Publikationliste Stefan Uhlig

Publikationliste Stefan Uhlig
Originalarbeiten
1. Uhlig, S., A. Wendel. 1990. Glutathione enhancement in various mouse organs and protection by
glutathione isopropyl ester against liver injury. Biochem. Pharmacol. 39: 1877-1881.
2. Görgen, I., T. Hartung, M. Leist, M. Niehörster, G.
Tiegs, S. Uhlig, F. Weitzel, A. Wendel. 1992. Granulocyte colony-stimulating factor treatment protects
rodents against lipopolysaccharide-induced toxicity
via suppression of systemic tumor necrosis factora. J. Immunol. 149: 918-924.
3. Uhlig, S., L. Wollin. 1994. An improved set-up for
the isolated perfused rat lung. J. Pharmacol. Tox.
Meth. 31: 85-94.
4. Uhlig, S., L. Wollin, A. Wendel. 1994. Contributions
of thromboxane and leukotrienes to platelet-activating factor-induced impairment of lung function
in the rat. J. Appl. Physiol. 77: 262-269.
5. Tiegs, G., J. Barsig, B. Matiba, S. Uhlig, A. Wendel.
1994. Potentiation by GM-CSF of LPS toxicity in
mice. J. Clin. Invest. 93: 2616-2622.
6. Uhlig, S., F. Brasch, L. Wollin, H. Fehrenbach, J. Richter, A. Wendel. 1995. Functional and fine structural
changes in isolated lungs challenged with endotoxin ex vivo and in vitro. Am. J. Pathol. 146: 1235-1247.
7. Uhlig, S., O. Heiny. 1995. Measuring the weight of
the isolated perfused rat lung during negative pressure ventilation. J. Pharmacol. Tox. Meth. 33: 147152.
8. Bundschuh, D., S. Uhlig, M. Leist, A. Sauer, A. Wendel. 1995. Isolation of rat primary lung cells. In vitro
Cell Dev. Biol. Anim. 31: 684-691.
9. Uhlig, S., A. v. Bethmann, R. Featherstone, A. Wendel.
1995. Pharmacological characterization of endothelinreceptorresponsesintheisolatedperfusedratlung.
Am. J. Respir. Crit. Care Med. 152: 1449-1460.
10. Uhlig, S., A. v. Bethmann. 1995. Endothelin-induced
bronchoconstriction in perfused rat lungs is partly
mediated by thromboxane. J. Cardiovasc. Pharmacol. 26: S111-S114.
11. Bohlinger, I., M. Leist, J. Barsig, S. Uhlig, G. Tiegs, A.
Wendel. 1995. Interleukin-1 and nitric oxide protect
against tumor necrosis factor α-induced liver injury
through distinct pathways. Hepatology 22: 18291837.
12. Gantner, F., S. Uhlig, A. Wendel. 1995. Quinine
potently inhibits release of tumor necrosis factor,
apoptosis, necrosis and mortality in a murine model
of septic liver failure. Eur. J. Pharmacol. 294: 353-355.
13. Uhlig, S., R. Nüsing, A. von Bethmann, R. L. Featherstone, T. Klein, F. Brasch, K.-M Müller, V. Ullrich,
A. Wendel. 1996. Cyclooxygenase-2 dependent
broncho­constriction in perfused rat lungs exposed
to endotoxin. Mol. Med. 2: 373-383.
14. Uhlig, S., R. Featherstone, O. Wilhelms, A. Wendel.
1996. Effects of urodilatin on platelet-activating
factor-induced bronchoconstriction, vasoconstriction and edema formation in perfused rat lung.
Naunyn Schmiedeberg’s Arch. Pharmacol. 354: 684688.
15. Martin, C., S. Uhlig, V. Ullrich. 1996. Videomicroscopy of methacholine-induced contraction of individual airways in precision-cut lung slices. Eur. Resp.
J. 9: 2479-2487.
16. von Bethmann, A. N., F. Brasch, K. Müller, A. Wendel, S. Uhlig. 1996. Prolonged hyperventilation is
required for release of tumor necrosis factor α but
not IL-6. Appl. Cardiopulm. Pathol. 6: 171-177.
17. Künstle, G., M. Leist, S. Uhlig, L. Revesz, R,
Feifel, A. MacKenzie, A. Wendel. 1997. ICEprotease inhibitors block murine liver injury
and apoptosis caused by CD95 or by TNF-a.
Immunol. Lett. 55: 5-10.
18. Held, H-D., A. Wendel, S. Uhlig. 1997. Phosphodiesterase inhibitors prevent endothelin-1-induced vasoconstriction, bronchoconstriction and thrombo­
xane release in perfused rat lung. Biochem. Biophys.
Res. Commun. 231: 22-25.
19. Held, H-D., M. Raschak, S. Uhlig. 1997. Rat big
endothelin-1-induced bronchoconstriction and
vasoconstriction in the isolated perfused rat lung:
role of endothelin converting enzyme and neutral
endopeptidase 24.11. Naunyn Schmiedeberg’s Arch.
Pharmacol. 355: 619-624.
20. Uhlig, S., A. v. Bethmann. 1997. Determination of
vascular compliance, interstitial compliance and
capillary filtration coefficient in rat isolated perfused lungs. J. Pharm. Tox. Meth. 37: 119-127.
21. Uhlig, S., R. Featherstone. 1997. Interaction of endothelin receptor responses in the isolated perfused
rat lung. Naunyn Schmiedeberg’s Arch. Pharmacol.
356: 392-397.
22. Uhlig, S., R. Featherstone, R. Nüsing, H. Held, C.
Schudt, A. Wendel. 1997. Attenuation by phosphodiesterase inhibitors of LPS-induced thromboxane
release and bronchoconstriction in rat lungs. J.
Pharmacol. Exp. Therap. 283: 1453-1459.
Uhlig Publikationen
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23. von Bethmann, A., F. Brasch, R. Nüsing, K.
