Ideas, Inspiration and Innovation in WA
Transcription
Ideas, Inspiration and Innovation in WA
> Kevin’s saw is a cut above the rest You could safely describe Kevin Inkster’s brick and mortar saw – the Allsaw – as a cutting edge product. It’s a revolutionary saw that can cut bricks and wood – but not a person’s arm. Which is just one of the reasons the petrol version of it was the overall winner at the 2008 Inventor of the Year Awards. Inkster’s Perth-based company Arbortech has developed and made numerous successful woodworking and power tools over the past 25 years. The electric version of the Allsaw – sold as the AS170 brick and mortar saw – runs off mains power and utilises the company’s patented cutting technology of two blades moving in a small elliptical orbit at high frequency. Inkster came up with the idea for a safer saw after he cut his hand with a chainsaw nearly 30 years ago. It’s proving popular around the globe. “We make the electric version here and distribute it around the world,” Inkster says. “The major markets for us are the United States, England and Europe and Australia. Australia is extremely good for us. “We’ve also developed a new cutting technology, called the Hammersaw, which uses a single blade and is capable of cutting concrete as well as rebar (the reinforcing steel) not just brick and masonry – which is raising the bar even more. “And it looks like we will be able to do the concrete version ourselves.” But it’s not all plain sailing. One thing that’s proving elusive for the moment is producing a petrol version of the Allsaw. Ideas, inspiration and innovation in WA Disruptive technology Inkster and his team have run into what you could called the innovator’s Catch 22 – they’ve come up with a disruptive technology that is perhaps just too threatening for the global manufacturers of chainsaws. Inkster says he’s been told informally that coming up with a safer saw means that manufacturers’ inventories of normal chainsaws would, in effect, be regarded as ‘unsafe’ – and a legal nightmare if using them resulted in injuries. Inkster and his team is now facing the challenge of trying to source an appropriate high-end petrol motor for the petrol Allsaw, one that would meet European emissions standards and include special filtration to cope with masonry dust. Current off-the-shelf motors are too big and powerful and to customise motors from scratch would be prohibitively expensive without the help of major manufacturers. “I decided to develop the technology further and tackle the even greater problem of cutting concrete and rebar with a safe and effective alternative,” he says. “This has resulted in the Hammersaw which has huge advantages of safety and performance and is more easily adapted to regular rotary driven tools. This means that it is far easier for us to produce locally or license to other companies as it is less threatening to their existing markets.” Inkster is philosophical about the setback with the petrol Allsaw, which he sees as part of the problem-solving process. “I’ve come to understand one thing about innovations,” he explains. “I’ve heard many other inventors talk like this and they’re totally focused on all the reasons they can’t get something up and going because they encounter all kinds of resistance, and the resistance isn’t necessarily intentional. “If you’re in an industry and you’re the leader of that industry and you’re making a lot of money out of that industry, why do you want to invest millions of dollars in something that is going to ruin your income from that leading industry? Improvement “That’s very much the dilemma for them. “Sometimes it’s better to have an incremental improvement than to have something radically different. “What we’ve discovered is that with disruptive technology, you have to go all the way yourself. “So if we can get the petrol Allsaw up and going, then they have no choice but to follow suit.” Inkster says entering the WA Innovator of the Year Awards can provide a good reality check for inventors and innovators. “One of the best things that came out of it, believe it or not, was the video featuring us that was produced as part of the awards,” he explains. “That video served us so well in our negotiations with major companies.” With disruptive technology, you have to go all the way yourself. < > Big names of high-tech queue for the sequel to Fusion Books When Melanie Perkins and Cliff Obrecht started their online company Fusion Books and became finalists in the 2008 WA Inventor of the Year Award while still university students, little did they realise where it would lead. Now, five years later, they have some of the biggest names from the technology world — Google Maps, Yahoo! and Facebook — lining up to invest $3 million in seed funding for their newest online business. Melanie and Cliff founded Fusion Books as an easy-to-use online service that lets schools design and print eye-catching yearbooks. Melanie says hundreds of Australian high schools now use the service. “We’ve become the largest year book company in Australia and we’ve recently launched in France and New Zealand,” Melanie