Buyers Guide - American Academy of Anti

Transcription

Buyers Guide
DIrecTory
◗ unplugging cancer’s power supply
188
◗ IoNIc currents: The sparK of lIfe
198
◗ flaxseed for heart-healthy nutrition
208
◗ fucose complexes, fucoxanthin,
fucoid and fat storage
◗ Product Announcements
214
191
Vendors by Category
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Aesthetic Medical Treatments
206
Alternative Therapies
210
Compounding Pharmacies
212
Computer / EMR
212
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212
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218
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218
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220
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220
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222
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224
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226
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INTroDucTIoN
Unplugging
CANCER’S
POWER SUPPLY
By Maureen Pelletier, MD, CCN, FACOG
Dr. Otto Warburg was awarded
the Nobel Prize more than 70 years
ago for his discovery that cancer cells
use glucose at a rate 10 to 50 times
higher than healthy cells through
direct glycolysis via non-oxidative
pathways.1 Called “the Warburg
Effect,” this characteristic hypermetabolic activity fuels the explosive
growth of cancer, steals glucose from
healthy tissue and produces metabolic byproducts that contribute to
systemic illness. Warburg theorized
that if the uptake of glucose into
cancer cells could be inhibited, their
energy supply could be choked off,
slowing or stopping cancer growth
and forcing cancer cells to die.
A few years later, Hungarian biochemist Dr. Albert Szent-Gyorgyi,
also a Nobel Laureate, began seeking
the explanation for low rates of cancer among populations that consume
substantial amounts of whole-grain
products, compared to populations that don’t. By the early 1980s,
Szent-Gyorgyi had isolated natural
compounds within wheat germ that
he believed would have anti-cancer
properties if consumed in supplemental amounts.2
Recent research has linked the
findings of these two Nobel Laureates: A unique fermented wheatgerm extract (FWGE) blocks glucose
uptake within cancer cells, choking
off their energy supply, reducing
their ability to grow and proliferate,
and eventually causing cancer cell
death by apoptosis, without any detrimental effect to healthy cells.
seeKINg sTable TargeTs
The limitations of conventional
cytotoxic anti-cancer treatments
such as radiation and chemotherapy
are clear. They are lethal to both
cancerous and healthy cells, so they
produce highly undesirable side effects up to and including raising the
risk of future cancers. These shortcomings led to the development of
targeted therapies (i.e., smart drugs)
that inhibit molecular targets present
continued on next page
188 ❘
ANTI-AGING MEDICAL NEWS
SUMMER 2008
Unplugging Cancer’s Power Supply continued from page 188
or overabundant only in cancer cells.
However, the initial exuberance over
the early successes of these targeted
therapies has been balanced in recent
years by the discovery that the mutated
genes which produce such molecular
targets continue to mutate over time.
This means the molecular targets assume new shapes over time and are no
longer affected by drugs designed to
bind to an earlier, original version of the
target.3-5
Targets offered by the Warburg Effect
are very different. They are not the
result of mutated genes. Instead, they
are simply enzymes upon which cancer
cells are far more dependent than are
normal cells. These enzyme targets are
stable over time; essential to tumor cell
growth, survival and proliferation; and
are present in virtually all cancers. The
opportunity to focus effectively on such
targets has existed in theory for some
time, but has become a reality only in
recent years, as the tools of modern science have caught up with the wisdom
and intuition of visionaries from threequarters of a century ago.
New Tools Illuminate Warburg
Effect Metabolic Targets
Dr. Warburg noted in his Nobel acceptance speech that fully understanding cell metabolism was extremely
difficult because of the fast and shortlived nature and overwhelming number of chemical reactions that make up
metabolic pathways.6 He knew what
happened – that cancer cells used large
amounts of glucose to thrive – but he
didn’t know the biochemical details of
exactly how they did so.
In the mid- and late-1990s, researchers developed sophisticated new tools
for studying metabolic reactions in
cells in precise detail.7 One such technique, called stable isotope-based dynamic metabolic profiling (SiDMAP),
uses glucose tagged with special, heavy
isotopes of carbon (C-13) to trace the
use of glucose in the synthesis of RNA,
DNA and fatty acids. The technique
identifies which key metabolic chemicals can be used as targets – targets
that if blocked can thwart cancer cells’
SUMMER 2008 ability to obtain energy or to make the
DNA necessary to replicate.
FWGE Inhibits Warburg-Effect
Metabolism
The SiDMAP technique of metabolic
profiling was applied to understanding
how Szent-Gyorgyi’s fermented wheatgerm extract (FWGE) affected metabolism in MIA pancreatic cancer cells.
SiDMAP showed that pancreatic cancer
cells utilized vast amounts of glucose
for the carbon atoms they contain. The
Warburg Effect in these cells bypasses
the slower oxygen-dependent pathways
of normal cells. Pancreatic cancer cells
utilize the non-oxidative transketolase
(TK) enzyme pathway, incorporating
carbon atoms from glucose to make ribose, the sugar that forms the backbone
of RNA and DNA required for cancer
cell proliferation and tumor metastasis.8
The FWGE produced a radical, dosedependent inhibition of transketolase
(TK), slowing glucose uptake into
pancreatic cancer cells and inhibiting
the cells’ synthesis of RNA. At the same
time, FWGE increased direct glucose
oxidation and ribose recycling in the
pentose cycle – hallmarks of normal
cell metabolism. The cancer cells were
forced to revert to the metabolic pathways used by normal cells, using glucose
more for production of fatty acids and
cell-structure components and less for
ribose. These metabolic shifts promoted
cell differentiation to normal cell phenotypes in some cells, and caused death
by apoptosis in other cancer cells.9
FWGE has been shown to have
similar results with many other types
of cancer. In a study with Jurkat leukemia, cells were treated with increasing amounts of FWGE for 48 and 72
hours.10 TK activity was inhibited by
more than 50 percent in two days and
by more than 90 percent in three days.
Glucose carbons going into new nucleic
acids so new cancer cells could be made
were reduced by 40.2 percent, reducing
cell proliferation. The leukemia cells’
ability to obtain energy was inhibited by
over 95 percent in 48 hours by FWGE
inhibition of the activity of hexokinase,
an enzyme key to energy production
via glycolysis. Simultaneous inhibition
of enzymes key to both oxidative and
non-oxidative glucose utilization led to
apoptosis.
FWGE also inhibited the enzyme
glucose-6-phosphate dehydrogenase
(G6PDH), a metabolic enzyme essential for using glucose carbons to
make ribose through another pathway.
G6PDH levels fell by more than 90
percent in three days at a dose of 0.5
mg/ml of FWGE, and by more than 95
percent in a shorter time with a higher
dose. This showed an ability of the
FWGE to virtually eliminate cancer
cell proliferation through inhibition
of both major and minor pathways of
cancer cell synthesis of ribose.11
Further evidence that the anti-cancer
effect of FWGE is not dependent
on the cancer type was illustrated in
experiments with estrogen-sensitive
(ER+) and estrogen-negative (ER-)
breast cancers. Tumor lines from mice
and from humans were implanted in
female mice. FWGE inhibited ER+
tumors by 50 percent, better than
the 42 percent inhibition rate for the
tamoxifen, 26 percent for exemestane
and 25 percent for anatrozole. On the
ER- cancers, the anti-estrogenic drugs
tamoxifen, exemestane and anatrozole
have been shown to be ineffective, but
FWGE was just as effective, inhibiting
tumor gowth by 52 percent.12 Because FWGE inhibited growth of both
estrogen-sensitive (ER+) and estrogenindependent (ER-) tumors equally, the
data suggest it was the restriction of
the Warburg Effect’s glucose uptake
for energy and cell replication that was
responsible, rather than interference
with estrogen activity.
Clinical Anti-Cancer Effects of
FWGE Inhibition of Warburg-Effect
Metabolism
Proof of the principle that FWGE can
inhibit cancers by targeting the Warburg
Effect has been shown in many in vivo and
in vitro experiments and has shown promise in clinical trials.
In a multicenter clinical trial involving
170 patients with colorectal cancer, FWGE
continued on page 190
❘ 189
Unplugging Cancer’s Power Supply continued from page 189
reduced the risk of death by almost 70
percent.13 The 66 patients taking supplemental quantities of FWGE had improved
overall survival compared to controls (12.1
percent deaths vs. 31.7 percent); far fewer
recurrences (3.0 percent vs. 17.3 percent)
and far fewer metastases (7.6 percent
vs. 23.1 percent). FWGE’s inhibition of
glucose uptake and use of glucose carbons
to synthesize ribose for DNA for proliferation were significant factors in the slower
disease progression and increased survival.
As a result of these and other findings,
FWGE is now part of the standard of care
for colorectal cancer in Hungary, where
FWGE is approved as a medical nutriment
in support of patients undergoing treatment.
Clinical studies of FWGE in squamous
cell cancers of the head and neck
(SCHNN) led a European surgeons association specializing in head and neck
cancers to approve a recommendation that
FWGE be a routine part of the standard of
care for treatment of all such cancers.14
In the first study, 50 head and neck
cancer patients were treated with
surgery, chemotherapy and/or radiotherapy, with or without the addition of
FWGE. Three years later, the majority of
those receiving FWGE, including five of
six with advanced salivary gland cancer,
had no new recurrences or metastasis.
Benefits of conventional treatments were
enhanced by FWGE, and side effects were
reduced. Patients on FWGE gained appetite, weight and strength.
In the second study, involving 45 adults
with stage II or stage III cancers of the
mouth, addition of FWGE to surgery,
chemotherapy and radiation reduced the
risk of the cancer progressing to a more
advanced stage by 85.3 percent, mainly by
reducing risk of metastasis (spread). At five
years, 74 percent of FWGE patients were
alive, compared to 45.5 percent of patients
getting only conventional treatment.
In the third study, Italian researchers
found that 60 days of FWGE after surgery
and other conventional treatment for
advanced head and neck cancer patients
(stages III and IV) improved the patients’
quality of life (Spitzer QOL index), lowered oxidative stress and prevented weight
loss in the 22 who got FWGE, compared
to the 33 who didn’t. This led researchers
to report FWGE as having a pivotal benefit
190 ❘
in the treatment of patients with advanced
head and neck cancers.
FWGE has been shown to slow disease
progression in stage III melanoma patients15 and to improve quality of life and
relieve fatigue in advanced lung cancer.
2. Szent-Gyorgyi A. Int J Quantum Chem Quantum Biol
Symp, 1982;9:27-30.
Conclusion
4. Kwak EL, Sordella R, Bell DW, et al. Irreversible inhibitors of the EGF receptor may circumvent acquired
resistance to gefitinib. Proc Natl Acad Sci U S A, 2005
May 24;102(21):7665-70.
The data from clinical studies of
FWGE show improved overall survival,
improved disease-free survival, and
improved quality of life with no undesirable effects on healthy tissue. These
benefits make it clear that targeting the
mechanisms of Warburg-Effect metabolism, which is restricted to cancer cells,
provides unique opportunities to benefit
patients without the undesirable side
effects characteristic of cytotoxic cancer
therapies, and without the narrow applicability and target slippage of “smart”
synthetic drugs. The incredibly innovative and insightful cancer research begun
by another century’s brightest scientists
has come full circle. We now know not
just that Warburg and Szent-Gyorgyi
were right, but also why. We can see how
cancer patients have benefited from the
work of these geniuses, and how and
why they are likely to continue to do so.
Currently, fermented wheat-germ
extract is available as the medical
nutriment Avemar® from Biropharma
of Budapest, Hungary, and as the
nutritional supplement AvéTM, from
American Biosciences of Blauvelt, N.Y.
(1-888-884-7770). Additional research
on FWGE can be viewed at www.
pubmed.gov using the search term “fermented wheat germ” and at
www.avemarresearch. u
REFERENCES
3. Fabarius A, Haferlach C, Muller MC, et al. Dynamics
of cytogenetic aberrations in Philadelphia chromosome positive and negative hematopoiesis during
dasatinib therapy of chronic myeloid leukemia
patients after imatinib failure. Haematologica, 2007
Jun;92(6):834-7.
5. Haber DA, Bell DW, Sordella R, et al. Molecular targeted therapy of lung cancer: EGFR mutations and
response to EGFR inhibitors. Cold Spring Harb Symp
Quant Biol, 2005;70:419-26.
6. http://nobelprize.org/nobel_prizes/medicine/laureates/1931/press.html.
7. Lee WN, Boros LG, Puigjaner J, et al. Mass isotopomer
study of the nonoxidative pathways of the pentose
cycle with [1,2-13C2] glucose. Am J Physiol, 1998
May;274(5 Pt 1):E843-51.
8. Boros LG, Lapis K, Szende B, et al. Wheat-germ
extract decreases glucose uptake and RNA ribose
formation but increases fatty acid synthesis in MIA
pancreatic adenocarcinoma cells. Pancreas, 2001
Aug;23(2):141-7.
9. Ibid.
10. Comin-Anduix B, Boros LG, Marin S, et al. Fermented wheat-germ extract inhibits glycolysis/
pentose cycle enzymes and induces apoptosis through
poly(ADP-ribose) polymerase activation in Jurkat
T-cell leukemia tumor cells. J Biol Chem, 2002 Nov
29;277(48):46408-14.
11. Ibid.
12. Telekes A, Tejeda M, Szcs I, et al. Avemar inhibits
growth of mouse and human xenograft mammary
carcinomas comparably to endocrine treatments.
American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, 2007.
13. Jakab F, Shoenfeld Y, Balogh A, et al. A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer, 2003 Aug 4;89(3):465-9.
14. Barabas J, Nemeth Z. [Recommendation of the Hungarian Society for Face, Mandible and Oral Surgery in
the indication of supportive therapy with Avemar.]
Orv Hetil, 2006 Sep 3;147(35):1709-11.
15. Demidov LV, et al. Anti-metastatic effect of Avemar
in high-risk melanoma patients. 18th UICC International Cancer Congress, Oslo, Norway, June 30-July 5,
2002. Int J Cancer, 2002;100(S13);408.
1. Xu RH, Pelicano H, Zhou Y, et al. Inhibition of
glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial
respiratory defect and hypoxia. Cancer Res, 2005 Jan
15;65(2):61.
◗ Maureen Pelletier, MD, CCN, FACOG
Dr. Pelletier is a lecturer, author and the Director of Functional Medicine
at the LaValle Metabolic Institute in Cincinnati, OH. She specializes in hormone replacement, men’s and women’s health, and is a Defeat Autism
Now (DAN!) physician.
SUMMER 2008
PRODUCT Announcements
◗ Tinted Moisturizer Protects Against UVA/UVB Rays
jane iredale introduces Dream Tint™, an oil-free formula that provides lightweight coverage and instant UVA/UVB SPF 15 protection. This tinted moisturizer can also be layered
underneath a mineral base as an effective skin primer. Dream Tint™ glides on effortlessly and is easily absorbed for a no-mess, trouble-free application leaving a silky,
flawless finish.
The active ingredient in Dream Tint™ is titanium dioxide. It also contains boron
nitride, which helps to minimize the appearance of fine lines and pores and sea lipids
that help to improve skin’s elasticity and prevent trans-epidermal water loss.
This multipurpose product is available in five shades ranging from Light to Dark, to
complement any complexion.
jane iredale products can be purchased at the company’s web site and at select locations.