Vogt, D. Volk, K-M. Müller, A. Wendel, S.
Uhlig. 1998. Hyperventilation induces release of cytokines from perfused mouse lung.
Am. J. Respir. Crit. Care Med. 157: 263-272.
24. Weisser, M., G. Tiegs, A. Wendel, S. Uhlig. 1998.
Quantification of apoptotic and lytic cell death by
video microscopy in combination with artificial
neural networks. Cytometry 31: 20-28.
25. Fehrenbach, H., F. Brasch, S. Uhlig, M. Weisser, C.
Stamme, A. Wendel, J. Richter. 1998. Early alterations in intracellular and alveolar surfactant of the
rat lung in response to endotoxin. Am. J. Respir. Crit.
Care Med. 157: 1630-1639
26. Held, H-D., C. Martin, S. Uhlig. 1999.
Characterization of airway and vascular responses
in murine lungs. Brit. J. Pharmacol. 126: 1191-1199.
27. Stamme, C., D. S. Bundschuh, T. Hartung, U. Gebert,
L. Wollin, R. Nüsing, A. Wendel, S. Uhlig. 1999. Temporal sequence of pulmonary and systemic inflammatory responses to graded polymicrobial peritonitis in mice. Infect. Immun. 67: 5642-5650.
28. Falk, S., R. Göggel, U. Heydasch, F. Brasch,
K. M. Müller, A. Wendel, S. Uhlig. 1999.
Quinolines attenuate PAF-induced pressor responses and edema formation. Am. J. Respir. Crit. Care
Med. 160: 1734-1742.
29. Verbrugge, S. J. C, S. Uhlig, S. J. C. M. M. Neggers, C.
Martin, H.-D. Held, J. J. Haitsma, B. Lachmann. 1999.
Different ventilation strategies affect lung function
but do not increase tumor necrosis factor-α and
prostacyclin production in lavaged rat lungs in vivo.
Anesthesiology 91: 1834-1843.
30. Held, H.-D., S. Uhlig. 2000. Comparison of basal lung
mechanics as well as airway and pulmonary vascular responsiveness among different inbred mouse
strains. J. Appl. Physiol. 88: 2192-2198.
31. C. Martin, V. Ullrich, S. Uhlig. 2000. Differential effects of thromboxane and endothelin on large and
small airways in precision-cut lung slices. Eur. Respir.
J. 16: 316-323.
32. Martin, C., H.-D. Held, S. Uhlig. 2000. Differential
effects of the mixed ETA/ETB-receptor antagonist
bosentan on endothelin-induced bronchoconstriction, vasoconstriction and prostacyclin release.
Naunyn Schmiedeberg’s Arch. Pharmacol. 362: 128136.
33. Wagner, F., S. Rottem, H.-D. Held, S. Uhlig, U.
Zähringer. 2000. Ether lipids in the cell membrane
of Mycoplasma fermentans. Eur. J. Biochem. 267:
6276-6286.
34. Held, H.-D., S. Uhlig. 2000. Mechanisms of endotoxin-induced airway and pulmonary vascular hyperreactivity in mice. Am. J. Respir. Crit. Care Med. 162:
1547-1552
35. Haitsma, J.J., S. Uhlig, R. Göggel, S. J. Verbrugge, U.
Lachmann, B.Lachmann. 2000. Ventilator-induced
lung injury leads to loss of alveolar and systemic
compartmentalization of TNF-α. Intens. Care Med.
26: 1515-1522
36. Uhlig, S., A. Wohlsen, F. Brasch. 2000. Can airways
close completely? J. Appl. Physiol. 89: 2521-2522 (Letter).
37. Martin, C, S. Uhlig, V. Ullrich. 2001. Cytokine-induced bronchoconstriction in precision-cut lung
slices is dependent upon cylooxygenase-2 and
thromboxane receptor activation. Am. J. Respir. Cell.
Mol. Biol. 24: 139-145.
38. Wollin, L., S. Uhlig, R. Nüsing, A.Wendel. 2001. GMCSF potentiates LPS-induced bronchoconstriction
by a neutrophil and COX-2 dependent mechanism.
Am. J. Respir. Crit. Care Med. 163: 443-450.
39. Held, H.-D., S. Boettcher, L. Hamann, S. Uhlig. 2001.
Ventilation-induced chemokine and cytokine release is associated with activation of NF-κB and is
blocked by steroids. Am. J. Respir. Crit. Care Med
162: 711-716.
40. Martin, C., A. Wohlsen, S. Uhlig. 2001.
Changes in airway resistance by simultaneous exposure to TNFα and IL-1β. Am. J. Physiol. Lung Cell.
Mol. Physiol. 280: L595-L601.
41. Wohlsen, A., S. Uhlig, C. Martin. 2001. The early allergic response in small airways. Am. J. Respir. Crit.
Care Med. 163: 1462-1469.
42. Ehlers, S., J. Benini, H.-D. Held, C. Röck, G. Alber, S.
Uhlig. 2001. αβTCR+ cells and IFNγ, but not iNOS,
are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology. J. Exp. Med. 194: 1847-1859.
43. Martin, C., R. Göggel, V. Dal Piaz, C. Vergelli, M. P.
Giovannoni, M. Ernst, S.Uhlig. 2002. Airway relaxant and anti-inflammatory properties of a PDE-IV
inhibitor with low affinity for the high-affinity rolipram binding site. Naunyn Schmiedeberg’s Arch.
Pharmacol. 365: 284-289.
44. Haitsma, J. J., S. Uhlig, U. Lachmann, S. J. Verbrugge,
D. L.H. Poelma, B. Lachmann. 2002. Exogenous surfactant reduces ventilator-induced decompartmentalization of tumor necrosis factor α in the absence
of positive end-expiratory pressure. Intens. Care
Med. 28: 1131-1137.
Uhlig Publikationen
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45. Göggel, R., S. Hoffmann, R. Nüsing, S. Narumiya, S.
