatment is often lacking. Guidelines for timing of catheter intervention
and surgical therapy also may lack sufficient evidence. This project aims at outcome research with emphasis
on assessment of cardiac function in the right ventricle and in structurally abnormal hearts with conventional
imaging techniques. An important part of this theme concerns these imaging techniques on one hand and
improvement of clinical decision-making and therapy on the other.
AJJC Bogers
Co-Investigators
WA Helbing, AP Kappetein, L van Osch-Gevers, JW Roos-Hesselink, JJM Takkenberg
PhD candidates
Name
Subject
JAAE Cuypers
Very long term follow-up after surgical correction of congenital heart disease at young age
A Mookhoek
Changing Roots: remodelling after the Ross procedure
A van Saet
Pharmacokinetics and pharmacodynamics of drugs in neonates and children during
cardiopulmonary bypass
PC vd Woestijne
Pulmonary atresia with ventricular septal defect and systemic-pulmonary collateral arteries
GA Zeilmaker
Pharmacokinetics and pharmacodynamics of drugs in neonates and children during
cardiopulmonary bypass
91
Surgery for congenital heart disease
Donating a heart valve to yourself - Aart Mookhoek
“At the Department of Cardio-thoracic Surgery, we are interested in studying all aspects of aortic valve
replacement: from valve biology to clinical decision-making.”
The focus of my PhD project is the Ross procedure. In this procedure, surgeons replace the aortic root
by the patient’s own pulmonary root. The right ventricular outflow tract is then reconstructed with a
homograft or heterograft. The rationale behind this procedure is to have a living, non-immunogenic valve in
the systemic circulation.
In The Netherlands, the Ross procedure is nowadays performed almost exclusively in young children.
Worldwide, only a few centres perform this procedure in adults. The foremost reason why enthusiasm for
the procedure is limited, is that progressive dilatation of the neo-aortic (autograft) root may necessitate
reoperation.
So, why does the autograft root dilate? Differences in wall composition between native aortic and
pulmonary roots in combination with higher pressures in the systemic circulation likely cause dilatation. A more interesting question is: to what extent does the autograft adapt to the demands of the systemic circulation and how may we facilitate this adaptation process?
To look for answers to this question, I am fortunate to collaborate with several national and
international institutes. Together, we study the histology and biomechanics of explanted autograft roots,
observe how neonates and infants fare after the Ross procedure and determine which variables predict a
successful outcome once a reoperation on the autograft root becomes necessary.
I believe these and other projects will continue to offer interesting new challenges in the year to come.
We hope the lessons learned from studying the Ross procedure will benefit our patients directly and may
offer novel insights into the process of aneurysm formation and aortic dissection.
92
93
Project 34
Perioperative care
Cardiovascular disease is the major cause of postoperative morbidity and mortality. In Europe, 40.000.000
surgical procedures are performed every year, with a cardiovascular mortality rate of 0.3% (133.000 patients).
To improve postoperative outcome, preoperative identification of patients at risk is performed using
clinical risk scores, biomarkers for coronary artery disease and heart failure, and cardiac imaging. The
preoperative risk assessment is linked to the intraoperative identification of acute coronary syndromes using
electrocardiography and cardiac imaging as well as newly identified biomarkers. The follow-up of these patients
is performed regularly, for early identification of cardiac events. The identification of a genetic predisposition
in relation with biomarkers and subsequent treatment is the research line of this group.
RJ Stolker, H Verhagen
Co-Investigator
S Hoeks
PhD candidates
Name
Subject
LH Derks
Perioperative care in noncardiac surgery: aspirin initiation prior to surgery
W Galal
Correlation of pre- and perioperative ischemia in vascular surgery
F Grüne
Changes of effective downstream pressure in cerebral perfusion under influence of
anesthetics and vasoactive drugs
R Kuyper
Use of handheld echo device in perioperative care
DY Lin
Decrease XVI: aspirin in preventing cardiovascular events in patients undergoing
noncardiac surgery
MAH van Velzen
The making of the 'MPA-16'
94
Project 35
Clinical decision making in cardiac surgery
This project concerns risk modelling, decision making, innovative statistical analysis and health technology
assessment of appropriate diagnostic and therapeutic measures in the area of cardio-thoracic interventions.
One of the challenges for contemporary medicine is to apply evidence-based medicine and to rationally
implement the available therapies in clinical practice, in the appropriate patients at the appropriate time.
Current research includes the application of longitudinal statistical models on serial data such as cardiac
biomarkers and echocardiographic measurements over time for the purpose of outcome prediction, the
optimization of individualized prognosis prediction through the development of novel risk models, shared
decision making studies in prosthetic heart valve selection and NSCLC treatment selection, and costeffectiveness studies of novel cardio-thoracic interventions. The results are applied in outcome research and
should support clinical decision making.
AJJC Bogers, JJM Takkenberg
Co-Investigator
AP Kappetein
PhD candidates
Name
Subject
ER Andrinopoulou
Statistical tools for the investigation of the prognostic ability of biomarkers
E Charitos
A framework for the evaluation and reporting of outcomes after complex heart valve
operations
NM Korteland
Optimizing clinical decision-making in prosthetic aortic valve selection
HJ Heuvelman
Characteristics, treatment options and prognosis of patients with aortic stenosis
S Mokhles
Prognostication and decision making in non-small cell lung carcinoma
RLJ Osnabrugge
Evaluation and clinical integration of new techniques in cardiac surgery
95
Project 36
Clinical epidemiology of cardiovascular diseases
In the past decades, significant improvement has been achieved in the management and outcome of
patients with cardiovascular disease (CVD). Despite these developments, CVD still is a major cause of the
loss of healthy years in The Netherlands: the annual number of fatal events is as high as 40,000. The burden
of CVD is expected to increase in the decades ahead, and it is crucial to develop and improve CVD risk
prediction instruments, and implement appropriate preventive and therapeutic measures. Traditionally,
the assessment of CVD risk is based on global risk models. However, these models fall short, as they do not
utilize contemporary knowledge on the pathophysiology of CVD. Project 36 is designed to improve CVD risk
assessment and risk reduction. Several concepts are currently studied: (multiple) CVD biomarkers, repeated
biomarker assessment, cardiac imaging, dynamic risk modelling and simulation risk modelling.
H Boersma
Co-Investigators
KM Akkerhuis, RT van Domburg, JL Hillege, RJ van Geuns, I Kardys, MJ Lenzen,
MD Levin, SS Pedersen, V Umans
PhD candidates
Name
Subject
SS Anroedh
ECGs and Biomarker measurements in coronary disease and heart failure
LC Battes
Micro-simulation modelling for clinical decision-making in individual patients with
coronary artery disease
SPM de Boer
Determinants of prognosis in patients undergoing percutaneous coronary intervention
N van Boven
Serial Biomarker measurements and new echocardiographic techniques in chronic Heart
Failure patients result in Tailored prediction of prognosis (Bio-SHiFT)
JM Cheng
Determinants of prognosis in patients with acute heart failure
NLM Damen
Psychological factors & biomarkers in Cardiac patients treated with PCI: overlapping or
independent Risk markers for morbidity & mortality?
C Liesting
Cardiotoxicity of treatment in patients with HER2Neu positive breast cancer
RM Oemrawsingh
Prognostic value of biomarkers in patients with chronic CAD
M Sunamura
Opticare: optimal cardiac rehabilitation following acute coronary syndrome
LC van Vark
Epidemiological validation and clinical implementation of candidate biomarkers in patients
with acute heart failure
96
Project 37
Adult congenital heart disease
In the Netherlands, 8 out of 1000 children are born with a congenital heart defect. Due to improved
diagnostics, the introduction of the heart lung machine and open heart surgery, more than 85% of these
patients reach adulthood and nowadays there are 30.000 adults living in the Netherlands. Many of them have
late complications, such as valvular dysfunction, arrhythmias or heart failure. In addition often surgical or
catheter reintervention is necessary. Research in project 37 focuses on long-term outcome in these patients,
both after surgical correction, interventional treatment or natural history. Special emphasis on psychological
outcome, pregnancy and sports participation is important in this specific group of young adults. Also genetic
research, imaging of the complex cardiac anatomy and biomarker studies are being conducted.
JW Roos-Hesselink
Co-Investigators
H Boersma, AJJC Bogers, AE van den Bosch, RT van Domburg, WA Helbing,
MGM Hunink, JJM Takkenberg, EMWJ Utens, M Witsenburg
PhD candidates
Name
Subject
JA Eindhoven
Prognostic value of biomarkers in adult congenital heart disease patients
IM van Hagen
Pregnancy and Cardiac Disease
MJG Leening
Epidemiologic aspects of cardiovascular disease. A population-based approach
ME Menting
Echocardiography in congenital heart disease
JO Younge
Randomized controlled trial of mindfulness training as complementary therapy in adults
with structural heart disease
97
Doctoral degrees
21 out of the 24 doctorates had included a detailed
portfolio. Missing portfolios were exclusively associated with foreign PhD candidates. The median
number of ECTS points scored was 33. The time
to PhD degree varied between three and six years
with a median time of 4 years and nine months.
COEUR currently lists 199 PhD candidates. In 2013,
the drop-out ratio was 1 %, as 2 candidates discontinued their PhD trajectory.
In the year 2013, 24 COEUR PhD candidates successfully defended their PhD thesis and obtained
a doctoral degree. Details of their achievements
are given on the next pages. Apart from scientific
accomplishments, PhD candidates are required
to document their educational activities (courses,
meetings and teaching) in their portfolio, which is
integral part of their thesis. Thirty ECTS (European
Credit Transfer Score) points are required. In 2013,
Doctoral degrees 2003 - 2013
99
January 25, 2013
Azadeh Firouzian
Automated Analysis of Intracranial Aneurysm Morphology and Dynamics
from CTA Data
Promotor: professor Wiro J Niessen (Radiology/Biomedical Imaging)
Copromotor: dr R Manniesing (Biomedical Imaging)
February 20, 2013
Martijn van Geldorp
Severe Aortic Stenosis, diagnosis, treatment and prognosis
Promotores: professor Hanneke JJM Takkenberg (Cardiothoracic Surgery) and
professor Arie Pieter Kappetein (Cardiothoracic Surgery)
Maart 14, 2013
Alexandre Lima
Noninvasive Monitoring Of Peripheral Perfusion In Critically Ill Patients
Promotor: professor Jan Bakker (Intensive Care)
Copromotor: dr Jasper van Bommel (Intensive Care)
Maart 15, 2013
Simone Talens
Novel Fibrin Clot Components
Promotor: professor Frank WG Leebeek (Hematology)
Copromotor: dr Dick C Rijken (Hematology)
100
Denise van der Linde
CUM LAUDE
April 19, 2013 - CUM LAUDE
Denise van der Linde
Congenital Aortic Stenosis and Aneurysms
Promotores: professor Jolien W Roos-Hesselink (Cardiology) and
professor Hanneke JJM Takkenberg (Cardiothoracic Surgery)
June 4, 2013
Lisan Neefjes
CT Coronary angiography to Detect Coronary Artery Disease: Low Dose
Radiation in High Risk Individuals
Promotores: professor Gabriel P Krestin (Radiology) and
professor Pim J de Feyter (Cardiology)
June 11, 2013
Rutger - Jan Nuis
Transcatheter Aortic Valve Implantation: Current Results, Insights and Future
Challenges
Promotores: professor Peter PT de Jaegere (Cardiology) and Professor
Felix Zijlstra (Cardiology)
Copromotor: dr Ron T van Domburg (Cardiology)
June 12, 2013
Pieter M Jansen
The Role of Aldosterone and Aldosterone Blockade in Hypertension
Promotor: professor AH Jan Danser (Internal Medicine)
Copromotor: dr Anton H van den Meiracker (Internal Medicine)
102
June 14, 2013
Hortense A Kirisli
CTA Quantification and Multi-modal Visualization for Assessing Coronary
Artery Disease
Promotores: professor Wiro J Niessen (Radiology/Biomedical Imaging) and
professor Hans JHC Reiber (Radiology LUMC, Leiden)
Copromotor: dr Theo van Walsum (Radiology/Biomedical Imaging)
June 18, 2013
David Maresca
Ultraharmonic IVUS Imaging of Microvascularization
Promotores: professor Anton FW van der Steen (Biomedical Engineering) and
professor Nico de Jong (Biomedical Engineering))
Copromotor: dr Gijs van Soest (Biomedical Engineering)
June 25, 2013
Saskia E Luijnenburg
Outcome Late After Repair of Tetralogy of Fallot
Promotores: professor Wim A Helbing (Pediatrics) and
professor Barbara JM Mulder (Cardiology AMC, Amsterdam)
Copromotor: dr Hubert W Vliegen (Cardiology LUMC, Leiden)
June 28, 2013
Alexia Rossi
Quantification in Non-invasive Cardiac Imaging: CT and MR
Promotores: professor Gabriel P Krestin (Radiology) and
professor Jolien W Roos-Hesselink (Cardiology)
Copromotor: dr Robert Jan van Geuns (Cardiology)
103
September 13, 2013
P Titia E Ruys
Adult Congenital Heart Disease with Focus on Pregnancy
Promotor: professor Jolien W Roos-Hesselink (Cardiology)
September 20, 2013
Petra Opićć
Impact of Congenital Heart Disease at Adulthood
Promotor: professor Jolien W Roos-Hesselink (Cardiology)
Copromotor: dr Liesbeth EMWJ Utens (Paediatrics)
September 24, 2013
Tabita M Valentijn
Novel Insights in Perioperative Care
Promotores: professor Robert Jan Stolker (Anaesthesiology) and
professor Hence Verhagen (Vascular Surgery)
Copromotor: dr Sanne E Hoeks (Anaesthesiology)
October 2, 2013
Erik Jan Bakker
Cardiac Complications after Non-cardiac Surgery; Perioperative Risk
Prediction and Reduction Strategies
Promotores: professor Robert Jan Stolker (Anaesthesiology) and
professor Hence JM Verhagen (Vascular Surgery)
104
October 11, 2013
Stuart J Head
An Appraisal of Developments in Surgical and Catheter–based Cardiovascular
Therapy
Promotores: professor Arie Pieter Kappetein (Cardiothoracic Surgery) and
professor Ad JJC Bogers (Cardiothoracic Surgery)
October 15, 2013
Maarten de Mulder
Glucose Regulation in Acute Coronary Syndromes
Promotor: professor Eric Boersma (Cardiology)
Copromotor: dr Victor AWM Umans (Cardiology MCA, Alkmaar)
October 23, 2013
Ali Ç Akyildiz
Biomechanical Modeling of Atherosclerotic Plaques for Risk Assessment
Promotor: professor Anton FW van der Steen (Biomedical Engineering)
Copromotor: dr ir Frank JH Gijsen (Cardiology)
November 4, 2013
Rahil Shahzad
Quantification of Imaging Biomarkers For Cardiovascular Disease in CT(A)
Promotor: professor Wiro J Niessen(Biomedical Imaging)
Copromotor: professor dr ir Lucas J van Vliet (Imaging and Applied Sciences
Delft University of Technology)
105
November 12, 2013
Zhichao Zhou
The Dual Face of Endothelial Control of Vascular Tone
Promotor: professor Dirk Jan GM Duncker (Cardiology)
Copromotor: dr Daphne Merkus (Cardiology)
December 3, 2013
Hilde RH De Geus
Biomarkers for AKI
Promotores: professor Jan Bakker (Intensive Care)
and professor AB Johan Groeneveld (Intensive Care)
Copromotor: dr Michiel GH Betjes (Internal Medicine)
December 18, 2013 - CUM LAUDE
M Mostafa Mokhles
Innovative Modeling of Outcome in Cardiac Surgery
Promotores: professor Ad JJC Bogers (Cardiothoracic Surgery) and
professor Hanneke JJM Takkenberg (Cardiothoracic Surgery)
December 18, 2013
Krista Jansen
Intravascular Photoacoustics
Promotor: professor Anton FW van der Steen (Biomedical Engineering)
Copromotor: dr Gijs van Soest (Cardiology)
106
107
Citation Classics (2013)
1. Serruys PW, de Jaegere P, et al. A comparison of balloon-expandable-stent implantation with balloon
angioplasty in patients with coronary-artery disease. New Engl J Med. 1994;331:489-495 [cited
3117x].
2. Altman R, et al. [incl. Koudstaal PJ, Serruys PW]. Collaborative overview of randomized trials
of antiplatelet therapy.1. Prevention of death, myocardial-infarction, and stroke by prolonged
antiplatelet therapy in various categories of patients. BMJ. 1994; 308:81-100 [cited 2336x].
3. Morice MC, Serruys PW, et al. A randomized comparison of a sirolimus-eluting stent with a standard
stent for coronary revascularization. N Engl J Med. 2002;346(23):1773-80 [cited 2097x]
4. Lechat P, et al. [incl. Jordaens L].The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised
trial. Lancet. 1999;353:9-13 [cited 2021x].
5. Appleby P, et al. [incl. Simoons ML]. Indications for fibrinolytic therapy in suspected acute
myocardial-infarction - Collaborative overview of early mortality and major morbidity results from
all randomized trials of more than 1000 patients. Lancet 1994;343:311-322 [cited 1546x]
6. van Swieten JC, Koudstaal PJ, et al. Interobserver agreement for the assessment of handicap in
stroke patients. Stroke. 1988;19:604-607 [cited 1538x].
7. Topol E, et al. [incl Simoons ML] An international randomized trial comparing 4 thrombolytic
strategies for acute myocardial infarction. New Engl J Med. 1993;329:673-682 [cited 1409x]
8. Bots ML, et al. [incl Koudstaal PJ]. Common carotid intima-media thickness and risk of stroke and
myocardial infarction – the Rotterdam Study. Circulation. 1997;96:1432-1437 [cited 1198x]
9. Topol E, et al [incl. Deckers JW, Simoons ML]. Inhibition of platelet glycoprotein llb/llla with
eptifibatide in patients with acute coronary syndromes. New Engl J Med. 1998;339:436-443 [cited
1127x].
10. Ross AM, Simoons ML, et al. The effects of tissue-plasminogen activator, streptokinase, or both on
coronary-artery patency, ventricular-function, and survival after acute myocardial-infarction. New
Engl J Med. 1993;329:1615-1622 [cited 1008x]
108
Publications
Pub Med publications (2013)
J, Hubay M, Lendvai Z, Merkely B, Szili-Torok
T. Radiofrequency Ablation at Low Irrigation
1.
Abraham P, Abkenari LD, Peters ECH, Szili-Torok
Flow Rates Using a Novel 12-Hole Gold Open-
T. Feasibility of Remote Magnetic Navigation for
Irrigation Catheter. Pacing Clin Electrophysiol.
Epicardial Ablation. Netherlands Heart Journal.
2013;36(11):1373-81.
2013;21(9):391-5.
2.
7.
Cleophas TJ. Effect of Collaterals on Deaths and
Carcao MD, Cox Gill J, Key NS, Kouides PA,
Re-Infarctions in Patients with Coronary Artery
Kurnik K, Lail AE, Leebeek FWG, Makris M,
Disease: A Meta-Analysis. Netherlands Heart
Mannucci PM, Winikoff R, Berntorp E. Prophylaxis
in Severe Forms of Von Willebrand’s Disease:
3.
Journal. 2013;21(3):146-51.
8.
A, Van Der Lugt A, Vernooij MW. Cerebral
Prophylaxis Network (Vwd Pn). Haemophilia.
Microbleeds and the Risk of Mortality in
2013;19(1):76-81.
the General Population. Eur J Epidemiol.
Adams HHH, Cavalieri M, Verhaaren BFJ, Bos D,
2013;28(10):815-21.
9.
van Dijke CF, Niessen WJ, Veenland JF. Regional
Robin Spaces on Magnetic Resonance Imaging.
Heterogeneity Changes in Dce-Mri as Response
Stroke. 2013;44(6):1732-5.
to Isolated Limb Perfusion in Experimental Soft-
Akca F, Schwagten B, Theuns DAJ, Takens M,
Tissue Sarcomas. Contrast Media and Molecular
of Single-Catheter Ablation Using Remote
6.
Alic L, van Vliet M, Wielopolski PA, ten Hagen TLM,
R, Ikram MA. Rating Method for Dilated Virchow-
Musters P, Szili-Torok T. Safety and Feasibility
5.
Akoudad S, Ikram MA, Koudstaal PJ, Hofman
Results from the Von Willebrand Disease
Van Der Lugt A, Enzinger C, Vernooij MW, Schmidt
4.
Akin S, Yetgin T, Brugts JJ, Dirkali A, Zijlstra F,
Abshire TC, Federici AB, Alvárez MT, Bowen J,
Imaging. 2013;8(4):340-9.
10.
Amrane H, Porta F, Van Boven AJ, Hofma SH, Head
Magnetic Navigation for Treatment of Slow-Fast
SJ, Kappetein P. Tools and Techniques - Clinical: The
Atrioventricular Nodal Reentrant Tachycardia
Transaortic Approach through a Mini-Sternotomy
Compared to Conventional Ablation Strategies.
Using the Self-Expandable Corevalve Revalving
Acta Cardiol. 2013;68(6):559-67.
System. EuroIntervention. 2013;9(5):648-9.
Akca F, Theuns DAMJ, Abkenari LD, De Groot
11.
Arias A, Petersen J, Van Engelen A, Tang H,
NMS, Jordaens L, Szili-Torok T. Outcomes
Selwaness M, Witteman JCM, Van Der Lugt A,
of Repeat Catheter Ablation Using Magnetic
Niessen W, De Bruijne M. Carotid Artery Wall
Navigation or Conventional Ablation. Europace.
Segmentation by Coupled Surface Graph Cuts.
2013;15(10):1426-31.
LNCS. 2013; 7766: 38-47.
Akca F, Zima E, Vegh EM, Szeplaki G, Skopal
12.
109
Assink-de Jong E, Groeneveld ABJ, Pettersson
AM, Koek A, Vandenbroucke-Grauls CMJE,
18. Bakker EJ, Valentijn TM, Van de Luijtgaarden KM,
Beishuizen A, Simoons-Smit AM. Clinical
Hoeks SE, Voute MT, Goncalves FB, Verhagen HJ,
Correlates of Herpes Simplex Virus Type 1 Loads
Stolker RJ. Type 2 Diabetes Mellitus, Independent
in the Lower Respiratory Tract of Critically Ill
of Insulin Use, Is Associated with an Increased Risk
Patients. J Clin Virol. 2013;58(1):79-83.
of Cardiac Complications after Vascular Surgery.
13. Auger D, Hoke U, Bax JJ, Boersma E, Delgado V.
Anaesth Intensive Care. 2013;41(5):584-90.
Effect of Atrioventricular and Ventriculoventricular
19. Bakker J. Memorable Patients: I’ll Be Dead on
Delay Optimization on Clinical and
Friday. Intensive Care Med. 2013;39(5):962.
Echocardiographic Outcomes of Patients Treated
20. Bakker J, Nijsten MWN, Jansen TC. Clinical Use of
with Cardiac Resynchronization Therapy: A Meta-
Lactate Monitoring in Critically Ill Patients. Annals
Analysis. Am Heart J. 2013;166(1):20-9.
of Intensive Care. 2013;3(1):1-8.
14. Azadani AN, Chitsaz S, Mannion A, Mookhoek A,
21. Bakker RC, Akin S, Rizopoulos D, Kik C,
Wisneski A, Guccione JM, Hope MD, Ge L, Tseng
Takkenberg JJM, Bogers AJJC. Results of Clinical
EE. Biomechanical Properties of Human Ascending
Application of the Modified Maze Procedure as
Thoracic Aortic Aneurysms. Ann Thorac Surg.
Concomitant Surgery. Interactive Cardiovascular
2013;96(1):50-8.
and Thoracic Surgery. 2013;16(2):151-6.
15. Baka N, Metz CT, Schultz C, Neefjes L, van
22. Balázs T, Laczkó R, Bognár E, Akman S, Nagy P,
Geuns RJ, Lelieveldt BPF, Niessen WJ, Van
Zima E, Dobránszky J, Szili-Török T. Ablation Time
Walsum T, De Bruijne M. Statistical Coronary
Efficiency and Lesion Volume - in Vitro Comparison
Motion Models for 2d+T/3d Registration of X-Ray
of 4 Mm, Non Irrigated, Gold- and Platinum-Iridium-
Coronary Angiography and Cta. Med Image Anal.
Tip Radiofrequency Ablation Catheters. J Interv
2013;17(6):698-709.
16. Bakal JA, Ezekowitz JA, Westerhout CM, Boersma
Card Electrophysiol. 2013;36(1):13-8.
23. Banerjee J, Moelker A, Niessen WJ, Van Walsum
E, Armstrong PW. Association of Global Weather
T. 3d Lbp-Based Rotationally Invariant Region
Changes with Acute Coronary Syndromes: Gaining
Description. LNCS 2013;7728:26-37.
Insights from Clinical Trials Data. Int J Biometeorol.
24. Batenburg WW, Van Den Heuvel M, Van Esch
JHM, Van Veghel R, Garrelds IM, Leijten F,
2013;57(3):401-8.
17. Bakker EJ, Valentijn TM, Hoeks SE, Van De
Danser AHJ. The (Pro)Renin Receptor Blocker
Luijtgaarden KM, Leebeek FW, Verhagen HJM,
Handle Region Peptide Upregulates Endothelium-
Stolker RJ. Abo Blood Type Does Not Influence the
Derived Contractile Factors in Aliskiren-Treated
Risk of Cardiovascular Complications and Mortality
Diabetic Transgenic (Mren2)27 Rats. J Hypertens.
after Vascular Surgery. Eur J Vasc Endovasc Surg.
2013;31(2):292-302.
2013;45(3):256-60.
25. Battes L, Barendse R, Steyerberg EW, Simoons
110
ML, Deckers JW, Nieboer D, Bertrand M, Ferrari
the Bambui (Brazil) Cohort Study of Aging. Int J
R, Remme WJ, Fox K, Takkenberg JJM, Boersma
E, Kardys I. Development and Validation of a
Cardiol. 2013;166(2):523-6.
31. Beleigoli AM, Ribeiro AL, Diniz Mde F, Lima-Costa
Cardiovascular Risk Assessment Model in Patients
MF, Boersma E. Comparing the Value of Bnp in
with Established Coronary Artery Disease. Am J
Predicting Mortality among Community-Dwelling
Cardiol. 2013;112(1):27-33.
Elderly with and without Overweight/Obesity:
26. Battes L, Kardys I, Barendse R, Steyerberg EW,
The Bambui (Brazil) Cohort Study of Aging. Int J
Amiri M, Eijkemans MJC, Deckers JW, Postmus
D, Takkenberg JJM, Redekop K, Boersma E.
Cardiol. 2013;168(4):4364-6.
32. Berghauser Pont LME, Dippel DWJ, Verweij BH,
Microsimulation for Clinical Decision-Making in
Dirven CMF, Dammers R. Ambivalence among
Individual Patients with Established Coronary
Neurologists and Neurosurgeons on the Treatment
Artery Disease: A Concept. Circulation Journal.
of Chronic Subdural Hematoma: A National Survey.
2013;77(3):717-24.
27. Bekkers JA, Raap GB, Takkenberg JJ, Bogers AJ.
Acta Neurol Belg. 2013;113(1):55-9.
33. Bergs JWJ, Krawczyk PM, Borovski T, ten Cate R,
Acute Type a Aortic Dissection: Long-Term Results
Rodermond HM, Stap J, Medema JP, Haveman
and Reoperations. Eur J Cardiothorac Surg.
J, Essers J, van Bree C, Stalpers LJA, Kanaar R,
2013;43(2):389-96.
Aten JA, Franken NAP. Inhibition of Homologous
28. Bekkers JA, te Riele RJ, Takkenberg JJ, Bol
Recombination by Hyperthermia Shunts Early
Raap G, Hofland J, Roos-Hesselink JW, Bogers
Double Strand Break Repair to Non-Homologous
AJ. Thoracic Aortic Surgery: An Overview of 40
Years Clinical Practice. J Thorac Cardiovasc Surg.
End-Joining. DNA Repair. 2013;12(1):38-45.
34. Bernsen MR, Ruggiero A, Van Straten M, Kotek G,
Haeck JC, Wielopolski PA, Krestin GP. Computed
2014;147(1):332-43.
29. Beleigoli AM, Boersma E, Diniz Mde F, Vidigal PG,
Tomography and Magnetic Resonance Imaging.
Lima-Costa MF, Ribeiro AL. C-Reactive Protein
and B-Type Natriuretic Peptide Yield Either a
Recent Results Cancer Res 2013; 187:3-63.
35. Bikker IG, Blankman P, Specht P, Bakker J,
Non-Significant or a Modest Incremental Value
Gommers D. Global and Regional Parameters to
to Traditional Risk Factors in Predicting Long-
Visualize the ‘Best’ Peep During a Peep Trial in a
Term Overall Mortality in Older Adults. PLoS One.
Porcine Model with and without Acute Lung Injury.
2013;8(9):e75809.
30. Beleigoli AM, Ribeiro AL, Diniz Mde F, Lima-
Minerva Anestesiol. 2013;79(9):983-92.
36. Blankman P, Gommers D. Electrical Impedance
Costa MF, Boersma E. The “Obesity Paradox”
Tomography Parameters to Optimize Mechanical
in an Elderly Population with a High Prevalence
Ventilation in Icu Patients. Journal fur Anasthesie
of Chagas Disease: The 10-Year Follow-up of
und Intensivbehandlung. 2013;20(1):5-9.
111
37. Blankman P, Hasan D, Van Mourik MS, Gommers
The Quality of Reporting in Clinical Research: The
D. Ventilation Distribution Measured with Eit at
Consort and Strobe Initiatives. Aging Clinical and
Varying Levels of Pressure Support and Neurally
Experimental Research. 2013;25(1):9-15.
