Hematology Parameters for the Crl:CD® BR Rat

Hematology Parameters for the Crl:CD® BR Rat

Hematology Parameters
for the Crl:CD®BR Rat
February, 1993
Information Prepared by
Patricia L. Lang, Ph.D.
Consulting Toxicologist
Table of Contents
Introduction.................................................................................................................................................1
Acknowledgements ................................................................................................................................... 2
References ...................................................................................................................................................2
Definitions.................................................................................................................................................. 2
Table 1:
Methodology..................................................................................................................... 3-5
Table 2:
Methods Directory............................................................................................................... 6
Table 3:
Table 4:
Male CD® Rats .............................................................................................................. 7-10
Female CD® Rats ........................................................................................................ 11-14
Figure la:
Hemoglobin Male CD® Rats ........................................................................................... 15
Figure lb:
Hemoglobin Female CD® Rats ....................................................................................... 15
Figure 2a:
Hematocrit Male CD® Rats ............................................................................................. 16
Figure 2b:
Hematocrit Female CD® Rats ..........................................................................................16
Figure 3a:
Red Blood Cell Count Male CD® Rats .......................................................................... 17
Figure 3b:
Red Blood Cell Count Female CD® Rats ...................................................................... 17
Figure 4a:
White Blood Cell Count Male CD® Rats ...................................................................... 18
Figure 4b:
White Blood Cell Count Female CD® Rats ...................................................................18
Figure 5a:
Platelets Male CD® Rats .................................................................................................. 19
Figure 5b:
Platelets Female CD® Rats .............................................................................................. 19
Figure 6a:
Mean Corpuscular Volume (MCV) Male CD® Rats ....................................................20
Figure 6b:
Mean Corpuscular Volume (MCV) Female CD® Rats ................................................20
Figure 7a:
Mean Corpuscular Hemoglobin (MCH) Male CD® Rats ........................................... 21
Figure 7b:
Mean Corpuscular Hemoglobin (MCH) Female CD® Rats ........................................21
Figure 8a:
Mean Corpuscular Hemoglobin Concentration (MCHC) Male CD® Rats ...............22
Figure 8b:
Mean Corpuscular Hemoglobin Concentration (MCHC) Female CD® Rats ...........22
Figure 9a:
Prothrombin Time Male CD® Rats ................................................................................ 23
Figure 9b:
Prothrombin Time Female CD® Rats .............................................................................23
Figure 10a: Activated Partial Thromboplastin Time Male CD® Rats ............................................ 24
Figure 10b: Activated Partial Thromboplastin Time Female CD® Rats ........................................ 24
Figure lla: Clotting Time Male CD® Rats ........................................................................................ 25
Figure 1 1b: Clotting Time Female CD® Rats .................................................................................... 25
HEMATOLOGY PARAMETERS
FOR THE CrI:CD ® BR RAT
Normal or "expected" values for hematology and
serum chemistry are frequently sought by those
wishing to compare values assayed in their
laboratory or obtained in their research with values
commonly obtained in other laboratories.
Unfortunately, the conditions of the assay procedure
as well as the conditions and even the specifications
of the animals assayed are seldom the same between
laboratories and, in the case of outbred stocks, may
even vary over time due to small sampling sizes and
genetic drift in populations. Even if these variables
are taken into account, meaningful data on these
parameters are still often hard to obtain for several
reasons. Control group data published in the peerreviewed literature, which are often used to compile
listings of normal values, can be hard to locate. Even
though such data are reported in the literature along
with test group data, this information is not usually a
topic of the paper and, therefore, is commonly not
referenced by a keyword. For this reason, the
information is often overlooked by computerized
literature searches. In addition, published articles
only rarely refer to methodology used to obtain the
hematological values reported. As the data presented
here illustrate, different analytical methods and
equipment can result in considerably different values
for the same parameter. Moreover, other
environmental and technique related variables, such
as the method used to restrain the animals for blood
collection as well as the anatomic site from which the
blood was drawn (e.g., tail vein, orbital sinus, heart
puncture, abdominal aorta), can result in different
values for some of these parameters (1-8). For these
reasons, care should be taken in using these data
which cannot substitute for historical data collected
within a single institution.
groups of rats were either untreated or vehicle
controls in these studies. The actual health status of
the animals at the time of blood sampling was not
indicated in any of the study reports.
The data are separated by sex and presented in tables
by individual study group and time on study. Where
necessary, results were converted to match those
units more commonly used and presented here. Due
to the variation in methodology used to obtain these
values, and the intrinsic variation among the different
studies, it would be inappropriate and misleading to
combine individual group means into overall means
or medians.
Table 1 presents codes relating to the analytical
methods or instrumentation used to obtain the means
for each parameter measured in each study group.
These codes are identified in Table 2. Information is
arranged alphabetically by study code for easier
access. In study group A, methodology was changed
during the course of a study. Samples from the first
three intervals (1, 26 and 52 weeks) were analyzed
by the methods listed in the first column in Table 1,
and the last two intervals (78 and 104 weeks) were
analyzed by the methods in the second column. Table
1 also reports the start date (date of first dosing), the
vehicle administered to the control group (if any),
and the route of test article, or vehicle, administration
for each group of rats. The site of blood draw is not
given as it was not available in the final reports from
which these data were extracted. To determine the
age of the rats, add approximately 6 weeks to the
study interval since, in general, dosing started when
the rats were about 6 weeks of age.
Tables 3 (males) and 4 (females) present the mean
values reported for each parameter by study group. In
many cases, a single study group had blood analysis
performed at several different intervals, all of which
are reported here under the same study identification
code. Data in these tables are presented by increasing
study interval, and consequently by increasing
animal age. Study start dates (date of first dose) are
repeated here for your convenience, and the number
of animals comprising the means is also reported.
The information presented in this monograph was
obtained from toxicology studies designed to support
product registration. All studies were performed
under Good Laboratory Practice regulations of either
the US Food and Drug Administration or the
Environmental Protection Agency. All animals were
housed one per cage and fed Purina Rodent Chow
except for study groups HV and HY. Animals in
study group HV were housed 5/cage and fed a diet
identified in the report as certified rodent diet #1324;
animals in study group HY were housed 5/cage and
fed a rodent diet produced by K & K Greef. All
The graphs display the information in the tables,
showing the range of the means obtained from all of
the different methodologies.
1
ACKNOWLEDGMENTS:
Effect of Sampling Site and Collection Method on
Variations in Baseline Clinical Pathology
Parameters in Fischer-344 Rats. II. Clinical
Hematology, Fund. Appl. Tox., 7, 658-663 (1986)
6. Suber, R. L., and R. L. Kodell, The Effect of
Three Phlebotomy Techniques on Hematologic
and Clinical Chemical Evaluation in Sprague
Dawley Rats, Vet. Clin. Path., 14, 23-30 (1985)
7. Upton, P. D. and D. J. Morgan, The Effect of
Sampling Technique on Some Blood Parameters
in the Rat, Laboratory Animals, 9, 85-91 (1975)
8. Weingand, K. W., L. W. Odioso, G. W. Dameron,
et al., Hematology Analyzer Comparison: Ortho
ELT-8/ds vs Baker 9000 for Healthy Dogs, Mice
and Rats, Vet. Clin. Path., 21, 10-14 (1992)
Our thanks to Ella Davis and Theresa Rosati, who
did all of the data extraction, computer entry and
compilation for this publication.
REFERENCES:
1. Dameron, G. W., K. W. Weingand, J. M.
Duderstadt, et al., Effect of Bleeding Site on
Clinical Laboratory Testing of Rats: Orbital
Venous Plexus Versus Posterior Vena Cava, Lab.