Uhlig. 2002. PAF-induced pulmonary edema is mediated by PGE2 and subsequent activation of voltage-gated potassium channels. Am. J. Respir. Crit.
Care Med. 166: 657-662.
46. Uhlig, U., J. J. Haitsma, D. L. Poelma, B.Lachmann,
S.Uhlig. 2002. Ventilation-induced activation of the
MAP kinase pathway. Eur. Respir. J. 20: 946-956.
47. Stamme, C., F. Brasch, A. von Bethmann, S. Uhlig.
2002. Effect of surfactant on ventilation-induced
mediator release in isolated perfused mouse lungs.
Pulm. Pharmacol. Therap. 15: 455-461.
48. Wohlsen, A., C. Martin, E. Vollmer, D. Branscheid, H.
Magnussen, W. M. Becker, U. Lepp, S. Uhlig. 2003.
The early allergic response in small airways of human precision-cut lung slices. Eur. Respir. J. 21: 10241032.
49. Göggel, R., W. Pittermann, W. Aulmann, S. Uhlig.
2003. Assessment of the acute pulmonary toxicity
of lamp oil aspiration in the isolated perfused rat
lung. Food Chem. Toxicol. 41:1029-33.
50. Kübler, W. M., U. Uhlig, T. Goldmann, G. Schael,
A. Kerem, K. Exner, C. Martin, E. Vollmer, S. Uhlig.
2003. Stretch activates nitric oxide production in
pulmonary vascular endothelial cells in situ. Am. J.
Respir. Crit. Care Med. 168: 1391-98.
51. Lee, J.H., J. de Azavedo, A. A. Khine, J. Schwartz, S.
Uhlig, A. S. Slutsky, H. Zhang. 2003. Modulation of
bacterial growth by TNF in vitro and in vivo. Am. J.
Respir. Crit. Care Med. 168: 1462-70 .
52. Haitsma, J. J., S. Uhlig, S. J. Verbrugge, R. Göggel, D.
L. Poelma, B. Lachmann. 2003. Injurious ventilation
strategies cause systemic release of IL-6 and MIP-2 in
rats in vivo. Clin. Physiol. Funct. Imaging. 23: 349-53.
53. Uhlig, U., H. Fehrenbach, R. A. Lachmann, T. Goldmann, E. Vollmer, B. Lachmann, S. Uhlig. 2004. A
phosphoinositide 3-OH kinase inhibitor prevents
ventilation-induced, but not LPS-induced NF-κB
activation and cytokine release. Am. J. Respir. Crit.
Care Med. 169: 201-8.
54. Lee, J.H., L. Del Sorbo, S. Uhlig, G. A. Porro, T.
Whitehead, S. Voglis, M. Liu, A.S. Slutsky, H. Zhang.
2004. Intercellular adhesion molecule-1 mediates
cellular cross-talk between parenchymal and immune cells after lipopolysaccharide neutralization.
J. Immunol. 172: 608-16.
55. 55.Wrigge H., U. Uhlig, J. Zinserling, E. BehrendsCallsen, G. Ottersbach, M. Fischer, S. Uhlig, C.
Putensen. 2004. Effects of mechanical ventilation
strategy on pulmonary and systemic inflammatory
response to major surgery. Anesth. Analg. 98: 775781.
56. Göggel, R., S. Winoto-Morbach, G. Vielhaber,
K. Lindner, Y. Imai, L. Brade, A. S. Slutsky, H.
Brade, S. Schütze , E. Gulbins, S. Uhlig. 2004.
PAF-mediated pulmonary edema: a new role
for acid sphingomyelinase and ceramide.
Nat. Med. 10: 155-160.
57. Hasegawa J., K. F. Wagner, D. Karp, D. Li, J. Shibata,
M. Heringlake, L. Bahlmann, R. Depping, J. Fandrey,
P. Schmucker, S. Uhlig. 2004. Altered pulmonary
vascular reactivity in mice with excessive erythrocytosis. Am. J. Respir. Crit. Care Med. 169: 829-835.
58. Martin, C., R. Göggel, A. Ressmyer, S. Uhlig. Pressor
responses to platelet-activating factor and thromboxane are mediated by Rho-kinase. Am. J. Physiol.
Lung Cell. Mol. Physiol. 287: L250-L257.
59. Uhlig, U, S. Uhlig, D. Branscheid, P. Zabel, E. Vollmer,
T. Goldmann. 2004. HOPE-technique enables Western blot analysis from paraffin-embedded tissues.
Pathol. Res. Pract. 200: 469-472.
60. dos Santos, C. C., B. Han, C. F. Andrade, X. Bai, S.
Uhlig, R. Hubmayr, M. Tsang, M. Lodyga, S. Keshavjee, A. S. Slutsky, M. Liu. 2004. DNA Microarray
analysis of gene expression in alveolar epithelial cells
in response to TNFa, LPS and cyclic stretch. Physiol.
Genomics 19: 331-42.
61. Göggel, R., S. Uhlig. 2005. The IP3-pathway mediates platelet-activating factor-induced pulmonary
edema. Eur. Respir. J. 25: 849-857.
62. Lindner, K., U. Uhlig, S. Uhlig. 2005. Ceramide alters
endothelial cell permeability by a non-apoptotic
mechanism. Brit. J. Pharmacol. 145: 132-140.
63. Imai, Y., K. Kuba, S. Rao, Y. Huan, F. Guo, B. Guan, P.
Yang, R. Sarao, T. Wada, H. Leong-Poi, M.A. Crackower, A. Fukamizu, C.C. Hui, L. Hein, S. Uhlig, A.
Slutsky, C. Jiang, J. M. Penninger. 2005. Angiotensinconverting enzyme 2 protects from severe acute
lung failure. Nature 436: 112-116.
64. Yamane, M., M. Liu, H. Kaneda, S. Uhlig, T.K. Waddell, S. Keshavjee. 2005. Reperfusion-induced gene
expression profiles in rat lung transplantation. Am.
