University Research Laboratories

Transcription

ISTANBUL UNIVERSITY
RESEARCH LABORATORIES
2014
İstanbul University Central Campus
34452 Beyazıt / Fatih-İstanbul
+90 (212) 440 00 00
[email protected]
istanbul.edu.tr
facebook.com/istanbuluniversitesi1453
twitter.com/istanbuledutr
Contents
LABORATORY OF INTERACTIONS BETWEEN SUBSTANCE AND MIND 10
NEUROIMMUNOLOGY and IMMUNOGENETICS LABORATORY 11
LABORATORY of COGNITIVE NEUROSCIENCE 12
BIOPHYSICS LABORATORY 13
LABORATORY of ELECTROENCEPHALOGRAPHY 14
GENETIC RESEARCH LABORATORY 15
HISTOLOGY and EMBRYOLOGY RESEARCH LABORATORIES 16
LABORATORY of CHILD HEALTH and DISEASES, and NUTRITION METABOLISM 17
LABORATORY of NEUROPSCHOLOGY 18
MICROBIOLOGY RESEARCH LABORATORIES 19
PEDIATRIC ENDOCRINOLOGY RESEARCH LABORATORY 20
LABORATORY of MEDICAL BIOLOGY 21
LABORATORY of BRAIN and NEURODEGENERATIVE/NEUROGENETIC DISEASES 22
CENTER for HEARING and SPEECH DISORDERS / LABORATORY of AUDIOLOGY 23
SLEEP and WAKE DISORDERS UNIT 24
LABORATORY of PEDIATRIC GENETICS 25
LABORATORY of MOLECULAR GENETICS 26
ANALYTICAL CHEMISTRY RESEARCH LABORATORY 27
PHARMACOGNOSY RESEARCH LABORATORY 28
PHARMACOLOGY RESEARCH LABORATORY 29
PHARMACEUTICAL TECHNOLOGY RESEARCH LABORATORY 30
PHARMACEUTICAL TOXICOLOGY RESEARCH LABORATORY 31
ISTE (HERBARIUM) 32
LABORATORY of ANDROLOGY 33
LABORATORY of DNA ANALYSIS 34
FOSSIL DNA LABORATORY 35
FOOD SCIENCE LABORATORIES 36
CELL CULTURE LABORATORY 37
IN VITRO FERTILIZATION and EMBRYO TRANSFER LABORATORY 38
CARCASS and MEAT QUALITY LABORATORY 39
OSTEOARCHAEOLOGY LABORATORY 40
VIROLOGY RESEARCH LABORATORY 41
FLOW CYTOMETRY LABORATORY 42
RARE DISEASES RESEARCH LABORATORY 43
MOLECULAR HEMATOLOGY RESEARCH LABORATORY 44
TUBERCULOSIS MOLECULAR EPIDEMIOLOGY LABORATORY 45
LABORATORY of TISSUE CULTURE and PROTEOMICS 46
LABORATORY of NEUROIMMUNOLOGY 47
LABORATORY for PRODUCTION, PURIFICATION and INVESTIGATION of EXPERIMENTAL ANIMALS 48
MOLECULAR METABOLIC RESEARCH LABORATORY 49
ISOLATION and TRANSPLANTATION of ISLETS of LANGERHANS RESEARCH LABORATORY 50
HEMATOPOIETIC and STEM CELL LABORATORY 51
HULUSİ BEHÇET LIFE SCIENCES RESEARCH LABORATORY 52
OBSERVATORY IST60 TELESCOPE 56
SOLAR OBSERVATORY 57
CELL and TISSUE CULTURE LABORATORY 58
MOLECULAR CELL BIOLOGY RESEARCH LABORATORY 59
BIOCHEMISTRY RESEARCH LABORATORY 60
PRIMARY-STEM CELL and CANCER RESEARCH LABORATORY 61
RADIOECOLOGY LABORATORY 62
MOLECULAR CANCER BIOLOGY LABORATORY 63
IMMUNOHISTOCHEMISTRY RESEARCH LABORATORY 64
PHYSIOLOGY RESEARCH LABORATORY 65
MOLECULAR RADIOBIOLOGY and BIOMOLECULAR TECHNOLOGY RESEARCH LABORATORY 66
PLANT BIOTECHNOLOGY and GENETICALLY MODIFIED ORGANISMS LABORATORY 67
ENVIRONMENTAL and INSTRUMENTAL ANALYSIS LABORATORY 68
FUNDAMENTAL and INDUSTRIAL MICROBIOLOGY RESEARCH LABORATORY 69
MOLECULAR RADIOBIOLOGY and PLANT BIOTECHNOLOGY RESEARCH LABORATORY 70
PLANKTON CULTURE LABORATORY 71
ISTF (HERBARIUM) 72
NANO and OPTOELECTRONIC RESEARCH LABORATORY 73
ADVANCED LITHOGRAPHIC METHODS LABORATORY 74
HIGH MAGNETIC FIELD and LOW TEMPERATURE LABORATORY 75
MOLECULAR SPECTROSCOPY LABORATORY 76
LASER SPECTROSCOPY LABORATORY 77
DIELECTRIC SPECTROSCOPY LABORATORY 78
NUCLEAR PHYSICS RESEARCH LABORATORY 79
ANCIENT DNA RESEARCH LABORATORY 80
PLANT BIOTECHNOLOGY LABORATORY 81
PROTEOMICS LABORATORY 82
MOLECULAR DIAGNOSIS in HUMAN DISEASES LABORATORY 83
PLANT GENOMIC RESEARCH LABORATORY 84
BIOINFORMATICS LABORATORY 85
GENETICALLY MODIFIED ORGANISMS LABORATORY 86
PLANT PATHOLOGY LABORATORY 87
PLANT SECONDARY METABOLISM ENGINEERING LABORATORY 88
YEAST GENETICS,TECHNOLOGY and GENOMIC RESEARCH LABORATORY 89
WASTE TECHNOLOGY RESEARCH LABORATORY 90
ORGANIC CHEMISTRY RESEARCH LABORATORY 91
FOOD ANTIOXIDANTS MEASUREMENT APPLICATION and RESEARCH CENTER 92
BIOCHEMISTRY RESEARCH LABORATORY 93
PROCESS and REACTOR DESIGN RESEARCH LABORATORY 94
GEOCHRONOLOGICAL SAMPLE PREPARATION and MINERAL SEPARATION LABORATORY 95
SOIL SCIENCE (AGROLOGY) and ECOLOGY LABORATORY 96
LABORATORY and THERMAL ANALYSIS LABORATORY 97
PROF. DR. A. YILMAZ BOZKURT WOODEN MATERIALS COMBUSTION TEST and ANALYSIS LABORATORY 98
ANNUAL RING RESEARCHES and WOOD ANATOMY LABORATORY 99
100
PROF. DR. A. YILMAZ BOZKURT WOOD ANATOMY LABORATORY FORESTRY PRODUCTS CHEMISTRY and TECHNOLOGY RESEARCH LABORATORY and CELLULOSE, PAPER and CARDBOARD ANALYSIS LABORATORY 101
BASIN MANAGEMENT LABORATORY 102
INSTRUMENTAL ANALYSIS LABORATORY 103
ECOTOXICOLOGY and CYANOTOXIN LABORATORY 104
TECHNOLOGY
TRANSFER
APPLICATION
AND
RESEARCH
CENTER
CENTRAL RESEARCH LABORATORY (MERLAB) 105
PRODUCTION and POST-PRODUCTION LABORATORY 108
PREHISTORY LABORATORY 109
SHIP CONSERVATION and RECONSTRUCTION LABORATORY 110
PREFACE
İstanbul University is the first university in Turkey and among the first ten universities founded in
Europe, directing the society in areas of health, social sciences, natural science and engineering as
well as culture and art throughout its 561-year history. It is the biggest and the most established
university in Turkey, running 767 diploma programs, with its 20 Faculties, 17 Institutes, 3 Colleges,
1 Conservatoire, 7 Vocational Schools, 41 Application and Research Centers, and 3 Departments. It
has a unique training and education potential with its approximately 18,000 graduates.
The objectives of İstanbul University, among world’s top 500 universities (ARWU ranking) for the
past eight years, for the near future are to be among the world’s top 100 universities and maintain
its greatest role in shaping our past/history since 1453 as a “Bridge of Science from the Past into the
Future”.
Istanbul University has the highest number of publications in Turkey, the number of publications
per faculty member increases approximately by 5% each year. It was the serious support attempts
for improving the research facilities of scientists at the international level and for strengthening their
motivation that led to the attainment of this success. What plays a key role in the progress of nations
in the scientific arena is the support given to fundamental scientific research. However, in a globalized
world, research that benefits the society is the only way to achieve sustainable development, welfare the
whole society enjoys, and a future for a world where we can live. The achievement of this objective is
through collaboration of all relevant institute and institutions in areas of research on applied sciences,
without neglecting fundamental scientific research.
In the last five years, İstanbul University has recognized it as its primary objective to carry its research
capacity beyond scientific publications and transform it into new technology and products offering
solutions to the problems of our country, region and world society. Our mission is to produce
sustainable solutions to the problems in the fields of environment, energy sources, social area, health
and culture by research relevant for the society, on the other hand, our vision is to achieve this
objective through regional and academic cooperation and in ten years to carry this process to a level
that will draw attention of the international academic community.
The aim, in preparing the Catalogue of Research Laboratories at İstanbul University, is to enhance our
collaboration with our national and international partners in the fields of health, science, engineering,
and social sciences by presenting our university’s research inventory and facilities for research to
universities, state institutions, private sector establishments, and the public.
We present our research inventory as well as vast opportunities of our laboratories to the attention
of universities, state institutions, private sector entities and society through our catalogue, The
Catalogue of Research Laboratories of İstanbul University, in order to increase our cooperation with
our stakeholders in the fields of health, science, engineering and social sciences. Prof. Dr. Yunus SÖYLET
RECTOR
HEALTH SCIENCES
RESEARCH
LABORATORIES
ISTANBUL FACULTY of MEDICINE
LABORATORY OF INTERACTIONS BETWEEN SUBSTANCE AND MIND
R
10
esearch on impact of modulated transcranial electrical stimulation on assertiveness, studies on
measurement of thresholds of sensation and pain by electrical stimulation,
investigation of impact of transcranial
electrical stimulation on sensation-pain
threshold and sympathetic system, follow-up using neuromonitarization during brain and nervous system surgeries and comparative electrophysiology
studies in invertebrates are conducted,
and design and construction of devices
as well as development of measuring
techniques for these experimental studies continue.
Research Infrastructure of the Laboratory
Modulated transcranial electrical stimulation system,
EEG-Neurofeedback system, Visual stimulation Potential/Electroretinography System (8-channel polygraph, Analog/digital converters, Visual stimulus
presentation systems).
Collaborations and Projects
The laboratory took part in the project titled “Electrical Neuronal Oscillations and Cognition” within
the scope of the COST program by European Union.
A joint project has been conducted with Macedonian
Academy of Sciences on EEG-Neurofeedback within
the scope of TÜBİTAK’s (Scientific and Technological Research Council of Turkey) Macedonia-Turkey
bilateral research support.
Laboratory Supervisor and Contact Information
Prof. Dr. Sacit Karamürsel
+90 212 4142000 - 32507
[email protected]
NEUROIMMUNOLOGY and IMMUNOGENETICS LABORATORY
A
mong autoimmune diseases, immunologic mechanisms of nervous system diseases are predominantly investigated. Firstly, biological
materials of multiple sclerosis, myasthenia gravis and other related disease
groups are stored as in a data bank,
evaluated and developed as a multidisciplinary cooperation environment. Research is conducted by evaluation of
cellular immune response and genetic
examinations.
Laminar flow cabinet, CO2 incubator, Inverted microscope, Fluorescent microscope, ELISA reading
device, Centrifuge, Thermal cycler, Real time thermal cycler (Light thermal cycler), Nanodrop, Horizontal electrophoresis equipment, Gel imaging and
documentation device.
We run collaborative studies with Heidelberg University (Germany), Mannheim University (Germany) and Petras University (Greece).
Prof. Dr. Güher Saruhan
Direskeneli
+90 212 4142000 - 32716
[email protected]
11
LABORATORY of COGNITIVE NEUROSCIENCE
B
12
rain structures and mechanisms
activated during such cognitive
processes as perception, attention, memory and language in human
beings by methods of Electroencephalogram (EEG), Event Related Brain Potentials (ERPs) and Navigated Transcranial Magnetic Stimulation (TMS) are
investigated. Laboratory’s main field of
research is integration of functional MRI
(fMRI) or TMS methods with EEG and
ERP measurements by using TMS and
Magnetic Resonance Imaging (MRI)
compatible EEG/ERP systems. Beside
basic brain research, neurobiological
mechanisms of various dementias and
psychiatric diseases, including primarily Alzheimer’s disease and Parkinson’s
disease, as well as effects of cardiovascular factors posing a risk for cognition
are investigated
EEG/ERPs Laboratory (electromagnetic and sound
isolation room, 32 and 64-channel digital EEG amplifier, visual/auditory stimulus presentation systems
and software, EEG/ERPs analysis software), MR and
TMS compatible 32-channel EEG/ERPs System,
Navigated Transcranial Magnetic Stimulation (TMS)
System.
We have collaborations and joint projects with Bremen University (Germany), Munich Ludwig-Maximilian University (Germany), Max Planck Institute
for Human Cognitive And Brain Sciences (Leipzig,
Germany), Berlin School of Mind and Brain (Germany) and Cuban Neuroscience Institute. We also
conduct joint TÜBİTAK (Scientific and Technological Research Council of Turkey) project with Ankara
University and joint İSTKA (İstanbul Development
Agency) project with İstanbul Şehir University (Turkey) and joint research with Boğaziçi University
(Turkey).
Prof. Dr. Tamer Demiralp
+90 212 4142000 - 32288
[email protected]
BIOPHYSICS LABORATORY
I
mportant studies on cell and tissue
cultures, and stem cells have been
performed for many years. It has
played a pioneering role in production
of Hybridoma and monoclonal antibody in our country. Important studies
are performed on purification of proteins, nucleic acids (DNA-RNA (mRNA,
tRNA)) and any organelles from cells
and tissues, cell and tissue-level imaging by molecular methods (immunofluorescence), recombinant protein production by biotechnological methods,
development and purification of polyclonal antibodies, protein-protein/ protein-ligand interactions, intracellular protein trafficking, in vitro protein synthesis,
description of post-translational modifications (ADP-ribosylation, phosphorylation) and eukaryotic and prokaryotic
protein synthesis mechanisms. There
are studies on apoptosis, oxidative
stress, effects of antioxidants on oxidative stress, mitochondrial damage, C++
metabolisms and ion channels, mesen-
chymal stem cell isolation, culture from
tissue and organs, hematopoietic stem
cells and cancer stem cell isolation and
tissue engineering.
Cold room, Hot room, Dark room, Laminar flow
cabinet, CO2 incubator, Inverted microscope, Fluorescence microscope, Thermal cycler, Semi-dry
“Western Blot”, Vertical and horizontal electrophoresis equipment, Lyophilizer, Viscometer, Mixer (vortex), Liquid chromatography purification system,
Fluorescence spectrophotometer, UV-Vis spectrophotometer, Transilluminator, Electrophoresis tank.
We conduct collaborative studies with MD Anderson Cancer Research Center (USA) and Semmelweis
University (Hungary).
Prof. Dr. Işıl Albeniz
Prof.Dr. Muhammet Bektaş
+90 212 4142000 - 32483
[email protected]
+90 212 4142000 - 32487
[email protected]
13
LABORATORY of ELECTROENCEPHALOGRAPHY
R
14
outine and urgent EEG recording
for diagnosis and differential diagnosis of neurological diseases are
performed. Hyperventilation and photic
stimulation are performed for each patient. Polysomnography and other reflex triggers are used when required.
Both short-term and long-term Video-EEG stimulant recordings are used
for diagnosis of pseudoseizures and seizure types. Moreover, 24-hour and continuous preoperative monitorization for
epilepsy surgery is performed. It is used
as a supportive method for such developing and internal diseases as psychiatric disorders and encephalography. Other than diagnostic recordings, we also
conduct scientific projects for research
purposes.
EEG, Video-EEG device and short-term and longterm continuous Video-EEG.
Projects and studies are conducted with 31 centers
primarily including Germany, Italy and France within the frame of Epicure 6th Framework European Union Integrated Project as well as with Munich Ludwig
Maximilian University (Germany), Genoa University (Italy) on genetic epilepsies with the project titled
Reflex seizures in different epilepsies, and lastly with Italy and the Netherlands on photosensitive epilepsies
within the frame of Marie-Curie Programme.
Prof. Dr. Betül Baykal
+90 212 41420000 - 32598
[email protected]
GENETIC RESEARCH LABORATORY
F
or postnatal and prenatal diagnosis, chromosome obtainment with
short-term and long-term cell cultures, chromosome analysis in different
tissues, FISH and a-CGH analyses, DNA
isolation, Sanger Sequencing, MLPA real
time PCR, enzyme cutting, target mutation in genes, and STR and bioinformatic analyses are performed.
Sterile cabinet, Inverted microscope, Hybridization
device (Hybridizer), Microcentrifuge, Automatic
metaphase finder, FISH microscope with fluorescence attachment, PCR device, Hybridization oven,
magnetic mixer, Microarray scanner, Microarray dryer, Genetic Analyzer (Sequencer), Microcentrifuge,
Vortex, Plate centrifuge, Nanodrop, Digital dry bath,
DNA isolation device.
