P Putz microbio ws 3-4dec2015

Dr Peter Putz
Scientific project Manager, ILSI Europe
The Human Gut Microbiota
• An adult human body has about 10 times more
bacteria than human cells
• Humans and their microbiota have a symbiotic
relationship
• Influenced by medication, diet and lifestyle gut
microbiota composition changes throughout
development, which has effects on its host
physiology (adiposity, immune system, etc.)
Human Microbiota as Transversal
Topic for ILSI Europe Task Forces
Functional
Foods
Prebiotics
Metabolic
Imprinting
Probiotics
Nutrition
Immunity and
Inflammation
Obesity and
Diabetes
Nutrition and
Mental
Performance
Emerging
Microbiological Issues
Human Microbiota as Transversal
Topic for ILSI Europe Task Forces
Functional
Foods
Prebiotics
Metabolic
Imprinting
Probiotics
Nutrition
Immunity and
Inflammation
Obesity and
Diabetes
Nutrition and
Mental
Performance
Emerging
Microbiological Issues
Human Microbiota as Transversal
Topic for ILSI Europe Task Forces
• K.A. Verbeke, et al. Towards Microbial Fermentation
Metabolites as Markers for Health Benefits of
Prebiotics. Nutrition Research Reviews 2015;28:42–66.
• N. Binns. Probiotics, Prebiotics and the Gut Microbiota. ILSI
Europe Concise Monograph Series 2013;1-32.
• M. Roberfroid, et al. Prebiotic Effects: Metabolic and Health
Benefits. British Journal of Nutrition 2010;104(S2):S1-S63.
• J. Neu, Guest Editor. Guidance for Assessing the Probiotics
Beneficial Effects: How to Fill the GAP. Journal of Nutrition
2010;140:S671-S721.
Human Microbiota as Transversal
Topic for ILSI Europe Task Forces
• Expert group: Exploring the Role of the Major Gut
Microbiota Clusters on Nutritional and Functional
Benefits of Nutrients and Non-nutrients
• Expert group: Oral and systemic health resilience
Objectives of the Workshop
• Reviews of existing data on different gut microbiota
•
clusters and methodologies to assess the impact
on bioavailability of dietary components and energy
exploitation
• Two manuscripts drafted by a joint expert group
of the Functional Foods & Prebiotics Task
Forces
Paving the way for ILSI Europe’s future role in the
area of the human microbiota
8
EU Commission President Barroso
‘Only if the best brains from academia, industry,
SMEs, research institutes and other organisations
come together can we successfully tackle the
huge challenges that we are facing.’
Speaking July 2014 at the launch of a call for EUindustry partnership projects under Horizon 2020
funding
Who we are – Vision
We build multi-stakeholder science-based
solutions for a sustainable and healthier world.
What we do – Mission
We foster collaboration between relevant
stakeholders.
We identify existing and emerging
challenges in food, nutrition and health and
facilitate proactive practical solutions.
We communicate and disseminate our
scientific output widely.
Our way of working is designed to deliver
science of the highest quality and integrity.
Combining the best
Industry
Academia
Government
Combining the best
The best results can be achieved by
Industryscientific knowledge
Academiaand
combining
expertise from industry, academia and
government so that decisions affecting
public health and safety are based on
science.
Government
Cooperation: Academia,
Government and Industry
• Robust science and clear scientific solutions are
needed to solve today’s public health issues
• Combining the best scientific knowledge from
industry, academia and the public sector
produces the best results
Cooperation: Academia,
Government and Industry
• Robust science and clear scientific solutions are
needed to solve today’s public health issues
>400 peerWe publish the
reviewed
results ofthe
all our
• Combining
best scientific knowledge
from
publications
–
research
industry,
academia and the public
widelysector
accepted as
regardless
of results
produces
the best
a mark of scientific
outcome
quality.
ILSI Europe Key Principles
Scientific
Excellence
Tripartite
Nature /
Public-Private
Partnership
Public
Interest
Volunteering
Scientists
Non-Profit
Association
Emerging
Issues
ScienceDriven
Organisation
PeerReviewed
Publications
Scientific Leadership
H – Index 71
High
Performance
Stringent
Scientific
Review
Visibility
A network of highly renowned experts
• Collaboration with
240 non-industry experts
from 21 countries
worldwide
• Active network of
500 scientists
• Communication to
9,200 stakeholders
• Member of the ILSI family
Additional network
of ~ 550 scientists
through the EU
projects we are
involved in
Mapping of scientific activities
Mapping of scientific activities
An overview of gut physiology and
microbiome composition
Professor at the Laboratory of Microbial Ecology and
Technology at the University of Ghent, BE.
Scientific output of more than 100 peer-reviewed
publications. The gastrointestinal microbiological
expertise has resulted in the creation of a spin-off
company, ProDigest, which delivers service-based
research for the food, feed and pharmaceutical industry.
Prof. Tom van de Wiele
21
The Interaction of Gut Microbiota with
Dietary Components and its
Consequences for Metabolism
Leader of the Microbiology Group and of the Gut Health
Theme at the Rowett Institute of Nutrition and Health,
University of Aberdeen, UK.
