CV Sketch - Neuroimmunology Program

Elena H Martínez-­‐Lapiscina MD PhD November 30th 2015 BIOGRAPHICAL SKETCH
Complete for each professional associated with the project
Name: [First, Middle Initial(s), Last, Degree(s)]
Position/Title:
Elena Hernández Martínez-Lapiscina, M.D. PhD
Research Associate (IDIBAPS)
Neurologist (Hospital Clinic Barcelona)
Education
Institution and Location
Degree
University of Navarra, Pamplona Spain
Complejo Hospitalario de Navarra, Spain
University of Navarra, Pamplona Spain
Institute of Biomedical Sciences August Pi i
Sunyer (IDIBAPS)
MD
Residence
PhD
Postdoctoral
Fellowship
Year
Conferred
June 2006
May 2012
May 2013
Jan 2014
Field of Study
Medicine
Neurologist
Neurosciences
Neuroimmunology
& Neuroimaging
RESEARCH EXPERIENCE
Jan 2014-Actual Institute of Biomedical Sciences August Pi i Sunyer Barcelona,
Spain as Postdoctoral Research associate with the National Program of
Research Fellowship Río Hortega
July 2014-October 2014 University of California San Francisco (UCSF) as
Postdoctoral Research associate
May 2012- Jan 2014 Institute of Biomedical Sciences August Pi i Sunyer,
Barcelona, Spain Predoctoral Research assistant
May 2008-May 2013 Epidemiology and Public Health Department, University of
Navarra, Spain Predoctoral Research assistant
HONORS AND AWARDS
2014 Forth position in the National opposition for Fellowship Río Hortega,
Barcelona, Spain
2012 Full Fellowship for the Symposium Methodology for Clinical Research,
Harvard University – Real Colegio Complutense, Boston, US.
2007 Award for the first position in MIR National Examination by "Cursos
Intensivos MIR Asturias, S. L"
2007 First position in MIR National Examination held annually for the election of
MD specialization in Spain, 2007 (1/>10.000 applicants): Neurology
2006 Accreditation as one of the top 5 academic records of promotion, 2006
(3.81/4) in University of Navarra.
2006 Special mention at the National Spanish Award Degree (2005-2006)
awarded by the Ministry of Education and Science, Spain Order ECI/2922/2006
(B.O.E. 25 September 2007)
1 Elena H Martínez-­‐Lapiscina MD PhD November 30th 2015 PROFESSIONAL ACTIVITIES
Scientific Boards
• Member of Scientific Advisory Board of Translational Committee of
Spanish Neurological Society.
• Member of Scientific Advisory Board of Junior Neurologist Committee of
Spanish Neurological Society.
• Member of the Working Committee of International Multiple Sclerosis
Visual System Consortium [IMSVISUAL]. The overarching goal of
IMSVISUAL is to establish the visual system as a model within which to
monitor neurodegeneration in multiple sclerosis (MS) and related
disorders, both for tracking patients, as well as outcome measures in
clinical trials. More details on http://www.imsvisual.org/
Ad hoc reviewer for:
Annals of Neurology, Multiple Sclerosis Journal, PloSOne, Neurodegenerative
Disease Management, British Journal Nutrition, Mechanisms of Ageing and
Development, Nutritional Neurosciences.