says. Building on that success, Melanie and her team are starting a new company, Canva, which is due to launch this year. “Canva takes the concept behind Fusion Books and applies it to a broader market,” says Melanie. She says being part of the Inventor of the Year Awards has opened more doors than she could have dreamed of. “At an IOTY lunch, Larry Lopez introduced us to an investor from Silicon Valley, Bill Tai. We only had a brief conversation, but I stayed in touch with him and kept him posted on our milestones,” she says. Fast-forward two years, and Tai invited Melanie and Cliff to MaiTai, an entrepreneur and kite boarding conference in Hawaii. Ideas, inspiration and innovation in WA “We met a number of investors and entrepreneurs at MaiTai, not only was their advice invaluable, a number have also become investors,” Melanie says. “One benefit has been the connections we made, that short chat with Bill Tai has had an incredible domino effect,” she says. Top Australian and US investors have invested in Canva including Matrix Partners, Blackbird Ventures, InterWest Partners and 500 Startups. “Also getting great advice in the early stages of our business had a huge impact on our strategies and success. Fledgling venture Other investors include Bill Tai; the director of engineering at Facebook, Lars Rasmussen; Yahoo! CFO Ken Goldman; and Seek co-founder Paul Bassat. As well as that, the fledgling venture has attracted a grant from Commercialisation Australia through its Early Stage Commercialisation program. Melanie was completing her Communications and Commerce degree at The University of Western Australia and teaching people how to use design programs when she came up with the idea for Fusion Books. “Students were struggling with the basics of how to use these programs – they were difficult to learn and complex to use. I realised that, in the future, design was going to be much, much easier,” she recalls. Melanie says her Inventor of the Year experience was invaluable. “My favourite quote is: ‘Persistence isn’t using the same tactic over and over, persistence is having the same goal over and over’. “I think that’s really applied to our story: know where you want to go and every day work towards that vision.” And her tip for people thinking of entering the Innovator of the Year Awards? “Network as much as you can, gather as much knowledge as you can, and then apply it all to your company,” she says. “It’s a fantastic program that’s had a huge impact on us – absolutely go for it.” Network as much as you can, gather as much knowledge as you can, and then apply it all to your company. < > ‘If you believe in your idea, they believe’ Hayley Warren was a determined second-year physiotherapy student when she came up with a new way to measure the angles of patients’ joints. Now, after five years of R&D and having won the Start Up category of the WA Innovator of the Year Awards in 2010, her invention is taking on the world. The HALO digital goniometer she developed uses laser technology to help physiotherapists and other health and sports professionals measure the angle of patients’ joints to assist recovery. Warren, who is now the CEO of Halo Medical Devices, says winning the IOTY award had an effect almost immediately. “The Innovator of the Year Award really brought about recognition for myself as an inventor and company owner and brought forward opportunities in terms of investors,” says Warren. “As a result of the awards, I met my first mentor who’s become an investor in the company, Nathan Buzza, who is heavily involved in the innovation medical device space. “And from winning the award, we also went on to win the Electronic News Future Award last year, the 40 Under 40 Award for entrepreneurs in WA, and we also won the People’s Choice award on the ABC’s New Inventors.” IOTY also helped Warren realise her goal of going global. In mid-March, her company HALO Medical Devices launched HALO in the United States. “We used the money from the award to progress to the stage now where we’re selling,” says Warren. Ideas, inspiration and innovation in WA “It boosted us through the development stage, making sure the foundations were set correctly – and what I mean by that is we had an opportunity to set up and protect the intellectual property because that was part of the award prize. “So it really laid the foundations to set us up for where we are today, which is launching the product globally.” HALO already has a healthy following locally. Strategically “It’s well recognised over here already,” she says. “It’s being used in the AFL by people such as the Eagles and some of the top hospitals in Perth as well.” The push into bigger markets is being tackled strategically. “We’re focused on Australia and the US for the time being,” she says. “Given the economic climate in Europe at the moment, the US makes more sense for us. “Having said that, we recently launched an email campaign in the United Kingdom, so we are branching into there but our focus is on the US and Australia.” Warren says HALO has been sent out to 15 leading universities and private companies worldwide for further