Adjusted Ventilatory Assist in Patients with Ali.
44. Bourantas CV, Garcia-Garcia HM, Diletti R,
Intensive Care Med. 2013;39(6):1057-62.
Muramatsu T, Serruys PW. Early Detection and
38. Blijdorp K, Khajeh L, Ribbers GM, Sneekes EM,
Invasive Passivation of Future Culprit Lesions:
Heijenbrok-Kal MH, van den Berg-Emons HJ, van
A Future Potential or an Unrealistic Pursuit of
der Lely AJ, van Kooten F, Neggers SJ. Diagnostic
Chimeras? Am Heart J. 2013;165(6):869-81.e4.
Value of a Ghrelin Test for the Diagnosis of Gh
45. Bourantas CV, Garcia-Garcia HM, Farooq
Deficiency after Subarachnoid Hemorrhage. Eur J
V, Maehara A, Xu K, Généreux P, Diletti
Endocrinol. 2013;169(4):497-502.
R, Muramatsu T, Fahy M, Weisz G, Stone
39. Blom JW, De Ruijter W, Witteman JCM, Assendelft
GW, Serruys PW. Clinical and Angiographic
WJJ, Breteler MMB, Hofman A, Gussekloo J.
Characteristics of Patients Likely to Have
Changing Prediction of Mortality by Systolic Blood
Vulnerable Plaques: Analysis from the Prospect
Pressure with Increasing Age: The Rotterdam
Study. JACC: Cardiovascular Imaging.
Study. Age. 2013;35(2):431-8.
2013;6(12):1263-72.
40. Boersma E, Van Domburg R, Hoeks S, Kardys
46. Bourantas CV, Garcia-Garcia HM, Naka KK,
I, Lenzen M. Eurointervention - Methodology
Sakellarios A, Athanasiou L, Fotiadis DI, Michalis
and Statistics Review Board. EuroIntervention.
LK, Serruys PW. Hybrid Intravascular Imaging:
2013;9(1):21.
Current Applications and Prospective Potential in
41. Bogers AJ, van de Woestijne PC. How Could Right
the Study of Coronary Atherosclerosis. J Am Coll
Ventricular Outflow Tract Stenting Be Made into
Cardiol. 2013;61(13):1369-78.
One of the Many Small Steps on the Long Road
47. Bourantas CV, Onuma Y, Farooq V, Zhang Y,
to Solid Evidence of Rehabilitation of Pulmonary
Garcia-Garcia HM, Serruys PW. Bioresorbable
Arteries? Eur J Cardiothorac Surg. 2013;44(4):662-
Scaffolds: Current Knowledge, Potentialities and
3.
Limitations Experienced During Their First Clinical
42. Bol K, Haeck JC, Groen HC, Niessen WJ, Bernsen
Applications. Int J Cardiol. 2013;167(1):11-21.
MR, de Jong M, Veenland JF. Can Dce-Mri Explain
48. Bourantas CV, van Mieghem NM, Farooq V,
the Heterogeneity in Radiopeptide Uptake Imaged
Soliman OI, Windecker S, Piazza N, Serruys PW.
by Spect in a Pancreatic Neuroendocrine Tumor
Future Perspectives in Transcatheter Aortic Valve
Model? PLoS One. 2013;8(10):e77076
Implantation. Int J Cardiol. 2013;168(1):11-8.
43. Bolignano D, Mattace-Raso F, Torino C, D’Arrigo G,
49. Bourantas CV, Van Mieghem NM, Soliman O,
Elhafeez SA, Provenzano F, Zoccali C, Tripepi G.
Campos CA, Iqbal J, Serruys PW. Transcatheter
112
Aortic Valve Update 2013. EuroIntervention. 2013;9
Der Ploeg AT. Mucopolysaccharidosis: Cardiologic
Suppl:S84-90.
Features and Effects of Enzyme-Replacement
50. Bouvy JC, Fransen PSS, Baeten SA,
Therapy in 24 Children with Mps I, Ii and Vi. J
Koopmanschap MA, Niessen LW, Dippel DWJ.
Inherit Metab Dis. 2013;36(2):227-34.
Cost-Effectiveness of Two Endovascular Treatment
56. Bron EE, Van Tiel J, Smit H, Poot DHJ, Niessen
Strategies Vs Intravenous Thrombolysis. Acta
WJ, Krestin GP, Weinans H, Oei EHG, Kotek G,
Neurol Scand. 2013;127(5):351-9.
Klein S. Image Registration Improves Human Knee
51. Boven NV, Bogaard K, Ruiter J, Kimman G, Theuns
Cartilage T1 Mapping with Delayed Gadolinium-
D, Kardys I, Umans V. Functional Response to
Enhanced Mri of Cartilage (Dgemric). Eur Radiol.
Cardiac Resynchronization Therapy Is Associated
2013;23(1):246-52.
with Improved Clinical Outcome and Absence of
57. Brugada J, Blom N, Sarquella-Brugada G,
Appropriate Shocks. J Cardiovasc Electrophysiol.
Blomstrom-Lundqvist C, Deanfield J, Janousek
2013;24(3):316-22.
J, Abrams D, Bauersfeld U, Brugada R, Drago F,
52. Boyé NDA, Oudshoorn C, Van Der Velde N, Van
De Groot N, Happonen JM, Hebe J, Yen Ho S,
Lieshout EMM, De Vries OJ, Lips P, Van Beeck EF,
Marijon E, Paul T, Pfammatter JP, Rosenthal E.
Patka P, Van Der Cammen TJM. Vitamin D and
Pharmacological and Non-Pharmacological Therapy
Physical Performance in Older Men and Women
for Arrhythmias in the Pediatric Population: Ehra and
Visiting the Emergency Department Because
Aepc-Arrhythmia Working Group Joint Consensus
of a Fall: Data from the Improving Medication
Statement. Europace. 2013;15(9):1337-82.
Prescribing to Reduce Risk of Falls (Improvefall)
58. Brugaletta S, Garcia-Garcia HM, Gomez-Lara
Study. J Am Geriatr Soc. 2013;61(11):1948-52.
J, Radu MD, Pawar R, Khachabi J, Bruining
53. Boyé NDA, Van Lieshout EMM, Van Beeck EF,
N, Sabaté M, Serruys PW. Reproducibility of
Hartholt KA, Van Der Cammen TJM, Patka P.
Qualitative Assessment of Stent Struts Coverage
The Impact of Falls in the Elderly. Trauma (United
by Optical Coherence Tomography. International
Kingdom). 2013;15(1):29-35.
Journal of Cardiovascular Imaging. 2013;29(1):5-
54. Brands M, Roelants J, de Krijger R, Bogers
A, Reuser A, van der Ploeg A, Helbing W.
11.
59. Brugaletta S, Sabate M, Martin-Yuste V, Masotti
Macrophage Involvement in Mitral Valve
M, Shiratori Y, Alvarez-Contreras L, Cequier A,
Pathology in Mucopolysaccharidosis Type Vi
Iniguez A, Serra A, Hernandez-Antolin R, Mainar V,
(Maroteaux-Lamy Syndrome). Am J Med Genet A.
Valgimigli M, Tespili M, den Heijer P, Bethencourt
2013;161(10):2550-3.
A, Vazquez N, Gomez-Lara J, Backx B, Serruys
55. Brands MMMG, Frohn-Mulder IM, Hagemans
PW. Predictors and Clinical Implications of
MLC, Hop WCJ, Oussoren E, Helbing WA, Van
Stent Thrombosis in Patients with St-Segment
113
Elevation Myocardial Infarction: Insights from the
AJJC, Hoerstrup SP, Baaijens FPT. Mechanical
Examination Trial. Int J Cardiol. 2013;168(3):2632-
Analysis of Ovine and Pediatric Pulmonary
6.
Artery for Heart Valve Stent Design. J Biomech.
60. Bruining N. The Diabetes Conundrum: Despite
2013;46(12):2075-81.
Increasing Incidences of Coronary Disease in
65. Campos CAM, Zhang YJ, Bourantas CV,
Diabetic Type Ii Patients, Their First Cathlab
Muramatsu T, Garcia-Garcia HM, Lemos PA, Iqbal
Presentation Is Later Than Expected. Eur Heart J.
J, Onuma Y, Serruys PW. Bioresorbable Vascular
2013;34(10):715-8.
Scaffolds in the Clinical Setting. Interventional
61. Bullock JM, Medway C, Cortina-Borja M, Turton
Cardiology (London). 2013;5(6):639-46.
JC, Prince JA, Ibrahim-Verbaas CA, Schuur M,
66. Campos CM, Muramatsu T, Iqbal J, Zhang YJ,
Breteler MM, van Duijn CM, Kehoe PG, Barber
Onuma Y, Garcia-Garcia HM, Haude M, Lemos
R, Coto E, Alvarez V, Deloukas P, Hammond N,
PA, Warnack B, Serruys PW. Bioresorbable Drug-
Combarros O, Mateo I, Warden DR, Lehmann MG,
Eluting Magnesium-Alloy Scaffold for Treatment of
Belbin O, Brown K, Wilcock GK, Heun R, Kölsch
Coronary Artery Disease. International Journal of
H, Smith AD, Lehmann DJ, Morgan K. Discovery
Molecular Sciences. 2013;14(12):24492-500.
by the Epistasis Project of an Epistatic Interaction
67. Chai CK, Akyildiz AC, Speelman L, Gijsen FJ,
between the Gstm3 Gene and the Hhex/Ide/
Oomens CW, van Sambeek MR, van der Lugt A,
Kif11 Locus in the Risk of Alzheimer’s Disease.
Baaijens FP. Local Axial Compressive Mechanical
Neurobiol Aging. 2013;34(4):1309.e1-.e7.
Properties of Human Carotid Atherosclerotic
62. Bussink BE, Holst AG, Jespersen L, Deckers JW,
Plaques-Characterisation by Indentation Test
Jensen GB, Prescott E. Right Bundle Branch Block:
and Inverse Finite Element Analysis. J Biomech.
Prevalence, Risk Factors, and Outcome in the
General Population: Results from the Copenhagen
2013;46(10):1759-66.
68. Chan MY, Sun JL, Newby LK, Lokhnygina Y,
City Heart Study. Eur Heart J. 2013;34(2):138-46.
White HD, Moliterno DJ, Théroux P, Ohman EM,
63. Cabrera JA, Butterick TA, Long EK, Ziemba EA,
Simoons ML, Mahaffey KW, Pieper KS, Giugliano
Anderson LB, Duffy CM, Sluiter W, Duncker DJ,
RP, Armstrong PW, Califf RM, Van De Werf F,
Zhang J, Chen Y, Ward HB, Kelly RF, McFalls EO.
Harrington RA. Trends in Clinical Trials of Non-St-
Reduced Expression of Mitochondrial Electron
Segment Elevation Acute Coronary Syndromes
Transport Chain Proteins from Hibernating Hearts
Relative to Ischemic Preconditioned Hearts in the
over 15 Years. Int J Cardiol. 2013;167(2):548-54.
69. Cheng C, Chrifi I, Pasterkamp G, Duckers HJ.
Second Window of Protection. J Mol Cell Cardiol.
Biological Mechanisms of Microvessel Formation
2013;60(1):90-6.
in Advanced Atherosclerosis: The Big Five. Trends
64. Cabrera MS, Oomens CWJ, Bouten CVC, Bogers
Cardiovasc Med. 2013;23(5):153-64.
114
70. Cheng JM, Akkerhuis KM, Battes LC, Van Vark
75. Chitsaz S, Wenk JF, Ge L, Wisneski A, Mookhoek
LC, Hillege HL, Paulus WJ, Boersma E, Kardys I.
A, Ratcliffe MB, Guccione JM, Tseng EE. Material
Biomarkers of Heart Failure with Normal Ejection
Properties of Corcap Passive Cardiac Support
Fraction: A Systematic Review. European Journal
Device. Ann Thorac Surg. 2013;95(1):148-54.
76. Cornet AD, Hofstra JJ, Vlaar AP, Tuinman PR,
of Heart Failure. 2013;15(12):1350-62.
71. Cheng JM, Van Leeuwen MAH, De Boer SPM, Wai
Levi M, Girbes AR, Schultz MJ, Groeneveld AB,
MCGTJ, Den Uil CA, Jewbali LSD, Van Geuns RJ,
Beishuizen A. Activated Protein C Attenuates
Kardys I, Van Domburg RT, Boersma E, Zijlstra
Pulmonary Coagulopathy in Patients with Acute
F, Akkerhuis KM. Impact of Intra-Aortic Balloon
Respiratory Distress Syndrome. Journal of
Pump Support Initiated before Versus after Primary
Thrombosis and Haemostasis. 2013;11(5):894-901.
Percutaneous Coronary Intervention in Patients
77. Cornette J, Ruys TP, Roos-Hesselink JW.
with Cardiogenic Shock from Acute Myocardial
Assessment of the Right Ventricle in Pregnant
Infarction. Int J Cardiol. 2013;168(4):3758-63.
Women with and without Structural Heart Disease.
72. Cherpanath TGV, Lagrand WK, Schultz MJ,
Int J Cardiol. 2013;168(3):3087.
Groeneveld ABJ. Cardiopulmonary Interactions
78. Cornette J, Ruys TPE, Rossi A, Rizopoulos
During Mechanical Ventilation in Critically
D, Takkenberg JJM, Karamermer Y, Opić P,
Ill Patients. Netherlands Heart Journal.
Van Den Bosch AE, Geleijnse ML, Duvekot JJ,
2013;21(4):166-72.
Steegers EAP, Roos-Hesselink JW. Hemodynamic
73. Cheung YM, Scoones GP, Hoeks SE, Stolker
Adaptation to Pregnancy in Women with Structural
RJ, Weber F. Evaluation of the Aepex Monitor of
Heart Disease. Int J Cardiol. 2013;168(2):825-31.
Hypnotic Depth in Pediatric Patients Receiving
79. Costet P, Ehrenborg E, Fisher R, Fielding B, Groen
Propofol-Remifentanil Anesthesia. Paediatr
A, Kardassis D, Malle E, Mulder M, Niemeier A,
Anaesth. 2013;23(10):891-7.
Norata GD, Hansen AT, Eckardstein A. European
74. Chieffo A, Buchanan GL, Van Mieghem NM,
Lipoprotein Club: Report of the 35th Elc Annual
Tchetche D, Dumonteil N, Latib A, Van Der
Conference (Tutzing, 10th-13th September 2012).
Boon RMA, Vahdat O, Marcheix B, Farah B,
Atherosclerosis. 2013;226(2):510-6.
Serruys PW, Fajadet J, Carrié D, De Jaegere
80. Cummins P, Serruys PW. Esc Journals Working
PPT, Colombo A. Transcatheter Aortic Valve
Together. EuroIntervention. 2013;9(6):655.
Implantation with the Edwards Sapien Versus the
81. Cummins P, Serruys PW. The Journal Citation
Medtronic Corevalve Revalving System Devices:
Reports Impact Factor: Annual Results 2012.
A Multicenter Collaborative Study: The Pragmatic
EuroIntervention. 2013;9(3):294-5.
Plus Initiative (Pooled-Rotterdam-Milano-Toulouse in
82. Cuypers JA, Witsenburg M, van der Linde D,
Collaboration). J Am Coll Cardiol. 2013;61(8):830-6.
Roos-Hesselink JW. Pulmonary Stenosis: Update
115
on Diagnosis and Therapeutic Options. Heart.
Associated with 7-Year Mortality in Patients
2013;99(5):339-47.
Treated with Percutaneous Coronary Intervention:
83. Cuypers JAAE, Opić P, Menting ME, Utens EMWJ,
Results from the Research Registry. Int J Cardiol.
Witsenburg M, Helbing WA, Van Den Bosch AE,
Ouhlous M, Van Domburg RT, Meijboom FJ,
2013;167(6):2496-501.
90. Damman P, Kampinga MA, Van Der Horst ICC,
Bogers AJJC, Roos-Hesselink JW. The Unnatural
Woudstra P, Grundeken MJ, Kuijt WJ, Harskamp
History of an Atrial Septal Defect: Longitudinal 35
RE, Nijsten MWN, Zijlstra F, Tijssen JGP, De Smet
Year Follow up after Surgical Closure at Young
BJGL, De Winter RJ. Multiple Biomarkers for the
Age. Heart. 2013;99(18):1346-52.
Prediction of Short and Long-Term Mortality after
84. Daemen J. Current Technologies: An Introduction.
St-Segment Elevation Myocardial Infarction: The
Amsterdam Groningen Collaboration. J Thromb
EuroIntervention. 2013;9 Suppl R:R75-82.
85. Daemen J. Diastolic Dysfunction and Arterial
Stiffness: The Chicken or the Egg. Neth Heart J.
Thrombolysis. 2013;36(1):42-6.
91. Dangas GD, Serruys PW, Kereiakes DJ, Hermiller
J, Rizvi A, Newman W, Sudhir K, Smith Jr RS,
2013;21(5):219-21.
86. Daemen J, Mahfoud F. Renal Denervation:
Cao S, Theodoropoulos K, Cutlip DE, Lansky AJ,
Expanding the Indication. EuroIntervention. 2013;9
Stone GW. Meta-Analysis of Everolimus-Eluting
Suppl R:R101-4.
Versus Paclitaxel-Eluting Stents in Coronary Artery
87. Damen NL, Pelle AJ, Boersma E, Serruys PW,
Disease: Final 3-Year Results of the Spirit Clinical
Van Domburg RT, Pedersen SS. Reduced Positive
Trials Program (Clinical Evaluation of the Xience
Affect (Anhedonia) Is Independently Associated
V Everolimus Eluting Coronary Stent System in
with 7-Year Mortality in Patients Treated with
the Treatment of Patients with De Novo Native
Percutaneous Coronary Intervention: Results
Coronary Artery Lesions). JACC: Cardiovascular
from the Research Registry. European Journal of
Interventions. 2013;6(9):914-22.
Preventive Cardiology. 2013;20(1):127-34.
92. Danilouchkine MG, Van Neer PLMJ, Verweij MD,
88. Damen NL, Versteeg H, Boersma E, De Jaegere
Matte GM, Vletter WB, Van Der Steen AFW, De
PP, Van Geuns RJM, Van Domburg RT, Pedersen
Jong N. Single Pulse Frequency Compounding
SS. Indication for Percutaneous Coronary
Protocol for Superharmonic Imaging. Phys Med
Intervention Is Not Associated with Symptoms
Biol. 2013;58(14):4791-805.
of Anxiety and Depression. Int J Cardiol.
93. De Bacquer D, Dallongeville J, Kotseva K, Cooney
MT, Pajak A, Deckers JW, Mayer O, Vanuzzo
2013;168(5):4897-8.
89. Damen NL, Versteeg H, Boersma E, Serruys
D, Lehto S, Fras Z, Ostor E, Ambrosio GB, De
PW, Van Geuns RJM, Denollet J, Van Domburg
Backer G, Wood D, Keil U, Sans S, Graham
RT, Pedersen SS. Depression Is Independently
I, Pyörälä K. Residual Risk of Cardiovascular
116
Mortality in Patients with Coronary Heart Disease:
Temporal Analysis of Molecular Determinants
The Euroaspire Risk Categories. Int J Cardiol.
of Neuronal Degeneration in the Aging Mouse
2013;168(2):910-4.
Cerebellum. Molecular and Cellular Proteomics.
94. De Beer VJ, Merkus D, Bender SB, Tharp DL,
2013;12(5):1350-62.
Bowles DK, Duncker DJ, Laughlin MH. Familial
100. De Groot M, Verhaaren BFJ, De Boer R, Klein S,
Hypercholesterolemia Impairs Exercise-Induced
Hofman A, Van Der Lugt A, Ikram MA, Niessen WJ,
Systemic Vasodilation Due to Reduced No
Vernooij MW. Changes in Normal-Appearing White
Bioavailability. J Appl Physiol. 2013;115(12):1767-76.
Matter Precede Development of White Matter
95. de Boer SP, van Leeuwen MA, Cheng JM,
Lesions. Stroke. 2013;44(4):1037-42.
Oemrawsingh RM, van Geuns RJ, Serruys PW,
101. De Groot M, Vernooij MW, Klein S, Ikram MA,
Boersma E, Lenzen MJ. Trial Participation as a
Vos FM, Smith SM, Niessen WJ, Andersson
Determinant of Clinical Outcome: Differences
JLR. Improving Alignment in Tract-Based Spatial
between Trial-Participants and Every Day Clinical
Statistics: Evaluation and Optimization of Image
Care Patients in the Field of Interventional
Registration. Neuroimage. 2013;76:400-11.
Cardiology. Int J Cardiol. 2013;169(4):305-10.
102. de Groot NMS. Remote Magnetic Catheter
96. De Boer SPM, Serruys PWJC, Valstar G,
Navigation: More Than Just Bells and Whistles?
Lenzen MJ, De Jaegere PJ, Zijlstra F, Boersma
Netherlands Heart Journal. 2013;21(6):294-5.
E, Van Domburg RT. Life-Years Gained by
103. De Koning WB, Van Osch-Gevers LM, Robbers-
Smoking Cessation after Percutaneous Coronary
Visser D, Van Domburg RT, Bogers AJJC, Helbing
Intervention. Am J Cardiol. 2013;112(9):1311-4.
WA. Enlarged Right Ventricular Size at 11 Years’
97. De Bruijn RFAG, Schrijvers EMC, De Groot KA,
Follow-up after Closure of Secundum-Type
Witteman JCM, Hofman A, Franco OH, Koudstaal
Atrial Septal Defect in Children. Cardiol Young.
PJ, Ikram MA. The Association between Physical
2013;23(1):7-13.
Activity and Dementia in an Elderly Population: The
104. De Mulder M, Umans VA, Cornel JH, Van Der
Rotterdam Study. Eur J Epidemiol. 2013;28(3):277-
Zant FM, Stam F, Oemrawsingh RM, Akkerhuis
83.
KM, Boersma E. Intensive Glucose Regulation
98. De Geus HRH, Betjes MG, Van Schaick R,
in Hyperglycemic Acute Coronary Syndrome:
Groeneveld JABJ. Plasma Ngal Similarly Predicts
Results of the Randomized Biomarker Study to
Acute Kidney Injury in Sepsis and Nonsepsis.
Identify the Acute Risk of a Coronary Syndrome-2
Biomarkers in Medicine. 2013;7(3):415-21.
(Biomarcs-2) Glucose Trial. JAMA Internal
99. De Graaf EL, Vermeij WP, De Waard MC,
Rijksen Y, Van Der Pluijm I, Hoogenraad CC,
Medicine. 2013;173(20):1896-904.
105. De Ridder I, Den Hertog H, Van Gemert M, Dippel
Hoeijmakers JHJ, Altelaar AFM, Heck AJR. Spatio-
D, Van Der Worp B. Increased Benefit of Alteplase
117
in Patients with Ischemic Stroke and a High Body
Calcium Scanning or Exercise Electrocardiography.
Temperature. Cerebrovasc Dis. 2013;35(1):60-3.
Int J Cardiol. 2013;163(2):190-5.
106. De Ridder I, Dirks M, Niessen L, Dippel D. Unequal
113. Dedic A, Ten Kate GJ, Neefjes LA, Rossi A,
Access to Treatment with Intravenous Alteplase
Dharampal A, Rood PPM, Galema TW, Schultz C,
for Women with Acute Ischemic Stroke. Stroke.
Ouhlous M, Moelker A, De Feyter PJ, Nieman K.
2013;44(9):2610-2.
Coronary Ct Angiography Outperforms Calcium
107. De Roy LJM, Goethals P, Jordaens LJL. Do We
Imaging in the Triage of Acute Coronary Syndrome.
Need More or Better Electrophysiology Centres?
Int J Cardiol. 2013;167(4):1597-602.
114. Dedic A, Ten Kate GJ, Rood PPM, Galema TW,
Europace. 2013;15(12):1687-9.
108. De Waha A, Stefanini GG, King LA, Byrne RA,
Ouhlous M, Moelker A, De Feyter PJ, De Rijke
Serruys PW, Kufner S, Meier B, Jüni P, Kastrati
YB, Nieman K. Copeptin in Acute Chest Pain:
A, Windecker S. Long-Term Outcomes of
Identification of Acute Coronary Syndrome and
Biodegradable Polymer Versus Durable Polymer
Obstructive Coronary Artery Disease on Coronary
Drug-Eluting Stents in Patients with Diabetes a
Ct Angiography. Emergency Medicine Journal.
Pooled Analysis of Individual Patient Data from 3
2013;30(11):910-3.
Randomized Trials. Int J Cardiol. 2013;168(6):5162-
115. Dehghan A, Leening MJ, Solouki AM, Boersma E,
Deckers JW, van Herpen G, Heeringa J, Hofman
6.
109. Deckers JW. Classification of Myocardial Infarction
A, Kors JA, Franco OH, Ikram MA, Witteman JC.
and Unstable Angina: A Re-Assessment. Int J
Comparison of Prognosis in Unrecognized Versus
Cardiol. 2013;167(6):2387-90.
Recognized Myocardial Infarction in Men Versus
110. Deckers JW, Van Domburg RT, Akkerhuis M,
Women >55 Years of Age (from the Rotterdam
Nauta ST. Relation of Admission Glucose Levels,
Study). Am J Cardiol. 2014;113(1):1-6.
Short- and Long-Term (20-Year) Mortality after
116. Delewi R, Andriessen A, Tijssen JGP, Zijlstra F,
Acute Myocardial Infarction. Am J Cardiol.
Piek JJ, Hirsch A. Impact of Intracoronary Cell
2013;112(9):1306-10.
Therapy on Left Ventricular Function in the Setting
111. Dedic A, Genders TS, Nieman K, Hunink MGM.
of Acute Myocardial Infarction: A Meta-Analysis
Imaging Strategies for Acute Chest Pain in the
of Randomised Controlled Clinical Trials. Heart.
Emergency Department. Am J Roentgenol.
2013;99(4):225-32.
117. Delewi R, IJff G, Van De Hoef TP, Hirsch A,
2013;200(1):W26-W38.
112. Dedic A, Rossi A, Ten Kate GJR, Neefjes LA,
Robbers LF, Nijveldt R, Van Der Laan AM, Van
Galema TW, Moelker A, Van Domburg RT, Schultz
Der Vleuten PA, Lucas C, Tijssen JGP, Van
CJ, Mollet NR, De Feyter PJ, Nieman K. First-Line
Rossum AC, Zijlstra F, Piek JJ. Pathological Q
Evaluation of Coronary Artery Disease with Coronary
Waves in Myocardial Infarction in Patients Treated
118
by Primary Pci. JACC: Cardiovascular Imaging.
123. Diletti R, Farooq V, Girasis C, Bourantas C, Onuma
Y, Heo JH, Gogas BD, van Geuns RJ, Regar E,
2013;6(3):324-31.
118. Demirdas S, Maurice-Stam H, Boelen CCA,
de Bruyne B, Dudek D, Thuesen L, Chevalier B,
Hofstede FC, Janssen MCH, Langendonk JG,
McClean D, Windecker S, Whitbourn RJ, Smits
Mulder MF, Rubio-Gozalbo ME, van Spronsen
P, Koolen J, Meredith I, Li X, Miquel-Hebert K,
FJ, de Vries M, Grootenhuis MA, Bosch AM.
Veldhof S, Garcia-Garcia HM, Ormiston JA,
Evaluation of Quality of Life in Pku before and
Serruys PW. Clinical and Intravascular Imaging
after Introducing Tetrahydrobiopterin (Bh4); a
Outcomes at 1 and 2 Years after Implantation
Prospective Multi-Center Cohort Study. Mol Genet
of Absorb Everolimus Eluting Bioresorbable
Metab. 2013;110(SUPPL.):S49-S56.
Vascular Scaffolds in Small Vessels. Late Lumen
119. Devore EE, Feskens E, Ikram MA, Den Heijer T,
Enlargement: Does Bioresorption Matter with Small
Vernooij M, Van Der Lijn F, Hofman A, Niessen
Vessel Size? Insight from the Absorb Cohort B
WJ, Breteler MMB. Total Antioxidant Capacity of
Trial. Heart. 2013;99(2):98-105.
the Diet and Major Neurologic Outcomes in Older
124. Diletti R, Garcia-Garcia HM, Bourantas CV,
Adults. Neurology. 2013;80(10):904-10.
Van Geuns RJ, Van Mieghem NM, Agostoni P,
120. Dharampal AS, de Feyter PJ. Coronary Artery
Muramatsu T, Farooq V, Spencer R, De Schepper
Calcification: Does It Predict Obstructive Coronary
J, Pomeranz M, Stella P, Serruys PW. Clinical and
Artery Disease? Neth Heart J. 2013;21(7-8):344-6.
Angiographic Outcomes Following First-in-Man
121. Dharampal AS, Papadopoulou SL, Rossi A,
Implantation of a Novel Thin-Strut Low-Profile
Meijboom WB, Weustink A, Dijkshoorn M, Nieman
Fixed-Wire Stent: The Svelte Coronary Stent
K, Boersma EH, De Feijter PJ, Krestin GP.
Integrated Delivery System First-in-Man Trial.
Diagnostic Performance of Computed Tomography
Coronary Angiography to Detect and Exclude
125. Diletti R, Garcia-Garcia HM, Bourantas CV, Van
Left Main and/or Three-Vessel Coronary Artery
Geuns RJ, Van Mieghem NM, Vranckx P, Zhang
Disease. Eur Radiol. 2013;23(11):2934-43.
