poster sessions

Transcription

poster sessions

POSTER
SESSIONS
www.eci-vienna2015.org
Editors:
ECI 2015 President Scientific Program Committee
Univ.-Prof. Dipl.-Ing. Dr. Barbara Bohle
Center for Physiology and Pathophysiology
Dept. of Pathophysiology/Division of Immunopathology
Medical University of Vienna
Währinger Gürtel 18-20, 1090 Vienna, Austria
[p]: 0043 1 40400 51140
[e]: [email protected]
ECI 2015 Congress President
ao. Univ. Prof. Dr. Winfried F. Pickl
Institute of Immunology
Medical University of Vienna
Lazarettgasse 19, 1090 Vienna, Austria
[p]: 0043 1 401 6033 245
[m]: 0043 664 800 1665 017
[e]: [email protected]
Coordination:
ECI 2015
c/o WMA Ltd.
Alser Strasse 4 • 1090 Vienna • Austria
t: +43 1 405 13 83 16
f: +43 1 407 82 74
e: [email protected]
www.eci-vienna2015.org
Abstract Processing: Manfred Vodrazka, www.medacad.org
Layout: Barbara Biegl, www.biegl-grafik.at
Photo Credits: Unless otherwise indicated all pictures
© ECI – European Congress of Immunology
Copyright © 2015 ECI
All rights reserved. No part of this publication may be reproduced, distributed or transmitted without the prior written permission of ECI.
Some information may be subject to change.
Information on Poster Presentations
Posters are numerically the major scientific presentations of the meeting. The majority of congress attendees present a poster showing
data and progress with their personal research. Posters offer an excellent opportunity for people interested in a particular topic to meet and
exchange ideas and network with other researchers. Posters should NOT be used to advertise a product or service. Like a paper, a poster abstract should detail the focus of the presentation and the way(s) in which it contributes to the body of knowledge in its field. Guided Poster
Sessions (Monday, Tuesday and Wednesday from 09:45 to 11:15) will be chaired by ECI faculty members and senior researchers within the
respective areas and should be used for communication and interaction with the poster presenters, who are requested to be at their posters
at these times.
Scientific posters are displayed in the poster area in the Exhibition Hall. Each poster will be displayed for one full day either on Monday, Tuesday or Wednesday. Each day, the posters are organized in thematic groups of approx. 20 posters:
POSTER SESSIONS
The scientific program is divided into 4 main topic tracks:
Track A: Adaptive Immunity
Track B: Diseases
Track C: Innate Immunity
Track D: Disease Intervention
Track E: Other
Additionally a fifth track (Track E) combining topics which do not fit within the four main tracks was introduced. The 4-track program will
streamline keynote lectures, symposia, workshops as well as guided poster walks in a way that will promote easy cross talk between the basic
topics and types of sessions planned. Poster presentations will follow this track logic and the according sessions are scheduled as follows:
Monday
(09:45 – 11:15)
Tuesday
(09:45 – 11:15)
Wednesday
(09:45 – 11:15)
Track A
Adaptive Immunity
Track B
Diseases
Track C
Innate Immunity
Track D
Disease Intervention
Track E
Other
P.A.01 - 10
P.B.01 - 14
P.C.01 - 08
P.D.01 - 10
P.E.01
P.A.11 - 19
P.B.15 - 28
P.C.09 - 16
P.D.11 - 18
P.E.02 - 03
P.A.20 - 28
P.B.29 - 42
P.C.17 - 24
P.D.19 - 27
P.E.04 - 05
During the guided poster sessions (09:45 – 11:15 on Monday, Tuesday and Wednesday) the presenters are required to stand by their posters to
deliver a concise poster presentation of not more than 3 minutes and to answer questions from delegates. During this time, one or two chairpersons per thematic group will visit each poster and ask the presenters to briefly present their findings.
SCHEDULE FOR POSTER MOUNTING AND POSTER REMOVAL / FLOOR PLAN
Poster Mounting
Poster Session
Poster Removal
Monday
07:30 - 08:30
09:45 – 11:15
18:00-19:30
Tuesday
07:30 - 08:30
09:45 – 11:15
18:00-19:30
Wednesday
07:30 - 08:30
09:45 – 11:15
16:00-17:45
All poster boards are marked with three color-coded poster numbers, one number for each day. You can find your individual poster board
number in the author index at the end of this publication. The second letter in your poster number indicates the thematic track your poster
is being presented in, e.g. P.A.01.01 is being presented in Track A – Adaptive Immunity. The areas of the respective tracks within the poster
exhibition are indicated in the floor plan on the next page. This should make it easy for you to locate your poster wall. Please visit the Poster
Information Desk located at the entrance of the exhibition area for any questions you might have regarding the poster presentations.
Poster Presentations at the 4th European Congress of Immunology - ECI 2015 - Vienna, Austria
1
Information on Poster Presentations
Please note that the organizers cannot assume any liability for loss or damage of posters displayed in the poster area. Posters need to be
removed on the day of presentation between 18:00 – 19:30 hrs strict (16:00 – 17:45 hrs on Wednesday).
Access after 19:30 hrs (17:45 hrs on Wednesday) is not possible! Posters not removed until 19:30 hrs on the day of presentation (17:45 hrs on
Wednesday), will be taken down by the staff of the conference center and will not be stored or sent to the authors after the meeting.
FORMAT
The usable surface on the poster board will be 90 cm width x 130 cm height. Only adhesive tape can be used to mount posters. Material will be
provided onsite.
Please note that due to new EACCME regulations, authors are requested to disclose possible conflicts of interest on the poster.
KEY WORDS
If you would like to search for specific posters by individual keywords please use one of the following options:
- the Abstract Book PDF on the USB device handed out to you together with your congress bag
- the online program planner which is available on our website: www.eci-vienna2015.org
- the mobile program app which is available for download in IOS- and Google Play Stores (search for ECI 2015)
If you prefer a printed version of the abstract book you can purchase one (EUR 12.-) at the onsite registration desk in the entrance area of the
congress venue.
EFIS POSTER PRESENTATION AWARDS
The EFIS proposes 12 Poster Presentation Awards for the best posters presented during the ECI 2015 in Vienna. The winners will receive a
EUR 300,- cash prize. Poster Chairpersons will evaluate all posters presented during the guided poster sessions. Award Candidate Posters will
be moved to a designated area (on the left when entering the exhibition / poster area) by the congress staff for further evaluation and will be
displayed during all congress days. Final decisions on winners will be made by an award jury on Wednesday.
Prizes will be awarded during the Closing and Award Ceremony on Wednesday, September 9, 17:45 – 18:45 hrs (Hall A).
2
Abstract Submission Statistics
Country
Abstracts
Germany
Austria
United Kingdom
Spain
France
Italy
United States
Brazil
Turkey
Australia
Iran, Islamic Republic of
Russian Federation
Netherlands
Switzerland
China
Poland
Sweden
Serbia
Czech Republic
Belgium
Taiwan
Hungary
Greece
India
Korea, Republic of
Ireland
439
311
229
186
172
148
105
102
79
75
75
73
68
65
63
50
48
44
40
37
37
35
34
34
34
27
Portugal
Bulgaria
Mexico
Finland
Algeria
Croatia
Ukraine
Japan
Tunisia
Canada
Singapore
Slovakia
Norway
Denmark
South Africa
Chile
Slovenia
Romania
Egypt
Iceland
Saudi Arabia
Colombia
Israel
Thailand
Argentina
Hong Kong
27
26
24
23
21
20
20
19
18
16
14
14
13
12
12
11
11
10
9
8
8
6
6
6
5
5
Kenya
Nigeria
Oman
Estonia
Georgia
Kuwait
Latvia
Lithuania
Luxembourg
New Zealand
Zimbabwe
Albania
Benin
Cameroon
Costa Rica
Indonesia
Iraq
Jordan
Kazakhstan
Libya
Malaysia
Morocco
Pakistan
Sri Lanka
Uruguay
Total
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
3013
500
450
400
350
250
200
150
100
50
0
Germany
Austria
United Kingdom
Spain
France
Italy
United States
Brazil
Turkey
Australia
Iran, Islamic Republic of
Russian Federation
Netherlands
Switzerland
China
Poland
Sweden
Serbia
Czech Republic
Belgium
Taiwan
Hungary
Greece
India
Korea, Republic of
Ireland
Portugal
Bulgaria
Mexico
Finland
Algeria
Croatia
Ukraine
Japan
Tunisia
Canada
Singapore
Slovakia
Norway
Denmark
South Africa
Chile
Slovenia
Romania
Egypt
Iceland
Saudi Arabia
Colombia
Israel
Thailand
Argentina
Hong Kong
Kenya
Nigeria
Oman
Estonia
Georgia
Kuwait
Latvia
Lithuania
Luxembourg
New Zealand
Zimbabwe
Albania
Benin
Cameroon
Costa Rica
Indonesia
Iraq
Jordan
Kazakhstan
Libya
Malaysia
Morocco
Pakistan
Sri Lanka
Uruguay
Number
300
Country
3
Index
MONDAY, SEPTEMBER 7, 2015 .............................................................................................................................................. 7
Posters of the Day according to Tracks A, B, C, D, E...........................................................................................................................................................8
Track A – Adaptive Immunity............................................................................................................................................................................................9
P.A.01 Lineage Commitment...................................................................................................................................................................... 9
P.A.02 Lymphocyte Tolerance and Memory................................................................................................................................................. 9
P.A.03 Antigen Processing and Presentation - Part 1.................................................................................................................................. 10
P.A.04 Th1 and Th2 Cells - Part 1............................................................................................................................................................... 11
P.A.05 Th17 Cells - Part 1.......................................................................................................................................................................... 12
P.A.06 Regulatory T Cells - Part 1.............................................................................................................................................................. 12
P.A.07 CD8+ T Cells - Part 1....................................................................................................................................................................... 13
P.A.08 φδ T Cells..................................................................................................................................................................................... 14
P.A.09 Germinal Centre Reaction - Part 1................................................................................................................................................... 15
P.A.10 B Cells in Autoimmunity and Tolerance........................................................................................................................................... 16
Track B – Diseases . ........................................................................................................................................................................................................ 17
P.B.01 Immunity to Bacterial Infection - Part 1.......................................................................................................................................... 17
P.B.02 Immunity to Bacterial Infection - Part 2........................................................................................................................................... 18
P.B.03 Immunity to Fungi, Helminths and Malaria..................................................................................................................................... 18
P.B.04 Primary Immunodeficiencies - Part 1.............................................................................................................................................. 20
P.B.05 Autoinflammatory Diseases........................................................................................................................................................... 21
P.B.06 Diseases - Inflammation - Part 1..................................................................................................................................................... 22
P.B.07 Neuroimmunology........................................................................................................................................................................ 22
P.B.08 Diabetes and (Chronic) Inflammatory Joint Diseases........................................................................................................................ 23
P.B.09 (Chronic) Inflammatory Joint Diseases - Part 1................................................................................................................................. 24
P.B.10 Inflammatory Skin and Joint Diseases............................................................................................................................................. 25
P.B.11 Allergen Specific Immune Responses - Part 1................................................................................................................................... 26
P.B.12 Allergic Disorders - Part 1............................................................................................................................................................... 27
P.B.13 Tumor Immunity - Part 1................................................................................................................................................................ 28
P.B.14 Tumorantigens and Tumorstroma................................................................................................................................................... 29
Track C – Innate Immunity.............................................................................................................................................................................................. 30
P.C.01 Granulocytes................................................................................................................................................................................ 30
P.C.02 NK and NKT Cells - Part 1............................................................................................................................................................... 31
P.C.03 Innate Lymphocytes...................................................................................................................................................................... 32
P.C.04 Immune Suppression..................................................................................................................................................................... 33
P.C.05 Dendritic Cell Biology - Part 1......................................................................................................................................................... 33
P.C.06 Pattern Recognition Receptors - Part 1........................................................................................................................................... 34
P.C.07 Cytosolic Sensing and Inflammasome............................................................................................................................................. 35
P.C.08 Cell Signaling - Part 1..................................................................................................................................................................... 36
Track D – Disease Intervention........................................................................................................................................................................................ 36
P.D.01 Bone Marrow Transplantation and GVHD - Part 1............................................................................................................................. 36
P.D.02 Vaccines - Part 1............................................................................................................................................................................ 37
P.D.03 Vaccines & Veterinary Immunology - Part 1..................................................................................................................................... 38
P.D.04 Immune Interventions in Autoimmunity - Part 1.............................................................................................................................. 39
P.D.05 Intervention & Therapy of Allergy - Part 1....................................................................................................................................... 39
P.D.06 Cancer Immunotherapy - Part 1..................................................................................................................................................... 40
P.D.07 Stem Cells & Cell Based Therapies - Part 1....................................................................................................................................... 41
P.D.08 Biomarkers of Human Immune Responses & Immunogenicity against Biopharmaceuticals - Part 1..................................................... 41
P.D.09 Bone Marrow Transplantation and GVHD - Part 2............................................................................................................................ 42
P.D.10 Immunomodulation by Nutrients & Vitamines................................................................................................................................ 43
Track E – Other............................................................................................................................................................................................................... 43
P.E.01 Structural Biology & Imaging of the Immune System....................................................................................................................... 43
TUESDAY, SEPTEMBER 8, 2015............................................................................................................................................ 45
Posters of the Day according to Tracks A, B, C, D, E.........................................................................................................................................................46
Track A – Adaptive Immunity.......................................................................................................................................................................................... 47
P.A.11 Lymphocyte Development - Part 1................................................................................................................................................. 47
P.A.12 Antigen Receptor Signalling........................................................................................................................................................... 47
P.A.14 Th1 and Th2 Cells - Part 2............................................................................................................................................................... 49
P.A.17 CD8+ T Cells - Part 2....................................................................................................................................................................... 51
P.A.19 Antibody Engineering and B Cell Effector Molecules........................................................................................................................ 53
Track B – Diseases.......................................................................................................................................................................................................... 53
P.B.15 Immunity to Virus Infection - Part 1................................................................................................................................................ 53
P.B.16 Immunity to Bacterial Infection and Parasites................................................................................................................................. 54
4
Index
P.B.17 Immunity to Parasite Infection....................................................................................................................................................... 55
P.B.18 Primary Immunodeficiencies - Part 2.............................................................................................................................................. 56
P.B.20 Inflammatory Bowel Disease.......................................................................................................................................................... 58
P.B.21 Neuroimmunology and Multiple Sclerosis....................................................................................................................................... 59
P.B.22 (Chronic) Inflammatory Joint Disease - Part 2.................................................................................................................................. 60
P.B.23 Animal Models of Autoimmunity.................................................................................................................................................... 61
P.B.24 Mediators of (Neuro) Immune Regulation....................................................................................................................................... 62
P.B.25 Allergen Specific Immune Response - Part 2.................................................................................................................................... 63
P.B.26 Allergic Disorders - Part 2............................................................................................................................................................... 64
P.B.28 Tumormarkers.............................................................................................................................................................................. 65
Track C – Innate Immunity..............................................................................................................................................................................................66
P.C.09 Innate Immunity - Inflammation - Part 1......................................................................................................................................... 66
P.C.10 NK and NKT Cells - Part 2............................................................................................................................................................... 68
P.C.11 Macrophages - Part 1..................................................................................................................................................................... 68
P.C.12 Macrophages - Part 2..................................................................................................................................................................... 69
P.C.13 Dendritic Cell Biology - Part 2......................................................................................................................................................... 70
P.C.14 Pattern Recognition Receptors - Part 2........................................................................................................................................... 71
P.C.15 Cytokines - Part 1.......................................................................................................................................................................... 72
P.C.16 Cell Signaling - Part 2..................................................................................................................................................................... 73
Track D – Disease Intervention........................................................................................................................................................................................ 73
P.D.11 Vaccines - Part 2............................................................................................................................................................................ 73
P.D.12 Vaccines & Veterinary Immunology - Part 2..................................................................................................................................... 74
P.D.13 Immune Interventions in Autoimmunity - Part 2.............................................................................................................................. 75
P.D.14 Cancer Immunotherapy - Part 2...................................................................................................................................................... 76
P.D.15 Cancer Immunotherapy - Part 3...................................................................................................................................................... 77
P.D.16 Immunotherapy for Infectious Diseases.......................................................................................................................................... 77
P.D.17 Biomarkers of Human Immune Responses & Immunogenicity against Biopharmaceuticals - Part 2...................................................... 78
P.D.18 Immunopharmacology.................................................................................................................................................................. 79
Track E – Other...............................................................................................................................................................................................................80
P.E.02 Immune Response in Aging & Systems Biology - Part 1..................................................................................................................... 80
P.E.03 Metabolism & Immunity................................................................................................................................................................ 81
Wednesday, September 9, 2015............................................................................................................................................ 82
Posters of the Day according to Tracks A, B, C, D, E......................................................................................................................................................... 83
Track A – Adaptive Immunity..........................................................................................................................................................................................84
P.A.20 Dynamics of T Cell Activation and Contraction - Part 1...................................................................................................................... 84
P.A.21 Lymphocyte Development - Part 2................................................................................................................................................. 84
P.A.23 Costimulatory Pathways in Immunity and Tolerance........................................................................................................................ 86
P.A.24 Th17 Cells - Part 2.......................................................................................................................................................................... 87
P.A.26 CD8+ T Cells - Part 3...................................................................................................................................................................... 88
P.A.28 Dynamics of T Cell Activation and Contraction - Part 2..................................................................................................................... 89
Track B – Diseases..........................................................................................................................................................................................................90
P.B.29 Immunity to Virus Infection - Part 2................................................................................................................................................ 90
P.B.30 Primary Immunodeficiencies - Part 3............................................................................................................................................... 91
P.B.31 Secondary Immunodeficiencies...................................................................................................................................................... 92
P.B.33 Enviromental and Genetic Factors in Autoimmunity........................................................................................................................ 94
P.B.34 Multiple Sclerosis.......................................................................................................................................................................... 95
P.B.35 Immuneregulation at Barrier Sites - Part 1....................................................................................................................................... 96
P.B.36 Immuneregulation at Barrier Sites - Part 2...................................................................................................................................... 97
P.B.37 Cytokines in Regulation of Disease................................................................................................................................................. 97
P.B.38 Allergen Specific Immune Response - Part 3.................................................................................................................................... 98
P.B.40 Myelo- and Lymphoproliferative Disorders.................................................................................................................................... 100
P.B.41 Atherosclerosis and Cardiovascular Diseases..................................................................................................................................101
P.B.42 Immunity to Virus Infection - Part 3...............................................................................................................................................102
Track C – Innate Immunity ........................................................................................................................................................................................... 103
P.C.17 Innate Immunity - Inflammation - Part 2........................................................................................................................................103
P.C.18 NK and NKT Cells - Part 3............................................................................................................................................................. 104
P.C.19 Macrophages - Part 3....................................................................................................................................................................105
P.C.20 Dendritic Cell Biology - Part 3....................................................................................................................................................... 106
P.C.21 Pattern Recognition Receptors - Part 3..........................................................................................................................................107
5
Index
P.C.22 Complement and Fc Receptors......................................................................................................................................................107
P.C.23 Cytokines - Part 2........................................................................................................................................................................ 108
P.C.24 microRNAs and Epigenetics......................................................................................................................................................... 109
Track D – Disease Intervention...................................................................................................................................................................................... 110
P.D.19 Vaccines for Infectious Diseases....................................................................................................................................................110
P.D.20 Vaccine Adjuvants........................................................................................................................................................................111
P.D.21 Intervention & Therapy of Allergy - Part 2......................................................................................................................................112
P.D.22 Cancer Immunotherapy - Part 4.....................................................................................................................................................112
P.D.23 Stem Cells & Cell Based Therapies - Part 2......................................................................................................................................113
P.D.24 Biomarkers of Human Immune Responses & Immunogenicity against Biopharmaceuticals - Part 3................................................... 114
P.D.25 Organ Transplantation..................................................................................................................................................................115
P.D.26 Immunosuppressive and Tolerogenic Treatment............................................................................................................................ 116
P.D.27 MHC and other Gene Polymorphisms in Health & Disease.............................................................................................................. 116
Track E – Other..............................................................................................................................................................................................................117
P.E.04 Immune Response in Aging & Systems Biology - Part 2...................................................................................................................117
P.E.05 Reproductive Immunology........................................................................................................................................................... 118
Author Index .....................................................................................................................................................................119
6
Monday
Monday, September 7, 2015
MONDAY
SEPTEMBER 7, 2015
7
Posters of the Day according to Tracks A, B, C, D, E
Monday
Track A – Adaptive Immunity
Track C – Innate Immunity
P.A.01 Lineage Commitment
P.C.01 Granulocytes
P.A.02 Lymphocyte Tolerance and Memory
P.C.02 NK and NKT Cells - Part 1
P.A.03 Antigen Processing and Presentation - Part 1
P.C.03 Innate Lymphocytes
P.A.04 Th1 and Th2 Cells - Part 1
P.C.04 Immune Suppression
P.A.05 Th17 Cells - Part 1
P.C.05 Dendritic Cell Biology - Part 1
P.A.06 Regulatory T Cells - Part 1
P.C.06 Pattern Recognition Receptors - Part 1
P.A.07 CD8+ T Cells - Part 1
P.C.07 Cytosolic Sensing and Inflammasome
P.A.08 γδ T Cells
P.C.08 Cell Signaling - Part 1
P.A.09 Germinal Centre Reaction - Part 1
P.A.10 B Cells in Autoimmunity and Tolerance
Track B – Diseases
Track D – Disease Intervention
P.B.01 Immunity to Bacterial Infection - Part 1
P.D.01 Bone Marrow Transplantation and GVHD - Part 1
P.D.02 Vaccines - Part 1
P.B.03 Immunity to Fungi, Helminths and Malaria
P.D.03 Vaccines & Veterinary Immunology - Part 1
P.B.04 Primary Immunodeficiencies - Part 1
P.D.04 Immune Interventions in Autoimmunity - Part 1
P.B.05 Autoinflammatory Diseases
P.D.05 Intervention & Therapy of Allergy - Part 1
P.B.06 Diseases - Inflammation - Part 1
P.D.06 Cancer Immunotherapy - Part 1
P.B.07 Neuroimmunology
P.D.07 Stem Cells & Cell Based Therapies - Part 1
P.B.08 Diabetes and (chronic) Inflammatory Joint Diseases
P.D.08 Biomarkers of Human Immune Responses & Immunogenicity
against Biopharmaceuticals - Part 1
P.B.09 (Chronic) Inflammatory Joint Diseases - Part 1
P.B.10 Inflammatory Skin and Joint Diseases
P.B.11 Allergen Specific Immune Responses - Part 1
P.D.10 Immunomodulation by Nutrients & Vitamines
P.B.12 Allergic Disorders - Part 1
P.B.13 Tumor Immunity - Part 1
P.B.14 Tumorantigens and Tumorstroma
Track E – Other
P.E.01 Structural Biology & Imaging of the Immune System
8
P.A.01 Lineage Commitment
Chairpersons: Francesca Barone; Birmingham, United Kingdom / Jochen Huehn; Braunschweig, Germany
Human peripheral CD4+ Vδ1+ γδT cells can develop into αβT cells
Monday
P.A.01.01
H. Ziegler1, C. Welker1, M. Sterk1, J. Haarer1, H. Rammensee2, R. Handgretinger1, K. Schilbach1;
Children’s University Hospital Tübingen, Tübingen, Germany, 2Abteilung Immunologie Interfakultäres Institut für Zellbiologie Eberhard Karls Universität Tübingen, Tübingen, Germany.
1
P.A.01.02
Absence of homeodomain transcription factor Nkx2-3 inhibits splenic stress hematopoiesis
P.A.01.03
Synergistic endothelial checkpoints govern the development of peripheral lymph nodes
D. Vojkovics, D. Kolláth, P. Balogh;
University of Pécs, Pécs, Hungary.
L. Onder1, E. Scandella1, H. Cheng1, F. Maier2, B. Becher2, J. V. Stein3, T. Rülicke4, B. Ludewig1;
1
Institute of Immunobiology, Kantonspital St. Gallen, St. Gallen, Switzerland, 2Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland, 3Theodor Kocher Institute, University of Bern,
Bern, Switzerland, 4Biomodels Austria, Vienna, Austria.
P.A.01.04 CD248 regulates mesenchymal cell differentiation to adipocytes and lymphoid stroma
N. Steinthal, A. J. Naylor, G. E. Desanti, S. Nayar, J. H. Caamaño, D. R. Withers, C. D. Buckley, F. Barone;
University of Birmingham, Birmingham, United Kingdom.
P.A.01.05
MiR221/222 functions in bone marrow residence of hematopoietic progenitors and plasma cells
G. Petkau, F. Melchers;
Max Planck Institute for Infection Biology, Berlin, Germany.
P.A.01.06 Aire expression is inherent to all medullary thymic epithelial cells during their differentiation program
H. Kawano, H. Nishijima, J. Morimoto, Y. Mouri, M. Matsumoto;
Institute for Enzyme Research, Tokushima University, Tokushima, Japan.
P.A.01.07
CCL2 and CCR2 in migration of thymic dendritic cells
O. Cédile, I. Frank, L. Østerby Jørgensen, A. Wlodarczyk, T. Owens;
Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
P.A.01.08 Epigenetic imprinting and horizontal transfer of tolerogenic properties of stromal cells in gut-draining lymph nodes
M. Pasztoi1, J. Pezoldt1, M. Beckstette1, M. Buettner2, M. Vital1, J. Schweer1, D. Fleissner1, K. Nordstroem3, S. Cording4, J. Walter3, U. Bode1, D. Pieper1, P. Dersch1, O. Pabst2, S. Floess1, J. Huehn1;
1
Helmholtz Centre for Infection Research, Braunschweig, Germany, 2Hannover Medical School, Hannover, Germany, 3Universität des Saarlandes, Saarbrücken, Germany, 4Institut Pasteur, Paris, France.
P.A.01.09 Lymphoid stroma pivotal regulator of tertiary lymphoid organ formation
S. Nayar1, J. Campos1, B. Glaysher2, J. Caamaño3, D. Withers3, K. M. Toellner3, S. A. Luther4, M. C. Coles2, C. D. Buckley1, F. Barone1;
1
CTIR, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, 2Centre of Immunity and Infection, University of York, York, United Kingdom, 3School of Immunity and
Infection, University of Birmingham, Birmingham, United Kingdom, 4Department of Biochemistry, University of Lausanne, Lausanne, Switzerland.
P.A.01.10
Non-hematopoietic cells in memory inflation
P.A.01.11
Spinster-homologue-2 (Spns2) controls S1P-driven lymphocyte egress from lymphoid organs
P.A.01.12
Design of a New Antibody Panel for Flow Cytometric Analysis of Human Cortical and Medullary Thymic Epithelial Cells
P.A.01.13
Control Of Thymic Medulla Homeostasis Is Distinct From The Impact Of Aire And The Mechanisms That Limit Foxp3+ T-cell Development
Z. Banki1, J. Colston2, L. N. Lee2, C. Willberg2, A. E. Denton3, H. Stoiber1, D. Holm-von Laer1, D. T. Fearon3, B. Ludewig4, P. Klenerman2;
1
Division of Virology, Medical University of Innsbruck, Innsbruck, Austria, 2Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom, 3Department of Medicine and
Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 4Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
S. Simmons1,2, E. Umemoto3, S. Fukuhara4, Y. Kitazawa5, M. Okudaira6, A. Inoue6, D. Motooka7, S. Nakamura7, T. Iida7, J. Aoki6, N. Mochizuki4, K. Matsuno5, K. Takeda3, M. Miyasaka8, M. Ishii1,2;
1
Immunology Frontier Research Center, Department of Immunology & Cell Biology, Osaka University, Osaka, Japan, 2Graduate School of Medicine, Department of Immunology & Cell Biology, Osaka
University, Osaka, Japan, 3Graduate School of Medicine, Laboratory of Mucosal Immunology, Osaka University, Osaka, Japan, 4National Cerebral and Cardiovascular Center Research Institute,
Department of Cell Biology, Osaka, Japan, 5Dokkyo Medical University, Department of Anatomy (Macro), Tochigi, Japan, 6Graduate School of Pharmaceutical Sciences, Laboratory of Molecular and
Cellular Biochemistry, Tohoku University, Sendai, Japan, 7Research Institute for Microbial Diseases, Department of Infection Metagenomics, Osaka University, Osaka, Japan, 8Graduate School of Medicine,
Laboratory of Immunodynamics, Osaka University, Osaka, Japan.
G. Terzioğlu1, F. T. Akdeniz2, Z. Akbulut2, B. Aru2, G. Yanıkkaya Demirel3;
1
Yeditepe University, Institute of Science and Engineering, Department of Biotechnology, İstanbul, Turkey, 2Yeditepe University, Institute of Health Sciences, Department of Molecular Medicine, İstanbul,
Turkey, 3Yeditepe University, Faculty of Medicine, Department of Immunology, İstanbul, Turkey.
N. I. McCarthy, J. Cowan, K. Nakamura, A. Bacon, S. Baik, A. White, S. Parnell, E. Jenkinson, W. Jenkinson, G. Anderson;
P.A.02 Lymphocyte Tolerance and Memory
Chairpersons: Martijn Nolte; Amsterdam, Netherlands / Stephen Schoenberger; La Jolla, United States
P.A.02.02
Receptor editing leading to B lymphocyte tolerance is governed by the L-type calcium channel Cav1.4
P.A.02.03
Exosomes containing miRNA-150 suppress protein-induced delayed-type hypersensitivity reaction in mice
P.A.02.04
Adeno Associated Virus mediated hepatic gene transfer induces specific humoral immune regulation
P.A.02.05
T cell regulator Cbl-b deficiency aggravates atherosclerosis via a CD8+ T cell phenotype
F. Fenninger, L. L. Nohara, W. A. Jefferies;
University of British Columbia, Vancouver, BC, Canada.
K. Bryniarski1, K. Nazimek1, M. Ptak1, P. W. Askenase2, W. Ptak1;
1
Department of Immunology Jagiellonian University College of Medicine, Krakow, Poland, 2Section of Allergy and Clinical Immunology, Yale University School of Medicine, New Haven, CT, United States.
V. Le Guen1, M. Berquez1, J. Judor1, F. Boeffard1, V. Gauttier1, N. Ferry2, S. Brouard1, S. Conchon1;
1
INSERM UMR 1064 Centre for Research in Transplantation and Immunology, Nantes, France, 2INSERM UMR 948, Nantes, France.
E. Smeets1, S. Meiler1, Q. Braster1, M. den Toom1, E. Lutgens1,2;
1
Academic Medical Center Amsterdam, Amsterdam, Netherlands, 2Institute for Cardiovascular Prevention (IPEK), Munich, Germany.
P.A.02.06 TCAIM regulates T cell activation and effector cell differentiation by inhibiting mitochondrial motility and mROS generation
J. Schumann1, K. Stanko1, C. Appelt1, F. Berberich-Siebelt2, A. Waisman3, B. Sawitzi1,4;
1
Institute for Medical Immunology, Charité University Medicine Berlin, Berlin, Germany, 2Institute of Pathology, Julius Maximilian-University Wuerzburg, Würzburg, Germany, 3Institute for Molecular
Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany, 4Berlin Brandenburg Center for Regenerative Therapies, Charité University Medicine Berlin, Berlin,
Germany.
P.A.02.07
Heterogeneity of EMRA CD4+ T-lymphocyte compartment(CD45RA+CCR7-) in HIV patients
A. Echeverría, M. A. Moro García, M. Iglesias Escudero, V. Corte Iglesias, R. Alonso Arias;
Hospital Universitario Central de Asturias, Oviedo, Spain.
P.A.02.08 Characterization of IL-10 producing B Helper T-cells in humans and mice that are increased in systemic lupus erythematosus patients
F. Facciotti1, M. Paroni1, A. Penatti2, N. Gagliani3, L. Pignataro4, S. Abrignani1, R. Flavell5, P. Meroni6, J. Geginat1;
1
INGM, Milano, Italy, 2Division of Rheumatology, Department of Clinical Sciences and Community Health, Gaetano Pini Orthopedic Institute, University of Milano, Milano, Italy, 3Department of
Immunobiology, School of Medicine, Yale University, New Haven, CT, United States, 4Department of Clinical Sciences and Community Health,Fondazione IRCCS Ca’ Granda Ospedale Maggiore
Policlinico,Università degli Studi di Milano,, Milano, Italy, 5Department of Immunobiology, School of Medicine, Yale University, Department of Immunobiology, School of Medicine, Yale University,, New
Haven,, CT, United States, 6Division of Rheumatology, Department of Clinical Sciences and Community Health, Gaetano Pini Orthopedic Institute, University of Milano,, Milano, Italy.
P.A.02.09 A novel function for memory CD8+ T-cells in the bone marrow: supporting the pool of hematopoietic stem cells
S. Geerman, M. F. Pascutti, S. Bhushal, M. A. Nolte;
Sanquin, Amsterdam, Netherlands.
9
Monday
P.A.02.10
IL-22 producing memory CD4+ T cells are present in the intestine early in human fetal development
P.A.02.11
High throughput analysis of the environmental adaptation of murine CD8+ tissue resident memory T cells
P.A.02.12
Reactivation of resting memory T cells from bone marrow
P.A.02.13
Maintenance of resting versus circulating memory T cells in humans
P.A.02.14
Investigation of the existance of the thyroid autoantibodies in patients with Type1 diabetes mellitus (DM)
P.A.02.15
Human breast milk-derived extracellular vesicles modulate CD4 T responses
P.A.02.16
Profiling the longitudinal changes of the antigen-specific B cell repertoire induced by vaccination
R. R. Schreurs1, W. B. Corpeleijn2, R. Bakx3, T. B. Geijtenbeek1, T. W. Kuijpers4, J. B. van Goudoever2, M. J. Bunders1,2,4;
1
Department of Experimental Immunology, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, Netherlands, 2Department of Pediatrics, Emma Children’s Hospital, AMC,
UvA, Amsterdam, Netherlands, 3Department of Pediatric Surgery, Pediatric Surgical Center, Emma Children’s Hospital, AMC and VUmc, Amsterdam, Netherlands, 4Department of Pediatric Hematology,
Immunology and Infectious Diseases, Emma Children’s Hospital, AMC, UvA, Amsterdam, Netherlands.
B. Érsek1,2, N. Lupsa1,2, P. Pócza3, E. Sarzsinszky1,2, A. Tóth1,2, A. Bencsik1,2, H. Hegyesi4, A. Matolcsy3, E. Buzás2, Z. Pós1,2;
1
MTA-Semmelweis University ”Lendület ’’ Experimental and Translational Immunomics Research Group, Budapest, Hungary, 2Dept. of Genetics, Cell and Immunobiology, Semmelweis University,
Budapest, Hungary, 31st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary, 4”Frédéric Joliot-Curie” Institute for Radiobiology and Radiohygiene,
Budapest, Hungary.
A. Okhrimenko1, C. Cendón1, M. MacGrath1, F. Siracusa1, T. Alexander2, A. Schulz1, A. Bruns2, C. Giesecke1, H. Mei1, P. Durek1, J. Gruen1, T. Dörner2, H. Chang1, A. Radbruch1, J. Dong1;
1
Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), an Institute of the Leibniz Association, Berlin, Germany, 2Charité-University Medicine, Berlin, Germany.
C. Cendon1, S. Reinke2, P. von Roth2, J. Gröne2, A. Okhrimenko1, C. Kebler2, G. Wassilew2, G. Puhl2, J. Wachtlin3, E. Zhang3, N. Barutcu4, J. Bodo4, H. Chang1, A. Radbruch1, J. Dong1;
1
Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), an Institute of the Leibniz Association, Berlin, Germany, 2Charité-University Medicine, Berlin, Germany, 3Sankt Gertrauden Krankenhaus, Berlin,
Germany, 4Plastische und Ästhetische Chirurgie, Berlin, Germany.
Ö. Cetinkaya, R. Kesli, E. Bozkurt, G. Asık, C. Demir, S. Çelik;
Afyon Kocatepe University, Afyonkarahisar, Turkey.
M. I. Zonneveld1,2, M. J. van Herwijnen2, S. S. Goerdayal3, M. Altelaar3, L. S. Taams4, J. Garssen1,5, F. A. Redegeld1, E. N. Nolte - ‘t Hoen2, M. H. Wauben2;
1
Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands, 2Department of Biochemistry & Cell Biology, Faculty of Veterinary
Medicine, Utrecht University, Utrecht, Netherlands, 3Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences,
Utrecht, Netherlands, 4Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection and Inflammatory disease, King’s College London, London, United Kingdom, 5Nutricia
Research Centre for Specialized Nutrition, Utrecht, Netherlands.
G. Schneikart, M. Bardelli, O. Finco, G. Del Giudice;
Translational Medicine, Novartis V&D, Siena, Italy.
Chairpersons: Kajsa M. Paulsson; Lund, Sweden / Katarzyna Nazimek; Krakow, Poland
P.A.03.01
Expansion of human antigen-specific memory CD4 T cells by artificial antigen presenting cells
P.A.03.02
HLA-B*2705 and its double implication in viral defense and autoimmunity: unpredicted presentation of an immunodominant viral epitope devoid of the classical
B27 binding motif
A. Garnier1, J. Latouche2, M. Hanieh2, A. Drouet2, E. Comby3, D. Mariotte3, B. Le Mauff1,3, O. Toutirais1,3;
1
INSERM U919, Caen, France, 2INSERM U1079, Rouen, France, 3Immunology and immunopathology laboratory University hospital of Caen, Caen, France.
V. Tedeschi1, C. Vitulano1, A. Cauli2, A. Mathieu2, F. Paladini1, D. Kormann3, R. Bockmann3, R. Sorrentino1, R. Sorrentino1, M. Fiorillo1;
1
Department Biology and Biotechnology ‘C. Darwin’, Sapienza, University of Rome, Rome, Italy, 2Rheumatology Unit, Department of Medical Sciences, University of Cagliari, Italy, Cagliari, Italy,
3
Computational Biology, University of Erlangen-Nürnberg, Erlangen, Germany, Erlangen, Italy.
P.A.03.03
Therapeutic Cancer Vaccine: Producing Dendritic Cell from Allogeneic Donor Stem Cells
P.A.03.04
Peptide expression context and its availability for processing as determinant of memory inflation and immune protection against cytomegalovirus
A. Unal, A. Birekul, M. Ç. Ünal, E. Karakuş, L. Kaynar, E. E. Turak, Y. Özkul, M. Çetin, H. Çelikzincir, Y. Köker, Ö. Özçoban, S. Şivgin, B. Eser;
Erciyes University, Kayseri, Turkey.
I. Dekhtiarenko1, J. Holzki1, R. Blatnik2, N. Lemmermann3, R. Holtappels3, M. Reddehase3, A. Riemer2, L. Cicin-Sain1,4;
Helmholtz Centre for Infection research, Braunschweig, Germany, 2German Cancer Research Center, Heidelberg, Germany, 3Johannes Guttenberg University, Mainz, Germany, 4Medical School Hannover,
Hannover, Germany.
1
P.A.03.05
Lymph node conduit composition determines efficiency of T cell-dependent immunity
R. Nadafi1, H. Veninga1, X. Stachtea2, N. J. Paauw1, E. D. Keuning1, A. Oosterhof3, T. H. Kuppevelt3, M. Maccarana2, A. Malmström2, J. M. den Haan1, R. E. Mebius1, R. M. Reijmers1;
1
VU University Medical Center, Amsterdam, Netherlands, 2Department of Experimental Medical Science, Lund University, Lund, Sweden, 3Department of Biochemistry, Radboud Institute for Molecular Life
Science, Radboud University Medical Center Nijmegen, Nijmegen, Netherlands.
P.A.03.06 DC subpopulation specific changes of the cross-presentation machinery under inflammatory conditions
A. Baranska1, J. Sander2, C. H. Lehmann1, C. Gerlach3, N. Eissing1, G. F. Heidkamp1, K. Neubert1, R. Spang4, E. Krüger5, A. Voigt5, K. Hildner6, K. Hildner6, F. Nimmerjahn7, J. Schultze2, D. Dudziak1;
1
University Hospital Erlangen, Dept of Dermatology, Laboratory of DC Biology, Erlangen, Germany, 2University of Bonn, LIMES - Life and Medical Sciences Center, Genomics and Immunoregulation,
Bonn, Germany, 3University Hospital Jena, Department of Human Genetics, Jena, Germany, 4University of Regensburg, Institute for Functional Genomics, Computational Diagnostics Group, Regensburg,
Germany, 5Charité Universitätsmedizin Berlin, Institute of Biochemistry, Berlin, Germany, 6University Hospital Erlangen, Medical Department I, Laboratory of Dendritic Cells in Mucosal Immunology,
Erlangen, Germany, 7University of Erlangen, Department of Biology, Chairpersons: of Genetics, Erlangen, Germany.
P.A.03.07
Tannic acid modified silver and gold nanoparticles as stimulators of dendritic cells maturation in vitro
P. Orlowski1, E. Tomaszewska2, M. Gniadek3, G. Celichowski2, J. Grobelny2, M. Krzyzowska1;
Military Institute of Hygiene and Epidemiology, Warsaw, Poland, 2University of Lodz, Lodz, Poland, 3University of Warsaw, Warsaw, Poland.
1
P.A.03.08 Generation of allergen-specific T cell stimulator cells to investigate coinhibitory pathways in allergy
S. Rosskopf, S. Jutz, M. R. Candia, J. Leitner, A. Neunkirchner, W. F. Pickl, P. Steinberger;
Institute of Immunology - Medical University of Vienna, Vienna, Austria.
P.A.03.09 The role of peptide: MHC complexes and KIR interactions in the pathogenesis of Ankylosing Spondylitis
D. M. Wellington, T. Elliott, E. James;
University of Southampton, Southampton, United Kingdom.
P.A.03.10
Dendritic cell derived exosomes induce CD8+ T cell responses independently of MHC class I engagement by delivering whole antigen
P.A.03.11
Differential fold-stability during endolysosomal maturation determines immunogenicity and allergenicity of the major birch pollen allergen
P.A.03.12
The human cytomegalovirus (HCMV) encoded immunoevasin US11 selectively degrades only HLA-A alleles; are HLA-B alleles targets of a novel mechanism by
US11?
P. Larssen1, S. Hiltbrunner1, M. Martinez-Bravo1, A. Wagner2, M. Karlsson2, S. Gabrielsson1;
1
Department of Medicine, Translational Immunology unit, Karolinska Institutet, Stockholm, Sweden, 2Department of Microbiology, Tumor and Cellbiology, Karolinska Institutet, Stockholm, Sweden.
Y. J. Machado1, R. Freier1, S. Scheiblhofer1, T. Thalhamer1, M. Mayr1, P. Briza1, S. Grutsch2, L. Ahammer2, J. E. Fuchs3, H. G. Wallnoefer3, A. Isakovic1, V. Kohlbauer1, A. Hinterholzer1, M. Steiner1, M. Danzer4,
J. Horejs-Hoeck1, F. Ferreira1, K. R. Liedl3, M. Tollinger2, P. Lackner1, C. M. Johnson5, H. Brandstetter1, J. Thalhamer1, R. Weiss1;
1
University of Salzburg, Department of Molecular Biology, Salzburg, Austria, 2University of Innsbruck, Center of Molecular Biosciences & Institute of Organic Chemistry, Innsbruck, Austria, 3University of
Innsbruck, Center of Molecular Biosciences & Institute of General, Inorganic and Theoretical Chemistry, Innsbruck, Austria, 4Austrian Red Cross, Blood Transfusion Service for Upper Austria, Linz, Austria,
5
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
C. Zimmermann1, D. Kowalewski2, V. Le-Trilling3, S. Stevanović2, H. Hengel1, A. Halenius1;
Institute of Virology, University of Freiburg, Germany, 2Department of Immunology, University of Tübingen, Germany, 3Institute for Virology, University Hospital Essen, Germany.
1
10
P.A.03.13
Immunogenicity DRB3, DRB4 and DRB5 regard DRB1
P.A.03.14
Comparison of indirect fluorescent antibody test (IFAT) with indirect haemagglutination test (IHAT) for the diagnosis of hydatid cyst disease
E. A. Gonzalez-Navarro, M. Juan Otero;
Hospital Clinic, Barcelona, Spain.
Ö. Cetinkaya1, R. Kesli1, G. Asık1, Ö. Yoldas1, C. Demir1, D. Çufalı1, B. Pektaş2;
1
Afyon Kocatepe University, School of Medicine, Department of Medical Microbiology, Afyonkarahisar, Turkey, 2Katip Çelebi University, Atatürk Training and Research Hospital, Department of Medical
Microbiology, Izmir, Turkey.
P.A.03.15
Immunization with immune complexes modulates the fine-specificity of antibody responses to a flavivirus antigen
G. Tsouchnikas1, J. Zlatkovic1, J. Jarmer1, J. Strauß1, O. Vratskikh1, M. Kundi2, K. Stiasny1, F. X. Heinz1;
Department für Virologie, Wien, Austria, 2Institute of Environmental Health, Wien, Austria.
1
P.A.03.16
Design of Chimeric Proteins Derived from Adhesin Regions of Mycoplasma pneumoniae for Vaccine Development
P.A.03.17
HLA class I immunopeptidome analysis of melanoma cell lines
P.A.03.18
Large-scale HLA peptidome analysis of small cell lung carcinoma for development of personalized immunotherapy
A. Gloger1, T. Fugmann2, D. Ritz2, D. Neri1;
1
ETH Zurich, Zurich, Switzerland, 2Philochem AG, Otelfingen, Switzerland.
A. Admon, S. Kalaora, M. Melchers, D. Melamed, E. Barnea;
Technion-Israel Institute of Technology, Haifa, Israel.
Monday
C. Chen1,2, Y. Qi1, T. Xu1,3, Y. Pan1, S. Li1, J. Li1, S. Li1,3, X. Wang1,2, Y. Xu1,2, Y. Li1;
1
Huadong Research Institute for Medicine and Biotechniques, Nanjing, China, 2School of Life Science and Technology,China Pharmaceutical University, Nanjing, China, 3School of Basic Medicine, Nanjing
Medical University, Nanjing, China.
Chairpersons: Claudia Kemper; London, United Kingdom / Peter Steinberger; Vienna, Austria
P.A.04.01 Effect of 1,25-dihydroxyvitamin D3 on the Th1/Th2 balance and nitric oxide in type 1 diabetes
L. Ysmail-Dahlouk, M. Aribi;
Laboratory of Applied Molecular Biology and Immunology. University of Tlemcen, Tlemcen, Algeria.
P.A.04.02
Addressing the complexity of antigen specific CD4+ T cell responses in cancer patients
P.A.04.03
Repertoire of gluten immunogenic peptides in pediatric celiac disease after a brief oral wheat consumption
C. Costa-Nunes1, C. Jandus1, P. Baumgaertner1, S. M. Pedro2, F. Sandoval2, O. Adotévi3, D. Speiser1, R. Pedro1;
1
Ludwig Center for Cancer Research, Lausanne, Switzerland, 2Glaxo Smith Kline, Brussels, Belgium, 3CHU Besançon, Besançon, France.
S. Picascia1, M. Hardy2,3, R. Auricchio4, L. Greco4, J. Tye-Din2,3,5, C. Gianfrani1;
1
Institute of Protein Biochemistry – CNR, Naples, Italy, 2Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, 3Department of Medical Biology,
The University of Melbourne,, Parkville, Victoria, Australia, 4Department of Translational Medical Science (DISMET), Section of Pediatrics, University of Naples Federico II, Naples, Italy, 5Department of
Gastroenterology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.
P.A.04.04 Common mechanisms of T cell antigen recognition in Celiac disease
J. Petersen1, Y. Kooy-Winkelaar2, J. van Bergen2, S. E. Broughton1, R. P. Anderson3, P. A. Price4, H. H. Reid1, F. Koning2, J. Rossjohn1;
Monash University, Melbourne, Australia, 2Leiden University Medical Center, Leiden, Netherlands, 3The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, 4Institute of Infection and
Immunity,Cardiff University, Cardiff, United Kingdom.
1
P.A.04.05 Co-inhibitory receptors in human malaria
A. Abel1, M. Mackroth1,2, C. Schramm2, T. Jacobs1;
1
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, 2University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
P.A.04.06 Evaluating the applicability of the CRISPR/Cas system in human T cells
I. Hartl, K. Pfisterer, H. Stockinger, A. Ohradanova-Repic;
Medical University of Vienna, Vienna, Austria.
P.A.04.07 Intrinsic and extrinsic mediated CTLA-4-signals modulate the TH2-response during allergic diseases
M. Pierau, M. C. Brunner-Weinzierl;
Department of Experimental Paediatrics, Otto-von-Guericke University, Magdeburg, Germany.
P.A.04.08 Th1/Th2 Cytokine Profiles In Type-2 Diabetes Mellitus Patients
R. Khanferyan1, N. Janaeva2, N. Riger1, V. Muslimova3, H. Janaeva3;
1
Institute of Nutrition, Moscow, Russian Federation, 2Clinical center, Urus-Martan, Russian Federation, 3Clinical center “Planet of Health”, Urus-Martan, Russian Federation.
P.A.04.09 Folate deficiency affects cytokine profiles and function of T helper cells and correlates with lower antigen presenting capacity of dendritic cells
C. Wu, B. Lin;
Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan.
P.A.04.11
Towards a non-allergenic peptide mix containing the T cell epitopes of the clinically most relevant house dust mite allergens for tolerance induction
P.A.04.12
Inflammatory Th1 and Th17 cells employ different transcriptional networks to regulate self-regulatory IL-10 expression
P.A.04.13
T-bet- and STAT4-dependent IL-33 receptor expression amplifies antiviral Th1 cell responses
H. Huang1, M. Curin1, S. Banerjee1, K. Chen1, T. Garmatiuk1, Y. Resch1, R. Campana1, M. Focke-Tejkl1, R. Valenta1, S. Vrtala1,2;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophy, Vienna, Austria, 2Christian Doppler Laboratory for the Development of Allergen Chips, Vienna,
Austria.
C. Neumann1,2, F. Heinrich1, K. Neumann2, A. Kühl3, M. Heimesaat4, S. Rutz5, A. Scheffold1,2;
1
German Rheumatism Research Center, Berlin, Germany, 2Charité University Hospital, Department of Rheumatology and Clinical Immunology, Berlin, Germany, 3Charité University Hospital, Medical Clinic
I, Gastroenterology, Berlin, Germany, 4Charité University Hospital, Department of Microbiology and Hygiene, Berlin, Germany, 5Genentech, Department of Immunology, San Francisco, CA, United States.
C. Baumann1,2, W. V. Bonilla3, A. Fröhlich1,2, C. Helmstetter1,2, M. Peine1,2, D. D. Pinschewer3, M. Löhning1,2;
Charité–Universitätsmedizin, Berlin, Germany, 2German Rheumatism Research Center (DRFZ), Berlin, Germany, 3Division of Experimental Virology, Department of Biomedicine, University of Basel, Basel,
Switzerland.
1
P.A.04.14 The impact of binuclear (η6-p-cymene)ruthenium(II) complex containing bridging bis(nicotinate)-polyethylene glycol ester ligand (4) on T lymphocyte polarization
S. Stosic-Grujicic1, M. Momcilovic1, M. Vujicic1, J. Blazevski1, T. Eichhorn2, G. Kaludjerovic3;
1
Institute for Biological Research ‘’Sinisa Stankovic’’, University of Belgrade, Belgrade, Serbia, 2Institute of Chemistry, Martin Luther University, Halle, Germany, 3Leibniz Institute of Plant Biochemistry,
Halle (Saale), Germany.
P.A.04.15
A study of immunophenotypic reference values for T-cell subsets
A. Oras1, T. Giese2, R. Uibo1;
1
Department of Immunology, Institute of Bio- and Translational Medicine, University of Tartu, Tartu, Estonia, 2Institute of Immunology, Heidelberg University, Heidelberg, Germany.
P.A.04.16 Identification of a T cell discriminating molecule by TCR/CD3 complex immunization
K. Mahasongkram, S. Pata, N. Chruewkamlow, W. Kasinrerk;
Biomedical Technology Research Center, Division of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
P.A.04.17
A key role for A-type lamins in naïve T-cell differentiation
M. Blanco-Berrocal1, R. Toribio-Fernandez1, S. Iborra1, C. Rius1, G. Martinez del Hoyo1, V. Rocha-Perugini1, D. Sancho1, F. Sanchez-Madrid2, V. Andres1, J. M. Gonzalez-Granado1;
1
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain, 2Servicio de Inmunología, Hospital de la Princesa, Madrid, Spain.
P.A.04.18 Anti-microbial immune profiling in obstructive lung diseases
F. Jaat1, S. Hasan1, C. Lanyon1, A. De Soyza2, S. Todryk1;
1
Northumbria University, Newcastle Upon Tyne, United Kingdom, 2Newcastle University, Newcastle Upon Tyne, United Kingdom.
P.A.04.19 Immune abnormalities in patients of Pemphigus Vulgaris
V. Mehrotra1, G. Awasthi2;
1
Himalayan Institute of Medical Sciences, Dehradun, India, 2Dolphin Institute of Biomedical Sciences, Dehradun, India.
P.A.04.20 Resveratrol and a novel resveratrol-salicylate hybrid molecule: a comparative study in CD4+ T cells
K. Goldhahn1, F. Aldawsari2, K. Schmetterer3, G. Steiner4, C. Velazquez-Martinez2, B. Kloesch1;
1
Ludwig Boltzmann Institute for Rheumatology and Balneology, Vienna, Austria, 2Faculty of Pharmacy and Pharmaceutical Science, Edmonton, QC, Canada, 3Medical University of Vienna, Clinical Institute
of Laboratory Medicine, Vienna, Austria, 4Medical University of Vienna, Department of Internal Medicine III, Division of Rheumatology, Vienna, Austria.
P.A.04.21
Interplay between GSK-3β and Notch pathways is crucial in LFA-1 signalling for T-cell migration and effector functions
F. M. Turabe1, A. Kottaiswamy1, S. T. Ong1, M. L. Chalasani1, P. Prasannan1, S. Kumar2, A. K. Panda3, D. Kelleher4, N. K. Verma1,5;
1
Lee Kong Chian School of Medicine, Singapore, Singapore, 2Institute of life sciences, Bhubaneswar, India, 3Central University of Jharkhand, Ranchi, India, 4Imperial College London, London, United
Kingdom, 5Singapore Eye Research Institute, Singapore, Singapore.
11
P.A.04.22
The role of Egr2 and Egr3 in the tolerance mechanism
B. Omodho1, R. Singh1, A. Ogbe1, A. L. Symonds1, T. Miao1, P. Wang2, S. Li1;
1
Brunel University, London, United Kingdom, 2Queen Mary University, London, United Kingdom.
Chairpersons: Christina Zielinski; München, Germany / Bor-Luen Chiang; Taipai, Taiwan
Monday
P.A.05.01
The role of NFκB inducing kinase (NIK) in T-cells and EAE
P.A.05.02
Macrophage PTEN regulates expression and secretion of Arginase I modulating innate and adaptive immune responses
S. M. Lacher, A. Waisman;
Institute for Molecular Medicine (IMM), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
E. Sahin1, J. Brunner1, J. Kral1, K. Thell1, A. Halfmann2, A. Dohnal2, L. Chen3, P. Cheng3, M. Kuttke1, T. Haider4, B. Niederreiter5, V. Saferding5, S. Blüml5, G. Schabbauer1;
Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria, 2Children’s Cancer Research Institute, Vienna, Austria, 3Biocancer Treatment International, Hong Kong, China,
4
Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria, 5Division of Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria.
1
P.A.05.03
The oral commensal bacterial species Streptococcus mitis shows a Th17-dominated memory T cell signature that is similar to and cross-reactive with Streptococcus
pneumoniae
S. A. Engen1, H. V. Rukke1, D. Jarrossay2, I. S. Blix1, F. Sallusto2, K. Schenck1;
1
University of Oslo, Oslo, Norway, 2Institute for Research in Biomedicine, Bellinzona, Switzerland.
P.A.05.04 Uremic toxin SDMA promotes TH17 differentiation in a NO dependent manner
L. Dong, H. Haller, S. von Vietinghoff;
Hannover Medical School, Hannover, Germany.
P.A.05.05
A SNP in the IL-23R gene fosters Th17 response in AS
J. Fessler, M. Stradner, D. Peischler, W. Graninger, J. Hermann;
Medical University Graz, Graz, Austria.
P.A.05.06 The effect of tetanus neurotoxin Hcc protein on TNF-α, IL-4 and IL-17 transcript and protein level from normal human peripheral T cells
H. Ghoghaei1, A. Afkham1, S. Sadreddini1, S. Sadreddini1, V. Younesi2, M. Yousefi1;
1
Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, ,, Tabriz, Iran, Islamic Republic of, 2Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR,
Tehran, Iran, Islamic Republic of.
P.A.05.07
Evidence for a pathogenic role of auto-reactive Th1/17 cells in multiple sclerosis
M. Paroni1, V. Maltese1, M. DeSimone1, S. Maglie1, C. Fenoglio2, M. De Riz2, M. Pagani1, S. Abrignani1, D. Galimberti2, E. Scarpini2, J. Geginat1;
1
INGM, milano, Italy, 2Neurology Unit, Dept. of Pathophysiology and Transplantation, University of Milan, Fondazione Cá Granda, IRCCS OspedalePoliclinico, milano, Italy.
P.A.05.08 Differential mucosal expression of Th17 related genes between inflamed and non-inflamed colon of patients with Crohn’s disease
R. Marrakchi1, A. Abidi1, B. Neili1, A. Gati1, M. Feki2, A. Benammar Elgaaied1;
1
1Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences, University of Tunis El, Tunis, Tunisia, 22 La Rabta Hospital, Bab Saadoun Tunis, Tunisia, Tunis, Tunisia.
P.A.05.09 Sodium chloride drives immunoparalysis and anti-inflammatory Th17 cell properties
J. Matthias, R. Noster, C. Zielinski;
Technical University Munich, München, Germany.
P.A.05.10
c-MAF enhances a transcriptional program favouring immune-regulatory over pro-inflammatory human memory T lymphocytes
P.A.05.11
Demethylation of the RORC2 and IL17A in human CD4+ T lymphocytes defines Th17 origin of non-classic Th1 cells
P.A.05.12
Limited proliferative capacity of human T helper 17 cells
P.A.05.13
Triggering complement receptors on DCs promotes immediate Th17 polarization during HIV-1 infection
P.A.05.14
The tyrosine kinase Tec regulates Th17 responses
D. Aschenbrenner1, M. Foglierini1, D. Jarrossay1, D. Hu2, V. Kuchroo2, A. Lanzavecchia1,3, F. Sallusto1, S. Notarbartolo1;
1
Institute for Research in Biomedicine, Bellinzona, Switzerland, 2Center for Neurologic Disease, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, 3Institute of
Microbiology, ETH, Zurich, Switzerland.
A. Mazzoni1,2, V. Santarlasci1, L. Maggi1, M. Capone1, M. Rossi1, V. Querci1, G. Montaini1, R. De Palma2, H. Chang3, A. Thiel4, F. Liotta1, L. Cosmi1, E. Maggi1, A. Radbruch3, S. Romagnani1, J. Dong3, F.
Annunziato1;
1
University of Florence, Florence, Italy, 2Second University of Naples, Naples, Italy, 3Deutsches Rheuma-Forschungszentrum, Berlin, Germany, 4Berlin Brandenburg Center for Regenerative Therapies, Berlin,
Germany.
V. Santarlasci1, L. Maggi1, A. Mazzoni1, M. Capone1, V. Querci1, M. C. Rossi1, G. Montaini1, L. Beltrame2, D. Cavalieri3, R. De Palma4, F. Liotta1,5, L. Cosmi1,5, E. Maggi1,5, S. Romagnani1, F. Annunziato1,5;
1
Department of Experimental and Clinical Medicine and DENOTHE Center, University of Florence, Florence, Italy, 2Department of Oncology Mario Negri Institute, Milano, Italy, 3Department of
Computational Biology, Comparative Genomics Unit, Fondazione Edmund Mach (FEM), San Michele all’Adige, Italy, 4Dept. of Clinical & Experimental Medicine, Second University of Naples and Centro di
Competenza Regionale GEAR (Genomics for Applied Research), Naples, Italy, 5Regenerative Medicine Unit and Immunology and Cellular Therapy Unit of Azienda Ospedaliera Careggi, Florence, Italy.
W. Posch1, A. Schroll1, C. Lass-Flörl1, A. Saez-Cirion2, T. Geijtenbeek3, G. Weiss1, D. Wilflingseder1;
1
Medical University of Innsbruck, Innsbruck, Austria, 2Institut Pasteur, Paris, France, 3Center for Experimental and Molecular Medicine AMC, Amsterdam, Netherlands.
N. Boucheron1, O. Sharif2, L. Van Greuningen1, L. Göschl3, S. Knapp4, W. Ellmeier1;
1
Institute of Immunology, Center for Physiology, Pathophysiology and Immunology, Vienna, Austria, 2Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, 3Division of
Rheumatology, Medicine III, Medical University of Vienna, Vienna, Austria, 4Center for Molecular Medicine of the Austrian Academy of Sciences and Department of Medicine I, Division of Infectious Diseases
and Tropical Medicine, Vienna, Austria.
Chairpersons: Andreas Beilhack; Würzburg, Germany / Lesley A. Smyth; London, United Kingdom
P.A.06.01 The endocannabinoid 2-Arachidonoylglycerol potentiates Foxp3 expression and T regulatory cell functions through its metabolism: endocannabinoids as novel
mediators of Treg immunosuppressive activity.
V. Chiurchiu1, A. Leuti2, M. De Bardi3, T. Bisogno4, F. Piscitelli4, V. Di Marzo4, G. Borsellino3, M. Maccarrone2, L. Battistini3;
1
Neurochemistry of Lipids, Santa Lucia Foundation, Rome, Italy, 2School of Medicine and Center of Integrated Research, Campus Bio-Medico University of Rome, Rome, Italy, 3Neuroimmunology Unit,
Santa Lucia Foundation, Rome, Italy, 4Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy.