Retail Price: $36
For more information:
(800) 762-1132
www.janeiredale.com
◗ Age Intervention® Enlighten
Age Intervention® Enlighten, a remarkable new composition that brightens and encourages the uniform appearance of facial discoloration.
Overly pigmented facial areas that may occur due to melasma, cumulative sun exposure
and ethnicity are some of the most common and difficult concerns to treat.
Enlighten contains a combination of two exceptional topical agents that address the
appearance of facial discoloration. Enlighten also includes Retinol, a superior retinoid that
discourages the production of excess melanin and assists in resolving the appearance of
existing facial discoloration.
Enlighten’s exceptional brightening technology and de-aging agents result in refined and
illuminated skin.
For more information contact Jan Marini Skin Research at 1-800-347-2223 or
visit www.janmarini.com
◗ SUGARSolve 24/7™ for Healthy Blood Glucose Levels
SUGARSolve 24/7, from American BioSciences, addresses the classic symptoms of blood sugar concerns, including low energy, mood swings and tough-to-lose weight, by safely and naturally
helping to normalize blood sugar levels. SUGARSolve 24/7 contains an extract from the Banaba
leaf (Lagerstroemia speciosa L.), standardized to 18% corosolic acid, which is clinically proven to
activate cellular glucose transport. Research indicates that high-dose corosolic acid may increase
the activity of facilitative glucose transporters, specifically GLUT4, which is located in fat tissue,
heart and skeletal muscle. This carrier-mediated process leads to more efficient utilization of
glucose and is the natural way to help stabilize blood sugar levels.
For literature and research, contact: American BioSciences, Inc, Blauvelt, NY,
(888) 884-7770, www.americanbiosciences.com.
SUMMER 2008
❘ 191
◗ PolyDerm
PolyDerm is a uniquely formulated proprietary blend of Palladium Lipoic Complex designed to protect, enhance and support cellular energy production and
promote total health. PolyDerm comes in a 4 oz bottle with a pump and offers a
powerful antioxidant via a transdermal method of delivery. Uses include anti-aging,
oxidation, wrinkles and youthful skin.
For more information, contact AMARC Enterprises at 866-765-9682 or visit www.polymva.com.
◗ Oxygen Anti-Aging Cream
Vinoy Oxygen Anti-Aging Cream is a world-patented product
from Germany for facial skin rejuvenation! This Cream combines
Oxygen with over 20 of the finest European plant extracts and
nutrients for your skin. This extraordinary Cream has remarkable
healing, anti-inflammatory and skin rejuvenating effects!
Vinoy Oxygen Cream protects the skin from harmful environmental free radicals and from the effects of aging and sun damage.
With its unique formula and world-patented Oxygen delivery
system, this Cream revitalizes and rejuvenates the skin at a deep
cellular level!
This Oxygen Cream significantly diminishes wrinkles and age
spots and increases skin elasticity, hydration, collagen and elastin.
This exquisite Cream restores a luminous, youthful glow to the
skin. Vinoy Oxygen Cream is beauty and vitality for your face!
Vinoy Oxygen Anti-Aging Cream is exclusively available and distributed in
the United States through:
International Wellness Clinic
240 Conestoga Road, Wayne, PA 19087
Telephone: 610-971-9355
Website: www.internationalwellnessclinic.com
e-Mail: [email protected]
◗ T’Fivve Ideal Age-defying Regimen
Specially formulated for skin types sensitive to existing,
traditional anti-wrinkle ingredients and infused with breakthrough, patented ingredients called “ K6PC5 and Ascorbyl
pentapeptide”
Clinically proven to have very effective anti-wrinkle and
anti-oxidant effects for dry and sensitive skin. 72% of participants said it was effective for minimizing fine lines and
wrinkles in just 8 weeks What is more terrific is that it causes
NO side-effects like dryness, irritation, hyperplasia and skin
damage that can easily arise by traditional anti-aging ingredients.100% of participants experienced no product sensitivity
at all and 88% experienced a decrease in existing skin problems. While, 88% said it made their skin feel suppler
For more information contact Skin Scientifica Inc, Englewood Cliffs,
New Jersey (201) 944-7443, www.tfivve.com
192 ❘
[8 weeks results, from clinical tests]
SUMMER 2008
◗ MicrodermaMitt Face Mitt and Body Mitt
MicrodermaMitt, Inc. is a 3+ year old company based in Cincinnati, Ohio. Our
main product line is a unique, all natural deep exfoliating mitt (MicrodermaMitt Face
Mitt, Body Mitt). By lifting and removing the top layer of dry or dead skin cells, the
mitts instantly reveal smoother and more radiant skin unlike any other exfoliating
product on the market. The mitt also smoothes keratosis pilaris instantly, helps treat
and prevent acne and helps prevent ingrown hair. No creams, chemicals or additives
are used on the mitt. Made of all natural floss silk, it works with only water to create
a gentle friction with the skin. The mitts are effective on all skin types, including
sensitive skin.
Our products are currently sold in Spas, Medi-Spas, Dermatologists, Laser, Plastic
Surgeons and other Physician Offices as well as venues that promote healthy skin.
MicrodermaMitt, Inc.
P.O. Box 43177
Cincinnati, OH 45243
Toll Free 866-4550-(MITT) 6488
Website: www.microdermamitt.com
Email: [email protected]
◗ Power Plate®
Power Plate® machines are a revolutionary modality that offers healthcare practitioners an adjunct method to treat their patients. Using Acceleration Vibration Technology™ Power Plate® machines stimulate your
body’s natural response to vibrations to help improve muscle endurance,
stimulate circulation and performance. The whole body vibration technology behind Power Plate® machines is appropriate for the treatment of
various ailments afflicting an aging population, addressing conditions ranging from debilitating illness to cosmetic issues. Benefits include: cellulite
reduction, increase of metabolic functions, increase in bone mineral density,
and improved muscular tone and stability.
Power Plate Healthcare
877.87.PLATE
www.powerplatehealthcare.com
◗ Health Begins in the Colon
Inside each of us is a vast ecosystem that helps digest food and contributes to
health and well-being. These acids, enzymes and bacteria actually digest your food,
while the intestines manage the flow and absorption. Support your patients’ GI
health with:
Probiotics + FOS containing 8 clinically documented strains, 4 billion
organisms per enteric coated, shelf-stable capsule.
Digestive Enzymes is formulated to support digestion of protein (pancreatin, protease), fats (lipase), carbohydrates (alpha-amalase, amyloglucosidase), fiber (cellulose, hemicellulase), and milk sugar (lactase).
Flush! Colon Cleanse bulking hydrophilic fiber to support digestive
and eliminative functions without causing weakness or dependency.
With psyllium, flax & oat soluble fiber, and triphala to gently tone and
strengthen the colon. Also contains anise and ginger to help reduce
gas and bloating, resulting in a comprehensive approach to internal
cleansing.
Contact Rejuvenation Science® at 888-74-REJUV or
www.rejuvenation-science.com/probiotics.html or A4M booth 440
SUMMER 2008
❘ 193
◗ LipoLite™
The new evolution of laser lipolysis devices, LipoLite™ is the minimally invasive
system designed to destroy fat cells and coagulate tissue on the body and the face, cost
effectively. It is ideal for areas that are difficult to treat with traditional liposuction,
such as under the chin and upper arms.
LipoLite is offered at a special introductory price making it easier for you to equip
your practice to meet rapidly expanding demand for liposuction-like body shaping –
the most popular aesthetic procedure today.
LipoLite features OptiPulse™ – precision control over both the pulse energy and
repetition rate to optimize both the photo-mechanical and photo-thermal destruction
of the adipose tissue more effectively.
An efficient, compact system, LipoLite fits easily into any office environment or
operating theater, where space can be at a premium. LipoLite weighs only 44 pounds,
so it can be easily moved from room to room or between offices.
Designed with future upgradability in mind, LipoLite is a surgical platform that will
continue to grow as your practice expands.
For more information contact: Syneron, Irvine California (949) 716-6670, www.syneron.com
◗ VelaShape™
VelaShape™ is the first and only non-surgical FDA-cleared medical device for the
Body Reshaping market and the first FDA class II cleared platform for Cellulite Treatment featuring the revolutionary elōs™ technology that enables you to comfortably
achieve a toned, contoured and well shaped body.
VelaShape™ is the only proven device with breakthrough results as it treats both
the deeper tissue and the upper layers of the skin. This results in a measurable reduction in fat layers, circumference and the appearance of cellulite. VelaShape™ offers a
non-surgical, no downtime and virtually painless treatment for the Body Reshaping
and Cellulite Treatment market, with proven results in as few as 4 treatment sessions.
VelaShape™ advantages translate to enhanced comfort, convenience and satisfaction; giving you the opportunity to improve your lifestyle and boost your self-confidence.
For more information contact: Syneron, Irvine California (949) 716-6670, www.syneron.com
*FDA clearance for Circumference Reduction of the thighs.
◗ Frequency Specific Microcurrent
Frequency Specific Microcurrent provides a new tool to anti-aging
physicians. Microamperage current has been known for years to increase
energy production in cells and to increase the rate of healing in injured
tissue. New research confirms that frequency modulated microcurrent
reduces inflammation at a much enhanced rate over unmodulated current. Frequency Specific Seminars teaches the frequencies and clinically
documented protocols in a three day seminar using frequency specific
equipment from Precision Distributing.
Frequency Specific Seminars
877 695-7500
www.frequencyspecific.com
194 ❘
SUMMER 2008
Washing laundry with harsh chemical detergents can have an undesirable effect on anyone, particularly those who are
chemically sensitive. Unwelcome side effects include allergies, skin irritation and rashes that are caused by the dyes, phosphorous, perfumes and other allergens added to chemical detergents.
In wastewater treatment plants detergent is one of the most difficult chemicals to remove from water. The same problem
occurs when clothes are washed in detergent. The chemicals remain in the laundry and are absorbed by people through the
skin and nose, resulting in allergies, which afflict millions of Americans.
Now, with the trio T-Wave Cleaning Capsules, you can eliminate chemical
detergents and powders, as well as dryer fabric softener sheets and let your water
do the cleaning. The activated ceramics in these remarkable little capsules react
with water to increase its solvency, so it penetrates fabric and lifts out dirt without additives. The capsules last up to 700 wash loads in a top-loading machine
or 500 in a front-loading machine. Add a capful of the included Tsunami Papaya
Enzyme bleach replacement to brighten both whites and colors. Kit includes
three capsules and one 32-ounce bottle of papaya enzyme.
Remarks Lyle Hurd, publisher of totalhealth Magazine: “Our family has been
using T-Wave Laundry Capsules exclusively for more than eight years. Not only
have we avoided the numerous negatives of commercial detergents over some
2000 washings, we estimate we have saved a minimum of $300 on detergent
during that period. The laundry capsules make a great gift and should be an
imperative for pregnant women and families with young children.”
The T-Wave Laundry Capsule Kit retails for $59.95. Visit www.shop.tsunamiwave.com and
use Coupon Number “A4M-1” for a 5% discount.
◗ 3SIXTY5™ by XanGo
*3SIXTY5™ by XanGo is a superior blend of specialty nutrients that provides health benefits that support
cardiovascular health, bone and joint health for women, and prostate health for men. It also introduces the benefit of the
mangosteen fruit and whole-food phytonutrients into the multivitamin category by offering a unique daily supplement
that, in conjunction with a daily serving of XanGo Juice, will provide optimal nutrition with superior bioavailability. Each
serving of 3SIXTY5 contains four layers of health protection:
• 3SIXTY5 Daily Essentials – a complete blend of essential vitamins and minerals at optimum levels in bioavailable
forms for full absorption
• 3SIXTY5 Whole Food Blend – a blend of xanthone-rich mangosteen peel concentrate plus 12 fruits and 12
vegetables, enabling each phytonutrient to build off the good of the other elements
• 3SIXTY5 Heart Nutrition – a special blend of CoQ10, marine omega concentrate, olive oil, borage oil, organic
flaxseed oil and vitamin E
For Men:
• 3SIXTY5 Men’s Nutrition – a blend of natural
ingredients, including saw palmetto berry extract and
pumpkin seed oil, designed specifically for men’s health and
energy
For Women:
• 3SIXTY5 Bone Nutrition – a combination of highly
absorbable, chelated calcium and magnesium enhanced with
flavonoids, vitamin D, boron and other absorption-optimizing
nutrients
The mangosteen included in 3SIXTY5 is made from a
xanthone-rich mangosteen peel concentrate, so it is consistent
with the whole fruit formula featured in XanGo Juice.
For additional information on 3SIXTY5 go to www.xango.com or
www.xango365.com.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.
SUMMER 2008 ANTI-AGING MEDICAL NEWS
❘ 195
◗ T-Wave Cleaning Capsules: Cleans Clothes Without Harsh Chemicals and
Abrasive Detergents
◗ MaxNox
“No circulation, no healing, no repair, no life!”
MaxNox is a New and Proprietary formulation with NITRIC OXIDE, a natural compound which contributes to the healthy elasticity of the blood vessel walls. Major illnesses
of immune disease, diabetes, and even natural aging causes lower production of nitric oxide
& libido for both men and women. A daily intake of MaxNox can help you to actually feel
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Ionic Currents: The Spark of Life
Abstract:
Dynamics
198 ❘
thesis, the primary source of cellular energy depends
upon the driving source of electrons and protons.
Given the required amount of electrons, free radicals
(molecules with a missing electron) can be instantly
stabilized. Many clinically used drugs such as calcium
channel blockers and anaesthetics interact specifically
with ion channels. Many major pharmaceutical companies are showing increasing interest in ion channels as a
new drug target. (Young et al, 2001). However, very little research has been invested in decoding endogenous
electrical signals and the mathematical resultant of their
overall activity. It is possible to electronically resonate
the mathematical resultant of physiological energy as
pioneer Pollock (1988-2008) has recently done in his
lab by composing a pure analog multi-sine waveform
that acts as a key to a lock with muscle neurons. Such
pure analog waveform may act as a reparative force
in itself, as well as an electronic diplomat to awaken
the activation of biological reparative mechanisms involved in extended longevity.
1
Denatured: unfolded, dysfunctional, breaking of bonds (e.g. Hydrogen bonds
responsible for a protein’s highly ordered nature)
Xanya Sofra-Weiss, Ph.D
Biological
The aging process cannot be conceptualized by examining a single gene or a single pathway, but can
best be addressed at the systems level. Aging is
not only the sum total of shortened telomeres, denatured1 proteins and DNA molecules, or oxidative
damage in the mitochondria. It attacks key regulatory nodes crucial for the stability of the biological
network. Aging is the dynamic process of increasing
imbalances in the organism as a result of degenerating biological processes. The old, the ill, and the
injured all suffer from disarranged patterns of atoms.
A single substitution of an A for a G in a DNA molecule can cause a significant change in the conductance of the molecule leading to cancer. Shaklin et
al (2008) recently reported that a single substitution
in the amino acid sequence of an enzyme changed
its function into that of a theoretical distant ancestor. “It’s as if we turned back the clock nearly 2.5
billion years, to the time when oxygen first appeared
in Earth’s atmosphere, to get a snapshot of how enzymes evolved to deal with reactive oxygen species,”
said Shanklin, biochemist in the Brookhaven National Laboratory and the Karolinska Institute in Stockholm. Such research findings demonstrate how the
sequence and interrelations of amino acids in a protein, or the sequence of base pairs in a DNA molecule
can become determining factors between health and
disease, aging and youth. Research has shown that
gene expression is stronger when the gene is attached
to the nuclear envelope (the membrane that surrounds the nucleus) than when the gene moves
away from the nuclear envelope (Taddei et al, 2008).