Anim. Sci., 42 (3), 299-301 (1992)
2. Dohler, D.-D., A. von zur Muhlen, K. Gartner and
U. Dohler, Effect of Various Blood Sampling
Techniques on Serum Levels of Pituitary and
Thyroid Hormones in the Rat, J. Endocr., 74, 341342 (1977)
3. Friedel, R., I. Trautschold, K. Gartner, M. HelleFeldmann and D. Gaudssuhn, Einfluss
Verschiedener Methoden zur Blutgewinnung auf
Enzym-Aktivitaten im Serum Kleiner
Laboratoriumstiere, Z. Klin. Chem. Kiln.
Biochem., 13, 499-505 (1975)
4. Neptun, D. A., C. N. Smith and R. D. Irons, Effect
of Sampling Site and Collection Method on
Variations in Baseline Clinical Pathology
Parameters in Fischer-344 Rats. I. Clinical
Chemistry, Fund. Appl. Tox., 5, 1180-1185
(1985)
5. Smith, C. N., D. A. Neptun, and R. D. Irons,
DEFINITIONS
HPMC: Hydroxypropylmethylcellulose
RBC: Red Blood Cell Count
WBC: White Blood Cell Count
MCV: Mean Corpuscular Volume
MCH: Mean Corpuscular Hemoglobin
MCHC: Mean Corpuscular Hemoglobin
Concentration
PT: Prothrombin Time
AP7T: Activated Partial Thromboplastin Time
2
TABLE 1
METHODOLOGY
STUDY CODE
STUDY START DATE
VEHICLE
ROUTE OF ADMIN.
A
A
DW
EG
EH
5/27/82
El
EO
5/28/82
3/8/85
EZ
FA
11/12/86
7/27/88
FB
FC
NONE
2/6/85
10/8/86
NONE
0.2% HPMC
5/15/90
9/29/89
WATER
NONE
I0/12/89
9/7/89
0.2% HPMC
SALINE
MANNITOL
0.2% HPMC
NONE
SALINE
CITRATE
IV
GAVAGE
DIET
IV
DIET
_ <78 WEEKS
DIET
GAVAGE
GAVAGE
DIET
GAVAGE
SC INJECT.
>52 WEEKS
HEMATOLOGY
HEMOGLOBIN (Hb)
18
4
1
HEMATOCRIT (HCT)
1
6
18
1
1
4
1
6
6
RBC
6
18
1
I
6
6
6
1
1
1
6
6
6
WBC
18
4
4
6
1
1
1
6
6
6
6
PLATELET
1
6
22
1
1
4
6
6
6
6
MCV
3
6
18
4
1
6
6
1
6
6
6
MCH
MCHC
18
1
1
4
4
1
6
6
6
I
1
1
6
6
6
6
6
6
6
6
6
6
7
2
2
2
8
2
2
2
1
1
1
PT
2
2
APTT
2
2
2
2
18
CLOTTING TIME
STUDY CODE
STUDY START DATE
VEHICLE
ROUTE OF ADMIN.
6
1
2
2
FD
FE
FG
GA
GB
GC
3/1/90
9/22/88
GZ
HA
4/5/88
2/25/82
HC
HD
11/6/84
7/10/84
HE
0.2% HPMC
SALINE
10/8/85
2/12/88
0.2% HPMC
0.2% HPMC
8/17/87
2/9/83
0.2% HPMC
WATER
11/22/85
SALINE
5%
0.2% HPMC
SALINE
DEXTROSE
5%
DEXTROSE
GAVAGE
IV
GAVAGE
GAVAGE
GAVAGE
GAVAGE
GAVAGE
IV
GAVAGE
IV
IV
HEMOGLOBIN (Hb)
6
6
6
1
HEMATOCRIT (HCT)
RBC
6
1
12
6
6
13
1
6
6
6
18
1
1
1
1
1
1
1
1
18
1
1
1
WBC
14
6
6
I
18
6
1
1
1
14
I
PLATELET
1
6
6
1
6
1
1
1
MCV
18
3
6
6
6
1
MCH
I
6
6
1
18
6
1
1
1
1
MCHC
I
6
6
1
6
1
1
I
1
1
PT
APTT
2
2
1
18
18
2
1
2
1
2
2
2
2
2
1
2
2
2
2
HEMATOLOGY
CLOTTING TIME
15
13
2
TABLE 1
METHODOLOGY
STUDY CODE
STUDY START DATE
VEHICLE
ROUTE OF ADMIN.
HEMATOLOGY
HEMOGLOBIN (Hb)
HEMATOCRIT (HCT)
RBC
WBC
PLATELET
MCV
MCH
MCHC
PT
APTT
CLOTTING TIME
STUDY CODE
STUDY START DATE
VEHICLE
ROUTE OF ADMIN.
HEMATOLOGY
HEMOGLOBIN (Hb)
HEMATOCRIT (HCT)
RBC
WBC
PLATELET
MCV
MCH
MCHC
PT
APTT
CLOTTING TIME
(Continued)
HF
11/12/81
NACL+
TWEEN 20
SC INJECT.
HG
9/16/86
0.2% HPMC
HH
7/30/85
SALINE
HI
8/22/84
0.2% HPMC
HJ
4/19/83
SALINE
HK
12/13/88
0.2% HPMC
GAVAGE
GAVAGE
GAVAGE
I M INJECT.
GAVAGE
18
18
18
18
1
1
1
1
1
1
1
1
1
1
1
1
l
1
1
1
18
18
18
1
1
1
2
2
1
1
1
1
1
1
2
2
1
1
1
9
9
9
9
9
9
9
9
10
10
HQ
12/15/82
SALINE
HR
4/16/82
SALINE
HS
2/4/82
SALINE
HT
8/26/87
0.2% HPMC
HU
5/28/87
0.2% HPMC
IV
I M INJECT.
GAVAGE
GAVAGE
1
1
1
1
1
1
1
1
1
1
1
1
1
I
1
1
1
1
1
2
2
1
1
1
1
1
1
1
1
1
2
2
HL
11/14/83
5%
DEXTROSE
IV
HM
4/4/86
5%
DEXTROSE
IV
HN
7/13/83
SALINE
1
1
1
1
HP
11/11/86
0.2% HPMC
IV
HO
11/19/85
5%
DEXTROSE
IV
1
I
1
I
1
1
1
1
1
1
1
1
1
1
1
1
1
1
2
2
1
1
1
1
1
1
1
1
1
1
3
1
1
1
2
2
HV
12/15/87
SALINE
HW
10/17/84
NONE
HX
5/31/83
NONE
HY
11/16/83
NONE
GAVAGE
IV & IP
DIET
DIET
DIET
HZ
7/27/87
FORMULATION
GAVAGE
IA
1/6/87
5% GUM
ARABIC
GAVAGE
1
1
1
1
3
1
I
1
2
2
11
it
I1
11
11
11
12
13
14
14
15
12
13
14
14
14
4
4
4
4
4
4
4
4
16
1
1
1
1
3
1
1
1
2
2
4
4
4
4
4
4
4
4
5
5
13
13
13
_
GAVAGE
TABLE 1
METHODOLOGY
STUDY CODE
STUDY START DATE
VEHICLE
(continued)
HF
11/12/81
NACL +
TWEEN 20
SC INJECT.
HG
9/16/86
0.2% HPMC
HH
7/30/85
SALINE
HI
8/22/84
0.2% HPMC
HJ
4/19/83
SALINE
HK
12/13/88
0.2% HPMC
GAVAGE
GAVAGE
GAVAGE
I M INJECT.
