Current Stage
Transcription
Current Stage
Alcon innovation – Accelerating Growth Kevin Buehler Alcon Division Head Investor Day London, 22 November 2013 Disclaimer This presentation contains forward-looking statements that can be identified by terminology such as such as “potential,” “expected,” “will,” “planned,” or similar expressions, or by express or implied discussions regarding potential new products, potential new indications for existing products, or regarding potential future revenues from any such products; the potential completion of the divestiture of the Novartis blood transfusion diagnostics unit; potential shareholder returns or credit ratings, the potential outcome of the share buyback being initiated; or regarding potential future sales or earnings of the Novartis Group or any of its divisions; or by discussions of strategy, plans, expectations or intentions. You should not place undue reliance on these statements. Such forward-looking statements reflect the current views of the Group regarding future events, and involve known and unknown risks, uncertainties and other factors that may cause actual results to be materially different from any future results, performance or achievements expressed or implied by such statements. There can be no guarantee that any new products will be approved for sale in any market, or that any new indications will be approved for any existing products in any market, or that any approvals which are obtained will be obtained at any particular time, or that any such products will achieve any particular revenue levels. Nor can there be any guarantee that the proposed divestiture of the blood transfusion diagnostics unit will be completed in the expected form or within the expected time frame or at all. Nor can there be any guarantee that Novartis will be able to realize any of the potential strategic benefits, synergies or opportunities as a result of the divestiture. Neither can there be any guarantee that shareholders will achieve any particular level of shareholder returns or regarding the potential outcome of the share buyback being initiated. Nor can there be any guarantee that the Group, or any of its divisions, will achieve any particular financial results or any particular credit rating. In particular, management's expectations could be affected by, among other things, unexpected regulatory actions or delays or government regulation generally, including an unexpected failure to obtain necessary government approvals for the transaction, or unexpected delays in obtaining such approvals; the potential that the potential strategic benefits, synergies or opportunities expected from the transaction may not be realized or may take longer to realize than expected; the inherent uncertainties involved in predicting shareholder returns or credit ratings; unexpected clinical trial results, including additional analyses of existing clinical data or unexpected new clinical data; the Group's ability to obtain or maintain patent or other proprietary intellectual property protection, including the ultimate extent of the impact on the Group of the loss of patent protection and exclusivity on key products which commenced last year and will continue this year; unexpected product manufacturing and quality issues, including the resolution of the Warning Letter issued to us with respect to three Sandoz manufacturing facilities, and the completion of efforts to restart production of certain products formerly produced at the Consumer Health manufacturing facility at Lincoln, Nebraska, and the restructuring efforts at that site; government, industry, and general public pricing pressures; uncertainties regarding actual or potential legal proceedings, including, among others, actual or potential product liability litigation, litigation and investigations regarding sales and marketing practices, shareholder litigation, government investigations and intellectual property disputes; competition in general; uncertainties regarding the effects of the