codrina irena mihaela ancuta - cv - Universitatea de Medicina si

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Curriculum vitae | Codrina Irena Mihaela ANCUTA
CURRICULUM VITAE
Nume si prenume: ANCUTA Codrina Irena Mihaela
Nume anterior casatoriei: CHIRIEAC
Locul si data nasterii:
Adresa:;
Date contact:
Stare civila:
Pozitie profesionala si academica actuala
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medic primar specialitatea Reumatologie;
medic primar specialitatea Recuperare Medicala, Medicina Fizica si Balneologie;
doctor in medicina;
sef lucrari univ Disciplina Reumatologie-Balneofizioterapie, Departamentul Medicale II,
Universitatea de Medicina si Farmacie “Gr.T.Popa” Iasi;
coordonator Centru EUSTAR 162
Loc de munca actual
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1Universitatea
de Medicina si Farmacie “Gr.T.Popa” Iasi, Facultatea de Medicina, Disciplina
Reumatologie – Balneofizioterapie (din 1995);
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2Spitalul
Clinic de Recuperare Iasi, Clinica Reumatologie II, sef clinica (din 2013);
Studii
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1984-1988: Liceul “Emil Racovita”, profil matematica-fizica; absolventa a promotiei iunie 1998,
diploma de bacalaureat seria E Nr.39358 (media generala examen bacaureat 9.62);
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1988-1994: Universitatea de Medicina si Farmacie “Gr.T.Popa” Iasi, Facultatea de Medicina;
absolventa a promotiei 1994, diploma de medic - doctor: diploma M nr. 041128; media generala
de promovare a anilor de studiu 9.98; media generala de licenta 9.99 (sesiunea sept 1994);
Titluri stiintifice
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Doctor in Medicina (seria E nr. 0002743) (ordin MEC nr 3824/03.05.2006);
titlul tezei: Miopatia inflamatorie in poliartrita reumatoida/ Inflammatory myopathy in
rheumatoid arthritis
conducator de doctorat: prof univ dr George Ioan Pandele;
1998-2005: doctorand, data sustinerii tezei de doctorat: 15 iulie 2005
Experienta in specialitate si locuri de munca relevante
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01.02.1995-02.10.1995: medic rezident specialitatea Pneumoftiziologie prin concurs
(OMS 2213/1994), Spitalul Clinic de Pneumoftiziologie Iasi
Reumatologie
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1996-1999: medic rezident in specialitatea Reumatologie (OMS nr. 715/27.03.1996), Clinica de
Reumatologie, Spitalul Clinic de Recuperare Iasi
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1999 -2003: medic specialist Reumatologie (OMS nr. 900/ 20.10.1999; medie 9.17), Clinica de
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din 2003: medic primar specialitatea Reumatologie (OMS nr. 846/ 12.09.2003; medie 9.66),
Clinica de Reumatologie, Spitalul Clinic de Recuperare Iasi
Recuperare Medicala, Medicina Fizica si Balneologie
1|P age
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1999-2002: medic rezident in specialitatea Recuperare, Medicina Fizica si Balneologie, Clinica de
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2002-2008: medic specialist Recuperare, Medicina Fizica si Balneologie (OMS
256/11.04.2002; media 9.33), Clinica de Reumatologie, Spitalul Clinic de Recuperare Iasi
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din 2008: medic primar specialitatea Recuperare, Medicina Fizica si Balneologie (OMS
1971/03.12.2008; media 10.00), Clinica de Reumatologie, Spitalul Clinic de Recuperare Iasi
nr
Experienta didactica si locuri de munca relevante
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2.10.1995-01.03.1999: preparator universitar prin concurs, Disciplina ReumatologieBalneofizioterapie, Universitatea de Medicina si Farmacie “Gr.T.Popa” Iasi
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05.03.1999-01.03.2004: asistent universitar prin concurs (decizia 2825/05.03.1999),
Disciplina Reumatologie-Balneofizioterapie, Universitatea de Medicina si Farmacie “Gr.T.Popa”
Iasi
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din 01.03.2004 - in prezent: Sef lucrari univ prin concurs, Disciplina ReumatologieBalneofizioterapie, Universitatea de Medicina si Farmacie “Gr.T.Popa” Iasi
Cursuri de formare medicala (nationale, internationale) si specializari
Nationale
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Curs Management Spitalicesc, Scoala Nationala de Sanatate Publica si Management Sanitar,
14.02-28.03.2008, Bucuresti, Romania (seria A, nr. 00331);
Supraspecializare in Boli osoase endocrino-metabolice (certificate de absolvire curs seria D,
Nr 0011216) martie-nov 2003, Iasi, Romania; Certificat de supraspecializare in Patologie osoasa
endocrino-metabolica seria C Nr. 013718
Curs Laser-terapie, 01.03-31.05.2001, Iasi, Romania, certificate de absolvire curs seria A, nr
0009588
Curs intensiv Metode moderne de tratament al copilului spastic, 21-23.09.2000, Bucureti,
Romania
Curs postuniversitar Algeziologie (durerea si tratamentul ei), 23.04-21.05.1999, UMF
“Gr,T.Popa” Iasi (certificat de absolvire seria B, nr 0003658)
Internationale
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Curs imagistica: Imagistica in bolile reumatice, 01 oct 2014, Bucuresti, Romania
3rd Annual Meeting of the Lupus Academy, 7-9 March 2014 Berlin, Germany
Pain Refresher Course, 2nd May 2013, Singapore
2nd SE Europe Course Systemic Lupus Erythematosus, 25.09.2013, Bucuresti, Romania
APLAR Musculoskeletal Ultrasound Course in Rheumatology, The 15th Congress pf the Asia
Pacific League of Associatios for Rheumatology, 10-14 Sept 2012, Dead Sea, Amman, Jordan
Al doilea Curs International de Ecografie Musculoscheletala sub patronaj stiintific EULAR, 8-10
martie 2012 Bucuresti, Romania
Workshop: Methodentransfer und neue knozepte rheumatologie, 2-4 Jun 2011, Chisinau, Moldova.
ISCD Clinician Bone Densitometry Course, 25-26 feb 2011, Bucharest, Romania.
ISCD and IOF FRAX Initiative: Interpretation and Use of FRAX in Clinical Practice, 11-13 nov 2010,
Bucharest, Romania.
Curs Internaţional de Osteoporoză cu Certificare în Osteodensitometrie, IOF-OsArt, 27-28 mai
2009, Sinaia, Romania.
6th RCRD International Workshop: Up-to-date in Rheumatology, 27-29 apr 2009, Bucharest,
Romania
The 1st Quantitative Ultrasound Densitometry Course, 3-4 july 2008, Bucharest & Iasi
Curs EUSTAR: Scleroderma Skin Scoring Course, 11 jul 2008, Cluj-Napoca, Romania
Academy of Rheumatology, 18-20 dec 2008, Cairo, Egipt
2|P age
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Program educational de armonizare a managementului PR precoce in concordanta cu
recomandarile EULAR- Eupera, Sanofi Aventis (Universitatea Paris VII Franta; platforma
electronica www.eupera.org)
Workshop New evidence-based pain control: oxycodone in severe somatic, neuropatic and visceral
pain, 23-27 March 2007, Paris, France
4th RCRD (Research Centre on the pathology and treatment of Rheumatic Disorder) International
Workshop: Outcomes in Rheumatology, 6-8 dec 2007, Bucharest, Romania (European Commission
FP6)
Musculoskeletal ultrasound course, 19-21 Jan 2007, Bucharest, Romania
Curs International de Osteoporoza cu Certificare in Osteodensitometrie, 11-14 apr 2007, ClujNapoca, Romania
14th EULAR Intermediate Sonography Course, 10-13 June 2007, Sitges, Barcelona, Spania (sub
patronaj stiintific EULAR) (bursa studiu EULAR);
1st RCRD International Workshop: Advanced Techniques in Bone Research, 28-30 sep 2006
Bucuresti, Romania
ISCD Bone densitometry Course, 29-30 sept 2006, Bucuresti, Romania
International Musculo-skeletal Sonography Course (EULAR, OSART), 13-16 apr 2005, Cluj-Napoca,
Romania
Advancing arthritis therapy: addressing patient needs, 4 Feb 2006, Seville Spain
9th EULAR Sonography Course (from introductory to advanced practical course on musculoskeletal
sonograhy), 9-12 Dec 2004, Paris, France (sub patronaj EULAR) (bursa de studiu EULAR);
1st European Course–Capillaroscopy and Rheumatic Diseases, 10-12 Sep 2004, Genova, Italy (bursa
EULAR);
John Humphrey International Course of Immunology on self-tolerance and self-recognition, 15-19
May 2000, Sinaia, Romania; (sub patronaj European Federation of Immunological Societies, RSI,
Romanian Society for Immunology – Iasi Branch)
6th EULAR Postgraduate Course in Rheumatology, 18-27 June 2000, Nice, Franta (sub patronaj
EULAR) (bursa de studiu EULAR);
30 aug-03 sep 1992, John Humphrey Course on Tumor Immunology, Iasi, Romania
Cursuri Good Clinical Practice (GCP)
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CME Program SCEPTER, Introduction to the Clinical Drug Development Process: ICH Good
Clinical Practice for Clinical Trial Sites, web-training, 04 Jan 2012
Quintiles Global Learning & Development, Introduction to the Clinical Drug Development
Process: ICH Good Clinical Practice for Clinical Trial Sites, web-training, 03 Jan 2012
Pfizer GCP for Investigational Site Staff, Pfizer Partner Learning Solution, web-training, 11 feb
2011
FLEX-LA294 Investigator Meeting, 28029 apr 2011, Barcelona, Spain
Membru al asociaţiilor si organizatiilor profesionale (nationale, europene)
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Internationale: EUSTAR (EULAR Scleroderma Trials and Research); IASP (International
Association for the Study of Pain) si SIG musculoskeletal pain (subgroup durere musculoscheletala); ECTS (European Calcified Tissue Society); EMEUNET; Autoimmunity network
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Nationale: Societatea Romana de Reumatologie; Asociatia de Recuperare Nord Est
(membru fondator; 2009); RHEUMA-NORD EST – asociatie profesionala reumatologie
(presedinte si membru fondator; 2014); Colegiul Medicilor din Romania (CMI
2409/05.10.2011)
Limbi de circulatie internationala cunoscute
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Engleza – nivel B2 (atestat EuroEd, certificat absolvire nr 019/05 dec 2010; certificat de
absolvire Funny English center Curs avizat de Ministerul Invatamintului nr 25410/18.03.1997 si
Autorizat Consiliul National de Formare a Adultilor decizia 22/240 din 11.04.2008);
3|P age
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Franceza (nivel B2; atestat DALF- Diplome Approfondi de la Langie Francais 12/04/1995 – no
04000100097)
Membru în colectivele de redacție ale revistelor de specialitate, in consiliul peer-review
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Membru in Colegiul de Redactie al Revistei Romane de Reumatologie
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Invited peer-reviewer pentru reviste cotate ISI (Clinical Rheumatology, European Journal of
Physical and Rehabilitation Medicine);
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Membru consiliul peer-review al Revistei Romane de Reumatologie (Editura Medicala Amaltea,
Bucuresti; ISSN: 1843-0791; eISSN: 2069-6086, Cod CNCSIS: 378, B+)
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Invited peer-reviewer pentru reviste BDI (Journal of Dentistry, Medicine and Medical Sciences);
Premii si distinctii
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Premiu de Excelenta in Reumatologie, Societatea Romana de Reumatologie pentru lucrarea
Model matematic de predicție a obținerii remisiunii SDAI în poliartrita reumatoidă, Trifan
AE, Pomîrleanu C, Miu S, ANCUTA C, comunicare orala la CNR 2014 Bucuresti, Romania;
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Diploma de merit, lucrarea Terapia cu Infliximab si sarcina – o provocare a etapei moderne, Cardei M,
ANCUTA C, Ancuta E, Stoica S, Zugravu G, Chirieac R, Sesiunea comunicari orale Simpozionul Conect
2008 – Remicade la puterea a 6-a, 30 mai 2008, Bucuresti, Romania;
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Mentiune lucrarea Infliximab, eficacitate si tolerabilitate in artropatia psoriazica, ANCUTA C
et al, sesiunea postere, Simpozionul Conect 2008 – Remicade la puterea a 6-a, 30 mai 2008,
Bucuresti, Romania;
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Premiul de excelenta in medicina TNL, Gala Tinerilor valori editia IV, 24 feb 2009, Iasi, Romania
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Recunoastere in Marquis Who's Who; Ancuta Codrina Mihaela Irena is recognized in Marquis
Who's Who. : physician, educator, Location: Iasi; Country: Romania;
http://bios.marquiswhoswho.com/ancuta_codrina_mihaela_irena/physician_educator/8309281
Activitate didactica, cercetare stiintifica si clinica/ de asistenta medicala (vezi Lista
completa de lucrari anexata)
Activitatea profesionala desfasurata in cadrul UMF “Gr.T.Popa” Iasi si in Clinica Reumatologie, Spitalul
Clinic de Recuperare Iasi (integrare cu ½ norma) s-a conturat pe trei directii principale, respectiv
didactica, de cercetare stiintifica si activitatea clinica. O sinteza a acestor coordonate releva urmatoarele:
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articole publicate in extenso in reviste cotate ISI: (30) (11 articole in calitate de autor