There are collaborations with Cologne University
(Germany), University of Paris (France), University
of Duisburg Essen (Germany) and Hacettepe University (Turkey) as part of international projects,
CRANIRARE and SBAG-ERA-NET. Joint studies
are carried out with San Diego University on central
nervous system abnormalities and exon sequencing.
Prof. Dr. Seher Başaran
+90 212 4142000 - 32327
[email protected]
15
HISTOLOGY and EMBRYOLOGY RESEARCH LABORATORIES
S
16
upplementary analyses for differential diagnosis of nephropathologic diseases and dermatological bullous diseases, primary ciliary
dyskinesia and some metabolic neurodegenerative diseases as well as etiopathogenesis of spermatozoa-induced
infertility cases and malabsorption syndromes are performed. Preliminary
tests for materials used in practices of
fields such as dentistry and orthopedics, and primary fibroblast culture procedures are performed.
Electron microscope (Jeol 1011), ultramicrotome
(Leica EM-UC7), tissue processor (Leica EM-TP),
Knifemaker (Leica EM-KMR3), EM-Trim 2, laminar flow cabinet, CO2 incubator, inverted phase
contrast microscope, fluorescence microscope and
cyto-counter.
There are research projects conducted with Leibniz
Molecular Pharmacology Institute (Germany), Open
University (UK) and Karolinska Institute (Sweden).
Prof. Dr. Seyhun Solakoğlu
Prof. Dr. Bülent Ahıshalı
Prof. Dr. Leyla Tapul
+90 212 4142000 - 32364
[email protected]
+90 212 4142000 - 32360
+90 212 4142000 - 32366
[email protected]
[email protected]
ISTANBUL FACULTY of MEDICINE LABORATORY of CHILD
HEALTH and DISEASES, and NUTRITION METABOLISM
S
creening, determination of phenylalanine-tyrosine by HPLC and
BH4 challenge tests are performed in Phenylketonuria analysis
unit; screening of biotinidase in serum
and biotinidase activity, Beutler test, reducing substances in the urine, monosaccharide chromatography, oligosaccharide chromatography, metilmalonic
acid determination, nitroprusside test,
dinitrophenylhydrazine test, orotic acid
determination, sodium hydroxide test,
FeCl3 test, ketone determination, and
examinations of amino acids and acyl
carnitine by tandem mass spectrometry, HPLC analysis of quantitative amino
acids and carbohydrate-deficient glycoproteins (CDG), organic acid analyses by
gas chromatography-mass spectrometry and enzyme analyses are performed
in advanced metabolic tests unit.
HPLC systems, amino acid analyzer, tandem mass
spectrometry, gas chromatography-mass spectrometry and fume hood systems.
We conduct collaborative studies with European
Research Network (Switzerland), Center for Disease
Prevention and Control (USA), Screening-Labor
Hannover (Germany), Heidelberg University (Germany), University of Zurich (Switzerland), University of Nijmegen (Amsterdam), University of Manchester (UK) and University of Newcastle (UK).
Prof. Dr. Ümit D. Türkoğlu
Prof. Dr. Gülden Gökçay
+90 212 4142000 - 33202
[email protected]
+90 212 4142000 - 31439
[email protected]
17
LABORATORY of NEUROPSCHOLOGY
I
t is the first neuropsychology laboratory of Turkey, where neuropsychological evaluation and aphasia evaluation
as well as cognitive rehabilitation are
conducted. Evaluations are conducted
by both traditional neuropsychological
batteries and computerized tests.
CANTAB and computerized Stroop WCST tests.
We have collaborations with Northwestern University (USA) and Rutgers University (USA).
18
Prof. Dr. Hakan Gürvit
+90 212 4142000 - 32574
[email protected]
MICROBIOLOGY RESEARCH LABORATORIES
I
t comprises laboratory of bacteriology, laboratory of mycology/mycobacteriology, laboratory of parasitology
and laboratories of virology-immunology. Blood culture, sterile body fluids,
cystic fibrosis patient samples and interferon-gamma release test in blood
samples as well as PCR procedures are
performed and Echinococcus granulosus IgG, Entemoeba histolytica IgG are
studied. Autoantibodies are examined
using ELISA, indirect immune fluorescence and immunoblot method, and
immunophenotyping tests and immunodeficiency panel are performed.
Ovens operating at various temperatures (incubators), CO2 oven, Normal and refrigerated centrifuges, Normal water bath and water bath with shaker,
Elisa devices, Fully automated blood culture device,
Fluorescence microscope, Dark field microscope, Automated bacterial identification system, Light cycler
(for molecular tests), Thermal cycler to be used in
PCR tests, Pulsed Field device (for molecular tests),
lyophilizer in culture collection center, Electrophoresis device, Gel imaging system (transilluminator),
Biosafety cabinets and flow cytometry.
We conduct joint projects with Public Health Agency
of Turkey and World Health Organization on infectious diseases and anti-tuberculosis drug resistance.
We submit data about activity of flu to National Reference Laboratory for Influenza, Ministry of Health
and World Health Organization. We collaborate
with University of Cologne (Germany) on diagnosis
of HIV drug resistance.
Prof. Dr. Nezahat Gürler
+90 212 4142000 - 32377
[email protected]
19
PEDIATRIC ENDOCRINOLOGY RESEARCH LABORATORY
B
lood samples and data from patients diagnosed with congenital
hyperinsulinism, neonatal diabetes, obesity, congenital adrenal hyperplasia, thyroid diseases, type 1 diabetes,
MODY, multiple pituitary hormone deficiencies, idiopathic shortness of stature, excess aromatase and early puberty are collected. DNA, RNA, leukocyte
and serum are extracted and studied.
DNA and RNA extraction robot, PCR, Real time
PCR.
We have collaborations with Exeter University (UK)
about congenital hyperinsulinism and neonatal diabetes cases, with Schneider Children’s Medical
Center (Israel) about a genetic analysis in early puberty, with University of Prague (Czech Republic) on
20
a genetic study of multiple hormone deficiency and
joint studies with TÜBİTAK (Scientific and Technological Research Council of Turkey).
Prof. Dr. Firdevs Baş
+90 212 4142000 - 31645
[email protected]
LABORATORY of MEDICAL BIOLOGY
I
t consists of Laboratory of Tissue Typing and Immunogenetics and Laboratories of Serology, Cell Culture, Flow
Cytometry, Molecular Genetics, DNA
Sequence Analysis and Immunogenetics. Low/high-resolution analyses of
HLA tissue groups in patients/donors
preparing for transplantation of solid
organs and bone marrow/stem cells
along with tissue groups considered
to be related with autoimmune diseases are studied. Cross-match tests and
anti-HLA antibody screening and identification tests which can estimate success of transplantation from living/
cadaveric donors to patients are conducted. Pre-transplantation HLA tissue
typing tests and chimerism assay used
in post-transplantation engraftment follow-up are conducted on patients/donors planned to have stem cell transplantation.
CO2 incubator, Inverted microscope, Fluorescence
microscope, Thermal cyclers, Horizontal electrophoresis equipment, DNA sequencer, Flow cytometry
device and luminex device.
It has been recognized as an accredited laboratory
by European Federation for Immunogenetics (EFI).
It has been appointed by both EFI Quality Control
Committee and Scientific Council for Immunology
of Ministry of Health to organize HLA control tests
among HLA laboratories. International projects are
conducted in the field of Transplantation Immunology/Immunogenetics and Ageing.
Prof. Dr. Fatma Savran Oğuz
+90 212 4142000 - 32461
[email protected]
21
CERRAHPAŞA FACULTY of MEDICINE LABORATORY of BRAIN and
NEURODEGENERATIVE/NEUROGENETIC DISEASES
P
22
rimary neuron culture, gene expression analyses, siRNA gene silencing, qrtPCR methods, polymorphism analyses, Protein analyses
with Western Blot, analysis of cytokines,
chemokines and hormones from body
fluids by ELISA method are performed.
Roles of different genes in diseases can
be determined by neurodegenerative
disease models generated using primary neuron culture, and gene silencing methods. The main fields of study
are molecular mechanisms involved in
neurodegeneration and genetic basis
of Alzheimer’s disease and Parkinson’s
disease.
Laminar flow cabinet in Class 100 Room, CO2 incubator, Inverted microscope, Fluorescence microscope, Thermal cycler, Real time thermal cyclers
(Light Cycler 480, Light Cycler Nano), Picodrop,
iBlot for Western Blot, Horizontal and vertical electrophoresis equipment, Gel imaging and documentation device.
We conduct collaborative studies with Rutgers University (USA), University of Angers (France), University of Exeter (UK) and Thessaloniki School of Medicine of Aristotle University (Greece). Currently a
project on discovery of new biomarkers for Alzheimer’s and Parkinson’s diseases, funded by European
Union, is conducted.
Prof. Dr. Selma Yılmazer
+90 212 4143000 - 22032
[email protected]
Assoc. Prof. Dr. Duygu
Gezen-Ak
Assoc. Prof. Dr. Erdinç
Dursun
+90 212 414 2000 - 21627
[email protected]
+90 212 414 2000 - 21627
[email protected]
CERRAHPAŞA FACULTY of MEDICINE CENTER for HEARING and
SPEECH DISORDERS / LABORATORY of AUDIOLOGY
S
uch studies as hearing tests for
neonates, children and adults, diagnosis and therapy programs for
speech-voice and language disorders,
scholastic follow-up of and support for
individuals with hearing loss, prognosis
and rehabilitation of balance disorders,
noise and hearing conservation programs, hearing screening programs for
neonates, preschool and school-aged
children, hearing aid, and implants of
middle ear, inner ear and brain stem are
conducted.
Computerized dynamic posturography, Head impulse, Measurement equipment for cortical auditory evoked potential responses, Multi-frequency immitancemetry, Voice analysis system.
We participate in supporting individuals with hearing loss by the joint project with İstanbul Development Agency. We have projects on development of
an analysis algorithm for dynamic vestibular system, and medical equipment development within
the scope of TÜBİTAK (Scientific and Technological Research Council of Turkey) project conducted
in collaboration with İstanbul Technical University
(Turkey).
Prof. Dr. Ahmet Ataş
+90 212 4143000 - 22686
[email protected]
23
CERRAHPAŞA FACULTY of MEDICINE
SLEEP and WAKE DISORDERS UNIT
D
iagnosis and treatment of sleep
disorders and polysomnographic examinations for preliminary
diagnosis of epilepsy are performed.
It is the only unit in Europe accredited
accordind to criteria set by European
Sleep Research Society and authorized
to deliver training and certification programs for specialists from Europe.
3-channel EEG [F4-M1, C4-M1, O4-M1] for fullnight polysomnography, Two-channel EOG, Superficial EMG of chin, Right/left tibialis anterior, and
body position sensor, Oro-nasal sensor, Nasal pressure sensor, Thoracic and respiratory movements,
ECG, Recording of respiratory sounds, O2 saturation
and synchronous video recording.
24
We conduct a randomized, double-blind study in
which a comparison of BF2.649 (Pitolisant) and
plasebo in two parallel groups in daytime hypersomnia and frequency of weekly cataplexy attacks in narcoleptic patients with cataplexy is made, along with
a device development project for detection of cardio-respiratory events during sleep by a device other
than polysomnography, that is a multi-center study
as part of a European Union project.
Prof. Dr. Derya Karadeniz
+90 212 4143000 - 22151
[email protected]
LABORATORY of PEDIATRIC GENETICS
C
hromosome analysis from blood,
skin, bone marrow and prenatal
samples (fetal blood, amnion fluid and corion villus biopsy) and diagnosis of micro-deletions by fluorescence
in situ hybridization are performed.
diseases conducted jointly with Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Hospital Necker Enfants Malades, France; Department
of Genetics; Research on “cilia” disorders conducted
jointly with Department of Molecular Medicine and
Birth Defects Research Center of University College
London (UCL), England; a study on genetic substructure of Cutis laxa group of disorders jointly conducted with Institut für Medizinische Genetik und
Humangenetik, Charité-Universitätsmedizin Berlin,
Augustenburger Platz 1, Berlin, Germany; Research
Karyotech PSI Karyotype+FISH analysis system, In-
on Noonan group (RASopathies) of disorders joint-
cubator, Microscope, Thermo-Highmeter, Refriger-
ly conducted with Dr. Martin Zenker Institute of
ated centrifuge, CO2 incubator, pH meter, Laminar
Human Genetics, University Hospital Magdeburg
flow cabinet, Hybridization unit, Spectrophotome-
Leipziger, Germany; Research on diseases accompa-
ter, Deep freezer.
nied by osteoporosis conducted jointly with Pediatric
Endocrinology and Metabolic Bone Diseases De-
partment of Pediatrics, Helsinki University Hospital,
We conduct the following projects with following
Finland; arthrogryposis and Cornelia de Lange group
partners: Identification of new genes in different
of diseases conducted jointly with Department of
genetic diseases conducted jointly with Yale Uni-
Molecular and Human Genetics, Baylor College of
versity (England), Department of Neurosurgery,
Medicine, Houston, USA.
Neurogenetics Program; genetic studies of skeletal
Prof. Dr. Beyhan Tüysüz
+90 212 414 3000 - 21495
[email protected]
25
LABORATORY of MOLECULAR GENETICS
B
eside studies and analyses regarding diagnosis and treatment planning of many diseases, including
routine studies on genetics of single
gene disorders, infertility tests and genetics of cancer and leukemia, projects
pertaining to research-development
studies are conducted in laboratory of
molecular genetics and cell culture.
37°C incubator, Light cycler 480 real time PCR
device, Thermal cycler, Electrophoresis units, Gel
imaging device, Centrifuges (refrigerated, vacuum),
DNA isolation device, -20°C and -80°C cooling
chambers, Microwave, Oven, ABI 3500 sequence
analysis device, Light cycler 2.0 Real Time device,
Pyro sequence (for specific sequencing), Rotor Gene
(real time device) and Laminar Flow cabinet.
26
Ongoing research & development projects supported
by TÜBİTAK (Scientific and Technological Research
Council of Turkey) are investigation of MiRNAs in
human laryngeal cancer, determination of tongue
cancer-specific miRNAs and investigation of MiRNAs in patients with delirium.
Prof. Dr. Mustafa Özen
+90 212 4143000 - 21468
[email protected]
FACULTY of PHARMACY
ANALYTICAL CHEMISTRY RESEARCH LABORATORY
D
evelopment and validation of
spectrometric, high performance
liquid chromatographic and gas
chromatographic methods for drug
analyses constituting the basis of research and development, quality control studies, qualitative and quantitative
analyses of drug substances and impurities in pharmaceutical preparations
and biological materials are conducted
and method validation as well as pharmacopoeia analyses are performed in
conformity with international guidelines.
Spectrophotometer, Spectrofluorimetry, Flow injection system, High performance liquid chromatography (UV, diode-array, fluorescence and electrometric
detection, online SPE-LC, UPLC), Gas chromatography (with flame ionization and mass spectrometric
detection).
Studies are conducted with Istanbul Technical University (Turkey), Yildiz Technical University (Turkey), Bezmialem Foundation University (Turkey),
Yeditepe University (Turkey), Anadolu University
(Turkey), Pamukkale University (Turkey), Namik
Kemal University (Turkey), Dicle University (Turkey), Batman University (Turkey), Munich University (Germany), Barcelona University (Spain), Cairo
University (Egypt) and Free University of Brussels
(Belgium). These studies are based on development
and validation of new analytical techniques and
methods.
Prof. Dr. Serap Sağlık Aslan
+90 212 4400000 - 13588
[email protected]
27
FACULTY of PHARMACY
PHARMACOGNOSY RESEARCH LABORATORY
I
solation and structural determination of compounds isolated from medicinal plants are performed by using
chromatographic methods and conducting spectral analyses. Moreover,
various biological activities of plant extracts and isolated compounds are investigated.
High performance liquid chromatography (with diode-array and fluorescence detection), Medium pressure liquid chromatography, Flash chromatography,
chromatotron, Vacuum liquid chromatography, Vacuum speed concentrator, Lyophilizer, Vacuum oven.
Collaborative studies are done with Anadolu University (Turkey), Marmara University (Turkey), Uni-
28
versity of Saarland (Germany), University of Paris
(France), University of Mostaganem (Algeria), Free
University of Berlin (Germany) and Institute of Leibniz (Germany). Studies have been conducted on
isolation of active compounds from plant resources
and demonstration of activity.
Prof. Dr. Afife Mat
+90 212 4400000 - 13400
[email protected]
FACULTY of PHARMACY
PHARMACOLOGY RESEARCH LABORATORY
P
harmacology of gastrointestinal (i.e. experimental ulcer model)
and central nervous systems (experimental and genetic epileptic models), pharmacological studies [examination of impacts of P-glycoprotein and
transporter proteins of ABC gene family on pharmacokinetics of medicines
and determination of levels of medicines in plasma and other body fluids
by high pressure liquid chromatography
(HPLC)] are performed in addition to examination of activities of medicines and
active substances of plant/synthetic
origin in such areas as pharmacology
of cardiovascular system (experimental hypertension, diabetic and glaucoma models as well as isolated vascular
and cardiac preparations obtained from
test animals and humans such as aorta, mesenteric artery, renal artery, retinal
artery, basilar artery, human intra-mammary artery, human saphenous vein,
human radial artery and heart etc.),.