P.A.06.02 The expression of CD39 and PD1L by regulatory T cells correlates with the development of different forms of Chagas disease
M. P. Damásio1, G. R. Sousa1, R. Corrêa-Oliveira2, K. S. Ferreira1, V. A. Valente1, A. D. Araújo1, N. I. Medeiros2, F. F. de Araújo2, M. O. Rocha1, J. A. Gomes1;
1
Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, 2Centro de Pesquisa Rene Rachou, Belo Horizonte, Brazil.
P.A.06.03 Mechanisms of Foxp3 induction by DNA methyltransferase inhibitors
S. Schallenberg1, K. Freudenberg1, N. Lindner1, K. Kretschmer1,2;
1
Molecular and Cellular Immunology/Immune Regulation, DFG-Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany, 2Paul Langerhans Institute Dresden
(PLID), German Center for Diabetes Research (DZD), Dresden, Germany.
P.A.06.04 The impact of hypoxia inducible factor-1 alpha stabilization on differentiation and metabolism of human regulatory T cells
L. Feldhoff1, C. Rueda2, M. Fields2, C. Chougnet2, J. Rupp1;
1
Department of Molecular and Clinical Infections, University of Luebeck, Luebeck, Germany, 2Division of Cellular and Molecular Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH,
United States.
P.A.06.05 Decreased HIV-specific T-regulatory responses are associated with effective DC-vaccine induced immunity
V. Brezar1, N. Ruffin1, L. Richert2, M. Surenaud1, C. Lacabaratz1, K. Palucka3, R. Thiébaut2, J. Banchereau1, Y. Levy1, N. Seddiki1;
1
INSERM U955, Eq16, VRI, UPEC, Creteil, France, 2Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France, 3Ralph M. Steinman Center for Cancer Vaccines, Baylor
Institute for Immunology Research, Baylor Research Institute, Dallas, TX, United States.
P.A.06.06 The role of CalDAG GEFI during Treg-specific immunological synapse formation
J. Niemz1, R. Teich1, M. van Ham2, J. Wissing2, L. Philipsen3, S. Kliche3, L. Jänsch2, J. Huehn1;
1
Helmholtz Centre for Infection Research, Experimental Immunology, Braunschweig, Germany, 2Helmholtz Centre for Infection Research, Cellular Proteomics, Braunschweig, Germany, 3Otto-von-Guericke
University, Institute of Molecular and Clinical Immunology, Magdeburg, Germany.
12
P.A.06.07 Functional impairment and inflammatory changes of FoxP3+ regulatory T cells in human acute viral infection
J. Lee1, Y. Choi1,2, E. Shin1;
1
KAIST, Daejeon, Korea, Republic of, 2Chungnam National University College of Medicine, Daejeon, Korea, Republic of.
P.A.06.08 The role of integrin αv in regulatory T cell function
P.A.06.09 Regulatory T cells in experimental periapical lesions development: exploiting its protective role as a therapeutic tool
C. F. Francisconi1, A. C. Araújo-Pires1, C. C. Biguetti1, A. E. Vieira1, F. Cavalla1, A. J. Glowacki2, C. S. Sfeir2, S. R. Little2, A. P. Trombone3, R. M. Silva4, G. P. Garlet1;
Bauru School of Dentistry, University of São Paulo, Bauru, Brazil, 2University of Pittsburgh, Pittsburgh, PA, United States, 3Sacred Heart University, Bauru, Brazil, 4School of Dentistry, University of Texas
Health Science Center at Houston, Texas, TX, United States.
1
P.A.06.10 Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors
V. Adoue1,2,3, N. Thiault1,2,3, J. Darrigues1,2,3, M. Gros1,2,3, B. Binet1,2,3, C. Perals1,2,3, B. Leobon4, N. Fazilleau1,2,3, O. Joffre1,2,3, E. Robey5, J. van Meerwijk1,2,3, P. Romagnoli1,2,3;
1
INSERM U1043 Center of Pathophysiology Toulouse Purpan, 31024 Toulouse cedex 3, France, 2Centre National de la Recherche scientifique (CNRS) U5282, Toulouse, France, 3Université Paul Sabatier,
Toulouse, France, 4Cardiology department, Children’s hospital Purpan, 31024 Toulouse, France, 5Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of
California, Berkeley, CA, United States.
Monday
I. Mair, R. A. O’Connor, N. C. Henderson, S. M. Anderton;
University of Edinburgh, Edinburgh, United Kingdom.
P.A.06.11 Abatacept (CTLA-4Ig) treatment reduces T cell apoptosis and regulatory T cell suppression in patients with rheumatoid arthritis (RA)
M. Bonelli, L. Goeschl, S. Blueml, T. Karonitsch, S. Carl-Walter, S. Guenter, J. S. Smolen, C. Scheinecker;
Medical University of Vienna, Department of Rheumatology, Vienna, Austria.
P.A.06.12 HDAC-inhibitory activity of butyrate decreases regulatory T-cell function by inducing expression of IFN-gamma
M. Kespohl, N. Vachharajani, S. Hartmann, S. Alnahas, U. Steinhoff, A. Visekruna;
Institute for Medical Microbiology and Hygiene, 35032 Marburg, Germany.
P.A.06.13
Presence of tumor-infiltrating regulatory T cell subsets according to the differential expression of the immune checkpoints in human lung cancer
P. Devi1,2,3, J. Goc1,2,3, C. Germain1,2,3, S. Knockaert1,2,3, P. Validire1,4, D. Damotte1,5, W. Fridman1,2,3, C. Sautès-Fridman1,2,3, M. Dieu-Nosjean1,2,3;
1
Institut national de la sante et de la recherche médicale (INSERM), UMRS-1138, Cordeliers research center, Paris, France, 2Pierre and Marie Curie University, Paris, France, 3Paris Descartes university, Paris,
France, 4Anatomy-pathology departments, mutualiste montsouris institute hospital, Paris, France, 5Anatomy, pathology and thoracic surgery department, Hôtel Dieu hospital, Paris, France.
P.A.06.14 Resistance to suppression of CCR6+ T cell migration by regulatory T cells in patients with Psoriatic Arthritis
H. M. Baldwin, A. Ezeonyeji, M. R. Butt, M. R. Ehrenstein;
University College London, London, United Kingdom.
P.A.06.15 In vitro development of functional thymic and splenic regulatory T cells
R. Pap, E. Ugor, L. Prenek, D. Simon, T. Berki;
Department of Immunology and Biotechnology, Faculty of Medicine, University of Pécs, Hungary, Pécs, Hungary.
P.A.06.16 CD161+ regulatory T cells in immune regulation
C. L. Duurland1, T. Brooks2, M. Hubank2, R. F. O’Shaughnessy3, L. R. Wedderburn1;
1
Infection, Inflammation and Rheumatology Section, UCL Insitute of Child Health, London, United Kingdom, 2Centre for Translation Omics, Genetics and Genomics Medicine, UCL Insitute of Child Health,
London, United Kingdom, 3Immunobiology Section, UCL Insitute of Child Health, London, United Kingdom.
P.A.06.17
Mechanisms of pregnancy-induced tolerance in an animal model of multiple sclerosis
J. B. Engler1, M. Piedavent1, S. M. Gold1, P. C. Arck2, M. A. Friese1;
1
Institute of Neuroimmunology and Multiple Sclerosis, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Experimental Feto-Maternal Medicine,
Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
P.A.06.18 Mouse models for skin gene-therapy: In vivo generation of regulatory T-cells for graft protection
S. Kitzmüller1,2, D. Pinheiro1, M. Klicznik1, I. Gratz1,2,3;
1
Department of Molecular Biology, Universtiy Salzburg, Salzburg, Austria, 2Division of Molecular Dermatology and EB House Austria, Department of Dermatology, Paracelsus Medical University, Salzburg,
Austria, 3Department of Dermatology, University of California San Franciso, San Francisco, CA, United States.
Chairpersons: Yvonne Samstag; Heidelberg, Germany / Roland Tschismarov; Vienna, Austria
P.A.07.01
CTLA-4 (CD152) supports tumor progression by preventing plasticity of Tc17 cells
P.A.07.02
High resolution imaging to quantitate the molecular dynamics of antigen recognition by cytolytic T cells
P.A.07.03
Hobit is a transcription factor involved in metabolic regulation and survival of human cytotoxic lymphocytes
A. Arra1, H. Lingel1, J. Pick1, M. Huber2, M. Pierau1, M. Brunner-Weinzierl1;
1
Department of Experimental Pediatrics, Otto-von-Guericke-University, Magdeburg, Germany, 2Institute of Medical Microbiology and Hygiene, University of Marburg, Marburg, Germany.
M. Kraller, R. Platzer, P. Spechtl, H. Stockinger, J. B. Huppa;
F. Vieira Braga1, A. T. Hoekstra2, W. Tigchelaar3, N. Kragten1, R. a. van Lier1, N. N. van der Wel4, C. R. Berkers2, K. P. van Gisbergen1;
1
Sanquin Blood Supply Foundation, Amsterdam, Netherlands, 2Utrecht Medical Centre, Utrecht, Netherlands, 3Amsterdam Medical Centre, Amsterdam, Netherlands, 4Amesterdam Medical Centre,
Amsterdam, Netherlands.
P.A.07.04 Sustained killing by cytotoxic T lymphocytes is shaped by individual heterogeneity in multiple killing performance
L. Dupre1, Z. Vasconcelos2, S. Müller1, D. Guipouy1, Y. Wong3, C. Christophe4, S. Gadat5, S. Valitutti1;
INSERM UMR1043, Toulouse, France, 2Fernandes Figueira Institute, Fiocruz, Rio-de-Janeiro, Brazil, 3Stanford University School of Medicine, Stanford, CA, United States, 4Institut de Mathématiques de
Toulouse, Toulouse, France, 5Toulouse School of Economics, Université de Toulouse I Capitole, Toulouse, France.
1
P.A.07.05
The clinically approved pro-oxidative drug WF-10 inhibits cytotoxicity of primary human CD8+ T-cells
G. Wabnitz, S. Groh, B. Jahraus, H. Kirchgessner, F. Michalke, S. Meuer, Y. Samstag;
University of Heidelberg, Heidelberg, Germany.
P.A.07.06 CNS-infiltrating T cells, from the draining cervical lymph node reservoir, are not essential for viral control in the non-adapted Dengue virus-2 encephalitis mouse
model
L. D. Vu, N. J. King;
University of Sydney, Sydney, Australia.
P.A.07.07
CD8+ T cells express inhibitory receptors but retain functionality in a humanized mouse model of Epstein-Barr virus infection
B. Chatterjee1, D. Vanaoica1, D. Korkmaz1, H. Pircher2, C. Münz1;
1
University of Zürich, Zürich, Switzerland, 2University of Freiburg, Freiburg, Germany.
P.A.07.09 Immunity to the newly emerged A/H7N9 influenza virus
Z. Wang1, S. Quiñones-Parra1, E. Grant1, L. Loh1, Y. Wan2, P. Thomas3, M. Inouye1, P. C. Doherty1,3, J. Xu2, K. Kedzierska1;
1
University of Melbourne, Parkville, Australia, 2Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Shanghai, China, 3St Jude Children’s Research Hospital, Memphis, TN, United
States.
P.A.07.12 T-cell receptor repertoire in blood of patients with acute cellulitis
M. A. Schmid1,2, K. Schrattbauer3, R. Florian1,2, A. Hauser3, W. Krugluger3, B. Volc-Platzer1,2;
1
Department of Dermatology, Donauspital, Vienna, Austria, 2Medical Research Society, Donaustadt, Vienna, Austria, 3Department of Laboratory Medicine, Donauspital, Vienna, Austria.
P.A.07.13
Type I Interferons regulate Eomesodermin expression and the development of unconventional memory CD8+ T cells
P.A.07.14
Sustained glycolytic switch required for rapid effector function of TEMRA CD8 T cells in healthy volunteers and in immune-stimulated patients
P.A.07.15
Endocytosis of lytic granules in cytotoxic T lymphocytes
V. Martinet, S. Tonon, D. Torres, A. Kohler, A. Azouz, M. Nguyen, V. Flamand, O. Leo, S. Goriely;
Institute for Medical Immunology, Gosselies, Belgium.
G. Tilly1,2, M. Yap1,2, M. Giral1,2,3, D. Laplaud1,2,3, S. Brouard1,2,3, C. Pecqueur4, N. Degauque1,2,3;
1
INSERM UMR1064, Nantes, France, 2Université, Nantes, France, 3CHU, Nantes, France, 4INSERM UMR892, Nantes, France.
H. Chang, E. Krause, J. Rettig, V. Pattu;
Saarland University, Homburg, Saar, Germany.
13
P.A.07.16 Development of an in vitro Plasmodium parasite inhibition assay for the evaluation of cell-mediated immune responses following vaccination with preerythrocytic malaria vaccines against Plasmodium falciparum.
C. M. Bliss1, A. J. Spencer1, A. M. Salman1, R. J. Longley1, S. M. Khan2, C. J. Janse2, A. V. Hill1, K. J. Ewer1;
1
Jenner Institute, Oxford, United Kingdom, 2Leiden University Medical Centre, Leiden, Netherlands.
P.A.07.17
Analysis of mutant tumor antigen-specific CD8+ T cells in tumors and periphery by multiplex combinatorial tetramer staining and mass cytometry
M. Fehlings1, H. L. Penny1, M. M. Gubin2, J. P. Ward2, S. C. Wong1, R. D. Schreiber2, E. W. Newell1;
A-Star Singapore Immunology Network (SIgN), Singapore, Singapore, 2Department of Pathology and Immunology, Washington School of Medicine, St. Louis, MO, United States.
1
Monday
P.A.07.18 Multiple sclerosis and kidney allotransplantation induce antigen-experienced CD8 T cells with different metabolic profiles
G. Tilly1,2, M. Yap1,2, M. Giral1,2,3, D. Laplaud1,2,3, S. Brouard1,2,3, C. Pecqueur4, N. Degauque1,2,3;
1
INSERM UMR1064, Nantes, France, 2Université, Nantes, France, 3CHU, Nantes, France, 4INSERM UMR892, Nantes, France.
P.A.07.19 MR1-restricted T cell repertoire diversity engenders variable MR1-antigen recognition
D. I. Godfrey1, N. Gherardin1, A. Keller2, R. Woolley2, J. Le Nours2, D. S. Ritchie3, P. J. Neeson4, R. W. Birkinshaw2, S. B. Eckle1, J. Waddington1, L. Liu5, D. Fairlie5, A. P. Uldrich1, D. G. Pellicci1, J. McCluskey1, J.
Rossjohn2;
1
University of Melbourne, Parkville, Australia, 2Monash University, Clayton, Australia, 3Royal Melbourne Hospital, Parkville, Australia, 4Peter MacCallum Cancer Centre, East Melbourne, Australia,
5
University of Queensland, Brisbane, Australia.
P.A.07.20
Assessing the CTL immunodominance profile of Epstein-Barr virus through cross-presentation by monocyte-derived dendritic cells
P.A.07.21
dendritic cells are recruited to the bone marrow of myeloma patients where they protect tumor plasma cells from CD8+ t cell killing
C. Forrest, A. Hislop, A. Rickinson;
P. Leone1, S. Berardi1, M. Frassanito1, R. Ria1, V. De Re2, S. Cicco1, S. Battaglia1, P. Ditonno3, F. Dammacco1, V. Racanelli1, A. Vacca1;
1
Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy, 22Bio-Proteomics Facility, Department of Translational Research, Centro di Riferimento Oncologico,
National Cancer Institute, Aviano, Italy, Aviano, Italy, 33Hematology Unit, Di Venere Hospital, Bari, Italy, Bari, Italy.
P.A.08 φδ T Cells
Chairpersons: Dieter Kabelitz; Kiel, Germany / Stephanie Gras; Victoria, Australia (tbc)
P.A.08.01 Gamma Delta T cell abnormalities in severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients
S. L. Hardcastle, E. Brenu, S. Johnston, T. Nguyen, T. K. Huth, S. Ramos, D. Staines, S. Marshall-Gradisnik;
Griffith University, Gold Coast, Australia.
P.A.08.02 The molecular bases of δβ T-cell mediated antigen recognition
E. Chabrol1, S. Eckle2, R. Boer3, J. McCluskey2, J. Rossjohn1,4,5, M. Heemskerk3, S. Gras1,4;
1
Monash University, Clayton, Australia, 2Peter Doherty Institute for Infection and Immunity, Parkville, Australia, 3University Medical Center, Leiden, Netherlands, 4Australian Research Council Centre of
Excellence for Advanced Molecular Imaging, Clayton, Austria, 5Institute of Infection and Immunity, Cardiff, United Kingdom.
P.A.08.03 Vγ9Vδ2 TCR-mediated activation by butyrophilin 3 (BTN3) specific agonist antibody 20.1 or by phosphoantigens (PAg) differs in dependence on human
chromosome 6, discriminates between TCR idiotypes and interferes with each other
F. Riano1, L. Starick1, M. M. Karunakaran1, A. S. Fichtner1, V. Kunzmann2, S. Amslinger3, D. Olive4,5,6, G. De Libero7, S. Gu8, E. J. Adams8, T. Herrmann1;
1
Dept. Virology and Immunobiology, University of Würzburg, Würzburg, Germany, 2Medical Clinic and Policlinic II, University of Würzburg, Würzburg, Germany, 3Dept. Organic Chemistry, University of
Regensburg, Würzburg, Germany, 4CRCM, Team Immunity and Cancer, Cancer Immunomonitoring Platform, Inserm, U1068; Institut Paoli-Calmettes, Marseille, France, 5Aix-Marseille Université, UM 105,
Marseille, France, 6Aix-Marseille Université, UM 105; CNRS, UMR7258, F-13009, Marseille, France, 7Experimental Immunology, University of Basel, Basel, Switzerland, 8Department of Biochemistry and
Molecular Biology, University of Chicago, Chicago, IL, United States.
P.A.08.04 Butyrophilin-like (Btnl) genes: conserved regulators of γδ T cells in tissues
A. Jandke1, P. Vantourout2, R. di Marco Barros1, R. Hart1, A. Hayday1,2;
1
The Francis Crick Institute, London, United Kingdom, 2King’s College London, London, United Kingdom.
P.A.08.05 ERK/MAPK and PI3K signalling dictate effector potential during γδ T cell development
N. Sumaria1, C. L. Grandjean1, D. J. Pang1, B. Silva-Santos2,3, D. J. Pennington1;
1
Blizard Institute, Queen Mary University London, Whitechapel, United Kingdom, 2Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal, 3Instituto Gulbenkian
de Ciência, Oeiras, Portugal.
P.A.08.06 Lung γδ T cells mount innate and adaptive immune responses to Bordetella pertussis
A. Misiak, M. Raverdeau, M. M. Wilk, S. C. Edwards, K. H. Mills;
Trinity College Dublin, Dublin, Ireland.
P.A.08.07 A new mouse model to investigate the function of γδ T cells
I. Sandrock, A. Reinhardt, L. Oberdörfer, I. Prinz;
P.A.08.08 Adaptive immune-like γ/δ T lymphocytes share many common features with their α/β T-cell counterparts
A. Lombes1,2, A. Durand1,2, C. Charvet1,2, M. Rivière1,2, N. Bonilla1,2, C. Auffray1,2, B. Lucas1,2, B. Martin1,2;
1
Cochin Institute, CNRS UMR8104, INSERM U1016, Paris, France, 2Paris Descartes University, Paris, France.
P.A.08.10 Sensing of oxidative-stress by gamma-delta TCR through recognition of Annexin A2
R. Marlin1, H. Kaminski2, V. Pitard2, S. Netzer2, C. Khairallah2, A. Lomenech3, A. Pappalardo2, C. Harly2, E. Scotet4, J. Moreau2, B. Faustin2, J. Dechanet-Merville2;
1
CNRS CIRID- Bordeaux University, Bordeaux, France, 2CNRS CIRID - Bordeaux University, Bordeaux, France, 3CGFB- Bordeaux University, Bordeaux, France, 4INSERM CRCNA - Nantes University, Nantes,
France.
P.A.08.11 Tumour-associated CD11b+Gr1+Ly6G+ myeloid cells suppress the effector response of gamma-delta T cells
S. Mensurado1, M. Rei1,2, N. Goncalves-Sousa1, T. Lança1,3, B. Silva-Santos*1, K. Serre*1;
1
Instituto de Medicina Molecular - Universidade de Lisboa, Lisboa, Portugal, 2Current: University of Oxford, Oxford, United Kingdom, 3Current: Netherlands Cancer Institute, Amsterdam, Netherlands.
P.A.08.12 CD28-costimulation in the presence of TGF-ß and IL-15 induces the differentiation of Vδ2 γδ T cells into a T-Helper 9 like phenotype
C. Peters, H. Oberg, D. Wesch, D. Kabelitz;
Institute of Immunology, Kiel, Germany.
P.A.08.13
zoledronic acid boosts gd T cells anti-leukemic activity in children receiving an haplo ab/CD19 depleted graft
I. Airoldi1, A. Bertaina2, A. Petretto1, B. Lucarelli2, A. Zorzoli1, G. Barbarito1, P. Merli2, C. Lavarello1, L. Brescia2, V. Bertaina2, E. Inglese1, G. Milano2, V. Pistoia1, L. Moretta1, F. Locatelli2;
1
Istituto Giannina Gaslini, Genova, Italy, 2Deparment of Pediatric Hematology and Oncology, IRCCS Bambino Gesù Children’s Hospital, Roma, Italy.
P.A.08.14 Generation of non-secreted isoform of IL-4 in human γδ T-cells: Interplay between cell death and epigenetic modification
J. Bhat1, J. Sosna1, E. Quabius1,2, J. Fritsch1, S. Schuetze1, D. Adam1, D. Kabelitz1;
1
Institute of Immunology, Kiel, Germany, 2Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University, Kiel, Germany.
P.A.08.15 TCRgd+ T-LGL cells are effector TCRgd+ T cells with disturbed proliferation and apoptosis
M. J. Kallemeijn1, Y. Sandberg1, A. F. Muggen1, I. L. Wolvers-Tettero1, D. de Ridder2, J. J. van Dongen1, A. W. Langerak1;
1
Erasmus MC, Rotterdam, Netherlands, 2TU Delft, Delft, Netherlands.
P.A.08.16 Combined IL-12/IL-18 supersedes TCR-stimulation for induction of IFN-γ and for a potent antitumoral activity in human γδT cells
C. Welker1, H. Ziegler1, R. Handgretinger1, H. Rammensee2, K. Schilbach1;
Children’s University Hospital Tübingen, Tübingen, Germany, 2Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany.
1
P.A.08.17
TIM3 on γδ T cells is associated with malaria exposure and dysfunctional cells
E. M. Eriksson1,2, L. J. Ioannidis1,2, S. Karl1,2, Q. Y. Tan1, D. P. Poole3,2, L. J. Robinson1,4, A. B. Carmagnac1, I. Betuela4, P. M. Siba4,5, D. S. Hansen1, I. Mueller1, L. Schofield1,5;
1
Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, 2The University of Melbourne, Melbourne, Australia, 3Monash University, Melbourne, Australia, 4Papua New Guinea Institute of
Medical Research, Goroka, Papua New Guinea, 5James Cook University, Townsville, Australia.
P.A.08.18 A phenotypic and functional re-evaluation of human Vδ2(+) T cells across healthy individuals
P. L. Ryan1, N. Sumaria2, N. Izotova2, M. S. Hasan3, L. A. Bergmeier3, D. J. Pennington2;
1
Centre for Adult Oral Health, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, 2Centre for Immunobiology, Blizard
Institute, Barts and The London Medical School, Queen Mary University of London, London, United Kingdom, 3Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Queen Mary University
of London, London, United Kingdom.
14
P.A.08.19 Casein Kinase 2 regulates AKT signaling to promote the survival of normal and leukemic γδ T-cells
S. T. Ribeiro, J. C. Ribot, J. T. Barata, B. Silva-Santos;
Instituto de Medicina Molecular, Lisboa, Portugal.
P.A.08.20 Retinoic acid modulates IL-17 production by γδ T cells to attenuate autoimmune disease
P.A.08.21 CD8αα costimulation to γδT cell receptors involves diverse molecular interactions with ligands that include MHC class I-like molecules
W. Scheper1, S. Hol1, S. Heijhuurs1, G. J. J. Kierkels1, M. Nishimura2, P. Kavathas3, Z. Sebestyen1, J. Kuball1;
Department of Hematology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Surgery, Loyola University Medical Center, Maywood,
IL, United States, 3Departments of Laboratory Medicine and Immunobiology, Yale University School of Medicine, New Haven, CT, United States.
1
P.A.08.22 Phosphoantigen excretion by Plasmodium falciparum infected erythrocytes and gametocytes
C. Liu1, B. Lindberg2, N. Emami2, I. Faye2, I. Parmryd1;
1
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden, 2Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
P.A.08.23
Effect of intradermal BCG vaccination on circulating γδ T cells in a non-human primate model
Monday
M. Raverdeau, K. H. Mills;
Trinity Biomedical Sciences Institute, Dublin, Ireland.
J. R. Fenn1, A. D. White2, A. G. Dalgleish1, S. A. Sharpe2, M. D. Bodman-Smith1;
St. George’s, University of London, London, United Kingdom, 2Public Health England, Salisbury, United Kingdom.
1
P.A.08.24 The role of Hedgehog signaling in γδ T cells
K. Mengrelis, T. Crompton;
Immunobiology section, Institute of Child Health, University College London, London, United Kingdom.
Chairpersons: Rita Carsetti; Rome, Italy / Juergen Wienands; Goettingen, Germany
P.A.09.01 Functional expression of CD137 (4-1BB) on T helper follicular cells
C. Alfaro1, J. I. Echeveste1, M. E. Rodriguez-Ruiz1, J. L. Solorzano1, J. L. Perez-Gracia1, M. A. Idoate1, J. M. Lopez-Picazo1, A. R. Sanchez-Paulete2, S. Labiano2, C. Oñate1, M. A. Aznar2, M. D. Lozano1, I.
Melero1;
1
Clinica Universidad de Navarra, Pamplona, Spain, 2Centro de Investigacion Medica Aplicada, Pamplona, Spain.
P.A.09.02 Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection
C. Su;
Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, China.
P.A.09.03 Impairment of follicular helper and regulatory T cells is associated with skewed B cell maturation in HIV-infected spleens
A. Rouers1, L. Colineau1, T. Yamamoto2, Y. Xu3, A. Urrutia1, H. Pham4, S. Cardinaud1, A. Samri5, K. Dorgham5, P. Coulon1, R. Cheynier6, A. Hosmalin7, E. Oksenhendler8, A. Six4, A. D. Kelleher3, J. Zaunders9, R.
A. Koup2, B. Autran5, A. Moris1, S. Graff-Dubois1;
1
Sorbonne Université, UPMC, UMR1135, CNRS ERL 8255 CIMI-Paris, Paris, France, 2Immunology Laboratory, Vaccine research center, National Institute of Allergy and Infectious Diseases (NIAID), NIH,
Bethesda, MD, United States, 3The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia, 4Sorbonne Universités, UPMC Univ Paris 06, UMRS 959,
Immunology-Immunopathology-Immunotherapy (I3), Paris, France, 5Sorbonne Université, UPMC, UMR1135, CIMI-Paris, AP-HP, Hôpital Pitié Salpêtrière, Department of immunology, Paris, France,
6
INSERM U1016, CNRS UMR8104, Université Paris Descartes, Institut Cochin, Paris, France, 7INSERM U1016, CNRS UMR8104, Université Paris Descartes, Institut Cochin, AP-HP, Hôpital Cochin, Paris,
France, 8Université Paris Diderot, Assistance Publique-Hôpitaux de Paris, Département d’Immunologie Clinique, Hôpital Saint-Louis, Paris, France, Paris, France, 9St. Vincent’s Centre for Applied Medical
Research, St. Vincent’s Hospital, Sydney, Australia.
P.A.09.04 T-cell STAT3 is required for the maintenance of humoral immunity to LCMV
M. Grusdat1, D. R. McIlwain2, K. S. Lang3, P. A. Lang1;
1
Department of Molecular Medicine II, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany, 2Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-University
Düsseldorf, Düsseldorf, Germany, 3Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
P.A.09.05 T follicular helper cell in human NALT and its critical role on CpG-DNA-mediated adjuvant effect on antibody enhancement
A. Aljurayyan1, R. Sharma2, N. Upile2, C. Vaughan2, C. Xie2, H. Beer2, M. McCormick3, P. Achar3, S. Gordon1, Q. Zhang1;
University of Liverpool, Liverpool, United Kingdom, 2Alder Hey Children’s Hospital, Liverpool, United Kingdom, 3Royal Liverpool University Hospital, Liverpool, United Kingdom.
1
P.A.09.06 T follicular helper, but not Th1, cell differentiation in the absence of conventional dendritic cells
M. W. Dahlgren1, T. Gustafsson-Hedberg2, M. Livingston2, H. Cucak1, S. Alsén2, U. Yrlid2, B. Johansson-Lindbom1;
1
Immunology section, Department of Experimental Medical Science, Lund University, Lund, Sweden, 2Department of Microbiology and Immunology, Mucosal Immunobiology and Vaccine Center, Institute of
Biomedicine, University of Gothenburg, Gothenburg, Sweden.
P.A.09.07 Regulation of AID by PARP
S. Tepper1, J. Janzen2, K. Böttcher1, B. Jungnickel1;
1
Department of Cell Biology, Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich-Schiller University, Jena, Germany, 2Institute of Clinical and Molecular Biology, Helmholtz
Center Munich, Munich, Germany.
P.A.09.08 Analysis of vaccine adjuvant effect on B responses at cellular level
H. Vo, D. Piccioli;
GSK Pharmaceutical Company, Siena, Italy.
P.A.09.09 Plasma cell numbers decrease in bone marrow of old patients
A. Meryk1, T. Pritz1, B. Weinberger1, J. Lair2, M. Keller1, M. Ban2, M. Krismer2, B. Grubeck-Loebenstein1;
1
Institute for Biomedical Aging Research, Innsbruck, Austria, 2Department of Orthopedic Surgery, Innsbruck, Austria.
P.A.09.10 The development of pro-inflammatory aglycosylated IgG antibodies is dependent on the pro-inflammatory cytokines IFN-γ and IL-17
S. Eschweiler1, Y. Bartsch1, C. Hess2, M. Ehlers1;
1
Institute for Systemic Inflammation Research, Lübeck, Germany, 2German Rheumatism Research Center, Berlin, Germany.
P.A.09.11 Post-transcriptional mRNA regulation is essential for B cell antibody responses
M. D. Diaz-Munoz1, S. E. Bell1, E. Monzon-Casanova1, K. Fairfax2, A. F. Cunningham3, M. Gonzalez-Porta4, S. Andrews1, V. I. Bunik5, K. Zarnack6, T. Curk7, D. L. Kontoyiannis8, J. Ule9, M. Turner1;
1
The Babraham Institute, Cambridge, United Kingdom, 2Department of Immunology, Central Clinical School, Monash University, Melbourne, Australia, 3MRC Centre for Immune Regulation, Institute
of Microbiology and Infection, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, 4European Molecular Biology Laboratory, European Bioinformatics Institute,
Wellcome Trust Genome Campus, Cambridge, United Kingdom, 5A. N. Belozersky Institute of Physico-Chemical Biology and Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State
University, Moscow, Russian Federation, 6Buchmann Institute for Molecular Life Sciences, Frankfurt, Germany, 7University of Ljubljana, Faculty of Computer and Information Science, Ljubljana, Slovenia,
8
Division of Immunology, Biomedical Sciences Research Center “Alexander Fleming”, Vari, Greece, 9UCL Genetics Institute, Department of Genetics, Environment and Evolution, University College London,
London, United Kingdom.
P.A.09.12 Differential expression of FCRLA in human lymphoid tissues
E. S. Reshetnikova, L. V. Mechetina, A. V. Taranin;
Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russian Federation.
P.A.09.13 Characterization of circulating HIV-specific B cells
A. Rouers1, B. Su2, J. Thevenot1, A. Samri3,4, L. Hocqueloux5, O. Lambotte6, H. Mouquet7, C. Moog2, S. Graff-Dubois1, A. Moris1,4;
1
CIMI-Paris Sorbonne Universités, UPMC Univ Paris 06 UMRS 1135 - INSERM U1135 – CNRS ERL 8255, Paris, France, 2INSERM U1109, Fédération de Médecine Translationnelle de Strasbourg, Université
de Strasbourg, Strasbourg, France, 3CIMI-Paris Sorbonne Universités, UPMC Univ Paris 06 UMRS 1135 - INSERM U1135, Paris, France, 4AP-HP, Hôpital Pitié-Salpêtière, Department of Immunology, Paris,
France, 5COREVIH Centre Poitou-Charentes, CHU Bretonneau, Tours, France Service de Maladies Infectieuses, CHR d’Orléans-La Source, Orléans, France, 6AP-HP, Hôpital de Bicêtre, Service de Médecine
Interne,, Le Kremlin Bicêtre, France, 7Laboratory of Humoral Response to Pathogens, Department of Immunology, Institut Pasteur, CNRS-URA 1961, Paris, France.
P.A.09.14 The role of the Syk/Shp1 kinase-phosphatase equilibrium in B-cell development and signaling
A. Alsadeq1,2, E. Hobeika1,3, D. Medgyesi1,3, K. Kläsener1,3, M. Reth1,3,4;
1
Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany, 2Spemann Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University, Freiburg, Germany, 3Dept. of
Immunolgy, Inst. of Biology III, Faculty of Biology, Albert Ludwigs University, Freiburg, Germany, 4BIOSS Centre for Biological Signalling Studies, Albert Ludwigs University, Freiburg, Germany.
P.A.09.15 Elucidation of IgH 3’ region regulatory role during B cell development via germline deletion
A. Saintamand1,2, P. Rouaud1,2, A. Garot1,2, M. Cogné1,2,3, Y. Denizot1,2;
1
Université de Limoges, Limoges, France, 2CNRS UMR 7276, Limoges, France, 3Institut Universitaire de France, Paris, France.
15
P.A.09.16 Survival of human circulating antigen-induced plasma cells is supported by plasma cell-niche cytokines and Tfh lymphocytes
A. Campos-Caro1, A. B. Ramos-Amaya1, B. Rodríguez-Bayona1, R. López-Blanco1, E. Andújar2, M. Pérez-Alegre2, J. A. Brieva1;
1
Hospital Universitario Puerta del Mar, Cádiz, Spain, 2Unidad de Genómica, Centro Andaluz de Biología Molecular y Medicina Regenerativa and CSIC, Seville, Spain.
P.A.09.17
VprBP’s serine/threonine kinase activity supports V(D)J recombination by promoting expression of RAG1/2
N. M. Schabla, G. A. Perry, J. T. Fletcher, P. C. Swanson;
Creighton University, Omaha, NE, United States.
Monday
P.A.10 B Cells in Autoimmunity and Tolerance
Chairpersons: Lars Nitschke; Erlangen, Germany / Andrey I. Tchorbanov; Sofia, Bulgaria
P.A.10.01
Repertoire of anti-ADAMTS13 specific B-cells from the spleen of acquired Thrombotic Thrombocytopenic Purpura (aTTP) patients
P.A.10.02
Lung B cells promote ongoing allergic inflammation in a mouse model of asthma via B cell receptor-independent antigen presentation
P.A.10.03
Myelin basic protein-induced production of tumor necrosis factor-α and interleukin-6, and presentation of the immunodominant peptide MBP85-99 by B cells
from patients with multiple sclerosis
M. Skowronska, M. Schaller, J. A. Kremer Hovinga;
University Hospital Bern, Inselspital, Bern, Switzerland.
T. Wypych1,2, L. Perez1, A. Lanzavecchia1,3, F. Sallusto1;
1
Institute for Research in Biomedicine, Università della Svizzera Italiana (USI), Bellinzona, Switzerland, 2Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland, 3ETH
Zurich, Zurich, Switzerland.
M. K. Brimnes1, L. Börnsen2, F. Sellebjerg2, C. H. Nielsen1;
1
Institute for Inflammation Research, Department of Infectious Diseases and Rheumatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, 2Department of Neurology,
Copenhagen University Hospital Rigshospitalet, Danish Multiple Sclerosis Center, Copenhagen, Denmark.
P.A.10.04 Siglec-G: a B cell inhibitory receptor controlling autoimmunity
J. Müller1, S. Bökers1, S. Hutzler1, L. Özgör1, H. Jumaa2, K. Kläsener3, M. Reth3, L. Nitschke1;
1
University of Erlangen, Erlangen, Germany, 2University of Ulm, Ulm, Germany, 3University of Freiburg, Freiburg, Germany.
P.A.10.05
Bias in peripheral B lymphocyte subpopulations potentiate fibroblast activation in systemic sclerosis
N. Dumoitier1,2, S. Lofek1, A. Régent3, J. London3, B. Chaigne1,3, B. Terrier1,3, N. Varin-Blank2,4, L. Mouthon1,2,3;
1
Institut Cochin INSERM U1016, Paris, France, 2Labex Inflamex, Paris, France, 3Service de Médecine Interne de l’hôpital Cochin, Paris, France, 4INSERM, UMR978, UFR SMBH, Bobigny, France.
P.A.10.06 Altered TIM-1 expression and regulatory B cells functions in systemic sclerosis patients
O. A. Aravena-Madariaga1, A. Ferrier1, J. Aguillon1, L. Soto1,2, D. Catalan1;
1
Programa Disciplinario de Inmunologia, Facultad de Medicina, Universidad de Chile, Santiago, Chile, 2Hospital Clínico, Universidad de Chile, Santiago, Chile.
P.A.10.08 B-lineage cells suppress osteoclastogenesis through the production of interleukin-10
L. Meng1, J. Luther2, C. Link1, B. Frehse1, K. Hofmann1, A. Albeidaq1, D. Jean-Pierre2, R. Manz1;
1
Institute for Systemic Inflammation Research, Luebeck, Germany, 2Institute for Osteology and Biomechanics, Hamburg, Germany.
P.A.10.09 Population specific IL-10 production of mouse B cells induced by the BCR, TLR9 or CD40
K. Huber, G. Sarmay, D. Kovesdi;
Eotvos Lorand University, Budapest, Hungary.
P.A.10.10
Rheumatoid Arthritis patients possess a reduced ratio between regulatory and effector B cells as compared to healthy controls
P.A.10.11
Differential expression of chemokine receptors CXCR4 and CXCR5 on peripheral blood B cells from patients with early arthritis who progressed to rheumatoid
arthritis
Z. Bankó1, P. Judit1, N. György2, G. Tamás2, R. Bernadette2, S. Gabriella1;
1
Department of Immunology, Eotvos Lorand University, Budapest, Hungary, 2Department of Rheumatology, Polyclinic of the Hospitaller Brothers of St. John of God, Budapest, Hungary.
I. Henc1, E. Brzustewicz1, A. Daca1, M. Szarecka2, M. Sochocka-Bykowska2, E. Bryl1;
1
Medical University of Gdansk, Gdańsk, Poland, 2Voivodal Rheumatology Hospital, Sopot, Poland.
P.A.10.12
Complement receptor type 1 (CD35) inhibits TLR9-mediated B cell functions - a novel cross-talk between comlement, TLRs and adaptive immunity in physiological
and autoimmune conditions
M. Kremlitzka1, B. Mácsik-Valent2, A. Polgár3, E. Kiss3, G. Poór3, A. Erdei1,2;
1
MTA-ELTE Immunology Research Group, Budapest, Hungary, 2Eötvös Loránd University, Budapest, Hungary, 3Institute of Rheumatology and Physiotherapy, Budapest, Hungary.
P.A.10.13
Nodal marginal-zone B cells in mice; a distinct virgin and memory subset with latent self-reactivity
P.A.10.14
NFATc1 exaggerates imiquimod-induced skin inflammation by inhibiting IL-10 expression in B cells
P.A.10.15
Longterm Memory Plasma Cell Depletion: the need of a combined depletion of Plasma Cells and Their Precurors in NZB/W Mice
A. E. Palm, H. C. Friedrich, S. Kleinau;
Uppsala University, Uppsala, Sweden.
H. Alrefai1, A. Kerstan2, R. Rudolf1, K. Muhammad1, M. Goebeler2, E. Serfling1;
1
Institute of Pathology, Mol. Pathology, Wuerzburg, Germany, 2Univ. Hospital, Department of Dermatology, Venereology and Allergiology, Wuerzburg, Germany.
A. Taddeo1, L. Khodadadi2, Q. Cheng2, A. Radbruch1, F. Hiepe2, B. F. Hoyer2;
1
German Rheumatism Research Center, Berlin, Germany, 2Charité University Hospital Berlin, Berlin, Germany.
P.A.10.16 IL-4-treated mast cells activate regulatory B cells
F. Marsh-Wakefield1,2, C. O’Sullivan2, S. Leighton2, C. Gillis1,2, G. M. Halliday2, S. N. Byrne1,2;
1
Cellular Photoimmunology Group, Infectious Diseases and Immunology, University of Sydney, Sydney, Australia, 2Dermatology Research Laboratories, University of Sydney, Sydney, Australia.
P.A.10.17
Identification of an antigen-specific regulatory B Cell subset in humans
L. Le Pottier, J. Pers;
University, Brest, France.
P.A.10.18 IL-10 Producing Regulatory B cells Are Decreased in Patients with Myasthenia Gravis
J. Sheng;
Univ of Chicago, Chicago, IL, United States.
P.A.10.19 Generation and investigation of mice with overexpressed CD22 and Siglec-G proteins
H. Seifried, L. Nitschke;
Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
P.A.10.20
Production of anti-DNAds and anti-extractable nuclear antigens (ENA) autoantibodies by circulating plasmablasts/plasma cells and auto-reactive B-cells in SLE
patients
R. de la Varga Martínez1, B. Rodríguez-Bayona2, G. A. Añez3, F. Medina3, J. J. Pérez-Venegas4, C. Rodríguez1;
1
Immunology Department. Hospital Universitario Puerta del Mar, Cádiz, Spain, 2Biochemistry Department. Hospital Universitario Puerta del Mar, Cádiz, Spain, 3Rheumatology Department. Hospital
Universitario Puerta del Mar, Cádiz, Spain, 4Rheumatology Department. Hospital Universitario de Jerez, Cádiz, Spain.
16
P.A.10.21
Abnormalities of memory B cell subsets in systemic sclerosis
P.A.10.22
CD200R expression is influenced by stimulation but is not abnormal in the chronic inflammatory settings of Reumatoid Arthritis
P.A.10.23
Clinical parameters and B cell subsets as biomarkers of response to tocilizumab in Rheumatoid Arthritis
A. Bognár1, D. Simon1, P. Balogh1, T. Minier2, L. Czirják2, T. Berki1;
1
Department of Immunology and Biotechnology, University of Pécs, Pécs, Hungary, 2Department of Rheumatology and Immunology, Clinic Center, University of Pécs, Pécs, Hungary.
A. L. Lemarquis1, B. R. Ludvikson1, R. E. Toes2, H. U. Scherer3;
1
University Hospital of Iceland, Reykjavík, Iceland, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Department of Rheumatology at Leiden University Medical
Center, Leiden, Netherlands.
B. Tolusso, A. Fedele, E. Gremese, S. Canestri, C. Di Mario, G. Ferraccioli;
Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy.
P.B.01.01
3D coculture of Staphylococcus aureus and phagocytes in nanofibrous scaffold
P.B.01.02
Macrophages subvert immune responses to uropathgenic E. coli during urinary tract infection
P.B.01.03
Lymphocyte apoptosis and CD44 expression during inflammatory response of bovine mammary gland induced by lipopolysaccharide
P.B.01.04
Klebsiella pneumoniae blocks autophagy
P.B.01.05
Bartonella species - another tick-borne pathogen?
P.B.01.06
A newly established real-time PCR for detection of Borrelia miyamotoi in Ixodes ricinus ticks
P.B.01.07
Characterization of splenic microarchitecture during chronic infection by wild type and mutant strains of Brucella melitensis in mouse experimental model
C. Kim1,2, T. Kim1,3, H. Bae3, P. Slama4, J. Kwak1,2;
1
Immune-network Pioneer Research Center, Ajou University Medical Center, Suwon 443-380, Korea, Republic of, 2Department of Pharmacology, School of Medicine Ajou University, Suwon 443-380, Korea,
Republic of, 3Department of Physiology, College of Medicine, Dong-A University, Busan 602-714, Korea, Republic of, 4Department of Animal Morphology, Physiology and Genetics, Mendel University in
Brno, 613 00 Brno, Czech Republic.
G. Mora-Bau1,2, A. M. Platt3, N. van Rooijen4, G. J. Randolph5, M. L. Albert1,2, M. A. Ingersoll1,2;
1
Institut Pasteur, Paris, France, 2INSERM U818, Paris, France, 3Mount Sinai School of Medicine, New York, NY, United States, 4Free University Medical Center, Amsterdam, Netherlands, 5Washington
University School of Medicine, St. Louis, MO, United States.
Monday
Chairpersons: Sylvia Knapp; Vienna, Austria / Hanna Jarva; Helsinki, Finland (tbc)
P. Slama1, Z. Sladek1, E. Kabourkova1, Z. Havlicek1, A. Watanabe2, J. Y. Kwak3;
1
Mendel University in Brno, Brno, Czech Republic, 2National Institute of Animal Health, Sapporo, Japan, 3Ajou University, Suwon, Korea, Republic of.
S. Yoba, J. Bengoechea;
Centre for Infection and Immunity, Queen’s University Belfast, Belfast, United Kingdom.
A. Müller, M. Reiter, H. Stockinger, G. Stanek;
Institute for Hygiene and Applied Immunology, Vienna, Austria.
M. Reiter, A. Schötta, A. Müller, H. Stockinger, G. Stanek;
Institut für Hygiene und Angewandte Immunologie, Vienna, Austria.
K. Abir1, A. Machelart1, J. Letesson1, E. Muraille2;
1
Namur university, namur, Belgium, 2Université libre de Bruxelles, Bruxelles, Belgium.
P.B.01.08 Evaluation of immunologically factors involved in initiation of chronic brucellosis in CD4+ T cells using mRNA array
F. Budak1, H. Bal1, G. Tezcan2, H. Akalın3, G. Goral1, H. B. Oral1;
1
Uludag University, Faculty of Medicine, Immunology Department, Bursa, Turkey, 2Uludag University, Faculty of Medicine, Medical Biology Department, Bursa, Turkey, 3Uludag University, Faculty of
Medicine, Clinical Microbiology and Infection Diseases Department, Bursa, Turkey.
P.B.01.09
Evaluation of immunologically factors iınvolved in initiation of chronic brucellosis in CD8+ T cells using mRNA array
P.B.01.10
Evaluation of immunologically factors involved in initiation of chronic brucellosis in peripheral blood mononuclear cells using mRNA array
P.B.01.12
Protection in ocular chlamydial infection is dependent on infectious dose of Chlamydia caviae in guinea pig inclusion conjunctivitis model
P.B.01.13
IkBNS deficient mice are protected against high-dose Listeria monocytogenes infection
P.B.01.14
A functional STAT4 variant increases the risk of nontyphoidal Salmonella bacteraemia in African children
P.B.01.16
Elucidating the host cell response to Chlamydia trachomatis infection: the role of guanylate binding proteins
P.B.01.17
The role of tyrosine kinase 2 in the immune response during bacterially induced sepsis
P.B.01.18
Leptospirosis. The experience of a tertiary hospital in a region of Western Greece during a period of fifteen years
1
1
S. Belij-Rammerstorfer1, A. Inic-Kanada1, M. Stojanovic2, E. Marinkovic2, I. Lukic2, E. Stein1, J. Montanaro1, N. Bintner1, N. Schürer1, M. Kundi3, T. Barisani-Asenbauer1;
1
OCUVAC – Center of Ocular Inflammation and Infection; Medical University of Vienna, Vienna, Austria, 2Department of Research and Development; Institute of Virology, Vaccines and Sera – Torlak,
Belgrade, Serbia, 3Institute of Environmental Health, Center for Public Health, Medical University of Vienna, Vienna, Austria.
S. Frentzel1, A. Jeron1, I. Schmitz2, D. Bruder1,3;
1
Institute of Medical Microbiology and Hospital Hygiene,University Hospital, Magdeburg, Germany, 2Systems-oriented Immunology and Inflammation Research, Helmholtz Centre for Infection Research,
Braunschweig, Germany, 3Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.
J. J. Gilchrist1, T. C. Mills1, V. Naranbhai1, S. J. Chapman1, B. P. Fairfax1, J. C. Knight1, Wellcome Trust Case Control Consortium 2, T. N. Williams2, J. A. Scott2, C. A. MacLennan3, A. L. Rautanen1, A. V. Hill1;
1
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, 2KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya, 3Wellcome Trust Sanger Institute, Hinxton, United
Kingdom.
V. Lindenberg1, K. Mölleken2, E. Kravets1, D. Degrandi1, J. Hegemann2, K. Pfeffer1;
1
Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University, Düsseldorf, Germany, 2Institute for Functional Genome Research of Microorganisms, Heinrich-Heine-University,
Düsseldorf, Germany.
K. Ben Mahfoudh1, R. Rom1, M. Biaggio1, C. Lassnig1,2, A. Puga1, S. Knapp3, M. Mueller1,2, B. Strobl1;
1
Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria, 2Biomodels Austria, University of Veterinary Medicine, Vienna, Austria, 3CeMM-Research Center for Molecular
Medicine of the Austrian Academy of Sciences, Department of Medicine I, Laboratory of Infection Biology, Medical University, Vienna, Austria.
N. Zotos1, T. Potsis2, M. Gianniki3, D. Bougias3, A. Papadopoulou1, C. Georgiou1, L. Papageorgiou1, E. Chrisostomou1, A. Pournou1, N. Tsifetaki3;
Microbiology Department, General Hospital of Ioannina “G.Hatzikosta”, Ioannina, Greece, 2Private Cardiology Office, Ioannina, Greece, 3Department of Rheumatology, General Hospital of Ioannina
“G.Hatzikosta”, Ioannina, Greece.
1
P.B.01.19
luxCDABE reporter system-based monitoring of lipopolysaccharide outer core and O-antigen expression in Yersinia enterocolitica O:3 during mouse infection
P.B.01.20
Immunological essentials for the diagnosis of Lyme borreliosis
P.B.01.21
Immunomodulatory effects of chicken cathelicidin CATH-2
P.B.01.22
Polarization of human macrophages in vitro favors survival of the intracellular pathogen Chlamydia pneumoniae
P.B.01.23
Trimming IL-1 signaling for protection against Streptococcus pyogenes
E. Bozcal1, M. Dagdeviren2, A. Uzel3, M. Skurnik4;
1
Istanbul University,Faculty of Science, Biology Department,Basic and Industrial Microbiology Section and Ege University, Faculty of Science, Biology Department, Basic and Industrial Microbiology
Section, Istanbul, Izmir, Turkey, 2Ege University, Faculty of Science, Biology Department, General Biology Section, Izmir, Turkey, 3Ege University, Faculty of Science, Biology Deaprtment, Basic and Industrial
Microbiology Section, Izmir, Turkey, 4Haartman Institute, Department of Bacteriology and Immunology, Research Programs Unit, Immunobiology, University of Helsinki and Helsinki University Central
Hospital Laboratory Diagnostics, Helsinki, Finland.
G. Stanek1, M. Markowicz1, D. Stupica2, F. Strle2;
1
Institute for Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria, 2University Medical Center, Ljubljana, Slovenia.
M. D. Kraaij, A. van Dijk, H. P. Haagsman;
Utrecht University, Utrecht, Netherlands.
T. Buchacher1, A. Ohradanova-Repic2, H. Stockinger2, M. B. Fischer1,3, V. Weber1;
1
Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis, Department for Health Sciences and Biomedicine, Danube University Krems, Krems, Austria, 2Molecular Immunology Unit,
Institute for Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria, 3Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
M. Janos, F. Sonego, V. Castiglia, P. Kovarik;
Max F. Perutz Laboratories / Universität Wien, Vienna, Austria.
17
Chairpersons: Christian Münz; Zurich, Switzerland / Ger van Zandbergen; Langen, Germany
Monday
P.B.02.01
Persisting IgM antibodies against Borrelia burgdorferi sensu lato: over-interpretation or cross-reactivity?
P.B.02.02
Highly specific monoclonal antibodies against Methicillin-resistant Staphylococcus aureus (MRSA)
P.B.02.03
Human MAIT cell immune surveillance at bile ducts in the portal tract
P.B.02.04
Phagocytosis and intracellular reactive oxygen species production by milk polymorphonuclear leukocytes in dairy cows with high and low somatic cell count
P.B.02.05
The role of elastase in antimicrobial action against Moraxella catarrhalis
P.B.02.06
Rickettsia typhi induces neutrophilia and neutrophil-mediated liver pathology
P.B.02.07
Rickettsia typhi persists in mice and can cause fatal CNS inflammation
P.B.02.08
Protective role of CD8+ and CD4+ T cells in Rickettsia typhi infection
P.B.02.09
Staphylococcus aureus toxins PSMα induce a delay in host cell mitotic process, which correlates with a decrease of antibacterial functions of epithelial cells
M. Markowicz, H. Stockinger, G. Stanek;
Institute for Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria.
N. Maier1, S. Arnold2, M. Listek1, M. Nickisch-Rosenegk2, F. Bier2, K. Hanack1;
1
University of Potsdam, Potsdam, Germany, 2Fraunhofer Institute for Cell Therapy and Immunology IZI, Bioanalytics and Bioprocesses branch, Potsdam, Germany.
H. C. Jeffery1, B. van Wilgenburg2, K. Stirling1, K. Parekh1, S. Roberts1, A. Kurioka2, S. Hunter1, J. Rajanayagam1, T. Iqbal3, R. Brown3, D. H. Adams1,3, P. Klenerman2, Y. H. Oo1,3;
1
Centre for Liver Research and NIHR BRU in Liver Disease, University of Birmingham, Birmingham, United Kingdom, 2Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United
Kingdom, 3University Hospital of Birmingham, Birmingham, United Kingdom.
M. G. Blagitz1, F. N. Souza2, C. F. Batista1, L. F. Azevedo1, N. R. Benites1, P. A. Melville1, A. M. Della Libera1;
1
Faculdade de Medicina Veterinária e Zootecnia - Universidade de São Paulo, São Paulo, Brazil, 2Escola de Veterinária - Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
J. Roszkowiak1, J. Nowak2, D. Augustyniak1;
1
Department of Pathogen Biology and Immunology, University of Wroclaw, Wroclaw, Poland, 2Department of Human Biology, University of Wroclaw, Wroclaw, Poland.
S. Papp1, U. Richardt1, S. Kuehl1, B. Fleischer1,2, A. Osterloh1;
1
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, 2Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
A. Osterloh1, S. Papp1, K. Moderzynski1, S. Kuehl1, B. Fleischer1,2;
1
Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany, 2Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
K. Moderzynski1, B. Fleischer1,2, A. Osterloh1;
1
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, 2Institute of Immunology, University Medical Center Hamburg - Eppendorf, Hamburg, Germany.
M. Deplanche1, R. El-Aouar Filho2, L. Alekseeva3, E. Ladier1, J. Jardin1, G. Henry1, V. Azevedo4, F. Laurent5, G. Gerard Lina5, F. Vandenesch5, Y. Le Loir1, M. Otto6, F. Götz7, N. Berkova1;
INRA, Agrocampus Ouest, Rennes, France, 2INRA, Agrocampus Ouest, Universidade Federal de Minas Gerais, Belo Horizonte-MG, Brazil, 3INRA, Agrocampus Ouest, Shemyakin-Ovchinnikov Institute of
Bioorganic Chemistry, Moscow, Russian Federation, 4Universidade Federal de Minas Gerais, Belo Horizonte-MG, Brazil, 5CNR, INSERM U1111, Université Lyon, Lyon, France, 6US National Institutes of
Health, Bethesda, MD, United States, 7University of Tübingen, Tübingen, Germany.
1
P.B.02.10
Differences in adherence and internalization capacity into bovine mammary epithelial cells among bovine associated staphylococci
P.B.02.12
A20 deficiency in T cells enhances host immune response to bacterial infection
P.B.02.13
Evaluation of widal tube dilution and Enzyme-Linked Immunosorbent Assay for diagnosing typhoid fever at a referral hospital in Kenya
P.B.02.14
Vimentin may mediate apoptosis of E.coli K1-infected HBMECs
P.B.02.15
Astrocyte-derived MMP-9 impairs blood-brain barrier functions in central nervous system tuberculosis
P.B.02.16
Development of a diagnostic assay for the detection of Mycobacterium bovis infection in the African lion (Panthera leo)
P.B.02.17
The role of gene polymorphism and level of anti-inflammatory cytokines in blood at patients with pulmonary tuberculosis
P.B.02.18
Human primary CD1c + DCs revealed a superior responsiveness and plasticity in response to mycobacteria infection
P.B.02.19
Vıtamın D Levels In Leprosy Patıents
P.B.02.20
Genes affecting host response against mycobacteria in zebrafish (Danio rerio)
P.B.02.21
Shift of the immune responses toward TH2 in Chronic Brucellosis
P.B.02.22
A naturally occuring inactivation of a major transcription factor elicits bacterial immune subversion
F. N. Souza1, S. Piepers2, K. Piccart2, A. M. Della Libera3, M. B. Heinemann4, M. O. Cerqueira1, S. De Vliegher2;
1
Escola de Veterinária - Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, 2M-team and Mastitis and Milk Quality Research Unit, Department of Reproduction, Obstetrics and Herd Health,
Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium, 3Departamento de Clínica Médica - Faculdade de Medicina Veterinária e Zootecnia -Universidade de São Paulo, São Paulo, Brazil,
4
Departamento de Medicina Veterinária Preventiva e Saúde Animal - Faculdade de Medicina Veterinária e Zootecnia -Universidade de São Paulo, São Paulo, Brazil.
S. Just1, G. Nishanth1, M. Naumann2, D. Schlüter1;
1
Institute of Medical Microbiology, Magdeburg, Germany, 2Institute of Experimental Internal Medicine, Magdeburg, Germany.
A. J. Buigut1, R. K. Biegon1, W. K. Aruasa2, K. Patel1, N. G. Buziba1, S. K. Mining3;
1
Moi University, College of Health Sciences, School of Medicine, Department of Immunology, Eldoret, Kenya, 2Moi Teaching and Referral Hospital, Department of Clinical Services, Eldoret, Kenya, 3Moi
University, College of Health Sciences, School of Medicine, Department of Immunology and Department of Research, Eldoret, Kenya.
X. He1, B. Zhang2, Q. Zeng1, M. Long1, H. Cao1;
1
Dept. of Microbiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China, 2School of Public Health and Tropical Medicine, Southern Medical University,
Guangzhou, China.
S. Brilha1, C. W. Ong2, J. S. Friedland1;
1
Imperial College London, London, United Kingdom, 2National University Health System, Singapore, Singapore.
T. T. Olivier1, J. Hofmeyer2, W. Goosen1, I. Viljoen1, A. Tordiffe3, P. Buss2, R. Warren1, P. van Helden1, M. Miller1, S. Parsons1;
1
Stellenbosch University, Cape Town, South Africa, 2Veterinary Wildlife Services, Kruger National Park, Skukuza, South Africa, 3National Zoological Gardens of South Africa, Pretoria, South Africa.
D. O. Butov1, M. Kuzhko2, T. Butova1, M. Pitenko1, O. Pionova1;
1
Kharkiv National Medical University, Kharkiv, Ukraine, 2F.G. Yanovsky National Institute of Phtysiatry & Pulmonology, National Academy of Medical Sciences, Kiev, Ukraine.
M. Bechtle, J. Weiner, S. Kaufmann, L. Lozza;
Max Planck Institute for Infection Biology, Berlin, Germany.
N. Isiksacan1, M. Bicer1, M. Koser2;
1
Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey, 2Mehmet Akif Ersoy Cardiology and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
M. J. Ojanen1, S. Harjula1, K. Oksanen1, H. Myllymäki1, C. A. Bäuerlein1, M. Rämet1,2,3;
1
BioMediTech, University of Tampere, Tampere, Finland, 2Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland, 3PEDEGO Research Unit, Medical Research Center Oulu,
University of Oulu, Oulu, Finland.
G. Mosayebi, K. Khosravi, N. Zarinfar, E. Ghaznavi- Rad;
School of Medicine, Arak, Iran, Islamic Republic of.
C. Lindemann1, B. Young1, J. Muller1, N. Ternette1, E. Allen1, A. Flaxman1, Y. Yamaguchi1, P. van Diemen1, D. Crook1, R. Massey2, D. J. Wilson1, D. H. Wyllie1;
1
University of Oxford, Oxford, United Kingdom, 2University of Bath, Bath, United Kingdom.
P.B.03 Immunity to Fungi, Helminths and Malaria
Chairpersons: Tracey Lamb; Atlanta, United States / Marita Troye-Blomberg; Stockholm, Sweden
18
P.B.03.01
HLA-II epitope prediction for the Candida albicans proteome revealed important aspects of adaptive anticandidal immunity
P.B.03.02
B cells and antibodies in protective immunity to Candida albicans infection
M. Manczinger1,2, V. Bodnár1, L. Lakatos1,2, L. Kemény1,2;
1
Department of Dermatology and Allergology, Szeged, Hungary, 2MTA-SZTE Dermatological Research Group, Szeged, Hungary.
M. Ferreira-Gomes1, B. Hebecker2, I. D. Jacobsen2, B. Jungnickel1;
1
Department of Cell Biology, Friedrich Schiller University, Jena, Germany, 2Research Group Microbial Immunology, Hans-Knöll-Institute, Jena, Germany.
P.B.03.03
Synthetically prepared nonaglucosaccharide as model inducer of anti-Candida albicans immune response
E. Paulovičová1, L. Paulovičová1, R. Pilišiová1, V. Galliková2, D. V. Yashunsky3, A. A. Karelin3, Y. E. Tsvetkov3, N. E. Nifantiev3;
Department of Immunochemistry of Glycoconjugates, Center for Glycomics, Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia, 2Department of Biochemistry and Microbiology,
Institute of Biochemistry, Nutrition and Health Protection, Faculty of Chemical and Food Technology,Slovak University of Technology in Bratislava, Bratislava, Slovakia, 3N.D. Zelinsky Institute of Organic
Chemistry, Laboratory of Glycoconjugate Chemistry, Russian Academy of Sciences, Moscow, Russian Federation.