principal; 19 articole coautor) (vezi lista completa lucrari anexata);
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articole publicate in rezumat in reviste cotate ISI: (86) (42 autor principal, 44 coautor) (vezi
lista completa lucrari anexata);
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articole in extenso in reviste indexate in BDI: (85) (39 autor principal, 46 coautor) (vezi lista
completa lucrari anexata);
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articole in rezumat in reviste indexate in BDI sau volume manifestari stiintifice cu si fara
ISBN: (76) (39 autor principal, 37 coautor) (vezi lista completa lucrari anexata);
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carti, manuale, monografii: carte internationala (4 capitole); carte nationala (1 editor, 4
autor unic, 1 membru in colectiv de autori, 13 autor capitol); (vezi lista completa lucrari anexata)
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participare la manifestari stiintifice internationale si nationale: (201 prezentari) (75
comunicari orale, 126 postere): international (4 autor principal si 20 coautor), national (25 autor
principal si 26 coautor) (comunicari orale); international (44 autor principal si 37coautor)
national ( 23 prim autor, 22 coautor) (postere); (vezi lista completa lucrari anexata)
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lector la manifestari stiintifice: 110 manifestari nationale (vezi lista completa lucrari anexata)
4|P age
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granturi/contracte de cercetare/ studii multicentrice: granturi internationale (14) (2
director de grant; 2 director partener national in consortiu international; 10 membru in colective
internationale); granturi nationale (4) (membru in echipa grant); studii multicentrice
postmarketing (14) (4 investigator principal in studii internationale; 10 investigator principal
in studii nationale); studii multicentrice randomizate (53) (9 investigator principal; 44 –
subinvestigator/coordonator de studiu)
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citari in articole: (272) (254 ISI, 18 BDI)
Articolele/studiile in extenso in reviste din fluxul stiintific international principal si BDI, publicatiile in
rezumat, participarile cu comunicari orale sau postere la manifestari stiintifica internationale si nationale,
activitatea editoriala se regasesc punctate in lista completa de lucrari.
Granturi/contracte de cercetare/ studii multicentrice
Director grant international (2)
1.
IASP Grant: Musculoskeletal pain academy, 2011, IASP Developing Countries Project: Initiative for
improving pain education; jul2011-jul2012; (acord UMF “Gr.T.Popa” Iasi nr.12119/28.06.2011);
finantare IASP 7000 USD; http://www.iasp-pain.org/Education/Content.aspx?ItemNumber=954;
http://www.musculoskeletal.pain-academy.com
Proiectul este focusat pe aspectele multivalente ale durerii musculo-scheletale, cu interpretare
interdisciplinara, atat din perspectiva specialistului in reumatologie, cat si a particulatilor de definire a
durerii in contextul sarcinii ce survine la o pacienta cu patologie reumatismala (prezentand punctul de
vedere a obstetricianului), a patologiei musculo-scheletale ce se dezvolta la practicianul stomatolog.
2.
EUSTAR Clinical Project CP34: Early Accelerated Atherosclerosis in Systemic Sclerosis (SSAS), grant
EUSTAR 2011-2015; UCN-EUSTAR162 (nr.12428/30.06.2011) membri echipa cercetare: Carmen
Marina Mihai, UMF Bucuresti (UCN-EUSTAR 100); Valeria Ricerri, Jose Luis Rosales-Alexander (UCNEUSTAR 094), Patricia Carreira P (UCN-EUSTAR 023), Maria Joao Salvador (UCN-EUSTAR 068), Juan
José Alegre Sancho (UCN EUSTAR 123); http://www.eustar.org/ClinicalTrial.html
Colaborarea multicentrica raportat la clarificarea profilului ATS accelerate in sclerodermia sistemica, cu
explorare complexa (biomarkeri surogat biologici si imagistici), in dinamica doar pentru subgrupul de
pacienti cu incadrare nationala, cu insertie de asemenea interdisciplinara; date preliminare prezentate in
analiza subgroup UCN EUSTAR 162 la congrese internationale; lucrare prezentata la Congresul National
de Reumatologie oct 2014, Bucuresti, Romania
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ANCUTA C, Pomirleanu C, Belibou C, Grosu C, Mihai CM, Magda SL, Carreira P, RosalesAlexander JL, Ricerri V, Salvador MJ, Chirieac R, Surrogate biomarkers for subclinical
atherosclerosis in systemic sclerosis: an interim analysis of the SSAS cohort, Revista
Romana de Reumatologie 2014, XXIII (supliment): 78;
Director partener national in consortiu international (2)
1.
EULAR Orphan Disease Program Observational study of treatment outcome in early diffuse
cutaneous systemic sclerosis; Chief Investigator Professor Ariane Herrick (University of Manchester);
Funder EULAR Orphan Disease Program (Funding Reference Number R111788); Acord colaborare
nr. 13517/14.07.2011 Universitatea Manchester-U.M.F. “Gr.T.Popa” Iasi (jul2011-ian2014); director
proiect UMF Iasi: dr. ANCUTA Codrina; finantare EULAR ODP 312 EURO/patient; 17 pacienti
inrolati (5300 Euro); http://www.ssc-esos.net/home.asp; http://www.eular.org/ (activitatea site UMF
Gr.TPopa Iasi – al treilea ca si activitate de recrutare a pacientilor SSc in cadrul proiectului de
cercetare)
2.
International EU-funded Research Project (FP7): DEsschipher, to decipher the optimal
management of systemic sclerosis, http://www.eustar.org/desscipher.html ; http://www.unigiessen.de/fbz/fb11/institute/klinik/rheumatologie/desscipher-en?set_language=en ; https://www.unigiessen.de/fbz/fb11/institute/klinik/rheumatologie/desscipher-en/about-desscipher/contributingcenters/contributing-centers
5|P age
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OT 1: Prevention and treatment of digital ulcers, Marco MATUCCI-CERINIC (UNIFI), Francesco
DELGADO (LEEDS), NCT01836263;
http://clinicaltrials.gov/ct2/show/NCT01836263?term=desscipher&rank=5
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OT2: Improvement of hand dysfunction by arthritis, principal investigator László CZIRJÁK,
NCT01834157, http://clinicaltrials.gov/ct2/show/NCT01834157?term=desscipher&rank=2
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OT3: Prevention and treatment of interstitial lung disease (lung fibrosis), principal investigator
Gabriela RIEMEKASTEN (CHARITÉ), Christopher DENTON (UCL), NCT01858259;
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OT4: Development and prevention of pulmonary hypertension, principal investigators: Yannick
ALLANORE, Jérôme AVOUAC (UPD), NCT01840748;
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OT5: Development and prevention of severe heart disease, PI: Gabriele VALENTINI (UNINA2),
NCT01829126, http://clinicaltrials.gov/ct2/show/NCT01829126?term=desscipher&rank=3
Proiect de cercetare castigat si finantat prin program European FP7, ambitios prin dezvoltarea
multicentrica, pe 5 directii de studiu, vazand afectarea viscerala cu relevanta vitala si impact
functional si asupra calitatii vietii, aflat in stadiul de recrutare a pacientilor pe teme de interes.
Membru in colectiv international (10)
1. IASP Grant IASP Developing Countries Project: Initiative For Improving Pain Education - Grant IASP
(International Association for the Study of Pain); Manager de proiect dr. Jaba Irina 05.2009-05.2010;
http://www.iasp-pain.org/Education/Content.aspx?ItemNumber=954
acord
UMF
Iasi
8499/20.05.2009; finantare IASP 9700 USD
Publicare ghid practic de terapie a durerii cronice – participare cu doua capitol - primul cu
insertie cai patofiziologice, metode de cuantificare si terapie farmacologica a durerii cronice
msculocheletale, cel de-al doilea cu raportare la terapia fizicala si de reabilitare
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ANCUTA C. Durerea cronica musculo-scheletala. In: Mungiu OC, Jaba IM (ed) Managementul durerii –
ghid practic (grant IASP: Initiative for Improving Pain Education), Editura “Gr.T.Popa”, UMF Iasi 2010,
ISBN: 978-973-7682-98-7 (pg 113-142);
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ANCUTA C, Managementul non-farmacologic al durerii cronice musculo-scheletale. In: Mungiu
OC, Jaba IM (ed) Managementul durerii – ghid practic (grant IASP: Initiative for Improving Pain
Education), Editura “Gr.T.Popa”, UMF Iasi 2010, ISBN: 978-973-7682-98-7 (pg 206-210);
2. PROTOCOL QUEST-RA 2009-2011: Quantitative Patient Questionnaire Monitoring in Standard
Clinical Care of Patients with Rheumatoid Arthritis (QUEST-RA), Manager de proiect Tuulikki SOKKA
(Finland), 2009-2011 (grant cu finantare internationala si locala Abbvie)
3. PROTOCOL QUEST-RA 2013-2014: Treating Rheumatoid Arthritis to Target: Are Recommendations
met? A Multinational Study of Patients with Rheumatoid Arthritis who Receive Usual Care in 33
Countries; Manager de proiect Tuulikki SOKKA (Finland), 2013-2014 (aviz nr 6680/01.04.2013)
(grant cu finantare internationala si locala Abbvie)
Protocol de studiu complex, cu incadrare multinationala (33 tari) si multicentrica, cu o cuantificare atat
de moment (pacienti consecutivi) a normelor de practica cotidiana in poliartrita reumatoida cu
specificitate nationala, dar si cu evaluare in dinamica (vizite predefinite in cadrul studiului), cu raportare
la recomandarile T2T formulate de EULAR.
Pt protocoalele 2 si 3, rezultatele au fost diseminate in cadrul manifestari EULAR si ACR, dar si prin
numeroase publicatii in fluxul international ISI. Intre acestea, participarea directa in:
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Grøn et al, The association of fatigue, comorbidity burden, disease activity, disability and gross
domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in
the Quest-RA program. Clinical and Experimental Rheumatology [2014] (PMID:25327997); Clin Exp
Rheumatol. 2014 Nov-Dec;32(6):869-77. Epub 2014 Oct 20 IF=2.973;
http://europepmc.org/abstract/med/25327997;; http://www.ncbi.nlm.nih.gov/pubmed/25327997
6|P age
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Khan NA, ANCUTA C, Patient's global assessment of disease activity and patient's assessment of
general health for rheumatoid arthritis activity assessment: are they equivalent? Ann Rheum Dis.
2012 Dec;71(12):1942-9. doi: 10.1136/annrheumdis-2011-201142. Epub 2012 Apr 24. IF=9.11;
http://ard.bmj.com/content/71/12/1942.short
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Khan NA, ANCUTA C, Determinants of discordance in patients' and physicians' rating of rheumatoid
arthritis disease activity. Arthritis Care Res (Hoboken). 2012 Feb;64(2):206-14. doi: 10.1002/acr.20685.
IF=4.039; http://onlinelibrary.wiley.com/doi/10.1002/acr.20685/full
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Sokka T, QUEST-RA. Work disability remains a major problem in rheumatoid arthritis in the 2000s:
data from 32 countries in the QUEST-RA study. Arthritis Res Ther. 2010;12(2):R42. doi: 10.1186/ar2951.
Epub 2010 Mar 12.; IF=4.357; http://www.ncbi.nlm.nih.gov/pubmed/20226018
Participare in 6 protocoale in colaborare multinationala multicentrica EUSTAR in cadrul UCN EUSTAR
162, si anume:
4. EUSTAR Project CP18: Digital Ulcers secondary to Systemic sclerosis AC-052-513 - grant EUSTAR
Research group and Actelion EUSTAR (Project leader: Prof. Ulrich Walker; Actelion Project leader:
Monika Brand; Project manager: Dr Rebecca Hollaender) (Nov 2009 – Oct 2010);
http://www.eustar.org/ClinicalTrial.html
5. EUSTAR Clinical Project: Very Early Diagnosis of Systemic Sclerosis VEDOSS, 2010-2015 (2020), ,
PROJECT manager: prof dr. Marco Matucci Cerinic ; aviz nr. ; http://www.eustar.org/Vedoss.html
(6681/01/04.2013)
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Minier et al (EUSTAR co-workers), Preliminary analysis of the Very Early Diagnosis of Systemic
Sclerosis (VEDOSS) EUSTAR multicentre study: evidence for puffy fingers as a pivotal sign for
suspicion of systemic sclerosis. Ann Rheum Dis. 2014 Dec;73(12):2087-93. doi: 10.1136/annrheumdis2013-203716. Epub 2013 Aug 12.; IF=9.270; http://www.ncbi.nlm.nih.gov/pubmed/23940211
6. EUSTAR
Clinical
12528/10.07.2009)
Project:
MEDS;
http://www.eustar.org/MedsOnline.html
(aviz
nr
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Meier et al EUSTAR Co-authors. Update on the profile of the EUSTAR cohort: an analysis of the EULAR
Scleroderma Trials and Research group database. Ann Rheum Dis. 2012 Aug;71(8):1355-60. doi:
10.1136/annrheumdis-2011-200742. Epub 2012 May 21.; IF=9.111;
http://www.ncbi.nlm.nih.gov/pubmed/22615460
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Elhai M et al (EUSTAR co-authors), A gender gap in primary and secondary heart dysfunctions in
systemic sclerosis: a EUSTAR prospective study. Ann Rheum Dis. 2014 Oct 23. pii: annrheumdis-2014206386. doi: 10.1136/annrheumdis-2014-206386. [Epub ahead of print]; . IF=9.27;
http://ard.bmj.com/content/early/2014/10/31/annrheumdis-2014-206386.short