Over the past 30 years spent at the Rowett Institute, his
research has focused on the impact of commensal and
symbiotic micro-organisms in the mammalian gut on
nutrition and health.
Prof. Harry Flint
22
Introduction of the Systematic Review
Manuscript
Physician specialized in internal medicine, with a PhD in
Nutrition. He worked for ten years as resident and
resident-in-chief in university hospitals in France before
joining Danone, in 1983 to create the Department of
Nutrition and implement clinical research on the effect of
food on humans. Actively involved in ILSI Europe since its
creation in 1986, he has contributed to many functional
food projects and more than 20 task forces.
Dr Jean-Michel Antoine
23
Introduction of the Systematic Review
Manuscript
Prior to joining the University of Reading in 2007 as the
Hugh Sinclair Professor of Human Nutrition, he was head
of nutrition at the University of Ulster. His main research
area is the interaction of diet, gut microbiota and health
with a particular focus on the metabolism of
phytochemicals and impact on health. He is on the
Thompson Reuters List of Most Highly Cited Researchers
2014.
Prof. Ian Rowland
24
Diet-microbiome-health Interactions in
Older People
Professor of Microbial Genomics at University College
Cork, Ireland following industry and academic positions
in Sweden, Canada, New Zealand and the United States.
His main research theme is the genomics of
gastrointestinal bacteria in humans with emphasis on
commensal species.
He has published over 150 articles and has an H-index of
39.
Prof. Paul O’Toole
25
Impact of Microbiome on Liver Disease
Leader of the Nutrition and Nutrigenomics Group at
Fondazione Edmund Mach, Trento, IT.
His research focuses on the health effects of diet,
microbe interactions in the gut and his group has
expertise in microbial ecology, dairy microbiology, yeast,
nutrition, functional food design and testing,
metabolomics and metagenomics.
He has over 90 peer reviewed publications in the area of
food and gut microbiology and an H-index of 37.
Prof. Kieran Tuohy
26
One ILSI approach
Europe’s proposal for the One ILSI
Communication tool: ILSI Exchange Platform on
‘Human Microbiome and Health’
• To facilitate inter-branch communication
• To exchange knowledge across ILSI branches
• To support the identification of topics of mutual interest and
emerging issues in the field;
• To trigger global cooperation and collaboration.
 Anticipated result: One ILSI projects on topic
related to human microbiota and its
crosstalk with host physiology
27
One ILSI approach
Europe’s proposal for the One ILSI
Short-term objective
To initiate a branch dialog, to share information
and to set up the exchange platform.
• ILSI Europe session on ‘Human Microbiome and Health’
@ the 2016 ILSI Annual Meeting
(25 January 2016, 2:00 – 5:30 pm, St. Petersburg, USA)
• Focus: Role of human microbiota for health and wellbeing
 Excellent opportunity to initiate a branch dialog and to
share information on regional activities
• 9 branches are contributing
28
One ILSI approach
Europe’s proposal for the One ILSI
9 ILSI branches are contributing
ILSI Europe contribution:
Impact of the gut microbiome on nutrients and non-nutrients
metabolism and energy availability
 Summary of the results of the ILSI Europe Functional Foods
and Prebiotics Task Forces’ joint Expert Group ‘Exploring the
role of the Major Gut Microbiota Cluster’ and THIS ILSI Europe
Workshop
29
Human Microbiota as Transversal
Topic for ILSI Europe Task Forces
• Expert group: Exploring the Role of the Major Gut
Microbiota Clusters on Nutritional and Functional
Benefits of Nutrients and Non-nutrients
• Expert group: Oral and systemic health resilience
Human Microbiota as Transversal
Topic for ILSI Europe Task Forces
• Expert group: Exploring the Role of the Major Gut
Microbiota Clusters on Nutritional and Functional
Functional
Benefits
of Nutrients and
Non-nutrients Obesity and
Prebiotics
Foods
Diabetes
• Expert group: Oral and systemic health resilience
Metabolic
Imprinting
Probiotics
Nutrition
Immunity and
Inflammation
Nutrition and
Mental
Performance
Emerging
Microbiological Issues
Functional Foods Task Force
Upcoming Publication
P. C. Calder, et al. Improving
Selection of Markers in Nutrition
Research: Evaluation of the
Criteria Proposed by the ILSI
Europe Marker Validation Initiative
(paper submitted).
Publication New!
B. Halliwell. Antioxidant and Antiinflammatory Components of
Foods. ILSI Europe Concise
Monograph Series 2015: 1-34.
Overview of the state-of-the-art
relating to free radicals,
antioxidants and inflammation.
Obesity and Diabetes Task Force
Publication New!
A. M. Minihane, et al. Low-grade
Inflammation, Diet Composition
and Health: Current Research
Evidence and its Translation.
British Journal of Nutrition 2015;
114(7):999-1012.
Based on a workshop, a coalition
of experts explains how nutrition
influences inflammatory
processes and help reduce
chronic diseases risk.
PODCAST New!
On ‘Low-grade Inflammation'
summarising a series of recent
ILSI Europe publications in this
field. With kind participation of
Prof. Philip Calder (University of
Southampton, UK).
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