In other words, cells make use of the nuclear architecture or spatial organization of the nucleus to
code epigenetic information. The DNA sequence
alone doesn’t determine everything. The importance
of nuclear architecture in regulating gene expression
begs for scientific observation that goes beyond the
study of atoms and molecules, i.e. the organism’s components. It is imperative that research focuses on the
interrelations, sequence, orientation and spatial organization of an organism’s atoms and molecules, i.e.
the dynamic processes that characterize the organism’s vital functions and survival. Electrical charge
is a dynamic entity emerging from opposites such as
protons and electrons attracting each other. How is
electricity related to biological processes? Recent research has shown that DNA, proteins and cells, including stem cells, appear to be electrical in that they
demonstrate conductivity or the presence of ionic
currents (Li et al, 2008; Brown et al 2008). ATP syn-
The Directional Force
for cellular metabolism
& energetics
We are aging. Why?
We used to think the answer is simple. We are born
fresh and young and eventually the system breaks down
and dies. But how about the body’s immune defenses
and self reparative and self detox mechanisms such as
the following? (1) J. Chang & Reiner (2007) found that
after the initial infection, some of the descendents of an
immune cell reacting to a microbe must become the soldiers that fight the infection and die; but some, instead,
regenerate to take the place of the mother cell, leaving
an immunologic memory to recognize the invading microbe in the future. (2) The consensus on DNA and aging is that endogenous electron transport within DNA
empowers DNA to deflect oxidative damage away from
its important sections. (3) Studies have shown that
aging is accelerated by suppressing a cellular cleanupmechanism known as autophagy engulfing damaged
cellular proteins or molecules (Finley 2003-2004). (4)
Science Daily (April 17, 2008) published an article
on a complex safety mechanism that drives damaged
cells to apoptosis (cell death). Steegborn and Wolters
(2008) identified the part of Protein p66Shc that is responsible for a cell’s suicide and they additionally ascertained the precise mechanism of its regulation. In order
for the self-destruction to be initiated, several protein
components must work together. The complex can apparently be decomposed by the cell’s repair mechanisms
SUMMER 2008
IONIC CURRENTS
T H E S PA R K O F L I F E
Biological
for precisely as long as the cell damages are repairable.
Only when the cell is defective beyond repair does it
perish. (5) Reed et al (2008) has identified a fragment of
a protein that senses chemicals that induce a cell to move
into the right direction. This protein is involved in the choreography of cell migration that is vital in the development
and survival of the organism. These are a few examples of
2
Dynamics
a vast body of studies demonstrating cellular memory
and more importantly, cellular intelligence. Research
delineates the biological system as a dynamic entity
equipped to control its destiny. Life does not appear
to be an automatic linear progression from new to old.
The cells in our bodies are not born to simply march
to their death. Could it be that aging is reversible?
Youth and aging are simple concepts, they are easy to
understand as a whole because they are easily identifiable. Everyone can distinguish a young person from
an older person no matter how much Plastic Surgery,
Botox, Fillers, Thermage and Laser treatments this
older person has had. Young and Old are simple concepts because they are dynamic wholes or Gestalts
that are greater than the components that orchestrate
them. Color white is a Gestalt because it reflects and
transmits all the wavelengths of light corresponding to our perception of all other colors, blue, green,
yellow, red. Color white is a new entity that is easily distinguished from all other colors that compose it.
Following this line of reasoning we pose the question:
“What are the components of aging?” The simple answer seems to be: the sum total of biological dysfunctions. But how does any biological dysfunction affect
the remaining normal operations of an organism -- a
disruption analogous to that caused by a car accident
in rush hour traffic? What about oxidative damage as
a result of energy production in the mitochondria or
environmental pollution, analogous to adverse weather
conditions? What about inadequate cell energy (ATP),
analogous to an electrical power shortage, shutting
down traffic lights and central computer networks? We
now know that longevity genes are like a 911 command
center that help repair biological damage like progenitor cells for example (Sinclair 2007). Progenitor cells
are like stem cells in that progenitor cells have a capacity to differentiate into a specific type of cell. In contrast to stem cells, however, progenitor cells are pushed
to differentiate only into their "target" cell. Progenitor
cells lie dormant or possess little activity in the tissue in
which they reside. They exhibit slow growth and their
main role is to replace cells lost by normal attrition. In
case of tissue injury, damaged or dead cells, progenitor
cells can be activated the way a 911 center would be
activated.
Stem Cells (ESCs) Depend on Ionic Currents
SUMMER 2008
Embryonic Stem Cells (ESCs), require specific signals
for correct differentiation. If injected directly into the
body, ESCs will differentiate into many different types
of cells, causing a teratoma (neoplasm, tumor or cancer).
Li et al (2008) from Johns Hopkins University that has
specialized in genetically engineering stem cells and has
engineered heart cells derived from human ESCs, reports that the problem with human ESC-based therapies
is the potential for engineered grafts to go haywire after
transplantation and form tumors. “We therefore decided
to explore the existence of ion channels in pluripotent,
or versatile, human ESCs because electrical activity is
known to regulate cell differentiation and proliferation,”
says Li. Li et al (2008) have discovered the presence
of functional ion channels that act like electrical wires
in human ESCs. Such research may minimize the dangers that human ESC-based therapies presently has and
may enhance longevity by transplanting unlimited supplies of healthy, specialized cells into damaged organs.
“In a number of different cell types, from cancer to Tlymphocytes, Potassium (K+) channels are responsible
for altering the membrane voltage of cells,” says Li. “We
found that blocking potassium channels in ESCs also
slowed their growth,” says Li. “Our findings may lead
to genetic strategies that suppress undesirable cell division after transplantation, not only for ESCs and their
derivatives, but perhaps for adult stem cells as well.”
DNA: The Spark of Life
Hoeijmakers et al (2008) found that mutation of the
DNA repair gene ERCC1 induced symptoms associated
with aging. They also found that accumulation of unrepaired DNA in the cellular system can contribute to normal aging. Since 1980 (Davidovitch et al) experimental
researchers have reported that nucleotides, the subunits
of DNA and RNA, seem to be intimately involved in the
cellular response to the stream of electrons. Many investigators have attempted to measure the electrical conductivity of DNA. However, it is very difficult to control all
the parameters that may affect the conductivity of DNA,
e.g., length, conformation, ionic environment, humidity,
experimental protocols, and many other factors. Inomata
et al (2007) measured the electrical conductivity of DNA
using fine electrodes with a gap of about 200 nanometers
and found that DNA contained both conducting and
insulating parts. Electrical conduction in DNA appeared
to be temperature dependent. DNA has been shown to
conduct an alternating current, but not direct currents.
The consensus is that electron transport within DNA allows DNA to deflect oxidative damage away from its
vital sections. If DNA damage is one of the primary
causes of aging, then a steady electron infusion via an
electronic device that can reinforce electron transport
within DNA may potentially enhance longevity.
Brown et al (2008) conducted a well controlled experiment where the usage of nanotubes allowed for a more
accurate measure of DNA conductivity. DNA molecules
are only 2 nanometers wide. A nanotube is as thick as
DNA. Using nanotechnology in their apparatus allowed
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3
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200 ❘
Brown et al (2008) to confirm that DNA is conductive. Brown also tested the null hypothesis by adding
an enzyme to the surrounding liquid that cuts DNA,
and as expected the electrical circuit was broken. If
one of the bases in a DNA pair is changed, however,
the two strands
will still stick together, but with
an altered structure around the
mismatched bases. The team first
measured
the
conductivity of
a well matched
strand and then
exchanged it for
a strand with a single mismatch. This single mismatch
boosted the resistance of the DNA by a factor of 300
demonstrating the need to make measurements on
duplex DNA that is well-matched, undamaged, and
in its native conformation. These results suggest that
prior contradictory evidence on DNA conductivity
may be due to methodological difficulties resulting
in DNA damage that compromised its conductivity.
Brown et al’s results (2008) on mismatched DNA
strands highlights the heightened sensitivity of the
molecular system to the slightest disorganization of
its components. It is reminiscent of atomic theorems
that one atomic arrangement can make coals; yet rearranging the atoms in a different sequence can make
diamonds. It is also reminiscent of a Gestalt principle
where the dynamic whole is transformed depending
on the arrangement of its parts. How are all these
philosophical propositions relevant to Medicine and
longevity? It introduces a perspective where the piecemeal study of biological elements is complemented
by the study of how these elements are interacting to
form a whole. Tao and Zhang (2005) found that just
a single base pair mutation in a DNA molecule, such
as substituting an A for a G, can cause a significant
change in the conductance of the molecule. These researchers actually “wired” DNA to identify mutations
and track mutations for cancer research. A number
of researchers have studied genes implemented in
DNA mismatch. Kramer et al (1989) studied gene
PMS1 and its involvement in repairing DNA nucleotide mismatch. Baker et al (2007) postulated that
the formation of DNA-protein cross-links (DPCs)
by chemicals or radiation is often accompanied by
damage responses. Nanotechnology scientists such as
Lee et al (2008) from Ohio University have managed
to uncoil DNA and form them into precise patterns
to use them as wires in biologically based electronics
/ medical devices. The problem with manipulating DNA,
however, is that an accidental nucleotide substitution could
lead to mutations and disease. Since DNA demonstrates
conductivity in its native conformations, it may be plausible to study the electrical circuits emerging out of electron
transport within DNA. The common denominator of such
electrical circuits may delineate a resultant DNA energy
form with a specific pattern and rhythm. Subsequently,
we could develop an electronic device that resonates such
“central control waveform” serving as a DNA “pacemaker”
for damaged DNA.
Electrical Properties of Proteins.
Mc Leoh et al (1987) investigated the effect of electric
current on protein biosynthesis in mammalian fibroblasts.
Protein synthesis was (1) orientation specific (only cells
parallel to the electric field responded); (2) frequency specific -- around .5 Hz and (3) current density specific -around of .3 microamps. Results suggest cell-mediated
changes in tissue repair and remodeling. Other cells such
as ganglion cells respond to 2 microamps/c2 and .5 Hz.
Simoncini & Moody (1991) in the University of Washington showed that the development of electrical properties
in these cells involves RNA and Protein Synthesis. When
transcription (DNA converted to RNA) is blocked the
Ca2+ and outward K+ currents fail to appear. The presence
and significance of electrical energies in the primal components of cellular memory (DNA) and cellular intelligence
(proteins) begs for more research focused on the decoding
and resonance of ionic current waveforms for future implementation in medical treatments.
Development, Tissue Healing & Ionic Currents
A number of research studies appear to place ionic currents in the very essence of living matter. All embryos investigated by Nucciteli’s team (2003) drove Ionic currents
through themselves (100 microamps per square centimeter)
and these currents generated internal electric fields. These
findings are reminiscent of Li’s proposition (2008) that
Embryonic Stem Cells are regulated by ionic currents. In
investigating embryo chickens, Nucciteli et al (2003) found
that the chicks’ internal electric fields were important for
the development of their tail structures. Reducing the
magnitude of the chick’s endogenous electric fields resulted
in abnormal tail development. Nucciteli et al (2002, 2003,
2004) have reported that
mammalian skin wounds
generate endogenous electric fields of 150 millivolts
per millimeter. These endogenous electric fields
are lateral to the wound.
Epidermal wounds exhibit
lateral endogenous electric
fields of 40 millivolts per
millimeter. These specifications of endogenous electric fields suggest that external
electric fields that may promote developmental growth or
wound healing should be limited to magnitudes of less than
SUMMER 2008
IONIC CURRENTS
Biological
4
Dynamics
0.1 volts per millimeter. Endogenous wound electric
fields have been shown to exist naturally at the site of
a lesion since more than 150 years ago when the German physiologist Emil Du-Bois Reymond first identified them. Several experiments have indicated that
when the endogenous electric field is experimentally
removed, the wound healing rate is 25% slower. Nucciteli (2003) reports that nearly every clinical trial using electric fields to stimulate healing in mammalian
wounds has a significant increase in the rate of healing from 13 to 50%. Mukerjee et al (2006) fabricated
a microneedle array and applied it to the measurement of transdermal skin potentials in human subjects. Potential changes were recorded in the vicinity
of superficial wounds, confirming the generation of
a lateral electric field in human skin. The measured
electric field decayed with distance from the wound
edge. Additionally, the electric field was directed
towards the wound, in other words it had a specific
orientation. The measurement of endogenous fields
in skin is a prelude to the study of the therapeutic efficacy of applied electric fields to chronic non-healing
wounds.
Electrons as Anti-oxidant in Wound Healing
Lee et al (2005) used ultra low microcurrent (from
3 milliampere to 400 nano amperes) combined with
low frequencies and an adjustable voltage to attain
constant current, to treat 25 chronic skin ulcers with
the following chronic etiologies: AIDS, Arterial Insufficiency, CerebroVascular
Accident,
Chronic Obstructive
Pulmonary Disease,
Chronic Renal Failure, Congestive Cardiac Failure, Spinal
Cord Injury, Traumatic Brain Injury
and Venous Stasis.
100% of the lesions
treated with nano
current healed in a
maximum time of 7
weeks. Average time
of healing was 48
hours of treatment
over 16 days. Surgical debridement was
unnecessary as the
necrotic tissue appeared to disappear spontaneously.
The lower the frequency the faster the healing. None
of the healed lesions showed any sign of recurrence
after a period ranging from six to eighteen months.
SUMMER 2008 Treating chronic skin ulcers with ultra-low microcurrent
(nano amperes) eliminates the age factor by equalizing the
healing rate at all ages. Lee et al (2005) postulated that healing was the result of nano current acting as an anti-oxidant
by infusing a steady stream of electrons through the cells with
as little resistance as possible. Mitochondria is the principal
source of energy for all cells, but also the primary site of free
radical production as a result of oxidation (loss of electrons).
Free radicals are highly reactive molecules with one unpaired
electron that damage cellular structures such as membranes,
proteins, leading to protein denaturation (image), and cause
nuclear and mitochondrial DNA denaturation (image).
Mictochondrial DNA is far more primitive and hence more
vulnerable to damage than nucleus DNA. Mitochondrial
dysfunction is associated with Parkinson’s Disease, Alzheimer’s Disease, Heart Disease, Cancer and Aging. Antioxidants
have the ability to donate electrons without becoming free
radicals themselves. Nano current offers an ample supply of
electrons that can stabilize a large number of free radicals.
Molecules on Wheels
A few years ago, Yoshida stated that “there are no living organisms on wheels. He then conducted a unique experiment to test Boyler’s theory (Nobel Prize 1997) regarding
the rotation of ATP synthase. Yoshida fixed the only 10nmdiameter hexamer surrounding the stalk of ATP synthase
with fluorescently labeled 1µm-length actin filaments on the
coverslip, and succeeded in visualizing and videotaping the
rotation of ATP synthase. “Everyone was surprised including
myself because the primitive enzyme in every living organism rotated,” Yoshida reported. Until then It was believed
that living organisms did not favor rotation. The discovery
of ATP synthase rotation gave Broiler the Nobel Prize after
20 years of skepticism rooted in a static view of the biological
system that allowed no room for the systematic rhythmical
movement of cooperative enzymes and molecules working
together like senior factory workers during production time.