YJ, Farooq V, Iqbal J, Wykrzykowska JJ, De Vries
122. Dharampal AS, Rossi A, Dedic A, Cademartiri
T, Swart M, Teunissen Y, Negoita M, Van Leeuwen
F, Papadopoulou SL, Weustink AC, Ferket BS,
F, Silber S, Windecker S, Serruys PW. Clinical
Boersma E, Meijboom WB, Galema TW, Nieman K,
Outcomes after Zotarolimus and Everolimus Drug
de Feyter PJ, Krestin GP. Restriction of the Referral
Eluting Stent Implantation in Coronary Artery
of Patients with Stable Angina for Ct Coronary
Bifurcation Lesions: Insights from the Resolute All
Angiography by Clinical Evaluation and Calcium
Comers Trial. Heart. 2013;99(17):1267-74.
Score: Impact on Clinical Decision Making. Eur
126. Dippel DWJ, Boiten J, Vos JA, Majoie CB. IntraArterial Treatment of Ischemic Stroke - Still No
Radiol. 2013(10):2676-86.
119
Evidence but Reason for Further Study. Intra-
Lehtimäki T, Lin SY, Lindström J, Loos RJF, Mach
arteriële behandeling van het herseninfarct: Nog
F, McArdle WL, Meisinger C, Mitchell BD, Müller
geen bewijs, maar wel reden voor verder onder
G, Nagaraja R, Narisu N, Nieminen TVM, Nsubuga
zoek. Ned Tijdschrift Geneesk 2013;157(38):A6409
RN, Olafsson I, Ong KK, Palotie A, Papamarkou
127. Dirks M, Dippel DWJ. Implementation of
T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker
Thrombolysis for Ischaemic Stroke. The Lancet
PM, Rivadeneira F, Rudan I, Ruokonen A, Samani
Neurology. 2013;12(2):120-1.
N, Scharnagl H, Seeley J, Silander K, Stancáková
128. Do R, Willer CJ, Schmidt EM, Sengupta S, Gao
A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, Van
C, Peloso GM, Gustafsson S, Kanoni S, Ganna
Pelt LJ, Vedantam S, Wainwright N, Wijmenga C,
A, Chen J, Buchkovich ML, Mora S, Beckmann
Wild SH, Willemsen G, Wilsgaard T, Wilson JF,
JS, Bragg-Gresham JL, Chang HY, Demirkan A,
Young EH, Zhao JH, Adair LS, Arveiler D, Assimes
Den Hertog HM, Donnelly LA, Ehret GB, Esko T,
TL, Bandinelli S, Bennett F, Bochud M, Boehm BO,
Feitosa MF, Ferreira T, Fischer K, Fontanillas P,
Boomsma DI, Borecki IB, Bornstein SR, Bovet P,
Fraser RM, Freitag DF, Gurdasani D, Heikkilä K,
Burnier M, Campbell H, Chakravarti A, Chambers
Hyppönen E, Isaacs A, Jackson AU, Johansson Å,
JC, Chen YDI, Collins FS, Cooper RS, Danesh J,
Johnson T, Kaakinen M, Kettunen J, Kleber ME,
Dedoussis G, De Faire U, Feranil AB, Ferrières
Li X, Luan J, Lyytikäinen LP, Magnusson PKE,
J, Ferrucci L, Freimer NB, Gieger C, Groop LC,
Mangino M, Mihailov E, Montasser ME, Müller-
Gudnason V, Gyllensten U, Hamsten A, Harris TB,
Nurasyid M, Nolte IM, O’Connell JR, Palmer CD,
Hingorani A, Hirschhorn JN, Hofman A, Hovingh
Perola M, Petersen AK, Sanna S, Saxena R,
GK, Hsiung CA, Humphries SE, Hunt SC, Hveem
Service SK, Shah S, Shungin D, Sidore C, Song
K, Iribarren C, Järvelin MR, Jula A, Kähönen M,
C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich
Kaprio J, Kesäniemi A, Kivimaki M, Kooner JS,
TM, Thorleifsson G, Van Den Herik EG, Voight
Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J,
BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W,
Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren
Absher D, Asiki G, Barroso I, Been LF, Bolton JL,
CM, Martin NG, März W, McCarthy MI, McKenzie
Bonnycastle LL, Brambilla P, Burnett MS, Cesana
CA, Meneton P, Metspalu A, Moilanen L, Morris
G, Dimitriou M, Doney ASF, Döring A, Elliott P,
AD, Munroe PB, Njølstad I, Pedersen NL, Power C,
Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi
Pramstaller PP, Price JF, Psaty BM, Quertermous
MO, Grallert H, Gravito ML, Groves CJ, Hallmans
T, Rauramaa R, Saleheen D, Salomaa V,
G, Hartikainen AL, Hayward C, Hernandez D,
Sanghera DK, Saramies J, Schwarz PEH, Sheu
Hicks AA, Holm H, Hung YJ, Illig T, Jones MR,
WHH, Shuldiner AR, Siegbahn A, Spector TD,
Kaleebu P, Kastelein JJP, Khaw KT, Kim E, Klopp
Stefansson K, Strachan DP, Tayo BO, Tremoli
N, Komulainen P, Kumari M, Langenberg C,
E, Tuomilehto J, Uusitupa M, Van Duijn CM,
120
Vollenweider P, Wallentin L, Wareham NJ, Whitfield
of Human Erythroid-Specific 5-Aminolevulinic
JB, Wolffenbuttel BHR, Altshuler D, Ordovas JM,
Synthase Associated with X-Linked Dominant
Boerwinkle E, Palmer CNA, Thorsteinsdottir U,
Protoporphyria (Xldpp). Hum Mol Genet.
Chasman DI, Rotter JI, Franks PW, Ripatti S,
Cupples LA, Sandhu MS, Rich SS, Boehnke M,
2013;22(7):1280-8.
133. Dumonteil N, van der Boon RM, Tchetche
Deloukas P, Mohlke KL, Ingelsson E, Abecasis
D, Chieffo A, Van Mieghem NM, Marcheix B,
GR, Daly MJ, Neale BM, Kathiresan S. Common
Buchanan GL, Vahdat O, Serruys PW, Fajadet
Variants Associated with Plasma Triglycerides
J, Colombo A, de Jaegere PP, Carrie D. Impact
and Risk for Coronary Artery Disease. Nat Genet.
of Preoperative Chronic Kidney Disease
2013;45(11):1345-53.
on Short- and Long-Term Outcomes after
129. Dominici M, Diletti R, Milici C, Bock C, Placanica
Transcatheter Aortic Valve Implantation: A Pooled-
A, D’Alessandro G, Arrivi A, Italiani M, Buono E,
Rotterdam-Milano-Toulouse in Collaboration Plus
Boschetti E. Operator Exposure to X-Ray in Left
(Pragmatic-Plus) Initiative Substudy. Am Heart J.
and Right Radial Access During Percutaneous
2013;165(5):752-60.
Coronary Procedures: Opera Randomised Study.
134. Dunning J, Nagendran M, Alfieri OR, Elia S,
Kappetein AP, Lockowandt U, Sarris GE, Kolh
Heart. 2013;99(7):480-4.
130. Döpp-Zemel D, Groeneveld J. High-Dose
PH. Guideline for the Surgical Treatment of
Norepinephrine Treatment: Determinants of
Atrial Fibrillation. Eur J Cardiothorac Surg.
Mortality and Futility in Critically Ill Patients. Am J
2013;44(5):777-91.
Crit Care. 2013;22(1):22-32.
135. Dunser MW, Takala J, Brunauer A, Bakker J. Re-
131. Dorresteijn JAN, Schrover IM, Visseren FLJ,
Thinking Resuscitation: Leaving Blood Pressure
Scheffer PG, Liam Oey P, Jan Danser AH, Spiering
Cosmetics Behind and Moving Forward to
W. Differential Effects of Renin-Angiotensin-
Permissive Hypotension and a Tissue Perfusion-
Aldosterone System Inhibition, Sympathoinhibition
and Diuretic Therapy on Endothelial Function and
Based Approach. Crit Care. 2013;17(5):326.
136. Duppen N, Takken T, Hopman MT, ten Harkel
Blood Pressure in Obesity-Related Hypertension: A
AD, Dulfer K, Utens EM, Helbing WA. Systematic
Double-Blind, Placebo-Controlled Cross-over Trial.
Review of the Effects of Physical Exercise Training
J Hypertens. 2013;31(2):393-403.
Programmes in Children and Young Adults
132. Ducamp S, Schneider-Yin X, de Rooij F, Clayton
with Congenital Heart Disease. Int J Cardiol.
J, Fratz EJ, Rudd A, Ostapowicz G, Varigos G,
Lefebvre T, Deybach JC, Gouya L, Wilson P,
2013;168(3):1779-87.
137. Dwarkasing RS, Schouten WR, Geeraedts TE,
Ferreira GC, Minder EI, Puy H. Molecular and
Mitalas LE, Hop WC, Krestin GP. Chronic Anal
Functional Analysis of the C-Terminal Region
and Perianal Pain Resolved with Mri. AJR Am J
121
Prognostic Implications of Circulating Pentraxin
Roentgenol. 2013;200(5):1034-41.
138. Eckhardt CL, Van Velzen AS, Peters M, Astermark
3 Levels in Non St-Elevation Acute Coronary
J, Brons PP, Castaman G, Cnossen MH, Dors N,
Escuriola-Ettingshausen C, Hamulyak K, Hart DP,
Syndrome. Clin Biochem. 2013;46(16-17):1655-9.
142. Eikelboom JW, Connolly SJ, Brueckmann M,
Hay CRM, Haya S, Van Heerde WL, Hermans
Granger CB, Kappetein AP, Mack MJ, Blatchford
C, Holmström M, Jimenez-Yuste V, Keenan RD,
J, Devenny K, Friedman J, Guiver K, Harper R,
Klamroth R, Laros-van Gorkom BAP, Leebeek
Khder Y, Lobmeyer MT, Maas H, Voigt JU, Simoons
FWG, Liesner R, Mäkipernaa A, Male C, Mauser-
ML, Van De Werf F. Dabigatran Versus Warfarin in
Bunschoten E, Mazzucconi MG, McRae S, Meijer
Patients with Mechanical Heart Valves. N Engl J
K, Mitchell M, Morfini M, Nijziel M, Oldenburg
Med. 2013;369(13):1206-14.
J, Peerlinck K, Petrini P, Platokouki H, Reitter-
143. Eindhoven JA, Van Den Bosch AE, Boersma E,
Pfoertner SE, Santagostino E, Schinco P, Smiers
Roos-Hesselink JW. The Usefulness of Brain
FJ, Siegmund B, Tagliaferri A, Yee TT, Kamphuisen
Natriuretic Peptide in Simple Congenital Heart
PW, Van Der Bom JG, Fijnvandraat K. Factor
Disease-a Systematic Review. Cardiol Young.
Viii Gene (F8) Mutation and Risk of Inhibitor
Development in Nonsevere Hemophilia A. Blood.
2013;23(3):315-24.
144. Eindhoven JA, Van Den Bosch AE, Boersma E,
Roos-Hesselink JW. Reply. J Am Coll Cardiol.
2013;122(11):1954-62.
139. Ederle J, Davagnanam I, van der Worp HB,
Venables GS, Lyrer PA, Featherstone RL, Brown
2013;61(19):2023-4.
145. Eindhoven JA, Van Den Bosch AE, Ruys TPE,
MM, Jager HR, investigators I. Effect of White-
Opić P, Cuypers JAAE, McGhie JS, Witsenburg M,
Matter Lesions on the Risk of Periprocedural
Boersma E, Roos-Hesselink JW. N-Terminal Pro-B-
Stroke after Carotid Artery Stenting Versus
Type Natriuretic Peptide and Its Relationship with
Endarterectomy in the International Carotid
Cardiac Function in Adults with Congenital Heart
Stenting Study (Icss): A Prespecified Analysis of
Data from a Randomised Trial. Lancet Neurol.
Disease. J Am Coll Cardiol. 2013;62(13):1203-12.
146. El Hachioui H, Lingsma HF, Van De SandtKoenderman ME, Dippel DWJ, Koudstaal PJ,
2013;12(9):866-72.
140. Eefting D, Ultee KHJ, Von Meijenfeldt GCI, Hoeks
Visch-Brink EG. Recovery of Aphasia after
SE, Ten Raa S, Hendriks JM, Bastos Goncalves
Stroke: A 1-Year Follow-up Study. J Neurol.
F, Verhagen HJM. Ruptured Aaa: State of the
Art Management. J Cardiovasc Surg (Torino).
2013;260(1):166-71.
147. El Hachioui H, Lingsma HF, Van De SandtKoenderman MWME, Dippel DWJ, Koudstaal PJ,
2013;54(1 SUPPL.1):47-53.
141. Eggers KM, Armstrong PW, Califf RM, Johnston
Visch-Brink EG. Long-Term Prognosis of Aphasia
N, Simoons ML, Venge P, James SK. Clinical and
after Stroke. J Neurol Neurosurg Psychiatry.
122
T, Isaacs A, Isomaa B, Karssen LC, Kettunen J,
2012;84(3):310-5.
148. Ertaş G, Van Beusekom H. Drug Eluting Stents:
Koenig W, Kuulasmaa K, Laatikainen T, Laitinen
Current Status and New Developments. İlaç
J, Lindgren C, Lyssenko V, Laara E, Rayner NW,
kapli{dotless} stentler: Mevcut durum ve yeni
Mannisto S, Pouta A, Rathmann W, Rivadeneira
gelişmeler. Anadolu Kardiyol Derg 2012;12(8):676-83.
F, Ruokonen A, Savolainen MJ, Sijbrands EJ,
149. Evans DM, Brion MJ, Paternoster L, Kemp JP,
Small KS, Smit JH, Steinthorsdottir V, Syvanen
McMahon G, Munafo M, Whitfield JB, Medland
AC, Taanila A, Tobin MD, Uitterlinden AG, Willems
SE, Montgomery GW, Consortium G, Consortium
SM, Willemsen G, Witteman J, Perola M, Evans A,
CRP, Consortium TAG, Timpson NJ, St Pourcain B,
Ferrieres J, Virtamo J, Kee F, Tregouet DA, Arveiler
Lawlor DA, Martin NG, Dehghan A, Hirschhorn J,
D, Amouyel P, Ferrario MM, Brambilla P, Hall AS,
Davey Smith G. Mining the Human Phenome Using
Heath AC, Madden PA, Martin NG, Montgomery
Allelic Scores That Index Biological Intermediates.
GW, Whitfield JB, Jula A, Knekt P, Oostra B, van
PLoS Genet. 2013;9(10):e1003919.
Duijn CM, Penninx BW, Davey Smith G, Kaprio J,
150. Ezzahti M, Sijbrands EJG, Mulder MT, van Lennep
Samani NJ, Gieger C, Peters A, Wichmann HE,
JER. Familial Hypercholesterolaemia: New
Boomsma DI, de Geus EJ, Tuomi T, Power C,
Treatment Options. Neth J Med. J. 2013;71(5):227-
Hammond CJ, Spector TD, Lind L, Orho-Melander
33.
M, Palmer CN, Morris AD, Groop L, Jarvelin
151. Faez T, Emmer M, Kooiman K, Versluis M, Van
MR, Salomaa V, Vartiainen E, Hofman A, Ripatti
Der Steen A, De Jong N. 20 Years of Ultrasound
S, Metspalu A, Thorsteinsdottir U, Stefansson
Contrast Agent Modeling. IEEE Transactions on
K, Pedersen NL, McCarthy MI, Ingelsson E,
Ultrasonics, Ferroelectrics, and Frequency Control.
Prokopenko I, European Network for Genetic
2013;60(1):7-20.
and Genomic Epidemiology engage consortium.
152. Fall T, Hagg S, Magi R, Ploner A, Fischer K,
The Role of Adiposity in Cardiometabolic Traits:
Horikoshi M, Sarin AP, Thorleifsson G, Ladenvall
A Mendelian Randomization Analysis. PLoS Med.
C, Kals M, Kuningas M, Draisma HH, Ried JS, van
2013;10(6):e1001474.
Zuydam NR, Huikari V, Mangino M, Sonestedt E,
153. Farooq V, Girasis C, Magro M, Onuma Y, Morel
Benyamin B, Nelson CP, Rivera NV, Kristiansson
MA, Heo JH, Garcia-Garcia H, Kappetein AP, Van
K, Shen HY, Havulinna AS, Dehghan A, Donnelly
Den Brand M, Holmes DR, Mack M, Feldman T,
LA, Kaakinen M, Nuotio ML, Robertson N, de
Colombo A, Ståhle E, James S, Carrié D, Fournial
Bruijn RF, Ikram MA, Amin N, Balmforth AJ, Braund
G, Van Es GA, Dawkins KD, Mohr FW, Morice
PS, Doney AS, Doring A, Elliott P, Esko T, Franco
MC, Serruys PW. The Cabg Syntax Score - an
OH, Gretarsdottir S, Hartikainen AL, Heikkila K,
Angiographic Tool to Grade the Complexity of
Herzig KH, Holm H, Hottenga JJ, Hypponen E, Illig
Coronary Disease Following Coronary Artery
123
Bypass Graft Surgery: From the Syntax Left
(Syntax) Trial Validation of the Residual Syntax
Main Angiographic (Syntax-Le Mans) Substudy.
Score. Circulation. 2013;128(2):141-51.
159. Farooq V, Serruys PW, Garcia-Garcia HM, Zhang
154. Farooq V, Gogas BD, Okamura T, Heo JH, Magro
Y, Bourantas CV, Holmes DR, MacK M, Feldman
M, Gomez-Lara J, Onuma Y, Radu MD, Brugaletta
T, Morice MC, Ståhle E, James S, Colombo A,
S, Van Bochove G, Van Geuns RJ, Garcìa-Garcìa
Diletti R, Papafaklis MI, De Vries T, Morel MA,
HM, Serruys PW. Three-Dimensional Optical
Van Es GA, Mohr FW, Dawkins KD, Kappetein
Frequency Domain Imaging in Conventional
AP, Sianos G, Boersma E. The Negative Impact
Percutaneous Coronary Intervention: The
of Incomplete Angiographic Revascularization
Potential for Clinical Application. Eur Heart J.
on Clinical Outcomes and Its Association with
2013;34(12):875-85.
Total Occlusions: The Syntax (Synergy between
155. Farooq V, Serruys PW. “Cherry-Picking” Patients
Percutaneous Coronary Intervention with Taxus
for Randomized, Controlled Trials - Reliving the
and Cardiac Surgery) Trial. J Am Coll Cardiol.
Past. J Am Coll Cardiol. 2013;61(24):2492.
2013;61(3):282-94.
156. Farooq V, Serruys PW. Complex Coronary Artery
160. Farooq V, Serruys PW, Heo JH, Gogas BD,
Disease: Would Outcomes from the Syntax
Onuma Y, Perkins LE, Diletti R, Radu MD, Räber
(Synergy between Percutaneous Coronary
L, Bourantas CV, Zhang Y, Van Remortel E, Pawar
Intervention with Taxus and Cardiac Surgery) Trial
R, Rapoza RJ, Powers JC, Van Beusekom HMM,
Have Differed with Newer-Generation Drug-Eluting
Garcìa-Garcìa HM, Virmani R. Intracoronary
Stents? JACC: Cardiovascular Interventions.
Optical Coherence Tomography and Histology of
2013;6(10):1023-5.
Overlapping Everolimus-Eluting Bioresorbable
157. Farooq V, Serruys PW. Observations from the
Vascular Scaffolds in a Porcine Coronary Artery
Credo-Kyoto Three-Vessel Disease Registry: Can
Model: The Potential Implications for Clinical
One Adjust for the Unadjustable? EuroIntervention.
Practice. JACC: Cardiovascular Interventions.
2013;9(4):419-21.
2013;6(5):523-32.
158. Farooq V, Serruys PW, Bourantas CV, Zhang Y,
161. Farooq V, Serruys PW, Vranckx P, Bourantas CV,
Muramatsu T, Feldman T, Holmes DR, Mack M,
Girasis C, Holmes DR, Kappetein AP, Mack M,
Morice MC, Ståhle E, Colombo A, De Vries T,
Feldman T, Morice MC, Colombo A, Morel MA,
Morel MA, Dawkins KD, Kappetein AP, Mohr FW.
De Vries T, Dawkins KD, Mohr FW, James S,
Quantification of Incomplete Revascularization
Ståhle E. Incidence, Correlates, and Significance
and Its Association with Five-Year Mortality in
of Abnormal Cardiac Enzyme Rises in Patients
the Synergy between Percutaneous Coronary
Treated with Surgical or Percutaneous Based
Intervention with Taxus and Cardiac Surgery
Revascularisation: A Substudy from the Synergy
124
between Percutaneous Coronary Interventions with
Syntax (Synergy between Percutaneous Coronary
Taxus and Cardiac Surgery (Syntax) Trial. Int J
Interventions with Taxus and Cardiac Surgery)
Cardiol. 2013;168(6):5287-92.
Score. JACC: Cardiovascular Interventions.
162. Farooq V, Serruys PW, Zhang Y, Mack M, Ståhle
2013;6(7):737-45.
E, Holmes DR, Feldman T, Morice MC, Colombo
166. Farooq V, Vranckx P, Mauri L, Cutlip DE, Belardi
A, Bourantas CV, De Vries T, Morel MA, Dawkins
J, Silber S, Widimsky P, Leon M, Windecker S,
KD, Kappetein AP, Mohr FW. Short-Term and Long-
Meredith I, Negoita M, van Leeuwen F, Neumann
Term Clinical Impact of Stent Thrombosis and Graft
FJ, Yeung AC, Garcia-Garcia HM, Serruys PW.
Occlusion in the Syntax Trial at 5 Years: Synergy
Impact of Overlapping Newer Generation Drug-
between Percutaneous Coronary Intervention with
Eluting Stents on Clinical and Angiographic
Taxus and Cardiac Surgery Trial. J Am Coll Cardiol.
Outcomes: Pooled Analysis of Five Trials from
2013;62(25):2360-9.
the International Global Resolute Program. Heart.
163. Farooq V, Van Klaveren D, Steyerberg EW, Meliga
2013;99(9):626-33.
E, Vergouwe Y, Chieffo A, Kappetein AP, Colombo
167. Fennis TFM, Compter A, Van Den Broek MWC,
A, Holmes Jr DR, MacK M, Feldman T, Morice MC,
Koudstaal PJ, Algra A, Koehler PJ. Is Isolated
Ståhle E, Onuma Y, Morel MA, Garcia-Garcia HM,
Aphasia a Typical Presentation of Presumed
Van Es GA, Dawkins KD, Mohr FW, Serruys PW.
Cardioembolic Transient Ischemic Attack or
Anatomical and Clinical Characteristics to Guide
Stroke? Cerebrovasc Dis. 2013;35(4):337-40.
Decision Making between Coronary Artery Bypass
168. Ferrari R, Boersma E. The Impact of Ace Inhibition
Surgery and Percutaneous Coronary Intervention
on All-Cause and Cardiovascular Mortality in
for Individual Patients: Development and Validation
Contemporary Hypertension Trials: A Review.
of Syntax Score Ii. Lancet. 2013;381(9867):639-50.
Expert Rev Cardiovasc Ther. 2013;11(6):705-17.
164. Farooq V, Van Klaveren D, Steyerberg EW, Serruys
169. Firouzian A, Manniesing R, Metz CT, Risselada R,
PW. Authors’ Reply. Lancet. 2013;381(9881):1899-
Klein S, van Kooten F, Sturkenboom MCJM, van der
900.
Lugt A, Niessen WJ. Quantification of Intracranial
165. Farooq V, Vergouwe Y, Généreux P, Bourantas
Aneurysm Morphodynamics from Ecg-Gated Ct
CV, Palmerini T, Caixeta A, Garcìa-Garcìa HM,
Angiography. Acad Radiol. 2013;20(1):52-8.
Diletti R, Morel MA, McAndrew TC, Kappetein
170. Flamee P, C DEA, Bhutia JT, Conte G, Beckers S,
AP, Valgimigli M, Windecker S, Dawkins KD,
Umbrain V, Verborgh C, Chierchia GB, S VANM,
Steyerberg EW, Serruys PW, Stone GW. Prediction
Casado-Arroyo R, Sarkozy A, Brugada P, Poelaert
of 1-Year Mortality in Patients with Acute Coronary
J. Safe Single-Dose Administration of Propofol
Syndromes Undergoing Percutaneous Coronary
in Patients with Established Brugada Syndrome:
Intervention: Validation of the Logistic Clinical
A Retrospective Database Analysis. Pacing Clin
125
TW, Mollet NRA, De Feyter PJ, Fleischmann
Electrophysiol. 2013;36(12):1516-21.
171. Fonville S, Zandbergen AAM, Vermeer SE, Dippel
KE, Nieman K, Myriam Hunink MG. Coronary
DWJ, Koudstaal PJ, Den Hertog HM. Prevalence
Computed Tomography Versus Exercise Testing
of Prediabetes and Newly Diagnosed Diabetes in
in Patients with Stable Chest Pain: Comparative
Patients with a Transient Ischemic Attack or Stroke.
Effectiveness and Costs. Int J Cardiol.
Cerebrovasc Dis. 2013;36(4):283-9.
2013;167(4):1268-75.
172. Fortrie G, Stads S, de Geus HRH, Groeneveld
179. Généreux P, Head SJ, Hahn R, Daneault B,
ABJ, Zietse R, Betjes MGH. Determinants of Renal
Kodali S, Williams MR, van Mieghem NM, Alu MC,
Function at Hospital Discharge of Patients Treated
Serruys PW, Kappetein AP, Leon MB. Paravalvular
with Renal Replacement Therapy in the Intensive
Leak after Transcatheter Aortic Valve Replacement:
Care Unit. J Crit Care. 2013;28(2):126-32.
The New Achilles’ Heel? A Comprehensive
173. Fortunati V, Verhaart RF, van der Lijn F, Niessen
Review of the Literature. J Am Coll Cardiol.
WJ, Veenland JF, Paulides MM, van Walsum T.
2013;61(11):1125-36.
Tissue Segmentation of Head and Neck Ct Images
180. Gensicke H, Zumbrunn T, Jongen LM,
for Treatment Planning: A Multiatlas Approach
Nederkoorn PJ, MacDonald S, Gaines PA, Lyrer
Combined with Intensity Modeling. Med Phys.
PA, Wetzel SG, Van Der Lugt A, Mali WPTM,
2013;40(7):071905.
Brown MM, Van Der Worp HB, Engelter ST,
174. García-García HM, Schultz C, Duckers E, Regar E,
Bonati LH. Characteristics of Ischemic Brain
Ligthart J, Serruys PW, Van Geuns RJ. Five-Year
Lesions after Stenting or Endarterectomy for
Follow-up of the Absorb Bioresorbable Everolimus-
Symptomatic Carotid Artery Stenosis: Results
Eluting Vascular Scaffold System: Multimodality
from the International Carotid Stenting Study-
Imaging Assessment. EuroIntervention.
Magnetic Resonance Imaging Substudy. Stroke.
2013;8(10):1226-7.
2013;44(1):80-6.
175. Garg S, Bourantas C, Serruys PW. New Concepts
181. Gijsen F, van der Giessen A, van der Steen
in the Design of Drug-Eluting Coronary Stents.
A, Wentzel J. Shear Stress and Advanced
Nature Reviews Cardiology. 2013;10(5):248-60.
Atherosclerosis in Human Coronary Arteries. J
176. Garg S, Bourantas C, Serruys PW. Des the Year
in Review: Controversies. Minerva Cardioangiol.
Biomech. 2013;46(2):240-7.
182. Girasis C, Farooq V, Diletti R, Muramatsu T,
Bourantas CV, Onuma Y, Holmes DR, Feldman
2013;61(2):99-123.
177. Garg S, Serruys PW. An Update on Drug-
TE, Morel MA, Van Es GA, Dawkins KD, Morice
Eluting Stents. Current Treatment Options in
MC, Serruys PW. Impact of 3-Dimensional
Cardiovascular Medicine. 2013;15(1):61-78.
Bifurcation Angle on 5-Year Outcome of Patients
178. Genders TSS, Ferket BS, Dedic A, Galema
after Percutaneous Coronary Intervention for Left
126
Main Coronary Artery Disease: A Substudy of the
DS, Giddens DP, Serruys PW, Samady H.
Syntax Trial (Synergy between Percutaneous
Biomechanical Assessment of Fully Bioresorbable
Coronary Intervention with Taxus and Cardiac
Devices. JACC: Cardiovascular Interventions.
Surgery). JACC: Cardiovascular Interventions.
2013;6(12):1250-60.
2013;6(7):760-1.
187. Gogas BD, Muramatsu T, Garcia-Garcia HM,
183. Girasis C, Schuurbiers JCH, Muramatsu T, Aben
Bourantas CV, Holm NR, Thuesen L, Farooq V,
JP, Onuma Y, Soekhradj S, Morel MA, Van Geuns
Onuma Y, Serruys PW. In Vivo Three Dimensional
RJ, Wentzel JJ, Serruys PW. Advanced Three-
Optical Coherence Tomography. A Novel Imaging
Dimensional Quantitative Coronary Angiographic
Modality to Visualize the Edge Vascular Response.
Assessment of Bifurcation Lesions: Methodology
Int J Cardiol. 2013;164(3):e35-e7.
and Phantom Validation. EuroIntervention.
188. Gomez-Lara J, Brugaletta S, Gomez-Hospital JA,
Ferreiro JL, Roura G, Romaguera R, Martin-Yuste
2013;8(12):1451-60.