P.B.03.04
Eosinophilia, nasal polyps and chronic necrotizing pulmonary aspergillosis with a positive laboratory marker for pulmonary sarciodosis: what came first?
P.B.03.05
Identification of whole pathogenic cells by monoclonal antibodies generated against specific peptide
P.B.03.06
In vivo low-power laser irradiation activates neutrophils and increases their fungicidal activity in first and second encounter with Paracoccidioides brasiliensis;
influence of fungal virulence
M. Stojanovic1, S. Raskovic1,2, J. Bolpacic1,2, A. Bogdanovic3,2, S. Raljevic4,2, I. Djuric-Filipovic5, M. Stankovic2, M. Bogic1,2;
1
Clinic of Allergy and Clinical Immunology, Clinical Center of Serbia, Belgrade, Serbia, 2Faculty of Medicine, University of Belgrade, Belgrade, Serbia, 3Clinic of Haematology, Clinical Center of Serbia,
Belgrade, Serbia, 4Clinic of Pulmology, Clinical Center of Serbia, Belgrade, Serbia, 5Faculty of Medical Science, University of Kragujevac, Kragujevac, Serbia.
N. Maier1, M. Listek1, H. Kaba2, N. Schliebe1, U. Bilitewski2, K. Hanack1;
1
University of Potsdam, Potsdam, Germany, 2Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.
Monday
1
E. Burger1, A. C. Mendes1, G. M. Bani1, A. C. Pereira1, Z. P. Camargo2, L. M. Verinaud3, F. F. Sperandio1;
1
Universidade Federal de Alfenas, Alfenas, Brazil, 2Universidade Federal de São Paulo, São Paulo, Brazil, 3Universidade Estadual de Campinas, Campinas, Brazil.
P.B.03.07
IDO controls the differentiation and function of dendritic cells in the Paracoccidioidomycosis (PCM) of susceptible (B10.A) and resistant (A/J) mice to
Paracoccidioides brasiliensis infection
E. F. Araújo, V. L. Calich, S. B. Bazan, F. V. Loures, C. Feriotti;
USP - University of São Paulo, São Paulo, Brazil.
P.B.03.08
Hyperreactive Onchocerciasis is Characterized by an Antigen Independent Bias towards Th17 Combined with Strong Th2 Immune Responses
T. Adjobimey1, G. Katawa2, L. E. Layland1, A. Y. Debrah3, C. von Horn1, A. Kwarteng1, S. Specht1, D. W. Taylor4, A. Hoerauf1;
Institute for Medical Microbiology, Immunology and Parasitology, Bonn, Germany, 2University of Lomé, Lomé, Togo, 3Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana,
Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
1
4
P.B.03.09
Investigating the immune regulatory properties of Necator americanus on human dendritic cells and keratinocytes
P.B.03.10
Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulusinfected individuals
A. Hassan, A. M. Ghaemmaghami, D. I. Pritchard;
University of Nottingham, Nottingham, United Kingdom.
L. E. Layland1, K. Arndts1, U. Klarmann-Schulz1, L. Batsa2, A. Debrah3, C. Epp4, R. Fimmers5, S. Specht1, A. Hoerauf1;
1
Inst. Med. Microbiol., Immunol., & Parasitology (IMMIP), Bonn, Germany, 2Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR),, Kumasi, Ghana, 3Kumasi Centre for Collaborative
Research in Tropical Medicine (KCCR), Kumasi, Ghana, 4Centre for Infectious Diseases - Parasitology, University Hospital Heidelberg, Heidelberg, Germany, 5Institute of Medical Biometry, Informatics and
Epidemiology (IMBIE), Bonn, Germany.
P.B.03.11
Analysis of the vaccine-induced immunity against gastrointestinal parasites suggests a crucial role for mucosal IgG1 and memory NK cell responses
P.B.03.12
Effect of antihelminthic treatment on vaccine immunogenicity in Gabonese primary school children
P.B.03.13
Malaria induced CTLA-4+Foxp3- T cells inhibit T effector cell function in trans
P.B.03.14
CD8a+ dendritic cells in the pathogenesis of experimental cerebral malaria
A. González-Hernández, S. Van Coppernolle, I. Peelaers, E. Claerebout, P. Geldhof;
Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
S. Brückner1,2, S. Agnandji2, S. Berberich2, B. Abossolo2, E. Bache2, J. Fernandes2, B. Schweiger3, M. Massinga Loembe2, J. Elias4, A. Adegnika1,2, P. Kremsner1,2, M. Esen1,2;
1
Institute of Tropical Medicine, Tübingen, Germany, 2Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon, 3Nationales Referenzzentrum Robert-Koch-Institut, Berlin, Germany,
4
Institute for Hygiene and Microbiology/ NRZM, Würzburg, Germany.
C. Steeg, T. Jacobs;
Bernhard-Nocht-Institute for Tropical Medicin, Hamburg, Germany.
J. M. Kuepper1, M. Borsche1, P. J. Korir1, A. Hoerauf1, I. R. Dunay2, B. Schumak1;
Institute for Medical Microbiology, Immunology and Parasitology, University Hospital, Bonn, Germany, 2Institute of Medical Microbiology, University Hospital, Magdeburg, Germany.
1
P.B.03.15
Acute gammaherpesvirus co-infection suppresses anti-malarial humoral immune responses and can transform a non-lethal Plasmodium infection into a lethal one
P.B.03.16
Monocyte and neutrophil-derived CXCL10 impairs efficient control of blood-stage malaria infection and promotes severe disease
P.B.03.17
Type I interferons signalling on macrophages is involved in the immunopathology of experimental cerebral malaria
P.B.03.18
Studies on immunogenicity and antigenicity of baculovirus-expressed binding region of Plasmodium falciparum EBA-140 merozoite ligand.
P.B.03.19
Myeloid cells act as major host defense against Aspergillus fumigatus lung infections in immunocompromised conditions
P.B.03.20
The role of innate IL-17-producing cells in antifungal immunity
P.B.03.21
Calcineurin inhibitors facilitate opportunistic peritoneal fungal infections via blockage of Ccl2/Ccr2-dependent recruitment of inflammatory monocytes
P.B.03.22
IL-10 and dendritic cells are the main suppression mediators of regulatory T cells in human neurocysticercosis
C. G. Matar, S. H. Speck, T. J. Lamb;
Emory University, Atlanta, GA, United States.
L. J. Ioannidis1,2, A. Ly1,2, C. Q. Nie3, C. Y. Chiu1,2, V. Ryg-Cornejo1,2, D. S. Hansen1,2;
1
The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia, 2Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia, 3Burnet Institute, Melbourne, VIC,
Australia.
P. J. Korir, J. Kuepper, A. Hoerauf, B. Schumak;
Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
A. Zerka1, J. Rydzak1, E. Jaskiewicz1, A. Lass2, B. Szostakowska2, W. Nahorski2, A. Wroczynska2;
1
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences, Wroclaw, Poland, 2Institute of Maritime and Tropical Medicine in Gdynia, Gdynia, Poland.
N. Kalleda1, J. Amich1, B. Arslan1, K. Ottmüller1, K. Muthu Raja1, M. Friedrich2, A. Brandl1, H. Einsele1, M. Brock3, K. Heinze2, A. Beilhack1;
1
IZKF Research Laboratory, Department of Medicine II, University Hospital, Wuerzburg, Wuerzburg, Germany, 2Rudolf-Virchow-Zentrum, University of Wuerzburg, Wuerzburg, Germany, 3Research Group
Microbial Biochemistry and Physiology, Hans Knoell Institute, Jena, Germany.
F. Sparber, S. Leibundgut-Landmann;
Institute of Virology, Zürich, Switzerland.
R. Busch1,2, K. Murti1,2, J. Liu1, A. K. Patra1,2, K. Knobeloch3, M. Lichtinger4, C. Bonifer4, S. Wörtge5, A. Waisman5, K. Reifenberg6, V. Ellenrieder7, E. Serfling1,2, A. Avots1,2;
1
Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany, 2Comprehensive Cancer Center Mainfranken, Wuerzburg, Germany, 3Institute of Neuropathology, University Clinic Freiburg, Freiburg,
Germany, 4Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, 5University Medical Center, Johannes Gutenberg University,
Mainz, Germany, 6German Cancer Research Center, Heidelberg, Germany, 7Department of Gastroenterology II, University of Goettingen, Goettingen, Germany.
A. Arce-Sillas1, D. D. Álvarez-Luquín1, G. Cardenas1, G. Fragoso2, M. Hernández2, A. Fleury1, E. Sciutto2, L. Adalid-Peralta1;
Instituto Nacional de Neurología y Neurocirugía, México city, Mexico, 2Instituto de biomédicas, UNAM, México city, Mexico.
1
P.B.03.23
IL-1 family cytokines in hepatic necrosis and inflammation caused by blood-stage Plasmodium chabaudi malaria
P.B.03.24
Hemozoin is pathogenic in experimental malaria-associated acute respiratory distress syndrome
M. Menezes1, F. Vieira1, É. Salles1, A. Cassado1, K. Bortoluci2, J. Alvarez1, J. Alves-Filho3, M. D’Império-Lima1;
1
University of São Paulo, São Paulo, Brazil, 2Federal University of São Paulo, São Paulo, Brazil, 3University of São Paulo, Ribeirão Preto, Brazil.
K. Deroost1,2, T. Pham1, N. Lays1, J. Deckers3, R. Spaccapelo4, E. Schwarzer5, P. Arese5, M. Komuta6, J. Lin7, C. C. Janse8, G. Opdenakker1, P. E. Van den Steen1;
Rega Institute for Medical Research, KU Leuven - University of Leuven, Leuven, Belgium, 2Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Centro Internacional de Pesquisa Clínica em Malária
(CIPCliM), Manaus, Brazil, 3Cytokine Receptor Laboratory, VIB, University of Ghent, Ghent, Belgium, 4Universita’ degli Studi di Perugia, Perugia, Italy, 5University of Torino, Turin, Italy, 6KU Leuven University of Leuven, Leuven, Belgium, 7MRC National Institute for Medical Research, London, United Kingdom, 8Leiden University Medical Center, Leiden, Netherlands.
1
19
Chairpersons: Geneviève de Saint Basile; Paris, France / Tomas Kalina; Prague, Czech Republic
Monday
P.B.04.01
Detection of rare Mendelian variants involved in basic immunological mechanisms in a cohort of 139 pediatric inflammatory bowel disease patients
P.B.04.02
Hemophagocytic syndrome: the challange of mono-allelic variants
P.B.04.03
Genealogical markers in adults with primary immunodeficiency
N. K. Serwas1, A. Kansu2, E. Santos-Valente1, Z. Kuloğlu2, A. Demir2, A. Yaman2, L. Y. Gamez Diaz3, C. Domínguez Conde1, E. Salzer1, R. Artan4, E. Sayar4, A. Ensari5, B. Grimbacher6, K. Boztug1,7;
1
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, 2Ankara University, Department of Pediatric Gastroenterology, Ankara, Turkey, 3Centre of Chronic
Immunodeficiency,, Freiburg, Germany, 4Akdeniz University, Department of Pediatric Gastroenterology, Antalya, Turkey, 5Ankara University, Department of Pathology, Ankara, Turkey, 6Centre of Chronic
Immunodeficiency, Freiburg, Germany, 7Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
L. Viñas-Giménez1, R. Colobran1, M. Martinez-Gallo1, J. Luis-Dapena1, A. Aguiló1, P. Sole-Palacín1, A. Martín-Nalda1, L. Alsina2;
1
Immunology Division. Vall d’Hebron University Hospital, Barcelona, Spain, 2Allergy and clinical immunology department. Hospital Sant Joan de Déu, Barcelona, Spain.
M. Karakina1, V. Shershnev2, I. Tuzankina1;
1
Ural Federal University named after the first President of Russia B.N. Yeltsin, Ekaterinburg, Russian Federation, 2Institute of of Industrial Ecology, Ekaterinburg, Russian Federation.
P.B.04.04 Subcutaneous panniculitis T-cell lymphoma after total recovery of Hemophagocytic lymphohistiocytosis in a patient with a novel heterozygous mutation in
UNC13D gene
M. Martinez-Gallo1, R. Colobran1, L. Vinas-Gimenez1, L. Alonso-Garcia2, I. Lopez-Lerma3, J. Ferreres3, B. Ferrer3, C. Diaz de Heredia2, R. Pujol Borrell1, J. Dapena2;
1
Hospital U. Vall d’Hebron, Barcelona, Spain, 2Servei d’Oncohematologia pediatrica. Hospital Universitari Vall d’Hebron, Barcelona, Spain, Barcelona, Spain, 3Servei d’Anatomia Patologica Hospital
Universitari Vall d’Hebron, Barcelona, Spain, Barcelona, Spain.
P.B.04.05
Secondary amyloidosis in a patient with HyperIgE syndrom
E. Madany Al-Kheder1, L. Fernández Pereira2, C. Cámara Hijón1, I. Tovar García1, S. Romero Chala1, J. García Trujillo1, I. Mágriz Tascón1;
1
San Pedro de Alcantara Hospital, Caceres, Spain, 2San Pedro de Alcantara Hospital, Cáceres, Spain.
P.B.04.06 Novel homozygous mutations associated with an atypical phenotype of the hyper-IgE syndrome
J. Hartberger1, C. Glocker1, A. Bulashevska1, M. Fliegauf1, N. Frede1, K. Engelhardt1,2,3, A. Schäffer4, A. Etzioni5,6,7, B. Grimbacher1;
Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany, 2Royal Free Hospital and University College London, London, United Kingdom,
3
Institute of Cellular Medicine University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom, 4NCBI, NIH, Department of Health and Human Services, Bethesda, MD, United States, 5Meyer’s
Children Hospital, Haifa, Israel, 6Rambam Health Care Campus and Rappaport Faculty of Medicine, Haifa, Israel, 7Technion-Israel Institute of Technology, Haifa, Israel.
1
P.B.04.07
Senzitisation in atopic dermatitis, STAT3-, and DOCK8-hyper-IgE syndrome
B. Hagl1, A. C. Boos1, B. E. Halm1, A. Schlesinger1, M. Pinarci2, V. Heinz1, D. Kreilinger1, B. D. Spielberger1, J. Sawalle-Belohradsky1, B. H. Belohradsky1, B. Schaub1, B. Przybilla2, A. Wollenberg2, E. D. Renner1;
1
University Children’s Hospital, Ludwig Maximilian University Munich, Munich, Germany, 2Dermatology Hospital, Ludwig Maximilian University Munich, Munich, Germany.
P.B.04.08 Granulocyte activation markers in patients with common variable immunodeficiency (CVID)
J. Litzman1, O. Ticha2, J. Nechvatalova1, M. Vlkova1;
1
Dept. Clin Immunol. Allergol., St Anne´s University Hospital, Brno, Czech Republic, 2Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicine, Langen, Germany.
P.B.04.09 Impaired IgG antibody formation indicates the need for early immunoglobulin replacement in hypogammaglobulinemia
H. M. Wolf1, V. Thon2,3, J. Litzman2,3, M. M. Eibl1;
1
Immunologische Tagesklinik, Vienna, Austria, 2Department of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, 3Department of Clinical Immunology and
Allergology, St. Anne´s University Hospital, Brno, Czech Republic.
P.B.04.10
B cell subpopulation classification: comparison of single & multi-tube preparations
P.B.04.11
A cryptic splice site in GATA2 exon 3 revealed by a novel mutation causing GATA2 haploinsufficiency
P.B.04.12
Thymoma and immunodeficiency - B-cell reconstitution
P.B.04.13
JAK1 deficiency predisposes to mycobacterial infection
H. R. Lock, J. Brooker, S. Grigoriadou, A. Hickey;
Barts Health NHS Trust, London, United Kingdom.
K. Grotius1, C. Wehr1, C. Echternach1, K. Warnatz1, U. Salzer1,2;
1
Centre for Chronic Immunodeficiency, University Hospital of Freiburg, Freiburg, Germany, 2Department of Rheumatology and Clinical Immunology, University Medical Centre Freiburg, Freiburg, Germany.
M. T. Martinez-Saavedra1, T. Molero2, M. A. Cardenes3, J. C. Rivero Vera4, M. Limeres4, A. Prada Iñurrategui5, J. Campoverde6, J. Molero7, N. Matamoros Flori8, M. Martinez-Gallo9, X. de Gracia Roldan10, X.
Solanich11, S. Lopez-Rodriguez10, H. Luzardo2, I. Sologuren1, E. Herrera-Ramos1, M. Lopez-Rodriguez1, Y. Florido1, N. Gonzalez-Quevedo1, C. Rodriguez-Gallego8;
1
Immunology Department, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain, 2Hematology Department, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas
de Gran Canaria, Spain, 3Internal Medicine Department, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain, 4Pathology Department, Hospital Universitario de Gran
Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain, 5Immunology Department, Hospital Universitario Donostia, San Sebastián, San Sebastian, Spain, 6Clinic Immunology Department, Hospital General
Universitario Gregorio Marañon, Madrid, Spain, 7Immunology and Genetics Department, Hospital Infanta Cristina, Badajoz, Spain, 8Immunology Department, Hospital Universitario Son Espases, Palma de
Mallorca, Spain, 9Immunology Department, Hospital Universitario Vall d’Hebron, Barcelona, Spain, 10Pneumology Department, Hospital Universitario Vall d’Hebrón, Barcelona, Spain, 11Internal Medicine
Department, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Spain.
V. Daza Cajigal1, K. Novak2, D. Evangelopoulos3, I. Angulo4, T. D. McHugh3, S. Nejentsev4, A. J. Thrasher2,5, S. O. Burns1;
University College London Institute of Immunity and Transplantation, Department of Immunology, Royal Free London NHS Foundation Trust, London, United Kingdom, 2University College London
Institute of Child Health, Molecular Immunology Unit, London, United Kingdom, 3University College London Centre for Clinical Microbiology, Research Department of Infection, London, United Kingdom,
4
Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 5Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.
1
P.B.04.15
Clinical case of an X-linked Hyper IgM syndrome diagnosed by flow cytometry
M. Rey, P. Echániz, Á. Prada;
Laboratorio Inmunología Hospital Donostia, Donostia-San Sebastian, Spain.
P.B.04.16 Disseminated Mycobacterium fortuitum infection - diagnostic and therapeutic challenges in a child with complete IFNgR1 deficiency
P. Olbrich1,2, M. T. Martinez-Saavedra3, J. Hurtado4, C. Sanchez1,2, B. Sanchez5, C. Deswarte6,7, I. Obando1,2, J. Casanova6,8,9, C. Speckmann10, J. Bustamante6,7,11, C. Rodriguez-Gallego12, O. Neth1,2;
1
Pediatric Infectious Diseases and Immunodeficiency Unit, Hospital Virgen del Rocio, Sevilla, Spain, 2Biomedicine Institute of Sevilla, Sevilla, Spain, 3Immunology Department, Hospital Universitario de
Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain, 4Pediatric Hematology Unit, Hospital Virgen del Rocio, Sevilla, Spain, 5Department of Immunology, Hospital Virgen del Rocio, Sevilla, Spain,
6
Laboratory of Human Genetics of Infectious Diseases, Necker Hospital for Sick Children, Paris, France, 7Paris Descartes University, Imagine Institute, Paris, France, 8Pediatric Hematology-Immunology
Unit, Necker Hospital for Sick Children, Paris, France, 9St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller branch, the Rockefeller University, New York, NY, United States, 10Center for
Chronic Immunodeficiency, University of Freiburg, Freiburg, Germany, 11Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children,, Paris, France, 12Immunolgy Department, Son
Espases University Hospital, Palma de Mallorca, Spain.
P.B.04.17
Late onset and inflammatory bowel disease in a patient with a missense mutation in NEMO (IKBKG)
M. Martinez-Gallo1, O. Segarra2, R. Colobran1, M. Garcia-Prat1, D. Alvarez de la Sierra1, A. Martin-Nalda3, P. Soler-Palacin3;
1
Hospital U. Vall d’Hebron. Servei d’Immunologia, Barcelona, Spain, 2Hospital U. Vall d’Hebron. Unitat de Gastroenterologia Pediàtrica, Barcelona, Spain, 3Hospital U. Vall d’Hebron. Unitat de Malalties
infeccioses i immunodeficiències pediàtriques, Barcelona, Spain.
P.B.04.18 Severe congenital neutropenia in Turkish patient living in the South Marmara region
S. Kilic1, O. Gorukmez2, T. Yakut2, D. Hafizoglu1, E. Asut1, S. Cekic1;
1
Uludag University Medical Faculty, Department of Pediatrics, Bursa, Turkey, 2Uludag University Medical Faculty, Department of Genetics, Bursa, Turkey.
P.B.04.19 New diagnostic aplication for X-linked Chronic Granulomatous Disease
M. Y. Koker1,2, B. Saraymen1, E. Bentli1, H. Çelikzencir1, H. Avcılar1;
1
University of Erciyes, Department of Immunology, Kayseri, Turkey, 2Kök Biotek Ar-Ge, Technocity of University of Erciyes, Kayseri, Turkey.
20
P.B.04.20
Diagnostic conflic in MPO deficiency and AR-CGD with DHR assay
P.B.04.21
Detecion of CD19, ICOS, TACI gene mutations in Turkish CVID patients
P.B.04.22
Analysis of inhibitory 2B4 receptor in NK cells from XLP1 patients: diagnostic tool and differential capability to inhibit various activating pathways
M. Y. Koker1, G. Akyol2, L. Kaynar2, S. Akpınar1, H. Avcılar1, B. Eser2, M. Çetin2, A. Ünal2;
1
Department of Immunology, University of Erciyes, Kayseri, Turkey, 2Division of Hematology, University of Erciyes, Kayseri, Turkey.
S. Şişko1, A. A. Kıykım2, S. Barış2, E. Aydıner2, S. Nepesov3, Ö. Hatırnaz Ng1, S. Çınar4, M. Sayitoğlu1, I. B. Barlan2, Y. Camcıoğlu3, G. Deniz4, U. Özbek1, Y. Y. Ng5;
1
Istanbul University,Istanbul University Institute for Experimental Medicine Research,Department of Genetics, Istanbul, Turkey, 2Marmara University Faculty of Medicine Department of Allergy-Immunology,
Istanbul, Turkey, 3Istanbul University,Cerahpaşa Medical Faculty,Department of Child Health and Diseases, Istanbul, Turkey, 4Istanbul University,Istanbul University Institute for Experimental Medicine
Research,Department of Immunology, Istanbul, Turkey, 5Istanbul Bilgi University, Department of Genetics and Bioengineering, Istanbul, Turkey.
R. Meazza1, C. Tuberosa2, V. Cetica3, M. Falco4, F. Loiacono4, M. C. Mingari1,2, L. Moretta4, C. Bottino2,4, M. Aricò3,5, D. Pende1;
1
IRCCS AOU San Martino-IST, Genova, Italy, 2Department of Experimental Medicine, University of Genova, Genova, Italy, 3Department of Pediatric Onco-Hematology, AOU Meyer, Florence, Italy, 4IRCCS
Istituto Giannina Gaslini, Genova, Italy, 5Istituto Toscano Tumori, Florence, Italy.
P.B.04.23
A new IL-2RG gene mutation in an x-linked SCID identified through TREC/KREC screening: a case report
P.B.04.24
Neonatal mortality in children with lymphopenia
M. A. Bolkov1,2, I. A. Tuzankina1,2, S. S. Deryabina2,1, A. A. Konoplev2, E. V. Vlasova1, E. L. Istomina1;
1
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russian Federation, 2Federal State Autonomous Educational Institution of Higher
Professional Education «Ural Federal University named after the first President of Russia B.N.Yeltsin», Yekaterinburg, Russian Federation.
P.B.05 Autoinflammatory Diseases
Chairpersons: Haluk Barbaros B. Oral; Bursa, Turkey / Clemens Scheinecker; Vienna, Austria
P.B.05.01
ANCA antibodies: A 3-year study at a tertiary hospital of Western Greece
P.B.05.02
Deciphering the transcriptomic signatures linked with atopic dermatitis in humans: A systems immunological approach
P.B.05.03
An autoimmune polyglandular syndrome type 3 complicated with celiac disease and autoimmune hepatitis: case report and literature review
P.B.05.04
Lower proportions of CD19+CD24hiCD27+IL-10+ and CD19+IL-10+ , but not CD1d+CD5+CD19+CD24+CD27+IL-10+ B cell levels in children with autoimmune
thyroid diseases
1
Monday
M. Nourizadeh1, S. Borte2,3, M. Fazlollahi1, L. Hammarström2, Z. Pourpak1;
1
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 2Division of Clinical Immunology, Department of Laboratory Medicine,
Karolinska University Hospital Huddinge, Stockholm, Sweden, 3Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Municipal Hospital St. Georg,, Leipzig, Germany.
P. Pushparaj1, L. A. Damiati2, S. Bahlas3, K. Gauthaman1;
1
Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia, 2King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia, 3Department of
Internal Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
R. Dieli-Crimi1, C. Núñez1, L. Estrada2, L. Fernández-Paredes1, N. López-Palacios3;
1
UGC de Inmunología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain, 2Servicio de Anatomía Patológica, Hospital Clínico San Carlos,
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain, 3Servicio de Digestivo, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San
Carlos (IdISSC), Madrid, Spain.
A. Bossowski1, K. Grubczak2, P. Singh2, U. Radzikowska2, P. Mikłasz2, M. Dabrowska3, A. Bossowska4, M. Moniuszko5;
1
Dep. of Pediatric Endocrinology and Diabetes with a Cardiology Unit. Medical University in Bialystok., Bialystok, Poland, 2Department of Regenerative Medicine and Immune Regulation, Bialystok, Poland,
3
Department of Hematology Diagnostic. Medical University in Bialystok., Bialystok, Poland, 4Division of Cardiology, Internal Affairs Ministry Hospital in Białystok,, Bialystok, Poland, 5Department of
Regenerative Medicine and Immune Regulation. Medical University in Bialystok, Bialystok, Poland.
P.B.05.05
S100A8/A9 as reliable inflammation marker in experimental autoimmune uveoretinitis (EAU) in mice
P.B.05.06
Interleukin 1 blockade with canakinumab for Hyper IGD syndrome (HIDS)
P.B.05.07
IL-17 expression by lymphocytes is higher in Behcet’s disease compared to Takayasu’s arteritis
P.B.05.08
Anti-Bacterial Permeability Increasing antibody: Other antigenic target of the ANCA
P.B.05.09
Positive ANCA Vasculitis: about 18 cases
P.B.05.10
Cryopyrin associated periodic syndromes (CAPS): immunological characterization of knock-in mouse model to exploit novel approaches for the modulation of the
NLRP3 inflammasome
M. Kasper1, T. Vogl2, L. Wildschuetz1,3, S. Zenker1, D. Bauer1, S. Thanos4, M. Karlstetter5, T. Langmann5, J. Roth2, A. Heiligenhaus1,3;
1
Department of Ophthalmology at St. Franziskus Hospital, Ophtha-Lab, Muenster, Germany, 2Institute of Immunology, Westfalian Wilhelms-University of Muenster, Muenster, Germany, 3University of
Duisburg-Essen, Essen, Germany, 4Institute for Experimental Ophthalmology, Westfalian Wilhelms-University of Muenster, Muenster, Germany, 5Laboratory for Experimental Immunology of the Eye,
Department of Ophthalmology University of Cologne, Cologne, Germany.
J. Brunner, E. Binder, D. Karall, J. Zschocke, C. Fauth;
Medical University Innsbruck, Innsbruck, Austria.
F. T. Özdemir1, R. Deniz2, A. T. Virlan1, I. A. Tatlı1, G. Ozen3, F. A. Oner3, A. U. Unal3, G. Mumcu4, T. Ergun5, H. Direskeneli3;
1
Marmara University, School of Medicine, Department of Immunology, Istanbul, Turkey, 2Marmara University, School of Medicine, Istanbul, Turkey, 3Marmara University, School of Medicine, Department
of Rheumatology, Istanbul, Turkey, 4Marmara University, Faculty of Health Sciences, Department of Health Management, Istanbul, Turkey, 5Marmara University, School of Medicine, Department of
Dermatology, Istanbul, Turkey.
S. Gadiri1, H. Meriche1, L. Benmeiza2;
1
Department of Immunology, Pediatric Clinic of St Therese, Annaba, Algeria, 2Department of Internal Medicine, Ibn Sina Hospital, Annaba, Algeria.
S. Gadiri Meriche1, H. Meriche1, A. Alliouche Kerboua1, A. Atik2;
1
Department of Immunology, St Thérèse Pediatric Clinic, Annaba, Algeria, 2Department of Nephrology, Ibn Sina Hospital, Annaba CHU, Annaba, Algeria.
A. Bertoni1,2, S. Carta3, E. Balza3, S. Borghini4, P. Castellani3, C. Pellecchia3, F. Penco1, F. Schena1, M. Trotta1,2, C. Pastorino1, I. Ceccherini4, A. Martini1, M. Gattorno1, A. Rubartelli3, S. Chiesa1;
1
Laboratorio di Immunologia delle Malattie Reumatiche, G.Gaslini Institute, Genova, Italy, 2Università degli studi di Genova, Genova, Italy, 3Unità di biologia cellulare, IRCCS San Martino-IST, Genova, Italy,
4
Genetica medica, G.Gaslini Institute, Genova, Italy.
P.B.05.11
The killed Dietzia maris inhibits IL-6 production from LPS-induced murine activated macrophages
P.B.05.12
Oral suspension of heat-killed Dietzia maris suppresses nitric oxide production in murine LPS-stimulated peritoneal macrophages
B. Ghahvechi1, K. Nofouzi2, M. Aghapour2, B. Baradaran3, F. Mahmoodi3, F. Yahyavi4;
1
Department of Microbiology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran, Islamic Republic of, 2Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran,
Islamic Republic of, 3Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of, 4Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz,
Tabriz, Iran, Islamic Republic of.
B. Ghahvechi1, K. Nofouzi2, M. Aghapour2, K. Tahapour2, B. Baradaran3, F. Mahmoodi3;
Department of Microbiology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran, Islamic Republic of, 2Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran,
Islamic Republic of, 3Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of.
1
P.B.05.13
Gene mosaicism in autoinflammatory diseases: Insights from a Spanish centre
P.B.05.14
tertiary lymphoid organs form during the long term course of murine glomerulonephritis
P.B.05.15
Monosodium glutamate has very low potential for provoking inflammation-based clinical symptoms
P.B.05.16
HSP60 as an autoantigen in obesity
P.B.05.17
Myositis autoantibodies in Tunisian patients with idiopathic inflammatory myopathies
P.B.05.18
The immune-suppressive effects of heat-inactivated Tsukamurella inchonensis on the release of Interleukin-6 (IL-6) by activated peritoneal macrophages
A. Mensa-Vilaro1, E. Gonzalez-Roca1, D. Clemente2, S. Murias3, J. Callejas4, J. Cañellas5, A. Souto6, J. Campistol7, S. Jimenez-Treviño8, C. Delgado9, E. Enriquez-Merayo10, P. Tejada-Palacios11, S. Ping Tang12,
E. Ruiz-Ortiz1, F. Rius1, S. Plaza1, M. Anton1, J. Lopez-Robledillo2, R. Merino3, N. Ortego4, M. Bosque9, J. de Inocencio10, W. Tarng Cham12, J. Yagüe1, J. Arostegui1;
1
Immunology Department, Hospital Clinic-IDIBAPS, Barcelona, Spain, 2Pediatric Rheumatology Department, Hospital del Niño Jesus, Madrid, Spain, 3Pediatric Rheumatology Department, Hospital de La
Paz, Madrid, Spain, 4Autoimmune Diseases Department, Hospital San Cecilio, Granada, Spain, 5Rheumatology Department, Hospital Germans Trias i Pujol, Badalona, Spain, 6Rheumatology Department,
Hospital Universitario de Santiago de Compostela, Santiago de Compostela, Spain, 7Nephrology Department, Hospital Clinic-IDIBAPS, Barcelona, Spain, 8Pediatrics Department, Hospital Central de
Asturias, Oviedo, Spain, 9Rheumatology Department, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain, 10Pediatric Rheumatology Department, Hospital Universitario 12 de Octubre, Madrid,
Spain, 11Ophthalmology Department, Hospital Universitario 12 de Octubre, Madrid, Spain, 12Selayang Hospital, Kuala Lumpur, Malaysia.
C. Schabhuettl1, A. H. Kirsch1, K. Artinger1, I. Aringer1, A. R. Rosenkranz1, P. Eller2, K. Eller1;
1
Division of Nephrology, Graz, Austria, 2Division of Angiology, Graz, Austria.
D. E. Maddox;
Mayo Clinic, Rochester, MN, United States.
M. Selli, D. C. Wraith, A. C. Newby;
University of Bristol, Bristol, United Kingdom.
L. Laadhar1, F. Azaiez1, I. Ben Ghorbel2, M. Kallel-Sellami1, H. Houman2;
1
Immunology Department, la Rabta hospital, Tunis, Tunisia, 2Internal Medicine Department, La Rabta Hospital, Tunis, Tunisia.
M. Aghapour1, K. Nofouzi1, B. Ghahvechi2, B. Baradaran3, F. Mahmoodi3;
1
Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran, Islamic Republic of, 2Department of Microbiology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran,
21
Monday
P.B.05.19
TRP channels overexpression contributes to inflammasome activation in clavicular cortical hyperostosis?
P.B.05.20
Interleukin-1 receptor antagonist deficiency with a novel mutation; late onset and a successful treatment with canakinumab: a case report
P.B.05.21
Cytotoxic profile of CD4+ T encephalitogenic cells during the evolution of the experimental autoimmune encephalomyelitis
L. Lamot1, M. Vidovic2, M. Perica2, L. Tambic Bukovac2, K. Gotovac1, F. Borovecki1, M. Harjacek2;
1
University of Zagreb School of Medicine, Zagreb, Croatia, 2Children’s Hospital Srebrnjak, Zagreb, Croatia.
N. E. Karaca1, E. Ulusoy1, E. Azarsiz1, H. El-Shanti2, G. Aksu1, N. Kutukculer1;
1
Ege University Medical School, Izmir, Turkey, 2Qatar Biomedical Research Institute, Medical Genetics Center, Doha, Qatar.
F. Pradella, G. A. Morais, C. Francelin, E. S. Fonseca, A. F. Longhini, M. Rocha-Parise, G. A. Silva, L. M. Santos, A. S. Farias;
UNICAMP, Campinas - SP, Brazil.
Chairpersons: Annemiek van Spriel; Nijmegen, Netherlands / Manfred B. Lutz; Würzburg, Germany
P.B.06.01
Activation of Annexin A1-FPR2 axis promotes resolution of house dust mite induced airway hyper-reactivity
P.B.06.02
The effect of folate status on pro-inflammatory cytokines expression of mesangial cells
P.B.06.03
S100A4 promotes liver fibrosis via activation of hepatic stellate cells
S. A. Mathie1, S. Bena2, V. Hammond3, M. Mondae3, G. Scadding1, M. H. Shamji1, D. Davda1, S. Durham1, M. Perretti2, V. O’Donnell3, C. M. Lloyd1;
1
Imperial College London, London, United Kingdom, 2William Harvey Research Institute, Barts School of Medicine, United Kingdom, 3Cardiff Institute of Infection & Immunity, University of Cardiff, United
Kingdom.
X. L. Koh, B. F. Lin;
National Taiwan University, Taipei, Taiwan.
Z. Qin1,2, L. Chen1,2,3, J. Li1,2,3;
1
Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2Chinese Academy of Sciences-University of Tokyo Joint Laboratory of Structural Virology and Immunology, Institute of Biophysics,
Chinese Academy of Sciences, Beijing, China, 3University of Chinese Academy of Sciences, Beijing, China.
P.B.06.04 In vitro functional study of the effect of polymorphism ANXA11 rs1049550 on the formation of granulomas
R. Fillerova1, P. Gregorova1, M. Zurkova2, T. Tichy3, V. Lostakova2, V. Kolek2, E. Kriegova1;
1
Dept. of Immunology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic, 2Dept. of Respiratory Diseases, Faculty of Medicine and Dentistry, Palacky University, Olomouc,
Czech Republic, 3Dept. of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
P.B.06.05
Elastin peptides modulate T helper response during murine emphysema
A. Meghraoui-Kheddar1, M. Sellami1, S. Audonnet2, M. Guenounou1, R. Le Naour1;
1
EA4683, SFR CAP-Santé, Université de Reims Champagne-Ardenne (URCA), REIMS, France, 2Plateau technique de Cytométrie en flux, Plateforme Santé, URCA, REIMS, France.
P.B.06.06 Platelets induce Thymic Stromal Lymphopoietin production by Endothelial Cells: contribution to human systemic sclerosis fibrosis
M. Truchetet1,2, B. Demoures2, J. Guimaraes2, P. Laurent2, I. Douchet2, C. Jacquemin2, P. Duffau3,2, E. Lazaro4,2, C. Richez1,2, J. Seneschal5, J. Constans6, J. Pellegrin4, T. Schaeverbeke1, P. Blanco2,7, C. ContinBordes2,8;
1
Rheumatology Department Bordeaux Hospital, Bordeaux, France, 2UMR CNRS 5164 CIRID Bordeaux University, Bordeaux, France, 3Internal Medecine Department Bordeaux Hospital, Bordeaux, France,
4
Internal Medicine Department Bordeaux Hospital, Bordeaux, France, 5Dermatology Department Bordeaux Hospital, Bordeaux, France, 6Vascular Medicine Department Bordeaux Hospita, Bordeaux,
France, 7Immunology and Immunogenetic Department Bordeaux Hospital, Bordeaux, France, Bordeaux, France, 8Immunology and Immunogenetic Department Bordeaux Hospital, Bordeaux, France.
P.B.06.07
Tumour necrosis factor-related apoptosis inducing ligand promotes the development of experimental chronic obstructive pulmonary disease
T. J. Haw1, M. R. Starkey1, P. M. Nair1, I. Hanish1,2, D. H. Nguyen1, G. Liu1, M. D. Inman3, R. Y. Kim1, A. M. Collison1, D. A. Knight1, H. Yagita4, J. Mattes1, J. C. Horvat1, P. M. Hansbro1;
1
Hunter Medical Research Institute and University of Newcastle, New Lambton Heights, Australia, 2Department of Microbiology and Universiti Putra Malaysia, Serdang, Malaysia, 3Firestone Institute for
Respiratory Health and McMaster University, Hamilton, ON, Canada, 4Department of Immunology and Juntendo University School of Medicine, Tokyo, Japan.
P.B.06.08 Genetic polymorphism and expression of TNFα And TGFβ genes in patients with chronic lower limbs infections connected with wound healing problem.
M. Zagozda1,2, A. Sarnecka1,2, Z. Staszczak1,3, H. Galkowska1, W. L. Olszewski1,2, M. Durlik1,2;
1
Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland, 2Central Clinical Hospital, Ministry of Internal Affairs, Warsaw, Poland, 3College of Inter-Faculty Individual Studies in
Mathematics and Natural Sciences, Warsaw, Poland.
P.B.06.10
Effects of alcohol extracts from Huiyang Shengji Gao on macrophage efferocytosis and phenotype transition
P.B.06.11
Antibodies of intestinal profile in patients with Crohn’s disease
P.B.06.12
Anti-tumor necrosis factor therapy restores of Foxp3(+) regulatory T cell subsets and Foxp3(-) type 1 regulatory-like T cells in inflammatory bowel diseases
P.B.06.13
Wild bitter gourd prevents dextran sulfate sodium-induced colitis by enhancing intestinal regulatory T cells
Y. Lin;
Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing, China.
M. Karakina1, A. Оshepkov2, G. Tsaur1, I. Pashnina1;
1
Institute Immunology and Phisiology, Ekaterinburg, Russian Federation, 2Region Clinical Hospital, Ekaterinburg, Russian Federation.
Z. Li1, S. Vermeire1, D. Bullens1, M. Ferrante1, K. Van Steen1,2, M. Noman1, P. Rutgeerts1, J. L. Ceuppens1, G. Van Assche1;
1
Catholic University of Leuven, Leuven, Belgium, 2Université de Liège, Université de Liège, Belgium.
H. Lu, B. Lin;
P.B.06.14 A critical role for CD101 in the maintenance of intestinal homeostasis
J. Mattner;
FAU Erlangen, Erlangen, Germany.
P.B.06.15
Intestinal epithelial cell tyrosine kinase 2 transduces interleukin-22 signals to protect from acute colitis
E. Hainzl1, I. Rauch2,3, S. Heider4, C. Lassnig1, S. Stockinger1, L. Kenner1,4,5, T. Decker2, B. Strobl1, M. Müller1;
1
University of Veterinary Medicine, Vienna, Vienna, Austria, 2University of Vienna, Vienna, Austria, 3University of California, Berkeley, CA, United States, 4Ludwig Boltzmann Institute for Cancer Research,
Vienna, Austria, 5Medical University Vienna, Vienna, Austria.
P.B.06.16 Immunoproteasome is a promising target molecule for the treatment of colitis-associated carcinogenesis
N. Vachharajani1, M. Hofer2,3, G. Pantazis2, A. Hellhund1, A. Pagenstecher2, U. Steinhoff1, A. Višekruna1;
1
Institut für medizinische Mikrobiologie,Philipps-Universität, Marburg, Germany, 2Neuropathologie, Philipps-Universität, Marburg, Germany, 3School of Molecular Bioscience, The University of Sydney,
Sydney, Australia.
P.B.06.18 No evidence for a role of the histamine H4-receptor in chronic DSS-induced colitis
B. Schirmer, T. Rezniczek, R. Isaev, R. Seifert, D. Neumann;
P.B.06.19 Hyperbaric oxygenation modulates homing properties of GALT in BALB/c mice with DSS induced colitis
M. Mihalj, S. Novak, A. Cosic, I. Drenjancevic;
Faculty of Medicine University of Osijek, Osijek, Croatia.
P.B.06.20
HIF-1α gene expression correlates to SOD1 and GPx1 gene expression during gut inflammation and hyperbaric oxygenation in BALB/c mice
S. Novak, A. Cosic, I. Drenjancevic, M. Mihalj;
Faculty of Medicine University of Osijek, Osijek, Croatia.
P.B.07 Neuroimmunology
Chairpersons: Yvonne Dombrowski; Belfast, United Kingdom / Alexander Scheffold; Bergisch Gladbach, Germany
P.B.07.01
22
Autoantibodies towards the angiotensin 2 type 1 receptor. A novel autoantibody in Alzheimer’s disease
L. M. Giil1, E. K. Kristoffersen2,3, C. A. Vedeler4, D. Aarsland5,6, J. Nordrehaug2,7, B. Winblad5, A. Cedazo-Minguez5, A. Lund2, T. R. Reksten3,6;
1
Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway, 2Institute of Clinical Science, University of Bergen, Bergen, Norway, 3Department of Immunology and Transfusion
Medicine, Haukeland University Hospital, Bergen, Norway, 4Institute of Clinical Medicine, University of Bergen, Bergen, Norway, 5Department of Neurobiology, Care Sciences and Society, Center for
Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden, 6Centre for Age-Related Diseases (SESAM), Stavanger University Hospital, Stavanger, Norway, 7Department of
Cardiology, Stavanger University Hospital, Stavanger, Norway.
P.B.07.02
Higher chemokine production by peripheral monocytes after alpha-synuclein stimulation
P.B.07.04
MCMV infection in neonatal and adult mice induces susceptibility to EAE in resistant BALB/c mice
P.B.07.05
GPCR expression during neuroinflammation: A comparative multiplexed-analysis on the single cell level
P.B.07.06
Extended B cell phenotype in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: a cross-sectional study
P.B.07.07
expression of CD56 positive fenotype on monocytes in patients with high grade astrocytoma
P.B.07.08
Epstein-Barr virus selectively affects Th1-type cytokine response in patients with myalgic encephalomyelitis
P.B.07.09
Implication of CD8+ T cells in the pathophysiology of amyotrophic lateral sclerosis
P.B.07.10
Inflammasomes are expressed in demyelinated CNS lesions
P.B.07.12
Apigenin, a natural flavonoid, attenuates EAE severity through modulation of dendritic and other immune cell functions.
P.B.07.14
Brain inflammation-related genes during canine visceral leishmaniasis
P.B.07.15
Model for interaction of immune and neuronal systems in neurodegeneration
P.B.07.16
Neuronal surface antibodies in patients with psychosis
P.B.07.17
NMDA-receptor antibody positivity in patients with Herpes virus type 7 encephalitis
P.B.07.18
HLA-G, HLA-E and HLA-F polymorphisms and soluble HLA-G protein levels in Tunisian autistic families
P.B.07.19
Disturbances in the immune system of mice with high and low sensitivity to stress
P.B.07.20
Identification of molecular chaperones as modulators of the alpha-synuclein-elicited immune response
P.B.07.21
CD4+ T cell reactivity to orexin/hypocretin in patients with narcolepsy with cataplexy
P.B.07.22
Peripheral blood cytokines as biomarkers in amyotrophic lateral sclerosis
P.B.07.23
Potential mechanisms in MuSK myasthenia gravis
J. Milovanovic1, M. Milovanovic2, A. Arsenijevic2, B. Stojanovic1, B. Popovic3, N. Arsenijevic2, S. Jonjic3, M. L. Lukic2;
1
Faculty of Medical Sciences University of Kragujevac, Kragujevac, Serbia, 2Center for Molecular Medicine Faculty of Medical Sciences University of Kragujevac, Kragujevac, Serbia, 3Center for Proteomics,
Department for Histology and Embryology, School of Medicine, University of Rijeka, Rijeka, Croatia.
D. Tischner1, M. Grimm1, H. Kaur1, F. Wanke2, F. Kurschus2, N. Wettschureck1;
1
Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany, 2Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg
University Mainz, Mainz, Germany.
F. Mensah1, A. Bansal2, S. Berkovitz3, M. Leandro1, C. Ciurtin1, G. Cambridge1;
1
University College London, London, United Kingdom, 2St Helier University Hospitals NHS Trust, London, United Kingdom, 3Royal London Hospital for Integrated Medicine, London, United Kingdom.
Monday
D. Goldeck1, L. Oettinger1, W. Maetzler2,3, D. Berg2,3, G. Pawelec1;
1
Second Department of Internal Medicine, University of Tübingen, Tübingen, Germany, 2Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Tübingen, Germany, 3German Center
of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.
E. Slavov1, I. Koev2, D. Staykov2, K. Halacheva1, V. Sarafian2;
1
Trakia University, Stara Zagora, Bulgaria, 2Medical University, Plovdiv, Bulgaria.
I. K. Malashenkova1, S. A. Krynskiy1,2, N. A. Hailov1, G. V. Kazanova1, E. I. Dobrovolskaia1, N. A. Didkovsky2, D. P. Ogurtsov2, O. G. Gurskaia2, M. A. Dzarova2, O. Y. Shipulina3, E. A. Domonova3, O. Y.
Silveistrova3;
1
NRC “Kurchatov Instutute”, Moscow, Russian Federation, 2Science Research Institute of Physical-Chemical Medicine, Moscow, Russian Federation, 3Central Research Institute for Epidemiology of
Rospotrebnadzor, Moscow, Russian Federation.
E. Coque1, G. Carrasco2, C. Salsac1, M. Libralato1, E. Torres1, F. Scamps1, T. Vincent3, J. Hernandez2, C. Raoul1;
1
INSERM U1051, Institute for Neuroscience of Montpellier, Montpellier, France, 2INSERM U844, Montpellier, France, 3Hopital Saint Eloi, Immunology department, Montpellier, France.
S. Fleville, M. Dittmer, D. C. Fitzgerald, Y. Dombrowski;
Queen’s University Belfast, Belfast, United Kingdom.
R. A. Ginwala1, E. McTish1, N. Singh2, C. Raman3, M. Nagarkatti2, P. Jain1, Z. K. Khan1;
1
Drexel University College of Medicine, Philadelphia, PA, United States, 2University of South Carolina, Columbia, SC, United States, 3University of Alabama School of Medicine, Birmingham, AL, United
States.
F. G. Grano, J. E. Silva, G. D. Melo, G. F. Machado;
College of Veterinary Medicine, Univ Estadual Paulista, Araçatuba, Brazil.
M. Zilkova1,2, P. Majerova2, Z. Kazmerova1,2, B. Kovacech1,2, M. Novak1,2, E. Kontsekova1,2;
1
Institute of Neuroimmunology, Slovak Academy of Sciences, AD Centre, Bratislava, Slovakia, 2AXON Neuroscience SE, Bratislava, Slovakia.
V. Cunill1,2, S. Arboleya3, A. Clemente1,2, M. R. Jiménez1,2, M. leyes4, S. Deng3, M. Bedmar5, I. Salvador5, P. Herbera3, C. Vives6,2, F. Canellas3, M. R. Julià1,2;
1
Department of Immunology, Hospital Universitari Son Espases, Palma de Mallorca, Spain, 2Institut d’Investigació Sanitària de Palma (IdISPa), Palma de Mallorca, Spain, 3Department of Psychiatry,
Hospital Universitari Son Espases, Palma de Mallorca, Spain, 4Department of Intenal Medicine, Hospital Universitari Son Espases, Palma de Mallorca, Spain, 5Institut Balear de Salut Mental de la infancia i
l’adolescencia, Palma de Mallorca, Spain, 6Research Unit, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
I. Gañán1, M. J. Rodríguez2, A. Tejeda1, A. Jiménez-Escrig3, Á. Carrasco1;
1
Servicio Inmunología, Hospital Ramón y Cajal, Madrid, Spain, 2Servicio de Microbiología, Hospital Ramón y Cajal, Madrid, Spain, 3Servicio de Neurología, Hospital Ramón y Cajal, Madrid, Spain.
N. Kharrat1, I. Ayadi2, R. Rizzo3, D. Bortolotti3, I. Gtif1, H. Kamdougha1, N. Bouayed Abdelmoula4, F. Ghribi5, A. Rebai1, I. Zidi6;
1
Centre de Biotechnologie de Sfax, laboratory of microorganismes and biomolecules route Sidi Mansour, Sfax, Tunisia, 2Faculté des Sciences de Sfax, Route de la Soukra km 4, Sfax, Tunisia, 3Department of
Experimental and Diagnostic Medicine, Section Microbiology, University of Ferrara, Ferrara, Italy, 4Faculté de Médecine de Sfax, Laboratory of Histology, Avenue Majida Bou Leila, Sfax, Tunisia, 5Hospital of
Hedi chaker (CHU), Service de psychiatrie, Route el Ain Km0.5, Sfax, Tunisia, 6Laboratory Microorganismes et Biomolécules Actives, Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia.
K. Bien1, M. Krzyzowska1, P. Orlowski1, J. Fichna2, M. Sacharczuk3;
1
Military Institute of Hygiene and Epidemiology, Warsaw, Poland, 2Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland, 3Institute of Genetics and Animal Breeding,
Polish Academy of Sciences, Jastrzebiec, Poland.
A. Labrador-Garrido1,2, M. Cejudo-Guillén1,2, M. M. Leal1, S. Daturpalli3, R. Klippstein1,2, E. J. De Genst3, C. M. Dobson3, S. E. Jackson3, D. Pozo1, C. Roodveldt1;
1
CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, Spain, 2Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of
Seville, Seville, Spain, 3Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
M. Ramberger, B. Högl, A. Stefani, T. Mitterling, B. Frauscher, A. Lutterotti, M. Reindl;
Medical University of Innsbruck, Innsbruck, Austria.
A. I. Rodriguez-Mahillo1, Y. Moran2, P. Carbajo2, N. Carballeda-Sangiao1, J. Mascias2, M. Hernandez2, D. Chaverri2, J. S. Mora2, M. González-Muñoz3;
1
FIB-Hospital Universitario La Paz, Madrid, Spain, 2ALS Unit, Neurology Department, HCIII-Hospital Universitario La Paz, Madrid, Spain, 3Immunology Department, HCIII-Hospital Universitario La Paz,
Madrid, Spain.
I. Koneczny1,2, J. A. Cossins2, M. I. Leite2, B. Lang2, D. Beeson2, A. Vincent2;
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, 2Nuffield Department of Clinical Neurosciences and
Weatherall Institute of Molecular Medicine, Oxford University, Oxford, United Kingdom.
1
P.B.07.24
Exaggerated inflammatory response of microglia in two distinct mouse models of brain aging
P.B.07.25
Molecular characterisation of cortactin autoantigen in miastenia gravis and autoimmune myositis patients
J. Laman, B. Eggen, I. Holtman, D. Raj, E. Boddeke;
UMC Groningen, Groningen, Netherlands.
M. Benito-León1, I. Monge-Lobo1, A. Selva-O’Callaghan2, I. Illa3, M. A. Martínez4, C. Juárez4, J. M. Martin-Villa1, N. Martínez-Quiles1;
1
Division of Immunology, School of Medicine, Complutense University, Madrid, Spain, 2Internal Medicine Department, Vall d’Hebron General Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain,
3
Neuromuscular Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain, 4Immunology Department, Hospital de la Santa Creu i Sant Pau, Universitat
Autónoma de Barcelona, Barcelona, Spain.
P.B.08 Diabetes and (Chronic) Inflammatory Joint Diseases
Chairpersons: Lucienne Chatenoud; Paris, France / Matthias Lochner; Hannover, Germany
P.B.08.01 level of angiopoietins and vascular endothelial growth factor in diabetic patient with renal complication
L. H. Damanhouri;
King Abdulaziz university, Jeddah, Saudi Arabia.
P.B.08.02
A link between plasma levels of Fetuin-A and CRP in diabetic obese individuals
A. Wilson, S. Sindhu, R. Ahmad;
Dasman Diabetes Institute, Kuwait, Kuwait.
23
P.B.08.03
HLA-E and HLA-F polymorphisms associated with Type 1 diabetes
w. Babay1, N. Nefzi1, E. Zeddini1, A. Laaribi1, H. Ben Yahia1, A. Bouaziz2, H. Tlili3, I. Zidi1;
1
Laboratory Microorganismes et Biomolécules Actives, Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia, 2Ecole supérieure des Sciences et Techniques de la Santé de Sousse, Sousse,
Tunisia, 3Groupement de sante de base, Sousse, Tunisia.
P.B.08.04 A study of high sensitive C-reactive protein levels between diabetic and non-diabetic patients with coronary artery disease
S. Das, S. Gupta;
Maulana azad medical college, New Delhi, India.
Monday
P.B.08.05
Cytomegalovirus infection enhances development of diabetes mellitus type 2 in obesity
M. Šestan, S. Valentić, F. M. Wensveen, B. Polić;
University of Rijeka; School of Medicine, Rijeka, Croatia.
P.B.08.06 IVS1 -397T>C estrogen receptor α gene polymorphism affects the course of type 1 diabetes mellitus
B. Słomiński1, M. Ryba-Stanisławowska1, M. Skrzypkowska1, A. Brandt2, U. Juhas1, J. Myśliwska1;
1
Medical University of Gdańsk, Department of Immunology, Gdańsk, Poland, 2Medical University of Gdańsk, Chairpersons: and Clinics of Paediatrics, Diabetology and Endocrinology, Gdańsk, Poland.
P.B.08.07
DHA abrogates the inflammatory state of macrophages from type I diabetic mice
M. R. Davanso, A. Crisma, N. Camara, R. Curi;
University of Sao Paulo, Sao Paulo, Brazil.
P.B.08.08 Low-grade inflammation associated with high risky individual for type 2 diabetes mellitus
Y. Tutuncu, M. Kanitez, N. Dinccag, K. Karsidag, I. Satman;
Istanbul University,Istanbul Medical Faculty, Dept. Internal Medicine, Div.Endocrinology& Metabolism, Istanbul, Turkey.
P.B.08.09 NK cells link obesity-induced adipose stress to inflammation and insulin resistance
F. M. Wensveen1, V. Jelenčić1, M. Šestan1, S. Valentić1, T. Turk Wensveen2, S. Theurich3, A. Glasner4, D. Mendrila5, D. Štimac5, T. F. Wunderlich3, J. Brüning3, O. Mandelboim4, B. Polić1;
Univ. of Rijeka, School of Medicine, Rijeka, Croatia, 2Rijeka Clinical Hospital center, Rijeka, Croatia, 3Max Planck institute Cologne, Cologne, Germany, 4The Lautenberg Center for General and Tumor
Immunology, Jerusalem, Israel, 5Rijeka Clinical Hospital Center, Rijeka, Croatia.
1
P.B.08.10 Modulation of Sphingosin-1-Phosphate receptor 1 in Non-Obese Diabetic mouse T-cell migration disorders
J. P. Lemos1, S. Smaniotto2, C. V. Messias1, V. Cotta-de-Almeida1, M. Dardenne3, W. Savino1, D. Mendes-da-Cruz1;
Oswaldo Cruz Foundation/ Fiocruz, Rio de Janeiro, Brazil, 2Federal University of Alagoas, Maceió, Brazil, 3Paris Descartes University, Paris, France.
1
P.B.08.11
Elevated frequencies of CD14brightCD16+ and CD14dimCD16+monocytes in patients with type 1 diabetes may predispose to the development of diabetic
retinopathy
M. Ryba-Stanisławowska1, U. Juhas1, B. Słomiński1, M. Myśliwiec2, J. Myśliwska1;
1
Medical University of Gdańsk, Department of Immunology, Gdańsk, Poland, 2Medical University of Gdańsk, Department of Pediatrics, Endocrinology and Diabetology, Gdańsk, Poland.
P.B.08.12
Anti-diabetic properties of compound a, a selective glucocorticoid receptor agonist
M. Vujicic, T. Saksida, I. Nikolic, I. Stojanovic, S. Stosic-Grujicic;
Institute for Biological Research “Sinisa Stankovic”, University of Belgrade, Belgrade, Serbia.
P.B.08.14 Anti-citrullinated protein antibody binding profile to Fc gamma receptors
A. C. Kempers1, M. R. Nejadnik2, Y. Rombouts1,3, W. Jiskoot2, T. W. Huizinga1, R. E. Toes1, H. U. Scherer1;
LUMC, Leiden, Netherlands, 2LACDR, Leiden, Netherlands, 3CNRS UMR 8576, Villeneuve d’Ascq, France.
1
P.B.08.15
the effect of il-23 levels on clinical and laboratory parameters of patients with ankylosing spondylitis
B. Elbey1, U. C. Yazgan2, M. A. Sarıyıldız3;
1
Dicle Univercity, Faculty of Medicine,Department of Immunology, Diyarbakir, Turkey, 2Dicle Univercity, Faculty of Medicine,Department of Physiology,, Diyarbakir, Turkey, 3Dicle Univercity, Faculty of
Medicine,Department of Physical medicine and rehabilitation, Diyarbakir, Turkey.
P.B.08.16 Anti-dsDNA and anti -C1q autoantibodies in lupus nephritis
S. Blazickova1,2, I. Stiborova3, V. Kral3, J. Rovensky4;
1
Laboratoria Piestany, Piestany, Slovakia, 2Faculty of Health and Social Work, University of Trnava, Trnava, Slovakia, 3Centre of Immunology and Microbiology, Institute of Public Health, Usti nad Labem,
Czech Republic, 4National Institute of Rheumatology, Piestany, Slovakia.
P.B.08.17
Immunodiagnostic Significance of anti-RA33 antibodies in Saudi Patients with Rheumatoid Arthritis
J. A. Al-Mughales;
Department of Microbiology and Immunology; Faculty of medicineKingabdulaziz University, Jeddah, Saudi Arabia.
P.B.08.18 Induction of joint-associated myeloid lineage cells by chronic inflammation in collagen induced arthritis
D. Flegar, N. Kovacic, T. Kelava, A. Sucur, K. Zrinski Petrovic, S. Ivcevic, A. Markotic, V. Katavic, D. Grcevic;
University of Zagreb School of Medicine, Zagreb, Croatia.
P.B.08.19 Differential anti-inflammatory effects of omega unsaturated fatty acids on collagen-induced arthritis in the mouse
P. Pérez-Martínez, P. Arce-Paredes, V. G. Hernández-Chávez, O. Rojas-Espinosa;
Instituto Politécnico Nacional, México, D.F, Mexico.
P.B.08.20
The role of autoantibodies in microvascular disease in Systemic Sclerosis (SS) patients
P.B.08.21
The comparison two educational methods (based on Empowerrment model) on knowledge and metabolic control of patients with diabetes mellitus type 2
P.B.08.22
A study of dietary intervention in rheumatoid arthritis patients with stable disease receiving anti-TNF alpha therapy
I. Gkougkourelas, A. Sarantopoulos, K. Tselios, M. Pantoura, P. Boura;
Hippokration General Hospital, Thessaloniki, Greece.
S. Pedramrazi1, M. Sadeghi2;
1
Tehran University Of Medical Science, Tehran, Iran, Islamic Republic of, 2Shahrood University Of Medical Science, Shahrood, Iran, Islamic Republic of.
R. Paganelli, P. Volpe, M. D’Urbano, E. Celletti, M. Guagnano;
Dept. of Medicine and Sciences of Aging, University “G. D’Annunzio” and Ce.S.I, Chieti scalo, Italy.
P.B.09 (Chronic) Inflammatory Joint Diseases - Part 1
Chairpersons: Lars Klareskog; Stockholm, Sweden / Dagmar Scheel-Toellner; Birmingham, United Kingdom
P.B.09.01
New microRNAs induced by AhR activation in Th17 cells implicated in arthritis
P.B.09.02
Resident monocytes are critically important for tissue destruction in arthritis
P.B.09.03
HLA-G, E and F polymorphisms and rheumatoid arthritis: Are there links ?
P. B. Donate, K. A. De Lima, J. Talbot, R. S. Peres, D. C. Nascimento, R. D. Oliveira, S. L. Almeida, J. C. Alves-Filho, T. M. Cunha, P. Louzada-Junior, F. Q. Cunha;
School of Medicine of Ribeirão Preto, Center of Research in Inflammatory Diseases (CRID), University of São Paulo, Ribeirão Preto, Brazil.