Maurer B et al, EUSTAR co-authors. Prediction of worsening of skin fibrosis in patients with diffuse
cutaneous systemic sclerosis using the EUSTAR database. Ann Rheum Dis. 2014 Jun 30. pii:
annrheumdis-2014-205226. doi: 10.1136/annrheumdis-2014-205226. [Epub ahead of print]; IF=9.27;
http://ard.bmj.com/content/early/2014/07/07/annrheumdis-2014-205226.short;
http://www.ncbi.nlm.nih.gov/pubmed/24981642
7. EUSTAR Clinical Project IMPRESS 2: International Multi-centric Prospective study on pregnancy in
systemic sclerosis, Directori proiect: Monika Ostensen University of Trondheim Norway, Angela
Tincani University of Brescia Italy, Antonio Brucato, Ospedale Reuniti Bergamo Italy. oct 2013; aviz
19616/07.10.2013
8. EUSTAR Clinical Project CP11: Prevalence and clinical associations of capillaroscopic scleroderma
patterns in the EULAR Scleroderma Trial And Research group (EUSTAR) database of patients with
systemic sclerosis. Project Francesca Ingegnoli, (EUSTAR UCN 110), 2011;

Ingegnoli F et al (EUSTAR co-authors), Nailfold capillaroscopy in systemic sclerosis: data from the
EULAR scleroderma trials and research (EUSTAR) database. Microvasc Res. 2013 Sep;89:122-8. doi:
10.1016/j.mvr.2013.06.003. Epub 2013 Jun 17.; IF=2.432
http://www.sciencedirect.com/science/article/pii/S0026286213000939
7|P age
9. EUSTAR Clinical Project CP14: Biologics in systemic sclerosis patients treated with Rituximab. If you
have SSc patients treated with Rituximab; PI O Distler, UCN 006, Zurich;

