pharmax trans-dermal pain management creams

Where Nutritional Science Comes to Life.
PHARMAX TRANS-DERMAL
PAIN MANAGEMENT
CREAMS
REVOLUTIONARY SCIENCE
FOR IMPROVED PATIENT RELIEF
NEW
NOW AVAILABLE
New formats
and pack sizes
THE EVOLUTION OF TRANS-DERMAL
TECHNOLOGY
THE DELIVRA™ DIFFERENCE
Delivra, a proprietary compound base topical delivery system, combines
medicinal ingredients that deeply penetrate into the skin to target affected
areas. This new pharma-based technology developed by leading Canadian
Molecular Pharmacologist, Dr. Joseph Gabriele, draws on interactions
between plant-product substances, human cellular and nerve tissues.
Gabriele’s objective was to develop a new method to pain relief as an
alternate to oral medications, and with the Delivra technology combining
premium grade active ingredients that penetrate deep into the dermis
layer; this revolutionary technology is shaping the way healthcare
practitioners think about topical pain relief.
2
Joseph Gabriele PhD
Joseph Gabriele PhD,
is a Molecular
Pharmacologist
specializing in the field
of signal transduction
pathways in numerous
disease states.
His early experience
focused on Psychiatry
and Behavioural Neurosciences as a
research scientist at McMaster University in
Hamilton, Ontario.
In 1981 Dr. Gabriele received his B.Sc.
degree from the University of Toronto
and in 2003 was awarded his Masters of
Science and PhD degrees from McMaster
University. In 2006, Dr. Gabriele received
his postdoctoral training on the molecular
pharmacological effects of antipsychotic
medications in patients with schizophrenia
at Queens University, Kingston, Ontario.
Dr. Gabriele lectures across North America
on molecular pharmacology, specifically,
molecular pathways that are affected by
pharmacological and natural molecules.
His research discovered a revolutionary new
technology for the trans-dermal delivery of
a natural medication that has the potential
to block 5 main pain pathways. A recent
double-blind crossover clinical trial has
proven both compelling and remarkable;
clearly showing significant pain relief at
the local level without the use of synthetic
pharmacological drugs and avoiding adverse
side effects such as gastrointestinal and
cardiovascular complications.
Dr. Gabriele continues his solid commitment
to research in collaboration with an
extensive research team developing this
unique technology, providing physicians and
healthcare practitioners with a powerful
tool to deliver medications and natural
molecules to the body.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, prevent any disease.
The aim of this comprehensive product guide is to assist in building more effective and successful patient treatment strategies. The product guide is to be used as an adjunct to Seroyal Continuing
Medical Education and is not intended to be utilized as a diagnostic tool nor replace any other required education. The remedies indicated in this product guide are potent medicines that
can have profound therapeutic effects on patients. As with any intervention, the dosage may need to be adjusted for those with chronic conditions, very sensitive individuals and those taking
multiple medications. Practitioners are solely responsible for the care and treatment provided to their own patients. The information provided by the speaker or speakers in the Seroyal Continuing
Medical Education program together with any written material provided do not necessarily represent the views of Seroyal and are not intended as medical advice or an endorsement of any
products. This information is for practitioner use only and is not meant to diagnose, treat, cure, prevent any disease or replace traditional treatment, and has not been evaluated by the FDA.
Copyright © 2014 Seroyal. All rights reserved. No part of this information may be used or reproduced in any form or by any means, or stored in a database or retrieval system, or be distributed or
replicated without express permission of Seroyal. Making copies of any part of this information for any purposes other than your own personal use is a violation of copyright law.
2327. Version 6.
THE EVOLUTION OF PAIN MANAGEMENT
6X STRONGER THAN COMPETITIVE TRANSPORT TECHNOLOGY
Delivery Depth of Naproxen
Delivra™ vs Competitor
80,000
73,500
At 24 hours,
concentration
of Delivra™ is
DELIVRA™
COMPETITOR
10,700
10,000
CONCENTRATION (NG/ML)
The Subdermal Trials – The Delivra™ base
underwent rigorous testing for its depth of
penetration as a trans-dermal carrier cream.*
The base was mixed with Naproxen (the active
ingredient in Aleve®, a drug used for pain
relief) and tested for the depth of its reach
under the many skin layers and into the active
dermis layer. Delivery depth of Naproxen with
Delivra compound in comparison to the leading
competitor showed a greater pharmaceutical
delivery depth of Naproxen to the underlying
dermis layer. Delivra™ outperformed the
competitor 6.8 to 1.