Organ bath system, Myograph system, High performance liquid chromatography, Solid and liquid
phase extraction systems (with UV and fluorescence
detection), Angendorff system, ELISA device and
telemetry system.
Studies conducted with Ege University (Turkey), Institute for Biological Rhythms and Cancer of University of Paris XI (France), and University of Paris
Nord, Inserm UMR-S698 (France). Studies are in
the fields of pharmacology of cardiovascular system
and pharmacokinetics.
Prof. Dr. Sönmez Uydeş Doğan
+90 212 4400000 - 13418
[email protected]
29
FACULTY of PHARMACY
PHARMACEUTICAL TECHNOLOGY RESEARCH LABORATORY
D
30
rug formulation studies (solid
dosage forms, disperse systems,
topical and transdermal drug delivery systems, new drug delivery systems (microspheres, vesicular delivery
systems, solid lipid nanoparticles, and
polymeric micelles), bio-adhesive systems, ocular, pulmonary, nasal and buccal drug delivery systems and radiopharmaceuticals), drug stability studies
and targeted (brain, liver, lungs, bone
and colon) drug delivery system studies
are carried out.
ameter.
Collaborative studies are conducted with Marmara
University (Turkey), London School of Pharmacy
(England), University of Bath (England), Cardiff
University (England), Trinity College (University of Dublin) (Ireland), University of Pittsburgh
(USA) and Innsbruck Medical University (Austria).
Lung-targeted drug delivery, transdermal and dermal, pharmaceutical cell culture and radiopharmacy studies have been carried out. Studies regarding
development of anti-cancer medicine as part of Euronanomed project have been completed. SANTEZ
project conducted as part of a cooperation between
Texture analyzer, Dissolution system, Nano-zetasizer,
university and industry, and TÜBİTAK (Scientific
and Technological Research Council of Turkey) projects continue.
Lyophilizer, High performance liquid chromatography (with diode-array and fluorescence detection),
Franz diffusion cell system, ATR-FTIR spectrometer, Cell culture laboratory equipment, Tewameter,
Corneometer, Skin pH-meter, Sebumeter and mexLaboratory Supervisor and Contact Information
Prof. Dr. Yıldız Özsoy Erginer
+90 212 4400000 - 13498
[email protected]
FACULTY of PHARMACY
PHARMACEUTICAL TOXICOLOGY RESEARCH LABORATORY
I
t consists of Molecular & Analytical
Toxicology, Genotoxicity and Cell Culture Laboratories, and Pharmacogenetic Diagnosis Unit. Investigation of
mechanisms that play a role in toxicological effects of xenobiotics (especially genetic and epigenetic mechanism
studies, in vitro and in vivo detection
of DNA and chromosomal damages,
and oxidative damages, DNA methylation, histone modifications and changes in gene and protein expressions) is
performed. Minimum toxicity and maximum therapeutic effect, targeted delivery of especially chronically administered drugs are intended to achieve a
narrow therapeutic index in “Individualized Medicine” and determination of differences of gene and proteins involving
in metabolism are carried out by coordinated studies with clinical units.
Real time thermal cycler (RT-PCR), Thermal cyclers, Electrophoresis and gel visualization systems,
Microscope with fluorescence attachment, High performance liquid chromatography (with diode-array
and fluorescence detection), Cell culture laboratory
equipment.
We work in collaboration with Sabancı University
(Turkey), and Boğaziçi University (Turkey), Newcastle University (England), University of Würzburg
(Germany) and University of Birmingham (England). Two TÜBİTAK (Scientific and Technological Research Council of Turkey) projects have been
carried out.
Prof. Dr. Buket Alpertunga
+90 212 4400000 - 13565
[email protected]
31
FACULTY of PHARMACY
ISTE (HERBARIUM)
I
32
STE contains a significant collection of plant species comprising 70%
of all plants in Turkey, including primarily medicinal plants, rich in terms
of plant samples from Istanbul and
Thrace (90%), some of the medically
most important plant species (such as
Allium, Arum, Asphodeline, Cirsium, Colchicum, Crocus, Cyclamen, Euphorbia,
Ferulago, Helichrysum, Hypericum, Iris,
Papaver, Rosa, Salvia, Sedum, and Tulipa) as well as more than 115,000 plant
samples. All plant samples are scanned
and input is stored in a database called
“ISTE Information System” and is available on ISTE website for those interested. ISTE contains all endemic monotypic species in flora of Turkey.
It contains photographs of more than 150 types of
samples and more than 100 photographs of typus.
Stereo microscope fitted with a drawing tube and
that transmit images into digital media, Chromosome analysis system, Ice microtome (cryostat).
We work in collaboration with Anadolu University (Turkey) and Cumhuriyet University (Turkey).
Studies for identification and preservation of flora
of Turkey have been conducted in these collaborations. European Union and IUCN projects regarding
conservation of biodiversity and its sustainable development are performed. It represents Turkey in programs and databases such as “Euro-Med Plant Base”
and “Atlas Florae Europaeae”. Istanbul Development
Agency project on honey plants and KAMAG projects supported by TÜBİTAK (Scientific and Technological Research Council of Turkey) on identification of geophytes of Turkey and chromosomes are
carried out.
Prof. Dr. Emine Akalın
+90 212 4400000 - 13578
[email protected]
FACULTY of VETERINARY MEDICINE
LABORATORY of ANDROLOGY
S
tudies are conducted on freezing
and long-term preservation of semen of farm animals and pets,
development of semen freezing techniques as well as discovery of new additives and methods for cryopreservation. Artificial vaginal mucus and a new
measurement technique have been developed for determination of potential
fertility. Advanced analyses, as well as
determination and preservation studies of potential fertility are carried out
on frozen semen. This laboratory also
functions as a “Reference Laboratory”
of the Ministry of Agriculture and prepares reports required for import authorizations of imported semen.
A study involving the freezing of semen samples from
five sheep breeds and delivery thereof to National
Domestic Animal Gene Bank for establishment of
a database was conducted in collaboration with the
Ministry of Agriculture, TÜBİTAK-MAM GMBE,
Ankara University (Turkey), Uludağ University (Turkey), Selçuk University and Middle East Technical
University (Turkey). A study for freezing ram semen
has been carried out in collaboration with the Ministry of Agriculture, TÜBİTAK-MAM GMBE, Uludağ University, and University of Missouri (USA)
and an appropriate freezing protocol has been developed in order to develop a DNA Analysis Laboratory
technique and a freezing technique that can be used
in TAGEM (General Directorate of Agricultural Re-
search) institutes.
Semen analysis equipment, Phase contrast microscope (magnification x40 – x10000), Microscope
with fluorescence attachment (magnification x40 x1000), Semen freezing system.
Prof. Dr. Kemal Ak
Prof. Dr. Alper Baran
+90 212 4737070 - 17257
[email protected]
+90 212 4737070 - 17261
[email protected]
33
LABORATORY of DNA ANALYSIS
G
enomic and mitochondrial DNA
analyses concerning pets have
been carried out. Gene polymorphisms of pets in particular (Prion, GH,
Prolactin, IGF-1, OPN, PIT-1, FASN, SCD,
LEP, Milk Protein Genes, agouti genes
etc.) are demonstrated both by the sequence analysis method and the PCRRFLP analysis method. Besides, mitochondrial DNA analyses are performed.
Thermal cyclers, UV imaging device, Mini and midi
Submarine electrophoresis, Vertical electrophoresis,
Refrigerated centrifuge and mini centrifuge.
We conduct joint studies with European Science
Foundation (Austria) on genomic and mitochondrial
DNA analyses. We have collaboration protocols with
Yıldız Technical University (Turkey) and Ege Univer-
34
sity (Turkey).
Prof. Dr. Kemal Özdem Öztabak
+90 212 4737070 - 17126
[email protected]
FOSSIL DNA LABORATORY
D
NA isolation is conducted on
bones of pets and wild animals
unearthed in archaeological excavations and their mitochondrial DNAs
are compared with those of living animals.
Laminar flow cabinet, UV sterilizer, Electrophoresis,
Thermal Cyclers.
Goat bones unearthed in excavations of Van-Yoncatepe castle were studied. We conduct research on
Ancient DNA Extraction Methods in collaboration
with University of York (UK).
35
Prof. Dr. Kemal Özdem Öztabak
+90 212 4737070 - 17126
[email protected]
FOOD SCIENCE LABORATORIES
F
36
ood Science Laboratories, with
over 30 years of experience, conducts national and international
studies in the fields of food science and
water hygiene in cooperation with industry and public sector, in an enclosed
area of approximately 2000 m2. It comprises Food Microbiology Laboratory, Food Chemistry Laboratory, Food
Technology Laboratory, Molecular Analysis Laboratories, and Pilot Research
Slaughterhouse. Additionally, laboratories support industry and public sector
for routine analyses.
Various joint studies on food safety, food security and
food authenticity are conducted in cooperation with
many national and international institutions, such as
Ankara University (Turkey), Uludağ University (Turkey), Adnan Menderes University (Turkey), Selçuk
University (Turkey), TÜBİTAK MAM (Marmara
Research Center), Pendik Veterinary Research Institute of Turkish Ministry of Food, Agriculture and
Livestock, European Union Joint Research Centre,
University of Vienna (Austria), Ludwig-Maximilians
University Munich (Germany), University of Bristol
(England), University of Surrey (England), University of Thessaloniki (Greece), Joseph Fourier University (France), University of Georgia (USA), Texas
A&M University (USA), United States Department
of Agriculture, Texas Agricultural Research Center
(USA).
Cooled and regular centrifuges, magnetic and regular
mixers and shakers, Ultra centrifuge, Spectrophotometer, Evaporator, PCR thermal cyclers, Gel electrophoresis, Gel screening, Laminar flows, Bio-safety
cabinets, Homogenizers, ELISA reader, Automated
milk analyzer, MAP, vacuum and stretch packaging machines, Gas analyzer, Texture analyzer and
its apparatus, chromometer, Incubators, Stomacher,
Blender and smashers, Aw-meter, Soxhlet, Trichinoscope, analysis equipment and kits for food microbiology and food technology.
Prof. Dr. Gürhan Çiftcioglu
+90 212 4737070 - 17222
[email protected]
CELL CULTURE LABORATORY
P
harmacological effects of new
drug molecules or candidate drug
molecules on healthy and cancer
cell progenies are analyzed by molecular techniques for elucidation of mechanisms of action thereof. Moreover, we
conduct molecular studies on determination of pharmacological effects of
various plant extracts, which are raw
materials of drugs. Potential genotoxic
effects of compounds are determined
using various genotoxicity tests (comet
and micronucleus test).
We conduct research as part of TÜBİTAK (Scientific
and Technological Research Council of Turkey) and
COST projects. Studies such as molecular investigation of pharmacological effects of drug substances
on cancer cells, determination of pharmacological
properties and biological activities of plant extracts,
investigation of effect of a commonly used veterinary
antibiotic on anaerobic digestion systems producing
biogas from animal manure and determination of
outcome thereof in receiver environment, increasing
biomethane productivity in anaerobic digesters by
Multi-mode Reader System for Absorbance, Fluores-
using specific rumen bacteria and hydrolysis enzymes
are performed in collaboration with different departments of various universities.
cence and luminescence measurements, Cell counter, CO2 incubator, Western Blot, Thermal Cycler,
Inverted Microscope, Fluorescence microscope, Lyophilizer, Spectrophotometer with Dual Beam and
Xenon Lamp, Class II Biological safety Cabinet,
protein detection device, Vertical and horizontal gel
electrophoresis, Ultrapure Water system.
Prof. Dr. Tülay Bakırel
+90 212 4737070 - 17141
[email protected]
37
IN VITRO FERTILIZATION and EMBRYO TRANSFER LABORATORY
I
38
n 2000, lambs, the first farm animals
to be produced by in vitro fertilization
in Turkey, were born in this laboratory, in 2007 Turkey’s first animals were
cloned, in 2009 the first grey bull was
cloned, and in 2010 the first grey female calves were cloned, in 2013 the
first lambs were born by intracytoplasmic sperm injection method, the first
transgenic rabbits and the first transgenic lambs were born. Development
of estrus synchronization techniques
in farm animals, oocyte yield in farm
animals, pets and laboratory animals,
improvement of in vitro culture environments, freezing and long-term preservation of oocytes and embryos, improvement of cloning techniques in cats
and sheep, embryonic stem cells, development of gene delivery systems to
produce transgenic animals, ICSI transgenesis, sperm-mediated transgenesis and pronuclear gene injection are intensely studied.
Inverted microscope with fluorescence attachment,
Micromanipulation system, Piezo microinjection,
Micromanipulation system, Cell electrofusion system and oxygen and CO2 incubators.
Embryos of five sheep breeds were frozen and delivered to National Domestic Animal Gene Bank, by
which farm animal species specific to Anatolia are
to be protected, that was established in cooperation
with the Ministry of Agriculture, TÜBİTAK-MAM
GMBE, Ankara University (Turkey), Uludağ University (Turkey), Selçuk University (Turkey) and Middle
East Technical University (Turkey). Embryo production studies by ICSI method, using lyophilized semen
and mouse embryonic stem cell transfection studies
continue in collaboration with Uludağ University
(Turkey) and Fatih University (Turkey), respectively.
Collaborations with University of Hawaii and mouse
embryonic stem cell transfection studies jointly conducted with Fatih University continue. Research was
conducted on control of reproduction and biology
of reproduction, and a new method was developed
for estrus synchronization as a consequence of the
projects conducted. Moreover, a vaginal tablet which
may be used for estrus synchronization was developed and patent applications were made to TPI
(Turkish Patent Institute) and EPO.
Prof. Dr. Serhat Pabuccuoğlu
Prof. Dr. Sema Birler
+90 212 4737070 -17258
[email protected]
+90 212 4737070 - 17259
[email protected]
CARCASS and MEAT QUALITY LABORATORY
C
haracteristics of meat such as
color, tenderness and juiciness
are analyzed by reliable scientific
methods. Meat samples are evaluated
in terms of parameters such as texture
analysis, meat and carcass color analysis, passive water loss, water-holding
capacity, measurement of loss on cooking, and meat taste panel. Furthermore,
studies on determination of quality of
carcass (measurement of carcass size,
determination of muscle area and composition (meat, bone, fat ratio)) are performed.
Texture analyzer and a Warner-Blatzler blade compatible with this device, Chromometer.
Joint studies were carried out by researchers from
Uludağ University (Turkey), Kafkas University (Turkey), Çanakkale Onsekiz Mart University (Turkey),
Mustafa Kemal University (Turkey), and Ondokuz
Mayıs University (Turkey) to determine carcass and
meat quality traits of farm animals of various species in different production systems used in Turkey,
which were supported by TÜBİTAK (Scientific and
Technological Research Council of Turkey) and the
Ministry of Agriculture. Joint studies were performed
with European Federation of Zootechny (Italy) on
high quality meat production.
Prof. Dr. Bülent Ekiz
Dr. Hülya Yalçıntan
+90 212 4737070 - 17230
[email protected]
+90 212 4737070 - 17133
[email protected]
39
OSTEOARCHAEOLOGY LABORATORY
A
rchaeological materials collected from archaeological excavations are analyzed. Identification
of species, modifications, and pathologies and all traces and remains are analyzed and answers are sought for many
questions including, in particular, those
about human-animal relationships in
communities in the past.
Reference collections.
National and international collaborations are established through proposal of scientific projects on
analysis of materials from Subway and Marmaray
(Yenikapı) excavation, and excavation studies of
Kuşadası-Kadıkalesi (Anaia), Amasya-Oluz Mound,
Van Castle Mound and Yoros Castle. Excavation
40
analyses are performed in cooperation with Presidencies of Excavations and Archaeology Museums.
Within the frame of cooperation with University of
Wroclaw (Poland), University of Trakia (Bulgaria)
and Academy of Natural Sciences (Belgium), not
only projects are carried out, but also joint studies
are conducted with foreign scientists.
Prof. Dr. Vedat Onar
+90 212 4737070 - 17225
[email protected]
VIROLOGY RESEARCH LABORATORY
S
tudies of serological diagnosis of
viral diseases and viral zoonoses
in animals, virus production methods, and molecular diagnosis and gene
analysis are conducted. Moreover, studies on methods of protection from, and
control of and eradication of viral diseases are performed.
We conduct collaborative studies with Kansas State
College of Veterinary Medicine (USA), Liverpool
School of Veterinary Medicine (UK), Bristol School
of Veterinary Medicine (UK), Ohio College of Veterinary Medicine (USA), Madrid Faculty of Veterinary Medicine (Spain), Hungarian Medical School
(Hungary), Bari Faculty of Veterinary Medicine (Italy), Athens Faculty of Veterinary Medicine (Greece),
Nippon Institute of Technology (Japan), University
of Queensland (Australia), Veterinary Institute of
Wageningen (Netherlands), Friedrich Loeffler Institute (Germany). Our projects on detection of Hepatitis A and B in environmental samples and water
CO2 incubator, Inverted microscope, Shaking incubator, Egg incubator, Refrigerated and normal microcentrifuges, Ultra-centrifuge, Spectrophotometer,
samples as part of TÜBİTAK (Scientific and Technological Research Council of Turkey) projects and
investigation of infectious bronchitis virus in poultry
as part of COST project still continue.