184. Gogas BD, Bourantas CV, Garcia-Garcia HM,
V, Masotti M, Iñiguez A, Serra A, Hernandez-
Onuma Y, Muramatsu T, Farooq V, Diletti R, Van
Antolin R, Mainar V, Valgimigli M, Tespili M, Den
Geuns RJM, De Bruyne B, Chevalier B, Thuesen
Heijer P, Bethencourt A, Vazquez N, Serruys P,
L, Smits PC, Dudek D, Koolen J, Windecker S,
Sabate M, Cequier A. Everolimus-Eluting Stent
Whitbourn R, McClean D, Dorange C, Miquel-
Versus Bare Metal Stent in Proximal Left Anterior
Hebert K, Veldhof S, Rapoza R, Ormiston JA,
Descending St-Elevation Myocardial Infarction:
Serruys PW. The Edge Vascular Response
Insights from the Examination Trial. Am Heart J.
Following Implantation of the Absorb EverolimusEluting Bioresorbable Vascular Scaffold and the
2013;166(1):119-26.e1.
189. Gonçalves FB, Van De Luijtgaarden KM, Hoeks
Xience V Metallic Everolimus-Eluting Stent. First
SE, Hendriks JM, Raa ST, Rouwet EV, Stolker RJ,
Serial Follow-up Assessment at Six Months and
Verhagen HJM. Adequate Seal and No Endoleak
Two Years: Insights from the First-in-Man Absorb
on the First Postoperative Computed Tomography
Cohort B and Spirit Ii Trials. EuroIntervention.
Angiography as Criteria for No Additional Imaging
2013;9(6):709-20.
up to 5 Years after Endovascular Aneurysm Repair.
185. Gogas BD, Garcia-Garcia HM, Onuma Y,
Muramatsu T, Farooq V, Bourantas CV, Serruys
J Vasc Surg. 2013;57(6):1503-11.
190. Górecsny S, Moszura T, Dryzek P, Sysa-Dedecjus
PW. Edge Vascular Response after Percutaneous
A, Moll JJ, Witsenburg M, Moll JA. Percutaneous
Coronary Intervention. JACC: Cardiovascular
melody valve implantation in a 10-year-old boy with
pulmonary homograft stenosis. Polski Przeglad
186. Gogas BD, King Iii SB, Timmins LH, Passerini
T, Piccinelli M, Veneziani A, Kim S, Molony
Kardiologiczny 2013; 15,2:152-155.
191. Groeneveld AB, Navickis RJ, Wilkes MM. Reply to
127
Letters: “Safety of Colloids: A Knowledge Issue?,”
Ventricular Arrhythmias or Mortality in Patients
“Update on the Comparative Safety of Colloids:
with an Implantable Cardioverter Defibrillator.
Was This Review Really Systematic?,” and “Is It
Psychosom Med. 2013;75(1):36-41.
Already Time to Update the Comparative Safety of
197. Habibović M, Versteeg H, Pelle AJM, Theuns
Colloids?”. Ann Surg. 2013;257(1):e3-4.
DAMJ, Jordaens L, Pedersen SS. Poor Health
192. Guenoun J, Ruggiero A, Doeswijk G, Janssens RC,
Status and Distress in Cardiac Patients: The Role
Koning GA, Kotek G, Krestin GP, Bernsen MR. In
of Device Therapy Vs. Underlying Heart Disease.
Vivo Quantitative Assessment of Cell Viability of
Europace. 2013;15(3):355-61.
Gadolinium or Iron-Labeled Cells Using Mri and
198. Hameeteman K, Rozie S, Metz CT, Manniesing
Bioluminescence Imaging. Contrast Media and
R, van Walsum T, van der Lugt A, Niessen WJ,
Molecular Imaging. 2013;8(2):165-74.
Klein S. Automatic Carotid Artery Distensibility
193. Gutiérrez-Chico JL, Räber L, Regar E, Okamura
Measurements from Cta Using Nonrigid
T, Di Mario C, Van Es GA, Windecker S, Serruys
Registration. Med Image Anal. 2013;17(5):515-24.
PW. Tissue Coverage and Neointimal Hyperplasia
199. Hameeteman K, van ‘t Klooster R, Selwaness
in Overlap Versus Nonoverlap Segments of Drug-
M, van der Lugt A, Witteman JC, Niessen WJ,
Eluting Stents 9 to 13 Months after Implantation:
Klein S. Carotid Wall Volume Quantification
In Vivo Assessment with Optical Coherence
from Magnetic Resonance Images Using
Tomography. Am Heart J. 2013;166(1):83-94.e3.
Deformable Model Fitting and Learning-Based
194. Haak A, Vegas-Sanchez-Ferrero G, Mulder HH,
Correction of Systematic Errors. Phys Med Biol.
Kirisli HA, Baka N, Metz C, Klein S, Ren B, Van
Burken G, Van Der Steen AFW, Pluim JPW,
2013;58(5):1605-23.
200. Harakalova M, Van Der Smagt J, De Kovel CGF,
Van Walsum T, Bosch JG. Segmentation of 3d
Slot RV, Poot M, Nijman IJ, Medic J, Joziasse
Transesophageal Echocardiograms by Multi-Cavity
I, Deckers J, Roos-Hesselink JW, Wessels
Active Shape Model and Gamma Mixture Model.
MW, Baars HF, Weiss MM, Pals G, Golmard L,
LNCS 2013;8090:19-26.
Jeunemaitre X, Lindhout D, Cuppen E, Baas
195. Habib SM, Hagen SM, Korte MR, Zietse R, Dor
AF. Incomplete Segregation of Myh11 Variants
FJMF, Betjes MGH. Localized Encapsulating
with Thoracic Aortic Aneurysms and Dissections
Peritoneal Sclerosis Constricting the Terminal
and Patent Ductus Arteriosus. Eur J Hum Genet.
Ileum-an Unusual Appearance Requiring Surgical
Intervention. Perit Dial Int. 2013;33(5):503-6.
2013;21(5):487-93.
201. He C, Von Segesser LK, Kappetein PA, Mestres
196. Habibović M, Pedersen SS, Van Den Broek
CA, Smith JA, Choong CKC. Acute Pulmonary
KC, Theuns DAMJ, Jordaens L, Van Der Voort
Embolectomy. Eur J Cardiothorac Surg.
PH, Alings M, Denollet J. Anxiety and Risk of
2013;43(6):1087-95.
128
202. Head SJ, Börgermann J, Osnabrugge RLJ, Kieser
Term Survival of Young Patients with Coronary
TM, Falk V, Taggart DP, Puskas JD, Gummert
Artery Disease Is Best Realized through Surgical
JF, Kappetein AP. Coronary Artery Bypass
Revascularization with Mammary Arteries. J Am
Grafting: Part 2 - Optimizing Outcomes and Future
Prospects. Eur Heart J. 2013;34(37):2873-86.
Coll Cardiol. 2013;61(22):2312-3.
209. Heinonen I, Savolainen AM, Han C, Kemppainen
203. Head SJ, Howell NJ, Osnabrugge RLJ,
J, Oikonen V, Luotolahti M, Duncker DJ, Merkus
Bridgewater B, Keogh BE, Kinsman R, Walton
D, Knuuti J, Kalliokoski KK. Pulmonary Blood Flow
P, Gummert JF, Pagano D, Kappetein AP. The
and Its Distribution in Highly Trained Endurance
European Association for Cardio-Thoracic
Athletes and Healthy Control Subjects. J Appl
Surgery (Eacts)Database: An Introduction. Eur J
Physiol. 2013;114(3):329-34.
Cardiothorac Surg. 2013;44(3):e175-e80.
210. Helmi M, De Wilde RBP, Jansen JRC, Geerts BF,
204. Head SJ, Kaul S, Mack MJ, Serruys PW, Taggart
Versteegh MIM, Van Den Berg PCM, Gommers D,
DP, Holmes DR, Leon MB, Marco J, Bogers
Groeneveld ABJ. Comparing Hemodynamic Effects
AJJC, Kappetein AP. The Rationale for Heart
with Three Different Measurement Devices, of Two
Team Decision-Making for Patients with Stable,
Methods of External Leg Compression Versus
Complex Coronary Artery Disease. Eur Heart J.
Passive Leg Raising in Patients after Cardiac
2013;34(32):2510-8b.
Surgery. J Clin Monit Comput. 2013;27(2):163-70.
205. Head SJ, Kaul S, Tijssen JGP, Serruys PW,
211. Helmi M, Lima A, Gommers D, Bakker J, Van
Kappetein AP. Subgroup Analyses in Trial Reports
Bommel J. Inflatable External Upper and Lower
Comparing Percutaneous Coronary Intervention
Leg Compression Improves Stroke Volume and
with Coronary Artery Bypass Surgery. JAMA
Peripheral Perfusion During Central Hypovolemia
2013;310(19):2097-8.
in Healthy Volunteers. Future Cardiology.
206. Head SJ, Kieser TM, Falk V, Huysmans HA,
Kappetein AP. Coronary Artery Bypass Grafting:
2013;9(5):649-55.
212. Helmi M, Lima A, Gommers D, Van Bommel J,
Part 1 - the Evolution over the First 50 Years. Eur
Bakker J. Inflatable External Leg Compression
Heart J. 2013;34(37):2862-72.
Prevents Orthostatic Hypotension in a Patient with
207. Head SJ, Osnabrugge RLJ, Howell NJ, Freemantle
a Traumatic Cervical Spinal Cord Injury. Future
N, Bridgewater B, Pagano D, Pieter Kappetein
A. A Systematic Review of Risk Prediction in
Cardiology. 2013;9(5):645-8.
213. Heo JH, Brugaletta S, Garcia-Garcia HM, Gomez-
Adult Cardiac Surgery: Considerations for Future
Lara J, Ligthart JM, Witberg K, Magro M, Shin
Model Development. Eur J Cardiothorac Surg.
ES, Serruys PW. Reproducibility of Intravascular
2013;43(5):e121-e9.
Ultrasound Imap for Radiofrequency Data Analysis:
208. Head SJ, Osnabrugge RLJ, Kappetein AP. Long-
Implications for Design of Longitudinal Studies
129
Reproducibility of Intravascular Ultrasound Imap.
220. Hoogwegt MT, Kupper N, Jordaens L, Pedersen
Catheter Cardiovasc Interv. 2013.doi:10.1002/
SS, Theuns DAMJ. Comorbidity Burden Is
ccd.23335
Associated with Poor Psychological Well-Being
214. Heuvelman HJ, Arabkhani B, Cornette JMJ,
and Physical Health Status in Patients with an
Pieper PG, Bogers AJJC, Takkenberg JJM, Roos-
Implantable Cardioverter- Defibrillator. Europace.
Hesselink JW. Pregnancy Outcomes in Women
2013;15(10):1469-74.
with Aortic Valve Substitutes. Am J Cardiol.
221. Hoogwegt MT, Theuns DAMJ, Kupper N, Jordaens
L, Pedersen SS. Relation of Statin Therapy to
2013;111(3):382-7.
215. Heuvelman HJ, van Geldorp MWA, Kappetein
Psychological Functioning in Patients with an
AP, Geleijnse ML, Galema TW, Bogers AJJC,
Implantable Cardioverter Defibrillator. Am J
Takkenberg JJM. Clinical Course of Patients
Cardiol. 2013;111(8):1169-74.
Diagnosed with Severe Aortic Stenosis in the
222. Hoorn EJ, Tuut MK, Hoorntje SJ, van Saase
Rotterdam Area: Insights from the Avarijn Study.
JLMC, Zietse R, Geers AB. Dutch Guideline for
the Management of Electrolyte Disorders - 2012
216. Hickey GL, Grant SW, Cosgriff R, Dimarakis I,
Revision. Neth J Med. 2013;71(3):153-65.
Pagano D, Kappetein AP, Bridgewater B. Clinical
223. Hoorn EJ, Zietse R. Disorders of Calcium and
Registries: Governance, Management, Analysis
Magnesium Balance: A Physiology-Based
and Applications. Eur J Cardiothorac Surg.
Approach. Pediatr Nephrol. 2013;28(8):1195-206.
224. Hoorn EJ, Zietse R. Hyponatremia and Mortality:
2013;44(4):605-14.
217. Hoeboer SH, Groeneveld AB. Changes in
Moving Beyond Associations. Am J Kidney Dis.
Circulating Procalcitonin Versus C-Reactive
2013;62(1):139-49.
Protein in Predicting Evolution of Infectious
225. Horer J, Kasnar-Samprec J, Charitos E, Stierle
Disease in Febrile, Critically Ill Patients. PLoS One.
U, Bogers AJ, Hemmer W, Hetzer R, Hubler M,
2013;8(6):e65564.
Robinson DR, Sievers HH, Lange R. Patient Age
218. Hoeks S, Kardys I, Lenzen M, van Domburg R,
at the Ross Operation in Children Influences Aortic
Boersma E. Tools and Techniques - Statistics:
Root Dimensions and Aortic Regurgitation. World J
Descriptive Statistics. EuroIntervention.
Pediatr Congenit Heart Surg. 2013;4(3):245-52.
2013;9(8):1001-3.
226. Houtgraaf JH, De Jong R, Kazemi K, De Groot D,
219. Hol JW, van Lier F, Valk M, Klimek M, Stolker RJ,
Van Der Spoel TIG, Arslan F, Hoefer I, Pasterkamp
Fekkes D. Effect of Major and Minor Surgery on
G, Itescu S, Zijlstra F, Geleijnse ML, Serruys PW,
Plasma Levels of Arginine, Citrulline, Nitric Oxide
Duckers HJ. Intracoronary Infusion of Allogeneic
Metabolites, and Ornithine in Humans. Ann Surg.
Mesenchymal Precursor Cells Directly after
2013;258(6):1072-8.
Experimental Acute Myocardial Infarction Reduces
130
Infarct Size, Abrogates Adverse Remodeling,
W, Stingl C, Koudstaal PJ, Prins ND, Sillevis
and Improves Cardiac Function. Circ Res.
Smitt PAE, Luider TM. Serum Proteomics in
2013;113(2):153-66.
Amnestic Mild Cognitive Impairment. Proteomics.
227. Houtgraaf JH, de Jong R, Monkhorst K, Tempel
2013;13(16):2526-33.
D, van de Kamp E, den Dekker WK, Kazemi K,
233. Ikram MK, De Jong FJ, Vernooij MW, Hofman
Hoefer I, Pasterkamp G, Lewis AL, Stratford PW,
A, Niessen WJ, Van Der Lugt A, Klaver CC,
Wallrapp C, Zijlstra F, Duckers HJ. Feasibility of
Ikram MA. Retinal Vascular Calibers Associate
Intracoronary Glp-1 Eluting Cellbead™ Infusion
Differentially with Cerebral Gray Matter and White
in Acute Myocardial Infarction. Cell Transplant.
Matter Atrophy. Alzheimer Dis Assoc Disord.
2013;22(3):535-43.
2013;27(4):351-5.
228. Houthuizen P, De Jaegere P, Prinzen FW. Letter
234. Iqbal J, Gunn J, Serruys PW. Coronary Stents:
by Houthuizen Et Al Regarding Article, “Clinical
Historical Development, Current Status and Future
Impact of Persistent Left Bundle-Branch Block
Directions. Br Med Bull. 2013;106(1):193-211.
after Transcatheter Aortic Valve Implantation
235. Iqbal J, Serruys PW, Taggart DP. Optimal
with Corevalve Revalving System”. Circulation.
Revascularization for Complex Coronary
2013;128(22).
Artery Disease. Nature Reviews Cardiology.
229. Howell NJ, Head SJ, Freemantle N, van der
2013;10(11):635-47.
Meulen TA, Senanayake E, Menon A, Kappetein
236. Jaarsma D, van der Pluijm I, van der Horst
AP, Pagano D. The New Euroscore Ii Does
GTJ, Hoeijmakers JHJ. Cockayne Syndrome
Not Improve Prediction of Mortality in High-
Pathogenesis: Lessons from Mouse Models. Mech
Risk Patients Undergoing Cardiac Surgery: A
Ageing Dev. 2013;134(5-6):180-95.
Collaborative Analysis of Two European Centres.
237. Jacquillet G, Hoorn EJ, Vilasi A, Unwin RJ. Urinary
Vesicles: In Splendid Isolation. Nephrology Dialysis
Eur J Cardiothorac Surg. 2013;44(6):1006-11.
230. Hricak H, Herold CJ, Krestin GP. A Statement
Transplantation. 2013;28(6):1332-5.
About Authorship from Individual Members of
238. Jahja R, Huijbregts SCJ, de Sonneville LMJ,
the International Society for Strategic Studies in
van der Meere JJ, Bosch AM, Hollak CEM,
Radiology. Radiology. 2013;266(1):14-5.
Rubio-Gozalbo ME, Brouwers MCGJ, Hofstede
231. Huisman CM, Zwart JJ, Roos-Hesselink JW,
FC, de Vries MC, Janssen MCH, van der Ploeg
Duvekot JJ, van Roosmalen J. Incidence and
AT, Langendonk JG, van Spronsen FJ. Mental
Predictors of Maternal Cardiovascular Mortality and
Health and Social Functioning in Early Treated
Severe Morbidity in the Netherlands: A Prospective
Phenylketonuria: The Pku-Cobeso Study. Mol
Cohort Study. PLoS One. 2013;8(2):e56494.
Genet Metab. 2013;110(SUPPL.):S57-S61.
232. IJsselstijn L, Papma JM, Dekker LJM, Calame
239. Jamil Z, Tearney G, Bruining N, Sihan K, Van
131
Soest G, Ligthart J, Van Domburg R, Bouma B,
Vahanian A, Alfieri O, Andreotti F, Antunes MJ,
Regar E. Interstudy Reproducibility of the Second
Baron-Esquivias G, Baumgartner H, Borger MA,
Generation, Fourier Domain Optical Coherence
Carrel TP, De Bonis M, Evangelista A, Falk V, Iung
Tomography in Patients with Coronary Artery
B, Lancellotti P, Pierard L, Price S, Schafers HJ,
Disease and Comparison with Intravascular
Schuler G, Stepinska J, Swedberg K, Takkenberg
Ultrasound: A Study Applying Automated Contour
J, Von Oppell UO, Windecker S, Zamorano JL,
Detection. International Journal of Cardiovascular
Zembala M. Guidelines on the Management of
Imaging. 2013;29(1):39-51.
Valvular Heart Disease (Version 2012). Eur Heart
240. Jansen K, Van Der Steen AF, Van Beusekom
HM, Springeling G, Wu M, Mastik F, Van Soest
J. 2012;33(19):2451-96.
245. Juni RP, Duckers HJ, Vanhoutte PM, Virmani R,
G. Automatic Lipid Detection in Human Coronary
Moens AL. Oxidative Stress and Pathological
Atherosclerosis Using Spectroscopic Intravascular
Changes after Coronary Artery Interventions. J Am
Photoacoustic Imaging. IEEE International
Ultrasonics Symposium, IUS; 2012; 2012. p. 32-5.
Coll Cardiol. 2013;61(14):1471-81.
246. Kappers MHW, Van Esch JHM, Sluiter W,
241. Jansen K, Wu M, Van Der Steen AFW, Van Soest
Sleijfer S, Danser AHJ, Van Den Meiracker AH.
G. Lipid Detection in Atherosclerotic Human
Hypertension Induced by the Tyrosine Kinase
Coronaries by Spectroscopic Intravascular
Inhibitor Sunitinib Is Associated with Increased
Photoacoustic Imaging. Optics Express.
Circulating Endothelin-1 Levels. Hypertension.
2013;21(18):21472-84.
2010;56(4):675-81.
242. Jansen PM, Frenkel WJ, Van Den Born BJH, De
247. Kappetein AP. The Bright Future of Cardiothoracic
Bruijne ELE, Deinum J, Kerstens MN, Arnoldus
and Vascular Surgery: The Role of Eacts. Eur J
JHA, Woittiez AJ, Wijbenga JAM, Zietse R, Jan
Danser AH, Van Den Meiracker AH. Determinants
Cardiothorac Surg. 2013;43(1):211-4.
248. Kappetein AP, Head SJ. Cabg or Pci for
of Blood Pressure Reduction by Eplerenone
Revascularisation in Patients with Diabetes? The
in Uncontrolled Hypertension. J Hypertens.
Lancet Diabetes and Endocrinology. 2013;1(4):266-
2013;31(2):404-13.
243. Johnson M, Gatzoulis M, Roos-Hesselink J.
8.
249. Kappetein AP, Head SJ, Généreux P, Piazza
Pregnancy and Heart Disease: Time for a
N, Van Mieghem NM, Blackstone EH, Brott TG,
Randomized Controlled Trial. Int J Cardiol.
Cohen DJ, Cutlip DE, Van Es GA, Hahn RT, Kirtane
2013;168(4):3149-51.
AJ, Krucoff MW, Kodali S, MacK MJ, Mehran R,
244. Joint Task Force on the Management of Valvular
Rodés-Cabau J, Vranckx P, Webb JG, Windecker
Heart Disease of the European Society of C,
S, Serruys PW, Leon MB. Updated Standardized
European Association for Cardio-Thoracic S,
Endpoint Definitions for Transcatheter Aortic Valve
132
Implantation: The Valve Academic Research
and Back-Rotation in Patients with Reverse
Consortium-2 Consensus Document. J Thorac
Septal Curvature Hypertrophic Cardiomyopathy.
Cardiovasc Surg. 2013;145(1):6-23.
European Heart Journal Cardiovascular Imaging.
250. Kappetein AP, Head SJ, Morice M, Banning AP,
Serruys PW, Mohr F, Dawkins KD, Mack MJ.
2013;14(5):435-42.
256. Kharlamov AN, Duckers HJ, Van Beusekom HMM,
Treatment of Complex Coronary Artery Disease in
Smits PC, Perin EC, Serruys PW. Do We Have a
Patients with Diabetes: 5-Year Results Comparing
Future with Transcatheter Adventitial Delivery of
Outcomes of Bypass Surgery and Percutaneous
Stem Cells? Int J Cardiol. 2013;165(2):217-21.
Coronary Intervention in the Syntax Trial. Eur J
257. Kieser TM, Head SJ, Pieter Kappetein A. Arterial
Grafting and Complete Revascularization:
Cardiothorac Surg. 2013;43(5):1006-13.
251. Karanasos A, Regar E, Geeve P, Van Mieghem
Challenge or Compromise? Curr Opin Cardiol.
NM. Bioresorbable Scaffold in Myocardial
Infarction: Has the Time Come? Int J Cardiol.
2013;28(6):646-53.
258. Kikuchi K, Narita T, Pham VT, Iijima J, Hirota K,
Keka IS, Mohiuddin, Okawa K, Hori T, Fukagawa
2013;167(1):e17-e9.
252. Kardys I, Hoeks S, van Domburg R, Lenzen M,
T, Essers J, Kanaar R, Whitby MC, Sugasawa
Boersma E. Tools and Techniques - Statistics:
K, Taniguchi Y, Kitagawa K, Takeda S. Structure-
Analysis of Continuous Data Using the T-Test and
Specific Endonucleases Xpf and Mus81 Play
Anova. EuroIntervention. 2013;9(6):765-7.
Overlapping but Essential Roles in DNA Repair
253. Kaste M, Murayama S, Ford GA, Dippel DWJ,
by Homologous Recombination. Cancer Res.
Walters MR, Tatlisumak T. Safety, Tolerability and
Pharmacokinetics of Mci-186 in Patients with Acute
2013;73(14):4362-71.
259. Kirişli HA, Schaap M, Metz CT, Dharampal AS,
Ischemic Stroke: New Formulation and Dosing
Meijboom WB, Papadopoulou SL, Dedic A,
Regimen. Cerebrovasc Dis. 2013;36(3):196-204.
Nieman K, de Graaf MA, Meijs MFL, Cramer MJ,
254. Kauer F, Van Dalen BM, Michels M, Soliman
Broersen A, Cetin S, Eslami A, Flórez-Valencia L,
OII, Vletter WB, Van Slegtenhorst M, Ten Cate
Lor KL, Matuszewski B, Melki I, Mohr B, Öksüz
FJ, Geleijnse ML. Diastolic Abnormalities in
I, Shahzad R, Wang C, Kitslaar PH, Unal G,
Normal Phenotype Hypertrophic Cardiomyopathy
Katouzian A, Orkisz M, Chen CM, Precioso F,
Gene Carriers: A Study Using Speckle
Najman L, Masood S, Ünay D, van Vliet L, Moreno
Tracking Echocardiography. Echocardiography.
R, Goldenberg R, Vuçini E, Krestin GP, Niessen
2013;30(5):558-63.
WJ, Van Walsum T. Standardized Evaluation
255. Kauer F, Van Dalen BM, Soliman OII, Van Der
Framework for Evaluating Coronary Artery Stenosis
Zwaan HB, Vletter WB, Schinkel AFL, Ten Cate FJ,
Detection, Stenosis Quantification and Lumen
Geleijnse ML. Regional Left Ventricular Rotation
Segmentation Algorithms in Computed Tomography
133
Angiography. Med Image Anal. 2013;17(8):859-76.
Cognitive Impairment, Brain Structure and Risk of
260. Klijn E, Hulscher HC, Balvers RK, Holland WPJ,
Dementia. Crit Rev Oncol Hematol. 2013;88(1):87-
Bakker J, Vincent AJPE, Dirven CMF, Ince C.
Laser Speckle Imaging Identification of Increases
101.
266. Korbee RS, Boiten HJ, Ottenhof M, Valkema R,
in Cortical Microcirculatory Blood Flow Induced by
Van Domburg RT, Schinkel AFL. What Is the Value
Motor Activity During Awake Craniotomy ; Clinical
of Stress 99mtc-Tetrofosmin Myocardial Perfusion
Article. J Neurosurg. 2013;118(2):280-6.
Imaging for the Assessment of Very Long-Term
261. Kokhuis TJA, Garbin V, Kooiman K, Naaijkens BA,
Outcome in Obese Patients? J Nucl Cardiol.
Juffermans LJM, Kamp O, van der Steen AFW,
Versluis M, de Jong N. Secondary Bjerknes Forces
2013;20(2):227-33.
267. Krestin G. Interview: Adapting to the Changing
Deform Targeted Microbubbles. Ultrasound Med
Field of Imaging. Imaging in Medicine.
Biol. 2013;39(3):490-506.
2013;5(4):315-8.
262. Koning L, Pas SD, De Man RA, Balk AHMM, De
268. Krop M, Lu X, Danser AHJ, Meima ME. The (Pro)
Knegt RJ, Ten Kate FJ, Osterhaus ADME, Van Der
Renin Receptor. A Decade of Research: What
Eijk AA. Clinical Implications of Chronic Hepatitis
Have We Learned? Pflugers Archiv European
E Virus Infection in Heart Transplant Recipients. J
Journal of Physiology. 2013;465(1):87-97.
Heart Lung Transplant. 2013;32(1):78-85.
269. Krop M, Lu X, Verdonk K, Schalekamp MADH,
263. Konrad FM, Mik EG, Bodmer SIA, Ates NB,
Van Gool JMG, McKeever BM, Gregg R, Danser
Willems HFEM, Klingel K, De Geus HRH,
AHJ. New Renin Inhibitor Vtp-27999 Alters Renin
Stolker RJ, Johannes T. Acute Normovolemic
Immunoreactivity and Does Not Unfold Prorenin.
Hemodilution in the Pig Is Associated with
Hypertension. 2013;61(5):1075-82.
Renal Tissue Edema, Impaired Renal
270. Kuiper AN, Trof RJ, Groeneveld ABJ. Mixed
Microvascular Oxygenation, and Functional Loss.
Venous O2 Saturation and Fluid Responsiveness
Anesthesiology. 2013;119(2):256-69.
after Cardiac or Major Vascular Surgery. Journal of
264. Kooiman K, Van Der Steen AFW, De Jong N. Role
of Intracellular Calcium and Reactive Oxygen
Cardiothoracic Surgery. 2013;8(1).189
271. Kurata A, Dharampal A, Dedic A, De Feyter PJ,
Species in Microbubble-Mediated Alterations of
Krestin GP, Dijkshoorn ML, Nieman K. Impact of
Endothelial Layer Permeability. IEEE Transactions
Iterative Reconstruction on Ct Coronary Calcium
Quantification. Eur Radiol. 2013;23(12):3246-52.
on Ultrasonics, Ferroelectrics, and Frequency
Control. 2013;60(9):1811-5.
272. Kusadasi N, Groeneveld ABJ. A Perspective on
265. Koppelmans V, Breteler MM, Boogerd W,
Mesenchymal Stromal Cell Transplantation in the
Seynaeve C, Schagen SB. Late Effects of Adjuvant
Chemotherapy for Adult Onset Non-Cns Cancer;
Treatment of Sepsis. Shock. 2013;40(5):352-7.
273. Kuster DWD, Mulders J, ten Cate FJ, Michels M,
134
dos Remedios CG, da Costa Martins PA, van der
L, Graff C, Delepine M, Ferri R, Reynolds CA,
Velden J, Oudejans CBM. Microrna Transcriptome
Lannfelt L, Ingelsson M, Prince JA, Chillotti C,
Profiling in Cardiac Tissue of Hypertrophic
Pilotto A, Seripa D, Boland A, Mancuso M, Bossù
Cardiomyopathy Patients with Mybpc3 Mutations. J
P, Annoni G, Nacmias B, Bosco P, Panza F,
Mol Cell Cardiol. 2013;65:59-66.
Sanchez-Garcia F, Del Zompo M, Coto E, Owen
274. Labruijere S, Compeer MG, van den Bogaerdt
M, O’Donovan M, Valdivieso F, Caffara P, Scarpini
AJ, van den Brink AM, De Mey JG, Danser AH,
E, Combarros O, Buée L, Campion D, Soininen H,
Batenburg WW. Long-Lasting Physiological
Breteler M, Riemenschneider M, Van Broeckhoven
Antagonism of Calcitonin Gene-Related Peptide
C, Alpérovitch A, Lathrop M, Trégouët DA, Williams
Towards Endothelin-1 in Rat Mesenteric Arteries
J, Amouyel P. Genome-Wide Haplotype Association
and Human Coronary Arteries. Eur J Pharmacol.