TEACHING
Formal: School of Medicine
2008-2012
Mentor of medical students for the clinical track of the Medical
school, University of Navarra
2014-2015
Mentor MD projects of the Medical School, University of
Barcelona. MD Candidate: Miquel Marqués. Title: Semantic Networks in
Multiple Sclerosis. Defense: 16 January 2015
2012-2014
Co-Director of PhD Project “Dynamic Axonal damage in
Multiple Sclerosis Evaluation by using Neuroimaging Modalities in the afferent
visual pathway” Iñigo Gabilondo. Date 10 June 2014. Award Cum Laude
2014-2015
Co-Director of PhD Project “Visual abnormalities as prognostic
biomarkers in Multiple Sclerosis” Santiago Ortiz. Date 27 February 2015. Award
Cum Laude
Informal: MIR Examination Academy
2010-Actual Pharmacology professor at MIR Asturias Academy, Asturias, Spain
Students and fellows supervised or mentored
Dates
2015
2014-2015
Name
Boglárka Varga
Santiago Ortiz-Perez
Program or School
Fellowship
Fellowship
2014-2015
Erika J. Lampert
2014
Miquel Marqués Camì
Undergraduate
Fullbright
Medicine Degree
2014
Alba de Los Santos
Capdevila
Iñigo Gabilondo
2012-2014
Biomedical Engineer
Fellowship
Role
Research mentor
Research mentor
Co-director of PhD
Research mentor
Supervised final
degree work
Supervised final
degree work
Research support
Co-director of PhD
2 Elena H Martínez-­‐Lapiscina MD PhD November 30th 2015 CLINICAL ACTIVITIES
Department of Neurology at Hospital Clinic of Barcelona: Neurologist, Multiple
Sclerosis Center. Hospital Clinic of Barcelona (2 day/week): Day Care Hospital
and MS and Immune- mediated disorders Outpatient Clinic.
RESEARCH PROGRAM
Keyword/Areas of Interest: Multiple Sclerosis, Neuroimmunology, Translational
Research (Biomarker and therapeutic target R&D), Neuroimage and Visual
Pathway, Telemedicine and Public Health (Mediterranean Diet).
Axonal damage in MS/AON: we aim to further understand the dynamics of
axonal damage in Multiple Sclerosis and Optic Neuritis and its main contributors
(oxidative stress, energetic failure). For this aim, we combined Imaging
Modalities in animal models and patients with MS (MRI, OCT and Raman
Spectroscopy). We have identified the role of Tran synaptic degeneration as
contributor factor to extend neuroaxonal damage in Multiple Sclerosis. We aim
also to evaluate the short and long-term dynamics of retinal atrophy after an
acute episode of optic neuritis.
Biomarkers of Prognosis in MS/AON: we aim to develop and validate
biomarkers of Multiple Sclerosis prognosis and to define pathogenic-related MS
phenotypes to achieve the goal of tailored therapy. We have already evaluated
the role of retinal periphlebitis in MS and color vision as makers of disease
severity in Relapsing Remitting MS and will evaluate these and other visual
outcomes (low contrast vision) in long-term cohorts and also for Progressive MS
patients. We have also designed an optical device based on Raman
Spectroscopy to evaluate molecular information of the retina in Multiple
Sclerosis.
Molecular
changes
associated
to
inflammation
and
neurodegeneration in MS are previous to structural and functional changes and
can reveal differences in the pathogenesis between individuals. Molecular
evaluation in retina by using Raman Spectroscopy will provide biomarkers of
prognosis and response to therapy for patients and insights into MS
pathogenesis, which will help in the development of new therapies for MS.
Telemedicine in MS: we aim to develop a platform to monitor chronic
Progressive MS patients by using telemedicine software and device. These
disabled patients have several limitations to come to neurologist outpatient and
for this reason they suffer medical complications (urological infections,
neuropathic pain, skin ulcers) longer until general physicians finally assist them.
We want to detect these medical complications to improve quality of life and
improve healthcare in this chronic disease.
Public Health: Counteracting disability due to Primary Neurodegenerative
Disorders such as Alzheimer Disease and Vascular Disease are challenge for
XXI. We have found a clear benefit of Mediterranean Diet to prevent cognitive
decline in Spanish population of the NAVARRA-Node of PREDIMED Study. We
are interesting in expand this evidence in SUN Cohort of University of Navarra
and in the new PREDIMED-Plus.
A) PEER-REVIEWED PUBLICATIONS
3 Elena H Martínez-­‐Lapiscina MD PhD November 30th 2015 ResearcherID: L-1161-2014 Metrics: Total articles in publication list: 37. Articles
with citation data: 25 Sum of the Times Cited: 947. Average Citations per
Article: 37.88. H-Index: 8 [11/30/2015].