Jordan S, Distler JH, Maurer B, Huscher D, van Laar JM, Allanore Y, Distler O; on behalf of the EUSTAR
Rituximab study group. Effects and safety of rituximab in systemic sclerosis: an analysis from the
European Scleroderma Trial and Research (EUSTAR) group. Ann Rheum Dis. 2014 Jan 17. doi:
10.1136/annrheumdis-2013-204522. [Epub ahead of print]; . IF=9.270;
http://ard.bmj.com/content/early/2014/01/17/annrheumdis-2013-204522.short
10. PROTOCOL IRIS: International Recommendation Implementation Study – a multinational
observational study to investigate the impact of recent treatment recommendations for the treatment of
patients with rheumatoid arthritis using web-based patient monitoring (METEOR); primary
investigator Robert B.M. Landewé (22.05.2013)
Protocol international de monitorizare a pacientului cu PR in cadrul recomandarilor T2T si insertie in
registru electronic, cu potential de dezvoltare a multiple publicatii in conditiile analizei
multidimensionale a bolii raportat la activitate, calitatea vietii, practice terapeutice.
Membru colectiv national (4)
1. GRANT CNCSIS: Platforma de cercetari fizio-farmacologice si clinice asupra mecanismelor
durerii oncologice si non-oncologice; cod CNCSIS 68; Contract 11/15.09.2006; 2006-2008; director
proiect OC MUNGIU (membru in echipa de cercetare) (finantare CNCSIS) in cadrul Centrului pentru
Studiul si Terapia Durerii de la Universitatea de Medicina si Farmacie "Grigore T. Popa” Iasi;
http://www.umfiasi.ro/Cercetare/CentreDeCercetare/Pages/default.aspx
http://www.algezio.ro/categorie/Cercetare_025/PLATFORMA_DE_CERCETARI_FIZIOFARMACOLOGI
CE_SI_CLINICE_ASUPRA_MECANISMELOR_DURERII_NONONCOLOGICE_SI_ONCOLOGICE_%28Cod_CN
CSIS:_68%29_078.html
proiect de cercetare cu finantare CNCSIS, ce a pus bazele cercetarii aprofundate in domeniul durerii
musculoscheletale, cu predilectie durerea inflamatorie, colaborarii interdisciplinare; puncte de reper:
infiintarea Centrului de Algeziologie Clinica, achizitie VICON, aparat de analiza computerizata a
biomecanicii mersului; grup de studiu dezvoltat ulterior cu activitate si in prezent pe durerea
inflamatorie din boala reumatismala cu determinsm imun si insertia terapiei biologice in acest
context (sub coordonarea subsemnatei); diseminare rezultate manifestari stiintifice si publicatii ISI;
2. PROIECT POSCCE-A2-O2.2.1-2007-1+Capacitati-I-2007-2, IMPACT IV sesiunea Sept 2007:
Centru de cercetare a lupusului eritematos sistemic si bolilor autoimune inrudite (CCLESAI),
2007-2008, proiect finantat (ID 1071); director proiect prof Chirieac R; (director stiintific in
echipa proiectului) http://www.poscce.research.ro/ro/articol/1737/fonduri-structurale-istoricimpact-sesiune-impact-iv-septembrie-2007
3. POSCCE A2-O2.2.1-2009-4 Operatiunea 2.2.1 Centru de cercetare a lupusului eritematos
sistemic si bolilor autoimune inrudite, Director stiintific, http://www.finantare.ro/stire-15020Rezultate-preliminare-evaluare-competitia-POS_CCE-A2_O221-_-2009.html
(proiect depus la
competitia mentionata urmarind dezvoltarea infrastructurii de cercetare pe domeniul lupusului
eritematis sistemic; desi punctajul obtinut a situat proiectul intre cele admise, cu un scor egal pentru
4 dintre acestea, nu a beneficiat de finantare)
4.
PROIECT POSDRU 81/3.2/S/55648, Formare profesionala pentru implementarea noilor
tehnologii in sistemul de sanatate PERFORMED, director proiect – prof dr HD Bolosiu, UMF I
Hatieganu Cluj-Napoca, 2010-2013, competitie, fonduri 5.000.000 EURO (realizarea si prezentarea
cursuri, Sesiunea de formare NE, http://performed.ro/; http://performed.ro/simpozioane/sesiuneade-formare-8-nord-est-iasi-10-13-septembrie-2013/
Studii multicentrice, PMOS si de faza II-III (randomizate, controlate)
8|P age
Investigator principal PMOS: nationale (4), internationale (10), si trialuri randomizate
(9)
1.
PROTOCOL ML25228 REPEAT: Studiu observational post-marketing cu Mabthera prescris pacientilor TNFIR, pentru evaluarea eficacitatii si sigurantei curelor repetate in practica medicala clinica de rutina
(Repeated Courses in routine Clinical Practice) (2012-2013) sponsor Roche
2.
PROTOCOL ML25332 STONE: Studiu observational post-marketing cu Ro-actemra (tocilizumab) prescris
pacientilor DMARD-IR pentru evaluarea eficacitatii si sigurantei adminstrarii in practica clinica de rutina;
sponsor Roche (2009-2011)
3.
PROTOCOL ML27953 FAST2 SWITCH: Studiu non-interventional prospective multicentric pentru a evalua
eficacitatea si siguranta rituximab la pacienti cu artrita reumatoida active care au avut un raspuns inadecvat
sau intolerant la un agent anti-TNF (2011) sponsor Roche
4.
Protocol ELOCVENT – Evaluarea impactului osteoporozei postmenopauza asupra calitatii vietii pacientelor
– studiu observational sponsor Servier; 04.2008-07.2008
5.
PROTOCOL BEL115014 SESAME: Systemic Lupus Erythematosus in CEE Settings: Romania, Poland,
Hungary. An insight on Medical, Economic and Social Burden (2011-2012); sponsor: GSK.
6.
PROTOCOL P10-599: An observational study of the impact of the anti-cyclic citrullinated peptide antibody
(anti-CCP) status on the management of patients with early rheumatoid arthritis (study HU-08-02): a multicountry, multi-center, post-marketing observational study in the routine clinical use (2010-2011); sponsor:
Abbott.
7.
PROTOCOL P10-919 EviraEAST: Evaluation of clinical outcome, treatment compliance and tolerability of
Humira (adalimumab) in patients with active Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing
Spondylitis in Eastern European countries: a multi-country, multicenter post-marketing observational study
in routine clinical use (2009-2011) (PMOS-CE-08-01); sponsor: Abbott.
8.
PROTOCOL PMOS P10-733 DEXA: Evaluation of the Role of Adalimumab on extra-articular manifestationbone metabolism and bone mineral density in patients with active Rheumatoid Arthritis (2011-2012) (centre
42146); sponsor: Abbott.
9.
PROTOCOL P12-768: Multi-country post-marketing observational study on maintenance of effectiveness of
adalimumab (Humira) in patients with ankylosing spondylitis and psoriatic arthritis – a multi-country
observational study in routine use in Central and Eastern Europe (nov 2011-2012 ); sponsor Abbott;
10. PROTOCOL P13-682 IDEA: Impactul adalimumab (Humira) ca terapie asupra utilizării anumitor resurse
legate de îngrijirea sănătății și asupra concediului medical la pacienții cu spondilită anchilozantă, în practica
clinică curentă (2012-2014), sponsor Abbott;
11. PROTOCOL P13‐683 PACE: Evaluarea activitatii fizice la pacientii cu poliartrita reumatoida tratati cu
adalimumab in practica clinica de rutina (PACE)- studiu observational postmarketing, multinational,
multicentric privind practica curentă în Europa Centrală și de Est (2012-2014); sponsor Abbott;
12. PROTOCOL IMM11-0138 ALIGN: Epidemiological/HEOR Study– Multi-country, cross sectionAL study to
determine patient specIfic and General beliefs towards medicatioN and their treatment compliance to
selected systemic therapies in chronic inflammatory diseases (IMID) (2012-2013); sponsor Abbott;
13. PROTOCOL 10297 PROOF: Pacienţi cu spondiloartrită axială: registru multi-naţional al caracteristicilor
clinice, inclusiv progresia radiologică, şi al poverii bolii pe parcursul a 5 ani în condiții reale (2014-2019);
sonsor Abbvie;
14. PROTOCOL IMM-12-0118: Evaluation of management of patients with early rheumatoid arthritis (RA)
in routine clinical practice based on Treat to Target (T2T) principles, (2014-2015), sponsor Abbvie
15. PROTOCOL IM 128-027: Studiu de faza 2 multicentric randomizat dublu orb controlat placebo de evaluate
a sigurantei si eficacitatii BMS-913699 vs placebo adminstrat pe fondul standardelor de ingrijire
restrictionat, ca tratament al subiectilor cu lupus eritematos sistemic active; sponsor Bristoll Myers Squibb
International Corporation Belgia; Investigator Principal (2014)
16. PROTOCOL A3921187 (9002-0249): A Phase 3b/4 randomized double blind study of 5 mg of Tofacitinib
with and without Methotrexate in comparison to Adalimumab with Methotrexate in subjects with moderately
to several active rheumatoid arthritis. Investigator principal (2014)
9|P age
17. PROTOCOL G0-VIBRANT. COD CNTO148PSA3001 A multi-centric, randomized, double blind placebo
controlled trial of golimumab, an anti TNF monoclonal antibody, administered intravenously, in subjects with
active psoriatic arthritis. Phase3. Investigator principal (2014)
18. PROTOCOL G0-ALIVE. COD CNTO148AKS3001 A multi-centric, randomized, double blind placebo
controlled trial of golimumab, an anti TNF monoclonal antibody, administered intravenously, in subjects with
active ankylosis spondylitis.Phase3. Investigator principal (2014)
19. PROTOCOL GLASS: A multi-center, randomized double-blind parallel group study on the therapeutic efficacy
and safety of febuxostat (taken once daily) and the therapeutic efficacy and safety of allopurinol on serum
urate concentration in subjects suffering from hyperuricemia and gout (MEIN/11/FEN-Gou/001; CRO
InnoPharma SRL, Sponsor MIOL, 2014-2015
20. PROTOCOL A9391010: a phase 2, randomized, double blind assessment of efficacy and safety of pf04171327 (1, 5, 10, 15 mg dose, daily) compared to 5 mg and 10 mg prednisone daily and placebo daily in
subjects with rheumatoid arthritis over an 8 week period followed by a 4 week period of tapering of study
drug; intermediar; Parexel; sponsor: Pfizer; Investigator principal (2014)
21. PROTOCOL B1801315: A randomized, double-blind placebo-controlled study of the maintenance of efficacy
of etanercept plus DMARD(s) compared with DMARD(s) alone in subjects with rheumatoid arthritis after
achieving an adequate response with etanercept plus DMARD(s); CRO: Parexel; sponsor: Pfizer Investigator
principal (2013)
22. PROTOCOL AB 06012: A phase 2b/3 study to evaluate efficacy and safety of masitinib in comparison to
methotrexate in patients with active rheumatoid arthritis with inadequate response to methotrexate or to
any disease-modifying antirheumatic drug; CRO: HT Research RO; sponsor AB Science; Investigator
principal (2013)
23. PROTOCOL PRINT Study, TcLand: Validation study of RA-INF-Dx as multigene molecular in vitro blood test
intended to aid in the identification of patients with rheumatoid arthritis who are unlikely to shown an initial
response to infliximab and methotrexate combination therapy (”Predict non-response to Infliximab therapy
study”) (2011-2012); sponsor: TcLand Expression; CRO: Premier Research Investigator principal (2012);
Subinvestigator (membru in echipa proiectului) sau coordonator de studiu (44)
1.
PROTOCOL M12-965 EudraCT 2014-001471-31: Phase 2, Multicenter, Open-Label Extension (OLE) Study
with ABT-122 in Rheumatoid Arthritis Subjects Who Have Completed the Preceding M12-963 Phase 2
Randomized Controlled Trial (RCT) Subinvestigator (2014-in desfasurare); sponsor Abbvie; (Investigator
principal prof Chirieac R) (adeverinta 2/05.01.2015)
2.
PROTOCOL EFC 10832: A randomized, double-blind, parallel, placebo-controlled study assessing the efficacy
and safety of sarilumab added to non-biologic DMARD therapy in patients with rheumatoid arthritis who are
inadequate responders to or intolerant of TNF-α antagonists; CRO: Covance; sponsor: Sanofi;
Subinvestigator (2013 – 2014); (Investigator principal prof Chirieac R) (adeverinta 6/05.01.2015)
3.
PROTOCOL CD-IA-MEDI-546-1013: A phase 2, randomized study to evaluate the efficacy and safety of
medi-546 in subjects with systemic lupus erythematosus; CRO: INC Research; sponsor: Medimmune;
Subinvestigator (2013 – in desfasurare); (Investigator principal prof Chirieac R) (adeverinta
7/05.01.2015)
4.
PROTOCOL CNTO136ARA3002: A study of CNTO 136 (sirukumab), administered subcutaneously, in
patients with active rheumatoid arthritis despite disease-modifying antirheumatic drug (DMARD) therapy
(SIRROUND); CRO: Parexel; sponsor: Janssen; Subinvestigator (2013 – in desfasurare); (Investigator
5.
PROTOCOL RA 0055: A multi-center, randomized, double-blind, placebo-controlled study to evaluate the
efficacy and safety of certolizumab pegol in combination with methotrexate for inducing and sustaining
clinical response in the treatment of DMARD-naïve adults with early active rheumatoid arthritis; CRO:
Parexel; sponsor: UCB Subinvestigator (2013 – 2014); (Investigator principal prof Chirieac R) (adeverinta
9/05.01.2015)
6.
PROTOCOL I4V-MC-JADV a randomized, double-blind, placebo and active-controlled, phase 3 study
evaluating the efficacy and safety of baricitinib in patients with moderately to severely active rheumatoid
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arthritis who have had an inadequate response to methotrexate therapy; CRO: ICON; sponsor: Eli Lilly;
Subinvestigator (2013 – in desfasurare); (Investigator principal prof Chirieac R) (adeverinta
10/05.01.2015)
7.
PROTOCOL I4V-MC-JADY: a phase 3, multicenter study to evaluate the long-term safety and efficacy of
baricitinb in patients with rheumatoid arthritis; CRO: ICON; sponsor: Eli Lilly; Subinvestigator (2013 – in
desfasurare); (Investigator principal prof Chirieac R) (adeverinta 11/05.01.2015)
8.
PROTOCOL H9B-MC-BCDP: a phase 3, multicenter, open label study to evaluate the long-term safety and
efficacy of LY2127399 in patients with Rheumatoid Arthritis; CRO: Quintiles; sponsor Eli Lilly; 2012-2013;