Study Identifies the Frmd4a Gene as a Risk
2013;720(1-3):303-9.
Locus for Alzheimer’s Disease. Mol Psychiatry.
275. Labruijere S, van Houten ELAF, de Vries R,
2013;18(4):461-70.
Musterd-Bagghoe UM, Garrelds IM, Kramer
278. Lange S, Fraune C, Alenina N, Bader M, Danser
P, Danser AHJ, Villalón CM, Visser JA,
AHJ, Frenay AR, Van Goor H, Stahl R, Nguyen G,
MaassenVanDenBrink A. Analysis of the Vascular
Schwedhelm E, Wenzel UO. Aliskiren Accumulation
Responses in a Murine Model of Polycystic Ovary
in the Kidney: No Major Role for Binding to Renin
Syndrome. J Endocrinol. 2013;218(2):205-13.
or Prorenin. J Hypertens. 2013;31(4):713-9.
276. Lahousse L, Van Den Bouwhuijsen QJA, Loth DW,
279. Langeslag SJE, Schmidt M, Ghassabian A, Jaddoe
Joos GF, Hofman A, Witteman JCM, Van Der Lugt
VW, Hofman A, van der Lugt A, Verhulst FC,
A, Brusselle GG, Stricker BH. Chronic Obstructive
Tiemeier H, White TJH. Functional Connectivity
Pulmonary Disease and Lipid Core Carotid Artery
between Parietal and Frontal Brain Regions and
Plaques in the Elderly: The Rotterdam Study. Am J
Intelligence in Young Children: The Generation R
Study. Hum Brain Mapp. 2013;34(12):3299-307.
Respir Crit Care Med. 2013;187(1):58-64.
277. Lambert JC, Grenier-Boley B, Harold D, Zelenika
280. Lankhorst S, Kappers MHW, Van Esch JHM,
D, Chouraki V, Kamatani Y, Sleegers K, Ikram MA,
Danser AHJ, Van Den Meiracker AH. Mechanism of
Hiltunen M, Reitz C, Mateo I, Feulner T, Bullido M,
Hypertension and Proteinuria During Angiogenesis
Galimberti D, Concari L, Alvarez V, Sims R, Gerrish
Inhibition: Evolving Role of Endothelin-1. J
A, Chapman J, Deniz-Naranjo C, Solfrizzi V, Sorbi
S, Arosio B, Spalletta G, Siciliano G, Epelbaum
Hypertens. 2013;31(3):444-54.
281. Lee IS, Bourantas CV, Muramatsu T, Gogas BD,
J, Hannequin D, Dartigues JF, Tzourio C, Berr
Heo JH, Diletti R, Farooq V, Zhang Y, Onuma Y,
C, Schrijvers EMC, Rogers R, Tosto G, Pasquier
Serruys PW, Garcia-Garcia HM. Assessment of
F, Bettens K, Van Cauwenberghe C, Fratiglioni
Plaque Evolution in Coronary Bifurcations Located
135
Beyond Everolimus Eluting Scaffolds: Serial
Stricker BH, Hoorn EJ. Electrolyte Disorders in
Intravascular Ultrasound Virtual Histology Study.
Community Subjects: Prevalence and Risk Factors.
Cardiovasc Ultrasound. 2013;11:25.
Am J Med. 2013;126(3):256-63.
282. Lee MJ, Krestin GP, Tali ET. Letter by Lee Et Al
288. Lingsma H, Nauta S, Van Leeuwen N, Borsboom
Regarding Article, “Training of Future Interventional
G, Bruining N, Steyerberg E. Tools & Techniques:
Neuroradiologists: The European Approach”.
Analysis of Clustered Data in Interventional
Stroke. 2013;44(5):e46.
Cardiology: Current Practice and Methodological
283. Leening MJ, Deckers JW, Stricker BH. Screening
Advice. EuroIntervention. 2013;9(1):162-4.
for Heart Failure in the Elderly and the Competition
289. Loeve M, Krestin GP, Rosenfeld M, De Bruijne
of Co-Morbidity. What If We Could Prevent Heart
M, Stick SM, Tiddens HA. Chest Computed
Failure from Reaching the Finish Line First?
Tomography: A Validated Surrogate Endpoint
European Journal of Heart Failure. 2013;15(4):477.
of Cystic Fibrosis Lung Disease? Eur Respir J.
284. Leening MJG, Kavousi M, Steyerberg EW, Hofman
A, De Maat MPM, Oudkerk M, Van Der Lugt A, Van
2013;42(3):844-57.
290. Loland KH, Bleie O, Strand E, Ueland PM,
Den Meiracker AH, Witteman JCM. Evaluation of
Nordrehaug JE, Garcia-Garcia HM, Serruys PW,
Newer Risk Markers for Coronary Heart Disease:
Nygard O. Effect of Folic Acid Supplementation on
The Rotterdam Study. Evaluatie van nieuwe
Levels of Circulating Monocyte Chemoattractant
risicomarkers voor coronaire hartziekte: Erasmus
Protein-1 and the Presence of Intravascular
Rotterdam Gezondheid Onderzoek (ERGO).
Ultrasound Derived Virtual Histology Thin-Cap
Ned Tijdschrift Geneesk 2013;157 A6123
Fibroatheromas in Patients with Stable Angina
285. Lemos PA, Farooq V, Takimura CK, Gutierrez PS,
Virmani R, Kolodgie F, Christians U, Kharlamov A,
Pectoris. PLoS One. 2013;8(7):e70101.
291. Lönnroos E, Kyyrönen P, Bell JS, Van Der
Doshi M, Sojitra P, Van Beusekom HMM, Serruys
Cammen TJM, Hartikainen S. Risk of Death among
PW. Emerging Technologies: Polymer-Free
Persons with Alzheimer’s Disease: A National
Phospholipid Encapsulated Sirolimus Nanocarriers
Register-Based Nested Case-Control Study.
for the Controlled Release of Drug from a StentPlus-Balloon or a Stand-Alone Balloon Catheter.
Journal of Alzheimer’s Disease. 2013;33(1):157-64.
292. Lorza AMA, Carvalho DDB, Petersen J, Van Dijk
AC, Van Der Lugt A, Niessen WJ, Klein S, De
286. Lenzen M, Van Domburg R, Hoeks S, Kardys I,
Bruijne M. Carotid Artery Lumen Segmentation in
Boersma E. Tools & Techniques Methodology
3d Free-Hand Ultrasound Images Using Surface
and Statistics: Randomisation in Clinical Trials.
Graph Cuts. LNCS 2013;8150:542-9.
293. Lu X, Garrelds IM, Wagner CA, Danser AHJ,
287. Liamis G, Rodenburg EM, Hofman A, Zietse R,
Meima ME. (Pro)Renin Receptor Is Required
136
for Prorenin-Dependent and-Independent
of Functional Mitral Valve Regurgitation with the
Regulation of Vacuolar H+-Atpase Activity in
Permanent Percutaneous Transvenous Mitral
Mdck.C11 Collecting Duct Cells. American
Annuloplasty System: Results of the Multicenter
Journal of Physiology - Renal Physiology.
International Percutaneous Transvenous Mitral
2013;305(3):F417-F25.
Annuloplasty System to Reduce Mitral Valve
294. Lu X, Roksnoer LCW, Danser AHJ. The Intrarenal
Regurgitation in Patients with Heart Failure Trial.
Renin-Angiotensin System: Does It Exist?
Am Heart J. 2013;165(5):761-9.
Implications from a Recent Study in Renal
299. MacK MJ, Head SJ, Holmes Jr DR, Ståhle E,
Angiotensin-Converting Enzyme Knockout
Feldman TE, Colombo A, Morice MC, Unger F,
Mice. Nephrology Dialysis Transplantation.
Erglis A, Stoler R, Dawkins KD, Serruys PW, Mohr
2013;28(12):2977-82.
FW, Kappetein AP. Analysis of Stroke Occurring
295. Luijnenburg SE, Helbing WA, Moelker A, Kroft LJM,
in the Syntax Trial Comparing Coronary Artery
Groenink M, Roos-Hesselink JW, De Rijke YB,
Bypass Surgery and Percutaneous Coronary
Hazekamp MG, Bogers AJJC, Vliegen HW, Mulder
Intervention in the Treatment of Complex
BJM. 5-Year Serial Follow-up of Clinical Condition
Coronary Artery Disease. JACC: Cardiovascular
and Ventricular Function in Patients after Repair of
Tetralogy of Fallot. Int J Cardiol. 2013;169(6):439-
300. Magro M, Girasis C, Bartorelli AL, Tarantini G,
Russo F, Trabattoni D, D’Amico G, Galli M, Juame
44.
296. Luijnenburg SE, Peters RE, Van Der Geest RJ,
AG, Almeida MDS, Simsek C, Foley D, Sonck
Moelker A, Roos-Hesselink JW, De Rijke YB,
J, Lesiak M, Kayaert P, Serruys PW, Van Geuns
Mulder BJM, Vliegen HW, Helbing WA. Abnormal
RJ. Acute Procedural and Six-Month Clinical
Right Atrial and Right Ventricular Diastolic Function
Outcome in Patients Treated with a Dedicated
Relate to Impaired Clinical Condition in Patients
Bifurcation Stent for Left Main Stem Disease: The
Operated for Tetralogy of Fallot. Int J Cardiol.
Tryton Lm Multicentre Registry. EuroIntervention.
2013;167(3):833-9.
2013;8(11):1259-69.
297. Lüscher TF, De Feyter P, Sabate M, Van Mieghem
301. Magro M, Regar E, Gutiérrez-Chico JL, Garcia-
NM, Mahfoud F, Serruys PW. The European
Garcia H, Simsek C, Schultz C, Zijlstra F, Serruys
Heart Journal and Eurointervention: Information
PW, Van Geuns RJ. Residual Atherothrombotic
and Education in Interventional Cardiology.
Material after Stenting in Acute Myocardial
Infarction - an Optical Coherence Tomographic
298. MacHaalany J, Bilodeau L, Hoffmann R, Sack
S, Sievert H, Kautzner J, Hehrlein C, Serruys P,
Evaluation. Int J Cardiol. 2013;167(3):656-63.
302. Magro M, Springeling T, van Geuns RJ, Zijlstra
Sénéchal M, Douglas P, Bertrand OF. Treatment
F. Myocardial ‘No-Reflow’ Prevention. Current
137
Park SJ, Kim YH, Onuma Y, Capranzano P, Jegere
Vascular Pharmacology. 2013;11(2):263-77.
303. Maino A, Algra A, Koudstaal PJ, Van Zwet EW,
S, Makkar R, Palacios I, Buszman P, Bande M,
Ferrari MD, Wermer MJH. Concomitant Headache
Chakravarty T, Mehran R, Naber C, Scrocca I,
Influences Long-Term Prognosis after Acute
Margey R, Leon M, Moses J, Fajadet J, Lefèvre T,
Cerebral Ischemia of Noncardioembolic Origin.
Morice MC, Erglis A, Tamburino C, Alfieri O, Conte
Stroke. 2013;44(9):2446-50.
MR, Serruys PW, Colombo A. Coronary Artery
304. Maresca D, Renaud G, van Soest G, Li X, Zhou
Bypass Graft Versus Percutaneous Coronary
Q, Shung KK, De Jong N, Van der Steen AFW.
Intervention with Drug-Eluting Stent Implantation
Contrast-Enhanced Intravascular Ultrasound Pulse
for Diabetic Patients with Unprotected Left Main
Sequences for Bandwidth-Limited Transducers.
Coronary Artery Disease: The D-Delta Registry.
Ultrasound Med Biol. 2013;39(4):706-13.
305. Mees B, Robinson D, Verhagen H, Chuen J.
310. Merkus D, Visser M, Houweling B, Zhou Z, Nelson
Non-Aortic Aneurysms: Natural History and
J, Duncker DJ. Phosphodiesterase 5 Inhibition-
Recommendations for Referral and Treatment.
Induced Coronary Vasodilation Is Reduced
Aust Fam Physician. 2013;42(6):370-4.
after Myocardial Infarction. American Journal of
306. Mees B, Voute M, Bastos Gonçalves F, Mota
Physiology - Heart and Circulatory Physiology.
Capitão L, Verhagen H. Intervention for Type Ii
Endoleaks? “Primum Non Nocere”: Appraisal for
2013;304(10):H1370-H81.
311. Messiaen S, Le Bras A, Duquenne C, Barroca V,
the Conservative Management of Low-Pressure
Moison D, Dechamps N, Doussau M, Bauchet
Endoleaks after Endovascular Aneurysm Repair. J
AL, Guerquin MJ, Livera G, Essers J, Kanaar R,
Cardiovasc Surg (Torino). 2013;54(4):477-84.
Habert R, Bernardino-Sgherri J. Rad54 Is Required
307. Mees BME, Bastos Gonçalves F, Koudstaal PJ,
for the Normal Development of Male and Female
Verhagen HJM. Late Neurological Recovery
Germ Cells and Contributes to the Maintainance of
of Paraplegia after Endovascular Repair of an
Their Genome Integrity after Genotoxic Stress. Cell
Infected Thoracic Aortic Aneurysm. J Vasc Surg.
Death Dis. 2013;4:e774.
2013;57(2):521-4.
312. Metz CT, Schaap M, Klein S, Baka N, Neefjes
308. Meijer E, Drenth JPH, De Fijter JW, Peters DM,
LA, Schultz CJ, Niessen WJ, Van Walsum T.
Wetzels JFM, Zietse R, Gansevoort RT. Lanreotide
Registration of 3d+T Coronary Cta and Monoplane
Protects the Kidney Function in Polycystic Kidney
2d+T X-Ray Angiography. IEEE Trans Med
Disease? Beschermt lanreotide de nierfunctie bij
Imaging. 2013;32(5):919-31.
cystenieren? Ned Tijdschrift Geneesk 2013;15:
313. Mijderwijk H, Van Beek S, Klimek M,
Duivenvoorden HJ, Grüne F, Stolker RJ.
A5867
309. Meliga E, De Benedictis M, Chieffo A, Latib A,
Lorazepam Does Not Improve the Quality of
138
Recovery in Day-Case Surgery Patients: A
Echocardiography in Congenital Heart Disease
Randomised Placebo-Controlled Clinical Trial. Eur
J Anaesthesiol. 2013;30(12):743-51.
Patients. Echocardiography. 2013;30(8):961-6.
319. Moltzer E, Ouhlous M, Roos-Hesselink JW,
314. Mikhaylov EN, Bhagwandien R, Janse PA, Theuns
Bogers AJJC, Witsenburg M. Proximal Aortic
DAMJ, Szili-Torok T. Regular Atrial Tachycardias
Stent Migration. Netherlands Heart Journal.
Developing after Cryoballoon Pulmonary
2013;21(11):517-9.
Vein Isolation: Incidence, Characteristics, and
320. Montalescot G, Sechtem U, Achenbach S,
Predictors. Europace. 2013;15(12):1710-7.
Andreotti F, Arden C, Budaj A, Bugiardini R, Crea
315. Mikhaylov EN, Orshanskaya VS, Lebedev AD,
F, Cuisset T, Di Mario C, Ferreira JR, Gersh BJ,
Szili-Torok T, Lebedev DS. Catheter Ablation
Gitt AK, Hulot JS, Marx N, Opie LH, Pfisterer
of Paroxysmal Atrial Fibrillation in Patients with
M, Prescott E, Ruschitzka F, Sabaté M, Senior
Previous Amiodarone-Induced Hyperthyroidism: A
R, Taggart DP, Van Der Wall EE, Vrints CJM,
Case-Control Study. J Cardiovasc Electrophysiol.
Zamorano JL, Baumgartner H, Bax JJ, Bueno H,
2013;24(8):888-93.
Dean V, Deaton C, Erol C, Fagard R, Ferrari R,
316. Mohr FW, Morice MC, Kappetein AP, Feldman TE,
Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh
Ståhle E, Colombo A, MacK MJ, Holmes Jr DR,
P, Lancellotti P, Linhart A, Nihoyannopoulos P,
Morel MA, Van Dyck N, Houle VM, Dawkins KD,
Piepoli MF, Ponikowski P, Sirnes PA, Tamargo
Serruys PW. Coronary Artery Bypass Graft Surgery
JL, Tendera M, Torbicki A, Wijns W, Windecker S,
Versus Percutaneous Coronary Intervention in
Valgimigli M, Claeys MJ, Donner-Banzhoff N, Frank
Patients with Three-Vessel Disease and Left
H, Funck-Brentano C, Gaemperli O, Gonzalez-
Main Coronary Disease: 5-Year Follow-up of the
Juanatey JR, Hamilos M, Husted S, James SK,
Randomised, Clinical Syntax Trial. The Lancet.
Kervinen K, Kristensen SD, Maggioni AP, Romeo
2013;381(9867):629-38.
F, Rydén L, Simoons ML, Steg PG, Timmis A,
317. Mokhles MM, Charitos E, Stierle U, Rajeswaran
Yildirir A. 2013 Esc Guidelines on the Management
J, Blackstone E, Bogers AJC, Takkenberg JM,
of Stable Coronary Artery Disease. Eur Heart J.
Sievers HH. The Fate of Pulmonary Conduits after
2013;34(38):2949-3003.
the Ross Procedure: Longitudinal Analysis of the
321. Muramatsu T, García-García HM, Onuma Y, Zhang
German-Dutch Ross Registry Experience. Heart.
YJ, Bourantas CV, Diletti R, Iqbal J, Radu MD,
2013;99(24):1857-66.
Ozaki Y, Serruys PW. Intimal Flaps Detected by
318. Mokhles P, Van Den Bosch AE, Vletter - McGhie
Optical Frequency Domain Imaging in the Proximal
JS, Van Domburg RT, Ruys TPE, Kauer F,
Segments of Native Coronary Arteries: An Innocent
Geleijnse ML, Roos-Hesselink JW. Feasibility
Bystander? Insights from the Trofi Trial. Circulation
and Observer Reproducibility of Speckle Tracking
Journal. 2013;77(9):2327-33.
139
322. Muramatsu T, Onuma Y, Garcia-Garcia HM,
Leon MB, Moses JW, Fajadet J, Lefevre T, Morice
Farooq V, Bourantas CV, Morel MA, Li X, Veldhof
MC, Erglis A, Tamburino C, Alfieri O, Serruys PW,
S, Bartorelli A, Whitbourn R, Abizaid A, Serruys
Colombo A. Long-Term Clinical Outcomes after
PW, Investigators S-E. Incidence and Short-Term
Percutaneous Coronary Intervention for Ostial/Mid-
Clinical Outcomes of Small Side Branch Occlusion
Shaft Lesions Versus Distal Bifurcation Lesions in
after Implantation of an Everolimus-Eluting
Unprotected Left Main Coronary Artery: The Delta
Bioresorbable Vascular Scaffold: An Interim Report
Registry (Drug-Eluting Stent for Left Main Coronary
of 435 Patients in the Absorb-Extend Single-Arm
Artery Disease): A Multicenter Registry Evaluating
Trial in Comparison with an Everolimus-Eluting
Percutaneous Coronary Intervention Versus
Metallic Stent in the Spirit First and Ii Trials. JACC
Coronary Artery Bypass Grafting for Left Main
Cardiovasc Interv. 2013;6(3):247-57.
Treatment. JACC: Cardiovascular Interventions.
323. Muramatsu T, Onuma Y, Zhang YJ, Bourantas
CV, Kharlamov A, Diletti R, Farooq V, Gogas BD,
2013;6(12):1242-9.
326. Nakatani S, Proniewska K, Pociask E, Paoletti
Garg S, García-García HM, Ozaki Y, Serruys PW.
G, De Winter S, Muramatsu T, Bruining N. How
Progress in Treatment by Percutaneous Coronary
Clinically Effective Is Intravascular Ultrasound in
Intervention: The Stent of the Future. Avances en
Interventional Cardiology? Present and Future
el tratamiento mediante intervención coronaria
Perspectives. Expert Review of Medical Devices.
percutánea: el stent del futuro Rev Esp Cardiol.
2013;66(6):483-96.
2013;10(6):735-49.
327. Nammas W, Ligthart JMR, Karanasos A, Witberg
324. Mylotte D, Osnabrugge RLJ, Windecker S,
KT, Regar E. Optical Coherence Tomography for
Lefèvre T, De Jaegere P, Jeger R, Wenaweser P,
Evaluation of Coronary Stents in Vivo. Expert
Maisano F, Moat N, Søndergaard L, Bosmans J,
Review of Cardiovascular Therapy. 2013;11(5):577-
Teles RC, Martucci G, Manoharan G, Garcia E,
88.
Van Mieghem NM, Kappetein AP, Serruys PW,
328. Nanchen D, Leening MJG, Locatelli I, Cornuz
Lange R, Piazza N. Transcatheter Aortic Valve
J, Kors JA, Heeringa J, Deckers JW, Hofman
Replacement in Europe: Adoption Trends and
A, Franco OH, Stricker BHC, Witteman JCM,
Factors Influencing Device Utilization. J Am Coll
Dehghan A. Resting Heart Rate and the Risk of
Cardiol. 2013;62(3):210-9.
Heart Failure in Healthy Adults the Rotterdam
325. Naganuma T, Chieffo A, Meliga E, Capodanno D,
Park SJ, Onuma Y, Valgimigli M, Jegere S, Makkar
Study. Circulation: Heart Failure. 2013;6(3):403-10.
329. Nauta ST, Deckers JW, Akkerhuis KM, Van
RR, Palacios IF, Costopoulos C, Kim YH, Buszman
Domburg RT. Age-Dependent Care and Long-Term
PP, Chakravarty T, Sheiban I, Mehran R, Naber
(20 Year) Mortality of 14,434 Myocardial Infarction
C, Margey R, Agnihotri A, Marra S, Capranzano P,
Patients: Changes from 1985 to 2008. Int J Cardiol.
140
2013;167(3):693-7.
2013;62(19):1813-4.
330. Nauta ST, Van Domburg RT, Nuis RJ, Akkerhuis
334. Niessen W, Li S, Wang S. Special Issue on Shape
M, Deckers JW. Decline in 20-Year Mortality
Modeling in Medical Image Analysis. Computer
after Myocardial Infarction in Patients with
Vision and Image Understanding. 2013;117(9):965.
Chronic Kidney Disease: Evolution from the
335. Nieuwstadt HA, Akyildiz AC, Speelman L, Virmani
Prethrombolysis to the Percutaneous Coronary
R, van der Lugt A, van der Steen AF, Wentzel JJ,
Intervention Era. Kidney Int. 2013;84(2):353-8.
Gijsen FJ. The Influence of Axial Image Resolution
331. Nazeri I, Abdi S, Mandegar MH, Naemi S,
on Atherosclerotic Plaque Stress Computations. J
Roshanali F, Tehrai M, Shahabi P, Debonnaire
Biomech. 2013;46(4):689-95.
P, van der Kley F, Katsanos S, Delgado V, Van
336. Nikas D, Bourantas CV, Sakellarios AI, Ramos
Mieghem NM. How Should I Treat Acute Left Main
A, Naka KK, Michalis LK, Serruys PW. New
Coronary Obstruction after Transapical Aortic Valve
Developments in Hybrid Optical Coherence
Implantation? EuroIntervention. 2013;9(6):761-4
Tomographic Imaging: Current Status and Potential
332. Neefjes LA, Rossi A, Genders TSS, Nieman K,
Implications in Clinical Practice and Research.
Papadopoulou SL, Dharampal AS, Schultz CJ,
Current Cardiovascular Imaging Reports.
Weustink AC, Dijkshoorn ML, Ten Kate GJR,
2013;6(5):411-20.
Dedic A, Van Straten M, Cademartiri F, Hunink
337. Nollen GJ, Kodde J, Beek AM, Res JCJ, van
MGM, Krestin GP, De Feyter PJ, Mollet NR.
Rossum AC. Quadricuspid Pulmonary Valve
Diagnostic Accuracy of 128-Slice Dual-Source Ct
and Left Pulmonary Artery Aneurysm in an
Coronary Angiography: A Randomized Comparison
Asymptomatic Patient Assessed by Cardiovascular
of Different Acquisition Protocols. Eur Radiol.
Mri. Netherlands Heart Journal. 2013;21(4):196-8.
338. Nouwens F, Dippel DW, de Jong-Hagelstein
2013;23(3):614-22.
333. Nieman K, Serruys PW, Onuma Y, Van Geuns RJ,
M, Visch-Brink EG, Koudstaal PJ, de Lau LM,
Garcia-Garcia HM, De Bruyne B, Thuesen L, Smits
investigators R-. Rotterdam Aphasia Therapy Study
PC, Koolen JJ, McClean D, Chevalier B, Meredith
(Rats)-3: “The Efficacy of Intensive Cognitive-
I, Ormiston J. Multislice Computed Tomography
Linguistic Therapy in the Acute Stage of Aphasia”;
Angiography for Noninvasive Assessment of the
Design of a Randomised Controlled Trial. Trials.
18-Month Performance of a Novel Radiolucent
2013;14:24.
Bioresorbable Vascular Scaffolding Device:
339. Nurmohamed SA, Jallah BP, Vervloet MG, Yldirim
The Absorb Trial (a Clinical Evaluation of the
G, ter Wee PM, Groeneveld AB. Continuous
Bioabsorbable Everolimus Eluting Coronary Stent
Venovenous Haemofiltration with Citrate-Buffered
System in the Treatment of Patients with De Novo
Replacement Solution Is Safe and Efficacious in
Native Coronary Artery Lesions). J Am Coll Cardiol.
Patients with a Bleeding Tendency: A Prospective
141
Observational Study. BMC Nephrol. 2013;14:89.
Piazza N, Einthoven J, van Domburg R, Serruys
340. Oei HH, Vliegenthart R, Deckers JW, Hofman
PW. Single-Vessel or Multivessel Pci in Patients
A, Oudkerk M, Witteman JC. The Association
with Multivessel Disease Presenting with Non-
of Rose Questionnaire Angina Pectoris and
St-Elevation Acute Coronary Syndromes.
Coronary Calcification in a General Population:
The Rotterdam Coronary Calcification Study. Ann
346. Onuma Y, Thuesen L, Van Geuns RJ, Van Der Ent M,
Desch S, Fajadet J, Christiansen E, Smits P, Ramsing
Epidemiol. 2004;14(6):431-6.
341. Oei L, Rivadeneira F, Ly F, Breda SJ, Zillikens
Holm N, Regar E, Van Mieghem N, Borovicanin V,
MC, Hofman A, Uitterlinden AG, Krestin GP, Oei
Paunovic D, Senshu K, Van Es GA, Muramatsu
EHG. Review of Radiological Scoring Methods of
T, Lee IS, Schuler G, Zijlstra F, Garcia-Garcia HM,
Osteoporotic Vertebral Fractures for Clinical and
Serruys PW. Randomized Study to Assess the Effect
Research Settings. Eur Radiol. 2013;23(2):476-86.
of Thrombus Aspiration on Flow Area in Patients
342. Onder G, Van der Cammen TJM, Petrovic M,
with St-Elevation Myocardial Infarction: An Optical
Somers A, Rajkumar C. Strategies to Reduce the
Frequency Domain Imaging Study - Trofi Trial. Eur
Risk of Iatrogenic Illness in Complex Older Adults.
Age Ageing. 2013;42(3):284-91.
Heart J. 2013;34(14):1050-60b.
347. Oosterveer DM, Versmissen J, Defesche JC,
343. Onuma Y, Dudek D, Thuesen L, Webster M,
Sivapalaratnam S, Yazdanpanah M, Mulder M,
Nieman K, Garcia-Garcia HM, Ormiston JA,
Van Der Zee L, Uitterlinden AG, Van Duijn CM,
Serruys PW. Five-Year Clinical and Functional
Hofman A, Kastelein JJP, Aulchenko YS, Sijbrands
Multislice Computed Tomography Angiographic
EJG. Low-Density Lipoprotein Receptor Mutations
Results after Coronary Implantation of the Fully
Generate Synthetic Genome-Wide Associations.
Resorbable Polymeric Everolimus-Eluting Scaffold
in Patients with De Novo Coronary Artery Disease:
Eur J Hum Genet. 2013;21(5):563-6.
348. Opić P, Roos-Hesselink JW, Cuypers JAAC,
The Absorb Cohort a Trial. JACC: Cardiovascular
Witsenburg M, Van Den Bosch A, Van Domburg
Interventions. 2013;6(10):999-1009.
RT, Bogers AJJC, Utens EMWJ. Sexual
344. Onuma Y, Miquel-Hebert K, Serruys PW. Five-
Functioning Is Impaired in Adults with Congenital
Year Long-Term Clinical Follow-up of the Xience
V Everolimus-Eluting Coronary Stent System in
Heart Disease. Int J Cardiol. 2013;168(4):3872-7.
349. Opic P, van Kranenburg M, Yap SC, van Dijk AP,
the Treatment of Patients with De Novo Coronary
Budts W, Vliegen HW, van Erven L, Can A, Sahin
Artery Disease: The Spirit Ii Trial. EuroIntervention.
G, Theuns DA, Witsenburg M, Roos-Hesselink JW.
2013;8(9):1047-51.
Complications of Pacemaker Therapy in Adults with
345. Onuma Y, Muramatsu T, Girasis C, Kukreja
Congenital Heart Disease: A Multicenter Study. Int
N, Garcia-Garcia HM, Daemen J, Gonzalo N,
J Cardiol. 2013;168(4):3212-6.
142
350. Opić P, Yap SC, Van Kranenburg M, Van Dijk AP,
Replacement: A Meta-Analysis and Modeling
Budts W, Vliegen HW, Van Erven L, Can A, Sahin
G, De Groot NM, Witsenburg M, Roos-Hesselink
Study. J Am Coll Cardiol. 2013;62(11):1002-12.