J. Tansplant. 5: 2160-2169.
65. Wrigge, H., U. Uhlig, G. Baumgarten, J. Menzenbach, J. Zinserling, M. Ernst, D. Drömann, A. Welz,
S. Uhlig, C. Putensen. 2005. Mechanical ventilation
strategies and inflammatory responses to cardiac
surgery: a prospective randomized clinical trial. Intens. Care Med. 31: 1379-8.
66. Karagiannidisa, C., G. Hense, C. Martin, M. Epstein,
B. Rückert, P.-Y. Mantel, G. Menz, S. Uhlig, K. Blaser,
C.B. Schmidt-Weber. 2006. Overlapping functions
but differential expression of activin A and TGF-a
in asthma. J. Allergy Clin. Immunol. 117: 111-8.
Uhlig Publikationen
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67. Jin, J., H. Zeng, K-W. Schmid, M. Toetsch, S. Uhlig, T.
Möröy. 2006. The zinc finger protein gfi1 acts upstream of TNF to attenuate endotoxin-mediated
inflammatory responses in the lung. Eur. J. Immunol.
36: 421-430.
68. Dolinay, T., N. Kaminski, M. Felgendreher,
H. P. Kim, P. Reynolds, S.C. Watkins, D. Karp,
S. Uhlig*, A.M.K. Choi*. 2006. Gene expression profiling of target genes in ventilator-induced lung injury. Physiol. Genomics 26: 68-75.
*, equal contribution from both laboratories.
69. Erpenbeck V.J., M. Ziegert, D. Cavalet-Blanco, C.
Martin, R. Baelder, T. Glaab, A. Braun, W. Steinhilber,
B. Luettig, S. Uhlig, H. G. Hoymann, N. Krug, J. M.
Hohlfeld. Surfactant protein D inhibits early airway
response in Aspergillus fumigatus-sensitized mice.
Clin. Exp. Allergy 36: 940-40.
70. Heinzelmann, F., V. Jendrossek, K. Lauber, R. Boras, T.
Eldh, K. Nowak, R. Handrick, M. Henkel, C. Martin,
S. Uhlig, D. Köhler, H. K. Eltzschig, W. Budach, C.
Belka. 2006. Irradiation-induced pneumonitis mediated by the CD95/CD95-ligand system. J. Natl. Canc.
Inst. 98: 1248-1251.
71. Ressmeyer, A.R., A.K., Larsson, S.E. Dahlèn, S. Uhlig,
C. Martin. 2006. Characterization of guinea pig precision-cut lung slices. Eur. Respir. J. 28: 603-611.
72. Uhlig, U., D. Drömann, T. Goldmann, H. Dombrowsky, E. Vollmer, P. Zabel, S. Uhlig. 2006. Pulmonary responses to overventilation in late multiple
organ failure. Anesthesiology 105: 1192-1200.
73. Sausbier, M., X-B. Zhou, C. Beier, U. Sausbier, D. Wolpers, S. Maget, C. Martin, A. Dietrich, A-R. Ressmeyer, H. Renz , J. Schlossmann, F. Hofmann, W. Neuhuber, T. Gudermann, S. Uhlig, M. Korth, P. Ruth. 2007.
Reduced rather than enhanced cholinergic airway
constriction in mice with ablation of the large conductance Ca2+-activated K+ channel. FASEB J, 21: 812822.
74. von Bismarck, P., C-F. G Wistädt, K. Klemm, S. Winoto-Morbach, U. Uhlig, S. Schütze, S. Uhlig, B. Lachmann, M. F. Krause. 2007. Surfactant “fortification”
by topical inhibition of nuclear factor-kB activity in
a newborn piglet lavage model. Crit. Care Med. 35:
2309-2318.
75. Dombrowsky, H., S. Uhlig. 2007. Effects of steroids
on ventilation-induced histone acetylation and
gene transcription. Eur. Respir. J. 30: 865-877.
76. Dembinski, R., S. Terbeck, N. Hochhausen, C. Dassow, S. Uhlig, M. Schneider, A. Schachtrupp. D. Henzler, R. Rossaint, R. Kuhlen. Pumpless extracorporeal
lung assist for protective mechanical ventilation in
experimental lung injury. Crit. Care Med. 35: 23092318.
77. Vaschetto, R., J. Kuiper, J. Chiang, J. Haitsma, J. Juco,
S. Uhlig, F. Plötz, F. Corte, H. Zhang, A. Slutsky.
2008. Inhibition of poly(adenosine diphosphateribose) polymerase attenuates ventilator-induced
lung injury. Anesthesiology 108: 261-8.
78. von Bismarck, P., C.-F. G. Wistädt, K. Klemm, S.
Winoto-Morbach, U. Uhlig, S. Schütze, D. Adam B.
Lachmann, S. Uhlig, M. F. Krause. 2008. Improved
pulmonary function by acid sphingomyelinase inhibition in a newborn piglet lavage model. Am. J.
Respir. J. Crit. Care Med. 177: 1233-1241.
79. Meier, T., A. Lange, H. Papenberg, M. Ziemann, C. Fentrop, U. Uhlig, P. Schmucker, S. Uhlig*, C. Stamme. Pulmonary cytokine responses during mechanical ventilation of non-injured lungs with and without endexpiratory pressure. Anesth. Analg. 107: 1265-1275.
*, corresponding author.
80. Henjakovic. M., K. Sewald, S. Switalla, D. Kaiser, M.
Müller, T. Z. Veres, C. Martin, S. Uhlig, N. Krug, A.
Braun. 2008. Ex vivo testing of immune responses in
precision cut lung slices. Toxicol. Appl. Pharmacol.
231: 68-76.
81. Henjakovic M., C. Martin, H. G. Hoymann, K.
Sewald, A. Ressmeyer, C. Dassow, G. Pohlmann, N.