Subinvestigator; (Investigator principal prof Chirieac R) (adeverinta 12/05.01.2015)
9.
PROTOCOL H9B-MC-BCDM: a phase 3, multicenter, randomized, double blind placebo controlled study to
evaluate the efficacy and safety of sc LY2127399 in patients with moderate to severe Rheumatoid Arthritis
who had an inadequate response to methotrexate therapy; CRO: Quintiles; sponsor: Eli Lilly;
Subinvestigator (2012-2013); (Investigator principal prof Chirieac R)
10. PROTOCOL H9B-MC-BCDT: a phase 3, multicenter, randomized, double blind placebo controlled study to
evaluate the efficacy and safety of sc LY2127399 in patients with Systemic Lupus Erythematosus; CRO:
Parexel; sponsor: Eli Lilly; Subinvestigator (2012-2013); (Investigator principal prof Chirieac R)
(adeverinta 13/05.01.2015)
11. PROTOCOL H9B-MC-BCDO: a phase 3, multicenter, randomized, double blind placebo controlled study to
evaluate the efficacy and safety of sc LY2127399 in patients with Rheumatoid Arthritis with or without
background of Disease Modifying Anti-Rheumatic Drug(DMARD) therapy; CRO: Quintiles; sponsor: Eli Lilly;
Subinvestigator (2012-2013); (Investigator principal prof Chirieac R) (adeverinta 14/05.01.2015)
12. PROTOCOL H9B-MC-BCDX: a phase 3b, multicenter, open-label study to evaluate the long-term safety and
efficacy of subcutaneous LY2127399 in patients with systemic lupus erythematosus (SLE) (illuminate-x); CRO:
Parexel; sponsor: Eli Lilly; Subinvestigator (2012-2013); (Investigator principal prof Chirieac R)
(adeverinta 15/05.01.2015)
13. PROTOCOL Novartis CAIN457F2306: A randomized double-blind placebo-controlled multicenter study,
Novartis, Subinvestigator (2012-2013); (Investigator principal prof Chirieac R)
14. PROTOCOL WA22762: A randomized, double-blind, parallel group study of the safety and effect on clinical
outcome of tocilizumab SC versus tocilizumab IV, in combination with traditional disease modifying antirheumatoid arthritis drugs (DMARDs), in patients with moderate to severe active rheumatoid arthritis; CRO:
Comac sponsor Hoffman La Roche, Sub-investigator, 2010 -2104; Subinvestigator(Investigator principal
prof Chirieac R) (adeverinta 16/05.01.2015)
15. PROTOCOL ENTRACTE: A clinical outcomes study to evaluate the effects of IL-6 receptor blockade with
tocilizumab (TCZ) in comparison with etanercept (ETA) on the rate of cardiovascular events in patients with
moderate to severe rheumatoid arthritis (RA);CRO: Quintiles; sponsor : Hoffmann-LaRoche, Subinvestigator,
(Investigator principal prof Chirieac R) (2012- in desfasurare) (adeverinta 17/05.01.2015)
16. PROTOCOL I4V-MC-JADA: A randomized, double blind placebo controlled, dose ranging, parallel group,
phase 2b study in patients with active RA on MTX background therapy spondor: Eli Lilly; CRO Parexel; Subinvestigator, 2010 - 2014 (Investigator principal prof Chirieac R) (adeverinta 18/05.01.2015)
17. PROTOCOL Protocol I1F-MC-RHAK: studiu faza II cu doze variabile, subcutanate multiple de LY2439821
(Ac anti IL-17) la pacienti cu artrita reumatoida activa care urmeaza tratament concomitent cu DMARD;
sponsor: Eli Lilly; Sub-investigator, 2010 - 2013 (Investigator principal prof Chirieac R) (adeverinta
19/05.01.2015)
18. PROTOCOL A phase II, randomized, double-blind, controlled study to evaluate the immune responses, safety
and clinical efficacy of three doses of Neovacs’ TNF Kinoid in adult patients with rheumatoid arthritis who
have relapsed despite anti-TNF- biological therapy-sponsor Neovasc; CRO Genexion, Sub-investigator,
2010 - 2011
19. PROTOCOL P06129 GO-MORE: Un studiu cu design deschis (open-label),pentru a evalua adaugarea de
Golimumab Subcutanat (GLM) la terapia conventionala cu medicamente modificatoare de boala (DMARD) la
pacientii cu Artrita Reumatoida naivi la terapia biologica (Partea 1) urmata de un studiu randomizat ce
evalueaza valoarea terapiei combinate cu GLM administrat intravenous si subcutanat in scopul inducerii si
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mentinerii remisiunii(Partea 2); MSD, Sub-investigator, 2010 – 2012 (Investigator principal prof Chirieac
R) (adeverinta 20/05.01.2015)
20. PROTOCOL TRU-015-3206K1-2203-WW: a randomized, parallel, double-blind, placebo controlled dose
regimen finding study to evaluate the safety and efficacy of TRU-015 in subjects with active seropositive
Rheumatoid Arthritis on a stable background of methotrexate; sponsor & CRO: Wyeth; Sub-investigator,
2009-2011 ; (Investigator principal prof Chirieac R)
21. PROTOCOL A3921024: A long term, open label follow up study of CP-690.550, a moderately selective Janus
kinase 3 inhibitor, for treatment of Rheumatoid Arthritis. Sponsor & CRO: Pfizer; Sub-investigator, 2009-in
desfasurare (Investigator principal prof Chirieac R) (adeverinta 21/05.01.2015)
22. PROTOCOL RADAR: PROTOCOL P05320, Observational Trial on the value of diagnostic criteria in
the diagnosis of spinal spondylarthropathies in patients with chronic low back pain; Recognizing and
Diagnosing Ankylosing Spondylitis Reliably; sponsor MSD; Sub-investigator, 2009-2010 (Investigator
23. PROTOCOL BT971: studiu randomizat, controlat placebo, dublu orb cu esaladarea dozei pentru a evalua
eficacitatea, siguranta, si tolerabilitatea medicatiei de studiu BT971 la pacienti cu artrita reumatoida cu
tratament concomitent cu MTX; sponsor: Biotest AG Germany; CRO: IFE Romania, Sub-investigator, 20092010 ; (Investigator principal prof Chirieac R) (adeverinta 23/05.01.2015)
24. PROTOCOL H8C-MC-LQBG: A Phase 2 Study of the Effects of LY545694, an iGluR5 Antagonist, in the
Treatment of Subjects With Osteoarthritis Knee Pain; sponsor: Eli Lilly; Sub-investigator, 2008-2009;
(Investigator principal prof Chirieac R) (adeverinta 24/05.01.2015)
25. PROTOCOL WA20496: A randomized, double-blind, parallel group, international study to evaluate the
safety and efficacy of Ocrelizumab given as a single infusion or dual infusion compared with placebo in
patients with active Rheumatoid Arthritis who have an inadequate response to methotrexate therapy;
Sponsor: Hoffmann La Roche; CRO: Quintiles Romania; subinvestigator, 2008-2011; (Investigator
26. PROTOCOL ROB 803-09-002: a phase II, randomized, double-blind, multicenter placebo-controlled, doseranging, parallel study group to evaluate the efficacy and safety of orally administered Rob 803 when added
to stable MTX in patients with moderate or severe active Rheumatoid Arthritis; Sponsor: Oxypharma; CRO:
Pharm-Olam; Sub-investigator, 2008-2009 ; (Investigator principal prof Chirieac R) (adeverinta
26/05.01.2015)
27. PROTOCOL LJP 394-90-14: A randomized, double-blind, placebo controlled, three arm, parallel group,
multicenter, multinational safety and efficacy trial of 300 mg and 900 mg of Abetimus Sodium in SLE patients
with a history of renal disease; sponsor: La Jolla International; CRO: Pharm-Olam; subinvestigator, 20082009; (Investigator principal prof Chirieac R) (adeverinta 27/05.01.2015)
28. PROTOCOL WA20499: A randomized, double-blind placebo controlled parallel group multicenter study to
evaluate the efficacy and safety of two doses of Ocrelizumab in patients with active SLE; Sponsor: HoffmannLa Roche Ltd/ Genetech Inc; CRO: Quintiles Romania, subinvestigator, 2008-2009; (Investigator principal
prof Chirieac R) (adeverinta .01.2015)
29. PROTOCOL IP-004: studiu faza IIb, multicentric, randomizat, dublu orb, placebo-contolat pentru evaluarea
sigurantei, tolerantei si eficacitatii a doua doze de studiu IPP 201101 subcutanat plus terapia standard, in
comparatie cu placebo la pacientii cu LES; sponsor: Immupharma; CRO: Genexion; Sub-investigator, 20082009 ; (Investigator principal prof Chirieac R) (adeverinta 28/05.01.2015)
30. PROTOCOL A3921035: a phase II B, randomized, double blind, placebo controlled active comparator,
multicenter study to compare 5 dose regiments of CP-690.550 and adalimumab versus placebo, administered
for 6 months in the treatment of subjects with active Rheumatoid Arthritis. Sponsor & CRO: Pfizer, Subinvestigator, 2008-2009 ; (Investigator principal prof Chirieac R) (adeverinta 29/05.01.2015)
31. PROTOCOL D1520C00001: a randomized, double-blind (with open comparator Etanercept), placebocontrolled, phase IIB multicenter study to evaluate the efficacy of 4 doses of AZD9056 administered for 6
months on the signs and symptoms of Rheumatoid Arthritis in patients with active disease receiving
background MTX or Sulphasalasine; sponsor: Astra-Zeneca; CRO: Verum; Sub-investigator, 2008-2009 ;
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32. PROTOCOL MDX 1100-04: a phase II, multi-dose, double-blind, placebo controlled, randomized, multicenter
study of MDX-1100 (anti CXCL 10 Human Monoclonal Antibody) in patients with active Rheumatoid Arthritis;
sponsor: Medarex; CRO: PSI Pharma; Sub-investigator, 2008-2009; (Investigator principal prof Chirieac
R) (adeverinta 31/05.01.2015)
33. PROTOCOL ACT5488: Activity and safety of oral administration of SSR150106XB for the reduction of
inflammation in patients with active rheumatoid arthritis; :a 4 week, multicenter, randomized, double-blind,
placebo-controlled parallel group study of 90 mg administered once daily and 90mg once every other day;
Sponsor Sanofi-Aventis; CRO: I3 research; subinvestigator, 2007-2008; (Investigator principal prof
Chirieac R) (adeverinta 32/05.01.2015)
34. PROTOCOL P04422: A randomized, multicenter, international open label study of infliximab plus
methotrexat versus methotrexat alone for the treatment of methotrexate naive subjects with active psoriatic
arthritis; sponsor & CRO: Schering Plough Central East AG; faza IV; subinvestigator, 2007-2008;
35. PROTOCOL: A phase 2 multicenter randomized double-blind placebo-controlled parallel-group dose finding
study of the safety and efficacy of daily CF101 administered orally when added to weekly methotrexate in
patients with active rheumatoid arthritis; Sponsor Can-fite Bio-Pharma Ltd; CRO: Pharm Olam
International; subinvestigator 2006-2007; (Investigator principal prof Chirieac R) (adeverinta
37/05.01.2015)
36. PROTOCOL WA17047: A randomized, phase 3, controlled, double-blind, parallel-group, multicenter study to
evaluate the safety and efficacy of rituximab in combination with methotrexat compared to methotrexate
alone, in methotrexat –naïve patients with active rheumatoid arthritis; Sponsor: Hoffmann-La Roche
Genentech; CRO: Parexel, subinvestigator 2006-2010; (Investigator principal prof Chirieac R) (adeverinta
36/05.01.2015)
37. PROTOCOL P1-0205: Efficacy and safety of FASU1 versus FASU2 in a 180 day study treatment in patients
with osteoarthritis of the knee; Sponsor Laboratoires Expascience; CRO: CRC Pharmaceuticals,
subinvestigator 2006-2007; (Investigator principal prof Chirieac R) (adeverinta 35/05.01.2015)
38. PROTOCOL F1J-MC-HMEP. Duloxetine 60 to 120mg versus placebo in the treatment of patients with
Osteoarthritis knee pain; sponsor si CRO: Eli Lilly Romania SRL; subinvestigator 2006-2007; (Investigator
principal prof Chirieac R)
39. PROTOCOL D1520C05287. A randomized double-blind, placebo-controlled, parallel group, ascending dose
study to assess the activity, safety and tolerability of 2 doses of AZD9056 for 4 weeks in patients with active
rheumatoid arthritis receiving methotrexate and/or sulphasalazine, phase II; sponsor Astra Zeneca; CRO
Parexel International SRL, subinvestigator, 2005-2006; (Investigator principal prof Chirieac R)
(adeverinta 34/05.01.2015)
40. PROTOCOL MDT3-005. A two-arm study comparing the analgesic efficacy and safety of Tramadol HCl oncea-day versus placebo for the treatment of pain due to osteoarthritis of the knee; CRO: Parexel International;
coordonator studiu, 2005-2006; (Investigator principal prof Chirieac R) (adeverinta 38/05.01.2015)
41. PROTOCOL H4Z-MC-GJAD. Effects of Arzoxifene on vertebral fracture incidence and on invasive breast
cancer incidence in postmenopausal; women with osteoporosis or with low bone density; Sponsor Ely Lilly
and Company; CRO: Quintiles Romania; subinvestigator, 2004-2009; (Investigator principal prof Chirieac
R) (adeverinta 39/05.01.2015)
42. PROTOCOL MI-CP100: A phase II, randomized, double -blind study to evaluate the effects of MEDI-522, a
humanized monoclonal antibody to integrin alpha V beta 3 on disease activity and progression of joint
damage in patients with active rheumatoid arthritis sub-optimally responding to methotrexat; sponsor
Medimmune; CRO: PSI Pharma Support Romania SRL; coordonator studiu, 2003-2004; (Investigator
principal prof Chirieac R)
43. PROTOCOL Studiu multicentric, de faza III, randomizat, asupra tolerabilitatii Tramadol la pacienti cu atroza
de genunchi; Parexel International, coordonator studiu, 2003-2004; (Investigator principal prof Chirieac
R)
44. PROTOCOL Studiu multicentric, de faza III, randomizat, dublu orb, placebo-controlat asupra tolerabilitatii
gastro-intestinale a combinatiei terapeutice diclofanac-misoprostol (ArthrotecR) la pacienti cu atroza de
13 | P a g e
genunchi; coordonator studiu, 1998-1999; (Investigator principal prof Chirieac R) (adeverinta
40/05.01.2015)
Burse de tip mobilitate pentru pregatire profesionala, obtinute prin competitie
(evaluarea CV, scrisoare de motivatie)

