2014 Class Book - Harvard Medical School

Transcription

Harvard Medical School M.D.-Ph.D. Class of 2014 Harvard Medical School M.D.-Ph.D. Class of 2014 Harvard Medical School M.D.-Ph.D. Class of 2014 Harvard Medical School M.D.-Ph.D. Class of 2014 Harvard
Medical School M.D.-Ph.D. Class of 2014 Harvard Medical School M.D.-Ph.D. Class of 2014 Harvard Medical School M.D.-Ph.D. Class of 2014 Harvard Medical School M.D.-Ph.D. Class of 2014 Harvard Medical
School M.D.-Ph.D. Class of 2014 Harvard Medical School M.D.-Ph.D. Class of 2014 Harvard Medical School
M.D.-Ph.D. Class of 2014 Harvard Medical School M.D.-Ph.D. Class of 2014 Harvard Medical School M.D.Ph.D. Class of 2014 Harvard Medical School M.D.-Ph.D. Class of 2014 Harvard Medical School M.D.-Ph.D.
Class of 2014 Harvard Medical School M.D.-Ph.D. Class of 2014 Harvard Medical School M.D.-Ph.D. Class
Dinner
of 2014 Harvard Medical School M.D.-Ph.D. Spring
Class of 2014
Harvard Medical School M.D.-Ph.D. Class of
2014 Harvard Medical School M.D.-Ph.D. Class
of 2014
Harvard Medical School M.D.-Ph.D. Class of 2014
May
27, 2014
Harvard Medical School M.D.-Ph.D. Class of 2014 Harvard Medical School M.D.-Ph.D. Class of 2014 Har-
HARVARD MEDICAL SCHOOL
MD-PhD
Class of 2014
Welcome
Welcome to the MD-PhD Program’s Annual Spring Dinner in honor of the MD-PhD Class of 2014 at
Harvard Medical School! We are especially delighted to welcome the family members and significant others
who are joining the graduates, faculty, students and staff to recognize our graduates tonight.
This year, twenty students will graduate from our program with both M.D. and Ph.D. degrees. This book
showcases the accomplishments of all the individuals among this select group. Together, these students
collectively completed 20 Ph.D. degrees and 20 M.D. degrees, spending roughly 160 years, or 7.95 years on
average per student, at graduate study since their matriculation into Harvard Medical School. This year’s
class of eight women and twelve men reflects the diversity of graduate training available to MD-PhD trainees
at Harvard Medical School. In all, they carried out their graduate studies in 11 different programs located
within Harvard University’s Graduate School of Arts & Sciences and the Massachusetts Institute of
Technology and 1 at the University of Oxford and another at the University of Cambridge in the United
Kingdom. Students pursued their dissertations in a wide range of fields from the basic sciences to
bioengineering to aeronautics/astronautics to health policy to medical anthropology.
Please spend a moment to read the individual biographies written by each of the students. Many spent their
early years in cities and towns across the United States (California, Colorado, Georgia, Maryland, Massachusetts, Missouri, New York, Ohio, Texas, Virginia, Washington and Wisconsin), as well as across the world
(Canada, China, France, India, Japan, Mexico, Puerto Rico, Switzerland, and Uruguay). They completed
their undergraduate degrees at 13 different colleges and universities including the California Technical
Institute, College of the Holy Cross, Georgia Institute of Technology, Harvard University, Johns Hopkins
University, Massachusetts Institute of Technology, Princeton University, Rice University, Stanford University,
University of California-Los Angeles, University of Pennsylvania, University of Washington, and Yale University. While at HMS, 14 enrolled in the London Health Sciences and Technology (HST) curriculum, while
6 joined the New Pathway, representing three of the four societies (1 Cannon, 3 Holmes, and 2 Peabody).
While these students are meeting the joint challenges of graduate and medical study, the MD-PhD Program
endeavors to provide a nurturing and cohesive environment for them. The program is fortunate to be able
to provide financial support for the majority of the graduates under the sponsorship of the NIH-Medical
Scientist Training Program (MSTP) Grant and other sources, and wishes it could provide full funding for
all. Program offerings, including special courses, advising sessions, retreats, dinners, symposia, lunches and
poster sessions, help us to bring diverse groups of training together in fulfilling our mission to “educate and
inspire the leading physician-scientists of the future.”
We congratulate the 2014 graduates on their numerous achievements and accomplishments towards the
completion of the M.D. and Ph.D. degrees and send our most heartfelt wishes for continued discovery,
success and happiness into the future.
Best wishes,
The Faculty and Staff of the MD-PhD Program
HARVARD MEDICAL SCHOOL
ANNUAL SPRING DINNER IN HONOR OF THE
MD-PhD
Class of 2014
May 27, 2014
The Joseph B. Martin Conference Center
6:00 PM
Cocktail Reception
Classic Jazz by Tal Shalom-Kobi Trio
7:00 PM
Seating for Dinner in the Rotunda
Welcome and Introduction of Graduates and Mentors
Dr. Loren Walensky
Director
Dean’s Champagne Toast to the Graduates
Dr. Jeffrey S. Flier
Dinner
After Dinner Special Remarks
Dr. Loren D. Walensky
Ms. Amy I. Cohen
Dr. Zirui Song
CONTENTS
Pages 2-3
Match Day Photo
Gallery
Pages 4-5
The Class of 2014
Pages 6-25
Graduates’ Biographies
Page 26
Mentors
Pages 27-33
Photo Galleries
Formal Group Photo of the Graduates
(in dining room at conclusion of remarks)
The MD-PhD Program welcomes the families and friends of the graduates.
