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More than just iNO... INOMAX Total Care
TM When moments count, count on the trusted total service package that delivers uninterrupted support for INOMAX® (nitric oxide) for inhalaAon INOMAX® Indica5on INOMAX is a vasodilator, which, in conjuncAon with venAlatory support and other appropriate agents, is indicated for the treatment of term and near-­‐term (>34 weeks) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension, where it improves oxygenaAon and reduces the need for extracorporeal membrane oxygenaAon. UAlize addiAonal therapies to maximize oxygen delivery with validated venAlaAon systems. Please see Full Prescribing Informa5on at www.inomax.com/full-­‐pi. INOMAX® Important Safety Informa5on • 
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INOMAX is contraindicated in the treatment of neonates known to be dependent on right-­‐to-­‐leM shunAng of blood Abrupt disconAnuaAon of INOMAX may lead to increasing pulmonary artery pressure and worsening oxygenaAon even in neonates with no apparent response to nitric oxide for inhalaAon Methemoglobinemia and NO2 levels are dose dependent. Nitric oxide donor compounds may have an addiAve effect with INOMAX on the risk of developing methemoglobinemia. Nitrogen dioxide may cause airway inflammaAon and damage to lung Assues In paAents with pre-­‐exisAng leM ventricular dysfuncAon, INOMAX may increase pulmonary capillary wedge pressure leading to pulmonary edema Monitor for PaO2, methemoglobin, and inspired NO2 during INOMAX administraAon Use only with an INOMAX DSIR®, INOmax® DS, or INOvent® operated by trained personnel Please see Full Prescribing Informa5on at www.inomax.com/full-­‐pi. Wherever you need it INOMAX Total Care delivers •  A dependable supply of INOMAX® •  State-­‐of-­‐the-­‐art bedside and transport delivery systems •  Extensive compaAbility with over 59 venAlaAon systems, including HFOV and noninvasive modaliAes* *For instrucAons on use of specific venAlaAon systems, please refer to the INOmax DSIR® OperaAon Manual. Whenever you need it most, emergencies included Our services include •  Emergency deliveries of INOMAX® cylinders, delivery systems, and support components, most oMen within 4 to 6 hours •  Regional support centers across the country to facilitate rapid response •  AddiAonal delivery systems provided to ensure adequate supply in your hospital when you need it 24/7 access to expert support and training We offer •  Round-­‐the-­‐clock technical service and support to facilitate emergency deliveries and troubleshoot specific issues •  On-­‐site training and educaAon to serve you on your schedule—not ours •  Access to knowledgeable medical service professionals Reliability and performance that only IKARIA® can provide Our legacy of trusted performance includes •  Over 12 years of experience in criAcal care seangs •  More than 530,000 paAents treated with INOMAX® worldwide1 •  The only FDA-­‐inspected nitric oxide drug manufacturing faciliAes in the United States •  Ongoing investments in clinical research and device enhancements Reference: 1. Data on file. Hampton, NJ: Ikaria, Inc; 2013. The only comprehensive iNO therapy service package • 
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Wherever you need it Whenever you need it most, emergencies included 24/7 access to expert support and training Reliability and performance that only IKARIA® can provide Count on INOMAX Total Care™ to deliver uninterrupted support for INOMAX® (nitric oxide) for inhala5on INOMAX Total Care™ is a trademark and INOvent®, INOMAX®, and DSIR® are registered trademarks of INO TherapeuAcs LLC. www.inomax.com © 2013 Ikaria, Inc. IMK111-­‐01543 March 2013