Diapositiva 1 - Informatori.it

Transcription

International urgency for control and
containment of environmental and
climatological damage that produces the
disappearance of natural medicines
Urgenza internazionale per il controllo e il contenimento del
danno ambientale e climatologico che produce la scomparsa delle
medicine naturali
Prof. Giancarlo Pantaleoni
Dean of the Faculty of Medical Sciences
L.U.de.S. Lugano ( CH)
Key words: PCBs; Halogenated Hydrocarbons; behavioral teratogenesis; climatic changes
and environmental agents; medicinal plants disappearance; Vittorio Erspamer; microdialysis;
Urban Ungerstedt; rehabilitation; antiaging; delivery systems; nanotechnologies; medical
biotechnology.
12/09/2015
Prof. G. Pantaleoni L.U.de.S.
University - Lugano (CH)
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The Eukaryotic Kingdom (plants, animals, humans) evolved and adapted to
various conditions of the planet, in collaborative harmony.
L'eucariotica Unito (piante, animali, esseri umani) si è evoluto e adattato alle
diverse condizioni del pianeta, in armonia collaborativa.
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The basic behaviours for the survival of
all living species:
1.the Taxis (+ or -);
2.the Defence (active and passive);
3.the Collaboration,
...are included in all eukaryotic DNA ( plants,
animals, humans !!!)
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PROCARIOTIC CELL
COLLABORATION !!!
MITOCONDRIAS
Nuestros amigos MITOCONDRIAS !!!
= Eucariotic
Cells !.Well organized to
build a living organism: plants, animals, humans!
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Because of this good organization of
eukaryotic cells collaborating together in
a living organism, we can now speak of
Endogenous Pharmacology (the old “vis
medicatrix naturae” ) especially after the
discoveries of our Prof. Vittorio Erspamer
(serotonin and The peptide triangle).
But ATTENTION! We are finding that eukaryotic
cells collaborate together even if they belong to
different living organisms (plants, animals, and
humans) !!!
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This is one great scientific
discovery!
A Universal Law entered into the
DNA of any eukaryotic cell
(Collaboration …), that unites,
to the survival of the species,
both vegetable and animal
kingdom !!!
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For this Universal Law … our
planet has a huge wealth of
active ingredients of medical interest,
contained
1.in plant
2. in animal organisms and their
extracts !!!
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Many of these were identified ....
spontaneously .(!)...by the people who have
used them therapeutically and empirically
(Ethnomedicine).
Cuba and all Latin America has a huge
plant and animal biodiversity and possibly…
“the wider pool of medicinal plants in the
world”.
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L’ Amazzonia peruviana
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Sierra del Rosario Biosphere Reserve, Cuba
Photograph by © WWF-Canon / Michel ROGGO
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More than 8000 species of plants are present in
Cuba, over half of them endemic.
The portion of Cuba covered by forests
declined from
90% in 1812
to 54% in 1900
to only 14% in 1959.
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Of this, 43% is semideciduous forest, 31%
mangroves, 12% pines, and only 1.5% tropical rain
forest.
The areas where the endemic fauna is least
disturbed are the swamps of southern Matanzas, the
mountainous areas, and the offshore islands of the
five main archipelagos.
Apart from the sea creatures, the most abundant
representativos of the Cuba's fauna are reptiles,
including crocodiles, iguanas, lizards,
salamanders, sea turtles and 15 species of non
poisonous snakes.
http://micasacubana.com/insidecuba.htm
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Cuban moist forests (NT0120) Sierra del Rosario Biosphere Reserve, Cuba.
Photograph by © WWF-Canon/Michel ROGGO
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In relation to scientific evidence on drug
and toxicological addiction we begin to
believe that ...
total extracts of a plant may be beneficial
for organisms to humans and animals
more than pharmacological activity of
individual molecules contained therein.
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The study of “receptor interdependence”
….with the discovery of numerous neurotransmitters
and neuromodulators also largely identified, as I said
before.. in mammals, ….by Prof. Vittorio Erspamer :
Enteramin = Serotonin ( …now discovered also
in many plants..)
and
The peptide Triangle
… must
be coordinated in multidisciplinary studies in
these areas, for several reasons:
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1)progressive disappearance of plant and animal
species.
2) Studies on stem cells.
3) Studies on cancer and/or rehabilitation of
disabilities and antiaging methods.
4) Studies of molecular and cellular medical
biotechnology.
5) Studies on nanotechnology also as delivery
systems of drugs.
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Scientific research in Pharmacology
must now more than ever, strengthened
in the study of interrelationships
between the world eukaryotic,
organismic and interspecies.
Molecules predominantly laevogyrate
of natural kingdoms have also allowed
adjustments corresponding receptor
specific and genetically transmitted.
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The industrial synthesis of natural molecules
also produce molecules dextrogyrae (50% of
racemic), which may affect eukaryotic receptor
molecules evolved with mostly natural
laevogyrate.
The study of cells interrelationships today
can usefully benefit from the discoveries of
Microdialysis as organized by Prof. Urban
Ungerstedt of Karolinska Institutet in Stockholm.
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SONDAS MICRODIALISIS “CMA 12 ELITE”
Diseñadas para trabajo en CNS, permiten
implantación crónica y se pueden usar con su
correspondiente cánula guía.
Disponibles en membrana, poliarilathersulfonico
(PAES), con un cut off de 20.000 D
La membrana se puede seleccionar entre 1, 2, 3 ó 4
mm de longitud.
El diámetro de la membrana es de 0.5 mm.
Diámetro de tubo de acero 0.64 mm. Longitud del tubo
de acero 14 mm.
Se almacenan en seco, pueden conservarse durante 2