3rd Annual Meeting of the Lupus Academy, 7-9 March 2014 Berlin, Germany (bursa)

14th EULAR Intermediate Sonography Course, 10-13 June 2007, Sitges, Barcelona, Spania (bursa
studiu EULAR)

9th EULAR Sonography Course (from introductory to advanced practical course on musculoskeletal
sonograhy), 9-12 Dec 2004, Paris, France (bursa de studiu EULAR);

1st European Course–Capillaroscopy and Rheumatic Diseases, 10-12 Sep 2004, Genova, Italy (bursa
EULAR);

6th EULAR Postgraduate Course in Rheumatology, 18-27 June 2000, Nice, Franta (sub patronaj
EULAR) (bursa de studiu EULAR);
Lucrari de diploma indrumate: 74 lucrari licenta Facultatea de Medicina (42 licenta in limba engleza);
14 lucrari indrumate Faculatatea Bioinginerie; 3 lucrari in dubla coordonare cu cadru didactic disciplina
Ergonomie, Facultatea Stomatologie (web-site-ul bibliotecii UMF “Gr.T.Popa” Iasi)
Proiecte educationale si de formare medicala continua

IASP Grant: Musculoskeletal pain academy, 2011, IASP Developing Countries Project: Initiative for
improving pain education; jul2011-jul2012; (acord UMF “Gr.T.Popa” Iasi nr.12119/28.06.2011);
finantare IASP 7000 USD; (coordonator international)

IASP Grant IASP Developing Countries Project: Initiative For Improving Pain Education - Grant IASP
(International Association for the Study of Pain); Manager de proiect dr. Jaba Irina 05.2009-05.2010;
(accord UMF Iasi 8499/20.05.2009); finantare IASP 9700 USD, membru in echipa

Cursuri postuniversitare EMC acreditate, Facultatea Medicina, UMF Gr.T.Popa Iasi –
Coordonator (6)
An universitar 2014/2015, http://www.umfiasi.ro/EMC/Documents/cursuri%20postuniversitare%2020142015/medicina%202014%202015.pdf
1. Sclerodermia sistematică (SS) – aspecte practice clinice şi terapeutice, 01.03-30.04.2015
An universitar 2010/2011 ( http://www.umfiasi.ro/EMC/EMC/EMC_Medicina_2010-2011.pdf)
2. Terapia biologica in boli inflamatorii cronice cu determinism imun, 1-31 mar 2011
3. Evaluare si monitorizare in bolile reumatismale inflamatorii cornice, 1-28 feb 2011
4. Sclerodermia sistemica (SS) – actualitati diagnostice si terapeutice, 1-30 apr 2011,
An universitar 2009/2010
5. Evaluare si monitorizare in bolile reumatismale inflamatorii cornice, 1-28 feb 2010
6. Sclerodermia sistemica (SS) – actualitati diagnostice si terapeutice, 1-30 apr 2010
Proiecte de educatie continua nationale (membru) (4)

PROIECT POSDRU 81/3.2/S/55648, Formare profesionala pentru implementarea noilor tehnologii
in sistemul de sanatate PERFORMED, director proiect – prof dr HD Bolosiu, UMF I Hatieganu ClujNapoca, 2010-2013, competitie, fonduri 5.000.000 EURO, membru cu participare directa in realizarea si
prezentarea cursuri, Sesiunea de formare NE, http://performed.ro/;
http://performed.ro/simpozioane/sesiunea-de-formare-8-nord-est-iasi-10-13-septembrie-2013/

Master UMF Gr.T.Popa Iasi, specializarea Boli cu determinism imun, coordonator prof. univ dr Rodica
Marieta Chirieac (mai 2006-dec 2007); lector;

Tulburari de crestere staturo-ponderala, coordonator prof dr. Corina Galesanu; lector; (syllabus ISBN
978-973-7682-11-6), curs postuniverstar acreditat UMF Iasi, An universitar 2006/2007
14 | P a g e