356. Osnabrugge RLJ, Speir AM, Head SJ, Fonner
JW. Atrial-Based Pacing Has No Benefit over
CE, Fonner Jr E, Ailawadi G, Kappetein AP, Rich
Ventricular Pacing in Preventing Atrial Arrhythmias
JB. Costs for Surgical Aortic Valve Replacement
in Adults with Congenital Heart Disease. Europace.
According to Preoperative Risk Categories. Ann
2013;15(12):1757-62.
351. Osnabrugge RL, Kappetein AP, Reynolds MR,
Thorac Surg. 2013;96(2):500-6.
357. Ottenhof MJM, Wai MCGTJ, Boiten HJ, Korbee
Cohen DJ. Cost-Effectiveness of Transcatheter
RS, Valkema R, Van Domburg RT, Schinkel
Valvular Interventions: Economic Challenges.
AFL. 12-Year Outcome after Normal Myocardial
EuroIntervention. 2013;9 Suppl:S48-54.
Perfusion Spect in Patients with Known Coronary
352. Osnabrugge RL, Mylotte D, Head SJ, Van
Mieghem NM, Nkomo VT, LeReun CM, Bogers
Artery Disease. J Nucl Cardiol. 2013;20(5):748-54.
358. Oudemans-van Straaten HM, Bouman
AJ, Piazza N, Kappetein AP. Aortic Stenosis in
CSC, Schetz M, Groeneveld ABJ, de Pont
the Elderly: Disease Prevalence and Number
AC, van Alphen AM, de Geus H, Boer W.
of Candidates for Transcatheter Aortic Valve
Recommendations for the Timing and Dosing of
Replacement: A Meta-Analysis and Modeling
Crrt in Critically Ill Patients with Aki. Netherlands
Study. J Am Coll Cardiol. 2013;62(11):1002-12.
Journal of Critical Care. 2013;17(1):10-1.
353. Osnabrugge RLJ, Head SJ, Bogers AJJC,
359. Panasewicz A, Pedersen SS, Veenhuis SJG,
Kappetein AP. Multivessel Coronary Artery
Oemrawsingh RM, Van Der Giessen WJ, Van
Disease: Quantifying How Recent Trials Should
Geuns RJ, Regar E, De Jaegere PP, Serruys PW,
Influence Clinical Practice. Expert Review of
Van Domburg RT. Health-Related Quality of Life
Cardiovascular Therapy. 2013;11(7):903-18.
in the Elderly Three Years after Percutaneous
354. Osnabrugge RLJ, Kappetein AP. Impact of
Coronary Intervention. EuroIntervention.
Methodology and Assumptions in a Cost-
2013;9(3):373-81.
Effectiveness Analysis on Transcatheter Aortic
360. Panfilov IA, De Jong R, Takashima SI, Duckers
Valve Replacement. J Thorac Cardiovasc Surg.
HJ. Clinical Study Using Adipose-Derived
2013;145(2):607.
Mesenchymal-Like Stem Cells in Acute Myocardial
355. Osnabrugge RLJ, Mylotte D, Head SJ, Van
Infarction and Heart Failure. Methods Mol Biol
Mieghem NM, Nkomo VT, Lereun CM, Bogers
AJJC, Piazza N, Kappetein AP. Aortic Stenosis
2013:207-12.
361. Papadopoulou SL, Garcia-Garcia HM, Rossi A,
in the Elderly: Disease Prevalence and Number
Girasis C, Dharampal AS, Kitslaar PH, Krestin
of Candidates for Transcatheter Aortic Valve
GP, de Feyter PJ. Reproducibility of Computed
143
Tomography Angiography Data Analysis Using
and Psychological Morbidity in Implantable
Semiautomated Plaque Quantification Software:
Cardioverter Defibrillator Patients. Int J Cardiol.
Implications for the Design of Longitudinal Studies.
2013;168(1):606-7.
367. Pedersen SS, Hoogwegt MT, Jordaens L, Theuns
Int J Cardiovasc Imaging. 2013;29(5):1095-104.
362. Papadopoulou SL, Girasis C, Dharampal A,
DAMJ. Pre Implantation Psychological Functioning
Farooq V, Onuma Y, Rossi A, Morel MA, Krestin
Preserved in Majority of Implantable Cardioverter
GP, Serruys PW, De Feyter PJ, Garcia Garcia HM.
Defibrillator Patients 12 Months Post Implantation.
Ct-Syntax Score: A Feasibility and Reproducibility
Int J Cardiol. 2013;166(1):215-20.
Study. JACC: Cardiovascular Imaging.
368. Persson F, Lu X, Rossing P, Garrelds IM,
Danser AHJ, Parving HH. Urinary Renin and
2013;6(3):413-5.
363. Papafaklis MI, Bourantas CV, Farooq V, Diletti
Angiotensinogen in Type 2 Diabetes: Added
R, Muramatsu T, Zhang Y, Fotiadis DI, Onuma
Value Beyond Urinary Albumin? J Hypertens.
Y, Garcia Garcia HM, Michalis LK, Serruys PW.
2013;31(8):1646-52.
In Vivo Assessment of the Three-Dimensional
369. Persu A, Lambert M, Deinum J, Cossu M, de
Haemodynamic Micro-Environment Following
Visscher N, Irenge L, Ambroise J, Minon JM,
Drug-Eluting Bioresorbable Vascular Scaffold
Nesterovitch AB, Churbanov A, Popova IA, Danilov
Implantation in a Human Coronary Artery: Fusion of
SM, Danser AH, Gala JL. A Novel Splice-Site
Frequency Domain Optical Coherence Tomography
Mutation in Angiotensin I-Converting Enzyme
and Angiography. EuroIntervention. 2013;9(7):890.
(Ace) Gene, C.3691+1g>a (Ivs25+1g>a), Causes
364. Papma JM, Den Heijer T, De Koning I, Mattace-
a Dramatic Increase in Circulating Ace through
Raso FU, Van Der Lugt A, Van Der Lijn F, Van
Deletion of the Transmembrane Anchor. PLoS
Swieten JC, Koudstaal PJ, Smits M, Prins ND.
The Influence of Cerebral Small Vessel Disease
One. 2013;8(4):e59537.
370. Peters THF, Sharma V, Yilmaz E, Mooi WJ,
on Default Mode Network Deactivation in Mild
Bogers AJJC, Sharma HS. DNA Microarray and
Cognitive Impairment. NeuroImage: Clinical.
Quantitative Analysis Reveal Enhanced Myocardial
2013;2(1):33-42.
Vegf Expression with Stunted Angiogenesis in
365. Pedersen SS, Chaitsing R, Szili-Torok T, Jordaens
Human Tetralogy of Fallot. Cell Biochem Biophys.
L, Theuns DAMJ. Patients’ Perspective on
Deactivation of the Implantable Cardioverter-
2013;67(2):305-16.
371. Piazza N, Kalesan B, Van Mieghem N, Head S,
Defibrillator near the End of Life. Am J Cardiol.
Wenaweser P, Carrel TP, Bleiziffer S, De Jaegere
2013;111(10):1443-7.
PP, Gahl B, Anderson RH, Kappetein AP, Lange
366. Pedersen SS, Hoogwegt MT, Jordaens L, Theuns
R, Serruys PW, Windecker S, Jüni P. A 3-Center
DA. Procedure- and Device-Related Complications
Comparison of 1-Year Mortality Outcomes between
144
Transcatheter Aortic Valve Implantation and
Surgical Aortic Valve Replacement on the Basis of
2013;23(11):1043-9.
376. Ramcharitar S, Serruys P. Magnetic Navigation
Propensity Score Matching among Intermediate-
Wire in Chronic Total Occlusions: A guide to
Risk Surgical Patients. JACC: Cardiovascular
recanalization (eds. R. Waksman and S. Sato),
John Wiley & Sns, Oxford. 2013:85-90.
372. Pieper PG, Balci A, Aarnoudse JG, Kampman
377. Rapp B, Caplan D, Edwards S, Visch-Brink
MAM, Sollie KM, Groen H, Mulder BJM, Oudijk
E, Thompson CK. Neuroimaging in Aphasia
MA, Roos-Hesselink JW, Cornette J, Van Dijk
Treatment Research: Issues of Experimental
APJ, Spaanderman ME, Drenthen W, Van
Design for Relating Cognitive to Neural Changes.
Veldhuisen DJ. Uteroplacental Blood Flow, Cardiac
Neuroimage. 2013;73:200-7.
Function, and Pregnancy Outcome in Women
378. Regar E, Gnanadesigan M, Van Der Steen AFW,
with Congenital Heart Disease. Circulation.
Van Soest G. Quantitative Optical Coherence
2013;128(23):2478-87.
Tomography Tissue-Type Imaging for Lipid-
373. Plenge E, Poot DHJ, Niessen WJ, Meijering E.
Core Plaque Detection. JACC: Cardiovascular
Super-Resolution Reconstruction Using CrossScale Self-Similarity in Multi-Slice Mri. LNCS 2013;
379. Reis Miranda D, Van Thiel R, Gommers D.
Predicting Mortality While on Veno-Venous
8151:123-30.
374. Poppe KK, Squire IB, Whalley GA, Kober L,
Extracorporeal Membrane Oxygenation. Intensive
McAlister FA, McMurray JJ, Pocock S, Earle
NJ, Berry C, Doughty RN, Meta-Analysis
Care Med. 2013;39(9):1669.
380. Ren B, De Groot-De Laat LE, McGhie J, Vletter
Global Group in Chronic Heart F. Known and
WB, Ten Cate FJ, Geleijnse ML. Geometric
Missing Left Ventricular Ejection Fraction
Errors of the Pulsed-Wave Doppler Flow
and Survival in Patients with Heart Failure: A
Method in Quantifying Degenerative Mitral
Maggic Meta-Analysis Report. Eur J Heart Fail.
Valve Regurgitation: A Three-Dimensional
2013;15(11):1220-7.
Echocardiography Study. J Am Soc Echocardiogr.
375. Prudente S, Copetti M, Morini E, Mendonca C,
Andreozzi F, Chandalia M, Baratta R, consortium
2013;26(3):261-9.
381. Ren B, Mulder HW, Haak A, Van Stralen M, Szili-
D, Pellegrini F, Mercuri L, Bailetti D, Abate N,
Torok T, Pluim JPW, Geleijnse ML, Bosch JG.
Frittitta L, Sesti G, Florez JC, Doria A, Trischitta
A Transoesophageal Echocardiographic Image
V. The Sh2b1 Obesity Locus and Abnormal
Acquisition Protocol for Wide-View Fusion of
Glucose Homeostasis: Lack of Evidence for
Three-Dimensional Datasets to Support Atrial
Association from a Meta-Analysis in Individuals of
Fibrillation Catheter Ablation. J Interv Card
European Ancestry. Nutr Metab Cardiovasc Dis.
Electrophysiol. 2013;37(1):21-6.
145
382. Reznik N, Shpak O, Gelderblom EC, Williams R,
Thiazide-Associated Hyponatremia: A Population-
De Jong N, Versluis M, Burns PN. The Efficiency
Based Study. Am J Kidney Dis. 2013;62(1):67-72.
and Stability of Bubble Formation by Acoustic
387. Rodríguez-Mañas L, Féart C, Mann G, Viña J,
Vaporization of Submicron Perfluorocarbon
Chatterji S, Chodzko-Zajko W, Gonzalez-Colaço
Droplets. Ultrasonics. 2013;53(7):1368-76.
Harmand M, Bergman H, Carcaillon L, Nicholson
383. Ribeiro HB, Webb JG, Makkar RR, Cohen MG,
C, Scuteri A, Sinclair A, Pelaez M, Van Der
Kapadia SR, Kodali S, Tamburino C, Barbanti M,
Cammen T, Beland F, Bickenbach J, Delamarche
Chakravarty T, Jilaihawi H, Paradis JM, De Brito
P, Ferrucci L, Fried LP, Gutiérrez-Robledo LM,
Jr FS, Cánovas SJ, Cheema AN, De Jaegere PP,
Rockwood K, Rodríguez Artalejo F, Serviddio G,
Del Valle R, Chiam PTL, Moreno R, Pradas G,
Vega E. Searching for an Operational Definition
Ruel M, Salgado-Fernández J, Sarmento-Leite
of Frailty: A Delphi Method Based Consensus
R, Toeg HD, Velianou JL, Zajarias A, Babaliaros
Statement. The Frailty Operative Definition-
V, Cura F, Dager AE, Manoharan G, Lerakis S,
Consensus Conference Project. Journals of
Pichard AD, Radhakrishnan S, Perin MA, Dumont
Gerontology - Series A Biological Sciences and
E, Larose E, Pasian SG, Nombela-Franco L, Urena
M, Tuzcu EM, Leon MB, Amat-Santos IJ, Leipsic J,
Medical Sciences. 2013;68(1):62-7.
388. Rodríguez-Mañero M, Namdar M, Sarkozy A,
Rodés-Cabau J. Predictive Factors, Management,
Casado-Arroyo R, Ricciardi D, De Asmundis
and Clinical Outcomes of Coronary Obstruction
C, Chierchia GB, Wauters K, Rao JY, Bayrak
Following Transcatheter Aortic Valve Implantation:
F, Van Malderen S, Brugada P. Prevalence,
Insights from a Large Multicenter Registry. J Am
Clinical Characteristics and Management of Atrial
Coll Cardiol. 2013;62(17):1552-62.
Fibrillation in Patients with Brugada Syndrome. Am
384. Richardt G, Leschke M, Abdel-Wahab M, Toelg R,
J Cardiol. 2013;111(3):362-7.
El-Mawardy M, Serruys PW, Silber S, Windecker S,
389. Roksnoer LCW, Verdonk K, Van Den Meiracker
Belardi JA, Neumann FJ, Widimsky P, Comers RA,
AH, Hoorn EJ, Zietse R, Danser AHJ. Urinary
Investigators RI. Clinical Outcomes of the Resolute
Markers of Intrarenal Renin-Angiotensin System
Zotarolimus-Eluting Stent in Patients with in-Stent
Activity in Vivo. Current Hypertension Reports.
Restenosis: 2-Year Results from a Pooled Analysis.
2013;15(2):81-8.
JACC Cardiovasc Interv. 2013;6(9):905-13.
390. Roos-Hesselink JW, Johnson MR. Does Fertility
385. Robinson D, Mees B, Verhagen H, Chuen J. Aortic
Therapy Hamper Cardiovascular Outcome? J Am
Aneurysms: Screening, Surveillance and Referral.
Aust Fam Physician. 2013;42(6):364-9.
Coll Cardiol. 2013;62(18):1713-4.
391. Roos-Hesselink JW, Ruys PTE, Johnson MR.
386. Rodenburg EM, Hoorn EJ, Ruiter R, Lous JJ,
Pregnancy in Adult Congenital Heart Disease.
Hofman A, Uitterlinden AG, Stricker BH, Visser LE.
Current Cardiology Reports. 2013;15(9).
146
392. Roos-Hesselink JW, Ruys TPE, Stein JI, Thilén U,
Witsenburg M, Helbing WA, Bogers AJJC, van
Webb GD, Niwa K, Kaemmerer H, Baumgartner H,
Domburg R, McGhie JS, Geleijnse ML, Henrichs
Budts W, Maggioni AP, Tavazzi L, Taha N, Johnson
J, Utens E, Van der Zwaan HB, Takkenberg JJM,
MR, Hall R. Outcome of Pregnancy in Patients with
Roos-Hesselink JW. Long-Term Outcome and
Structural or Ischaemic Heart Disease: Results of
Quality of Life after Arterial Switch Operation: A
a Registry of the European Society of Cardiology.
Prospective Study with a Historical Comparison.
Eur Heart J. 2013;34(9):657-65.
Congenital Heart Disease. 2013;8(3):203-10.
393. Rossi A, Uitterdijk A, Dijkshoorn M, Klotz E,
398. Ruzsa Z, van der Linden M, Van Mieghem NM,
Dharampal A, Van Straten M, Van Der Giessen
Regar E, Ligthart JM, Serruys P, van Geuns RJ.
WJ, Mollet N, Van Geuns RJ, Krestin GP, Duncker
Culotte Stenting with Bioabsorbable Everolimus-
DJ, De Feyter PJ, Merkus D. Quantification of
Eluting Stents. Int J Cardiol. 2013;168(2):e35-7.
Myocardial Blood Flow by Adenosine-Stress
399. Sanders YV, Eikenboom J, de Wee EM, van der
Ct Perfusion Imaging in Pigs During Various
Bom JG, Cnossen MH, Degenaar-Dujardin MEL,
Degrees of Stenosis Correlates Well with Coronary
Fijnvandraat K, Kamphuisen PW, Laros-van
Artery Blood Flow and Fractional Flow Reserve.
Gorkom BAP, Meijer K, Mauser-Bunschoten EP,
European Heart Journal Cardiovascular Imaging.
Leebeek FWG, Kors A, Zweegman S, Goverde
2013;14(4):331-8.
GJ, Jonkers MH, Dors N, Nijziel MR, Meijer
394. Rossi A, Van Der Linde D, Yap SC, Lapinskas
K, Tamminga RYJ, van der Linden PW, Ypma
T, Kirschbaum S, Springeling T, Witsenburg M,
PF, Eikenboom HCJ, Smiers FJW, Granzen
Cuypers J, Moelker A, Krestin GP, Van Dijk A,
B, Hamulyák K, Brons P, de Goede-Bolder A.
Johnson M, Van Geuns RJ, Roos-Hesselink JW.
Reduced Prevalence of Arterial Thrombosis in Von
Ascending Aorta Dilatation in Patients with Bicuspid
Willebrand Disease. Journal of Thrombosis and
Aortic Valve Stenosis: A Prospective Cmr Study.
Haemostasis. 2013;11(5):845-54.
Eur Radiol. 2013;23(3):642-9.
400. Satoer D, Vincent A, Smits M, Dirven C, Visch-
395. Ruggiero A, Guenoun J, Smit H, Doeswijk GN,
Brink E. Spontaneous Speech of Patients with
Klein S, Krestin GP, Kotek G, Bernsen MR. In Vivo
Gliomas in Eloquent Areas before and Early after
Mri Mapping of Iron Oxide-Labeled Stem Cells
Surgery. Acta Neurochir (Wien). 2013;155(4):685-
Transplanted in the Heart. Contrast Media and
92.
Molecular Imaging. 2013;8(6):487-94.
401. Saxena R, Saleheen D, Been LF, Garavito ML,
396. Ruys TPE, Cornette J, Roos-Hesselink JW.
Braun T, Bjonnes A, Young R, Ho WK, Rasheed
Pregnancy and Delivery in Cardiac Disease. J
A, Frossard P, Sim X, Hassanali N, Radha V,
Cardiol. 2013;61(2):107-12.
Chidambaram M, Liju S, Rees SD, Ng DP, Wong
397. Ruys TPE, van der Bosch AE, Cuypers JAAE,
TY, Yamauchi T, Hara K, Tanaka Y, Hirose H,
147
McCarthy MI, Morris AP, Diagram, MuTher, Agen,
405. Schaer BA, Hitz L, Sticherling C, Kühne M,
Basit A, Barnett AH, Katulanda P, Matthews D,
Dickenmann M, Jordaens L, Osswald S, Theuns
Mohan V, Wander GS, Singh JR, Mehra NK,
DA. Changes in Renal Function over Time in
Ralhan S, Kamboh MI, Mulvihill JJ, Maegawa
Patients with Cardiac Resynchronisation Therapy.
H, Tobe K, Maeda S, Cho YS, Tai ES, Kelly MA,
Swiss Medical Weekly. 2013;143: w13863
Chambers JC, Kooner JS, Kadowaki T, Deloukas
406. Schalekamp MADH, Danser AHJ. How Does the
P, Rader DJ, Danesh J, Sanghera DK. Genome-
Angiotensin Ii Type 1 Receptor ‘Trump’ the Type 2
Wide Association Study Identifies a Novel Locus
Receptor in Blood Pressure Control? J Hypertens.
Contributing to Type 2 Diabetes Susceptibility
in Sikhs of Punjabi Origin from India. Diabetes.
2013;31(4):705-12.
407. Schalekamp MADH, Danser AHJ. Response
to ‘Angiotensin Ii Type 1 and Type 2 Receptor
2013;62(5):1746-55.
402. Schaap J, De Groot JAH, Nieman K, Meijboom
Interplay in Hypertension: Lesson from a Human
WB, Boekholdt SM, Post MC, Van Der Heyden
Model of Vascular Hyporeactivity’. J Hypertens.
JAS, De Kroon TL, Rensing BJWM, Moons KGM,
2013;31(5):1056-7.
Verzijlbergen JF. Hybrid Myocardial Perfusion
408. Schinkel AFL. Implantable Cardioverter
Spect/Ct Coronary Angiography and Invasive
Defibrillators in Arrhythmogenic Right Ventricular
Coronary Angiography in Patients with Stable
Dysplasia/Cardiomyopathy: Patient Outcomes,
Angina Pectoris Lead to Similar Treatment
Incidence of Appropriate and Inappropriate
Decisions. Heart. 2013;99(3):188-94.
Interventions, and Complications. Circulation:
403. Schaap J, De Groot JAH, Nieman K, Meijboom
WB, MatthijsBoekholdt S, Post MC, Van Der
Arrhythmia and Electrophysiology. 2013;6(3):562-8.
409. Segers D, Galuzina J, Verdijk RM, Manintveld OC.
Heyden JA, De Kroon TL, Rensing BJWM,
Right Atrial and Ventricular Angiosarcoma. Eur
Moons KGM, Verzijlbergen JF. Postscript. Heart.
Heart J. 2013;34(43):3361.
2013;99(15):1136-7.
410. Selwaness M, Van Den Bouwhuijsen QJA,
404. Schaap J, Kauling RM, Matthijs Boekholdt S,
Verwoert GC, Dehghan A, Mattace-Raso FUS,
Nieman K, Bob Meijboom W, Post MC, Van Der
Vernooij M, Franco OH, Hofman A, Van Der
Heyden JA, De Kroon TL, Wouter Van Es H,
Lugt A, Wentzel JJ, Witteman JCM. Blood
Rensing BJ, Fred Verzijlbergen J. Incremental
Pressure Parameters and Carotid Intraplaque
Diagnostic Accuracy of Hybrid Spect/Ct Coronary
Hemorrhage as Measured by Magnetic Resonance
Angiography in a Population with an Intermediate
Imaging: The Rotterdam Study. Hypertension.
to High Pre-Test Likelihood of Coronary Artery
Disease. European Heart Journal Cardiovascular
2013;61(1):76-81.
411. Senior R, Moreo A, Gaibazzi N, Agati L, Tiemann
K, Shivalkar B, Von Bardeleben S, Galiuto L,
Imaging. 2013;14(7):642-9.
148
Lardoux H, Trocino G, Carrió I, Le Guludec D,
Sambuceti G, Becher H, Colonna P, Ten Cate
2013;9(7):775.
418. Serruys PW. A Sense of “Deja Vu”?
F, Bramucci E, Cohen A, Bezante G, Aggeli C,
Kasprzak JD. Comparison of Sulfur Hexafluoride
EuroIntervention. 2013;9(5):535.
419. Serruys PW. Tavi in Europe - That Was Then and
Microbubble (Sonovue)-Enhanced Myocardial
This Is Now. EuroIntervention. 2013;9(4):415-7.
Contrast Echocardiography with Gated Single-
420. Serruys PW. Cost-Effectiveness: The Menage a
Photon Emission Computed Tomography for
Trois Having a Ratio with One Denominator and
Detection of Significant Coronary Artery Disease:
One Numerator. EuroIntervention. 2013;9(2):173.
A Large European Multicenter Study. J Am Coll
421. Serruys PW. The Great Ifr Vs. Ffr Debate: Why
Sometimes “the Wait and See Approach” Is
Cardiol. 2013;62(15):1353-61.
412. Sequeira V, Wijnker PJM, Nijenkamp LLAM, Kuster
the Best Tactic as the Best Pragmatic Solution
DWD, Najafi A, Witjas-Paalberends ER, Regan
Will Always Emerge and Become Established.
JA, Boontje N, Ten Cate FJ, Germans T, Carrier L,
Sadayappan S, Van Slegtenhorst MA, Zaremba R,
422. Serruys PW. Travelling around the World with
Foster DB, Murphy AM, Poggesi C, Dos Remedios
Interventional Cardiology. EuroIntervention.
C, Stienen GJM, Ho CY, Michels M, Van Der
2013;8(12):1347.
Velden J. Perturbed Length-Dependent Activation
423. Serruys PW, Farooq V. Revascularization
in Human Hypertrophic Cardiomyopathy with
Strategies in Patients with Diabetes [4]. N Engl J
Missense Sarcomeric Gene Mutations. Circ Res.
Med. 2013;368(15):1454-5.
2013;112(11):1491-505.
424. Serruys PW, Farooq V, Kalesan B, De Vries T,
413. Serruys PW. The Authors’ Challenge.
Buszman P, Linke A, Ischinger T, Klauss V, Eberli F,
Wijns W, Morice MC, Di Mario C, Corti R, Antoni D,
414. Serruys PW. On Eeps and E-Blasts, Cluster
Sohn HY, Eerdmans P, Rademaker-Havinga T, Van
Publishing, Consensus and Interventional
Es GA, Meier B, Jüni P, Windecker S. Improved
Cardiology. EuroIntervention. 2013;8(11):1229.
Safety and Reduction in Stent Thrombosis
415. Serruys PW. Full Circle: From Thrombolysis
Associated with Biodegradable Polymer-Based
to Pci Post-Thrombolysis, to Thrombolysis
Biolimus-Eluting Stents Versus Durable Polymer-
with Pci, to Pci Alone to Thrombectomy
Based Sirolimus-Eluting Stents in Patients with
Alone, to Nanothrombolysis. EuroIntervention.
Coronary Artery Disease: Final 5-Year Report
2013;8(10):1112-3.
of the Leaders (Limus Eluted from a Durable
416. Serruys PW. Reflections on Stemi.
Versus Erodable Stent Coating) Randomized,
Noninferiority Trial. JACC: Cardiovascular
417. Serruys PW. Asia Rising. EuroIntervention.
149
425. Sevá Pessôa B, Van Der Lubbe N, Verdonk
N, Fowlkes B, Fabiilli M, Versluis M. Ultrafast
K, Roks AJM, Hoorn EJ, Danser AHJ. Key
Dynamics of the Acoustic Vaporization of
Developments in Renin-Angiotensin-Aldosterone
Phase-Change Microdroplets. J Acoust Soc Am.
System Inhibition. Nature Reviews Nephrology.
2013;9(1):26-36.
2013;134(2):1610-21.
431. Shurrab M, Danon A, Lashevsky I, Kiss A,
426. Shahzad R, Bos D, Metz C, Rossi A, Kirişli H,
Newman D, Szili-Torok T, Crystal E. Robotically
Van Der Lugt A, Klein S, Witteman J, De Feyter
Assisted Ablation of Atrial Fibrillation: A
P, Niessen W, Van Vliet L, Van Walsum T.
Systematic Review and Meta-Analysis. Int J
Automatic Quantification of Epicardial Fat Volume
on Non-Enhanced Cardiac Ct Scans Using a
Cardiol. 2013;169(3):157-65.
432. Silber S, Serruys PW, Leon MB, Meredith IT,
Multi-Atlas Segmentation Approach. Med Phys.
Windecker S, Neumann FJ, Belardi J, Widimsky
2013;40(9).091910
P, Massaro J, Novack V, Yeung AC, Saito S, Mauri
427. Shahzad R, Kirişli H, Metz C, Tang H, Schaap
L. Clinical Outcome of Patients with and without
M, Van Vliet L, Niessen W, Van Walsum T.
Diabetes Mellitus after Percutaneous Coronary
Automatic Segmentation, Detection and
Intervention with the Resolute Zotarolimus-Eluting
Quantification of Coronary Artery Stenoses on Cta.
Stent: 2-Year Results from the Prospectively
International Journal of Cardiovascular Imaging.
Pooled Analysis of the International Global
2013;29(8):1847-59.
Resolute Program. JACC: Cardiovascular
428. Shahzad R, van Walsum T, Schaap M, Rossi A,
Klein S, Weustink AC, de Feyter PJ, van Vliet
433. Simoons ML. Costs and Benefits of Treatment of
LJ, Niessen WJ. Vessel Specific Coronary Artery
Myocardial Infarction. Netherlands Heart Journal.
Calcium Scoring. An Automatic System. Acad
Radiol. 2013;20(1):1-9.
2013;21(5):228-9.
434. Simsek C, Räber L, Magro M, Boersma E, Onuma
429. Shiratori Y, Brugaletta S, Alvarez-Contreras L,
Y, Stefanini GG, Zanchin T, Kalesan B, Wenaweser
Azpeitia Y, Ospino N, Gaido S, Delahanty A,
P, Jüni P, Van Geuns RJ, Van Domburg RT,
Santos A, Martin-Yuste V, Masotti M, Serruys
Windecker S, Serruys PWJC. Long-Term Outcome
PW, Windecker S, Sabate M. One-Year Head to
of the Unrestricted Use of Everolimus-Eluting
Head Comparison of the Neointimal Response
Stents Compared to Sirolimus-Eluting Stents and
between Sirolimus Eluting Stent with Reservoir
Paclitaxel-Eluting Stents in Diabetic Patients:
Technology and Everolimus Eluting Stent: An
The Bern-Rotterdam Diabetes Cohort Study. Int J
Optical Coherence Tomography Study. Catheter
Cardiovasc Interv. 2013;82(4):E428-36.
Cardiol. 2013;170(1):36-42.