1. Eloy Martinez-Heras; Federico Varriano; Vesna Prckovska; Carlos Laredo;
Magi Andorra; Elena H. Martinez-Lapiscina; Anna Calvo; Pablo Villoslada;
Albert Saiz; Alberto Prats-Galino; Sara Llufriu. Improved framework for
tractography reconstruction of the optic radiation. PLoS One. 2015 Sep
16;10(9):e0137064. doi: 10.1371/journal.pone.0137064. IF 3,534 [Q1]
2. Sepulveda M; Ros C; Martinez-Lapiscina EH; Solà-Valls N; Hervàs M;
Llufriu S; Blanco Y; La Puma D; Villoslada P; Casals E; Graus F; CastedoBranco C; Saiz A. Pituitary-ovary axis and ovarian reserve in fertile women
with multiple sclerosis: a pilot study. Mult Scler. 2015 Sep 11. pii:
1352458515602339. IF 4,863 [Q1]
3. Elena Abad; Jorge Sepulcre; Elena H Martinez-Lapiscina; Irati Zubizarreta;
Jordi Garcia-Ojalvo; Pablo Villoslada. The analysis of semantic networks in
multiple sclerosis identify preferential damage of long-range connectivity. Mult Scler Relat Disord. 2015;4(5):387-94. doi IF:0.88
4. Lampert EJ, Andorra M, Torres-Torres R, Ortiz-Pérez S, Llufriu S,
Sepúlveda M, Sola N, Saiz A, Sánchez-Dalmau B, Villoslada P, MartínezLapiscina EH. Color vision impairment in multiple sclerosis points to retinal
ganglion cell damage. J Neurol. 2015;262(11):2491-7 FI: 3,841 [Q1].
5. Valls-Pedret, C; Sala-Vila, A; Serra-Mir, M; Corella, D; de la Torre, R;
Martínez-González, MA; Martínez-Lapiscina, EH; Fitó, M; Pérez-Heras, A;
Salas-Salvadó, J; Estruch, E; Ros, E. MEDITERRANEAN DIET and AGERELATED COGNITIVE DECLINE: A Randomized Clinical Trial. JAMA Intern
Med. 2015;175(7):1094-103IF: 13,25 [D1]
6. Sola-Valls N, Blanco Y, Sepúlveda M, Llufriu S, Martínez-Lapiscina EH, La
Puma D, Graus F, Villoslada P, Saiz A. Walking function in clinical
monitoring of multiple sclerosis by telemedicine. J Neurol.
2015;262(7):1706-13.FI: 3,841 [Q1].
7. Malhotra A, Gündel M, Rajput AM, Mevissen HT, Saiz A, Pastor X, LozanoRubi R, Martinez-Lapiscina EH, Zubizarreta I, Mueller B, Kotelnikova E,
Toldo L, Hofmann-Apitius M, Villoslada P. Knowledge retrieval from PubMed
abstracts and electronic medical records with the Multiple Sclerosis
Ontology. PLoS One. 2015;10(2):e0116718. IF 3,534 [Q1]
8. Gabilondo I, Martínez-Lapiscina EH, Fraga-Pumar E, Ortiz-Perez S,
Torres- Torres R, Andorra M, Llufriu S, Zubizarreta I, Saiz A, SanchezDalmau B, Villoslada P. Dynamics of retinal injury after acute optic neuritis.
Ann Neurol. 2015 Mar;77(3):517-28 IF 11,910. [D1]
9. Martínez-González MÁ, Toledo E, Arós F, Fiol M, Corella D, Salas-Salvadó́
J, Ros E, Covas MI, Fernández-Crehuet J, Lapetra J, Muñoz MA, Fitó́ M,
Serra-Majem L, Pintó X, Lamuela-Raventós RM, Sorlí́ JV, Babio N, BuilCosiales P, Ruiz-Gutierrez V, Estruch R, Alonso A AND PREDIMED Study
Investigators including Martínez-Lapiscina EH. Extravirgin olive oil
consumption reduces risk of atrial fibrillation: the PREDIMED (Prevención
con Dieta Mediterránea) trial. Circulation. 2014;130:18-26. IF 14,98 [D1]
10. Martínez-Lapiscina EH, Fraga-Pumar E, Gabilondo I, Martínez-Heras E,
Torres-Torres R, Ortiz-Pérez S, Llufriu S, Tercero A, Andorra M, Roca MF,
Lampert E, Zubizarreta I, Saiz A, Sanchez-Dalmau B, Villoslada P. The
4 Elena H Martínez-­‐Lapiscina MD PhD November 30th 2015 multiple sclerosis visual pathway cohort: understanding neurodegeneration
in MS. BMC Res Notes. 2014;7:910. IF 2,853
11. Martínez-Lapiscina EH, Sanchez-Dalmau B, Fraga-Pumar E, Ortiz-Perez
S, Tercero-Uribe AI, Torres-Torres R, Villoslada P. The visual pathway as a
model to understand brain damage in multiple sclerosis. Mult Scler.