product validation. Among them is the world-renowned Mayo Clinic based in the US. Entering the IOTY in 2010 meant that Warren had to acquire new skills quickly. “Coming from the small country town of Manypeaks near Albany, growing up on a farm and physio all had common ground, they all needed a practical approach,” she says. “That I do well. Getting up to do pitches and learning about financials, was very new to me, and had to be learnt. “That process of going through pitches and panels as part of the awards really did assist me. ‘Back yourself’ “It even shaped how I pitch to investors now and gave me the foundation to do that correctly and successfully bring in more money as the company’s needed it.” Warren’s advice for fellow inventors and innovators thinking of entering the Innovator of the Year Awards is to “back yourself”. “Unless you strongly believe in your idea, you’re not going to get anywhere,” she says. “It comes back to knowing why you’re doing it, knowing it’s a good idea – and following it through. “People tend to follow: if you believe, they believe.” Even if you don’t win the award, she says you’ll still come out in front in terms of the experience and contacts you make. “That’s one of the things I’ve found that works,” says Warren. “If you truly believe in what you’re doing and it’s a good idea, just follow it through no matter what it takes. There will be many hurdles; just tackle them one by one and you will get there.” ‘IOTY … really laid the foundations to set us up for where we are today, which is launching the product globally. < > Smartphone apps come to the aid of shoppers and drivers Consumers and retailers are getting smarter in the way they do things, partly due to technologies developed by Clinton House and his team at Inhouse Group. Clinton and Inhouse were finalists in the Start Up category of the 2011 WA Innovator of the Year Awards for having developed the hardware and software technologies. The first is Chirp Deals, a smartphone app that alerts people to discounts and special offers available at local shops and shopping centres. It might have started at the local level but it’s growing. “We are in the process of licensing the underlying technology of that application to a significant national organisation,” House says. The second technology, Inhouse Insights, monitors shoppers’ behaviour in retail centres and other environments, allowing centre managers real-time data on consumer behaviour. Since the IOTY awards, the company has also developed and launched a smartphone parking app for the City of Perth that lets drivers know which car parks in Perth have bays available, along with exactly how many they have. The relationship with the City of Perth has continued and House says the company is now seen as an innovation partner to the city. “When we launched that app, it was an Australian first for offering live bay availability, and we have other innovative projects with them that will be launched over the next few months,” House says. “But when you talk about technology of the sort that we entered in the awards, we got a lot of surprised looks that we came from Perth, because they assumed if you were an Australian into tech, you were in Sydney. There’s even international attention. “It was an interesting observation for us, that we were starting to get on the map for tech.” “We’re looking at partnerships to expand that with different hardware partners and different local governments and applications around the world now,” he says. Regional start House says the awards added to the company’s profile and credibility and has helped to attract investors. “It helped us raise our Series A funding so we didn’t have to sell too big a stake in the company to raise the required finances,” he says. “The process involving mentoring, pitch coaching and getting in front of judges was a baptism of fire for me. Being confident enough in your product and leaving the judging panel comfortable that you know what you’re talking about was a great experience,” he says. Inhouse is now based in King Street, Perth, but it started life as a regional business in Mandurah. “Being in front of those judges and answering their questions prepared me for pitching to investors where I raised our Series A funding. And a recent trip to the US to pursue opportunities in software technologies for the mining industry indicates it might just be helping to change perceptions. “You have to stand there on the spot and answer all the really difficult questions, and know your product and market better than the back of your hand. “When we mentioned we were from Perth they almost bow before you because Perth – or WA – is regarded as the centre for mining and resources in the world for some people,” House says. “Just for that alone, it was well worth entering.” “That was acknowledged and respected. Ideas, inspiration and innovation in WA House says if you have an innovation you want to pursue, it’s worth looking into entering the IOTY awards. You have to know your product like the back of your hand. < > Solving a well-known problem attracts miners’ attention Since winning the overall