Volume 5, Issue 1 - May 2015

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Volume 5 Issue 1
May 2015
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STAR Max®
Diagnostica Stago is pleased to announce
the availability of the new STAR Max®.
INSIDE THIS ISSUE:
STAR Max®
Customer Corner
Paediatric and Microtainer racks
iHemOStasis and Haemoscore
2015 Stago Catalogue
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3
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5
6
STA ECA II
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STA Apixaban Cals and QC
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Stago Educational Websites
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Dates to remember
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This analyser is the most advanced fully
automated coagulation specific instrument
on the market today.
The STAR series instrument is the analyser
of choice in Public Hospitals throughout
Australia and New Zealand with approximately 90% of the largest labs utilising
Stago as the analyser of choice. The STAR
series analysers are equally suited to the
high throughput private labs and compatible with Total Lab Automation (TLA) solutions by all the major suppliers (over 150
STAR installations on TLAs world-wide).
The STAR Max® retains the best features
of the STAR series to ensure reliability of
the new platform. There are some unique
hardware innovations including a drop
down tray for easy front loading of the
cleaner solution as well as a space saving
slide-up side cover providing easy access
for cuvette loading.
The new software is brilliant incorporating
customisable Expert Rules. These Expert
Rules allow reflex testing to any test, reruns, the use of delta checks, autocomments, and auto-validation of results.
With accreditation in mind, the STAR
Max® features Method Validation software to assist in lot validation comparisons, repeatability studies, reproducibility
studies, carryover and Measurement of
Uncertainty calculations. Complete traceability for every patient result including
reagent lot number, QC, and consumables used in producing the result is available at anytime.
The STAR Max® software also features
easy to use workflow monitoring tools
including Turn Around Time for any test
customisable by date and time periods,
location etc assessed against your laboratory’s bench-mark.
You can even use the software to calculate your normal reference intervals including eg mean normal prothrombin
time.
This high throughput, flexible, feature
packed analyser is available now.
Please contact us to discuss the STAR
Max® and your laboratory needs:
[email protected]
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Stago Customers Corner
Stago Customers Corner is
available via the
www.stago.com.au website.
You simply log-in (clicking
the log-in button top right)
and you will get access to
all your data and available
services.
The information available
includes: your laboratory
data eg your analysers,
orders and ID-card;
Material Safety Data Sheets,
Package Inserts, Barcode
Sheets, Instrument
Documents, and Standard
Operating Procedures
If you would like access to
Customer Corner please
contact us for your log-in
and password - it’s free !
[email protected]
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STA Paediatric and Microtainer Racks
These Stago racks have been available
for a number of years enabling the easy
loading of paediatric and microcontainers onto the STAR series analysers. The
use of these racks speeds up the loading
of these samples.
samples without the operator needing to
specify this in the software.
“tells” the STAR that microvolume tubes
are in the rack.
From the Test panel screen, paediatric
samples loaded on these racks are displayed in green in the patient file list.
From the Test panel screen, microcontainers + adaptors loaded on these
racks are displayed in blue in the patient
file list.
The GREEN Stago Paediatric Rack is designed to accommodate the 1.8ml Becton Dickinson paediatric tubes presenting them at the perfect height for sampling. The rack features a barcode label
identifier which “tells” the STAR automatically that the rack contains paediatric
Dedicated BLUE racks for sample microvolumes (microcontainers/aliquots) are
used with the aluminum microtainer
adaptors. There is no need to manually
identify this sample type in the STAR
software as this rack is barcoded and
The catalogue numbers for these Stago
accessories are:
88349 Paediatric Rack
80203 Microtainer Rack
(2 racks per pack to suit all STAR series analysers.)
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iHemOStasis and Haemoscore Stago Apps for iPad and Android
Stago are pleased to announce the release
of our block buster applications iHemOStasis and Haemoscore. These applications
are available free of charge from the Apple
App Store and Google play worldwide.
The iHemOStasis tablet application serves
as a haemostasis primer for anyone looking
to increase knowledge in the area. The
uncomplicated user interface offers four
areas of interest:
Coagulation Cascade: Major coagulation
mechanisms are animated along with detailed explanations of each phase, including
intracellular and extracellular components.