A. Puchner, V. Saferding, E. Goncalves-Alves, M. Bonelli, N. Binder, C. Steiner, S. Hayer, B. Niederreiter, J. S. Smolen, K. Redlich, S. Blüml;
H. Ben Yahia1, L. Ben Othmane2, A. Laaribi1, A. Bouaziz3, H. Tlili4, B. Charfeddine2, I. Zidi1;
1
Laboratory Microorganismes et Biomolécules Actives, Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia, 2Biochemistry department, Faculty of Medicine of Sousse, Sousse, Tunisia, 3Ecole
supérieure des Sciences et Techniques de la Santé de Sousse, Sousse, Tunisia, 4Groupement de sante de base, Sousse, Tunisia.
P.B.09.04 Chemokines and their receptors on osteoclast progenitor cells are involved in pathogenesis in rheumatoid arthritis
A. Sucur, Z. Jajic, M. Artukovic, A. Stipic Markovic, S. Ivcevic, D. Flegar, T. Kelava, V. Katavic, N. Kovacic, D. Grcevic;
University of Zagreb School of Medicine, Zagreb, Croatia.
P.B.09.05
24
Osteoclastogenic potential of blood and bone marrow plasma from rheumatoid arthritis and osteoarthritis patients
A. Radzikowska1, M. Plebanczyk1, W. Kurowska1, T. Burakowski1, A. Nowakowska-Plaza2, P. Maldyk3, P. Gluszko2, W. Maslinski1;
1
Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland, 2Rheumatology Clinic, Institute of Rheumatology, Warsaw, Poland, 3Rheumoorthopaedic Clinic, Institute of
Rheumatology, Warsaw, Poland.
P.B.09.06 Increased levels of peptidylarginine deiminase 2 (PAD2) in plasma and synovial fluid from rheumatoid arthritis patients: Association with disease activity and
inflammatory markers
D. Damgaard1,2, L. Senolt3, C. H. Nielsen1,2;
1
Institute for Inflammation Research, Department of Infectious Diseases and Rheumatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Denmark, 2Section for
Periodontology, Microbiology and Community Dentistry, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Copenhagen, Denmark,
3
Institute of Rheumatology and Clinic of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Czech Republic, Prague, Czech Republic.
Periodontal disease in subjects with risk to develop Rheumatoid Arthritis
J. Bello-Gualtero1, L. Hoyos G2, D. Castillo2, G. Lafaurie2, J. De Avila2, J. Londoño3, R. Valle-Oñate3, C. Romero-Sánchez4,5;
1
Biomab IPS, Bogotá, Colombia, 2UIBO Institute (Oral Basic Research Unit) School of Dentistry, Universidad El Bosque, Bogotá, Colombia, 3Spondyloarthropathy Group, Rheumatology Department,
Hospital Militar/Universidad de La Sabana, Bogotá, Colombia, 4Universidad Militar Nueva Granada, Bogotá, Colombia, Bogotá, Colombia, 5UIBO Institute (Oral Basic Research Unit) School of Dentistry,
Universidad El Bosque, Bogota, Colombia.
P.B.09.08 Long-term control of severe refractory polymyositis with sequential combined therapy with intravenous immunoglobulin, rituximab and mofetil mycophenolate
J. Carbone, M. Arraya, E. Fernandez-Cruz, E. Sarmiento;
Hospital General Universitario Gregorio Marañon, Madrid, Spain.
Monday
P.B.09.07
P.B.09.09 Utility of specific autoantibodies in the follow-up of rheumatoid arthritis
E. Vergara1, I. Alcalá1, C. Carrasco2, J. L. Álvarez2, J. M. Salazar2, M. Mota3, C. Rodríguez-Godoy4, D. Sanchez-Paré4, M. L. Vargas1;
1
Service of Immunology. Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain, 2Service of Rheumatology. Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain, 3Departament of
Mathematics. University of Extremadura, Badajoz, Spain, 4Service of Radiology. Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain.
P.B.09.10
Anti-CCP antibodies as a reliable marker for predicting progression to rheumatoid arthritis
P.B.09.11
Decrypting the disease specific pathways in rheumatoid arthritis, psoriatic arthritis and psoriasis using in silico strategies
P.B.09.12
Enhanced myelopoiesis in murine models of rheumatoid arthritis is linked to defects in cellular cholesterol metabolism
P.B.09.13
Role of CD4+ and CD8+ T cells and MHC class II molecules in TNF-driven arthritis
E. Pipi1, C. Tsalapaki2, S. Pomoni1, K. Soufleros1, G. Katsikas2, D. Kokkinou1, D. Kokkinou1, C. Sfontouris2, A. Tsirogianni1;
1
Immumology-Histocompatibility Dept. Evangelismos General Hospital, Athens, Greece, 2Rheumatology Dept. Evangelismos General Hospital, Athens, Greece.
P. Pushparaj1, L. A. Damiati2, S. Bahlas3;
1
D. Dragoljevic1, M. Kraakman1, D. Ngo2, A. Whillas1, G. Goldberg2, S. van Doornum3,4, I. Wicks2,4,3, M. Febbraio5, J. Chin-Dusting1,6, A. J. Murphy1,6;
1
Baker IDI Heart and Diabetes Institute, Melbourne, Australia, 2Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, 3Royal Melbourne Hospital, Melbourne, Australia, 4University of
Melbourne, Melbourne, Australia, 5Garvan Institute of Medical Research, Sydney, Australia, 6Monash University, Melbourne, Australia.
S. Trembleau, B. Meyer, B. Niederreiter, C. W. Steiner, T. Prusa, G. Steiner;
P.B.09.14 The correlation between the serum level of interleukin-6(IL-6) and rheumatoid factor(RF); interleukin-6(IL-6) and anticyclic citrullinated peptide antibodies (antiCCP) in patient with rheumatoid arthritis(RA)
E. Rapushi1, T. Backa(Cico)1, A. Zoto1, E. Peterla1, E. Ktona1, D. Ruci1, M. Kurti1, E. Rapushi1, A. Mitre2;
1
U.H.C.”Mother Theresa”, Tiran, Albania, 2Intermedica Diagnostic Center, Tirana, Albania, Tiran, Albania.
P.B.09.15
IFN-beta regulates the RANKL-c-Fos-IFN-beta signaling pathway in the CAIA arthritis model
D. Zhang;
Shanghai Institute of Immunology, Shanghai, China.
P.B.09.16 Suppressed diversity of survivin splicing in active rheumatoid arthritis
M. Turkkila1, K. M. Andersson1, S. Amu2, M. Brisslert1, M. C. Erlandsson1, S. Töyrä Silfverswärd1, M. I. Bokarewa1;
Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Gothenburg, Sweden, 2Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm,
Sweden.
1
P.B.09.17
Synovial fibroblasts suppress Th1, but not Th2 or Th17 cells, through tryptophan metabolism
L. Tykocinski1, A. M. Lauffer1, A. Bohnen1, S. Krienke1, T. Tretter1, I. Adam2, S. R. Mohapatra2, P. Saikali3, M. Löhning3, M. Neidhart4, S. Gay4, C. A. Opitz2, H. Lorenz1;
1
Department of Medicine V, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany, 2Brain Cancer Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany,
3
Experimental Immunology, German Rheumatism Research Centre (DRFZ), Berlin, Germany, 4Department of Rheumatology, University Hospital Zürich, Zürich, Switzerland.
P.B.09.18 Analysis of partial ZAP-70 deficiency in a murine model of rheumatoid arthritis
R. Kugyelka, K. Olasz, Z. Kohl, S. Hee Seung, O. Tarjányi, P. Németh, T. Berki, F. Boldizsár;
University of Pécs Medical School Department of Immunology and Biotechnology, Pécs, Hungary.
P.B.09.19 Limited Th17 involvement in primary Sjögren’s syndrome
T. R. Reksten1, K. A. Brokstad1, M. Eidsheim1, R. Omdal2, M. Jonsson3;
1
Broegelmann Research Laboratory, Dep. of Clinical Sciences, University of Bergen, Bergen, Norway, 2Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger,
Norway, 3Section for Oral and Maxillofacial Radiology, Department of Clinical Dentistry, University of Bergen, Bergen, Norway.
P.B.09.20
Th1-induced CD106 expression mediates leukocytes adhesion on synovial fibroblasts
P.B.09.21
Analysis of HLA-A, -B and -DRB1 variants in fibromyalgia syndrome
P.B.09.22
Vasoactive intestinal peptide (VIP) genetic variants determine VIP serum levels and could be used as a prognosis biomarker
P.B.09.23
Collagen specific T-cell repertoire in DR4+ patients identifies new biomarkers in Rheumatoid Arthritis
L. Maggi1,2, F. Margheri3, C. Luciani3, M. Capone2, A. Mazzoni2, M. Rossi2, G. Montaini2, V. Santarlasci2, F. Liotta2, L. Cosmi4, R. Cimaz5, G. Fibbi3, M. Del Rosso3, F. Annunziato2,1;
1
Regenerative Therapy Unit, AOU Careggi Hospital, Florence, Italy, 2Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy, 3Department of Experimental and Clinical
Biomedical Science, University of Florence, Florence, Italy, 4Department of Clinical and Experimental Medicine, University of Florenc, Florence, Italy, 5Anna Meyer Children’s Hospital, Florence, Italy.
L. Gimeno1, G. Salgado1, E. Novoa1, I. Legaz2, J. Bolarin1, A. Mrowiec1, P. Martinez1, S. Soriano-Diaz1, A. Bernal1, A. Bermudez-Torrente3, A. Martinez-Leon4, I. Ibernon-Caballero5, M. Muro1, M. MoyaQuiles1, J. Campillo1, A. Minguela1, R. Alvarez-Lopez1, I. Lozano6, A. Garcia-Alonso1;
1
Immunology Service-University Clinical Hospital Virgen de la Arrixaca-IMIB, El Palmar, Spain, 2Department of Social and Health Sciences, Area od legal and Forensic Medicine.University of Murcia, Murcia,
Spain, 3Rheumatology Service-University Clinical Hospital Virgen de la Arrixaca-IMIB, El Palmar, Spain, 4Medical Family Health San Andres, Murcia, Spain, 5Psychiatry Service-University Clinical Hospital
Virgen de la Arrixaca-University Clinical Hospital Virgen de la Arrixaca-IMIB, El Palmar, Spain, 6Psychistry Service-University Clinical Hospital Virgen de la Arrixaca-IMIB, El Palmar, Spain.
A. Lamana1, I. V. Seoane2, L. Rodríguez-Rodríguez3, R. Garcia-Vicuña1, Y. Juarranz2, A. M. Ortiz1, C. Martínez2, E. Tomero1, B. Fernandez-Gutierrez3, R. P. Gomariz2, I. Gonzalez-Alvaro1;
1
Servicio de Reumatología, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria la Princesa, Madrid, Spain, 2Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain,
3
Servicio de Reumatología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.
G. Di Sante1,2, B. Tolusso1, A. Fedele1, E. Gremese1, S. Alivernini1, F. Ria2, G. Ferraccioli1;
1
Institute of Rheumatology - Università Cattolica del Sacro Cuore, Rome, Italy, 2Institute of General Pathology - Università Cattolica del Sacro Cuore, Rome, Italy.
P.B.09.24 IL-17 and IL-22 secretion by CD8+ T cells in psoriatic lesions
H. Sigurgrímsdóttir1, J. H. Eysteinsdóttir2,3, J. Freysdóttir1,4, H. K. Einarsdóttir1, B. A. Agnarsson5, J. H. Ólafsson2, B. Sigurgeirsson2, B. R. Lúðvíksson1;
1
Department of Immunology, the National University Hospital of Iceland, Reykjavík, Iceland, 2Faculty of Medicine, Department of Dermatology, University of Iceland, Reykjavík, Iceland, 3Department of
Dermatology, Sahlgrenska University Hospital, Gothenburg, Sweden, 4Faculty of Medicine, University of Iceland, Reykjavík, Iceland, 5Department of Pathology, the National University Hospital of Iceland,
Reykjavík, Iceland.
P.B.10 Inflammatory Skin and Joint Diseases
Chairpersons: Liv Eidsmo; Stockholm, Sweden / Birgit Schittek; Tübingen, Germany
P.B.10.01
B cell-bound complement activation products in the diagnosis and monitoring of systemic lupus erythematosus
P.B.10.02
Abatacept inhibits recall antigen proliferation and TNF-α production in T helper lymphocytes from juvenile idiopathic arthritis patients
J. Beckmann1, N. Bartholomä2, N. Venhoff2, P. Henneke1,3, A. Janda1,3, U. Salzer2,3;
1
Centre for Paediatrics and Adolescent Medicine, University Hospital of Freiburg, Freiburg, Germany, 2Department of Rheumatology and Clinical Immunology, University Hospital of Freiburg, Freiburg,
Germany, 3Centre for Chronic Immunodeficiency, University Medical Centre Freiburg, Freiburg, Germany.
M. Capone1, L. Maggi1, R. Cimaz2, V. Santarlasci1, M. Rossi1, A. Mazzoni1, G. Montaini1, F. Liotta1, E. Maggi1, G. Simonini2, F. Annunziato1, L. Cosmi1;
1
Department of Experimental and Clinical Medicine and DENOTHE Center, University of Florence, Florence, Italy, 2Anna Meyer Children’s Hospital and University of Florence, Florence, Italy.
25
Monday
P.B.10.03
Clonal T-cell repertoire analysis of patients with ankylosing spondylitis and HLA-B27+ healthy donors
P.B.10.04
IL-22-producing group 3 innate lymphoid cells are enriched in the joints of enthesitis related arthritis patients and inversely correlate with Th17 cells
P.B.10.05
Carbamylation of self-proteins facilitates the break of tolerance at a T-cell level
P.B.10.06
The canonical Wnt signaling is involved in fibroblast-like synoviocytes transformation during rheumatoid arthritis
P.B.10.07
Entheseal-resident γδ T cells and their role in tissue remodeling
E. A. Komech1, I. V. Zvyagin1, M. V. Pogorelyy1, V. I. Nazarov1,2, A. G. Bochkova3, I. Z. Mamedov1, Y. B. Lebedev1;
1
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation, 2National Research University Higher School of Economics, Moscow, Russian Federation, 3Medical center ‘AGAT’,
Moscow, Russian Federation.
H. Lom1,2, D. Bending1, Y. Ioannou2, M. Bajaj-Elliott1, L. R. Wedderburn1,2;
1
University College London, Institute of Child Health, London, United Kingdom, 2Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom.
J. S. Dekkers, P. A. van Veelen, G. M. Janssen, T. W. Huizinga, L. A. Trouw, R. E. Toes, J. N. Stoop;
Leiden University Medical Center, Leiden, Netherlands.
L. Laadhar1, D. Elhaj Mahmoud1, N. Sassi1, M. Allouch2, M. Kallel-Sellami1, M. Hamdoun2, I. Cheour1;
1
Rheumatology Department, Immuno-Rheumatology Research Laboratory, La Rabta Hospital, Tunis, Tunisia, 2Forensics Department, Charles Nicolle Hospital, Tunis, Tunisia.
A. Reinhardt, I. Sandrock, T. Yevsa, L. Oberdörfer, R. Förster, I. Prinz;
P.B.10.08 Contribution of the Aryl hydrocarbon Receptor Repressor (AHRR) to UVB induced skin aging in vivo
P. Jäger1, J. Krutmann2, I. Förster1, H. Weighardt1;
1
LIMES Institute, Bonn, Germany, 2IUF-Leibniz Research Institute for Environmental Medicine gGmbH, Düsseldorf, Germany.
P.B.10.09
The NADPH oxidase 2 (NOX2) mediates an anti-inflammatory response to dead cell debris
P.B.10.10
Characterization of CARD18, a novel negative regulator of IL-1β in human keratinocytes and in psoriasis
P.B.10.11
Patients with active hidradenitis suppurativa show an inflammatory profile of cytokines in serum characterised by IL-6, IL-8, IL-17A and IL-12 production
P.B.10.12
Effect of eupatilin on insulin growth factor 1-induced inflammation and lipogenesis in SZ95 sebocyte
P.B.10.13
Investigating the involvement of PRINS non-coding RNA in psoriasis associated inflammatory responses of keratinocytes
J. Hahn;
UK Erlangen, Erlangen, Germany.
A. Göblös1, J. Danis1, Z. Bata-Csörgő1,2, L. Kemény1,2, M. Széll3,2;
1
University of Szeged, Department of Dermatology and Allergology, Szeged, Hungary, 2University of Szeged, Dermatological Research Group of the Hungarian Academy of Sciences, Szeged, Hungary,
3
University of Szeged, Department of Medical Genetics, Szeged, Hungary.
R. de la Varga Martínez1, D. Jiménez-Gallo2, C. Albarrán-Planelles2, M. Linares-Barrios2, C. Rodríguez1;
1
Immunology Department, Hospital Universitario Puerta del Mar, Cádiz, Spain, 2Dermatology Department, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Y. Lee, J. Lee, Y. Park;
Department of Dermatology, Seoul St.Mary’s Hospital, Seoul, Korea, Republic of.
J. Danis1, A. Göblös1, Z. Bata-Csörgő1,2, L. Kemény1,2, M. Széll3,2;
University of Szeged, Department for Dermatology and Allergology, Szeged, Hungary, 2MTA-SZTE Dermatological Research Group, Szeged, Hungary, 3University of Szeged, Department of Medical
Genetics, Szeged, Hungary.
1
P.B.10.14
Improvement of vascular dysfunction by anti-IL-17A treatment in psoriasis
P.B.10.15
Langerhans cells and infiltrating epidermal Dendritic cells produce distinct and complementary cytokines that sustain the skin inflammation in active psoriasis
P.B.10.16
Global transcriptome analysis of human keratinocytes after silencing of SFRS18 and LUC7L3 splicing regulators implicated in psoriasis pathogenesis
P.B.10.17
Expression of receptors to IL-1 on peripheral blood immunocompetent cells in atopic dermatitis
P.B.10.18
Netting neutrophils in skin wounds recruit and activate plasmacytoid dendritic cells
P.B.10.19
Recirculating Th1 and Th17 memory T cells in psoriasis and psoriatic arthritis
P.B.10.20
Development of an ex-vivo model to study properties of human tissue resident memory T cells in inflammatory skin diseases
P.B.10.21
Clinical value of concentration, rheumatoid factor activity, and immunoglobulin subtypes of cryoprecipitate in the diagnosis of cryoglobulinemic vasculitides
P.B.10.22
Huiyang shengji ointment promoted chronic wound healing of the mouse model by regulating macrophage phenotype transition
P.B.10.23
Specific roles for dendritic cell subsets during initiation and progression of psoriasis
P.B.10.24
MALT1 deficiency is not protective in mouse models of psoriasis
R. Schüler1,2, S. Karbach1,2, S. Klebow2, P. Wenzel1, A. Waisman2;
1
II. Medical Clinic, University Medical Center, Mainz, Germany, 2Institute for Molecular Medicine, University Medical Center, Mainz, Germany.
E. Martini, M. Wikén, S. Cheuk, M. Ståhle, L. Eidsmo;
Karolinska Institutet, Stockholm, Sweden.
E. Szlávicz1, P. Oláh2, K. Szabó1,3, Z. Bata-Csörgő1,3, L. Kemény1,3, M. Széll3,4;
1
University of Szeged, Department of Dermatology, Szeged, Hungary, 2University of Szeged, Department of Medical Biology, Szeged, Hungary, 3University of Szeged, MTA Dermatologic Research Group,
Szeged, Hungary, 4University of Szeged, Department of Medical Genetics, Szeged, Hungary.
A. Alshevskaya, J. Lopatnikova, O. Krugleeva, V. Nepomnyschih, S. Sennikov;
Federal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”, Novosibirsk, Russian Federation.
J. Di Domizio1, C. Belkhodja1, A. Van Lierop2, O. Demaria1, C. Conrad1, B. Homey2, M. Gilliet1;
1
University Hospital of Lausanne, Lausanne, Switzerland, 2Heinrich-Heine-University, Duesseldorf, Germany.
F. Sgambelluri1, M. Diani2, M. Longhi3, A. Altomare2, G. Banfi1,2,3, G. Altomare2, E. Reali1;
1
I.R.C.C.S. Istituto Ortopedico Galeazzi, Laboratory of Translational Immunology, Milan, Italy, 2I.R.C.C.S. Istituto Ortopedico Galeazzi, Department of Dermatology and University of Milan, Milan, Italy,
3
I.R.C.C.S. Istituto Ortopedico Galeazzi, Department of Rheumatology, Milan, Italy.
I. Gallais Sérézal, I. Gallais Sérézal, L. Eidsmo, S. Cheuk, D. Chang;
Department of Medicine Solna, Karolinska Institutet, stockholm, Sweden.
M. Kolopp Sarda1, C. Théry2, C. Lombard1, A. Millet1, J. Lega3;
1
CH Lyon Sud Lab Immunology, Pierre Benite, France, 2Internal Medicine Department , CH Lyon Sud, Pierre Benite, France, 3Internal Medicine Department, CH Lyon Sud, Pierre Benite, France.
X. He, P. Li, Y. Xue, Y. Lin;
E. Glitzner1, A. Korosec1, P. M. Brunner1, B. Drobits1, N. Amberg1, H. B. Schönthaler2, T. Kopp1, E. F. Wagner2, G. Stingl1, M. Holcmann1, M. Sibilia1;
1
Medical University of Vienna, Vienna, Austria, 2CNIO, Madrid, Spain.
E. Van Nuffel1,2, I. Afonina1,2, R. Beyaert1,2;
1
Unit of Molecular Signal Transduction in Inflammation, Inflammation Research Center, VIB, Ghent, Belgium, 2Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
P.B.11 Allergen Specific Immune Responses - Part 1
Chairpersons: Gunnur Deniz; Istanbul, Turkey / Karin Hoffmann-Sommergruber; Vienna, Austria
26
P.B.11.01
Analysis of recombinant Gly m 4 allergen multimer formation in dependency to pH
P.B.11.02
Allergenicity change of bovine α-lactalbumin by gamma irradiation
P.B.11.03
Safety assessment of nanoparticle and allergen conjugates: enhanced human allergic response when Der p 1 was attached to nanoparticles
H. Havenith, S. Rasche, H. Spiegel, S. Schillberg;
Fraunhofer IME, Aachen, Germany.
X. Li1,2,3, X. Meng2,3, H. Chen2,3, J. Gao2,3, P. Tong2,3, Z. Wu2,3, A. Yang2;
1
Department of Molecular Biology,University of Salzburg, Salzburg, Austria, 2State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China, 3Department of food sciences,
Nanchang University, Nanchang, China.
I. Radauer-Preiml1, A. Andosch1, M. Himly1, S. Flicker2, S. Vrtala2, T. Hawranek3, U. Luetz-Meindl1, C. Huber1, M. S. Boyles1, J. Horejs-Hoeck1, A. Duschl1;
1
Department of Molecular Biology, University of Salzburg, Salzburg, Austria, 2Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Vienna,
Austria, 3Department of Dermatology, Paracelsus Medical University, Salzburg, Austria.
P.B.11.04
IgE epitope proximity determines immune complex shape and effector cell activation capacity
P.B.11.05
Prospective follow-up venom inmunotherapy by way of Basophil Activation Test (BAT)
P.B.11.06
House Dust Mites Possess a Polymorphic, Single Domain Putative Peptidoglycan D,L endopeptidase Belonging to the NlpC/P60 Superfamily
P.B.11.07
Allergen aggregates exhibit reduced allergenic activity due to altered presentation of IgE epitopes
P.B.11.08
Are house dust mites potential carriers of bacteria responsible for the induction of sensitization to microbial “allergens”?
P.B.11.09
LPS promotes the generation to Pru p 3 anaphylactic mouse model
P.B.11.10
Clustering of conformational IgE epitopes on the major dog allergen Can f 1
P.B.11.11
Production of the recombinant allergen Mal d 3 (apple non-specific lipid transfer protein), by using the methylotrophic yeast Pichia pastoris
P.B.11.12
Seed-specific allergens associated with severe symptoms of celery allergic patients
P.B.11.13
High allergenic activity of the house dust mite allergens Der p 5, Der p 7, Der p 21 and Der p 23 shown by basophil activation in HDM-allergic patients
P.B.11.14
fine mapping of the immunodominant IgE binding epitopes of Der p 5 Allergen: a major linear epitope formed by aromatic and hydrophobic residues
P.B.11.15
Phase 1 study of phosphatidylinositol 3-kinase delta inhibitor idelalisib in allergic rhinitis
P.B.11.16
Differences in molecular sensitization profiles of patients with severe and moderate atopic dermatitis
P.B.11.17
Reduction in allergen-specific IgE binding as measured by microarray: A possible surrogate marker for effects of specific immunotherapy
P.B.11.18
The lipocalin milk allergen Bos d 5 is capable of binding cortisol - iron complexes released by macrophages
I. Magriz Tascón1, C. Cámara Hijón1, A. Rodriguez Trabado2, E. Madany1, S. Romero Chala1, J. García Trujillo1, I. Tovar García1, L. Fernández Pereira1;
1
San Pedro de Alcántara Hospital, Cáceres, Spain, 2Ciudad de Coria Hospital, Coria, Spain.
G. A. Stewart, V. H. Tang, B. J. Chang, C. Y. Tay;
University of Western Australia, Perth, Australia.
N. Najafi1, G. Hofer2, K. Blatt3, A. Stoecklinger4, W. Keller2, P. Valent3, J. Thalhamer4, R. Valenta1, S. Flicker1;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Institute
of Molecular Biosciences, University of Graz, Graz, Austria, 3Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria, 4Department of
Molecular Biology, University of Salzburg, Salzburg, Austria.
Monday
A. Gieras1, B. Linhart1, K. Roux2, M. Dutta2, M. Khodoun3, D. Zafred4, C. R. Cabauatan1, C. Lupinek1, M. Weber1, M. Focke-Tejkl1, W. Keller4, F. D. Finkelman3, R. Valenta1;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna, Austria, 2Department
of Biological Science and Institute of Molecular Biophysics, The Florida State University, Tallahassee, FL, United States, 3Department of Medicine, Cincinnati Veterans Affairs Medical Center; the Division of
Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine; and the Division of Cellular and Immunobiology, Cincinnati Children’s Hospital Medical, Cincinnati, OH, United States,
4
Division of Structural Biology, Institute of Molecular Biosciences, Karl Franzens University of Graz, Graz, Austria.
S. Dzoro1, I. Mittermann1, M. Nehr2, A. Hirschl2, G. Wikberg3, C. Johansson4, L. Lundeberg3, A. Scheynius4, R. Valenta1;
1
Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria, 2Division of Clinical Microbiology, Clinical Institute of Laboratory Medicine, Medical University of
Vienna, Vienna, Austria, 3Dermatology and Venereology Unit, Karolinska University Hospital, Stockholm, Sweden, 4Translational Immunology Unit, Department of Medicine, Solna, Karolinska Institutet and
Karolinska University Hospital, Stockholm, Sweden.
C. Mayorga1,2, A. Aranda3, M. Rodriguez3, T. Fernandez3, N. Cubells-Baeza4, M. Torres5, F. Gomez5, F. Palomares1, J. Rojo6, M. Blanca5, A. Diaz-Perales4;
1
Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain, Málaga, Spain, 2Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain, 3Research
Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain, Malaga, Spain, 4Center for Plant Biotechnology and Genomic (UPM-INIA), Madrid, Spain, 5Allergy Unit, IBIMA, Regional
University Hospital of Malaga, UMA, Málaga, Spain, 64Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Sevilla, Spain.
M. Curin1, M. Weber1, G. Hofer2, W. Keller2, M. Focke-Tejkl1, R. Valenta1;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Institute of
Molecular Biosciences, University of Graz, Graz, Austria.
R. Aina, S. Pfeifer, P. Dubiela, P. Humeniuk, K. Hoffmann-Sommergruber;
Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
P. P. Humeniuk1, P. Dubiela1, S. Pfeifer1, M. Bublin1, F. Bienvenu2, G. Pauli2, K. Hoffmann-Sommergruber1;
1
Department of Pathophysiology and Allergy Research, Vienna, Austria, 2Faculty of Medicine, Strasbourg University, Strasbourg, France.
Y. Resch1, M. Šilar2, P. Kopač2, M. Zidarn2, K. Chen1, W. Thomas3, P. Korošec2, M. Košnik2, R. Valenta1, S. Vrtala1,4;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2University
Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia, 3Telethon Institute for Child Health Research, University of Western Australia, Perth, Australia, 4Christian Doppler Laboratory for the
Development of Allergen Chips, Medical University of Vienna, Vienna, Austria.
S. Lahiani1,2, S. Khemili1,3, K. Djenouhat4, m. dumez5, d. Gilis3, m. galleni5;
1
Avenuedel’indipendance, Boumerdes, Algeria, 2Centre d’ingénierie des protéines (CIP), Université de Liège, Belgium, Liege, Belgium, 3Unité de Bioinformatiquegénomiqueetstructurale, UniversitéLibre de
Bruxelles, Belgium., Bruxelle, Belgium, 4institut pasteur, alger, Algeria, 5Centre d’ingénierie des protéines (CIP), Université de Liège, Belgium, Université de Liège, Belgium.
R. Schmutz1, P. Zieglmayer1, F. Horak1, K. Puri2, B. Steiner2, L. Holes2, G. Xing2, R. Zieglmayer3, P. Lemell3, A. Yu2;
1
Vienna Challenge Chamber, Allergy Center Vienna West, Vienna, Austria, 2Gilead Sciences, Inc, Seattle, WA, United States, 3Vienna Challenge Chamber, Vienna, Austria.
I. Mittermann1, G. Wikberg2, C. Johansson3, C. Lupinek4, L. Lundeberg3, R. Crameri5, R. Valenta6, A. Scheynius3;
1
Christian Doppler Laboratory for the Development of Allergen Chips, Medical University of Vienna, Vienna, Austria, 2Dermatology and Venereology Unit, Karolinska University Hospital, Stockholm,
Sweden, 3Translational Immunology Unit, Department of Medicine, Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, 4Division of Immunopathology, Department of
Pathophysiology and Allergy Research, Vienna, Austria, 5Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland, 6Division of Immunopathology, Department of
Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
E. Wollmann1, C. Lupinek1, M. Kundi2, R. Selb3, V. Niederberger3, R. Valenta1;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Institute of
Environmental Health, Center of Public Health, Medical University of Vienna, Vienna, Austria, 3Department of Ear, Nose and Throat Diseases, Medical University of Vienna, Vienna, Austria.
F. Roth-Walter1, R. Bianchini1, H. Müller1, L. F. Pacios2, K. Hufnagl1, L. Glenk1, R. Palme3, N. Mothes-Luksch4, G. Roth5, E. Jensen-Jarolim1,6;
Dept. of Comparative Medicine, Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria, 2Department of Natural Systems
and Resources, ETSI Montes, Technical University Madrid, Madrid, Spain, 3Unit of Physiology, Pathophysiology and Experimental Endocrinology, University of Veterinary Medicine Vienna, Vienna, Austria,
4
AllergyCare, Allergy Diagnosis and Study Center, Vienna, Austria, 5Department of Anesthesiology, General Intensive Care and Pain Medicine, Medical University of Vienna, Vienna, Austria, 6Department of
Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
1
P.B.11.19
Creation of a 4-level International Educational Process on Molecular Allergology: Experience of the Medical University of Vienna
P.B.11.20
Allergenic potential of canned cod liver due to the presence of Anisakis L3
P.B.11.21
Generation of a hypoallergenic variant of Phl p 7 by mutagenesis of specific amino acids involved in calcium binding
P.B.11.22
Identification and characterisation of the muscle protein myosin light chain 1 as a major chicken meat allergen
V. Garib, R. Valenta;
Div. of Immunopathology, Dept. of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
M. Carballeda Sangiao1, A. I. Rodríguez-Mahillo1, M. Careche2, A. Navas3, K. Buchmann4, K. Horst5, M. González-Muñoz6;
1
Foundation for Biomedical Research Hospital La Paz, Paseo de la Castellana, Madrid, Spain, 2Institute of Science and Technology Food and Nutrition (ICTAN), CSIC, Madrid, Spain, 3Museum of Natural
Sciences (MNCN), CSIC, Madrid, Spain, 4University of Copenhagen (OUC), Faculty of Medicine and Health, Copenhagen, Denmark, 5Max Rubner Institute. Department of Safety and Quality of Milk and
Fish, Hamburg, Germany, 6Service of Immunology, Hospital La Paz, Paseo de la Castellana, Madrid, Spain.
M. Raith1, L. Sonnleitner1,2, D. Zach1, K. Woroszylo1, M. Focke3, H. Wank1, I. Swoboda1;
1
FH Campus Wien, University of Applied Sciences, Molecular Biotechnology Section, Vienna, Austria, 2University of Applied Sciences Wiener Neustadt, Department of Biomedical Analytics, Wiener Neustadt,
Austria, 3Medical University of Vienna, Division of Immunopathology, Department of Pathophysiology and Allergy Research, Vienna, Austria.
C. Klug1, W. Hemmer2, M. Focke3, S. Quirce4, T. Boyano-Martínez4, E. Gaubitzer5, H. Wank1, I. Swoboda1;
Molecular Biotechnology Section, University of Applied Sciences FH Campus Wien, Vienna, Austria, 2FAZ- Floridsdorf Allergy Center, Vienna, Austria, 3Division of Immunopathology, Department of
Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 4Department of Allergy, Hospital La Paz Health Research
Institute (IdiPAZ), Madrid, Spain, 5Department of Biochemistry & Biophysics, Structural & Computational Biology, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.
1
Chairpersons: Zolt Szepfalusi; Vienna, Austria / Carsten Schmidt-Weber; Munich, Germany
P.B.12.01
Role of α-MSH and VIP in the induction of CD4+ CD25+ FOXP3+ cells in allergic conjuntivitis patients
J. Galicia-Carreón1, L. Salazar2, J. Nieto2, S. Fest2, E. Hong1, M. Pérez-Tapia3, M. Jiménez-Martinez4;
1
Cinvestav, Mexico City, Mexico, 2Instituto de Oftalmología Fundación Conde de Valenciana., Mexico City, Mexico, 3Escuela Nacional de Ciencias Biológicas del I.P.N., Mexico City, Mexico, 4Laboratorio de
Inmunología Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México., Mexico City, Mexico.
27
Monday
P.B.12.02
Prevention of anaphylaxis by antigen-specific immunosuppressive sialylated IgG antibodies
P.B.12.03
Decoding the molecular mechanisms associated with allergic asthma using functional genomics and systems biology
P.B.12.04
Targeting hematopoietic cells is not essential for glucocorticoid therapy in a murine model of allergic asthma
P.B.12.05
PARP is activated in human asthma and its inhibition blocks asthma manifestation in achronic house dust mite based preclinical asthma model and selectively
modulates human CD4+T cell function
A. Epp1, F. Finkelman2, M. Ehlers1;
1
Universitätsklinikum Schleswig-Holstein, Lübeck, Germany, 2Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States.
P. Pushparaj1, L. A. Damiati2, S. Bahlas3;
1
C. Klaßen, A. Karabinskaya, H. M. Reichardt;
Institute for Cellular and Molecular Immunology, University of Göttingen, Göttingen, Germany.
M. A. Ghonim, K. Pyakurel, S. Ibba, J. Wang, P. Rodriguez, M. Lammi, A. Zea, A. Naura, H. A. Boulares;
Louisiana State University Health Sciences Center, new orleans, LA, United States.
P.B.12.06
Mast cell protease expression is affected by stress and cholinergic signaling
P.B.12.07
Farm dust extract increases the epithelial barrier function of human bronchial epithelial cells
P.B.12.08
A severe drug hypersensitivity case with ulcerative colitis and the value of in vitro diagnostic test
P.B.12.09
Reduction of blood basophil numbers and high affinity IgE receptor expression during anaphylaxis
P.B.12.10
Contact hypersensitivity to dinitrochlorobenzene induces systemic immunomodulatory effects that are strain-dependent
P.B.12.11
A low expression of Tim3 is found in skin and peripheral blood from Patients with cutaneous non-immediate hypersensitivity reactions to drugs during the acute
phase of the reaction
F. R. Rommel1, B. Raghavan1, S. Tumala1, S. Laux1, J. Kruse2, U. Gieler2, E. M. Peters3,1;
1
Psychoneuroimmunologie Labor, Klinik für Psychosomatik und Psychotherapie, Justus Liebig Universität Gießen, Ludwigstr. 78, 35392 Gießen, Gießen, Germany, 2Klinik für Psychosomatik und
Psychotherapie, Justus Liebig Universität Gießen, Friedrichstr. 123, 35392, Gießen, Germany, 3CharitéCentrum 12 (CC12) für Innere Medizin und Dermatologie, Charité Platz 1, 10117 Berlin, Berlin, Germany.
L. E. P. van der Vlugt1, K. Eger1, G. D. Amatngalim1, C. Müller2, F. Bracher2, E. von Mutius2, H. H. Smits1, P. S. Hiemstra1;
1
Leiden University Medical Center, Leiden, Netherlands, 2Ludwig-Maximilians University, Munchen, Germany.
N. Akdeniz1, L. P. Ozyigit2,1, E. A. Cetin1, U. C. Kucuksezer1, R. Iliaz3, Z. Mungan2, G. Deniz1;
1
Istanbul University, The Institute of Experimental Medicine (DETAE),Department of Immunology, Istanbul, Turkey, 2Koc University, School of Medicine, Istanbul, Turkey, 3Istanbul University, Istanbul
Medical Faculty, Department of Internal Medicine, Istanbul, Turkey.
M. Rijavec, M. Šilar, P. Kopač, M. Košnik, P. Korošec;
University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.
A. Popov Aleksandrov1, I. Mirkov1, J. Demenesku1, M. Ninkov1, D. Mileusnic1, J. Jovanovic1, D. Kataranovski1,2, M. Kataranovski1,3;
1
Institute for Biological Research “Sinisa Stankovic”, Belgrade, Serbia, 2Institute of Zoology,Faculty of Biology, University of Belgrade, Belgrade, Serbia, 3Institute of Physiology and Biochemistry, Faculty of
Biology, University of Belgrade, Belgrade, Serbia.
T. D. Fernandez1, F. Palomares1, A. Ariza1, I. Doña2, M. Salas2, M. Blanca2, M. J. Torres2, C. Mayorga1;
1
Research Laboratory-Allergy Unit. IBIMA-Regional University Hospital of Malaga, Malaga, Spain, 2Allergy Service. IBIMA-Regional University Hospital of Malaga, Malaga, Spain.
P.B.12.12
Hydrogen Sulphide (H2S) modulates apoptosis process and cytokines levels in allergic lung inflammation
P.B.12.13
Role of mucosal immunity in allergic rhinitis phenotype formation
P.B.12.14
the prognostic value of the neutrophil / lymphocyte ratio in patients with snake bites for clinical outcomes and complications
H. H. A. Ferreira1, J. A. Pereira2, C. Lanaro3, N. Conran3, T. Rocha2;
1
São Leopoldo Mandic Institute and Research Center, Campinas, Brazil, 2São Francisco University, Bragança Paulista, Brazil, 3State University of Campinas - UNICAMP, Campinas, Brazil.
B. Sangidorj, N. Tataurshchikova;
Peoples’ Friendship University of Russia, Moscow, Russian Federation.
B. Elbey1, u. c. yazgan2, y. zengin3;
1
Dicle Univercity, Faculty of Medicine,Department of Immunology, Diyarbakir, Turkey, 2Dicle Univercity, Faculty of Medicine,Department of Physiology,, diyarbakir, Turkey, 3Dicle Univercity, Faculty of
Medicine,Department of Emergency Medicine, diyarbakir, Turkey.
Chairpersons: Wiebke Hansen; Essen, Germany / Miodrag Colic; Belgrade, Serbia
P.B.13.01
Fibronectin production in basal-like breast cancer cells is regulated by pro-inflammatory cytokines and may influence myeloId cell maturation
P.B.13.02
Effects of Some Natural Immunomodulatory Compounds in Combination with Thalidomide on Survival Rate and Tumor Size in Fibrosarcoma-Bearing Mice
P.B.13.03
Suppression of T-cell-mediated immune responses and the role of Foxp3+ regulatory T cells in a murine model of spontaneously arising B-cell lymphoma
P.B.13.04
Prognostic impact of platalet/lymphocyte and neutrophil/lymphocyte ratios in patients with gastric cancer: A multicenter study
P.B.13.05
Temozolomide sensitizes glioblastoma cells towards γδ T cell-mediated killing
P.B.13.06
Defined immune phenotypes in patients with glioblastoma multiforme are associated with survival
P.B.13.07
Modeling of the Mechanism of Glucocorticoid Resistance Using CRISPR/Cas9 Mediated Genome Editing
P.B.13.08
HCC-induced myeloid derived suppressor cells alter Kupffer cell function
G. Tunali, G. Esendagli;
Hacettepe University Cancer Institute, Ankara, Turkey.
R. Aghebati Maleki, B. Baradaran, L. Aghebati Maleki, N. Ftoohi;
Immunology, tabriz, Iran, Islamic Republic of.
F. Ahmetlić1, T. Riedel1, T. Sparwasser2, M. Röcken3, R. Mocikat1;
1
Institut für Molekulare Immunologie, Helmholtz-Zentrum München- Deutsches Zentrum für Gesundheit und Umwelt, Munich, Germany, 2Institut für Infektionsimmunologie, Twincore GmbH, Hannover,
Germany, 3Universitäts-Hautklinik, Eberhard-Karls-Universität, Tübingen, Germany.
M. Gunaldi1, S. Goksu2, S. Gunduz3, Y. Okuturlar1, E. Tiken1, S. Kahraman1, N. Isiksacan1;
1
Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey, 2Kayseri Training and Research Hospital, Kayseri, Turkey, 3Antalya Training and Research Hospital, Antalya, Turkey.
G. Chitadze1, M. Lettau1, S. Lücke1, O. Janssen1, D. Wesch1, H. Oberg1, J. Held-Feindt2, D. Kabelitz1;
1
Institute of Immunology, kiel, Germany, 2Department of Neurosurgery, University Medical Center Schleswig-Holstein UKSH, Campus Kiel, kiel, Germany.
H. Mostafa1, E. Dietrich1, A. Pala2, C. Wirtz2, M. Schneider1;
1
Section Experimental Anesthesiology, University Hospital Ulm, Ulm, Germany, 2Department of Neurosurgery, University Hospital Ulm and Bezirkskrankenhaus Günzburg, Ulm, Germany.
A. Ozcan, B. Erman;
Sabanci University, Faculty of Engineering and Natural Sciences, Molecular Biology, Genetics and Bioengineering Program, Istanbul, Turkey.
S. Lacotte1, F. Slits1, L. Orci1, C. Gonelle-Gispert2, G. Oldani1, P. Morel2, C. Toso1;
Hepatology and Transplantation Laboratory, Genève 4, Switzerland, 2Surgical Research Laboratory, Genève 4, Switzerland.
1
P.B.13.09
Effects of PI3K/Akt/mTOR inhibitors on expression of IL-8 and CXCR1 in HER2+ breast cancer cells
P.B.13.10
Evaluation of immunological factors in peritoneal fluid and peripheral blood in ovarian and colorectal cancer with peritoneal carcinomatosis treated with HIPEC
(Hyperthermic Intraperitoneal Chemotherapy)
B. Sirin, M. E. Gedik, E. Kansu, A. L. Dogan;
Cancer, Ankara, Turkey.
E. Villegas1,2, C. Martínez-García1, J. Pons1,2, Á. Molina1,2, N. Esteve3,2, R. Morales4,2, J. Milà1,2;
1
Immunology Service. Hospital Universitario Son Espases, Palma de Mallorca, Spain, 2Institut d’Investigació Sanitària de Palma (IdISPa), Palma de Mallorca, Spain, 3Anesthesia Service. Hospital
Universitario Son Espases, Palma de Mallorca, Spain, 4Digestive Surgery Service. Hospital Universitario Son Espases, Palma de Mallorca, Spain.
P.B.13.11
28
Recombinant tandem expression and antitumor activity of human IL-2 and TNF-alpha
W. Qi, Y. Li, W. Shi, A. Yu;
Institute of Pathogen Biology, Taian, China.
P.B.13.12
The alarmin IL-33 is expressed in breast cancer : an emerging role in breast cancer immunity
E. Blanc1, C. Le Beux1, N. Vey1, A. Colombe2, A. Morel1, C. Dezutter-Dambuyant1, P. Saintigny1, I. Treilleux1, C. Caux1, N. Bendriss-Vermare1;
Cancer Research Center of Lyon, Lyon, France, 2Centre Leon Berard, Lyon, France.
P.B.13.13
Immune-dependent antineoplastic effects of cisplatin plus pyridoxine in non-small-cell lung cancer
P.B.13.14
A polyphenolic fraction from Caesalpinia spinosa induces immunogenic cell death and enhances tumor control through the activation of the immune system
P.B.13.15
Characterization and specificity analysis of tumor infiltrating lymphocytes in ovarian carcinoma
P.B.13.16
Impact of Interleukin-22 on two murine models of lung and breast cancer
P.B.13.17
Establishment and characterization of a new cell line of leukaemia: BML01
P.B.13.18
Tumor lymphangiogenesis in mouse and human melanoma: New roles in immunomodulation
P.B.13.19
B16F10-melanoma cells modulate effector functions of mast cells via the inhibitory gp49B-receptor
P.B.13.20
Production of interleukin 17 correlates with radioiodine-induced micronuclei frequency in patients with papillary thyroid cancer
P.B.13.21
MicroRNA-155 is upregulated in the tumor infiltrating T cells and promotes the accumulation of CD8+ T-cells for immunotherapy of cancer.
P.B.13.22
Mesenchymal stromal cells derived from cervical cancer (MSC-CeCa) favor the tumor growth and inhibit antitumor immune response in a mice model through
CD73 pathway
F. Aranda1,2, N. Bloy1,2,3, O. Kepp1,2, C. Pfirschke4, M. Pittet4, L. Zitvogel3,5,6, G. Kroemer1,7,8, L. Senovilla1,2;
1
Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, INSERM U1138, Paris, France, 2Gustave Roussy, Villejuif, France, 3Universitè Paris Sud, Villejuif, France,
4
Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States, 5INSERM U1015, Villejuif, France, 6Centre dÍnvestigation Clinique Biothérapie CIBT 507,
Villejuif, France, 7Université Paris Descartes, Paris, France, 8Metabolomics and Cell Biology Platforms, Villejuif, France.
A. Gomez Cadena1, C. P. Urueña1, A. Martinez-Usatorre2, A. Barreto1, P. Romero2, S. Fiorentino1;
1
Grupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Bogota, Colombia, 2Ludwig Cancer Research Center, University of Lausanne, Lausanne, Switzerland.
K. Röhle1, H. Schuster1, J. Peper1, P. Wagner2, H. Rammensee1, S. Stevanović1;
1
Interfaculty Institute for Cell Biology, Department of Immunology, Tübingen, Germany, 2Department of Obstetrics and Gynecology, University Hospital Tübingen, Tübingen, Germany.
Monday
1
C. Ochs, P. May, D. Wenk, S. Endres, S. Kobold;
Division of Clinical Pharmacology, Department of Internal Medicine IV, Ludwig-Maximilians Universität, Munich, Germany.
B. Tsai1, J. Tang2, C. Li2, C. Lin2, B. Chiang3;
1
NAVI Bio-therapeutics. Inc., Kaohsiung, Taiwan, 2Tai Cheng Stem Cell Therapy Center , National Taiwan University, Taipei, Taiwan, 3Department of Pediatrics, National Taiwan University Hospital, College of
Medicine, National Taiwan University, Taipei, Taiwan.
M. Broggi1, M. Fankhauser1, N. Bordry2, S. Wullschleger3, K. Homicsko3, D. Hanahan3, D. Speiser2, M. Swartz1,4;
1
Laboratory for Lymphatic and Cancer Bioengineering, EPFL, Lausanne, Switzerland, 2Clinical Tumor Biology and Immunotherapy Group, Department of Oncology and Ludwig Cancer Research, University
Lausanne, Lausanne, Switzerland, 3The Swiss Institute for Experimental Cancer Research, EPFL, Lausanne, Switzerland, 4Institute for Molecular Engineering, University of Chicago, Chicago, IL, United
States.
S. Dietzen, T. Brühl, N. Stergiou, T. Bohn, A. Ulges, M. Klein, E. Schmitt, T. Bopp;
Institute of Immunology, Mainz, Germany.
S. Zivancevic-Simonovic1, O. Mihaljevic1, P. Djurdjevic1, I. Majstorovic2, O. Milosevic-Djordjevic1, I. Kostic1, L. Mijatovic-Teodorovic1;
1
Faculty of Medical Sciences, Kragujevac, Kragujevac, Serbia, 2Institute for Medical Research, Military Medical Academy, Belgrade, Serbia.
A. Martinez Usatorre1, C. Jandus1, D. E. Speiser1, J. C. Dudda1, P. Foukas2, P. Romero1;
1
Ludwig Cancer Research - University of Lausanne, Epalinges, Switzerland, 2Department of Oncology, Lausanne University Hospital Center (CHUV), Lausanne, Switzerland.
C. A. Montoro1, A. Monroy2, J. Hernández1, B. Weiss1, M. L. Mora1;
1
Immunobiology laboratory, UIDCC UMIEZ, FES Zaragoza UNAM, Mexico City, Mexico, 2Immunology and cancer laboratory, UIMEO, H Oncología CMN SXXI IMSS, Mexico City, Mexico.
P.B.13.23
High Frequency of Peripheral Foxp3 Regulatory T cells in Cervical Cancer patients in KwaZulu-Natal, South Africa
P.B.13.24
Dendritic cell activation following treatment with conditioned media from oesophageal tumour explants
P.B.13.25
Helper and cytotoxic T cell subsets (Th1, Th2, Tc1 and Tc2) in benign and malignant salivary gland tumors
D. Sebastian1, A. G. Assounga1,2;
1
University of KwaZulu-Natal, Durban, South Africa, 2Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
M. Morrissey1, R. Dunne1, M. Dunne1, J. Reynolds1,2, J. O’Sullivan1;
1
Trinity College Dublin, Dublin, Ireland, 2St James’ Hospital, Dublin, Ireland.
M. R. Haghshenas1, B. Khademi2, S. Rezaeifard1, N. Nazari1, A. Ghaderi1, N. Erfani1;
1
Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, shiraz, Iran, Islamic Republic of, 2Department of Otolaryngology, Khalili Hospital,
Shiraz University of Medical Sciences, shiraz, Iran, Islamic Republic of.
P.B.14 Tumorantigens and Tumorstroma
Chairpersons: Adelheid Cerwenka; Heidelberg, Germany / Ignacio J. Melero; Pamplona, Spain
P.B.14.01
Effects of resveratrol treatment on angiogenic profile in human tumor breast cells
P.B.14.02
A33scFv-Fc antibody-based imaging of subcutaneous and orthotopic xenografts of GPA33-positive colorectal cancer in mice
P.B.14.03
Coordinated interplay between EGFR/HER/ErbB tumor antigens and tumor promoting fatty acid biosynthesis provide a rich source of therapeutic targets in
ovarian cancer
C. Hotnog1, M. A. Mihaila1, M. Bostan1, M. I. Gruia2, L. I. Brasoveanu1;
1
Institute of Virology, Bucharest, Romania, 2Institute of Oncology, Bucharest, Romania.
Q. Fan, D. Wei, H. Yang, H. Cai, L. Wan, X. Lu;
West China Hospital, Sichuan University, Chengdu, China.
T. W. Grunt, R. Wagner, W. Shabbir, K. Pröstling;
Medical University Vienna, Comprehensive Cancer Center, Department of Medicine I, Division of Oncology, Vienna, Austria.
P.B.14.04
Downregulation of GFRα1 promotes HCC progression though Epithelial-to-Mesenchymal Transition
P.B.14.05
Mass spectrometric analysis of the soluble HLA peptidome from melanoma patients’ sera reveals melanoma-associated antigens
Q. Liu;
National Key Laboratory of Medical Immunology & Institute of Immunology, Shanghai, China.
D. Ritz1, A. Gloger2, B. Weide3, C. Garbe3, T. Fugmann1, D. Neri2;
1
Philochem AG, Otelfingen, Switzerland, 2Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland, 3Department of Dermatology, Division of Dermatologic Oncology, Eberhard-KarlsUniversity, Tuebingen, Germany.
P.B.14.06 OVA12, a novel tumor antigen, promotes cancer cell growth and inhibits 5-fluorouracil-induced apoptosis
L. Wang1,2, Y. Xi1,2, H. Ge1,2;
1
Shanghai Jiaotong University School of Medicine, Shanghai, China, 2Shanghai Institute of Immunology, Shanghai, China.
P.B.14.08 Mebendazole bound to HPMA copolymer carrier has dramatically improved solubility: in vitro and in vivo antitumor activity and toxicity in mice
V. Černý1, M. Studenovský2, B. Říhová1, M. Kovář1;
Institute of Microbiology, ASCR, v.v.i., Prague, Czech Republic, 2Institute of Macromolecular Chemistry, ASCR, v.v.i., Prague, Czech Republic.
1
P.B.14.09 Interleukin-21 and Interleukin-32 gene expression levels and their relationship with clinicopathologic parameters in patients with colon cancer
G. O. Erdem1, F. Ozmen1, M. M. Ozmen2,3, S. Kulacoglu4, E. Kansu1;
1
Hacettepe University Cancer Institute, Deparment of Basic Oncology, Ankara, Turkey, 2Hacettepe University Medical School,Department of Surgery, Ankara, Turkey, 3Ankara Numune Hospital,Clinics of
Surgery, Ankara, Turkey, 4Ankara Numune Hospital,Clinics of Pathology, Ankara, Turkey.
P.B.14.10
Hepatocyte growth factor activates stromal fibroblasts to promote tumorigenesis in gastric cancer
P.B.14.11
Molecular characterization of lung cancer-infiltrating immunofibroblasts
X. Chen;
Shanghai Institute of Digestive of Surgery, Ruijin HospitalSurgery, Department, shanghai, China.
H. Cheng1, M. Bösch1, M. Novkovic1, L. Onder1, E. Scandella1, I. Tarantino2, A. Franzini3, R. Rodriguez4, M. Brutsche3, B. Ludewig1;
1
Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland, 2Department of Surgery, University of Heidelberg, Heidelberg, Germany, 3Department of Pneumology, Kantonsspital St.
Gallen, St. Gallen, Switzerland, 4Department of Pathology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
29
Monday
P.B.14.12
Autologous bone marrow Th cells can support multiple myeloma cell proliferation in vitro and in vivo
P.B.14.13
Development of a human organotypic tumor invasion model using Precision-Cut Lung Slices (PCLS) and cancer cell line MDA-MB-231
P.B.14.14
The role of SH3PXD2B/HOFI in the regulation of the tumor microenvironment
P.B.14.15
Epigenetic silencing of microRNA mediates prostaglandin E2/IL-6 signaling in the tumor-immune microenvironment
P.B.14.16
Functional heterogeneity in the epithelial component of human prostate cancers: epigenetic surprises after fluorescent cell sorting of primary cell cultures and
disaggregated tumour biopsies
D. Wang1, Y. Fløisand2, A. Tveita1, S. Bürgler1,3, A. Parente-Ribes1, P. Hofgaard1, P. Szodoray1, B. Nakken1, B. Bogen1, G. Tjønnfjord2, J. Dalgaard4, L. Munthe1;
1
Centre for Immune Regulation, Dept. of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, 2Dept of Hematology, Oslo University Hospital/National Hospital (Rikshospitalet),
Oslo, Norway, 3Swiss Experimental Infectious Diseases and Cancer Research, University Children’s Hospital, Zürich, Swaziland, 4Dept. of Hematology, Vestre Viken Hospital of Buskerud, Drammen, Norway.
S. Konzok1, S. Schindler1, D. Jonigk2, P. Braubach2, A. Braun1, K. Sewald1;
1
Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, 2Medical School Hannover, Hannover, Germany.
G. Adrienn1, E. Boldizsár1, Á. Veres1, A. Pap2, S. Török3, B. Döme3, L. Nagy2, Á. Lányi1;
1
Department of Immunology, University of Debrecen, Debrecen, Hungary, 2Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary, 3Department of Tumor Biology,
National Koranyi Institute of TB and Pulmonology, Budapest, Hungary.
P. Li;
Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Department of, Shanghai, China.
N. J. Maitland1, J. K. Rane1, F. M. Frame1, D. Pellacani1, H. Walker1, A. T. Collins1, V. M. Mann2, M. S. Simms2;
1
Univ of York, York, United Kingdom, 2Castle Hill Hospital, Hull, United Kingdom.
P.B.14.17
PD-1 pathway and HPV status in head and neck squamous cell cancer
P.B.14.18
Reinforcing effect of HMGB1 on hypoxia role in tumorigenesis
P.B.14.19
Sensitivity of leukemic T-cell lines to arsenic trioxide cytotoxicity is dependent on the induction of phosphatase B220/CD45R expression at the cell surface
P.B.14.20
CCR7 expression inversely correlates with VLA4 expression in CLL: prognostic implications
P.B.14.21
Adenosine deaminase and iNOsynthase: a potential tumor and angiogenesis markers in gallbladder cancer in Algerian patients
P.B.14.22
Correlation between molecular subtypes and prognosis of invasive breast cancer in young women in Tunisia
P. Baruah1, J. Bullenkamp1, M. Lee2, P. Wilson3, I. Dumitriu1;
1
St Georges University of London, London, United Kingdom, 2St Georges Hospital NHS Trust, London, United Kingdom, 3St Georges Hospital London NHS Trust, London, United Kingdom.
L. Maruscakova1, M. Bucova1, Z. Poljak2, I. Hulin2;
1
Institute of Immunology, Faculty of Medicine, Comenius University, Bratislava, Slovakia, 2Institute of Pathological Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
A. Mellouk1, M. Benbijja2, P. Bobé1;
1
Université Paris Sud and INSERM U1174, Orsay, France, 2Université Paris Sud and INSERM U1012, Le Kremlin Bicêtre, France.
B. Somovilla-Crespo, C. Cuesta-Mateos, M. Alfonso-Pérez, A. Redruello, A. Ramírez-Menjíbar, V. López-Huete, A. Kreutzmann, C. Muñoz-Calleja;
Hospital Universitario de La Princesa, Madrid, Spain.
N. Tounsi1, C. Bouzid2, K. Bentabak2, B. Djerdjouri1;
1
University of sciences and technology Houari Boumedienne, Algiers, Algeria, 2Centre Pierre et Marie Curie, Hôpital Mustapha Bacha, Algiers, Algeria.
H. Ayadi1, E. Ayadi1, B. Cherif1, R. Jlidi2;
1
Center of Biotechnology of Sfax, Sfax, Tunisia, 2Patholab, Sfax, Tunisia.
P.C.01 Granulocytes
Chairpersons: Sheena Cruickshank; Manchester, United Kingdom / Nicola Tamassia; Verona, Italy
30
P.C.01.03
The balance between activation and parasite modulation of dog neutrophils is crucial for Leishmania infantum infection
P.C.01.04
Eosinophils regulator vascular function and contribute to hypertension
P.C.01.05
The role of flow cytometry in Screening Chronic Granulomatous Disease
P.C.01.06
A complex network of trans diaphyseal blood vessels: Highway for bone marrow-derived cells?
P.C.01.07
A clinical and laboratory approach to the evaluation of innate immunity in pediatric cvid patients
P.C.01.08
Myeloid Tristetraprolin deteriorates host defense upon invasive infection by compromising neutrophil function
P.C.01.09
Neutrophils as suppressors of T lymphocyte proliferation
P.C.01.10
Cross-talk between human mesenchymal stem cells from periapical lesions and neutrophil granulocytes: role of IL-6
P.C.01.11
Induced stem (iPS) cell production from dermal fibroblast of AR-CGD patient with p67-phox defect
P.C.01.12
Pathogenesis and oxidase residual activity relation in chronic granulomatous disease
P.C.01.14
CD14-dependent premature cell death of human neutrophils induced by Brucella abortus lipopolysaccharide lipid A
P.C.01.15
Role of neutrophils in cancer-related inflammation: a genetic approach
M. Pereira1, A. Valério-Bolas1, D. Santos-Mateus1, A. Rodrigues1, M. Santos2, H. Rocha3, A. Santos3, M. Câmara4, C. Martins5, G. Alexandre-Pires2, I. Pereira da Fonseca2, G. Santos-Gomes1;
1
Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal, 2Centro Interdisciplinar de Investigação em Sanidade Animal, Faculdade de
Medicina Veterinária, Universidade de Lisboa, Lisbon, Portugal, 3Divisão de Medicina Veterinária, Guarda Nacional Republicana, Lisbon, Portugal, 4Évora City Council, Municipal Veterinary Office, Évora,
Portugal, 5CEDOC, Chronic Diseases Research Center, Immunology, NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal.
S. Withers1, R. Forman1, S. Meza-Perez2, D. Sorobetea3, K. Sitnik4, W. Agace5, K. Else1, A. Heagerty1, M. Svensson-Frej2, S. Cruickshank1;
1
University of Manchester, Manchester, United Kingdom, 2University of Lund, Lund, Sweden, 3University of Lund, Lund, Sweden, 4Danish Technical University, Copenhagen, Denmark, 5Danish Technical
University, Copenhagan, Denmark.
M. Y. Koker;
Department of Immunology, Medical School of University of Erciyes, Kayseri, Turkey.
A. Klingberg1, R. Danuser2, J. Stein2, M. Rhode3, M. Jäger1, A. Hasenberg1, M. Gunzer1;
1
University Hospital Essen, Essen, Germany, 2University Bern, Bern, Switzerland, 3Helmholtz Center for Infection Research, Braunschweig, Germany.
N. Kutukculer, E. Azarsiz, N. E. Karaca, E. Ulusoy, G. Koturoglu, G. Aksu;
Ege University Medical School, Izmir, Turkey.
F. Ebner1, V. Sedlyarov1, F. Kratochvill1, N. Gratz1, L. Kenner2, A. Villunger3, P. Kovarik1;
1
University of Vienna, Max F. Perutz Laboratories, Vienna, Austria, 2Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria, 3Medical University Innsbruck, Division of Developmental
Immunology, Innsbruck, Austria.
I. H. Hiemstra1, C. E. Aarts1, F. Pourfarzad1, T. K. van den Berg1, T. W. Kuijpers1,2;
1
Department of Blood Cell Research, Sanquin Research and Landsteiner laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Emma Children’s Hospital, Academic
Medical Center, University of Amsterdam, Amsterdam, Netherlands.