Real time PCR devices, Gel electrophoresis, Gel imaging device, Bio II safety cabinets, Homogenizers,
Thermoblocks, Western blot, ELISA reader, Lyophlizer.
Prof. Dr. Hüseyin Yılmaz
+90 212 4737070 - 17069
[email protected]
41
INSTITUTE of EXPERIMENTAL MEDICAL RESEARCH
FLOW CYTOMETRY LABORATORY
P
resence and functions of immune
system cells are determined and
proteins presented on the cell
surface or inside the cell and their cell
functions are demonstrated by fluorescent-labelled mono-clonal antibodies,
and specific cell populations can be purified.
We have collaboration protocols with University of
Giessen (Germany), Allergy and Asthma Research
Center (Switzerland), St. Anna Children’s Hospital (Austria), Uludağ University (Turkey), Medipol
University (Turkey), Marmara University (Turkey),
Bezm-i Âlem Foundation University (Turkey), Kocaeli University (Turkey), Ankara University (Turkey), Ege University (Turkey), Selçuk University
(Turkey), and Yüzüncüyıl University (Turkey).
42
Mechanisms involved in immunopathogenesis of
Behçet’s disease, Multiple Sclerosis, and allergy and
asthma are investigated as part of TÜBİTAK (Scientific and Technological Research Council of Turkey)
FACSCalibur Flow Cytometry (4 color analysis
projects and projects are conducted on development
of new technologies for treatment of Type 1 Diabetes
as part of the Inten-C project.
of subcellular groups stained by 4 different color
fluorescent-labelled antibodies at the same time),
FACSAria II Flow Cytometry (10 color analysis of
cells at the same time), Refrigerated centrifuge, Laminar flow cabinet.
Prof. Dr. Günnur Deniz
+90 212 4142000 - 33306
[email protected]
RARE DISEASES RESEARCH LABORATORY
R
esearch techniques required for
investigation and diagnosis of rare
diseases and cerebral conditions
such as epilepsy, ataxia etc., including
undiagnosed diseases frequently occurring in Turkey as a consequence of
consanguineous marriages and tradition of having more than one child, are
developed and applied in our laboratory. We study individual cases with multiple congenital anomalies and/or mental retardation conditions by SNP-array
based molecular karyotyping approach.
In familial studies, data obtained from
such new generation techniques as
whole genome methylation and whole
genome exome sequencing based on
SNP genotyping, whole genome linkage
and haplotype analyses are analyzed.
We have currently been constructing a
DNA bank, a rich inventory to be used as
reference for individuals with rare genetic neurological diseases. Rare Diseases
Research Laboratory is Orphanet’s coordinator in Turkey.
454 GS FLX Sequencer, GS Junior System, Confocal
microscope.
A DNA bank was constructed by collecting DNA
samples from epilepsy patients as part of an EU-funded FP6 integrated project on epilepsy (EPICURE)
and clinical characterizations of patients were jointly
conducted by specialist neurologists from İstanbul
Faculty of Medicine and Cerrahpaşa Faculty of Medicine of İstanbul University (Turkey). International
Inten-C project is conducted under Turkish (DETAE (Institute of Experimental Medical Research),
Boğaziçi University and Sabancı University) and
German (Cologne Center for Genomics) partnership, and studies are performed as part of TÜBİTAK
(Scientific and Technological Research Council of
Turkey) projects.
Prof. Dr. Uğur Özbek
+90 212 4142000 - 33312
[email protected]
Assoc. Prof. Dr. Sibel Uğur
İşeri
+90 212 4142000 - 33312
[email protected]
43
MOLECULAR HEMATOLOGY RESEARCH LABORATORY
W
44
e conduct studies on investigation of signaling pathways
involved in the development
of leukemia and genes with a prognostic significance in acute leukemia using
whole genome expression and methylation array analyses and amplicon deep
sequencing applications, as well as frequently occurring primary immune deficiency diseases due to high rates of
consanguineous marriages in Turkey.
It is the first and only center offering diagnostic services for immune deficiency diseases such as SCID, CVID and
XLA in Turkey and conducts gene therapy trials in XLA mouse models. It is also
a member of European Leukemia Network (ELN) and the sole IS-certified reference laboratory in Turkey for detection of BCR/ABL.
454 GS FLX Sequencer, GS Junior system, High security cell culture laboratory and cabinets, Bacteria
culture laboratory, Confocal microscope and fluorescence microscope and microplate luminescence
reader.
We perform studies as part of IRON II and IRON
III projects under European Leukemia Network and
conduct deep sequencing analyses with Roche Life
Sciences. Interdisciplinary projects supported by
TÜBİTAK (Scientific and Technological Research
Council of Turkey) and Turkish Society of Hematology Research Fund are conducted with universities
such as İstanbul Faculty of Medicine (Turkey), Cerrahpaşa Faculty of Medicine (Turkey), Marmara University (Turkey), Hacettepe University (Turkey), Ege
University (Turkey), Kocaeli University (Turkey).
Furthermore, we perform joint projects with Erasmus Faculty of Medicine (The Netherlands), Heidelberg University (Germany) and St Jude Children’s
Research Hospital (USA).
Prof. Dr. Uğur Özbek
+90 212 4142000 - 33312
[email protected]
Assoc. Prof. Dr. Müge
Sayitoğlu
+90 212 4142000 - 33312
[email protected]
TUBERCULOSIS MOLECULAR EPIDEMIOLOGY LABORATORY
W
e conduct studies on detection
of DNA fingerprints of strains
causing tuberculosis in İstanbul and surrounding areas by molecular methods, and determination of infection dynamics of the region along
with research on molecular mycobacteriology. IP 10 levels in whole blood samples stimulated with ESAT 6 and CFP 10
antigens were determined and a IG(P)
RA test identifying latent TB was developed. A new species of mycobacteria,
“Mycobacterium celeriflavum sp. nov”,
has been identified and studies for developing kits for detection of rapid resistance to drugs and identification at
the same time continue. It serves as
the “Top-level Laboratory of İstanbul Anti-tuberculosis Association” upon a protocol signed between İstanbul Anti-tuberculosis Association and Rectorate of
İstanbul University.
Light/fluorescence microscope and capillary electrophoresis and sequence analyzer used in DNA fragment analysis and sequence analysis.
We conduct joint projects on identification of new
species of mycobacteria with San Raffaele Scientific
Institute (Italy), detection of Beijing genotype tuberculosis strains in our country and adaptation thereof
to regional human populations with St. Petersburg
Pasteur Institute (Russia), and genotypic diversity of
Mycobacterium caprae and characteristics of the disease it causes in human beings with Agency for Food
and Health Safety (Austria).
Assoc. Prof. Dr. O. Kaya
Köksalan
+90 212 4142000 - 33345
[email protected]
45
LABORATORY of TISSUE CULTURE and PROTEOMICS
W
46
e conduct various research
projects and protein analysis studies in cytogenetic, biochemical and molecular fields using cell
culture and tissue culture technology.
We examine alterations in gene and protein expression levels, cell life cycle and
signaling pathways occurring in parallel with alterations in cells and tissues in
different cancer types and such various
metabolic disorders as obesity and diabetes, in addition to conducting miRNA
and protein microarray analyses. Moreover, we investigate effects of many different substances on etiology and prognosis of diseases. We conduct studies
to determine contents, elucidate functions and establish structural properties
of proteins in various biological materials.
Fluorescence Microscope, Optical microscope, CO2
incubator, Laminar flow cabinet, Particle counter,
Cell viability measurement device, Fluorometer,
Western Blot device and its equipment.
We conduct national and international collaborative studies with University of De Montfort (UK),
Sabancı University (Turkey), and İstanbul Technical
University (Turkey). In addition, we carry out multiple interdisciplinary projects funded by State Project
Organization, İstanbul Development Agency and
TÜBİTAK. We carry out joint projects with various
organizations and institutions such as BAL-DER
which is active in various industrial fields.
Prof. Dr. Oğuz Öztürk
+90 212 4142000 - 33303
[email protected]
LABORATORY of NEUROIMMUNOLOGY
W
e conduct studies for elucidation of pathogenesis and identification of new biomarkers
for multiple Sclerosis, neuromyelitis optica, autoimmune encephalitis and neuro-Behçet’s diseases using cell culture
and molecular biology methods. Various treatment methods, including mesenchymal stem cell application, are
tried using immunization-based experimental animal model of myasthenia
gravis disease. We examine gene and
protein expression levels in tissue samples from different autoimmune neurological diseases and alterations in survival/apoptotic signaling pathways.
We conduct studies for identification
of new autoantibodies in autoimmune
neurological diseases by primary neuronal culture cells, transfected cells and
protein macro-array methods.
Optical microscope, Laminar flow cabinet, Western
Blot, Immunohistochemistry and ELISA device.
We conduct various collaborative studies such as experimental myasthenia gravis studies with University
of Texas (USA), analysis of intestinal microbiome in
neuro-Behçet’s disease with Baylor College of Medicine (USA) and identification of new autoantibodies in neuromyelitis optica cases with University of
Patras (Greece).
Assoc. Prof. Dr. Erdem Tüzün
+90 212 4142000 - 33356
[email protected]
47
INSTITUTE of EXPERIMENTAL MEDICAL RESEARCH LABORATORY for
PRODUCTION, PURIFICATION and INVESTIGATION of EXPERIMENTAL ANIMALS
W
e conduct various projects in
areas such as housing, care
and production of laboratory animals as well as performance of
investigational trials thereon and providing subsequent post-operative care
thereof.
Individually ventilated cage system, Surgical microscope, Microscope imaging system and recorder,
infusion pump, Pressurized washing machine (90
L capacity), Optical microscopes, Blood collection
containers (for rats, mice, and rabbits), Isolator.
We conduct projects in cooperation with Leibniz Institute for Molecular Pharmacology (Germany) and
48
Karolinska Institute (Switzerland) and participate
in a COST project on gene transfer in rabbits. In
addition, we conduct a TÜBİTAK (Scientific and
Technological Research Council of Turkey) project
on investigation of neuroprotective properties of curcumin coated with star block-copolymer.
Asst. Prof. Dr. Mutlu Küçük
+90 212 4400000 - 33372
[email protected]
MOLECULAR METABOLIC RESEARCH LABORATORY
V
arious biological molecules and
metabolites are analyzed to investigate effects of etiopathogenesis of multifactorial diseases and individual and/or environmental variations
on metabolism.
Real time PCR, Western Blot device and its equipment, Luminex, Atomic absorption device, ELISA
reader, ELISA washer, Chemiluminescence.
We work in cooperation with Casablanca Hassan II
University (Morocco), İstanbul Faculty of Medicine
(Turkey), Cerrahpaşa Faculty of Medicine (Turkey),
İstanbul University Faculty of Dentistry (Turkey),
Bezm-i Alem University (Turkey), Fatih University
(Turkey), İstanbul Technical University (Turkey),
Uludağ University (Turkey) and many other universities. Furthermore, interdisciplinary projects supported by TÜBİTAK (Scientific and Technological
Research Council of Turkey) are under way. Our collaborative research, as part of Technocity project with
Uludağ University, on developing a combined kit to
help perform personalized chemotherapy for cancer
patients continues.
Prof. Dr. İlhan Yaylım
+90 212 4142000 – 33329
[email protected]
49
INSTITUTE of EXPERIMENTAL MEDICAL RESEARCH ISOLATION and
TRANSPLANTATION of ISLETS of LANGERHANS RESEARCH LABORATORY
I
t has pioneered in experimental isolation and transplantation of islets from
experimental animals since 1990s
and is the first institution in Turkey to
perform isolations of islets of Langerhans from human pancreases, and has
laid the foundation for performance of
transplantation in the clinic.
Class 100,000/10,000 laminar flow sterile room
at the size of 50 m2 and positive pressure, Class II
safety cabinet, Pancreas digestion chamber (Ricordi’s Chamber), Enzyme perfusion device, Peristaltic
pump, Dissection microscope, Islet purification device.
We continue our studies with University of Giessen
50
(Germany) on regenerative treatment of Type 1 diabetes and development of new technologies for pancreatic beta cell proliferation as part of a TÜBİTAK
Turkey) INTEN-C project.
Prof. Dr. M. Temel Yılmaz
+90 212 4142000 - 33370
[email protected]
HEMATOPOIETIC and STEM CELL LABORATORY
W
e conduct projects to gain understanding of altered structure, of character and of functions of hematopoietic stem cells that
convert into cancer stem cells due to
various mutations. Hematopoietic stem
cell and cancer stem cell, role of endothelial progenitor cells and endothelial cells in thrombosis, myeloproliferative
diseases from hematological malignities and frequently occurring mutations
are investigated.
Coagulometer, Laminar flow cabinet, Cell culture
laboratory, Micro-centrifuge, PCR device.
We continue joint projects with Mount Sinai School
of Medicine (USA) and Academy of Sciences (Bulgaria). We currently conduct a TÜBİTAK (Scientific
and Technological Research Council of Turkey) project that involves investigation of characterization
and of functional analysis of cancer-initiating cells
in myeloproliferative diseases, and a COST project
that involves “examination of effects of JAK2V617F
mutation on endothelial cell functions”.
Asst. Prof. Dr. Selçuk Sözer
Tokdemir
+90 212 4142000 - 33317
[email protected]
51
HULUSİ BEHÇET LIFE SCIENCES RESEARCH LABORATORY
H
52
UBAL is a multidisciplinary, central research laboratory with a
great infrastructure and required
instruments for life sciences research,
established at İstanbul University as
part of a project supported by Ministry
of Development of Turkey. Units active
in the fields of Genomics, Neuroscience,
Biotechnology, and Drug Research/
Pharmaceutics have been completed in
2014 and many projects have been initiated in these fields. We aim to contribute to translational research in healthcare with the infrastructure established.
HUBAL has been structured so as to
make its equipment park accessible not
only for researchers from İstanbul University, but also from other universities
and research institutions.
3.0 Tesla Magnetic Resonance Imaging (MRI) System, Functional MR (fMRI) Attachment (visual,
auditory stimulus presentation system and response
buttons), MR Compatible Digital EEG System, Laser Scanning Confocal Microscope, Ultracentrifuge,
Real-time Polymerase Chain Reactor, Piezo Impact
Micromanipulator, Vertical Air Flow Cabinet, Liquid Nitrogen Storage System, CO2 Incubator, Individually Ventilated Plexiglas Animal Cages.
We conduct projects, one of which is supported by
EU (JPND), two of which are supported by COST
and two of which are supported by TÜBİTAK (Scientific and Technological Research Council of Turkey) ARDEB, in collaboration with Bezmialem University (Turkey), Bilgi University (Turkey), Marmara
University (Turkey) and Boğaziçi University (Turkey). We have initiated cooperation with Max Planck
Institute (Germany), Berlin Brain and Mind Institute
(Germany) and Cuban Neuroscience Center (Cuba).
A protocol has been signed between Drug Research/
Pharmaceutics Unit and Novartis as part of University-Industry Cooperation. We work in coordination
with Life Sciences and Technologies Application and
Research Center of Boğaziçi University.
Prof. Dr. Zeynep Çiğdem Kayacan
+90 212 4400000 - 10735
[email protected]
53
NATURAL SCIENCES
and ENGINEERING
RESEARCH
LABORATORIES
FACULTY of SCIENCE
OBSERVATORY IST60 TELESCOPE
W
56
e perform photometric observations of binary stars, asteroids and planets orbiting other stars (exoplanets) and determination
of both positions and orbital elements
thereof. This observatory contributes
to international campaign observations
organized for identification of planets
that are in exoplanetary systems, but
cannot be identified by direct observations. Furthermore, it also contributes
to projects aimed to discover asteroids
that may pose a threat to the Earth and
determine whether there are any changes in their orbits compared to previous
ones. In addition, we follow changes in
orbital periods of binary star systems
which account for a significant part of
our astrophysical knowledge.
A Ritchey-Chrétien optical telescope with a main
mirror of 60 cm aperture, Alta U42 model CCD
camera with E2V series (CCD42-10) chip, 13.5 x
13.5 microns 2048 x 2048 array pixels, 9-slot filter
wheel, Bessel UBVRI and Strömgren uvby-Hβ filter
sets, meteorology station.
This observatory was founded on premises of Çanakkale Onsekiz Mart University Astrophysics Research
Center and Ulupınar Observatory (Turkey) by a
protocol based on shared observation time using our
university’s resources. Additionally, it contributes to
Council of Turkey) projects. A 5-year research protocol encompassing subjects such as extra-galactic
astronomy, cosmology, analyses of images and astronomical catalogues and stellar astrophysics has been
signed with Cote d’Azur Observatory (France) as of
June 2014.
Prof. Dr. Adnan Ökten
Prof. Dr. A. Talat Saygaç
+90 212 4440000 - 10295
[email protected]
+90 212 4440000 - 10282
[email protected]
FACULTY of SCIENCE
SOLAR OBSERVATORY
S
olar observations are made on a
daily basis using a mechanism of
two separate telescopes attached
to an astrograph which forms the main
body. The solar activity is monitored
based on sunspots and solar flares.
One of the observation mechanisms
is used to draw the projection disc of
the photosphere (light sphere). Second
mechanism is used for Hα CCD imaging and monitoring of chromosphere
(color sphere). Obtained data are archived both digitally and physically.