2014;20:1678-85. IF 4,863 [Q1]
12. Martínez-Lapiscina EH, Fraga-Pumar E, Pastor X, Gómez M, Conesa A,
Lozano-Rubí R, Sánchez-Dalmau B, Alonso A, Villoslada P.Is the incidence
of optic neuritis rising? Evidence from an epidemiological study in Barcelona
(Spain), 2008-2012. J Neurol. 2014;261:759-67 FI: 3,841 [Q1].
13. Martínez-Lapiscina EH, Ortiz-Pérez S, Fraga-Pumar E, Martínez-Heras E,
Gabilondo I, Llufriu S, Bullich S, Figueras M, Saiz A, Sánchez-Dalmau B,
Villoslada P. Colour vision impairment is associated with disease severity in
multiple sclerosis. Mult Scler. 2014;20(9):1207-1216 IF 4,863 [Q1]
14. Gabilondo I, Martínez-Lapiscina EH, Martínez-Heras E, Fraga-Pumar E,
Llufriu S, Ortiz S, Bullich S, Sepulveda M, Falcon C, Berenguer J, Saiz A,
Sanchez-Dalmau B, Villoslada P. Trans-synaptic axonal degeneration in the
visual pathway in multiple sclerosis. Ann Neurol. 2014;75:98-107. IF 11,910.
[D1]
15. Martínez-Lapiscina EH, Galbete C, Corella D, Toledo E, Buil-Cosiales P,
Salas- Salvado J, Ros E, Martinez-Gonzalez MA. Genotype patterns at
CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the
PREDIMED- NAVARRA trial. Genes Nutr. 2014;9:393. FI: 3.419 [Q1].
16. Gea A, Beunza JJ, Estruch R, Sánchez-Villegas A, Salas-Salvadó́ J, BuilCosiales P, Gómez-Gracia E, Covas MI, Corella D, Fiol M, Arós F, Lapetra
J, Lamuela-Raventos RM, Warnberg J, Pintó X, Serra-Majem L, MartínezGonzález MA AND PREDIMED Study Investigators including MartínezLapiscina EH Alcohol intake, wine consumption and the development of
depression: the PREDIMED study. BMC Med. 2013; 30;11:192 FI: 7.276
[D1]
17. Marro M, Taubes A, Abernathy A, Balint S, Moreno B, Sanchez-Dalmau B,
Martínez- Lapiscina EH, Amat-Roldan I, Petrov D, Villoslada P. Dynamic
molecular monitoring of retina inflammation by in vivo Raman spectroscopy
coupled with multivariate analysis. J Biophotonics. 2014;7(9):724-34 FI:
3.856 [Q1].
18. Santiago Ortiz-Pérez*, Martínez-Lapiscina EH*, Iñigo Gabilondo, Elena
Fraga-Pumar, Eloy Martínez-Heras, Albert Saiz, Bernardo Sánchez-Dalmau,
and Pablo Villoslada. Retinal periphlebitis is associated with Multiple
Sclerosis severity. Neurology 2013;81:877-81. *Equally author contributions.
FI: 8.303 [D1].
19. Gabilondo I, Sepulveda M, Ortiz-Pérez S, Fraga-Pumar E, MartínezLapiscina EH, Llufriu S, Solá N, Saiz A, Sánchez-Dalmau B, Villoslada P.
Retrograde retinal damage after acute optic tract lesion in MS. J Neurol
Neurosurg Psychiatry. 2013;84:824-6. FI: 5.580 [D1].
20. Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, GómezGracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM,
Serra-Majem L, Pintó X, Basora J, Muñoz MA, Sorlí JV, Martínez JA,
Martínez-González MA AND PREDIMED Study Investigators including
Martínez-Lapiscina EH. Primary prevention of cardiovascular disease with
a Mediterranean diet. N Engl J Med. 2013;368:1279-90. A FI: 51.658 [Q1].
5 Elena H Martínez-­‐Lapiscina MD PhD November 30th 2015 21. Martínez-Lapiscina EH, Clavero P, Toledo E, Sanjulian B, Sanchez-Tainta
A, Corella D, Lamuela-Raventos RM, Martínez JA, Martínez-González MA.
Virgin olive oil supplementation and long-term cognition: the PREDIMEDNAVARRA randomized, trial. J Nutr Health Aging. 2013;17:544-52. IF 2,659
[Q2]
22. Martínez-Lapiscina EH, Clavero P, Toledo E, Estruch R, Salas-Salvado J,
Sanjulian B, Sanchez-Tainta A, Ros E, Valls-Pedret C, Martínez-González
MA. Mediterranean diet improves cognition: The PREDIMED-NAVARRA
randomized trial. J Neurol Neurosurg Psychiatry. 2013;84:1318-25. A FI:
5.580 [D1].
23. Martínez-Lapiscina EH, Ayuso T, Lacruz F, Gurtubay IG, Soriano G, Otano
M, Bujanda M, Bacaicoa MC. Cortico-juxtacortical involvement increases
risk of epileptic seizures in multiple sclerosis. Acta Neurol Scand.
2013;128:24-31 IF 2,437 [Q2]
24. Martínez-Lapiscina EH, Lacruz F, Bolado-Concejo F, Rodríguez-Pérez I,
Ayuso T, Garaigorta M, Urman J. Natalizumab-induced autoimmune
hepatitis in a patient with multiple sclerosis. Mult Scler. 2013;19:1234-5. F
4,863 [Q1]
25. Martínez-Lapiscina EH, Erro Aguirre ME, Ayuso Blanco T, Jericó Pascual I.
Myasthenia gravis: sleep quality, quality of life and disease severity. Muscle
Nerve. 2012;46:174-80 IF 2,311 [Q2]
26. Martínez-Lapiscina EH, Erro ME, Cabada T, Tuñón T. 5-fluorouracil
induced hyperammonemic encephalophaty: etiopathological correlation.
Can J Neurol Sci. 2012;39:553-4. IF1,599 [Q3]
27. Martínez-Lapiscina EH, Pulido L, Erro E. Motor fluctuations in Parkinson
Diseases, a therapeutic approach. Rev Neurol, 2012;52:S25-S32. IF: 0.926
[Q4]
28. Martínez-Lapiscina EH, García MP, Alegría MB. Reply to the letter to the
editor by Lucena Romero et al on the article “Epileptic seizure and lipoma of
corpus callosum: cause or incidental finding”. Neurología. 2012;2: 58-9. IF
1,289 [Q4]
29. Martínez-González MA, García-Lopez M, Bes-Rastrollo M, Toledo E,
Martínez- Lapiscina EH, Vazquez Z, Benito S, Beunza JJ. Mediterranean
diet and the incidence of cardiovascular disease: A Spanish cohort. Nutr
Metab Cardiovasc Dis. 2011;21:237- 44 IF 3,875 [Q1]
30. Martínez-Lapiscina EH, García MP, Alegría MB. Epileptic seizure and
lipoma of corpus callosum: cause or incidental finding. Neurología.
2010;25:331-2. IF 1,289 [Q4]
31. Martínez-Lapiscina EH, Marçal Pimenta A, Beunza JJ, Bes-Rastrollo M, J
Alfredo Martínez J, Martínez-González MA. Nut consumption and incidence
of hypertension: the SUN prospective cohort. Nutr Metab Cardiovasc Dis.
