Director: Petros Koutrakis Ph.D. Deputy Director: John Godleski M.D.

Director: Petros Koutrakis Ph.D.
Deputy Director: John Godleski M.D.
Project PIs: Joel Schwartz Ph.D.
Murray Mittleman M.D., Diane Gold M.D.
Francesca Dominici Ph.D., and Brent Coull Ph.D.
Co-PIs: Michelle Bell Ph.D., Frank Speizer M.D.
David Bellinger Ph.D., Matthew Gillman M.D.
Laura Kubzansky Ph.D., Emily Oken M.D.
Harvard University
Veterans Administration Boston Hospital
and Yale University
Investigate the acute and chronic effects across the life
course of short- and long-term exposures to individual
pollutants, pollution sources and multi-pollutant mixtures:
Outcomes:
 Cognitive/neuropsychological function
 Cardiovascular/endothelial function
 Inflammation
 Birth weight/growth
 CVD-related hospitalization/mortality
2
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Project 1: Animal Toxicological Study (Godleski)
Projects 2, 3 and 4 (New England Cohorts):
◦ Normative Aging Study (Schwartz)
◦ Framingham Cohort (Mittleman)
◦ VIVA Birth Cohort (Gold)
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Project 5: The National Study (Dominici)
Exposure and Engineering Cores (Koutrakis)
Biostatistics Core (Coull)
Administrative Core (Koutrakis)
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Fourth year
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A very productive year:
◦ Many intra- and inter-Center collaborations
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99 publications since the start of this current Center
◦ A publication list was posted in the meeting website
CLARC PUBLICATIONS
2011
2012
2013
2014
TOTAL
13
42
33
11
99
PM CENTER PUBLICATIONS
2007
2008
2009
2010
2011
2012
TOTAL
10
19
21
24
19
20
113
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Meeting website (by Alice Smythe)
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Agenda
Science Advisory Committee
Publications
Posters
Presentations
Contact
2013 SAC Meeting Website
Harvard CLARC Website
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Today – Pechet Room
8:45 – 9:00 Welcome and Introduction (Koutrakis, Thomas)
9:00 – 9:45 Exposure, Engineering and Biostatistics Cores, Toxicology
9:45 – 11:15 Poster Session 1/Coffee – Rooms 214, 216 & 217 - All
11:15 – 12:15 Discussion Thomas and SAC Members
12:15 – 1:15 Lunch break
1:15 – 2:15 Updates: 3 Cohorts, National Study, Epi Studies
(Schwartz, Gold, Mittleman, Dominici)
2:15 – 3:45 Poster Session 2/Coffee – Rooms 214, 216 & 217 - All
3:45– 5:15 Discussion Thomas and SAC Members
6:00 Dinner, Elements Café – Joseph B. Martin Center
Friday, June 6th – 401 Park Dr. (Landmark Ctr West) Rm 410-a
8:30 – 9:00 Breakfast SAC Members
9:00 – 11:00 Committee Meets Alone SAC Members
11:00 – 11:30 Break
11:30 – 1:30 Discussion and Lunch SAC, PIs and EPA
1:30 Adjourn
Petros Koutrakis, PI
Harvard CLARC
SAC meeting, June 5-6, 2014
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Project team; Petros Koutrakis, Mike Wolfson, Joy
Lawrence, Steve Ferguson, Choong Min Kang, Vasileios
Papapostolou, Alexandra Chudnovsky, Elena Austin and
Hyung Joo Lee, Rima Habre, Iny Jhun, Jessie Tang,
Youn-Suk Son, Weeberb Réquia
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Integration across Projects and Cores
◦ Working closely with all PIs of Projects 1-5
◦ Working closely with the Biostatistics Core for the development
of spatially- and temporally-resolved exposures
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Engineering Core: Monitoring and Chamber Study
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Boston Harvard Supersite
New England speciation sites
National PM and Speciation Sites
Generation and characterization of animal exposures
AOD satellite data
Exposure Core: Similar Exposure Metrics for all
human studies
• Pollutant Concentrations (Monitoring Sites)
• Sources Contributions (Receptor Models)
• Pollutant Mixtures (Cluster Analysis)
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Review past year activities
Introduce Posters for the Engineering and Exposure
Cores
Present next year plans
Iraq: study area and selected major cities
Summer (JJA)
Spring (MAM)
Legend
Thiessen_spring
mean_aod
0.01 - 0.09
0.10 - 0.15
0.16 - 0.22
0.23 - 0.33
0.34 - 0.52
0.53 - 1.47
Fall (SON)
Winter (DJF)
Maps of AOD seasonal averages for 1997-2010 retrieved from SeaWIFS present the overall distributions of dust and
anthropogenic pollution aerosols over source regions. Evident are distinct intra- and inter-seasonal variability patterns.
Chudnovsky, Alexandra, Kostinski, Alex Garshick, Eric, Proctor, Susan P and Koutrakis, Petros. Use of Seaviewing Wide Field-of-view Sensor (SeaWiFS) to Characterize Dust Pollution Levels in Iraq. Under Review
Quebec Wildfires in 2002 & 2010
Wildfires
Wildfires
May 31, 2010
July 7, 2002
 In early July 2002, ~85 wildfires in province of Quebec destroyed ~1,000
km2 of forest land, at locations ~1000 km northwest Boston. In late May
2010, ~50 wildfires burned ~880 km2 of forest land, at locations ~700 km
northwest Boston.
 Backward air trajectories indicate that the smoke plumes originated from
wildfire areas in Quebec, Canada passed through the US upper states in
both 2002 and 2010
Impact on O3 in Northeastern US
Smoke days
Adjacent days
 O3 measurement: 153 U.S. EPA sites and 112 Canada NAPS sites
 Increase of at least 10 ppbv O3 8hr max in Northeastern US.
 Significant enhancements observed in rural (North Toronto) and urban
areas (NYC, Philadelphia)
Impact on PM species in Boston
Wildfire
2010 Episode
 PM2.5 and PM10 increased to 151
and 165 μg/m3, respectively
 Most species. except for SO42-,
were enhanced: PM2.5, PM10,
PM2.5/PM10 , OC, EC, BC,
Some elements (K, Cl, Zn Br,
and Mn).
 Of species, OC enhancement was
the most dominant; in particular,
OC3, pyrolysis carbon, and EC1,
which are likely related with
pyrolysis of structural
components of wood.
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Papapostolou V, Lawrence JE, Ferguson ST, Wolfson JM, Diaz EA, Godleski
JJ, et al. Development and Characterization of an Exposure Generation
System to Investigate the Health Effects of Particles from Fresh and Aged
Traffic Emissions. Air Quality, Atmosphere and Health 2013,6:419 - 429.
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Lee HJ, Koutrakis P. Daily Ambient NO2 Concentration Predictions Using
Satellite Ozone Monitoring Instrument NO2 Data and Land Use Regression.
Environmental Science & Technology 2014,48:2305-2311.
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Chudnovsky A, Lyapustin AW, Y., Tang C, Schwartz J, Koutrakis P. High
Resolution Aerosol Data from MODIS Satellite for Urban Air Quality
Studies. Central European Journal of Geosciences Accepted.
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Austin, E., Zanobetti, A., Coull, B., Schwartz, J., Gold DR. , Koutrakis, P.
(2014). Ozone trends and their relationship to characteristic weather patterns.
Journal of Exposure Science and Environmental Epidemiology (Accepted).
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Chudnovsky, A., Kostinski, A., Lyapustin, A., and Koutrakis, P. (2013) Spatial
Scales of Pollution from Variable Resolution Satellite Imaging, Environmental
Pollution 172, 131 - 138.
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Chudnovsky, A., Tang, Lyapustin, A., Wang, Y., Schwartz, J. and Koutrakis, P.
Critical assessment of high resolution aerosol optical depth (AOD) retrievals
for fine particulate matter (PM) Predictions. Atmospheric Chemistry and
Physics 2013,doi:10.5194/acp-13-10907-2013.
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Austin, E., Coull, B.A., Zanobetti, A., Koutrakis, P. (2013) A framework to
spatially cluster air pollution monitoring sites in US based on the PM2.5
composition, Environment International, Accepted.
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McDevitt JJ, Koutrakis P, Ferguson ST, Wolfson JM, Fabian MP, Martins M,
et al. Development and Performance Evaluation of an Exhaled-Breath
Bioaerosol Collector for Influenza Virus. Aerosol Science and Technology
2013,47:444 - 451.
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Krasnov H, Katra I, Koutrakis P, Friger MD. Contribution of Dust
Storms to PM10 Levels in an Urban Arid Environment. Journal of the
Air and Waste Management Association 2014,64:89 - 94.
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Jhun I, Oyola P, Moreno F, Castillo MA, Koutrakis P. PM2.5 Mass and
Species Trends in Santiago, Chile, 1998 to 2010: The Impact of FuelRelated Interventions and Fuel Sales. Journal of the Air and Waste
Management Association 2013,63:161 - 169.
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Diapouli E, Chaloulakou A, Koutrakis P. Estimating the
Concentration of Indoor Particles of Outdoor Origin: A Review.
Journal of the Air and Waste Management Association 2013,63:1113–
1129.
 Jhun I, Coull BA, Schwartz J, Hubbell B, Koutrakis P; Impact
of Climate Change on Air Quality and Health in the United
States in 1994 - 2012
 Kang C-M, Gold D, Koutrakis P; Downwind O3 and PM2.5
Speciation During the Wildfires in 2002 & 2010
 Lee W-C, Wolfson JM, Koutrakis P; Air Purifier Performance
and the Spatial Variation in a Single Residential Room
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Masri SF, Kang C-M, Koutrakis P; Composition and Sources of
Fine and Coarse particles Collected durign 2002-2010 in Boston,
MA
Son Y-S, Kang C-M, Wolfson JM, Ferguson S, Bailey A, Regos
D, Phipatanakuk W, Koutrakis P; Improving the Indoor Air
Quality of Classrooms Using Air Cleaners
Tang J C-H, Koutrakis P; A Comparison of Three
Spatiotemporal Models Estimating Daily PM2.5 Concentration
in the New England Region
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Continue monitoring at the Boston superesite
◦ Up to date (a series 1999-2013) 15 years!
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Publications
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Coarse PM
Comparison of statistical methods for AOD data analysis
Effect of meteo on pollution and health
Visibility for retrospective exposure assessment of veterans
Canadian Fires
Numerous epi and tox studies
Implement NO2 OMI satellite based model