1
1
GRADUATES CELEBRATE
MATCH DAY ON
MARCH 21, 2014:
1 (L-R) E. Rossin, Y. Hung, C. Lin, V. Auyeung,
V. Ganesh, I. Cajigas Gonzalez, A. Saltzman,
T. Sherry, Z. Song, E. Mayne, J. Canseco, A. Ravi,
S. Khormaee, Y. Rin, A. Xu, D. Buckland,
D. Mitra
2 P. Cunningham, Y. Ren
3a & b A. Xu
4 I. Cajigas Gonzalez, V. Ganesh, V. Auyeung,
Y. Ren, D. Mitra
5 A. Cohen, T. Sherry
6 A. Ravi, Y. Hung
7 E. Rossin, C. Lin
8 D. Mitra, T. Sherry, A. Saltzman
9 TMEC Atrium aerial view
10 L. Walensky, D. Buckland
11 E. Mayne, friend
2
2
3a
3b
4
6
5
7
8
5
10
11
9
3
Harvard Medical School
Class of 2014
Vincent C. Auyeung
B.S., California Institute of Technology (2005)
Ph.D., Massachusetts Institute of Technology in Biology (2012)
DISSERTATION: Sequence determinants of pri-miRNA recognition and
processing
M.D., Harvard Medical School (2014)
RESIDENCY: Internal Medicine at University of California,
San Francisco, CA
Page 6
Daniel A. Buckland
B.S., Georgia Technical Institute (2004)
Ph.D., Massachusetts Institute of Technology in Aeronautics and
Astronautics (2011)
DISSERTATION: Ultrasound imaging of cervical spine motion for
extreme acceleration environments
RESIDENCY: Emergency Medicine at George Washington University,
Washington, DC
Page 7
Iahn Cajigas González
Luis Nicolas Gonzalez Castro
B.S., Georgia Technical Institute (2004)
Ph.D., Harvard University in Engineering & Applied Sciences (2012)
DISSERTATION: Understanding generalization, credit assignment and
the regulation of learning rate in human motor learning
RESIDENCY: Preliminary Medicine at Massachusetts General
Hospital, Boston, MA
Neurology at Brigham & Women’s Hospital, Boston, MA
Page 11
Yin Pun (Rex) Hung
B.A., College of the Holy Cross (2004)
Ph.D., Harvard University in BBS (2012)
DISSERTATION: Single Cell Imaging of Metabolism with Fluorescent
Biosensors
RESIDENCY: Pathology at Brigham & Women’s Hospital, Boston, MA
Page 12
Sariah Khormaee
B.S., Massachusetts Institute of Technology (2002)
Ph.D., Massachusetts Institute of Technology in HST
MEMP/Electrical Engineering and Computer Science (2012)
DISSERTATION: Methods Toward Improved Lower Extremity
Rehabilitation
RESIDENCY: Neurological Surgery at Jackson Memorial Hospital,
Miami, FL
Page 8
B.S., B.S., University of Washington (2006)
Ph.D., NIH-GPP at University of Cambridge (UK) (2009)
DISSERTATION: Biological Properties of Poly(L-lysine isophthalamide)
RESIDENCY: Orthopaedic Surgery at Hospital for Special Surgery,
New York, NY
Page 13
José A. Canseco
ChieYu (Chewie) Lin
B.S., Rice University (2003)
Ph.D., Massachusetts Institute of Technology in HST MEMP (2013)
DISSERTATION: Tissue Engineering the Anterior Cruciate Ligament:
A Regenerative Medicine Approach in Orthopaedic Surgery
RESIDENCY: Orthopaedic Surgery at Hospital of the University of
Pennsylvania, Philadelphia, PA
Page 9
B.S., M.S., Yale University (2006)
DISSERTATION: Developmental Origins of Aggressive
Medulloblastoma
RESIDENCY: Pathology Clinical at Massachusetts General
Page 14
Vijay S. Ganesh
Elizabeth W. Mayne
A.B., Harvard University (2004)
Ph.D., Harvard University in Neuroscience (2012)
DISSERTATION: Identification and Characterization of Genes Essential for Human Brain Development
RESIDENCIES: Preliminary Medicine at Massachusetts General
Neurology at Brigham & Women’s Hospital, Boston, MA
Page 10
4
B.S., Stanford University (2005)
D.Phil., NIH-GPP at University of Oxford (UK) (2010)
DISSERTATION: G-Protein Coupled Receptor Mediated Modulation
of Network Activity in an in Vitro Model of Persistent Activity
RESIDENCY: Child Neurology at Stanford University Programs,
Stanford, CA
Page 15
MD-PhD Program
Devarati Mitra
DISSERTATION: The Role of Pigmentation and Oncogenic BRAF in
Melanoma
RESIDENCIES: Preliminary Medicine at Brigham & Women’s
Radiation Oncology at Brigham & Women’s Hospital, Boston, MA
Page 16
Amy Saltzman Porter
A.B., Princeton University (2005)
Ph.D., Harvard University in Anthropology (2013)
DISSERTATION: Mobile Patients, Static Response: (Mis)managing
well-being amidst South Africa’s dual epidemic
Page 17
Arvind Ravi
Ph.D., Massachusetts Institute of Technology in Biology (2011)
DISSERTATION: The Functional MicroRNA Landscape of Mammalian Development
RESIDENCY: Internal Medicine at Brigham & Women’s Hospital,
Boston, MA
Page 18
Yin Ren
B.S., Massachusetts Institute of Technology (2006)
Ph.D., Massachusetts Institute of Technology in HST/MEMP(2012)
DISSERTATION: Tumor-Penetrating Delivery of Small Interfering
RNA Therapeutics
RESIDENCY: Otolaryngology at HMS/Mass Eye & Ear Infirmary,
Boston, MA
Page 19
Elizabeth Rossin
B.S.E., University Pennsylvania (2005)
DISSERTATION: The proteomic landscape of human disease: construction and evaluation of networks associated to complex traits
RESIDENCIES: Preliminary Medicine at Massachusetts General
Ophthalmology at Mass Eye & Ear Infirmary, Boston, MA
Page 20
Key:
BBS: Biological and Biomedical Sciences
DGM: Division of General Internal Medicine
GPP: Graduate Partnership Program
Tisamarie B. Sherry
A.B., Princeton University (2005)
Ph.D., Harvard University in Health Policy (2012)
DISSERTATION: Maternal Health and Child Development Programs
in the United States and Rwanda: An Evaluation of Policies to Improve
Quality and Efficiency
RESIDENCY: Medicine-Primary/DGM
at Brigham & Women’s Hospital, Boston, MA
Page 21
Takahiro Soda
B.S., University of California, Los Angeles (2005)
Ph.D., Massachusetts Institute of Technology in Brain and Cognitive
Sciences (2012)
DISSERTATION: Converging biomedical pathways in psychiatric
disorders
RESIDENCY: Psychiatry at University of North Carolina,
Chapel Hill, NC
Page 22