Innovator of the Year Award in 2011, Tim Jones and his colleagues at Intium Solutions have been fielding calls from all over. “We’ve had enquiries all around the world, from South America, Russia, North America, various parts of western Europe, and Indonesia,” says Jones, Intium’s managing director. “So word certainly gets around, particularly when the problem is well known and people are looking for a solution.” The ‘problem’ he’s referring to is how to detect conveyor belt rollers that are worn, wonky or likely to break down. “There’s a risk that when a roller fails it can turn into a ‘pizza cutter’, where the inner shell collapses and leaves sharp edges that can tear the belt up,” explains Jones. “Also, the bearings can seize and the roller stops and rubs on the belt, and that can damage the belt.” The problem’s bigger than you might think. In fact, it’s a real headache around the world. For instance, Australia’s mining industry uses an estimated 55,000 kilometres of conveyor belts to transport ores. “The belts can be up to 20 kilometres long in a single flight and companies put several flights together so there can be 20, 30 or 40 kilometres of conveyor,” explains Jones. Million-dollar delays Breakdowns can be incredibly expensive in terms of million-dollar delays, days of downtime and missed shipments. Intium’s solution was to come up with an innovative wireless sensor system – known as the Roller Condition Ideas, inspiration and innovation in WA Monitoring (RCM) system – to monitor the condition of rollers. “We have a wireless sensor that sits on every frame of a conveyor belt and takes a reading every two minutes,” says Jones. “It then sends this information off to a collector station which compiles information from about 400 sensors and then sends it back to us for processing. “What the customer ends up with is a real-time monitoring system that allows them to see what’s going on with any of their belts, automatically and remotely.” Since winning the Innovator of the Year Award, Intium Solutions has continued to refine the sensor system. “We were in a development trial with Alcoa, since then we’ve progressed to a commercial trial with a larger system,” Jones says. “We’ve also engaged with another major mining company in a commercial trial. “There are some very good results coming out of those trials and as a result we’re in the process of going to market. “We’ve also been in discussion with various potential partners in the market, such as large conveyor companies. They’ve been pretty receptive to the product.” Accolade The roller monitoring system has also picked up another accolade. “It was an Australian Bulk Handling award that came from the conveyor belt industry so we’re quite happy with that one. That was the icing on the cake after the Innovator of the Year award,” says Jones. “To us, that was validation from industry that we’re on the right track.” He says winning the Innovator of the Year Award helped give the project extra credibility in dealing with large companies. “So instead of being a little company that no one really knows about, we’re a little company that has received a major award and has been judged by a panel of industry experts. That’s given us quite a bit of credibility,” Jones says. “We’ve also had a lot of support and introductions from the WA Government and we’ve also had a lot of support from the major sponsor, Mitsubishi.” So what advice does he have for innovators thinking of entering the awards? “Obviously we think it’s well worth doing,” Jones says. “We got a lot out of it. But I think just going through the process is a benefit in itself. “What it forced us to do was really define what the innovation is and why it is of commercial benefit not just of technical benefit.” There is also another ongoing, perhaps less tangible, benefit. “There is a networking group called the Innovators’ Circle which is designed to bring together the winners and finalists from previous years, so that’s been of benefit to swap stories and share contacts and so on,” Jones says. “I think it’s a good way of building an ‘innovation alumni’.” What it forced us to do was really define what the innovation is and why it is of commercial benefit not just of technical benefit. < > Online video play idea pays off Some innovations seem so simple, you wonder how the commercial opportunities they offer weren’t spotted earlier. That’s basically the case with Olivia Humphrey and Kanopy, the DVD and online video streaming service that now caters for universities and colleges around the world. “I was surprised that despite students being the highest consumers of online video, online video was not used in the higher education curriculum at all,” Humphrey says. “So we set out to fill that gap.” Now her Subiaco-based business is the leading DVD and online video provider for the Australian tertiary sector. “There are 39 universities in Australia and we also work with the TAFE sector and we’ve also expanded into the AsiaPacific region,” Humphrey says. The company is also making inroads into the US and Kanopy counts Harvard Business School among its clients. “Kanopy