M. Marković1, S. Tomić2, D. Mihajlović2, Z. Dolčanin3, J. Djokić2, M. Čolić1,2;
1
Faculty of Medicine, University of Ni, Ni, Serbia, 2Medical Faculty of the Military Medical Academy, Belgrade, Serbia, 3State University of Novi Pazar, Novi Pazar, Serbia.
H. Avcılar, B. Saraymen, M. Y. Koker;
Department of immunology, University of Erciyes, Kayseri, Turkey.
M. Y. Koker, B. Saraymen, M. Kılıçer, H. Avcılar;
University of Erciyes, Department of Immunology of Medical Faculty, Kayseri, Turkey.
E. Barquero-Calvo1, R. A. Mora2, J. L. de Diego3, J. Gorvel4, E. Moreno2,1;
1
Universidad Nacional, Heredia, Costa Rica, 2Universidad de Costa Rica, San José, Costa Rica, 3Max Planck Institute for Infection Biology, Berlin, Germany, 4Centre d’Immunologie de Marseille-Luminy
(CIML), Marseille, France.
A. Ponzetta, M. Galdiero, M. Barbagallo, S. Gentile, M. Molgora, E. Bonavita, C. Garlanda, A. Mantovani, S. Jaillon;
Humanitas Clinical and Research Center, Rozzano (Milan), Italy.
P.C.01.17
The neutrophils and cytokines in athletes with different profiles of functional brain asymmetry
A. Tambovtseva1,2, I. Shvydchenko1, E. Berdichevskaya1, A. Stepukova1, J. Kujilnaya1;
Department of Physiology, Kuban State University of Physical Education, Sport and Tourism, Krasnodar, Russian Federation, 2Territorial Clinical Hospital #2, Krasnodar, Russian Federation.
1
P.C.01.18
Cytokine production by neutrophils in athletes with different profiles of functional brain asymmetry
P.C.01.19
Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils
P.C.01.21
Tpl2 is required for neutrophil antimicrobial functions
P.C.01.22
Activation of TAK1 by chemotactic factors and GM-CSF, and its impact on human neutrophil signaling and functional responses
P.C.01.23
Identification of Factors that Recruit Tumour-Associated Neutrophils to Head and Neck Squamous Cell Cancers
P.C.01.24
Gentamicine decreases and cefotaxime does not affects release of neutrophil extracellular traps (NETs). A preliminary results
P.C.01.25
CD80 and CD86 colocalized in NETs
N. Tamassia, M. Zimmermann, F. Bianchetto, F. Arruda-Silva, M. A. Cassatella;
University of Verona, Dep. of Pathology and Diagnostic, Verona, Italy.
N. V. Acuff, J. Elmore, T. Kuriakose, B. Rada, W. T. Watford;
University of Georgia, Athens, GA, United States.
P. P. McDonald1, S. Sylvain-Prévost1, T. Ear1, N. Flamand2;
1
Université de Sherbrooke, Sherbrooke, QC, Canada, 2Université Laval, Québec, QC, Canada.
Monday
I. Shvydchenko, E. Berdichevskaya, A. Tambovtseva, A. Stepukova, J. Kujilnaya;
Department of Physiology, Kuban State University of Physical Education, Sport and Tourism, Krasnodar, Russian Federation.
H. Niaz, K. Hunter, C. Murdoch;
The University of Sheffield, Sheffield, United Kingdom.
O. Ciepiela1, A. Manda-Handzlik2, S. Sieczkowska3, W. Bystrzycka3, A. Moskalik3;
1
Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age,Medical University of Warsaw, Warsaw, Poland, 2Medical University of Warsaw, Postgraduate School of Molecular
Medicine, Warsaw, Poland, 3Medical University of Warsaw, Students Scientific Group, Warsaw, Poland.
F. M. Rodriguez, I. T. Novak;
National University of Cordoba, Faculty of Medicine, Institute of Cell Biology, Cordoba, Argentina.
Chairpersons: Roland Jacobs; Hannover, Germany / Carsten Watzl; Dortmund, Germany
P.C.02.01
Antibody-mediated response of NKG2Cbright NK cells against human cytomegalovirus
P.C.02.02
Aryl-hydrocarbon receptor-dependent regulation of NK cell phenotype and function
P.C.02.03
Natural Killer cell dysfunction in Acute Myeloid Leukemia patients: in vitro recovery of NK cell function
P.C.02.04
Natural Killer cells targeting of human and mouse Cancer Initiating Cells
P.C.02.05
Longitudinal changes in natural killer cell receptors in moderate versus severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients
P.C.02.06
Viral downregulation of CD155 reveals strong effect of DNAM-1 in virus control by NK cells and macrophages
P.C.02.07
Frog skin derived antimicrobial peptide frenatin 2.1S enhances proinflammatory phenotype and activity of NK/NKT cells
P.C.02.08
The possible role of Galectin-9/TIM-3 pathway in fetomaternal tolerance in pregnant mice
P.C.02.09
Blockade of self-inhibitory KIR2DL receptors increases the capacity of NK cells to inhibit HIV-1 replication in vitro
M. Costa García1, A. Vera1, M. Moraru2, C. Vilches2, M. López-Botet1,3, A. Muntasell3;
1
Universitat Pompeu Fabra, Barcelona, Spain, 2Instituto de Investigación Sanitaria Puerta de Hierro, Majadahonda, Spain, 3Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain.
A. Stojanovic1, M. P. Correia1, C. Redaelli1,2, M. Platten1,2, A. Cerwenka1;
1
German Cancer Research Center (DKFZ), Heidelberg, Germany, 2University Hospital, Heidelberg, Germany.
B. Sanchez-Correa1, J. M. Bergua2, I. Casas2, M. J. Arcos2, H. Bañas2, C. Campos3, A. Pera3, S. Morgado1, J. J. Gordillo1, J. G. Casado4, E. Durán1, R. Solana3, R. Tarazona1;
1
University of Extremadura, Caceres, Spain, 2Hospital San Pedro de Alcantara, Caceres, Spain, 3IMIBIC-Hospital Reina Sofia - University of Cordoba, Cordoba, Spain, 4Minimally Invasive Surgery Centre.
University of Extremadura., Caceres, Spain.
C. Garofalo1, R. Tallerico1, L. Conti2, S. Lanzardo2, R. Sottile1, M. Todaro3, G. Stassi3, G. Parmiani4, F. Dieli5, F. Cavallo2, E. Carbone1;
1
department of experimental and clinical medicine, catanzaro, Italy, 2Department of Molecular Biotechnologies and Health Science University of Study of Tourin, Italy, Torino, Italy, 3Department of Surgical
and Oncological Sciences, University of Palermo, Palermo, Italy, Palermo, Italy, 4Unit of Immuno-Biotherapy of Melanoma and Solid Tumors, Division of Molecular Oncology, San Raffaele Foundation
Scientific Institute, Milan, Italy, Milano, Italy, 5Department of Biopathology, University of Palermo, Palermo, Italy, Palermo, Italy.
S. L. Hardcastle, E. W. Brenu, S. Johnston, T. Nguyen, T. K. Huth, S. Ramos, D. Staines, S. Marshall-Gradisnik;
Griffith University, Gold Coast, Australia.
S. Jonjic1, T. Lenac Rovis1, P. Kucan1, I. Brizic1, N. Stanietsky2, V. Juranic Lisnic1, S. Jordan3, A. Tomic1, M. Babic Cac1, P. Tsukerman2, M. Messerle4, O. Mandelboim2, A. Krmpotic1;
1
Faculty of Medicine University of Rijeka, Rijeka, Croatia, 2The Hebrew University, Jerusalem, Israel, 34Max von Pettenkofer-Institute, Ludwig-Maximilians-University, Munich, Germany, 4Hannover Medical
School, Hannover, Germany.
J. Pantic1, G. Radosavljevic1, I. Jovanovic1, J. Golubovic1, N. Arsenijevic1, J. Conlon2, M. L. Lukic1;
1
Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, Kragujevac, Serbia, 2SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster,
Coleraine, United Kingdom.
A. Lajkó1, M. Meggyes1,2, A. Totsimon1, J. Szántó1, É. Mikó1,2, L. Szereday1,2;
1
University of Pécs Clinical Center Department of Medical Microbiology and Immunology, Pécs, Hungary, 2Janos Szentagothai Research Centre, Pécs, Hungary.
C. Körner1, C. Simoneau1, M. Granoff1, B. Corleis1, E. Scully1, D. Kwon1,2, S. Jost1, M. Altfeld1,3;
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, United States, 2Massachusetts General Hospital, Boston, MA, United States, 3Heinrich Pette Institute, Hamburg, Germany.
1
P.C.02.10
Hyperglycemia promotes immunosuppressive environment and attenuate NK cells activity to tumour
P.C.02.11
Is there an immune contribution to the pathogenesis of idiopathic pulmonary artery hypertension?
I. Jovanovic, N. Gajovic, G. Radosavljevic, J. Pantic, N. Arsenijevic, M. Lukic;
Center for molecular medicine and stem cell research, Kragujevac, Serbia.
I. Tahrali1, U. C. Kucuksezer1, L. Pur-Ozyigit1, G. Okumus2, E. Kiyan2, G. Deniz1;
Istanbul University, Institute of Experimental Medicine, Dept. of Immunology, Istanbul, Turkey, 2Istanbul University, Istanbul Faculty of Medicine, Dept. of Pulmonology, Istanbul, Turkey.
1
P.C.02.12
Immune senescence is associated with increase in NK cell numbers/frequencies after ART in HIV-1 infected patients
P.C.02.13
Intracellular retention of ‘activation induced C-type lectin (AICL)’ the genetically linked ligand of the human activating NK receptor NKp80 is dependent on AICL
glycosylation
F. Ahmad, R. Jacobs, R. E. Schmidt;
S. Neuss, Y. Bartel, B. Bauer, A. Steinle;
Institute for Molecular Medicine, Frankfurt am Main, Germany.
P.C.02.14
Intravenous Immunoglobulin (IVIG) down-regulates cytolytic activity and induces apoptotic cell death of human natural killer cells
P.C.02.15
KIR repertoire in a healthy caucasian population. Comparison with latent infection and pulmonary tuberculosis patients from northern Spain
P.C.02.16
IFN-γ and TNF-α secretion by human NK cells activated by Leishmania major lipophosphoglycan 3 (LPG3)
P. Ponnuswamy, S. Bunk, A. Trbic, M. Malisauskas, H. Anderle, H. Butterweck, J. Ilas, A. Weber, W. Teschner, H. P. Schwarz, F. Scheiflinger, C. Hermann, B. M. Reipert;
Baxalta Innovations GmbH, Vienna, Austria.
E. Asensio-Montañés, F. Ausín, J. L. Arroyo, R. Agüero, M. C. Fariñas, J. G. Ocejo-Vinyals;
Hospital Universitario Marqués de Valdecilla, Santander, Spain.
S. Rasolzadeh1, M. Haji-Fatahaliha1, M. Hosseini1, M. Ghafari-Khamene2, A. Movassagh pour1, J. Majidi1, M. Yousefi1;
Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of, 2Islamic Azad University, Urmia, Iran, Islamic Republic of.
1
31
Monday
P.C.02.17
Lenalidomide induces immunomodulation in chronic lymphocytic leukemia and enhances antitumor immune responses mediated by NK and CD4 T cells
P.C.02.18
Marker negative cells residing in the lymphocyte gate
P.C.02.19
The SUMOylation pathway regulates PVR surface expression in Multiple Myeloma cells
P.C.02.20
A pilot investigation of intracellular signalling molecules required for Natural Killer cell activity in Myalgic Ecephalomyelitis/Chronic Fatigue Syndrome patients
P.C.02.21
NK cell antibody-mediated response against Epstein-Barr virus: role of the NKG2Cbright NK cell subset.
P.C.02.22
Killer-cell Immunoglobuline-like receptors on Natural killer and CD8 T cells in melanoma patients
P.C.02.22
Natural killer cell response to lentiviral gene delivery provides novel perspectives on the development of gene therapy applications
S. Lorenzo-Herrero1,2, A. Acebes-Huerta1,2, L. Huergo-Zapico1,2, M. Villa-Alvarez1,2, A. Lopez-Soto1,2, A. Gonzalez-Rodriguez3, A. Payer3, S. Gonzalez1,2;
1
Department of Functional Biology, University of Oviedo, Oviedo, Spain, 2Instituto Universitario de Oncologia del Principado de Asturias (IUOPA), Oviedo, Spain, 3Department of Hematology, Hospital
Universitario Central de Asturias (HUCA), Oviedo, Spain.
K. de Jonge1, P. Baumgaertner1, D. Speiser1,2;
1
Ludwig Center for Cancer Research of the University of Lausanne (LICR@UNIL), Lausanne, Switzerland, 2Dept. of Oncology, University Hospital Center (CHUV), Lausanne, Switzerland.
M. Rosa1, B. Zitti1, L. Quatrini1, C. Fionda1, H. Stabile1, M. Cippitelli1, A. Gismondi1, A. Santoni1,2, R. Paolini1,2;
1
Sapienza University of Rome, Rome, Italy, 2Institute Pasteur-Fondazione Cenci Bolognetti, Rome, Italy.
T. K. Huth1,2, E. W. Brenu1,2, D. R. Staines1,2, S. M. Marshall-Gradisnik1,2;
1
National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Southport, Australia, 2School of Medical Science, Griffith University, Southport, Australia.
M. López-Montañés1, J. Sintes1, M. Costa-Garcia1, A. Muntasell2, M. López-Botet1,2;
1
Universitat Pompeu Fabra, Barcelona, Spain, 2Institut Hospital del Mar dÍnvestigacions Mèdiques, Barcelona, Spain.
H. Martinez-Banaclocha1, L. Gimeno1, M. Bernardo-Pisa1, J. Bolarin1, M. Muro1, R. Lopez-Hernandez1, B. Las Heras-Ferre1, M. Moya-Quiles1, A. Minguela1, A. Mrowiec1, I. Legaz2, J. Frias3, A. Garcia Alonso1,
M. Alvarez-Lopez1, J. Martinez-Escribano3, J. Campillo1;
1
Immunology Service-University Clinical Hospital Virgen de la Arrixaca-IMIB. Murcia, El Palmar, Spain, 2Department of Social and Health Sciences, Area of Legal and Forensic Medicine. University of Murcia,
El Palmar, Spain, 3Dermatology Service-University Clinical Hospital Virgen de la Arrixaca-IMIB. Murcia, El Palmar, Spain.
C. Sayitoglu1,2, A. D. Duru3,4, M. Chrobok3,4, C. Chiang4, A. Parlar1,2, G. H. Senturk1,2, B. Erman1, E. Alici3,4, T. Sutlu2;
Sabanci University, Istanbul, Turkey, 2Sabanci University Nanotechnology Research and Application Center, Istanbul, Turkey, 3Karolinska Institutet, Stockholm, Sweden, 4Vaccine and Gene Therapy Institute
of Florida, Port St. Lucie, FL, United States.
1
P.C.03 Innate Lymphocytes
Chairpersons: Chiara Romagnani; Berlin, Germany / Rudi W. Hendriks; Rotterdam, Netherlands
32
P.C.03.01
Activation of group 2 innate lymphocytes is T cell dependent in house dust mite-mediated allergic airway inflammation in mice
P.C.03.02
NKG2D promotes B1a cell development and enhances protection against bacterial infection
P.C.03.03
Primary and chronic HIV infection differently modulates mucosal Vδ1 and Vδ2 T-cells differentiation profile and effector functions
P.C.03.04
IL-33 regulates liver inflammation by expansion of group 2 innate lymphoid cells and amplifying regulatory T cells
P.C.03.05
Human cutaneous Vδ1+ T cells: immunosurveillance and local checkpoint control
P.C.03.06
Analysis of novel reporter mice for ILC fate-mapping in health and disease
P.C.03.07
Group 2 innate lymphoid cells express functional NKp30 receptor inducing type 2 cytokine production
P.C.03.08
NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures
P.C.03.09
B lymphocytes participate on innate immune response against intracellular bacterial pathogen Francisella tularensis
P.C.03.10
Emerging role of innate lymphocytes (ILCs) in immune dysregulation in murine model of leaky SCID/Omenn syndrome
P.C.03.11
Characterization and quantification of innate lymphoid cell subsets in human lung tissue
P.C.03.12
Group III innate lymphoid cells regulate T cell-independent antibody response and natural antibody production
P.C.03.13
Innate lymphoid cells: novel players in human anti-tumor immunity?
P.C.03.14
Redefining ILC populations in human tissues and implication in cancer
P.C.03.15
ICOS signaling regulates expansion of group 2 innate lymphoid cells under homeostatic and inflammatory conditions
P.C.03.16
Group 3 innate lymphoid cells in human decidua
B. Li1, M. De Bruijn1, M. Lukkes1, I. Tindemans1, I. Bergen1, M. Brem1, D. Beerens1, A. Kleinjan1, H. Fehling2, R. W. Hendriks1;
1
Erasmus MC Rotterdam, Rotterdam, Netherlands, 2University Clinics Ulm, Ulm, Germany.
M. Lenartić1, V. Jelenčić1, F. Wensveen1, M. Ožanić, V. Mrvčić, S. Jurković, M. Šantić, B. Polić;
1
Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia, 2Department of Microbiology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia, 3Department of
Oncology, University Hospital Rijeka, Rijeka, Croatia.
E. Cimini, C. Agrati, G. D’Offizi, C. Vlassi, R. Casetti, A. Sacchi, R. Lionetti, V. Bordoni, N. Tumino, P. Scognamiglio, F. Martini;
National Institute for Infectious Diseases, Rome, Italy.
K. Karimi, K. Neumann, J. Meiners, R. Voetlause, W. Dammermann, S. Lüth, C. Wegscheid, G. Tiegs;
University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
O. Nussbaumer1, R. Woolf1, A. Hayday1,2;
1
King’s College London, London, United Kingdom, 2The Francis Crick Institute, Lincolns Inn Fields Laboratories, London, United Kingdom.
M. Kindermann, T. Mchedlidze, M. Neurath, S. Wirtz;
Medical Department 1, Erlangen, Germany.
M. Salimi1, L. Xue1, H. Jolin2, C. Hardman2, D. J. Cousins3, A. N. McKenzie2, G. S. Ogg1;
1
Oxford University, Oxford, United Kingdom, 2MRC Laboratory of Molecular Biology, Cambridge, United Kingdom, 3Department of Infection, Immunity and Inflammation, NIHR Leicester Respiratory
Biomedical Research Unit, Leicester, United Kingdom.
P. Carrega1, F. Loiacono1, E. Di Carlo2,3, A. Scaramuccia4, R. Conte4, B. Morandi5, M. C. Mingari4,5, L. Moretta1, G. Ferlazzo6,7;
1
Giannina Gaslini Institute, Genoa, Italy, 2Department of Medicine and Sciences of Aging, “G. d’Annunzio” University, Chieti, Italy, 3Centro di Scienze dell’Invecchiamento, Fondazione Universita` “G.
d’Annunzio”, Chieti, Italy, 4IRCCS-Azienda Ospedaliera Universitaria San Martino/IST-Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy, 5Department of Experimental Medicine, University of
Genova, Genoa, Italy, 6Laboratory of Immunology and Biotherapy, Department of Human Pathology, University of Messina, Messina, Italy, 7Cell Therapy Program, Azienda Ospedaliera Universitaria
Policlinico “Gaetano Martino”, Messina, Italy.
Z. Krocova;
FMHS UO, Hradec Kralove, Czech Republic.
K. Csomos1, S. Yu2, B. Ujhazi1, B. Causton1, C. Dahlberg3, L. Westerberg3, B. Medoff1, M. Colonna4, L. D. Notarangelo5, J. E. Walter1,6,5;
1
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2Department of Medical Oncology, Dana-Farber Cancer
Institute and Harvard Medical School, Boston, MA, United States, 3Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden, 4Department of Microbiology, Tumor
and Cell Biology, Karolinska Institute, St. Louis, MO, United States, 5Division of Immunology, Children’s Hospital Boston, Harvard Medical School, Boston, MA, United States, 6Division of Pediatric Allergy/
Immunology, Massachusetts General Hospital for Children, Boston, MA, United States.
S. Provoost, K. C. De Grove, F. M. Verhamme, K. R. Bracke, G. F. Joos, T. Maes, G. Brusselle;
Ghent University Hospital, Ghent, Belgium.
M. Miyajima1, G. Magri2, A. Mortha3, M. Merad3,4, A. Cerutti2,4,5, S. Fagarasan1;
1
Laboratory for Mucosal Immunity, RIKEN Center for Integrative Medical Sciences, RIKEN Yokohama,, Yokohama, Japan, 2Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain, 3Tisch
Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, NY, United States, 4Immunology Institute, Department of Medicine, Icahn School of Medicine at
Mount Sinai, New York, New York, NY, United States, 5Department of Pathology, Hospital del Mar, Universitat Autònoma de Barcelona and Universitat Pompeu Fabra, Barcelona, Spain.
B. Salomé1, S. Trabanelli1, K. Michaud2, P. Mangin2, M. Chevalier3, S. Abed Maillard4, L. Cagnon4, J. Rivals5, D. E. Speiser1,4, L. Derré3, P. Mathevet6, L. Kandalaft4, G. Coukos1,4, P. Romero1, C. Jandus1;
1
Ludwig Center of the University of Lausanne, Lausanne, Switzerland, 2Centre Universitaire Romand de Médecine Légale (CURML), University Hospital (CHUV), Lausanne, Switzerland, 3Department of
Urology, University Hospital (CHUV), Lausanne, Switzerland, 4Department of Oncology, University Hospital (CHUV), Lausanne, Switzerland, 5Department of Otolaryngology and Head and Neck Surgery,
University Hospital (CHUV), Lausanne, Switzerland, 6Department of Gynecology, University Hospital (CHUV), Lausanne, Switzerland.
Y. Simoni;
A*STAR SIgN, Singapore, Singapore.
D. Paclik, C. Stehle, A. Hutloff, C. Romagnani;
Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
E. Montaldo1, P. Vacca2, D. Croxatto2, F. Loiacono1, L. Moretta1, M. C. Mingari2,3;
1
Istituto Giannina Gaslini, Genova, Italy, 2Dipartimento di Medicina Sperimentale, Università degli studi di Genova, Genova, Italy, 3IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genova, Italy.
P.C.03.17
Homing of human peripheral blood innate lymphoid cells in homeostasis
P.C.03.18
Innate lymphoid cells type-2 contribute to macrophage polarization and reduce defenses against pneumococci.
Y. E. Bar-Ephraim, V. Mourits, K. Lakeman, R. E. Mebius;
VU University Medical Center, Amsterdam, Netherlands.
S. Saluzzo1,2,3, A. D. Gorki1,2, O. Sharif1,2, J. Warszwaska1,2, R. Martins1,2, K. Lakovits1,2, A. Hladik1,2, I. Mesteri1, A. McKenzie3, S. Knapp1,2;
Medical University of Vienna, Vienna, Austria, 2CeMM - Center of Molecular Medicine of the Austrian Accademy of Science, Vienna, Austria, 3MRC Laboratory of Molecular Biology, Cambridge, United
Kingdom.
P.C.03.19
Identification of a novel T cell subset in the murine submandibular glands
P.C.03.20
Phenotypic characterization of innate lymphoid cells in the peripheral blood of septic patients
T. K. Erick, L. Brossay;
Brown University, Providence, RI, United States.
A. Niembro Guerrero1, L. Arriaga Pizano2, E. Ferat Osorio2, L. Serrano2, O. Hernández Martinez2,3, S. Estrada Parra1, R. Chacón Salinas1, I. Estrada García1, I. Wong Baeza1;
1
Escuela Nacional de Ciencias Biológicas, México, D.F., Mexico, 2Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, México, D.F., Mexico, 3Secretaría de Salud. Mexico, Mexico City, Mexico.
Monday
1
P.C.04 Immune Suppression
Chairpersons: Dicle Guc; Ankara, Turkey / Alessandra Sacchi; Rome, Italy
P.C.04.01
Innate immune monitoring of invasive fungal infections in severe burn injury
P.C.04.02
Granulocytic subset of myeloid derived suppressor cells in rats with mammary carcinoma
P.C.04.03
In HIV+ patients, Myeloid Derived Suppressor Cells induce T cell anergy by suppressing CD3zeta expression through ELF-1 inhibition
P.C.04.04
Differential induction of Ly6G and C positive MDSC in liver versus kidney fibrosis
P.C.04.05
GM-CSF and Glucocorticoids synergistically enhance retinoic acid production in monocytes
P.C.04.06
Induction of myeloid-derived suppressor cells in cryopyrin-associated periodic syndromes
P.C.04.07
Modulation of CD11b+Gr-1+ MDSCs function by IgG and IgM
P.C.04.08
DNA methylation governs the ability of apoptotic cells to differentially modulate the immune response
P.C.04.09
Commensal bacteria and tonic type-I interferons drive spontaneous maturation of dendritic cells in the immunological steady state
P.C.04.11
Immunological tolerance to inducible neo-antigens is mediated by steady state Langerhans cells
P.C.04.12
HIV infection of monocytes-derived dendritic cells inhibits Vgamma9Vdelta2 T cells functions
P.C.04.13
Commensal bacteria-derived membrane vesicles as novel immunomodulatory therapeutic agents
P.C.04.14
Hepatocyte dependent induction of regulatory T-cell subsets
P.C.04.15
Defining the Role of Myeloid-Derived Suppressor Cells (MDSC) in Myelodysplastic Syndromes (MDS)
P.C.04.16
The role of properdin in tumour development and cell recruitment
D. Jorge Cordeiro1, M. Legrand2, Q. Ressaire2, L. Homyrda3, A. Alanio4, M. Chaussard2, B. Denis2, M. Chaouat2, A. Mebazaa2, A. Toubert1, A. Haziot1, H. Moins-Teisserenc1;
1
INSERM 1160 Hopital Saint Louis, Paris, France, 2Burn Unit Hopital Saint Louis, Paris, France, 3Laboratoire d’Immunologie Hopital Saint Louis, Paris, France, 4Laboratoire de Myco-Parasitologie Hopital
Saint Louis, Paris, France.
Y. Dolen, G. Gunaydin, G. Esendagli, D. Guc;
Hacettepe University, Cancer Institute, Ankara, Turkey.
N. Tumino, F. Turchi, S. Meschi, E. Lalle, V. Bordoni, R. Casetti, C. Agrati, E. Cimini, F. Martini, A. Sacchi;
I. Ludwig-Portugall1, B. Höchst2, C. Kurts1, P. Knolle2, L. Dieh3;
1
Institute of experimental immunology, Bonn, Germany, 2Institute of molecular immunology, Munich, Germany, 3Institute of experimental immunology and hepatology, Hamburg-Eppendorf, Germany.
A. Brockhausen1, T. Weinhage2, J. Däbritz2,3, J. Ehrchen4,3, D. Föll2, J. Roth5, C. Sunderkötter1,4, G. Varga2;
1
Department of translational Dermatoinfectiology, Münster, Germany, 2Pediatric Rheumatology and Immunology, Münster, Germany, 3Interdisciplinary Centre of Clinical Research, Münster, Germany,
4
Department of Dermatology, Münster, Germany, 5Institute of Immunology, Münster, Germany.
M. Ballbach, T. Hall, A. Brand, D. Neri, A. Singh, I. Schaefer, S. Hansmann, R. Handgretinger, J. Kuemmerle-Deschner, D. Hartl, N. Rieber;
University of Tuebingen, Tuebingen, Germany.
C. Kyvelidou, D. Sotiriou, I. Athanassakis;
Department of Biology, University of Crete, Heraklion, Greece.
C. A. Notley, C. K. Jordan, J. L. McGovern, M. A. Brown, M. R. Ehrenstein;
University College London, Division of Medicine, London, United Kingdom.
S. Muth1, T. Hain1, S. Lienenklaus2, T. Schwanz3, S. Weiss2, U. Kalinke4, H. Schild1, H. C. Probst1;
1
Institute for Immunology, University Medical Center, Mainz, Germany, 2Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany, 3Department of Medical Microbiology
and Hygiene, University Medical Center, Mainz, Germany, 4Institute for Experimental Infection Research, TWINCORE, Hannover, Germany.
H. Strandt1, R. Mittermair1, V. Hoepflinger1, P. Hammerl1, D. Kaplan2, D. Wirth3, A. Stoecklinger1;
1
Department of Molecular Biology, University of Salzburg, Salzburg, Austria, 2Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN, United States, 3HelmholtzZentrum für Infektionsforschung, Braunschweig, Germany.
A. Sacchi, A. Rinaldi, N. Tumino, R. Casetti, C. Agrati, F. Turchi, V. Bordoni, E. Cimini, F. Martini;
E. Alpdundar1, M. Aydin2, S. Yildiz1, C. Akcali3, I. Gursel2, M. Gursel1;
1
Middle East Technical University, Ankara, Turkey, 2Bilkent Üniversity, Ankara, Turkey, 3Ankara University, Ankara, Turkey.
M. Pfaff, K. Karimi, L. Diehl, G. Tiegs;
Institute of Experimental Immunology & Hepatology, 20246, Germany.
S. Wei1, J. Liu1, E. A. Eksioglu1, X. Chen1, D. Gabrilovich2, P. Epling-Burnette,1, A. List1;
1
Moffitt Cancer Center, Tampa, FL, United States, 2The Wistar Institute,, Philadelphia, PA, United States.
I. A. Alrayahi1, M. Browning1, L. Machado2, C. Stover1;
1
University of Leicester, Leicester, United Kingdom, 2University of Northampton, Northhampton, United Kingdom.
Chairpersons: Éva Rajnavölgyi; Debrecen, Hungary / Jose A. Villadangos; Melbourne, Australia (tbc)
P.C.05.01
Leukocyte Immunoglobulin-like Receptors expression on SLAN-Dendritic Cells
P.C.05.02
Prostaglandin E2 can rescue indoleamine-2,3-dioxygenase expression in aryl hydrocarbon receptor negative dendritic cells
P.C.05.03
Mechanisms of induction of paralyzed dendritic cells with poor antigen presentation function following Systemic Inflammatory Response Syndrome (SIRS)
P.C.05.04
Effects of fractions from exopolysaccharides and dried biomass from Cyanobacterium aponinum from the Blue Lagoon in Iceland on stimulation of human
monocyte-derived dendritic cells
D. Ordóñez del Valle, D. Tufa, K. Kniesch, R. E. Schmidt, T. Witte;
I. Bargen1, K. Zado1, S. Kadow1,2, C. Esser1;
1
IUF - Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany, 2Institute for Molecular Biology, University of Duisburg-Essen, Germany.
J. A. Villadangos;
The University of Melbourne, Melbourne, Australia.
A. B. Gudmundsdottir1,2, S. M. Pokharel1,2, H. Heimisson2, S. Omarsdottir2, A. Brynjolfsdottir3, E. S. Olafsdottir2, I. Hardardottir2, J. Freysdottir1,2;
1
Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland, 2University of Iceland, Reykjavik, Iceland, 3Blue Lagoon Ltd, Grindavik, Iceland.
33
Monday
P.C.05.05
Functional consequences of Glucocorticoid-Induced Leucine Zipper protein expression in dendritic cells
P.C.05.06
Developmental heterogeneity of splenic CD11b+ DCs
P.C.05.08
Identity and flexibility of common dendritic cell progenitor
P.C.05.09
A role of Annexin1 in human Langerhans dendritic cell differentiation
P.C.05.10
Tumor necrosis factor-α promotes survival and phenotypic maturation of poly(I:C)-treated dendritic cells but impairs their Th1 and Th17 polarizing capability
P.C.05.11
Dual role of CD1a in modulation of Dendritic Cell phenotype and function after contact with heated and/or irradiated lymphocytes
J. Calmette1, M. Ellouze2, M. Pallardy3,4, F. Bachelerie1,5, E. Morand6, V. Godot2,7, G. Schlecht-Louf1,8,5;
1
INSERM UMR996, Clamart, France, 2INSERM U955 - IMRB- Team 16 - Vaccine Research Institute, Créteil, France, 3INSERM UMR996, Chatenay Malabry, France, 4University Paris-Sud, Faculty of Pharmacy,
Chatenay Malabry, France, 5LabEx LERMIT, Chatenay Malabry, France, 6Southern Clinical School, Monash University Faculty of Medicine, Nursing & Health Sciences, Melbourne, Australia, 7University
Paris-Est Créteil, Faculty of Medicine, Créteil, France, 8University Paris-Sud, Faculty of Medicine, Le Kremlin Bicêtre, France.
B. Schraml1, J. van Blijswijk2, K. Snelgrove2, N. Rogers2, C. Reis e Sousa2;
1
Institute for Medical Microbiology, Immunology and Hygiene, Munich, Germany, 2Immunobiology Laboratory, The Francis Crick Institute, Lincoln’s Inn Fields Laboratories, London, United Kingdom.
T. Ohteki, N. Onai;
Tokyo Medical and Dental University, Tokyo, Japan.
R. Köffel1,2, T. Bauer3, I. Borek4, C. Tam-Amersdorfer4, F. DÀcquisto5, H. Weyd6, P. Krammer6, H. Strobl4, A. Ellinger2, A. Dräger1;
1
Institute of Anatomy, Dept. of Cell Biology, University of Bern, Bern, Switzerland, 2Center for Anatomy and Cell Biology, Dept. for Cell Biology and Ultrastructural Research, Medical University of Vienna,
Vienna, Austria, 3Institute of Cancer Research, Dept. of Medicine I, Medical University of Vienna, Vienna, Austria, 4Institute of Pathophysiology and Immunology, Medical University of Graz, Graz, Austria,
5
William Harvey Research Institute, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, United Kingdom, 6Tumor Immunology Program, German Cancer
Research Center, Heidelberg, Germany.
T. Džopalić1, A. Thorne2, S. Tomić2, B. Pavlović3, D. Mihajlović2, M. Čolić1,2;
1
Medical Faculty, University of Nis, Nis, Serbia, 2Medical Faculty of the Military Medical Academy, University of Defense, Belgrade, Serbia, 3Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
J. M. do Carmo1, C. M. Cavalcanti2, R. B. Baleeiro2, P. C. Bergami-Santos2, P. Walden3, J. M. Barbuto2;
Instituto Tocantinense Presidente Antônio Carlos, Porto Nacional, Brazil, 2Universidade de São Paulo, São Paulo, Brazil, 3Charité Universitatzmedizin, Berlin, Germany.
1
P.C.05.12
Exposure to microbial soluble factors affects the phagocytic ability of the in vitro generated dendritic cell and its subsequent influence on the activation of
autologous T cells
Y. Haileselassie1, M. Navis1, K. R. Qazi1, B. Rethi2, E. Sverremark-Ekström1;
1
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden, 2Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm,
Sweden.
P.C.05.13
The inhibitory effects of thymol and carvacrol on dendritic cell activation and function
P.C.05.15
mKLRL1, a novel C-type lectin-like inhibitory receptor, regulates the maturation of dendritic cells and plays important roles in immunity
P.C.05.16
Pig as a biomedical model: putting the porcine lung dendritic cells/macrophages network into light
P.C.05.17
How dendritic cells phenotype and migration differ in gut infection
P.C.05.18
Modulation of T-helper polarizing capability of human monocyte derived Langerhans cells by TLR-3 and Dectin-1 agonists
Z. Amirghofran, H. Ahmadi, M. Karimi, F. Kalantar;
Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of.
G. Liu, P. Li, X. Dai, Y. Yu;
Department of Immunology, Second Military Medical University, Shanghai, China.
P. Maisonnasse1, E. Bouguyon1, M. Bourge2, G. Piton3,4, A. Ezquerra5, C. Urien1, J. Leplat3,4, G. Simon6,7, C. Chevalier1, S. Vincent-Naulleau3,4, E. Crisci8, M. Montoya8,9, I. Schwartz-Cornil1, N. Bertho1;
1
Virologie et Immunologie Moléculaires, INRA, Jouy-en-Josas, France, 2I2BC, CNRS, Gif-sur-Yvette, France, 3UMR Génétique Animale et Biologie Intégrative , INRA, Jouy-en-Josas, France, 4Direction
des Sciences du Vivant, Institut de Radiobiologie Cellulaire et Moléculaire, Laboratoire de Radiobiologie et Etude du génome, CEA, Jouy-en-Josas, France, 5Dpto. de Biotecnología, INIA, Madrid, Spain,
6
Laboratoire de Ploufragan/Plouzané, Unité Virologie Immunologie Porcines, ANSES, Ploufragan, France, 7Université Européenne de Bretagne, Rennes, France, 8CReSA, UAB-IRTA, Bellaterra, Spain, 9IRTA,
Barcelona, Spain.
T. A. Altorki1, A. Brass2, W. Muller1, S. Cruickshank1;
1
The University Of Manchester, Faculty of Life Sciences, Manchester, United Kingdom, 2The University Of Manchester, School of Computer Science, Manchester, United Kingdom.
I. Rajkovic1, S. Vasilijic1,2, D. Vucevic1,2, A. Thorne2, M. Markovic3, M. Colic1,3;
1
Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade, Serbia, 2Institute for Medical Research, Military Medical Academy, Belgrade, Serbia, 3Faculty of Medicine, University
of Nis, Nis, Serbia.
Chairpersons: Thomas A. Kufer; Stuttgart, Germany / Mikka Rämet; Tampere, Finland
P.C.06.01
Expression and function in platelets of IL-1R8 (TIR8/SIGIRR), a regulatory member of the IL-1 receptor family
P.C.06.02
Identification of minimal oligodeoxynucleotide motifs that are distinctively recognized by human or murine TLR9
P.C.06.03
Impact of NOD1 on IL-10 signaling
P.C.06.04
Monarch-1, a member of NLR family, negatively regulates the innate immune signaling induced by viral infection
F. Riva1, A. Anselmo2, S. Gentile2, C. Soldani2, C. Mazzon2, N. Polentarutti2, P. Carullo2, M. Bacci2, A. Voza2, A. Mantovani2, C. Garlanda2;
1
university of milano, milano, Italy, 2Humanitas Clinical and Research Center, rozzano, Italy.
J. Pohar1, A. Kunik-Krajnik1, D. Lainček1, C. Yamamoto2, R. Fukui2, K. Miyake2, R. Jerala1,3, M. Benčina1,3;
1
National Institute of Chemistry, Ljubljana, Slovenia, 2The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, 3Centre of Excellence EN-FIST, Ljubljana, Slovenia.
T. Neuper, A. Duschl, J. Horejs-Hoeck;
Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
S. Chen1,2, J. P. Ting3;
1
Taipei Medical University, Taipei, Taiwan, 2National Yang-Ming University, Taipei, Taiwan, 3Unversity of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
P.C.06.06 KIR/HLA-C genomic profiles of women with fibromyalgia syndrome in the southeast of Spain
I. Legaz Pérez1,2, L. Gimeno3, G. Salgado4, E. Novoa4, J. Bolarin5, A. Mrowiec5, P. Martinez5, S. Soriano-Diaz5, A. Bernal-Ramos5, A. Bermudez-Torrente6, A. Martinez-Leon7, I. Ibernon-Caballero8, M. Muro5,
M. Moya-Quiles5, J. Campillo5, A. Minguela5, M. Alvarez-Lopez5, I. Lozano9, A. Garcia-Alonso5;
1
University of Murcia, Murcia, Spain, 2Immunology Service. Hospital Virgen de la Arrixaca, Murcia, Austria, 3Immunology Service, Hospital Virgen de la Arrixaca. Murcia, Spain, 4Immunology Service.
Hospital Virgen de la Arrixaca, Murcia, Spain, 5Immunology Service, Hospital Virgen de la Arrixaca, Murcia, Spain, 6Rheumatology Department. University Clinical Hospital Virgen de la Arrixaca, Murcia,
Spain, 7Medical Family Health, San Andrés-Murcia., Murcia, Spain, 8Psychiatry Department-University Hospital Virgen de la Arrixaca, Murcia, Spain, 9Psychiatry Department-Hospital Virgen de la Arrixaca,
Murcia, Spain.
P.C.06.07
Outer Membrane Vesicles from periodontal pathogens contain ligands that stimulate TLR and NLR receptors
J. D. Cecil, N. M. O’Brien-Simpson, J. Lenzo, J. Holden, Y. Chen, K. Gause, F. Caruso, E. Reynolds;
The University of Melbourne, Parkville, Australia.
P.C.06.08 Crosstalk in innate immunity: Microbial Stress Response and Toll-like receptors
J. Perego1, C. Bourbon-Caillet1, E. Gatti1,2, P. Pierre1,2;
1
CIML, Marseille, France, 2Institute for Research in Biomedicine - iBiMED and Aveiro Health Sciences Program, University of Aveiro, Aveiro, Portugal.
P.C.06.09 Expression and regulation of the immune modulatory enzyme Indoleamine 2, 3-dioxygenase (IDO) in human epithelial cells
W. A. S. Aldajani, F. Salazar, A. Knox, A. Ghaemmaghami;
34
P.C.06.10
Induction of antigen specific cytotoxic T cells in response to sterile injury is inhibited by Lipopolysaccharide
P.C.06.11
The E3-ubiquitin-ligase Cbl-b controls anti-fungal immune responses by regulating Dectin-1 signaling
P.C.06.12
NOD-like receptor expression in human MSCs
R. Chakraborty1, I. H. Frazer1, M. Kendall2;
1
Translational Research Institute, Brisbane, Australia, 2Australian Institute for Bioengineering and Nanotechnology, Brisbane, Australia.
G. Wirnsberger1, F. Zwolanek2, T. Asaoka1, I. Kozieradzki1, L. Tortola1, R. Wimmer1, F. Ikeda1, K. Kuchler1, K. Kuchler2, J. Penninger1;
1
IMBA, Vienna, Austria, 2MFPL, Vienna, Austria.
V. Durand-Onayli1, N. Ketterl2, A. Jetzinger1, A. Duschl1, D. Strunk2, J. Horejs-Hoeck1;
1
Department of Molecular Biology, University of Salzburg, Salzburg, Austria, 2Expt & Clin Cell Therapy Inst, Paracelsus Medical University, Salzburg, Austria.
P.C.06.14
Analysis of pattern recognition receptor (PRR) expression and regulation in Langerhans cells (LCs) in a three-dimensional model of barrier disrupted human skin
P.C.06.15
Modulation of myeloperoxidase activity by the long pentraxin 3 and the synergistic effects towards conidia from Aspergillus fumigatus
P.C.06.16
The role of innate immunity in the pathogenesis of pityriasis rosea
P.C.06.17
In vivo efficiency of nucleic acid based TLR agonists in Salmonella vaccine formulations
P.C.06.18
Dynamics of SSc5D expression and its role in pathogen recognition and inflammation
P.C.06.19
Effect of TLR-7 and -9 stimulation on B cells in Sjögren’s syndrome
P.C.06.20
Generation of a monocytic reporter cell line with high sensitivity towards selected toll-like receptor ligands
P. M. Tajpara1, T. Berger2, M. Mildner2, A. Elbe-Bürger1;
1
Laboratory of Cellular and Molecular Immunobiology of the Skin, Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria,
2
Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria.
M. Abo ElEla1, M. ElKomy1, R. Abdel Hay1, K. Amr2, A. Sharoubim1;
1
Cairo University, Cairo, Egypt, 2National Research Institute, Cairo, Egypt.
K. Almacioglu, F. Yagci, I. Gursel;
Thorlab, Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey.
Monday
K. Daigo, A. Inforzato, D. Morone, S. Valentino, F. Petroni, A. Mantovani, B. Bottazzi;
IRCCS Humanitas Research Hospital, Rozzano (Milan), Italy.
R. F. Santos1,2, S. Mendes1,2,3, C. Bessa-Pereira1,2,4, L. Oliveira1,2, A. M. Carmo1,2,4;
1
IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal, 2Cell Activation and Gene Expression Group, Instituto de Investigação e Inovação em Saúde, Porto, Portugal, 3UTAD - Universidade de Trásos-Montes e Alto Douro, Vila Real, Portugal, 4ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
M. Karlsen1, S. Appel1, J. G. Brun2,3, R. Jonsson1,2, T. Hansen3,4;
1
Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, 2Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, 3Department of
Clinical Science, University of Bergen, Bergen, Norway, 4Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway.
C. Battin1, A. Hennig1, S. Jutz1, F. Kellner2, J. Huppa2, P. Steinberger1, W. Paster1;
1
Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Vienna, Austria, 2Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and
Immunology, Vienna, Austria.
P.C.07 Cytosolic Sensing and Inflammasome
Chairpersons: Greta Guarda; Lausanne, Switzerland / Natasa Kopitar-Jerala; Ljubljana, Slovenia
P.C.07.01
Absent in melanoma 2 deficiency attenuates susceptibility to H1N1 influenza A virus-induced lung injury
P.C.07.02
Streptococcal NAD+-glycohydrolase regulates inflammasome activation
P.C.07.03
Overexpression of MAVS and STING and downregulation of NLRX1 in HIV patients assuming efficient antiretroviral therapy
P.C.07.04
Dynamin-related protein-1 modulates the NLRP3 inflammasome activation
P.C.07.05
Immunosuppressive effects of synthetic oligodeoxynucleotide A151 on inflammasome activation
P.C.07.06
Influence of the inflammasome components ASC and caspase-1 in Sporothrix schenckii infection
P.C.07.07
Blockage of caspase-1 activation ameliorates inflammasomes-mediated bone marrow inflammation in mice after hematopoietic stem cell transplantation
P.C.07.08
Human gestation-associated tissues utilise different caspases to process IL-1β following flagellin treatment
P.C.07.09
Identifying Novel Regulators of NLRC3-dependent Interferon Responses
P.C.07.10
Inflammasome regulates the IL-1β production in fetal membranes infected by group B Streptococcus
P.C.07.11
Group A streptococcus interactions with purinergic receptors
P.C.07.12
Pro-inflammatory casapase expression and inflammasome activation in stefin B -deficent and -trisomic mice
P.C.07.13
Spleen tyrosine kinase regulates TLRs and NLRP3 inflammasome activation in macrophages
P.C.07.14
TCR-dependent sensitization of human γδ T cells to non-myeloid IL-18 in cytomegalovirus and tumor stress surveillance
P.C.07.15
A new role for nucleotide-binding oligomerization domain 1 (NOD1) in human brain pericyte-mediated inflammation
P.C.07.16
Study on the role of alpha-defensin in NLRP3 inflammasome dependent IL-1beta secretion of mesenchymal stem/stromal cells
P.C.07.17
Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation
J. Wang, H. Zhang, T. Yang, K. Chen, J. Kolls;
University of Pittsburgh, Pittsburgh, PA, United States.
D. Hancz1, E. Westerlund1, C. Valfridsson1, J. F. Love2, M. O’Seaghdha2, M. R. Wessels2, J. J. Persson1;
1
Section for Immunology, Department of Experimental Medical Science, Lund University, Lund, Sweden, 2Division of Infectious Diseases, Boston Children’s Hospital and Department of Pediatrics, Harvard
Medical School, Boston, MA, United States.
M. Nasi1, M. Digaetano2, S. De Biasi1, E. Bianchini1, S. Pecorini1, R. Bartolomeo1, M. Pinti1, L. Gibellini1, V. Borghi2, C. Mussini1,2, A. Cossarizza1;
1
University of Modena and Reggio Emilia, Modena, Italy, 2Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy.
S. Park, J. Won, I. Hwang, S. Hong, J. Yu;
Department of Microbiology, Brain Korea 21 PLUS project for Medical Science, Yonsei University College of Medicine, Seoul, Korea, Republic of.
N. Sürücü1, E. Gül1, I. Gursel2, M. Gursel1;
1
Middle East Technical University, Ankara, Turkey, 2Bilkent Üniversity, Ankara, Turkey.
A. C. Gonçalves1, L. S. Ferreira1, M. R. Avelar1, F. A. Manente1, M. C. Polesi1, C. R. de Andrade2, D. S. Zamboni3, I. Z. Carlos1;
1
Department of Clinical Analysis, Faculty of Pharmaceutical Sciences of Araraquara, São Paulo State University (FCF/UNESP), Araraquara, Brazil, 2Department of Physiology and Pathology, Faculty of
Dentistry of Araraquara, São Paulo State University (FOAR/UNESP), Araraquara, Brazil, 3Department of Cell Biology, Ribeirão Preto Medical School, University of São Paulo (FMRP/USP), Ribeirão Preto,
Brazil.
L. Zeng;
The Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
A. H. Bryant, S. E. Owens, R. H. Jones, I. M. Sheldon, C. A. Thornton;
Institute of Life Science, College of Medicine, Swansea University, Swansea, United Kingdom.
B. K. Davis, A. M. Tocker, S. M. Talento;
Franklin and Marshall College, Lancaster, PA, United States.
M. González1, S. Giono1, S. Rodríguez1, A. Espejel2, M. Solís2, S. Nava2, V. Zaga2, G. Estrada2;
1
Escuela Nacional de Ciencias Biológicas, Mexico, Mexico, 2Instituto Nacional de Perinatología, Mexico, Mexico.
E. Westerlund, D. Hancz, C. Valfridsson, J. J. Persson;
Lund University, Lund, Sweden.
M. Trstenjak-Prebanda1, K. Maher1, V. Brault2, J. Završnik1, B. Turk1, Y. Hérault2, N. Kopitar-Jerala1;
1
Jozef Stefan Institute, Ljubljana, Slovenia, 2Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, Strasbourg, France.
W. Lin;
Pharmacology, National Taiwan University, Taipei, Taiwan.
F. Guerville1,2,3, S. Daburon1,3, R. Marlin1,3, L. Lartigue4, S. Loizon1,3, V. Pitard1,3, L. Couzi1,3,2, J. Moreau1,3, J. Déchanet-Merville1,3, B. Faustin1,3;
1
University Bordeaux, bordeaux, France, 2Nephrology and Renal transplantation department, Bordeaux University Hospital, Bordeaux, France, 3CNRS UMR 5164, Bordeaux, France, 4INSERM U916 VINCO,
Institut Bergonié, bordeaux, France.
R. Navarro1, P. Delgado-Wicke1, N. Nuñez-Prado1, M. Compte1, A. Blanco-Toribio1, G. Nuñez2, L. Alvarez-Vallina3, L. Sanz1;
1
Hospital Puerta de Hierro, Majadahonda, Spain, 2University of Michigan, Ann Arbor, MI, United States, 3Aarhus University, Aarhus, Denmark.
T. H. Chen1, K. Nakamura2, T. Ayabe2, B. L. Chiang1;
1
Graduate Institute of Immunology, National Taiwan University, Taipei City, Taiwan, 2Department of Cell Biological Science, Faculty of Advanced Life Science, Graduate School of Life Science, Hokkaido
University, Sapporo, Hokkaido, Japan.
G. A. Gualdoni1, T. Lingscheid2, K. G. Schmetterer1, A. Hennig1, P. Steinberger1, G. J. Zlabinger1;
1
Medical University Vienna, Vienna, Austria, 2Charité Universitätsmedizin, Berlin, Germany.
35
Monday
P.C.07.18
Cigarette smoking is associated with increased NLRP3-inflammasome activation
P.C.07.19
Impairment of mitochondrial electron transport chain provides a selective priming signal for NLRP3 inflammasome
P.C.07.20
Characterization of the role of NLRP10 in immune response
J. Öckinger1, M. Hagemann-Jensen1, S. Kullberg1,2, J. Grunewald1, F. Piehl1, T. Olsson1, J. Wahlström1;
1
Karolinska Institutet, Stockholm, Sweden, 2Karolinska University Hospital, Stockholm, Sweden.
E. Lee, J. Won, J. Yang, S. Son, S. Jeon, J. Yu;
Department of Microbiology, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea, Republic of.
M. Vacca, L. P. Zambetti, A. Mortellaro;
SIgN A*STAR, Singapore, Singapore.
Chairpersons: Dmitry Kuprash; Moscow, Russian Federation / Thomas Weichhart; Vienna, Austria
P.C.08.01
Alpha-1 antitrypsin is an efficient inhibitor of ATP-induced IL-1β release from human monocytes
R. Siebers1, S. Wilker1, M. Küllmar1, N. Aggarwal2, A. Zakrzewicz1, W. Padberg1, S. Janciauskiene2,3, V. Grau1;
Justus-Liebig-University Giessen, Laboratory of Experimental Surgery, Giessen, Germany, 2Hannover Medical School, Department of Pulmonology, Hannover, Germany, 3Member of the German Centre for
Lung Research, Giessen, Germany.
1
P.C.08.02
Regulation and interaction of Bcl2-A1/Bfl1: possible potent factor in immune signaling
P.C.08.03
Differential recruitment of β-arrestin 1 and 2 by atypical chemokine receptor ACKR2
P.C.08.04
Lyn-dependent activation of TAK1 and IKK2 is prerequisite to mediate effective mast cell effector functions induced by the c-Kit/IL-33R complex
P.C.08.05
Dengue Virus Induces Heat Shock Factor 1 Activation to Manipulate Autophagic Machinery for Virus Replication in Monocytes
H. K. Joshi, J. Zovko, I. Berberich;
Institute for immunobiology,University of Würzburg, Würzburg, Germany.
A. Vacchini1,2, C. Cancellieri2, S. Badanai1, A. Ferraro2, M. Busnelli3, B. Chini3, R. Bonecchi2, E. M. Borroni1, M. Locati1;
1
dep. Medical biotechnologies and Translational medicine, University of Milan, Milan, Italy, 2Humanitas Research Hospital, Rozzano, Italy, 3Institute of Neuroscience, National Research Council, Milan, Italy.
F. Weber1, C. Göpfert1, F. Boelke1, M. A. Diamanti2, N. Häfner3, F. R. Greten2, O. H. Krämer4, A. Dudeck5, T. Kamradt1, S. Drube1;
1
Institute of Immunology, University Hospital Jena, Jena, Germany, 2Georg-Speyer-Haus, Institute for Tumorbiology and Experimental Therapy, Frankfurt, Germany, 3Gynäkologische Molekularbiologie,
Klinik für Frauenheilkunde und Geburtshilfe, Jena, Germany, 4Institut für Toxikologie, Universitäts-Medizin Mainz, Mainz, Germany, 5Institut für Immunologie, Medizinische Fakultät “Carl Gustav Carus”,
Technische Universität Dresden, Dresden, Germany.
T. Tsai;
Department of Microbiology and Immunology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
P.C.08.06 Exploring the regulation of IL-27 production
S. Dunne, D. Bruni, C. Lyons, M. Butler;
Maynooth University, Kildare, Ireland.
P.C.08.07
Unique transcriptome changes in influenza A virus infected type 2 alveolar epithelial cells
C. J. Stairiker1,2, A. S. Hancock2, A. C. Boesteanu2, E. Monzon-Casanova3, S. Lukasiak3, Y. M. Mueller1,2, A. Stubbs1, M. Turner3, P. D. Katsikis1,2;
1
Erasmus University Medical Center, Rotterdam, Netherlands, 2Drexel University College of Medicine, Philadelphia, PA, United States, 3The Babraham Institute, Cambridge, United Kingdom.
P.C.08.08 Dissecting the dynamics of host molecular network in response to a viral infection
R. K. Kandasamy, G. I. Vladimer, B. Snijder, A. C. Mueller, M. Rebsamen, K. Bennett, G. Superti-Furga;
CeMM Center for Molecular Medicine, Vienna, Austria.
P.C.08.09 IPS-1 induces anticancer activity by differentially inducing apoptotic genes in type i interferons-dependent and -independent manner
S. Kumar;
Indian Institute of Science education and Research Bhopal, Bhopal, India.
P.C.08.10
Isolated lymphoid follicle formation depends on lymphotoxin-beta receptor signaling in a subpopulation of intestinal fibroblastic reticular cells
P.C.08.11
Specific phosphorylations transmit signals from leukocyte β2 to β1 integrins and regulate adhesion
P.C.08.12
Different regulatory roles of CSK and PAG adaptor protein in the FcεRI signaling
P.C.08.13
Targeting and sub-cellular localization of extracellular vesicles by phagocytic cells
P.C.08.14
Caffeine affects the biological responses of human myeloid hematopoietic cells
L. Onder1, U. Mörbe1, C. Gil-Cruz1, C. Perez-Shibayama1, H. Cheng1, T. Hehlgans2, T. Rülicke3, B. Ludewig1, E. Scandella1;
1
Kantonal Hospital St.Gallen, St.Gallen, Switzerland, 2University of Regensburg, Regensburg, Germany, 3Institute of Laboratory Animal Science and Biomodels Austria, University of Veterinary Medicine
Vienna, Austria.
F. A. Jahan, L. M. Uotila, L. S. Hinojosa, E. Melandri, M. Grönholm, C. G. Gahmberg;
University of Helsinki, Helsinki, Finland.
L. Potůčková, L. Dráberová, P. Dráber;
Institute of Molecular Genetics of the ASCR, Prague, Czech Republic.
E. S. Kayali1, D. Bayik1,2, T. Kahraman1, G. Gucluler1, I. Gursel1;
1
Bilkent University, Ankara, Turkey, 2National Cancer Institute, Frederick, MD, United States.
I. Gonçalves Silva1, B. F. Gibbs1, A. Prokhorov1, M. Abooali1, I. Yasinska1, M. A. Casely-Hayford1, E. Fasler-Kan2, V. Sumbayev1;
1
School of Pharmacy, University of Kent, Chatham, United Kingdom, 2Department of Biomedicine, University of Basel, Basel, Switzerland.
Chairpersons: Hildegard Greinix; Vienna, Austria / Paul Moss; Birmingham, United Kingdom
P.D.01.01
Transcriptome analysis of circulating lymphoid progenitors after allogeneic stem cell transplantation in humans reveals profound alterations of cellular
metabolism
S. Glauzy1, I. André-Schmutz2, J. Lachuer3, R. Peffault de Latour4, S. Servais4, G. Socié5, E. Clave1, A. Toubert1;
INSERM U1160, Université Paris Diderot Sorbonne Paris Cité; Laboratoire d’Immunologie, Hôpital Saint-Louis AP-HP, Paris, France, 2Inserm U768, Institut Imagine; Univ Paris Descartes, Sorbonne Paris
Cité, Hôpital Necker, Paris, France, 3ProfileXpert, Univ UMR1052, CRCL, UCBL, Lyon, France, 4Université Paris Diderot Sorbonne Paris Cité; Service d’Hématologie-Greffe de Moelle, Hôpital Saint-Louis,
AP-HP, Paris, France, 5INSERM U1160; Université Paris Diderot Sorbonne Paris Cité; Service d’Hématologie-Greffe de Moelle, Hôpital Saint-Louis, AP-HP, Paris, France, Paris, France.
1
P.D.01.02
Assessing the role of mannan-binding lectin in T cell reactivity and graft-versus-host disease
P.D.01.03
Short term hypoxia does not attenuate the immune suppressive capacity of mesenchymal stem cells
D. Heja1, S. Heitzeneder2, A. M. Dohnal1;
1
Children´s Cancer Research Institute, Vienna, Austria, 2Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, United States.
L. Cahill;
Institute of Immunology, Maynooth, Ireland.
P.D.01.04 Tregs induce mixed chimerism by suppressing recipient NK cells
B. Mahr, N. Pilat, K. Hock, C. Schwarz, L. Unger, A. M. Farkas, T. Wekerle;
P.D.01.05
36
The activating NKG2C receptor is significantly reduced in NK cells after allogeneic stem cell transplantation in patients with severe Graft-versus-host disease
V. Rebmann1, P. A. Horn1, D. Beelen2, L. Kordelas2;
1
Institute for Transfusion Medicine, University Hospital Essen, Essen, Germany, 2Department of Bone Marrow Transplantation, University Hospital Essen, Essen, Germany.
P.D.01.07
Thymic function recovery and memory B- and T-cell depletion after autologous hematopoietic stem cell transplantation in systemic sclerosis patients
L. C. Arruda1,2, D. Farge3,4,5, C. Douay4,5, E. Clave4,5, I. Fournier6, H. Moins-Teisserenc4,5,6, A. Toubert4,5,6;
1
National Institute of Science and Technology in Stem Cells and Cell Therapy, Regional Hemotherapy Center of the Ribeirão Preto Medical School, Ribeirão Preto, Brazil, 2Department of Biochemistry
and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil, 3Service de Médecine Interne, Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France,
4
Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d’Hématologie, Paris, France, 5Institut National de la Santé et de la Recherche Médicale UMR1160, Paris, France, 6Laboratoire
d’Immunologie et d’Histocompatibilité, Paris, France.
I. V. Zvyagin1,2, I. Z. Mamedov1, E. A. Komech1, O. Tatarinova3, M. Maschan3, D. M. Chudakov1,2, Y. B. Lebedev1;
1
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of RAS, Moscow, Russia, Moscow, Russian Federation, 2Central European Institute of Technology (CEITEC), Brno, Czech Republic, 3Dmitry
Rogachev Federal Clinical Research Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation.
P.D.01.09 Th17, Tc17 and Tregs in pediatric allogeneic stem cell transplantation: associations with IL-7 and aGvHD
K. Kielsen1, D. Lennox-Hvenekilde2, K. K. Jordan1, H. H. Uhlving1, P. L. Pontoppidan2,1, M. Gad3, M. Ifversen1, C. Heilmann1, H. Sengeløv1, C. H. Nielsen1, L. P. Ryder1, A. E. Pedersen2, K. Müller1;
Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark, 2University of Copenhagen, Copenhagen, Denmark, 3Bioneer A/S, Hørsholm, Denmark.
1
P.D.01.10
The identification and pathological roles of IL-22 in acute graft-versus-host disease following allogeneic bone marrow transplantation
P.D.01.11
Variation in immune cell composition of allogenic hematopoietic stem cell grafts and its contribution to transplantation
P.D.01.12
Protective role of bone marrow derived mesenchymal stem cells-conditioned medium in the infarcted myocardium: the potential role of selected cytokines
P.D.01.13
The influence of conditioning regimen on regulatory T cell reconstitution following autologous stem cell transplantation (ASCT)
P.D.01.14
CD27- IgD- ‘Double negative’ B-cells detected early after reduced intensity lymphocyte-depleted haematopoietic stem cell transplantation are phenotypically
senescent and reduced in patients who develop chronic GvHD
K. Zhao, C. Chen, B. Pan, L. Zeng, K. Xu;
Blood Disease Institute, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
Monday
P.D.01.08 Deep sequencing analysis of T cell repertoire reconstitution after hematopoietic cells transplantation
U. Impola1, A. Larjo1, M. Putkonen2, U. Salmenniemi2, M. Itälä-Remes2, J. Partanen1;
1
Finnish Red Cross Blood Service, Helsinki, Finland, 2Turku University Hospital, Turku, Finland.