Rodelez et al (2005) forced ATP synthesis by a nano apparatus that spined the F1 ATPase clockwise. When ATPase
was released by the nano apparatus that spined it clockwise
motion designed to produce ATP), ATPase resumed its
APT hydrolyzing anti-clockwise rotation that breaks down
ATP to ADP plus a phosphate. Therefore ATPase synthesizes ATP when Fo spins it clockwise and on its own, it spins
anti-clockwise to hydrolyze ATP – a little like saying it goes
forward in time to produce ATP (three phosphates) and
then goes backward in time to return ATP at its earlier stage
of existence when it was only ADP (two phosphates). If
cellular life is fueled by a forward time backward time event
then how could we possibly say with certainty that living
and aging is a linear process that can only go one direction,
from birth to death with no energy conservation mechanism
accounting for anti-clockwise reversal? Cellular energy is
spent by breaking ATP down to ADP which is immediately
recycled in the mitochondria to become recomposed into
ATP. This process depends on the driving force of protons
and electrons, i.e. electricity. In fact, all matter is made of
protons and electrons. Unlike matter, however, electricity is
a dynamic whole, a Gestalt that results from the interrela-
❘ 201
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5
Dynamics
202 ❘
tions between protons and electrons. Electricity is
neither protons nor electrons in themselves but the
electrical charge that results from opposites such
as protons and electrons attracting each other. So
how is electricity related to ATP? The answer may
be as simple as saying: “by providing the body with
an abundance of electrons, the movement of which
is used to build a gradient of protons that spin the
ATP synthase producing ATP, the energy necessary
for the survival of the biological organism.” Electrical ranges of 50 microamps significantly increase
ATP. However, ATP synthesis drops down to zero
at ranges above 1.5 milliampere (Cheng 1982; Santos 2004). A meticulous understanding of the effect that different electrical waveforms have on the
biological system is necessary. Two different sets
of electronic specifications may have vastly different
results.
Nuclear Architecture & Spatial Organization
A fundamental aspect of biological systems is their
spatial organization. Taddei et al (2008) and Gasser
et al (2008) have studied the HXK1 gene of budding yeast. They have found that gene expression
is stronger when the gene is attached to the nuclear
envelope (the membrane that surrounds the nucleus)
than when it moves away from the nuclear envelope
(see image below). In other words, cells make use of
the nuclear architecture to code epigenetic information. The DNA sequence alone doesn’t determine everything. The importance of the spatial organization
or nuclear architecture in regulating gene expression
begs for scientific observation that does not merely
focus on the study of atoms and molecules, (the basic components of a Gestalt); but on the interrelations, sequence, orientation and spatial organization
of these atoms and molecules (the dynamic whole
or Gestalt). In development, regeneration and repair,
directional signals are necessary for the proper placement of the components of the organism. Likewise,
pathogens that invade other organisms rely on directional signals to target vulnerable areas. It is widely
understood that chemical gradients are important
directional signals in living systems. Less well recognized are electrical fields, which can also provide
directional information. Endogenous electrical fields
can generate chemical gradients of charged macromolecules against the leveling action of diffusion.
At the site of a lesion in an ion-transporting epithelium, for example, a substantial electrical field is
instantly generated and may extend over many cell
diameters. Spatial organization of directional electric signals is necessary for the proper placement of
biological components. Small, steady electrical fields
can directly guide cell movement and growth and they can
direct cell migration during wound healing. The direction of
ion movement towards or against a site is absolutely crucial.
Zhao et al’s (2006) demonstrated that electric currents can
act as directional cues in cell movement and wound healing. These cues activate signaling pathways similar to those
reported for chemotaxis2. Two specific genes PI(3)Kg and
PTEN were identified as the genes essential for electricalsignal-induced wound healing, demonstrating that PI(3)Kg
and PTEN genes control electrotaxis, i.e. the movement of
cells in response to an electric field.
Ionic Currents and Future Research
The relationship between protons and the Na+/K+ (Sodium
/ Potassium) ATP synthase, electrons and oxidative damage are plain and obvious. Everyone who reads about Na+/
K+ ATP synthase reads about protons. Everyone who reads
about free radicals, reads about how free radicals are unstable
molecules in search of their missing electron. Yet, there is a
conspicuous omission of what protons and electrons make
together by virtue of being attracted to each other, i.e. electrical charge. Scientists have been discussing ion channels
long before Neher’s Nobel Lecture (1991) on the Patch
Clamp cell recording method. The cell membrane is studded with special proteins that let selected ions pass across an
otherwise impenetrable barrier. These ion pathways, called
ion channels, are responsible for a wide variety of functions
such as transmission of electrical signals in nervous systems,
initiation of immune responses and cell division. Cells also
contain ion channels in internal membranes, around mitochondria and nuclei for example. Many clinically used drugs
such as calcium channel blockers and anaesthetics interact
specifically with ion channels. Many major pharmaceutical
companies are showing increasing interest in ion channels
as a new drug target. (Young et al, 2001) Yet, very little research has been invested in decoding endogenous electrical
signals that map biological interactions and their outcomes
to investigate the possibility of a “central control biological
waveform” emerging from the sum total of endogenous electrical signals in synch, in a healthy body. This “central control biological waveform” is a dynamic Gestalt distinguished
from its parts like white light is perceived as distinctly different from all other colors that compose it. Identifying such a
“master physiological waveform” may serve as the blueprint
for a device with a multi sine waveform that can boost, revive
or replace inadequate or erratic endogenous ionic currents
providing the body with a type of a versatile pacemaker designed for a number of biological functions at the molecular
level. Biological signals must be first analyzed in terms of
their amperage, frequency, voltage, spatial organization; then
translated into electronic signals that comply with the biological specifications. Electronic signals will then be intertwined to orchestrate a key “central control waveform” built
on the basis of information attained from observations of
molecular interactions and architecture – a process similar
to that done in Pollock’s lab (1988-2008). Using his expertise on the Pacemaker technology, Pollock (2008) built a
pure analog, multi-sine “smart” waveform that decodes and
2Chemotaxis: movement of cells in response to chemical stimulation.
SUMMER 2008
IONIC CURRENTS
Biological
6
Dynamics
resonates the pattern, rhythm and spatial organization of the nerves’
biological signal during strenuous exercise.
The overall sense of
wellbeing that results
from using Pollock’s
device suggests that
his “central control”
Pure Analog Multi-sine
pure analog waveform
“smart” waveform
may act as a reparative
force, as well as an electronic diplomat to awaken the
activation of biological reparative mechanisms involved in extended longevity.
Conclusion
A meta analysis of current anti-aging research up
to April 2008 was cited from a systemic perspective, envisioning the biological processes in flux with
complexities arising out of the sequence, interactions,
motion and orientation of its elements. Quantum
Physics has shown us that when we are looking at
an atom, we are not looking at a unit, we are looking
at a dynamic whole, a Gestalt formed out of energy
interrelationships. In looking at a protein we are not
looking at a separate entity with a specific function
like a bolt or a screw. We are looking at a Gestalt
of amino acid connections by virtue of their electromagnetic charges. Changes in the sequence of these
amino acids will alter not only the composition of
the protein but its fate and function. Yet none of
these amino acids viewed individually are a protein in
themselves. When the 20 different amino acids that
cells use are linked together, they form over 100,000
proteins by virtue of thousands and thousands of different ways in which they can be combined.
then returns in its entirety as if it never broke. Isn’t this an
example of the CPT theorem involving Charge, represented
by protons and electrons, Parity reflects the space inversion
of the clockwise and anti-clockwise rotation, and Time?
Can the old, the ill, and the injured merely reflect disarranged patterns of molecular elements interrupting biological processes, a concept equivalent to multiple car accidents
in rush hour traffic? A single substitution of an A for a G
in a DNA molecule can cause a significant change in the
conductance of the molecule leading to cancer. Shanklin et al
(2006) reported that a single substitution in the amino acid
sequence of an enzyme changed its function into that of a
theoretical distant ancestor, as if in a single stroke one could
turn the clock 2.5 billion years back. Such evidence gives us
an inkling that aging may be reversible. Opening our minds
to such hypotheses, taking risks in initiating research that
is impossible to complete in a lifetime may indeed help us
unlock biological secrets that are presently beyond our realm
of understanding and belief system.
Proactive Anti-aging Medicine
Diverse research evidence has been integrated to elucidate
the dynamic organization of the biological system and the
need for a multidisciplinary approach to anti-aging. We
rely on research in Medicine and Physiology; Genetic research for information on genes associated with the aging
process; Molecular Biology for a more detailed analysis of
the structure and multi-functions of the cells; Medical research on health, anti-aging and disease; Quantum Physics to delineate interrelationships between ionic particles;
Mathematics to organize data and give us insight of vector theory and dynamic fields; Systems theory to simplify
information processing by grouping and categorization; the
Gestalt principle to identify processes composed by other
underlying sub-processes; Cellular Architecture to identify the detailed design and spatial organization of the biological organism; Electronics and computer programming
to reconstruct and resonate organic functions aiming towards a technology that enhances reparative mechanisms,
extending longevity. No science is irrelevant in grasping
the grand scheme that sustains life. Not only Physiology
and Medicine but all other disciplines are necessary for
advancing to Proactive Anti-aging Health Services.
Is Aging a Linear Inevitable Process?
The arrow of time says that past progresses to future
and that this process is irreversible: we can turn eggs
Xanya Weiss, Ph.D, has a Research
into omelets but not omelets into eggs, and a broken
Doctorate in Neurophysiology from
glass does not go back to what it was before it broke.
City University, London, UK, and
In contrast, the microscopic laws of physics allow for
a Doctorate in Clinical Psy from the
reversibility, for every allowed process there exists a
Gestalt founded New School for
time-reversed process e.g. by exchanging particles for
Social Research, New York, USA.
antiparticles — the CPT Theorem -- I.e. the funShe is affiliated with the European
damental symmetry of physical laws under transforCommunity funded BIC (Business
mations that involve the inversions of (C) charge i.e.
Innovation Center) in the UK-- a
electricity, (P) parity. I.e. space inversion, and time simultaneously. This is exactly what ATPase does when Research Center where most European Universities are conit rotates clockwise to produce ATP and then rotates ducting EU funded research.
anti-clockwise to hydrolyze ATP into ADP and an
© 2008 www.arasysperfector.com
phosphate — very much like a glass that breaks and
SUMMER 2008
❘ 203
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HydroMassage
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W W W. W O R L D H E A LT H . N E T
Flaxseed for Heart-Healthy Nutrition
By John H. Maher, DC, DCCN, FAIIM
The use of flaxseed in food and beverages, functional foods and dietary
supplements has risen dramatically. This
is related to the increasingly recognized
benefits of flax’s rich omega-3 fatty acid,
lignan (powerful phytonutrient phytoestrogens/antioxidants) and fiber content.
A typical flax profile is approximately
40% fat, being mostly omega-3 as alphalinolenic acid (ALA); 28% dietary fiber,
21% protein, 4% mineral ash and 6%
carbohydrates.1 To get an idea of how
omega-3 ALA rich flaxseed is compared
to other ALA-rich foods, the following
should be instructive.
One and a half teaspoons of ground
flaxseed supply 1,000 mg of ALA in 40
calories. One half teaspoon of flaxseed
oil supplies the same 1,000 mg ALA in
20 calories. To get the same 1,000 mg
of ALA, the following amounts of other
sources is needed:
• five walnut halves,
(70 calories);
• 2 teaspoons of canola oil,
(80 calories);
• 1 tablespoon of wheat germ or
soybean oil (120 calories);
• 2 ounces of salmon, herring albacore,
sardine, rainbow trout, or eel (100
calories);
• 9-12 ounces of most other fish, (300
calories or more);
• 5 cups cooked broccoli, (220
calories);
• 10 cups cooked spinach (280 calories);
• ¾ cup soy nuts (285 calories); and
• ¼ cup rice bran oil, (480 calories).2
And all of the above plant sources are
richer in omega 6 than omega 3. None
has flax’s most desirable 3 to 1 omega-3
to omega-6 ratio.3
ALA, EPA, DHA
ALA is converted in the body to
eicosapentaenoic acid (EPA) and, to a
much lesser extent, docosahexaenoic
acid (DHA).4,5 EPA and DHA as such
are found abundantly in fish oil. Both of
these longer-chain omega 3 fatty acids
are known for their salubrious effects on
cardiovascular health.6 However, flaxseed
also has impressive support for its hearthealth-promoting benefits.
ALA Improves Heart Health
Below is a small list of scientific studies
supporting the benefit of a high-ALA diet
derived from plant sources.
• Supplementation with 8 g/day of
ALA resulted in significantly lower
systolic and diastolic blood pressure
levels. There was observed a hypotensive effect of ALA, which may constitute another mechanism accounting in
part for the apparent cardioprotective
effect of this n-3 fatty acid.7
• To compare the effects of ALA to
EPA + DHA on cardiovascular risk
markers in healthy elderly subjects, a
randomized double-blind nutritional intervention study was done on 37 mildly
hypercholesterolemic subjects (14 men
and 23 women ages 60 to 78 years.)
During a run-in period of three weeks,
subjects consumed an omega 6, oleic
acid-rich (LN) diet. The following six
weeks, 10 subjects remained on the control diet, 13 subjects consumed an ALArich diet (6.8 g/day) and 14 subjects
an EPA/DHA-rich diet (1.05 g EPA/
day + 0.55 g DHA/day). The researches
concluded in the European Journal of
Clinical Nutrition that in healthy elderly
subjects, ALA might affect concentrations of LDL cholesterol and apoB more
favorably than EPA/DHA.8
• The Health Professionals Follow-up
Study reported in the British Medical
Journal a 1% increase in ALA as a percent of total calories associated with a
40% risk reduction in nonfatal coronary
heart disease.9
• A 2001 article in the Journal of Nutrition Health and Aging noted that both
Crete and Japan have the greatest life
expectancy among First World countries. They also enjoy the highest levels
of dietary ALA and the lowest intakes
of saturated fat.10
• The Lyon Diet Heart Study included
as participants patients who had survived a myocardial infarction (MI). The
experimental group consumed a typical
Mediterranean-style diet rich in ALA.
The controls enjoyed a diet low in ALA,
typical of the Standard American Diet
208 ❘
SUMMER 2008
Flaxseed for Heart-Healthy Nutrition (SAD). The experimental ALA group
had a 75% reduction in nonfatal myocardial infarctions and a 70% reduction
in death from all causes compared to
the SAD group.11
A number of studies have focused on
the health benefits provided specifically
by flax.