GAVAGE
HEMOGLOBIN (Hb)
HEMATOCRIT (HCT)
RBC
WBC
PLATELET
MCV
MCH
MCHC
PT
APTT
CLOTTING TIME
18
18
18
18
1
1
1
1
1
1
1
1
1
1
1
1
1
1
I
1
18
18
18
1
1
1
2
2
1
1
1
1
1
1
2
2
1
1
l
STUDY CODE
STUDY START DATE
VEHICLE
HO
12/15/82
SALINE
HR
4/16/82
SALINE
HS
2/4/82
SALINE
HT
8/26/87
0.2% HPMC
IV
I M INJECT.
GAVAGE
1
1
1
1
1
1
1
1
1
1
1
2
2
1
1
I
ROUTE OF ADMIN.
HL
11/14/83
5%
DEXTROSE
IV
HM
4/4/86
5%
DEXTROSE
IV
I-I N
7/13/83
SALINE
9
9
9
9
9
9
9
9
10
10
1
1
1
1
HU
5/28/87
0.2% HPMC
GAVAGE
1
1
1
1
1
I
1
1
1
1
1
I
I
1
2
2
HP
11/11/86
0.2% HPMC
IV
HO
11/19/85
5%
DEXTROSE
IV
1
1
1
I
1
1
1
1
1
1
1
1
1
1
1
1
1
I
2
2
1
1
1
1
1
1
1
1
1
1
3
1
1
1
2
2
HV
12/15/87
SALINE
HW
10/17/84
NONE
HX
5/31/83
NONE
HY
1I/16/83
NONE
GAVAGE
IV & IP
DIET
DIET
DIET
HZ
7/27/87
FORMULATION
GAVAGE
IA
1/6/87
5% GUM
ARABIC
GAVAGE
1
1
1
1
3
1
1
1
2
2
11
ll
11
ll
11
11
12
13
14
14
15
12
13
14
14
14
4
4
4
4
4
4
4
4
16
1
1
I
1
3
1
1
I
2
2
4
4
4
4
4
4
4
4
5
5
13
13
13
GAVAGE
HEMATOLOGY
4,
ROUTE OF ADMIN.
HEMATOLOGY
HEMOGLOBIN (Hb)
HEMATOCRIT (HCT)
RBC
WBC
PLATELET
MCV
MCH
MCHC
PT
APTT
CLOTTING TIME
TABLE 1
METHODOLOGY
STUDY CODE
(continued)
lB
IC
ID
IE
IF
IG
IH
II
U
1K
IL
4/20/83
2/17/83
8/31/83
3/3/87
1/29/87
9/24/87
6/30/88
12/10/87
SALINE
0.2% HPMC
0.2% HPMC
7/29/83
NONE
1/29/87
0.2% HPMC
12/9/89
0.2% HPMC
NONE
NONE
NONE
NONE
ACETONE
GAVAGE
I M INJECT.
GAVAGE
GAVAGE
GAVAGE
DIET
DIET
DIET
DIET
DIET
DIET
HEMOGLOBIN (Hb)
1
1
1
1
16
12
12
9
1
1
1
1
1
1
16
HEMATOCRIT (HC1)
16
16
19
19
9
RBC
1
1
1
1
1
4
16
16
21
21
9
WBC
1
1
1
1
1
4
16
16
21
21
9
16
16
20
20
9
16
16
STUDY START DATE
VEHICLE
ROUTE OF ADMIN.
HEMATOLOGY
PLATELET
MCV
1
1
1
1
1
MCH
1
1
1
1
1
1
1
1
1
1
PT
2
2
AM
2
2
MCHC
CLOTTINGTIME
STUDY CODE
IM
IN
10
IP
1Q
IR
7/28/87
3/8/88
2/15/85
12/3/84
5/19/86
1 I/12/84
IS
4/10/84
0.1% CORN
NONE
NONE
NONE
NONE
NONE
NONE
DIET
DIET
DIET
DIET
DIET
DIET
DIET
HEMOGLOBIN (Hb)
4
4
4
4
4
4
4
HEMATOCRIT (HCT)
4
4
4
4
4
4
4
RBC
4
4
4
4
4
4
4
WBC
4
4
4
4
4
4
4
PLATELET
4
4
4
4
4
4
4
MCV
4
4
4
4
4
4
4
MCH
4
4
4
4
4
4
4
MCHC
4
4
4
4
4
4
4
STUDY START DATE
VEHICLE
OIL
ROUTE OF ADMIN.
HEMATOLOGY
PT
APTT
CLOTTING TIME
TABLE 2
METHODS DIRECTORY
HEMATOLOGY
1. Operator Reference Manual, #4201046, Rev. B. Dec., 1977. Coulter Electronic, Inc., 590 West Twentieth
Street, Hialeah, FL 33010.
2. Coagulyzer Instruction Manual, Rev. Oct., 1976. Sherwood Medical Industries, St. Louis, MO 63103.
3. Baker 810 Series Platelet Analyzer, Operator's Manual #DS-010, Jan. 1986. Baker Instruments Corp.,
Allentown, PA 18103.
4. Laser Hematology Counter,ELT-8, Ortho Instruments.
5. Photo-optical clot detection system, COAG-A-MATE
Diagnostics, Division of Warner-Lambert Company.)