Zirui Song
B.A., Johns Hopkins University (2006)
DISSERTATION: Financial Incentives in Health Care Reform:
Evaluating Payment Reform in Accountable Care Organizations and
Competitive Bidding in Medicare
RESIDENCY: Medicine-Primary at Massachusetts General Hospital,
Boston, MA
Page 23
Sae Takada
A.B., Harvard University (2003)
DISSERTATION: Quality of life, health-related stigma, and the social
context: longitudinal analyses of PLWHA in Uganda and a literature
review
RESIDENCY: Medicine-Primary at UCLA Medical Center,
Los Angeles, CA
Page 24
Amy J. Xu
A.B., M.A., Harvard University (2007)
Ph.D., Harvard University in Biophysics (2012)
DISSERTATION: Force Sensitivity of the von Willebrand Factor A2
Domain
RESIDENCIES: Preliminary Medicine at Brigham & Women’s
Radiation Oncology at Memorial Sloan-Kettering, New York, NY
Page 25
HST: Health Sciences and Technology
MEMP: Medical Engineering and Medical Physics
NIH: National Institutes of Health
5
Harvard MD-PhD Program Class of 2014
Vincent C. Auyeung
I grew up in Arcadia, California, the son of two highly supportive
(and endlessly patient) parents, Michael and Marianna. I spent much of my
childhood enamored of astronomy. However, in middle school I read several books about viral hemorrhagic fevers and had some fanciful ideas about
becoming a outbreak responder with the CDC, perhaps traveling to exotic
places to investigate arcane diseases.
My actual career has been considerably less dramatic, although my
interest in biology and medicine persisted. I went to Caltech to study biology.
There, I met Joanne Yim, who would become my wife (much later). I worked
in the lab of David Baltimore, working on gene therapy approaches to inhibit
HIV infection. I also joined a neurosurgery team for a month, which taught
me two valuable lessons: (1) that I wanted to serve patients clinically, and (2)
that I did not want to be a neurosurgical resident.
At Harvard, I met an amazing array of colleagues in the HST, the
MD-PhD, and the MIT Biology Programs. I worked in the lab of Dave Bartel,
and studied a family of regulatory RNAs called microRNAs. These tiny RNAs
start as much longer RNA precursors that are cut - twice - by cellular enzyme
complexes, and I discovered some of the mechanisms whereby these enzyme
complexes recognize the RNA precursors. After graduating, I will be starting
Internal Medicine residency at UC San Francisco.
6
Daniel A. Buckland
I consider the beginning of my MD-PhD to be my arrival in Boston in 2004 (Fig 1. Subject eating in airport headed to Boston) following a
summer of riding the rails of North America and graduation from Georgia
Tech in Atlanta, GA, where I grew up. With the goal of being an astronaut
I moved to Boston to begin a PhD in Aeronautics and Astronautics at MIT
and joined the HST MD program in 2006 when I realized that knowing
how to fix the humans in the rocket was as important as fixing the rocket
itself. After a few more years and a wedding to Dr. Sarah Miller, Ph.D. (Fig
2. Subject with wife) I completed my thesis under Brian D Snyder M.D.,
Ph.D. in the BIDMC Center for Advanced Orthopedic Studies and subsequently remained at BIDMC for my M3 year. Then, because I was in no
hurry to get a real job, Sarah and I did a year of post-doctoral research in
Basel, Switzerland. Next year I will be a resident in Emergency Medicine
based at the George Washington University Hospital in Washington, D.C.
I considered going into Neurosurgery, but felt that making an awesome
joke about being both a rocket scientist and a brain surgeon did not justify
spending 7 years in a residency I had no other interest in.
As I embark on my career as a Physician-Engineer I would like to
thank everyone in the MD-PhD Program for their support for my nontraditional decade-long pathway.
Fig. 1
Fig. 2
7
Iahn Cajigas González
I grew up in Aguadilla, Puerto Rico. While at the age of 7 months, I lost
my father in an airplane accident; I gained two additional parents in the form of
my grandparents. Together with my mother, they gave their all to raise my sister
and me. It was through their daily examples that I learned the value of hard work
and dedication.
I first came to Boston at the age of 18 to attend the Massachusetts Institute of Technology where I majored in Electrical Engineering and Computer
Science or “Course 6” (in MIT-speak). For my master’s thesis, I worked with
Steve Massaquoi - an electrical engineer and neurologist who used engineering
techniques to understand how the brain controls movement. With his encouragement and mentorship, I was fortunate even to be admitted to the HST and MDPhD Programs at HMS.
During my PhD, under the supervision of Emery N. Brown, I developed
statistical models of how neurons in the rat motor cortex fire during locomotion.
At the Spaulding Rehabilitation Hospital, under the supervision of Paolo Bonato,
I developed a technique to measure how short-term motor learning occurs
during gait – a technique that will hopefully allow us to track how individuals
re-learn to walk after injuries that affect their gait such as stroke or spinal cord
injury.
My training through the MD-PhD Program has uniquely prepared me
for neurosurgery residency at Jackson Memorial Hospital in Miami. My goal is
to someday help individuals to regain motor function using surgically implanted
devices that help correct or bypass the damage that disease has done.
Everything that I have been able to accomplish in life I owe to the incredible support of my family and friends. In particular, my grandparents, my mother,
sister, and my fiancé, Bibiana! I couldn’t have made it without you!