• Women who consumed 50 g of milled
flax a day (1/8 cup) for four weeks
garnered total blood and LDL-cholesterol level reductions of 9% and 18%,
respectively.12
• The Journal of Nutrition reported in
2004 that two ways ALA may protect
the heart are through (1) improvements
in abnormal heart rhythms; and (2) a
reduction of blood platelet stickiness
and resultent.13
• Also in 2004, data from the Nurses
Health Study demonstrated that the
higher the ALA intake, the lower the
plasma concentrations of CRP.14 The
following year, the European Journal
of Clinical Nutrition reported that a
diet high in ALA dramatically decreased CRP in men and women with
high cholesterol levels.15 In 2005, the
American Heart Association presented
studies showing ALA lowers C-reactive
protein (CRP), an ever-more-important
biomarker of inflammation.
• Lowering C-reactive protein may be
as important as reducing LDL cholesterol for heart attacks and stroke
prevention.16 Fifty percent of all strokes
and MI in the United States and
Canada happen to persons with normal
cholesterol findings. Twenty percent of
all major cardiovascular events happen
to folks with no major risk factors!17
• Even more recently, the American
Journal of Physiology Heart and Physiology Circulation shared that in rabbits
with hypercholesterolemia, dietary
flaxseed inhibited vascular contraction
and atherosclerosis formation.18
• Lanzmann and Petithory, in a review
of studies focusing on flax and ALA,
concluded that this ALA rich essential
fatty acid (EFA) source may reduce
ventricular fibrillation.19
• The above research is leading to a
consensus that flaxseed has very benefiSUMMER 2008 continued from page 208
cial effects in the prevention of cardiovascular disease.20,21 It is apparent even
from this brief introductory review
that the cardioprotective benefits of a
flaxseed-rich diet come from numerous
salubrious mechanisms. This research
suggests that these many benefits occur
despite differences in study populations,
length of follow-up, outcomes, and
methods of statistical analysis.
ALA RDA?
At the present time, there is no Recommended Dietary Allowance (RDA) for
EFAs in the U.S. However, the National
Academy of Sciences’ Institute of Medicine (IOM) recommends 1.6 g/day of
ALA for men and 1.1 g/day for women.22
Excellent Source of
Dietary Fiber
Numerous health benefits are derived
from consuming ALA in flax. Not to be
overlooked is flaxseed’s dietary fiber content
(28%), which generates additional health
benefits. The American Dietetic Association has cited fiber’s “significant impact” on
obesity, cardiovascular disease and type 2
diabetes prevention and management.23
Flax has a ratio of soluble to insoluble fiber that can vary in a ratio of between one
part soluble to four parts insoluble to four
parts to six parts, respectively.24 Insoluble
dietary fiber supports healthy elimination and colon health, and may even have
protective effects against colon cancer.25
The soluble dietary fiber fraction of flax is
found primarily as mucilage gums, which
have been shown to play a role in lowering
serum cholesterol levels.26 u
REFERENCES
1. www.flaxcouncil.ca/english/index.
php?p=n3&mp=newsline#Good.
2. Ibid.
3. www.annecollins.com/dietary-fat/omega-3-efa-6-chart.
htm.
4. Harper CR, Edwards MJ, DeFilipis, et al. Flaxseed oil
increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. J Nutr, 2006;136:83.
5. Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and
docosahexaenoic acids in young women. Brit J Nutr,
2002;88:411-420.
6. www.flaxcouncil.ca/english/pdf/FFtsheet_Fish_Flax_
R2.pdf.
7. Paschos GK, Magkos F, Panagiotakos DB, Votteas
V, and Zampelas A. Dietary supplementation with
flaxseed oil lowers blood pressure in dyslipidaemic
patients. European Journal of Clinical Nutrition,
2007;61:1201-1206.
8. Goyens PLL and Mensink RP. Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular
risk markers in healthy elderly subjects. European
Journal of Clinical Nutrition, 2006;60:978-984.
9. Ascherio A, Rimm EB, Giovannucci EL, et al. Dietary
fat and risk of coronary heart disease in men: cohort
follow-up study in the United States. Br Med J,
1996;313:84-90.
10. Renaud S, de Lorgeril M, Delaye J, et al. Cretan
Mediterranean diet for prevention of coronary heart
disease. Am J Clin Nutr, 1995;61(Suppl):1360S-7S.
11. www.americanheart.org/presenter.
jhtml?identifier=4655.
12. Cunnane SC, et al. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr,
1995;61(1):62-68.
13. Lopez-Garcia, E, Schulze, MB, Manson, JE, et al.
Consumption of n3 fatty acids is related to plasma
biomarkers of inflammation and endothelial activation
in women. J Nutr, 2004;134:1806-1811.
14. Ibid.
15. Bemelmans WJE, Lefrandt JD, Feskens EJM, et al.
Increased alpha-linolenic acid intake lowers C-reactive
protein, but has no effect on markers of atherosclerosis. Eur J Clin Nutr, 2004;58:1083-89.
16. American Heart Association. “Inflammation, Heart
Disease and Stroke: The Role of C Reactive Protein.”
www.americanheart.org/presenter. Oct. 26, 2005.
17. Simopoulos AP. Essential fatty acids in health and chronic disease. Am J Clin Nutr,
1999;70(Suppl):560S-569S.
18. Dupasquier CMC, et al, Effects of dietary flaxseed
on vascular contractile function and atherosclerosis
during prolonged hypercholesterolemia in rabbits. Am
J Physiol Heart Circ Physiol, 2006;291:H2987-H2996.
19. Lanzmann-Petithory D. Alpha-linolenic acid
and cardiovascular diseases. J Nutr Health Aging,
2001;5(3):179-183.
20. Renaud SC, Lanzmann-Petithory D. The beneficial
effect of a-linolenic acid in coronary artery disease is not questionable (letter). Am J Clin Nutr,
2002;76:903-904.
21. Vos E, Cunnane SC. a-linolenic acid, linoleic acid,
coronary artery disease, and overall mortality (letter).
Am J Clin Nutr, 2003;77:521-522.
22. Anon. Dietary Reference Intakes for Energy, Carbohydrates, Fiber, Fat, Protein and Amino Acids (Macronutrients). 2002. National Academy of Sciences, Institute of Medicine, Health and Human Service’s Office
of Disease Prevention and Health Promotion (U.S.).
23. American Dietetic Association. Health implications
of dietary fiber – position of American Dietetic Association. J Am Diet Assoc, 1997:971157-1159.
24. Hadley M, Lacher C, Mitchell-Fetch J. Fiber in Flaxseed. Proc Flax Inst, 1992;54:79-83.
25. Ibid.
26. Ibid.
◗ Dr. Maher is co-founder and vice president of
education and research at BioPharma Scientific
(www.biopharmasci.com). He is a past postgraduate faculty member of the NYCC Academy of
Anti-Aging Medicine, a diplomate of the College
of Clinical Nutrition, and a fellow of the American
Academy of Integrative Medicine. Dr. Maher
maintained an active alternative health care
practice for 25 years. He can be contacted at
[email protected] for more information.
❘ 209
BUYERS Guide
TavTech
56 Haatzmaut St. P.O.B. 1167
Yehud, 56000
Israel
BioPharma
Scientific
9010 Kenamar Dr Suite 101
San Diego, CA 92121
USA
NanoGreens10 and NanoProPRP
have been shown by independent
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www.nanogreens.com
ALTERNATIVE THERAPIES
AMARC Enterprises
ALTERNATIVE THERAPIES
+972-3-5360515
www. tav-tech.com
1339 Broadway
San Diego, CA 92021
USA
American
BioSciences, Inc.
560 Bradley Pkwy. #4
Blauvelt, NY 10913
USA
866-765-9682
www.polymva.com
Avé ™Fermented Wheat Germ
Extract Supports metabolic cell
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flexsolve 24/7Tm Formulation of
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888-884-7770
www.americanbiosciences.com
Clear Mind Center
2101 Business Center Drive #100 949-222-1020
Irvine, CA 92612
www.clearmindcenter.com
USA
3915 NE 38th St.
Vancouver, WA 98661
USA
360-695-7500
Magnetico
5421- 11th St. NE, #109
Calgary, Alberta T2E 6M4
CANADA
403-730-0883
www.magneticosleep.com
Novus Optimum Lab
P.O. Box 640588
San Francisco, CA 94164
USA
Arasys Perfector/
Ion Magnum LLC
7773 Waikapu Loop
Honolulu, HI 96825
USA
808-395-0656 or 866-25-YOUNG
www.ionmangum.net
Aquavida
PO Box 7915
Ocean Isle, NC 28469
USA
210 ❘
910-443-7725
www.aquavidausa.com
Oxy Health, LLC
10719 Norwalk Blvd.
Santa Fe Springs, CA 90670
USA
415-986-8991, 888-499-9100
www.novusoptimum.com
OxyHealth has changed how the
medical industry looks at hyperbaric
medicine and paved the way
for the modern hyperbaric practice.
With over 6,500 portable and steel
chambers in service today,
OxyHealth has refined “industry
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OxyHealth makes hyperbarics
come to you.
562-906-8888
www.oxyhealth.com
The BioMat Company
3708 NE 109th Ave., Apt. BB10
Vancouver, WA 98682
USA
503-880-0475
libby.thebiomatcompany.net
SUMMER 2008
BUYERS Guide
COMPOUNDING PHARMACIES
Abrams Royal
Pharmacy
8220 Abrams Road
Dallas, TX 75231
USA
Abrams Royal Pharmacy uses the
latest in precision equipment, sterile
compounding facilities, pharmaceutical grade chemicals, and
quality control to help find solutions
to your patient’s health care challenges. We compound medications
free of dyes, fillers, fragrances, and
common allergens, and we specialize in locating hard to find products,
chemicals, forms, and formulas.
COMPUTER / EMR
E-TelMed
5489 Wiles Rd., Suite 303
Coconut Creek, FL 33073
USA
MD-Ware Software
1788 Drew Rd., Suite A
Mississauga, ON L5S 1L7
CANADA
954-984-2929
www.etelmed.com
800-798-6199
www.mdware.com
COMPOUNDING PHARMACIES /ALTERNATIVE THERAPIES
/ COMPUTER / EMR / COSMECEUTICALS
214-349-8000
www.abramsroyalpharmacy.com
Prime Clinical System, Inc
3675 E. Huntington Drive #4
Pasadena, CA 91107
USA
ApothéCure, Inc.
4001 McEwen Road, Suite 100
Dallas, TX 75244
USA
800-969-6601
www.apothecure.com
COSMECEUTICALS
College Pharmacy
3505 Austin Bluffs Pkwy., Suite 101 719-262-0022
Colorado, Springs, CO 80918
www.collegepharmacy.com
USA
MedQuest Pharmacy
669 W. 900 North
North Salt Lake, UT 84054
USA
Prescription Center
915 Hay Street
Fayetteville, NC 28305
USA
626-449-1705
www.primeclinical.com
888-222-2956
www.mqrx.com
Aminocare Products, L.P.
9432 Old Katy Rd., Suite 200
Houston, TX 77055
USA
International
Wellness Clinic
240 Conestoga Road,
Wayne, PA 19087
USA
800-682-4664
www.rxfixer.com
800-856-8006
www.aminocare.com
Vinoy Oxygen Anti- Aging Facial
Cream and Serum combine
Oxygen with over 20 of the finest
European plant extracts and
nutrients for skin rejuvenation. These
exquisite world-patented products
from Germany improve wrinkles and
sun damage and increase elasticity,
hydration, collagen and elastin.
Available in the US only through the
International Wellness Clinic.
610-971-9355
Women’s
International
Pharmacy
2 Marsh Court
Madison, WI 53718
USA
For over 22 years Women’s International Pharmacy has specialized in
custom compounded bioidentical
hormone prescriptions for men and
women. Women’s International Pharmacy is a trusted source for practitioners and their patients. Our pharmacy provides quality compounded
prescriptions, excellent customer
service, consulting services, and
upon request, educational information on hormone therapies.
800-279-5708
www.womensinternational.com
212 ❘
Iredale Mineral Cosmetics
28 Church St.
Great Barrington, MA 01230
USA
800-762-1132
www.janeiredale.com
Jan Marini Skin Research
6951 Via del Oro
San Jose, CA 95119
USA
800-347-2223
www.janmarini.com
SUMMER 2008
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Fucose Complexes, Fucoxanthin,
Fucoid and Fat Storage
By Stephen Holt, MD, LLD (Hon.), ChB., PhD, ND, FRCP (C) MRCP (U.K.), FACP, FACG, FACN, FACAM, OSJ, Distinguished Professor of Medicine, Chairman, New York Department of Integrative Medicine at NYCPM, President, World Organization of
Natural Medical Practitioners
Introduction
The versatile medicinal benefits of
certain types of seaweed and their derivatives1,2 have been highlighted recently in
the weight control arena.3-7 While the
value of seaweed-derived fucoxanthin has
attracted much attention as a thermogenic
agent, seaweed contains several other functional components that could benefit an
individual with excessive body weight.7-9
The objective of this article is to sort
science from speculation on the value of
certain types of seaweed and their extracts
as natural medicines, with special reference
to their use in weight control.
BLUE-GREEN
GREEN
Spirulina
Chlorella
Ulva spp.
Monostroma spp.
Enteromorpha spp.
RED
Porphyra spp.
Chondrus spp.
Palmaria spp.
BROWN
Laminaria spp.
Fucus spp.
Undaria spp.
Table 1. Examples of the genus of algae (seaweeds) classified by color.
Seaweed: A Brief Overview
Seaweed has been used in the food
chain from time immemorial, and there
is a colorful history of its application for
medicinal purposes.9 Seaweed belongs to
a large group of plant life called algae.9
There are two major categories of algae:
unicellular and macroalgae.1,2,9 Unicellular algae include spirulina, chlorella and
plankton. These single-cell algae have
been widely applied in dietary supplements because of their content of vital
nutrients. In contrast, macroalgae are
much bigger organisms and are commonly
known as seaweed or “kelp.”9 These sea
plants have some physiological resemblances to plants on land, and they can
range in size from centimeters to up to
200 meters or more in width or length.9
Seaweeds come in shades of yellow,
brown, blue, green and red, and there are
more than 3,000 species of algae in the
oceans worldwide (Table 1).9
Understanding the “botanical” classification of marine algae is a monumental
task.1,2,9 There are essentially four major
groups of algae that can be classified
by color, namely green (Chlorophyta),
brown/yellow (Phaeophyta), red (Rhodophyta) and blue green (Cyanophyta)
(Table 1).9 The color of algae is deter-
214 ❘
mined by mixtures of pigments that play
a variable role in photosynthesis. These
pigments include chlorophylls, carotenoids and phycobillins.1,2,9
Pigments in seaweeds have important nutraceutical properties including
antioxidant and biological responsemodifying qualities.9 Most relevant to the
present discussions are the carotenoids
found in seaweeds.9-13 These red, orange
or yellow compounds are composed of
short, carbon chain-connected 6-carbon
rings that are hydrophobic (e.g., combinations of mevalonic acid and lycopene
or related compounds). Carotenoids cannot transmit sunlight into photosynthetic
pathways, but they function as accessory
pigments. A prominent accessory or
“helper” pigment is fucoxanthin, which is
responsible for the “brownish” appearance
of kelp.9
Seaweed has been used in several traditional medical systems for many medical
purposes including: nutritional support,
cancer therapy, immune stimulation, body
detoxification, weight control, treatment of viral disease, etc.9 The ability of
many types of seaweed to be adjunctive
to weight control has been known for
many years.11-13 Recent interests involve
the ability of antioxidant compounds in
seaweed, specifically fucoxanthin,3, 11-13 to
promote weight loss.9,11-13 While fucoxanthin has some support for its role as
an enhancer of body metabolism (thermogenic effect), with direct effect on fat
stores,11-13 other components of seaweed
may be of benefit in weight control.7
Many types of seaweed are excellent
sources of dietary iodine, which is an essential element for normal function of the
thyroid gland.5 Deficiencies in the function of the thyroid gland may promote
weight gain, and optimal thyroid function
supports lean body mass. Some seaweeds
contain a variety of trace minerals and
vitamins, which provide general nutritional support for individuals who may
be engaged in calorie-restricted diets.9
The presence of certain poorly absorbed
polysaccharides (or types of “fiber”) in
seaweed may assist in providing “bulk”
in the diet.9 This bulking effect enhances
a sensation of fullness in the stomach
or regular bowel habits. Some of the
complex sugars in seaweed are referred to
as fucoids (glucans), which may stimulate immune function.9 Overall, there
is a large amount of scientific literature
SUMMER 2008
Fucose Complexes, Fucoxanthin, Fucoid and Fat Storage continued from page 214
on the use of seaweeds as health food,
soil fertilizers and sources of medicinal
compounds.9
Seaweed in “Natural Medicine”
Several types of seaweed are used
topically in facial treatments, body wraps
and baths, with claims of improvements
in blood circulation, detoxification,
treatment of acne and rosacea and skin
moisturizing, purification, exfoliation or
rejuvenating effects.10 The use of marine
algae in this manner constitutes one aspect of thalassotherapy (Greek: thalassa =
ocean and therapeion = treat), a discipline
based on the belief that “The Sea washes
away all of the ills of mankind.” (Euripides, 480 B.C.)