®
X2. Organon Teknika Corp.. ( Formerly General
6. Baker Instruments 9000 Cell Counter.
7. Hirsh, J. Intern. Med. 147, 769-771, 1987.
8. Bau, D., Gallus, A., Hirsh, J., Cade, J., N. Engl. J. Med. 147, (1972).
9. Coulter S-Plus-IV.
10. MLA Electra 750.
11. Coulter Counter T 660, Coulter Electronics Limited.
12. Coulter Hemoglobinometer, Coulter Electronics, Inc..
13. Micro-Capillary Centrifuge Tube.
14. Coulter Cell Counter, Coulter Electronics, Inc..
15. Baker 810 Whole Blood Platelet Analyzer, Baker Instruments Corp..
16. Lancer Coagulyzer It, method modified from Quick, 1966 (J. Clin. Pathol. 45, 105).
17. Coulter Cell Counter ZF.
18. Coulter S Senior.
19. Clay Adams, Autocrit Centrifuge; Clay Adams, Inc..
20. Coulter Electronics, Platelet Analyzer (P260).
21. Coulter Electronics, Coulter Counter, Model ZBI.
22. Hycel #103 Platelet Counter, Boehringer Mannheim Diagnostics Co..
6
TABLE 3
MALE CD® RATS
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (HCT)
%
RBC
(1X10"6/ul)
WBC
(1X10"3/uI)
PLATELET
(I X 10"3/ul)
MCV
fl
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
A
1 WK
5/27/82
10
GZ
2 WKS
10/8/85
8
EZ
2 WKS
5/15/90
10
EZ
3 WKS
5/15/90
5
HA
4 WKS
2/12/88
9
HP
4 WKS
1I/11/86
9
HM
4 WKS
4/4/86
10
HO
4 WKS
11/19/85
10
HI
4 WKS
8/22/84
10
HL
4 WKS
11/14/83
it)
HN
4 WKS
7/13/83
5
HQ
4 WKS
12/15/82
10
14.94
39.71
6.14
7.01
961
65
24.7
37.5
10.61
30.64
4.42
7.27
16.02
42.60
6.87
14.82
1378
62
23.4
37.6
13.32
19.93
16.82
44.76
7.57
13.44
1154
59
22.2
37.6
12.86
18.14
15.48
42.34
7.80
10.79
1013
56
19.8
36.0
1 1.04
15.58
15.33
42.52
7.68
11.63
1202
55
19.4
36.0
10.71
18.33
15.56
42.48
7.63
10.79
15.50
44.50
8.10
12.30
14.80
42.63
7.46
9.64
15.60
43.05
7.63
8.37
15.56
43.26
7.69
6.58
16.11
43.97
7.71
9.83
56
20.6
36.9
1(1.35
15.19
56
19.3
35.2
58
20.1
35.0
10.60
17.01
57
20.2
36.5
56
20.1
35.8
58
20.9
36.7
12.99
19.27
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
g/dl
HEMOGLOBIN (Hb)
HEMATOCRIT (HCT)
%
RBC
(I X 10"6/ul)
WBC
(1 X 10 5 3/ul)
PLATELET
(I X 10"3/ul)
MCV
11
MCH
pg
g/dl
MCHC
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
HR
4 WKS
4/16/82
10
FD
4 WKS
3/1/90
10
FA
4 WKS
9/29/89
10
FC
4 WKS
9/7/89
10
FE
4 WKS
9/22/88
9
HC
5 WKS
8/17/87
10
HD
5 WKS
FE
5 WKS
9/22/88
5
GC
5 WKS
7/10/84
10
HA
6 WKS
2/12/88
3
15.19
40.19
7.21
10.40
16.70
44.30
7.85
16.78
1 108
57
21.3
37.7
13.69
22.31
15.55
43.61
7.86
14.03
1088
56
19.8
35.7
11.69
17.84
15.61
42.97
8.00
15.29
1090
54
19.5
36.3
11.25
14.78
15.59
43.27
7.20
12.78
1035
60
21.7
36.0
11.32
16.29
15.11
41.76
7.64
14.26
15.50
41.60
7.60
7.90
15.29
43.73
7.69
11.51
17.00
44.00
8.10
18.60
15.57
46.40
6.73
14.51
875
56
19.9
36.0
10.36
15.96
55
20.0
37.0
58
20.1
35.2
9.44
15.43
54
21.0
38.5
15.50
42.40
8.02
10.20
984
54
19.2
36.0
11.23
16.57
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (HCT)
%
RBC
(I X10"6/u I)
WBC
(1 X I 0"3/u I)
PLATELET
(1X10"3/ul)
MCV
11
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
HG
6 WKS
9/16/86
10
HH
6 WKS
7/30/85
10
HI
6 WKS
8/22/84
5
HI
6 WKS
4/19/83
10
FD
6 WKS
3/1/90
5
FA
6WKS
9/29/89
5
HK
6 WKS
12/13/88
15
HS
7 WKS
2/4/82
10
15.26
43.30
7.05
1 1.92
15.20
44.70
7.37
10.40
14.94
42.72
7.77
9.66
15.30
43.27
7.28
7.53
61
20.9
34.3
56
19.4
35.1
10.50
16.72
59
20.9
35.5
15.66
44.92
8.51
15.20
1144
53
18.4
34.9
10.96
18.28
15.70
47.40
7.65
14.(X)
1178
62
20.5
33.1
13.8
20.1
15.29
43.50
6.95
9.58
61
21.1
35.2
10.03
15.24
15.58
42.78
7.88
13.34
1086
54
19.8
36.4
12.66
18.36
56
21.2
38.2
_
70
24.3
34.9
2/9/83
10
HE
HF
5 WKS
5 WKS
I1/22/85
11/12/81
10
_
10
15.00
40.88
7.43
15.24
1057
55
20.2
36.7
10.74
17.80
_
184.8
62
22.3
36.0
HK
7 WKS
12/13/88
_
15
15.80
46.90
7.84
1 1.80
941
60
2(1.1
33.6
13.8
19.2
HT
8 WKS
8/26/87
10
HM
8 WKS
4/4/86
5
EH
13 WKS
7/27/88
10
15.85
44.12
7.32
15.42
15.78
43.12
8.19
12.56
62
21.4
35.1
10.61
18.56
53
19.46
36.76
10.36
15.36
15.77
45.06
8.64
12.82
I191
52
18.3
35.0
11.32
16.43
TABLE 3
MALE CD ® RATS
oo
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (HCT)
%
RBC
(1 X 10"6/ul)
WBC
(IX10"3/ul)
PLATELET
(I X 10"3/ul)
MCV
fl
MCH
pg
MCI-IC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
HF
13 WKS
11/12/81
10
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
UNITS
PARAMETER
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (HCT)
%
RBC
(1 X I0"6/ul)
WBC
(1 X 10"3/ul)
PLATELET
(1X10"3/ul)
MCV
11
MCH
pg
MCHC
g/dI
PT
(SEC)
APTT
SEC
CLOTTING TIME
(SEC)
1Q
13 WKS
5/19/86
10
16.40
50.70
9.75
14.50
913
52
16.9
32.4
16.80
50.60
9.47
11.50
939
53
17.8
33.3
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (HCT)
%
RBC
(1 X 10"6/u I)
(1X10"3/u I)
WBC
PLATELET
(I X10"3/ul)
MCV
fl
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
SEC
CLOTTING TIME
SE )
GB
17 WKS
11/6/84
5
15.60
36.00
7.10
12.00
50
21.7
43.0
HV
HW
13 WKS
13 WKS
12/15/87
10/17/84
15
_
40
15.84
45.66
7.60
19.00
1161
60
15.60
45.80
7.67
18.65
975
44.04
202.2
IR
1M
13 WKS
13 WKS
11/12/84
7/28/87
20
_
20
( Continued)
HX
13 WKS
5/31/83
35
FB
13 WKS
10/12/89
10
GC
13 WKS
7/10/84
10
HU
13 WKS
5/28/87
10
GB
13 WKS
11/6/84
10
GA
13 WKS
2/25/82
10
IA
13 WKS
1/6/87
12
El
13 WKS
2/6/85
9
DW
13 WKS
3/8/85
9
15.99
45.90
7.55
13.51
947
15.32
43.55
8.30
14.01
1034
53
18.5
35.2
11.42
18.79
15.90
46.00
7.74
15.30
867
15.49
42.33
8.13
13.80
1015
53
19.2
36.4
10.86
15.8
15.02
43.71
8.16
10.13
14.90
39.(x)
7.63
7.70
15.27
43.98
8.37
12.21
15.63
44.98
8.55
13.26
54
18.6
34.6
10.05
15.87
52
19.7
38.7
13.50
44.00
7.19
12.70
1329
61
18.8
31.1
13.30
23.50
53
18.42
34.94
9.81
16.06
53
18.5
35.0
9.8(1
18.60
204
189.6
IJ
13 WKS
9/24/87
10
1K
13 WKS
6/30/88
18
10
13 WKS
2/15/85
20
IP
13 WKS
12/3/84
19
IL
14 WK
12/10/87
10
EG
14 WKS
11/12/86
13
HU
17 WKS
5/28/87
5
El
17 WKS
2/6/85
4
GA
17 WKS