8
José A. Canseco
I was born in Mexico City, and grew up in Tapachula, Chiapas, the
southernmost state in Mexico. My family moved to Texas when I was a teenager, where I finished high school and attended Rice University. During my
undergraduate years, I learned about Tissue Engineering and Regenerative
Medicine, and started my quest to translate their therapeutic promise into
clinical realities. My journey continued as an MD-PhD student in HST, where
I quickly realized that I not only enjoyed the practice of Orthopaedic Surgery,
but that it was also one of the few fields where my research could have an immediate impact in patients’ lives. Thus, I joined Charles Vacanti’s lab to work
on ligament and cartilage regeneration, and on novel concepts in stem cell
biology applicable to regenerative medicine.
My path now continues in Philadelphia, where I will be an Orthopaedic Surgery resident at UPenn, and a researcher at the McKay labs - one of
the premier Tissue Engineering labs in Orthopaedics. Afterwards, I plan to
pursue a clinical fellowship in Sports Orthopaedics, and eventually become an
academic orthopaedic surgeon and a translational research scientist, trying to
bridge the gap between research innovations and patient care.
Somehow, halfway through my 11 years in HST (I know, it was
long…), I was lucky to have met the love of my life, Sarah, and been blessed
with two fantastic boys, Max and Sebastian. Without their unwavering support, that of my parents, siblings, mentors and everyone at HST and the MDPhD Program, I would not have been able to get to where I am today. Thank
you!
9
Vijay S. Ganesh
To distill a nearly decade-long experience into a few words is a difficult
exercise, not just because it induces countless hours of distracting nostalgia, but
because it ultimately requires falsely condensing one’s story into a convenient
linear narrative. For me, the reality of how motivation and inspiration in science
actually evolved was stochastic, and based way more on dumb luck than any active goal-setting or effort.
I grew up in a small town in Upstate New York, with two younger brothers, and my parents, who were engineers who immigrated from Bombay. I owe it
to them for setting the foundation, slogging through corporate jobs so we could
benefit from a comfortable middle class upbringing, where I was free to do anything, but not free to do nothing. My public schooling deserves some gratitude,
for affording me plenty of free time to develop an early interest in neuroscience
and evolution through reading and watching science fiction. Then I went to Harvard, stumbled into working with Christopher A. Walsh, and through him was
gifted an opportunity to experience the intoxicating fun of even small discoveries.
That enabled me to meet many other inspirational characters, in HST, in my MDPhD class, in the lab, and on the wards.
The aggregate effect of all that rich peer and mentor influence was to
reinforce the same interests I started with - neuroscience, genetics, and medicine
- only now with a slightly more tractable plan, and more people to help me along
the way.
10
Luis Nicolas Gonzalez Castro
I was born and raised in Montevideo, Uruguay. My wonderful parents Luis and Griselda, and my awesome brothers Martin and Ignacio, were
my main teachers during the first 18 years of my life. I then came to the U.S.
for college, first to Middle Georgia College – then the oldest junior college in
America – and 2 years later to the Georgia Institute of Technology, where I
studied aerospace engineering. After college I decided to continue at Georgia
Tech, as a graduate student in aerospace under Amy Pritchett and Eric Johnson – wonderful teachers and mentors – researching the design of control
interfaces for unmanned air vehicles. Witnessing through family experiences the limitations brought on by an ischemic stroke on the body’s ability
to move, I switched my research focus to studying how the brain controls
movement. I did my Ph.D. at Harvard under Maurice Smith, an incredibly
generous and supportive mentor. Through my research I was able to discover
several mechanisms by which we can accelerate the learning of a motor skill,
an important goal in rehabilitation. As a Ph.D. student in the Harvard-MIT
Division of Health Sciences and Technology (HST) I was heavily exposed to
medicine and after a 6-week clinical stint at Mount Auburn Hospital, I decided to apply to medical school. I was incredibly fortunate to be accepted to the
HST MD program at HMS and became affiliated with the MD-PhD Program
where I already had many friends. After graduation I will be a preliminary
medicine intern at the Massachusetts General Hospital (MGH), on my way
to the Harvard Neurology residency program at MGH and the Brigham and
Women’s Hospital (BWH). Before starting residency, I will be marrying my
lovely wife-to-be Silviya in Cambridge, MA.
11
Yin Pun (Rex) Hung
Born and raised in Hong Kong, Yin Pun (Rex) Hung came to the
United States at age sixteen. He attended the College of the Holy Cross in
Worcester, Massachusetts, where he majored in biology, minored in physics, and published his first research reports on crickets’ stridulation and
cold-atom quantum calculations. After one year of radiology research at
the Boston Children’s Hospital, he joined the Harvard Medical School New
Pathway MD program and the Biological and Biomedical Sciences (BBS)
PhD program. For his doctoral dissertation, he worked with Gary Yellen in
the Department of Neurobiology and developed novel protein-based optical
reporters for specific metabolites. By combining protein engineering with
live-cell microscopy, he investigated how metabolic dynamics and growth
factor signaling are integrated at the single cell level, as well as how this
metabolic-signaling network contributes to therapeutic resistance in tumor
cells. Upon returning to medical school, he became interested in surgical
pathology and onco-pathology. He aspires to integrate diagnostic work with
basic/translational oncology research. After graduation, he looks forward
to beginning residency in anatomic pathology at the Brigham and Women’s
Hospital. Besides his research and clinical training, he was at various times
a book collector, sushi connoisseur, violin/classical guitar player, and Red
Sox/Patriots fan. Rex thanks his advisor, Gary, for extraordinary mentorship, family, friends and mentors from Holy Cross and Harvard, Dr. Arky
and the staff at the Francis Weld Peabody Society, the BBS program, and the
MD-PhD Program.
12
Sariah Khormaee
After spending most of my life in the Pacific Northwest, it has been
an incredible gift to pursue my scientific and medical training on three different continents. My undergraduate mentor at the University of Washington, Tueng Shen, inspired me through her own example to combine science
and medicine. This led me to pursue a PhD in Chemical Engineering and
Biotechnology with two extraordinary supervisors, Nigel Slater at the University of Cambridge and John Park at the National Institutes of Health. The
subsequent HST MD developed my clinical skills, while providing a human
motivation for the science. It also exposed me to creative thinkers, like those
at Diagnostics for All. Working with them in Ho Chi Minh City encouraged
my optimism about global health and introduced me to my chosen field of
Orthopaedic Surgery. I am looking forward to my residency at the Hospital
for Special Surgery.