N. Aboutaleb1,2, M. Gandizadeh Dezfouli1, K. Rakhshan3, T. Mousavi Shabestari4;
1
Physiology research centre, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 2department of Physiology, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of,
3
department of Physiology, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 4Department of Immunology, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
A. Chwieduk, M. Glowala-Kosinska, W. Fidyk, I. Mitrus, A. Smagur, J. Najda, S. Giebel;
Dept. of Bone Marrow Transplantation and Oncohematology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland.
H. Protheroe1, F. A. Kinsella1,2, H. Pearce1, C. Inman1, S. Eldershaw1, J. Croudace1, B. Abbotts1, J. Zuo1, R. Malladi1,2, P. Moss1,2;
1
University of Birmingham, Birmingham, United Kingdom, 2Centre for Clinical Haematology, Queen Elizabeth NHS Foundation Trust, Birmingham, United Kingdom.
Chairpersons: Brigitte Autran; Paris, France / Ed Lavelle; Dublin, Ireland
P.D.02.01
Immunogenic and vaccine potential of immunodominant B-cell epitope of OmpF of Aeromonas hydrophila in translational fusion with heat-labile enterotoxin B
subunit of E. coli
M. Sharma, A. Dixit;
Jawaharlal Nehru University, New Delhi, India.
P.D.02.02
Prevention of allergic asthma through Der p 2 peptide vaccination
P.D.02.03
L1-RG1 virus-like particle (VLP) vaccines directed against cutaneous human papillomaviruses (HPV)
G. Bouchaud1,2, F. Braza2, J. Chesné2, D. Lair2, K. Chen3, C. Rolland-Debord2, D. Hassoun2, T. Bihouée2, M. Cheminant2, S. Brouard4, M. Bodinier1, S. Vrtala3, A. Magnan2;
1
INRA BIA UR1268, Nantes, France, 2UMR INSERM1087/CNRS6291, Institut du Thorax, Nantes, France, 3Department of Pathophysiology and Allergy Research, Vienna, Austria, 4INSERM U1064, Institut de
Transplantation Urologie Néphrologie, Nantes, France.
B. Huber, C. Schellenbacher, C. Jindra, S. Shafti-Keramat, R. Kirnbauer;
Laboratory of Viral Oncology (LVO), Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Medical University Vienna (MUW), Vienna, Austria.
P.D.02.04 Built-in adjuvanticity of genetically and protein engineered chimeric molecules for targeting of Influenza A peptide epitopes
N. Kerekov1, I. Ivanova1, N. Mihaylova1, M. Nikolova2, J. Prechl3, A. I. Tchorbanov1;
1
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria, 2National Reference Laboratory of Immunology, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria,
3
Immunology Research Group, Hungarian Academy of Sciences, Budapest, Hungary.
P.D.02.05
Targeting of Influenza viral epitopes to human antigen presenting cells by genetically engineered chimeric molecules
I. I. Ivanova1, N. Mihaylova1, D. Hlebarska1, I. Manoylov1, D. Makatsori2, A. Mamalaki2, J. Prechl3, A. Tchorbanov1;
1
Laboratory of Experimental Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria, 2Hellenic Pasteur Institute, Athens, Greece, 3Immunology Research Group, Hungarian
Academy of Sciences, Budapest, Hungary.
P.D.02.06 The Project Immunology at Schools boosted by the Day of Immunology: Tools for Education in Immunology in Brazil
J. M. do Carmo1, Y. T. dos Santos2, J. A. Silva Junior2, J. M. Cunha2, K. E. de Jesus2, M. S. Vieira2, P. V. Guerra2, S. M. Viana2, D. Manzoni3, T. C. Bessa2, R. R. Oliveria2;
Instituto Tocantinense Presidente Antônio Carlos, Porto Nacional, Brazil, 2CPqGM-FIOCRUZ-Bahia, Salvador, Brazil, 3Universidade de São Paulo, São Paulo, Brazil.
1
P.D.02.07
Magnified and persistent Th1-biased anti-OVA immunity mediated by co-encapsulated adjuvant and antigen in exosomes
T. Kahraman, G. Gucluler, I. Gursel;
P.D.02.08 Therapeutic potential of lymphatic endothelial progenitors for the treatment of filarial induced lymphedema
A. Setty Balakrishnan1,2, A. Arul Nathan1,3, S. Babu4, M. Dixit5;
1
Madurai Kamaraj University, Madurai, India, 2Department Of Genetic Engineering, School Of Biotechnology, Madurai, India, 3Det of Genetic Engineering, Schoo of Biotechnology, Madurai, India, 42. NIHICER, National Institute for Research in Tuberculosis (NIRT),, Chennai, India, 53. Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India.
P.D.02.09 Prediction of conserved immunogenic peptides containing overlapping CD4+ and CD8+ T cell epitopes in H1N1 Matrix 1 Protein: An immunoinformatics approach
N. Lohia, M. Baranwal;
Thapar university, India, Patiala, Punjab, India.
P.D.02.10
Hepatitis B-specific immune responses in grass pollen allergic patients immunized with the preS-based grass pollen allergy vaccine BM32
P.D.02.11
Multiple antigens of Hepatitis C Virus delivered by recombinant vaccinia virus induces robust and long-term immunity in BALB/c mice
P.D.02.12
Characterization of cellular and humoral immune responses induced by immunization with a rPotD-PdT hybrid protein
C. Cornelius1, K. Schöneweis2, M. Weber1, K. Niespodziana1, M. Trauner3, H. Hofer3, S. Urban2, R. Valenta1;
1
Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria, 2Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg,
Germany, 3Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.
Y. Deng, W. Wang, J. Guan, H. Chen, W. Wang, W. Tan;
National Institute for Viral Disease Control and Prevention，China CDC, Beijing, China.
T. R. Converso1,2, C. Goulart1,2, D. Rodriguez1, M. Darrieux3, L. C. Leite1;
Centro de Biotecnologia, Instituto Butantan, São Paulo, Brazil, 2Programa de Pós-Graduação Interunidades em Biotecnologia – USP-IB-IPT, São Paulo, Brazil, 3Laboratório de biologia molecular e
farmacologia, Universidade São Francisco, Bragança Paulista, Brazil.
1
P.D.02.13
Closing the gap between bench and bedside: Manufacturing individual multi-peptide vaccines for phase I/II clinical trials in cancer immunotherapy
P.D.02.14
Protective efficacy of the conserved NP, PB1, and M1 proteins as immunogens in DNA- and vaccinia virus-based universal influenza A virus vaccines in mice
P.D.02.15
Long-term protective effect and immune memory response induced by attenuated antigen against scorpion envenoming
M. Stieglbauer1,2, P. Hrstić1,2, N. Zuschke1, K. Graf1,2, S. Stevanović1, H. Rammensee1,2;
1
Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany, 2German Cancer Consortium (DKTK), Tübingen, Germany.
W. Wang1, R. Li1,2, Y. Deng1, N. Lu1, H. Chen1, X. Meng1, W. Wang1, X. Wang1, K. Yan1, X. Qi1, X. Zhang1, W. Xin1, Z. Lu1, X. Li1, T. Bian1, Y. Gao1, W. Tan1, L. Ruan1;
1
National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Pr, Beijing, China, 2Institute of Immunization and Prevention, Beijing Center for Disease Control and
Prevention, Beijing, China.
L. Boussag-Abib, F. Rebbouh, F. Laraba-Djebari;
USTHB, Faculté des Sciences Biologiques, Laboratoire de Biologie Cellulaire et Moléculaire, Bab Ezzouar, Algeria.
37
P.D.02.16 Vaccination with rRBD Protein Induces Neutralising Antibodies in Rhesus Macaques and Confers Limited Protection Against MERS-CoV Challenge
Y. Deng1, W. Tan1, J. Lan1, Y. Yao2, H. Chen1, W. Wang1, W. Wang1, G. Lu3, L. Bao2, W. Deng2, Q. Wei2, G. F. Gao3, C. Qin2;
1
National Institute for Viral Disease Control and Prevention，China CDC, Beijing, China, 2Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine
Center, Peking Union Medical Collage (PUMC); Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing, China, Beijing, China, 3CAS Key Laboratory of Pathogenic Microbiology
and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China, Beijing, China.
P.D.02.17
Epitope mapping for prediction of T cell epitope of proteins of mymA operon binding to MHC Class I alleles
Monday
I. Saraav, S. Singh, K. Pandey, M. Sharma, S. Sharma;
D S Kothari Centre for Research and Innovation Science Education, Miranda House, Delhi, India.
P.D.02.18 Effects of adjuvant, mouse strain and dose regimen on immune responses in mice immunized with a meningococcal A+W outer membrane vesicle (OMV) vaccine
G. Tunheim1, M. Arnemo2,1, K. Bolstad1, Å. K. Fjeldheim1, K. Sinnadurai1, L. M. Næss1, G. Norheim1, A. Mandiarote3, D. Gonzalez3, L. Garcia3, T. Gjøen2, E. Rosenqvist1;
1
Norwegian Institute of Public Health, Oslo, Norway, 2Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway, 3Finlay Institute, Havana, Cuba.
P.D.02.19 Mono- and bivalent anti-PCSK9 vaccines for the treatment of hypercholesterolemia.
G. Galabova, C. Juno, A. Mairhofer, A. von Bonin, G. Staffler;
AFFiRiS AG, Vienna, Austria.
P.D.02.20
Nanocapsules integrating biomaterials for vaccine delivery: influence of the polymeric coating on the interaction with the immune system
M. Peleteiro Olmedo1, E. Presas2, J. González Aramundiz2, B. Sánchez Correa1, R. Simón Vázquez1, N. Csaba2, M. Alonso Fernández2, Á. González Fernández1;
University of Vigo, Vigo, Spain, 2University of Santiago de Compostela, Santiago de Compostela, Spain.
1
P.D.02.21
Testing microcrystalline tyrosine (MCT) as adjuvant for vaccine against malaria (P. vivax)
P.D.02.22
Empowering educators with vaccination-related knowledge: a French community-based mediation program
P.D.02.23
Effect of color Doppler ultrasound guided dendritic cell vaccine injection on the level of CD4+CD25+Treg cells in tumor patients
P.D.02.24
Development of therapeutic cancer vaccines targeting tumor-specific matrix proteins
G. Cabral de Miranda1, A. El-Turabi1, M. A. Skinner2, S. Hewings2, A. C. Gomes1, E. Montoya-Diaz1, A. Reyes-Sandoval1, M. F. Bachmann1;
1
Centre for Cellular and Molecular Physiology (CCMP); The Jenner Institute; University of Oxford; Oxf, Oxford, United Kingdom, 2Allergy Therapeutics, Brighton, United Kingdom.
C. Journo1,2, C. H. Eyraud3, V. Charbonnier3, G. Vidal3, F. Morel-Deville3, N. Davoust1,4;
1
Département de Biologie, ENS de Lyon, Lyon, France, 2Equipe Oncogenèse Rétrovirale, labellisée “Ligue Nationale Contre le Cancer”, Centre international de recherche en infectiologie, INSERM U1111 CNRS UMR5308, Lyon, France, 3Institut Français de l’Education, ENS de Lyon, Lyon, France, 4Laboratoire de Biologie Moléculaire de la Cellule, UMR5239, Lyon, France.
W. Huang, S. Jia, J. Hu, L. Jiang;
The 81st hospital of PLA, NanJing, China.
F. Saupe1, E. Huijbers1, J. Femel1, L. Hellman2, A. Olsson1;
1
Uppsala University / IMBIM, Uppsala, Sweden, 2Uppsala University / ICM, Uppsala, Sweden.
Chairpersons: Ursula Wiedermann; Vienna, Austria / Armin Saalmüller; Vienna, Austria
P.D.03.01
Novel approach to therapeutic vaccination for bacterial infection
P.D.03.02
The potency of adaptive immunity against conserved and evolving antigens
P.D.03.03
CCR2 deficiency promotes Tfh polarization for mucosal IgA induction after intradermal immunization
P.D.03.04
Targeting DC-SIGN as a vaccination strategy against mycobacteria
E. D. Williamson, I. J. Thompson, R. Page, C. A. Rowland, G. C. Clark;
DSTL Porton Down, Salisbury, United Kingdom.
J. Nowak1, D. Augustyniak2, R. Figura2, B. Borkowska1, J. Roszkowiak2, Z. Drulis-Kawa2, B. Pawlowski1;
1
Department of Human Biology, University of Wroclaw, Wroclaw, Poland, 2Department of Pathogen Biology and Immunology, University of Wroclaw, Wroclaw, Poland.
O. Bonduelle1,2, B. Bellier3,4,5, L. Chonco1,2, T. Vazquez3,4,5, C. Levin1,2, F. Pitoiset3,4,5, C. Nuttens1,2, C. Combadière1,2, B. Combadière1,2;
1
Sorbonne Universités, UPMC Univ Paris 06, Unité Mixte de Recherche de Santé (UMR S) CR7, Centre d’Immunologie et de Maladies Infectieuses – Paris (Cimi-Paris), Paris, France, 2Institut National de
Santé et de Recherche Médicale (INSERM) U1135, Cimi-Paris, Paris, France, 3Sorbonne Universités, UPMC Univ Paris 06, UMRS 959, I3, Paris, France, 4INSERM, UMRS 959, Paris, France, 5CNRS, FRE3632,
Paris, France.
P. Stüve1, M. Swallow1, C. Hesse1, W. Unger2, Y. van Kooyk2, T. Sparwasser1, L. Berod1;
Institute of Infection Immunology, TWINCORE, Hannover, Germany, 2Dept. of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, Netherlands.
1
P.D.03.05
Development of a novel heat shock protein-enriched pneumococcal vaccine
W. Chan1, P. Cecchini2, C. Entwisle2, C. Bailey2, J. X. Wheeler3, J. S. Brown1;
1
Centre for Inflammation and Tissue Repair, Division of Medicine, UCL, London, United Kingdom, 2ImmunoBiology Ltd., Babraham Research Campus, Cambridge, United Kingdom, 3NIBSC, MHRA, South
Mimms, Hertfordshire, United Kingdom.
P.D.03.06 Children 4 years of age reporting local adverse events after the 5th DTaP-IPV vaccination show elevated immune responses to several vaccine antigens
S. van der Lee1, J. M. Kemmeren1, L. G. de Rond1, K. Öztürk1, A. Westerhof1, H. E. de Melker1, G. A. Berbers1, N. A. van der Maas1, H. C. Rümke2, A. Buisman1;
1
National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands, 2Pharmacovigilance Centre LAREB, ‘s-Hertogenbosch, Netherlands.
P.D.03.07
Changing the delivery route of DNA vaccines to Respiratory Syncytial Virus (RSV) can lead to diverse outcomes after infection from vaccine enhanced disease to
protection
E. Kinnear1, L. J. Caproni2, J. S. Tregoning1;
1
Imperial College London, London, United Kingdom, 2Touchlight Genetics, Leatherhead, United Kingdom.
P.D.03.08 Characterisation of the Immunological responses in chickens infected with influenza A/Duck/Laos/XBY004/2014 (H5N6), a new reassortant highly pathogenic
avian influenza type
J. Butler1, C. Stewart1, D. Layton1, M. Bruce1, C. Rootes1, A. Rohringer1,2, T. Gough1, S. Fardy1, A. Karpala1, S. Shan1, S. Valdeter1, S. Walker1, J. Wang1, F. Y. Wong1, D. T. Williams1, A. G. Bean1, J. Bingham1;
CSIRO - AAHL, Geelong, Australia, 2Deakin University, Geelong, Australia.
1
P.D.03.09 The evaluation of candidate biomarkers of cell-mediated immunity for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer)
W. J. Goosen, M. A. Miller, R. M. Warren, P. D. van Helden, S. D. Parsons;
Stellenbosch University, Cape Town, South Africa.
P.D.03.10
Comparative Analysis of the Cytokine Pattern Production in Human and Canine Monocyte Derived Dendritic Cells Against Infection with Brucella canis
P.D.03.11
Immunomodulatory Effects of Canine Adipose-Derived Mesenchymal Stem Cells
P.D.03.12
Characterisation of mononuclear cells in the Tasmanian devil (Sarcophilus harrisii) by generating monoclonal antibodies
P.D.03.13
Immunogenicity and protective efficacy of a recombinant adenoviral based vaccine expressing heat-stable enterotoxin (STa) and K99 adhesion antigen of
Enterotoxigenic Escherichia coli in mice
M. Pujol1, C. Alvarez2, J. Arias2, M. Fresno1, C. Rojas2, A. Ferreira3, R. Vernal2;
1
Facultad de Ciencias Silvoagropecuarias y Veterinarias, Universidad de Chile, Santiago, Chile., Santiago, Chile, 2Facultad de Odontología, Universidad de Chile, Santiago, Chile, 3Facultad de Medicina,
Universidad de Chile, Santiago, Chile., Santiago, Chile.
J. Lee, J. Byeon, N. Gu, H. Kim, G. Lee, S. Cha;
Animal and Plant Quarantine Agency, Anyang-si, Korea, Republic of.
G. Kalodimos1, C. Tovar1, J. Darby1, A. B. Lyons2, G. M. Woods1;
1
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, 2School of Medicine, University of Tasmania, Hobart, Australia.
G. Deng;
Ningxia University, Yinchuan, China.
P.D.03.14
38
Isolation and Characterization of Feline Mesenchymal Stem Cells
J. Lee, H. Kim, N. Gu, G. Lee, J. Byeon, S. Cha;
Chairpersons: David Hafler; New Haven, United States / Lotta Jansson; Diepenbeek, Belgium
P.D.04.01 Establishing cut-off of infliximab levels and anti-infliximab antibodies by commercial ELISA in patients with rheumatoid arthritis
P.D.04.02 Anti-TNF-α therapy for RA affect LIGHT/HVEM/BTLA signaling pathway in patients with rheumatoid arthritis
B. Yang;
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
P.D.04.03
Anti-tumor necrosis factor therapy restores peripheral blood B cell subsets and CD40 expression in inflammatory bowel diseases
Z. Li1, S. Vermeire1, D. Bullens1, M. Ferrante1, K. Van Steen1,2, M. Noman1, X. Bossuyt1, P. Rutgeerts1, J. L. Ceuppens1, G. Van Assche1;
1
Catholic University of Leuven, Leuven, Belgium, 2Université de Liège, Liège, Belgium.
P.D.04.04 Autoimmune hepatitis in a murine APS-1 model is directed against multiple autoantigens and can be controlled by polyspecific Tregs
M. Hardtke-Wolenski1, R. Taubert1, F. Noyan1, M. Sievers1, J. Dywicki1, J. Schlue1, C. S. Falk1, B. Ardesjö Lundgren2, H. S. Scott3, A. Pich1, M. S. Anderson4, M. P. Manns1, E. Jaeckel1;
1
Hannover Medical School, Hannover, Germany, 2Uppsala University, Uppsala, Sweden, 3Centre for Cancer Biology, Adelaide, Australia, 4University of California – San Francisco, San Francisco, CA, United
States.
Monday
D. Hernández-Flórez, L. Valor, J. Nieto, T. del Rio, I. de la Torre, C. Gonzalez, E. Naredo, J. López-Longo, I. Monteagudo, L. Carreño;
Hospital General Universitario Gregorio Marañón, Madrid, Spain.
P.D.04.05 Neutralization of autoreactive T cells by monoclonal antibody in pristane-induced mouse model of Systemic lupus erythematosus
N. Mihaylova1, S. Bradyanova1, P. Chipinski1, S. Chausheva1, M. Herbáth2, F. D’Acquisto3, J. Prechl2, A. I. Tchorbanov1;
1
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria, 2Immunology Research Group, Hungarian Academy of Sciences, Budapest, Hungary, 3Centre for Biochemical Pharmacology,
William Harvey Research Institute, Charterhouse Square, London, United Kingdom.
P.D.04.06 Targeting dihydroorotate dehydrogenase for treating relapsing-remitting and chronic experimental autoimmune uveitis
M. Diedrichs-Möhring1, J. Leban2, S. Strobl2, F. Obermayr3, G. Wildner1;
1
Klinikum der LMU, Munich, Germany, 24SC Discovery GmbH, Planegg-Martinsried, Germany, 3Panoptes Pharma GmbH, Vienna, Austria.
P.D.04.07 Effects of epratuzumab, a monoclonal antibody targeting human CD22, on B cell function in human CD22 knock-in mice
L. Özgör1, C. Brandl1, M. Wöhner2, A. Shock3, L. Nitschke1;
1
Friedrich-Alexander University, Erlangen, Germany, 2Research Institute of Molecular Pathology, Vienna, Austria, 3UCB, Slough, United Kingdom.
P.D.04.08 IL-7 receptor blockade prevents intestinal human T cells infiltration by modulation of alpha4-beta7 integrin expression
L. Belarif1, N. Poirier1, V. Daguin2, G. Blancho2, B. Vanhove1;
1
EFFIMUNE, Nantes, France, 2INSERM UMR 1064, Nantes, France.
P.D.04.09 Preclinical efficacy of anti-IL7 receptor monoclonal antibodies in non human primate
N. Poirier1, L. Belarif1, H. Mai Le2, C. Mary1, J. Hervouet2, D. Minault2, V. Thepenier1, S. Le Bas-Bernardet2, E. NGUYEN2, J. Soulillou2, S. Brouard2, G. Blancho2, B. Vanhove1;
1
EFFIMUNE, Nantes, France, 2INSERM UMR 1064, Nantes, France.
P.D.04.10 Selective CD28 blockade controls imiquimod-induced psoriasiform skin inflammation in non-human primates
N. Poirier1, M. Chevalier2, J. Hervouet2, D. Minault2, C. Mary1, L. Belarif1, E. Cassagnau3, B. Vanhove1, G. Blancho2;
1
EFFIMUNE, Nantes, France, 2INSERM UMR 1064, Nantes, France, 3CHU Hotel Dieu, Nantes, France.
P.D.04.11
Expression of indoleamine-2,3-dioxygenase only during inflammation state: Initial study to develop novel strategy for the treatment of rheumatoid arthritis
M. Karaçay1,2, A. Ö. Barazi3, M. Pashazadeh4, F. Güvenç5, F. Ersoy1,1, H. B. Oral6;
1
Department of Molecular Biology & Genetics, Faculty of Arts & Sciences, Uludag University, Bursa, Turkey, 2Department of Biology/Molecular Biology, Institute of Natural Sciences, Uludag University,
Bursa, Turkey, 3Department of Immunology, Institute of Health Sciences, Gazi University, Ankara, Turkey, 4Department of Microbiology/Immunology, Institute of Health Sciences, Uludag University, Bursa,
Turkey, 5Life Sciences Program, Immunology, Toronto University, Toronto, ON, Canada, 6Department of Immunology, Faculty of Medicine, Uludag University, Bursa, Turkey.
P.D.04.12 Impact of IgG sialylation for anti-inflammatory activity of intravenous immunoglobulin
I. Schwab, F. Nimmerjahn;
Institute of Genetics, Department Biology, University of Erlangen-Nürnberg, Erlangen, Germany.
P.D.04.13
Efficacy of low-dose rituximab for the treatment of mixed cryoglobulinemia vasculitis: phase II clinical trial
M. Visentini1, C. Tinelli2, M. Monti3, J. Ranieri3, L. Gragnani3, S. Ludovisi4, S. Colantuono1, M. Mitrevski1, M. U. Mondelli4, A. Zignego3, M. Fiorilli1, M. Casato1;
Sapienza, University of Rome, Rome, Italy, 2Clinical Epidemiology and Biometric Unit, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, 3Research Center for Systemic Manifestations of Hepatitis
Viruses, Department of Internal Medicine, University of Florence, Florence, Italy, 4Infectious Diseases Research Laboratories, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
1
P.D.04.14 Differential role of antigen presenting cells in the induction of Th3 cells and oral tolerance
C. Kuhn1,2, R. Machado Rezende1,2, S. Rubino1,2, H. L. Weiner1,2;
1
Brigham and Women’s Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States.
P.D.04.15
The mechanism of encephalomyelitis remission during Heligmosomoides polygyrus infection in C57BL/6 mice
K. Krawczak, K. Donskow-Łysoniewska, M. Doligalska;
University of Warsaw, Warsaw, Poland.
P.D.04.16 Interleukin-22 reduced liver inflammation and fibrosis in primary biliary cirrhosis
Y. Chuang;
P.D.04.17
Targeting of antigen into XCR1+ dendritic cells effectively induces tolerance
N. Reeg, A. Jäkel, S. Gurka, H. W. Mages, R. A. Kroczek;
Robert Koch-Institute, Berlin, Germany.
Chairpersons: Mübeccel Akdis; Davos, Switzerland / Rudolf Valenta; Vienna, Austria
P.D.05.01
Immunotherapy of allergic patients with the B cell epitope-based recombinant grass pollen allergy vaccine BM32 induces allergen-specific IgG antibodies which
inhibiting immediate allergic inflammation and allergen-specific T cell responses
M. Focke-Tejkl1, M. Weber1, R. Zieglmayer2, P. Lemell2, F. Horak2, A. Neubauer3, F. Stolz3, H. Huber3, R. Henning3, R. Valenta1;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna, Vienna, Austria, 2Vienna
Challenge Chamber, Vienna, Austria, 3Biomay AG, Vienna, Austria.
P.D.05.02
Mechanisms of the suppression of asthmatic responses in mice by Fab fragments of a pathogenic allergen-specific monoclonal antibody IgG1
P.D.05.03
Novel drug design for birch pollen and associated food allergies
S. Yoshino, N. Mizutani;
Kobe Pharmaceutical University, Kobe, Japan.
H. Hofer1, C. Asam1, M. Hauser1, P. Briza1, M. Himly1, C. Ebner2, F. Ferreira1, M. Wallner1;
Department of Molecular Biology, University of Salzburg, Salzburg, Austria, 2Allergieambulatorium, Vienna, Austria.
1
P.D.05.04 The C1Q regulatory dendritic cell marker is a potent inhibitor of allergic inflammation
L. Mascarell, S. Airouche, E. Nony, V. Bodo, P. Moingeon;
Stallergenes, Antony, France.
P.D.05.05
Development of a mouse model to study tolerance induction to the major fish allergen parvalbumin
R. Freidl1, U. Baranyi2, I. Swoboda1, M. Focke-Tejkl1, R. Valenta1, B. Linhart1;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Department
of Surgery, Medical University of Vienna, Vienna, Austria.
P.D.05.06 Skin test evaluation of a novel virus carrier-based vaccine, BM32, in grass pollen allergic patients
V. Niederberger1, K. Marth1,2, J. Eckl-Dorna1, M. Focke-Tejkl2, M. Weber2, W. Hemmer3, U. Berger1, A. Neubauer4, R. Henning4, R. Valenta2;
Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria, 2Division of Immunopathology, Department of Pathophysiology and Allergy Research, Centre for Pathophysiology,
Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 3FAZ – Floridsdorf Allergy Center, Vienna, Austria, 4Biomay AG, Vienna, Austria.
1
39
P.D.05.07
Selective elimination of allergen-specific B lymphocytes with chimeric protein-engineered molecule in humanized SCID model
N. Kerekov1, A. Michova2, G. Nikolov2, M. Muhtarova2, B. Petrunov2, M. Nikolova2, A. I. Tchorbanov1;
1
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria, 2National Reference Laboratory of Immunology, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
P.D.05.08 Increased basophil allergen sensitivity is associated with adverse systemic reactions during the build-up phase of honeybee venom immunotherapy
P. Korosec, K. Žiberna, M. Šilar, M. Dežman, N. Smodiš, M. Rijavec, P. Kopač, R. Eržen, N. Lalek, N. Bajrović, M. Košnik, M. Zidarn;
University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.
Monday
P.D.05.09 Conversion of Der p 23, a new major house dust mite allergen, into a hypoallergenic vaccine
S. Banerjee1, M. Weber1, K. Blatt2, I. Swoboda1, M. Focke-Tejkl1, P. Valent2, R. Valenta1, S. Vrtala1,3;
1
Department of Pathophysiology and Allergy Research, Vienna, Austria, 2Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna,, Vienna, Austria,
3
Christian Doppler Laboratory for the Development of Allergen Chips, Vienna, Austria.
P.D.05.10
Allergen-specific immunotherapy (SIT) induce sialylated immunosuppressive IgG antibodies
P.D.05.11
IgG4, but not IgG1, drive macrophages to release cortisol and IL-10 - implications in the mechanism of allergen immunotherapy
J. Hobusch1, C. M. Oefner2, A. Winkler2, C. Hess2, W. Pfützner3, C. Möbs3, A. Petersen4, U. Jappe4, D. Petzold5,2, Y. Bartsch1, M. Ehlers1,2;
1
Institute for Inflammation Research, University of Luebeck, Luebeck, Germany, 2German Rheumatism Research Center, Leibniz Institute, Berlin, Germany, 3Depatment of Dermatology and Allergology,
Phillips University, Marburg, Germany, 4Depatment of Clinical & Molecular Allergology, Research Center Borstel, Borstel, Germany, 5Charité University Medicine, Berlin, Germany.
R. Bianchini1, F. Roth-Walter1, L. Glenk1, R. Palme2, G. Roth3, G. Hofstetter1, S. Wagner1, K. Hufnagl1, E. Jensen-Jarolim1,4;
Dept. of Comparative Medicine, Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria, 2Unit of Physiology,
Pathophysiology and Experimental Endocrinology, University of Veterinary Medicine Vienna, Vienna, Austria, 3Dept. of Anesthesiology, General Intensive Care and Pain Medicine, Medical University Vienna,
Vienna, Austria, 4Dept. of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Vienna, Austria.
1
P.D.05.12
PACIFIC (Prospective Allergy and Immune Function Cohort): Induction of Th2 associated regulatory T cells during specific immunotherapy
P.D.05.13
Single allergen-induced oral tolerance inhibits airway inflammation in conjugated allergen immunized mice
P.D.05.14
Non interventional 2 year study of sublingual immunotherapy (SLIT) in children with allergic rhinitis and asthma
K. Dietz1, U. Zissler1, F. Braza1, K. Suttner1, F. Guerth1, Z. Hajdu2, C. Schmidt-Weber1, A. Chaker1,2;
1
ZAUM - Centre of Allergy and Environment, Technische Universität München (TUM), Helmholtz Centre Munich and member of German Centre for Lung Research (DZL), München, Germany, 2Department of
Otolaryngology, Allergy Section, Klinikum Rechts der Isar, Technische Universität München (TUM), München, Germany.
C. H. Chien1, H. H. Yu2, B. L. Chiang1,2;
1
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, 2Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan.
I. Filipovic1, M. Stojanovic2, D. Filipovic3;
1
Faculty of Medical Science, Kragujevac, Serbia, 2Clinic of Allergy and Clinical Immunology, Clinical Center of Serbia,, Belgrade, Serbia, 3Emergecy institute Belgrade, Belgrade, Serbia.
Chairpersons: Wolfgang Holter; Vienna, Austria / Lorenzo Mortara; Varese, Italy
P.D.06.01 Redirection of potent anti-viral CD8 T-cell immunity as a novel immunotherapeutic strategy against cancer
L. Morton, D. Millar, M. C. Gaspar, P. Mistry, M. Cobbold;
P.D.06.02 Activation of CD8+ effector memory T cells and the control of myeloid-derived suppressor cells promote protection against HPV-16-associated tumors
M. O. Diniz, N. S. Sales, J. R. Silva, L. C. Ferreira;
Institute of Biomedical Sciences, Univerity of Sao Paulo, Sao Paulo, Brazil.
P.D.06.03 Proteomic analysis of a heat-conditioned cancer cell lysate used for DC-based immunotherapy
F. González1, C. Pereda1, A. Chernobrovkin2, C. Fuentes1, J. López1, F. Salazar-Onfray1, R. Zubarev2;
1
Millennium Institute on Immunology and Immunotherapy, University of Chile, Santiago, Chile, 2Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockolm, Sweden.
P.D.06.04 Linking Glioblastoma Multiforme microRNA profiles with a potential susceptibility to Dendritic Cell-based cancer immunotherapy
F. Erhart1, A. M. Dohnal1, M. Hackl2, J. Hainfellner3, R. Reitermeier4, T. Felzmann4, C. Visus4;
1
CCRI St. Anna Childrens’ Cancer Research Institute, Vienna, Austria, 2TAmiRNA GmbH, Vienna, Austria, 3Institute of Neurology, Medical University of Vienna, Vienna, Austria, 4Activartis Biotech GmbH,
Vienna, Austria.
P.D.06.05 Early DC and NK cell activation during the anticancer therapeutic response induced by TNFa tumor vessel delivery and melphalan
E. Balza1, S. Zanellato2,3, A. Poggi4, D. M. Noonan2,5, A. Rubartelli1, L. Mortara2;
1
Laboratory of Cell Biology, Department of Translational Oncology, IRCSS AOU San Martino-IST, Genova, Italy, 2Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy,
3
Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy, 4Unit of Molecular Oncology and Angiogenesis, IRCCS AOU San Martino-IST, Genova, Italy, 5Science and
Technology Center, IRCCS MultiMedica, Milano, Italy.
P.D.06.06 Effect of TRIMEL’s fractions on clinically effective Dendritic Cells against melanoma
F. Falcón-Beas1,2,3, J. Gatica1,2,3, I. Flores1,2,3, N. Meza1,2,3, C. Falcón-Beas1,2,3, P. Cabané4, F. Salazar-Onfray1,2,3, M. N. López1,2,3;
Faculty of Medicine, University of Chile, Santiago, Chile, 2Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile, 3Millennium Institute on Immunology and
Immunotherapy, Universidad de Chile, Santiago, Chile, 4Clinical Hospital, University of Chile, Santiago, Chile.
1
P.D.06.07 Allogeneic activated NK cells from healthy donors are effective against chemoresistant bladder cancer stem cells
M. Ferreira-Teixeira1,2, D. Paiva-Oliveira1,2, B. Parada1,3, F. Reis1,2, C. Gomes1,2,4, P. Rodrigues-Santos2,5;
1
Pharmacology and Experimental Therapeutics, IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Portugal, 2CNC.IBILI - University of Coimbra, Portugal, Coimbra, Portugal, 3Urology and Renal
Transplantation Department - Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal, 4Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University
of Coimbra, Coimbra, Portugal, 5Institute of Immunology - Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
P.D.06.08 Boosting the immunogenicity of an oncolytic vaccinia virus to enhance anti-tumor immunity
M. Hirvinen1, C. Capasso1, K. Guse2, M. Garofalo1, A. Vitale1, M. Ahonen2, L. Kuryk1, M. Vähä-Koskela3, A. Hemminki2, D. Greco4, V. Cerullo1;
1
Laboratory of ImmunoViroTherapy, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland, 2Cancer Gene Therapy Group, Department of Pathology and
Transplantation laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland, 3Institute of Biotechnology, University of Helsinki, Helsinki, Finland, 4Finnish Institute of Occupational Health,
Helsinki, Finland.
P.D.06.09 Heat Shock Conditionated Ovarian carcinoma cell lines lysate induces maturation and proinflamatory response on human Dendritic Cells
J. Gatica1,2,3, F. Falcón-Beas1,2,3, I. Flores1,2,3, C. Falcón-Beas1,2,3, A. Gleisner1,2,3, F. Salazar-Onfray1,2,3, M. N. López1,2,3;
Faculty of Medicine, University of Chile, Santiago, Chile, 2Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile, 3Millennium Institute on Immunology and
Immunotherapy, Universidad de Chile, Santiago, Chile.
1
P.D.06.11 Vaccine-induced but not tumor-derived interleukin-10 dictates the efficacy of interleukin-10 blockade in therapeutic vaccination
D. Llopiz1,2, F. Aranda1, N. Díaz-Valdés1, M. Ruiz1,2, S. Infante1, V. Belsúe1, J. Lasarte1,2, P. Sarobe1,2;
1
Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain, 2IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
P.D.06.12 Harnessing the phagocytic potential of tumor-associated macrophages using a novel bispecific antibody targeting CD19/CD47 to effectively promote treatment of
B cell malignancies
V. Buatois, X. Chauchet, A. Papaioannou, L. Cons, L. Chatel, V. Moine, L. Broyer, N. Fischer, K. Masternak, M. Kosco-Vilbois, W. Ferlin, Z. Johnson;
Novimmune S.A., Geneva, Switzerland.
P.D.06.13
Preclinical activity of dasatinib in mantle cell lymphoma
A. Marcos Jiménez, A. De Rosendo Serrano, I. Portero Sainz, B. Colom-Fernández, F. Herrera, C. Muñoz Calleja;
Instituto de Investigación Sanitaria Princesa, Servicio de Inmunología, Hospital Universitario La Princesa, Madrid, Spain.
P.D.06.14 Delivery of dietary compound regulates MCP-1 in murine prostate cancer cells
M. K. Mishra1, J. Stokes III1, U. Singh2, E. Nyairo1, D. Dean1;
1
Alabama State University, Montgomery, AL, United States, 2University of South Carolina, Columbia, AL, United States.
P.D.06.15 Sorafenib, nilotinib and dasatinib, but not sunitinib, decrease MDSC frequencies and function in vitro
A. Heine1, J. Schilling2, C. Llanto3, C. Kurts3, P. Brossart1, P. A. Knolle4, B. Höchst4;
1
Medical Clinic for Oncology, Bonn, Germany, 2Institute of molecular medicine, Bonn, Germany, 3Institute of experimental immunology, Bonn, Germany, 4Institute of molecular immunology, München,
Germany.
40
P.D.06.16 Ipilimumab reshapes T cell memory subsets in melanoma patients with clinical response
J. Felix1, J. Lambert2, C. Pages3, H. Guermouche1, I. Sidina3, R. Porcher2, D. Jorge Cordeiro1, G. Maki1, M. Viguier3, E. Maubec4, A. Toubert1, C. Lebbé3, H. Moins-Teisserenc1;
1
INSERM U1160, Hôpital de Saint-Louis, Paris, France, 2Laboratoire de Biostatistiques, Hôpital de Saint-Louis, Paris, France, 3Service de Dermatologie, Hôpital de Saint-Louis, Paris, France, 4Service de
Dermatologie, Hôpital Bichat, Paris, France.
Immunotherapy of Merkel Cell Carcinoma by DC vaccination against the large T antigen of the Merkel Cell Polyomavirus
K. F. Gerer1,2, G. Schuler1, N. Schaft1, J. Dörrie1, S. Hoyer1;
1
Universitätsklinikum Erlangen, Department of Dermatology, Erlangen, Germany, 2Friedrich-Alexander Universität Erlangen-Nürnberg, Department of Genetics, Erlangen, Germany.
P.D.06.18 Inhibiting the IFNAR receptor increases antitumor potency of mRNA vaccines
A. De Beuckelaer1, C. Pollard1,2, S. De Koker1, J. Grooten1;
1
Ghent University, Ghent, Belgium, 2Institute of Tropical Medicine, Antwerp, Belgium.
P.D.06.19 Overcoming multidrug resistance with inhibitor of ABC transporters bound to HPMA copolymer carrier as a potential therapeutic approach for treatment of
chemoresistant cancer
L. Sivak1, V. Subr2, K. Ulbrich2, M. Kovar1, B. Rihova1;
1
Institute of Microbiology of the ASCR, v. v. i., Prague, Czech Republic, 2Institute of Macromolecular Chemistry of the ASCR, v. v. i., Prague, Czech Republic.
Monday
P.D.06.17
P.D.06.20 The Efficient Generation of Immunocompetent Dendritic Cells from Leukemic Blasts in Acute Myeloid Leukemia: A Local Experience
K. Bagheri1, A. A. pourfathollah1, K. Alimoghadam2, Z. M. Hassan1, J. Hdjati3, S. Moazzeni1;
1
Tarbiat Modares University, Tehran, Iran, Islamic Republic of, 2Hematology, Oncology and Bone Marrow Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran,
Iran, Islamic Republic of, 3Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
P.D.06.21 A novel therapy for melanoma developed in mice: transformation of melanoma into dendritic cells with Listeria monocytogenes
C. Alvarez-Dominguez1, R. calderon-gonzalez1, L. Bronchalo-Vicente1,2, J. Freire3, L. Alaez-Alvarez1, J. Gomez-Roman3, S. Yañez-Diaz2;
1
Instituto de Formacion e Investigación Marques de Valdecilla, Santander, Spain, 2Servicio de Dermatologia. Hospital Universitario Marques de Valdecilla, Santander, Spain, 3Servicio de Anatomia
Patologica. Hospital Universitario Marques de Valdecilla, Santander, Spain.
P.D.06.22 Tumor localization matters: pre-clinical evaluation of mRNA-based immunotherapy against cervical cancer
L. Bialkowski1, A. van Weijnen1, K. Van der Jeught1, D. Renmans1, G. Stangé2, K. Breckpot1, C. Heirman1, J. L. Aerts1, K. Thielemans1;
Laboratory of Molecular and Cellular Therapy, Vrije Universiteit Brussel, Brussels, Belgium, 2Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium.
1
P.D.06.23
Reversible NTAmer allow improved analysis and sorting of antigen-specific CD8+ T cells
P. Guillaume1, A. Kennel1, J. Schmidt1, M. Hebeisen2, N. Rufer2, I. Luescher3;
1
TC Metrix Ltd, Epalinges, Switzerland, 2Department of Oncology, University Hospital center, Lausanne, Switzerland, 3Ludwig Center of the University of Lausanne, Epalinges, Switzerland.
Chairpersons: Catarina R. Almeida; Porto, Portugal / Marina Garin; Madrid, Spain
P.D.07.01
Hypoxia Promotes Differentiation Potential of Canine Adipose Tissue-Derived Mesenchymal Stem Cells
P.D.07.02
The role of mesenchymal stem cell-derived matrix metalloproteinase 9 (MMP-9) in immunomodulation
P.D.07.03
Adiponectin isoforms and leptin impact on rheumatoid infrapatellar fad pad-derived mesenchymal stem cells function
J. Lee, J. Byeon, N. Gu, H. Kim, G. Lee, S. Cha;
T. Y. Feng, B. L. Chiang;
The Graduate Institute of Immunology, National Taiwan University, College of Medicine, Taipei City, Taiwan.
U. Skalska, E. Kontny;
Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland.
P.D.07.04 Immunomodulatory effects of MSC on T cell reconstitution following HSC transplantation in lymphoma patients
E. Shevela, E. Batorov, N. Pronkina, I. Kryuchkova, A. Ostanin, E. Chernykh;
Institute of Fundamental and Clinical Immunology, Novosibirsk, Russian Federation.
P.D.07.07
Phagocytic activity of peritoneal macrophages under the influence of allogenic stem cells
O. Dzhus1, L. Kladnytska2, A. Mazurkevych2, D. Shelest1, G. Svitina1, L. Garmanchuk1, S. Velychko2, V. Kovpak2;
1
Educational and Scientific Centre «Institute of Biology» of Taras Shevchenko National University of, Kyiv, Ukraine, 2National University of Life and Environmental Sciences of Ukraine, Kyiv, Ukraine.
P.D.07.08 The incidence of CD34+ hematopoietic stem cells in Georgian newborns
N. Nanava, N. Kukuladze, I. Pantsulaia, N. Kikodze, T. Chikovani;
Tbilisi State Medical University, Tbilisi, Georgia.
P.D.07.09 Lymphotoxin-beta receptor signalling regulates self-renewal during stress induced hematopoiesis
S. Hoepner1, D. Korner1, C. Riether1, A. Ochsenbein1,2;
1
Tumor-Immunology,Department Clinical Research, University of Bern, Bern, Switzerland, 2Institute for Medical Oncology, Inselspital, University Hospital Bern, Bern, Switzerland.
P.D.07.10
Engineered Smooth Muscle from Human Adipose Derived Stem Cells for Vascular Dysfunction Repair in Systemic Sclerosis
P.D.07.11
In vitro generation of HCMV specific T-lymphocytes
P.D.07.12
The Impact Of Intraartricular PRP Therapy In Gonarthrosis
P.D.07.13
Dickkopf-3 is essential for tumor-associated mesenchymal stem cells to regulate anti-tumor immune responses
N. Hammam1, H. Orabi2,1, T. F Lue2;
1
Faculty of Medicine, Assiut University, Assiut, Egypt, 2Knuppe Molecular Laboratory, School of Medicine, University of California, San Francisco, CA, United States.
J. Mackova, K. Zurkova, V. Sroller, L. Piskova, J. Musil, K. Babiarova, S. Nemeckova;
Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic.
M. Bicer, N. Isiksacan, E. Ercin, H. Cumen, A. Kural, C. Kural;
Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
K. Lu1,2, A. Tounsi1, N. Shridhar3, G. Küblbeck1, A. Klevenz1, S. Prokosch1, T. Bald3, T. Tüting3, B. Arnold1;
German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Netherlands Cancer Institutee, Amsterdam, Netherlands, 3Laboratory of Experimental Dermatology, Department of Dermatology and
Allergy, University of Bonn, Bonn, Germany.
1
P.D.07.14
Hematopoietic Stem Cells have distinct responses to acute and chronic bacterial infection
J. L. Dunn1,2,3, F. Tzelepis1,2,3, M. Verway1,2,3, A. Nyznck1,4, M. Divangahi1,2,5;
1
McGill University, Montreal, QC, Canada, 2McGill International TB Centre, Montreal, QC, Canada, 3Meakins-Christie Laboratories, Montreal, QC, Canada, 4Complex Traits Group, Montreal, QC, Canada,
5
Meakins-Christie, Montreal, QC, Canada.
P.D.08 Biomarkers of Human Immune Responses & Immunogenicity against Biopharmaceuticals - Part 1
Chairpersons: Gerhard Zlabinger; Vienna, Austria / Gabriella Sarmay; Budapest, Hungary
P.D.08.01 Circulating miRNA in critical inflammatory conditions
S. Caserta, F. Kern, J. Cohen, S. Drage, S. Newbury, M. Llewelyn;
University of Sussex -Brighton and Sussex Medical School, Falmer, Brighton, United Kingdom.
P.D.08.02 Role of cytokines in preterm birth
V. Tyagi, T. Sharma, B. D. Banerjee, R. S. Ahmed, A. K. Tripathi, K. Guleria;
University College of medical sciences and GTB Hospital (University of Delhi), Delhi, India.
P.D.08.03 An optimized ELISpot assay to determine CMV protein-reactive cells of cell-mediated immunity
S. Barabas, T. Spindler, C. Tonar, T. Widmann, H. Bendfeldt, K. Böckl, L. Deml;
Lophius Biosciences GmbH, Regensburg, Germany.
41
P.D.08.04 Impact of storage time, temperature and anticoagulants on extracellular vesicles distribution in whole blood
C. Lamm1, J. Hartmann1, F. Preißing1, L. Hell2, C. Ay2, K. Dragosits1, A. Bee3, L. Wisgrill4, A. Spittler1,5;
1
Medical University of Vienna, Department of Surgery, Research Laboratories, Vienna, Austria, 2Medical University of Vienna, Department of Internal Medicine I, Vienna, Austria, 3University Clinic St. Pölten,
St. Pölten, Austria, 4Medical University of Vienna, Department of Pediatrics & Adolescent Medicine, Vienna, Austria, 5Medical University of Vienna, Core Facility Flow Cytometry, Vienna, Austria.
P.D.08.05 Danger signal-dependent activation of human dendritic cells by plasma-derived factor VIII products
Monday
L. Miller, S. Weissmüller, E. Ringler, Junior Research Group “Novel Vaccination Strategies and Early Immune Responses”, P. Crauwels, G. van Zandbergen, Division of Immunology, R. Seitz, Division of
Haematology/Transfusion Medicine, Z. Waibler, Junior Research Group “Novel Vaccination Strategies and Early Immune Responses”;
Paul-Ehrlich-Institut, Langen, Germany.
P.D.08.06 In vitro Homing Routes to evaluate migration characteristics of CD4+ cells of healthy and GVHD mice
V. C. Hirschfeld-Warneken1,2, M. Danner1,2, J. P. Spatz1,2;
1
Max Planck Institute for Intelligent Systems, Department New Materials and Biosystems, Stuttgart, Germany, 2Institute for Physical Chemistry, Department Biophysical Chemistry, University of
Heidelberg, Germany.
P.D.08.08 Subpopulations of neutrophilic granulocytes CD16brightCD11bbright and CD16dimCD11bbright: new differential biomarkers in diagnostics of acute viral and
acute bacterial infections
I. V. Nesterova1, N. V. Kolesnikova2, G. A. Chudilova2, L. V. Lomtatidze2, S. V. Kovaleva2;
1
The Russian People’s Friendship University, Moscow, Russian Federation, 2Kuban State Medical University, Krasnodar, Russian Federation.
P.D.08.09 Interferon g level from lymphocytes cell culture that induced with ESAT-6 as a diagnostic marker for Latent TB Infection (LTBI)
D. F. Leona1, A. E. Putra1, T. Faadhila1, H. Milfiadi1, O. Khairsyaf1, Y. Widjajanti2, N. Rintiswati2;
1
Andalas University, Padang, Indonesia, 2Gadjah Mada University, Yogyakarta, Indonesia.
P.D.08.10 Milieu Interieur - defining the boundaries of a healthy immune response through standardized immunophenotyping
D. Duffy1,2, A. Urrutia1,2, C. Posseme1, R. Djebali1, V. Rouilly1, M. Hasan1, S. Thomas1,2, V. Libri1, E. Patin1,3, L. Rogge1, M. Fontes1, L. Quintana-Murci1,3, M. L. Albert1,2, &. The Milieu Intérieur Consortium1;
1
Institut Pasteur, Paris, France, 2Inserm U818, Paris, France, 3CNRS URA3012, Paris, France.
P.D.08.11 Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in treated individuals with HIV-1 infection: a
case control study
D. D. Murray1, K. Suzuki1, M. Law1, J. Trebicka2, J. Neuhaus3, D. Wentworth3, M. Johnson4, M. J. Vjecha5, A. D. Kelleher1, S. Emery1, INSIGHT Study Group;
1
Kirby Institute for Infection and Immunity in Society, Sydney, Australia, 2Department of Internal Medicine, University of Bonn, Bonn, Germany, 3University of Minnesota, Minneapolis, MN, United States,
4
Ian Charleson Day Centre, Royal Free Hampstead NHS Trust, London, United Kingdom, 5Institute for Clinical Research, Veterans Affairs Medical Centre, Washington D.C., DC, United States.
P.D.08.12 Patient-specific immunological imprint: dissecting tissue complexity to clinical relevance
A. Meshcheryakova1, E. Bajna1, M. Svoboda1, G. Heinze2, P. Birner3, D. Mechtcheriakova1;
1
Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna, Austria, 2Center for Medical Statistics, Informatics, and
Intelligent Systems, Medical University of Vienna, Vienna, Austria, 3Department of Pathology, Medical University of Vienna, Vienna, Austria.
P.D.08.13
Detection of defensin alpha1 in the urine of leptospirosis patients with kidney injury
H. Chagan-Yasutan1,2, Y. Chen2, P. Leano3, H. Iwasaki1, F. Hanan2, D. Taurustiati2, Y. Ashino2,1, F. Telan3, T. Hattori1,2;
1
Disaster-related Infectious Disease, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan, 2Emerging Infectious Diseases, Graduate School of Medicine, Tohoku University,
Sendai, Japan, 3SACCL, San Lazaro Hospital, Manila, Philippines.
P.D.08.15 Lymphocytes are low in severe sepsis
J. Jämsä1, V. Huotari2, E. Savolainen2, H. Syrjälä3, T. Ala-Kokko1;
1
Department of Anaesthesiology, Division of Intensive Care Medicine, Oulu University Hospital, Medical Research Center Oulu, University of Oulu, Oulu, Finland, 2Nordlab Oulu, Oulu University Hospital,
Medical Research Center Oulu, Oulu, Finland, 3Department of Infection Control, Oulu University Hospital, Medical Research Center Oulu, Oulu, Finland.
P.D.08.16 Serum IgG1 antibodies against phase-dependent Mycobacterium tuberculosis antigens are increased in active tuberculosis and after initiation of anti-TB
chemotherapy
A. M. Mattos1, A. S. Chaves1, B. B. Figueiredo1, K. Franken2, A. Ferreira1, T. H. Ottenhoff2, H. C. Teixeira1;
1
Federal University of Juiz de Fora (UFJF) - Department of Parasitology, Microbiology and Immunology - ICB, Juiz de Fora, Brazil, 2Leiden University Medical Centre - Department of Infectious Diseases,
Leiden, Netherlands.
P.D.08.17
Barcoding of live PBMC for multiplexed mass cytometry analyses
H. E. Mei, M. D. Leipold, A. R. Schulz, C. Chester, H. T. Maecker;
Stanford University, Stanford, CA, United States.
Chairpersons: Niklas Beyersdorf; Wuerzburg, Germany / Antoine Toubert; Paris, France
P.D.09.01 Linking CD8+ T cell homing biomarkers to distinct organ manifestations of acute graft versus host disease (aGVHD)
N. Lupsa1,2, B. Ersek1,2, A. Bencsik1,2, E. Sarzsinszky1,2, A. Horvath1,2, P. Remenyi3, J. Matko4, T. Masszi3, E. Buzas1, Z. Pos1,2;
1
Semmelweis University, Dept. of Genetics, Cell and Immunbiology, Budapest, Hungary, 2Hungarian Academy of Sciences - Semmelweis University ”Lendület” Experimental and Translational Immunomics
Research Group, Budapest, Hungary, 3St. Istvan and St. Laszlo Hospital, Dept. of Hematology and Stem Cell Transplantation, Budapest, Hungary, 4Eötvös Loránd University, Dept. of Immunology,
Budapest, Hungary.
P.D.09.02 Inducible CD28 deletion on donor T cells in a mouse model of acute graft versus host disease
A. Uri, S. Werner, T. Hünig, T. Kerkau, N. Beyersdorf;
Institut for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
P.D.09.03 Plasma levels of Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein 3 following chemotherapy and allogeneic hematopoietic stem cell
transplantation
S. Weischendorff1,2, K. Kielsen1,2, H. Sengeløv3, L. P. Ryder4, A. Juul5, K. G. Müller1,2;
1
Institute for Inflammation Research, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark, 2Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital
Rigshospitalet, Copenhagen, Denmark, 3Department of Hematology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark, 4Department of Clinical Immunology, Copenhagen University
Hospital Rigshospitalet, Copenhagen, Denmark, 5Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
P.D.09.04 The serine protease aPC regulates T-cell activation and GvHD via the protease activated receptor PAR-3
S. Ranjan1, B. Giriyapura1, T. Madhusudhan1, K. Shahzad1, D. Reinhold2, B. Schraven2, T. Fischer3, T. Luft4, F. Heidel3, B. Isermann1;
1
Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke-University, Magdeburg, Germany, 2Institute for Molecular and Clinical Immunology, Otto-von-Guericke-University, Magdeburg,
Germany, 3Department of Hematology and Oncology, Center of Internal Medicine, , Otto-von-Guericke-University, Magdeburg, Germany, 4Department of Medicine V, University of Heidelberg, Heidelberg,
Germany.
P.D.09.05 Association of CD19+CD21low B-cells with active chronic graft-versus-host-disease: A validation study in two independent patient cohorts
Z. Kuzmina1, M. Kralj2, R. Weigl2, J. Rose3, S. Z. Pavletic4, A. Rottal5, U. Koermoeczi5, W. Pickl6, F. T. Hakim3, H. T. Greinix7;
1
Hietzing Hospital, Fifth Department of Internal Medicine – Oncology/Hematology, Vienna, Austria, 2Internal Medicine I department, Medical University of Vienna, Vienna, Austria, 3Preclinical Service
Experimental Transplantation & Immunology Branch, NCI, NIH, Bethesda, MD, United States, 4Center for Cancer Research Experimental Transplantation and Immunology Branch , Graft-versus-Host
and Autoimmunity Unit, National Cancer Institute, NIH, Bethesda, MD, United States, 5Institute of Immunology, Medical University of Vienna, Vienna, Austria, 6Division of Cellular Immunology &
Immunohematology Institute of Immunology Center for Pathophysiology, Infectiology & Immunology, Vienna, Austria, 7Hematology department, Graz, Austria.
P.D.09.06 CD19+CD21low B-cells as biomarkers for prediction and monitoring of response in chronic graft-versus-host disease
M. Kralj1, R. Weigl1, Z. Kuzmina1, A. Rottal1, U. Koermoeczi1, W. Pickl1, H. T. Greinix2;
1
Medical University of Vienna, Vienna, Austria, 2Medical University of Graz, Graz, Austria.
P.D.09.07 Detectable functional CMV T-cells predicts end of CMV reactivation post HSCT, virus control fails with glucocorticoids
O. Pelak, L. Krol, P. Hubacek, P. Keslova, R. Formankova, P. Sedlacek, O. Hrusak, T. Kalina;
Department of Paediatric Hematology/Oncology, 2nd Medical School, Charles University Prague, Prague, Czech Republic.
P.D.09.08 Deletion of Blimp-1 in Donor T Cells Significantly Attenuates Mouse Graft-versus-host Disease
K. Xu, C. Chen;
P.D.09.09 Graft-versus-host disease after syngeneic allogeneic stem cell transplantation - A case report
J. Eguía-Núñez1, J. L. Monserrat-Coll2, E. Martínez-Barba3, M. Muro-Amador1, J. A. Campillo-Marquina1, A. M. García-Alonso1, J. M. Moraleda-Jiménez2;
1
Immunology Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, 2Hematology Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, 3Pathology
Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
42
P.D.09.11 Cdc42 inhibitor ML141 enhances G-CSF-induced hematopoietic stem and progenitor cell mobilization
K. Xu, C. Chen, X. Song;
P.D.09.12 Validation and implementation of next generation sequencing technology for HLA typing in our laboratory routine
P.D.09.13
KIR B-content score 2 in donors reduces risk of relapse and improve survival after allogeneic hematopoietic stem cell transplant
J. Jimenez1, W. G. Vazquez1, J. C. Martinez2, M. A. Arrazola2, M. M. Contreras3, M. L. Gonzalez3, M. E. Perez1;
Immunology Research Department, Pediatric Hospital, CMN SXXI, IMSS, Mexico City, Mexico, 2Blood Bank, Specialty Hospital, CMN SXXI, IMSS, Mexico City, Mexico, 3Hematopoietic Cell Transplantation,
Specialty Hospital, CMN S XXI, IMSS, Mexico City, Mexico.
1
P.D.09.14 A simple and practical method for increasing of proliferation the mesenchymal stem cells in mouse
A. Aghebati Maleki, L. Aghebati Maleki;
Immunology, Tabriz, Iran, Islamic Republic of.
Monday
F. Rudilla, F. Vidal, M. Herrero, E. Palou, I. Corrales, N. Borràs, E. Campos, J. Caro, C. Ambros, L. Mongay, J. Caro;
Banc de Sang i Teixits de Barcelona, Barcelona, Spain.
P.D.10 Immunomodulation by Nutrients & Vitamines
Chairpersons: Roman Khanferyan; Moscow, Russian Federation / Ralf A. Linker; Erlangen, Germany
P.D.10.01
Oral administration of baicalein attenuates food allergy symptoms by inducing regulatory T cells in a mouse model
P.D.10.02
In vitro and in vivo immunomodulating activity of red seaweed - Eucheuma denticulatum obtained from Sabah, Malaysia
P.D.10.03
Vaccination with MOG plus vitamin D is tolerogenic and prevents experimental autoimmune encephalomyelitis
D. Shon, H. S. Shin;
Korea Food Research Institute, Seongnam-si, Korea, Republic of.
S. Y. Pan, B. E. Cheong, P. Matanjun, P. L. Teoh, T. Y. Lau, P. C. Lee;
University Malaysia Sabah, Kota Kinabalu, Malaysia.
L. A. Mimura1, F. Chiuso-Minicucci1, T. C. Fraga-Silva1, S. G. Zorzella-Pezavento1, T. D. França1, L. W. Ishikawa1, M. Penitenti2, M. V. Ikoma2, A. Sartori1;
1
São Paulo State University, Botucatu, Brazil, 2Dr. Amaral Carvalho Foundation, Jaú, Brazil.
P.D.10.04 Efficacy of tolerogenic vaccination with MOG/VitD in EAE is not disrupted by Candida albicans infection
T. C. Fraga-Silva, L. N. Mimura, S. G. Zorzella-Pezavento, T. D. França, L. W. Ishikawa, A. Sartori;
São Paulo State University (UNESP), Botucatu, Brazil.
P.D.10.05
Epicutaneous therapy with MOG and vitamin D analogue association blocks EAE development
S. G. Zorzella-Pezavento, L. N. Mimura, T. C. Fraga-Silva, T. D. França, L. W. Ishikawa, A. Sartori;
São Paulo State University (UNESP), Botucatu, Brazil.
P.D.10.06 Germ free mice during 7 day conventionalization: an initial study
J. Krizan;
Institute of Microbiology of the ASCR, v. v. i., Prague, Czech Republic.
P.D.10.07
Immunomodulatory effects of L-glutamic acid and L-cysteine on T- and B-cell immunity
N. Salyha, R. Iskra;
Institute of Animal Biology, Lviv, Ukraine.
P.D.10.08 Mechanisms of influence of licorice root flavonoids on apoptosis of tumor cells in vitro
M. D. Tsitsuashvili, D. Z. Albegova;
The Russian National Research Medical University named after N.I. Pirogov, Moscow, Russian Federation.
P.D.10.09 Study the role of Mitogen-Activated Protein Kinases activation in proliferation and apoptosis processes of the pharyngeal tumour cells
M. Bostan, G. Matei, C. Hotnog, M. Mihaila, V. Roman, L. I. Brasoveanu;
Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
P.D.10.12
Dietary fatty acids directly impact CNS autoimmunity via the small intestine
P.D.10.13
Assessment of Effects of Micronutrient Supplementation on Products of Macrophage Activation during Treatment of Pulmonary Tuberculosis Patients
P.D.10.14
Resveratrol increases cd68+ kupffer cells co-localized with adipose differentiation-related protein (adfp) and ameliorates high-fat-diet-induced fatty liver in mice
P.D.10.15
Do Quinton® solutions exert any modulation on the immune system?