años, esterilizables por oxido de etileno.
Paq. de tres unidades
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At this basic problem of …
“biochemical receptor organization of eukaryotic organisms (plants,
animals, humans) and their interrelationship collaborative balances,
must be added today….
“the biochemical and genetic dangers of natural
products from environmental pollutants”…
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Many of them produce:
a) Climatological balance changes with biochemical and
functional effects of plants and animals expanded and genetically transmissible
(mutations).
b) Accumulation
in lipid rich tissues (brain and gonads),
with problem of behavioral teratogenesis, and then threats to
the survival of many animal species including
humans…!!!
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DNA Mutations
What causes DNA
mutations?
1. DNA damage from
environmental agents
such as ultraviolet light
(sunshine), nuclear radiation
or certain chemicals.
2. Mistakes that occur when a
cell copies its DNA in
preparation for cell division.
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Fundamental and Applied Toxicology
Volume 11, Issue 3, October 1988, Pages 440-449
doi:10.1016/0272-0590(88)90108-X | How to Cite or Link Using DOI
Copyright © 1988 Published by Elsevier Inc. Cited By in Scopus (57)
Permissions & Reprints
Effects of maternal exposure to
polychlorobiphenyls (PCBs) on F1 generation
behavior in the rat
(BEHAVIORAL TERATOGENESIS)
This article is not included in your organization's subscription. However, you may be
able to access this article under your organization's agreement with Elsevier.
Giancarlo Pantaleoni, Donatella Fanini, Anna Maria Sponta, Giancarlo
Palumbo, Raffaele Giorgi and Perrie M. Adams
a Department of Internal Medicine and Public Health, Chair of Pharmacology, School
of Medicine, L'Aquila, Italy
b The University of Texas Health Science Center, Dallas, Texas, USA
Received 20 October 1987;
accepted 6 April 1988. Available online 27 September 2004.
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Hacia 1987 se 27 países firmaron un tratado mundial ambiental
para remediar la situación, … el Protocolo de Montreal para
Reducir las Sustancias que Destruyen la Capa de Ozono (que
incluye CFC-11, -12, -113, -114, -115 y los halones, que son
sustancias que micas utilizadas para extinguir el fuego),
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Seasonal variation of tropospheric NO2 vertical column over Europe derived
from GOME measurements. (Waning, University of Heidelberg, 2001)
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http://www.inchem.org/documents/ehc/ehc/ehc126.htm
Cardiovascular and respiratory function studies of HCFC 22
in different animal species
1. Effects of exposure Rat decreased heart rate, changes
myocardial contractility and produce arterial hypotension
.Pantaleoni & Luzi (1975a) / Pantaleoni & Luzi (1975b)
[Toxicity of aliphatic halogenated hydrocarbons containing
fluorine]
Pantaleoni G, Zoccolillo L.
Ann Ist Super Sanita. 1977;13(1-2):343-51. Italian. PMID: 603132 [PubMed - indexed
for MEDLINE]
Related citations
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1. On-line analysis of volatile chlorinated hydrocarbons in air by gas
chromatography-mass spectrometry Improvements in
preconcentration and injection steps.
Zoccolillo L, Amendola L, Insogna S, Pastorini E.
J Chromatogr A. 2010 Jun 11;1217(24):3890-5. Epub 2010 May 3.PMID:
20444461 [PubMed - indexed for MEDLINE]Related citations
2.
Comparison of atmosphere/aquatic environment concentration ratio of
volatile chlorinated hydrocarbons between temperate regions and
Antarctica.
Zoccolillo L, Amendola L, Insogna S.
Chemosphere. 2009 Sep;76(11):1525-32. Epub 2009 Jun 21.PMID: 19541344
[PubMed - indexed for MEDLINE]Related citations
3.
Volatile chlorinated hydrocarbons in Antarctic superficial snow sampled
during Italian ITASE expeditions.
Zoccolillo L, Amendola L, Cafaro C, Insogna S.
Chemosphere. 2007 May;67(10):1897-903. Epub 2007 Feb 6.PMID: 17287006
[PubMed - indexed for MEDLINE]Related citations
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It then indicates for the first time in this important
International Congress Labiofam 2010 for Natural
Substances:
1) the opportunity to coordinate international studies on
neurotransmitters and neuromodulators of biological significance and newly
discovered (Vittorio Erspamer et all.).
2) to prepare specific laboratories (with Botanical - Medicinal Chemistry and
Pharmacology) for the rapid Pharmacotoxicological classification of the plant
Kingdom to complement the botanical classification of Linnaeus Carl Nilsson. ( We
propose a new method for this basic pharmaco-toxicological study with a savings of
90% of animals and substances).
3) Check the accumulation of environmental pollutants in tissues rich
in
lipids ( brain and gonads)… and their interactions with drugs.
4) Supporting laboratories to study Teratogenesis with other of …
Behavioral Teratogenesis to study of systemic damage to highlight
dangerous behaviour that can jeopardize the survival of offspring.
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For our part we have already reported:
reported
1) The effect of environmental Freons (halogenated Hydrocarbons) on
cardio toxicity.
2)The danger of polychlorinated biphenyls (PCBs) on offspring and
several other environmental pollutants (aldicarb, phthalate,
hexachlorobenzene, foreign body phosphate) with drug interactions.
3) Assumptions for new research into the erosion of glaciers release the
heat produced by solar Freons of low boiling point, with Fallout fallen and
trapped in the ice.
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The ability to study chemical and physical chemical
methods …targeted for recovery of inactivity Freons
fallen
with fallout for the recovery of balance
with climatological study of techniques …to reduce
the emission of greenhouse gases and Global Worming.
Yet was not considered this possibility and there
are no studies on this … to confirm or deny.
Http://solar-center.stanford.edu/sun-on-earth/globwarm.html
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…from CUBA….
thanks for your attention!
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Diapositiva 1 - Informatori.it

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