There are many who made this time invaluable. I am particularly
indebted to my PhD supervisors, John Park and Nigel Slater, and my MD thesis advisor, David Mooney. Special thanks to the Slater and Park Labs, who
showed me the pleasures of punting, pub lunches and Matuba Friday. I also
am grateful for my Orthopaedic Surgical mentors: Jeff Katz, Thomas Thornhill, George Dyer, Thomas Sculco, Young-Min Kwon, Harry Rubash, Benton
Heyworth and Arun Ramappa. Thank you to Yoshi who added appropriate
tasks to my “to do” lists. Finally, and most importantly, I am forever grateful
to my family for their love and support.
13
ChieYu (Chewie) Lin
I was born in Taiwan and grew up in Georgia in a loving home with
my spirited kid sister, Ming-Yee. Amidst annual trips to Disney World, my
parents taught us to not just work hard but never stop exploring, and most
importantly, to always have fun. And to eat. Everything.
After graduating high school, I worked in the lab of Sam Speck, which
first exposed me to bench research and molecular biology. My education continued at Yale as a Molecular Biophysics and Biochemistry student, where I
continued to learn about science in Susan Baserga’s group. During this time, I
decided to pursue a career that would combine my interest in and enthusiasm
for science and medicine, and was given the wonderful opportunity to move
up to Boston and join the HST program at Harvard Medical School.
My immersion in the HST and MD-PhD community at Harvard and
MIT have been invaluable in providing me with both like-minded colleagues
and inspiring mentors. For my PhD in the lab of Laurie Jackson-Grusby, I
studied brain tumor stem cells and affirmed my desire to better medicine
through the advancement of science. Most importantly, over the past 8 years, I
have both found love in an old friend Ann Ran and made many new life-long
friends in Boston. Surrounded by these people and supported by my family, I
am set to begin a new exciting chapter in pathology residency at MGH.
14
Elizabeth W. Mayne
I grew up in Colorado, where I worked at the Denver Museum of Nature and Science and competed in Freestyle Skiing and about six other sports
(with varying degrees of success). I’ve always been fascinated by trying to
figure out not just how something works, but why it works the way it does. So
I knew from a young age that I wanted to be a scientist. After trying out pretty
much every major at Stanford at least once and sometimes twice, I fell in love
with physiology, and headed off to Oxford, where I did my Ph.D. on GPCR
modulation of cortical UP and DOWN states in the mouse cortex with with
Dr. Ole Paulsen and collaborated with Chris McBain at the NIH.
After joining HST and the MD-PhD Program, I was fortunate to
work with Dr. Steven Stufflebeam, studying frequency-specific resting state
networks using MEG. Working with Dr. Stufflebeam sparked my interest in
epilepsy, which was reinforced in my rotations in neurology and child neurology. I am excited to return to Stanford for my child neurology residency.
I am grateful to my wonderful mentors, my labmates, and my friends
for all they have taught me along the way. First and foremost, I am profoundly
thankful for my family and their unstinting support at every step along the
way, from electric circuits and ill-fated baking soda volcanos to my adventures with mouse brains and MEG.
15
Devarati Mitra
I was born in Berkeley, CA to amazingly supportive parents who
worked in Biotech and fostered a love of science from early on. I finished
high school in Maryland where I was lucky enough to work with Ramanujan
Hegde at NIH. Manu’s excitement for discovery was contagious and inspired
me to think about a career bridging science and medicine. My experience in
college at Stanford further cemented this goal. Throughout it all, my brother’s
advice and support as an MD-PhD himself has been invaluable and ultimately helped lead me to the MD-PhD Program at HMS.
During my time in Boston, I’ve benefited from phenomenal mentorship, particularly from my thesis advisor, David Fisher. With his guidance
and the help of several hundred melanoma-prone red-headed mice, I discovered a passion for cancer biology. David also first introduced me to the field
of Radiation Oncology where I found my clinical niche and another wonderful mentor in Akila Viswanathan. During my graduate school years, I met Joe
Bailey, and after getting married earlier this week, I am excited to begin a new
chapter of our lives together.
I look forward to a Preliminary Internal Medicine year at Brigham &
Women’s Hospital followed by Residency at the Harvard Radiation Oncology Program. None of this would have been possible without the unwavering
support of my family, friends and mentors.
16
Amy Saltzman Porter
I grew up in Cleveland, Ohio, and spent kindergarten through twelfth grade at
Hathaway Brown School, where I first learned to ask tough questions and plan the research
to answer them. On the first day of freshman year at Princeton, I stumbled into a Medical
Anthropology class. There, I found my passion, met my lifetime mentor, João Biehl, and
little did I know, first crossed paths with my future husband, Steve Porter.
After graduating from Princeton, I moved to Cape Town, South Africa, to work for
a non-profit organization called mothers2mothers, which provides peer-based psychosocial support to pregnant women and new mothers recently diagnosed with HIV. Steve was
working for the organization at the time – and that’s where our journey together began.
We both started at HMS in 2006, Steve pursuing his MD/MBA. Somehow we managed to live the next eight years between Boston and South Africa. We are so grateful to
HMS, HBS, GSAS, the Department of Global Health and Social Medicine, and especially
the Social Sciences MD-PhD Program for making that dream possible. Our work in South
Africa has no doubt been the most fulfilling part of our interdisciplinary training to date.
Most recently, with Arthur Kleinman, Paul Farmer, and Jean Comaroff as my
guides, I returned to South Africa to conduct my ethnographic dissertation research for my
PhD in Anthropology, studying care-seeking and livelihood-seeking patterns among HIVand TB-infected labor migrants moving between Cape Town (where there is work) and
the Transkei, a region of the Eastern Cape province that was formerly a homeland under
apartheid (where many Xhosa-speaking South Africans call home). Doing this research and
writing my dissertation in South Africa allowed me to put my findings into action immediately, working in real time with organizations like the University of the Western Cape’s HIV
Research Centre and Medecins Sans Frontieres to think about how the health system can
better serve patients who are constantly on the move looking for both livelihood and care.