* In vitro studies using reconstructed epidermis Epiderm™
687% HIGHER
4,000
3,500
3,385
3,000
At 6 hours,
concentration
of Delivra™ is
123% HIGHER
2,760
2,500
2,000
At 3 hours,
concentration
of Delivra™ is
1,740
1,500
253% HIGHER
1,000
500
503
688
169
0
1 HR
3 HRS
6 HRS
24 HRS
At 1 hour,
concentration
of Delivra™ is
297% HIGHER
CONCENTRATION OF NAPROXEN (TIMED INTERVALS)
FEATURE BENEFITS
PURIFIED NATURALS INHIBIT 5 PAIN PATHWAYS
• GMP/Protein Kinase G Pathway
• Protein Kinase C Pathway
• Nitric Oxide Pathway
• Histamine Pathway
• Arachidonic Pathway
DERIVED FROM PUREST NATURAL ACTIVES
An excellent alternative to wholly synthetic, emollient-based creams, Delivra delivers pure active
ingredients processed using CO2 extration and purified by High-Pressure Liquid Chromatography;
a technique that separates, identifies and quantifies each component in a mixture.
NON-GREASY & NON-STICKY FORMULA
Addition of amphiphilic molecules creates a smooth, silky topical cream that’s quickly absorbed
• Pleasant odor
• Paraben-free
• Doesn’t contain solium lauryl sulfate (SLS) or petrolatum
• Convenient airless pump extends shelf life and helps control consumption
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
3
ON THE GO?
Introducing Pharmax™ Nerve and
Pharmax™ Relief in convenient
compact snap packs.
NEW
The transformative and effective pain relief found in Pharmax™ Nerve and
Pharmax™ Relief are now available in a convenient new snap pack. Simply fold
and squeeze the snap pack to release the amount of cream you need. Whether you
release a little or a lot the sachet snaps back to its original shape, safely protecting
the remaining contents for next time. Its painless to find relief wherever you are.
4
A Trusted Seroyal Brand
1-888-737-6925
www.seroyal.com/pharmax
PHARMAX™ NERVE
PHARMAX™ RELIEF
Neuropathic pain relief
Joint pain relief
Temporary relief from symptoms associated with nerve
pain, diabetic nerve pain and shingles pain
Temporary relief of minor aches and pains associated
with simple backaches, sprains and arthritis
Natural oils and extracts include:
•Capsaicin fruit rich in vitamin A and contains vitamins B6, E, C,
riboflavin, potassium and manganese1
•Fenugreek seed assists in healing localized inflammation areas
•Rutin an antioxidant and skin-conditioning agent
•Acai fruit oil contains omega 3 fatty acids and antioxidants
•Green tea leaf extract contains polyphenols, catechins and tannins
•Lime oil regulates nerve channel
Natural oils and extracts include:
•Rutin antioxidant and skin-conditioning agent
•Black currant seed oil rich in gamma linoleic acid
•Raspberry seed oil includes omega-3 and omega-3 fatty acids
•Argan kernel oil highly concentrated natural tocopherols and essential
fatty acids
•Blue lotus flower extract, Masterwort leaf extract and European
elder extract are all rich in flavanoids
Now available in a compact snap pack! 2 pack sizes to
choose from.
Now available in a compact snap pack! 2 pack sizes to
choose from.
DRUG FACTS
Active ingredient Purpose
Capsicum (Capsicum annuum L.) 2C . . . . . . . . . . . . . Topical Analgesic
DRUG FACTS
Active ingredient Purpose
Rue (Ruta graveolens) 3X. . . . . . . . . . . . . . . . . . . . . . . . Topical Analgesic
Uses
Temporary relief from symptoms of n nerve pain n diabetic nerve pain
n shingles pain, as per Homeopathic Materia Medica.
