ostim - bewege

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ostim - bewege
FOLD_OSTIM_E_0307_FINAL
08.03.2007
9:00 Uhr
Seite 1
Product Characteristics
Resorption
OSTIM® 35
The degradability of OSTIM® in the organism is based
on its nanocrystalline structure.
Viscosity
CONTENT
1 ml
2 ml
5 ml
10 ml
OSTIM® does not harden and will thus be rapidly
resorbed by macrophages and osteoclasts. Fixation
of the defect is provided as usual with commonly
used osteosynthesis measures.
Bone & Tissue Regeneration
PACKAGING UNIT
1 x 1ml
1 x 2ml
1 x 5ml
2 x 5ml
ART. NO.
235101
235102
235105
235110
Vascularization
Due to early vascularization, detectable after
7-10 days, cells can migrate into the OSTIM® matrix,
resorb it and in parallel develop new bone.
Osteogenesis
OSTIM® accelerates the rate of proliferation of bone
formation cells and stimulates bone healing.
Bone formation occurs very fast. After a few months
already, OSTIM® is completely resorbed; the bony
restructuring of the defect is complete and stable.
Primary stability
Ostim®
1.
a
innovative nanocristalline hydroxyapatite
a
its viscosity leads to a fast vascularization
a
close contact to the surrounding bone layer
a
ready to use
a
suitable as a bone graft extender
a
manufactured completely synthetically
a
stimulates bone healing
a
fully biodegradable after implantation
Load-bearing mechanical stability will be achieved –
as with other bone substitution materials – through
suitable osteosynthesis methods.
Ostim®
2.
Defect with Ostim®
Plain defect
s Your local partner:
Orders via
s
Fon +49 6071 929-0
Fax +49 6071 929-100
1. Ostim® 4 weeks post-op – Overview
(rabbits)
Responsible manufacturer
3.
s
aap Biomaterials GmbH & Co. KG
Lagerstraße 11-15 • 64807 Dieburg
Germany
Fon +49 6071 929-0
Fax +49 6071 929-100
[email protected]
WM 2004-21 / 0307
[email protected]
2. Bone trabeculae – Detailed picture
(rabbits)
3. Bone regeneration completed after 60 days
(Tibial plateau/sheep)
aap Biomaterials GmbH & Co. KG
Lagerstraße 11-15 • 64807 Dieburg
Germany
®
OSTIM
35
m Nano-particular hydroxyapatite paste
OSTIM®
FOLD_OSTIM_E_0307_FINAL
08.03.2007
9:00 Uhr
Seite 2
Exemplary Cases
Application
OSTIM® is a ready-for-use, injectable, pasty bone
matrix. It consists of a fully synthetic, phase pure and
nanoparticular hydroxyapatite.
OSTIM® is suitable for defect filling for fractures in the cancellous bone area. After repositioning of the joint surfaces and mechanical stabilization, the defect will be filled up with OSTIM® .
Due to its pasty characteristics, OSTIM® is rapidly converted into bone. Complete bone formation is already visible after a few months.
OSTIM® is used for the filling or reconstruction of
bone defects.
Take the OSTIM® syringe from the double sterile
package and apply the paste directly into the bone
defect or by means of applicators.
OSTIM® does not harden after mixing with blood or
spongiosa and is thus excellently suitable for the
augmentation of autologous or homologous material.
Tibial plateau fracture
Distal fracture of the radius
Top: prae op
Top right: prae op
Center from left to right:
post op
11 months post-op
Center from left to right:
3 month post op
6 month post op
Figure 1:
Bone biopsy from the tibial plateau,
11 months post-op at the time of
fixation removal.
Figures 2 and 3:
Bone biopsy from the distal radius,
6 months post-op at the time of
fixation removal.
The volume stability of OSTIM® 35 puts up
resistance to the haemorrhaging pressure; at the same
time, its viscosity allows the form-fitting application
with close contact to the host bone.
Indications:
Metaphysial fractures and cysts
Acetabulum reconstruction and periprosthetic
fractures with hip joint replacement surgery
Osteotomies
Filling of cages in spinal surgery
Combination with autologous
and allogenic cancellous bone
Defect filling in children
TEM presentation of Ostim® crystals.
The needle-shaped crystals correspond in size
with the natural hydroxyapatite crystals in
the human bone.
1.
2.
Newly formed bone tissue with incorporated Ostim® particles.
3.