Many medical or “destination” spas are
using topical seaweed body therapies to
promote skin beauty and health. Seaweed
body treatments are believed to provide
surface minerals that can diffuse into the
skin; and they provide pleasurable and
relaxing experiences when applied in
the correct context. Cosmetic therapists
believe marine algae can enhance skin
circulation, increase local metabolism in
the skin and supporting structures, flush
out toxins and assist in improving skin tone
and smoothness, perhaps by inducing a
mild dermabrasion.10
Certain seaweed applications are believed to be moisturizing and toning for
the skin.10 Specific applications of seaweed
body treatments include attempts to
detoxify the body, treat cellulite, enhance
lymphatic drainage, clear limb swelling
(edema) and even provide rejuvenating
qualities.10 Seaweed “scrubs” are excellent
for skin exfoliation. The evidence base
for these beneficial effects of the topical
application of seaweed remains arguable in
the medical literature.10
Seaweed-Based Nutraceuticals
In addition to the extensive topical use
of seaweed, many types of macroalgae
(kelp or seaweed) are treasured as dietary
inclusions, dietary supplements or sources
of pharmaceuticals.9 Several textbooks and
Internet resources give extensive botanical
profiles of different types of seaweed, with
discussions of their nutritional or potential
medicinal value.9 Examples of particularly
valuable types of seaweed used in oral
SUMMER 2008 supplements include Irish moss (Chondrus
crispus), Fucose or Fucus vesiculosis (Bladderwrack), species of Laminaria, (especially
Laminaria japonica), Sargassum muticum
(Hondawara, Japan and Limu-Lala, Hawaii) and Undaria pinnatifida (Wakame).9
Chondrus crispus, or Irish moss, is an
important source of mixed amino acids,
magnesium and sulfur.9 There is some
evidence that oral intake of Irish moss can
reduce blood cholesterol levels, and it may
have antiviral properties.9 Other proposed
properties of Irish moss include neutralization of gastric acid secretion and possible
exertion of a protective effect on the lining
of the stomach and upper intestines.9 The
sulfur-containing mucopolysaccharides in
Irish moss form a gel when mixed with
water and they are able to retain water up
to 20 times their own weight.9 These gels, in
sufficient dosages, may cause a sensation of
stomach fullness, which is part of the simple,
but valuable “feel-full, weight-loss trick.”
Fucus (Fucose) vesiculosis is a brownish
green seaweed which is in common use in
medicines.9 It is rich in minerals, trace elements, iodine and vitamin C. It has found
application as a dietary source of iodine
and a promoter of immune function.9
Fucoxanthins are abundant in Fucose or
Fucus types of seaweed.4 Independent
laboratory studies suggest this antioxidant
can exert significant thermogenic effects
and assist directly in weight loss.7,11-13
These effects have been noted to be additive with exercise.7
Several species of Laminaria are prized
types of medicinal seaweed that have
been used often in traditional Japanese
medicine and by alternative physicians
in Europe.9 Laminaria seaweeds are a
popular dietary inclusion in Japan and
Korea. These species are rich in iodine,
trace elements, polysaccharides (fucoidan)
and antioxidants with the structure of
fucoxanthin.9
Sargassum species have been used as
stimulants for plant growth in liquid plant
foods and as a traditional Chinese remedy
to deal with excessive mucus production in the body.9 Sargassum muticum
originates most often from Japan and
can grow to a length of several meters.9
This seaweed contains fucoidans and
fucoxanthin-like antioxidants. It serves as
an important source of alginates, which
have widespread use in the pharmaceuti-
cal industry.9
Undaria pinnatifida (Wakame) is a large
brown algae and it is related to the Laminaria types of seaweed.9 In common with
other types of brown algae, it contains
trace elements and antioxidants including fucoxanthin. Undaria species are rich
sources of minerals and trace elements
and they contain “glucans” (fucoid-like
molecules) that may stimulate immunity.9
This group of seaweeds is rich in calcium,
niacin and vitamin C.9
Fucoxanthins
Fucoxanthins “crop up” in the scientific literature in several contexts.9 These
compounds are strong antioxidants,
related to well-known nutraceuticals such
as canthaxanthins, astaxanthins, lycopene,
violaxanthin and neoxanthin.9 The potent
and versatile antioxidant actions of carotenoids are implicated in cancer protection, immune function and anti-aging.9
The anti-aging benefits of seaweed have
been “touted” for years.9
Japanese researchers have shown that
the fucoxanthin components of Undaria (Wakame) may cause up to a 10%
weight loss in experimental animals by
direct effects on shrinking abdominal fat
stores.11-13 Fucoxanthin appears to stimulate proteins (Uncoupling protein-1) that
cause the oxidation of fat and its conversion to energy or heat (thermogenesis).13
Uncoupling protein-1 (UCP-1) appears to
be present in white adipose tissue (belly
fat) and acts on mitochondria in a direct
manner that promotes the oxidation of
free fatty acids, thereby reducing fat tissue
stores.13 The preponderance of white fat
in abdominal fat stores leads to the inference that this upregulating activity
of UCP-1 may be valuable in reducing the
size of a “pot belly.”11-13 Pot bellies are a
hallmark physical sign of insulin resistance
and Syndrome X.
Uncoupling protein-1 is expressed in
brown adipose tissue and plays a major
role in whole-body energy expenditure.
Dysfunction of this regulatory mechanism
promotes obesity. Fucoxanthin exerts its
effects through protein gene expression
in UCP-1 in white adipose tissue, but not
brown adipose tissue (Table 2). Animal experiments show that feeding concentrates
continued on page 216
❘ 215
fucose complexes, fucoxaNThIN, fucoID aND faT sTorage
continued from page 215
FUCOXANTHIN
(SEAWEED)
FUCOXANTHINOL
(SYSTEMIC EFFECTS)
Antioxidant
Actions
Anti-inflammatory
Effects?
Increase
DHA Synthesis
in Liver
Antiobesity Effects through
UCP-1 Upregulation.
Decrease in TNF Alpha in
White Adipose Tissue
Antidiabetic or
Glucose Regula
ting Effects on
Muscle
Table 2. Fucoxanthin is absorbed and converted into fucoxanthinol, which is further metabolized to amarouciaxanthin A and fucoxanthinol.
The end results are antioxidant effects, increased synthesis of DHA in the liver, UCP-1 upregulation in white adipose tissue and glucose-regulating effects in muscle tissue. These combined metabolic effects of fucoxanthin have implications for the management of Syndrome X, and
it appears that anti-inflammatory actions are present, as a predictable consequence of powerful antioxidant effects that have value in “obesitis”
(see text).
of fucoxanthin results in significant weight
reduction in rodents.11-13
When rodents are fed fucoxanthin,
the expression of messenger RNA that
controls UCP-1 was found to be amplified
in amount in white adipose tissue, but
much lower expression of this mRNA was
found in mice who did not receive fucoxanthin.11-13 Fucoxanthin has been found
to reduce blood glucose in animals with
diabetes and in normal mice that are fed
high-fat diets (Table 2). It appears that
fucoxanthin is capable of upregulating
glucose transporter 4 mRNA expression
of L-6 myotubes,11-13 which are responsible for glucose transport in adult muscle
tissue (Table 2). An interesting additional
metabolic benefit of fucoxanthin administration in rodents is the promotion of the
synthesis of docosahexanoic acid (DHA)
in the liver.11-13 The versatile effects of
fucoxanthin on intermediary metabolism
make this carotenoid of great potential
value in the prevention or management of
metabolic syndrome X (Table 2).
The animal experiments with fucoxanthin stimulated researchers to recommend
216 ❘
human clinical trials with fucoxanthin.
Studies in Russia and the U.S. (not fully
reported in the literature), seem to show
notable thermogenic effects of seaweed
antioxidants (fucoxanthin) in humans.14
In placebo-controlled trials, a supplement
containing a 5% fucoxanthin concentrate
(daily dosage: 10 mg), combined with
calorie restriction to 1,800 calories per
day, resulted in an average of 14.5 lbs lost
over a 16-week period. In the placebo
group in this study, individuals lost an
average of 3 lbs in body weight (almost a
fivefold difference).14
In a second clinical experience using the
same supplement formulation, increases
in measurements of metabolic rate were
recorded, without evidence of significant
central nervous system stimulation (average 18% increase in metabolic rate).14 In
open-label observations of a different formula containing fucoxanthin (10% extract)
enhanced with green tea and chromium,
similar weight-loss results were obtained.15
These weight-loss outcomes15 were similar
to those experienced with the previously
mentioned formulation.14
weIghT coNTrol
While one can accept the beneficial
effects of seaweed ingredients on body
metabolism in the overweight individual,
the thermogenic effects of fucoxanthin11-14
are best complemented by other natural substances that can provide valuable
metabolic enhancement.15 Thermogenesis
induced by fucoxanthin can be complemented by metabolic promoters such as
chromium, green tea polyphenols, chlorogenic acid and hydroxycitrate (Garcinia
cambogia).16,17 The limitation of the use of
single dietary supplements for weight control has become increasingly apparent in
recent times, especially given the complex
pathophysiology of obesity.17,18
Chromium has several advantages
for weight control supplements, largely
because of its insulin sensitizing effects
and ability to promote healthy blood
cholesterol.16-18 Green tea polyphenols
exert anti-inflammatory actions and alter
glucose metabolism in a favorable
manner.16-19 In a similar manner,
SUMMER 2008
Fucose Complexes, Fucoxanthin, Fucoid and Fat Storage continued from page 216
chlorogenic acid and other “coffee polyphenols” may favorably alter lipid and
sugar metabolism and afford protection
against the development of type II diabetes mellitus.16-18 Hydroxycitric acid (Garcinia cambogia) may inhibit fat storage by
promoting sugar storage as glycogen and
may suppress appetite, thereby decreasing body weight.17 This supplement has
enjoyed great individual popularity for
many years, but its stand-alone use may
be limited in benefits.
The use of other metabolic enhancers
combined with fucoxanthin has implications for the management of metabolic
syndrome X.11-13 This disorder affects up to
70 million Americans with its variable constellation of overweight status, abnormal
blood cholesterol and/or triglycerides and
hypertension, linked by resistance to the
hormone insulin.16,18,20 The amplification of
the actions of fucoxanthin-containing seaweeds is a synergistic approach to dietary
supplement formulation with more potent
and versatile effects on weight control.21
This modern nutraceutical technology
introduces the concept of a clinical fucose
or fucoxanthin complex formula.
There is no “perfect” or ideal weight
and certainly there is no “perfect diet.”
Weight control is a function of behavior
modification, calorie-controlled diet, exercise and adjunctive care, along with the
judicious use of dietary supplements (or
drugs). Diet alone cannot be relied upon
for sustained weight control and there is
not a dietary approach described in the
history of medicine that ensures longterm weight control.16,17 The “low carb”
dietary approach (popularized by Atkins
and copied by others) is effective in the
short term and I recommend it for its
provision of early weight loss. This initial
weight loss serves as a positive stimulus
for compliance with complex regimens
that are required for sustained weight
balance.17-20
It is clear that the restriction of simple
sugars in the diet is quite safe and it
makes eminent sense for use in mature
individuals who often have insulin resistance as part of the complex of syndrome
X.18,20 However, it must be recognized
that carbohydrate restriction alone has
not been shown to overcome insulin resistance in a consistent manner.17,18,21 This
SUMMER 2008 is a principal reason why an Atkins-like
diet is doomed to failure in the intermediate- to long-term control of body weight. It
is about time dietary fads were avoided in
the professional management of obesity.17
Managing obesity-related disease and the
litany of disorders associated with metabolic syndrome X (Syndrome X, Y and
Z…) are mandatory interventions.16, 18 I fail
to understand why both conventional and
alternative medicine have failed to recognize the global importance of managing
Syndrome X! While 70 million people in
the U.S. have syndrome X, this diagnosis is
missing from many patient charts.17,20
The role of body cleansing or detoxification seems to have emerged in clinical
practice with the increasing recognition of
the role of body toxicity in weight gain.22
Obesity (obesitis) and syndrome X are
associated with a “pro-inflammatory body
status” (obesitis).16 This makes eicosapentanoic acid (EPA in enteric-coated fish
oil supplements) an important adjunctive
weight loss supplements.18,20 EPA is both
anti-inflammatory and sensitizes the action
of insulin by effects on PPAR receptor complexes.18 Seaweeds may contain variable
amounts of marine omega-3 fatty acids.9 An
interesting amplification of the weight-loss
effects of fucose complexes may occur with
the use of nonstimulant appetite-suppressant supplements, such as Hoodia gordonii
or Caralluma fimbriata.23, 24 Of course,
combating overweight status, metabolic
syndrome X and prediabetes are pivotal in
the prevention of type II diabetes.16,18
Conclusion
Overweight individuals and their
caregivers have become desperate when
fat storage in the body is recalcitrant. This
circumstance precipitates a willingness to
look for “easy ways out” and “quick fixes.”
Desperate individuals may tend to accept
“hyperbolic claims” of the effects of drugs
or supplements. There is no quick fix for
the nation’s obesity. While diets are not
“stand-alone” interventions for weight
control, nor are drugs or dietary supplements, the examination of groups of individuals who have controlled their weight
over extended periods of time shows that
such individuals have taken a multipronged approach to weight control.17,18
Weight management is a holistic medical
venture.16,25 u
REFERENCES
1. Van Den Hoek C, Mann DG, Jahn HM. Algae: An
Introduction to Phycology. Cambridge University, Press:
Cambridge, U.K., 1995.
2. Newton Lily. A Handbook of the British Seaweeds. British
Museum, London, U.K., 1931.