2/25/82
5
16.20
49.70
9.63
13.10
955
52
16.9
32.7
14.77
43.20
7.14
14.59
1132
14.74
43.28
7.13
15.11
1083
16.00
47.70
9.12
12.40
945
53
17.5
33.6
16.20
52.1(1
9.70
13.70
928
54
16.7
31.1
16.30
44.90
8.58
15.40
1035
15.15
41.68
8.09
14.57
1038
51
18.1
36.1
10.72
14.97
15.08
41.94
7.98
11.40
930
54
19.(1
35.7
11.32
19.88
15.60
43.97
8.35
13.50
15.10
38.30
7.76
6.80
54
18.85
35.65
9.57
17.27
50
19.7
39.9
HF
25 WKS
11/12/81
10
HY
25 WKS
11/16/83
8
IA
26 WKS
1/6/87
12
EO
26 WKS
10/8/86
10
FG
26 WKS
4/5/88
20
IB
26 WKS
4/20/83
9
IC
26 WKS
2/I7/83
10
HW
26 WKS
10/17/84
40
FIX
26 WKS
5/31/83
35
15.04
43.50
8.49
9.82
15.90
37.30
7.60
12.90
15.55
43.81
8.00
11.82
983
55
19.5
35.5
11.10
15.19
14.70
41.10
8.24
7.70
14.86
40.88
8.49
8.36
15.35
45.60
7.39
16.15
955
15.14
44.50
7.72
12.87
961
49
21.1
42.9
15.10
42.00
7.15
9.70
1480
59
21.1
35.7
12.30
16.40
15.22
40.59
8.13
17.89
52
17.8
34.7
9.74
15.18
16.70
50.00
8.93
10.(10
578
56
19.0
33.0
14.10
50
17.8
35.8
48
17.4
36.2
15.78
44.81
7.50
12.40
1054
60
194.4
230.4
50.1
49
18.1
37.2
HV
IQ
26 WKS
26 WKS
12/15/87
5/19/86
I5
20
16.00
48.70
9.35
12.00
904
52
17.1
32.8
TABLE 3
MALE CD ® RATS
(continued)
STUDY CODE:
A
IR
STUDY INTERVAL: 26 WKS
26 WKS
STUDY START DATE: 5/27/82
11/12/84
NUMBER OF ANIMALS:
10
_
20
PARAMETER
UNITS
16.78
HEMOGLOBIN (Hb)
g/dI
16.10
%
43.73
HEMATOCRIT (HCT)
50.20
9.44
RBC
(IX10^6/ul)
8.75
WBC
(IX10^3/ul)
8.10
11.60
PLATELET
(1X10^3/ul)
1404
931
MCV
fl
50
53
MCH
pg
19.2
17.1
g/dl
MCHC
38.1
32.1
VT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
_
IM
26 WKS
7/28/87
20
IN
26 WKS
3/8/88
10
IP
26 WKS
12/3/84
20
1K
26 WKS
6/30/88
20
15.00
48.10
9.22
12.30
1061
52
16.3
31.2
16.60
48.60
9.65
13.50
1052
50
17.3
34.3
16.40
45.80
9.66
10.80
887
47
16.9
35.7
15.06
44.55
7.61
11.85
988
STUDY CODE:
IL
STUDY INTERVAL: 32 WK
STUDY START DATE: 1 2/1 0/87
NUMBER OF ANIMALS:
10
PARAMETER
UNITS
g/dI
16.10
HEMOGLOBIN (Fib)
%
45.30
HEMATOCRIT (HCT)
(1 X 1 0^ 6/u I)
8.73
RBC
(1XIO"3/ul)
11.60
WBC
(1 X 1 0"3/ul)
1064
PLATELET
MCV
Il
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
_
HY
38 WKS
1 I /16/83
8
HY
HW
51 WKS
52 WKS
1 1/16/83
I 0/ 1 7/84
8
_
40
11X
52 WKS
5/3 I/83
35
14.48
43.40
7.10
12.16
851
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Fib)
g/dl
HEMATOCRIT (HCT)
%
RBC
(1X 10"6/ul)
WBC
(1 X1 0"3/u I)
PLATELET
(1X10"3/ul)
MCV
11
MCH
pg
MCHC
g/dI
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
IM
52 WKS
7/28/87
10
1K
52 WKS
6/30/88
30
15.60
44.60
9.11
5.80
1083
49
17.1
34.9
14.35
43.80
7.31
11.09
1063
16.50
51.00
9.36
9.50
409
54
18.0
33.0
14.30
16,90
49.00
8.85
12.60
509
56
19.0
34.0
13.30
15.36
45.10
7.95
14.65
966
IJ
10
26 WKS
27 WKS
9/24/87
2/15/85
18
_
9
IE
27 WKS
3/3/87
13
ID
27 WKS
8/31/83
14
15.24
41.40
8.03
11.95
14.96
41.23
8.31
6.57
53
19.1
36.6
10.9
16.37
50
18.2
36.3
15.90
43.10
9.32
11.50
911
46
17.1
36.9
14.94
43.56
7.37
11.57
1169
EO
52 WKS
I 0/8/86
18
IQ
52 WKS
_5/ I 9/86
19
IS
52 WKS
4/ 1 0/84
10
IR
52 WKS
1 1/1 2/84
10
15.01
40.91
8.00
12.38
53
18.5
35.8
15.60
45.40
8.99
10.20
867
51
17.4
34.5
14.90
44.90
8.46
6.00
903
53
17.6
33.1
IL
FG
27 WK
30 WKS
12/I0/87
4/5/88
10
_
3
16.20
45.40
8.62
15.(X)
1119
14.13
39.17
7.40
16.70
1008
53
19.0
35.9
10.77
15.03
A
52 WKS
5/27/82
10
IJ
52 WKS
9/24/87
10
IN
52 WKS
3/8/88
10
14.50
42.00
8.65
5.50
89 I
48
16.8
34.6
15.56
40.00
8.05
9.93
952
50
19.3
38.7
14.68
43.80
7.09
10.33
1123
15.40
45.40
9.(X)
7.60
1207
51
17.1
33.8
192.6
221.4
IP
52 WKS
12/3/84
10
10
52 WKS
2/15/85
10
IF
53 WKS
12/9/89
10
IL
53 WK
I 2/10/87
10
IM
56 WKS
7/28/87
10
HQ
56 WKS
1 2/15/82
5
1K
56 WKS
6/30/88
10
HW
66 WKS
10/17/84
40
HY
77 WKS
I 1/16/83
8
IQ
78 WKS
5/1 9/86
20
14.40
41.80
8.61
6.90
966
49
16.7
34.3
15.20
42.90
9.19
7.10
922
47
16.5
35.3
16.03
43.94
7.86
12.52
15.30
45.10
8.44
11.40
1148
16.50
48.70
9.31
9.10
1041
53
17.8
33.8
15.18
39.58
7.41
10.24
14.89
42.80
7.49
10.48
870
14.89
44.90
7.45
13.69
927
15.90
45.00
8.42
11.40
792
54
19
35
14.6
15.90
48.40
8.84
11.10
953
55
18.0
32.8
57
20.3
35.9
11.10
16.27
54
20.5
38.6
12.52
19.00
214.2
TABLE 3
MALE CD ® RATS
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (HCT)
75
RBC
(I X W6/dB
WBC
(1X111"3/ul)
PLATELET
(1 X 10"3/u I)
MCV
fl
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
IR
IS
78 WKS
78 WKS
I1/12/84
4/10/84
20
_
19
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
gtdl
HEMATOCRIT (HCT)
RBC
(1 X 10"6/ul)
(1 X I O"3/ul)
WBC
PLATELET
(IX10"3/ul)
MCV
11
pg
MCH
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
HY'
103 WKS
1 1/16/83
8
IJ
104 WKS
9/24/87
10
IP
104 WKS
12/3/84
15
IN
104 WKS
3/8/88
9
14.40
43.00
7.41
14.70
619
58
20.0
34.0
15.3
12.71
39.70
6.50
15.78
1277
12.60
39.40
7.01
9.00
939
56
18.1
31.9
13.00
38.90
7.20
5.50
1019
55
18.3
33.5
15.40
45.90
8.90
10.80
1006
52
17.4
33.7
15.40
45.10
9.21
10.20
938
49
16.7
34.1
(Continued)
A
78 WKS
5/27/82
10
IP
78 WKS
12/3/84
18
IJ
78 WKS
9/24/87
9
IN
78 WKS
3/8/88
10
IM
78 WKS
7/28/87
20
10
78 WKS
2/15/85
18
HX
79 WKS
5/31/83
35
IL
79 WK
12/10/87
10
IK
79 WKS
6/30/88
16
IK
98 WKS
6/30/88
10
14.40
39.92
7.47
11.56
1343
54
19.3
36.0
15.60
48.80
9.10
1(1.9(1
921
54
17.2
32.0
14.52
43.44
7.28
10.22
1063
1590
4750
8.09
1330
968
53
17.7
33.6
16.40
50.40
9.06
11.30
1057
56
18.2
32.6
15.20
48.10
8.94
13.60
1 102
54
16.0
29.8
15.40
46.30
7.50
12.51
1014
14.10
41.50
7.63
15.20
1 171
14.57
43.81
6.97
11.34
983
14.46
43.70
7.00
10.07
1027
217.8
STUDY CODE:
lI
STUDY INTERVAL: 106 WKS
STUDY START DATE:
1/29/87
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
gJdl
14.16
HEMATOCRIT (HCT)
%
41.25
RBC
(IXIO'6/ul)
6.85
WBC
(1 X I O'3/ul)
10.10
PLATELET
(1X1(1"3/ul)
1014
MCV
fl
60
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
IH
106 WKS
1/29/87
?