now has more customers – colleges and universities – in the US than in the rest of the world combined,” Humphrey says. “But in the US there are about 4,500 universities and colleges so we’ve still got a long way to go, and our US office is opening in San Francisco in June.” Humphrey, the founder and managing director of Kanopy, won the Growth category of the 2012 WA Innovator of the Year Awards for its video streaming service. Think of it almost as a ‘Netflix for the education sector’ subscription service and you’ve just about got it, with Kanopy taking care of copyright clearances and being a one-stop service tying up all the admin details for librarians and administrators. Disruptive model It also keeps track of how many people view each title and even the number of minutes played. “I think one of the reasons we won the award is that the business model is quite innovative – we really disrupted the two industries, the media and entertainment industry in terms of getting all the filmmakers onboard, and the library vendor model as well,” she says. “Another reason is the sophisticated video platform that hosts and streams the videos to the end user. Our in-house IT team developed the platform which offers a suite of apps designed to increase user-engagement.” Kanopy has now grown to employ a dozen people, and expects that its US operations will eventually double this number. Its video collection is also fast growing. It has a library of some 15,000 videos – the largest of its kind in the world – and it utilises huge backup servers in the cloud. Humphrey says winning the IOTY award helped the fledgling company advance to the next level. “It’s really helped us grow,” she says. “We’ve had some significant investor interest since the awards and it’s also really helped with networking. Ideas, inspiration and innovation in WA Inspiring “We have a lot of contacts who have helped with understanding the landscape of government grants and assistance that can help Kanopy grow internationally. “It’s also been interesting and inspiring meeting the other applicants and previous winners and being involved in those networking functions. “But I think for me the two major things are that it was an excellent, excellent experience in terms of the presentations skills and workshops – which really helped me develop and refine my elevator pitch that has been used very extensively since! “The experience of presenting to a panel was fantastic and of course really helped with understanding the financing options for the development of our platform to facilitate our global growth. “That was probably the most helpful part. By the time I actually presented to the judges I felt so confident.” She says one of the other benefits was going through a process that enabled Kanopy to objectively review what it had achieved in its short life and have it assessed by experts in the innovation field. “Winning the award was great recognition from the industry that what we were achieving was not only important, but pretty amazing,” she says. “It was a very proud moment for all of us and very motivating for the team.” Online video was not used in the higher education curriculum at all. So we set out to fill that gap. < > The high-tech minnow that became a global mining services leader For Peter Clarke and the team at Scanalyse, the last few years since winning the 2007 WA Inventor of the Year Award have been a bit of a blur. It now has some 30 mining clients across Australia representing about 25 per cent of the market and another 20 clients internationally. It has customers in more than 20 countries, employs 36 people, and has a turnover of some $10 million. Because it only takes minutes to scan the inside of a mill, the device can help improve safety and save the global mining industry millions of dollars in downtime. To cap it off, the company is set to expand into many more countries after it was purchased in early 2013 by the large international Finnish mining technology company Outotec. Clarke says that while winning the IOTY award was rewarding, even entering the awards had its benefits as it helped the Scanalyse team sharpen up its act prior to going to market. Clarke says he was pleasantly surprised when Scanalyse won the IOTY award in 2007, mainly because it was still early days for the company. But the win helped catapult Scanalyse to a new level. “In preparing for the competition, you need to distil your value proposition, your message to clients and customers, so it helped us to refine that,” he says. “It certainly benefited us as a company immediately in the 12 months after winning the award by raising our profile,” he says. Invaluable “The process we went through with the various training and information sessions was invaluable.” And the lessons learnt are still handy. “It also contributed to us being able to successfully raise some investment funds of $1 million in 2008. “Once we had been selected as a finalist, we went through the entrepreneurship unit of the MBA course run at UWA,” Clarke says. “That really enabled us to finish off some of our product development and also helped us to start