2010;20:359-65. IF 3,875 [Q1]
32. Martínez-Lapiscina EH, Martínez-González MA, Guillén-Grima F, Olmo N,
Zarranz- Ventura J, Moreno-Montañés J. Dietary fat intake and incidence of
cataracts: The SUN Prospective study in the cohort of Navarra, Spain. Med
Clin 2010;134:194-201. IF 1,252 (Q3)
B) BOOK CHAPTERS
1. Martínez-Lapiscina EH, Bernardo Sánchez-Dalmau, Pablo Villoslada. Drug
Trials in Neuroprotection. Axel Petzold: Optical Coherence Tomography in
6 Elena H Martínez-­‐Lapiscina MD PhD November 30th 2015 Multiple Sclerosis. First edition. Springer International Publishing. DOI
10.1007/978-3-319-20970-8_12. Print ISBN 978-3-319-20969-2. Online ISBN:
978-3-319-20970-8
2. Martínez-Lapiscina EH, Bernardo Sánchez-Dalmau, Pablo Villoslada. Retinal
inflammation in multiple sclerosis revealed by optical coherence tomography
and ophthalmoscopy. Peter A. Calabresi, Laura J. Balcer and Elliot M. Frohman
Optical Coherence Tomography in Neurologic Diseases. First Edition.
Hardback. ISBN-13: 9781107041301
3. Martínez-Lapiscina EH, Toledo J, Martínez-González MA. Enfermedades
neurodegenerativas. En Martínez- González MA. Conceptos de salud pública y
estrategia preventiva. Primera edición. Elsevier. 2013 ISBN: 978-8480869041
4. Martínez-Lapiscina EH. Pulido Fontes L. Erro Aguirre ME Jericó-Pascual. El
músculo y la unión neuromuscular. En Sancho Rieger J, Rodríguez-Antigüedad
Zarranz A, Murie Fernández M, Ramírez Moreno JM. Manual del Residente de
Neurología de la Sociedad Española de Neurología. Segunda edición. 2012.
5. Martínez-Lapiscina EH, Jon Toledo, Miguel Ángel Martínez-González.
Enfermedades Neurodegenerativas y Mentales. En Martínez-González MA,
Seguí-Gómez M, Carlos Chillerón S. Compendio de Salud Pública. Segunda
Edición .2011.ISBN 978-84-92-870-33-2
6. Martínez-Lapiscina EH, Estefanía Toledo, Miguel Ángel Martínez-González.
Repaso de Conceptos Básicos de Epidemiología. En Martínez-González MA,
Seguí-Gómez M, Carlos Chillerón S. Compendio de Salud Pública. Segunda
Edición.2011.ISBN 978-84-92-870-33-2
C) BOOKS
Martínez-Lapiscina EH. Manual Curso Intensivo MIR Asturias Farmacología
First Edition (2010 DL AS-1823-2010) Second Edition (2011 ISBN 978-84-6944483-2) Third Edition (2012 ISBN 978-84-695-4150-0) Fourth Edition (ISBN
978-84-697-0382-3).
D) RESEARCH SUPPORT
Title: Assessment of axonal damage in Multiple Sclerosis patients by using
visual pathway neuroimaging modalities "Estudio del daño axonal en Esclerosis
Múltiple mediante estudios de neuroimagen de la vía óptica".
Financial Entity Sciences and Innovation Minister "Ministerio de Ciencia e
Innovación". Fondo de Investigaciones Sanitarias
Duration 01 January 2016 - 31 December 2019
Role: Investigator
Budget: € 110,715
Title: Retinal Neurodegeneration to track Disability in Multiple Sclerosis.
Financial Entity Ministerio de Ciencia e Innovación. Fondo de Investigaciones
Sanitarias
Duration 01 July 2016 -30 September 2016
Role: Principal Investigator [Stage to be performed at UCSF, CA, US]
Budget: € 6,000
Title: Molecular imaging of the retina in patients with Multiple Sclerosis by
Raman Spectroscopy
Financial Entity: Fundació La Marató TV3
7 Elena H Martínez-­‐Lapiscina MD PhD November 30th 2015 Duration 01 April 2015 - 31 March 2018
Role: Principal Investigator and Coordinator (multicentric)
Budget: €300,000
Title: Molecular imaging of the retina in patients with Multiple Sclerosis taking
Tecfidera® by using a Raman Spectrofotometer CMSmera coupled to Scanning
Laser Ophthalmoscope.