My time at Harvard has been made rich by my truly incredible mentors: Arthur
Kleinman, Paul Farmer, Jean Comaroff, Anne Becker, Allan Brandt, Pat O’Malley, Ed Lowenstein, David Urion, Mark Eisenberg, Norma Ware, and David Bangsberg. You have given
me innumerable gifts beyond description.
I am endlessly grateful to Steve and our daughter, Eloise, who arrived toward the
end of this long journey, as well as to our families – Mom, Dad, Andy, Grammy, Papa,
Melinda, Bob, Steve, Elena, Sam, Nike, Whitney, Paul, and Liv. Your love and support
throughout these last eight years has been essential and far beyond what I could have imagined.
Steve, Eloise, and I are very excited to be heading back to Cleveland this summer,
where Steve will start his OBGYN residency. I will apply to residency this coming year,
hoping to pursue a career in Pediatric Palliative Care that combines clinical medicine and
medical anthropology. We are so thankful for everything we have learned at Harvard and
cannot wait to get started with the next chapter.
17
Arvind Ravi
From an early age, Arvind was drawn to the sciences and their intersection with human health. First learning about research in his father’s ophthalmology laboratory as a high school student, he quickly gravitated to the
idea of applying math and science to better understand and treat disease.
Originally from St. Louis, MO, Arvind headed west to attend Stanford
University for college. A chemistry and mathematics major, he worked on an
honors thesis in the lab of Professor Chaitan Khosla examining novel therapies for multi-drug resistant tuberculosis.
Following college, Arvind joined HST as well as the MD-PhD Program. Working in the lab of Professor Phillip Sharp, Arvind explored the
mechanisms of cancer growth and division focusing on the new biological
elements known as microRNAs. In a thesis covering genetics, molecular biology, and evolution, his work has multiple applications in the areas of cancer
biology and early mammalian development.
Outside the hospital and lab, he is an avid distance athlete, having
completed a number of marathons and triathlons across the country. He looks
forward to continuing to explore the Northeast as an internal medicine resident at Brigham and Women’s Hospital.
18
Yin Ren
Yin Ren was born in Wuhan, China, a city mostly known for its summer heat and spicy food. At fifteen, his family moved to Windsor, Ontario
where he met Mr. Bruce White, a math teacher who inspired him to pursue
a career in math and science. Yin attended MIT where he studied electrical and biomedical engineering. In undergrad, Yin worked in the labs of Dr.
Jongyoon Han and Dr. George Chen in radiation oncology at MGH, and
developed his interest in problems at the interface of science, engineering, and
medicine.
In 2006, Yin joined the MD-PhD Program and was thrilled to work
in the laboratory of Dr. Sangeeta Bhatia. His PhD work focused on engineering nanoparticles that target cancer cells, penetrate tumor tissue, and deliver
small interfering RNA therapeutics in mice. In collaboration with Dr. William Hahn at the Broad Institute, this nanotechnology was applied to validate
new cancer targets found from genomic screens. Yin is grateful to Sangeeta
for teaching him how to identify problems, think critically and creatively, and
communicate effectively.
Yin is excited to begin his residency in Otolaryngology at the Masschusetts Eye and Ear Infirmary, where he hopes to study the genomics of
head and neck cancer and devise new therapies for diseases in the ear, nose,
and throat. In addition, he is grateful to the MD-PhD Program, his amazing
mentors and friends who have taught and inspired him. Lastly, he thanks his
parents, family, and fiancée, Julia, for all their support through the years.
19
Elizabeth Rossin
I am forever grateful for the support of my parents and the opportunities they gave me, without which I would not be where I am today. I was born
and raised in Newton, Massachusetts. I earned my undergraduate degree in
mechanical engineering at the University of Pennsylvania and joined HST
in 2007. During my PhD I studied medical and statistical genetics under the
guidance of Dr. Mark J. Daly, a leader and visionary in the field. I worked
on an algorithm to interpret genetic associations from large genotyping and
genome sequencing studies using a rigorous statistical framework to combine
large-scale proteomics data with human genetics. I had the opportunity to
work on a number of diseases, including Crohn’s disease, cardiac arrhythmia
and neuropsychiatric disease. I could not be more thankful to have had such
an inspiring, brilliant and kind mentor. After defending my dissertation and
returning to medical school, I unexpectedly found a great passion for ophthalmology and will be pursuing residency at MEEI after my preliminary year
at MGH. I hope to eventually study the genetics of complex and congenital
ophthalmic disease and to be involved in the emerging gene therapy trials
to restore vision in congenital blindness. The last seven years have been an
incredible journey, and I am extremely grateful to the MD-PhD Program for
having had this opportunity.
20
Tisamarie B. Sherry
After a somewhat nomadic upbringing between the US, India and
France, thanks to the MD-PhD Program I have spent 8 wonderful years in
Boston, my longest time in one place! I arrived here planning to stay for just
4 years for medical school, but soon realized that through the PhD Program
in Health Policy I could also explore my longstanding interests in economics and public policy, and better understand how these forces shape health
care. My PhD research evaluated approaches to improving the quality and
efficiency of maternal and child health services in the US and Rwanda, under
the wonderful guidance of my mentors Richard Frank, Thomas McGuire and
William Beardslee. Studying health policy in the midst of a national debate
about health care reform proved to be very timely: during graduate school I
had the privilege of joining my adviser, Richard Frank, and his team at the US
Department of Health and Human Services to study aspects of the Affordable
Care Act affecting health services for patients with severe psychiatric illness.
This experience reaffirmed my belief that research in medicine and health
policy can be translated into health system reforms with far-reaching impacts.
This summer I will begin my residency training in internal medicine
and primary care at Brigham and Women’s Hospital. I am so grateful to everyone who has inspired and supported me along this journey: my graduate and
medical school advisers, Anne Becker and the MD-PhD Program, and my
classmates and friends. And of course, I would be nowhere without my role
models: my family and my fiancé, Allen.