3. Jimenez-Escrig A, Jimenez-Jimenez I, Pudilo R, SauraCalixto F. Antioxidant activity of fresh and processed
edible seaweed. Journal of the Science of Food and Agriculture, 2001;81(5):530-534.
4. Yan XJ, Chuda Y, Suzuki M, Nagata T. Fucoxanthin as
the major antioxidant in Hijikia fusiformis, a common
edible seaweed. Bioscience, Biotechnology and Biochemistry, 1999;63(3):605-607.
5. Lee SM, Lewis J, Buss DH, Holcombe GD, Lawrence
PR. Iodine in British foods and diets, British Journal of
Nutrition, 1994;435-446.
6. Moro CO, Basile G. Obesity and medicinal plants. Fitoterapia, 2000;71: S73-S82
7. Holt S. Detoxify your way to a healthier, leaner you.
Doctors Prescription for Healthy Living, 2008;12(2):27.
8. Thomas DN. Seaweeds. The Natural History Museum:
London, U.K., 2002.
9. Web listings and Internet resources provide abundant
information on algae: www.museumoflondon.org,
www.algaebase.org, www.seaweed.ie, www.wikipedia.
org, www.surialink.com, www.fao.org.
10. Roeck-Holtzhauer Yde. Uses of Seaweeds in Cosmetics. In: Guiry MD, Blunden G. Seaweed Resources in
Europe: Uses and Potential. John Wiley & Sons, 1991.
11. Miyashita K. Anti-Obesity by Marine Lipids. Obesity
Epidemiology, Pathophysiology and Prevention; Bagchi
D, Preuss HG, Eds. CRC Taylor & Francis, New York,
2007: 463-475.
12. Maeda H, Hosokawa M, Sashima T, Takahashi N, Kawada T, Miyashita K. Fucoxanthin and its metabolite,
fucoxanthinol, suppress adipocyte differentiation in
3T3-l1 cells. Int J Mole Med, 2006;18:147-152.
13. Maeda H, Hosokawa M, Sashima T, Funayama K,
Miyashita K. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1
expression in white adipose tissues, Biochem Biophys
Res Comm, 2005;332:392-397.
14. LipoxanThin,™ and Grantoil.™ www.specialtynutrition.com.
15. Data on file, Natural Clinician LLC, 2008.
16. Holt S. “Metabolic Syndrome: Syndrome X, Y, Z…?”
Townsend Letter, 2007;286: 91-103.
17. Holt S. Enhancing Low Carb Diets. Wellness Publishing
Inc., Little Falls, NJ, 2004.
18. Holt S. Combat Syndrome X,Y,Z. Wellness Publishing
Inc., Little Falls, NJ, 2002.
19. Holt S. The Supreme Properties of Hoodia Gordonii.
Wellness Publishing Inc., Little Falls, NJ, 2005.
20. Holt S, Wright JV, Taylor TV, Holt FGS. Nutritional
Factors for Syndrome X. Wellness Publishing Inc., Little
Falls, NJ, 2003.
21. Holt S. A Certification Program for Dietary Supplement
Counselors. Wellness Publishing Inc., Little Falls, NJ,
2008.
22. Baille-Hamilton P. The Detox Diet. Michael Joseph, an
Imprint of Penguin Books, London, U.K., 2002.
23. Holt S, Taylor TV. “Hoodia Gordonii: Part 1: An Overview of Biological and Botanical Characteristics.” Townsend Letter, 2006;280:104-113.
24. Holt S, Taylor TV. “Hoodia Gordonii: Part 2: Separating Science From Speculation.” Townsend Letter,
2006;281:99-104.
25. Crister G. Fat Land. Allen Lane, an Imprint of Penguin
Books, London, U.K., 2003.
❘ 217
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BUYERS Guide
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220 ❘
INSURANCE / FINANCE /
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YOUR
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Bio-Identical
Bio-IdenticalHRT
HRTCompounding
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√√ Growth
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√√ Testsoterone
Testsoterone
√√ Progesterone
Progesterone
√√ Estrogen
Estrogen
√√ DHEA
DHEA
√√ Pregnenolone
Pregnenolone
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Free:888.733.0300
888.733.0300
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BUYERS Guide
MED SPA / EQUIPMENT
Body Logic MD
1499 W. Palmetto Park
Rd., #405
USA
A Practice. The Solution. Your
Future. BodyLogicMD is the nation’s
largest network of highly trained
physician-owned practices specializing in bioidentical hormones
integrated with fitness and nutrition.
With 20 offices nationally and rapidly expanding, we offer you a quick
and successful approach to grow
your practice. Find out about our
Risk Free Guarantee.
888-625-8705
www.bodylogicmd.com
ACIGI Relaxation/Fujiiryoki
4399 Ingot St.
Fremont, CA 94538
USA
Arasys Perfector/
Ion Magnum LLC
7773 Waikapu Loop
Honolulu, HI 96825
USA
LocateADoc.com / Mojo Interactive
1060 Woodcock Rd.
Orlando, FL 32803
USA
1514 Kanawha Blvd East
Charleston, WV 25311
USA
Smile Reminder
210 N. 1200 E Suite 150
Lehi, UT 84043
USA
304-720-8820
www.optimalhealthi.com
866-605-6867
www.smilereminder.com
Beautiful Image LLC
PO Box 771328
Ocala, FL 34477
USA
Canfield Imaging
Systems
253 Passaic Avenue
Fairfield, NJ 07004
USA
TodayMD
10825 NW 33rd Street
Doral, FL 33172
USA
808-395-0656 or 866-25-YOUNG
www.ionmangum.net
877-665-6798
www.LocateADoc.com
Optimal Health Institutes
510-651-9088
www.fujichair.com
305-629-3831
www.todaymdmarketing.com
239-216-1123
352-804-6751
The Reveal Imager from Canfield
Imaging Systems is designed to take
high quality facial photographs in
almost any environment. This new
system captures images of surface
and sub-surface skin features and
will photograph front, left, and right
views. It is ideal for spas, medical spas and traditional medical
practices.
800-815-4330
www.canfieldsci.com
www.ZoomDazzle.com
2000 Banks Rd, Suite 214
Margate, FL 33063
USA
www.ZoomDazzle.com will give
you the most advanced, proven
medical marketing systems,
strategies, tactics & tools for you to
quickly and easily integrate and
automate your online and offline
marketing to generate YOU the
most predictable and continuous
flow of qualified prospects, patients
& referrals so YOU can future-proof
your practice, dominate your
market and continue to do what
you do good.
800-399-9781
www.ZoomDazzle.com
HydroMassage
15395 Roosevelt Blvd
Clearwater, FL 33760
USA
Lumenis, Inc.
5302 Betsy Ross Dr.
Santa Clara, CA 95054
USA
Ondamed Inc.
MED SPA / EQUIPMENT
222 ❘
USA
727-536-5566
www.hydromassage.com
408-764-3000
www.aesthetic.lumenis.com
845-496-6673
www.ondamed.net
SUMMER 2008
TO ORDER:
MEDICAL EQUIPMENT / SUPPLIES
BUYERS Guide
REVITALIGHT
119 W. Hubbard, Suite 300
Chicago, IL 60610
USA
312-527-0131
www.revitalight.com
Sciton
Palo Alto, CA 94303
and value. Sciton’s MicroLaserUSA
Peel™, ProFractional™, ProLipo™,
Body Care Resort, Inc.
1815 W. 205th St, Suite 106
Torrance, CA 90501
USA
310-782-3992
www.bodycareonline.com
Cell Science Systems-Alcat Laboratory
1239 East Newport Center Drive, #101
Deerfield Beach, FL 33442
USA
954-426-2304
www.alcat.com
Clear Mind Center
Irvine, CA 92612
USA
650-493-9146
www.sciton.com
Colonic.net
10911 West Avenue
San Antonio, TX 78213
USA
210-308-8888
www.colonic.net
Synergie By Dynatronics
7030 Park Centre Dr.
Salt Lake City, UT 84121
USA
801-568-7000
www.dynatronics.com
Cryosurgical Concepts
200 Knuth Road, Suite 204
Boynton Beach, FL 33436
USA
The Quality Life, Inc.
20-47 129th Street
College Point, NY 11356
USA
Vision Bridge
857 Post Road, Suite 319
Fairfield, CT 06824
USA
561-742-4401
www.cryo-surgical.com
917-657-3840
www.thequalitylife.com
Eclipsemed, Ltd
16850 Dallas Parkway
Dallas, TX 75248
USA
972-380-2953
www.eclipsemed.com
203-292-9162
www.thevisionbridge.com
Eidam Diagnostics Corporation
100 -13777 Commerce Parkway 604-304-6006
Richmond, BC V6V 2X3
www.eidam.com
CANADA
MEDICAL EQUIPMENT / SUPPLIES
Erchonia Medical
Arasys Perfector/
Ion Magnum LLC
7773 Waikapu Loop
Honolulu, HI 96825
USA
808-395-0656 or 866-25-YOUNG
www.ionmangum.net
224 ❘
2021 Commerce Drive
McKinney, TX 75069
USA
Infrared Sciences Corp.
1650 Sycamore Ave ,Suite 4
Bohemia, NY 11716
USA
214-544-2227
www.erchonia.com
631-240-9106
www.infraredsciences.com
KORR Medical Technologies
2463 S 3850 W Building 200
Salt Lake City, UT 84120
USA
800-483-2080
www.korr.com
SUMMER 2008
BUYERS Guide
Med-Hot Thermal
Imaging, Inc
315 Doris Drive
Lakeland, FL 33813
USA
Clean, cool, safe and patient
friendly. For cardio-vascular, breast
or full body imaging, today’s Thermography is easily integrated into
the Functional Imaging Practice.
FDA Registered, the Med-hot
HD3000 is a world-class, affordable product offering unsurpassed
beautiful hig-def images with the
greatest sensitivity in the industry
for interpreting accuracy.
American Academy of Cosmetic Physicians
8000 S Kolb Road, Suite102
Tucson, AZ 85706
USA
Living Younger Preventive-Aging Medicine & Business System
10371 N. Oracle Road, Suite 205
Oro Valley, AZ 85737
USA
520-229-1900
www.LivingYoungerPreventive-Aging.com
863-646-1599
www.med-hot.com
MedEsthetics
Magazine/Creative
Age Publications
MEDICAL PUBLICATIONS / DIRECTORIES /
MESOTHERAPY / HORMONE THERAPIES / MISCELLANEOUS
520-574-1050
www.cosmeticphysicians.org
Ondamed Inc.
USA
7628 Densmore Avenue
Van Nuys, CA 91406-204
USA
845-496-6673
www.ondamed.net
Take your medical aesthetic practice or medspa to a whole new
level. Sign up for a free subscription to MedEsthetics, the business
magazine for physicians offering
aesthetic services. Each issue features cutting-edge equipment and
products, strategic management
tools, marketing tips, industry news
and more.
800-442-5667
www.medestheticsmagazine.com
Pharmanex Antioxidant Laser Scanner
2251 North Rampart, #353
Las Vegas, NV 89128
USA
702-363-5343
www.aolscanner.com
TodayMD
Power Plate
400 Skokie Blvd.
Northbrook, IL 60077
USA
10825 NW 33rd Street
Doral, FL 33172
USA
305-629-3831
www.todaymdmarketing.com
877-87-PLATE
www.powerplatehealthcare.com
MESOTHERAPY / HORMONE THERAPIES
Sciton
and value. Sciton’s MicroLaserPeel™, ProFractional™, ProLipo™,
Palo Alto, CA 94303
USA
Scarf King
18 Meadow Lane
Roslyn Hts., NY 11577
USA
650-493-9146
www.sciton.com
Syneron
3 Goodyear Unit A
Irvine, CA 92618
USA
646-232-6105
MISCELLANEOUS
BioBancUSA
949-716-6670
www.syneron.com
5 Lower Ragsdale Drive, Suite 100 831-646-2262
Monterey, CA 93940
www.biobancusa.com
USA
Brandt Cellars International
MEDICAL PUBLICATIONS / DIRECTORIES
226 ❘
111 Stephen Street
Lemont, IL 60439
USA
630-972-1400
SUMMER 2008
Spa Management
Management is
Spa
is the
the publication
publication that
that takes
takes an
an entirely
entirely global
global view
view of
of spa.
spa.
Since its
its launch
launch in
Since
in 1991,
1991, aa period
period during
during which
which the
the industry
industry has
has taken
taken great
great strides
strides across
across
international boundaries,
international
boundaries, this
this magazine
magazine has
has become
become established
established as
as the
the most
most respected
respected voice,
voice,
and the
the most
most frequently
and
frequently referred-to
referred-to journal
journal on
on the
the international
international scene.
scene. ItIt is
is the
the magazine
magazine for
for today’s
today’s spa
spa
professional. Spa
professional.
Spa Management
Management Journal
Journal has
has grown
grown from
from 66 to
to 10
10 issues
issues aa year.
year. With
With the
the expansion
expansion comes
comes increased
increased
international news
international
news coverage
coverage and
and comment
comment on
on the
the spa
spa world
world today.
today. Spa
Spa Management
Management is
is the
the only
only magazine
magazine that
that contains
contains
in-depth profiles
profiles on
in-depth
on the
the life
life and
and works
works of
of leading
leading names
names and
and practices
practices in
in spas,
spas, and
and the
the only
only journal
journal with
with the
the necessary
necessary resources
resources
to reflect
reflect aa true
true and
to
and accurate
accurate picture
picture of
of the
the world
world of
of spas
spas with
with regular
regular input
input by
by contributors
contributors from
from around
around the
the globe.
globe.
Please complete
complete and
Please
and return
return the
the subscription
subscription form,
form, together
together with
with your
your payment,
payment,
so you
you can
can start
so
start with
with the
the next
next issue.
issue.
TO SUBSCRIBE Send to:
SPA MANAGEMENT Journal
SUBSCRIPTION DEPT.
P.O. BOX 2699
CHAMPLAIN NY 12919-2699
3 years
(30 issues)
U.S.A.
Canada
International
U.S. $99
Cdn $138
U.S. $180
2 years
(20 issues)
U.S. $69
Cdn $98
U.S. $130
1 year
(10 issues)
U.S. $39
Cdn $58
U.S. $80
NAME:
POSITION:
COMPANY:
ADDRESS:
CITY:
STATE/PROV:
COUNTRY:
ZIP:
PHONE:
FAX:
E-MAIL:
ORDERING BY FAX:
+ 1 514 274 5884
www.spamanagement.com • [email protected]
NO CREDIT OR DEBIT CARDS PLEASE
BUYERS Guide
Caregen Co., Ltd.
690-3, Caregen Bldg.
Geumjeong-dong, Gunpo-si,
Gyeonggi-do, 435-862
BioPharma
Scientific
9010 Kenamar Dr Suite 101
San Diego, CA 92121
USA
Homefirst® Health Services
2000 Golf Road
Rolling Meadows, IL 60008
USA
Key Architecture
PO Box 2296
Florence, SC 29503
USA
NUTRACEUTICALS
+82-31-452-3867
www.caregen.co.kr
South Korea
866-395-1881
www.homefirst.com
NanoGreens10 and NanoProPRP
have been shown by independent
university studies to support optimal
blood pressure and immune function. Come to booth 711 for a free
taste test and to sign up for a free
weeks supply of each. BioPharma
Scientific: Better Taste ~ Better
Science!