Uses
For the temporary relief of minor aches and pains associated with simple
backaches, sprains and arthritis, as per Homeopathic Materia Medica.
Warnings
For external use only.
Do not use n on wounds or damaged skin n with a heating pad
When using this product n avoid contact with eyes or mucous membranes
n do not bandage tightly n use only as directed
Stop use and ask a doctor if n symptoms worsen n symptoms persist for
more than 7 days or clear up and occur again within a few days n excessive
skin irritation occurs
If pregnant or breastfeeding, ask a health professional before use.
Keep out of reach of children. If swallowed, get medical help or contact a
Poison Control Center right away.
Warnings
For external use only.
Do not use n on wounds or damaged skin n in large quantities, particularly
over raw surfaces or blistered areas n with a heating pad n if you are allergic
to the Astereae/ Compositae/Daisy family
When using this product n avoid contact with eyes or mucous membranes
n do not bandage tightly n use only as directed
Stop use and ask a doctor if n symptoms worsen n symptoms persist for
more than 7 days or clear up and occur again within a few days n excessive
skin irritation occurs
If pregnant or breastfeeding, ask a health professional before use.
Keep out of reach of children. If swallowed, get medical help or contact a
Poison Control Center right away.
Directions (bottle) n apply a small amount on the affected area 1 to
4 times daily or as recommended by a doctor n children (2 and under): consult
a doctor
Directions (snap pack) n apply 1.5 g to the affected area
n children (under 2 years of age): consult a doctor
Inactive ingredients
Beeswax, camellia sinensis leaf extract, cetearyl olivate, chlorphenesin,citrus
aurantifolia (lime) oil, dromiceius oil, euterpe oleracea fruit oil, glycerin, isopropyl
palmitate, leptospermum scoparium oil, peucedanum ostruthium leaf extract,
polyacrylate-13, polyisobutene, polysorbate 20, angelica root oil, potassium
citrate, purified water, rutin, sambucus nigra flower extract, sodium phytate,
sorbitan olivate, xanthan gum
Pack Size
2.5 oz (70 g) Cream NEW 14 x 0.05 oz (1.5 g) Snap Pack
NEW 50 x 0.05 oz (1.5 g) Snap Pack
Product Code
TP01-70
TP01-14SACH
TP01-50SACH
Directions (bottle) n adults and children (2 years and older): apply a small
amount on the affected area 1 to 4 times daily or as recommended by a doctor
n children (under 2 years of age): consult a doctor
Directions (snap pack) n apply 1.5 g to the affected area
n children (under 2 years of age): consult a doctor
Inactive ingredients
Argania spinosa kernel oil, beeswax, benzoic acid, calendula officinalis flower
extract, cetearyl olivate, dehydroacetic acid, dromiceius oil, ethoxydiglycol,
glycerin, isopropyl palmitate, melaleuca alternifolia (tea tree) leaf oil, nymphaea
caerulea flower extract, peucedanum osthruthium leaf extract, potassium
citrate, purified water, ribes nigrum (black currant) seed oil, rubus idaeus
(raspberry) seed oil, sambucus nigra flower extract, sodium hydroxide, sodium
phytate, sorbitan olivate, xanthan gum
Pack size
2.5 oz (70 g) Cream NEW 14 x 0.05 oz (1.5 g) Snap Pack
NEW 50 0.05 oz (1.5 g) Snap Pack
Product Code
TP02-70
TP02-14SACH
TP02-50SACH
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
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NEW PHARMAX™ REBUILD
Muscle and joint pain relief cream
NEW PHARMAX™ FIBRO
Muscle pain and fatigue
relief cream
NEW PHARMAX™ VARICOSE
Varicose vein relief cream
Temporarily relieves symptoms of
arthritis including aching, soreness and
minor pain
Temporarily relieves symptoms of
rheumatism including muscle and joint
weakness, stiffness and fatigue
Temporarily relieves symptoms
associated with varicose veins including
stinging, prickling and bruised soreness
Natural oils and extracts include:
•Rutin an antioxidant and skin-conditioning agent
•Arnica flower helps with bruises, injuries of the
joints and rheumatism2,3
•Phytosterols promotes protection of skin
barrier function, epidermis repair and improving
collagen synthesis
•Glucosamine hydrochloride amino sugar and
precursor to assist in the synthesis of proteins
and lipids
•Pomegranate pericarp extract an antioxidant
and skin-conditioning agent
Natural oils and extracts includes:
•Capsaicin fruit rich in vitamin A and contains
vitamins B6, E, C, riboflavin, potassium and
manganese4
•Creatine skin conditioning agent naturally
produced in the body from amino acids and
assists in energy production of cells
•D-Ribose a pentose sugar that assists in
cellular energy production
•Pomegranate pericarp extract a skin conditioning
agent comprised of fatty acids and flavonols
Natural oils and extracts include:
•Witch Hazel bark used for venous congestion
and varicose veins5, 6
•Horse Chestnut seed extract a skin
conditioning agent containing anti-inflammatory
and antioxidant compounds7
•Rutin an antioxidant and skin-conditioning agent
DRUG FACTS
Active ingredient Purpose
Arnica montana L. 5C HPUS. . . . . . . Topical Analgesic
The letters “HPUS” indicate that the component
in this product is officially monographed in the
Homoeopathic Pharmacopoeia of the United States.
Uses Temporarily relieves symptoms of arthritis
including aching, soreness and minor pain, as per
Homeopathic Materia Medica.
Warnings
For external use only.
Do not use n on wounds or damaged skin
n with a heating pad n if you are allergic to plants of
the Asteraceae/Compositae/Daisy family
When using this product n avoid contact with
eyes or mucous membranes n do not bandage tightly
n use only as directed
Stop use and ask a doctor if n symptoms worsen
n symptoms persist for more than 7 days or clear up
and occur again within a few days n excessive skin
irritation occurs
If pregnant or breastfeeding, ask a health
professional before use.
Keep out of reach of children. If swallowed, get
medical help or contact a Poison Control Center right
away.
Directions n apply 2 pumps (0.08 oz) to the
affected area two times daily or as recommended by
a doctor n children (2 years and under): consult a
doctor
Inactive ingredients Butylene Glycol, Carthamus
Tinctorius (Safflower) Oleosomes, Cetearyl Olivate,
Cetyl Palmitate, Chlorphenesin, Dimethyl Isosorbide,
Ethoxydiglycol, Ethylhexylglycerin, Glucosamine
HCl, Glycerin, Lecithin, Phytosterols, Propylheptyl
Caprylate, Punica Granatum Pericarp Extract, Rhus
Verniciflua Peel Wax, Ribes Nigrum (Black Currant)
Seed Oil, Rutin, Sambucus Nigra Flower Extract,
Sodium Citrate, Sodium Stearoyl Glutamate, Sorbitan
Olivate, Sorbitan Palmitate, Water, Xanthan Gum
Pack Size
2.5 oz (70 g) Cream Product Code
TP04H-70
DRUG FACTS
Active ingredient Purpose
Capsicum annuum L. 5C HPUS. . . . Topical Analgesic
Kali phosphoricum 8X HPUS. . . . . . . Topical Analgesic
Phosphorus 8X HPUS. . . . . . . . . . . . . Topical Analgesic
The letters “HPUS” indicate that the component
in this product is officially monographed in the
Homoeopathic Pharmacopoeia of the United States.
Uses Temporarily relieves symptoms of rheumatism
including muscle and joint weakness, stiffness and
fatigue, as per Homeopathic Materia Medica.
Warnings
For external use only.
Do not use n on wounds or damaged skin
n with a heating pad
When using this product n avoid contact with eyes or
mucous membranes n do not bandage tightly n use only
as directed n transient skin irritation, burning, stinging
or redness are part of the normal, expected actions and
usually diminish after repeated application
Stop use and ask a doctor if n symptoms worsen
n symptoms persist for more than 7 days or clear up
and occur again within a few days
n excessive skin irritation occurs
If pregnant or breastfeeding, ask a health
professional before use.