Quick Guide: Detailed descriptions of the
most current assays used to examine hemostasis in a global fashion along with various therapies, disease state classifications
and decision trees.
Special Focus: Product literature supporting
Stago’s anticoagulant, thrombin generation
and flow cytometry products is housed,
along with reference ranges for hemostasis
tests in childhood and pregnancy.
Clinical Cases: Three case studies are presented, along with quizzes to test the viewer’s knowledge.
The Haemoscore app is available for tablet
and smartphone from the Apple Store and
Google play.
Clinical scores and algorithms play a central
role in modern patient care derived from
evidence-based medicine.
Evidence based medicine provides guidelines to physicians aimed at improving efficacy and safety of patient management.
An international expert panel has developed
this application that compiles, in a clear and
simples way, most recognised and useful
clinical scores and diagnosis algorithms in
the field of Thrombosis and Haemostasis.
Each algorithm includes the indication and a
brief interpretation emphasising the most
relevant aspects of each one followed by
some representative references.
We hope his application may guide the
clinician in the most appropriate diagnostic
strategy, answering some of the questions
that may arise when treating thrombotic
and bleeding problems.
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The Stago 2015 Haemostasis Catalogue is available in softcopy or hardcopy.
Please drop us a line if you would like one and specify the desired format: [email protected]
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STA® ECA II and Dabigatran Cal and QC
STA® - ECA II is intended for use with the
STA-R® analyzer for measuring the direct
anti-IIa activity of dabigatran in a competitive assay using a synthetic chromogenic
substrate. The kit allows the quantitative
determination of dabigatran in the plasma
of patients taking the drug. The measurement of dabigatran anti-IIa activity is converted into dabigatran plasma concentration. This concentration is helpful for clinicians to assess the extent of anticoagulation in situations requiring further characterisation of the clinical picture.
Dabigatran has been cleared without any
laboratory monitoring based on its safe
PK/PD profile and short half life. However,
in certain circumstances such as emergency surgery or severe bleeding, measuring
the plasma concentration of dabigatran
may be useful for helping physicians in
medical decisions.
The STA® - ECA II assay is based on the
cleavage of prothrombin by ecarin, a snake
venom metalloprotease from Echis carinatus. The generated activation products
(mainly meizothrombin) enzymatically
cleave a chromogenic substrate resulting in
paranitroaniline release. This cleavage is
inhibited in a concentration-dependent
manner by direct thrombin inhibitors (DTI),
when present in the plasma sample.
The quantity of paranitroaniline released
measured at 405 nm is inversely proportional to the amount of direct thrombin
inhibitors, such as dabigatran, present in
the plasma.
STA – ECA II contains 3 reagents
R1: Prothrombin – 3.5 mL
R2: Substrate – 2 mL
R3: Ecarin – 2 mL
The STA – ECA II reagents are stable on
board (Stago analyser) for 3 days but can
be stored in the refrigerator 2-8’C for 28
days.
The test turn around time is only 6
minutes.
The STA® ECA II working range is
15 to 460 ng/mL
The correlation of STA ECA II with HPLC/
MS measuring total dabigatran is excellent.
STA – Dabigatran Calibrator has 5 levels of
calibrators :
0 - 50 - 100 - 175 - 250 ng/mL
STA – Dabigatran Control
2 levels of control :
60 - 200 ng/mL
The kit is available now for use on STAR
and STAR Max. An adaption for the STA
Compact Max is expected later this year
(2015). This Ecarin-based chromogenic
assay is a specific method for DTI measurement providing accurate evaluation of
dabigatran levels in patients’ plasmas.
There is no interference from variations
of FII or fibrinogen levels, or from the
presence of heparin.
Look out for the poster at ISTH 2015,
Toronto by Dr Genevieve Freyburger.
00992 STA ECA II
00993 STA Dabigatran Calibrator
00994 STA Dabigatran Control
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STA® Apixaban Cals and Controls are now CE marked
The STA® - Apixaban Calibrator kit is a set
of calibrator plasmas intended for use with
STA-R® and STA Compact® for calibration
of the measurement of apixaban anti-Xa
activity using the STA® - Liquid Anti-Xa
(REF 00311) kit. (Standard Operating Procedures are also available for non Stago
instrumentation.)