that international expansion as well.” “I personally found that extremely useful. I’m still using the lessons that I learnt through that process.” The company’s first product, MillMapper, was the result of a collaboration between Curtin University and the Cooperative Research Centre for Spatial Information (CRCSI). MillMapper is a 3-D laser scanner that can quickly and accurately measure wear in the metal linings of the giant mills used to grind ores in the precious metals industry. Ideas, inspiration and innovation in WA He says the awards process can be especially helpful for researchers and innovators who might be experts in their field but are relatively inexperienced in key areas such as business and marketing plans. “I strongly support the IOTY process because it delivers an enormous amount of value to all the participants through the training they get,” Clarke says. “It’s very difficult to get that training elsewhere in such a concentrated time.” “I think the whole program has enormous flow-on benefits throughout the scientific-research engineering community because the people who go into the program come out of it a lot better informed – and a lot more capable in those areas than they would have been before.” World-first Scanalyse has since gone on to develop a related product, CrusherMapper, which uses applies 3-D modelling to forecast wear rates of gyratory crushers. The company says its laser scanner can collect some 10 million data points in less than five minutes and, like MillMapper, is a world-first product. Clarke says the purchase of Scanalyse by Outotec will help the company expand further, quicker. “I’m looking forward to some new challenges,” he says. “We’ve got the technology right, we’ve got the value propositions and everything is right – it’s just now the big challenge for the company is the distribution network – and trying to develop your own is a costly exercise. “So now that we’re linked up to a company that has those distribution networks there’s a lot of expansion that’s going to be coming up.” People who go into the program come out of it a lot better informed – and a lot more capable in those areas than they would have been before. < > Developing innovative ear gear for rock miners – and even rock bands Justin Miller says he continues to be surprised at how Sensear’s innovative communication headsets are used around the world. “The uses and applications are enormous and it never ceases to amaze me where some of our headsets pop up and how they’re being used,” says Miller, the CEO of Sensear. “The main focus has been in mining, oil and gas industries. But they’re used in all sorts of different environments, from AC/DC rock concerts to working with aircraft in Antarctica. Even police in the US use them at NFL football games in San Diego.” The fledgling company was a finalist in the 2006 WA Inventor of the Year Awards for its revolutionary technology which utilises algorithms to suppress noise and enhance speech. The company has since developed a range of headsets that allows people to communicate more effectively in noisy workplaces. “We’ve built a big distribution base globally and ultimately sell to Fortune 500 companies around the world,” Miller says. “The Americas now represent most of our market – from Canada and North America right down to South America, with Brazil one of our bigger markets.” Sensear is based in Perth and has established its global sales and marketing headquarters in San Francisco. Earlier this year, the company announced it had developed an innovative wireless Bluetooth headset – the XBT – in partnership with the technology giant Motorola. Ideas, inspiration and innovation in WA Miller says the deal arose from a growing trend in the two-way radio market. “Our success was born off the back of the resources sector – mining, oil and gas,” he says. “Some 75% of people who buy our sets are patching them through a two-way radio,” he says. “We did all our prototyping with big miners out of Western Australia and we were able to leverage that. “At the same time, there’s this shift across the two-way industry from analogue to digital solutions. “That’s where we were born, but now we’re used in all facets of high-noise communications.” “As part of that change, Motorola have integrated Bluetooth and a lot of different things into their two-way radios. Miller says he believes Sensear is not the only R&D success to spin out of the resources sector. It also gives Sensear a foot in the door to a huge market. “I think there are a lot of companies in WA that have developed technology, like Sensear, that’s utlised in mining and is then used in other industries and other parts of the world to everyone’s benefit, really,” he says. “There are some 40 million plus two-way radios globally, of which two million have already been converted to digital,” he says. When Sensear entered the WA Inventor of the Year Awards, it was still in its infancy. “I don’t think we had made any sales at that point,” he recalls. “So it’s a massive opportunity for us, especially with Motorola having some 60-70% of that market share.” “We were after local