877-772-4362
www.nanogreens.com
843-665-6646
www.keyarc.com
Designs For Health
S-Force / Seriesse
98 S. Federal Hwy.
USA
2 North Rd.
East Windsor, CT 06088
USA
800-847-8302
www.designsforhealth.com
561-620-4798
www.laainstitute.com
Douglas Laboratories
600 Boyce Road
Pittsburgh, PA 15205
USA
Sun Labs
20550 Prairie Street
Chatsworth, CA 91311
USA
The BioMat Company
3708 NE 109th Ave., Apt. BB10
Vancouver, WA 98682
USA
The Quality Life, Inc.
20-47 129th Street
College Point, NY 11356
USA
800-245-4440
www.douglaslabs.com
Jona
800-333-6003
www.sunlabsonline.com
Fuji Health
Science
503-880-0475
libby.thebiomatcompany.net
3 Terri Lane, Suite 12
Burlington, NJ 08016
USA
Astavitapro line consists of products
positioned for maintaining a vibrant
and healthy lifestyle. Featured
product, AstaREAL Astaxanthin –
multi-functional antioxidant and has
strong anti-inflammatory activity –
is backed up by a board and continually growing body of science
as well as significant portfolio of
patents.
609-386-3030
www.fujihealthscience.com
917-657-3840
www.thequalitylife.com
Great HealthWorks, Inc.
NUTRACEUTICALS
3 Care Therapeutics, LLC
320 Kalmus Drive
Costa Mesa, CA 92626
USA
N
888-372-3421
www.omega3care.com
1890 N. University Drive, # 205
Coral Springs, FL 33071
USA
1
954-707-5080
www.greathealthworks.com
HAELEN RESEARCH FOUNDATION
18568 142nd Avenue NE, Bldg. F 425-269-7798
Woodinville, WA 98072
www.haelanresearch.org
USA
■
■
Bioenergy, Inc.
13840 Johnson St, NE
Minneapolis, MN 55304
USA
Health Secrets USA
866-267-8253
www.bioenergy.com
24141 Ann Arbor Trail
Dearborn Heights, MI 48127
USA
313-561-6800
www.healthsecretsusa.com
■
■
■
■
228 ❘
SUMMER 2008
Thi
N
EW
!
A4M
A
A4
M EDUCATIONAL PROGRAM
October 23-26, 2008 | San Diego, CA
Approved for a maximum of 29.0 Category 1 AMA PRA™ hours
Sponsored by
Medical Educator
Consortium
Presented by
American Academy of
Anti-Aging Medicine
The International
Hormone Society
Socie
Introducing The Faculty
Jonathan Wright, MD
Thierry Hertoghe, MD
Pamela Smith, MD
699
$
until
September 23, 2008*
Mark Gordon, MD
Early Bird SPECIAL!
*After September 23, registration is $899. $999 at the door.
A $100 processing fee applies to all cancellations.
4-DAY SEMINAR
■
■
■
1355 NORTH HARBOR DRIVE
SAN DIEGO, CA 92101
■
Ron Rothenberg, MD, FACEP
Thursday, October
February23rd
28th
Thursday,
Friday, October
February24th
29th
Friday,
Saturday, October
March 1st25th
Saturday,
Sunday, October
March 2nd,
2008
Sunday,
26th,
2008
Eric Braverman, MD
Add a STAFF MEMBER
for
500
$
ONLY
This CME Activity will be held at:
HOLIDAY INN, SAN DIEGO-ON THE BAY
■
Reserve Rooms on www.ucprx.com
by September 23, 2008
Cost: $189 per night
PREVENTATIVE & REGENERATIVE MEDICINE SEMINAR
A Practical Application in Treating Adult Hormone and Nutritional Deficiencies
Utilizing Advanced Testing Protocols, Bio-Identical Hormones and Nutraceuticals.
Advanced Course with Basic Introduction.
THIS COURSE WILL COVER THE FOLLOWING TOPICS!
■
■
■
■
■
■
Introduction to Treating Adult
Hormone Deficiencies
Female Bio-Identical Hormone
Replacement Therapy
The Laws & Hormone Replacement
How to Prescribe - Algorithms
for Hormone Optimization
Andropause -Treating the Adult Male
Treating Adult GH Deficiencies
■
■
■
■
■
■
Iodine: Most Misunderstood
Nutrient
Testosterone for Males & Females
Oxytocin and Sexual Orgasms
A Clinical Approach to Diagnosing
& Treating Hypothyroidism
The Importance of Hormones
& the Cardiovascular System
Case Studies on Female Hormone
Replacement
■
■
■
■
■
■
■
Nutraceuticals and Hormones
Lab Testing - Blood & Urine Testing
DHEA - Melatonin - Progesterone
- Pregnenolone - Estradiol
- Estriol - Testosterone - Cortisone
Questions & Answers for Physicians
Live Diagnosis of the Audience
Physician Networking
How to Open a HRT Practice
This course is approved by Medical Educators Consortium for a maximum of 29.0 CME credit hours toward category 1 AMA physician recognition award.
BUYERS Guide
MAX GXL
1326 Armacost Ave., Suite 5B
Los Angeles, CA 90025
USA
Metagenics, Inc
100 Avenida La Pata
San Clemente, CA 92673
USA
Mucos LLC
PHARMACEUTICAL
600 Boyce Road
Pittsburgh, PA 15205
USA
Natural Clinician, LLC
47 Center Ave.
Little Falls, NJ 07424
USA
310-478-3604
maxgxl.com/christian
800-692-9400
www.metagenics.com
PHARMACEUTICAL
Auxilium Pharmaceuticals, Inc.
40 Valley Stream Parkway
Malvern, PA 19355
USA
484-321-5900
www.auxilium.com
866-Wobenzym
www.mucos-usa.com
Bellevue Pharmacy Solutions
973-256-4660
www.naturalclinician.com
Central Drugs
1034 S. Brentwood Blvd., Suite.102
St. Louis, MO 63117
USA
520 W. La Habra Blvd.
La Habra, CA 90631
USA
314-727-8787
www.bellevuerx.com
562-691-6754
www.anypharmacy.com
Ortho Molecular Products, Inc
3017 Business Park Drive
Stevens Point, WI 54481
USA
Prescription Center
915 Hay Street
Fayetteville, NC 28305
USA
Rejuvenation Science
811 N. Catalina Ave., #3208
Redondo Beach, CA 90277
USA
T.A. Sciences, Inc.
24 E. 64th St., 5th Floor
New York, NY 10065
USA
800-332-2351
www.orthomolecularproducts.com
1109 E. Hallandale Beach Blvd. 954-455-3822
Hallandale, FL 33009
www.hallandalerx.com
USA
800-682-4664
www.rxfixer.com
888-737-3588
www.rejuvenation-science.com
XanGo International
110 N. Boulder Hwy., #120-107
Henderson, NV 89015
USA
230 ❘
KRS Global
Biotechnology,
Inc./GBTRX Inc.
791 Park of Commerce
Blvd, Suite 600
USA
KRS Global Biotechnology, Inc. announces the introduction of GBTRX,
a Premier Compounding Pharmacy. GBTRX’s mission is to provide
the highest quality compounds,
custom vitamins, IV infusions and
unsupassed customer service to
the Age-Management community.
KRS Global Biotechnology, Inc. also
introduces a NEW, All NATURAL
PRESERVATIVE FREE, Topical/Vaginal
compounding base.
888-242-7996
www.gbtrx.com
212-588-8805
www.tasciences.com
Vitamin Research Products
4610 Arrowhead Drive
Carson City, NV 89706
USA
Hallandale Pharmacy
800-877-2447
www.vrp.com
702-567-1766
www.impact2health.net
Medaus Pharmacy
2637 Valleydale Road
Birmingham, AL 35244
USA
RLC Labs, INC
2404 West 12th Street, Suite 4
Tempe, AZ 85281
USA
800-526-9183
www.medaus.com
877-797-7997
www.nature-throid.com
SUMMER 2008
BUYERS Guide
University
Compounding
Pharmacy
1875 3rd Ave.
San Diego, CA 92101
USA
UCP is a compounding pharmacy
that is board accredited by PCAB.
This certification assures that you
are getting the highest quality
compounds. UCP compounds
a wide variety of compounded
medications used in the age
management market. We deliver
anywhere in the USA. See our
website at www.ucprx.com.
619-683-2005
www.ucprx.com
Please see ad on page 27, 150
Ondamed Inc.
USA
Regenerative Sciences
6850 West 116th Ave., Unit D
Broomfield, CO 80020
USA
Technogym
830 4th Ave. S., Suite 300
Seattle, WA 98134
USA
SPORTS / FITNESS / PHYSICAL THERAPIES / STEM CELL THERAPIES
845-496-6673
www.ondamed.net
303-550-3816
www.regenexx.com
239-233-4745
www.technogymusa.com
SPORTS / FITNESS / PHYSICAL THERAPIES
STEM CELL THERAPIES
Arasys Perfector/
Ion Magnum LLC
7773 Waikapu Loop
Honolulu, HI 96825
USA
808-395-0656 or 866-25-YOUNG
www.ionmangum.net
3915 NE 38th St.
Vancouver, WA 98661
USA
Futrex, INc.
360-695-7500
130 Western Maryland Pkwy.
Hagerstown, MD 21740
USA
301-791-9220
www.futrex.com
AssureImmune
3998 FAU Blvd., Suite 215
USA
German Society for Thymus Therapy
Harvestehuder Weg 65
Hamburg, 20149
Germany
Ondamed Inc.
USA
Regenerative
Sciences
6850 West 116th Ave., Unit D
Broomfield, CO 80020
USA
Magnetico
5421- 11th St. NE, #109
Calgary, Alberta T2E 6M4
CANADA
+49-1805-849687
www.thymus-therapie.org
845-496-6673
www.ondamed.net
Regenerative Sciences Inc (RSI)
is an early stage adult stem cell
therapeutics company focused on
developing and marketing medical
procedures to treat acute and
chronic orthopedic conditions.
303-550-3816
www.regenexx.com
Magnetico Sleep Pads...Feel the
Difference in Minutes on the Demo
Bed!! Hear Dr. Bonlie’s lecture explaining magnetic science relating
to health and anti-aging. He also
invented the Magnetic Molecular
Energizer (MME) , a 10,000 lb. clinical
device, with two Phase 3 Studies
Completed - Neuropathy & Low
Back Pain. Six USA Clinics.
403-730-0883
www.magneticosleep.com
232 ❘
561-750-6030
www.assureimmune.com
Regenocyte / Regenolife
801 Laurel Oak Dr., Suite 618
Naples, FL 34103
USA
866-216-5710
www.regenocyte.com
www.regenolife.com
SUMMER 2008
1326 Armacost Ave., Suite 5 B
Los Angeles, CA 90025
USA
310-478-3604
www.3daycoloncleanse.com
Isagenix
2426 Orangewood Drive
Durham, NC 27705
USA
919-672-4862
www.gocleanse.com/bodywise
Ondamed Inc.
Arasys Perfector/
Ion Magnum LLC
7773 Waikapu Loop
Honolulu, HI 96825
USA
808-395-0656 or 866-25-YOUNG
www.ionmangum.net
866-314-4447
www.idealprotein.com
USA
845-496-6673
www.ondamed.net
Take Shape for Life/Kim Ruby Training Specialist
1828 La Force Road
Alpine, CA 91901
USA
619-238-9503
www.sandiego-hp.tsfl.com
Vita-Mix Corporation
8615 Usher Rd.
Cleveland, OH 44138-2199
USA
440-782-2557
www.vitamix.com
24141 Ann Arbor Trail, Dearborn Heights, MI 48127
TEL: 313.561.6800 FAX: 313.561.6830 www.healthsecrestsusa.com
Experience Dr. Tai’s Medical Breakthroughs specializing in:
† Anti-Aging
† Weight Management
† Sexual Vigor
† Skin Rejuvenation † Digestive Health
† Daily Well Being
† Hormone Testing
† Bioidentical Hormone Replacement
Dr. Tai helps thousands of doctors and patients with his natural, specially formulated
products and insight from years of hands on experience in the medical field! Let “the
doctor’s doctor” help you today!
SUMMER 2008
❘ 233
WEIGHT MANAGEMENT
3daycoloncleanse.com - Easy Pha-Max
178 Rue Jean Proulx, Suite 202
Gatineau, QC J8Z-1V3
CANADA
BUYERS Guide
Ideal Protein
WEIGHT MANAGEMENT
Prevention - Detection - Treatment
Age Diagnostic Laboratories is
the unsurpassed global leader
in Laboratory testing services.
By implementing the latest and
most accurate generation of
Laboratory testing equipment
and technology, we have set
the worldwide gold standard
for superior diagnostic biomedical lab testing.
• 100+ State of the Art Assays
• Standardized Test Profiles
• Customized Assays & Profiles
• Consistent with Individial Needs
• Skillfully Interpreted Practical
Experience & Reliable Data
301 NE 51st Street
Suite #2198
Boca Raton, FL 33431 USA
Phone: 561-999-1987
www.adltests.com
Our mission is to consistently
provide the industry’s most reliable, highest quality cutting
edge laboratory assays and
testing procedures and to support Health Care Providers in
their efforts to better diagnose,
treat and monitor patients.
We are committed to continuous
research and product development and a constant refinement
of our extensive menu of testing
profiles. Our goal is to provide a
steady stream of assays that set
industry standards for sensitivity,
specificity, efficiency and clinical
relevance. We design our tests to
be both reliable and cost effective.
Our easy to read reports contain
practical Interpretations that factor in the Age and Gender of the
patient and also provide suggestsuggest
ed treatment recommendations.
Coupled with their passion and
dedication, our exceptional scientific and medical staff is available
to provide guidance and consultation to health care providers regarding the significance of test results, evaluation of unusual cases
and related technical matters.
ADL is 100% committed to
provide accurate information
along with the analysis tools which
empower the health care provider
with the ability to facilitate the best
care for the patient.
PREVENTION - DETECTION - TREATMENT
We Advocate It
We Teach It
We Apply It
JOIN THE ELITE CORE
OF ANTI-AGING PHYSICIANS
3,500 & Growing
Fellowship & Board Certification
In Anti-Aging & Regenerative
Medicine Is Your
Gateway To Opportunity
“There is really only one organization that has painstakingly developed the
educational programs and, thereby, has given Physicians worldwide, an opportunity
to become experts in the field of anti-aging and aesthetic medicine. The A4M, in its
tireless efforts to continue its leadership in regenerative medicine education, now
offers courses to compliment oral nutrition and detoxification teaching Physicians
how to incorporate IV nutrition directly into their own practice.”
Mitchell J. Ghen, D.O., Ph.D.
Medical Director,
Age Diagnostic Laboratories
Medical Director, Centers of Anti-Aging
and Longevity Medicine
To Register for the American Board of Anti-Aging and
Regenerative Medicine Fellowship & Board Certification Program, contact:
American Academy of Anti-Aging Medicine
301 Yamato Road • Boca Raton, FL 33431
Tel: (800) 558-1267 • Fax: (561) 997-0287
email: [email protected]

Buyers Guide - American Academy of Anti

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