14.26
41.26
6.82
10.45
953
61
IM
10
104 WKS 104 WKS
7/28/87
2/15/85
_
17
1(1
13.80
39.70
7.56
7.30
1145
53
18.3
34.8
15.00
45.7(1
8.05
7.0(1
961
57
18.7
32.8
IG
104 WKS
7/29/83
50
6.53
17.00
10
104 WKS
5/19/86
17
IR
104 WKS
11/12/84
20
IS
104 WKS
4/10/84
20
A
104 WKS
5/27/82
10
IL
105 WK
12/I0/87
10
14,30
44.50
8.26
7.30
987
54
17.3
32.1
14.10
42.40
7.92
8.40
1026
54
17.8
33.3
13.70
39.20
7.98
6.20
926
49
17.2
35.0
12.18
36.07
7.27
11.54
1157
49
16.59
33.71
14.40
42.00
7.80
17.90
925
TABLE 4
FEMALE CD® RATS
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dI
HEMATOCRIT (HCT)
%
RBC
(1X10^6/ul)
WBC
(1 X 10"3/u I)
PLATELET
(1X10"3/ul)
MCV
Fl
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
A
I WK
5/27/82
8
GZ
2 WKS
10/8/85
9
EZ
2 WKS
5/15/90
14.39
37.94
6.00
4.89
1010
64
24.4
37.8
9.90
27.64
4.19
10.56
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dI
HEMATOCRIT (HCT)
`%
RBC
(I X 10^6/ul)
WBC
(I X I0^3/ul)
PLATELET
(1 X I 0^3/u1)
MCV
11
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
HR
4 WKS
4/16/82
10
FD
4 WKS
3/1/90
10
15.32
40.88
7.43
5.97
44.53
7.86
11.67
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (HCT)
%
RBC
(IX] 0'6/61)
WBC
(1X10^3/ul)
PLATELET
(IX I (1"3/ul)
MCV
II
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
HG
6 WKS
9/16/86
10
56
20.8
37.9
66
23.9
36.1
16.40
1 128
57
20.9
36.9
12.87
17.54
_
HA
4 WKS
2/12/88
10
EZ
3 WKS
5/15/90
5
10
15.83
43.50
7.01
13.55
1244
62
16.16
43.92
7.47
10.48
1049
59
14.61
40.60
7.32
1 1.58
22.6
36.4
13.13
17.59
FA
4 WKS
9/29/89
10
15.24
42.90
7.47
12.41
1 102
58
20.4
35.5
10.04
14.211
HP
4 WKS
HM
4 WKS
HO
4 WKS
HI
4 WKS
1
10
4/4/86
10
1I/19/85
10
8/22/84
10
15.44
42.71
7.61
15.33
42.81
7.34
14.74
42.59
7.25
10.58
1139
57
8.47
1151
56
14.80
43.30
7.49
6.60
21.6
36.8
12.88
13.60
19.9
35.5
10.51
12.33
19.8
36.1
9.92
14.98
21.1
36.0
9.57
10.84
59
20.0
34.5
59
20.6
34.8
9.94
FC
4 WKS
9/7/89
9
FE
4 WKS
9/22/88
9
HC
5 WKS
8/17/87
10
HD
5 WKS
2/9/83
10
HE
5 WKS
II/22/85
10
15.00
15.59
43.99
7.25
9.48
1 179
61
21.6
35.5
10.69
13.07
15.22
42.13
7.63
10.05
15.60
42.60
7.48
5.10
57
20.0
35.8
10.28
14.66
57
20.6
36.7
41.71
7.55
11.10
1201
55
19.9
36.0
10.53
13.53
59
HN
4 WKS
7/13/83
5
HQ
4 WKS
12/15/82
10
15.28
42.62
7.45
6.51
13.94
39.12
7.24
4.48
15.51
42.78
7.43
8.35
58
20.3
36.1
54
19.1
35.4
58
20.9
36.4
12.68
17.98
HF
5 WKS
11/12/81
10
FE
5 WKS
9/22/88
5
GC
5 WKS
7/10/84
10
HA
6 WKS
2/I2/88
14.34
41.46
7.10
6.32
16.00
41.00
7.60
10.60
15.89
46.50
7.13
10.67
961
59
20.4
34.8
9.31
12.86
54
21.1
38.8
15.12
42.10
7.25
10.32
1 163
58
20.9
35.9
10.16
15.20
15.30
42.03
7.72
8.70
983
56
19.7
35.9
10.57
12.20
9.54
_
HL
4 WKS
11/14/83
9
_
12.33
3
190.8
HH
lil
6 WKS
7/30/85
10
6 WKS
8/22/84
5
15.28
42.68
7.12
8.58
15.60
45.00
7.45
59
20.9
35.8
61
21.1
34.9
9.86
13.69
6.70
FD
HJ
6 WKS
4/19/83
10
6 WKS
3/1/90
5
14.90
42.80
15.67
44.09
15.52
43.82
7.68
7.04
7.40
7.02
56
19.6
35.0
9.66
14.24
60
21.0
35.6
7.69
10.20
1037
57
20.2
35 .4
_
13.14
17.84
FA
6 WKS
9/29/89
5
15.28
43.02
7.87
12.22
1079
55
19.5
35.5
10.04
14.56
_
HK
6 WKS
12/13/88
15
HS
7 WKS
2/4/82
10
15.90
47.60
7.91
10.20
1079
60
20.3
33.7
13.80
18.70
15.40
43.56
7.12
5.98
61
22.0
36.3
_
HK
7 WKS
12/13/88
15
H'I'
HM
8 WKS
8 WKS
8/26/87
111
4/4/86
5
16.20
46.10
8.05
8.60
987
16.06
44.93
7.46
15.98
43.78
8.06
6.90
57
20.2
35.3
13.90
62
21.2
34.8
12.80
11.25
10.26
15.52
55
20.0
36.8
9. %
13.68
HZ
13 WKS
7/27/87
10
15.24
42.31
7.67
13.35
1 109
57
19.6
35.1
10.23
14.94
TABLE 4
FEMALE CD ® RATS
(Continued)
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (1-ICT)
%
RBC
(I X 10^6/u1)
WBC
(IX10^3/ul)
PLATELET
(1X10^3/ul)
MCV
fl
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
_
EH
13 WKS
7/27/88
10
HF
13 WKS
11/12/81
10
HV
13 WKS
12/15/87
15
HW
13 WKS
10/I7/84
40
HX
13 WKS
5/31/83
35
FB
13 WKS
10/12/89
10
GC
13 WKS
7/10/84
10
HU
13 WKS
5/28/87
10
GB
13 WKS
11/6/84
10
GA
13 WKS
2/25/82
10
IA
13 WKS
1/6/87
12
El
13 WKS
2/6/85
9
15.63
44.27
7.78
9.60
1107
57
20.2
35.3
10.88
15.11
15.90
36.90
7.10
7.60
14.45
42.85
6.68
8.25
1116
64
15.46
44.90
6.67
14.38
1008
15.62
44.70
7.04
11.89
15.44
43.88
8.01
9.30