435. Singaraja RR, Sivapalaratnam S, Hovingh K,
430. Shpak O, Kokhuis TJ, Luan Y, Lohse D, de Jong
Dubé MP, Castro-Perez J, Collins HL, Adelman
150
SJ, Riwanto M, Manz J, Hubbard B, Tietjen I,
of Portal Vein Thrombosis. Thromb Haemost.
Wong K, Mitnaul LJ, Van Heek M, Lin L, Roddy TA,
2013;109(3):558-60.
McEwen J, Dallinge-Thie G, Van Vark-Van Der Zee
440. Smith T, Jordaens L, Theuns DAMJ, Van Dessel
L, Verwoert G, Winther M, Van Duijn C, Hofman A,
PF, Wilde AA, Myriam Hunink MG. The Cost-
Trip MD, Marais AD, Asztalos B, Landmesser U,
Effectiveness of Primary Prophylactic Implantable
Sijbrands E, Kastelein JJ, Hayden MR. The Impact
Defibrillator Therapy in Patients with Ischaemic
of Partial and Complete Loss-of-Function Mutations
or Non-Ischaemic Heart Disease: A European
in Endothelial Lipase on High-Density Lipoprotein
Analysis. Eur Heart J. 2013;34(3):211-9.
Levels and Functionality in Humans. Circulation:
441. Smith T, Theuns DA, Muskens-Heemskerk A,
Deckers JW, Jordaens L. Survivors of Ventricular
Cardiovascular Genetics. 2013;6(1):54-62.
436. Siregar S, Groenwold RHH, Versteegh MIM,
Fibrillation Have Persistent Cardiovascular Risk
Takkenberg JJM, Bots ML, van der Graaf Y, van
Factors Late in Follow-Up. European Journal of
Herwerden LA. Data Resource Profile: Adult
Preventive Cardiology. 2013;20(1):161-7.
Cardiac Surgery Database of the Netherlands
442. Smorenberg A, Lust EJ, Beishuizen A, Meijer
Association for Cardio-Thoracic Surgery. Int J
JH, Verdaasdonk RM, Groeneveld ABJ.
Epidemiol. 2013;42(1):142-9.
Systolic Time Intervals Vs Invasive Predictors
437. Skillington PD, Mokhles MM, Takkenberg JJ,
of Fluid Responsiveness after Coronary Artery
O’Keefe M, Grigg L, Wilson W, Larobina M, Tatoulis
Bypass Surgery. Eur J Cardiothorac Surg.
J. Twenty-Year Analysis of Autologous Support of
2013;44(5):891-7.
the Pulmonary Autograft in the Ross Procedure.
443. Snelder SM, Nauta ST, Akkerhuis KM, Deckers
JW, van Domburg RT. Weekend Versus Weekday
Ann Thorac Surg. 2013;96(3):823-9.
438. Slagt C, De Leeuw MA, Beute J, Rijnsburger E,
Mortality in St-Segment Elevation Acute Myocardial
Hoeksema M, Mulder JWR, Malagon I, Groeneveld
Infarction Patients between 1985 and 2008. Int J
ABJ. Cardiac Output Measured by Uncalibrated
Arterial Pressure Waveform Analysis by Recently
Cardiol. 2013;168(2):1576-7.
444. Soliman OII, Anwar AM, Metawei AK, McGhie JS,
Released Software Version 3.02 Versus
Geleijnse ML, Ten Cate FJ. New Scores for the
Thermodilution in Septic Shock. J Clin Monit
Assessment of Mitral Stenosis Using Real-Time
Comput. 2013;27(2):171-7.
Three-Dimensional Echocardiography. Current
439. Smalberg JH, Koehler E, Murad SD, Plessier A,
Seijo S, Trebicka J, Primignani M, Rijken DC, de
Cardiovascular Imaging Reports. 2011;4(5):370-7.
445. Sonneveld MAH, van Dijk AC, van den Herik
Maat MPM, Garcia-Pagan JC, Valla DC, Janssen
EG, van Loon JE, de Lau LML, van der Lugt A,
HLA, Leebeek FWG. Fibrinogen Γ’ and Variation
Koudstaal PJ, de Maat MPM, Leebeek FWG.
in Fibrinogen Gamma Genes in the Etiology
Relationship of Von Willebrand Factor with Carotid
151
Artery and Aortic Arch Calcification in Ischemic
Survival in Patients Who Received Crrt. Clinical
Stroke Patients. Atherosclerosis. 2013;230(2):210-
Journal of the American Society of Nephrology.
5.
2013;8(8):1284-91.
446. Spaander MCW, Hoekstra J, Hansen BE, Van
451. Stefanini GG, Baber U, Windecker S, Morice MC,
Buuren HR, Leebeek FWG, Janssen HLA.
Sartori S, Leon MB, Stone GW, Serruys PW, Wijns
Anticoagulant Therapy in Patients with Non-
W, Weisz G, Camenzind E, Steg PG, Smits PC,
Cirrhotic Portal Vein Thrombosis: Effect on New
Kandzari D, Von Birgelen C, Galatius S, Jeger
Thrombotic Events and Gastrointestinal Bleeding.
RV, Kimura T, Mikhail GW, Itchhaporia D, Mehta
Journal of Thrombosis and Haemostasis.
L, Ortega R, Kim HS, Valgimigli M, Kastrati A,
2013;11(3):452-9.
Chieffo A, Mehran R. Safety and Effi Cacy of
447. Spoto B, Mattace-Raso F, Sijbrands E, Pizzini
Drug-Eluting Stents in Women: A Patient-Level
P, Cutrupi S, D’Arrigo G, Tripepi G, Zoccali
Pooled Analysis of Randomised Trials. Lancet.
C, Mallamaci F. Resistin and All-Cause and
2013;382(9908):1879-88.
Cardiovascular Mortality: Effect Modification
452. Steg G, James SK, Atar D, Badano LP, Blomstrom
by Adiponectin in End-Stage Kidney Disease
Lundqvist C, M AB, di Mario C, Dickstein K,
Patients. Nephrology Dialysis Transplantation.
Ducrocq G, Fernandez-Aviles F, A HG, Giannuzzi
2013;28(SUPPL.4):iv181-7.
P, Halvorsen S, Huber K, Juni P, Kastrati A,
448. Springeling T, Kirschbaum SW, Rossi A, Baks T,
Knuuti J, M JL, K WM, Valgimigli M, Van’t Hof A,
Karamermer Y, Schulz C, Ouhlous M, Duncker DJ,
Widimsky P, Zahger D, Comite de la ESCpgdpc, J
Moelker A, Krestin GP, Serruys PWJC, de Feyter
JB, Baumgartner H, Ceconi C, Dean V, Deaton C,
P, van Geuns RJM. Late Cardiac Remodeling after
Fagard R, Funck-Brentano C, Hasdai D, Hoes A,
Primary Percutaneous Coronary Intervention: Five-
Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin
Year Cardiac Magnetic Resonance Imaging Follow-
C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA,
Up. Circulation Journal. 2013;77(1):81-8.
Tendera M, Torbicki A, Vahanian A, Windecker
449. Springeling T, Uitterdijk A, Rossi A, Gorsse-Bakker
S, Revisores del Documento: David H, Astin F,
C, Wielopolski PA, Van Der Giessen WJ, Krestin
Astrom-Olsson K, Budaj A, Clemmensen P, Collet
GP, De Feyter PJ, Duncker DJ, Van Geuns RJM.
JP, Fox KA, Fuat A, Gustiene O, Hamm CW,
Evolution of Reperfusion Post-Infarction Ventricular
Kala P, Lancellotti P, Pietro Maggioni A, Merkely
Remodeling: New Mri Insights. Int J Cardiol.
B, Neumann FJ, Piepoli MF, Werf F, Verheugt F,
2013;169(5):354-8.
Wallentin L. Grupo De Trabajo Para El Manejo
450. Stads S, Fortrie G, Van Bommel J, Zietse R,
Del Infarto Agudo De Miocardio Con Elevacion
Betjes MGH. Impaired Kidney Function at Hospital
Del Segmento St De La Sociedad Europea De
Discharge and Long-Term Renal and Overall
Cardiologia (Esc). Rev Esp Cardiol. 2013;66(1):53
152
van der Heijden AJ, Jaddoe VWV. Parental
e1- e46.
453. Stoof SCM, Sanders YV, Petrij F, Cnossen MH, de
Psychological Distress During Pregnancy
Maat MPM, Leebeek FWG, Kruip MJHA. Response
and Childhood Cardiovascular Development.
to Desmopressin Is Strongly Dependent on F8 Gene
The Generation R Study. Early Hum Dev.
Mutation Type in Mild and Moderate Haemophilia A.
2013;89(8):547-53.
Thromb Haemost. 2013;109(3):440-9.
459. Taal HR, de Jonge LL, van Osch-Gevers L,
454. Sun W, Niessen WJ, Van Stralen M, Klein S.
Steegers EAP, Hofman A, Helbing WA, van der
Simultaneous Multiresolution Strategies for
Heijden AJ, Jaddoe VWV. Parental Smoking During
Nonrigid Image Registration. IEEE Transactions on
Pregnancy and Cardiovascular Structures and
Image Processing. 2013;22(12):4905-17.
Function in Childhood: The Generation R Study. Int
455. Sunamura M, Ter Hoeve N, Van den Berg-Emons
HJG, Haverkamp M, Redekop K, Geleijnse ML,
J Epidemiol. 2013;42(5):1371-80.
460. Takashima SI, Tempel D, Duckers HJ. Current
Stam HJ, Boersma E, van Domburg RT. Optimal
Outlook of Cardiac Stem Cell Therapy Towards a
Cardiac Rehabilitation (Opticare) Following Acute
Clinical Application. Heart. 2013;99(23):1772-84.
Coronary Syndromes: Rationale and Design of a
461. Takkenberg JJM, Klautz RJM. Anticoagulation and
Randomised, Controlled Trial to Investigate the
Bioprosthetic Aortic Valve Replacement: Sense and
Benefits of Expanded Educational and Behavioural
Nonsense. Antistolling en aortaklepbioprotheses:
Intervention Programs. Netherlands Heart Journal.
zin en onzin. Ned Tijdschrift Geneesk 2013;21(7-8):324-30.
2013;157:A6100.
456. Szentpáli Z, Szili-Torok T, Caliskan K. Primary
462. Takkenberg JJM. Dynamic Trends in Cardiac
Electrical Disorder or Primary Cardiomyopathy?: A
Surgery Require Dynamic Models. Eur J
Case with a Unique Association of Noncompaction
Cardiomyopathy and Cathecolaminergic
Cardiothorac Surg. 2013;43(6):1153.
463. Talens S, Malfliet JJMC, Leebeek FWG, Rijken
Polymorphic Ventricular Tachycardia Caused
DC. Oxidized High-Density Lipoprotein Reduces
by Ryanodine Receptor Mutation. Circulation.
Blood Clot Firmness. Journal of Thrombosis and
2013;127(10):1165-6.
457. Szymanski MK, Hillege HL, Danser AHJ, Garrelds
Haemostasis. 2013;11(3):561-3.
464. Talens S, Malfliet JJMC, van Hal PTW,
IM, Schoemaker RG. Elevated Sensitivity
Leebeek FWG, Rijken DC. Identification and
to Cardiac Ischemia in Proteinuric Rats Is
Characterization of Α1-Antitrypsin in Fibrin
Independent of Adverse Cardiac Remodeling. J
Clots. Journal of Thrombosis and Haemostasis.
Hypertens. 2013;31(5):966-74.
458. Taal HR, de Jonge LL, Tiemeier H, van Osch-
2013;11(7):1319-28.
465. Tang H, van Walsum T, Hameeteman R, Shahzad
Gevers L, Hofman A, Verhulst FC, Helbing WA,
R, van Vliet LJ, Niessen WJ. Lumen Segmentation
153
and Stenosis Quantification of Atherosclerotic
with Heterozygous Familial Hypercholesterolemia.
Carotid Arteries in Cta Utilizing a Centerline
Am J Cardiol. 2013;111(9):1305-10.
Intensity Prior. Med Phys. 2013;40(5):051721.
471. Ten Kate GL, Van Den Oord SCH, Sijbrands
466. Taverne YJ, Bogers AJ, Duncker DJ, Merkus D.
EJG, Van Der Lugt A, De Jong N, Bosch JG, Van
Reactive Oxygen Species and the Cardiovascular
Der Steen AFW, Schinkel AFL. Current Status
System. Oxid Med Cell Longev. 2013;2013:862423.
and Future Developments of Contrast-Enhanced
467. Ten Cate DF, Luime JJ, van der Ven M, Hazes JM,
Ultrasound of Carotid Atherosclerosis. J Vasc Surg.
Kooiman K, de Jong N, Bosch JG. Very Different
Performance of the Power Doppler Modalities of
2013;57(2):539-46.
472. Ten Kate GL, Van Dijk AC, Van Den Oord SCH,
Several Ultrasound Machines Ascertained by a
Hussain B, Verhagen HJM, Sijbrands EJG, Van
Microvessel Flow Phantom. Arthritis Res Ther.
Der Steen AFW, Van Der Lugt A, Schinkel AFL.
2013;15(5):R162.
Usefulness of Contrast-Enhanced Ultrasound for
468. Ten Kate GJR, Caliskan K, Dedic A, Meijboom WB,
Detection of Carotid Plaque Ulceration in Patients
Neefjes LA, Manintveld OC, Krenning BJ, Ouhlous
with Symptomatic Carotid Atherosclerosis. Am J
M, Nieman K, Krestin GP, De Feyter PJ. Computed
Tomography Coronary Imaging as a Gatekeeper
Cardiol. 2013;112(2):292-8.
473. Theil AF, Nonnekens J, Steurer B, Mari PO,
for Invasive Coronary Angiography in Patients
de Wit J, Lemaitre C, Marteijn JA, Raams A,
with Newly Diagnosed Heart Failure of Unknown
Maas A, Vermeij M, Essers J, Hoeijmakers JH,
Aetiology. European Journal of Heart Failure.
Giglia-Mari G, Vermeulen W. Disruption of Ttda
2013;15(9):1028-34.
Results in Complete Nucleotide Excision Repair
469. ten Kate GJR, Neefjes LA, Dedic A, Nieman K,
Deficiency and Embryonic Lethality. PLoS Genet.
Langendonk JG, Galema-Boers AJ, Roeters van
Lennep J, Moelker A, Krestin GP, Sijbrands EJ, de
2013;9(4):e1003431.
474. Theuns DAMJ. How to Present Treatment
Feyter PJ. The Effect of Ldlr-Negative Genotype
Effects of Implantable Defibrillators? Statistics,
on Ct Coronary Atherosclerosis in Asymptomatic
Baseline Risk, and Meaningful Benefit. Europace.
Statin Treated Patients with Heterozygous
Familial Hypercholesterolemia. Atherosclerosis.
2013;15(6):777-8.
475. Thomas DH, Sboros V, Emmer M, Vos H, de Jong
N. Microbubble Oscillations in Capillary Tubes.
2013;227(2):334-41.
470. Ten Kate GL, Ten Kate GJR, Van Den Oord SCH,
IEEE Transactions on Ultrasonics, Ferroelectrics,
Dedic A, Dharampal AS, Nieman K, De Feyter
PJ, Sijbrands EJG, Van Der Steen AFW, Schinkel
and Frequency Control. 2013;60(1):105-14.
476. Timmermans L, Klitsie PJ, Maat APWM, De Goede
AFL. Carotid Plaque Burden as a Measure of
B, Kleinrensink GJ, Lange JF. Abdominal Wall
Subclinical Coronary Artery Disease in Patients
Bulging after Thoracic Surgery, an Underdiagnosed
154
Wound Complication. Hernia. 2013;17(1):89-94.
477. Tolenaar JL, van Keulen JW, Jonker FH, van
Haemostasis. 2013;11(11):2029-36.
484. Uittenboogaard LM, Payan-Gomez C, Pothof
Herwaarden JA, Verhagen HJ, Moll FL, Muhs
J, van Ijcken W, Mastroberardino PG, van der
BE, Trimarchi S. Morphologic Predictors of Aortic
Pluijm I, Hoeijmakers JHJ, Tresini M. Bach2: A
Dilatation in Type B Aortic Dissection. J Vasc Surg.
Marker of DNA Damage and Ageing. DNA Repair.
2013;58(5):1220-5.
2013;12(11):982-92.
478. Tolenaar JL, Van Keulen JW, Trimarchi S, Jonker
485. Uitterdijk A, Sneep S, van Duin RWB,
FHW, Van Herwaarden JA, Verhagen HJM, Moll
Krabbendam-Peters I, Gorsse-Bakker C, Duncker
FL, Muhs BE. Number of Entry Tears Is Associated
DJ, van der Giessen WJ, van Beusekom HMM.
with Aortic Growth in Type B Dissections. Ann
Serial Measurement of Hfabp and High-Sensitivity
Troponin I Post-Pci in Stemi: How Fast and
Thorac Surg. 2013;96(1):39-42.
479. Trimarchi S, Tolenaar JL, Jonker FHW, Murray
Accurate Can Myocardial Infarct Size and No-
B, Tsai TT, Eagle KA, Rampoldi V, Verhagen
Reflow Be Predicted? American Journal of
HJM, Van Herwaarden JA, Moll FL, Muhs
Physiology - Heart and Circulatory Physiology.
BE, Elefteriades JA. Importance of False
Lumen Thrombosis in Type B Aortic Dissection
2013;305(7):H1104-H10.
486. Vahanian A, Alfieri O, Andreotti F, Antunes MJ,
Prognosis. J Thorac Cardiovasc Surg. 2013;145(3
Barón-Esquivias G, Baumgartner H, Borger
SUPPL.):S208-S12.
MA, Carrel TP, De Bonis M, Evangelista A,
480. Trof RJ, Danad I, Groeneveld AJ. Global End-
Falk V, Iung B, Lancellotti P, Pierard L, Price S,
Diastolic Volume Increases to Maintain Fluid
Schäfers HJ, Schuler G, Stepinska J, Swedberg
Responsiveness in Sepsis-Induced Systolic
K, Takkenberg J, Von Oppell UO, Windecker S,
Dysfunction. BMC Anesthesiol. 2013;13(1):12.
Zamorano JL, Zembala M. Guidelines for the
481. Tu W, Eckert GJ, Pratt JH, Danser AH. Response
Treatment of Valvular Heart Disease (Version
to “Is High Prorenin Level Related to Relative
2012). Joint Task Force for the Treatment of
Aldosterone Excess?”. Am J Hypertens.
Valvular Heart Disease of the European Society
2013;26(2):154-5.
of Cardiology (Esc) and the European Association
482. Tzikas A, Van Der Boon RM, De Jaegere PP.
for Cardiothoracic Surgery (Eacts). Linee Guida
Contrast Aortography and the Aortic Annulus.
Per Il Trattamento Delle Valvulopatie (Versione
Catheter Cardiovasc Interv. 2013;81(7):1254.
2012). Task Force Congiunta Per Il Trattamento
483. Uitte de Willige S, Malfliet JJMC, Janssen HLA,
Delle Valvulopatie Della Società Europea Di
Leebeek FWG, Rijken DC. Increased N-Terminal
Cardiologia (Esc) E Dell’associazione Europea Di
Cleavage of Alpha-2-Antiplasmin in Patients
Chirurgia Cardiotoracica (Eacts). G Ital Cardiol.
with Liver Cirrhosis. Journal of Thrombosis and
2013;14(3):167-214.
155
487. Valentijn TM, Galal W, Hoeks SE, van Gestel
Response to Cardiac Resynchronization Therapy
YR, Verhagen HJ, Stolker RJ. Impact of Obesity
Is Associated with Improved Clinical Outcome and
on Postoperative and Long-Term Outcomes in
Absence of Appropriate Shocks. J Cardiovasc
a General Surgery Population: A Retrospective
Electrophysiol. 2013;24(3):316-22.
Cohort Study. World J Surg. 2013:37(11):2561-8.
494. Van Dalen BM, Tzikas A, Soliman OII, Heuvelman
488. Valentijn TM, Galal W, Tjeertes EKM, Hoeks
HJ, Vletter WB, Ten Cate FJ, Geleijnse ML.
SE, Verhagen HJ, Stolker RJ. The Obesity
Assessment of Subendocardial Contractile
Paradox in the Surgical Population. Surgeon.
Function in Aortic Stenosis: A Study Using Speckle
2013;11(3):169-76.
Tracking Echocardiography. Echocardiography.
489. Valentijn TM, Hoeks SE, Martienus KA, Bakker EJ,
2013;30(3):293-300.
Van De Luijtgaarden KM, Verhagen HJ, Stolker RJ,
495. Van De Luijtgaarden KM, Bakker EJ, Rouwet
Van Lier F. Impact of Haemoglobin Concentration
EV, Hoeks SE, Valentijn TM, Stolker RJ, Majoor-
on Cardiovascular Outcome after Vascular Surgery:
Krakauer D, Verhagen HJM. Aneurysmal Disease
A Retrospective Observational Cohort Study. Eur J
Is Associated with Lower Carotid Intima-Media
Anaesthesiol. 2013;30(11):664-70.
Thickness Than Occlusive Arterial Disease. J Vasc
490. Valk SDA, Dabiri-Abkenari L, Theuns DAMJ,
Thornton AS, Res JCJ, Jordaens L. Ventricular
Surg. 2013;57(3):642-7.
496. Van De Luijtgaarden KM, Bastos Gonçalves
Fibrillation and Life-Threatening Ventricular
F, Majoor-Krakauer D, Verhagen HJM. Arterial
Tachycardia in the Setting of Outflow Tract
Elongation and Tortuosity Leads to Detection of
Arrhythmias - the Place of Icd Therapy. Int J
a De Novo Tgfbr2 Mutation in a Young Patient
Cardiol. 2013;165(2):385-7.
with Complex Aortic Pathology. Eur Heart J.
491. Valk SDA, Theuns DAMJ, Jordaens L. Long-Term
Performance of the St Jude Riata 1580-1582
2013;34(15):1133.
497. van de Luijtgaarden KM, Bastos Goncalves F,
Icd Lead Family. Netherlands Heart Journal.
Rouwet EV, Hendriks JM, Ten Raa S, Verhagen HJ.
2013;21(3):127-34.
Conservative Management of Persistent Aortocaval
492. van Blijderveen JC, Verhamme KM, Zietse R,
Fistula after Endovascular Aortic Repair. J Vasc
Visser LE, Romio SA, Buhre PN, Sturkenboom
MC, Hofman A, Straus SM, Stricker BH.
Surg. 2013;58(4):1080-3.
498. van den Akker EK, Hesselink DA, Manintveld OC,
Overanticoagulation Is Associated with Renal
Dor FJ. Response to “Renal Postconditioning...
Function Decline. Journal of Nephrology.
Pause for Thought?”. Transplantation.
2013;26(4):691-8.
493. Van Boven N, Bogaard K, Ruiter J, Kimman
2013;96(7):e53-4.
499. van den Akker EK, Manintveld OC, Hesselink DA,
G, Theuns D, Kardys I, Umans V. Functional
de Bruin RW, IJzermans JN, Dor FJ. Protection
156
against Renal Ischemia-Reperfusion Injury by
506. Van Den Oord SCH, Ten Kate GL, Akkus Z,
Ischemic Postconditioning. Transplantation.
Renaud G, Sijbrands EJG, Ten Cate FJ, Van
2013;95(11):1299-305.
Der Lugt A, Bosch JG, De Jong N, Van Der
500. van den Akker JP, Egal M, Groeneveld JA.
Steen AFW, Schinkel AFL. Assessment of
Invasive Mechanical Ventilation as a Risk Factor
Subclinical Atherosclerosis Using Contrast-
for Acute Kidney Injury in the Critically Ill: A
Enhanced Ultrasound. European Heart Journal
Systematic Review and Meta-Analysis. Crit Care.
Cardiovascular Imaging. 2013;14(1):56-61.
507. Van Den Oord SCH, Ten Kate GL, Sijbrands
2013;17(3):R98.
501. Van Den Heuvel M, Van Esch JHM, Danser
EJG, Van Der Steen AFW, Schinkel AFL. Effect
AHJ. On the Origin of Urinary Angiotensin Ii.
of Carotid Plaque Screening Using Contrast-
Hypertension. 2010;56(4).
Enhanced Ultrasound on Cardiovascular Risk
502. Van Den Meiracker AH, Danser AHJ. Combination
Stratification. Am J Cardiol. 2013;111(5):754-9.
Therapy for Hypertension. Combinatietherapie
508. Van Der Bom T, Winter MM, Bouma BJ, Groenink
bij hypertensie. Ned Tijdschrift Geneesk
M, Vliegen HW, Pieper PG, Van Dijk APJ,
2013;157(44).
Sieswerda GT, Roos-Hesselink JW, Zwinderman
503. Van Den Oord SCH, Akkus Z, Roeters van Lennep
AH, Mulder BJM. Effect of Valsartan on Systemic
JE, Bosch JG, Van Der Steen AFW, Sijbrands
Right Ventricular Function: A Double-Blind,
EJG, Schinkel AFL. Assessment of Subclinical
Randomized, Placebo-Controlled Pilot Trial.
Atherosclerosis and Intraplaque Neovascularization
Circulation. 2013;127(3):322-30.
Using Quantitative Contrast-Enhanced Ultrasound
509. Van Der Bom T, Winter MM, Groenink M, Vliegen
in Patients with Familial Hypercholesterolemia.
HW, Pieper PG, Van Dijk APJ, Sieswerda GT,
Roos-Hesselink JW, Zwinderman AH, Mulder BJM,
504. Van Den Oord SCH, Renaud G, Bosch JG, De
Bouma BJ. Right Ventricular End-Diastolic Volume
Jong N, Van Der Steen AFW, Schinkel AFL. Far
Combined with Peak Systolic Blood Pressure
Wall Pseudo-Enhancement: A Neglected Artifact
During Exercise Identifies Patients at Risk for
in Carotid Contrast-Enhanced Ultrasound?
Complications in Adults with a Systemic Right
Ventricle. J Am Coll Cardiol. 2013;62(10):926-36.
505. van den Oord SCH, Sijbrands EJG, ten Kate
510. van der Boon RM, Marcheix B, Tchetche D, Chieffo
GL, van Klaveren D, van Domburg RT, van der
A, Van Mieghem NM, Dumonteil N, Vahdat O,
Steen AFW, Schinkel AFL. Carotid Intima-Media
Maisano F, Serruys PW, Kappetein AP, Fajadet J,
Thickness for Cardiovascular Risk Assessment:
Colombo A, Carrie D, van Domburg RT, de Jaegere
Systematic Review and Meta-Analysis.
PP. Transapical Versus Transfemoral Aortic Valve
Implantation: A Multicenter Collaborative Study.
157
in Young Adults: Predictors for Rate of Progression
Ann Thorac Surg. 2014;97(1):22-8.
511. van der Boon RM, Nuis RJ, Benitez LM, Van
of Stenosis and Aortic Dilatation. Int J Cardiol.
Mieghem NM, Perez S, Cruz L, van Geuns
RJ, Serruys PW, van Domburg RT, Dager AE,
2013;168(2):863-70.
516. Van Der Linde D, Bekkers JA, Mattace-Raso FUS,
de Jaegere PP. Frequency, Determinants and
Van De Laar IMBH, Moelker A, Van Den Bosch AE,
Prognostic Implications of Infectious Complications
Van Dalen BM, Timmermans J, Bertoli-Avella AM,
after Transcatheter Aortic Valve Implantation. Am J
Wessels MW, Bogers AJJC, Roos-Hesselink JW.
Cardiol. 2013;112(1):104-10.
Progression Rate and Early Surgical Experience
512. Van Der Boon RMA, Chieffo A, Dumonteil N,
in the New Aggressive Aneurysms-Osteoarthritis
Tchetche D, Van Mieghem NM, Buchanan GL,
Vahdat O, Marcheix B, Serruys PW, Fajadet
Syndrome. Ann Thorac Surg. 2013;95(2):563-9.
517. Van Der Linde D, Roos-Hesselink JW, Rizopoulos
J, Colombo A, Carrié D, Van Domburg RT, De
D, Heuvelman HJ, Budts W, Van Dijk APJ,
Jaegere PPT. Effect of Body Mass Index on Short-
Witsenburg M, Yap SC, Oxenius A, Silversides
and Long-Term Outcomes after Transcatheter
CK, Oechslin EN, Bogers AJJC, Takkenberg
Aortic Valve Implantation. Am J Cardiol.
JJM. Surgical Outcome of Discrete Subaortic
2013;111(2):231-6.
Stenosis in Adults a Multicenter Study. Circulation.
513. Van Der Boon RMA, Van Mieghem NM,
Theuns DA, Nuis RJ, Nauta ST, Serruys PW,
2013;127(11):1184-91.
518. Van Der Linde D, Rossi A, Yap SC, McGhie JS,
Jordaens L, Van Domburg RT, De Jaegere PPT.
Van Den Bosch AE, Kirschbaum SWM, Russo
Pacemaker Dependency after Transcatheter
B, Van Dijk APJ, Moelker A, Krestin GP, Van
Aortic Valve Implantation with the Self-Expanding
Geuns RJM, Roos-Hesselink JW. Ascending
Medtronic Core Valve System. Int J Cardiol.
Aortic Diameters in Congenital Aortic Stenosis:
2013;168(2):1269-73.
Cardiac Magnetic Resonance Versus Transthoracic
514. Van Der Heiden K, Gijsen FJH, Narracott A, Hsiao
Echocardiography. Echocardiography.
S, Halliday I, Gunn J, Wentzel JJ, Evans PC. The
Effects of Stenting on Shear Stress: Relevance
2013;30(5):497-504.
519. Van Der Linde D, Takkenberg JJM, Rizopoulos D,
to Endothelial Injury and Repair. Cardiovasc Res.