ongoing global financial and economic crisis, including the financial troubles in certain Eurozone countries; uncertainties regarding future global exchange rates; uncertainties regarding future demand for our products; uncertainties involved in the development of new healthcare products; the impact that the foregoing factors could have on the values attributed to the Group's assets and liabilities as recorded in the Group's consolidated balance sheet; and other risks and factors referred to in Novartis AG's current Form 20-F on file with the US Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described herein as anticipated, believed, estimated or expected. Novartis is providing the information in this presentation as of this date and does not undertake any obligation to update any forward-looking statements as a result of new information, future events or otherwise. | Investor Day | 22 November 2013 | Agenda Perspectives post-merger Surgical: transformational innovation for patients and clinicians Ophthalmic Pharmaceuticals: near and long-term drivers Vision Care: now a critical mass competitor Looking ahead and Conclusions 59 | Investor Day | 22 November 2013 | Substantial innovation since merger Timing of Value Driver Franchise Near-Term Glaucoma combinations Ophthalmic Pharmaceuticals offsetting generic pressures Enter retina space: Jetrea® Longer-Term (>3 years) NIBR integration with program acceleration Novel NMEs: ESBA 1008 and complement inhibitors Launch of Centurion® phacoemulsification system Surgical Launch of Cataract Refractive Increasing AT-IOL penetration Emerging Markets conversion to Phaco Suite™ Successful integration of lens Broaden portfolio to fill gaps care and contact lens portfolio Vision Care New product launches in key segments Cost synergies of USD 370 m Integration into Novartis and business realignment 60 | Investor Day | 22 November 2013 | Completion Underway Eyecare remains attractive with projected growth in mid-single digits Projected industry sales USD bn Drivers 49 +4% 11 Vision Care 13 Surgical 37 9 +7% 9 +5% 25 19 2013 +5% Shift towards disposable contact lenses Shift towards SiHy material Emerging market penetration Cataract procedure growth Adoption and penetration of AT-IOLs New equipment platforms Ophthalmic Continued expansion of Retina therapies Pharmaceuticals Growth in glaucoma combinations offset by LOEs Unit volume driven by aging demographics 2018 Source (1) Contact Lens and Lens Care estimates Contact Lens Institute/Euromcontact Factory Sales Sharing Program/GfK/Internal Estimates; Market definition limited to Soft lens, and disinfectant solutions (2) Pharmaceuticals estimates according to IMS MIDAS, 2012 (3) Surgical estimates according to 2013 Market Scope, LLC Forecasts (4) Retina Rx from Evaluate Pharma estimations, 2013 (5) Vitamins estimates based on Nielsen, Japan Euromonitor, and IMS GlobalTrak. 61 | Investor Day | 22 November 2013 | Agenda Perspectives post-merger Surgical: transformational innovation for patients and clinicians Ophthalmic Pharmaceuticals: near and long-term drivers Vision Care: now a critical mass competitor Looking ahead and Conclusions 62 | Investor Day | 22 November 2013 | Ophthalmic surgical: attractive space multiple facets driving growth Industry Growth Drivers Projected 2013 surgical industry sales in USD bn Cataract Projected Alcon CAGR Position 13-18 7.2 7% Rising global cataract procedures Increasing AT-IOL penetration Increasing adoption of phacoemulsification #1 Alcon Growth Drivers Vitreoretinal Refractive 1.0 0.5 Total 5% #1 4% #2 7% Launch of Centurion® Vision System for phacoemulsification Launch of Cataract Refractive Suite™ Focus on Toric AT-IOLs Smaller incision, preloaded IOL launch Phacoemuslification development Source: Surgical estimates according to 2013 Market Scope, LLC Forecasts, Internal estimates 63 | Investor Day | 22 November 2013 | Demographic trends plus innovation expected to deliver surgical growth Illustrative Projected Alcon Surgical Growth Cataract Refractive