21
Takahiro Soda
I was born in Japan and ended up in California at the age of 6. What had been
an anticipated 3-4 year stay for my dad’s work turned into 10 years by the time he was
ready to leave. I am forever thankful to my parents for allowing me the opportunity to
stay in the US to continue my education. At at Mills High School I was lucky to have
encountered teachers such as Mr. Fortgang, Mr. Phillips, and Ms. Rustia whom inspired me to pursue a career in science.
My interest in the treatment of those with mental illness began as an undergraduate at UCLA, caring for the homeless on the streets of West Hollywood as part
of the UCLA Mobile Clinic Project, a student-run initiative that provides free medical services to the medically indigent populations of Greater West Los Angeles. There
I met inspiring clinicians such as Walt Coppenrath, and great advocates like Koy
Parada, that made me realize that my life should be dedicated to the care of mentally
ill patients. Through this experience, I also realized that in order to provide adequate
care, we needed a better understanding of the underlying biology of psychiatric disorders.
My first experience in research began during my freshman year in college, in
Dr. Gaylord Ellison’s lab. There, I studied the role of NMDA receptor antagonists as a
model for psychiatric illness and its role in the kindling of epileptiform activity with
guidance from Dr. Kevin Noguchi. Later on, I continued to conduct research under
Dr. Michael Levine, whose lab examined how genetic alterations found in Huntington’s disease led to electrophysiological changes in glutamatergic, GABAergic, and
dopaminergic responses of the medium-sized spiny neurons of the striatum. In Dr.
Levine’s lab I had great mentors such as Dr. Carlos Cepeda and Dr. Nanping Wu, as
well as the company of other driven students like Besim Uzgil and Max KleimanWeiner.
After completing my undergraduate degree in neuroscience at UCLA, I moved
to the east coast and joined the MD-PhD Program at Harvard Medical School, seeking to further my understanding of the biology and treatment of mental illness. Here,
I was given the opportunity to interact with the top physicians and some of the great
minds driving neuroscience research, including my mentor Dr. Li-Huei Tsai in the
Brain and Cognitive Sciences program at MIT. In her lab I learned the rigors and
rewards of academic research from her, as well as other lab members such as Drs. Yingwei Mao, Chris Frank, Karuna Singh, Dinos Meletis, and Zhigang Ghe. It was also
there that I initially met the love of my life and now wife.
I am thrilled to be continuing my training at UNC’s department of psychiatry,
where I hope to complete a fellowship in child and adolescent psychiatry and begin a
career that combines outreach, advocacy, clinical practice and translational research of
psychiatric manifestations of neurodevelopmental disorders.
22
Zirui Song
I was raised by two wonderful parents, my mom an English teacher
and my dad an oral surgeon. Growing up in Wisconsin, I became a fan of the
Green Bay Packers. My foam cheesehead traveled with me to upstate New
York, where I finished high school, then to Baltimore for college at Johns
Hopkins. Studying public health and economics there inspired me deeply,
leading me to become fascinated by the issues facing our health care system.
I was fortunate to pursue these interests as a medical student and
graduate student in the PhD Program in Health Policy at Harvard (Economics track). My dissertation focused on evaluating payment reform for physician organizations, Medicare fee changes, and the Medicare financing system.
I am incredibly grateful to my dissertation committee in the Department of
Health Care Policy for the opportunity to do this work. They are Michael
Chernew, PhD (chair), John Ayanian, MD, MPP, Thomas McGuire, PhD,
and Joseph Newhouse, PhD. I am also indebted to my classmates, who have
provided an amazing community of friends and colleagues.
Fond memories of the past eight years include working with the Massachusetts Medical Society, the Albert Schweitzer Fellowship in Boston, and
the students and fellow tutors of Cabot House at Harvard College. I have also
been blessed to share these years with my most supportive friend and partner
in life, Katie Koh, whose love and kindness have provided me an unwavering source of strength. Katie will be starting residency in the MGH-McLean
Psychiatry program, while I will be joining the MGH Internal Medicine program. We are grateful for the opportunity to train together and excited for the
journey ahead.
23
Sae Takada
I was born in Shimonoseki City in Western Japan, at the same clinic where
my mother was born. After relocating to the US at age 4, I spent most of my childhood in San Diego, immersed in math puzzles and piano. In college at Harvard, I
thought I was destined to go into mathematics until I took a job as a co-director
of a homeless shelter during my first summer. Since then, I was involved in public service and advocacy on campus, and was a Stride Rite Public Service Fellow.
Eager to learn how to address poverty at a global level, I went to the University of
Tokyo for a Master’s degree in Global Health Policy. While interviewing mothers and pediatricians in rural villages of Laos for fieldwork, I felt a strong desire
to provide something tangible to the community. This motivation to engage in
direct service while trying to address larger social forces was the foundation of
my MD-PhD training. Under the guidance of advisors Nicholas Christakis, David
Bangsberg, Arthur Kleinman, and Allan Brandt, I wrote my dissertation on social
support, social networks, quality of life and health-related stigma in rural Uganda.
The most important experience during graduate school was serving as a teaching
fellow for undergraduate courses in global health and medical sociology, where I
learned to engage others in thinking critically about how to build a better world.
After doing community health rotations as a fourth year medical student, I realized that I belonged in a community health center, and am thrilled to be taking
the next step as a Primary Care resident at UCLA.
I am extremely grateful for my PhD advisors, the administrative staff at
the MD-PhD Program, my society, and my doctoral department, and my classmates and family, for all the love and support along this long journey.
24
Amy J. Xu
My dream of becoming a physician scientist stems from my childhood.
Born to graduate students in Physiology and Physics, I was raised in a household filled with scientific curiosity. My father’s battle with a malignant thymoma exposed me to the power of compassionate physicians, yet, as I watched him
undergo multiple cycles of chemotherapy, open chest surgeries and radiation, I
was pained by the limitations of therapies that ultimately could not save his life.