Keep out of reach of children. If swallowed, get
medical help or contact a Poison Control Center right
away.
Directions n apply 2 pumps (0.08 oz) to the affected
area four times daily or as recommended by a doctor
n children (2 years and under): consult a doctor
Inactive ingredients Butylene Glycol, Caprylyl
Glycol, Capsicum Frutescens Fruit Extract, Cetearyl
Olivate, Cetyl Palmitate, Chlorphenesin, Copernicia
Cerifera (Carnauba) Wax, Creatine, Emu Oil,
Ethoxydiglycol, Glycerin, Helianthus Annuus (Sunflower)
Seed Oil, Inulin Lauryl Carbamate, Isopropyl Palmitate,
Lecithin, Leptospermum Scoparium Branch/Leaf Oil,
1-Methylhydantoin-2-Imide, Peucedanum Ostruthium
Leaf Extract, Potassium Citrate, Punica Granatum
Pericarp Extract, Ribes Nigrum (Black Currant) Seed Oil,
Ribose, Rutin, Sambucus Nigra Flower Extract, Sorbitan
Olivate, Sorbitan Palmitate, Water, Xanthan Gum
Pack Size
2.5 oz (70 g) Cream 6
DRUG FACTS
Active ingredient Purpose
Hamamelis virginiana L. 5C . . . . Topical Astringent
HPUS
The letters “HPUS” indicate that the component
in this product is officially monographed in the
Homoeopathic Pharmacopoeia of the United States.
Uses Temporarily relieves symptoms associated with
varicose veins including stinging, prickling and bruised
soreness, as per Homeopathic Materia Medica.
Warnings
For external use only.
Do not use n on wounds or damaged skin
n with a heating pad
When using this product n avoid contact with eyes or
mucous membranes n do not bandage tightly n use only
as directed n in rare cases some people may experience
a skin rash
Stop use and ask a doctor if n symptoms worsen
n symptoms persist for more than 7 days or clear up
and occur again within a few days n excessive skin
irritation occurs
If pregnant or breastfeeding, ask a health
professional before use.
Keep out of reach of children. If swallowed, get
medical help or contact a Poison Control Center right
away.
Directions n apply 1 pump (0.04 oz) to the affected
area once daily or as recommended by a doctor
n children (2 years and under): consult a doctor
Inactive ingredients Aesculus Hippocastanum
(Horse Chestnut) Seed Extract, Arnica Montana
Flower Extract, Butylene Glycol, Cetearyl Olivate, Cetyl
Palmitate, Chlorphenesin, Citrus Aurantifolia (Lime) Oil,
Citrus Limon (Lemon) Fruit Extract, Copernicia Cerifera
(Carnauba) Wax, Dicaprylyl Carbonate, Ethoxydiglycol,
Glycerin, Lecithin, Peucedanum Ostruthium Leaf Extract,
Polyacrylate-13, Polyisobutene, Polysorbate 20,
Ribes Nigrum (Black Currant) Seed Oil, Rosmarinus
Officinalis (Rosemary) Leaf Extract, Rubus Idaeus
(Raspberry) Seed Oil, Ruscus Aculeatus Root Extract,
Rutin, Sambucus Nigra Flower Extract, Sodium Phytate,
Solidago Virgaurea (Goldenrod) Extract, Sorbitan
Olivate, Sorbitan Palmitate, Water, Xanthan Gum
Pack size
2.5 oz (70 g) Cream Product Code
TP05H-70
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Product Code
TP06H-70
PHARMAX™ HEAL
Wound healing cream
NEW PHARMAX™
COMPOUND BASE
Premium trans-dermal
delivery system
For the relief of wounds, cuts, scrapes,
abrasions, minor burns and sunburns
Natural oils and extracts include:
•Calendula flower extract promotes healthy
granulations and rapid healing8
•Rutin an antioxidant and skin-conditioning agent
•Manuka branch/leaf oil appears to involve a
post-synaptic spasmolytic effect
•Sea buckthorn seed oil rich in linoleic and
linolenic acid
•Red alga extract contains copper sulphate
DRUG FACTS
Active ingredient Purpose
Calendula (Calendula officinalis L.) 3C. . . . . . Antiseptic
Uses Topical relief for n wounds n cuts, scrapes
and abrasions n minor burns and sunburns, as per
Homeopathic Materia Medica.