Krug, S. Uhlig, A. Braun. 2008. Ex vivo lung function
measurements in precision cut lung slice (PCLS)
from chemical allergen sensitized mice represent
a suitable alternative to in vivo studies. Toxicol. Sci.
106: 444-453.
82. Spieth, P.M., A.R. Carvalho, P. Pelosi, C. Hoehn, C.
Meissner, M. Kasper, M. Hübler, M. von Neindorff,
C. Dassow, M. Barrenschee, S. Uhlig, T. Koch, M.
Gama de Abreu. 2009. Variable tidal volumes improve different lung protective ventilation strategies in experimental lung injury. Am J. Respir. Crit.
Care Med. 179: 684-693.
83. Roth, A.G., D. Drescher, Y. Yang, S. Redmer, S. Uhlig,
C. Arenz. 2009. Bisphosphonates are Potent and Selective Inhibitors of Acid Sphingomyelinase. Angew.
Chem. Int. Ed. Engl. 48: 7560-7563.
84. Dombrowsky, H., M. Barrenschee, M. Kunze, S.
Uhlig. 2009. Conserved responses to trichostatin
A in rodent lungs exposed to endotoxin or stretch.
Pulm. Pharmacol. 22: 593-602.
Uhlig Publikationen
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85. Pruessmeyer, J., C. Martin, F.M. Hess, N. Schwarz, S.
Schmidt, T. Kogel, N. Hoettecke, B. Schmidt, A. Sechi, S. Uhlig, A. Ludwig. 2010. ADAM17 mediates
constitutive and regulated shedding of syndecan-1
and -4 by epithelial cells. J. Biol. Chem. 285: 555-64.
86. Rüter,D., H.-P. Hauber, D. Drömann, P. Zabel, S.
Uhlig*. 2010. Low frequency ultrasound permeates
the human thorax: a novel way of non-invasive lung
testing. Ultraschall Med - Eur. J. Ultrasound. 31: 5362.
87. Yang, Y., J. Yin, W. Baumgartner, R. Samapati, E.A.
Solymosi, E. Reppien, W. Kübler, S. Uhlig. 2010.
Platelet-activating factor reduces endothelial NO
production - Role of acid sphingomyelinase. Eur.
Respir. J. 36: 417-427.
88. Lautenschläger, I., H. Dombrowsky, I. Frerichs, S-C.
Kuchenbecker, S. Bade, H. Schultz, P. Zabel, J. Scholz,
N. Weiler, S. Uhlig. 2010. A Model of the Isolated
Perfused Rat Small Intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 298: G304-G313
89. Dassow, C., L. Wiechert, C. Martin, S. Schumann, G.
Müller-Newen, O. Pack, J. Guttmann, W.A. Wall, S.
Uhlig. 2010. Biaxial distension of precision-cut lung
slices. J. Appl. Physiol. 108: 713-721.
90. Schwarz, N., J. Pruessmeyer, M.F. Hess, D. Dreymüller, E. Pantaler, R. Windoffer, M. Voss, A. Sarabi, C.
Weber, A. Sechi, S. Uhlig, A. Ludwig. 2010. Requirements for leukocyte transmigration via the transmembrane chemokine CX3CL1. Cell. Mol. Life Sci.
67: 4233-4248.
91. Barrenschee, M., D. Lex, S. Uhlig. 2010. Effects of
the TLR2 agonists MALP-2 and Pam3Cys in isolated
mouse lungs. PLoS ONE 5(11): e13889.
92. Spieth, P.M., A.R. Carvalho, A. Güldner, M. Kasper,
R. Schubert, N.C. Carvalho, A. Beda, C. Dassow, S.
Uhlig, T. Koch, P. Pelosi, de Abreu, M.G. 2011. Pressure support improves oxygenation and lung protection compared to pressure-controlled ventilation and is further improved by random variation
of pressure support. Crit Care Med. 39: 746-755.
93. Schlepütz, M., S. Uhlig, C. Martin. 2011. Electric
field stimulation of precision cut lung slices. J. Appl.
Physiol. 110: 545-554.
94. Rausch, S., C. Martin, S. Uhlig, W.A. Wall. 2011. Material model of lung parenchyma based on living
precision-cut lung slices. J. Mech. Behav. Biomed. 4:
583-592.
95. Spieth P.M., A. Güldner, A. R. Carvalho, M. Kasper,
P. Pelosi, S. Uhlig, T. Koch, M. Gama de Abreu. 2011.
Open lung approach vs acute respiratory distress
syndrome network ventilation in experimental
acute lung injury. Brit. J. Anaesth. 107: 388-97.
96. Dombrowsky, H., I. Lautenschläger, N. Zehethofer,
B. Lindner, H. Schultz, S. Uhlig, I. Frerichs, N. Weiler. Ingestion of n-3 fatty acids augments basal and
platelet activating factor-induced permeability to
dextran in the rat mesenteric vascular bed. J. Nutrition 141:1635-42.
97. Seehase S, M. Schlepütz, S. Switalla, K. Mätz-Rensing, F.J. Kaup, M. Zöller, C. Schlumbohm, E. Fuchs,
HD. Lauenstein, C. Winkler, AR. Kuehl, S. Uhlig, A.
Braun, K. Sewald, C. Martin. 2011. Bronchoconstriction in non-human primates: A species comparison.
J. Appl. Physiol. 111: 791-798.
98. Reiss, L.K., A. Kowallik, S. Uhlig. 2011. Recurrent
recruitment manoeuvres improve lung mechanics
and minimizes lung injury during mechanical ventilation of healthy mice. PLoS ONE 6(9):e24527.
99. Kunzmann, S., J.J. Collins, Y. Yang, S. Uhlig, S. Kallapur, C.P. Speer, A.H. Jobe, B.W. Kramer. 2011. Antenatal inflammation reduces Cav-1 expression and
influences multiple signaling pathways in preterm
fetal lungs. Am J Respir Cell Mol Biol. 45: 969-976.