As an MD-PhD student at Harvard Medical School, I learned the rigors
of basic science research while developing my passion for patient care. My
training with Timothy Springer taught me to probe structural mechanisms with
tenacious curiosity and I will forever strive to emulate his scientific brilliance. I
am eager for the opportunities that await in Radiation Oncology, and, after 11
years at Harvard, am thrilled to have matched at Memorial Sloan Kettering to
integrate my passion for physical science with clinical oncology.
I am indebted to my family for cultivating my love of learning and enriching my life with love and laughter. From my late father’s battle with cancer,
to my mother’s achievements as a tenured professor and single parent, to my
sister’s optimism in pursuing her own MD-PhD career, their resilience inspires my humanity and I cannot imagine more powerful relationships to draw
strength from. I am grateful for the opportunities I have been given at Harvard
and look forward to a career compelled by curiosity and compassion.
25
Class of 2014 Thesis Advisors
1
2
3a
3b
4
5
6
7
8a
8b8b
9
10a
10b
11
12
13
14
15
16a
16b
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18a
18b
26
1 Dr. David P. Bartel (Vincent Auyeung)
2 Dr. Brian D. Snyder (Daniel Buckland)
3a Dr. Emery N. Brown (Iahn Cajigas González)
3b Dr. Paolo Bonato (Iahn Cajigas González)
4 Dr. Charles A. Vacanti (Jose Canseco)
5 Dr. Chris A. Walsh (Vijay Ganesh)
6 Dr. Maurice A. Smith (Luis Nicolas Gonzalez Castro)
7 Dr. Gary I. Yellen (Yin Pun Hung)
8a Dr. John K. Park (Sariah Khormaee)
8b Dr. Nigel K. Slater (Sariah Khormaee)
9 Dr. Laurie L. Jackson-Grusby (ChieYu Lin)
10a Dr. Ole Paulsen (Elizabeth Mayne)
10b Dr. Chris J. McBain (Elizabeth Mayne)
19
20
11 Dr. David E. Fisher (Devarati Mitra)
12 Dr. Phillip A. Sharp (Arvind Ravi)
13 Dr. Sangeeta Bhatia (Yin Ren)
14 Dr. Mark J. Daly (Elizabeth Rossin)
15 Dr. Arthur M. Kleinman (Amy Saltzman Porter)
16a Dr. Richard G. Frank (Tisamarie Sherry)
16b Dr. Thomas G. McGuire (Tisamarie Sherry)
17 Dr. Li-Huei Tsai (Takahiro Soda)
18a Dr. Michael E. Chernew (Zirui Song)
18b Dr. Joseph P. Newhouse (Zirui Song)
19 Dr. Nicholas A. Christakis (Sae Takada)
20 Dr. Timothy A. Springer (Amy Xu)
1
2
1
4
3
5
6
5
27
7
8
1 G. Evrony, D. Shao, S. Blacklow, A. Subtelny, M. Feany, W. Ebina, Y. Zhang, A. Xu,
D. Konieczkowski, L. Custo Greig, M. Xiang, R. Koffie
2 V. Auyeung, friend, T. Soda, friends
3 L. Custo Greig, R. Koffie, A. Xu, Y. Zhang, D. Konieczkowski, K. Sue, M. Xiang,
D. Shao, G. Evrony, J. Bell, W. Ebina, A. Subtelny
4 friend, Y. Ren, friend, C. Lin, M. Lee
5 M. Lee, Y. Ren, K. Maciag, C. Sadegh, A. Halkovich, D. Mitra, E. Chen, Y. Yang, X.
Moisset, J. Abraham
6 S. Kimmel, A. Becker, K. Sue, A. Saltzman, Y. Chretien, T. Sherry, S. Takada
7 S. Kimmel, J. Heintz, A. Saltzman, P. Farmer, A. Kleinman, D. Djordjevic, K. Sue,
A. Becker
8 E. Williams, Y. Hung
9 HST end of year party, 2008
10 C. Lin, Y. Yang, Y. Ren
11 C. Lin, E. Rossin
12 S. Takada, A. Kleinman
13 Mark Brown – Leaders in Biomedicine Lecture, 2009
14 friends, C. Lin, E. Rossin, A. Xu
15 G. Evrony, A. Subtelny, Y. Zhang, D. Shao, L. Custo Greig, R. Koffie, A. Xu,
W. Ebina, J. Bell, D. Konieczkowski, M. Xiang
16 A. Xu, E. Rossin, friend
17 2014 graduates in picture: T. Soda, Y. Ren, A. Xu, N. Gonzalez, C. Lin
28
9
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13
3
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20
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31
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18 HST ICM course, 2008
19 J. Abraham, M. Lee, X. Moisset, C. Sadegh, Y. Yang, Y. Ren
20 C. Walsh, L. Burnley, S. Blacklow
21 J. Kreidberg, L. Burnley, J. Hirschhorn, C. Walsh, S. Blacklow,
X. Moisset, D. Mitra, J. Abraham, Y. Chen, Y. Ren, C. Sadegh,
S. Hill, Y. Yang , M. Andzelm, K. Maciag, A. Halkovich, M. Lee
22 Summer BBQ, 2005
23 J. Abraham, S. Hill, Y. Yang, M. Andzelm, K. Maciag, C. Sadegh,
Y. Chen, Y. Ren, M. Lee
24 Retreat, 2009
25 HST, Society Olympics, 2007
26 P. Farmer, J. Comaroff, A. Saltzman, A. Kleinman
27 Z. Song, T. McGuire
28 D. Buckland, Y. Yang, K. Maciag, M. Andzelm, Y. Chen, C. Lin,
C. Sadegh, friend, Y. Ren
29 J. Heintz, J. Lee, T. Sherry, D. Djordjevic, A. Schwartz, A. Hwong
30 M. Lee, J. Abraham, M. Andzelm, K. Maciag, E. Leitman, Y. Ren,
S. Blacklow, Y. Yang, Y. Chen, MD student, S. Hill, C. Sadegh
31 Y. Ren, J. Abraham, C. Sadegh
32 V. Aeyueng
32
33
Congratulations from all of us to the
MD-PhD Class of 2014!
www.hms.harvard.edu/md_phd

2014 Class Book - Harvard Medical School

Transcription

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