Heuvelman HJ, Budts W, Van Dijk APJ, Witsenburg
2013;99(2):269-75.
M, Yap SC, Bogers AJJC, Silversides CK, Oechslin
515. Van Der Linde D, Andrinopoulou ER, Oechslin
EN, Roos-Hesselink JW. Natural History of
EN, Budts W, Van Dijk APJ, Pieper PG, Wajon
Discrete Subaortic Stenosis in Adults: A Multicentre
EMCJ, Post MC, Witsenburg M, Silversides CK,
Study. Eur Heart J. 2013;34(21):1548-56.
Oxenius A, Bogers AJJC, Takkenberg JJM, Roos-
520. Van Der Linde D, Van De Laar IMBH, Moelker A,
Hesselink JW. Congenital Valvular Aortic Stenosis
Wessels MW, Bertoli-Avella AM, Roos-Hesselink
158
JW. Patients with Aneurysms and Osteoarthritis:
526. Van Dijk SC, Smulders YM, Enneman AW, Swart
Marfan Syndrome Ruled out, So What Is It?
KMA, Van Wijngaarden JP, Ham AC, Van Schoor
Patiënten met aneurysmata en osteoartritis:
NM, Dhonukshe-Rutten RAM, De Groot LCPGM,
Geen syndroom van Marfan, maar wat dan? Ned
Lips P, Uitterlinden AG, Blom HJ, Geleijnse JM,
Tijdschrift Geneeskd.2013;157(21): A5588.
Feskens EJ, Van Den Meiracker AH, Raso FM, Van
521. van der Lubbe N, Moes AD, Rosenbaek LL,
Der Velde N. Homocysteine Level Is Associated
Schoep S, Meima ME, Danser AHJ, Fenton RA,
with Aortic Stiffness in Elderly: Cross-Sectional
Zietse R, Hoorn EJ. K+-Induced Natriuresis Is
Results from the B-Proof Study. J Hypertens.
Preserved During Na+ Depletion and Accompanied
2013;31(5):952-9.
by Inhibition of the Na+-Cl- Cotransporter.
527. van Engelen K, Postma AV, van de Meerakker JBA,
American Journal of Physiology - Renal Physiology.
Roos-Hesselink JW, Helderman-Van den Enden
2013;305(8):F1177-F88.
ATJM, Vliegen HW, Rahman T, Baars MJH, Sels
522. Van Der Lubbe N, Zietse R, Hoorn EJ. Effects of
JW, Bauer U, Pickardt T, Sperling SR, Moorman
Angiotensin Ii on Kinase-Mediated Sodium and
AFM, Keavney B, Goodship J, Klaassen S, Mulder
Potassium Transport in the Distal Nephron. Curr
BJM. Ebstein’s Anomaly May Be Caused by
Opin Nephrol Hypertens. 2013;22(1):120-6.
Mutations in the Sarcomere Protein Gene Myh7.
523. Van Der Pas R, Leebeek FWG, Hofland LJ, De
Herder WW, Feelders RA. Hypercoagulability in
528. van Geldorp MWA, Heuvelman HJ, Kappetein AP,
Cushing’s Syndrome: Prevalence, Pathogenesis
Busschbach JJV, Cohen DJ, Takkenberg JJM,
and Treatment. Clin Endocrinol (Oxf).
Bogers AJJC. Quality of Life among Patients with
2013;78(4):481-8.
Severe Aortic Stenosis. Netherlands Heart Journal.
524. van der Weerd K, Dik WA, Schrijver B, Bogers
2013;21(1):21-7.
AJJC, Maat APWM, van Nederveen FH, van
529. van Geldorp MWA, Heuvelman HJ, Kappetein
Hagen PM, van Dongen JJM, Langerak AW,
AP, Busschbach JJV, Takkenberg JJM, Bogers
Staal FJT. Combined Tcrg and Tcra Trec Analysis
AJJC. The Effect of Aortic Valve Replacement
Reveals Increased Peripheral T-Lymphocyte but
on Quality of Life in Symptomatic Patients with
Constant Intra-Thymic Proliferative History Upon
Severe Aortic Stenosis. Netherlands Heart Journal.
Ageing. Mol Immunol. 2013;53(3):302-12.
2013;21(1):28-35.
525. van der Wiel AM, Janssen M, Hollack C,
530. Van Genderen ME, Bartels SA, Lima A, Bezemer
Langendonk JG. [Complications Due to Receiving
R, Ince C, Bakker J, Van Bommel J. Peripheral
Incorrect Amino Acid Preparations] Complicaties
Perfusion Index as an Early Predictor for Central
Door Verwisseling Aminozuurpreparaten. Ned
Hypovolemia in Awake Healthy Volunteers. Anesth
Tijdschr Geneeskd. 2013;157(3):A5183.
Analg. 2013;116(2):351-6.
159
531. Van Genderen ME, Lima A, Bakker J, Van Bommel
J. Peripheral Circulation in Critically Ill Patients:
2013;305(12):H1790-H7.
537. Van Laanen JHH, Hendriks JM, Verhagen HJM,
Non-Invasive Methods for the Assessment of
Van Beusekom HMM. Quantity, Particle Size,
the Peripheral Perfusion. Perifere circulatie bij
and Histologic Composition of Embolic Debris
ernstig zieke patiënten: Non-invasieve methoden
Collected in a Distal Protection Filter after Carotid
voor beoordeling van de perifere perfusie. Ned
Angioplasty and Stenting: Correlation with Patient
Tijdschrift Geneesk 2013;157: A5338
Characteristics, Timing of Carotid Artery Stenting,
532. van Gils MJ, Bodde MC, Cremers LGM, Dippel
and Procedural Details. J Thorac Cardiovasc Surg.
DWJ, Van der Lugt A. Determinants of Calcification
Growth in Atherosclerotic Carotid Arteries; a
2013;146(2):492-5.
538. Van Leeuwen MAH, Daemen J, Van Mieghem NM,
Serial Multi-Detector Ct Angiography Study.
De Boer SPM, Boersma E, Van Geuns RJ, Zijlstra
F, Van Domburg RT, Serruys PWJC. Comparison
533. van Haperen R, van Gent T, van Tol A, de Crom
of Long-Term Outcomes in Stemi and Nste-Acs
R. Elevated Expression of Pltp Is Atherogenic in
after Coronary Stent Placement: An Analysis in a
Apolipoprotein E Deficient Mice. Atherosclerosis.
Real World Bms and Des Population. Int J Cardiol.
2013;227(1):37-42.
2013;167(5):2082-7.
534. Van Hellemond JJ, Van Domburg RT, Caliskan K,
539. Van Leeuwen WJ, Head SJ, De Groot-De Laat
Birim O, Balk AH. Toxoplasma Gondii Serostatus Is
LE, Geleijnse ML, Bogers AJJC, Van Herwerden
Not Associated with Impaired Long-Term Survival
LA, Kappetein AP. Single-Centre Experience
after Heart Transplantation. Transplantation.
with Mitral Valve Repair in Asymptomatic
2013;96(12):1052-8.
Patients with Severe Mitral Valve Regurgitation.
535. Van Hout GPJ, De Jong R, Vrijenhoek JEP,
Interactive Cardiovascular and Thoracic Surgery.
Timmers L, Duckers HJ, Hoefer IE. AdmittanceBased Pressure-Volume Loop Measurements in
2013;16(6):731-7.
540. Van Mieghem NM, Chieffo A, Dumonteil N, Tchetche
a Porcine Model of Chronic Myocardial Infarction.
D, Van Der Boon RMA, Buchanan GL, Marcheix
Exp Physiol. 2013;98(11):1565-75.
B, Vahdat O, Serruys PW, Fajadet J, Carrié D,
536. van Houwelingen MJ, Merkus D, Hofland J,
Colombo A, De Jaegere PPT. Trends in Outcome
Bakker J, Tenbrinck R, te Lintel Hekkert M,
after Transfemoral Transcatheter Aortic Valve
van Dijk G, Hoeks APG, Duncker DJ. A Novel
Approach to Assess Hemorrhagic Shock Severity
Implantation. Am Heart J. 2013;165(2):183-92.
541. Van Mieghem NM, De Jaegere PP. Intravascular
Using the Arterially Determined Left Ventricular
Ultrasound-Guided Stenting of Left Main Stem
Isovolumic Contraction Period. American Journal
Dissection after Medtronic Corevalve Implantation.
of Physiology - Heart and Circulatory Physiology.
Catheter Cardiovasc Interv. 2013;82(2):240-4.
160
542. Van Mieghem NM, Schipper ME, Ladich E, Faqiri
Coronary Artery Dissection: Potential Cause
E, van der Boon R, Randjgari A, Schultz C, Moelker
of Sudden Death in Soccer. Circulation.
A, van Geuns RJ, Otsuka F, Serruys PW, Virmani
2013;127(3):e280-e2.
R, de Jaegere PP. Response to Letter Regarding
548. van Nierop BJ, van Assen HC, van Deel ED,
Article, “Histopathology of Embolic Debris Captured
Niesen LB, Duncker DJ, Strijkers GJ, Nicolay K.
During Transcatheter Aortic Valve Replacement”.
Phenotyping of Left and Right Ventricular Function
Circulation. 2013;128(25):e478-9.
in Mouse Models of Compensated Hypertrophy
543. Van Mieghem NM, Schipper MEI, Ladich E,
and Heart Failure with Cardiac Mri. PLoS One.
Faqiri E, Van Der Boon R, Randjgari A, Schultz
2013;8(2):e55424.
C, Moelker A, Van Geuns RJ, Otsuka F, Serruys
549. Van Noord D, Sana A, Moons LM, Pattynama
PW, Virmani R, De Jaegere PP. Histopathology
PM, Verhagen HJ, Kuipers EJ, Mensink
of Embolic Debris Captured During Transcatheter
PB. Combining Radiological Imaging and
Aortic Valve Replacement. Circulation.
Gastrointestinal Tonometry: A Minimal Invasive
2013;127(22):2194-201.
and Useful Approach for the Workup of Chronic
544. Van Mieghem NM, Serruys PW. The Art
Gastrointestinal Ischemia. Eur J Gastroenterol
of Risk Stratification in Tavi. Eur Heart J.
Hepatol. 2013;25(6):719-25.
550. van Saet A, de Wildt SN, Knibbe CA, Bogers
2013;34(25):1859-61.
545. Van Mieghem NM, Van Der Boon RM. Porcelain
AD, Stolker RJ, Tibboel D. The Effect of Adult
Aorta and Severe Aortic Stenosis: Is Transcatheter
and Pediatric Cardiopulmonary Bypass on
Aortic Valve Implantation the New Standard? Aorta
Pharmacokinetic and Pharmacodynamic
De Porcelana Y Estenosis Aortica Grave: Inverted
Parameters. Curr Clin Pharmacol. 2013;8(4):297-
Question Markla Implantacion Percutanea De
318.
Valvula Aortica Es El Nuevo Tratamiento Estandar?
551. Van Tiel J, Bron EE, Tiderius CJ, Bos PK, Reijman
M, Klein S, Verhaar JAN, Krestin GP, Weinans H,
Rev Esp Cardiol. 2013;66(10):765-7.
546. Van Mieghem NM, Van Der Boon RM, Faqiri E,
Kotek G, Oei EHG. Reproducibility of 3d Delayed
Diletti R, Schultz C, Van Geuns RJ, Serruys PW,
Gadolinium Enhanced Mri of Cartilage (Dgemric)
Kappetein AP, Van Domburg RT, De Jaegere PP.
of the Knee at 3.0 T in Patients with Early Stage
Complete Revascularization Is Not a Prerequisite
Osteoarthritis. Eur Radiol. 2013;23(2):496-504.
for Success in Current Transcatheter Aortic Valve
552. van Velsen EFS, Vernooij MW, Vrooman HA, van
Implantation Practice. JACC: Cardiovascular
der Lugt A, Breteler MMB, Hofman A, Niessen WJ,
Ikram MA. Brain Cortical Thickness in the General
547. Van Mieghem NM, Van Weenen S, Nollen G,
Elderly Population: The Rotterdam Scan Study.
Ligthart J, Regar E, Van Geuns RJ. Traumatic
Neurosci Lett. 2013;550:189-94.
161
553. Van Zeggeren L, Bastos Gonçalves F, Van
559. Verhaaren BFJ, Vernooij MW, Koudstaal PJ,
Herwaarden JA, Zandvoort HJA, Werson
Uitterlinden AG, Van Duijn CM, Hofman A, Breteler
DAB, Vos JA, Moll FL, Verhagen HJ, De Vries
MMB, Ikram MA. Alzheimer’s Disease Genes and
JPPM. Incidence and Treatment Results of
Cognition in the Nondemented General Population.
Endurant Endograft Occlusion. J Vasc Surg.
Biol Psychiatry. 2013;73(5):429-34.
560. Verheugt FWA, Clemmensen P, Mehran R, Agewall
2013;57(5):1246-54.
554. Vandergheynst F, Sakr Y, Felleiter P, Hering
S, Pocock SJ, Goldstein S, Torp-Pedersen C,
R, Groeneveld J, Vanhems P, Taccone FS,
Simoons ML, Borer JS, Khder YM, Burton P,
Vincent JL. Incidence and Prognosis of
Deliargyris E, McMurray JJV, Berkowitz SD, Stough
Dysnatraemia in Critically Ill Patients: Analysis
WG, Zannad F. Antithrombotic Outcome Trials in
of a Large Prevalence Study. Eur J Clin Invest.
Acute Coronary Syndromes: Seeking the Optimal
2013;43(9):933-48.
Balance between Safety and Efficacy. Eur Heart J.
555. Verberkmoes NJ, Mokhles MM, Bramer S,
2013;34(22):1621-9.
Van Straten AH, Ter Woorst JF, Maessen JG,
561. Verlinden VJA, Van der Geest JN, Hoogendam YY,
Berreklouw E. Clinical Outcome of the Pas-Port(R)
Hofman A, Breteler MMB, Ikram MA. Gait Patterns
Proximal Anastomosis System in Off-Pump
in a Community-Dwelling Population Aged 50 Years
Coronary Artery Bypass Grafting in 201 Patients. J
and Older. Gait Posture. 2013;37(4):500-5.
562. Versteylen MO, Kietselaer BL, Dagnelie PC,
Cardiovasc Surg (Torino). 2013;54(3):389-95.
556. Verdonk K, Visser W, Van Den Meiracker
Joosen IA, Dedic A, Raaijmakers RH, Wildberger
AH, Danser AHJ. Are Aldosterone
JE, Nieman K, Crijns HJ, Niessen WJ, Daemen
Levels Inappropriately Low in
MJ, Hofstra L. Additive Value of Semiautomated
Preeclampsia? Hypertension. 2013;62(5):e39.
Quantification of Coronary Artery Disease Using
557. Verhaaren BFJ, Vernooij MW, De Boer R, Hofman
Cardiac Computed Tomographic Angiography to
A, Niessen WJ, Van Der Lugt A, Ikram MA.
Predict Future Acute Coronary Syndrome. J Am
High Blood Pressure and Cerebral White Matter
Coll Cardiol. 2013;61(22):2296-305.
Lesion Progression in the General Population.
563. Vlot J, Wijnen R, Stolker RJ, Bax K. Optimizing
Working Space in Porcine Laparoscopy: Ct
Hypertension. 2013;61(6):1354-9.
558. Verhaaren BFJ, Vernooij MW, Dehghan A,
Measurement of the Effects of Intra-Abdominal
Vrooman HA, De Boer R, Hofman A, Witteman
Pressure. Surgical Endoscopy and Other
JCM, Niessen WJ, Breteler MMB, Van Der Lugt
Interventional Techniques. 2013;27(5):1668-73.
A, Ikram MA. The Relation of Uric Acid to Brain
564. Vranckx P, McFadden E, Cutlip DE, Mehran R,
Atrophy and Cognition: The Rotterdam Scan Study.
Swart M, Kint PP, Zijlstra F, Silber S, Windecker
Neuroepidemiology. 2013;41(1):29-34.
S, Serruys PWCJ. Clinical Endpoint Adjudication
162
in a Contemporary All-Comers Coronary Stent
R, Van Domburg RT, Schinkel AFL. Prediction
Investigation: Methodology and External Validation.
of 8-Year Cardiovascular Outcomes in Patients
Contemporary Clinical Trials. 2013;34(1):53-9.
with Systemic Arterial Hypertension: Value of
565. Vranckx P, Verheugt FWA, De Maat MP, Ulmans
Stress 99mtc-Tetrofosmin Myocardial Perfusion
VAWM, Regar E, Smits P, Ten Berg JM, Lindeboom
Imaging in a High-Risk Cohort. J Nucl Cardiol.
W, Jones RL, Friedman J, Reilly P, Leebeek
2013;20(6):1030-40.
FWG. A Randomised Study of Dabigatran in
570. Wang T, Wieser W, Springeling G, Beurskens R,
Elective Percutaneous Coronary Intervention
Lancee CT, Pfeiffer T, Van Der Steen AFW, Huber
in Stable Coronary Artery Disease Patients.
R, Van Soest G. Intravascular Optical Coherence
Tomography Imaging at 3200 Frames Per Second.
566. Vriesendorp PA, Schinkel AFL, Van Cleemput J,
Willems R, Jordaens LJLM, Theuns DAMJ, Van
Optics Letters. 2013;38(10):1715-7.
571. Wardlaw JM, Smith EE, Biessels GJ, Cordonnier
Slegtenhorst MA, De Ravel TJ, Ten Cate FJ,
C, Fazekas F, Frayne R, Lindley RI, O’Brien JT,
Michels M. Implantable Cardioverter-Defibrillators
Barkhof F, Benavente OR, Black SE, Brayne C,
in Hypertrophic Cardiomyopathy: Patient
Breteler M, Chabriat H, DeCarli C, de Leeuw
Outcomes, Rate of Appropriate and Inappropriate
FE, Doubal F, Duering M, Fox NC, Greenberg S,
Interventions, and Complications. Am Heart J.
Hachinski V, Kilimann I, Mok V, Oostenbrugge
2013;166(3):496-502.
RV, Pantoni L, Speck O, Stephan BCM, Teipel S,
567. Vriesendorp PA, Van Mieghem NM, Vletter WB,
Viswanathan A, Werring D, Chen C, Smith C, van
Ten Cate FJ, de Jong PL, Schinkel AFL, Michels
Buchem M, Norrving B, Gorelick PB, Dichgans M.
M. Microsphere Embolisation as an Alternative
Neuroimaging Standards for Research into Small
for Alcohol in Percutaneous Transluminal Septal
Vessel Disease and Its Contribution to Ageing
Myocardial Ablation. Netherlands Heart Journal.
and Neurodegeneration. The Lancet Neurology.
2013;21(5):245-8.
568. Wagenaar GTM, Laghmani EH, Fidder M, Sengers
2013;12(8):822-38.
572. White T, Marroun HE, Nijs I, Schmidt M, Van
RMA, de Visser YP, de Vries L, Rink R, Roks AJM,
Der Lugt A, Wielopolki PA, Jaddoe VWV,
Folkerts G, Walther FJ. Agonists of Mas Oncogene
Hofman A, Krestin GP, Tiemeier H, Verhulst FC.
and Angiotensin Ii Type 2 Receptors Attenuate
Pediatric Population-Based Neuroimaging and
Cardiopulmonary Disease in Rats with Neonatal
the Generation R Study: The Intersection of
Hyperoxia-Induced Lung Injury. American Journal
Developmental Neuroscience and Epidemiology.
of Physiology - Lung Cellular and Molecular
Physiology. 2013;305(5):L341-L51.
Eur J Epidemiol. 2013;28(1):99-111.
573. Widimsky P, Motovska Z, Belardi J, Serruys P,
569. Wai MCGTJ, Ottenhof MJM, Boiten HJ, Valkema
Silber S, Windecker S, Neumann FJ. Long-Term
163
Outcomes of Patients Receiving Zotarolimus-
G, Dimitriou M, Doney ASF, Döring A, Elliott P,
Eluting Stents in St Elevation Myocardial Infarction,
Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi
Non-St Elevation Acute Coronary Syndrome, and
MO, Grallert H, Gravito ML, Groves CJ, Hallmans
Stable Angina: Data from the Resolute Program. Int
G, Hartikainen AL, Hayward C, Hernandez D,
J Cardiol. 2013;168(4):3522-6.
Hicks AA, Holm H, Hung YJ, Illig T, Jones MR,
574. Wieringa WG, Lexis CPH, Diercks GFH, Lipsic
Kaleebu P, Kastelein JJP, Khaw KT, Kim E, Klopp
E, Tan ES, Schurer RAJ, Van Der Werf HW,
N, Komulainen P, Kumari M, Langenberg C,
Van Den Heuvel AFM, Suurmeijer AJH, Zijlstra
Lehtimäki T, Lin SY, Lindström J, Loos RJF, Mach
F, De Smet BJGL, Pundziute G. The Feasibility
F, McArdle WL, Meisinger C, Mitchell BD, Müller
of Optical Coherence Tomography Guided
G, Nagaraja R, Narisu N, Nieminen TVM, Nsubuga
Thrombus Aspiration in Patients with Non-
RN, Olafsson I, Ong KK, Palotie A, Papamarkou
St-Elevation Myocardial Infarction after Initial
T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker
Conservative Therapy - a Pilot Study. Int J Cardiol.
PM, Rivadeneira F, Rudan I, Ruokonen A, Samani
2013;168(5):4981-2.
N, Scharnagl H, Seeley J, Silander K, Stancáková
575. Willer CJ, Schmidt EM, Sengupta S, Peloso
A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, Van
GM, Gustafsson S, Kanoni S, Ganna A, Chen J,
Pelt LJ, Vedantam S, Wainwright N, Wijmenga C,
Buchkovich ML, Mora S, Beckmann JS, Bragg-
Wild SH, Willemsen G, Wilsgaard T, Wilson JF,
Gresham JL, Chang HY, Demirkan A, Den Hertog
Young EH, Zhao JH, Adair LS, Arveiler D, Assimes
HM, Do R, Donnelly LA, Ehret GB, Esko T,
TL, Bandinelli S, Bennett F, Bochud M, Boehm BO,
Feitosa MF, Ferreira T, Fischer K, Fontanillas P,
Boomsma DI, Borecki IB, Bornstein SR, Bovet P,
Fraser RM, Freitag DF, Gurdasani D, Heikkilä K,
Burnier M, Campbell H, Chakravarti A, Chambers
Hyppönen E, Isaacs A, Jackson AU, Johansson Å,
JC, Chen YDI, Collins FS, Cooper RS, Danesh J,
Johnson T, Kaakinen M, Kettunen J, Kleber ME,
Dedoussis G, De Faire U, Feranil AB, Ferrières
Li X, Luan J, Lyytikäinen LP, Magnusson PKE,
J, Ferrucci L, Freimer NB, Gieger C, Groop LC,
Mangino M, Mihailov E, Montasser ME, Müller-
Gudnason V, Gyllensten U, Hamsten A, Harris TB,
Nurasyid M, Nolte IM, O’Connell JR, Palmer CD,
Hingorani A, Hirschhorn JN, Hofman A, Hovingh
Perola M, Petersen AK, Sanna S, Saxena R,
GK, Hsiung CA, Humphries SE, Hunt SC, Hveem
Service SK, Shah S, Shungin D, Sidore C, Song
K, Iribarren C, Järvelin MR, Jula A, Kähönen M,
C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich
Kaprio J, Kesäniemi A, Kivimaki M, Kooner JS,
TM, Thorleifsson G, Van Den Herik EG, Voight
Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J,
BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W,
Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren
Absher D, Asiki G, Barroso I, Been LF, Bolton JL,
CM, Martin NG, März W, McCarthy MI, McKenzie
Bonnycastle LL, Brambilla P, Burnett MS, Cesana
CA, Meneton P, Metspalu A, Moilanen L, Morris
164
AD, Munroe PB, Njølstad I, Pedersen NL, Power C,
Link to Idiopathic Ventricular Fibrillation. Circ Res.
Pramstaller PP, Price JF, Psaty BM, Quertermous
2013;112(10):1310-22.
T, Rauramaa R, Saleheen D, Salomaa V,
579. Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E,
Sanghera DK, Saramies J, Schwarz PEH, Sheu
Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen
WHH, Shuldiner AR, Siegbahn A, Spector TD,
S, Jukema JW, Krams R, Kwak BR, Marx N,
Stefansson K, Strachan DP, Tayo BO, Tremoli
Naruszewicz M, Newby A, Pasterkamp G, Serruys
E, Tuomilehto J, Uusitupa M, Van Duijn CM,
PWJC, Waltenberger J, Weber C, Tokgözoglu L.
Vollenweider P, Wallentin L, Wareham NJ, Whitfield
Stabilization of Atherosclerotic Plaques: An Update.
JB, Wolffenbuttel BHR, Ordovas JM, Boerwinkle
E, Palmer CNA, Thorsteinsdottir U, Chasman
Eur Heart J. 2013;34(42):3251-8.
580. Younge JO, Damen NL, Van Domburg RT,
DI, Rotter JI, Franks PW, Ripatti S, Cupples LA,
Pedersen SS. Obesity, Health Status, and 7-Year
Sandhu MS, Rich SS, Boehnke M, Deloukas P,
Mortality in Percutaneous Coronary Intervention: In
Kathiresan S, Mohlke KL, Ingelsson E, Abecasis
Search of an Explanation for the Obesity Paradox.
GR. Discovery and Refinement of Loci Associated
Int J Cardiol. 2013;167(4):1154-8.
with Lipid Levels. Nat Genet. 2013;45(11):1274-85.
581. Zelensky AN, Sanchez H, Ristic D, Vidic I,
576. Wilson JH, Sinaasappel M, Lotgering FK,
Van Rossum-Fikkert SE, Essers J, Wyman C,
Langendonk JG. Recommendations for
Kanaar R. Caffeine Suppresses Homologous
Pregnancies in Patients with Crigler-Najjar
Recombination through Interference with Rad51-
Syndrome. JIMD Rep. 2013;7:59-62.
Mediated Joint Molecule Formation. Nucleic Acids
577. Winkel LC, Groen HC, van Thiel BS, Muller C,
van der Steen AF, Wentzel JJ, de Jong M, Van der
Res. 2013;41(13):6475-89.
582. Zhang J, Goode KM, Rigby A, Balk AHMM,
Heiden K. Folate Receptor-Targeted Single-Photon
Cleland JG. Identifying Patients at Risk of Death
Emission Computed Tomography/Computed
or Hospitalisation Due to Worsening Heart Failure
Tomography to Detect Activated Macrophages
Using Decision Tree Analysis: Evidence from the
in Atherosclerosis: Can It Distinguish Vulnerable
Trans-European Network-Home-Care Management
from Stable Atherosclerotic Plaques? Mol Imaging.
System (Ten-Hms) Study. Int J Cardiol.
2013;12(0):1-5.
2013;163(2):149-56.
578. Xiao L, Koopmann TT, Ördög B, Postema PG,
583. Zhang Y, Bourantas CV, Farooq V, Muramatsu T,
Verkerk AO, Iyer V, Sampson KJ, Boink GJJ,
Diletti R, Onuma Y, Garcia-Garcia HM, Serruys
Mamarbachi MA, Varro A, Jordaens L, Res J,
PW. Bioresorbable Scaffolds in the Treatment
Kass RS, Wilde AA, Bezzina CR, Nattel S. Unique
of Coronary Artery Disease. Medical Devices
Cardiac Purkinje Fiber Transient Outward Current
(Auckland) 2013;6(1):37-48.
Β-Subunit Composition: A Potential Molecular
584. Zhang YJ, Garcia-Garcia HM, Farooq V, Bourantas
165
CV, Serruys PW, Chen SL. Revisiting: “Comparison
of Intravascular Ultrasound Versus AngiographyGuided Drug-Eluting Stent Implantation: A
Meta-Analysis of One Randomised Trial and Ten
Observational Studies Involving 19,619 Patients”.
585. Zhang YJ, Xu B, Serruys PW, Bourantas CV,
Iqbal J, Muramatsu T, Li MH, Ye F, Tian NL,
Garcia-Garcia HM, Chen SL. Radial Approach for
Patients with St-Segment Elevation Acute Coronary
Syndrome: It Is Definitely the Best Access Site. Int
J Cardiol. 2013;168(3):3140-2.
586. Zhou Z, De Wijs-Meijler D, Lankhuizen I, Jankowski
J, Jankowski V, Jan Danser AH, Duncker DJ,
Merkus D. Blunted Coronary Vasodilator Response
to Uridine Adenosine Tetraphosphate in Post-Infarct
Remodeled Myocardium Is Due to Reduced P1
Receptor Activation. Pharmacol Res. 2013;77:22-9.
587. Zhou Z, Merkus D, Cheng C, Duckers HJ,
Danser AH, Duncker DJ. Uridine Adenosine
Tetraphosphate Is a Novel Vasodilator in the
Coronary Microcirculation Which Acts through
Purinergic P1 but Not P2 Receptors. Pharmacol
Res. 2013;67(1):10-7.
588. Zijlstra F, van Geuns RJ. Revised Nhg Practice
Guideline ‘Acute Coronary Syndrome’: A Strong
Link in the Chain of Treatment. Herziene NhgStandaard ‘Acuut Coronair Syndroom’: Een Sterke
Schakel in De Behandelketen. Ned Tijdschr
Geneeskd. 2013;157(8):A5930.
166
167
Edited by: Erna Egelie
Photography: Levien Willemse
Lay out: Maud van Nierop
Production and publication: COEUR Secretariat, Erasmus MC
Printing: Mediajoenit BV, Rotterdam
Contact:
Thoraxcentre
Erasmus MC
P.O. Box 2040
3000 CA Rotterdam
The Netherlands
Phone: +31-10-7035312
Email: [email protected]
Website: www.coeur.nl
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