Financial Entity: Biogen
Duration 01 January 2015 - 31 December 2016
Role: Investigator
Budget: €60,000
Title: Mediterrean Diet to prevent dementia: an efficient initiative for the XXI
public health challenge "Prevención de la demencia con dieta mediterránea:
una iniciativa eficiente de salud pública para el reto del siglo XXI"
Financial Entity: Fundación Caja Navarra
Duration 01 June 2014 - 01 June 2015
Role: Investigator
Budget: €27.000
Title: Decision making process brain mapping, neuroeconomy in Multiple
Sclerosis "Mapeo Cerebral de los procesos de toma de decisiones
(Neuroeconomía) en Esclerosis Múltiple"
Financial Entity: Fundación Genzyme
Duration 01 January 2013 - 31 December 2014
Role: Investigator
Budget: €10.000
Title: Development of a Raman Spectrophotometer Camera for molecular
imaging of the retina in patients with retinal and brain diseases
Financial Entity: AGAUR (Generalitat de Catalunya)
Duration 01 January 2012 - 31 December 2013
Role: Investigator
Budget: €197.720,80.
Title: Mediterranean diet and cognitive function: PREDIMED-NAVARRA
randomized clinical trial "Patrón de dieta y función cognitiva en el ensayo de
campo PREDIMED AP-UNAV"
Financial Entity: Departamento de Salud del Gobierno de Navarra
Duration 01 January 2012 - 31 December 2013
Role: Investigator
Budget: €30.017
Title: Role of diet and physical activity on quality of life and mental illness in the
SUN [Seguimiento Universidad de Navarra] cohort study "Papel de la dieta y la
actividad física sobre la calidad de vida y la enfermedad mental en el estudio
SUN"
Financial Entity: Ministerio de Ciencia e Innovación. Fondo de Investigaciones
Sanitarias
Duration 01 January 2009 - 31 December 2011
8 Elena H Martínez-­‐Lapiscina MD PhD November 30th 2015 Role: Investigator
Title: Multiple Sclerosis Spanish Network "Red Española de Esclerosis Múltiple"
Financial Entity: Ministerio de Ciencia e Innovación. Fondo de Investigaciones
Sanitarias RD07/0060/0001
Duration 01 January 2008 - 31 December 2012
Role: Investigator
Budget: €131.576
Title: Multiple Sclerosis Spanish Network "Red Española de Esclerosis Múltiple"
Financial Entity: Ministerio de Ciencia e Innovación. Fondo de Investigaciones
Sanitarias RD12/0032/0001
Duration 01 January 2008 - 31 December 2012
Role: Investigator
Budget: €131.576
C) INVITED LECTURES
Meeting: LXVII Spanish Neurological Society
Organizer: Neuroimage Group of Spanish Neurological Society
Location and Date: Valencia, Spain 17-21 November 2014
Title: Photonic-based devices, Optical Coherence Tomography and Raman
Spectroscopy, technological opportunities to CNS burden assessment.
Meeting: Epigenetic and Immunology in Multiple Sclerosis
Organizer: Biogen Idec®
Location and Date: Valencia, Spain 24 June 2015.
Title: Multiple Sclerosis Disease Progression
Meeting: EM Forum
Organizer: Biogen Idec®
Location and Date: Barcelona 5 June 2015
Title: Role of MRI in the disease progression assessment
Meeting: Magnetic Resonance Imaging and Multiple Sclerosis
Organizer: Catalan Society of Neurology
Location and Date: Barcelona 5 and 19 May 2015
Title: Role of Diffusion Weighted Imaging and Spectroscopy in Multiple
Sclerosis
Meeting: 1st International Joint Conference of Catalan Society of Neurology and
Organizer: Polish Neurological Society
Location and Date: Krakow, Poland 12-13 March 2015
Title: MRI measures of neurodegeneration in multiple sclerosis
Meeting: LXVI Spanish Neurological Society
Organizer: Neuroimage Group of Spanish Neurological Society
Location and Date: Valencia, Spain 18-22 November 2014
Title: How to prepare a neuroimaging research project
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