S. Jörg1, A. Haghikia2, A. Hammer1, D. A. Akkad2, D. N. Müller3, R. Gold2, R. A. Linker1;
1
University Hospital Erlangen, Erlangen, Germany, 2Ruhr-University Bochum, Bochum, Germany, 3Experimental and Clinical Research Center & Max-Delbrück Center Berlin, Berlin, Germany.
M. O. Akiibinu1, T. J. Oyewumi2;
1
Caleb University Lagos, Lagos, Nigeria, 2Immunology Unit, Department of Chemical Pathology, College of Medicine, University of Ibadan,, Ibadan,, Nigeria.
K. Nishikawa1, K. Iwaya2, M. Kinoshita2, Y. Fujiwara3, S. Thiruppathi4, T. Suzuki4, S. Hiroi2, S. Seki2, T. Sakamoto2;
1
Chuo university, Tokyo, Japan, 2National Defense Medical College, Saitama, Japan, 3Ochanomizu University, Tokyo, Japan, 4National Institute of Health Sciences, Tokyo, Japan.
S. Pascual-García, P. Martínez-Peinado, M. de la Sen, F. Marco de la Calle, M. García-Irles, Y. Segovia-Huertas, J. Sempere-Ortells;
University of Alicante, Alicante, Spain.
P.D.10.16 Affinities for 25(OH)D3/D2 of the three main genetic isoforms of human vitamin D binding proteins (VDBP)
P. Kiszel1,2, S. Pohl1, M. Biehl1, L. von Proff1, T. Meier1, A. Engel1, M. Schraeml1;
1
Roche Diagnostics, Penzberg, Germany, 2German Academic Exchange Service (DAAD), Bonn, Germany.
P.D.10.17
The capacity of major cows milk allergen Bos d 5 suppressing T-cell responses upon binding of the active vitamin A metabolite retinoic acid
K. Hufnagl1, S. Wagner1, L. F. Pacios2, F. Roth-Walter1, R. Bianchini1, E. Jensen-Jarolim1,3;
1
Comparative Medicine, Messerli Research Institute of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria, 2Biotechnology Department, Center for Plant
Biotechnology and Genomics, Technical University of Madrid, Madrid, Spain, 3Comparative Immunology and Oncology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology,
Infectiology and Immunology, Medical University Vienna, Vienna, Austria.
P.D.10.18 Riboflavin deficiency increases the proinflammatory activation of fat cells - in vitro study
A. I. Mazur-Bialy1, J. Homa2, E. Pochec2;
1
Faculty of Health Science, Jagiellonian University Medical College, Krakow, Poland, 2Jagiellonian University, Krakow, Poland.
Track E – Other
P.E.01 Structural Biology & Imaging of the Immune System
Chairpersons: Johannes Huppa; Vienna, Austria / Walter Keller; Graz, Austria
P.E.01.01
Human milk IgG and sIgA Fab-arms exchange, promoted by the specific factor
P.E.01.02
Examination of coexistance and connection of antinuclear antibody (ANA) with the positivity of thyroid autoantibodies
P.E.01.03
Expression and solution of the three-dimensional structure of the wheat allergen beta amylase
S. Sedykh1,2, V. Prints2, V. Buneva1,2, G. Nevinsky1,2;
1
SB RAS ICBFM, Novosibirsk, Russian Federation, 2Novosibirsk State University, Novosibirsk, Russian Federation.
R. Kesli, Ö. Cetinkaya, G. Asık, C. Demir;
Afyon Kocatepe University, Afyonkarahisar, Turkey.
G. Hofer1, S. Pahr2, R. Valenta2, W. Keller1;
1
Institute of Molecular Biosciences, University of Graz, Graz, Austria, 2Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and
Immunology, Medical University of Vienna, Vienna, Austria.
43
Monday
P.E.01.04
Recombinantly produced insect Thaumatin-like protein (Sgre1) and its role as putative allergen
P.E.01.05
Establishment of keratinocyte cell lines from human hair follicles
P.E.01.06
Structural Recognition of CD1d-restricted Microbial lipid antigen by Type II Natural killer T cells
P.E.01.07
New fluorogenic dyes for analysis of cellular processes by flow cytometry and confocal microscopy
P.E.01.08
Incorporation of BD Horizon BV421 and BD Horizon BV480 immunofluorescence reagents improves immunofluorescence microscopy
P.E.01.09
The percentages of endothelial progenitor cell with expression of CD133+, CD309+, CD34+ at 6. hour after both artery laceration and 20 years tooth extraction
procedure in peripheral blood samples
M. Eder, W. Keller;
Institute of Molecular Biosciences, University of Graz, Graz, Austria.
T. Berger1, M. Gschwandtner1, A. Starjeriu2, A. Elbe-Bürger1, J. Grillari2, R. Grillari-Voglauer2, E. Tschachler1, M. Mildner1;
1
Medical University of Vienna, Department of Dermatology, Wien, Austria, 2University of Natural Resources and Life Sciences, Wien, Austria.
S. Sundararaj;
Monash University, Clayton, Australia.
I. Balabanov1, A. Kurutos2, K. Nikolova1, N. Mihaylova1, S. Stoitsova3, T. Deligeorgiev2, A. Tchorbanov1;
1
Laboratory of Experimental Immunology, Department of Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria, 2Department of Applied Organic Chemistry, Faculty
of Chemistry and Pharmacy, Sofia University, Sofia, Bulgaria, 3Department of Morphology of microorganisms and electron microscopy, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia,
Bulgaria.
J. Rohrer, A. Wright, J. Martin, Y. Marrari;
BD Biosciences, La Jolla, CA, United States.
B. Saraymen1, I. Karaman2, Z. B. Gönen3, F. Doğruel3, M. Y. Köker1;
1
Department of Immunology, Erciyes University Medical Faculty, Kayseri, Turkey, 2Department of Orthopaedics and Traumatology, Erciyes University Medical Faculty, Kayseri, Turkey, 3Department of Oral
and Maxillofacial Surgery, Erciyes University Dentistry Faculty, Kayseri, Turkey.
44
P.E.01.10
Whole-cell MALDI-TOF mass spectrometry as a rapid method for leukocyte subtyping
P.E.01.11
Visualization of Mechanical Forces within the Immunological Synapse
P.E.01.12
Maturation of synaptobrevin2-containing lytic granules (LGs) following endocytosis in primary mouse cytotoxic T lymphocytes (CTLs)
P.E.01.13
Platelet rich plasma reduced vascular endothelial growth factor receptor-2 (VEGFR2) levels in human vascular endothelial cell culture
P.E.01.14
Mechanical Forces in T-Cell Antigen Recognition
P.E.01.15
Imaging in cancer immunology: Phenotyping of multiple immune cell subsets in-situ in FFPE tissue sections
P.E.01.16
Optimism affect the immune response
K. Strasser1, E. Zareva2, M. Holzlechner2, H. Birnleitner1, M. Marchetti-Deschmann2, M. Bergmann1, R. Oehler1;
1
Medical University of Vienna, Vienna, Austria, 2Vienna University of Technology, Vienna, Austria.
J. Göhring1, F. Kellner2, G. Schütz1, J. Huppa2;
1
Institute of Applied Physics, Wien, Austria, 2Institute for Hygiene and Applied Immunology, Wien, Austria.
H. Bzeih;
University of Saarland, Geb 59, Homburg, Germany.
M. Shahidi1,2, P. Hayat3;
1
Cellular & Molecular Research Center (CMRC), Tehran, Iran, Islamic Republic of, 2Hematology department, school of Allied Medicine, Iran University of Medical sciences, Tehran, Iran, Islamic Republic of,
3
Cellular & Molecular Research Center (CMRC), Iran University of Medical Science, Tehran, Iran, Islamic Republic of.
F. Kellner1, J. Göhring1,2, L. Schrangl2, R. Platzer1, G. J. Schütz2, J. B. Huppa1;
1
J. R. Mansfield1, B. Wendik2, C. C. Hoyt1, E. Stack1, M. Feldman3, C. Bifulco4, B. Fox4;
1
PerkinElmer, Hopkinton, MA, United States, 2PerkinElmer, Rodgau, Germany, 3University of Pennsylvania, Philadelphia, PA, United States, 4Providence Cancer Center, Portland, OR, United States.
K. Curzytek, M. Kubera, R. Rygula, J. Kregiel, W. Duda, E. Trojan, W. Lason;
Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
TUESDAY
Tuesday
Tuesday, September 8, 2015
SEPTEMBER 8, 2015
45
Tuesday
P.A.11 Lymphocyte Development - Part 1
P.C.09 Innate Immunity - Inflammation - Part 1
P.A.12 Antigen Receptor Signalling
P.C.11 Macrophages - Part 1
P.C.15 Cytokines - Part 1
P.A.19 Antibody Engineering and B Cell Effector Molecules
P.B.15 Immunity to Virus Infection - Part 1
P.B.16 Immunity to Bacterial Infection and Parasites
P.B.17 Immunity to Parasite Infection
P.B.20 Inflammatory Bowel Disease
P.D.16 Immunotherapy for Infectious Diseases
P.B.21 Neuroimmunology and Multiple Sclerosis
P.B.22 (Chronic) Inflammatory Joint Disease - Part 2
P.B.23 Animal Models of Autoimmunity
P.D.18 Immunopharmacology
P.B.24 Mediators of (Neuro) Immune Regulation
P.B.25 Allergen Specific Immune Response - Part 2
46
Track E – Other
P.E.02 Immune Response in Aging & Systems Biology - Part 1
P.B.28 Tumormarkers
P.E.03 Metabolism & Immunity
Chairpersons: Francesca Di Rosa; Roma, Italy / Pablo Engel; Barcelona, Spain
P.A.11.01
Down-regulation of autoreactive T and B lymphocytes by antibody therapy in humanized murine SCID model of Systemic lupus erythematosus
P.A.11.03
The immature T cell receptor repertoire impairs the neonatal CD8+ T cell response to influenza infection
P.A.11.04
Influence of surrogate light chain non-Ig parts on B-cell development in vivo
P.A.11.05
Analysis of antigen-specific responses by high throughput sequencing of the T cell receptor repertoire
S. L. Bradyanova1, N. M. Mihaylova2, P. P. Chipinski2, S. H. Chausheva2, T. Velikova3, E. Todorova3, D. Kyurkchiev3, D. Kalinova4, M. Herbath5, J. Prechl5, F. DÁcquisto6, A. Tchorbanov2;
1
Faculty of Biology, Sofia University, Sofia, Bulgaria, 2Institute of Microbiology, BAS, Sofia, Bulgaria, 32Laboratory of Clinical Immunology, University Hospital “St. Ivan Rilski “, Sofia, Bulgaria, 43Clinic of
Rheumatology, University Hospital “St. Ivan Rilski “, Sofia, Bulgaria, 54Immunology Research Group, Hungarian Academy of Sciences, Budapest, Hungary, 65Centre for Biochemical Pharmacology, William
Harvey Research Institute, London, United Kingdom.
A. J. Carey1, D. T. Gracias1,2, J. L. Thayer1, Y. M. Mueller1,3, J. L. Hope1,3, P. D. Katsikis1,3;
1
Drexel University College of Medicine, Philadelphia, PA, United States, 2La Jolla Institute of Immunology, San Diego, CA, United States, 3Erasmus University, Rotterdam, Netherlands.
I. Wolf1, M. Knoll1,2, S. Simmons1,3, F. Melchers1;
1
Max Planck Institute for Infection Biology, Berlin, Germany, 2Whitehead Institute for Biomedical Research, Cambridge, MA, United States, 3Frontier Research Center, Osaka, Japan.
P.A.11.06 Deep sequencing of thymic TCR alpha and beta repertoires in identical twins
N. Heikkilä1, R. Vanhanen1, D. Yohannes1, J. Saramäki2, H. Jarva1,3, H. Sairanen1,4, T. P. Arstila1;
1
University of Helsinki, Helsinki, Finland, 2Aalto University, Espoo, Finland, 3HUSLAB, Helsinki University Central Hospital, Helsinki, Finland, 4Helsinki University Central Hospital, Helsinki, Finland.
P.A.11.07
TCR beta diversity in human thymus
R. Vanhanen1, N. Heikkilä1, J. Saramäki2, P. Arstila1;
1
Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland, 2Department of Biomedical Engineering and Computational Science, Aalto University, Espoo, Finland.
P.A.11.08 Trojan, a possible regulator of apoptosis, belongs to a novel protein family
Tuesday
T. Oakes1, A. L. Popple2, K. Best1, J. Williams3, R. J. Dearman2, I. Kimber2, B. Chain1;
1
University College London, London, United Kingdom, 2University of Manchester, Manchester, United Kingdom, 3Salford Royal NHS Foundation Trust, Salford, United Kingdom.
P. Petrov1, R. Syrjänen1, D. W. Burt2, T. Uchida1, O. Vainio1;
1
Institute of Diagnostics, Department of Medical Microbiology, University of Oulu, Oulu, Finland, 2Division of Genetics and Genomics, The Roslin Institute and R(D)SVS, University of Edinburgh, Roslin,
United Kingdom.
P.A.11.09 Reduced numbers of mature medullary thymic epithelial cells in SKG mice
R. Engelmann, A. Johl, A. Biemelt, B. Müller-Hilke;
University of Rostock, Institute of Immunology, Rostock, Germany.
P.A.11.10
Molecular and phenotypical analysis of soluble human CD6 transgenic mice
P.A.11.11
Notch1 signaling regulates intrathymic cell migration
P.A.11.12
Promiscuous gene expression in medullary thymic epithelial cells is a highly coordinated and evolutionary conserved process
P.A.11.13
Murine medullary thymic epithelial cells express peptidylarginine deiminases and citrullinated proteins
P.A.11.14
The role of HDAC2 in T cells
P.A.11.15
GABPβ2 inhibitory effect on IL7R expression
I. T. Simões1, V. G. Martinez1, E. Carreras1, M. Orta1, M. Mané1, R. Fenutría1, J. Alberola-Ila2, F. Lozano1,3,4;
1
IDIBAPS (Institut d’Investigacions Biomèdicas August Pi i Sunyer), Barcelona, Spain, 2Oklahoma Medical Research Foundation, Oklahoma, OK, United States, 3Servei d’Immunologia, Hospital Clínic de
Barcelona, Barcelona, Spain, 4Departament de Biologia Cel•lular, Immunologia i Neurociències, Universitat de Barcelona, Barcelona, Spain.
B. Bajoghli1, P. Kuri1, D. Inoue2, N. Aghaallaei2, M. Hanelt1, M. Rauzi1, A. Toyoda3, Y. Taniguchi4, J. Wittbrodt2, M. Leptin1;
1
EMBL, Heidelberg, Germany, 2Heidelberg University, Heidelberg, Germany, 3National Institute of Genetics, Shizuoka, Japan, 4Kyorin University School of Medicine, Tokyo, Japan.
K. Rattay, B. Kyewski;
German Cancer Research Center, Heidelberg, Germany.
R. Engelmann, A. Cordshagen, A. Johl, A. Biemelt, B. Müller-Hilke;
University of Rostock, Institute of Immunology, Rostock, Germany.
T. Preglej1, L. Göschl1,2, L. Andersen1, P. Mathias3, C. Seiser4, W. Ellmeier1;
1
Division of Immunobiology, Institute of Immunology, CePII, Medical University of Vienna, Vienna, Austria, 2Division of Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria,
3
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, 4Max F. Perutz Laboratories, Vienna Biocenter, Medical University of Vienna, Vienna, Austria.
B. Shamloo1, B. Atasever1,2, L. Behmoiras1, E. Deniz3,1, J. Eryilmaz1,4, B. Erman1,3;
1
Sabanci University, Istanbul, Turkey, 2Uskudar University, Istanbul, Turkey, 3Sabanci University Nanotechnology Research and Application Center (SUNUM), Istanbul, Turkey, 4SANKO textile, Bursa, Turkey.
P.A.12 Antigen Receptor Signalling
Chairpersons: Jutta Horejs-Hoeck ; Salzburg, Austria (tbc) / Klaus G. Schmetterer; Vienna, Austria
P.A.12.01
Regulation of the Th2 dependent immune response by Swiprosin-1/ EFhd2
P.A.12.02
Transcriptional control of SLAMF1 gene in B-cells
P.A.12.03
CIN85 as a novel marker for X-chromosome-linked antibody deficiency in humans
P.A.12.04
The guanine-nucleotide exchange factor Vav1 controls Ca2+ mobilization in antigen-activated B cells
P.A.12.05
The 3-phosphoinositide-dependent kinase-1 targeting drug BX795 promotes interleukin-2 but shuts off T helper 1 and 2 cytokine secretion upon activation of
allergen-specific T cells
D. Reimer1, V. Wiesmann2, T. Wittenberg2, D. Mielenz1;
1
Division of Molecular Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Image Processing and Medical Engineering Department, Fraunhofer Institute for Integrated Circuits IIS,
Erlangen, Germany.
L. V. Putlyaeva1, A. M. Schwartz1, M. Covic1, K. V. Korneev2, I. E. Vorontsov1,3, K. A. Akulich4, S. E. Dmitriev1,2,4, O. L. Polanovsky1, D. V. Kuprash1,2;
1
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation, 2Faculty of Biology, Lomonosov Moscow State University, Moscow, Russian Federation, 3Vavilov
Institute of General Genetics, Russian Academy of Sciences, Moscow, Russian Federation, 4Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian
Federation.
B. Keller1, M. Shoukier2, K. Schulz3, K. Warnatz1, J. Wienands3;
1
Center for Chronic Immunodeficiency (CCI), Freiburg, Germany, 2Institute of Human Genetics, Göttingen, Germany, 3Cellular and Molecular Immunology, Göttingen, Germany.
C. Hitzing, N. Engels;
Institute of Cellular and Molecular Immunology, Göttingen, Germany.
P. A. Tauber1, M. R. Candia1, D. Trapin1, A. Neunkirchner1,2, W. F. Pickl1,2;
1
Institute of Immunology, Center of Pathophysiology, Infectiology and Immunology, Medical University, Vienna, Austria, 2Christian Doppler Laboratory for Immunomodulation, Center for Pathophysiology,
Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
P.A.12.06 Selective immunosuppressive effects of chloroquine and hydroxychloroquine in CD4+ T-cells
R. L. Schmidt1, F. Ratzinger1, S. Jutz2, P. Steinberger2, W. Pickl2, K. Schmetterer1;
1
Department of Laboratory Medicine, Vienna, Austria, 2Institute of Immunology, Vienna, Austria.
P.A.12.07
A novel, label-free technique to monitor the integrated cellular response of immunocompetent cells
I. Kurucz1, B. Peter2,3, A. Erdei1,4;
1
HAS-ELTE, Immunology Research Group, Budapest, Hungary, 2HAS, Centr for Energy Reasearch, Inst Techn Physics and Materials Science, Budapest, Hungary, 3Doctoral School of Molecular- and
Nanotechnologies, Univ Pannon, Veszprem, Hungary, 4Department of Immunology, Eotvos University, Budapest, Hungary.
P.A.12.08 Studies of immunological synapse formation and downstream signaling events using imaging flow cytometry
H. R. Pugsley1, S. Seth2, K. Eberhart2, S. Friend1, P. Morrissey1;
1
Merck Millipore, Seattle, WA, United States, 2Merck Millipore, Darmstadt, Germany.
47
P.A.12.09 Different potency of macrolide antibiotics in their potential to inhibit CD4+ T-cell activation
F. Ratzinger1, M. Kim1, R. Schmidt1, K. Goldhahn2, B. Klösch2, W. F. Pickl3, K. G. Schmetterer1;
1
Department of Laboratory Medicine, Vienna, Austria, 2Ludwig Boltzmann Cluster for Rheumatology, Balneology and Rehabilitation, Vienna, Austria, 3Institute of Immunology, Vienna, Austria.
Tuesday
P.A.12.10
Rapid multiplex analysis of lipid raft components with single cell resolution
P.A.12.11
Characterization of the CD22 and Siglec-G interactomes
P.A.12.12
A cell membrane permeable phosphopeptide of Grb2 associated binder (Gab1) modulates B cell activation by interacting with SHP2 phosphatase
P.A.12.13
Contact-dependent and -independent mixed lymphocyte cultures result in different phenotypes of responder CD4+ T cells and cell-derived vesicles
P.A.12.14
Study of electrical activity and vesicular exocytosis during activation of human T lymphocytes
P.A.12.15
Specific suppression of CD4+ T-cell proliferation and metabolic activity by the tryptophan metabolite picolinic acid
P.A.12.16
Angiopoietin-1 and -2: Full and differential agonists of human neutrophil biological activities
P. Schatzlmaier, J. B. Huppa, H. Stockinger;
Institute for Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria.
S. Mrotzek1, A. Böser2, B. Warscheid2, L. Nitschke1;
1
Friedrich-Alexander University of Erlangen, Erlangen, Germany, 2Albert-Ludwigs University of Freiburg, Freiburg, Germany.
E. Szarka1, D. Szili1, Á. Kertész1, J. Varga2, Á. Garai2, G. Gógl2, A. Alexa3, T. Janáky4, G. Váradi4, G. Tóth4, A. Reményi3, G. Sármay1;
1
Department of Immunology, Eötvös Loránd University, Budapest, Hungary, 2Department of Biochemistry, Eötvös Loránd University, Budapest, Hungary, 3Institute of Enzymology, Research Centre for
Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary, 4Department of Medical Chemistry, University of Szeged, Szeged, Hungary.
A. S. Revenfeld, A. Elbæk, K. Varming;
Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark.
E. Petrovcikova1, K. Pfisterer2, M. Hotka1, I. Zahradnik1, V. Leksa1;
1
Slovak Academy of Sciences, Bratislava, Slovakia, 2MUW, Vienna, Austria.
J. Prodinger1, G. Greiner1, F. Ratzinger1, R. Schmidt1, G. Hörmann1, S. Jutz2, P. Steinberger2, W. F. Pickl2, K. G. Schmetterer1;
1
Department of Laboratory Medicine, Vienna, Austria, 2Institute of Immunology, Vienna, Austria.
M. G. Sirois1, E. Dumas1, D. Chaar1, S. Lavoie1, P. Neagoe1, P. P. McDonald2, M. White1;
Montreal Heart Institute, Montreal, QC, Canada, 2Université de Sherbrooke, Sherbrooke, QC, Canada.
1
P.A.12.17
Ligands for inhibitory and activating NK cell receptor in T, B and myeloid acute childhood leukemia
M. V. Martínez-Sánchez1, J. F. Pascual-Gázquez2, L. Gimeno-Arias1, A. M. Galera-Miñarro2, M. M. Bermúdez-Cortés2, M. Blanquer-Blanquer3, A. M. García-Alonso1, J. M. Moraleda-Jiménez3, J. L. FusterSoler2, A. Minguela-Puras1;
1
Immunology Service. Hospital Clínico Universitario Virgen de la Arrixaca. Instituto Murciano de Investigación Biomédica, El Palmar-Murcia, Spain, 2Oncology Service. Hospital Clínico Universitario Virgen
de la Arrixaca. Instituto Murciano de Investigación Biomédica, El Palmar-Murcia, Spain, 3Haematology Service. Hospital Clínico Universitario Virgen de la Arrixaca. Instituto Murciano de Investigación
Biomédica, El Palmar-Murcia, Spain.
P.A.12.18 NKG2D variability in patients with cutaneous malignant melanoma
L. Gimeno1, H. Martínez-Banaclocha1, M. Bernardo-Pisa1, J. Bolarin1, M. Muro1, R. López-Hernández1, L. Marín2, B. Las Heras Ferre1, M. Moya-Quiles1, A. Minguela1, A. Mrowiec1, I. Legaz1, M. MartinezSanchez1, J. Frias3, A. García-Alonso1, M. Álvarez-López1, J. Martínez-Escribano3, J. Campillo1;
1
Immunology Service.Hospital Clinico Universitario Virgen de la Arrixaca.Servicio Murciano de Salud-IMIB, El Palmar-Murcia, Spain, 2Department of Hematology, University Hospital., Salamanca, Spain,
3
Dermatology Service.Hospital Clinico Universitario Virgen de la Arrixaca.Servicio Murciano de Salud-IMIB, El Palmar-Murcia, Spain.
P.A.12.19
Scavenger receptor type A-mediated expression of CCL21 in spleen and lymph nodes
T. Kim1,2, C. Kim1,3, H. Bae2, J. Kwak1,3;
1
Immune-network Pioneer Research Center, Ajou University Medical Center, Suwon 443-380, Korea, Republic of, 2Department of Physiology, College of Medicine, Dong-A University, Busan 602-714, Korea,
Republic of, 3Department of Pharmacology, School of Medicine Ajou University, Suwon 443-380, Korea, Republic of.
Chairpersons: Louise Boyle; Cambridge, United Kingdom (tbc) / Anne Hosmalin; Paris, France
48
P.A.13.01
Changes in the immunological properties induced by glycofullerenes and nanohorns
P.A.13.02
Controllable mitogenic response by peptidoglycan-activated macrophages loaded on laser micro-structured Si scaffolds
P.A.13.03
Anti-tumor response elicited by the necrotic tumor cell-stimulated macrophage
P.A.13.04
Destruction of glycosylating enzymes is necessary for functional MHC class I
P.A.13.05
Evasion of immune system response by Microsporidia infection: modulation of MHC-I expression and antigenic presentation
P.A.13.07
Capture and processing of opsonized HIV-1 in immature and differentially matured DCs
P.A.13.08
Innate responses and antigen-presenting capacity of oral epithelial cells
P.A.13.09
Human blood plasmacytoid Dendritic Cells cross-present antigens from live cells
P.A.13.10
Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity
P.A.13.11
Immune reactions against Gene Gun vaccines are differentially modulated by distinct dendritic cell subsets in the skin
P.A.13.12
Tapasin is a key component to understand immunogenicity in glioblastoma
P.A.13.13
How antigen is presented to sensitize T-cells
P.A.13.14
Monocytes Pulsed with Liposomes Co-encapsulating D-Type CpG ODN and an Antigen Differentiate into Functional DCs and Elicit Antigen-Specific Effector T-cells
M. Palomares Jerez1, T. Fernandez Duarte1, A. Muñoz2, B. Illescas2, M. Nazario2, R. Maria Jose1, G. Luisa1, R. Javier3, T. Maria Jose1, M. Cristobalina1;
1
IBIMA-HRUM, Malaga, Spain, 2Department of Organic Chemistry Faculty of Chemistry, Universidad Complutense de Madrid, Spain, 3Glycosystems Laboratory Institute for Chemical Research (IIQ), CSIC
Universisdad de Sevilla, Spain.
E. Katsoni1, I. Zerva1, C. Simitzi1,2, A. Ranella2, E. Stratakis2, I. Athanassakis1;
1
Biology Department, University of Crete, Heraklion, Greece, 2Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology, Heraklion, Greece.
X. Yuan;
The Affiliated Hospital of Dalian University, Dalian, China.
M. Jongsma1, V. Blomen2, M. Raaben2, P. van Veelen3, R. Plomp3, T. van der Heijden2, L. Janssen2, G. Janssen3, A. Mulder3, F. Claas3, M. Griffioen3, M. Heemskerk3, M. Wührer3, T. Brummelkamp2, J. Neefjes2,
R. Spaapen1,2;
1
Sanquin Research, Amsterdam, Netherlands, 2The Netherlands Cancer Institute, Amsterdam, Netherlands, 3Leiden University Medical Center, Leiden, Netherlands.
C. Hurtado, I. Silvela, J. Aguilar, A. Magnet, F. Izquierdo, S. Fenoy, C. del Aguila;
Universidad San Pablo-CEU, Madrid, Spain.
U. Knackmuss, W. Posch, M. Steger, M. Blatzer, C. Lass-Flörl, D. Wilflingseder;
C. Kitzmueller, M. Schuschnig, B. Bohle;
Christian Doppler Laboratory for Immunomodulation, Institute for Pathophysiology, Vienna, Austria.
S. Isnard, L. Vimeux, M. Iannetta, J. Manuzak, V. Feuillet, M. Valente, A. Schaefer, J. Guillerme*, A. Hosmalin*;
Institut Cochin, Inserm U1016, CNRS UMR 1084, Université Paris-Descartes, AP-HP, Paris, France.
H. Brandstetter;
University of Salzburg, Salzburg, Austria.
C. Weber1, K. Hainz1, T. Deressa1, H. Strandt1, D. Florindo Pinheiro1, R. Mittermair1, J. Pizarro Pesado1, P. Hammerl1, J. Thalhamer1, A. Stoecklinger1,2;
1
University of Salzburg, Salzburg, Austria, 2Christian Doppler Laboratory for Allergy Diagnosis and Therapy, University of Salzburg, Austria.
C. Thuring1, L. Geironson1, E. Freyhult2, S. Buus3, K. M. Paulsson1;
1
Experimental Medical Science, Lund, Sweden, 2Medical Science, SciLifeLab, Uppsala, Sweden, 3Experimental Immunology, Copenhagen, Denmark.
R. Platzer1, M. Brameshuber2, G. Schütz2, H. Stockinger1, J. Huppa1;
1
H. Koksal, B. Bayyurt;
Bilkent University, Ankara, Turkey.
P.A.13.15
Role of PD-1/PD-L interactions in hepatocyte-dependent CD8+ T cell tolerance
P.A.13.16
Presentation of bacterial and viral antigens by antigens-presenting T cells
P.A.13.17
Chasing recycled MHC class I molecules
P.A.13.18
Late endosomal trafficking and endosecretory recycling route of open MHC-I conformers
M. Damo, D. S. Wilson, J. A. Hubbell;
EPFL, Lausanne, Switzerland.
V. Boccasavia, B. Alarcon;
Centro de Biologia Molecular Severo Ochoa, Madrid, Spain.
G. Blagojević Zagorac1, H. Mahmutefendic1, S. Mačešić, L. Karleuša, P. Lučin;
1
Medical faculty University of Rijeka, Rijeka, Croatia, 2Tehnical faculty University of Rijeka, Rijeka, Croatia.
H. Mahmutefendić1, G. Blagojević Zagorac1, K. K. Grabušić, L. Karleuša, F. Momburg3, P. Lučin1;
1
Department of Physiology and Immunology, Medical faculty University of Rijeka, Rijeka, Croatia, 2Department of Biotechnology, University of Rijeka, Rijeka, Croatia, 3Division of Translational Immunology,
German Cancer Research Center and NCT, Heidelberg, Germany.
P.A.14.01
Phagocytosis of apoptotic cells infected with Streptococcus pneumoniae by dendritic cells induce differentiation of Th1 cells
P.A.14.02
Predicting T-helper cell differentiation and plasticity using logical modelling and model-checking
V. Niño1, N. Dejani1,2, F. Verdan1,2, A. I. Medeiros1;
1
Universidade Estadual Paulista, Araraquara, Brazil, 2University of São Paulo, Ribeirão Preto, Brazil.
W. Abou-Jaoudé1, M. Grandclaudon2, P. T. Monteiro3, C. Chaouiya4, V. Soumelis2, D. Thieffry1;
IBENS, Paris, France, 2Laboratoire d’Immunologie Clinique de l’Institut Curie, Paris, France, 3Instituto de Engenharia de Sistemas e Computadores - Investigação e Desenvolvimento, Lisbon, Portugal,
Instituto Gulbenkian de Ciência, Oeiras, Portugal, Lisbon, Portugal.
1
4
P.A.14.03
Isolation of untouched rat T cells and T cell subsets in less than 20 minutes
S. de Jong1, P. Morin1, N. MacDonald1, M. Nauer1, M. Fairhurst1, T. Thomas1, A. Eaves1,2;
1
STEMCELL Technologies Inc., Vancouver, BC, Canada, 2Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada.
Tuesday
Chairpersons: Valerie Julia; Valbonne, France / Federica Sallusto; Bellinzona, Switzerland
P.A.14.04 Activation induced expression of LAT adaptor is mediated by an Sp1/Sp3 based mechanism
K. Marek-Bukowiec, A. Miazek;
Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
P.A.14.05
Analysis of T cell signaling using vector-mediated RNAi of CTLA4 in human leukaemia T cells
R. Vassileva1, F. Ryan1, J. Kelly2, J. Curtin1;
1
Dublin Institute of Technology, Dublin, Ireland, 2National Children’s Research Centre, Dublin, Ireland.
P.A.14.06 Stable Th2 cells mediate suppression of virus-specific T cell responses via IL-10
M. Munoz1, A. Hegazy2, P. Saikali1, A. Froehlich1, M. Loehning1;
1
DRFZ-Charité, Berlin, Germany, 2University of Oxford, London, United Kingdom.
P.A.14.07
Inhibitor of DNA binding 2 (Id2) controls CD4+ T cell differentiation
L. Shaw1, K. Omilusik1, J. Scott-Browne2, I. Bilic3, M. Busslinger3, A. Goldrath1;
1
University of California San Diego, La Jolla, CA, United States, 2La Jolla Institute for Allergy and Immunology, La Jolla, CA, United States, 3Research Institute of Molecular Pathology, Vienna, Austria.
P.A.14.08 Modulation of immune responses by stable quantitative regulation of T helper cell functions
M. Peine1, C. Helmstetter1, M. Flossdorf2, S. Rausch3, A. Kupz4, A. Fröhlich1, A. N. Hegazy1, J. Zhu5, A. A. Kühl1, A. Radbruch6, S. H. Kaufmann4, W. E. Paul5, S. Hartmann3, T. Höfer2, M. Löhning1;
1
Charité, Berlin, Germany, 2DKFZ, Heidelberg, Germany, 3Freie Universität, Berlin, Germany, 4Max-Planck Institute for Infection Biology, Berlin, Germany, 5NIH, Bethesda, MD, United States, 6DRFZ, Berlin,
Germany.
P.A.14.09 Chemokine Receptors and Cytokine Profile of T Lymphocytes in Human Asthma
L. Cevhertas1, A. Yilmaz1, I. Tahrali1, U. C. Kucuksezer1, B. Gemicioglu2, G. Deniz1, G. Erten1;
1
Istanbul University, Institute of Experimental Medicine, Immunology Department, Istanbul, Turkey, 2Istanbul University, Cerrahpasa Faculty of Medicine, Department of Pulmonary Diseases, Istanbul,
Turkey.
P.A.14.10
Dopamine receptors D3 and D5 regulate CD4+ T-cell activation and differentiation by modulating ERK activation and cAMP production
P.A.14.11
Treatment of human T cells with tetanus neurotoxin Hcc recombinant protein causes T cell activation and IFN-γ secretion
P.A.14.12
The effect of heavy chain carboxy terminal (HCC) subdomain of tetanus toxin on purified human T lymphocytes
P.A.14.13
A high-dimensional profile of TH cell specialisation and effector functions
R. Pacheco1,2, D. Franz1, F. Contreras1, F. Osorio1, H. González1, C. Prado1, D. Elgueta1,2;
1
Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, Santiago, Chile, 2Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago, Chile.
S. Sadreddini1, S. Sadreddini1, A. Afkham1, V. Younesi2, M. Yousefi1;
1
Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, ,, Tabriz, Iran, Islamic Republic of, 22 Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR ,,
Tehran, Iran, Islamic Republic of.
M. Ghaffari_Khameneh1, M. Hosseini2, M. Haji-Fatahaliha2, S. Rasoulzadeh2, D. Shanehbandi2, L. Aghebati2, M. Shabani3, M. Yousefi2;
1
Islamic Azad University, Urmia, Iran, Islamic Republic of, 2Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of, 3Avicenna Research Institute, Tehran, Iran, Islamic Republic of.
F. J. Hartmann1, D. Mrdjen1, C. Krieg1, T. Olsson2, B. Becher1;
1
University of Zurich, Zurich, Switzerland, 2Karlolinska Institutet, Stockholm, Sweden.
P.A.14.14 Interferon Regulatory Factor 4 controls Th1 effector function and metabolism
F. Raczkowski, J. Mahnke, V. Schumacher, H. Mittrücker;
Institute for Immunology, Hamburg, Germany.
P.A.14.15
Tetanus Neurotoxin Hcc Subdomain commits T cell to be TH1 IFN-γ producing cells
V. Younesi1, S. Sadreddini2, M. Seifi-Najmi2, S. Sadreddini2, M. Yousefi3;
1
Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran, Islamic Republic of, 2Tabriz University of Medical Scinces, Tabriz, Iran, Islamic Republic of, 3Tabriz University
Medical Of sciences, Tabriz, Iran, Islamic Republic of.
P.A.14.16 Regulation of Th2 cell development by Grail
R. Nurieva, A. Sahoo, A. Alekseev;
MD Anderson Cancer Center, Houston, TX, United States.
P.A.14.17
Acetyltransferase Tip60 interacts with transcriptional silencer Ets-2 to initiate IL-2 transcription
I. Aggeletopoulou, I. Panagoulias, F. Karagiannis, T. Georgakopoulos, A. Mouzaki;
Division of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Patras, Patras, Greece.
P.A.14.18 Molecular analysis of MAZR function in CD4+ T cells
L. Andersen, A. Gülich, A. Schebesta, S. Sakaguchi, W. Ellmeier;
Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
P.A.14.19 CD4+CD25+FOXP3+ T regulatory cells, Th1 (CCR5, IL-2, IFN-γ) and Th2 (CCR4, IL-4, IL-13) type chemokine receptors and intracellular cytokines in children with
common variable immunodeficiency
E. Azarsiz, N. Kutukculer, G. Aksu, N. E. Karaca;
Ege University Medical faculty Dep of Pediatric Immunology, Izmir, Turkey.
P.A.14.20
The E3 ubiquitin ligase Cbl-b limits Th9 differentiation
I. Cornez1, S. Parampalli Yajnanarayana1, N. Hermann-Kleiter2, S. Schmidt3, P. Brossart1, N. Garbi4, G. Baier2, D. Wolf1,3;
Department of Internal Medicine III, Oncology, Hematology and Rheumatology, University Clinic Bonn (UKB), Bonn, Germany, 2Department for Pharmacology and Genetics, Division of Translational Cell
Genetics, Innsbruck Medical University, Innsbruck, Austria, 3Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria, 4Institute of Molecular Medicine and Experimental Immunology (IMMEI),
University Clinic Bonn (UKB), Bonn, Germany.
1
49
P.A.14.21
Investigating differential T-cell polarization in the two pathological forms of sheep paratuberculosis
L. Nicol1, A. Gossner1, C. Watkins2, R. Dalziel1, J. Hopkins1;
1
Roslin Institute, Midlothian, United Kingdom, 2Moredun Research Institute, Midlothian, United Kingdom.
Chairpersons: Vivianne Malmström; Stockholm, Sweden (tbc) / Jasper Koning; Amsterdam, Netherlands (tbc)
Tuesday
P.A.15.01
Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis that can be controlled by steroids or biologicals
P.A.15.02
Semaphorin 3a/plexinA4/neuropilin-1 form a functional B7-H4 receptor complex
P.A.15.03
The transcriptional regulator Bcl-3 impaires the function of regulatory T cells leading to the development of intestinal inflammation
P.A.15.04
Subtype-specific Ca2+ signaling in human effector CD4+ T cells
P.A.15.05
TGF-β induces CD39 expression on regulatory T (Treg) cells by a mechanism dependent of the SMAD2/CREB pathway
M. Hardtke-Wolenski, K. Fischer, F. Noyan, J. Schlue, C. S. Falk, J. Dywicki, R. Taubert, M. P. Manns, E. Jaeckel;
J. R. Podojil1, M. Chiang1, W. Burke1, L. Liu2, S. Langermann2, D. A. Vignali3, S. D. Miller1;
1
Northwestern University, Chicago, IL, United States, 2Amplimmune, Inc, Gaithersburg, MD, United States, 3University of Pittsburgh, Pittsburgh, PA, United States.
S. Reißig, A. Nikolaev, A. Waisman, N. Hövelmeyer;
Uniklinik Mainz, Mainz, Germany.
S. C. Kircher, B. A. Niemeyer, D. Alansary;
Molecular Biophysics Saarland University, Homburg, Germany.
R. S. Peres1, J. Talbot1, P. B. Donate1, R. D. Oliveira1, J. C. Alves-Filho1, T. M. Cunha1, F. Liew2, F. Q. Cunha1;
1
University of São Paulo, Ribeirão Preto, Brazil, 2University of Glasgow, Glasgow, United Kingdom.
P.A.15.06 Distinct tolerogenic signals differentially regulate CD39 expression in CD4+ T-cells
M. Gerner1, J. Leitner2, P. Steinberger2, C. Gerner3, K. G. Schmetterer1;
1
Department of Laboratory Medicine, Vienna, Austria, 2Institute of Immunology, Vienna, Austria, 3Institute of Analytical Chemistry, Vienna, Austria.
P.A.15.07
Increase in the frequency of CD4+CD39+ cells in SCD compared to healthy controls
U. Al-Maskari, M. Boulssel, H. Al-Ghaithi, A. Alansari;
Sultan Qaboos University, Al-Khoud, Oman.
P.A.15.08 Expansion of cynomolgus monkey alloantigen-reactive regulatory T cells using activated B cells for in vivo testing
H. Zhang1, H. Guo1, L. Lu1, Q. Tang2, M. Ezzelarad1, A. Thomson1;
1
university of pittsburgh, pittsburgh, PA, United States, 2university of California at San Francisco, San Francisco, CA, United States.
P.A.15.09 CD8+ Treg differentiation and function is dependent on pro-inflammatory cytokines
U. Bjarnadóttir1, B. R. Lúðvíksson1,2;
1
Department of Immunology, Landspitali, National University Hospital of Iceland, Reykjavík, Iceland, 2Faculty of Medicine, Biomedical Center, University of Iceland, Reykjavík, Iceland.
P.A.15.10
Regulatory t, natural killer t and gamma delta t cells in multiple sclerosis and chronic Fatigue syndrome/myalgic encephalomyelitis: a comparison
P.A.15.11
Functional defects in regulatory T cells are age dependent in new-onset Type 1 Diabetes and First Degree Relatives
P.A.15.12
The influence of urban air pollution on the changes in immunological status and in concentration of BTEX
P.A.15.13
Blockage of FOXP3 dimerization or FOXP3/AML1 interaction with a synthetic peptide inhibits T regulatory cell activity
P.A.15.14
Can Foxp3+ regulatory T cells synthesize and secrete catecholamines?
P.A.15.15
Role of HIF-2α in T cell differentiation and regulatory T cell function
P.A.15.16
The role of human β-defensin 2 in T cell activation and proliferation
P.A.15.17
Foxp3+ T cells expressing RORgammat represent a regulatory T effector lineage with enhanced suppressive capacity during intestinal inflammation
P.A.15.18
Reduced numbers and suppression capacity of regulatory T cells in PCOS
P.A.15.19
Differential effects of TNF-blocking agents on regulatory T-cells in axial spondyloarthritis
S. Ramos, T. Nguyen, S. Marshall-Gradiskin;
Menzies Health Institution, Gold Coast, Australia.
G. Treiber1, B. Prietl1,2, E. Fröhlich-Reiterer1, M. Tauschmann1, V. Pfeifer1,2, E. Lechner1,2, W. Graninger1, T. R. Pieber1,2;
1
Medical University Graz, 8036 Graz, Austria, 2CBmed Center for Biomarker Research in Medicine, Graz, Austria.
I. Mrakovcic-Sutic1, A. Bulog2, V. Micovic2, I. Sutic3, Z. Baricev-Novakovic3;
1
Department of Physiology and Immunology, Medical Faculty, Rijeka, Croatia, 2Department of Public Health, Medical Faculty, Rijeka, Croatia, 3Department of Family Medicine, Medical Faculty, Rijeka,
Croatia.
T. Lozano, M. Gorraiz, M. Durantez, M. Ruiz, V. Belsúe, O. Rabal, J. Oyarzabal, P. Sarobe, J. Prieto, N. Casares, J. J. Lasarte;
Centre for Applied Medical Research, CIMA, Pamplona, Spain.
M. G. Guereschi, J. T. Maricato, L. P. Araujo, F. M. Melo, A. S. Basso;
Department of Microbiology, Immunology and Parasitology, Paulista Medical School, Federal University of São Paulo, São Paulo, Brazil.
Y. Lin, M. Lai;
Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
D. Chen, J. George, D. Rowley, S. Outram;
School of Health, Sport & Bioscience, University of East London, London, United Kingdom.
S. C. Hagemann1, B. Yang2, P. Mamareli1, T. Sparwasser1, S. Floess2, J. Huehn2, M. Lochner1;
1
Twincore, Hannover, Germany, 2Helmholtz Centre for Infection Research, Braunschweig, Germany.
T. Madhwani, A. Patil, S. Khavle, G. Shinde, S. Mukherjee;
National Institute for Research in Reproductive Health (ICMR), Mumbai, India.
K. Maly, S. Kemmerling, M. Schirmer;
Medical University of Innsbruck, department of internal medicine, clinic VI, Innsbruck, Austria.
Chairpersons: Iris K. Gratz; Salzburg, Austria / Juan J. Lasarte; Pamplona, Spain
P.A.16.01 Characterization of resident T cells within secondary lymphoid organs
A. Audemard-Verger, A. Durand, A. Delpoux, R. Mattiuz, N. Bonilla, B. Martin, C. Auffray, B. Lucas;
Institut Cochin, Paris, France.
P.A.16.02
Adenosine-A2a receptor orchestrates regulatory T cells expansion and promotes sepsis-induced immunosuppression
P.A.16.03
Antigen dose defines T cell fate in vivo: effector versus regulatory T cells
D. C. Nascimento, P. H. Mello, A. Pineros, R. G. Ferreira, P. B. Donate, R. S. Peres, V. C. Pereira, F. Q. Cunha, J. C. Alves-Filho;
University of Sao Paulo, Ribeirão Preto, Brazil.
D. F. Pinheiro1, M. M. Klicznik1, R. Holly1, S. K. Kitzmueller1,2, M. M. Maurano1,2,3, G. Achatz-Straussberger1, J. Thalhamer1, A. K. Abbas4, I. K. Gratz1,2,3;
1
Department of Molecular Biology, University of Salzburg, Salzburg, Austria, 2Division of Molecular Dermatology and EB House, Salzburg, Austria, 3Department of Dermatology, University of California San
Francisco, San Francisco, CA94143, CA, United States, 4Department of Pathology, University of California San Francisco, San Francisco, CA94143, CA, United States.
P.A.16.04 Role of sphingolipids in the regulation of anti-viral T cell responses in persistent viral CNS infection
C. Hollmann, J. Schneider-Schaulies, N. Beyersdorf;
Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
P.A.16.05 Immunotoxicity of orally administered silica nanoparticles
I. Gmoshinski, E. Trushina, O. Mustaphina, S. Khotimchenko, R. Khanferyan;
Institute of Nutrition, Moscow, Russian Federation.
50
P.A.16.06 Senescent Tregs occur in RA and are distinct from conventional Tregs
J. Fessler, A. Ficjan, R. Husic, A. Lackner, W. Graninger, C. Dejaco;
Medical University Graz, Graz, Austria.
P.A.16.07 Inhibition of FOXP3:NFAT interaction enhances T cell proliferation and cytokine production after TCR stimulation
T. Lozano1, L. Villanueva1, M. Durantez1, M. Gorraiz1, M. Ruiz1, V. Belsúe1, J. I. Riezu-Boj1, J. Oyarzabal1, H. Bandukwala2, P. Sarobe1, J. Prieto1, N. Casares1, N. Casares1, J. J. Lasarte1,3,4;
1
Centre for Applied Medical Research, CIMA, Pamplona, Spain, 2La Jolla Institute for Allergy and Immunology, San Diego, CA, United States, 3Universiy of Navarra, Pamplona, Spain, 4IDISNA, Pamplona,
Spain.
P.A.16.08 Distinct surface marker expression of Th9 cells indicates suppression of Th1 responses
K. Stanko, J. Schumann, K. Vogt, S. Schlickeiser, C. Appelt, B. Sawitzki;
Charité - University Medicine Berlin, Institute of Medical Immunology, Berlin, Germany.
P.A.16.09 Donor MHC-derived peptide recognized by TCR biased-CD8+ Tregs suppresses organ rejection
E. Picarda1, S. Bézie1, V. Venturi2, K. Echasserieau3, K. Bernardeau3, I. Anegon1, C. Guillonneau1;
INSERM UMR1064, Nantes, France, 2University of New South Wales, Kensington, Australia, 3Plateforme de protéines recombinantes P2R IFR26, Nantes, France.
1
P.A.16.10 Lack of CD154 expression discriminates stable from instable Foxp3-expressing CD137+ Treg
P.A.16.11
Fam65b a new molecular link between RhoA and TGF-β signaling pathways in iTregs differentiation
P.A.16.12
The frequencies of peripheral blood regulatory T cells and T helper 17 cells in idiopathic dilated cardiomyopathy
P.A.16.13
Study on the role of galectins in the regulatory function of Regulatory T cells induced by B cells
J. Froehlich1,2,3, L. Bertrand1,2,3, A. Lainé1,2,3, J. Delon1,2,3, C. Charvet1,2,3, M. Mangeney1,2,3;
1
Inserm U1016, Institut Cochin, Paris, France, 2CNRS, UMR8104, Paris, France, 3Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
D. Stettner-Leonkiewicz, E. Grywalska, J. Rolinski, A. Wysokinski;
Medical University of Lublin, Lublin, Poland.
Y. C. Tsai, C. C. Yang, B. L. Chiang;
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan.
P.A.16.14 Rheumatoid arthritis alters the phenotype of bone-marrow-resident Tregs
Tuesday
A. Nowak1, P. Bacher2, T. Hohnstein2, K. Vogt3, B. Sawitzki3, A. Thiel4, A. Scheffold1,2;
1
German Rheumatism Research Centre (DRFZ) Berlin, Leibniz Association, Berlin, Germany, 2Clinic for Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany,
3
Institute for Medical Immunology, Charité - University Medicine Berlin, Berlin, Germany, 4Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - University Medicine Berlin, Berlin,
Germany.
M. Massalska1, M. Plebanczyk1, M. Prochorec-Sobieszek2,3, A. Radzikowska1, E. Kuca-Warnawin1, U. Musialowicz1, U. Skalska1, A. Kornatka1, T. Burakowski1, P. Maldyk4,5, E. Kontny1, W. Maslinski1, W.
Maslinski1;
1
Dept of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland, 2Dept of Pathology, Institute of Rheumatology, Warsaw, Poland, 3Dept of Diagnostic Haematology, Institute of
Haematology and Transfusion Medicine, Warsaw, Poland, 4Department of Rheumoorthopaedic Surgery, Institute of Rheumatology, Warsaw, Poland, 5Clinical Dept of Orthopaedic and Traumatology of
Locomotor System, Enfant-Jesus Clinical Hospital, Warsaw, Poland.
P.A.16.15
Tuning IL-2 signaling by ADP-ribosylation of CD25
F. Koch-Nolte1, S. Teege1, A. Hann1, M. Miksiewicz1, C. Mac-Millan1, B. Rissiek1, B. Rissiek1, S. Menzel1, M. Nissen1, M. Nissen1, F. Haag1, S. Adriouch2;
1
University Medical Center Hamburg, Hamburg, Germany, 2University Hospital, Rouen, France.
P.A.16.16 Immunomodulatory effects of allogeneic blood transfusion (ABT)
P. Spadidea1, M. Rodi1, A. G. Kastrenopoulou1, I. Tatani2, A. Chatziantoniou2, E. Panagiotopoulos2, A. Mouzaki1;
Division of Hematology, Dpt. of Internal Medicine, School of Medicine, University of Patras, Patras, Greece, 2Orthopedics Clinic, Medical School and University Hospital, University of Patras, Patras, Greece.
1
P.A.16.17
A significant fraction of neonatal regulatory T cells is preserved throughout life.
C. F. Nunes1, J. Nogueira1, F. Canto1, P. Vianna1, M. Bellio1, A. Nóbrega1, R. Fucs2;
1
UFRJ, Rio de Janeiro, Brazil, 2UFF, Rio de Janeiro, Brazil.
P.A.16.18 Association of -3279 C/A (rs3761548) polymorphism in the FoxP3 gene with susceptibility to bronchial asthma in Slovak population
M. Olejarova1, B. Gajdosechova1, J. Javor1, M. Suchankova1, E. Tibenska2, E. Tedlova3, J. Demian3, I. Majer3, H. Novosadova3, M. Tedla4, M. Bucova1;
1
Institute of Immunology, Faculty of Medicine, Comenius University, Bratislava, Slovakia, 2Medirex Ltd., Bratislava, Slovakia, 3Department of Pneumology and Phthisiology, Faculty of Medicine, Comenius
University, Bratislava, Slovakia, 41st Department of Otorhinolaryngology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Chairpersons: Vincenzo Barnaba; Rome, Italy / Deborah Palliser; Bronx, United States
P.A.17.01
Effect of age and CMV latent infection on CD8+CD56+ T cells (NKT-like) frequency and functionality
P.A.17.02
Characterization of NLRC3-deficient mice upon viral infection
P.A.17.03
Vaccination with MHC class I synthetic long peptides provokes the induction of vigorous and polyfunctional CD8 T cells responses that protect against acute
MCMV infection
F. Hassouneh1, C. Campos1, N. López-Sejas1, C. Alonso1, R. Tarazona2, R. Solana1, A. Pera1;
1
Department of Immunology, Maimonides Institute for Biomedical Research (IMIBIC) – Reina Sofía University Hospital – University of Cordoba, Cordoba, Spain, 2Immunology Unit, Department of
Physiology, University of Extremadura, Cáceres, Spain.
A. Dang1, W. Castro1, K. Ludigs1, M. Rebsamen2, G. Guarda1;
1
University of Lausanne, Epalinges, Switzerland, 2CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
E. Panagioti, A. Redeker, S. van Duikeren, J. W. Drijfhout, S. van der Burg, R. Arens;
Leiden University Medical Center, Leiden, Netherlands.
P.A.17.04
Different modulation of polyfunctional CD8 T cell response by cART in primary and chronic HIV infection
P.A.17.05
Inhibition of T-cell apoptosis reprograms M2 into M1 macrophages in mice infected with Trypanosoma cruzi
P.A.17.06
Decreased polyfunctionality of CD8+ T cells in sepsis patients with cytomegalovirus reactivation
P.A.17.07
SIDT1 as a marker of highly functional memory CD8+ T cells
P.A.17.08
Novel regulatory candidates of NK and CD8+ T-cells dependent cytotoxicity as identified by microarray analysis
P.A.17.09
A molecular basis for broad αβTCR cross-recognition of influenza A viruses
P.A.17.10
T cells and CMV in acute myocardial infarction
P.A.17.11
Relationship between CD4 and CD8 T cell and the presence of the parasite in organs of dogs with visceral leishmaniasis
R. Casetti, G. De Simone, C. Pinnetti, F. Besi, A. Sacchi, I. Abbate, G. Rozera, P. Pierro, C. Agrati, E. Cimini, V. Bordoni, N. Tumino, D. Viola, M. Capobianchi, A. Antinori, F. Martini, A. Ammassari;
National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy.
M. P. Piccin, L. C. Guillermo, N. S. Vellozo, S. P. Marques, W. F. Pereira-Manfro, T. S. Rigoni, G. A. DosReis, M. F. Lopes;
Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Y. Choi, E. Shin;
Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of.
E. Yakob, J. A. Katakowski, R. Furtado, S. M’Homa Soudja, G. Lauvau, D. Palliser;
AECOM, Bronx, NY, United States.
E. C. Schwarz1, K. Friedmann1, A. Knörck1, C. Hoxha1, G. Schwär1, C. Backes2, P. Leidinger3, M. Hamed2, V. Helms2, E. Meese3, E. Meese3, A. Keller2, M. Hoth1;
1
Biophysics, Homburg, Germany, 2Center of Bioinformatics, Saarbrücken, Germany, 3Human Genetics, Homburg, Germany.
S. M. Quiñones Parra1, A. Uldrich1, A. C. Boon2, G. F. Rimmelzwaan3, D. I. Godfrey1, J. Rossjohn4, S. Gras4, K. Kedzierska1;
1
Department of Microbiology and Immunology, University of Melbourne, at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia, 2Department of Medicine, Washington University
School of Medicine, St Louis, WA, United States, 3Department of Viroscience, Erasmus Medical Centre, Rotterdam, Netherlands, 4Department of Biochemistry and Molecular Biology, School of Biomedical
Sciences, Monash University, Melbourne, Australia.
S. Murali1, E. Shmeleva2, S. Boag2, J. Hoffmann2, I. Spyridopoulos2, S. Todryk1;
1
Northumbria University, Newcastle Upon Tyne, United Kingdom, 2Newcastle University, Newcastle Upon Tyne, United Kingdom.
P. R. R Moreira, F. S. Fernando, H. J. Montasier, R. O. Vasconcelos;
Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil.
51
P.A.17.12
Engineering of chimeric T-cell receptors based on single chain VHH antibodies of Vicugna pacos
P.A.17.13
Imaging antigen recognition of human T-cells in health and disease
P.A.17.14
T cells expressing two additional receptors (TETARs) form a multiple-hit therapy against melanoma
Y. Lezhnin1,2, S. Chumakov1,2, P. Chumakov1;
1
Engelhardt Institute of molecular biology, Moscow, Russian Federation, 2Institute of bioorganic chemistry of the Russian Academy of Sciences, Moscow, Russian Federation.
L. Scharf, T. Stary, S. Königsberger, J. B. Huppa;
U. Uslu1, S. Höfflin1, S. Prommersberger1, G. Schuler1, C. W. Schmidt2, V. Lennerz3, J. Dörrie1, N. Schaft1;
Universitätsklinikum Erlangen, Department of Dermatology, Erlangen, Germany, 2Cancer Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia,
3
Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Dept. Internal Medicine III, Mainz, Germany.
1
P.A.17.15
The use of a Transgenic Rodent Malaria Challenge Model for Assessment of Novel Liver-Stage Malaria Vaccines
A. M. Salman1,2, R. J. Longley1, A. J. Spencer1, S. M. Khan2, C. J. Janse2, A. V. Hill1;
The Jenner Institute, University of Oxford, Oxford, United Kingdom, 2Leiden Malaria Research Group (LMRG), LUMC, Leiden University, Leiden, Netherlands.
1
Tuesday
P.A.17.16
Enhancement of CD8+ T-cell memory by removal of a vaccinia virus NF-κB inhibitor
P.A.17.17
S100A8/A9 proteins act as amplifiers of RANK-RANKL-mediated anti-viral immunity during cutaneous Herpes simplex infection
P.A.17.18
Dynamics of KLRG1 and IL-7Rα expression on virus-specific CD8 T cells during primary hCMV and EBV infection
P.A.17.19
DNA prime/MVTT boost enhances immune response against mosaic HIV-1 Gag antigen by engaging innate immunity in vivo
P.A.17.20
Gene expression signatures of spleen-memory-CD8 T lymphocytes reveal migration and epitope-spreading as two essential properties associated with protection
P.A.17.21
Plasmacytoid dendritic cell survival during acute sterile inflammation is controlled by the CD8 T cell-dependent perforin pathway
H. Ren, B. J. Ferguson, C. M. de Motes, R. P. Sumner, L. Harman, G. L. Smith;
Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
L. Klenner1, W. Hafezi2, T. Vogl3, N. Sucker1, C. Baumann1, K. Holz1, M. Schneeweiß1, T. Luger1, J. Roth3, J. Kühn2, K. Loser1;
1
Department of Dermatology, University of Münster, Münster, Germany, 2Department of Medical Microbiology, University of Münster, Münster, Germany, 3Department of Immunology, University of
Münster, Münster, Germany.
E. B. M. Remmerswaal1, M. C. van Aalderen1, H. Pircher2, I. J. ten Berge1, R. A. van Lier3;
1
AMC, Amsterdam, Netherlands, 2University of Freiburg, Freiburg, Germany, 3Sanquin, Amsterdam, Netherlands.
W. Liu, Z. Chen;
AIDS institution, HKU Li Ka Shing Faculty of Medicine, hk, Hong Kong.
J. Marvel1, L. Brinza1, S. Djeballi1, M. Tomkowiak1, J. Mafille1, C. Loiseau1, P. Jouve2, S. de Bernard2, Y. Leverrier1;
1
CIRI-Inserm-ENS de lyon, Lyon, France, 2Altrabio, Lyon, France.
A. Mossu, A. Daoui, F. Bonnefoy, P. Saas, S. Perruche;
INSERM UMR1098, EFS BFC, Besançon, France.
Chairpersons: Stephanie Graff-Dubois; Paris, France / Rushad Pavri; Vienna, Austria
P.A.18.01 Investigation of the Effects of Cigarette Smoke on Immunoglobulin Levels in Smokers, Non-Smokers and B cell differentiation
N. Tarbiah, P. Tighe, L. Fairclough, I. Todd;
The University of Nottingham, Nottingham, United Kingdom.
P.A.18.02 High-resolution description of post-vaccination B cell dynamics and identification of vaccine-specific sequences
J. D. Galson1, J. Trück1, A. Fowler2, E. A. Clutterbuck1, R. Van Der Most3, G. Lunter2, A. J. Pollard1, D. F. Kelly1;
1
Oxford Vaccine Group, University of Oxford, Oxford, United Kingdom, 2Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, 3GlaxoSmithKline Vaccines, Rixensart,
Belgium.
P.A.18.03
Dynamics in B cell subset and B cell repertoire distribution during human aging
A. F. Muggen, M. M. de Jong, I. L. Wolvers-Tettero, M. J. Kallemeijn, J. A. Verhaar, J. J. van Dongen, A. W. Langerak;
Erasmus Medical Center, Rotterdam, Netherlands.
P.A.18.04 Repertoires of acute phase plasmablasts and convalescent phase memory B cells after viral infection are unrelated
R. Appanna1, S. Kg1, M. Xu1, Y. Toh1, S. Velumani1, F. Zolezzi1, D. Dunn-Walters2, C. Wang1, D. Kipling3, K. Fink1;
1
Singpore Immunology Network, A*STAR, Singapore, Singapore, 2King’s College London, London, United Kingdom, 3Cardiff University, Cardiff, United Kingdom.