100.Klug, K., S. Ehlers, S. Uhlig, N. Reiling. 2011. Mitogenactivated protein kinases p38 and ERK1/2 regulated
control of M. avium replication in primary murine
macrophages is independent of TNF and IL-10. Innate immunity 17: 470-485.
101. Inhalative IL-10 attenuates pulmonary inflammation following hemorrhagic shock without major
alterations of the systemic inflammatory response.
2012. Kobbe, P., P. Lichte, H. Schreiber, L. K. Reiss,
S. Uhlig, H.-C. Pape, R. Pfeifer. Med. Inflammation
2012: 512974.
102.Rieg, A.D., R. Rossaint, S. Uhlig, C. Martin. 2011. Differential effects of cardiovascular agents in the pulmonary artery and vein - implications for pharmacological therapy. PLoS One 6(12): e29698.
103.Samapati, R. Y. Yang, J. Yin, C. Stoerger, C. Arenz,
A. Dietrich, T. Gudermann, D. Adam, S. Wu, M.
Freichel, V. Flockerzi, S. Uhlig*, W. M. Kübler*. 2012.
Lung endothelial Ca2+ and permeability response
to PAF is mediated by acid sphingomyelinase and
TRPC6. Am. J. Respir. Crit. Care Med. 185: 160-170,
* shared last authorship. Selected for cover.
104.Morenz, K., H. Biller, F. Wolfram, S. Leonhardt, D. Rüter, T. Glaab, S. Uhlig*, J. Hohlfeld.
2012. Detection of air trapping in chronic obstructive pulmonary disease by low frequency ultrasound. BMC Pulm. Med. 16; 12(1);8
*, corresponding author
Uhlig Publikationen
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105.Dreymueller, D., C. Martin, T. Kogel, J. Pruessmeyer,
F.M. Hess, K. Horiuchi, S. Uhlig, A. Ludwig. 2012.
Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharide. EMBO
Mol. Med. 5: 412-423.
106.Cioffi, D.L., S. Wu, H. Chen, M. Alexeyev, C. M. St.
Croix, B. R. Pitt, S. Uhlig, T. Stevens. 2012. Orai1
determines calcium selectivity of an endogenous
TRPC heterotetramer channel. Circ. Res. 110: 14351444.
107. Siegl, S., S. Uhlig. 2012. Using the one-lung method
to link p38 to pro-inflammatory gene expression
during overventilation in C57BL/6 and BALB/c mice.
PLoS ONE 7(7): e41464.
108.Preuß, S., S. Stadelmann, F.D. Omam, J. Scheiermann,
S. Winoto-Morbach S, P. von Bismarck, F. KnerlichLukoschus, D. Lex, S. Adam-Klages, D. Wesch, J.
Held-Feindt, S. Uhlig, S. Schütze, M.F. Krause. 2012.
Inositol-trisphosphate reduces alveolar apoptosis
and pulmonary edema in neonatal lung injury. Am.
J. Respir. Cell. Mol. Biol. 47: 158-169 .
109.Schlepütz, M., A. Rieg, S. Seehase, J. Spillner, A.
Perez-Bouza, T. Braunschweig, T. Schroeder, M. Bernau, V. Lambermont, C. Schlumbohm, K. Sewald,
R. Autschbach, A. Braun, B.W. Kramer, S. Uhlig, C.
Martin. 2012. Mechanisms of neuronal airway control in human and other species. A comparative
study using precision-cut lung slices (PCLS). PLoS
One 7(10):e47344.
110.Preuß, S., F.D. Omam, J. Scheiermann, S. Stadelmann,
S. Winoto-Morbach, P. von Bismarck, S. Adam-Klages, F. Knerlich-Lukoschus, D. Lex, D. Wesch , J. HeldFeindt, S. Uhlig, S. Schütze, M.F. Krause. 2012. Topical application of phosphatidyl-inositol-3,5-bisphosphate for acute lung injury in neonatal swine. J. Cell.
Mol. Med. 16: 2813-26.
111. Ichikawa, A., M. Morita, K. Kuba, S. Chida, H. Tezuka, H. Hara, T. Sasaki, T. Ohteki, V.M. Ranieri, C.C.
dos Santos, Y. Kawaoka, S. Akira, A.D. Luster, B. Lu,
J.M. Penninger, S. Uhlig, A.S. Slutsky, Y. Imai. 2013.
CXCL10-CXCR3 enhances the development of
neutrophil-mediated fulminant lung injury of viral
and non-viral origin. Am. J. Respir. Crit. Care Med.
87: 65-77.
112. Engel, M., R.M. Nowacki, L.K. Reiss, S. Uhlig, C.H.
Willems, N. Kloosterboer, J.F. van Iwaarden, A.C.
Sewing, M. Seehase, V.A. Lambermont, J.J. Collins,
L.J. Zimmermann, G.D. Vos, B.W. Kramer. 2013.
Comparison of recruitment manoeuvres in ventilated sheep with Acute Respiratory Distress Syndrome. Lung 191: 77-86.
113. Larsson, A.K., S.-E Dahlén, A.-R. Kühl, D. Lex, S.
Uhlig, C. Martin. 2013. Modulation of antigen-induced responses by serotonin and prostaglandin E2
via EP1 and EP4 receptors in the peripheral rat lung.
Eur. J. Pharmacol. 699: 141-149.
114.Rieg AD, Rossaint R, Verjans E, Maihöfer NA, Uhlig
S, Martin C. 2013. Levosimendan relaxes pulmonary
arteries and veins in precision-cut lung slices - the
role of KATP-Channels, cAMP and cGMP. PLoS One
18;8(6):e66195.
115.Verjans, E., K. Ohl, Y.Yu, R. Lippe, A. Schippers, J.
Roth, N. Wagner, S. Uhlig, K. Tenbrock, C. Martin.