1063
55
19.3
35.2
10.91
17.14
16.00
45.80
7.94
11.77
766
15.21
41.91
7.60
8.75
981
56
20.1
36.1
10.21
14.08
15.20
44.18
8.14
8.10
14.80
39.90
7.44
5.80
14.79
42.70
7.75
7.08
55
18.9
34.7
9.60
14.17
54
20.1
37.5
13.30
43.00
6.89
9.50
1308
62
19.4
31.1
13.10
23.30
27.48
200.4
198
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (HCT)
%
RBC
(1X10"6/ul)
WBC
(1X10^3/u I)
PLATELET
(1X10"3/ul)
MCV
fl
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
DW
13 WKS
3/8/85
9
1R
13 WKS
11/12/84
20
IQ
13 WKS
5/19/86
10
IK
13 WKS
6/30/88
18
IJ
13 WKS
9/24/87
10
1P
13 WKS
12/3/84
20
IM
13 WKS
7/28/87
20
10
13 WKS
2/15/85
20
IL
14 WKS
12/10/87
10
EG
l4 WKS
11/12/86
13
HU
17 WKS
5/28/87
5
El
17 WKS
2/6/85
4
15.41
43.63
8.20
7.36
16.00
50.00
8.94
8.80
952
56
17.9
32.1
16.40
51.60
9.13
7.20
943
57
18.0
31.9
14.80
42.61
6.97
7.92
904
14.65
43.60
6.69
6.80
1059
15.20
48.20
8.31
8.00
941
58
18.3
31.5
16.20
50.80
8.99
8.00
939
57
18.1
32.0
15.30
43.80
8.30
8.90
878
53
18.0
35.0
15.90
44.30
8.09
10.60
1052
15.71
43.17
8.17
8.54
887
52
18.6
36.1
10.53
13.82
14.70
41.26
7.32
9.18
1024
58
20.1
35.4
10.40
18.50
15.48
44.30
8.08
7.88
STUDY CODE: STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (HCT)
%
(I X 10 2 6/u1)
RBC
(IX10^3/uI)
WBC
(I X 10^3/ul)
PLATELET
MCV
fl
MCH
pg
MCHC
p,/dl
PT
(SEC)
APTT
(SEC)
CLOTTINGTIME
(SEC)
GA
17 WKS
2/25/82
5
_
54
19.0
35.6
9.60
15.74
52
22.5
43.0
GB
HF
17 WKS
25 WKS
11/6/84
11/I2/81
5
_
10
_
14.60
38.70
7.31
5.30
14.98
43.40
7.84
6.16
14.70
34.20
6.50
6.5(1
53
20.1
38.1
56
19.2
34.7
9.52
15.34
52
22.8
43.4
56
19.2
34.9
9.29
13.33
184.8
55
19.3
35.2
9.26
14.54
HY
25 WKS
11/16/83
8
IA
26 WKS
1/6/87
12
EO
26 WKS
10/8/86
10
FG
26 WKS
4/5/88
20
1B
26 WKS
4/20/83
9
IC
26 WKS
2/17/83
10
HW
26 WKS
10/17/84
40
HX
26 WKS
5/31/83
35
HV
26 WKS
12/15/87
15
16.40
49.00
8.13
6.70
590
60
20.0
34.0
13.10
14.60
41.00
6.56
11.2(1
1584
63
22.2
35.3
12.30
19.70
14.01
37.32
7.12
10.19
14.77
41.56
7.08
9.70
929
59
20.9
35.5
10.68
13.39
15.30
42.80
7.96
5.80
15.22
42.33
7.87
4.41
15.74
45.00
6.84
10.94
628
15.22
43.70
7.23
10.14
54
19.1
35.5
54
19.2
35.8
15.17
43.01
6.86
8.02
911
63
201
231
55.02
52
19.0
37.2
TABLE 4
FEMALE CD ® RATS
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (HCT)
RBC
WBC
%
(1 X 10"6/ul)
(1X10"3/ul)
PLATELET
MCV
MCH
MCHC
PT
APTT
CLOTTING TIME
(1 X 10"3/ul)
fl
pg
g/dI
(SEC)
(SEC)
(SEC)
IQ
26 WKS
5/19/86
20
1R
26 WKS
11/12/84
20
A
26 WKS
5/27/82
10
IK
26 WKS
6/30/88
17
16.00
48.10
8.66
6.90
878
56
18.5
33.3
15.80
48.40
8.78
8.10
891
55
18.1
32.7
16.10
41.46
7.71
5.73
1 106
54
20.8
38.6
14.74
43.06
7.32
7.25
91 1
10
20
15.60
43.x)
8.44
6.40
772
52
18.6
35.6
16.20
46.90
8.61
8.6(1
994
55
18.9
15.60
47.20
8.50
7.00
952
56
18.4
34.6
IR
52 WKS
1 I / 12/84
10
IS
52 WKS
4/ 10/84
10
13.90
39.90
7.81
1.80
727
51
17.8
34.8
14.70
43.30
7.63
3.20
767
57
19.3
33.9
STUDY CODE:
STUDY INTERVAL:
IP
52 WKS
12/3/84
10
IN
52 WKS
3/8/88
10
IM
52 WKS
7/28/87
10
[O
_52 WKS
2/15/85
IO
14.20
41.00
7.86
3.00
715
52
18.1
34.7
15.30
45.10
7.95
3.70
935
57
19.2
33.8
14.70
41.50
7.73
2.70
879
54
19.1
35.5
14.90
42.00
8.16
4.00
755
51
18.2
35.5
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (HCT)
%
RBC
(I X 10^6/ul)
WBC
(1X10^3/ul)
PLATELET
(IX10^3/ul)
MCV
fl
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
56
20.0
35.6
10.62
15.16
15.60
49.00
8.36
5.70
412
59
19.0
32.0
13.30
HY
51 WKS
I 1 / 16/83
8
_
IM
26 WKS
7/28/87
FG
30 WKS
4/5/88
3
14.56
40.86
7.28
9.18
1056
HY
38 WKS
11/16/83
8
_
IN
26 WKS
3/8/88
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (HCT)
%
RBC
(I X I 0"6/ul)
WBC
(1 X I 0"3/ul)
PLATELET
(I X 10^3/ul)
MCV
fl
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
16.50
48.00
7.85
7.40
485
61
21.0
34.0
12.30
IP
26 WKS
12/3/84
20
(continued)
IO
26 WKS
2/15/85
21)
IE
27 WKS
3/3/87
13
15.39
42.27
7.56
6.91
15.23
41.77
7.69
5.39
33.1
15.20
42.00
8.34
8.10
804
51
18.2
36.1
57
20.4
36.2
10.31
14.47
55
20.1
36.4
HW
52 WKS
10/1784
40
HX
52 WKS
5/31 /83
35
EO
52 WKS
10/8/86
18
IQ
52 WKS
31551
20
15.77
45.30
7.43
9.69
774
14.28
42.30
6.52
9.53
15.08
41.58
14.70
7.52
7.98
57
19.8
35.4
196.8
225.6
IF