Boli osoase endocrine-metabolice; coordonator prof dr C Galeasanu; lector
Lector cursuri postuniversitare formare continua (23)
1.
Curs Osteoporoza (de la diagnostic la tratament) o provocare pentru practician, 28 feb-02 mar2013
Iasi, Romania, coordonator prof dr. Corina Galesanu; lector (Osteoporoza glucocorticoid indusa;
Osteoporoza la barbat)
2.
Curs postuniversitar (Rolul medicului de familie in diagnosticarea, monitorizarea si managementul
poliartritei reumatoide, Lector, Conferinta Zilele Spitalului Clinic de Recuperare 3-7 apr 2012,
3.
Conferinta Zilele Spitalului Clinic de Recuperare 3-7 apr 2012, Iasi, Romania; Manifestarile
cardiovasculare din bolile reumatismale imunoinflamatorii cronice: screening, diagnostic si management",
curs interdisciplinar Cardiologie-Reumatologie; lector (Hipertensiunea arteriala pulmonara in contextul
bolilor reumatismale: date epidemiologice, etiopatogenie, diagnostic clinic);
4.
Curs EMC: Urgențe reumatologice în practica clinică, Conferinta ”Zilele Spitalului Clinic de Recuperare”
(editia a IX-a), 22-27 mar 2011, Iasi, Romania: Impactul recuperarii asupra calitatii vietii; lector (Criza
renala sclerodermica)
5.
Curs postuniversitar: Dizabilitatea și calitatea vieții în bolile reumatismale cronice, Conferinta
“Zilele Spitalului Clinic de Recuperare” (editia a IX-a), 22-27 mar 2011, Iasi, Romania: Impactul recuperarii
asupra calitatii vietii. Lector (Poliartrita reumatoida, dizabilitatea si calitatea vietii)
6.
Curs postuniversitar Reumatologie, 15-16 apr 2010, Iasi, Romania. Coordonator prof Chirieac R;
lector (Evaluarea – clinica, functionala, de calitate a vietii in poliartrita reumatoida; Posibile ratiuni clinice
pentru ciclizarea tratamentului anti-TNF; switching si efecte adverse)
7.
Curs postuniversitar: Osteoporoza – boala cronica invalidanta. De la depistarea precoce la
tratament, 20 mar 2010, Iasi, Romania. Coordonator curs: prof Galesanu C, moderatori sesiune: prof
Galesanu C, prof Botez P; lector (Osteoporoza glucocorticoid indusa. Poliartrita reumatoida)
Curs postuniversitar: Osteoporoza – Aspecte teoretice si practice, Conferinta “Zilele Spitalului Clinic
de Recuperare” (editia a VII-a), 24-28 mar 2009, Iasi, Romania: Actualitati in preventia si recuperarea
medico-chirurgicala; coordonator prof dr. Rodica Chirieac; lector (Modalitati diagnostic in osteoporoza–
evaluarea DXA; Actualitati in managementul osteoporozei– medicatia antiosteoporotica cu actiune duala;
Actualitati in managementul osteoporozei – perspective terapeutice in osteoporoza; Monitorizarea terapeii
anti-osteoporotice
8.
9.
Curs postuniversitar: Performantele musculare si rolul in reeducarea functional din bolile
reumatismale, neurologice, cardio-vasculare, posttraumatice Conferinta “Zilele Spitalului Clinic de
Recuperare” (editia a VII-a), 24-28 mar 2009, Iasi, Romania: Actualitati in preventia si recuperarea medicochirurgicala; lector (Metode de reabilitare: metode electrice–stimularea electrica neuromusculara; Metode
de reabilitare: metode kinetoterapeutice – tehnici de facilitare; Particularitati ale muschiului si metode de
recuperare in boli reumatismale: poliartrita reumatoida, miopatii de tip inflamator, artroza)
10. Curs postuniversitar: Recuperarea medicala si reabilitarea – un act terapeutic de echipa;
coordonator: dr Gavrilas C. Manifestarea “Zilele Spitalului de Recuperare “Sf Gheorghe” Botosani”, 23-24
apr 2008, Botosani, Romania (editia I); Lector
Chirieac R, ANCUTA C, Tacu C, Gavrilas C, Recuperarea medicala si reabilitarea intre present si viitor, aspect ale
interdisciplinaritatii, Modul Recuperare; Rezus E, Chirieac R, ANCUTA C, Tacu C, Recuperarea soldului operat,
Modul Recuperare; ANCUTA C, Tacu C, Rezus E, Tehnici de facilitare in recuperare, Modul Recuperare; Rezus E,
Chirieac R, ANCUTA C, Tehnica exercitiului aerobic, modul Recuperare; Chirieac R, ANCUTA C, Gavrilas C, Evaluarea
clinica in poliartrita reumatoida si impactul pe reeducarea functionala, modul Reumatologie; ANCUTA C, Rezus E,
Gavrilas C, Evaluarea si monitorizarea tratamentului in bolile reumatismale inflamatorii cronice, modul
Reumatologie; Rezus E, Chirieac C, ANCUTA C, Evaluarea in osteoporoza, modul Reumatologie;Chirieac R, ANCUTA
C, Rezus E, Mecanismele durerii, modul Algeziologie; Rezus E, Chirieac R, ANCUTA C, Durerea din afectiunile
degenerative, modul Algeziologie; Ancuta Codrina, Chirieac R, Durerea de tip inflamator, modul Algeziologie
11. Curs postuniversitar: Bio-Care – terapie revolutionara in bolile autoimune: actualitati si
perspective (coordonator R. Chirieac), Conferinta “Zilele Spitalului Clinic de Recuperare Iasi, 20-22 mar
2008, Iasi, Romania; lector (Efecte adverse ale terapiei biologice. Infectia tuberculoasa – screening si
monitorizare; Terapia anti-CD20)
15 | P a g e
12. Curs postuniversitar: Actualitati in imunopatologia si terapia bolilor reumatismale cu determinism
imun, Conferinta “Zilele Spitalului Clinic de Recuperare Iasi” (editia a V-a), 29-31 mar 2007, Iasi, Romania;
lector
13. Curs postuniversitar: Exercitiu aerobic: implicatii teoretice si practice, Conferinta “Zilele Spitalului
Clinic de Recuperare Iasi” (editia a V-a), 29-31 mar 2007, Iasi, Romania; lector
14. Curs EMC: Managementul durerii in patologia reumatismala, 25 mai 2007, Iasi, Romania moderator
prof Chirieac R; Lector (Managementul durerii articulare in reumatismele inflamatorii
15. Curs EMC: 05 Dec 2007, Suceava, Romania; moderator prof Chirieac R; Lector, Terapii eficiente in
patologia musculoscheletala.
16. Curs postuniversitar: Terapia prin miscare. Aspecte fiziopatologice si practice, Conferinta “Zilele
Spitalului Clinic de Recuperare Iasi” (editia a IV-a), 6-8 apr 2006, Iasi, Romania;
R Chirieac, ANCUTA C, C Munteanu, Recuperarea aparatului musculo-scheletal; R Chirieac, L Macovei, I Boaru, C Tacu,
ANCUTA C, Parametrii fizici ai miscarii; R Chirieac, ANCUTA C, C Nacu, Metode practice de intretinere si recuperare a
miscarii: mobilitate, flexibilitate, ROM, posturari; ANCUTA C, C Tacu, Tehnici de facilitare
17. Curs EMC: Managementul bolii artrozice. Curs pentru depistarea, diagnosticarea precoce si
tratamentul bolii artrozice, 2006, Bacau, Romania. Lector, Terapia bolii artrozice si rolul coxibilor.
tratamentul bolii artrozice, 14 apr 2006 Suceava, Romania, lector, Boala artrozica – prezentare de caz
tratamentul bolii artrozice, 2006, Iasi, Romania, Lector, Boala artrozica – prezentare de caz
20. Curs EMC: Eficacitatea – obiectiv esential in tratamentul afectiunilor musculo-scheletale, 3 mar
2006, Iasi, Romania, coordonatori – prof dr. Chirieac R, ptof dr. Bolosiu H, lectori: Ionescu R, Balanescu A,
ANCUTA C, Rezus E, sarbu P
21. Curs EMC: Osteoporoza- o epidemie cu adevarat silentioasa?, 05 nov 2005, Iasi, Romania; moderator
Sirbu P, participant: Sirbu P, ANCUTA C (Fracturile vertebrale: cause declansatoare si preventia acestora),
Branisteanu D, Galesanu C (5 EMC)
22. Curs EMC: Patologia osteoarticulara la inceput de mileniu, 27 apr 2004, Iasi, Romania moderatori: prof
Chirieac R, Bolosiu H; ANCUTA C, Tratamentul biologic al afectiunilor cronice inflamatorii.
23. Curs EMC: Calitatea vietii virstnicului cu afectiuni musculo-scheletale, 26 nov 2003, Iasi, Romania,
moderator prof Chirieac R, lectori: prof Pandele G, conf Botez P, Rezus E, ANCUTA C (Caractere clinicopatogenice, terapeutice si calitatea vietii varstnicului cu poliartrita reumatoida).
Membru in comitete științifice, organizator de manifestări științifice (18)
1.
Organizator/coordonator Workshop – Poliartrita reumatoida – de la diagnostic la tratament – ANCUTA C,
Bojinca M, Ancuta I, Conferinta Zilele Spitalului Clinic de Recuperare Iasi, 25-29 mar 2014, Iasi, Romania,
2. Organizator/ coordonator Workshop, Artropatiile microcristaline: o noua abordare patogenica, diagnostica
si terapeutica, Conferinta Zilele Spitalului Clinic de Recuperare Iasi, 25-29 mar 2013, Iasi, Romania
3. Comitet de organizare Conferinta Zilele Spitalului Clinic de Recuperare Iasi, 26-29 mar 2013, Iasi, Romania
4. Comitet de organizare/ Coordonator modul Reumatologie II: Autoimunitatea la pacientul varstnic:
particularitati de diagnostic si terapie; Conferinta Zilele Spitalului Clinic de Recuperare Iasi – editia XI, 26-29
mar 2013, Iasi, Romania
5. Comitet de organizare Conferinta Zilele Spitalului Clinic de Recuperare Iasi, 3-7apr 2012, Iasi, Romania
6. Congresul Roman de Reumatologie 23-26 nov 2011; Brasov, Romania
7. Comitet de organizare Congresul Roman de Reumatologie, 19-22 oct 2010, Brasov, Romania
8. Comitet de organizare Conferinta Zilele Spitalului Clinic de Recuperare Iasi (editia a VIII-a), 23-27 mar 2010,
Iasi, Romania
9. Comitet de organizare Conferinta Zilele Spitalului Clinic de Recuperare Iasi (editia a VII-a), 24-28 mar 2009,
Iasi, Romania
10. Comitet de organizare Coferinta Zilele Spitalului Clinic de Recuperare Iasi, Editie aniversara 30 ani, 20-22
martie 2008
11. Congresul National de Reumatologie cu participare internationala, 14-17 sep 2005, Brasov, Romania
16 | P a g e
12.
13.
14.
15.
