Folie 1 - melodi

Realizing the European Network
of Biodosimety
Ulrike Kulka on behalf of the RENEB consortium
Federal Office for Radiation Protection
Oberschleissheim, Germany
EU-Project
Seventh Framework Programme (FP7) of the European Atomic Energy
Community (Euratom)
Project type:
Networking and coordination in biodosimetry
(Coordination Action)
Project acronym: RENEB
Project full title:
„Realising the European Network of Biodosimetry“
Duration:
01.01.2012 – 31.12.15
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
Realising the European Network of Biodosimetry
BfS
BIR/UULM
CEA
ENEA
HMGU
PHE
ICHTJ
INSP
IRSN
ISS
ITN
LAFE
LUMC
NCRRP
NCSR D
NRIRR
NRPA
STUK
SU
UAB
UGent
UNITUS
SERMAS
Bundesamt für Strahlenschutz
Bundeswehr Institut für Radiobiologie/Universität Ulm
Commissariat à l´Énergie Atomique
Agenzia Nazionale per le Nuove Tecnologie L´Energia
Helmholtz Centre Munich
Public Health England
Institut Chemii i Techniki Jadrowej
Institutul National de Sanatate Publica
Institut de Radioprotection et de Sûreté Nucléaire
Instituto Superiore di Sanità
Instituto Tecnológico e Nuclear
Fundacion para la Investigation del Hospital Univ. la fe Com. Valenciana
Leiden University Medical Center
National Center for Radiobiology and Radiation Protection
National Centre for Scientific Research “Demokritos”
National Research Institute for Radiobiology & Radiohygiene
Norwegian Radiation Protection Authority
Radiation and Nuclear Safety Authority
Stockholm University
Universitat Autonoma de Barcelona
Universiteit Gent
University of Tuscia
Servicio Madrileño de Salud -,Hospital General Universitario G. Marañón
5th MELODI Workshop, Brussels, October 10, 2013
Germany
Germany
France
Italy
Germany
United Kingdom
Poland
Romania
France
Italy
Portugal
Spain
The Netherlands
Bulgaria
Greece
Hungary
Norway
Finland
Sweden
Spain
Belgium
Italy
Spain
GA No. 295513
Outline
RENEB
 Background
 Objective
 Key aspects
and
possible contribution to radiation research
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
Background
 Why do we need biological dosimetry ?
 Increasing likelihood for accidents in nuclear facilities and
potential terrorist attacks against key facilities or civil targets
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
Realising the European Network of Biodosimetry
 Strategies to handle large-scale radiological scenarios
 Automation of processing biological material
 Automation of analysis
 Fully automated scanning
 Computer assisted scoring
 Fully automated scoring
 Scoring strategy
 Scoring in triage mode
 Web based scoring
 Networking
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Objective
RENEB will establish a sustainable European network
in biological dosimetry
 mutual assistance in a large scale radiological incidence
 to guarantee the highest efficiency in the processing and
scoring of biological samples
 for fast and reliable results in dose estimation
 implemented in national and international emergency
management.
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Objective
RENEB will establish a sustainable European network
in biological dosimetry
 mutual assistence in a large scale radiological incidence
 to guarantee the highest efficiency in the processing and
scoring of biological samples
 for fast and reliable results in dose estimation
 implemented in national and international emergency
management.