Warnings
For external use only.
Do not use n in eyes n over large areas of body
n longer than one week, unless directed by
a doctor n if you are allergic to the Astereae/
Compositae/Daisy family
Ask a doctor before use if you have deep or
puncture wounds, animal bites or serious burns.
Stop use and ask a doctor if n symptoms persist
or worsen n a rash or other irritation develops
If pregnant or breastfeeding, ask a health
professional before use.
Keep out of reach of children. If swallowed, get
medical help or contact a Poison Control Center right
away.
Directions n clean the affected area n apply a small
amount on the affected area 1 to 3 times daily or as
recommended by a doctor n may be covered with a
bandage
Inactive ingredients Argania spinosa kernel oil,
betula alba bark extract, cetearyl olivate, chlorphenesin,
citric acid, copernicia cerifera (carnauba) wax,
dromiceius oil, ethoxydiglycol, ethylhexylglycerin,
glycerin, hippophae rhamnoides oil, isopropyl palmitate,
leptospermum scoparium oil, porphyridium cruentum
extract, potassium citrate, purified water, rutin, sambucus
nigra flower extract, scrophularia nodosa extract, sodium
hydroxide, sodium phytate, sorbitan olivate, xanthan gum
Pack Size
2.5 oz (70 g) Cream Oil & water micelle formulation
•Penetrates deep into the dermis layer
Compound base includes
•Polyphenols, rutin and its derivatives
Compounding Instructions:
For healthcare practitioners only. For compounding
purposes only. Responsibility for safety, efficacy
and quality of the compounded product is assumed
by the healthcare practitioner. Base not for resale.
Any blend intended for resale must be repackaged
into separate container. Utilize the rule of 10: simply
wet in solution (e.g. 5% vitamin C in 5% solvent).
Once homogenized, add the solution to the 100 g
Pharmax base and blend in with a hand blender or
ungulator if one is available. Blend until the cream
becomes homogenous. The product consistency
will result in a finished cream similar to that of
Pharmax™ Relief. Vitamins, minerals, melatonin,
gaba, amino acids, dextrose – virtually any watersoluble or fat soluble molecules with the exception
of large molecules like enzymes – can be blended.
INGREDIENTS
Sambucus Nigra Flower Extract, Sorbitan Olivate,
Dromecius Oil, Melaleuca Alternifolia (Tea Tree) Leaf Oil,
Rutin, Beeswax, Cetearyl Olivate, Benzoic Acid, Sodium
Hydroxide
n for healthcare professionals only
Warnings
For external use only.
Keep out of reach of children. If swallowed, get
medical help or contact a Poison Control Center right
away.
Pack Size
3.4 oz (100 g) Cream
17 oz (500 g) Cream
Product Code
TP08-100
TP08-500
Product Code
TP03-70
REFERENCES:
1. Boericke, W. Pocket Manual of Homeopathic Materia Medica and Repertory,
B. Jain Publishers Pvt. LTD, Delhi India. 1995: 167-168.
2. Boericke 76.
3. Kent, JT. Materia Medica of Homeopathic Remedies, Homeopathic Book
Service, London. 1989: 145.
4. Boericke 167-168.
5. Boericke 318.
6. Kent 564.
7. Wilkinson JA, Brown AM. Horse Chestnut - Aesculus Hippocastanum:
Potential Applications in Cosmetic Skin-care Products. Int J Cosmet Sci.
1999 Dec;21(6):437-47.
8. Boericke 156.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
7
Where Nutritional Science Comes to Life.
To order, call:
1-888-737-6925
[email protected]
For more information, visit:
www.seroyal.com/pharmax