Astrograph with a 30 cm aperture and 150 cm focal
length, Photospheric telescope with a 13 cm aperture
and 200 cm focal length, Chromospheric telescope
with a 12 cm aperture and 232 cm focal length, Interference filter with a wavelength of 6562.8 Å and
a bandwidth of 0.3 Å, A flip-mirror system and an
eyepiece, An SBIG-STL series (11000M) astronomical CCD camera with a 4008 x 2672 pixel chip, Meteorology station.
57
Photospheric data obtained are shared with Solar Influences Data Analysis Center (Belgium). We have
initiated a 5-year research protocol with Instituto
Ricerche Solari Locarno (Switzerland) as of March
2014 covering solar physics subjects.
Assoc. Prof. Dr. Nurol Al
Asst. Prof. Dr. Mevlânâ Başal
+90 212 4440000 - 10288
[email protected]
+90 212 4440000 - 10283
[email protected]
FACULTY of SCIENCE
CELL and TISSUE CULTURE LABORATORY
E
58
ffects of environmental factors on
male reproductive system and development are examined in vitro.
Various studies are conducted on development and health of male reproductive system. For instance, agonist and
antagonist impacts of substances as
arsenic and flouride consumed via diet
on reproductive cells. The metabolic
products of substances are investigated on receptor binding levels as well as
hormone inhibition and induction pathways. Studies conducted in this laboratory with cell lines such as TM3 (Leydig)
and TM4 (Sertoli) of male reproductive
system reveal that environmental factors affect the metabolic pathways during development of male reproductive
system. Moreover, embryonic development of various living organisms is examined.
Laminar flow cabinet, Fluorescence inverted microscope and imaging system, Deep freezer (-80°C),
Ultrasonicator, Multi-scan spectrum, Homogenizer.
We conduct collaborations and projects on xenobiotics, infertility and production of mature sperm from
stem cells with Çanakkale Onsekiz Mart University
(Turkey), Yeni Yüzyıl University (Turkey), Technical
University of Dresden (Germany), University of Porto (Portugal) and Joint Research Centre of Institute
for Health and Consumer Protection (Italy).
Prof. Dr. Melike Erkan
+90 212 4555700 - 15021
[email protected]
FACULTY OF SCIENCE
MOLECULAR CELL BIOLOGY RESEARCH LABORATORY
W
e investigate cell death, damage and repair mechanisms in
various in vivo and in vitro experimental disease models and human
diseases at a molecular level. Molecular studies are conducted on apoptosis,
necrosis, autophagy, cell growth, tissue
regeneration, fibrosis, various growth
factors and cytokines-related signaling pathways, glycobiology: lectine-carbohydrate interactions and anti-cancer activities of some molecules. DNA
and RNA isolation, analysis and imaging, gene expression analyses: RT-PCR,
in-situ hybridization, various glycan determination and analysis methods, single and multiple immunohistochemical
and immunofluorescence methods, immunoprecipitation, 1D and 2D protein
electrophoresis and western blotting
methods are applied.
Laminar flow cabinet, Ultrasonic water bath, PCR
system, Fluorimeter, Refrigerated centrifuge, Homogenizer, Vertical and horizontal electrophoresis
systems, IEF system, Gel imaging device, Inverted
microscope with fluorescence attachment.
We conduct collaborative studies with İstanbul
Technical University (Turkey), Marmara University
(Turkey), Helmholtz Zentrum München - German
Research (Germany), Universidad Nacional Autonoma de Mexico (Mexico), and University of Maryland
(USA). TÜBİTAK (Scientific and Technological Research Council of Turkey) funded research and development projects are being conducted.
Prof. Dr. Şehnaz Bolkent
+90 212 4555700 - 15079
[email protected]
59
FACULTY of SCIENCE
BIOCHEMISTRY RESEARCH LABORATORY
C
60
ell death, damage and tissue repair mechanisms are investigated
biochemically. Also, biological activities of new molecules are examined
therapeutically in various experimental
disease models and human diseases.
Protein isolation and purification, protein assays, determination of enzyme
activities, oxidant/antioxidant parameters, apoptotic and necrotic markers,
inflammatory and anti-inflammatory
agents, and various growth factors and
cytokines are analyzed by ELISA, spectrophotometric, colorimetric and electrophoretic methods in animal tissue
homogenates, cell lysates, blood, serum, plasma and bronchoalveolar fluids.
Spectrophotometer, ELISA reader, Refrigerated centrifuge, Homogenizer, Horizontal and vertical electrophoresis systems, Transilluminator, Ultrapure water system, Deep freezer -86°C, Vortex.
We conduct TÜBİTAK (Scientific and Technological Research Council of Turkey) funded research
and development projects on activity mechanisms of
therapeutic new molecules in various disease models.
Furthermore we have completed national and international patent applications about a new molecule
proposed to be used in treatment of some pulmonary
diseases. We have collaborations with Department
of Chemistry from Faculty of Engineering, Department of Chest Medicine from Cerrahpasa Medical
Faculty (Turkey), Marmara University (Turkey),
Helmholtz Zentrum München - German Research
Center (Germany), University of Antwerp (Belgium), and University of Maryland (USA).
Assoc. Prof. Dr. Füsun Öztay
+90 212 4555700 - 15044
[email protected]
Asst. Prof. Dr. Pelin Arda
Pirinççi
+90 212 4555700 - 15081
[email protected]
FACULTY of SCIENCE
PRIMARY-STEM CELL and CANCER RESEARCH LABORATORY
T
his laboratory consists of Primary
and Stem Cell Culture Research
Laboratory, and Cancer Cell Culture Research Laboratory. In Primary-Stem Cell Culture Research Laboratory, pancreatic beta cells were isolated
for the first time in Turkey and single cell
studies were conducted by long-term
culture applications. Molecular mechanisms affecting beta cells in diabetes are investigated by trying to unveil
mechanisms of cell death, damage and
repair in diabetes. Our research group,
studying primary pancreatic beta cells
isolated from in vivo experimental hyperglycemic and diabetic animals and
islet-derived mesenchymal stem cells,
aim to make a fundamental contribution to therapeutic approaches to human health, and ensure implementation
of studies by building a bridge between fundamental sciences and clinical sciences. In addition, mechanisms
that may contribute to process of fibrosis in cGRP and GRP-stimulated human
pulmonary primary fibroblast cells and
mouse primary type II pneumocyte are
investigated. In Cancer Cell Culture Research Laboratory, researches on Insulinoma cell line (INS-1), pancreatic ductal
cell line ARIP, pancreatic acinar cell line
AR42J, breast cancer cell lines (MCF-7
and MDA- MB 231), C6 glioma cell line,
follicular, papillary and anaplastic thyroid carcinoma lines are conducted.
Laminar flow cabinet, Ultrasonic water bath, Inverted microscope, Autoclave, UV cabinet, Deep freezer
-152°C, Flow cytometry.
We conduct international collaborative studies with
Helmholtz Zentrum München - German Research
Center (Germany), Universidad Nacional Autonoma de Mexico (Mexico) and University of Maryland
(USA) as well as TÜBİTAK (Scientific and Technological Research Council of Turkey) funded research
and development projects.
Assoc. Prof. Dr. Selda Gezginci
Oktayoğlu
+90 21 2 4555700 - 15084
[email protected]
Assoc. Prof. Dr. Engin Kaptan
+90 212 4555700 - 15089
[email protected]
61
FACULTY of SCIENCE
RADIOECOLOGY LABORATORY
Q
62
ualitative and quantitative analyses of gamma (137Cs, 40K, 232Th
and 238U series) and alpha-emit210
ting ( Po) radionuclides in terrestrial and marine samples are performed
using gamma spectrometry equipped
with a high-purity Ge detector and alpha
spectrometry. Sediment core, sediment
trap and mussel transplantation methods are used in biomonitoring studies.
Furthermore bioaccumulation kinetics
of radionuclides and metals in marine
invertebrates is studied.
We conduct collaborative studies with İstanbul
Technical University Faculty of Mines Department
of Geology (Turkey) within the scope of TÜBİTAK
Turkey) project and with Kocaeli University Faculty
of Sciences Department of Biology (Turkey) in determination of contaminants (radionuclide, metal and
organic) in Golden Horn by active bio-monitoring
methods. We work in collaboration with University
of La Rochelle (France) and Environmental Laboratory of Monaco (Monaco) on accumulation of radionuclides in marine invertebrates under high CO2
conditions, and with University of Lisbon Institute
of Technical Sciences (Portugal) on 226Ra, 238U, 232Th,
Pu, 210Po measurements in marine organisms.
238+239
Gamma spectrometer (with a high-purity Ge detector), Alpha spectrometer (with eight ion-implanted
silicon alpha detectors with an active area of 300
mm2).
Assoc. Prof. Dr. Murat
Belivermiş
+90 212 4555700 - 15077
[email protected]
Assoc. Prof. Dr. Önder Kılıç
+90 212 4555700 - 15090
[email protected]
FACULTY of SCIENCE
MOLECULAR CANCER BIOLOGY LABORATORY
S
tudies on routine cellular passages of normal and tumoral cell lines,
and cellular and molecular analyses are conducted. Moreover, cytotoxicity analyses of various antineoplastic agents and plant extracts in cell and
tissue culture, cell kinetics parameters
(Mitotic Index, Labelling Index and Apoptotic Index), DNA damage and repair
pathways, cell cycle and expressions
of genes involved in cell death types as
well as radiosensitivity and chemosensitivity studies are conducted.
Optical microscope (phase-contrast and fluorescence), Laminar flow cabinet, CO2 incubator, Refrigerated centrifuge, PCR system, Electrophoresis
system, Qiaxcel imaging device (As many as 96 samples can be analyzed at as low concentrations as 3-5
base pair).
We conduct joint studies with American Association
for Advancement of Science (USA), European Association for Cancer Research (UK) and Migal-Galilee
Research Center (Israel).
Assoc. Prof. Dr. Gül Özcan
Arıcan
+90 212 455 57 00 - 15093
[email protected]
63
FACULTY OF SCIENCE
IMMUNOHISTOCHEMISTRY RESEARCH LABORATORY
V
arious studies are conducted using TUNEL method where apoptotic cells are exhibited by immunohistochemical labeling of enzymes
and hormones in appropriate tissues in
different experimental models, including primarily diabetes, sepsis, epilepsy
and cancer induced in mice and rats.
Rotary microtome, Microscopic image analysis system.
We work in collaboration with University of Amsterdam Academic Medical Center (The Netherlands), Bezmialem Foundation University (Turkey)
and Giresun University (Turkey). We also conduct
projects where immunohistochemical methods are
64
used in various tissues sampled from different experimental models as part of TÜBİTAK (Scientific and
Technological Research Council of Turkey) projects.
Prof. Dr. Kadriye Akgün Dar
Prof. Dr. Cihan Demirci Tansel
+90 212 4555700 – 15101
+90 212 4555700 – 15099
[email protected]
[email protected]
FACULTY of SCIENCE
PHYSIOLOGY RESEARCH LABORATORY
W
e perform physiological studies, circulatory and nervous
system applications, microcirculation studies, investigation of effects
of various endogenous and exogenous
agents against acute and/or chronic ischemia/reperfusion injury and studies
on determination of cardiac parameters
in Langendorff Isolated Heart System,
and various studies regarding neurodegenerative diseases on different animal
models (sepsis, diabetes, hypertension,
hyperglycemia, epilepsy, hemorrhagic
shock etc.) by real time measurements
under anesthesia.
Langendorff isolated heart system, Homogenizer,
ultra-pure water purification system, Powerlab 8Sp
chart recorder and scope software, Bio amplifier,
bridge amplifier, Blood pressure transducer, Blood
flowmeter, Fine needle probe, Infusion pump, Ventilator, Stereotactic surgery system.
We conduct collaborative studies with University of
Amsterdam Academic Medical Center (The Netherlands), Bezmialem Foundation University (Turkey),
Giresun University (Turkey) and Karadeniz Technical University (Turkey). We also conduct projects
on effects of various agents in Langerdorff Isolated
Heart System and septic shock in vivo electrophysiological data acquisition system and circulatory and
renal functions in different experimental models as
part of TÜBİTAK (Scientific and Technological Research Council of Turkey) projects.
Prof. Dr. Cihan Demirci Tansel
+90 212 4555700 – 15099
[email protected]
65
FACULTY of SCIENCE MOLECULAR RADIOBIOLOGY and
BIOMOLECULAR TECHNOLOGY RESEARCH LABORATORY
I
66
n preclinical cancer research, besides
treatment of cancer by chemotherapeutic agents and various extracts,
regulation of treatment of cancer by
cellular aging, aromatase inhibitors, nanotechnological drugs and hyperthermia are investigated as well. Studies on
subjects such as Labelling Index, Mitotic Index, Apoptotic Index, and Cell Index,
Mitochondrial dehydrogenase activity
assay, tyrosine kinase activity assay, hyperthermia applications and evaluation
continue.
Laminar flow cabinet, Inverted microscope, Optical
microscope, Centrifuge, Deep freezer -20oC, Deep
freezer -70oC, Precision scales, Distilled water system, xCELLigence Real Time Cell analysis system,
CO2 incubator, Shaker incubator, MagCellect devices.
We conduct joint studies with Marmara University
Faculty of Pharmacy (Turkey), İstanbul Faculty of
Medicine (Turkey), İstanbul University Cerrahpasa
Faculty of Medicine (Turkey), İstanbul University
Faculty of Pharmacy (Turkey) and American Association for the Advancement of Science (AAAS), American Society Therapeutcal Radiology and Oncology
(ASTRO) and European Society Therapeutical Radiology and Oncology (ESTRO).
Asst. Prof. Dr. Mehmet R.
Topçul
+90 212 4555700 - 15097
[email protected]
FACULTY of SCIENCE PLANT BIOTECHNOLOGY and GENETICALLY
MODIFIED ORGANISMS LABORATORY
Q
ualitative and quantitative analysis of genetically modified organisms (GMO), reproduction of
certain gene regions, quantitative determination of functional genes, determination of gene expression and analysis
of specific genes are performed using
RT-PCR. In addition, studies such as
DNA, RNA, protein isolations, Southern,
Northern and Western blotting, gel electrophoreses and imaging of protein and
nucleic acids, microproduction of endemic or endangered plants by tissue
culture, and determination of polymorphism and phylogenetic relationships
between species by molecular marker
techniques are conducted.
Council of Turkey) funded projects and COST projects as well as other EU-supported collaborative
studies on molecular approaches for increasing starch
synthesis of plants which is of nutritional, industrial
and economic importance with Koç University (Turkey), “Taxonomic Revision of Campanula: Sections
Symphyandriformes, Rupestres, Scapiflorae, Saxicolae, Tracheliopsis, Dictyocalyx and Platysperma and
their Phylogenetic relationships in Turkey and 2012COST ACTION: Omics Technologies for Crop Improvement, Traceability, Determination of Authenticity, Adulteration and Origin in Saffron continues.
This laboratory has a potential to conduct routine
GMO analyses. We conduct collaborative studies
with National Institute for Scientific Agricultural
Research (France) for development of new GMO
analysis methods.
Real-time PCR, Nanodrop 2000 spectrophotometer,
Geliance 200 imaging system, 3 - 30 K ultracentrifuge.
Prof. Dr. Gül Cevahir Öz
Prof. Dr. Mahmut Çalışkan
+90 212 4555700 – 26808
[email protected]
+90 212 4555700 - 26850
[email protected]
67
FACULTY of SCIENCE
ENVIRONMENTAL and INSTRUMENTAL ANALYSIS LABORATORY
D
68
etermination of elemental contents of plants, soil, water and
sediment samples, purifications,
characterization of peptides and proteins, fractionation of such molecules
as amino acids, vitamins, such contaminants as pesticides and polycyclic
aromatic compounds have been conducted and detection studies for such
various chemical compounds as volatile oils and fatty acids in samples and
high molecular weight biopolymers are
performed.
ICP-optical emission spectrometer, Ultrahigh performance liquid chromatography, Gas chromatography-mass spectrometry, Microwave oven system, Fat
extractor.
We conduct collaborative studies with Yıldız Technical University (Turkey), University of Orleans
(France), Bielefeld University (Germany), University of Oslo (Norway) and University of Debrecen
(Hungary). TÜBİTAK (Scientific and Technological
Research Council of Turkey) funded projects and research and development projects within the scope of
University-Industry Cooperation are being conducted and the laboratory has a potential and capacity to
perform routine analyses.
Prof. Dr. Gül Cevahir Öz
+90 212 4555700 – 26808
[email protected]
Assoc. Prof. Dr. Gülriz Bayçu
Kahyaoğlu
+90 212 4555700 – 26808
[email protected]
FACULTY of SCIENCE FUNDAMENTAL and INDUSTRIAL
MICROBIOLOGY RESEARCH LABORATORY
W
e conduct studies on isolation
and identification of Legionella, sulphate-reducing bacteria
and sulphur-oxidating bacteria, free living amoeba, microbiological corrosion,
determination of antibacterial activity,
disinfectant effectiveness studies (suspension, biofilm), microbiological food
analysis, isolation of bacteria reducing sulphur from petroleum and methane-producing bacteria, biological quality determination of various products,
mycology, aerobiology, determination
of internal and external air quality, water
pollution, quorum sensing, biofilm tests
and characterization in man-made water systems.
Identification of bacteria (Epifluorescence microscope, Gradient PCR), Community analysis (Denatured gradient gel electrophoresis), Anaerobic culture
methods (Glovebox), Electrochemical microbiological corrosion trials (Potentiostat-Galvanostat device),
Environmental molecular microbiology studies (Nanodrop-ELISA reader), Microbiological air quality
(Air sampler).
We have academic collaborations with Yıldız Technical University (Turkey), Boğaziçi University (Turkey), Trakya University (Turkey), Delft University
of Technology (The Netherlands), Flinders University (Australia), and Turkish Petroleum Corporation
(TPAO). We conduct projects on microbiological
characterization of petroleum produced in Turkey,
microbiological corrosion of metals in cooling towers within the scope of project funded by TÜBİTAK
Turkey) and make preparations for commercialization and patent applications for anti-biofilm nanotechnological coatings.
Prof. Dr. Ayşın Çotuk
+90 212 4555700-15069
[email protected]
69
FACULTY of SCIENCE MOLECULAR RADIOBIOLOGY and PLANT
BIOTECHNOLOGY RESEARCH LABORATORY
P
70
utative-mutant plants, with tolerance to various abiotic stresses, including drought, salinity and
herbicides have been produced in various plants, including sugar beet, potato, wheat and soybean by using a combination of Plant Mutation Breeding and
Molecular Biology techniques. Gamma
irradiation of in vitro and in vivo samples
has been used to improve these target
traits. Desired mutants are screened
using molecular and biochemical techniques. Various plant species, which
have agricultural and economic importance, are propagated by plant tissue
culture techniques.
Laminar flow cabinet, Incubator, Precision scales,
PCR cycler, Nanophotometer, Growth cabinet
(Nuve), Plant growth cabinet (Sanyo), Centrifuge,
Gel running vertical and horizontal electrophoresis
tanks.
We have an ongoing collaboration with Join FAO/
IAEA Nuclear Techniques in Food and Agriculture,
Plant Breeding and Genetics Laboratory (Austria).
Asst. Prof. Dr. Sema
Alikamanoğlu
+90 212 455 57 00 - 15094
[email protected]
FACULTY of SCIENCE
PLANKTON CULTURE LABORATORY
W
e conduct studies on diagnosis and production of dinoflagellate cysts found particularly
in sea sediment within the frame of production and culturing of microscopic organisms found in our waters in laboratory environment.
Incubator, autoclave, Ultrasonic bath, Precision
scales, Photometer, Optical microscope and imaging
system.
International bilateral collaboration project “Microalgae resting cysts in recent marine sediments and
their role in establishment of Harmful Algal Blooms
(HABs) in three eutrophicated bays in Greece and
Turkey” supported by TUBITAK (Scientific and
Technological Research Council of Turkey) -GSRT
(Greece) partnership has been conducted.
Prof. Dr. Neslihan Balkıs
Asst. Prof. Dr. Benin Toklu Alıçlı
+90 212 455 57 00 - 15115
[email protected]
+90 212 455 57 00 - 15147
[email protected]
71
FACULTY of SCIENCE
ISTF (HERBARIUM)
I
t is an international herbarium registered in Index Herbariorum since
1956. Every year, national and international researchers visit herbarium to
conduct studies on more than 40000
plants including samples of a high historical and scientific value.
Scanning Electron Microscope (Jeol JCM 5000 Neoscope Benchtop), Photomicroscope and Stereomicroscope (Olympus SZX16)/Photography and measurement, Optical microscopes and stereomicroscopes
for dissection
It is in contact with all formal and registered herbariums in the world and admits visitors.
72
Assoc. Prof. Dr. Osman Erol
+90 212 4555700 - 26820
[email protected]
FACULTY of SCIENCE
NANO and OPTOELECTRONIC RESEARCH LABORATORY
O
ptical and electrical characterization of novel semiconductor
materials and electronic/optoelectronic devices based on semiconductors at a wide range of temperature (2 – 300 K), investigation of charge
transport phenomena in solid materials
by magneto-transport, detection of defect levels, synthesis and characterization of nanostructures and investigation
of magnetic properties of semiconductors are the main research activities.
We conduct collaborative studies with Anadolu University (Turkey), Cumhuriyet University (Turkey),
Sakarya University (Turkey), Akdeniz University
(Turkey), University of Essex (UK), Tampere University of Technology (Finland), LAAS (France),
and Victoria University (Canada). We conduct
Council of Turkey) funded projects on electrical/optical properties of novel semiconductor alloys, design
and characterization of photodetectors for optical
Optical characterization (spectral photoconductivity,
spectral photovoltage, reflection, modulation spec-
communication and COST projects on development
of novel gain materials/devices based on semiconductors alloys and devices operating in THz region.
troscopy, photoluminescence) from UV (200 nm) to
IR (10 µm) region between 2 and 300 K, Electrical
characterization (a.c. and d.c. Current-Voltage Measurements), Hall Effect measurement system (2.3 T,
10 - 300 K), Magneto-transport set-up (7 T, 4 - 300
K), Defect spectroscopy (PITS), Liquid nitrogen
generator with a production capacity of 40 l/day.
Prof. Dr. Ayşe Erol
+90 212 4555700 - 15005
[email protected]
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FACULTY of SCIENCE
ADVANCED LITHOGRAPHIC METHODS LABORATORY
A
74
dvanced Lithographic Methods
Laboratory has been established
in 2014 as an outcome of Ministry of Development-funded infrastructure project and comprises of a clean
room area of 100 m2 with Class 10,
100 and 1000 sections. The laboratory facilities are suitably equipped to enable studies on fabrication of electronic/
optoelectronic devices by photolithography and dry etching techniques at a
nano/micro scale, imaging of surfaces
and cross-sections of solids and determination of elemental composition of
materials.
Wet bench equipped with spin coater, Hot plate,
Ultrasonic cleaner, Chemical bench, Mask aligner
(SUSS MJB4), Thermal evaporator (VAKSIS), Profilometer (KLA Tencor P6), Wire bonder (Kulicke
&Soffa), Dry etching equipment (FEI Versa 3D
Dual Beam Focused Ion Beam / RAITH Electron
beam system), SEM (FEI), AFM (Park Systems),
EDS (FEI).
It is aimed to initiate and conduct collaborative research with Anadolu University (Turkey), Cumhuriyet University (Turkey), Sakarya University (Turkey),
Akdeniz University (Turkey), University of Essex
University (UK), Tampere University of Technology (Finland), LAAS (France) and Victoria University (Canada) on fabrication and characterization of
novel semiconductor structures and optoelectronic/
electronic devices.
+90 212 4555700 - 15005
[email protected]
FACULTY of SCIENCE
HIGH MAGNETIC FIELD and LOW TEMPERATURE LABORATORY
H
igh Magnetic Field and Low Temperature Laboratory, founded in
2012 as an outcome of a Istanbul University-funded project, is suitably
equipped to enable studies on investigation of charge transport mechanisms
in solid materials and semiconductor
devices at a variable magnetic field and
low temperatures, magnetic field-dependent conductivity, classical Hall Effect and quantum Hall Effect, electrical characterization and investigation of
magnetic properties of solids.
18/20 T Superconducting magnet system with a dilution refrigerator (10 mK), Superconducting magnet system (7 T, 4.2 - 300 K), Helium recycling system and helium liquefier system (18 l/day).
It is proposed to conduct collaborative studies and
projects with University of Essex (UK), Tampere
University of Technology (Finland), LAAS (France),
INSA (France) and Victoria University (Canada)
based on investigation of magneto-transport properties of semiconductor materials, classical and quantum Hall Effects, charge transport in solids.
+90 212 4555700 - 15005
[email protected]
Asst. Prof. Dr. Saffettin
Yıldırım
+90 212 4555700 – 15424
[email protected]
75
FACULTY of SCIENCE
MOLECULAR SPECTROSCOPY LABORATORY
C
76
haracterization of molecular
structures, identification of functional groups and determination
of crystallinity are among the main activities of this laboratory. The structural
analysis of the drugs used in the treatment of important diseases and their
interactions with the media are being
studied spectroscopically. Detection of
the effects of various diseases at molecular level is also aimed (identification
of cancerous tissues, studies on osteoporosis etc.). In addition, the structural
analysis of archaeological findings and
determination of the chemical compositions of semiconductor alloys are included in its range of activities. All of
these experimental studies are further
supported by molecular simulation calculations.
Fourier Transform Infrared Spectrometer (Medium
and near-IR), Fourier Transform Raman Spectrometer (50 – 3600 cm-1 spectral range, 1064 nm wavelength and 1 W laser source), Micro Raman dispersive spectrometer (50 – 8000 cm-1 spectral range,
785 nm and 532 nm wavelength and 100 mW laser
sources).
We have collaborative studies with University of
Potsdam (Germany), Oral Roberts University (USA),
Uzhgorod University (Ukraine) and Politechnico di
Milano (Italy). Molecular structure and vibrational
analysis studies as part of TÜBİTAK (Scientific and
Technological Research Council of Turkey) projects,
and structural analysis and electronic band gap studies of amorphous solids as part of a TÜBİTAK International Bilateral Cooperation project are among he
conducted projects.
Prof. Dr. Ayşen E. Özel
Prof. Dr. Elif Akalın
+90 212 4555826
[email protected]
+90 212 4555700 - 15445
[email protected]
FACULTY of SCIENCE
LASER SPECTROSCOPY LABORATORY
L
aser Spectroscopy Laboratory, established in 2012 with the support of Istanbul University, currently deals with determination of hyperfine
structure constants from atomic spectra of elements, and determination of
unknown spectral lines of atoms. Hyperfine structure constants are also
used in astrophysics. Accordingly, it is
an area befitting interdisciplinary studies.
In order to examine the hyperfine structure of atoms
and to find new energy levels, Laser Induced Fluorescence Spectroscopy (LIF), Saturated Absorption
Spectroscopy (SAS) and Opto-galvanic Spectroscopy
(OGS) methods are applied by using a tunable cw Titan Sapphire laser pumped by an 18 W optical power, 532 nm wavelength, Cw solid-state laser (having
an optical power of 4 W operating within 700 and
1100 nm range, Continuously tunable at 30 GHz).
77
We have bilateral collaborative projects and studies
with HTW Berlin (Germany), Latvia University
(Latvia), Graz Technical University (Austria) and
Poznan Technology University (Poland), aimed at
experimental and theoretical identification of fine
structure parameters and hyperfine structure constants of atoms, and determination of new energies
of atoms.
Prof. Dr. Gönül Başar
+90 212 4555843
[email protected]
FACULTY of SCIENCE
DIELECTRIC SPECTROSCOPY LABORATORY
D
78
ielectric Spectroscopy Laboratory,
established in 2012 with the support of Istanbul University, is capable of producing oxide and polymer
materials by using different techniques
such as electron beam, thermal evaporation, rf and magnetron sputtering. Dielectric characteristics (capacity, dielectric loss, AC conductivity, relaxation
time, etc.) of bulk and powder materials, thin films, polymers and liquid samples within 3 µHz – 20 MHz frequency
and 173 K – 373 K temperature ranges, and DC conductivity of bulk and thin
films are studied.
A vacuum system (10-6 Torr with a thickness monitor) and Dielectric Conductivity and Impedance
Measurement System operating within 3 µHz – 20
MHz frequency and 173 K – 373 K temperature
ranges and ELGA Purelab Options-S7/15 water purification system.
We have collaborative projects and studies with Marmara University (Turkey) and Bahçeşehir University
(Turkey) on growth and characterization of materials for industrial needs, biological liquids, and an
international collaboration with Charles University
(Czech Republic).
Prof. Dr. Deniz Değer Ulutaş
+90 212 4555700 - 15292
[email protected]
FACULTY of SCIENCE
NUCLEAR PHYSICS RESEARCH LABORATORY
N
uclear Physics Research Laboratory was established in 2014 with
the support of Istanbul University. Nuclear Physics Laboratory consists
of Gamma Spectroscopy and Radon
Measurement Laboratories. Gamma
Spectroscopy Laboratory can handle
vast variety of samples including food
(tea, hazelnuts, etc.), drink, industrial
materials and products (fertilizers, coal,
cement, ceramic, marble, granite, etc.)
for preparation and measurements. Radon Measurement Laboratory is capable of performing active and passive
radon concentration measurements in
soil, water and air samples and carries
out research activities related with environmental radiation safety, earthquake
– radon relation.
A high resolution Gamma Spectroscopy System composed of a p-type Co-axial Ge (HPGe) detector with
35% efficiency for gamma energies between 40 keV
to 10 MeV, Solid state nuclear alpha track detectors
for passive radon measurements and an AlphaGuard
for active radon concentration measurements in soil,
water and air.
This laboratory is suitably equipped for future collaborations.
Assoc. Prof. Dr. Latife Şahin
Yalçın
+90 212 4555700 - 15410
[email protected]
79
FACULTY of SCIENCE
ANCIENT DNA RESEARCH LABORATORY
D
NA isolations from fossils (human, animal, plant, etc.) found in
archeological sites, and at later
stages, sex-determination and analyses
of mitochondrial, X and Y chromosome
series are carried out. The resulting series information is bioinformatically assessed, and Haplo-group studies are
conducted.
Gradient PCR and classical PCR systems, Computers and bioinformatics softwares.
We have collaborative studies and projects with Trakya University (Turkey), Süleyman Demirel University (Turkey), International Society for Computational
Biology (Italy) and International Center for Genetic
Engineering and Biotechnology (Italy), and ongoing
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projects with the Ministry of Science, Industry and
Technology.
Assoc. Prof. Dr. Ercan Arıcan
+90 212 4555700 - 15119
[email protected]
FACULTY of SCIENCE
PLANT BIOTECHNOLOGY LABORATORY
C
ultivation studies are being conducted on barley (Hordeum vulgare L.), bread wheat (Triticum
aestivum L.), rice (Oryza sativa L.), tobacco (Nicotiana tabaccum L.) and sunflower (Avena sativa L.), as model organisms for plants. Somatic variations are
studied on barley under tissue culture
conditions and especially at transposon
level, and gene expression analyses and
transposon analyses are conducted on
transgenic tobacco plants, and phenological, physiological and genomic responses are analyzed and correction of
these responses by plant hormones is
studied on barley, wheat and sunflower under abiotic stress circumstances
(salinity and heavy metals, etc.), and genetic and epigenetic methods are used
therein for. GMO analyses are carried
out on rice plant. Our Laboratory further
uses its expertise on molecular markers in genetic and epigenetic analyses
of geriatric genes in human.
Plant growth cabinets, Horizontal electrophoresis
systems, PCR systems (classical and real-time), Autoclaves, Optical microscopes, Fluorescent microscope,
Confocal microscope.
We have collaborative studies and projects with Institute for Biotechnology and Genetic Engineering
(Bosnia-Herzegovina), Sofia University (Bulgaria)
and Marmara University (Turkey).
Prof. Dr. Nermin Gözükırmızı
+90 212 4555700 - 15111
[email protected]
81
FACULTY of SCIENCE
PROTEOMICS LABORATORY
P
82
roteomic analyses (1D, 2D Electrophoresis and MS analyses) are
conducted on various biological
materials (plants, yeasts, animal cells,
stem cells, etc.) and on clinical samples. Bioactivities of proteins and peptides (especially HSPs, allergenic pollen
proteins, milk proteins and hydrolysis
products) are determined, and electrophoretic / chromatographic separation
techniques and Western-blot analysis
are carried out. Activities of various enzymes such as SOD, catalase, peroxidase, IMPDH and caspases are measured. In recombinant cells and clinical
samples developed by genetic engineering techniques, expression of oxidative
stress and apoptosis-related genes is
examined, and their protein profiles are
compared.
Vertical and horizontal electrophoresis systems,
HPLC, Isoelectric focusing device, Micro-rotator fractionation device, Gel imaging systems, Gel
drying system, Automated electrophoresis system
(Experion), Protein purification system (Profinia),
Spectrofluorometer, Quibit Spectrofluorometer, Refrigerated centrifuge, Transblotter, Western-Blot System, Digital PCR system, Fluorescent microscope,
Freeze dryer.
We have international collaborative studies and projects with Edinburgh University (UK), Joseph Fourier University and Promethee Proteomic Platform
(France), Cologne University (Germany), Marmara University (Turkey), Ege University (Turkey),
Adıyaman University (Turkey), Kocaeli University
KABI Proteomics Laboratory (Turkey), TÜBİTAK
Turkey) – Marmara Research Center Genetic Engineering and Biotechnology Institute.
Prof. Dr. Nazlı Arda
+90 212 4555700 - 15113
[email protected]
Asst. Prof. Dr. Evren Önay
Uçar
+90 212 4555700 - 15117
[email protected]
FACULTY of SCIENCE
MOLECULAR DIAGNOSIS in HUMAN DISEASES LABORATORY
O
ur laboratory is engaged in intensive research on prenatal diagnosis by fetal genomic analysis methods, and is trying to clarify
fetal physiology. Genetic diseases that
can be diagnosed by non-invasive prenatal diagnosis methods with microarray technology are researched, in addition to molecular genetic analyses for
diagnosis and treatment of genetic origin diseases. Studies aimed at finding
a new molecular marker that can be
used for diagnosis of pregnancy complications such as pre-eclampsia are
ongoing. Blood group of fetus is determined through amniotic fluid, and existence of RHD gene (blood incompatibility) of baby can be detected in maternal
blood. In cooperation with specialized
doctors, gonadic and sex-linked diseases can be diagnosed respectively from
amniotic fluid and maternal blood. Furthermore, through analysis of polymorphisms and sports-susceptibility genes
in genome, we are trying to make contri-
bution to sports and exercising.
Real-time PCR systems, Microcentrifuge, Hybridization oven, Pikofuge, Microarray scanner, Bioanalyzer, DNA/RNA extraction device.
We have international collaborative studies and projects with Sweden Genome Center (Sweden), in addition to TÜBİTAK -supported projects, and collaborations with some private clinics and SMEs.
Assoc. Prof. Dr. Tuba Günel
+90 212 4555700 - 15473
[email protected]
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FACULTY of SCIENCE
PLANT GENOMIC RESEARCH LABORATORY
T
84
his laboratory conducts studies
on Hordeum spontaneum and
Brachypodium types of barley
(Hordeum vulgare L.), a model organism for plants. Phenological, physiological and genomic responses of plants
under stress conditions are studied by
molecular methods. Expressions and
allelic variations of genes of different
pathways under conditions of drought,
salinity and combined stress are examined. The studies aimed at increasing
transformation frequency in monocot
cells through Agrobacterium tumefaciens-mediated gene transfer are also
carried out. Polymorphism studies
based on IGS-RFLP and SSR markers are conducted on our country-origin pathogen and endophyte Fusarium
types, and distribution, pathogenicity
levels and use of endophytes in agriculture are researched. Changes caused
by Fusarium infection in barley roots are
examined by physiological and genomic tools.
Plant growth cabinets, Electroporator system, Osmometer, Conductivity meter, Incubator, Microscope.
We have COST projects and collaborative studies
with Perugia University (Italy), Ondokuz Mayıs University (Turkey), and Ebittek Biotechnology R&D
Ltd. company.
Prof. Dr. Filiz Gürel
+90 212 4555700 - 15472
[email protected]
FACULTY of SCIENCE
BIOINFORMATICS LABORATORY
B
ioinformatics laboratory carries
out research on various different
DNA structures (Z-DNA, G-Quadruplex, etc.) in Yeast (S. cerevisiae and
S. pombe) genome, and determines interactions between the relevant structures and gene functions, and compares mitochondrial genome X and Y
chromosome series, and in the light of
the resulting information, assesses phylogenetic information. The studies on
identification of bioinformatics-supported molecular markers in plants are also
carried out.
Gradient PCR and classical PCR systems, Computers and bioinformatics softwares.
We have collaborative studies and projects with International Society for Computational Biology (Italy) and International Center for Genetic Engineering and Biotechnology (Italy), and some ongoing
projects with the Ministry of Science, Industry and
Technology.
Assoc. Prof. Dr. Ercan Arıcan
+90 212 4555700 - 15119
[email protected]
85
FACULTY of SCIENCE
GENETICALLY MODIFIED ORGANISMS LABORATORY
M
86
olecular studies are conducted on foreign genes in microorganisms, in addition to plants
among the genetically modified organisms. For the purpose of GMO diagnosis in plant systems, DNA isolation from
processed and unprocessed food stuff,
and foreign gene screening by qualitative and quantitative PCR, and quantification of foreign genes, and typology
of foreign genes continue. Furthermore,
studies are carried out for genomic level
determination of manipulations, which
are aimed at the change of gene expression in plants and plant products.
As part of biosafety, transformation frequency determination studies are carried out in microbial system models for
horizontal gene passage from plant organisms to animals and to soil microorganisms.
PCR system, Vertical and horizontal gel electrophoresis systems.
We have collaborative studies and projects with European Union Joint Research Center (Italy), Biosafety Board (Turkey), Union of Seed Raisers (Turkey),
Crop Central Research Institute (Turkey), in addition
to TÜBİTAK (Scientific and Technological Research
Council of Turkey) supported ongoing projects.
Prof. Dr. Şule Arı
Dr. Özgür Çakır
+90 212 4555700 - 15108
[email protected]
+90 212 4555700 - 15139
[email protected]
FACULTY of SCIENCE
PLANT PATHOLOGY LABORATORY
R
esearch is conducted on more
than 70 isolates of 4 types of
Fusarium fungi leading to Fusarium culmorum (WG Smith) Sacc. and
Pc / Phyphtora capsici in barley, wheat
and corn plants of different geographical regions. Also, ongoing are genotyping of (chromosomal and mitochondrial) isolates by using RAPD, CAPS,
PCR-RFLP, SCAR, ISSR and SSR molecular marker techniques. As part of
chemotyping of fungi, mycotoxin generation potentials of fungi are analyzed on
genomic (PCR-based) and transcryptomic (RT-PCR and real time-PCR) levels,
and existence of generated mycotoxins
is identified by thin layer chromatography analysis. As a part of gene-silencing studies on Fusarium types, synthetic siRNA molecules are designed
specifically for genes related to toxin generation, and furthermore, silencing vectors carrying the copies of these
genes are developed. Genetic manipulations in Fusarium types are carried out
at co-transformation level, and transformants are examined at morphological, genomic, transcryptomic, metabolomic and spectrofluorimetric levels.
Laminar flow cabinet, Temperature and light controlled plant growth cabinet, Shaker incubator, PCR
system, Electroporation system, Optical microscope.
87
We have an ongoing collaboration with Isfahan University of Technology (Iran).
Assoc. Prof. Dr. Gülruh
Albayrak
+90 212 4555700 - 15134
[email protected]
FACULTY of SCIENCE
PLANT SECONDARY METABOLISM ENGINEERING LABORATORY
F
88
or overproduction of plant secondary metabolites characterized as
biological active drug substances, callus, cell suspension and hairy
root cultivations and genetic transformation studies (Agrobacterium mediated and electroporation) are conducted.
For production of phenolic substances
at pilot level, actions are taken for optimization of physicochemical cultivation
conditions and for biotechnological production by elicitation. For identification
of antioxidant and cytotoxic, etc. activities of plant secondary metabolites, not
only enzyme activity tests and molecular analyses, but also analyses for secondary metabolite identification are carried out together with project partners.
Furthermore, metabolism of selenium
where anti-cancer ingredients are generated is also examined at physiological, genetic (identification and cloning
of genes operating at selenium metabolic pathway), genomic and bioinformatics levels.
PCR system, Ultra-purified water device, Nanodrop
spectrophotometer, Shaker incubator.
Projects supported by East Carolina University
(USA), TÜBİTAK (Scientific and Technological Research Council of Turkey) and the Ministry of Science, Industry and Technology are being conducted.
We have collaborative studies and projects with Ege
University (Turkey), Koç University (Turkey), Sabancı University (Turkey) and Istanbul University
Teknokent NGS Biotechnology and Sativa Biotechnology companies (Turkey).
Prof. Dr. Şule Arı
+90 212 4555700 - 15108
[email protected]
Asst. Prof. Dr. Neslihan T.
Kara
+90 212 4555700 - 15139
[email protected]
FACULTY of SCIENCE YEAST GENETICS,
TECHNOLOGY and GENOMIC RESEARCH LABORATORY
I
t is inquired how eucaryotic cells perceive their environment, and how they
regulate their biological processes in
response thereto. Accordingly, such
metabolic pathways as glucose sensing, transportation into cell, signal transmission, stress response pathways,
synthesis and destruction of depot carbohydrates, and thiamine and purine
metabolisms are researched and studied at gene, genome and biochemical levels by a combination of classical
yeast genetic methods and molecular
techniques. In addition, studies are conducted for optimization of enzymes to
be used in textile industry for production
by fermentation and chronological aging
processes at cellular metabolism levels.
ies for determination of functions of animal and plant origin genes.
Eukaryotic cell counter, Real Time and classical PCR
systems, Fermenter, Cell fractionation tools, Gel imaging systems, UV sterilization cabinet.
We have collaborative studies and projects with International Society for Computational Biology (Italy) and International Genetic Engineering and Biotechnology Center (Italy), and ongoing TÜBİTAK
Turkey) supported projects and projects with SMEs.
Studies are ongoing for creation of a S.
pombe deletion racial library in terms of
various different genes. Furthermore,
they are also used as host in clarification of various metabolic pathways and
in heterologous gene expression studLaboratory Supervisor and Contact Information
Assoc. Prof. Dr. Bedia
Palabıyık
Asst. Prof. Dr. Semian Karaer
Uzuner
+90 212 4555700 - 15467
[email protected]
+90 212 4555700 -15108
[email protected]
89
FACULTY of ENGINEERING
WASTE TECHNOLOGY RESEARCH LABORATORY
S
90
tudies are conducted for safe
and stable storage of mine tailings above ground and underground. Included among the analyses
and studies carried out in our laboratory are particle size distribution analysis of waste materials, chemical element content analysis, determination
of particle shape, compaction curves
and optimum intensity analysis, liquid
limit analysis, porosity, permeability,
slump and water contents, sedimentation and filtration, pipe flow tests, channel flow tests, yield stress, compressive
strength, shearing stress, process water
quality analysis, viscosity, liquefaction,
consolidation, desiccation cracks intensity analysis, and water holding (retention) curves analysis. At the same time,
for simulation of behavior of pasty materials at storage site, laboratory measurements and analyses are effected
under field conditions simulated in laboratory waste cabinets.
Tension/compression resistance testing machine,
Ground compactor device, Ground sampling set,
Atterberg consistency limits experiment set, Falling-head permeability experiment set, Shear box
test device, Consolidation experiment set, CBR
test device, Waste cabinets of various different sizes, Temperature – volumetric water content sensors,
Water absorption potential sensors, oxygen sensors,
Elemental analysis (XRF) device, Rheometer device,
Cure cabinet, Laboratory-type mixer, Slump experiment set.
We have collaborative studies and projects with Quebec University (Canada).
Prof. Dr. Ataç Başçetin
+90 212 4737070 - 19409
[email protected]
ORGANIC CHEMISTRY RESEARCH LABORATORY
R
eactions of polyhalogenic compounds and haloquinones with
amines, alcohols and thiols in various different solvents (protic, aprotic,
etc.) in presence of acid or base are examined, and new organic compounds
are synthesized, and chromatographic
chemical and physical characteristics
of synthesized compounds and complexes are determined, and structural
clarification studies are conducted.
FTIR (400 – 4000 cm-1), Potentiostat / galvanostat /
ZRA System (60 pA – 600 mA), UV-Vis spectrometer (200 – 900 nm), Fluorescence spectrophotometer
(200 – 900 nm), Polarimeter, Horizontal or vertical
condenser rotating evaporation systems, Microdistillation unit, Platform purification device.
We have completed a project for synthesis, characterization and activity qualification of new biologically
active substances together with Lviv Polytechnical
University (Ukraine) as a part of an internationally funded TÜBİTAK (Scientific and Technological
Research Council of Turkey) project. Furthermore,
Ministry of Development projects have also been
completed in connection therewith.
Prof. Dr. F. Serpil Göksel
+90 212 4737070 – 17779
[email protected]
91
FACULTY of ENGINEERING FOOD ANTIOXIDANTS MEASUREMENT
APPLICATION and RESEARCH CENTER
R
92
eporting of total antioxidant capacity values of food stuffs (all
kinds of solid and liquid foods)
produced and processed in our country,
and labeling according to the Turkish
Food Codex Regulation, and scavenging activity assay of food antioxidants
towards reactive oxygen types are
among the activities of our laboratory.
Antioxidant contents of food stuffs are
reported and labeled by means of CUPRAC antioxidant capacity / activity assay method. Through identification and
separation of antioxidant-rich fractions
of foods, new diet and nutrition suggestions abundantly containing these compounds are formulated.
trospray [ESI] ion source with a mass measurement
range of 2-2000 a.m.u. and a scanning rate of 10000
a.m.u./sec and an ion source capable of Multimode
[ESI and APcI) ionization and an automatic sampler
and PDA detector), UV-Spectrometer (190 – 900
nm, double beam line).
We have collaborative studies and projects with Ministry of Food and Agriculture, General Directorate of
Agricultural Researches and Policies, Istanbul Technical University (Turkey), some leading companies
(Turkey). A TÜBİTAK (Scientific and Technological
Research Council of Turkey) project aimed at development of a new spectrofluorometric method with
resorcinol probe for measurement of hypochlorous
acid scavenging activity of polyphenols is ongoing.
HPLC (UV-Vis, luorescence and PDA detector and
post-column derivatization system), Electrochemical
potentiostat/galvanostat, Mercury drop electrode cel-
Also, ongoing studies are classification and assessment of food stuffs according to their antioxidant
contents, and development of sensors for antioxidant
enzyme activity measurement.
lular set, Rotary disk electrode cellular set, UPLC/
MS/MS (Mass-Mass triple quadropole) (with ElecLaboratory Supervisor and Contact Information
Prof. Dr. Reşat Apak
+90 212 4737028
[email protected]
BIOCHEMISTRY RESEARCH LABORATORY
O
ur laboratory investigates enzyme activity assays and various
biochemical parameters assays
in animal tissue and serum samples,
and enzyme inhibition tests, antioxidant
activity assays in various plant extracts
and chemicals, enzyme purification,
enzyme immobilization, effects of various synthesized inorganic and organic
substances on enzyme activities, experimental diabetes, examination of protective effects of various chemicals and
plant extracts in experimentally created toxicity models, hyperlipidemia, and
determination of contents of plant extracts.
HPLC,
Spectrophotometer,
Spectrofluorometer,
Electrophoresis device, Gel imaging device, Frigorific centrifuge, -80°C refrigerator, Freeze dryer, ELISA
device.
We have collaborative studies and projects with Marmara University (Turkey), Yıldız Technical University (Turkey), Giresun University (Turkey), İnönü
University (Turkey) and İstanbul Aydın University
(Turkey).
Prof. Dr. Refiye Yanardağ
+90 212 4737037 - 17792
[email protected]
93
PROCESS and REACTOR DESIGN RESEARCH LABORATORY
I
ncluded among the activities of our
laboratory are production of catalytic
hydrogen from natural gas, dehydrogenation of oxidative propane, catalytic reactions such as methane pairing,
development of catalysts, such fuel cell
technologies as polymer electrolyte fuel
cells and solid oxide fuel cells, as well
as membrane syntheses, and technologies for preparation of different catalysts.
limited high temperature ovens (maximum temperatures 1750°C, 1300°C and 1000°C) and drying
ovens, BET Surface Area device, Ultrasound Device
(40 kHz).
The laboratory took part in the project titled “Electrical Neuronal Oscillations and Cognition” within
the scope of the COST program by European Union.
A joint project has been conducted with Macedonian
Academy of Sciences on EEG-Neurofeedback within
94
the scope of TÜBİTAK’s (Scientific and TechnologResearch Infrastructure of the Laboratory
ical Research Council of Turkey) Macedonia-Turkey
bilateral research support.
Gas chromatography, micro reactor-mass spectrometer combined system, Electrochemical impedance
spectroscopy (30 MHz – 1 mHz), Scanning electron
microscope (SEM), UV spectrophotometer, Test stations for solid oxide fuel cells and polymer electrolyte
fuel cells (PEMFC), Thermogravimetric analysis –
differential thermal analysis simultaneous measurement device (maximum temperature 1200°C), Contact angle measurement device, Ultrasound provider,
Prof. Dr. M. Ali Gürkaynak
+90 212 4737070- 17661
[email protected]
FACULTY of ENGINEERING GEOCHRONOLOGICAL SAMPLE
PREPARATION and MINERAL SEPARATION LABORATORY
O
ur laboratory is engaged in application of processes such as
mineral separation and enrichment of rock samples for radiochronological analyses, and separation of zircon, xenothyme, amphibole, lawsonite,
granitite, monazite, mica, etc. minerals
used for age determination, and making
them ready for analyses.
Magnetic separator, Heavy liquids and minerals flotation – sedimentation systems.
We have collaborative studies with Çukurova University (Turkey), Fırat University (Turkey), Istanbul
Technical University (Turkey), and Bulgarian Science Academy (Bulgaria), in addition to ongoing
Council of Turkey) projects.
Asst. Prof. Dr. Namık Aysal
+90 212 4737070 - 17894
[email protected]
95
FACULTY of FORESTRY
SOIL SCIENCE (AGROLOGY) and ECOLOGY LABORATORY
O
96
ur laboratory is engaged in pH,
electrical conductivity, carbon, nitrogen and other elemental analyses in plant, turf, soil and water samples,
and such analyses as texture, calcium
carbonate and water holding (retention)
capacity in soil, and studies for identification of forest ecosystems. In addition, projects are ongoing on monitoring of forest ecosystems, mapping of
forest soils, plant nutrition, rehabilitation
of mineral sites, soil pollution, phytoremediation, determination of effects of
air pollution on forests.
C/N elemental analysis device, ICP-OES, microwave
sample granulator, UV spectrometer, Flow injection
device, Nitrogen/protein device, Centrifuge device,
Frigorific incubator, Stereo microscope, pH-meter
and EC-meter.
We have collaborative studies and projects with Korean University (Korea), Debrecen University (Hungary) and Istanbul Technical University (Turkey),
Dokuz Eylül University (Turkey), Süleyman Demirel
University (Turkey) and many other universities, in
addition to ongoing joint projects with Forestry Research Institutes of the Ministry of Forest and Hydraulic Works. There are also pending TÜBİTAK
Turkey) projects pertaining to the quantity of carbon
stored in soil and plant masses in forest ecosystems in
tandem with climatic changes.