53 WKS
12/9/89
10
IL
53 WKS
12/10/87
10
HQ
56 WKS
12/15/82
5
IK
56 WKS
15.54
42.47
7.64
9.37
15.10
44.80
7.87
15.26
15.04
43.00
7.10
6.36
894
57
20.2
36.0
10.44
14.17
6.70
1010
41.18
7.36
6.84
56
20.7
37.1
12.70
18.08
6/30/88
9
ID
27 WKS
8/31/83
14
_
IL
27 WKS
12/10/87
I0
IJ
27 WKS
9/24/87
10
16.10
45.10
8.16
8.70
1045
14.10
41.40
6.50
6.18
990
A
52 WKS
5/27/82
10
IK
52 WKS
6/30/88
30
IJ
52 WKS
9/24/87
10
44.10
8.05
5.50
832
55
18.4
33.4
16.11
40.88
7.68
6.00
903
53
21.0
39.2
14.21
41.93
7.10
6.03
849
14.32
42.00
6.51
5.58
897
IM
56 WKS
7/28/87
10
11W
66 WKS
10/17/84
40
15.80
45.90
8.48
5.40
993
54
18.6
34.4
15.64
46.00
7.16
8.99
784
HY
77 WKS
11/16/83
8
_
16.20
46.00
8.01
7.70
593
57
20.0
36.0
14.50
2046
IQ
78 WKS
5/19/86
20
15.00
45.10
8.13
6.90
832
56
18.5
33.3
TABLE 4
FEMALE CD ® RATS
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (fib)
g/dl
HEMATOCRIT (HCT)
%
RBC
(1X10"6/ul)
WBC
(1 X 10 1'3/01)
PLATELET
(I X I0^3/ul)
MCV
11
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
IS
78 WKS
4/10/84
19
A
78 WKS
5/27/82
8
14.90
42.50
8.02
6.10
774
53
18.5
35.0
15.01
41.85
7.30
10.18
1 133
57
20.6
35.9
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dI
HEMATOCRIT (HCT)
%
RBC
(1X10"6/ul)
WBC
(1X10"3/ul)
PLATELET
(1X10"3/ul)
MCV
fl
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT
(SEC)
CLOTTING TIME
(SEC)
10
100 WKS
2/15/85
13
STUDY CODE:
STUDY INTERVAL:
STUDY START DATE:
NUMBER OF ANIMALS:
PARAMETER
UNITS
HEMOGLOBIN (Hb)
g/dl
HEMATOCRIT (HCT)
%
RBC
(I X 10^6/ul)
WBC
(IX10"3/ul)
PLATELET
(IX1(1"3/ui)
MCV
fl
MCH
pg
MCHC
g/dl
PT
(SEC)
APTT'
(SEC)
CLOTTING TIME
(SEC)
Il
106 WKS
1/29/87
?
1R
78 WKS
11/12/84
20
_
14.90
43.60
8.22
7.60
898
53
18.2
34.1
IP
1J
78 WKS
78 WKS
12/3/84
9/24/87
9
_
20
13.81
40.44
6.55
7.20
843
14.90
47.20
8.13
6.80
884
58
18.3
31.6
(Continued)
IN
78 WKS
3/8/88
10
IM
78 WKS
7/28/87
20
IO
78 WKS
2/15/85
20
IL
79 WKS
12/10/87
10
IK
79 WKS
6/30/88
15
FIX
79 WKS
5/31/83
35
IK
98
6/30/88
13
15.3(1
47.5(1
8.01
6.8(1
847
60
19.2
32.3
15.70
48.10
8.39
7.10
910
57
18.7
32.6
14.40
44.90
7.98
8.50
1030
56
18.1
32.1
13.90
40.60
6.79
10.10
1044
14.31
42.00
6.32
6.82
801
15.39
45.90
7.10
6.34
13.12
38.85
5.99
7.03
776
223.8
12.80
38.70
6.72
8.40
903
58
19.1
33.0
14.17
41.06
6.50
7.17
765
63
IIY
IJ
103 WKS
104 WKS
11/16/83
9/24/87
8
_
10
14.20
41.00
7.01
8.70
544
60
21.0
34.0
15.20
IH
106 WKS
1/29/87
'?
13.79
39.52
6.23
9.26
791
63
12.67
37.30
6.01
12.40
1119
IP
104 WKS
12/3/84
20
13.50
40.7(1
6.86
6.10
1018
60
20.0
33.2
IN
IM
104 WKS
104 WKS
3/8/88
7/28/87
_
9
_
16
13.20
40.30
6.58
3.40
871
62
20.3
32.8
13.30
38.30
6.80
5.40
781
57
19.7
34.7
IG
104 WKS
7/29/83
50
6.44
8.00
IQ
104 WKS
5/19/86
15
IR
104 WKS
11/12/84
19
IS
104 WKS
4/10/84
16
A
104 WKS
5/27/82
10
IL
105 WKS
12/10/87
10
12.60
40.80
6.61
7.20
925
63
19.4
31.0
13.20
39.40
7.(X)
5.60
799
56
18.9
33.5
14.00
39.10
7.35
4.10
768
53
19.1
35.8
15.22
44.82
8.20
5.85
832
55
18.6
33.9
13.30
38.90
6.60
11.60
944
FIGURE la
HEMOGLOBIN
MALE CD®') RATS
FIGURE lb
HEMOGLOBIN
FEMALE CD® RATS
15
FIGURE 2a
HEMATOCRIT
MALE CD® RATS
FIGURE 2b
HEMATOCRIT
FEMALE CD® RATS
16
FIGURE 3a
RED BLOOD CELL COUNT
MALE CD® RATS
FIGURE 3b
RED BLOOD CELL COUNT
FEMALE CD ® RATS
17
FIGURE 4a
WHITE BLOOD CELL COUNT
MALE CD® RATS
FIGURE 4b
WHITE BLOOD CELL COUNT
FEMALE CD ® RATS
18
FIGURE 5a
PLATELETS
MALE CD ® RATS
FIGURE 5b
PLATELETS
FEMALE CD ® RATS
19
FIGURE 6a
MEAN CORPUSCULAR VOLUME (MCV)
MALE CD® RATS
FIGURE 6b
MEAN CORPUSCULAR VOLUME (MCV)
FEMALE CD ® RATS
20
FIGURE 7a
MEAN CORPUSCULAR HEMOGLOBIN (MCH)
MALE CD® RATS
FIGURE 7b
MEAN CORPUSCULAR HEMOGLOBIN (MCH)
FEMALE CD® RATS
21
FIGURE 8a
MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION (MCHC)
MALE CD ® RATS
FIGURE 8b
MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION (MCHC)
FEMALE CD ® RATS
22
FIGURE 9a
PROTHROMBIN TIME
MALE CD® RATS
FIGURE 9b
PROTHROMBIN TIME
FEMALE CD ® RATS
23
FIGURE 10a
ACTIVATED PARTIAL THROMBOPLASTIN TIME
MALE CD® RATS
FIGURE 10b
ACTIVATED PARTIAL THROMBOPLASTIN TIME
FEMALE CD ® RATS
24
FIGURE 11a
CLOTTING TIME
MALE CD ® RATS
FIGURE 11b
CLOTTING TIME
FEMALE CD ® RATS
25
NOTES: