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The 33rd Annual Meeting of the Japanese Society for Bone and
The 33rd Annual Meeting of the Japanese Society for Bone and Mineral Research July 23―25, 2015 President: Naoyuki Takahashi (Matsumoto Dental University) Keio Plaza Hotel, Tokyo, Japan － 239 － The 33rd Annual Meeting of JSBMR 2015 Keio Plaza Hotel, Tokyo, Japan Thursday July 23 Thursday, Room Name 8:00 9:00 Opening Conference Room 1 Concord B 5F 10:00 11:00 12:00 13:00 14:00 15:00 16:00 Invited Invited Lecture 2 Lecture 3 14:10-15:10 15:10-16:10 17:00 JSBMR & The Japan Endocrinology Society Joint Symposium 8:30-10:30 Symposium 1 10:30-12:00 Luncheon Seminar 1 12:10-13:10 Invited Lecture 1 9:30-10:30 JSBMR Committee Symposium 1 Luncheon Seminar 2 Oral 3 Oral 4 Symposium 3 Oral Poster Luncheon Seminar 3 Oral 5 Oral 6 JSBMR Committee Symposium 2 Conference Room 2 Concord C 5F Oral１ 8:30-9:30 Conference Room 3 Concord A 5F Oral 2 Conference Room 4 Kaede 4F Meet the Experts 1 13:10 14:10 13:10-14:10 Conference Room 5 Katsura 4F Meet the Experts 2 Conference Room 6 Natsume 4F Meet the Experts 3 Exhibition Hall Hana 4F Poster Set-Up 8:00-11:00 Poster Presentation Poster Open 11:00-13:10 Symposium 2 16:10-17:40 18:00 19:00 20:00 Evening Seminar 1 17:50-19:40 Evening Seminar 2 17:50-19:20 Poster Open 14:10-18:00 Exhibition 8:30-18:00 Friday, July 24 8:00 9:00 10:00 11:00 12:00 JSBMR ＆ The Japanese JSBMR Committee Orthopaedic Association Symposium 3 Joint Symposium 8:30-10:30 10:30-12:00 Conference Room 1 Concord B 5F Conference Room 2 Concord C 5F Invited Lecture 4 8:30-9:30 Conference Room 3 Concord A 5F Oral 7 Exhibition Hall Hana 4F Invited Lecture 5 9:30-10:30 13:00 Luncheon Seminar 4 12:10-13:10 Symposium 4 Luncheon Seminar 5 JSBMR Committee Symposium 4 Luncheon Seminar 6 14:00 15:00 16:00 JSBMR General Meeting Invited Award Lectures Lecture 7 13:20-15:20 15:20-16:20 Invited Lecture 6 Oral 8 14:20-15:20 17:00 Symposium 5 16:20-17:50 Evening Seminar 3 Oral 10 Evening Seminar 4 Oral 9 Poster Open 8:30-18:00 Saturday, July 25 Concord B 5F Conference Room 2 Concord C 5F 8:00 Morning Session 7:30-8:30 Morning Seminar 9:00 10:00 11:00 12:00 JSBMR & Japan College JSBMR Committee of Rheumatology Clinical Symposium Joint Symposium 8:30-10:30 10:30-12:00 Oral 11 8:30-10:00 JSBMR & KSBMR, KSO Joint Symposium 13:00 14:00 Luncheon Seminar 7 12:10-13:10 15:00 16:00 JSBMR Committee Oral 15 Symposium 5 14:10-15:10 15:10-16:30 Luncheon Seminar 8 Oral 16 Symposium 6 Basic Clinical 10:00-11:00 11:00-12:00 Conference Room 3 Concord A 5F O l 12 Oral O l 13 Oral O Orall 14 Luncheon Seminar 9 S Symposium i 7 Conference Room 4 Kaede 4F Meet the Experts 4 13:10-14:10 Conference Room 5 Katsura 4F Meet the Experts 5 Conference Room 6 Natsume 4F Meet the Experts 6 Poster Open 8:00-13:10 Exhibition Hall Hana 4F Poster Presentation Exhibition 8:00-13:00 － 241 － Poster Poster Open Removal 14:10-15:00 15:00-16:00 Closing Conference Room 1 19:00 Evening Session 18:00-19:30 Women Researchers’ Session Exhibition 8:30-18:00 Room Name 18:00 19:40 ~ JSBMR Reception Party Room: Eminence 5F Room Name Invited Lecture 1 Chair: Sakae Tanaka My research on "vitamin D and bone" grown up with the Japanese Society for Bone and Mineral Research Tatsuo Suda Research Center for Genomic Medicine, Saitama Medical University Invited Lecture 2 Chair: Yoshiya Tanaka Diabetes mellitus and bone metabolism Toshitsugu Sugimoto Internal Medicine 1 Shimane Universary Faculty of Medicine Invited Lecture 3 Chair: Toshio Kukita Targeting p62（sequestosome 1）to Block Osteoblast Suppression in Multiple Myeloma G.David Roodman 1, Jumpei Teramachi 1, Rebecca Silbermann 1, Peng Yang 2, Wei Zhao 1, Khalid Mohammad 1, Rentian Feng 2, Jan H Beumer 6, Julie L Eiseman 4, Jolene Windle 3, Xiang-Qun Xie 2, Noriyoshi Kurihara 1 Department of Medicine, Indiana University, USA 1, Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, University of Pittsburgh, USA 2, Department of Human and Molecular Genetics, Virginia Commonwealth University, USA 3, Department of Pharmacology Chemical Biology, University of Pittsburgh, USA 4, Department of Radiology, Indiana University, USA 5, Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh, USA 6 Invited Lecture 4 Chair: Seiji Fukumoto INTERCELLULAR COMMUNICATION IN REMODELING: DEVELOPMENT OF CONCEPTS AND THEIR APPLICATION T. John Martin Department of Hematology, Baltimore Memorial Hospital, USA/ St.Vincent's Institute of Medical Research, University of Melbourne, Australia Invited Lecture 5 Chair: Hidehiro Ozawa Autophagy Noboru Mizushima The University of Tokyo Invited Lecture 6 Chair: Naoto Endo OSTEOPOROSIS TREATMENT 2015 Henry G. Bone Michigan Bone & Mineral Clinic, USA Invited Lecture 7 Chair: Keiichi Ozono Genetics of Parathyroid Disorders Rajesh V. Thakker Nuffield Department of Medicine, University of Oxford, OCDEM, Churchill Hospital, UK － 242 － JSBMR & KSBMR, KSO Joint Symposium（Basic） Chairs: Yoon-Sok CHUNG Toshihisa Komori OSTERIX REGULATION IN SKELETON : FROM BONE TO ANOTHER Jung-Eun Kim Cell and Matrix Research Institute, Department of Molecular Medicine, Kyungpook National University School of Medicine, Korea Inhibitory effects of Trolox on osteolytic bone metastasis Zang Hee Lee Department of Cell and Developmental Biology, School of Dentistry, Seoul National University, Korea New players in skeletal system and their unexpected roles: novel molecules for novel therapies Kenta Maruyama Immunology Frontier Research Center, Osaka University, Japan JSBMR & KSBMR, KSO Joint Symposium（Clinical） Chairs: Kyu Hyun Yang Akinori Sakai Etiology and pathogenesis of FGF23-related hypophosphatemia Yuka Kinoshita 1, Seiji Fukumoto 2 Division of Nephrology and Endocrinology, The University of Tokyo Hospital 1, Fujii Memorial Institute of Medical Sciences, The University of Tokushima, Japan 2 INCREASED BODY WEIGHT AND SARCOPENIC OBESITY: CAUSES OF INTERTROCHANTERIC FRACTURE IN NON-OSTEOPOROTIC FEMALE PATIENTS Hyung-Min JI Department of Orthopedic Surgery, Ajou University Hospital, Korea Bone Metabolism in Lumbar Spinal Stenosis Seong-Hwan Moon Department of Orthopaedic Surgery, Yonsei University College of Medicine, Korea JSBMR and The Japan Endocrine Society Joint Symposium Osteoporosis induced by abnormality of hormone actions Chairs: Keiichi Ozono Seiji Fukumoto Clinical issues on primary hyperparathyroidism focusing on osteoporosis Yasuhiro Takeuchi Toranomon Hospital Endocrine Center Bone metabolism in diabetes mellitus Ippei Kanazawa Internal Medicine 1, Shimane University Faculty of Medicine Treatment for glucocorticoid induced osteoporosis Yosuke Okada, Yoshiya Tanaka First Departmental of Internal Medicine, University of Occupational and Environmental Health Male hypogonadism and osteoporosis Sumito Ogawa Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo － 243 － Osteoporosis due to primary hypogonadism -Lessons from the pathophysiology of Turner syndromeNoriyuki Namba Department of Pediatrics, JCHO Osaka Hospital Osteoporosis associated with aromatase inhibitor therapy for breast cancer Shunji Takahashi Department of Medical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research JSBMR and The Japanese Orthopaedic Association Joint Symposium Orthopedics and bone/cartilage metabolism Chairs: Eiji Itoi Hideki Yoshikawa An Overview of Locomotive Diseases and Their Relationship to Bone and Cartilage Research Eiji Itoi Department of Orthopaedic Surgery, Tohoku University School of Medicine Therapeutic approach for osteoporosis and joint destruction in rheumatoid arthritis Sakae Tanaka Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo Cell reprogramming technologies and cartilage disorders Noriyuki Tsumaki Center for iPS Cell Research and Application, Kyoto University Clinical condition and treatment strategy of osteoporotic spinal lesions Naohisa Miyakoshi Department of Orthopedic Surgery, Akita University Graduate School of Medicine Ossification of the posterior longitudinal ligament（OPLL）is caused by bone and mineral metabolism disorder? -A possible interaction between OPLL and bone metabolismMorio Matsumoto 1, Takeshi Miyamoto 1, Keisuke Horiuchi 1, Takashi Tsuji 2, Shiro Ikegawa 3 Dept. of Orthopaedic Surgery, Keio University 1, Dept. of Orthopaedic Surgery, Kitasato Institute Hospital 2, Laboratory of Bone and Joint Diseases, Center for Integrative Medical Sciences, RIKEN, 3 Prevention and treatment of fractures by regulating bone metabolism Akinori Sakai Department of Orthopaedic Surgery, University of Occupational and Environmental Health Relations between Bone Tumor and Bone Metabolism Hideki Yoshikawa Department of Orthopaedic Surgery, Osaka University JSBMR and Japan College of Rheumatology Joint Symposium Inflammation and bone Chairs: Hiroshi Takayanagi Satoshi Soen Intravital bone imaging dissecting the‘real’mode of actions of osteoclastic bone destruction Masaru Ishii Osaka University Graduate School of Medicine and Frontier Biosciences Bone fragility and erosion by inflammation Takeshi Miyamoto, Morio Matsumoto, Masaya Nakamura Keio University School of Medicine － 244 － Treatment of bone damage in inflammatory joint diseases Yoshiya Tanaka The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan Can we reduce fractures and prevent bone loss in Japanese patients with rheumatoid arthritis? Takefumi Furuya, Hisashi Yamanaka Institute of Rheumatology, Tokyo Women's Medical University Symposium 1 Big data analysis Chairs: Shiro Ikegawa Yuuki Imai The era of big data analysis Shiro Ikegawa Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences Identification of transcription factors contributing cell differentiation by big data analyses Yuuki Imai 1 Division of Integrative Pathophysiology, Proteo-Science Center, Graduate School of Medicine, Ehime University 1, Division of Laboratory Animal Research, Advanced Research Support Center, Ehime University 2 Statistical Genetics in the Big Data era and its contribution to disease biology and novel drug discovery. Yukinori Okada Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University Large scale data sets in genomics driving life sciences Hideya Kawaji RIKEN Symposium 2 Discovery of new proteins in Japan Chairs: Akira Kudo Hisataka Yasuda Periostin Akira Kudo Tokyo Institute of Technology Discovery of OPG and RANKL Hisataka Yasuda Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd. Discovery of FGF23-Klotho system as a new mechanism regulating phosphate/vitamin D metabolism Takeyoshi Yamashita 1, Seiji Fukumoto 2 Kyowa Hakko Kirin Co., Ltd. 1, Fujii Memorial Institute of Medical Sciences, Tokushima Univ. 2 Molecular cloning of genes predominantly expressed in bone cells. Ken-ichi Tezuka Gifu University Graduate School of Medicine － 245 － Milk Basic Protein, MBP, inhibits bone resorption and stimulates bone formation simultaneously Akira Itabashi Saitama Center for Bone Research（SCBR）,Kubojima Clinic Symposium 3 Basic and clinical advances in bone and cartilage diseases Chairs: Noriyuki Tsumaki Chisa Shukunami Regulation of vertebral column development by Pax1 and Sox9 Aki Takimoto 1, Yuji Hiraki 1, Chisa Shukunami 1,2 Department of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University 1, Department of Molecular Biology and Biochemistry, Institute of Biomedical & Health Sciences 2 Mechanical stimulation regulates cartilage metabolism via extracellular ATP and PGE2 signaling Hiroyasu Ogawa Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine Regulation of Osteoarthritis by Notch/Rbpj/Hes1 Pathways Taku Saito Bone & Cartilage Regenerative Medicine, University of Tokyo Hospital Development and applications of protocols for differentiating pluripotent stem cells into osteoblasts in a stepwise manner Shinsuke Ohba Department of Bioengineering, The University of Tokyo Graduate School of Engineering Symposium 4 Regeneration of tooth and periodontal tissues Chairs: Hidetoshi Yamazaki Naoto Suda Overview –Specificity of teeth as hard tissueNaoto Suda Meikai University School of Dentistry Characteristics and derivation of murine dental mesenchymal cells Hidetoshi Yamazaki Institute of Medical Science, Mie University Graduate School of Medicine Organ Regeneration as a Next-generation of Regenerative Medicine Takashi Tsuji 1,2 RIKEN 1, Organ Technologies Inc. 2 Mechanisms in determining tooth number Atsushi Ohazama Division of Oral Anatomy, Niigata University Clinical Trial of Regenerative Pulp Therapy using Autologous Dental Pulp Stem Cells for Longevity of Teeth Misako Nakashima, Koichiro Iohara, Masashi Murakami, Yohei Osako National Center for Geriatrics and Gerontology, Research Institute Periodontal regeneration with autologous periodontal ligament cell sheets. Takanori Iwata 1,2 Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University 1, Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University 2 － 246 － Symposium 5 Bone and bone marrow microenvironments Chairs: Takeshi Miyamoto Tomoki Nakashima Vascular niches for hematopoietic stem cells Yuya Kunisaki Kyushu University Center for Cellular and Molecular Medicine Foxc1 is a critical regulator of hematopoietic stem/progenitor cell niche formation and maintenance. Yoshiki Omatsu Institute for Frontier Medical Sciences, Kyoto University Developmental origin of bone marrow mesenchymal stem cells Toshihide Mizoguchi Institute for Oral Science, Matsumoto Dental University Bone-pinnacled inter-organ communication: clinical application of its transient deviation and hematologic disorders by its irreversible desruption Yoshio Katayama Hematology, Kobe University Hospital Symposium 6 Coupling between bone resorption and formation Chairs: Koichi Matsuo Nobuyuki Udagawa Does coupling between bone resorption and formation occur during membranous and endochondral ossification? Koichi Matsuo Keio University School of Medicine Osteoclast-derived coupling factors Sunao Takeshita Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology Osteoblast differentiation via RANKL Yuriko Furuya, Hisataka Yasuda Oriental Yeast Co.,Ltd. Nagahama Research Institute Role of RANKL reverse signaling in osteoblastic cells Masashi Honma 1, Madoka Hayashi 1, Yuki Ikebuchi 1, Shigeki Aoki 1, Yasutaka Sugamori 2, Kazuhiro Aoki 2, Hiroshi Suzuki 1 Department of Pharmacy, The University of Tokyo Hospital 1, Department of Bio-Matrix/Pharmacology, Tokyo Medical and Dental University 2 Important role of osteoprotegerin in bone remodeling Nobuyuki Udagawa Department of Biochemistry, Matsumoto Dental University Symposium 7 Disorders in mineral and bone metabolism Chairs: Yasuhiro Takeuchi Masafumi Fukagawa Physiological and pharmacological actions of parathyroid hormone Hiroshi Kaji Department of Physiology and Regenerative Medicine, Kinki University Faculty of Medicine － 247 － Insights into the physiological function of vitamin D Ritsuko Masuyama Nagasaki University Graduate School of Biomedical Sciences FGF23 in Disorders of Bone and Mineral Metabolism Toshimi Michigami Department of Bone and Mineral Research, Osaka Medical Center and Research Institute for Maternal and Child Health Treatment Strategy for CKD-MBD Based on its Pathophysiological Mechanism Junichiro Kazama Division of Blood Purification Therapy, Niigata University Medical and Dental Hospital JSBMR Committee Clinical Symposium Vitamin D insufficiency and deficiency Update Chairs: Toshitsugu Sugimoto Seiji Fukumoto Vitamin D deficiency and insufficiency in children: Problems in its diagnosis and treatment Hiroyuki Tanaka Department of Pediatrics, Okayama saiseikai General Hospital Fragility fractures and vitamin D Hiroshi Hagino Tottori University Proposal for the Japanese guideline of vitamin D deficiency/insufficiency Ryo Okazaki Third Department of Medicine Teikyo University Chiba Medical Center JSBMR Committee Symposium 1 Industry-academia collaboration Chairs: Yoshiomi Morishita Sakae Tanaka Commercialization of Biotechnology and Open-innovation Yoshiaki Tsukamoto Japan Bioindustry Association University-industry collaborations in Japan Takafumi Yamamoto TODAI TLO, Ltd. New paradigm of drug discovery and development in Japan; Japan Agency for Medical Research and Development（AMED）accelerates drug discovery by bridging between academia and industry sectors Kenji Arima Center for Innovative Drug Discovery and Development, Japan Agency for Meical Research and Development JSBMR Committee Symposium 2 Inter-organ and inter-cell communication（by young members of physicians） Chairs: Shu Takeda Toshimi Michigami Progress in the management of skeletal dysplasias Takuo Kubota Department of Pediatrics, Osaka University Graduate School of Medicine － 248 － Lifestyle-related diseases and bone Mika Yamauchi Internal Medicine 1, Shimane University Faculty of Medicine TGF-beta has maintained the bone remodeling to induce the coupling factor which has regulated to crosstalk between osteoclast and osteoblast Kuniaki Ota 1, Sundeep Khosla 2, Merry Jo Oursler 2 Nasu Red Cross Hospital, Department of Obstetrics and Gynecology 1, Mayo Clinic, Endocrine Research Unit 2 Arthritis treatment and bone/cartilage repair by mesenchymal stem cells Kaoru Yamagata 1, Shingo Nakayamada 1, Kazuhisa Nakano 1, Koshiro Sonomoto 1, Masahiro Kondo 2, Koichi Oshita 2, Xiangmei Zhang 1, Hiroaki Kaneko 3, Makoto Satake 3, Yuka Yamamoto 3, Kunihiro Yamaoka 1, Yoshiya Tanaka 1 The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan 1, Mitsubishi Tanabe Pharma Corporation 2, TEIJIN 3 JSBMR Committee Symposium 3 Topics in bone metabolism（by young members of surgeons） Chairs: Noriyuki Tsumaki Takayoshi Nakano Takeshi Miyamoto Application of patient-derived iPS cells for Fibrodysplasia Ossificans Progressiva（FOP）research Kyosuke Hino 1,2, Yoshihisa Matsumoto 1,3,4, Makoto Ikeya 1, Kazuhiko Horigome 1,2, Sanae Nagata 1, Junya Toguchida 1,4,5 Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application（CiRA） 1, iPS Cell-Based Drug Discovery Group, Innovative Drug Discovery Laboratories, Sumitomo Dainippon Pharma Co., Ltd. 2, Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoy 3, Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University 4, Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University 5 Bone Functional Adaptation by Remodeling: Mathematical Modeling and Simulation Taiji Adachi Institute for Frontier Medical Sciences, Kyoto University Preferential orientation of biological apatite dominates mechanical function of bone Takuya Ishimoto, Takayoshi Nakano Graduate School of Engineering, Osaka University JSBMR Committee Symposium 4 Basic: Rising stars in bone biology（by young members of basic scientists） Chairs: Masaru Ishii Yuuki Imai Using iPS cell disease model to study FGFR3 skeletal dysplasia Akihiro Yamashita, Noriyuki Tsumaki Kyoto University Centre for iPS Cell Research and Application Role of metabolic-epigenetic coupling in osteoclast differentiation Keizo Nishikawa Laboratory of Immunology and Cell Biology, WPI-Immunology Frontier Research Center, Osaka University － 249 － Synergistic activity of a novel Th17 cell subset with synovial fibroblasts in inflammatory bone destruction Noriko Komatsu 1, Lynett Danks 1, Tomoki Nakashima 2, Hiroshi Takayanagi 1,3 Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo 1, Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University 2, JST ERATO Takayanagi Osteonetwork Project 3 JSBMR Committee Symposium 5 Frontier of muscle, tendon and ligament research Chairs: Hiroshi Asahara Chisa Shukunami Activation of calcium signaling as a key trigger of skeletal muscle hypertrophy Naoki Ito 1,2, Noriaki Shimizu 2, Hirotoshi Tanaka 2, Shin'ichi Takeda 1 National Institute of Neuroscience, National Center of Neurology and Psychiatry 1, Department of Rheumatology and Allergy, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo 2 Glucocorticoid response in skeletal muscle is involved in the regulatory network for energy metabolism Noriaki Shimizu 1, Hirotoshi Tanaka 1,2 Department of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, University of Tokyo 1, Division of Rheumatology, Center for Antibody and Vaccine, IMSUT Hospital, Institute of Medical Science, University of Tokyo 2 Scleraxis is required for the formation of fibrocartilaginous enthesis Yuki Yoshimoto 1, Aki Takimoto 2, Yuji Hiraki 2, Chisa Shukunami 1 Department of Dental and Medical Biochemistry, Basic Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan 1, Institute for Frontier Medical Sciences, Cellular Differentiation, Kyoto University, Kyoto, Japan 2 Transcription factor Mohawk homeobox gene is essential in development and regeneration of outer annulus fibrosus of intervertebral discs Ryo Nakamichi, Hiroshi Asahara SystemsBiomedicine, Tokyo Medical and Dental University Women researchers’Session Work-life balance and carrier formation Chairs: Yoshiki Seino Masako Ito Good Work and Life Career for Women Researchers Masako Ito Center for Gender Equality, Nagasaki University Reconciling of family life and career Yuko Sakamoto Juntendo Univ. Nerima Hosp. As a woman aiming to become a researcher Ritsuko Masuyama Nagasaki University Graduate School of Biomedical Sciences － 250 － Meet the Experts 1 Osteoporosis associated with COPD（chronic obstructive pulmonary disease）and other lifestylerelated diseases. Ryo Okazaki Third Department of Medicine Teikyo University Chiba Medical Center Meet the Experts 2 The dynamic function of ion transport in living osteoclasts Koji Okabe Department of Physiological Science and Molecular Biology, Fukuoka Dental College Meet the Experts 3 History and forefront of CCN family research Masaharu Takigawa ARCOCS, Okayama University Dental School Meet the Experts 4 The present and future of osteoarthritis treatment Hiroshi Kawaguchi Japan Community Health Care Organization（JCHO）,Tokyo Shinjuku Medical Center Meet the Experts 5 The Pathogenesis of Paget's Bone Disease Noriyoshi Kurihara Division of Hematology/Oncology, School of Medicine, Indiana University Meet the Experts 6 Molecular mechanisms of physiological and pathological bone formation Takenobu Katagiri Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University Morning Session Bone and health Chairs: Takayuki Hosoi Keizo Sakamoto Vitamin D ―Role of Vitamin D as a hormone for healthy ageing― Hajime Orimo Kenkoin Medical Corporation Foundation The concept of locomotive syndrome and its clinical judgement values Kozo Nakamura National Rehabilitation Center for Persons with Disabilities Morning Seminar Imaging and diagnosis Chair: Teruki Sone Trabecular Bone Score: Clinical utility and limitation Masayuki Iki Department of Public Health, Kinki University Faculty of Medicine － 251 － HR-pQCT Opening Up the New World of Image Analysis Ko Chiba Department of Orthopedic Surgery, Nagasaki University School of Medicine Luncheon Seminar 1 Chair: Atsushi Suzuki The relationship between phosphate metabolism and vascular calcification as one of the chronic kidney disease related mineral and bone disorder（CKD-MBD） Takashi Shigematsu Department of Internal Medicine, Division of Nephrology, Wakayama Medical University Luncheon Seminar 2 Chair: Hiroshi Hagino Strategies for prevention of fractures in the super-aged society Yasuhiro Takeuchi Endocrine Center, Toranomon Hospital Luncheon Seminar 3 Chair: Masataka Shiraki Active Vitamin D and Osteoporosis Treatment Toshio Matsumoto Fujii Memorial Institute of Medical Sciences, University of Tokushima Luncheon Seminar 4 Chair: Toshio Matsumoto Mechanism of action and clinical efficacy of aminobisphosphoante Sakae Tanaka Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo Luncheon Seminar 5 Chair: Masaru Ishii Stop at One - Strategies for second fractures prevention Hiroshi Hagino School of Health Science, Tottori University Faculty of Medicine Luncheon Seminar 6 Chair: Yasuhiro Takeuchi Selection of anti-osteoporotic medication based on pathogenesis of osteoporosis Jun Iwamoto Institute for Integrated Sports Medicine, Keio University School of Medicine Luncheon Seminar 7 Chair: Masaki Noda A new aspect for osteoporosis treatment － network between bone and the other organs － Shu Takeda Dept. of Physiology and Cell Biology, Graduate School, Tokyo Medical and Dental University － 252 － Luncheon Seminar 8 Chair: Takeshi Imamura In vivo mode of therapeutic actions of several drugs targeting bone diseases revealed by intravital imaging technique Masaru Ishii Department of Immunology and Cell Biology, Osaka University Graduate School of Medicine Luncheon Seminar 9 Chair: Hiroaki Ohta Anti-osteoporosis drugs and the changes of bone turnover markers. Effect of MBP（Milk Basic Protein）as an example. Akira Itabashi Saitama Center for Bone Research（SCBR） Evening Session Osteonecrosis of the jaw – Dentistry and medical cooperation Chairs: Masataka Shiraki Akira Taguchi Perceptions and Precautions Regarding Osteonecrosis of the Jaw in Osteoporosis Patients Henry G. Bone Michigan Bone & Mineral Clinic, USA Impact of oral hygiene in the treatment of osteoporosis Masataka Shiraki 1, Kazuhiro Uenishi 2, Akira Taguchi 3 Department of Internal Medicine、Research Institute and Practice for Involutional Diseases 1, Department of Nutritional Physiology, Kagawa University 2, Department of Oral and Maxillofacial Radiology, School of Dentistry, Matsumoto Dental University 3 Cooperation between medical professionals and dentists for preventing osteonecrosis of the jaws among osteoporosis patients Akira Taguchi 1, Sugino Noriyuki 1, Uchida Keiichi 1, Nakamoto Takashi 2 Department of Oral and Maxillofacial Radiology, School of Dentistry, Matsumoto Dental University 1, Department of Oral and Maxillofacial Radiology, Matsumoto Dental University 2 Evening Seminar 1 The 12th Bisphosphonate Update Evening Seminar 2 Treatment of osteoporosis, up-to-date Chair: Naoto Endo Chronic kidney disease and metabolic bone disease － Pathophysiology & treatment － Seiji Fukumoto Fujii Memorial Institute of Medical Sciences Recent progress in treatments of osteoporosis Yoshiya Tanaka The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health － 253 － Evening Seminar 3 Guidelines for primary and steroid-induced osteoporosis update- bisphosphonates- Chairs: Toshitaka Nakamura Toshitsugu Sugimoto Management and Treatment of Primary Osteoporosis from the 2015 Guidelines for Prevention and Treatment of Osteoporosis Hiroaki Ohta Department of Clinical Medical Research Center, International University of Health and Welfare / Women's Medical Center of Sanno Medical Center Management and Treatment of Glucocorticoid-induced Osteoporosis from 2014 revised guideline in JSBMR Yoshiya Tanaka The First Department of Internal Medicine, School of Medicine, University of Occupational & Environmental Health Evening Seminar 4 AGE: Bone and lifestyle-related diseases Chair: Sakae Tanaka Roles of SERMs on bone quality Mitsuru Saito Department of Orthopaedic Surgery, Jikei University School of Medicine AGE: A therapeutic target for anti-aging medicine Sho-ichi Yamagishi Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine － 254 － Oral Presentation O-001 Smad4 in osteoclasts reduce bone mass by inhibiting osteoclast differentiation ○ Mayu Morita 1, Ryotaro Iwasaki 1, Hiromasa Kawana 1, Taneaki Nakagawa 1, Takeshi Miyamoto 2 (Division of Oral Surgery, Department of Dentistry and Oral Surgery, Keio University School of Medicine 1, Department of Orthopedic Surgery, Keio University School of Medicine 2) O-002 Novel role of Nedd4 adaptor protein, Pmepa1 in the differentiation and function of osteoclasts ○ Xianghe Xu 1,3, Noboru Funakubo 1,3, Makoto Shiraki 1,2, Toshio Kukita 3, Akiko Kukita 1 (Department of Microbiology, Faculty of Medicine, Saga University 1, Department of Orthopaedic Surgery, Faculty of Medicine, Saga University 2, Deparment of Molecular Cell Biology & Oral Anatomy, Kyushu University 3) O-003 PKN3 regulates bone-resorbing activity of osteoclasts downstream of Wnt5a-Ror2 signaling ○ Shunsuke Uehara 1, Teruhito Yamashita 2, Takashi Nakamura 3, Shigeaki Kato 4, Nobuyuki Udagawa 1, Naoyuki Takahashi 2, Yasuhiro Kobayashi 2 (Department of Biochemistry, Matsumoto Dental University 1, Institute for Oral Science, Matsumoto Dental University 2, Department of Biochemistry and Integrative Medical Biology, School of Medicine, Keio University 3, Soma Central Hospital 4) O-004 The whole body-bone resorption system in OPG/RANKL double knockout medaka ○ Masahiro Chatani 1, Yoshiro Takano 2, Takeshi Todo 3, Akira Kudo 1 (Tokyo Institute of Technology 1, Tokyo Medical and Dental University 2, Osaka University 3) O-005 Identification and analysis of function of a novel splicing variant of receptor activator of NF-κB ○ Riko Kitazawa 1,2, Ryuma Haraguchi 2, Yosuke Mizuno 1, Yasuhiro Kobayashi 3, Sohei Kitazawa 2 (Department of Diagnostic Pathology, Ehime University Hospital 1, Department of Molecular Pathology, Ehime University Graduate School of Medicine 2, Institute of Oral Science, Matsumoto Dental University 3) O-006 Involvement of RANKL-induced incomplete cytokinesis in polyploidization of osteoclasts ○ Noriko Takegahara (IFReC, Osaka Univeristy) O-007 Mechanical strain induces cartilage degradation via P2X7-Reactive Oxygen Species-MMP13 axis ○ Hiroyasu Ogawa 1, Lassar Andrew 2, Kazu Matsumoto 1, Haruhiko Akiyama 1 (Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine 1, Harvard Medical School 2) O-008 Overexpression of CCN3 in cartilage induces delayed endochondral ossification and degenerative changes in articular cartilage ○ Takako Hattori 1, Koichi Kadoya 2, Miho Kuwahara 2, Mitsuaki Ono 3, Mitsuhiro Hoshijima 1,4, Takuo Kuboki 3, Satoshi Kubota 1,4, Masaharu Takigawa 1,4 (Department of Biochemistry & Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 1, Okayama University Dental School 2, Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 3, Okayama University Dental School, Advanced Research Center for Oral and Craniofacial Sciences4) O-009 Effect of quadriceps muscle strength on knee pain -The ROAD study○ Shigeyuki Muraki 1, Toru Akune 2, Hiroyuki Oka 3, Sakae Tanaka 4, Hiroshi Kawaguchi 5, Kozo Nakamura 2, Noriko Yoshimura 6 (Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, the University of Tokyo 1, National Rehabilitation Center for Persons with Disabilities 2, Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical & Research Center, Faculty of Medicine, the University of Tokyo 3, Department of Orthopaedic Surgery, Faculty of Medicine, the University of Tokyo 4, Japan Community Health care Organization Tokyo Shinjuku Medical Center 5, Department of Joint Disease Research, 22nd Century Medical & Research Center, Faculty of Medicine, the University of Tokyo 6) O-010 Withdrawn O-011 Human dendritic cell-derived osteoclasts possess the capacity of potent bone absorption and antigen presentation in the rheumatoid synovial tissue ○ Manabu Narisawa 1, Satoshi Kubo 1, Shingo Nakayamada 1, Jidong Zhao 1, Kei Sakata 2, Yosuke Okada 1, Kunihiro Yamaoka 3, Yoshiya Tanaka 1 (First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health1, Mitsubishi Tanabe Pharma Corporation 2, Division of Rheumatology Department of Internal Medicine Keio University School of Medicine 3) O-012 Rheumatoid arthritis induced deterioration of bone quality and bone fragility in periartcular cortical bone from early phase ○ Tomohiro Shimizu 1, Masahiko Takahata 1, Yusuke Kameda 1, Kaori Endo 1,3, Hiroki Hamano 1, Shigeto Hiratsuka 1, Masahiro Ota 1, Teppei Ito 2, Hiromi Kimura-Suda 2, Masahiro Todoh 3, Shigeru Tadano 3, Norimasa Iwasaki 1 (Department of Orthopaedic Surgery Hokkaido University Graduate School of Medicine 1, Department of Bio- and Material Photonics, Chitose Institute of Science and Technology 2, Division of Human Mechanical Systems and Design, Faculty of Engineering, Hokkaido University 3) － 255 － O-013 In Vivo Molecular Evidence and Mechanism of Tensile Force-Induced Vascularization During Early Mechanobiological Response of Cranial Sutures ○ Nobuo Takeshita, Kiyo Sasaki, Daisuke Seki, Shunro Miyashita, Ikuko Takano, Toshihito Oyanagi, Masakazu Hasegawa, Teruko Takano-Yamamoto (Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Health and Development, Tohoku University Graduate School of Dentistry) O-014 Effect of mechanical loading on osteocytic lacuna-canalicli network and alignment of biological apatite crystallites in rabbit ○ Muneteru Sasaki 1, Shinichiro Kuroshima 1, Takayoshi Nakano 2, Takashi Sawase 1 (Department of Applied Prosthodontics, Unit of Translationall Medicine, Graduate School of Biomedical Sciences, Nagasaki University 1, Biomaterials & Structural Materials Design Area Course of Materials Science & Engineering Division of Materials & Manufacturing Science Graduate School of Engineering, Osaka University 2) O-015 Identification of early response genes against microgravity ○ Masahiro Chatani 1, Akiko Mantoku 1, Kazuhiro Takeyama 1, Hiroya Morimoto 1, Takehiko Ito 1, Naoki Tanigawa 2, Kouji Kubota 2, Hiromi Suzuki 3, Satoko Uchida 3, Fumiaki Tanigaki 4, Masaki Shirakawa 4, Yoshiro Takano 5, Akira Kudo 1 (Tokyo Institute of Technology 1, CHIYODA Corporation 2, Japan Space Forum 3, Japan Aerospace eXploration Agency 4, Tokyo Medical and Dental University 5) O-016 Three-dimensional mechanical loading shows action similar to BMP and promotes endochondral ossfication and endosteal bone formation ○ Satoshi Miyamoto 1, Ken Nakata 2, Hideki Yoshikawa 1 (Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine 1, Department of Health and Sport Sciences, Osaka University Graduate School of Medicine 2) O-017 Elcatonin prevents bone loss due to skeletal unloading by suppressing bone resorption with unloading-induced high expression of calcitonin receptors in bone marrow cells ○ Manabu Tsukamoto, Kunitaka Menuki, Teppei Murai, Akihisa Hatakeyama, Shinichiro Takada, Kayoko Furukawa, Akinori Sakai (University of Occupational and Environmental Health) O-018 Analyses of an in vitro reconstitution system for the bone-related cell network by two photon microscopy ○ Atsuhiko Hikita 1, Tadahiro Iimura 2, Yusuke Oshima 2, Takeshi Imamura 2 (Department of Cartilage & Bone Regeneration（Fujisoft）Graduate School of Medicine, The University of Tokyo 1, Ehime University 2) O-019 Urokinase-type plasminogen activator is involved in macrophage accumulation through CCL3 during early stage of bone repair ○ Naoyuki Kawao 1, Yukinori Tamura 1, Yoshitaka Horiuchi 2, Katsumi Okumoto 2, Masato Yano 1, Kiyotaka Okada 1, Osamu Matsuo 1, Hiroshi Kaji 1 (Department of Physiology and Regenerative Medicine, Kinki University Faculty of Medicine 1, Life Science Research Institute, Kinki University 2) O-020 Among glucocorticoids, fluocinolone acetonide is unique in potentiating TGF-β3-mediated chondrogenesis of BMSCs and promoting articular cartilage repair ○ Emilio Satoshi Hara 1, Mitsuaki Ono 1, Hai Thanh Pham 1, Marian F. Young 2, Satoshi Kubota 3, Masaharu Takigawa 4, Takuo Kuboki 1 (Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 1, National Institutes of Health（NIH）; National Institute of Dental and Craniofacial Research（NIDCR）2, Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 3, Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School 4) O-021 The impact of potent biomineralization inhibitors on the progression of ossification of spinal ligaments in mice model ○ Shigeto Hiratsuka, Masahiko Takahata, Hiroki Hamano, Tomohiro Shimizu, Yusuke Kameda, Masahiro Ota, Norimasa Iwasaki (Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine) O-022 Stromal cell-derived factor-1 mediates the changes of bone marrow stem cells during bone repair process ○ Kiyotaka Okada 1, Naoyuki Kawao 1, Yukinori Tamura 1, Masato Yano 1, Shinji Kurashimo 2, Katsumi Okumoto 2, Kotarou Kojima 1, Hiroshi Kaji 1 (Department of Physiology and Regenerative Medicine, Kinki University Faculty of Medicine 1, Life Science Research Institute, Kinki University Faculty of Medicine 2) O-023 A transcription factor Zfhx4 regulates the late stage of endochondral ossification by interacting with Osterix ○ Eriko Nakamura 1, Kenji Hata 1, Michiko Yoshida 1, Tomohiko Murakami 1, Yoshifumi Takahata 1, Makoto Abe 2, Toshiyuki Yoneda 1,3, Riko Nishimura 1 (Department of Molecular and Cellular Biochemistry, Osaka University Graduate of Dentistry 1, Department of Oral Anatomy and Developmental Biology, Osaka University Graduate of Dentistry 2, Division of Hematology/Oncology, Indiana University School of Medicine 3) － 256 － O-024 The regulation of ciliary protein BBS3 during the craniofacial skeletogenesis ○ Makiri Kawasaki 1, Tadayoshi Hayata 2, Yayoi Izu 1, Yoichi Ezura 1, Masaki Noda 1 (Department of Molecular Pharmacology, Tokyo Medical and Dental University 1, PhD program in Life Science Innovation Program, University of Tsukuba 2) O-025 Essential roles of H3K9MTases G9 during tooth development ○ Taichi Kamiunten 1, Akemi Shimada 2, Hisashi Ideno 2, Yoshiki Nakamura 1, Makoto Tachibana 4, Hiroshi Kimura 3, Kazuhisa Nakashima 2, Akira Nifuji 2 (Department of Orthod, School of Dental Medicine, Tsurumi University 1, Department of Pharmacology, School of Dental Medicine, Tsurumi University 2, School and Graduate School of Bioscience and Biotechnology Tokyo Institute of Technology3, Institute for Enzyme Research, The University of Tokushima 4) O-026 Function of transcriptional factor Mkx in periodontal ligament ○ Naoki Koda 1,2, Masahiro Shinohara 1, Shizuko Ichinose 3, Keiji Moriyama 2, Hiroshi Asahara 1 (Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University 1, Maxillofacial Orthognathics, Department of Maxillofacial Reconstraction and Function, Division of Maxillofacial/Neck Reconstraction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University 2, Research Center for Medical and Dental Sciences, Tokyo Medical and Dental University 3) O-027 Chanzime TRPM7 plays an important role in tooth mineralization ○ Kayoko Ogata 1,2, Hidefumi Fukushima 1, Fujio Okamoto 1, Kyoko Oka 2, Katsuyuki Nagashima 1,3, Masao Ozaki 2, Koji Okabe 1 (Section of Cellular Physiology, Department of Physiological, Science and Molecular Biology, Fukuoka Dental College 1, Section of Pediatric Dentistry, Department of Oral Growth & Development, Fukuoka Dental College 2, Section of Oral Surgery, Department of Oral & Maxillofacial Surgery, Fukuoka Dental College 3) O-028 Comprehensive analysis of genes expressed in human dental pulp cells treated with bFGF aiming at curing spinal cord injury ○ Ken Sugiyama 1, Tomoko Kawaguchi 1, Ken-ichi Tezuka 2 (Department of Oral and Maxillofacial Science, Gifu University Graduate School of Medicine 1, Department of Tissue and Organ Development, Gifu University Graduate School of Medicine 2) O-029 Altered Palatal Wound Healing and T Cell-Dependent Immune System by Anti-RANKL Antibody Treatment ○ Shinichiro Kuroshima 1,2, Junro Yamashita 2 (Oral & Maxillofacial Implant Center, Nagasaki University Hospital 1, Division of Prosthodontics, Department of Biologic Materials and Sciences, University of Michigan, School of Dentistry 2) O-030 Osteocyte derived sclerostin enhances adipocyte differentiation in 3T3-L1 preadipocytes ○ Mayumi Ukita 1,2, Taihiko Yamaguchi 1, Masato Tamura 2 (Department of Crown and Bridge Prosthodontics, Graduate School of Dental Medicine, Hokkaido University 1, Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University 2) O-031 Role of FKBP12 in signal transduction by mutant ALK2 responsible for Fibrodysplasia Ossificans Progressiva ○ Aiko Machiya 1,2, Mai Fujimoto 1,2, Sho Tsukamoto 1, Kenji Osawa 1, Satoshi Ohte 1, Naoto Suda 2, Takenobu Katagiri 1 (Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University 1, Division of Orthodontics, Department of Human Development and Fostering, Meikai University School of Dentistry 2) O-032 Osteoclast differentiation and survival by the proapoptotic mediator TRAIL ○ Hirofumi Tenshin 1,2, Jumpei Teramachi 2,3, Asuka Oda 2, Ryota Amachi 1,2, Masahiro Hiasa 2,4, Keiichirou Watanabe 1,2, Shingen Nakamura 2, Hirokazu Miki 5, Itsuro Endou 2, Eiji Tanaka 1, Toshio Matsumoto 6, Masahiro Abe 2 (Department of Orthodontics and Dentofacial Orthopedics, Institute of Health Biosciences, Tokushima University Graduate School 1, Department of Medicine and Bioregulatory Sciences, Tokushima University Graduate School 2, Department of Histology and Oral Histology, Tokushima University Graduate School 3, Department of Biomaterials and Bioengineering, Tokushima University Graduate School 4, Division of Transfusion and Cell Therapy Medicine, Tokushima University Hospital 5, Fujii Memorial Institute of Medical Sciences, Tokushima University 6) O-033 TAK-1 is a pivotal therapeutic target against myeloma progression and bone destruction ○ Jumpei Teramachi 1,2, Masahiro Hiasa 2,3, Asuka Oda 2, Hirofumi Tenshin 2,4, Ryota Amachi 2,4, Shingen Nakamura 2, Hirokazu Miki 5, Itsuro Endo 2, Tatsuji Haneji 1, Toshio Matsumoto 6, Masahiro Abe 2 (Department of Histology and Oral Histology, Institute of Health Biosciences, Tokushima University Graduate School 1, Department of Medicine and Bioregulatory Sciences, Tokushima University Graduate School 2, Department of Biomaterials and Bioengineering, Tokushima University Graduate School 3, Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School 4, Division of Transfusion and Cell Therapy Medicine, Tokushima University Hospital5, Fujii Memorial Institute of Medical Sciences, Tokushima University 6) O-034 Up-regulation of TRPV1 in myeloma cells to adapt to an acidic microenvironment ○ Ryota Amachi 1,2, Masahiro Hiasa 1,2,3, Jumpei Teramachi 2,4, Asuka Oda 2, Keiichiro Watanabe 1,2, Hirofumi Tenshin 1,2, Shingen Nakamura 2, Hirokazu Miki 2, Takeshi Kondo 2, Itsuro Endo 2, Eiji Tanaka 1, Toshio Matsumoto 5, Masahiro Abe 2 (Department of Orthodontics and Dentofacial Orthopedics, Tokushima University 1, Department of Medicine and Bioregulatory Sciences, Tokushima University 2, Department of Biomaterials and Bioengineering, Tokushima University 3, Deptartment of Histology and Oral Historogy, Tokushima University 4, Fujii Memorial Institute of Medical Sciences, Tokushima University 5) － 257 － O-035 Therapeutic impact of Pim inhibitors on myeloma bone disease: Pivotal role of Pim-2 kinase in stimulation of osteoclastogenesis ○ Jumpei Teramachi 1,2, Masahiro Hiasa 2,3, Asuka Oda 2, Hirofumi Tenshin 2,4, Ryota Amachi 2,4, Shingen Nakamura 2, Hirokazu Miki 5, Itsuro Endo 2, Tatsuji Haneji 1, Toshio Matsumoto 6, Masahiro Abe 2 (Department of Histology and Oral Histology, Institute of Health Biosciences, Tokushima University Graduate School 1, Department of Medicine and Bioregulatory Sciences, Tokushima University Graduate School 2, Department of Biomaterials and Bioengineering, Tokushima University Graduate School 3, Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School 4, Division of Transfusion and Cell Therapy Medicine, Tokushima University Hospital 5, Fujii Memorial Institute of Medical Sciences, Tokushima University 6) O-036 EpCAM Promotes Bone Metastases of Breast Cancer by Conferring Cancer Stem-like and Epithelial Properties ○ Toru Hiraga, Hiroaki Nakamura (Department of Histology and Cell Biology, Matsumoto Dental University) O-037 Effect of CCN2 on the osteocyte function, which regulates the osteoclast formation ○ Takashi Nishida 1, Satoshi Kubota 1,2, Masaharu Takigawa 2 (Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 1, Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School 2) O-038 Osteocytes exacerbate bone pain via interactions with sensory neurons ○ Hiasa Masahiro 1, Tatsuo Okui 1, Yuki Nagata 1, Toshiyuki Yoneda 1,2 (Division of Hematology/Oncology, Indiana University School of Medicine 1, Department of Biochemistry, Osaka University Graduate School of Dentistry 2) O-039 Sclerostin expression is induced by transduction of four transcription factors ATF3, KLF4, PAX4 and SP7 and regulated by PTH or hypoxia in human fibroblasts ○ Makoto Fujiwara 1, Yasuhisa Ohata 1, Taichi Kitaoka 1, Takuo Kubota 1, Yasuji Kitabatake 1, Noriyuki Namba 1, Toshimi Michigami 2, Keiichi Ozono 1 (Department of Pediatrics, Osaka University Graduate School of Medicine 1, Osaka Medical Center and Research Institute for Maternal and Child Health 2) O-040 Targeted Disruption of BMP Signaling Through Type IA Receptor（BMPRIA）in Osteocyte Suppresses SOST and RANKL, Leading to a Dramatic Increase in Bone Density and Mechanical Strength ○ Nobuhiro Kamiya (Sports Medicine, Tenri University) O-041 Intravital bone imaging by two-photon excitation microscopy to identify osteocytic osteolysis in vivo ○ Hiroshige Sano 1,2, Junichi Kikuta 1, Masayuki Furuya 1, Naoki Kondo 2, Naoto Endo 2, Masaru Ishii 1 (Department of Immunology and CZell Biology, Osaka University 1, Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences 2) O-042 Ultrastructural examination on bone matrix surrounding osteocytic lacunae treated with parathyroid hormone, lactation and low calcium diet in mice ○ Hiromi Hongo 1, Masami Saito 2, Nobuyuki Udagawa 3, Norio Amizuka 1 (Departments of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University 1, Bruker AXS k. K. 2, Department of Biochemistry, Matsumoto Dental University 3) O-043 Ttw mice, rodent OPLL models, exhibited high serum FGF23 levels ○ Ryuichi Watanabe, Masaya Nakamura, Morio Matsumoto, Takeshi Miyamoto (Department of Orthopaedic Surgery, Keio University School of Medicine) O-044 ADAM10 is indispensable for maintenance of the muscle satellite cell pool ○ Sakiko Mizuno, Masaki Yoda, Morio Matsumoto, Masaya Nakamura, Keisuke Horiuchi (Keio University School of Medicine) O-045 Histone methyltransferase G9a plays important roles in growth and differentiation of tenocytes in mice ○ Satoshi Wada 1, Hisashi Ideno 2, Akemi Shimada 2, Taichi Kamiunten 1, Yoshiki Nakamura 1, Kazuhisa Nakashima 2, Hiroshi Kimura 3, Makoto Tachibana 4, Akira Nifuji 2 (Department of Orthodontics, Tsurumi University School of Dental Medicine 1, Department of Pharmacology, Tsurumi University School of Dental Medicine 2, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology 3, The Institute of Enzyme Research, The University of Tokushima 4) O-046 Novel vandidate genes related to ossification of the posterior longitudinal ligament of spine ○ Masanori Saito, Hiroyuki Inose (Department of Orthopaedic surgery ,University of TMDU) O-047 Regulation of bony outgrowth by Annexin A5 at tendon/ligament insertion sites ○ Akemi Shimada 1, Yoshinori Arai 2, Satoshi Wada 3, Hisashi Ideno 1, Taichi Kamiunten 3, Kazuhisa Nakashima 1, Koichiro Komatsu 1, Teruhito Yamashita 4, Yoichi Ezura 5, Norio Amizuka 6, Yoshiki Nakamura 3, Akira Nifuji 1 (Dep. of Pharmacol., Tsurumi Univ. Sch. of Dent. Med.1, Nihon Univ. Sch. of Dent. 2, Dep. of Orthod., Tsurumi Univ. Sch. of Dent. Med.3, Div. of Hard Tissue Res., Inst. for Oral Sci. Matsumoto Dent. Univ. 4, Mol. Pharmacol., Adv. Mol. Med., Med. Res. Inst., Tokyo Med. Dent. Univ. 5, Dep. of Dev. Biol. of Hard Tissue, Grad. Sch. of Dent. Med., Hokkaido Univ. 6) － 258 － O-048 TLE3 regulates transcriptional activity of MyoD ○ Shoichiro Kokabu 1, Tsuyoshi Sato 2, Yuichiro Enoki 2, Takenobu Katagiri 3, Eijiro Jimi 1 (Division of Molecular Signaling and Biochemistry, Kyushu Dental University 1, Divison of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University 2, Divison of Pathphysiology, Research Center for Genomic Medicine, Saitama Medical University 3) O-049 Effects of bisphosphonate for pain-related behavior and immunohistochemical analysis in the hind limb-unloaded mouse model of disuse osteoporosis ○ Taro Nakagawa 1,2, Hiroki Wakabayashi 1, Yohei Naito 1, Syo Kato 1, Akihiro Sudo 1 (Department of Orthopaedic Surgery Mie University Graduate School of Medicine 1, Owase General Hospital 2) O-050 Induction of skeletal pain related to regional osteoporosis change of lower limb in tail-suspension mouse model ○ Takayuki Dohke, Kousuke Iba, Kumiko Kanaya, Shunichiro Okazaki, Yasuhisa Abe, Megumi Hanaka, Toshihiko Yamashita (Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine) O-051 Factors that predict the prognosis of incomplete atypical femoral fractures ○ Yoshitomo Saita 1, Akio Kanda 4, Yuji Makino 3, Yuko Sakamoto 2, Daichi Morikawa 2, Hidetoshi Nojiri 3, Akira Isaka 5, Kazuo Kaneko 1 (Department of Orthopaedics, Juntendo University 1, Department of Orthopaedics, Juntendo Nerima Hospital 2, Department of Orthopaedics, Juntendo Tokyo Koto Geriatric Medical Center3, Department of Orthopaedics, Juntendo Shizuoka Hospital4, Department of Orthopaedics, Koto Hospital 5) O-052 Mechanical changes in the vertebral bodies over time and changes in bone metabolism markers by anti-RANKL antibody ○ Kazuhide Inage, Kazuki Fujimoto, Kazuyo Yamauchi, Sumihisa Orita, Miyako Suzuki, Go Kubota, Takeshi Sainoh, Jun Sato, Yasuhiro Shiga, Koki Abe, Hirohito Kanamoto, Seiji Ohtori (Dept. of Orthopaedic Surgery, Graduate School of Medicine, Chiba University) O-053 The nature of low back pain due to osteoporosis without fracture: a multicenter prospective study on the effect of monthly minodronic acid hydrate ○ Kazuki Fujimoto, Kazuhide Inage, Kazuyo Yamauchi, Sumihisa Orita, Miyako Suzuki, Gou Kubota, Takeshi Sainoh, Jun Sato, Yasuhiro Shiga, Koki Abe, Hirohito Kanamoto, Seiji Ohtori (Department of Orthopaedic Surgery, Chiba University) O-054 Estimated lumbar, femur bone mineral densities and the corresponding bone loss rates of postmenopausal Japanese women in future ○ Takehisa Yamamoto 1, Noriko Yoshimura 2, Takeshi Ibata 3 (Department of Pediatrics, Minoh City Hospital 1, The University of Tokyo Hospital 2, Department of Internal Medicine, Minoh City Hospital 3) O-055 Donepezil, an acetylcholinesterase inhibitor, prevents RANKL-induced rapid bone loss by strongly suppressing osteoclast formation and function ○ Tsuyoshi Sato 1, Masahiko Okubo 1, Yuichiro Enoki 1, Shoichiro Kokabu 2, Michihiko Usui 3, Masahito Matsumoto 4, Toshihiro Sugiyama 5, Hiromi Oda 5, Tatsuo Suda 4, Tetsuya Yoda 1 (Department of Oral and Maxillofacial Surgery, Saitama Medical University 1, Division of Molecular Signaling and Biochemistry, Kyushu Dental University 2, Department of Periodontology, Kyushu Dental University 3, Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University 4, Department of Orthopaedic Surgery, Saitama Medical University 5) O-056 Administration of oxygen ultra-fine bubble water ameliorates glucocorticoid-induced osteoporosis of mice by inhibiting osteoclasts differentiation ○ Takaaki Noguchi 1, Kosuke Ebina 1, Tokimitsu Morimoto 1, Makoto Hirao 1, Jun Hashimoto 2, Hideki Yoshikawa 1 (Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka University 1, Department of Rheumatology, National Hospital Organization, Osaka Minami Medical Center 2) O-057 BONE HEALTH IN GLUCOCORTICOIDS TREATED MEN AND WOMEN ○ Renaud Winzenrieth 1, Edward Leib 2 (R&D Department, Med-Imaps, Merignac, France 1, Dept. of Medicine, University of Vermont College of Medicine, Burlington, VT, USA 2) O-058 Validation of Japanese Guideline for glucocorticoid-induced osteoporosis -Is it useful for severe cases?○ Ikuko Tanaka 1, Mari Ushikubo 2, Shigenori Tamaki 1, Hisaji Oshima 2 (Nagoya Rheumatology Clinic 1, Department of Connective Tissue Diseases, Tokyo Medical Center 2) O-059 Fasting plasma glucose and glycated hemoglobin A1c levels were correlated positively with bone density and inversely with trabecular bone score in Japanese elderly men - Fujiwara-kyo Osteoporosis Risk in Men Study ○ Masayuki Iki 1, Yuki Fujita 1, Junko Tamaki 2, Katsuyasu Kouda 1, Akiko Yura 1, Yuho Sato 3, Renaud Winzenrieth 4, Jong-Song Moon 5, Nozomi Okamoto 6, Norio Kurumanani 6 (Department of Public Health, Kinki University Faculty of Medicine 1, Department of Hygine and Public Health, Osaka Medical College 2, Department of Health and Nutrition, Jin-ai University Faculty of Human Life 3, Med-Imaps 4, Department of Nursing and Medical Care, Faculty of Health Science, Kio University 5, Department of Community Health and Epidemiology, Nara Medical University School of Medicine 6) － 259 － O-060 Trabecular Bone Score（TBS）is associated with pulmonary function and severe vertebral fractures in male subjects with COPD（chronic obstructive pulmonary disease） ○ Reiko Watanabe, Nobuyuki Tai, Daisuke Inoue, Ryo Okazaki (Third Department of Medicine, Teikyo University Chiba Medical Center) O-061 Mutual association between sarcopenia and osteoporosis: second visit of the ROAD study ○ Noriko Yoshimura 1, Shigeyuki Muraki 2, Hiroyuki Oka 3, Sakae Tanaka 4, Hiroshi Kawaguchi 5, Kozo Nakamura 6, Toru Akune 6 (Department of Joint Disease Research, 22nd Century Medical and Research Center, The University of Tokyo 1, Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, The University of Tokyo 2, Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center 3, Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo 4, JCHO Tokyo Shinjuku Medical Center 5, National Rehabilitation Center for Persons with Disabilities 6) O-062 Baseline bone markers in male subjects undergoing coronary angiography predict all-cause mortality: CHIBA（Coronary Heart Disease of Ischemia and Bone Association）Study ○ Nobuyuki Tai, Reiko Watanabe, Ryo Okazaki, Daisuke Inoue (Third Depatment of Medicine, Teikyo University Chiba Medical Center) O-063 Effects of denosumab on bone mineral density and bone turnover in osteoporosis in rheumatoid arthritis patients ○ Ichiro Nakamura 1,2, Eijiro Jimi 3 (Faculty of Medical Science for Health, Teikyo Medical University 1, Department of Rheumatology, JCHO Yugawara Hospital 2, Department of Molecular Signaling and Biochemistry, Kyushu Dental College 3) O-064 Collagen VI and XII complex regulates osteoblast communication network ○ Yayoi Izu, Yoichi Ezura, Masaki Noda (Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University) O-065 Osteoclasts' activation just under the growth plate is reduced by continuous injection of PTH ○ Nobuhito Nango 1, Shogo Kubota 1, Wataru Yashiro 2, Atsushi Momose 2, Shizuko Ichinose 4, Koichi Matsuo 3 (Ratoc System Engineering Co., Ltd. 1, Institute of Multidisciplinary Research for Advanced Materials, Tohoku University 2, Laboratory of Cell and Tissue Biology, Keio University School of Medicine 3, Research Center for Medical and Dental Sciences, Tokyo Medical and Dental University 4) O-066 Mesenchymal stem cells-derived exosomes promote bone repair in mouse model ○ Taisuke Furuta 1, Shigeru Miyaki 2, Hiroyuki Ishitobi 2, Mitsuo Ochi 1 (Department of Orthopaedics Surgery, Hiroshima University 1, Department of Regenerative Medicine, Hiroshima University 2) O-067 Function of Periostin in the fracture healing of medaka caudal fin ray ○ Masaki Takeda, Kazuhiro Takeyama, Akiko Mantoku, Masahiro Chatani, Akira Kudo (Department of Biological Information, Tokyo Institute of Technology) O-068 Atoh8, a target gene of BMP signaling, inhibits osteoblast differentiation ○ Yuhei Yahiro 1,2, Shingo Maeda 1, Naohiro Shinohara 1,2, Masahiro Yokouchi 2, Ichiro Kawamura 1,2, Yasuhiro Ishidou 1,2, Setsuro Komiya 1,2 (Department of Medical Joint Materials, University of Kagoshima 1, Department of Orthopedics, University of Kagoshima 2) O-069 The physiological significance of Runx2 in intramembranous ossification –Analysis using Runx2 conditional knockout mice○ Takeshi Takarada, Eiichi Hinoi, Yukio Yoneda (Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Medical, Pharmaceutical and Health Sciences) O-070 Histological assessment on bone in transgenic mice overexpressing parathyroid hormone-related peptide（PTHrP） driven by type1 collagen promoter ○ Tomomaya Yamamoto 1, Tomoka Hasegawa 1, Nanae Yamazaki 1, Kimimitsu Oda 2, Toshifumi Komori 3, Norio Amizuka 1 (Departoment Hard Tissue, Hokkaido University 1, Division Biochemistry, Nigata University 2, Department of Cell Biology, Nagasaki University 3) O-071 Deletion of histone methyltransferase G9a causes impaired bone formation in mice ○ Hisashi Ideno 1,2, Koichiro Komatsu 1, Akemi Simada 1, Taichi Kamiunten 3, Yoshinori Arai 4, Kazuhisa Nakashima 1, Ryoko Araki 2, Yoshiki Nakamura 3, Masumi Abe 2, Makoto Tachibana 5, Hiroshi Kimura 6, Akira Nifuji 1,2 (Department of Pharmacology, Tsurumi University School of Dental Medicine 1, Transcriptome Research Group, National Institute of Radiological Sciences 2, Department of Orthodontics, Tsurumi University School of Dental Medicine 3, Nihon University School of Dentistry 4, Institute for Enzyme Research, The University of Tokushima 5, Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology 6) O-072 Nck adaptors maintains bone mass by promoting osteoblastic migration ○ Smriti Aryal A.C, Yoichi Ezura, Yayoi Izu, Masaki Noda (Department of Molecular Pharmacology, Tokyo Medical and Dental University) － 260 － O-073 Indoxyl sulfate regulates bone metabolism ○ Tsukasa Tominari 1, Chiho Matsumoto 1, Michiko Hirata 1, Chisato Miyaura 1,2, Masaki Inada 1,2 (Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology 1, Cooperative Major of Advanced Health Science, Tokyo University of Agriculture and Technology 2) O-074 Collagen fiber orientation in the femur of rat with chronic kidney disease ○ Teppei Ito, Yuya Kanehira, Kyosuke Kanazawa, Hiromi Kimura-Suda (Chitose Institute of Science and Technology) O-075 The Effect of parathyroid hormone intermittent injection on fragility bone disease with chronic kidney disease ○ Yoshiko Iwasaki 1, Junichiro Kazama 2, Masafumi Fukagawa 3 (Oita University of Nursing and Health Sciences 1, Niigata University Medical & Dental Hospital 2, Tokai University School of Medicine 3) O-076 It is impossible to distinguish between physiologic leg bowing and Rickets due to vitamin D deficiency only by radiography ○ Yuko Sakamoto 1, Muneaki Ishijima 2, Sung-Gon Kim 1, Koichi Kamata 1, Koichi Maeda 1, Daichi Morikawa 1, Masahiko Nozawa 1, Kazuo Kaneko 2 (Dept. of Orthopaedics Juntendo Univ. Nerima Hosp. 1, Dept. of Medicine for Orthopaedics and Motor Organ, Juntendo Univ. Graduate School of Medicine 2) O-077 A metabolic disorder of phosphate and vitamin D in a case of XLH complicated by ADPKD ○ Satomi Kajita 1, Takehisa Yamamoto 1, Shinji Takeyari 2, Hirofumi Nakayama 2, Kousei Hasegawa 3, Taichi Kitaoka 2, Yasuhisa Ohata 2, Takuo Kubota 2, Naoko Tsugawa 4, Toshimi Michigami 5, Keiichi Ozono 2, Tsunesuke Shimotsuji 1 (Department of Pediatrics, Minoh City Hospital 1, Department of Pediatrics, Graduate School of Medicine, Osaka University 2, Department of Pediatrics, Graduate School of Medicine, Density and Phamaceutical Sciences, Okayama University 3, Hygienic Sciences, Kobe Phamaceutical University 4, Osaka Medical Center and Research Institute for Maternal and Child Health 5) O-078 A case of tumor-induced osteomalacia caused by a parotid tumor ○ Yuichi Takashi 1, Yuka Kinoshita 1, Nobuaki Ito 1, Manabu Taguchi 1, Seiji Fukumoto 1,2 (Division of Nephrology and Endocrinology, The University of Tokyo Hosipital 1, Fujii Memorial Institute of Medical Sciences, The University of Tokushima 2) O-079 Regulation control of FGF23 transcription and production in bone by active vitamin D analog ○ Mitsuru Yashiro, Masaki Ohya, Takashi Shigematsu (Wakayama Medical University, Department of Internal Medicine, Division of Nephrology) O-080 The significance of serum FGF23 concentration in patients with vitamin D deficiency and PTH resistance ○ Yuka Kinoshita 1, Yuichi Takashi 1, Nobuaki Ito 1, Manabu Taguchi 1, Seiji Fukumoto 2 (Division of Nephrology and Endocrinology, The University of Tokyo Hospital 1, Fujii Memorial Institute of Medical Sciences, The University of Tokushima 2) O-081 Oncogenic osteomalacia tumor secreting FGF-23 expressing the osteoblast/osteocyte specific genes ○ Masaya Ohara, Yasuo Imanishi, Yuki Nagata, Katsuhito Mori, Masaaki Inaba (Internal Medecine, Osaka City of University) O-082 Histochemical examination on bone tissue of postmenopausal model rats with switched administration from PTH to eldecalcitol ○ Hiromi Hongo 1, Sadaoki Sakai 2, Tomomaya Yamamoto 1, Tomoka Hasegawa 1, Satoshi Takeda 2, Kouichi Endo 2, Kazushi Saito 3, Norio Amizuka 1 (Departments of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University 1, Product Research Dept. Chugai Pharmaceutical Co., Ltd. 2, Medical Science Dept. Chugai Pharmaceutical Co., Ltd. 3) O-083 Comparative effects of teriparatide and zoledronic acid on the pathology combined hyperostosis and osteoporosis in the twy mice model for diffuse idiopathic skeletal hyperostosis ○ Hiroki Hamano, Masahiko Takahata, Masahiro Ota, Shigeto Hiratsuka, Tomohiro Simizu, Yusuke Kameda, Norimasa Iwasaki (Hokkaido University, Department of Orthopedic Surgery, Graduate School of Medicine) O-084 Effect of teriparatide on pain-like behavior in ovariectomized mice ○ Takayuki Dohke, Kousuke Iba, Kumiko Kanaya, Yasuhisa Abe, Megumi Hanaka, Toshihiko Yamashita (Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine) O-085 Total 25-hydroxyvitamin D predicts fracture risk in Japanese women –JPOS Cohort Study ○ Junko Tamaki 1, Masayuki Iki 2, Yuho Sato 3, Etsuko Kajita 4, Harumi Nishino 5, Takashi Akiba 6, Toshio Mastumoto 7, Sadanobu Kagamimori 8, Yoshiko Kagawa 9, Hidemo Yoneshima 10 (Department of Hygiene & Public Health 1, Department of Public Health, Kinki University Faculty of Medicine 2, Department of Domestic Sciences, Jin-ai University3, Department of Public Health and Home Nursing, Nagoya University School of Health Sciences 4, Nippon Express Co., Inc., Toyama Branch 5, Department of Blood Purification and Internal Medicine, Kidney Center Tokyo Women's Medical University 6, University of Tokushima Fuji Memorial Institute of Medical Sciences 7, University of Toyama 8, Kagawa Nutrition University 9, Shuuwa General Hospital 10) － 261 － O-086 Comparison of effects of bisphosphonate and denosumab administration after daily teriparatide administration ○ Kosuke Ebina 1, Jun Hashimoto 2, Masafumi Kashii 1, Makoto Hirao 1, Takaaki Noguchi 1, Hideki Yoshikawa 1 (Osaka University, Graduate School of Medicine 1, Department of Rheumatology, National Hospital Organization, Osaka Minami Medical Center 2) O-087 Comparative effectiveness of raloxifene or eldecalcitol versus alendronate in preventing non-vertebral fractures in Japanese women with osteoporosis: retrospective cohort study using a hospital claims database ○ Sakae Tanaka 1, Takanori Yamamoto 2, Saeko Fujiwara 3 (Department of Orthopaedic Surgery, Graduate School of Medicine, University of Tokyo 1, Medical Science, Lilly Research Laboratories, Medical Development Unit Japan, Eli Lilly Japan K.K. 2, Health Management and Promotion Center, Hiroshima Atomic Bomb Casualty Council 3) O-088 A Sp7/Dlx transcriptional complex regulates osteoblast differentiation ○ Hironori Hojo 1, Shinsuke Ohba 2,3, Yuichi Tei 2,3 (University of Southern California 1, Department of Bioengineering, The University of Tokyo 2, Center for Disease Biology and Integrative Medicine, The University of Tokyo 3) O-089 The transcriptional modulator Interferon-related developmental regulator 1 coordinately regulates bone homeostasis ○ Takashi Iezaki, Yukio Yoneda, Eiichi Hinoi (Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology) O-090 Mammalian-type Brn-1/Pou3f3 with homopolymeric amino acid repeats is essential for stress-induced bone metabolic changes in mice ○ Atsushi Igarashi, Koichi Matsuo (Keio University School of Medicine) O-091 Construction of a novel gene library related to osteogenic disease using an exchangeable gene trap mutagenesis ○ Shihoko Nakamura, Tomohisa Sekimoto, Taro Funamoto, Syuji Kurogi, Tomomi Ota, Takuya Nagai, Etsuo Chosa (Department of Orthopaedic Surgery, Miyazaki University) O-092 Different regulation of limb development by p63 transcript variants ○ Manabu Kawata 1, Yuki Taniguchi 1, Keita Okada 1, Song Ho Chang 1, Fumiko Yano 2, Sakae Tanaka 1, Taku Saito 1,2 (Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo 1, Department of Bone and Cartilage Regenerative Medicine, The University of Tokyo Hospital 2) O-093 Sox9 regulates transcription through two distinct modes of action on the chondrocyte genome ○ Shinsuke Ohba 1,2, Hironori Hojo 3, Yuichi Tei 1,2 (Department of Bioengineering, The University of Tokyo Graduate School of Engineering1, Center for Disease Biology and Integrative Medicine, The University of Tokyo Graduate School of Medicine2, University of Southern California 3) O-094 Role of Plasminogen Activator Inhibitor-1 in the Pathogenesis of Glucocorticoid-Induced Osteoporosis, Diabetes and Muscle Wasting in Mice ○ Yukinori Tamura 1, Naoyuki Kawao 1, Masato Yano 1, Kiyotaka Okada 1, Katsumi Okumoto 2, Yasutaka Chiba 3, Osamu Matsuo 4, Hiroshi Kaji 1 (Department of Physiology and Regenerative Medicine, Kinki University Faculty of Medicine 1, Life Science Research Institute, Kinki University 2, Clinical Research Center, Kinki Univresity Hospital 3, Kinki University Faculty of Medicine 4) O-095 Iorganic phosphate activates Akt/mTORC1 pathway by suppressing PTEN and shortens life span in Klotho-deficient mouse ○ Masanobu Kawai 1, Saori Kinoshita 1, Keiichi Ozono 2, Toshimi Michigami 1 (Department of Bone and Mineral Researchm Osaka Medical Center and Research Institute for Maternal and Child Health1, Department of Pediatrics, Osaka University Graduate School of Medicine 2) O-096 Osteoprotegerin protects pancreatic β-cells from insulin exhaustion in inflammatory conditions ○ Yukiko Kuroda, Koichi Matsuo (Laboratory of Cell and Tissue Biology, Keio University School of Medicine) O-097 α2-antiplasimin is involved in the pathogenesis of postmenopausal osteoporosis ○ Akihito Shiomi 1,2, Naoyuki Kawao 2, Masato Yano 2, Kiyotaka Okada 2, Yukinori Tamura 2, Katsumi Okumoto 3, Osamu Matsuo 2, Masao Akagi 1, Hiroshi Kaji 2 (Department of Orthopaedic Surgery, Kindai University Faculty of Medicine 1, Department of Physiology and Regenerative Medicine, Kinki University Faculty 2, Life Science Research Institute, Kinki University 3) O-098 Regulation of renal α-klotho expression by dietary phosphate and the onset of ectopic calcification ○ Shiori Fukuda 1, Hironori Yamamoto 1,2, Mari Nakao 1, Eiji Takeda 1, Yutaka Taketani 1 (Departments of Clinical Nutrition and Food Management, Institute of Health Biosciences, University of Tokushima Graduate School1, Department of Health and Nutrition, Faculty of Human Life, Jin-ai University 2) O-099 Eldecalcitol-induced increase in bone mass is mediated by VDR in osteoblasts ○ Yuko Nakamichi 1, Toshihide Mizoguchi 1, Yoko Yamamoto 2, Suguru Harada 3, Hitoshi Saito 3, Yasuhiro Kobayashi 1, Shigeaki Kato 4, Tatsuo Suda 5, Nobuyuki Udagawa 6, Naoyuki Takahashi 1 (Institute for Oral Science, Matsumoto Dental University 1, The University of Tokyo Hospital 2, Chugai Pharmaceutical Co., Ltd. 3, Soma Central Hospital 4, Research Center for Genomic Medicine, Saitama Medical University 5, Department of Biochemistry, Matsumoto Dental University 6) － 262 － O-100 Bone resorption suppresses sclerostin expression in osteocytes and promotes bone formation ○ Masanori Koide 1, Yasuhiro Kobayashi 1, Teruhito Yamashita 1, Shunsuke Uehara 2, Yuki Ozaki 1, Tadahiro Iimura 3, Midori Nakamura 2, Hisataka Yasuda 4, Naoyuki Takahashi 1, Nobuyuki Udagawa 1,2 (Institute for Oral Science, Matsumoto Dental University 1, Department of Biochemistry, Matsumoto Dental University 2, Division of Bio-Imaging, Proteo-Science Center（PROS）, Ehime University 3, Planning & Development, Bioindustry Division, Oriental Yeast Co., Ltd 4) O-101 Role of TAF12 in the Increased VDR Activity in Paget's Disease of Bone ○ Yuji Inagaki, Yuki Nagata, Jumpei Teramachi, G David Roodman, Noriyoshi Kurihara (Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis IN, USA) O-102 WISP1/CCN4 controls bone metabolism ○ Azusa Maeda 1,2, Mitsuaki Ono 1, Takuo Kuboki 1, Marian Young 2 (Okayama University Graduate School, Dept. of Oral Rehabilitation and Regenerative Medicine 1, NIDCR, National Institutes of Health（NIH）2) O-103 Immune complexes regulate osteoclastogenesis ○ Takako Koga 1, Eriko Sumiya 2,3, Masamichi Takami 1, Hiroshi Takayanagi 2,3 (Department of Phamacoogy, School of Density, Showa University 1, Department of Immunology, Graduate School of Medicine and Faculty of Medicine 2, JST ERATO Takayanagi Osteonetwork Project 3) O-104 Roles of C-C chemokine receptor 5, a co-receptor of HIV, -mediated signal in locomotion of osteoclasts and bone resorption ○ Ji-Won Lee 1, Akiyoshi Hoshino 2, Kazuki Inoue 3, Shunsuke Uehara 4, Yasuhiro Kobayashi 5, Masako Ito 6, Akira Yamaguchi 7, Yuuki Imai 8, Tadahiro Iimura 1 (Division of Bio-Imaging, Proteo-Science Center（PROS）, Ehime University 1, Department of Pathology, Nagoya University Graduate School of Medicine 2, Department of Biological Resources, Integrated Center for Sciences, Ehime University 3, Department of Biochemistry, Matsumoto Dental University 4, Institute for Oral Science, Matsumoto Dental University 5, Medical Work-Life-Balance Center, Nagasaki University Hospital 6, Section of Oral Pathology, Graduate School of Medicine and Dental Sciences, Tokyo Medical and Dental University 7, Division of Integrative Pathophysiology, ProteoScience Center, Graduate School of Medicine, Ehime University 8) O-105 Regulation of osteoclastogenesis by interaction between an endoplasmic reticulum-resident transcription factor Luman and an osteoclast-fusion protein DC-STAMP ○ Soshi Kanemoto 1, Yasuhiro Kobayashi 2, Teruhito Yamashita 2, Takeshi Miyamoto 3, Naoyuki Takahashi 2, Kazunori Imaizumi 1 (Department of Biochemistry, Hiroshima University 1, Institute for Oral Science, Matsumoto Dental University 2, Department of Orthopaedic Surgery, School of Medicine, Keio University 3) Oral Poster Presentation OP-01 Withdrawn of bone and mineral metabolism in chronic kidney disease using parathyroid gland-specific FGFR conditional OP-02 Analysis KO mice （P2-03）○ Kazuki Kawakami , Ai Takeshita , Masayasu Miyajima , Ikuji Hatamura , Kazushige Sakaguchi 1 1 2 3 1 (Department of Molecular Cell Biology and Molecular Medicine Institute of Advanced Medicine Wakayama Medical University1, Laboratory Animal Center Wakayama Medical University 2, Kansai University of Health Sciences 3) PEG10 inhibits enhanced invasive behavior of chondrosarcoma cells OP-03 BMP-induced ○ Naohiro Shinohara , Shingo Maeda , Yuhei Yahiro , Katsuyuki Imamura , Masahiro Yokouchi , Ichiro Kawamura （P1-41）Yasuhiro Ishidou , Setsurou Komiya 1,2 1 1 1,2 2 2 1,2 1,2 , (Department of Medical Joint Materials, Kagoshima University 1, Department of Orthopaedic Surgery, Kagoshima University 2) Small GTPase Cdc42 is crucial for palatal development OP-04 ○ Mutsuko Oshima , Atsushi Yamada , Dai Suzuki , Koutaro Maki , Ryutaro Kamijo （P2-27）(Department of Biochemistry, University of Showa , Department of Orthodontics, University of Showa ) 1,2 1 1 2 1 1 2 Functions of CCN3 on Articular Cartilage OP-05 New ○ Danilo Janune , Tarek Abd El Kader , Eriko Aoyama , Takashi Nishida , Hany Khattab , Satoshi Kubota （P1-47）Masaharu Takigawa 1 1 1 2 1 1 1,2 , (Advanced Research Center for Oral and Craniofacial Sciences, Okayama University 1, Biochemistry and Molecular Dentistry, Okayama University 2) factor for fracture in patients with rheumatoid arthritis is not the disease itself but the use of glucocorticoid –the OP-06 A4thriskyear results of the TOMORROW study（P1-44）○ Yuko Sugioka , Kentaro Inui , Kenji Mamoto , Tadashi Okano , Masahiro Tada , Tatsuya Koike 1 3 3 3 3 1,2 (Center for Senile Degenerative Disorders（CSDD） , Osaka City University Medical School 1, Search Institute for Bone and 2 Arthritis Disease（SINBAD）, Orthopedic Surgery, Osaka City University Medical School 3) inhibits human osteoclastogenesis OP-07 IL-35 ○ Toru Yago, Yuki Nanke, Manabu Kawamoto, Shigeru Kotake （P1-46）(Institute of Rheumatology, Tokyo Women's Medical University) － 263 － Interim report of Drug Use Investigation of Bazedoxifene （Viviant Tablet） OP-08 The ○ Miki Tanigawa , Eriko Uchibori , Etsuya Bando , Yutaka Endo , Luis A Yamamoto （P2-62）(Pfizer Japan Inc. PMS Planning & Operation Group , Pfizer Japan Inc. PMS Date Integration & Operation Group , Pfizer Ⓡ 1 2 3 4 5 1 2 Japan Inc. Data Analysis Reporting Group 3, Pfizer Japan Inc. Clinical Statistics Group 4, Pfizer Japan Inc. GIP Medical Affairs 5) OP-09 Withdrawn therapy with bisphosphonate and eldecalcitol increased calcification of trabecular bone in ovariectomized OP-10 Combination rats （P1-49）○ Hiromi Kimura-Suda , Teppei Ito , Hirotaka Wagatsuma , Tetsuo Yano , Daisuke Inoue 1 1 2 2 3 1 (Chitose Institute of Science and Technology , Ajinomoto Pharmaceuticals Co., Ltd. 2, Teikyo University School of Medicine 3) Between Serum Ferritin and Hemoglobin Levels and Bone Health in Korean Adolescent OP-11 Association ○ Kim Do Hoon , Jung Dong-Wook , Han Kyung-Do , Park Yong-Gyu , Ju Sang-Yhun , Roh Yong-Kyun , Choi Jun-Seok , （P2-61）Lee Jong-Eun , Sang Jung-Eun , Nam Hyo-Yun , Nam Ga-Eun , Yoon Yeo-Joon 1 1 1 2 1 2 1 3 1 4 1 1 (Department of Family Medicine, Korea University, College of Medicine 1, Department of Biostatistics, Catholic University, College of Medicine 2, Department of Family Medicine, Catholic University, College of Medicine 3, Department of Family Medicine, Hallym University, College of Medicine 4) a specific bone pattern exist in patient suffering from Cushing's disease? OP-12 Does ○ Renaud Winzenrieth , Amandine Boisson , Antoine Tabarin , Thierry Schaeverbeke , Nadia Mehsen-Cetre （P2-64）(Rheumatology Department, CHU Pellegrin, Bordeaux, France , R&D Department, Med-Imaps, Merignac, France , 2 1 3 1 1 1 2 Endocrinology Department, CHU Pellegrin, Bordeaux, France 3) of bone turnover markers and bone mineral density using daily teriparatide with or without bisphosphonate OP-13 Changes pre-treatment （P1-53）○ Yukio Nakamura , Mikio Kamimura , Keijiro Mukaiyama , Shota Ikegami , Shigeharu Uchiyama , Hiroyuki Kato 1 2 3 1 1 1 (Department of Orthopaedic Surgery, Shinshu University School of Medicine 1, Kamimura Clinic 2, Department of Orthopaedic Surgery, Azumi General Hospital 3) farnesoid X receptor negatively regulates osteoclastogenesis via JNK dependent PPARγ signaling pathways OP-14 The ○ Ting Zheng, Mijung Yim （P1-07）(Colleage of Pharmacy, Sookmyung Women's University) oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction OP-15 Lectin-like in mice, despite promoting osteoclastogenesis in the steady state （P2-10）○ Junta Ito, Chiyomi Hayashida, Yoko Ohyama, Takuya Sato, Yoshiyuki Hakeda (Division of Oral Anatomy, Meikai University School of Dentistry) of osteoclast differentiation during bone modeling in medaka pharyngeal teeth OP-16 Mechanism ○ Akiko Mantoku , Masahiro Chatani , Kazushi Aono , Keiji Inohaya , Yoshiro Takano , Akira Kudo （P1-01）(Department of Biological Information, Tokyo Institute of Technology , Section of Biostructural Science, Department of 1 1 1 1 2 1 1 Hard Tissue Engineering, Division of Bio-Matrix, Graduate School of Tokyo Medical and Dental University 2) function of internalized RANK in osteoclastogenesis OP-17 The ○ Yuu Taguchi, Jun-ichiro Inoue （P2-22）(The University of Tokyo, The Institute of Medical Science) Role of TRAF6 in differentiation and maturation of osteoclasts OP-18 ○ Yo Yumiketa, Yuu Taguchi, Jun-ichiro Inoue （P2-21）(The University of Tokyo, The Institutes of Medical Science) ER stress sensor OASIS is involved in angiogenesis during bone formation in a coordinated manner with HIF1α OP-19 An ○ Min Cui , Soshi Kanemoto , Yuki Yoshimoto , Chisa Shukunami , Kazunori Imaizumi （P1-21）(Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University , Department of Molecular 1 1 2 2 1 1 2 Biology and Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University ) factor Nfil3/E4BP4 regulates cellular proliferation in response to α1B-adrenergic receptor signaling in OP-20 Transcriptional osteoblasts （P1-34）○ Takao Hirai, Kenjiro Tanaka, Akifumi Togari (Department of Pharmacology, School of Dentistry, Aichi-Gakuin University) The role of Wnt signal modulator gene, sFRP4, in bone formation/metabolism OP-21 ○ Ryuma Haraguchi , Riko Kitazawa , Yuuki Imai , Sohei Kitazawa （P1-35）(Dept. Mol. Pathol., Ehime Univ. , Dept. Diagn. Pathol., Ehime Univ. Hosp. , PROS, Ehime Univ. ) 1 1,2 3 1 1 2 3 and Characterization of Human Osteoblasts From Needle Biopsies Without In Vitro Culture OP-22 Isolation ○ Koji Fujita （P2-44）(Department of Orthopaedic Surgery, Tokyo Medical and Dental University , Endocrine Research Unit, Mayo Clinic ) 1,2 1 － 264 － 2 of disease-specific induced pluripotent stem cells from patients with Cleidocranial dysplasia OP-23 Generation ○ Akiko Saito , Takashi Nakamura , Shoko Onodera , Hiromi Shino , Akio Ooki , Daigo Hasegawa , Akira Watanebe , （P2-29）Kenjiro Kosaki , Takahiko Shibahara , Kenji Sueishi , Toshifumi Azuma 1 4 5 1 3 1 2 2 3 3 1 (Department of Biochemistry, Tokyo Dental College 1, Department of Orthodontist, Tokyo Dental College 2, Department of Oral and Maxillofacial Surgery, Tokyo Dental College 3, Department of Biochemistry & Integrative Medical Biology, School of Medicine, Keio University 4, Center for Medical Genetics, School of Medicine, Keio University 5) and analysis of a novel GDF6 mutation found in Multiple Synostoses Syndrome OP-24 Identification ○ Satoshi Ohte （P2-43）(Department of Developmental Biology, Harvard School of Dental Medicine , Division of Pathophysiology, Saitama 1,2 1 Medical University Research Center for Genomic Medicine 2) of Galnt3 in Chondrocytes Resulted in Dwarfism Due to the Increase of Mucin-type O-Glycans and OP-25 Overexpression Reduction of Glycosaminoglycans （P2-42）○ Tetsuya Kawane, Takeshi Moriishi, Hisato Komori, Toshihisa Komori (Unit of Basic Medical Sciences, University of Nagasaki) dimensional fine structural Imaging of gap-junction in bone lacunae using FIB-SEM serial imaging method OP-26 Three ○ Ichiro Kawahara , Aki Kameda , Sunao Sadaoka , Kimitoshi Yagami （P2-19）(Department of Oral Health Science , Department of Helth Promotion , Institute of Oral Science , Undergraduate Shool 1,2,3 4 1 2 1 2 3 of Dentistry 4) Poster Presentation of osteoclast differentiation during bone modeling in medaka pharyngeal teeth P1-01 Mechanism ○ Akiko Mantoku , Masahiro Chatani , Kazushi Aono , Keiji Inohaya , Yoshiro Takano , Akira Kudo （OP-16）(Department of Biological Information, Tokyo Institute of Technology , Section of Biostructural Science, Department of 1 1 1 1 2 1 1 Hard Tissue Engineering, Division of Bio-Matrix, Graduate School of Tokyo Medical and Dental University 2) P1-02 Sphingomyelin Synthase 2 in Osteoblasts Promotes Osteoclast Differentiation ○ Yoshihiro Yoshikawa, Takashi Ikeo (Department of Biochemistry, Osaka Dental University) P1-03 Negative Regulation of Osteoclastogenesis by Galectin-9 through down-regulating NFATc1 by inducing Suppressive transcription factor MafB and IRF-8 ○ Yukari Kyumoto 1, Norihisa Uehara 1, Akiko Kukita 2, Toshio Kukita 1 (Department of Molecular Cell Biology and Oral Anatomy, Faculty of Dental Science, Kyushu University 1, Microbiology, Faculty of Medicine, Saga University 2) P1-04 Regulation of osteoclast differentiation by extracellular matrix Laminin-332 through RANK expression ○ Norihisa Uehara 1, Akiko Kukita 2, Yukari Kyumoto 1, Hisataka Yasuda 3, Toshio Kukita 1 (Department of Molecular Cell Biology & Oral Anatomy, Kyushu University 1, Microbiology, Faculty of Medicine, Saga University 2, Oriental Yeast Co., Ltd. 3) P1-05 The dynamin inhibitor dynasore suppresses bone-resorbing activity of osteoclasts through rapid disruption of actin rings of osteoclasts ○ Gnanasagar J . Thirukonda 1, Shunsuke Uehara 2, Teruhito Yamashita 1, Yukio Nakamura 3, Toshihide Mizoguchi 1, Naoyuki Takahashi 1, Kimitoshi Yagami 4, Nobuyuki Udagawa 2, Yasuhiro Kobayashi 1 (Institute for Oral Science, Matsumoto Dental University 1, Department of Biochemistry, Matsumoto Dental University 2, Department of Orthopaedic Surgery, School of Medicine, Shinshu University 3, Department of Oral Implantology, Matsumoto Dental University 4) P1-06 A new osteoclast regulator DCL-1/CD302 and its interaction with CCN2 ○ Eriko Aoyama 1, Takako Hattori 2, Mitsuhiro Hoshijima 1,3, Satoshi Kubota 1,2, Masaharu Takigawa 1 (Assistant Professor Advanced Research Center for Oral and Craniofacial Sciences 1, Department of Biochemistry and Molecular Dentistry2, Department of Orthodontics and Dentofacial Orthopedics 3) farnesoid X receptor negatively regulates osteoclastogenesis via JNK dependent PPARγ signaling pathways P1-07 The ○ Ting Zheng, Mijung Yim （OP-14）(Colleage of Pharmacy, Sookmyung Women's University) P1-08 Autophagy activation via Becn1 is required in RANKL-mediated osteoclast differentiation ○ Atsushi Arai 1,2,3, Sol Kim 1, Terresa Kim 1, Cindy Lee 1, Cun-Yu Wang 1, No-Hee Park 1, Reuben Kim 1 (Division of Oral Biology and Medicine, School of Dentistry, University of California Los Angeles 1, Department of Orthodontics Matsumoto Dental University 2, Institute for Oral Science, Matsumoto Dental University 3) P1-09 Tankyrase regulates osteoclast differentiation via SH3BP2 ○ Shunichi Fujita 1, Tomoyuki Mukai 1, Yasuyoshi Ueki 2, Yoshitaka Morita 1 (Department of Rheumatology, Kawasaki Medical School 1, Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City 2) P1-10 BTB and CNC homology 1（Bach1）nuclear export attenuates osteoclastogenesis and osteoclast activation via inhibition of intracellular ROS signaling ○ Hiroyuki Kanzaki 1,2, Fumiaki Shinohara 3, Masazumi Matsuzawa 1, Kanako Itohiya-Kasuya 1, Yoshiki Nakamura 1 (Department of Orthodontics, School of Dental Medicine, Tsurumi University 1, Tohoku University Hospital, Maxillo-Oral Disorders 2, Tohoku University, Graduate School of Dentistry, Oral Microbiology 3) － 265 － P1-11 Molecular mechanism of stimulation of osteoclast differentiation by antioxidant glutathione ○ Hirofumi Fujita 1, Eriko Aoyama 2, Hideyo Ohuchi 1 (Department of Cytology and Histology, Okayama Uniersity 1, ARCOCS Okayama University Dental school 2) P1-12 IL-15 and RANKL play an synergistically important role in osteoclastogenesis ○ Iichiro Okabe 1, Takeshi Kikuchi 1, Makio Mogi 2, Makoto Aino 1, Akio Mitani 1 (Department of Periodontology, School of Dentistry, Aichi Gakuin University 1, Department of Medicinal Biochemistry, School of Pharmacy, Aichi-Gakuin University 2) P1-13 Inhibitory Effects of Caldecrin on the LPS stimulated osteoclastogenesis ○ Nobuaki Tamura 1, Mineko Tomomura 2, Shoko Kawaguchi 1, Jun Shimada 1, Akito Tomomura 2 (First Division of Oral and Maxillofacial Surgery, Department of Diagnostic & Theraputic Sciences, Meikai University School of Dentistry 1, Division of Biochemistry, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry 2) P1-14 Screening for drugs affecting osteoclast differentiation ○ Juri Nakata 1,2, Yoshito Kakihara 1, Jun Nihara 2, Isao Saito 2, Hiroshi Egusa 3, Makio Saeki 1 (Division of Dental Pharmacology, Niigata University Graduate School of Medical and Dental Sciences 1, Division of Orthodontics, Niigata University Graduate School of Medical and Dental Sciences 2, Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry 3) P1-15 Can combined therapy of teriparatide and low-intensity pulsed ultrasound accelerate fracture healing with Ilizarov external fixator? ○ Koji Nozaka, Yoichi Shimada, Naohisa Miyakoshi, Shin Yamada, Michio Hongo, Yuji Kasukawa, Hidetomo Saito, Hiroaki Kijima, Hiroyuki Tsuchie (Department of Orthopedic Surgery, Akita University Graduate School of Medicine) P1-16 Effect of mechanical strain on autophagy and apoptosis in rat calvarial osteocytic cells ○ Shinichiro Kuroshima 1, Nao Inaba 2, Takashi Sawase 2 (Oral & Maxillofacial Implant Center, Nagasaki University Hospital 1, Department of Applied Prosthodontics, Graduate School of Biomedical Sciences, Nagasaki University2) P1-17 Mechanical stress mediate hedgehog signaling of osteoblast ○ Kenichi Matsumoto 1, Tsuyoshi Shimo 1,2, Naito Kurio 1, Tatsuo Okui 1, Yuuki Kunisada 1, Akira Sasaki 1,2 (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, University of Okayama 1, Department of Oral and Maxillofacial Surgery, Okayama University 2) P1-18 Effects of ultraviolet-B and mechanical stress on Bone ○ Sangun Lee 1, Takao Suzuki 1, Junichi Hashimoto 1, Hiromi Izawa 2 (Department of Physical Therapy, Aomori University of Health and Welfare 1, Department of Nutrition, Aomori University of Health and Welfare 2) P1-19 Effects of different intensities in mechanical loading on structures of tibial cancellous bone in rats ○ Masato Takahashi 1, Shota Kusaka 1, Masafumi Ohsako 2 (Graduate School of Welfare Society Design, Toyo University 1, Toyo University, Faculty of Human Life Design 2) P1-20 Effects of decrease in mechanical loading on structure of cell layers of tibial articular cartilage in rats ○ Shota Kusaka 1, Masato Takahashi 1, Masafumi Oosako 2 (Graduate School of Welfare Society Design, University of Toyo 1, Faculty of Human Life Design, University of Toyo 2) ER stress sensor OASIS is involved in angiogenesis during bone formation in a coordinated manner with HIF1α P1-21 An ○ Min Cui , Soshi Kanemoto , Yuki Yoshimoto , Chisa Shukunami , Kazunori Imaizumi （OP-19）(Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University , Department of Molecular 1 1 2 2 1 1 2 Biology and Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University ) P1-22 Osteoblasts regulate the differentiation of mesenchymal stem cells via gap junctions ○ Yoshikazu Mikami (Department of Pathology, School of Dentistry Nihon University) P1-23 The localization of SUMO proteins and enzymes in the bone tissue of Xenopus laeveis ○ Akira Yukita, Masayuki Takubo (Department of Education（Sciences）, Shizuoka University) P1-24 Role of Profiin-1 in regulation of osteoblastic differentiation ○ Wanting Lin 1,2, Yayoi Izu 2, Youyichi Ezura 2, Keiji Moriyama 1, Masaki Noda 2 (Maxillofacial Orthogmathics, Tokyo Medical and Dental University 1, Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University 2) P1-25 Human iPS cell established from Gorlin symdrome patients and osteoblast differentiation ○ Shoko Onodera 1, Daigo Hasegawa 2, Akiko Saito 1, Manami Ootaka 3, Akira Watanabe 2, Ken Nishimura 4, Akira Katakura 5, Takahiko Shibahara 2, Makoto Nakanishi 3, Toshifumi Azuma 1 (Department of Biochemistry 1, Department of Oral and Maxillo-Facial Surgery, Tokyo Dental College 2, Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology 3, Laboratory of Gene Regulation 4, Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Tokyo Dental College 5) － 266 － P1-26 Interleukin-1beta-induced autophagy-related gene 5 regulates the proliferation of mouse embryonic stem cell-derived odontoblastic cells ○ Nobuaki Ozeki 1, Makio Mogi 2, Ayami Morita 2, Kazuhiko Nakata 1 (Department of Endodontics, School of Dentistry, Aichi Gakuin University 1, Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University 2) P1-27 Inorganic polyphosphate induces matrix metalloproteinase-3 mediated proliferation of odontoblast-like cells derived from mouse induced pluripotent stem cells ○ Makio Mogi 1, Nobuaki Ozeki 2, Ayami Morita 1, Kazuhiko Nakata 2 (Department of Medicinal Biochemistry, School of Pharmacy, Aichi-Gakuin University 1, Department of Endodontics, School of Dentistry, Aichi-Gakuin University 2) P1-28 Salmon new scaffold promotes bone deposition in rat calvarial defects via NaPi transporters ○ Yuri Katsumata 1,2, Hiroshi Kajiya 1,3, Jum Ohno 1,4, Koji Okabe 3, Tetsuro Ikebe 2 (Center for Regenerative Medicine, Fukuoka Dental College 1, Department of Oral and Maxillofacial Surgery, Fukuoka Dental College 2, Department of Physiological Science and Molecular Biology, Fukuoka Dental College 3, Department of Morphological Biology, Fukuoka Dental College 4) P1-29 Tryptophan enhances the stem cell phenotype and osteoblastic differentiation of bone marrow-derived mesenchymal stromal cells in vitro and in vivo ○ Hai Thanh Pham, Mitsuaki Ono, Emilio Satoshi Hara, Yasutaka Oida, Ha Thi Nguyen, Kentaro Akiyama, Takuo Kuboki (Dentistry and Pharmaceutical Sciences, Oral Rehabilitation and Regenerative Medicine, Okayama University, Graduate School of Medicine) P1-30 Evaluation of bone formation ability with the collagen coat b-TCP having ang iogenesis by geometry structure ○ Kimitoshi Yagami 1, Sunao Sadaoka 1, Yoshinori Kuboki 4, Jun Onodera 3, Michio Matsunaga 3, Mariko Kimura 2, Masahiko Suzuki 2 (Department of Oral Health Promotion, Graduate School of Oral Medicine, Matsumoto Dental University 1, Pilot Corporation 2, Koken Co., Ltd 3, Hokkaido University 4) P1-31 The presence and origin of CCN family proteins in Megakaryocyte and Platelets ○ Chikako Hara 1,3, Satoshi Kubota 1,3, Eriko Aoyama 3, Hiroshi Kamioka 2, Masaharu Takigawa 1,3 (Department of Biochemistry & Molecular Dentistry Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences1, Department of Orthodontics Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2, Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School 3) P1-32 Epigenetic control of the osteoblast differentiation through a DNA methylation ○ Masahiko Okubo 1,2, Masahito Matsumoto 2, Izumi Sugawara 2, Yosuke Mizuno 2, Naoki Hayashi 1, Yuichiro Enoki 1, Tsuyoshi Sato 1, Tatsuo Suda 2, Yasushi Okazaki 2, Tetsuya Yoda 1 (Department of Oral and Maxillofacial Surgery Saitama Medical University 1, Division of Functional Genomics & Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University 2) P1-33 The bone-bonding ability of the new Ti-Nb-Sn Alloy with low Young's Modulus via Anodic Oxidation and Hot Water Treatment ○ Hidetatsu Tanaka 1, Yu Mori 1, Atsushi Noro 3, Atsushi Kogure 1, Norikazu Yamada 4, Naoya Masahashi 2, Shuji Hanada 2, Eiji Itoi 1 (Tohoku University Graduate School of Medicine 1, Institute for Materials Research, Tohoku University 2, Yamagata City Hospital Saiseikan 3, Sendai Red Cross Hospital 4) factor Nfil3/E4BP4 regulates cellular proliferation in response to α1B-adrenergic receptor signaling in P1-34 Transcriptional osteoblasts （OP-20）○ Takao Hirai, Kenjiro Tanaka, Akifumi Togari (Department of Pharmacology, School of Dentistry, Aichi-Gakuin University) role of Wnt signal modulator gene, sFRP4, in bone formation/metabolism P1-35 The ○ Ryuma Haraguchi 1, Riko Kitazawa 1,2, Yuuki Imai 3, Sohei Kitazawa 1 （OP-21）(Dept. Mol. Pathol., Ehime Univ.1, Dept. Diagn. Pathol., Ehime Univ. Hosp.2, PROS, Ehime Univ.3) P1-36 Tmem161a gene knock out mice,using by Exchangable gene trap method exhibit an obvious bone mass increase ○ Syuji Kurogi, Tomohisa Sekimoto, Tarou Funamoto, Tomomi Ohta, Shihoko Nakamura, Takuya Nagai, Etsuo Chosa (Department of Orthopaedic Surgery, University of Miyazaki.) P1-37 Analysis of lamin B receptor in bone metabolism using exchangeable gene trap mutagenesis ○ Taro Funamoto, Tomohisa Sekimoto, Syuji Kurogi, Shihoko Nakamura, Tomomi Ota, Etsuo Chosa (Department of Orthopaedic Surgery, University of Miyazaki) P1-38 IL-6 induces vascular calcification of vascular smooth muscle cells through STAT3 dependent pathway ○ Akira Kurozumi, Kazuhisa Nakano, Kaoru Yamagata, Yousuke Okada, Shingo Nakayamada, Yoshiya Tanaka (First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health) P1-39 Activated collagen peptide“Pro-Hyp”promotes ERK phosphorylation and osteoblastic differentiation in MC3T3-E1 ○ Yoshifumi Kimira 1, Aya Kataoka 2, Hiroshi Mano 1 (Josai University 1, Nitta Gelatin Inc 2) － 267 － P1-40 Under osteogenic culture conditions osteoblast-like MC3T3E-1 cells express Poldip2 ○ Sakie Katsumura 1, Yoichi Ezura 2, Yayoi Izu 2, Masaki Noda 2 (Maxilo Facial Surgery 1, Molecular Pharmacology 2) PEG10 inhibits enhanced invasive behavior of chondrosarcoma cells P1-41 BMP-induced ○ Naohiro Shinohara , Shingo Maeda , Yuhei Yahiro , Katsuyuki Imamura , Masahiro Yokouchi , Ichiro Kawamura （OP-03）Yasuhiro Ishidou , Setsurou Komiya 1,2 1 1 1,2 2 2 1,2 1,2 , (Department of Medical Joint Materials, Kagoshima University 1, Department of Orthopaedic Surgery, Kagoshima University 2) P1-42 BMD and TBS use in adult patients suffering from Polio ○ Renaud Winzenrieth 1, D Grados Canovas 3, Luis Del Rio 2, E Bonel 2, M Garcia 2, Silvana Di Gregorio 2 (R&D Department, Med-Imaps, Merignac, France 1, Cetir Grup Mèdic, Barcelona, Spain 2, Reumatologia, Hospital Sant Rafael, Barcelona, Spain 3) P1-43 A case of malignant pheochromocytoma with multiple bone metastasis ○ Yasato Komatsu 1, Yuji Hataya 1, Tohru Yoshida 2, Takehiko Segawa 2 (Department of Endocrinology, Kyoto City Hospital 1, Department of Urology, Kyoto City Hospital 2) factor for fracture in patients with rheumatoid arthritis is not the disease itself but the use of glucocorticoid –the P1-44 A4thriskyear results of the TOMORROW study（OP-06）○ Yuko Sugioka , Kentaro Inui , Kenji Mamoto , Tadashi Okano , Masahiro Tada , Tatsuya Koike 1 3 3 3 3 1,2 (Center for Senile Degenerative Disorders（CSDD）, Osaka City University Medical School , Search Institute for Bone and Arthritis Disease（SINBAD）2, Orthopedic Surgery, Osaka City University Medical School 3) 1 P1-45 Risk of low bone mineral density in patients with rheumatoid arthritis treated with biological disease-modifying antirheumatic drugs ○ Kengo Takahashi 1, Takao Setoguchi 1,3, Yoshiya Arishima 2, Yasuhiro Ishidou 1,4, Sanae Shigemizu 2, Noriko Aoki 2, Masaki Akimoto 2, Hideo Otsubo 2, Takemasa Matsuda 2, Masahiro Yokouchi 1, Satoshi Nagano 1, Nobuhiko Sunahara 2, Setsuro Komiya 1,3,4 (Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University 1, , Graduate Kagoshima Red Cross Hospiral 2, The Near Future Locomotor Organ Medicine Creation Course（Kusunoki Kai） School of Medical and Dental Sciences, Kagoshima University 3, Department of Medical Joint Materials, Graduate School 4 of Medical and Dental Sciences, Kagoshima University ) inhibits human osteoclastogenesis P1-46 IL-35 ○ Toru Yago, Yuki Nanke, Manabu Kawamoto, Shigeru Kotake （OP-07）(Institute of Rheumatology, Tokyo Women's Medical University) Functions of CCN3 on Articular Cartilage P1-47 New ○ Danilo Janune , Tarek Abd El Kader , Eriko Aoyama , Takashi Nishida , Hany Khattab , Satoshi Kubota （OP-05）Masaharu Takigawa 1 1 1 2 1 1 1,2 , (Advanced Research Center for Oral and Craniofacial Sciences, Okayama University 1, Biochemistry and Molecular Dentistry, Okayama University 2) P1-48 Analysis of bone in TCTA knockout mice: a preliminary study ○ Shigeru Kotake 1, Toru Yago 1, Manabu Kawamoto 2, Yuki Nanke 1 (Institute of Rheumatology, Tokyo Women's Medical University 1, Tokyo Women's Medical University 2) therapy with bisphosphonate and eldecalcitol increased calcification of trabecular bone in ovariectomized P1-49 Combination rats （OP-10）○ Hiromi Kimura-Suda , Teppei Ito , Hirotaka Wagatsuma , Tetsuo Yano , Daisuke Inoue 1 1 2 2 3 1 (Chitose Institute of Science and Technology , Ajinomoto Pharmaceuticals Co., Ltd. 2, Teikyo University School of Medicine 3) P1-50 Examination of teriparatide for pain improvement in a mouse model of osteoporosis ○ Sho Kato, Hiroki Wakabayashi, Taro Nakagawa, Yohei Naito, Akihiro Sudo (Department of Orthopaedic Surgery, Mie University Graduate School of Medicine) P1-51 Risk factor of the Non-Responder for the combination therapy with Bisphosphonates and Active Vitamin D Analog for Osteoporosis ○ Kinoshita Mayuko, Muneaki Ishijima, Yuko Sakamoto, Makoto Yamanaka, Hidetoshi Nojiri, Haruka Kaneko, Ryo Sadatsuki, Shinnosuke Hada, Kazuo Kaneko (Dept. of Orthopaedics Juntendo University School of Medicine) P1-52 The efficacy and safty of co-administration of ibandronate and eldecalcitol for primary osteoporosis ○ Mizue Tanaka 1, Shuji Shimamoto 2, Yoshiharu Kato 2 (Kawakita Medical Foundation Kawakita General Hospital 1, Tokyo Women's Medical University 2) of bone turnover markers and bone mineral density using daily teriparatide with or without bisphosphonate P1-53 Changes pre-treatment （OP-13）○ Yukio Nakamura , Mikio Kamimura , Keijiro Mukaiyama , Shota Ikegami , Shigeharu Uchiyama , Hiroyuki Kato 1 2 3 1 1 1 1 2 (Department of Orthopaedic Surgery, Shinshu University School of Medicine , Kamimura Clinic , Department of Orthopaedic Surgery, Azumi General Hospital 3) － 268 － P1-54 The effect of osteoporosis drug on trabecular microarchitecture -Weekly Teriparatide vs. Bisphosphonate○ Kenichiro Matsuzaki 1,2, Keisuke Horiuchi 2, Hironori Kaneko 3, Kensuke Mio 1, Masaaki Takahashi 4, Morio Matsumoto 2, Koichi Nemoto 1 (Department of Orthopedic Surgery, National Defense Medical College 1, Dept. of Orthopedic Surgery, Keio Univ. 2, Dept. of Orthopedic Surgery, Kitasato Institute Hospital 3, Dept. of Orthopedic Surgery, National Tokyo Medical Center 4) P1-55 Strength index of vertebra calculated by fine element method does not reflect the presence of vertebral fractures in patients with type 2 diabetes mellitus ○ Nobuaki Kiyohara, Masahiro Yamamoto, Tositugu Sugimoto (Shimane University Faculty of Medicine) P1-56 Association between basal metabolism and bone metabolism in postmenopausal women with type 2 diabetes: 6months follow up with supplementation of vitamin D ○ Makiko Ogata, Risa Ide, Miho Takizawa, Naoko Iwasaki, Yasuko Uchigata (Diabetes Center,Tokyo Women's Medical University) P1-57 Hyperglycaemia promotes Schwann cell de-differentiation and de-myelination via sorbitol accumulation and Igf1 downregulation ○ Hao Wu, Morio Matsumoto, Masaya Nakamura, Takeshi Miyamoto (Department of Orthopedic, Keio University) P1-58 Osteo-Vascular –Lipo Interactions in type 2 diabetes mellitus ○ Hiroko Mori, Yosuke Okada, Maiko Hajime, Kenichi Tanaka, Yoshiya Tanaka (First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health) P1-59 Effects of eldecalcitol on bone metabolism in postmenopausal women with type 2 diabetes mellitus ○ Kenichi Tanaka, Yosuke Okada, Hiroko Mori, Maiko Hajime, Yoshiya Tanaka (First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health) P1-60 The survey of the treatment strategy for osteoporosis using FRAX in type 2 diabetes ○ Maiko Hajime, Yosuke Okada, Hiroko Mori, Kenichi Tanaka, Yoshiya Tanaka (First Department of Internal Medicine, University of Occupational and Environmental Health) P2-01 Case report: change of bone biomarker after resection of FGF-23 produced tumor ○ Yuji Makino 1, Hidetoshi Nojiri 1, Masaru Tsutiya 1, Mamiko Sawa 1, Kazuo Kaneko 2, Yoshiyuki Iwase 1 (Department of Orthopedics, Juntendo Tokyo Koto Geriatric Medical Center 1, Department of Orthopedics, Juntendo University 2) P2-02 Withdrawn of bone and mineral metabolism in chronic kidney disease using parathyroid gland-specific FGFR conditional P2-03 Analysis KO mice （OP-02）○ Kazuki Kawakami , Ai Takeshita , Masayasu Miyajima , Ikuji Hatamura , Kazushige Sakaguchi 1 1 2 3 1 (Department of Molecular Cell Biology and Molecular Medicine Institute of Advanced Medicine Wakayama Medical University1, Laboratory Animal Center Wakayama Medical University 2, Kansai University of Health Sciences 3) P2-04 Effects of deitary phosphate on the progression of iron-deficiency anemia and iron metabolism in rats ○ Mari Nakao 1, Hironori Yamamoto 2, Shiori Fukuda 1, Yutaka Taketani 1, Eiji Takeda 1 (Department of Clinical Nutrition and Food Management, Institute of Health Biosciences, University of Tokushima 1, Faculty of Human Life, Jin-ai University 2) P2-05 Seasonality in bone mineralization of auditory ossicles and long bones in primate（Macaca fuscata） ○ Makoto Morikawa 1, Porrawee Pomchote 2, Tadashi Sankai 3, Yuzuru Hamada 2, Koichi Matsuo 1 (Keio University School of Medicine 1, Primate Research Institute, Kyoto University 2, Tsukuba Primate Research Center, National Institute of Biomedical Innovation 3) P2-06 Direct analysis of biomolecules in bone by using Imaging mass spectrometry ○ Tomoko Minamizaki, Hirotaka Yoshioka, Yuichiro Takei, Yuji Yoshiko (Department of Calcified Tissue Biology, Hiroshima University Institute of Biomedical and Health Sciences) P2-07 The expression of LGR4 receptor is induced by BMP2 in osteoblast-like cell MC3T3-E1 ○ Chantida Pawaputanon Na Mahasarakham 1,2, Yoichi Ezura 1, Makiri Kawasaki 1, Shuichi Moriya 1, Takayuki Yamada 1, Yayoi Izu 1, Katsuhiko Nishimori 3, Yuichi Izumi 2, Masaki Noda 1 (Department of Molecular Pharmacology, Tokyo Medical and Dental University 1, Department of Periodontology, Tokyo Medical and Dental University 2, Graduate School of Agricultural Science, Tohoku University 3) P2-08 Calcitonin of platypus which is a primitive mammal has strong bioactivity ○ Teruhito Yamashita 1, Hiroyo Yamauchi 1,3, Shunsuke Uehara 2, Naoyuki Takahashi 1, Nobuyuki Udagawa 2 (Institute for Oral Science, Matsumoto Dental University 1, Department of Oral Biochemistry, Matsumoto Dental University 2, Japan Osteoporosis Foundation 3) P2-09 Clinical results of osteoporosis treatment by denosmab for 12 months ○ Rui Niimi 1, Toshibumi Kono 1, Toshihiko Kono 1, Akihiro Sudo 2 (Department of Orthopaedic Surgery, Tomidahama Hospital 1, Department of Orthopaedic Surgery, Mie University Graduate School of Medicine 2) － 269 － oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction P2-10 Lectin-like in mice, despite promoting osteoclastogenesis in the steady state （OP-15）○ Junta Ito, Chiyomi Hayashida, Yoko Ohyama, Takuya Sato, Yoshiyuki Hakeda (Division of Oral Anatomy, Meikai University School of Dentistry) P2-11 HIV-1 replicates in human osteoclasts and enhances their differentiation in vitro ○ Jin Gohda (Research Center for Asian Infectious Diseases, The Institute of Medical Science, the University of Tokyo) P2-12 Attenuation of antiresorptive action in withdrawal of minodronic acid for three months after treatment for twelve months in ovariectomized rats ○ Makoto Tanaka 1, Hiroshi Mori 2 (Reserch Promotion, Ono Pharmaceutical Co., Ltd. 1, Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd. 2) P2-13 Effect of eldecalcitol on inflammatory markers in patients with rheumatoid arthritis ○ Hayato Kinoshita 1,2,3, Naohisa Miyakoshi 1, Yuji Kasukawa 1, Yoichi Shimada 1 (Department of Orthopedic Surgery, Akita University Graduate School of Medicine 1, A-BONE 2, AORA 3) P2-14 Osteoclastogenesis without osteoblasts in the subcutaneous implantation system using ceramic granules ○ Kota Morishita 1, Yasuaki Shibata 2, Eri Tatsukawa 2, Masanobu Kamitakahara 3, Gazi Jased Ahmed 1, Masahiro Umeda 1, Tohru Ikeda 2 (Department of Clinical Oral Oncology, Nagasaki Unversity Graduate School of Biomedical Sciences1, Department of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences 2, Graduate School of Environment Studies, Tohoku Univeristy 3) P2-15 Activation of AMP-activated Protein Kinase Protects Against Homocysteine-Induced Apoptosis of Osteocytic MLO-Y4 Cells ○ Ayumu Takeno, Ippei Kanazawa, Ken-icihro Tanaka, Masakazu Notsu, Maki Yokomoto, Toru Yamaguchi, Toshitsugu Sugimoto (Internal Medicine 1, Shimane University Faculty of Medicine) P2-16 Oxysterol induces apoptosis through reactive oxygen species （ROS）in MC3T3-E1 cells ○ Yuta Sato, Noriko Ishihara, Shou Tanaka, Rena Watanabe, Yasuhiro Watanabe, Haruki Imamura, Takashi Yamaguchi, Noriko Ban, Hidetoshi Kawana, Ayako Nagumo, Masahiro Ohira, Atsuhito Saiki, Ichiro Tatsuno (Center for Diabetes, Metabolism and Endocrinology, Toho University Sakura Medical Center) P2-17 Examination of the β2-adrenergic receptor expression levels in osteocytes in vitro ○ Koji Mineta, Yoichi Ezura, Yayoi Izu, Masaki Noda (Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical & Dental University) P2-18 Imaging analyses of the osteocyte lacunar-canalicular network after alendronate administration ○ Kanako Tsuboi, Hiromi Hongo, Tomoka Hasegawa, Tomomaya Yamamoto (Depaertment of Hard Tissue, University of Hokkaido) dimensional fine structural Imaging of gap-junction in bone lacunae using FIB-SEM serial imaging method P2-19 Three ○ Ichiro Kawahara , Aki Kameda , Sunao Sadaoka , Kimitoshi Yagami （OP-26）(Department of Oral Health Science , Department of Helth Promotion , Institute of Oral Science , Undergraduate Shool 1,2,3 4 1 1 2 2 3 4 of Dentistry ) P2-20 Ultrastructural assessment of the osteocytic networks by using recent electron microscopic techniques ○ Tomoka Hasegawa, Tomomaya Yamamoto, Hiromi Hongo, Kanako Tuboi, Tsuneyuki Yamamoto, Norio Amizuka (Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University) of TRAF6 in differentiation and maturation of osteoclasts P2-21 Role ○ Yo Yumiketa, Yuu Taguchi, Jun-ichiro Inoue （OP-18）(The University of Tokyo, The Institutes of Medical Science) function of internalized RANK in osteoclastogenesis P2-22 The ○ Yuu Taguchi, Jun-ichiro Inoue （OP-17）(The University of Tokyo, The Institute of Medical Science) P2-23 Analysis of osteoclast-specific TAK1 kinase-deficient mice ○ Eriko Sumiya, Hiroshi Takayanagi (Department of Immunology, Graduate School of Medicine, The University of Tokyo) P2-24 Gene expression profiling using DNA microarray analysis osteoclast differentiation inhibited by sulforaphane and sulforaphene, sulfur-containing compounds ○ Hirofumi Inoue, Mariko Uehara (Department of Nutritional Science and Food Safety) P2-25 Stimulatory effects of antimicrobial peptide cathelicidin on dentin reparation ○ Kanji Horibe, Akihiro Hosoya, Toru Hiraga, Hiroaki Nakamura (Department of Oral histology, Matsumoto Dental University) － 270 － P2-26 The effects of a comprehensive mixture of tobacco smoke components related to experimental tooth movement and osteoclastogenesis in the rat ○ Maya Nagaie 1, Yoshitomo Honda 2, Aki Nishiura 1, Shin-ichi Fujiwara 3, Naoyuki Matsumoto 1 (Department of Orthodontics, Graduate School of Dentistry, Osaka Dental University 1, Institute of Dental Research, Osaka Dental University 2, Department of Chemistry, Osaka Dental University 3) GTPase Cdc42 is crucial for palatal development P2-27 Small ○ Mutsuko Oshima , Atsushi Yamada , Dai Suzuki , Koutaro Maki , Ryutaro Kamijo （OP-04）(Department of Biochemistry, University of Showa , Department of Orthodontics, University of Showa ) 1,2 1 1 2 1 1 P2-28 2 The signal pathway of toll-like receptor 2 due to LTA（lipoteichoic acid）leads to inflammatory bone resorption ○ Chiho Matsumoto, Tsukasa Tominari, Michiko Hirata, Chisato Miyaura, Masaki Inada (Department of Biotechnology, Graduate School of Engineering, Tokyo University of Agriculture and Technology) of disease-specific induced pluripotent stem cells from patients with Cleidocranial dysplasia P2-29 Generation ○ Akiko Saito , Takashi Nakamura , Shoko Onodera , Hiromi Shino , Akio Ooki , Daigo Hasegawa , Akira Watanebe , （OP-23）Kenjiro Kosaki , Takahiko Shibahara , Kenji Sueishi , Toshifumi Azuma 1 5 4 1 3 2 1 2 3 3 1 (Department of Biochemistry, Tokyo Dental College 1, Department of Orthodontist, Tokyo Dental College 2, Department of Oral and Maxillofacial Surgery, Tokyo Dental College 3, Department of Biochemistry & Integrative Medical Biology, School of Medicine, Keio University 4, Center for Medical Genetics, School of Medicine, Keio University 5) P2-30 Characteristic synovium derived stromal cell genes, including Comp, Asporin, Prelp and Prg4 are expressed more in embryonic menisci and epiphyseal cartilage rather than in synovium ○ Yoichi Ezura 1, Yayoi Izu 1, Takeshi Muneta 3, Ichiro Sekiya 2, Masaki Noda 1 (Department of Molecular Pharmacology, Tokyo Medical and Dental University 1, Section of Applied Regenerative Medicine, Tokyo Medical and Dental University 2, Department of Joint Surgety and Sports Medicine, Tokyo Medical and Dental University 3) P2-31 Change in localization of mesenchymal stem cells during ectopic ossification of spinal ligament ○ Ken-Ichi Furukawa 1, Shunfu Chin 2, Toshihiro Tanaka 2, Kanichiro Wada 2 (Department of Pharmacology, Hirosaki University Graduate School of Medicine 1, Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine 2) P2-32 The role of estrogen on the function of female skeletal muscle ○ Yuriko Kitajima, Yusuke Ono (Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University) P2-33 Study on intramuscular vitamin D receptor number and muscle quality changes associated with menopause ○ Kazuhide Inage, Kazuki Fujimoto, Jun Sato, Kazuyo Yamauchi, Sumihisa Orita, Miyako Suzuki, Go Kubota, Takeshi Sainoh, Yasuhiro Shiga, Koki Abe, Hirohito Kanamoto, Seiji Ohtori (Dept. of Orthopaedic Surgery, Graduate School of Medicine, Chiba University) P2-34 Therapeutic potential of Myostatin（GDF8）on immobilized muscle atrophy ○ Toshimi Tando, Masaya Nakamura, Morio Matsumoto, Takeshi Miyamoto (Department of Orthopedic Surgery, Keio University School of Medicine) P2-35 Acidification of muscle associated with menopause may affect myogenic low back pain ○ Kazuki Fujimoto, Kazuhide Inage, Jun Sato, Kazuyo Yamauchi, Sumihisa Orita, Miyako Suzuki, Gou Kubota, Takeshi Sainoh, Yasuhiro Shiga, Koki Abe, Hirohito Kanamoto, Seiji Ohtori (Department of Orthopaedic Surgery, Chiba University) P2-36 Short-foot-loading relieves the atrophy of rat's anti-gravity muscle and improves muscle proteostasis: from dynamics of a key moleculelar chaperone αB-crystallin ○ Aya Atomi 1, Eri Fujita 1, Tomoaki Atomi 2, Miho Shimizu 1, Yoriko Atomi 1 (Dept. of Material Health Sci., Fac. & Grad. Sch. of Eng., Tokyo Univ. of Agri. & Tech. 1, Dept. of Physical Therapy, Fac. of Med Sci., Teikyo Univ of Sci. 2) P2-37 CCN4 up-regulates the chondrogenesis by controlling the function of TGF-β3 ○ Yuya Yoshioka 1, Mitsuaki Ono 1, Azusa Maeda 1,2, Emilio Satoshi Hara 1, Marian Young 2, Takuo Kuboki 1 (Okayama University 1, NIDCR/NIH 2) P2-38 Regulation of amino acid metabolism in chondrocytes by CCN2 ○ Yurika Murase 1,2, Takako Hattori 1, Eriko Aoyama 3, Takashi Nishida 1, Aya Maeda 1, Harumi Kawaki 1, Akira Sasaki 2, Masaharu Takigawa 3, Satoshi Kubota 1 (Dept. Biochem. and Mol. Dent., Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci. 1, Dept. Oral and Maxillofacial Surgery., Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci. 2, Adv. Res. Ctr. Oral Craniofac. Sci., Okayama Univ. Dent. Sch. 3) P2-39 Odz3 is a novel factor regulating chondrogenesis ○ Ikuko Takano, Nobuo Takeshita, Daisuke Seki, Toshihito Oyanagi, Teruko Takano-Yamamoto (Tohoku University) P2-40 Endogenously produced reactive sulfur species enhanced proliferation of mouse chondrocytes and elongation of bones ○ Marie Hoshino 1,2, Kotaro Kaneko 1,3, Yoichi Miyamoto 1, Daichi Chikazu 3, Kazuyoshi Baba 2, Ryutaro Kamijo 1 (Department of Biochemistry, Showa University School of Dentistry 1, Department of Prosthodontics, Showa University School of Dentistry 2, Department of Oral and Maxillofacial Surgery, Tokyo Medical University 3) － 271 － P2-41 The effectiveness of C-type natriuretic peptide for midfacial hypoplasia occurring in achondroplasia model mouse ○ Shigeki Yamanaka 1, Kazumasa Nakao 1, Akihiro Yasoda 2, Noriaki Koyama 1, Yu Isobe 1, Toshihito Fujii 2, Eri Kondo 2, Masako Miura 2, Kazuhisa Bessho 1 (Department of Oral and Maxillofacial Surgery, University of Kyoto 1, Department of Diabetes and Clinical Nutrition, University of Kyoto 2) of Galnt3 in Chondrocytes Resulted in Dwarfism Due to the Increase of Mucin-type O-Glycans and P2-42 Overexpression Reduction of Glycosaminoglycans （OP-25）○ Tetsuya Kawane, Takeshi Moriishi, Hisato Komori, Toshihisa Komori (Unit of Basic Medical Sciences, University of Nagasaki) and analysis of a novel GDF6 mutation found in Multiple Synostoses Syndrome P2-43 Identification ○ Satoshi Ohte 1,2 （OP-24）(Department of Developmental Biology, Harvard School of Dental Medicine 1, Division of Pathophysiology, Saitama Medical University Research Center for Genomic Medicine 2) and Characterization of Human Osteoblasts From Needle Biopsies Without In Vitro Culture P2-44 Isolation ○ Koji Fujita （OP-22）(Department of Orthopaedic Surgery, Tokyo Medical and Dental University , Endocrine Research Unit, Mayo Clinic ) 1,2 1 2 P2-45 Collagen fiber orientation in metaphysis of rat femoral cortical bone is not necessarily coincident with hydroxyapatite orientation in modeling ○ Teppei Ito, Yuya Kanehira, Kyosuke Kanazawa, Hiromi Kimura-Suda (Chitose Institute of Science and Technology) P2-46 Interaction between titanium and collagen: Further findings after the discovery of implant proteins ○ Yoshinori Kuboki 1, Saori Kunii 2, Kouichi Morimoto 2, Toshitake Furusawa 3, Kimitoshi Yagami 4 (Graduate School of Earth and Environmental Science, Hokaido University 1, School of Science and Engineering, Kinki University 2, School of Engineering, Yamagata University 3, Department of Oral Implantology, Matsumoto Dental University 4) P2-47 Early tissue response to synthetic octacalcium phosphate in rat tibia ○ Bunichi Hirayama 1,2, Takahisa Anada 2, Naohisa Miyatake 3, Kaori Tsuchiya 2, Masanori Nakamura 4, Tetsu Takahashi 1, Osamu Suzuki 2 (Division of Oral and Maxillofacial Surgery, Tohoku University Graduate School of Dentistry 1, Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry 2, Honma Memorial Tohoku Orthopaedic Hospital3, Department of Oral Anatomy, Showa University School of Dentistry 4) P2-48 Effect of W9 peptide on alveolar bone resorption in OPG-deficient mice ○ Yuki Ozaki 1, Masanori Koide 2, Yuriko Furuya 3, Tadashi Ninomiya 2, Hisataka Yasuda 4, Midori Nakamura 2,5, Nobuo Yoshinari 6, Naoyuki Takahashi 2, Nobuyuki Udagawa 2,5 (Division of Oral Health Promotion, Graduate School of Oral Medicine, Matsumoto Dental University 1, Division of Hard Tissue Research, Institute for Oral Science, Matsumoto Dental University 2, Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd. 3, Planning & Development, Bioindustry Division, Oriental Yeast Co., Ltd 4, Department of Biochemistry, Matsumoto Dental University 5, Department of Periodontology, Matsumoto Dental University 6) P2-49 Freeze-dried human Platelet-Rich Plasma retains activation and growth factor expression after eight-week preservation: Quantitative evidence ○ Yasuhiro Shiga, Gou Kubota, Sumihisa Orita, Kazuyo Yamauchi, Miyako Suzuki, Jyun Sato, Kazuki Fujimoto, Kouki Abe, Hiroto Kanamoto, Seiji Ohtori (Department of Orthopedic Surgery, Graduate School of Medicine, Chiba Univercity) P2-50 The reasons for lost follow-up during daily teriparatide treatment ○ Rui Niimi 1, Toshibumi Kono 1, Toshihiko Kono 1, Akihiro Sudo 2 (Department of Orthopaedic Surgery, Tomidahama Hospital 1, Department of Orthopaedic Surgery, Mie University Graduate School of Medicine 2) P2-51 The effects of the denosumab treatment on the bisphosphonate non-responding osteoporotic patients ○ Yukio Nakamura 1, Mikio Kamimura 2, Keijiro Mukaiyama 3, Shota Ikegami 1, Shigeharu Uchiyama 1, Hiroyuki Kato 1 (Department of Orthopaedic Surgery, Shinshu University School of Medicine 1, Kamimura Clinic 2, Department of Orthopaedic Surgery, Azumi General Hospital 3) P2-52 Anti-RANKL treatment improves quality of life of patients with osteoporosis ○ Toshihisa Maeda 1, Shinya Hayashi 1, Yasushi Miura 1,2, Yoshitada Sakai 1,3, Ryosuke Kuroda 1, Masahiro Kurosaka 1 (Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine 1, Division of Orthopedic Science, Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences 2, Division of Rehabilitaion Medicine, Kobe University Graduate School of Medicine 3) P2-53 A study concerning the changes of bone mineral density and metabolic marker after giving denosumab to patients suffering from osteoporosis ○ Reo Goto (Department of Orthopaedics, Abashiri Kousei General Hospital) P2-54 Clinical outcomes in patients with osteoporosis receiving teriparatide treatment （follow-up report） ○ Atsushi Kawaguchi (Department of Orthopedics, Hashima City Hospital) － 272 － P2-55 The effect on the calcaneal bone mass in therapy with the teriparatide : examination by the double energy X-ray absorption assay（DXA） ○ Tomohiro Horikawa (Department of Orthopaedic Surgery, Omutatenryo-hp) P2-56 Changes of bone metabolic markers during treatment with bisphosphonates more than three years ○ Yuji Kasukawa 1,3, Naohisa Miyakoshi 1,3, Michio Hongo 1,3, Koji Nozaka 1,3, Yoshinori Ishikawa 1,3, Daisuke Kudo 1,3, Toshihito Ebina 2, Hiroshi Aonuma 2, Kimio Saito 2, Yoichi Shimada 1,3 (Akita University Graduate School of Medicine 1, Department of Orthopedic Surgery, Kakunodate General Hospital 2, Akita Bone and Osteoporosis Network 3) P2-57 Cooperative effects of soybean isoflavone and kiwifruit on bone metabolism in menopausal women ○ Yoshiko Ishimi 1, Yuko Tousen 1, Marlena Kruger 2 (National Institute of Health and Nutrition 1, Massey University 2) P2-58 Consideration about the persistency rate,the bone metabolism marker, the bone density and the calcium level from the starting time to 1 year ,about an osteoporosis curative at this hospital ○ Makoto Toyota (Orthopedic Surgery Department, Toyama Teishin Hospital) P2-59 Consideration of the bone density of the distal radius, the lumber spine and the femoral neck in a general hospital ○ Ippei Futami 1,2, Muneaki Ishijima 2, Haruka Kaneko 2, Wataru Manabe 1, Rui Katoh 1, Souichi Uta 1 (Saisei Hospital 1, Department of Orthopaedics, Juntendo University School of Medicine 2) P2-60 Relation between Height loss and QOL in osteoporotic patients ○ Kousei Yoh 1, Kiyosi Tanaka 2, Momoyo Seki 2 (Department of Health Science, University of Aino 1, Kyoto Women's University 2) Between Serum Ferritin and Hemoglobin Levels and Bone Health in Korean Adolescent P2-61 Association ○ Kim Do Hoon , Jung Dong-Wook , Han Kyung-Do , Park Yong-Gyu , Ju Sang-Yhun , Roh Yong-Kyun , Choi Jun-Seok , （OP-11）Lee Jong-Eun , Sang Jung-Eun , Nam Hyo-Yun , Nam Ga-Eun , Yoon Yeo-Joon 1 1 1 2 1 1 2 1 3 4 1 1 (Department of Family Medicine, Korea University, College of Medicine 1, Department of Biostatistics, Catholic University, College of Medicine 2, Department of Family Medicine, Catholic University, College of Medicine 3, Department of Family Medicine, Hallym University, College of Medicine 4) Interim report of Drug Use Investigation of Bazedoxifene （Viviant Tablet） P2-62 The ○ Miki Tanigawa , Eriko Uchibori , Etsuya Bando , Yutaka Endo , Luis A Yamamoto （OP-08）(Pfizer Japan Inc. PMS Planning & Operation Group , Pfizer Japan Inc. PMS Date Integration & Operation Group , Pfizer Ⓡ 1 2 3 4 5 1 2 Japan Inc. Data Analysis Reporting Group 3, Pfizer Japan Inc. Clinical Statistics Group 4, Pfizer Japan Inc. GIP Medical Affairs 5) P2-63 Withdrawn a specific bone pattern exist in patient suffering from Cushing's disease? P2-64 Does ○ Renaud Winzenrieth , Amandine Boisson , Antoine Tabarin , Thierry Schaeverbeke , Nadia Mehsen-Cetre （OP-12）(Rheumatology Department, CHU Pellegrin, Bordeaux, France , R&D Department, Med-Imaps, Merignac, France , 2 1 3 1 1 1 2 3 Endocrinology Department, CHU Pellegrin, Bordeaux, France ) P2-65 Factors causing curved femur in elderly women ○ Hiroyuki Tsuchie, Naohisa Miyakoshi, Yuji Kasukawa, Yoichi Shimada (Deptartment of Orthopedic Surgery, Akita University Graduate School of Medicine) P2-66 Study of Bone Mineral Density of Female High School Long-Distance Track and Field Athletes ○ Kimiko Miyahara 1, Kiyomi Inoue 2, Keiki Ogino 3 (School of Nursing and Nutrition, Depertment of Nutrition, Shukutoku University1, Department of Nursing Faculty of Health Sciences, Kobe Tokiwa University2, Department of Public Health, Okayama University Graduate School Dentistry of Medicine and Pharmaceutical Sciences 3) P2-67 In patients with primary hyperparathyroidism , Blood Fetuin-A concentration reduced by parathyroidectomy ○ Masaya Ohara, Yasuo Imanishi, Katsuhito Mori, Masaaki Inaba (Internal Medecine, Osaka City Of University) P2-68 Bone mineral density and evaluation of fracture risk of cancer patients with disuse osteoporosis ○ Toshihisa Osanai (Department of Orthopaedic Surgery, Hokkaido Cancer Center) P2-69 Denosumab for low bone mass in hemodialysis patients: A non-controlled trial ○ Rikako Hiramatsu, Yoshifumi Ubara (Nephology Center, Toranomon Hospital) － 273 － P2-70 Examination of bone mineral density and bone turnover markers in the patients with rheumatoid arthritis and osteoporosis after denosumab and/or daily teriparatide ○ Yukio Nakamura 1, Tomohiko Yoshida 2, Hideshi Yamazaki 3, Takashi Miyazawa 4, Shigeharu Uchiyama1, Mikio Kamimura 5, Shota Ikegami 1, Hiroyuki Kato 1 (Department of Orthopaedic Surgery, Shinshu University School of Medicine 1, Toshin Toshida Naika Clinic, Setagaya Riumachi Kougenbyou Clinic 2, Marunouchi Hospital, Department of Rheumatology 3, Department of Orthopaedic Surgery, Showa-Inan General Hospital 4, Kamimura Clinic 5) Student-Resident Poster Presentation SRP-01 Functional analysis of a novel protein kinase in chondrocyte differentiation by using genome editing system ○ Yumiko Mori (Department of Molecular and Cellular Biochemistry, Osaka University School of Dentistry) SRP-02 The direct role of vitamin D on skeletal muscle mechanics ○ Megumi Mae (Nagasaki University School of Dentistry) SRP-03 Regulatory mechanism of Sema3A expression in osteoblast lineage cells ○ Ayano Inoue (Faculty of Dentistry, Tokyo Medical and Dental University) SRP-04 A Case of Bilateral Atypical Femoral Fractures in a Patient with Acquired Fanconi's Syndrome ○ Tomomi Sunayama (Department of Orthopedics, The University of Tokyo Hospital) SRP-05 3D analysis of allometric cranial base development ○ Mio Edamoto (Laboratory of Cell and Tissue Biology, Keio University School of Medicine) SRP-06 Effects of Dioscin, a steroidal saponin in fenugreek with reduced bitterness on ageing-induced bone loss in mice ○ Miona Hachisuka (Department of Nutrition and Life Science, Kanagawa Institute of Technology) SRP-07 The Fit Characteristics of KYOCERA J-Taper® : the Relation with the Femoral Canal Shape ○ Noriko Kanemaru (The Faculty of the Medicine of the University of Tokyo) SRP-08 Impact of RANK gene promotor methylation on osteoclastic differentiation of RAW cells ○ Yuki Murata (Ehime University School of Medicine) － 274 －
