blood12422toc 7..9

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2014 124: 3177-3335
124 (22)
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20 NOVEMBER 2014 x VOLUME 124, NUMBER 22
CONTENTS
COVER FIGURE
Image of red fluorescent protein–expressing human umbilical vein endothelial cells
(RFP1 HUVECs) (red) in coculture with green fluorescent protein–expressing
(GFP1) MM1S myeloma cells (green) at day 9 of culture in endothelial growth
medium on 3-dimensional porous silk scaffolds (purple). GFP1 MM1S cell adherence
to RFP1 HUVECs and incorporation into the capillarylike endothelial cell structures
can be observed and may model the early stages of angiogenesis. GFP1 MM1S cells
are seen clustered and colocalized at endothelial protrusions. The image is the
maximum projection of z-stacked confocal images at 320 magnification on a Leica
SP5X laser scanning confocal microscope. See the article by Reagan et al on page 3250.
INSIDE BLOOD COMMENTARIES
3177
Polyphosphate: a target for thrombosis attenuation
Roberto Docampo
Comment on Travers et al, page 3183
3178
The end of knight-errantry in GVHD studies
Marcos de Lima
Comment on Bolaños-Meade et al, page 3221
3179
Not merely quiescent: telomeres in quiescent HSCs
Ayako Nakamura-Ishizu and Toshio Suda
Comment on Wang et al, page 3237
3180
Fc-optimized antibodies quickly pull the trigger
Christian Kellner and Matthias Peipp
Comment on Romain et al, page 3241
PLENARY PAPER
3183
Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis
Richard J. Travers, Rajesh A. Shenoi, Manu Thomas Kalathottukaren,
Jayachandran N. Kizhakkedathu, and James H. Morrissey
PERSPECTIVES
3191
Biosimilars: the science of extrapolation
Martina Weise, Pekka Kurki, Elena Wolff-Holz, Marie-Christine Bielsky,
and Christian K. Schneider
BLOOD SPOTLIGHT
3197
Brentuximab vedotin
Stephen M. Ansell
REVIEW ARTICLE
3201
The role of the thymus in T-cell immune reconstitution after umbilical cord blood
transplantation
Ioannis Politikos and Vassiliki A. Boussiotis
HOW I TREAT
3212
How I treat polycythemia vera
Alessandro M. Vannucchi
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BLOOD, 20 NOVEMBER 2014 x VOLUME 124, NUMBER 22
CONTINUED ON viii
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CLINICAL TRIALS AND
OBSERVATIONS
3221
CME Article
Phase 3 clinical trial of steroids/mycophenolate mofetil vs steroids/placebo as therapy
for acute GVHD: BMT CTN 0802
Javier Bolaños-Meade, Brent R. Logan, Amin M. Alousi, Joseph H. Antin, Kate Barowski,
Shelly L. Carter, Steven C. Goldstein, Elizabeth O. Hexner, Mary M. Horowitz, Stephanie J. Lee,
John E. Levine, Margaret L. MacMillan, Paul J. Martin, Adam M. Mendizabal,
Ryotaro Nakamura, Marcelo C. Pasquini, Daniel J. Weisdorf, Peter Westervelt, and Vincent T. Ho
3228
Safety and efficacy of rituximab in adult immune thrombocytopenia: results from
a prospective registry including 248 patients
Mehdi Khellaf, Ana¨ıs Charles-Nelson, Olivier Fain, Louis Terriou, Jean-François Viallard,
St´ephane Cheze, Julie Graveleau, Borhane Slama, Sylvain Audia, Mikael Ebbo,
Guillaume Le Guenno, Manuel Cliquennois, Gilles Salles, Caroline Bonmati, France Teillet,
Lionel Galicier, Arnaud Hot, Olivier Lambotte, François Lefr`ere, Salimatou Sacko,
Dieudonn´e Kilendo Kengue, Philippe Bierling, Françoise Roudot-Thoraval, Marc Michel,
and Bertrand Godeau
HEMATOPOIESIS AND
STEM CELLS
3237
Brief Report
Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic
stem cells with short telomeres
Jianwei Wang, Xin Lu, Vadim Sakk, Christoph A. Klein, and Karl Lenhard Rudolph
IMMUNOBIOLOGY
3241
Antibody Fc engineering improves frequency and promotes kinetic boosting of serial