Suite™ launch IOL upgrades Centurion® Vision System ~ 5% Procedure Growth 64 | Investor Day | 22 November 2013 | Equipment Share and Price AT-IOL Penetration Continued innovation in surgical expected to further patient and surgeon needs Market expansion Surgical LenSx® ReSTOR® 2.5D Intrepid® Femtosecond cataract laser Multi-focal Intraocular Lens Minimally Invasive Intraocular Lens Luxor® LX3 Verion™ Integration Microscopes LenSx and Centurion® Centurion® Phacoemulsification EX500® / FS200® Refractive surgery lasers Ophthalmic Pharmaceuticals Short Term (<3 years) Simbrinza® Glaucoma Dailies Total1® SiHy Lens 1sVMA= symptomatic Vitreomacular Adhesion = Geographic Atrophy 3AMD = Age-related Macular Degeneration 4DACP = Dailies Aqua Comfort Plus ® 5DT1 = Dailies Total 1® 6WG = Water Gradient 2GA 65 | Investor Day | 22 November 2013 | Accommodative Next generation Intraocular Lens Vitreo-retinal system Discussed Today ReSTOR® Toric Intraocular Lens LD Travoprost Glaucoma HD Olopatadine Allergy Jetrea® sVMA1 Vision Care Longer Term (>3 years) ESBA 1008 Wet AMD3 PDE IV Allergy DACP4 Toric HEMA lens AirOptix® Color SiHy Lens DACP4 Multifocal HEMA lens Replenish® w/ ESBA1008 Wet AMD3 Complement Inhibitor GA2 DT15 Multifocal SiHy Lens DT15 Toric SiHy Lens DT15 Colors SiHy Lens Weekly WG6 SiHy Lens Centurion® is expected to allow Alcon to expand its leading position in phaco equipment Key Differentiators Key Differentiators “Active Fluidics” – Improvement in Intraocular Pressure (IOP) stability Intuitive Touch Screen Graphic User Interface VERION™ Link Current Stage Current Stage CE mark and FDA approval in late 2012 Commercial launch Q4 2013 66 | Investor Day | 22 November 2013 | Alcon offers a range of base and advanced technology IOLs Base IOL Comparison Advanced technology Product Description Value 67 base monofocal USD Base Value | Investor Day | 22 November 2013 | smaller incision Base Value+ addresses astigmatism 3x Base Value addresses presbyopia 5x Base Value addresses astigmatism and presbyopia 7x Base Value Intrepid® IOL platform offers the ability to provide smaller incision size Key Differentiators Key Differentiators Real sub 2mm procedure Maintains wound integrity • Less damage to corneal endothelium • Less surgically induced astigmatism Preloaded to reduce handling Compatible with AUTOSERT™ IOL Injector Centurion® and INFINITI® Systems Current Stage Current Stage Targeted launch expected in H1 2014 68 | Investor Day | 22 November 2013 | Innovation in Multi-Focal IOLs ReSTOR® Toric ReSTOR® 2.5D Key Differentiators Key Differentiators Corrects astigmatism and Shift light energy to the distance presbyopia Provides broadest range (nearintermediate-distance) of vision High level of spectacle independence Improves quality of both distance and intermediate vision Potentially reduces halo and glare Current Stage Current Stage US and Japan launch expected Launched in EU in Q3 2012 Clinical trials ongoing to support in 2nd half of 2014 Commercially available in all other markets 69 image | Investor Day | 22 November 2013 | US filing An unmet need exists to help provide better refractive outcomes for cataract patients... In the Clinic Preoperative measurement Surgical planning and IOL selection ~40% of cataract patients have >1D of astigmatism1 1 W Hill Keratometry database 70 | Investor Day | 22 November 2013 | During Surgery Marking for lens alignment Precise placement Aiding in these steps can drive better patient outcomes ... which can be improved through an integrated approach to surgical planning Elements of the Cataract Refractive Suite™ Pre-operative imaging and planning Femtosecond laser for incisions and to soften lens LenSx® disposables 71 | Investor Day | 22 November 2013 | AT-IOLs Superior intra-operative visualization New phacoemulsification platform enhancing control Procedure Items The launch of the Cataract Refractive Suite™ could shift the paradigm in cataract surgery Video on Verion™ Image Guided System is shown at the event 72 | Investor Day | 22 November 