2013. Overexpression of CREMα in T cells aggravates LPS-induced acute lung injury. J. Immunol.
191:1316-23.
116.Bruells, C.S., A.J. Smuder, L. K. Reiss, M.B. Hudson,
W.B. Nelson, M.P. Wiggs, K.J. Sollanek, R. Rossaint,
S. Uhlig, S.K. Powers. 2013. Negative pressure ventilation and positive pressure ventilation promote
comparable levels of ventilator-induced diaphragmatic dysfunction in rats. Anesthesiology 119: 65262.
117. Preuß, S., J. Scheiermann, S. Stadelmann, F.D. Omam,
S. Winoto-Morbach, D. Lex, P. von Bismarck, S.
Adam-Klages, F. Knerlich-Lukoschus, D. Wesch, J.
Held-Feindt, S. Uhlig, S. Schütze, M.F. Krause. 2013.
18:1/18:1-Dioleoyl-phosphatidylglycerol prevents alveolar epithelial apoptosis and profibrotic stimulus
in a neonatal piglet model of acute respiratory distress syndrome. Pulm Pharmacol Ther. 2013 Oct 15.
pii: S1094-5539(13)00175-2.
118.Bel-Brunona, A., S. Kehla, C. Martin, S. Uhlig, W.
A. Wall. Numerical identification method for the
non-linear viscoelastic compressible behaviour of
soft tissue using uniaxial tensile tests and image
registration - Application to rat lung parenchyma. J.
Mechan. Behavior Biomed. Materials¸ in press.
Reviews & Editorials
119. Uhlig, S., und A. Wendel. 1992. The physiological
consequences of glutathione variations. Life Sci. 51:
1083-1094.
120.Uhlig, S., J. Barsig, G. Tiegs und A. Wendel. 1994. Die
modulierende Wirkung von Kolonie-stimulierenden Faktoren in experimentellen Sepsis-Modellen.
Sepsis - Klinik und Grundlagenforschung im Dialog.
Herausgeber: Verein zur Förderung der Klinischen
und Experimentellen Molekularen Medizin e. V., S.
91-93.
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121. Uhlig, S. 1995. Analysis of edema formation in isolated perfused rat lungs ventilated by negative pressure. In Ninth Freiburg Focus on Biomeasurement,
Pharmacological evaluation of cardioprotective
substances. Biomesstechnik Verlag GmbH, March,
p. 152-161.
122.Uhlig, S., A. Wendel. Lipid mediators in perfused rat
lung. 1995. In Interdisziplinäre Aspekte der Pneumologie. Herausgeber: von Wichert, P. und Siegenthaler, Georg Thieme Verlag, Stuttgart, p. 66-74.
123.Bohlinger, I., M. Leist, J. Barsig, S. Uhlig, G. Tiegs, A.
Wendel. 1996. Tolerance against tumor necrosis
factor α (TNF)-induced hepatotoxicity in mice: the
role of nitric oxide. Toxicol. Lett. 82/83: 127-131.
124. Bundschuh, D., S. Uhlig, A. Wendel. 1996. Isolation
of rat primary lung cells: characterization of an improved method. Exp. Toxicol. Pathol. 48: 512-514.
125.von Bethmann, A., S. Uhlig. 1997. Side effects of mechanical ventilation: molecular mechanisms. Proceedings of the 12th Postgraduate Course in Critical
Care Medicine, A.P.I.C.E. ‘97, Trieste, Italy. Gullo, A.
(ed.), Springer, Berlin Heidelberg New York. 147-154.
126.Uhlig, S. 1998. The isolated perfused rat lung. In
Methods in Pulmonary Research. Eds: S. Uhlig and
A. E. Taylor. Birkhäuser Verlag, Basel. 29-55
127. Uhlig, S., H. D. Held, R. Göggel. 2000. In Applications of isolated perfused lungs. Proceedings of a
Workshop on Isolated Perfused Organs. Eds: W. Pittermann, M. Kiezmann, C. Grosse-Siestrup. Laboratory Animals Ltd., London, UK, 41-54.
128.Martin C, S. Uhlig. 2000. Lung functions in precision-cut lung slices. In Applications of isolated perfused lungs. Proceedings of a Workshop on Isolated
Perfused Organs. Eds: W. Pittermann, M. Kiezmann,
C. Grosse-Siestrup. Laboratory Animals Ltd., London, UK, 55-67.
129.Uhlig, S. 2000. Beatmungs-induzierte Lungenschäden – Gibt es sie? J. Anästhesie Intensivbehandlung 1: 208-210.
130.Martin, C., A. Wohlsen, S. Uhlig. 2000.
Asthmaanfall
unter
dem
Mikroskop.
WGL Journal 1/2000: 5-7.
131. Seydel, U., A. J. Ulmer, S. Uhlig, E. T. Rietschel. 2000.
Lipopolysaccharide, a membrane-forming and inflammation-inducing bacterial macromolecule. In:
Zimmer G, editor. Membrane Structure in Disease
and Drug Therapy. New York: Marcel Dekker Inc.
New York, 217-252.
132.Uhlig, S., N. Kapp, M. Weisser, J. Hamacher,
A. Wendel. 2000. Mechanisms of giant lamellar body formation in endotoxin-treated lungs.
Appl. Cardiopulm. Pathophysiol. 9: 294-295.
133.Uhlig, S. 2001.Der Einfluß des PEEP auf die beatmungs-induzierte Freisetzung pro-inflammatorischer Mediatoren. J. Anästhesie Intensivbehandlung 8: 264-265.
134.Uhlig, S., U. Uhlig. 2001. Molecular mechanisms
of pro-inflammatory responses in overventilated
lungs. Recent Res. Devel. Resp. Critical Care Med. 1:
49-58.
135.Uhlig, S, D. Burdon. 2002. Pro-and anti-inflammatory Cytokines and apoptosis in acute lung injury. In
Sepsis and Organ dysfunction: from chaos to rationale. Eds. A. E. Baue, G. Berlot, A. Gullo, J.-L. Vincent.