Conferinta Zilele Spitalului Recuperare 27-29 mar 2003, Iasi, Romania
Conferinta Nationala de reumatologie cu participare internationala, Iasi, 28-30 mai 1998
Consiliul stiintific al XXI-lea Congres National de Reumatiologie, 1-4 Oct 2014, Bucuresti
Comitet stiintific Conferinta Zilele Spitalului Clinic de Recuperare Iasi editia a XII-a, 25-29 Martie 2014,
Iasi, Romania
16. Comitet stiintific al XX-lea Congres National de Reumatologie 25-28 sept 2013, Bucuresti,
17. Comitet stiintific – Zilele Spitalului de Recuperare Sf Gheorghe Botosani, editia 1, 23-24 apr 2008, Botosani,
Romania
18. Secretar stiintific Congresul National OSART, 14-17 mai 2008, Iasi, Romania
Brevete de inventie: 2 internationale (vezi lista completa de lucrari anexata)
Evaluare activitate didactica si cercetare anuala – in primele 10 locuri din universitate in
ultimii 3 ani (http://www.umfiasi.ro/Pages/Default.aspx)
Nume si adrese contact personalitati din domeniu pentru recomandare
Professor Ariane HERRICK, professor of Rheumatology, University of Msnchester, UK, Telephone +44
(0)161 275 5993; Email: [email protected] (recomandare atasata)
Prof univ dr. Mioara BANCIU, Email: [email protected], mobil 0744925789Timisoara, Romania
(recomandare atasata)
Prof univ dr. Maria SUTA, Email: [email protected]; mobil: 0723213019, Constanta, Romania
Conf univ dr. Denisa PRESETEANU, Email: [email protected]; mobil 0723640548, Bucuresti, Romania
Prof univ dr Laurentiu MOGOANTA, Email: [email protected], Craiova, Romania,
Prof univ Eugen CARASEVICI, Iasi, Romania, Email: [email protected]
Prof univ dr Minodora MAZUR, Chisinau, Moldova, email: [email protected]
Prof univ dr Liliana GROPPA, Chisinau, Moldova, email: [email protected]
17 | P a g e
Recunoasterea contributiilor stiintifice: (272 citari) (254 citari in reviste cotate ISI)
Adresa web pt citari: http://scholar.google.ro/scholar?start=50&q=codrina+ancuta&hl=ro&as_sdt=0,5
http://scholar.google.ro/scholar?q=ancuta+c&btnG=&hl=ro&as_sdt=0%2C5
Articol citat: A phase II, randomized, double‐blind, placebo‐controlled study evaluating the efficacy and safety
of MDX‐1100, a fully human anti‐CXCL10 monoclonal …, …, H LeBlanc, G Nichol, C Ancuta… - Arthritis & …,
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B cells as therapeutic targets in SLE, I Sanz et al, Nature Reviews Rheumatology, 2010 - nature.com,
Chemokines: established and novel targets in atherosclerosis, RR Koenen et al, EMBO molecular medicine,
2011 - embomolmed.embopress.org
Innovative therapies for systemic sclerosis, VH Ong, CP Denton, Current opinion in rheumatology, 2010 journals.lww.com
Trial Watch, L Zitvogel, G Kroemer - 2012 - landesbioscience.com, [HTML] from nih.gov (CITARE BDI)
CXCL10 and its receptor CXCR3 regulate synovial fibroblast invasion in rheumatoid arthritis, T Laragione et
al, Arthritis & …, 2011 - Wiley Online Library
Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in
rheumatoid arthritis, D Hammaker et al, Rheumatology, 2012
B cell therapies for rheumatoid arthritis: beyond B cell depletion, I Calero et al, Rheumatic Disease Clinics of
North America, 2010 – Elsevier
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of
Chemokine Receptors and Introducing a New Nomenclature for …, F Bachelerie et al, Pharmacological …,
2014 – ASPET,
Rheumatoid arthritis therapy: advances from bench to bedside, SI Choi, E Brahn, Autoimmunity, 2010
Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study, L Mayer et al, Gut,
2014
Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll‐like receptor 3
stimulation, AE Østvik et al, Inflammatory bowel …, 2012 - Wiley Online Library
Chemokine (C–X–C motif) ligand (CXCL) 10 in autoimmune diseases, A Antonelli et al, Autoimmunity …, 2014
– Elsevier
The interaction between CXCL10 and cytokines in chronic inflammatory arthritis, EY Lee, ZH Lee, YW Song Autoimmunity reviews, 2013 – Elsevier
Targeting chemokines and chemokine receptors with antibodies, A Klarenbeek et al, Drug Discovery Today:
…, 2013 – Elsevier
Liver X receptor regulates rheumatoid arthritis fibroblast-like synoviocyte invasiveness, matrix
metalloproteinase 2 activation, interleukin-6 and CXCL10, T Laragione, PS Gulko, Molecular Medicine, 2012
Monoclonal antibody against CXCL-10/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury,
W Wang et al, Cell …, 2013 - ncbi.nlm.nih.gov, [HTML] from nature.com
Safety and Efficacy of the Newer Biological Therapeutics in the Treatment of Rheumatoid Arthritis, V
Navarro-Compán… - Clinical Medicine Insights …, 2011
Emerging therapies for rheumatoid arthritis, P Jacques, F Van den Bosch, Expert opinion on emerging …,
2013
Prolonged TNFα primes fibroblast‐like synoviocytes in a gene‐specific manner by altering chromatin, C Sohn
et al, Arthritis & …, 2014 - Wiley Online Library
Review: new anti-cytokines for IBD: what is in the pipeline?, M Scharl, SR Vavricka, G Rogler, Current drug
targets, 2013 - ingentaconnect.com
The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis, DL Boyle et al,
Annals of the …, 2014 - ard.bmj.com
Перспективы фармакотерапии ревматоидного артрита: моноклональные антитела, ЕЛ Насонов, ЛН
Денисов… - Научно-практическая …, 2012 - cyberleninka.ru
Thymidine Phosphorylase Regulates the Expression of CXCL10 in Rheumatoid Arthritis Fibroblast‐like
Synoviocytes, Y Toyoda et al, Arthritis & …, 2014 - Wiley Online Library
Chemokines and chemokine receptors blockers as new drugs for the treatment of chronic obstructive
pulmonary disease, G Caramori et al, Current medicinal …, 2013 - ingentaconnect.com
Brief Report: Inadequate Description and Discussion of Enrolled Patient Characteristics and Potential Inter–
Study Site Differences in Reports of Randomized …, S Yurdakul et al, Arthritis & …, 2014 - Wiley Online
Library
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26. Targeting Chemokine (CXC motif) Receptor 3 in Thyroid Autoimmunity, P Fallahi et al, Recent patents on …,
2014 - ingentaconnect.com
27. Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by
suppressing HDAC5 expression, C Angiolilli et al, Annals of the …, 2014 - ard.bmj.com
28. Novel treatment options for ulcerative colitis, BP Vaughn, AC Moss - Clinical investigation, 2013 - Future
Science
29. Anti-inflammatory drimane sesquiterpene lactones from an Aspergillus species, S Felix et al,
Bioorganic & medicinal chemistry, 2014 – Elsevier
30. World Journal of Pharmaceutical ReseaRch, K Sekhri, R Nandha, S Aditya - 2014 - wjpr.net
31. The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis, DL Boyle et al,
Annals of the …, 2014 - ard.bmj.com
32. Перспективы фармакотерапии ревматоидного артрита: моноклональные антитела, ЕЛ Насонов, ЛН
Денисов… - Научно-практическая …, 2012 - cyberleninka.ru
33. Thymidine Phosphorylase Regulates the Expression of CXCL10 in Rheumatoid Arthritis Fibroblast‐like
Synoviocytes, Y Toyoda et al, Arthritis & …, 2014 - Wiley Online Library
34. Chemokines and chemokine receptors blockers as new drugs for the treatment of chronic obstructive
pulmonary disease, G Caramori, A Di Stefano, P Casolari… - Current medicinal …, 2013 - ingentaconnect.com
35. Brief Report: Inadequate Description and Discussion of Enrolled Patient Characteristics and Potential Inter–
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Study Site Differences in Reports of Randomized …, S Yurdakul, BN Mustafa, I Fresko… - Arthritis & …, 2014 Wiley Online Library
Targeting Chemokine (CXC motif) Receptor 3 in Thyroid Autoimmunity, P Fallahi, S Martina Ferrari, A
Corrado… - Recent patents on …, 2014 - ingentaconnect.com
Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by
suppressing HDAC5 expression, C Angiolilli, AM Grabiec, BS Ferguson… - Annals of the …, 2014 ard.bmj.com
Current and prospective pharmacotherapy for autoimmune hepatitis, AJ Czaja - Expert opinion on
pharmacotherapy, 2014 - informahealthcare.com
The Role of CXCR3 in DSS-Induced Colitis, B Chami, AWS Yeung, C van Vreden, NJC King, S Bao - PloS one,
2014 - dx.plos.org
Role of CXCL10 in central nervous system inflammation, D Michlmayr, CS McKimmie - International Journal
of Interferon, …, 2014 - dovepress.com
Therapeutic effect of anti-CXC motif chemokine 10 (CXCL10) antibody on C protein-induced myositis mouse, J
Kim, JY Choi, SH Park, SH Yang… - Arthritis research & …, 2014 - biomedcentral.com
CXCR3 ligands in disease and therapy, K Van Raemdonck, PE Van den Steen… - Cytokine & Growth …, 2014 –
Elsevier
Review article: chemokines as orchestrators of autoimmune hepatitis and potential therapeutic targets, AJ
Czaja - Alimentary Pharmacology & Therapeutics, 2014 - Wiley Online Library
Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis, D Michlmayr, JK
Lim - Frontiers in cellular neuroscience, 2014 - ncbi.nlm.nih.gov
MAbs Targeting Soluble Mediators in Phase 1 and 2 Clinical Studies Immunological Disorders, FR Brennan Handbook of Therapeutic Antibodies - Wiley Online Library
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05 IAN 2015
CODRINA ANCUTA
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