2013 | Plans to increase the Toric AT-IOL penetration Penetration of clinically eligible > 1D astigmatism procedures Plan to Improve Toric Penetration 50% Maximize patient access by market Build clinical confidence via 40% technology (e.g. VERION™, ReSTOR® Toric, ReSTOR® 2.5D Toric) 30% Patient engagement 20% 10% Australia US Japan France Brazil Germany Italy Sources: (1) 2013 Global IOL Report (Market Scope) (2) W Hill Keratometry database (3) AcrySof IQ ReSTOR Multifocal IOL DFU Warnings/Precautions. Schmier et al. Evaluation of Medicare Costs of Endophthalmitis among Patients after Cataract Surgery. Ophthalmology 2007 73 | Investor Day | 22 November 2013 | Patient engagement could make a step change in treatment FreedomFromCataracts.com EyeFile Registration Site registration including personalization and opportunities to opt-in for additional information 74 | Investor Day | 22 November 2013 | Surgeon Locator Patient Information Kit Local search for surgeons that perform AT-IOL procedures and use femtosecond lasers Information related to disease awareness, treatment options, and physician discussion guide Phaco Development in Emerging Markets Px 1.3M Penetration* % Phaco 0.8% Goals Status in 2013 Increase penetration – by building surgical capacity Program trained surgeons performed 111k procedures 70% Standardized phaco development program China 6.3M 6.8% 24% Increase usage of phaco emulsification Partnerships with private and government teaching centers India 455k 0.2% 89%** Increased penetration by building surgical capacity and patient access to capable Phaco surgeons 3.5M 6.0% 99% Standard of care for cataract procedures Russia US * Procedure penetration in >60 year olds as estimated by UN Population Division Source: Market Scope 2013 ; **internal estimate 75 Program trained surgeons performed 76k procedures | Investor Day | 22 November 2013 | 4 Pilots focused on high potential underserved regions Surgical Summary Surgical expected to grow faster than the industry driven by Expected tailwinds from cataract procedure growth from demographics and emerging markets Focus on patient outcomes Expected increase in toric AT-IOL penetration 76 | Investor Day | 22 November 2013 | Agenda Perspectives post-merger Surgical: transformational innovation for patients and clinicians Ophthalmic Pharmaceuticals: near and long-term drivers Vision Care: now a critical mass competitor Looking ahead and Conclusions 77 | Investor Day | 22 November 2013 | Ophthalmic pharmaceuticals: attractive opportunities expected to offset generic pressures Projected CAGR Alcon Projected 2013 pharmaceutical 13-18 Position industry sales in USD bn Glaucoma Infection Inflammation Dry Eye Allergy Otic 5.2 0% #1 Industry Growth Drivers New Retinal approvals and unmet clinical need Limited Glaucoma NME innovation and generic pressure Aging demographics drive unit volume Emerging market adoption of Rx technology 2.7 2.2 Total #1 3% #2 5% 2.1 Retina 3% #1 Alcon Growth Drivers Jetrea® – new standard of treatment for VMT Combination Glaucoma growth – OUS and Simbrinza® opportunity 6.4 11% 5% #1* Growth potential for palliative dry eye treatment – Systane® Pipeline opportunities in anti-VEGF and Complement Factor – POC stage * Including Lucentis® Source: Pharmaceuticals estimates according to IMS MIDAS, 2012; Retina Rx from Evaluate Pharma estimations, 2013 78 | Investor Day | 22 November 2013 | Combination glaucoma is expected to be a growth driver for Alcon Projected contribution to global glaucoma sales (Illustrative) DuoTrav® and Azarga® combinations continuing to drive growth ex-US 100% 2013 Japan Azorga® approval Monotherapies (Travatan®, Azopt®) Simbrinza®: • First beta-blocker free combination in US • Treatment option for systemic risk patients • US approval May 2013 • EU launch expected 2014 Combinations (Duotrav®, Azarga®, Simbrinza®) 2013 79 2018 | Investor Day | 22 November 2013 | Assessing surgical intervention technologies Simbrinza® Creates New Treatment Possibilities Simbrinza®: beta-blocker-free/ timolol-free fixed dose combination Provides additional treatment possibilities for patients that cannot tolerate beta blockers 1 Market US EU Regulatory FDA approval April 2013 EU submission June 2013 Dosage TID1 BID2 IOP lowering (%, mmHg) 23-35% 6-9 mmHg 25-37% 7-10 mmHg TID – Three times daily 2 BID – Twice daily Source: G. Katz, JAMA Ophthalmol, April11, 2013, “Three month randomized trial of Fixed Combination Brinzolamide, 1%, and Brimonidine, 0.2% 80 | Investor Day | 22 November 2013 | Systane® franchise expected to continue to drive growth Alcon Dry Eye Sales In USD m Market Growth Drivers Aging population and increasing 600 disease awareness +9% Under-penetration as currently 1 in 10 seek treatment 400 Alcon Growth Drivers 200 Portfolio: Expand Systane® portfolio across lubricating agents and preservative options 0 2010 2011 2012 Exceeds estimated industry growth of 4% 81 | Investor Day | 22 November 2013 | Professional Demand: Increase trial via professional recommendation OTC: Increase retail and consumer awareness Jetrea® will offer eligible patients an option beyond watchful waiting and surgery Diagnosis Indication Clinical Results Jetrea® indicated for treatment of VMT including when associated with macular hole ≤400μm 26.4% resolution at 28 days across indicated population Visual acuity Loss Vitreomacular traction and macular hole Source: Stalmans P et al. N Engl J Med 2012; 367: 606-15; Data on file 82 | Investor Day | 22 November 2013 | A multi-prong strategy is being executed to develop the market for Jetrea® Completion Underway Drive best in class launch Creating the market for new treatment approach Registration with label Demand creation to complete retina community collaboration with Novartis Ophthalmics Market Access: Positive NICE and IQWiG assessment Real-world data generation: Patient registry and Phase IV Clinical data with efficacy Estimated 250-300K patients in EU IQWiQ - Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (Institute for Quality and Efficiency in Healthcare) Source: Novartis estimates 83 | Investor Day | 22 November 2013 | Ophthalmic Pharmaceuticals portfolio conversion expected to drive growth, with LOE1 risk Projected global sales potential Combination glaucoma growth and Illustrative share expansion (e.g. Duotrav®, Azarga®, Simbrinza®) Jetrea® • Acceleration with clinical experience Strategic Brands & Pipeline and reimbursement • Global launches Global expansion of the Systane® dry eye franchise Potential upsides with ESBA 1008 and complement inhibitors Retinal Pharmaceutical drug delivery - LOE1 Brands 2013 2018 1 Loss of Exclusivity in Glaucoma and Allergy Replenish is a trademark of Replenish, Inc 84 Replenish™ | Investor Day | 22 November 2013 | Pipeline with late term retinal opportunities Market expansion Surgical LenSx® ReSTOR® 2.5D Intrepid® Femtosecond cataract laser Multi-focal Intraocular Lens Minimally Invasive Intraocular Lens Luxor® LX3 Verion™ Integration Microscopes LenSx and Centurion® Centurion® Phacoemulsification EX500® /FS200® Refractive surgery lasers Ophthalmic Pharmaceuticals Short Term (<3 years) Simbrinza® Glaucoma Dailies Total1® SiHy Lens 1sVMA= symptomatic Vitreomacular Adhesion = Geographic Atrophy 3AMD = Age-related Macular Degeneration 4DACP = Dailies Aqua Comfort Plus ® 5DT1 = Dailies Total 1® 6WG = Water Gradient Replenish is a trademark of Replenish, Inc 2GA 85 | Investor Day | 22 November 2013 | Accommodative Next generation Intraocular Lens Vitreo-retinal system Discussed Today ReSTOR® Toric Intraocular Lens LD Travoprost Glaucoma HD Olopatadine Allergy Jetrea® sVMA1 Vision Care Longer Term (>3 years) ESBA 1008 Wet AMD3 PDE IV Allergy DACP4 Toric HEMA lens AirOptix® Color SiHy Lens DACP4 Multifocal HEMA lens Replenish® w/ ESBA1008 Wet AMD3 Complement Inhibitor GA2 DT15 Multifocal SiHy Lens DT15 Toric SiHy Lens DT15 Colors SiHy Lens Weekly WG6 SiHy Lens ESBA 1008 has the potential to augment wet AMD therapies Key Differentiators Key Differentiators Potentially longer duration of action