Isoflavones

I s o f lavo nes :
The Difference Is in the Ratio
Colacurci, N., Zarcone, R., Borrelli, A., De Franciscis, P.,
Fortunato, N., Cirillo, M., Fornaro, F. Effects of soy
isoflavones on menopausal neurovegetative symptoms.
Minerva Ginecol. 2004 Oct;56(5):407-12.
Iso flav o nes: The Difference Is in the Ratio
Crisafulli, A., Marini, H., Bitto, A., Altavilla, D.,
Squadrito, G., Romeo, A., Adamo, E.B., Marini, R.,
D’Anna, R., Corrado, F., Bartolone, S., Frisina, N.,
Squadrito, F. Effects of genistein on hot flushes in early
postmenopausal women: a randomized, double-blind
EPT- and placebo-controlled study. Menopause. 2004
Jul-Aug;11(4):400-4.
FUNCTIONAL
FOODS
NUTRITION BARS
PERSONAL CARE
SOYFOODS
VITAMINS
Soy Isoflavone
Concentrates Made
from Whole Soybeans
vs. Soy Germ
Scambia, G., Mango, D., Signorile, P.G., Anselmi Angeli,
R.A., Palena, C., Gallo, D., Bombardelli, E., Morazzoni, P.,
Riva, A., Mancuso, S. Clinical effects of a standardized soy
extract in postmenopausal women: a pilot study.
Menopause. 2000 Mar-Apr;7(2):105-11.
BENEFITS OF ISOFLAVONES
• Clinical studies consistently show that soy
isoflavones like Novasoy lower the incidence of
hot flashes.
• In fact, researchers say soy isoflavones like
Novasoy are a natural alternative for reducing
menopausal symptoms like hot flashes.
What Are Isoflavones?
Isoflavones are natural plant nutrients that exhibit agonist and antagonist estrogenic mechanisms. Genistein
and daidzein are two isoflavones found in soybeans. In
fact, they’re the isoflavones found in the highest
amounts in soybeans, and those that provide the most
powerful benefits for people.
Though many different isoflavones exist, the primary types in soy are genistein, daidzein, and
glycitein. These are also the primary isoflavones found
in Novasoy brand soy isoflavones.
• Soy isoflavones may also affect arterial health.
Preliminary research suggests that soy
isoflavones may help keep arteries flexible,
and healthy arteries contribute to a healthy
cardiovascular system.
For customers around the world, ADM draws on its resources—its people, products, and market
perspective—to help them meet today’s consumer demands and envision tomorrow’s needs.
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SUPPLEMENTS
N
ot all soy isoflavone concentrates
are created equal. Although whole soybean-derived and soy germ-derived products
do contain the same individual isoflavones, their
isoflavone ratios are significantly different. The concentrates that show the greatest benefits are those
which, like Novasoy® brand soy isoflavones, are
extracted to maintain an isoflavone ratio close to the
whole soybean.
Why should you buy whole soybean isoflavone concentrates like Novasoy? Read on, and learn why the
difference is in the ratio.
Upmalis, D.H., Lobo, R., Bradley, L., Warren, M., Cone,
F.L., Lamia, C.A. Vasomotor symptom relief by soy
isoflavone extract tablets in postmenopausal women: a
multicenter, double-blind, randomized, placebo-controlled
study. Menopause. 2000 Jul-Aug;7(4):236-42.
© 2005 Archer Daniels Midland Company
&
BEVERAGES
Han, K.K., Soares, J.M. Jr., Haidar, M.A., de Lima, G.R.,
Baracat, E.C. Benefits of soy isoflavone therapeutic regimen
on menopausal symptoms. Obstet Gynecol. 2002
Mar;99(3):389-94.
ADM Natural Health and Nutrition
N UTRITION
800-510-2178
[email protected]
Isoflav ones:
G E N I S T E I N E Q U I VA LE N C E
S OY
20
15
Recommended Minimum Dose
10
5
Compare the ratio of genistein, daidzein, and
glycitein in tofu and soy germ to the ratio in
isoflavone concentrates like Novasoy®:
0
140 mg SoyLife® 40%
FPO
140 mg Soyselect® 15%
Where Are Isoflavones
Found?
140 mg Novasoy® Brand Soy Isoflavones 40%
C O M PA R I S O N O F I S O F L AVO N E
P H Y TO E S T R O G E N C O N T E N T S
S O M E F O O D I T E M S (mg/kg as is)
AN D
Food Item
Soybeans
(dry)
Novasoy brand soy isoflavones
1.3 : 1 : 0.3*
Tofu
1.3 : 1 : 0.3
Soy germ
0.3 : 1.1 : 1
*genistein:daidzein:glycitein
In our diets, soy is the primary source for isoflavones,
though you’ll also find them in mung beans, red
clover, alfalfa sprouts, kudzu*, chickpeas, and other
plant foods.
Soy isoflavone concentrates such as Novasoy® have
a natural ratio much like the one found in foods such
as tofu, which is made from whole soybeans and
recognized as a smart meal choice.
OF
The Difference Is in the Ratio
The Whole Soybean
vs. Soy Germ
A whole soybean is much higher in genistein forms
than soy germ, a common source for isoflavone concentrate. Soybeans typically contain 0.1% isoflavones,
predominantly in glucoside derivatives. That includes
at least 50% genistein, about 40% daidzein, and up to
10% glycitein forms.
In contrast, soy germ isoflavone products typically
contain about 40% daidzein, 40% glycitein, and 20%
genistein forms.
Coumestrol+ Formononetin Biochanin A
Daidzein
Genistein
466
738
0.5
0.7
0.1
Green beans
(fresh)
ND
ND
ND
1.5
Trace
Lima beans
(dry)
0.2
0.1
15
0.1
ND
Garbanzo
beans (dry)
0.4
0.6
ND
7
16.1
Pinto beans
(dry)
0.1
2.6
18
Trace
3
Clover
sprouts
ND
4
281
23
4
Alfalfa
sprouts*
ND
ND
23.4
1305
ND
ND=not detected
Lentils
ND
ND
ND
0.1
ND
Source: USDA, Iowa State University Database on the
Isoflavone Content of Foods, Release 1.2 - 2000
*Neither red clover nor kudzu contain
appreciable amounts of genistein.
Coumestrol is not an isoflavone but a coumestan
+
Soy isoflavone concentrates like Novasoy, which
originate from whole soybeans, provide greater benefits due to their high concentration of genistein forms.
Through a proprietary process, we extract Novasoy
brand soy isoflavones to closely match the natural
isoflavone ratios of soybeans and unfermented
soyfoods.
The Power of a Soy Pioneer
Beyond Novasoy soy isoflavones, ADM is a soyfoods
innovator. Our portfolio includes a wide range of naturally derived ingredients designed to provide food
processors functionality and high performance in a
variety of applications.
With vast knowledge and experience, our global
R&D team works closely with customers to provide
application, formulation, and technical support. In
our state-of-the-art pilot plants, laboratories, and culinary facilties, we create real-world solutions to new
challenges every day.
N OVA S OY ® B R A N D
I S O F L AVO N E C O N C E N T R AT E
Isoflavones (min.)
in the glucoside form
40%
Ratio of genistein,
daidzein, glycitein forms
1.3 : 1 : 0.3
Other natural soy
phytocomponents (typical)
41%
Protein N x 6.25
7 to 12%
Ash (max.)
4%
Moisture (max.)
6%
Appearance
Fine powder