recognition that was going to help us build credibility and awareness among the mining community – and it certainly did that for us.” “It created an opportunity for us to provide a solution to Motorola that they didn’t have.” The technology behind Sensear was developed by Professor Sven Nordholm, the company’s chief scientist. It was further developed at the Western Australian Telecommunications Research Institute (WATRI), a joint facility involving Curtin University of Technology and the University of WA. The company’s original focus was on servicing the resources sector. Miller says, in that respect, being located in WA gave Sensear a competitive edge. His advice to would-be innovators thinking of entering the awards? “Do it. I think it’s great that WA is promoting a cause such as this,” Miller says. “Globally, I think the awards would rank up there with some of the better funded awards. “To commercialise any invention, you need exposure and the IOTY is an ideal opportunity to help make that happen.” WE DID ALL OUR PROTOTYPING WITH BIG MINERS OUT OF WESTERN AUSTRALIA AND WE WERE ABLE TO LEVERAGE THAT. < > Targeting the faulty genes that can kill kids On the wall above his office desk, Professor Steve Wilton has pinned dozens of photos of boys afflicted with a cruel muscle-wasting disease that will eventually kill them. “I get these sent to me from the parents,” he says. “It’s easy to keep motivated when you’ve got this in your face all the time and you know these families are out there and they’re really desperate (for a treatment).” That motivation helped Wilton and colleague Professor Sue Fletcher come up an innovative treatment for Duchenne muscular dystrophy which won the overall WA Innovator of the Year Award in 2012. Duchenne muscular dystrophy is a genetic disorder that affects about one in 3,500 boys worldwide. The researchers have devised a way to bypass the defect in a faulty gene that is responsible for the disease. “It’s like molecular surgery, where we snip out the gangrenous part when the gene is being expressed,” Prof. Wilton says. “So in effect, we’re snipping out the mutations.” The results so far are encouraging. “From data released to date, the boys being treated have stabilised, and are not getting worse,” he says “If not treated, some of them probably would be in wheelchairs by now.” Prof. Wilton and his team recently signed a deal with the US drug company Sarepta Therapeutics to commercialise their research. Under the deal, the team will get up to US$7.1 million in upfront and milestone payments, as well as a royalty on net sales of all medicines developed and approved. Ideas, inspiration and innovation in WA The team is now looking at extending its work to help fight other diseases. Spotlight “If you know what the gene defect is – for say, asthma, stroke, Alzheimer’s or heart disease or multiple sclerosis – you have a gene target where we may be able to modify its expression. Depending on the specific problem, we have the potential to develop treatments for some of these conditions,” he says. Prof. Wilton says winning the IOTY award helped put his and Prof. Fletcher’s research in the spotlight. “I think we’ve got a lot more credibility, people are taking a lot more notice of us,” he says. “There’s some excellent research being done in Western Australia and around the world, but this lifts you a little above the pack and gives you gives you a bit of a leg up.” The pair has already extended their work to another disease, spinal muscular atrophy. “Most people haven’t heard of it but it’s the leading cause of death for children under the age of two,” Prof. Wilton says. “They don’t have enough of a particular gene product to keep their motor nerves alive. Their muscles are fine, but the nerves that control the muscles are dying. So the muscles don’t get a signal from the brain and they’re paralysed. Carriers “It’s a truly hideous disease and the carrier rate for this disease is one in 40. “If you consider a footy match at Subiaco with 40,000 people there, in the crowd there would be a thousand carriers of this disease.” Professors Wilton and Fletcher were carrying out their award-winning research at The University of WA. Since winning the IOTY, Prof. Wilton has been appointed Foundation Chair in Molecular Therapies at the Centre for Comparative Genomics and moved to Murdoch University. He will continue in an adjunct position at UWA and has also been appointed Director of Australian Neuromuscular Research Institute “The research will continue to expand, some of it will be at Murdoch and some carried out on the QE II campus,” he says. One of the first diseases in the team’s sights is multiple sclerosis, or MS. “The MS Society doesn’t even regard MS as a rare disease, the condition is so prevalent,” he says. “So far, we’ve been using a rare disease as proof of concept, and now we’re in the phase of expanding it to other conditions such as MS. We already have several targets in our sights and the research has started.” If you consider a footy match at Subiaco with 40,000 people there, in the crowd there would be a thousand carriers of this disease.