versus currently marketed anti-VEGFs Single chain antibody fragment (scFv) smaller than a Mab or Fab Suitable for delivery via intravitreal treatment or sustained drug delivery Current Stage Current Stage Phase II in Wet AMD Potential for three VEGF-dependent indications (wet AMD1, DME2, RVO3) ® 1AMD – Age related Macular Degeneration – Diabetic macular edema 3RVO – Retinal vein occlusion 2DME 86 | Investor Day | 22 November 2013 | Replenish® drug delivery pump may provide an alternative to intravitreal injection Key Differentiators Fully programmable, refillable pump Versatile, can be used with multiple drugs and formulations Rechargeable to support chronic use Applicable to back of the eye disorders Current Stage Current Stage Collaborating with leading technology firm First-in Human (FIH) study complete Next step: Replenish®/ESBA1008 Proof-ofConcept Replenish® is a trademark of Replenish, Inc 87 | Investor Day | 22 November 2013 | Opportunity for Alcon to enter +USD 6 bn new category Projected Global Sales for Wet AMD, DME and RVO Therapies In USD bn Continued growth projected, driven by new indications +10% 10.2 Expanding clinical experience and market access RVO DME 6.4 Significant unmet need with need for new NME treatments wAMD Dose reduction and convenience technologies are needed 2013 1 Evaluate Pharma 88 | Investor Day | 22 November 2013 | 2018 LFG316 Complement Inhibitor for Geographic Atrophy Key Differentiators Advanced form of dry AMD (~8 m patients WW) characterized by the permanent blind spots in a patient’s central vision1 No therapy exists for treatment Potential to treat total population vs. subpopulation with better response to treatment Current Stage Phase I ongoing, expected 2014 readout 1. Rudnicka, A. et al,"Age and Gender Variations in Age-related Macular Degeneration Prevalence in Populations of European Ancestry: A Meta-analysis,"Ophthalmology, 2012; 119:571–580. 89 | Investor Day | 22 November 2013 | Ophthalmic Pharmaceuticals summary Ophthalmic Pharmaceuticals will be driven by portfolio conversion Shift to combination glaucoma Continued growth of Systane® for dry-eye Progress in positioning Jetrea® as standard of care Innovation in retina treatments 90 | Investor Day | 22 November 2013 | Agenda Perspectives post-merger Surgical: transformational innovation for patients and clinicians Ophthalmic Pharmaceuticals: near and long-term drivers Vision Care: now a critical mass competitor Looking ahead and Conclusions 91 | Investor Day | 22 November 2013 | Alcon Vision Care unit fully aligned to capture growth opportunities Industry Growth Drivers Shift to products with better outcomes Projected 2013 Vision Care industry sales in USD bn Projected CAGR Alcon 13-18 Position (daily SiHy) Unmet need in comfort, vision, and health Emerging growth markets in Asia Soft Lenses Lens Care 7.6 1.4 Total 4% 1% 4% #2 #1 Alcon Growth Drivers Portfolio and Brand Development • Re-launch and rebranding of Dailies Aqua Comfort Plus® • Launch of AirOptix® Colors • Expansion of Dailies Total1® globally Focus on Japan Vision Care Source Contact Lens and Lens Care estimates Contact Lens Institute/Euromcontact Factory Sales Sharing Program/GfK/Internal Estimates; Market definition limited to Soft contact lens, and disinfectant solutions 92 | Investor Day | 22 November 2013 | Dailies Aqua Comfort Plus® portfolio expansion Key Differentiators Key Differentiators Add Toric and Multi-focal options Full brand family Current Stage Current Stage Regulatory approval received for Multi-Focal and Toric US, EU, Japan, Canada, and Australia launch planned for H1 2014 93 | Investor Day | 22 November 2013 | AirOptix® Colors to complete brand portfolio Key Differentiators Key Differentiators Provides breathable SiHy lens to consumers interested in color options Combines plasma surface with realistic color blend technology Current Stage Current Stage CE mark received October 2013 FDA submission in October 2013 94 | Investor Day | 22 November 2013 | Continued expansion of Dailies Total1® in