killing mediated by NK cells
Gabrielle Romain, Vladimir Senyukov, Nicolas Rey-Villamizar, Amine Merouane,
William Kelton, Ivan Liadi, Ankit Mahendra, Wissam Charab, George Georgiou,
Badrinath Roysam, Dean A. Lee, and Navin Varadarajan
LYMPHOID NEOPLASIA
3250
Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone
marrow niche model
Michaela R. Reagan, Yuji Mishima, Siobhan V. Glavey, Yong Zhang, Salomon Manier,
Zhi Ning Lu, Masoumeh Memarzadeh, Yu Zhang, Antonio Sacco, Yosra Aljawai, Jiantao Shi,
Yu-Tzu Tai, John E. Ready, David L. Kaplan, Aldo M. Roccaro, and Irene M. Ghobrial
MYELOID NEOPLASIA
3260
BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein
Anupriya Agarwal, Ryan J. Mackenzie, Arnaud Besson, Sophia Jeng, Alyssa Carey,
Dorian H. LaTocha, Angela G. Fleischman, Nicolas Duquesnes, Christopher A. Eide,
Kavin B. Vasudevan, Marc M. Loriaux, Eduardo Firpo, Jorge E. Cortes, Shannon McWeeney,
Thomas O’Hare, James M. Roberts, Brian J. Druker, and Michael W. Deininger
3274
NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous
leukemia
Zohar Sachs, Rebecca S. LaRue, Hanh T. Nguyen, Karen Sachs, Klara E. Noble,
Nurul Azyan Mohd Hassan, Ernesto Diaz-Flores, Susan K. Rathe, Aaron L. Sarver,
Sean C. Bendall, Ngoc A. Ha, Miechaleen D. Diers, Garry P. Nolan, Kevin M. Shannon,
and David A. Largaespada
3284
GPR84 sustains aberrant b-catenin signaling in leukemic stem cells for maintenance
of MLL leukemogenesis
Philipp A. Dietrich, Chen Yang, Halina H. L. Leung, Jennifer R. Lynch, Estrella Gonzales,
Bing Liu, Michelle Haber, Murray D. Norris, Jianlong Wang, and Jenny Yingzi Wang
PLATELETS AND
THROMBOPOIESIS
3295
Clinical and laboratory predictors of chronic immune thrombocytopenia in children:
a systematic review and meta-analysis
Katja M. J. Heitink-Poll´e, Joyce Nijsten, Chantal W. B. Boonacker, Masja de Haas,
and Marrie C. A. Bruin
viii
BLOOD, 20 NOVEMBER 2014 x VOLUME 124, NUMBER 22
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3308
Epidemiology of incident immune thrombocytopenia: a nationwide population-based
study in France
Guillaume Moulis, Aurore Palmaro, Jean-Louis Montastruc, Bertrand Godeau,
Maryse Lapeyre-Mestre, and Laurent Sailler
THROMBOSIS AND
HEMOSTASIS
3316
Brief Report
Interleukin 27 inhibits cytotoxic T-lymphocyte-mediated platelet destruction in
primary immune thrombocytopenia
Hai Zhou, Ji-hua Qiu, Tong Wang, Ying-yi Yu, Xue-na Liu, Xin Li, Ya-wen Wang, Yu Hou,
Li-zhen Li, Xin-guang Liu, Ming Hou, and Jun Peng
TRANSPLANTATION
3320
CD41 invariant natural killer T cells protect from murine GVHD lethality through
expansion of donor CD41CD251FoxP31 regulatory T cells
Dominik Schneidawind, Antonio Pierini, Maite Alvarez, Yuqiong Pan, Jeanette Baker,
Corina Buechele, Richard H. Luong, Everett H. Meyer, and Robert S. Negrin
BLOOD WORK
3329
EBV-positive peripheral T-cell lymphoma with extensive hemophagocytosis
Mithun Vinod Shah and Ronald S. Go
CORRESPONDENCE
3330
KIR3DL2 is a coinhibitory receptor on S´ezary syndrome malignant T cells that
promotes resistance to activation-induced cell death
Nicolas Thonnart, Anne Caudron, Isabel Legaz, Martine Bagot, Armand Bensussan,
and Anne Marie-Cardine
3332
Nongenetic stochastic expansion of JAK2V617F-homozygous subclones in
polycythemia vera?
Anna L. Godfrey, Jyoti Nangalia, E. Joanna Baxter, Charles E. Massie, David G. Kent,
Elli Papaemmanuil, Peter J. Campbell, and Anthony R. Green
CONTINUING MEDICAL EDUCATION (CME) QUESTIONS
3335
Phase 3 study of mycophenolate mofetil in GVHD
OTHER DEPARTMENTS
ivb
Classifieds
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BLOOD, 20 NOVEMBER 2014 x VOLUME 124, NUMBER 22