Asst. Prof. Dr. Serdar Akburak
+90 212 3382400 - 25298
[email protected]
FACULTY of FORESTRY NANOTECHNOLOGY
LABORATORY and THERMAL ANALYSIS LABORATORY
I
t is the first Nanotechnology Laboratory and Thermal Analysis Laboratory
in forest industry field (wood, wooden
composite materials, biomaterials, thermoset/thermoplastic glues, furniture) in
Turkey. It deals with research and development and innovation studies on applications of nanoscience and nanotechnology in wood industry, and with
thermal characterization of materials.
Also, ongoing are scientific and industrial projects related to development of
new generation of environmental-friendly wooden composites, development of
composites with reduced formaldehyde
emission, development of composites
with enhanced resistance and thermal
stability, and development and characterization of biomaterials, biocomposites and nanocomposites.
Thermogravimetric Analysis/Differential Thermal
Analysis (TGA/DTA) system, Dynamic Mechanical Thermal Analysis/Thermomechanic Analysis
(DMTA/TMA) system, Vacuum oven, Ultrasonic
homogenizator, Viscosimeter.
We have collaborative studies and projects with
Maine University (USA), Louisiana State University
(USA), Tennessee University (USA), Bangor University (United Kingdom), and Beijing Forestry University (People’s Republic of China), in addition to
ongoing joint research and development projects. We
also have memberships in European Union COST
actions regarding nanotechnology and composite
materials. We have also pending joint projects and
collaborations with Sabancı University (Turkey),
Istanbul Technical University (Turkey) and Bursa
Technical University (Turkey) and many other universities and non-governmental organizations.
Prof. Dr. Nusret As
+90 212 3382400 - 25361
[email protected]
97
FACULTY of FORESTRY PROF. DR. A. YILMAZ BOZKURT WOODEN
MATERIALS COMBUSTION TEST and ANALYSIS LABORATORY
O
ur laboratory is engaged in measurement of mass loss and convection speed occurring in wooden materials during combustion, and
combustion tests, thermal analyses of
wooden materials, and anti-fire performances of wood and wooden-based
products and non-wood constructional
materials.
Mass loss calorimeter, Single-flame source ignitability analyzer, Fourier Transform Infrared Spectrometer
(FT-IR).
We have collaborative studies and projects with Forestry Service, Forest Products Laboratory (USA) and
Yıldız Technical University (Turkey), on various boron products which have not yet been introduced to
98
forestry industry, and on synthesis of boron products
as a fire-retardant additive.
Prof. Dr. S. Nami Kartal
Research Assistant Evren Terzi
+90 212 3382400 - 25352
[email protected]
+90 212 3382400 - 25086
[email protected]
FACULTY of FORESTRY
ANNUAL RING RESEARCHES and WOOD ANATOMY LABORATORY
I
t is the first and single laboratory dealing with annual ring research in Turkey. Accordingly, it generates data for
various disciplines such as forestry, climate sciences, geography, archeology,
history of art, architecture, etc. The laboratory conducts its “wood annual ring”
and “wood anatomy” studies together. The history of climate in Anatolia is
studied, and annual ring data sets are
created for our natural tree species. Furthermore, wood materials found in historical buildings and archeological sites
are diagnosed, and their period of use,
and building construction and/or repair
dates are determined in reliance upon
annual ring analyses. In addition, dendrogeomorphological studies are conducted for determination of frequency
and limits of such events as avalanche,
landslide, etc. Operating as a part of
ISTO Herbarium, this laboratory is engaged not only in ecological wood anatomy researches, but also in wood anatomy leg of taxonomic revision studies
of wood-like plants, and holds an important collection of contemporary and
petrified woods.
Linear-tray and computer-aided Annual Ring Measurement Systems, Microscopes, Microtomes, Increment borers and cleaning sets of different sizes.
We have collaborative studies and projects on dendrochronology, dendroclimatology, dendroarcheology, dendroecology and dendrogeomorphology with
Arizona University (USA), Columbia University
(USA) and Purdue University (USA), in addition to
collaborative projects ongoing with various local universities such as Istanbul Technical University (Turkey), Ege University (Turkey) and Bartın University
(Turkey), and with Forestry Research Institutes.
Assoc. Prof. Dr. Nesibe Köse
+90 212 3382400 - 25323
[email protected]
99
FACULTY of FORESTRY
PROF. DR. A. YILMAZ BOZKURT WOOD ANATOMY LABORATORY
O
100
ur laboratory is engaged in detection of local and exotic tree species in the merchandized raw
materials, semi-finished and finished
products, and determination of tree
species in restoration / conservation
projects and in archeological wooden
objects, and determination of desired
quality specifications of raw material
wood at the place of use in tandem with
anatomic composition, and identification of material-based problems emerging as a result of anatomic composition
and development of resolution suggestions in Forestry Products Industry, and
determination of quality losses in wooden materials through examination of anatomic composition, and assessment
of the degree of success of industrial
processes on woods in line with changes caused thereby in anatomic composition. Furthermore, it covers Prof. Dr.
Adnan BERKEL Xylarium (ISTUFw Xylarium), being the first and single collection accepted to International Xylariums
(INDEX XYLARIUM) used for education,
scientific research, wood diagnosis and
industrial service purposes.
Stereo microscope, Optical microscope with digital imaging system with polarized and fluorescence
equipment and slide microtome.
We have collaborative studies and projects with Ministry of Culture and Tourism, Istanbul Restoration
and Conservation Central Laboratory Directorate,
National Union of Wood, Istanbul Metropolitan
Municipality, Protection Application and Supervision Directorate, National Research Institute on
Cultural Features (Japan), and Natural Resources
and Applied Life Science University (Austria). In addition to a TÜBİTAK (Scientific and Technological
Research Council of Turkey) project focused on anatomic and microbiological specifications of archeological wooden materials found in Marmaray Project
excavations (Turkey), and effects of thermal process
on anatomic composition of wood, we have carried
out projects for diagnosis of tree species in archeological wood finds of Aegean Region.
Assoc. Prof. Dr. Ayşe Dilek
Doğu
Research Assistant F. Diğdem
Tuncer
+90 212 3382400 - 25084
[email protected]
+90 212 3382400 - 25351
[email protected]
FACULTY of FORESTRY – FORESTRY PRODUCTS CHEMISTRY and TECHNOLOGY RESEARCH
LABORATORY and CELLULOSE, PAPER and CARDBOARD ANALYSIS LABORATORY
I
ncluded among its activities are clarification of chemical composition of
wood-based and non-wood lignocelluloses-based materials, and determination of structures and specifications
of new products produced as a result of
chemical transformation of these materials, and identification of places of use
of them, as well as analyses relating to
processes from cellulose production to
final area of use of paper, and structural analyses of woods and wood-based
materials, as a part of industrial services.
HPLC, UV-Vis spectrometer, GC-MS, Fourier
Transform Infrared Spectrometer (FT-IR), Viscosimeter, Rheometer, TMA, Universal tester (for paper products), Spectrophotometer (Elrepho), Glossy
paper coating device, Manual paper manufacturing
devices fit to various different standards.
We have collaborative studies and projects with Yıldız
Technical University (Turkey), Kastamonu University (Turkey), Gebze High Technology Institute (Turkey), Dokuz Eylül University (Turkey), İzmit Poplar
Industry Research Institute (Turkey), Western Michigan University (USA), and North Carolina University (USA), in addition to joint projects with private
sector entities, and TÜBİTAK (Scientific and Technological Research Council of Turkey) projects.
Prof. Dr. Celil Atik
+90 212 3382400 - 25375
[email protected]
101
FACULTY of FORESTRY
BASIN MANAGEMENT LABORATORY
I
t consists of two separate laboratories where water and soil analyses are
conducted. These laboratories offer
services on basin, hydrology, hydroecology, soil, etc. research by international
methods and through new generation
detailed analyses in line with needs and
demands of public and private sectors.
Kjeldahl semi-automatic nitrogen tester, Centrifuge, Turbidimeter, Ion-meter, Spectrophotometer,
pH-meter and EC-meter, Dissolved oxygen tester,
water turbidity meter, Soil moisture tester, Permeability device, Penetrometer, Lysimeter.
We have collaborative studies and pending projects
with Massachusetts University (USA), Department
102
of Agriculture, South Research Station (USA),
Çankırı Karatekin University, Süleyman Demirel
University (Turkey) and Forestry Research Institutes,
focused on basin management, semi-arid areas as a
part of climatic changes, pasture improvement.
Prof. Dr. Kamil Şengönül
+90 212 3382400 - 25338
[email protected]
FACULTY of AQUACULTURE
INSTRUMENTAL ANALYSIS LABORATORY
I
t deals with quality control, hygiene
and sanitation of aquacultural products from fishing to consumption,
and aquacultural toxicology, food safety
and product development. This laboratory conducts analyses for determination of fatty acid, amino acid, trimethylamine nitrogen and thiobarbituric acid
indices, and quantification of 4-hexylresorcinol and biogenic amine, and color
measurement and texture measurement analysis in aquacultural products.
Gas chromatography, High pressure liquid chromatography, UV-Vis spectrometer, Ultrasonic water
bath, Texture measurement device, Color measurement device, Frigorific centrifuge.
As a part of TÜBİTAK (Scientific and Technological Research Council of Turkey) supported and other internationally funded projects, various projects
focused on protection of aquacultural products and
prolongation of their shelf lives have been completed, and a European Union project is continuing for
formation of monitoring systems for food safety in
aquaculture.
Prof. Dr. Özkan Özden
+90 212 4555700 - 16440
[email protected]
103
FACULTY of AQUACULTURE
ECOTOXICOLOGY and CYANOTOXIN LABORATORY
A
ccumulation of cyanotoxins produced by cyanobacteria in aquatic biota, and determination of
genes producing cyanotoxins, and effects of environmental factors on cyanotoxin production, and accumulation
and convection of heavy metals in food
chain, and lethal dose studies for organism groups, and pesticide accumulation in living creatures and water, and
PAH analyses are conducted.
HPLC, ICP-MS, GS-MS, Real time PCR, Imaging
device, Freeze dryer, Cyanobacteria cultivation room,
TOC-meter, Laminar flow cabin, Ultrasonicator,
Spectrophotometer, Filtration system and microscopes.
Three European Union projects are continuing on
examination of cyanotoxins in our internal waters
104
and seas, and determination of their effects.
Assoc. Prof. Dr. Reyhan
Akçaalan Albay
+90 212 4555700 - 16453
[email protected]
TECHNOLOGY TRANSFER APPLICATION AND RESEARCH CENTER
CENTRAL RESEARCH LABORATORY (MERLAB)
I
t is founded for analyses in line with demands
of both Istanbul University organization units
and other public and private entities. Clarification of composition of organic ingredients (synthetic organic ingredients, natural organic ingredients, organometric ingredients, organic metal
complexes, polymers, etc.), trace element assays, identification of organic ingredients, determination of elemental percentages of solid or
liquid organic ingredients by combustion, qualitative and quantitative assay of inorganic complexes and organic ingredients, quantitative and
qualitative analyses of elements contained in
solid, powder and liquid samples, examination
of single crystalline – powder crystalline structures, molecule structures and molecule modeling of small molecules, and qualitative mineral analyses.
cm-1, with ATR unit)
• X-Ray Powder Crystal Diffraction (Rigaku D,
with high temperature oven unit, Cu source, and
graphite monochromator)
• X-Ray Single Crystal Diffractometer (Rigaku
R-Axis Rapid-S)
• X-Ray Fluorescence Spectrometer
• Liquid Chromatography – Mass Spectrometer
• Gas Chromatography (Thermo Finnigan Trace
GC Ultra) – Mass Spectrometer (Thermo Finnigan
Trace DSQ)
• Mass Spectrometer (Thermo Finnigan Trace
LCQ)
• Ultraviolet Visible Spectrometer (190 – 600 nm)
• Atomic Absorption Spectrophotometer (Analyst
200 flame, Analyst 600 Graphite oven and Perkin
• Nuclear Magnetic Resonance Spectrometer (Var-
Elmer Hydride Systems).
ian UNITY INOVA 500 MHz, 1D and 2D NMR,
APT, DEPT)
• Elemental Analyzer (Thermo Finnigan Flash EA
1112 Series)
• Inductive Coupling Plasma – Mass Spectrometer
(Thermo Elemental X Series 2)
• FT-IR Spectrometer (Perkin Elmer, 450 - 4000
Contemporary method studies are continuing
on X-ray diffraction with Max Planck Institute
(Germany) and Rikagu/MSC Woodland Texas
Laboratory (USA). In addition, contemporary
NMR and Elemental Analysis method studies
are carried out with Varian Application Laboratory (Germany).
Assoc. Prof. Dr. Hasret
Demircan Yardibi
+90 212 4400000 - 17772
[email protected]
105
SOCIAL SCIENCES
RESEARCH
LABORATORIES
FACULTY of COMMUNICATION
PRODUCTION and POST-PRODUCTION LABORATORY
T
108
his laboratory owns all generally
accepted professional software
programs used for editing, compositing and color grading works for digital videos. It is composed of 6 rooms,
four of which are offline editing rooms,
one is sound recording room, and one
is “Da Vinci Resolve” room used for final mixing. The laboratory has a world
standard infrastructure for work flow
after a healthy and reliable shooting. It
is technically satisfactory, reassuring,
quick and creative for users.
CMS 65 Reference Monitors, ART TPS II – Microphone Preamp.
Montage, cutting, color arrangement and sound mix
of short documentary film named Kamilet - 2014
Trento Mountain Films Festival (Italy); montage,
cutting, color arrangement and sound mix of medium-length documentary film named Antigoni – Finalist in 2013 Antalya Film Festival; vocal records
and mix of new album of famous Rock musician
named Umut Kaya; Nursing Faculty Skill Videos; montage and cutting of around 200 skill videos
sponsored by Florence Nightingale Foundation; and
Tangent Device - DA VINCI Control Interface,
montage and cutting of “Democracy” project spon-
LYNX HILO - Analog Digital, Digital Analog Sound
sored by YEKÜV and handled by a project of Istan-
Converter, BON 24 inch Grade 1 Monitor, MAC
bul University Scientific Research Projects Unit.
OS Workstation-based montage and cutting system,
FCP X, AVID, ADOBE, DA VINCI, WINDOWS
Workstation-based montage and cutting system,
EDIUS and ADOSE, Main Storage Unit (50 TB),
SAS Storage Unit (16 TB), data speed above 1 GB
per second, Real Time H.264 Converter, FOCAL
Asst. Prof. Dr. İlkay Nişancı
+90 212 4400000 - 12749
[email protected]
FACULTY of LETTERS
PREHISTORY LABORATORY
E
arthenware, stones, bones and clay
findings of different regions and periods are examined and analyzed in
typological, technological and functional terms. This laboratory has the most
comprehensive archaeological materials archive of Turkey. The archaeological archive, standing as a reference catalogue, contains materials coming from
1645 mounds, ruins and sites, and systematic – layered – samples of around
one hundred archaeological sites, and
material samples of prehistoric cultures
of Near East and Balkans, and West European Paleolithic Era finds, and material samples coming from all obsidian
sources in Turkey, Aegean and Mediterranean regions.
Connecticut University (USA), Arizona University (USA), Cornell University (USA), Paris University (France), National Natural History Museum
(France), National France Scientific Research Center
(France), Lyon University (France), Eberhard Karls
Tubingen University (Germany), Ludwig-Maximilian University (Germany), Munich Archaeology
Museum (Germany), German Archaeology Institute, Bergbau German Mining Museum (Germany),
Karlsruhe University (Germany), Cologne University (Germany), Austrian Science Academy (Austria),
Vienna University (Austria), New Bulgarian University (Bulgaria), Sozopol Underwater Archaeology
Center (Bulgaria), Czech Republic Science Academy
(Czech Republic), Prague University (Czech Republic), Natural History Museum (United Kingdom),
Groningen University (Netherlands), Athens Clas-
sical Studies American School (Greece), Istanbul
Technical University (Turkey), Hacettepe Universi-
Multi-enlargement metallurgic microscopes, Stereo
ty (Turkey), Koç University (Turkey) and Eskişehir
microscopes.
Anatolian University (Turkey).
Asst. Prof. Dr. Eylem Özdoğan
+90 212 4555700 - 15825
[email protected]
109
FACULTY of LETTERS
SHIP CONSERVATION and RECONSTRUCTION LABORATORY
V
arious chemical experiments that
may be needed in mortar and
plaster analyses, ship models,
conservation and restoration works are
conducted. Underwater artworks are
subject to conservation and restoration
works.
Heating system stainless steel PEG impregnating
tank, Fume hoods, Drying oven, Microscopes and
ship modeling tools.
We conduct joint projects with Byzantine and
Post-Byzantine
Monuments
Research
Center
(Greece) and Presidency of the Republic of Turkey.
110
Research Assistant Taner Güler
+90 212 4555700 - 16017
[email protected]
FACULTY of LETTERS
YENİKAPI SUNKEN WRECKS RESEARCH CENTER LABORATORY
C
onservation, restoration, three dimensional drawing, photographing and photomosaic works of
sunken ships are performed.
FaroArm 3D digitizer, Photograph mechanism with
paraflash system, Water purification system, Largescale oven and freeze dryer.
We conduct joint projects with Byzantine and
Post-Byzantine
Monuments
Research
Center
(Greece) and Presidency of the Republic of Turkey
and Roskilde Museum (Denmark).
111
Research Assistant Namık
Kılıç
+90 212 5880100
[email protected]

University Research Laboratories

Transcription

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