nicotinamide riboside : the new vitamin b3

NICOTINAMIDE RIBOSIDE : THE NEW VITAMIN B3
Professor Anthony Sauve
Weill Medical College of Cornell University,
Department of Pharmacology
1
Introduction
NAD+ is a central metabolite that is involved in
energy metabolism. Increasing interest in influencing
physiologic levels of this metabolite has resulted in a
search for new agents that could stimulate its
production in cells.
2
3
Vitamin B3 forms
NR is found in Beer and Milk
IMPROVES
STRESS RESISTANCE
IMPROVES
ENERGY
METABOLISM
LOWERS
CHOLESTEROL?
Known precursors to NAD+ include nicotinic acid
(Niacin) and nicotinamide, which are broadly available
in pharmacies (as Vitamin B3) and in food sources.
NR stimulates NAD+ levels in cells and
tissues
NR is converted to NAD in cells and tissues
Nicotinamide
Nicotinic Acid
We have discovered that nicotinamide riboside (NR),
can provide very large enhancements in cellular NAD
levels, and is a new form of Vitamin B3, that is more
potent than nicotinamide or niacin for this purpose.
4
NAD
NEURO
PROTECTIVE
Nicotinamide Riboside
A PATENTED SYNTHESIS OF NR HAS BEEN
DEVELOPED BY THE SAUVE LABORATORY
NR INCREASES NAD IN ANIMALS
DOES NOT CAUSE FLUSHING
PROTECTS
GENOME
SIRTUIN
ACTIVATION
NR provides a new Vitamin B3 that can
stimulate improved health
REDUCES WEIGHT GAIN AND CHOLESTEROL
85%
ELLE (French edition) JUNE 2012
AND INCREASES MITOCHONDRIA AND ENDURANCE
“La biere et le lait deux alliés
minceur”:
“Beer and milk, two allies to achieve
thinness:”
“Ces deux boissons aideraient à
mincir. Ou plutôt, une des molécules
qu’elles contiennent : la nicotinamide
riboside (NR)…..”
Yang T, Chan, YC, Sauve AA (2007) Syntheses of nicotinamide riboside and
derivatives: Potent agents for increasing NAD concentrations in mammalian cells
J Med. Chem . 50, 6458
“Nicotinoyl riboside compositions and methods of use” Sauve AA, Yang T, U. S.
Patent 8,106,184: 2012
“These two drinks would help one to slim down.
Or rather, one of the molecules they contain:
the nicotinamide riboside (NR) ….”
The NAD(+) Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects
against High-Fat Diet-Induced Obesity. Cell Metab 2012, 15, 838-47.