Needs in large scale studies
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Key aspects
RENEB focusses on 5 topics:
 Operational basis of the network
 Education, Training and Quality assurance (E&T, QA&QM)
 Development of the network
 Long term sustainability of the network
 Dissemination
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Operational Basis
“Stand by mode” of reliable and proven methods
 Dicentric Assay
 Fluorescence in situ hybridisation (FISH-Assay)
 Micronucleus assay
 Premature Chromosome Condensation (PCC)
 Gamma H2AX Foci
 Electron Paramagnetic Resonance/
Optically Stimulated Luminescence Electro
nic
(EPR/OSL) on mobile phone
compo-
Glass
nents
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Operational Basis
“Stand by mode” of reliable and proven methods
 Dicentric Assay
 Fluorescence in situ hybridisation (FISH-Assay)
 Micronucleus assay
 Premature Chromosome Condensation (PCC)
 Gamma H2AX Foci
 Electron Paramagnetic
Used inResonance/
research studies
Optically Stimulated Luminescence
(EPR/OSL) on mobile phone
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Operational Basis
Harmonisation of the protocols
 Image analysis
 Intercomparisons
 Emergency exersise
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Operational Basis
Harmonisation
 Image analysis
 “Telescoring”
 Aberration scoring
 Dose estimation
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Operational Basis
Harmonisation
 Image analysis
 Intercomparisons
 shipment
 culturing
 preparation and staining
 scoring
 dose estimation
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Operational Basis
Harmonisation
 Image analysis
 Intercomparisons
Intercomparisons performed in 2013:
Dic assay:
Fish assay :
Micronucleus assay:
gamma H2AX assay:
PCC assay:
EPR:
OSL:
19 labs
11 labs
12 labs
12 labs
5 labs
11 labs
12 labs
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Education & Training and QA & QM
Assurance of efficient and reliable dose estimation by
 Harmonisation of biodosimetry procedures
 Establishing an education & training program
for members and non-members
 Setting up a quality assurance & management program
(QA & QM)
 Development of a long-term training program based on
regular training exercises according to international
standards including intercomparisons
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Education & Training and QA & QM
Assurance of efficient and reliable dose estimation by
 Harmonisation of biodosimetry procedures
 Establishing an education & training program
for members and non-members
 Setting up a quality assurance & management program
(QA & QM)
 Development of a long-term training program based on
regular training exercises according to international
standards including intercomparisons
Contribution to research studies
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Education & Training and QA & QM
 Activities in 2012/13
Competence level of members:
 questionnaire
 quality exercise (image analysis)
 Intercomparisons
 practical training in partner laboratories has started
 seminars have started: e.g. „Quality and Statistics“:
Presentation of ISO documents, statistics applied to biological
dosimetry, example of lab practicing, practical exercises
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Development of the network
Horizon scanning for new techniques and partners
 Identification, validation and inclusion of new assays
Reporting sheet on the website (www.reneb.eu)
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Development of the network
Horizon scanning for new techniques and partners
 Identification, validation and inclusion of new assays
Reporting sheet on the website (www.reneb.eu)
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Sustainability of the Network
Assurance of legal certainty and
establishing links with existing platforms:
 Harmonisation of communication structure
 Long term commitment of national decision makers and
agencies
 Establishing a legal framework
 Linking RENEB to research-, infrastructure- and E&T platforms
(e.g. EURADOS, MELODI) and RTD projects (DoReMi, NERIS-TP)
Action during the „silent period“
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Sustainability of the Network
Assurance of legal certainty and
establishing links with existing platforms:
 Harmonisation of communication
 Long term commitment of national decision makers and
agencies
 Establishing a legal framework
 Linking RENEB to research-, infrastructure- and E&T platforms
(e.g. EURADOS, MELODI) and RTD projects (DoReMi, NERIS-TP)
Action during the „silent period“
Contribution to research, E&T, QA
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Dissemination
Strengthening the awareness of RENEB:
 Connecting RENEB to the European and international
radiation emergency preparedness and
response system
(WHO BioDoseNet, IAEA RANET)
 Spreading the information about RENEB
bulletin
open website: www.reneb.eu
show case workshop (2015)
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
 Dissemination
Strengthening the awareness of RENEB:
 Connecting RENEB to the European and international
radiation emergency preparedness and
response system
(WHO BioDoseNet, IAEA RANET)
 Spreading the information about RENEB
bulletin
open website: www.reneb.eu
show case workshop
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
Advisory Board:
RENEB Consortium:
Elena Buglova, IAEA
Zhanat Carr, WHO
David Lloyd, former HPA
Istvan Turai, EC/ENER Radiation
Protection, Luxembourg
Bundesamt für Strahlenschutz, Germany: H. Romm, U. Oestreicher, U. Kulka
Bundeswehr Institut für Radiobiologie / Universität Ulm, Germany: C. Beinke
Public Health England, United Kingdom: L. Ainsbury , J. Moquet, K. Rothkamm
Helmholtz Centre Munich, Germany: M. Atkinson, S. Mörtl, A. Wieser, C. Woda
Institut de Radioprotection et de Sûreté Nucléaire, France: J.Barquinero4, C. Bassinet, E. Gregoire, S. Roch-Lefevre, F. Trompier, P. Voisin
Universitat Autonoma de Barcelona, Spain: L. Barrios
National Research Institute for Radiobiology & Radiohygiene , Hungary: I. Turai, E. Kis, Katalyn
Institutul National de Sanatate Publica, Romania: A. Cucu, I. Popescu, M. Noditi
Leiden University Medical Center , The Netherlands: F. Darroudi
Istituto Superiore di Sanità, Italy: P. Fattibene
Instituto Tecnológico e Nuclear, Instituto Superior Técnico, Universidade Técnica de Lisboa: O. Gil, P. Vaz
 National Center for Radiobiology and Radiation Protection, Bulgaria: V. Hadjidekova
 Stockholm University, Sweden: A. Wojcik, S. Haghdoost
 Servicio Madrileño de Salud - Hospital General Universitario Gregorio Marañón, Spain: R. Herranz, M. Moreno, M.J Prieto
Norwegian Radiation Protection Authority, Norway: A. Jaworska, F. Ugletveit
Radiation and Nuclear Safety Authority, Finland: C. Lindholm
 Commissariat à l´Énergie Atomique, France: W. Hempl, R. Mkacher, A. Obazghi , L. Sabatier
Fundacion para la Investigation del Hospital Universitario la Fe de la Comunidad Valenciana, Spain: A. Montoro, N. Fabregat
 University of Tuscia, Italy: F. Palitti
 National Centre for Scientific Research Demokritos, Greece: G. Pantelias , G. Terzoudi
 Institut Chemii i Techniki Jadrowej, Poland: S. Sommer
 Agenzia Nazionale per le Nuove Tecnologie, L´Energia e lo Sviluppo Economico Sostenibile, Italy: A. Testa
 Universiteit Gent , Belgium: H. Thierens, A. Vral
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513
Advisory Board:
RENEB Consortium:
Elena Buglova, IAEA
Zhanat Carr, WHO
David Lloyd, former HPA
Istvan Turai, EC/ENER Radiation
Protection, Luxembourg
Bundesamt für Strahlenschutz, Germany: H. Romm, U. Oestreicher, U. Kulka
Bundeswehr Institut für Radiobiologie / Universität Ulm, Germany: C. Beinke
Public Health England, United Kingdom: L. Ainsbury , J. Moquet, K. Rothkamm
Helmholtz Centre Munich, Germany: M. Atkinson, S. Mörtl, A. Wieser, C. Woda
Institut de Radioprotection et de Sûreté Nucléaire, France: J.Barquinero4, C. Bassinet, E. Gregoire, S. Roch-Lefevre, F. Trompier, P. Voisin
Universitat Autonoma de Barcelona, Spain: L. Barrios
National Research Institute for Radiobiology & Radiohygiene , Hungary: I. Turai, E. Kis, Katalyn
Institutul National de Sanatate Publica, Romania: A. Cucu, I. Popescu, M. Noditi
Leiden University Medical Center , The Netherlands: F. Darroudi
Istituto Superiore di Sanità, Italy: P. Fattibene
Instituto Tecnológico e Nuclear, Instituto Superior Técnico, Universidade Técnica de Lisboa: O. Gil, P. Vaz
 National Center for Radiobiology and Radiation Protection, Bulgaria: V. Hadjidekova
 Stockholm University, Sweden: A. Wojcik, S. Haghdoost
 Servicio Madrileño de Salud - Hospital General Universitario Gregorio Marañón, Spain: R. Herranz, M. Moreno, M.J Prieto
Norwegian Radiation Protection Authority, Norway: A. Jaworska, F. Ugletveit
Radiation and Nuclear Safety Authority, Finland: C. Lindholm
 Commissariat à l´Énergie Atomique, France: W. Hempl, R. Mkacher, A. Obazghi , L. Sabatier
Fundacion para la Investigation del Hospital Universitario la Fe de la Comunidad Valenciana, Spain: A. Montoro, N. Fabregat
 University of Tuscia, Italy: F. Palitti
 National Centre for Scientific Research Demokritos, Greece: G. Pantelias , G. Terzoudi
 Institut Chemii i Techniki Jadrowej, Poland: S. Sommer
 Agenzia Nazionale per le Nuove Tecnologie, L´Energia e lo Sviluppo Economico Sostenibile, Italy: A. Testa
 Universiteit Gent , Belgium: H. Thierens, A. Vral
Thank you for your attention
5th MELODI Workshop, Brussels, October 10, 2013
GA No. 295513