STA - Apixaban Calibrator & Controls already available as RUO (Research Use Only) kits are now CE marked.
They retain the same catalogue numbers:
01075 STA - Apixaban Calibrator
01074 STA - Apixaban Control
STA - Apixaban Calibrator
excellent correlation to LCMS (the “gold”
standard).
•4 levels of calibrator : 0 - 100 - 250 - 500
ng/mL
Look out for the poster at ISTH 2015.
•Stability: 4 hours on board
STA - Apixaban Control
genic and specific anti-Xa method is not
affected by coagulation factors abnormalities, levels of plasma proteins, or other
drugs (except anti-Xa drugs).
Diagnostica Stago is the partner of choice
for the measurement of anticoagulants
with the complete range of Anti-Xa and
DTI test kits, calibrators and controls.
•2 levels of control : 80 - 300 ng/mL
[email protected]
•Stability: 8 hours on board and 7 days at
2/8°C
1800 4 STAGO (78246) AUS
Usually only one calibration is required per
lot number of STA Liquid Anti-Xa.
0508 4 STAGO (78246) NZ
The Working range is 23 to 500 ng/mL
Test Turn around time: 6 minutes
The STA Liquid Anti-Xa method with STA
Apixaban Cal & Ctrl provides accuracy,
precision, and allows the measurement of
apixaban (Eliquis®) in any clinical situation
eg prior to urgent surgery, in case of
bleeding, to assess compliance, and in
case of suspected overdose.
The STA Liquid Anti-Xa method using the
dedicated STA Apixaban Calibrators shows
The Stago 00311 STA Liquid Anti-Xa kit is
ideally suited to the urgent testing needs of
the busy laboratory. The liquid reagents
are barcoded and easy to use with long onboard and refrigerated stabilities.
STA Liquid Anti-Xa is truly a universal antiXa reagent with dedicated calibrators and
controls for heparin-like (UFH, LMWH and
Fondaparinux), Rivaroxaban, Apixaban and
Edoxaban (expected 2015). This chromo-
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Dates to Remember
Stago
Educational
Webinars
Website
Live webinars
24 hours per day
And available
7 days per week
on-demand
Stago-EdVantage.com
We are pleased to advertise the availability of educational resources at not
one but two Stago websites.
New science and the transfer of
knowledge leads to new standards of
care, better patient outcomes and
improved quality of life for the patients we serve.
On a regular basis, keynote speakers
present interesting and topical
presentations on a variety of topics.
The webinar is available to view live
at a scheduled time and is available
on the website to view on-demand a
short time later. The live event allows
interaction with the presenter in real
time.
To participate all you need to do is
register at the website to gain access
and reminders of upcoming events.
Diagnostica Stago, has long been
committed to providing educational
support to haemostasis testing laboratories. Our customers participate by
providing feedback and program
requests on specific topics that may
aid them in the use of our products
or provide knowledge to better serve
as their institution’s haemostasis resource.
Webinars on-demand currently available include: DDimers; HIT; NOACs;
LA; and the latest by Steve Kitchen
(UK) on QC in the Haemostasis Laboratory.
Australian and New Zealand participants can achieve APACE and CPD
continuing education credits and
certificates by registering and completing the activities on this site.
Please visit:
Please visit:
http://www.stagowebinars.com
http://www.stago-edvantage.com
Congratulations to
Kylie Twigg winner of the Stago
Prize awarded to the best
Bachelor of Biomedical Science
(Laboratory Medicine) student in
their final year of study in 2014
RMIT University
Diagnostica Stago Pty. Ltd.
651 Doncaster Road
Doncaster, VIC, 3108
Australia
Phone (AUS): 1800 4 STAGO
Phone (NZ): 0508 4 STAGO
AUSTRALIA - NEW ZEALAND
At the Heart of Haemostasis
Fax: +61 3 9855 8999
[email protected]
www.stago.com.au