Milano: Springer Verlag, 77-93.
136.Uhlig, S. 2002. Ventilation-induced lung injury
and mechanotransduction: Stretching it too far?
Am. J. Physiol. Lung Cell. Mol. Physiol. 282: L892-L896.
137. Uhlig, S., K. Lindner. 2002. Novel mechanisms of
endothelial cell permeability in the lung. Lessons
from studies with intact lungs and animals. In The
microcirculation and vascular biology. Eds. J. Tooke,
A. Shore, J. Whatmore. Bologna: Monduzzi Editore,
221-234.
138.Uhlig, S. 2003. Taking a peep at the upper airways.
Am. J. Respir. Crit. Care Med. 168: 1026-7.
139.Uhlig, S., M. Ranieri, A. S. Slutsky. 2004. Biotrauma
Hypothesis of Ventilator-induced Lung Injury. Am J
Respir Crit Care Med. 169: 314-6 (Correspondence).
140.Uhlig, S., U. Uhlig. 2004. Pharmacological interventions in ventilator-induced lung injury. Trends in
Pharmacol. Sci. 25: 592-600.
141. Uhlig, S. Who tidies up the lung? Ask Cox-2 and
Nrf2. 2005. Am. J. Respir. Crit. Care Med., 171-11981999.
142.Hamacher, J., S. Heyder, R. Lucas, R. Schramm, G. W.
Sybrecht, S. Uhlig. 2005. Bronchoalveoläre Lavage
beim Nager. Pneumologie 59: 486-90.
143.Uhlig, S., R. Göggel, S. Engel. 2005. Mechanisms of
PAF-mediated responses in the lung. Pharmacol. Reports 57, suppl., 206-221.
144.Uhlig, S., Reppien. 2006. Die Bedeutung von Sphingolipiden für die Pathophysiologie der Lunge. Intensivmed. Notfallmed. 43: 247-251.
145.Winning, J, S. Uhlig, H. Huwer, R. Lucas, J. Hamacher.
2007. Die „weisse“ Lunge: Störungen der Flüssigkeitsbilanz. In Intensivbuch Lunge. Eds. T. Bein, M.
Pfeifer. Berlin: Med. Wissenschaftl. Verlagsgesellschaft, 143-189.
146.Uhlig, S., H. Held. 2007. Isolated perfused lung. In
Lung metastases and isolated lung perfusion. Eds. P.
van Schil. Nova Science Publishers, Inc., New York,
127-139.
Uhlig Publikationen
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147. Uhlig, S. 2007. Vom Barotrauma zum Biotrauma –
neue Ansätze zur protektiven Beatmung? ArzneimForsch/DrugRes 57: G752-G754.
148.Uhlig, S., I. Frerichs. 2008. Lungenprotektive Beatmung - Pathophysiologie und Diagnostik. AINS 43:
438-445.
149. Roggen, E., M. Aufderheide, Y. Cetin, R. J. Dearman,
S. Gibbs, I. Hermanns, I. Kimber, J. F. Regal, C. Rovida,
D. B. Warheit, S. Uhlig, S. Casati. 2008. Progress in
the development of novel approaches to the identification of chemical and protein respiratory allergens. ATLA 36: 591-598.
150.Uhlig, S., E. Gulbins. Sphingolipids in the lungs.
2008. Am. J. Respir. J. Crit. Care Med. 178: 1100-1114.
151. Uhlig, S., C. Martin. 2008. Bronchial Asthma. In
Encyclopedia of Molecular Pharmacology. 2nd Edition. Eds. Offermanns, S, Rosenthal, W. SpringerVerlag Berlin-Heidelberg-New York, p. 284-289.
152.Uhlig, S., C. Martin. 2008. Chronic obstructive pulmonary disease. In Encyclopedia of Molecular Pharmacology. 2nd Edition. Eds. Offermanns, S, Rosenthal, W. Springer-Verlag Berlin-Heidelberg-New
York, p. 362-366.
153.Floege, J, S. Uhlig. 2010. Kidney calling lung and callback: How organs talk to each other. Nephrol. Dial.
Transplant. 25: 32-24.
154.Kuebler, W.M., Y. Yang, R. Samapati, S. Uhlig. 2010.
Vascular barrier regulation by PAF, sphingomyelinase, caveolae, and NO – an intricate signaling network with discrepant effects in the pulmonary and
systemic vaculature. Cell. Physiol. Biochem. 26: 2940.
155.Uhlig, U., S. Uhlig. 2011. Ventilation-induced lung in
jury. Comprehensive Physiol. 1: 635-661.
156.Matute-Bello, G, G- Downey, B.B. Moore, S.D. Groshong, M.A. Matthay, A.S. Slutsky, W.M. Kuebler; on
behalf of the Acute Lung Injury in Animals Study
Group. 2011. An Official American Thoracic Society
Workshop Report: Features and Measurements of
Experimental Acute Lung Injury in Animals. Am. J.
Respir. Cell Mol. Biol. 44: 725-738.
157. Ludwig, A., A. Sommer, S. Uhlig. 2011. Assessment
of endothelial permeability and leukocyte transmigration in human endothelial cell monolayers.
Methods Mol. Biol. 763: 319-32.
158.Yang, Y., S. Uhlig. 2011. The role of sphingolipids in
respiratory disease. Ther. Adv. Respir. Dis. 5: 325-44.
159. Reiss, K., U. Uhlig, S. Uhlig. 2012. Models and mechanisms of acute lung injury caused by direct insults.
Eur. J. Cell Biol. 91: 590-601.
160.Uhlig, S., Y. Yang. 2013. Sphingolipids in Acute Lung
Injury. In: Sphingolipids in Disease. Eds. E. Gulbins, I.
Petrache. Handbook of Experimental Pharmacology
216, Springer-Verlag Wien, p. 227-246.
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