Premium/Water Gradient SiHy segment... Comfort continues to be the No. 1 need among contact lens wearers. Nearly 1 of 6 patients eventually discontinue use due to discomfort and dryness LightStream® Lens Technology Water gradient Silicone Hydrogel Material Chemistry 95 | Investor Day | 22 November 2013 | DAILIES TOTAL1® water gradient contact lenses have the highest surface lubricity and breathability of any contact lens delivering a new era in comfort ...is expected to deliver continued share gains... Early Results in Daily Disposable SiHy Sphere Segment 1D TruEye DT1 Italy DD1 SiHy Sphere Revenue share percentage +14 60 #1 Daily Disposable premium lens 40 20 Oct Nov Dec Jan Feb Mar Apr May Jun Jul Aug Sep 2012 2012 2012 2013 2013 2013 2013 2013 2013 2013 2013 2013 US DD SiHy Sphere Revenue share percentage 100 50 +20 +20 share points growth with early limited launch 0 Oct Nov Dec Jan Feb Mar Apr May Jun Jul Aug Sep 2012 2012 2012 2013 2013 2013 2013 2013 2013 2013 2013 2013 1DD 96 SiHy – Daily Disposable Silicon Hydrogel | Investor Day | 22 November 2013 | ... and Alcon is building capacity to grow globally Production Capacity of Dailies Total1® Millions of Units 1 200 +45% Currently, Dailies Total1® is constrained by capacity To meet demand, Alcon is investing to build capacity 0 2013 97 2014 | Investor Day | 22 November 2013 | 2015 2016 2017 2018 Japan represents considerable opportunity G7 US Japan EU Top 5 2,651,237 709,057 1,058,756 883,423 24% 37% 8% 35% Latest 12 months - JUNE 2013 Daily Disposable CLEAR USD '000 ALCON Share Percentage World’s largest dailies market Near-Term Portfolio Launches Dailies Total1® DACP® Professional DACP® Multifocal and Toric Air Optix® Colors Source: GfK G7 Retail excluding Walmart June 2013 98 | Investor Day | 22 November 2013 | Execution Sales force expansion Messaging Channel pricing Full Vision Care portfolio is key to category leadership Market expansion Surgical LenSx® ReSTOR® 2.5D Intrepid® Femtosecond cataract laser Multi-focal Intraocular Lens Minimally Invasive Intraocular Lens Luxor® LX3 Verion™ Integration Microscopes LenSx and Centurion® Centurion® Phacoemulsification EX500® /FS200® Refractive surgery lasers Ophthalmic Pharmaceuticals Short Term (<3 years) Simbrinza® Glaucoma Dailies Total1® SiHy Lens 1sVMA= symptomatic Vitreomacular Adhesion 2GA = Geographic Atrophy 3AMD = Age-related Macular Degeneration 4DACP = Dailies Aqua Comfort Plus ® 5DT1 = Dailies Total 1® 6WG = Water Gradient 99 | Investor Day | 22 November 2013 | Accommodative Next generation Intraocular Lens Vitreo-retinal system Discussed Today ReSTOR® Toric Intraocular Lens LD Travoprost Glaucoma HD Olopatadine Allergy Jetrea® sVMA1 Vision Care Longer Term (>3 years) ESBA 1008 Wet AMD3 PDE IV Allergy DACP4 Toric HEMA lens AirOptix® Color SiHy Lens DACP4 Multifocal HEMA lens Replenish® w/ ESBA1008 Wet AMD3 Complement Inhibitor GA2 DT15 Multifocal SiHy Lens DT15 Toric SiHy Lens DT15 Colors SiHy Lens Weekly WG6 SiHy Lens Vision Care summary Vision Care will focus on Innovation in building a differentiated portfolio Commercial execution in opportunity areas 100 | Investor Day | 22 November 2013 | Agenda – Perspectives post-merger Surgical: transformational innovation for patients and clinicians Ophthalmic Pharmaceuticals: near and long-term drivers Vision Care: now a critical mass competitor Looking ahead and Conclusions 101 | Investor Day | 22 November 2013 | Summary – Projected revenue growth Surgical New Phaco technology Toric IOL penetration - Verion™ surgical planning Intrepid® mono-focal IOL Ophthalmic Pharmaceuticals Jetrea® penetration and new treatment approach Retinal Rx entry Vision Care Global Dailies Total1® portfolio launch Japan share development New SiHy weekly portfolio 102 | Investor Day | 22 November 2013 | Summary Ophthalmology continues to be an exciting space for growth driven by: •Favorable demographics •Innovation •Emerging Markets Alcon expected to grow faster than the industry in all franchises 103 | Investor Day | 22 November 2013 |