Book expertise Lipomassage

Lipomassage
TM
by endermologie
®
Expertise
Scientific Research Department LPG Systems, Sophia-Antipolis, France
© Copyright LPG Systems 2008
The cellu m6®: A 20-year experience
Originally, the Cellu M6 was used in the treatment of severe burns. While treating burnt
patients, unexpected results were observed: a visible improvement of cellulite appearance,
and a significant reduction of the fat fold.
Since 1986, 18 millions people treated worldwide and not one medical
device reporting (mdr) ever made.
Today: The Lipomassage
TM
The only scientifically proven tehnique, targeting the fat that is resistant
to diet and exercise.
[3]
Scientific Research Department
The MECHANOTRANSDUCTION
The Cellu M6 treatment heads mechanical stimulation on skin surface sends an in-depth
message to the cells that triggers various biological reactions.
[4]
Lipomassage actions
TM
A total of 16 published articles by French, Italian and American medical teams, and more
than 100 oral communications in medical congresses (Visit www.cosire-lpg.com) that
demonstrate the Lipomasssage 4 actions.
4 Actions:
ROLL’IN
Release
ROLL’UP
Resculpt
➜ gluteal fold, asymmetries
ROLL’UP
major
ROLL’OUT
Smooth
➜ c ellulite
Firm
[5]
Scientific Research Department
1. Release Action
ROLL’IN
SCIENTIFIC STUDIES
Action on adipocytes: a breakthrough discovery
1. MONTEUX C. & LAFONTAN M. Use of the microdialysis technique to assess lipolytic
responsiveness of femoral adipose tissue after 12 sessions of mechanical massage technique.
Submitted.
Study specificities:
> Collaboration with Pr Lafontan, the international adipose tissue (fat tissue) specialist
> Use of a very precise evaluation method: the microdialysis
> Study on femoral adipose tissue, known to have a very slow fat release
> Use of LIPOMASSAGE (3 x/week for 1 month, with a total of 12 sessions)
Study chart
SELECTION
and INCLUSION
(9 subjects)
EVALUATIONS
LIPOMASSAGE Treatment
V1
s1 s2 s3 s4 s5 s6 s7 s8 s9 s10 s11 s12
V0
2 weeks
3 sessions/week.
for 4 weeks (12 sessions)
3 days
before
[6]
EVALUATIONS
- Microdialysis*
- Skin fold
- Perimetry
- Cellulite Grade
1 month
- Microdialysis*
- Skin fold
- Perimetry
- Cellulite Grade
V2
12 to 24 h
after
* Microdialysis consists in introducing double circulation probes in
adipose tissue in order to study lipolysis at a given time, by released
glycerol dosages.
ROLL’IN
Release
Resculpt
Smooth
Firm
SCIENTIFIC STUDIES (cont’d)
Action on adipocytes: a breakthrough discovery (cont’d)
Subjects characteristics
Average ± SD
Min-Max
Age, years
41.2 ± 3.6
36-45
Height, cm
164.89 ± 8.34
155-180
Weight, kg
74.37 ± 13.44
60-97
Body Mass Index,
kg/m2
27.16 ± 0.95
22.58-29.94
Clinical results
After 12 sessions with Lipomassage, perimetry, skin fold measurement, and cellulite
grade significant reduction.
before
LIPOMASSAGE
AFTer
LIPOMASSAGE
P
Waist circumference (cm)
97.8 ± 3.6
96.1 ± 3.6
<0.01
Hip circumference (cm)
108.7 ± 4.0
108.6 ± 4.0
NS
Right thigh circumference
(cm)
64.7 ± 3.8
61.6 ± 3.0 (-3.3 cm)
<0.01
Left thigh circumference
(cm)
64.7 ± 3.8
61.4 ± 3.0 (-3.1 cm)
<0.01
Right skin fold measurement
(mm)
28.4 ± 1.7
24.8 ± 1.4
<0.001
Left skin fold measurement
(mm)
28.4 ± 1.7
24.6 ± 1.4
<0.001
Cellulite grade
2.4 ± 0.2
1.7 ± 0.2
<0.01
Scientific Research Department
[7]
1. Release Action
SCIENTIFIC STUDIES (cont’d)
Action on adipocytes: a breakthrough discovery (cont’d)
METABOLIC RESULTS
Significant improvement of fat release after 12 Lipomassage sessions (improved femoral
adipose tissue reactivity by lipolytic Beta receptors resensitization).
Glycerol evolution (%)
100
Before
After
80
% 60
40
20
0
0
0.1
1
10
Isoproterenol (μm)
Results Comparaison
The Lafontan Study results are the same that the ones observed in a study carried out on
overweight subjects’ abdominal tissue after 4 months of intensive training.**
Change of glycerol dialysate (μmol/l)
Intense training study**
[8]
140
* *
120
100
80
60
40
*
20
0
-20
-15 0
isoproteremol
15 30 45 60 75 90 105 120 (min.)
Lipomassage study*
100
90
80
70
60
50
40
30
20
10
0
0
Before After
0.1
1
10
Before After
* MONTEUX C & LAFONTAN M. Use of the microdialysis technique to assess lipolytic responsiveness of femoral adipose
tissue after 12 sessions of mechanical massage technique (submitted)
** Moro et al. Medecine & Science in Sports & Exercice 2005, 37: 1126-1132
ROLL’IN
Resculpt
Release
Smooth
Firm
Clinical results
Action on adipocytes
aGE
33 years old
lipomassage
Roll’in: 60%
Roll’up: 30%
Roll’out: 10%
Session 0
Session 0
Session 14
Session 10
Session 0
aGE
42 years old
aGE
38 years old
lipomassage
Roll’in: 20%
Roll’up: 50%
Roll’out: 30%
lipomassage
Roll’in: 50%
Roll’up: 40%
Roll’out: 10%
Session 14
Scientific Research Department
[9]
2. Resculpt Action
ROLL’UP
SCIENTIFIC STUDIES
Contours improvement, loss of centimeters: 7 referenced studies
1. MONTEUX C. & LAFONTAN M. Use of the microdialysis technique to assess lipolytic
responsiveness of femoral adipose tissue after 12 sessions of mechanical massage technique.
Submitted.
2. ORTONNE J.P. et al.Treatment of cellulite: Effectiveness and sustained effect at 6 months
with Endermologie® demonstrated by several quantitative evaluation methods. Nouv.
Dermatol. 2004; 23: 261-269
3. KINNEY B. Liposuction surgery and the use of Endermologie®. Journal of Cutaneous
Laser Therapy 2001; 3: 24
4. DABB R.W. A combined Program of Small-volume Liposuction, Endermologie® and
Nutrition: A Logical Alternative. Aesthetic Surg J 1999, 19 (5); 388-97
5. CHANG P et al. Noninvasive Mechanical Boby Contouring: Endermologie® A One-Year
Clinical Outcome Study Update. Aesth. Plast. Surg. 1998, 22; 145-53
6. ERSEK R.A., et al. Noninvasive Mechanical Boby Contouring: A Preliminary Clinical
Outcome Study. Aesth. Plast. Surg. 1997, 21; 61-67
7. DAVER J. Une nouvelle méthode instrumentale du traitement de la cellulite. Médecine au
féminin 1991, n°39, p.25-34
[10]
Release
ROLL’UP
Resculpt
Smooth
Firm
SCIENTIFIC STUDIES (Cont’d)
Contours improvement, loss of centimeters: 7 referenced studies (cont’d)
Circumference measurements
Significant body perimeters reduction*:
AFTER 7 sessions
AFTER 14 sessions
ERSEK 1997
1.38 cm (n= 22)
2.84 cm (n= 6)
CHANG 1998
1.19 cm (n= 46)
1.83 cm (n= 39)
* Circumferences measured on 5 anatomical sites, and then averaged (waist, hip, thigh, knee, ankle)
Thigh circumference measurements
Significant thigh perimeter reduction:
DAVER 1991
3.5 cm (n= 12)
20 sessions
ORTONNE 2004
1 cm
(Up to 4.3 cm) (n= 30)
16 sessions
LAFONTAN 2007
(Lipomassage)
3.3 cm
(Up to 8 cm) (n= 9)
12 sessions
LIPOMASSAGE: More results with less sessions
[11]
Scientific Research Department
2. Resculpt Action
Clinical results
Body contours improvement, centimeters loss
Session 0
[12]
Session 14
Session 0
aGE
38 years old
aGE
30 years old
lipomassage
Roll’in: 50%
Roll’up: 40%
Roll’out: 10%
lipomassage
Roll’in: 33%
Roll’up: 33%
Roll’out: 33%
Session 14
Release
ROLL’UP
Resculpt
Smooth
Firm
Clinical results (CONT’D)
Body contours improvement, centimeters loss (cont’d)
Session 0
Session 14
aGE
30 years old
lipomassage
Roll’in: 30%
Roll’up: 50%
Roll’out: 20%
[13]
Scientific Research Department
3. smooth Action
ROLL’UP Major
SCIENTIFIC STUDIES
Anti-cellulite effect: 7 referenced studies
1. ORTONNE J.P., et al. M. Treatment of cellulite: Effectiveness and sustained effect at 6
months with Endermologie® demonstrated by several quantitative evaluation methods. Nouv.
Dermatol. 2004; 23: 261-269
2. KINNEY B. Endermologie® (the LPG® Technique) and cellulite: my clinical practice. Journal
of Cutaneous Laser Therapy 2001; 3: 15-16.
3. La TRENTA G.& MICK S. Endermologie® after External Ultrasound-assisted lipoplasty
(EUAL) versus EUAL alone. Aesthetic Surg J 2001, 21 (2); 128-36
4. La TRENTA G. Endermologie® versus Liposuction with External Ultrasound Assist. Aesthetic
Surg J 1999, 19 (6); 452-58.
5. FODOR P.B. Endermologie® and Endermologie®-assisted Lipoplasty Update. Aesthetic
Surg J 1998, 18 (4); 302-04
6. FODOR P.B. Endermologie® (LPG): Does It Work? Aesth. Plast. Surg. 1997, 21; 68
7. CUMIN M.C. Use of LPG System during lipoaspirations (185 cases) J. Méd. Esth. et Chir.
Derm., Vol XXIII, 91, Septembre 1996, p.185-188
[14]
ROLL’UP Majeur
Release
Resculpt
Smooth
Firm
SCIENTIFIC STUDIES (CONT’D)
Anti-cellulite effect: 7 referenced studies (cont’d)
Cutaneous imprints
Reduction of dimpled aspect -20% (ORTONNE 2004):
Session 0
session 16
Sonography 20 MHz
Dermo-hypodermic junction smoothing, sign of cellulite reduction (ORTONNE 2004):
session 0
session 16
[15]
Scientific Research Department
3. smooth Action
SCIENTIFIC STUDIES (CONT’D)
Anti-cellulite effect: 7 referenced studies (cont’d)
Liposuction surgery results optimization
CUMIN, 1996
Smoothing of orange peel appearance; n= 185 subjects
FODOR, 1997
Smoothing post-operative skin surface; n= 20 subjects
FODOR, 1998
Smoothing post-operative skin surface; n= 143 subjects
La TRENTA, 1999
Cellulite improvement by 50%; n= 36 subjects
La TRENTA, 2001
Cellulite improvement by 50%; n= 25 subjects
KINNEY, 2001
Smoothing post-operative skin surface; n= 100 subjects
Total: n= 509 subjects
Clinical results
aGE
48 years old
lipomassage
Roll’in: 40%
Roll’up: 40%
Roll’out: 20%
[16]
Session 0
Session 14
ROLL’UP Majeur
Release
Resculpt
Smooth
Firm
Clinical results (CONT’D)
Anti-cellulite effect (cont’d)
aGE
28 years old
lipomassage
Roll’in: 40%
Roll’up: 50%
Roll’out: 10%
Session 0
Session0
Session 12
Session 9
aGE
46 years old
lipomassage
Roll’in: 10%
Roll’up: 50%
Roll’out: 40%
[17]
Scientific Research Department
4. firm action
ROLL’OUT
SCIENTIFIC STUDIES
Restructuring and redensifing action: 4 referenced studies
1. INNOCENZI D. et al. Evidenza delle modificazioni cutanee indotte dalla tecnica LPG
mediante analise d’immagini. DermoCosmetologia Anno II, n°1 – Gennaio/Marzo 2003;
p. 9-15
2. INNOCENZI D. et al. Alterazioni morfologiche della cute indotte con la tecnica LPG®.
DERMOtime Settembre/Ottobre 2002, anno XIV, n°7/8; p. 25-27
3. ADCOCK D. et al. Analysis of the effects of deep mechanical massage in the porcine
model. Plast. Reconstr. Surg. 2001 Jul., 108 (1); 233-40
4. ADCOCK D et al., Analysis of the cutaneous and systemic effects of the Endermologie® in
the porcine model. Aesthetic Surgery. J. 1998,18 (6); 414-22
[18]
Release
Resculpt
Smooth
ROLL’OUT
Firm
SCIENTIFIC STUDIES (CONT’D)
Restructuring and redensifing action: 4 referenced studies (cont’d)
Histology Animal model
Increase in collagen content +130% (ADCOCK 1998, 2001):
BEFORE
aFTER 20 sessions
Histology Human Tissue / signs of skin ageing
Epidermis thickening + 31% and dermo-epidermal junction remodeling
(INNOCENZI 2002, 2003):
BEFORE
AFTER 14 sessions
[19]
Scientific Research Department
4. firm action
SCIENTIFIC STUDIES (CONT’D)
Restructuring and redensifing action: 4 referenced studies (cont’d)
Histology / image analysis
Increase of fibroblasts nuclei surface 54.6% (INNOCENZI 2003):
surface of fibroblasts nuclei (μm2)
3 000
+ 54.6%
>
2 500
2 000
1 500
1 000
500
0
NOT TREATED
NOT TREATED
[20]
TREATED (14 sessions)
TREATED (14 sessions)
Release
Resculpt
Smooth
ROLL’OUT
Firm
Clinical results
Restructuring and redensifing action
Results
aGE
55 years old
lipomassage
Roll’in: 50%
Roll’up: 25%
Roll’out: 25%
before
Intermediate
after
[21]
Scientific Research Department