P.A.18.05 Differential BAFF-receptor signaling in naive, marignal zone and switched memory B cells
C. R. Smulski1, N. Wingert1, P. Kury1, D. Istanbullu1, T. M. Schleyer1, N. Mayer1, M. Speletas2, V. Lougaris3, A. Plebani3, P. Schneider4, H. Eibel1;
1
University Medical Center Freiburg, Freiburg, Germany, 2University of Thessaly, Larissa, Greenland, 3University of Brescia, Brescia, Italy, 4University of Lausanne, Lausanne, Switzerland.
P.A.18.07 Distinct metabolic remodeling in human B cell subsets following TLR9 stimulation
G. Bantug, S. Wiedemann, C. Kunz, K. Wagner, C. Hess;
Univ. Hospital Basel, Basel, Switzerland.
P.A.18.08 The microRNA processing subunit DGCR8 is required for immune response and germinal center formation
P. Daum, J. Cortê-Real, J. Schmid, K. Pracht, J. Wittmann, H. Jäck;
Division of Molecular Immunology, Department of Internal Medicine III, University of Erlangen-Nuremberg, Erlangen, Germany.
P.A.18.09 Evidence for targeting of CD38 mRNA by the post-transcriptional regulator protein ZFP36L1
A. Alcaraz1, J. D. Norton2, J. J. Murphy1;
1
Department of Biomedical Sciences, University of Westminster, London, United Kingdom, 2Department of Biological Sciences, University of Essex, Colchester, United Kingdom.
P.A.18.10 Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation
G. J. Fiala1,2,3, E. Hobeika4, F. Cesca5, M. Reth1,2,4, T. Brummer2,6, W. W. Schamel1,2,7, S. Minguet1,2;
1
Universtity of Freiburg, Freiburg, Germany, 2BIOSS - Centre for Biological Signalling Studies, Freiburg, Germany, 3Spemann Graduate School of Biology and Medicine (SGBM), Freiburg, Germany, 4Max
Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany, 5Istituto Italiano di Tecnologia, Geneva, Italy, 6Institute of Molecular Medicine and Cell Research and Comprehensive Cancer Centre,
Freiburg, Germany, 7Centre of Chronic Immunodeficiency (CCI), Freiburg, Germany.
P.A.18.11
Characterization of B-cell subsets in follicular structures: from classical germinal centers to ectopic follicles at tumor site
F. Mungenast1, A. Meshcheryakova1, A. Oswald1, E. Bajna1, D. Tamandl2, O. Koperek3, P. Birner3, D. Mechtcheriakova1;
1
Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Department of Radiology and Nuclear
Medicine, Medical University of Vienna, Vienna, Austria, 3Division of Clinical Pathology, Department of Pathology, Medical University of Vienna, Vienna, Austria.
P.A.18.12 B-cell Activating Factor (BAFF) binding receptors (BBR) on B cells: characterization in patients with rheumatoid arthritis receiving biological therapies: anti-TNF,
anti-IL6R and anti-CTLA4: a longitudinal study
D. Hernández-Flórez1, L. Valor1, A. Gallego2, E. Chamizo2, T. del Rio1, I. de la Torre1, M. Salvat1, C. González1, I. Monteagudo1, E. Naredo1, L. Carreño1;
1
Hospital General Universitario Gregorio Marañón, Madrid, Spain, 2Hospital Clínico, Merida, Spain.
P.A.18.13
Evaluating the effect of belimumab on clinical disease activity and B-cell in patients with systemic lupus erythematosus
L. Valor, D. Hernández-Flórez, J. Ovalles, J. Martínez, J. Nieto, T. del Río, C. Gonzalez, J. Lopez-Longo, I. Monteagudo, E. Naredo, L. Carreño;
Hospital General Universitario Gregorio Marañón, Madrid, Spain.
P.A.18.14 Quantification of genetic and environmental selection factors that shape B-cell repertoires
U. Menzel1, V. Greiff1, R. Riedel2, S. Reddy1;
1
ETH Zürich, Basel, Switzerland, 2DRFZ, Berlin, Germany.
P.A.18.15
Proximity screening for the BCR interactome
L. Awoniyi, E. Kuokkanen, P. Mattila;
Institute of Biomedicine, University of Turku, Turku, Finland.
P.A.18.16 The ontogeny, differentiation and function of human mature CD5+ B cells
M. Przekopowitz1, S. Taudien1, A. Görgens2, C. C. Oakes3, P. Rusch4, P. Kern4, B. Giebel2, C. Plass3, R. Küppers1, M. Seifert1;
1
Institute of Cell Biology, University Hospital Essen, Essen, Germany, 2Institute of Transfusion Medicine, University Hospital Essen, Essen, Germany, 3Division of Epigenomics and Cancer Risk Factors, DKFZ,
Heidelberg, Germany, 4Clinic for Obstetrics and Gynecology, University Hospital Essen, Essen, Germany.
52
P.A.19 Antibody Engineering and B Cell Effector Molecules
Chairpersons: Tchavdar Vassilev; Sofia, Bulgaria / Gertrude Achatz-Straussberger; Salzburg, Austria
P.A.19.01 Preparation of monoclonal antibody against carcinoembryonic antigen Glypican-3 and its preliminary application
Y. Wang;
Tianjin First Center Hospital, Tianjin, China.
P.A.19.02
Sensitivity of therapeutic antibodies to redox microenvironment: mechanism and relevance for therapy
P.A.19.03
Production of Anti-CD14 Monoclonal Antibody Using Synthetic Peptide of Human CD14 as Immunizing Antigen
A. Jarossay1,2,3, L. Gilardin1,2,3, S. Kaveri1,2,3, S. Lacroix-Desmazes1,2,3, J. D. Dimitrov1,2,3;
1
Centre de Recherche des Cordeliers, Paris, France, 2Université Pierre et Marie Curie, Paris, France, 3Université Paris Descartes, Paris, France.
L. Mohamed Khosroshahi, B. Baradaran, L. Aghebati Maleki;
Immunology, Tabriz, Iran, Islamic Republic of.
P.A.19.04 Production and characterization of mouse monoclonal antibody against human IgA
J. Majidi, l. Aghebati Maleki;
Immunology Research Center, Tabriz, Iran, Islamic Republic of.
P.A.19.05 Development and characterization of monoclonal antibodies against leukocyte common antigen
L. Aghebati Maleki, J. Majidi;
Immunology Research Center, Tabriz, Iran, Islamic Republic of.
M. Yousefi1, V. Younesi2, F. Jadidi-Niaragh1, R. Khosravi-Eghbal2, F. Shokri2;
1
Tabriz University of Medical Scinces, Tabriz, Iran, Islamic Republic of, 2Tehran University of Medical Scinces, Tehran, Iran, Islamic Republic of.
P.A.19.07 Engineering single domain antibodies (Nanobodies) as potent antagonists of lymphocyte ecto-enzymes, ion channels, and bacterial toxins
F. Koch-Nolte, A. Eichhoff, T. Eden, K. Schütze, S. Menzel, B. Rissiek, F. Haag;
University Medical Center Hamburg, Hamburg, Germany.
P.A.19.08 Construction and characterization of anti tetanus toxin single-chain Fvs from human immune phage library
M. Seifi-Najmi1, S. Sadreddini1, S. Sadreddini1, F. Jadidi-Niaragh1, V. Younesi2, M. Yousefi1,3;
1
Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of, 2Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 3Immunology research center, Tabriz, Iran, Islamic Republic
of.
Tuesday
P.A.19.06 Comparative Human and Mouse Antibody Responses Against Tetanus Toxin at Clonal Level
P.A.19.09 IVIg with additionally enhanced polyspecificity improves survival in experimental sepsis and aseptic SIRS
I. Djoumerska-Alexieva1, L. Roumenina2, A. Pashov1, J. Dimitrov2, M. Hadzhieva1, S. v. Gunten3, S. Kaveri2, J. Cavaillon4, T. Vassilev1;
1
Stefan Angelov Institute of Microbiology, Sofia, Bulgaria, 2INSERM UMRS 1138, Centre de recherche des Cordeliers, Paris, France, 3University of Bern, Bern, Switzerland, 4Institut Pasteur, Paris, France.
P.A.19.10 Unconventional class I myosins regulate B cell immunological-related functions
J. L. Maravillas-Montero1,2, O. López-Ortega2,1, L. Santos-Argumedo2;
1
Universidad Nacional Autónoma de México, Mexico City, Mexico, 2CINVESTAV, Mexico City, Mexico.
P.A.19.11
Acidic phospholipids govern the burst-enhanced activation of IgG-B cell receptor
P.A.19.12
An efficient method for EBV immortalization of human memory B lymphocytes isolated by FACS and MACS methods
P.A.19.13
Role of the adapter protein Grb2 in canonical B cell receptor signaling
P.A.19.15
Localization and functional implication of synaptobrevins in human antibody secreting cells
W. Liu1, X. Chen1, W. Pan2, C. Xu2;
1
Tsinghua University, Beijing, China, 2Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
S. Sadreddini1, S. Sadreddini1, M. Seifi-Najmi1, F. Jadidi-Niaragh1, V. Younesi2, M. Yousefi1,3;
1
Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of, 2Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 3Immunology research center, Tabriz, Iran, Islamic Republic
of.
C. Bartsch, C. Hitzing, J. Lutz, W. Schulze, J. Wienands, N. Engels;
Institute for Cellular and Molecular Immunology, Goettingen, Germany.
L. Gómez-Jaramillo, R. Romero-García, F. Mora-López, G. Jiménez-Gómez, A. Ramos-Amaya, J. A. Brieva, A. Campos-Caro;
Hospital Universitario Puerta del Mar, Cádiz, Spain.
P.A.19.16 Investigating the pharmacokinetics and therapeutic potential of PEPITEM: a novel peptide inhibitor of T cell transmigration
B. Apta, M. Chimen, M. Harrison, H. M. McGettrick, P. Narendran, P. F. Lalor, G. E. Rainger;
P.A.19.17
Screening and identification of anti-HLA antibodies by ELISA and Luminex® in Moroccan patients’ assessment of renal transplantation
G. Saadane1,2, M. Oudghiri1, S. Bennani2, A. Naya1, N. Mdaghri2;
1
Hassan II University, Casablanca, Morocco, 2Pasteur institute of Morocco, Casablanca, Morocco.
P.A.19.19 Type I interferon production by B cells controls the balance between immunopathology and pathogen burden in lungs during Mycobacterium tuberculosis
infection
A. Bénard1, I. Sakwa2, P. Schierloh3, I. Mercier1, L. Jouneau4, P. Boudinot4, L. Tailleux5, T. Al-Saati6, R. Lang7, J. Rehwinkel8, S. Kaufmann9, V. Anton-Le Berre10, A. O’Garra11, B. Gicquel5, M. Sasiain3, S.
Fillatreau2, O. Neyrolles1, D. Hudrisier1;
1
IPBS, CNRS & Université de Toulouse, Toulouse, France, 2DRFZ, Berlin, Germany, 3IMEX CONICET- Academia Nacional de Medicina, Buenos Aires, Argentina, 4INRA, Jouy-en-Josas, France, 5Institut Pasteur,
Paris, France, 6INSERM, Toulouse, France, 7ICMIH, University Hospital, Erlangen, Germany, 8MRC Human Immunology Unit, Oxford, United Kingdom, 9MPIIB, Berlin, Germany, 10INSA, UPS, INP, LISBP,
Toulouse, France, 11MRC NIMR, London, United Kingdom.
P.A.19.20
Bi-polar distribution of IgG1 levels to Staphylococcus aureus observed in the general population
P.A.19.21
Neutralization hierarchy, V gene-restriction and limits to viral drift in the antibody response to the globular head of pandemic H1N1 HA
J. Whitehouse1, Y. Yamaguchi1, A. Flaxman1, C. Rollier2, M. K. O’Shea3,1, J. Fallowfield4, M. Lindsay4, F. Gunner4, K. Knox5, D. H. Wyllie1,6;
1
Jenner Institute, University of Oxford, Oxford, United Kingdom, 2Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom, 3Department of Academic Medicine, Royal
Centre for Defence Medicine, Birmingham, United Kingdom, 4Environmental Medicine and Science Division, Institute of Naval Medicine, Gosport, United Kingdom, 5Nuffield Department of Primary Care
Health Sciences, Oxford, United Kingdom, 6Nuffield Department of Medicine, Department of Microbiology, John Radcliffe Hospital, Oxford, United Kingdom.
A. Frühwirth1,2, M. Foglierini Perez1, E. Ketelaars1, B. Maria Fernandez Rodriguez1, K. Pieper1, S. Jovic1, C. Silacci1, S. Barbieri1, D. Corti1, A. Lanzavecchia1,2;
IRB Bellinzona, Bellinzona, Switzerland, 2Institute of Microbiology, ETH Zürich, Zürich, Switzerland.
1
Chairpersons: Mala Maini; London, United Kingdom / Rene van Lier; Amsterdam, Netherlands
P.B.15.01
Innate immune profiling of uninfected Irish women with iatrogenic exposure to hepatitis C virus
P.B.15.02
Are HLA and killer cell immunoglobulin-like receptors relevant for the course of HBV infection?
P.B.15.03
Lack of Fas/FasL signalling leads to dysregulation of innate and adaptive immune response during HSV-2 vaginal infection in mice
M. W. Robinson1, C. Keane1, M. Needham1, G. Roche1, C. Gardiner1, D. Houlihan2, C. O’Farrelly1,3;
1
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland, 2Liver Unit, St. Vincent’s University Hospital, Dublin, Ireland, 3School of Medicine, Trinity Biomedical Sciences
Institute, Dublin, Ireland.
A. Georgieva1, V. Varbanova2, M. Ivanova1, D. Petrova1, A. Mihaylova1, E. J. Naumova1;
1
University Hospital Alexandrovska, Medical University, Sofia, Bulgaria, 2Specialized Hospital for Active Treatment of Hematological Diseases, Sofia, Bulgaria.
P. Orlowski, M. Krzyzowska;
Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
53
P.B.15.04
Polymorphism of ATG16L1 gene associated with chronic hepatitis B virus infection in Thais
P.B.15.05
Human amniotic fluid contains neutralizing antibodies that protect the neonate from respiratory syncytial virus infection
I. Kimkong;
Kasetsart University, Bangkok, Thailand.
S. R. Jacobino1, M. Nederend1, M. Hennus1,2, M. L. Houben2, J. O. Ngwuta3, M. Viveen4, F. E. Coenjaerts4, C. E. Hack1, R. J. van Neerven5, B. S. Graham3, L. Bont1,2, J. H. Leusen1;
Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands, 2Department of Pediatrics, Wilhelmina Children’s Hospital, Utrecht, Netherlands, 3Viral Pathogenesis Laboratory, National
Institute of Allergy and Infectious Diseases, Bethesda, MD, United States, 4Medical Microbiology, UMC Utrecht, Utrecht, Netherlands, 5Cell Biology and Immunology, Wageningen University, Wageningen,
Netherlands.
1
Tuesday
P.B.15.06
Determination of human papillomavirus (HPV) genotypes and viral load in urogenital papillomavirus infections in women
P.B.15.07
Mck2-dependent infection of alveolar macrophages promotes replication of MCMV in nodular inflammatory foci of the neonatal lung
P.B.15.08
Cross-species infectivity of H3N8 influenza virus in swine
P.B.15.10
Expression and purification of a folded recombinant surface protein subunit F2 of human respiratory syncytial virus (HRSV)
P.B.15.11
Immunopathology in a new model of haemorrhagic fever caused by hantavirus infection
P.B.15.12
The role of macroautophagy in the immune response against Influenza A infection
P.B.15.13
Focused antibody response to influenza linked to antigenic drift
L. V. Solomatina1,2, N. P. Evstigneeva3, Y. N. Kuznetsova3, N. V. Zilberberg3, N. A. Gerasimova3, N. A. Balbert3;
1
Ural Federal University Named After the First President of Russia B. N. Yeltsin, Ekaterinburg, Russian Federation, 2Institute of Immunology and Physiology, Ural Branch of the RAS, Ekaterinburg, Russian
Federation, 3Federal state institution “Ural scientific research Institute of dermatovenerology and immunopathology” of the Ministry of health of the Russian Federation, Ekaterinburg, Russian Federation.
F. Stahl1,2, K. A. Keyser3, K. Heller2, Y. Bischoff2, S. Halle2, K. Wagner3, M. Messerle3, R. Förster2;
1
University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Hannover Medical School, Institute of Immunology, Hannover, Germany, 3Hannover Medical School, Institute of Virology, Hannover,
Germany.
A. Solorzano1, E. Foni2, L. Cordoba3, M. Baratelli3, E. Razzuoli4, D. Bilato5, M. Martin del Burgo6, D. Perlin1, J. Martinez3,7, P. Martinez-Orellana3, L. Fraile8, C. Chiapponi2, M. Amadori5, G. del Real6, M.
Montoya9,3;
1
Public Health Research Institute and Regional Biocontainment Laboratory, Rutgers, The State University of New Jersey, Newark, NJ, United States, 2OIE Reference Laboratory for Swine influenza, Istituto
Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna, Parma, Italy, 3Centre de Recerca en Sanitat Animal (CReSA) - Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Campus UAB,
Barcelona, Spain, 4S.S. Genova, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Genoa, Italy, 5Laboratory of Cellular Immunology, Istituto Zooprofilattico Sperimentale della
Lombardia e dell’Emilia-Romagna, Brescia, Italy, 6Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain, 7Departament de Sanitat i
Anatomia Animals, Universitat Autònoma Barcelona, 08193, Bellaterra, Barcelona, Spain, 8Universitat de Lleida, Lleida, Spain, 9The Pirbright Institute, Pirbright, Surrey, United Kingdom.
K. Borochova, K. Niespodziana, M. Focke-Tejkl, R. Valenta;
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
M. Raftery, L. Kobak, G. Schönrich;
Institut für Virologie, Berlin, Germany.
P. Paul1, M. Loi1, M. Gannagé2, C. Münz1;
1
University of Zurich, Zurich, Switzerland, 2University of Geneva, Geneva, Switzerland.
K. Huang1, P. Rijal2, L. Schimanski2, T. J. Powell2, T. Lin3, J. McCauley4, R. Daniels4, A. R. Townsend2;
Division of Pediatric Infectious Diseases, Taoyuan, Taiwan, 2University of Oxford, Oxford, United Kingdom, 3Chang Gung University, Taoyuan, Taiwan, 4Crick Worldwide Influenza Centre, London, United
Kingdom.
1
P.B.15.14
Role of N6-methyladenosine in viral pathogenicity
P.B.15.15
Role of single-nucleotide polymorphisms in the susceptibility and severity of influenza virus infection
P.B.15.16
Highly pathogenic avian influenza virus (H5N1) causes severe symptoms due to insufficient induction of humoral immune responses
P.B.15.17
Persistent intrahepatic Vγ9Vδ2 T-cells impairment in HCV-infected patients
V. Laukemper1, A. Kaufmann1, M. Matrosovich2, S. Bauer1;
1
Institut für Immunologie, Marburg, Germany, 2Institut für Virologie, Marburg, Germany.
M. López-Rodríguez1, J. Solé-Violán2, E. Herrera-Ramos1, J. Ruiz-Hernández3, N. González-Quevedo1, Y. Florido1, T. Rodríguez4, L. Borderías5, J. Horcajada6, J. Blanquer7, J. Ferrer2, O. Rajas8, J. Aspa8, F.
Rodríguez de Castro9,10, C. Rodríguez-Gallego11;
1
Immunology Department, Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain, 2Intensive Care Unit, Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran
Canaria, Spain, 3Internal Medicine Department, Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain, 4Biochemistry Department, Hospital Universitario de Gran Canaria Dr
Negrín, Las Palmas de Gran Canaria, Spain, 5Department of Respiratory Diseases, Hospital San Jorge, Huesca, Spain, 6Department of Infectious Diseases, Hospital Universitari del Mar, Barcelona, Spain,
7
Intensive Care Unit, Hospital Clínico y Universitario de Valencia, Valencia, Spain, 8Department of Respiratory Diseases, Hospital Universitario de la Princesa, Madrid, Spain, 9Department of Respiratory
Diseases, Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain, 10Department of Medical and Surgical Sciences, School of Medicine, University of Las Palmas de Gran
Canaria, Las Palmas de Gran Canaria, Spain, 11Immunology Department, Hospital Universitario Son Espases, Palma de Mallorca, Spain.
A. Ikejiri1, F. Yasui1, Y. Itoh2, N. Sakaguchi1,3, K. Ogasawara2, M. Kohara1;
1
Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan, 2Division of Pathology and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Shiga, Japan,
3
Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan.
C. Agrati1, E. Cimini2, V. Bordoni2, U. Visco - Comandini2, M. Montalbano2, R. Lionetti2, A. Sacchi2, R. Casetti2, N. Tumino2, G. D’Offizi2, M. Capobianchi2, F. Martini2;
1
Inmi l Spallanzani, Rome, Italy, 2Inmi L Spallanzani, Rome, Italy.
P.B.16 Immunity to Bacterial Infection and Parasites
Chairpersons: Anca Dorhoi; Berlin, Germany / Dunja Bruder; Braunschweig, Germany
P.B.16.01
Analysis of the virulence and immunogenicity of porcine and human M. avium ssp. hominissuis isolates in an experimental mouse model
P.B.16.02
Evaluation of the endocrine changes during tuberculosis treatment
P.B.16.03
Immunosuppressive properties by IL-10 and regulatory T cells in nontuberculous mycobacterial lung disease
N. Bruffaerts1, C. Vluggen1, L. Duytschaever2, J. Denoël3, R. Wattiez4, J. Letesson5, V. Roupie2, V. Mathys1, D. Fretin2, C. Saegerman3, K. Huygen1;
1
Scientific Institute of Public Health, Brussels, Belgium, 2CODA-CERVA, Brussels, Belgium, 3Liège University, Liège, Belgium, 4UMons, Mons, Belgium, 5FUNDP, Namur, Belgium.
L. Kleynhans, S. Ruzive, P. D. van Helden, G. Walzl, K. Ronacher;
Stellenbosch University, Cape Town, South Africa.
M. Jung1, S. Kang2, E. Shin1;
1
Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea, Republic of, 2Department of Internal Medicine, Gachon University Gil
Hospital, Incheon, Korea, Republic of.
P.B.16.04 Dectin-1/CARD9 single nucleotide polymorphisms and susceptibility to pulmonary tuberculosis
J. Irure Ventura, A. R. Guerra, E. Asensio, F. Ausín, J. Arroyo, R. Agüero, M. Fariñas, J. Ocejo-Vinyals;
Hospital Universitario Marqués de Valdecilla, Santander, Spain.
P.B.16.05
TNF dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis
N. Francisco1, N. Hsu1, R. Keeton1, P. Randall1, B. Sebesho1, N. Allie1, D. Govender1, V. Quesniaux2, B. Ryffel2, L. Kellaway1, M. Jacobs1;
1
University of Cape Town, Cape Town, South Africa, 2CNRS, Orleans, France.
P.B.16.06 A novel strategy for the detection of active tuberculosis
A. Asbach-Nitzsche1, S. Barabas1, K. Drexler1, M. Fleck2, K. Avsar3, K. Böckl1, M. Reuter4, J. Köstler5, S. Blaas6, L. Deml1;
Lophius Biosciences GmbH, Regensburg, Germany, 2Asklepios Klinik Bad Abbach Klinik für Rheumatologie, Bad Abbach, Germany, 3Asklepios Fachkliniken München-Gauting, Gauting, Germany, 4Praxis
Reuter, Regensburg, Germany, 5Institut für Mikrobiologie und Hygiene Universitätsklinikum Regensburg, Regensburg, Germany, 6Klinik Donaustauf Zentrum für Pneumologie, Donaustauf, Germany.
1
P.B.16.07
Experimental BCG vaccination induces preeminent CD4 T-cell responses to lipopeptide antigens unique for the mycobacterium tuberculosis complex
E. Kaufmann1, C. Spohr1, S. Battenfeld1, E. Balks1, N. Reiling2, M. Gilleron3, M. Bastian1;
1
Paul-Ehrlich-Institut, Langen, Germany, 2Forschungszentrum Borstel, Borstel, Germany, 3CNRS, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France.
P.B.16.08 Immunological profiling of tuberculosis patients reveals their great variability
A. V. Panteleev, I. Y. Nikitina, G. A. Kosmiadi, I. A. Vasilieva, I. V. Lyadova;
Central Tuberculosis Research Institute, Moscow, Russian Federation.
P.B.16.09 Primary human airway epithelial cells are early responders to tuberculosis infection
A. Reuschl, M. Edwards, D. Connell, S. Bremang, O. Kon, R. Shattock, A. Lalvani;
Imperial College London, London, United Kingdom.
54
P.B.16.10
Early Secreted Antigenic Target 6 kDa Protein of Mycobacterium tuberculosis Stimulates Macrophage Production of Monocyte Chemotactic Protein 1 and Its
Regulation by p38 MAPK and Interleukin-4
J. Ma, B. Jung, N. Yi, B. Samten;
University of Texas Health Science Center at Tyler, Tyler, TX, United States.
P.B.16.12
ESX-1-mediated type I interferon-signaling promotes a regulatory macrophage phenotype refractory to IFNγ-mediated killing of intracellular mycobacteria
P.B.16.13
Platelets and the regulation of matrix metalloproteinase secretion in tuberculosis
P.B.16.14
TNF-mediated restriction of arginase 1 expression in myeloid cells contributes to the control of Leishmania major infections
P.B.16.15
Molecular characterization and antigenic properties of a novel Babesia gibsoni glutamic acid-rich protein (BgGARP)
J. Lienard, E. Movert, C. Valfridsson, E. Sturegård, F. Carlsson;
Lund University, Lund, Sweden.
K. Fox, B. Mistry, J. Friedland;
Imperial College of London, London, United Kingdom.
U. Schleicher1, K. Paduch1, A. Debus1, P. J. Murray2, H. Körner3, C. Bogdan1;
1
Mikrobiologisches Institut – Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany,
2
Departments of Infectious Diseases and Immunology, St. Jude Children’s Research Hospital, Memphis, TN, United States, 3Menzies Institute for Medical Research Tasmania, Hobart, Australia.
S. S. Elballal1, X. Xuan2, A. Mousa1, M. Attia1, S. Abd El Aziz3;
1
Faculty of veterinary medicine/University of Sadat city, Sadat city, Egypt, 2National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido,
Obihiro, Japan, 3Faculty of veterinary medicine/Cairo university, Giza, Egypt.
J. Tosello Boari1, C. Araujo1, F. Fiocca1, M. C. Ramello1, M. C. Amezcua1, M. Gorosito1, N. Nuñez2, N. Cagnard3, E. Piaggio2, C. Montes1, A. Gruppi1, E. Acosta Rodriguez1;
1
School of Chemistry, National University of Cordoba (FCQ-UNC), Córdoba, Argentina, 2INSERM U932, Institut Curie, Paris, France, 3Plateforme Bio-informatique Paris Descartes, Paris, France.
P.B.16.17
Enhanced presence of anergic/exhausted CD8+ T-cells contributes towards sustaining Indian Post Kala-azar Dermal Leishmaniasis
S. Mukherjee1, D. Mukhopadhyay1, C. Braun2, S. Mitra1, N. k. Das3, U. Chatterjee1, E. vonStebut2, M. Chatterjee1;
Institute of Post Graduate Medical Education & Research, Kolkata, India, 2Johannes Gutenberg University, Mainz, Germany, 3Calcutta Medical College, Kolkata, India.
1
P.B.16.18 Guanylate binding proteins (GBPs) act as supramolecular complexes in T. gondii defense
E. Kravets1, D. Degrandi1, Q. Ma2, S. Felekyan2, T. Peulen2, S. Weidtkamp-Peters3, C. Seidel2, K. Pfeffer1;
1
Institute of Medical Microbiology and Hospital Hygiene, Düsseldorf, Germany, 2Chairpersons: for Molecular Physical Chemistry, Düsseldorf, Germany, 3Center for Advanced Imaging, Düsseldorf, Germany.
Tuesday
P.B.16.16 T cell-intrinsic IL-17RA-signaling modulates CD8+ T cell differentiation and exhaustion during Trypanosoma cruzi infection
P.B.16.19 Method of a flow cytometry in an assessment of subpopulations of immunocompetent cells of patients at tuberculosis
O. V. Berdugina, A. V. Ershova;
Ural Research Institute of Phthisiopulmonology, Yekaterinburg, Russian Federation.
P.B.16.20
Studying of cells of immunity and fagotcytosis at patients from tuberkulema
P.B.16.21
P2x7 receptor expression on hematopoietic cells contributes to severe tuberculosis
C. Barbosa Bomfim, E. Amaral, A. Cassado, R. Nascimento, M. Hirata, J. Alvarez, M. D’Império Lima;
University of São Paulo, São Paulo, Brazil.
P.B.17 Immunity to Parasite Infection
Chairpersons: Adrian Hill; Oxford, United Kingdom / Thomas Jacobs; Hamburg, Germany
P.B.17.01
Multiplex chemokine profile in chronic Chagas disease cardiomyopathy: a strong Th1-mediated response possibly associated with pathological myocardial
remodeling
G. R. Sousa1, J. A. Gomes1, M. P. Damásio1, H. S. Costa1, M. C. Nunes1, N. I. Medeiros2, A. C. Souza1, R. G. Fares2, R. Corrêa-Oliveira2, M. O. Rocha1;
Universidade Federal e Minas Gerais, Belo Horizonte, Brazil, 2Centro de Pesquisa Rene Rachou, Belo Horizonte, Brazil.
1
P.B.17.02
Does Chagas cardiomyopathy have more intense inflammatory response than idiopathic dilated cardiomyopathy?
P.B.17.03
Changes in circulating cytokine levels after meglumine antimoniate treatment of cutaneous leishmaniasis
P.B.17.04
Strategy to assess the overall cytokine profile and its association with severity of human Chagas disease
P.B.17.05
Galectin-1 subverts immunity by fostering immunoregulatory mechanisms during a trypanosomatid infection
P.B.17.06
Unraveling the role of IL-17A in the intestinal immune response against the protozoan parasite Giardia muris by an RNA sequencing approach
P.B.17.07
Lack of IL-22 induces an increased immune response during malaria infection in mice
P.B.17.08
Apoptotic-like Leishmania exploit the host’s autophagy machinery to reduce T-cell-mediated parasite elimination
P.B.17.09
Immunomodulatory activity of leishmania kinetoplast associated DNA
G. R. Sousa, H. S. Costa, A. C. Souza, A. L. Teixeira, M. O. Costa Rocha, M. C. Pereira Nunes;
Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
M. M. Albuquerque1, A. B. Sousa1, F. R. Santos1, A. T. Vieira1, K. D. Amorim1, J. R. Souza1,2, C. B. Madruga3, G. S. Meireles3, A. I. Fernandes1,3, L. R. Castellano1;
1
Human Immunology Research and Education Group, Escola Técnica de Saúde da UFPB, Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil, João Pessoa Paraíba, Brazil, 2Department of
Physiology and Pathology, Center for Health Sciences, Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil, João Pessoa Paraíba, Brazil, 3Division of Infectious Diseases, Hospital Universitário
Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil, João Pessoa Paraíba, Brazil.
G. R. Sousa1, J. A. Gomes1, M. P. Damásio1, H. S. Costa1, M. C. Nunes1, N. I. Medeiros2, A. C. Souza1, K. S. Ferreira1, R. Correa-Oliveira2, M. O. Rocha1;
1
Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, 2Centro de Pesquisa Rene Rachou, Belo Horizonte, Brazil.
C. V. Poncini1, J. M. Ilarregui2, E. Batalla1, M. Cucher1, Y. van Kooyk2, J. P. Cerliani3, S. González Cappa1, G. Rabinovich3;
1
Departamento de Microbiología, Parasitología e Inmunología, Fac. Medicina, Ciudad Autónoma de Buenos Aires, Argentina, 2Department of Molecular Cell Biology and Immunology, VU University Medical
Center, Amsterdam, Netherlands, 3Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Ciudad Autónoma de Buenos Aires, Argentina.
O. Paerewijck1, L. Dreesen1, F. Van Meulder1, D. Ratman2, K. De Bosscher2, R. W. Li3, P. Geldhof1;
1
Department of Virology, Parasitology and Immunology, Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium, 2VIB Department of Medical Protein Research,
Cytokine Receptor Lab, Nuclear Receptor Signaling Unit, Ghent University, Ghent, Belgium, 3United States Department of Agriculture, Agriculture Research Service, Animal Genomics and Improvement
Laboratory, Beltsville, MD, United States.
J. Sellau1, S. Huber2, T. Jacobs1;
1
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, 2University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
P. Crauwels1,2, R. Bohn1, M. Thomas1, S. Gottwald2, F. Jäckel2, S. Krämer1, E. Bank1, S. Tenzer3, P. Walther4, M. Bastian5, G. van Zandbergen1,2,3;
1
Paul-Ehrlich-Institute, Division of Immunology, Langen, Germany, 2Institute of Medical Microbiology and Hygiene, University Clinic Ulm, Ulm, Germany, 3Institute of Immunology, University Medical Center,
Mainz, Germany, 4Central Facility for Electron Microscopy, University of Ulm, Ulm, Germany, 5Paul-Ehrlich-Institute, Division of Veterinary Medicine, Langen, Germany.
I. C. Ayanoğlu1, C. Yangınlar1, S. Özensoy Töz2, Y. Özbel2, A. Özbilgin3, N. Girginkardeşler3, I. Gürsel4, M. Gürsel1;
Department of Biological Sciences, Middle East Technical University, Ankara, Turkey, 2Department of Medical Parasitology, School of Medicine, Ege University, İzmir, Turkey, 3Department of Medical
Parasitology, School of Medicine, Celal Bayar University, Manisa, Turkey, 4Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey.
1
P.B.17.10
Evaluation of phenotypic profile and immune response of Leishmania infantum tropism in Post-kala-azar dermal leishmaniasis (PKDL)
P.B.17.11
Prevalence of Leismaniasis in a region of Western Greece. Twenty-years study
A. K. M. Santana1, T. R. Moura1, A. M. de Jesus1, J. S. Silva2, R. P. Almeida1, V. C. Pereira2;
1
University of Sergipe, Aracaju, Brazil, 2University of São Paulo, Ribeirão Preto, Brazil.
1
P.B.17.12
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) inhibits transcription factor activation in monocytes/macrophages and modulates early
cytokine response
N. G. Sampaio1, E. M. Eriksson1, L. Schofield1,2;
1
The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, 2Australian Institute of Tropical Health and Medicine, Townsville, Australia.
55
Tuesday
P.B.17.13
Dynamic flux of microvesicles modulate parasite-host cell interaction of Trypanosoma cruzi in eukariotic cells
P.B.17.14
A single base polymorphism -3499 G/T of FOXP3 gene and CD4+CD25highFOXP3+ T cells phenotype is associated with the indeterminate form of Chagas disease
P.B.17.15
Origin of Foxp3+ regulatory T cells during Plasmodium yoelii infection in BALB/c mice
P.B.17.16
Impact of galectin-3 on the course of experimental Trypanosoma cruzi infection
P.B.17.17
The influence of Human leucocyte antigen-G (HLA-G) and its murine functional homolog Qa2 during Trypanosoma cruzi infection
P.B.17.18
Trypanosoma cruzi infection through the oral route promotes a severe infection in mice
P.B.17.19
IL-17 is associates with protection in human visceral leishmaniasis
P.B.17.20
Monocytes in Indian Visceral Leishmaniasis demonstrated an IL-10 driven polarization
P.B.17.21
PI3Kγ/AKT1 signaling in macrophages is essential for resistance against Trypanosoma cruzi infection
M. I. Ramirez1, I. Evans-Osses1, I. C. Almeida2;
1
Instituto Oswaldo Cruz, Rio de Janeiro, Brazil, 2university of texas El paso, EL paso Texas, TX, United States.
K. S. Ferreira1, R. Corrêa-Oliveira2, G. R. Sousa1, J. C. Alves1, N. S. Souza1, T. K. Lima3, M. P. Damásio1, V. A. Valente1, R. G. Fares2, A. D. Araújo1, N. I. Medeiros1, A. T. Chaves2, F. F. de Araújo2, M. O. Rocha1, J.
A. Gomes1;
1
Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, 2Centro de Pesquisa Rene Rachou, Belo Horizonte, Brazil, 3Universidade Federal do Rio Grande do Norte, Natal, Brazil.
K. Ueffing, S. Abel, R. Tatura, J. Kehrmann, A. M. Westendorf, J. Buer, W. Hansen;
UK Essen - Institute of Medical Microbiology, 45147 Essen, Germany.
D. Silva dos Santos1, J. Barreto de Albuquerque1, L. R. Berbert1, L. V. Guillermo2, D. A. Farias de Oliveira1, W. Savino1, J. de Meis1, D. M. Villa Verde1;
1
Instituto Oswaldo Cruz, Rio de Janeiro, Brazil, 2Federal University of Rio de Janeiro State, UNIRIO, Rio de Janeiro, Brazil.
F. C. Dias1, C. T. Mendes-Junior2, M. C. Silva3, F. S. Tristao4, P. Moreau5, E. G. Soares6, A. Schmidt1, R. O. Dantas1, J. A. Marin-Neto1, J. S. Silva3, E. A. Donadi1;
1
Department of Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil, 2Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto,
Universidade de São Paulo, Ribeirão Preto, Brazil, 3Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil, 4Departamento
de Morfologia, Fisiologia e Patologia Básica, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil, 5CEA, Institute of Emerging Diseases and Innovative Therapies,
Research Division in Hematology and Immunology, Paris, France, 6Departamento de Patologia e Medicina Legal, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
J. Barreto de Albuquerque1, D. Silva dos Santos1, A. R. Pérez2, L. R. Berbert1, E. de Santana van Vliet1, D. A. Farias de Oliveira1, O. Moreira1, E. Roggero2, C. E. de Carvalho Pinto3, J. Jurberg1, V. Cotta de
Almeida1, O. Bottasso2, W. Savino1, J. de Meis1;
1
Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, 2National University of Rosario, Rosario, Argentina, 3Federal Fluminense University, Niteroi, Brazil.
O. P. Singh1, N. Ansari2, R. Kumar1,3, S. Nylen4, D. Sacks2, S. Sundar1;
1
Institute of Medical Sciences, Banaras Hindu University, Varanasi, India, 2NIAID, National Institute of Health, Bethesda, MD, United States, 3National Institute of Technology, Rourkela, India, 4Karolinska
Institute, Stockholm, Sweden.
S. Roy1, D. Mukhopadhyay2, S. Mukherjee2, R. P. Goswami3, N. Pramanik3, S. K. Guha3, B. Saha3, M. Chatterjee2;
1
German Leprosy and TB Relief Association – India (GLRA-India), Kolkata, India, 2Institute of Post Graduate Medical Education and Research, Kolkata, India, 3School of Tropical Medicine, Kolkata, India.
T. M. Cunha1, M. Silva1, K. Lyroni2, T. S. Medina1, G. K. Silva1, J. C. Alves-Filho1, E. Hirsch3, F. Q. Cunha1, C. Tsatsanis2, J. S. Silva1;
1
University of Sao Paulo, Ribeirao Preto, Brazil, 2University of Crete, School of Medicine, Crete, Greece, 3University of Turin, Turin, Italy.
Chairpersons: Daniela Pende; Genova, Italy / Ellen Renner; Munich, Germany
P.B.18.01
Targeted panel re-sequencing for primary immunodeficiencies
P.B.18.02
A novel NFKB2 mutation modulates the canonical and noncanonical NFκB pathways
P.B.18.03
Lymphocyte subsets in healthy adult individuals; determination of reference values
N. Frede1, K. Huebscher1, J. Rojas1, A. Bullashevska1, B. Grimbacher1,2;
1
Center for Chronic Immunodeficiency, Freiburg, Germany, 2University College London, London, United Kingdom.
Y. Liu1,2, M. A. Ibrahim1;
1
Kings College Hospital NHS Foundation Trust, London, United Kingdom, 2Viapath, London, United Kingdom.
I. Ogulur, D. Cicekkoku, S. Baris, E. Karakoc-Aydiner, A. Ozen, I. Barlan;
Marmara University, Istanbul, Turkey.
P.B.18.04 Disease-targeted sequencing: A potent next-generation sequencing approach successfully employed to identify disease causing mutations in primary
immunodeficiencies (PIDs)
A. Krolo1, T. Hirschmugl1, I. Bilic1, B. Erman2, J. Arora1, M. Schuster1, K. Boztug1,3;
1
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, 2Department of Pediatric Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkey,
3
Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
P.B.18.05
Broad spectrum antibodies to self-antigens and cytokines in RAG deficiency
J. E. Walter1,2, L. B. Rosen3, K. Csomos1, J. M. Rosenberg4, B. Ujhazi1, K. Chen5, Y. Lee2, W. Al-Herz6, J. Puck7, S. De Ravin8, A. R. Gennery9, R. S. Abraham10, M. J. Butte11, M. Adeli12, C. Cancrini13, B. T. CostaCarvalho14, T. Niehues15, C. Schuetz16, T. Kuijpers17, R. Geha2, S. M. Holland3, M. Reche18, P. Utz19, S. K. Browne3, L. D. Notarangelo2,20;
1
Pediatric Allergy & Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2Division of
Immunology, Boston Children’s Hospital, Boston, MA, United States, 3Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, MD, United States, 4) Department Medicine, Division of Immunology
and Rheumatology, Stanford University, Stanford, CA, United States, 5Division of Allergy, Immunology & Rheumatology, Department of Pediatrics, University of Utah, Salt Lake city, UT, United States,
6
Pediatric Department, Faculty of Medicine, Kuwait University, Kuwait, Kuwait, 7Pediatric Allergy Immunology and Blood and Marrow Transplant Division, University of California, San Francisco, CA, United
States, 8Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States, 9Department of Pediatric Immunology and Institute of Cellular Medicine,
Newcastle upon Tyne Hospitals, Newcastle, United Kingdom, 10Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States, 11Department of Pediatrics, Division of
Allergy, Immunology, Rheumatology, Stanford University, Stanford, CA, United States, 12Pediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Qatar, Qatar, 13University
Department of Paediatrics, Bambino Gesù Children’s Hospital IRCCS, Rome, Italy, 14Federal University of São Paulo, São Paulo, Brazil, 15Centre for Child Health and Adolescence, Helios Klinikum Krefeld
Academic Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany, 16Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany, 17Emma Children’s Hospital,
Academic Medical Center, Amsterdam, Netherlands, 18Immunodeficiency Clinic, Medical Outpatient Unit and Immunodeficiency Lab, Department of Biomedicine, University Hospital, Basel, Switzerland,
19
Department Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA, United States, 20Harvard Stem Cell Instit
P.B.18.06 The extended clinical phenotype and the search for modifiers in patients with CTLA4 germline mutations
C. Schwab1, D. Schubert1, N. Frede1, A. Bulashevska1, M. Kanariou2, C. Speckmann1, D. Wolff3, T. Giese4, H. Lorenz4, K. Warnatz1, M. Seidl1,5, G. Dückers6, F. Emmerich7, P. Fisch5, A. Franke8, B. Grimbacher1;
1
CCI (Center for Chronic Immunodeficiency), University Medical Center Freiburg, Freiburg, Germany, 2Department of Immunology and Histocompatibility, “Aghia Sophia” Children’s Hospital, Athens, Greece,
3
Department of Transplantation, University Hospital Regensburg, Regensburg, Germany, 4Institute for Immunology and Serology, University Hospital Heidelberg, Heidelberg, Germany, 5Department of
Pathology, University Medical Center Freiburg, Freiburg, Germany, 6HELIOS Children’s Hospital Krefeld, Krefeld, Germany, 7Institute for Cell and Gene Therapy, University Medical Center Freiburg, Freiburg,
Germany, 8Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Kiel, Germany.
P.B.18.07
Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency
I. Sologuren1, M. Martínez-Saavedra1, J. Solé-Violán2, E. Betancor3, S. Zhang4, I. Casas5, J. Pestano3, E. Herrera-Ramos1, C. Pérez6, M. Ciancanelli4, M. López-Rodríguez1, N. Franco7, J. Ruiz-Hernández8, J.
Ferrer2, M. Álvarez Fernández7, J. Bustamante9,10,11, M. Martínez-Gallo12, R. Colobran13,14, J. Casanova4,15,16, C. Rodríguez-Gallego17;
1
Immunology Department. Gran Canaria Dr. Negrín University Hospital, Las Palmas de Gran Canaria, Spain, 2Intensive Care Unit. Gran Canaria Dr. Negrín University Hospital, Las Palmas de Gran
Canaria, Spain, 3Biochemistry, Molecular Biology, Physiology, Genetics and Immunology Department, School of Medicine, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain,
4
St Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY, United States, 5National Influenza Center-Madrid, National Center of Microbiology, Madrid,
Spain, 6Microbiology Department. Gran Canaria Dr. Negrín University Hospital, Las Palmas de Gran Canaria, Spain, 7Intensive Care Unit, Mostoles University Hospital, Madrid, Spain, 8Internal Medicine
Department, Gran Canaria Dr. Negrín University Hospital, Las Palmas de Gran Canaria, Spain, 9Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for
Sick Children, Paris, France, 10Paris Descartes University, Imagine Institute, Paris, France, 11Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children, AP-HP, Paris, France,
12
Immunology Department, Vall d`Hebrón University Hospital, Barcelona, Spain, 13Immunology Division, Hospital Universitari Vall d’Hebron (HUVH). Vall d’Hebron Research Institute (VHIR), Barcelona,
Spain, 14Deparment of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain, 15Laboratory of Human Genetics of Infectious Diseases, Institut National de la
Santé et de la Recherché Médicale, U980, Paris, France, 16University Paris Descartes, Necker Medical School, Paris, France, 17Immunology Department, Son Espases University Hospital, Palma de Mallorca,
Spain.
P.B.18.08 De novo inflammatory bowel disease after early cord blood hematopoietic stem cell transplant in an infant with X-linked SCID
B. Derfalvi1, J. V. Limbergen1, G. Mahdi1, M. McHenry1, A. C. Issekutz1, E. Haddad2, M. Duval2, T. B. Issekutz1;
1
Dalhousie University/IWK Health Centre, Halifax, NS, Canada, 2CHU Sainte-Justine, Montreal, QC, Canada.
P.B.18.09 Mutations in the non-homologous end-joining component XRCC4: a new PID without immunodeficiency
H. IJspeert1, J. E. Murray2, H. Kok1, A. Jackson2, G. Stewart3, L. Bicknell2, M. van der Burg1;
1
Erasmus MC, Rotterdam, Netherlands, 2University of Edinburgh, Edinburgh, United Kingdom, 3University of Birmingham, Birmingham, United Kingdom.
56
P.B.18.10
Mitogen-induced proliferative capacities of pediatric immune deficiency patients following bone marrow transplantation
P.B.18.11
Leaky RAG deficiency in adult patients with impaired antibody production against bacterial polysaccharide antigens
P.B.18.12
B-regulatory cells in CVID patients
P.B.18.13
First degree relatives of individuals with IgA deficiency are at manyfold risk of having IgA deficiency
P.B.18.14
Delayed onset of atypical IL7RA deficiency in a Tunisian patient
P.B.18.15
Screening of Slovene blood donors for severe immunoglobulin A deficiency with an in-house ELISA
U. C. Kucuksezer1, I. Tahrali1, S. Nepesov2, A. Yesilipek3, G. Deniz1, Y. Camcioglu2;
1
Istanbul University, Institute of Experimental Medicine, Dept. of Immunology, Istanbul, Turkey, 2Istanbul University, Cerrahpasa Faculty of Medicine, Dept. of Pediatrics, Istanbul, Turkey, 3Bahcesehir
University, Faculty of Medicine, Dept. of Pediatrics, Istanbul, Turkey.
C. B. Geier, K. M. Sauerwein, A. Piller, A. Linder, M. M. Eibl, H. M. Wolf;
Immunologische Tagesklinik, Wien, Austria.
M. Vlkova1, J. Nechvatalova1, O. Ticha1, J. Litzman1, T. Kalina2;
1
Department of Clinical Immunology and Allergology, St Anne’s University Hospital and Faculty of Me, Brno, Czech Republic, 2CLIP - Childhood Leukemia Investigation Prague, Department of Pediatric
Hematology and Oncology, 2nd Medical Faculty, Charles University Prague and University Hospital Motol, Prague, Czech Republic.
A. L. Lemarquis1, H. K. Einarsdóttir2, I. Jónsdóttir2,3, B. R. Ludviksson2;
1
Department of Immunology, Landspitali - The National University Hospital of Iceland,, Reykjavík, Iceland, 2Department of Immunology, Landspitali - The National University Hospital of Iceland., Reykjavík,
Iceland, 3deCODE Genetics/AMGEN, Reykjavík, Iceland.
M. Cernilec1, M. Gracar1, V. Hrasovec2, V. Galvani3, V. Curin Serbec1;
1
Department for Production of Diagnostic Reagents and Research, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia, 2Centre for Blood Donor Testing, Blood Transfusion Centre of Slovenia,
Ljubljana, Slovenia, 3Quality System Management Service, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia.
P.B.18.16 Early-onset monogenic systemic lupus erythematosus caused by deficiency of protein kinase C delta
E. Salzer1, E. Santos-Valente1, S. Klaver-Flores1,2, S. Ban1, B. Keller3, W. Emminger4, N. Serwas1, W. Garncarz1, L. Müllauer5, R. Kain5, M. G. Seidel6, W. Holter7, W. F. Pickl8, K. Bennett1, E. Förster-Waldl4, K.
Warnatz3, K. Boztug1,4;
1
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, 2Instituto de Ciências Biomédicas, São Paulo, Brazil, 3University Medical Center Freiburg Center for
Chronic Immunodeficiency Division of Rheumatology and Clinical Immunology, Freiburg, Germany, 4Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria,
5
Department of Pathology, Medical University of Vienna, Vienna, Austria, 6Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria, 7Department of Paediatrics, St.
Anna Kinderspital and Children’s Cancer Research Institute, Vienna, Austria, 8Christian Doppler Laboratory for Immunomodulation and Institute of Immunology, Center for Pathophysiology, Infectiology
and Immunology, Medical University of Vienna, Vienna, Austria.
P.B.18.17
Tuesday
A. Rais1, N. Mekki1, I. Chabchoub2, A. Safi1, B. Largueche1, M. Hachicha2, I. Ben Mustapha1, M. R. Barbouche1;
1
Institut Pasteur de Tunis, Tunis, Tunisia, 2Hedi Chaker Hospital, Sfax, Tunisia.
Revertant T cells in human CD3delta deficiency?
A. C. Briones1, A. V. Marin1, A. Jimenez-Reinoso1, B. Garcillan Goyoaga1, R. Cedeño2, E. López-Granados3, J. Gil4, O. de la Calle5, M. J. Recio1, J. R. Regueiro1;
1
Department of Immunology, Complutense University School of Medicine and Hospital 12 de Octubre Health and Reseach Institute, Madrid, Spain, 2Pediatrics, Oncologic Hospital Dr. Julio Villareces
Colmont, Portoviejo, Ecuador, 3Inmunology, University Hospital La Paz-IdiPAZ, Madrid, Spain, 4Division of Immunology, Gregorio Marañón University Hospital, Madrid, Spain, 5Inmunology, Hospital Sant
Pau-Universitat Autonoma de Barcelona, Barcelona, Spain.
P.B.18.18 Functional and molecular characterization of a novel nonsense mutation in IL2RG gene in a family with atypical presentation
M. Martinez-Gallo, R. Colobran, J. Sayos, M. García-Prat, A. Aguiló Cucurull, A. Martín-Nalda, R. Pujol-Borrell, P. Soler-Palacín;
Hospital U. Vall d’Hebron, Barcelona, Spain.
P.B.18.19 A novel heterozygous CD45 wedge mutation in a family with autoimmunity
D. J. Swan, K. R. Engelhardt, A. Grainger, D. Barge, Y. Xu, M. Santibanez Koref, A. Cant, S. Hambleton;
Newcastle University, Newcastle-upon-Tyne, United Kingdom.
P.B.18.20
ENU Mutagenesis Identifies Novel Molecular Pathomechanism of Severe Immunodeficiency
P.B.18.21
Immunological features of DiGeorge Syndrome in a cohort of 20 patients
I. Treise1,2, E. M. Huber3, T. Adler1, T. Klein-Rodewald4, C. Andres5, T. M. Strom6, T. Wieland6, K. D. McCoy7, A. J. Macpherson7, M. Ollert5, V. Gailus-Durner1, H. Fuchs1, M. Hrabě de Angelis1, M. Groll3, D. H.
Busch2;
1
Institute of Experimental Genetics, German Mouse Clinic, Munich, Germany, 2Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany, 3Center
for Integrated Protein Science at the Department Chemistry, Chairpersons: of Biochemistry, Technische Universität München, Garching, Germany, 4Institute of Pathology, Helmholtz Zentrum München,
Munich, Germany, 5Department of Dermatology and Allergy Biederstein, Technische Universität München, Munich, Germany, 6Institute for Human Genetics, Helmholtz Zentrum München, Munich,
Germany, 7University Clinic of Visceral Surgery and Medicine, Departement Klinische Forschung, University of Bern, Bern, Switzerland.
M. Jimenez Leon1,2, M. Julià Benique1,2, J. Ferrer Balaguer1,2, J. Mila LLambi1,2, J. Pons de Ves1,2, J. Iglesias Alzueta1,2, N. Martinez Pomar1,2;
Department of Immunology, Hospital Son Espases, Palma Mallorca, Spain, 2Instituto de Investigación Sanitaria de Palma (IdISPa), Palma Mallorca, Spain.
1
P.B.18.23
Accuracy of Next Generation Sequencing for the Diagnosis of Monogenetic Disorders
J. Rojas, N. Frede, K. Huebscher, A. Bullashevska, B. Grimbacher;
Center for Chronic Immunodeficiency, Freiburg, Germany.
Chairpersons: Francesco Annunziato; Florence, Italy / Denis Mulleman; Tours, France
P.B.19.01
Effect of colchicine treatment on clinical parameters and coagulation markers with respect to MEFV mutations
P.B.19.02
T cell-derived IL-9 is proinflammatory in nephrotoxic serum nephritis
P.B.19.03
Panencephalitogenic aquaporin 4-specific T cells and NMO-IgG produce large astrocyte-destructive lesions in the CNS
G. Aksu, C. Ozturk, N. Gulez, N. E. Karaca, K. Kavakli, N. Kutukculer;
Ege University Medical School, Izmir, Turkey.
A. H. Kirsch1, K. Artinger1, E. Rho2, A. M. Wolf3, I. Cornez3, P. Eller4, D. Wolf3, A. R. Rosenkranz1, K. Eller1;
1
Clinical Division of Nephrology, Medical University of Graz, Graz, Austria, 2Clinical Division of Nephrology, Medical University of Graz, 8036, Austria, 3University Hospital Bonn (UKB), Division of Oncology,
Hematology and Rheumatology, Bonn, Bonn, Germany, 4Clinical Division of Angiology, Medical University of Graz, Graz, Austria.
B. Zeka1, M. Pohl1, S. Hochmeister2, N. Kögl1, N. Kaufmann1, T. Misu3, K. Fujihara3, M. Reindl4, H. Lassmann1, M. Bradl1;
1
Medical University Vienna, Center for Brain Research, Department for Neuroimmunology, Wien, Austria, 2Medical University Graz, Department for Neurology, Graz, Austria, 3Department of Neurology,
Tohoku University Graduate School of Medicine, Sendai, Japan, 4Innsbruck Medical University, Clinical Department for Neurology, Innsbruck, Austria.
P.B.19.04 The inhibitory effect of killed Tsukamurella inchonensis on nitric oxide production in murine activated peritoneal macrophages
M. Aghapour1, K. Nofouzi1, B. Baradaran2, B. Ghahvechi3, F. Mahmoodi2, F. Yahyavi4;
1
Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran, Islamic Republic of, 2Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic
Republic of, 3Department of Microbiology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran, Islamic Republic of, 4Department of Basic Sciences, Faculty of Veterinary Medicine, University of
Tabriz, Tabriz, Iran, Islamic Republic of.
P.B.19.05
Low level laser therapy as a novel therapeutic strategy in oral lichen planus
M. N. Draganova-Filipova1, M. Z. Mutafchieva2, P. I. Zagorchev3, G. T. Tomov2;
1
Department of Medical Biology, Faculty of Medicine, Medical University-Plovdiv, Plovdiv, Bulgaria, 2Department Periodontology and Oral diseases, Faculty of Dental Medicine, Medical University-Plovdiv,
Plovdiv, Bulgaria, 3Department of Medical Physics and Biophysics, Faculty of Pharmacy, Medical University-Plovdiv, Plovdiv, Bulgaria.
P.B.19.06 Clinicoserologic correlations of patients with paraneoplastic dermatomyositis: a retrospective single center study
L. Maier1,2, A. Udvardi1,2, Z. E. Betteridge3, B. Volc-Platzer1,2;
1
Department of Dermatology, Sozialmedizinisches Zentrum Ost- Donauspital, Vienna, Austria, 2Medical Research Society, Donaustadt, Vienna, Austria, 3Department of Pharmacy and Pharmacology,
University of Bath, Somerset, United Kingdom.
P.B.19.07
Recruitment of abundant NK cells to the tonsils support the crucial role of innate immunity in pathogenesis of PFAPA syndrome
S. Chiesa1, F. Bellora2, I. Ingrosso1, R. Caorsi1, F. Penco1, A. Bertoni1, C. Pastorino1, A. Omenetti1, M. Finetti1, S. Borghino3, A. Sementa4, R. D’Agostino5, A. Martini1, C. Bottino2,6, M. Gattorno1;
1
Laboratory of Immunology and Rheumatic Diseases , UO Pediatria II, G.Gaslini Institute, Genoa, Italy, 2Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genoa, Italy, 3Molecular
Genetics, G.Gaslini Institute, Genoa, Italy, 4Anatomic Pathology, G.Gaslini Institute, Genoa, Italy, 5UO Otorinolaringoiatria, G.Gaslini Institute, Genoa, Italy, 6G.Gaslini Institute, Genoa, Italy.
P.B.19.08 Regulatory T cells induced by B cells alleviated inflammatory process in an animal model of primary biliary cirrhosis
J. Huang1, Y. Chuang2, B. Chiang1,3;
1
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, 2Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine,
National Taiwan University, Taipei, Taiwan, 3Allergy Center, National Taiwan University, Taipei, Taiwan.
57
P.B.19.09 Type I Interferon Associated Immune Responses In Patients With STING-Associated Vasculopathy With Onset In Infancy
E. Gül1, F. K. Eroğlu2, C. Yakıcıer3, I. Gürsel4, S. Özen2, M. Gürsel1;
1
Middle East Technical University, Ankara, Turkey, 2Hacettepe University, Ankara, Turkey, 3Acıbadem University, İstanbul, Turkey, 4Bilkent University, Ankara, Turkey.
Tuesday
P.B.19.10
Secretory IgA (SIgA): An immunomodulator of clinical activity in undifferentiated spondylitis and reactive arthritis?
P.B.19.11
Clinical features and autoantibody patterns in Zimbabwean patients with autoimmune conditions
P.B.19.12
Differential susceptibility of Th17 and T regulatory cells to CD95-mediated apoptosis in systemic lupus erythematous subjects
P.B.19.13
The loss of CD25 expression in genuine Treg from SLE patients is associated with reduced Treg activity, which can be restored by IL-2 therapy
P.B.19.14
Cell composition of vaginitis: a study on fixed vagina section
P.B.19.15
Anti-signal recognition particle autoantibodies: our experience in a series of twelve patients at the initial diagnosis approach
C. Romero-Sánchez1, C. Arias2, J. Bello-Gualtero1, D. Herrera1, W. Bautista-Molano1, D. Castillo3, J. Londoño4, R. Valle-Oñate4;
1
Universidad Militar Nueva Granada, Bogotá, Colombia, Bogotá, Colombia, 2Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia, 3UIBO Institute
(Oral Basic Research Unit), Universidad El Bosque, 4., Bogotá, Colombia, Bogotá, Colombia, 4Spondyloarthropathy Group, Rheumatology Department, Hospital Militar Central/Universidad de La Sabana,
Bogotá, Colombia.
E. N. Sibanda1, R. Ntozini2, F. Mutapi3;
1
Asthma, Allergy and Immunology Clinic, Harare, Zimbabwe, 2Zvitambo Institute for Medical & Child Health Research, Harare, Zimbabwe, 3Immunology and Infection Research, University of Edinburgh,
Ashworth Laboratories, United Kingdom.
J. Sun, J. Frostegård, A. Liu;
C. von Spee-Mayer1, J. Y. Humrich1, D. Abdirama1, A. Klaus1, A. Rose1, A. Radbruch2, G. Burmester1, G. Riemekasten3;
1
Charité University Hospital, Berlin, Germany, 2German Rheumatism Research Center, Berlin, Germany, 3University Hospital Schleswig-Holstein, Lübeck, Germany.
M. J. Hussain1, O. M. Altaee2, G. B. Alomashi3, A. H. Alhamadani3;
1
King’s College Hospital, London, United Kingdom, 2Al-Qadisiyah University,, Diwaniya, Iraq, 3Al-Qadisiyah University, Diwaniya, Iraq.
A. Tejeda Velarde1, I. Gañán Nieto1, P. B. González Urra1, B. Padilla Merlano2, R. Álvarez Doforno2, G. Roy Ariño1;
1
Immunology Department. Ramón y Cajal Hospital, Madrid, Spain, 2Immunology Department. La Paz Hospital, Madrid, Spain.
P.B.19.16 Atypical serological profiles of case of autoimmune hepatitis in children
S. Gadiri1, H. Meriche1, A. Alliouche kerboua1, H. Brouk2, H. Ouelaa2, N. BouChairpersons: 3;
Departement of immunology, Clinical Hospital St Thérèse ANNABA, Algeria, 2CTS, Hospital Ibn Rochd Annaba, Algeria, 3Departement of paediatric, Clinical Hospital St Thérèse ANNABA, Algeria.
1
P.B.19.17
Multifunctional Th1/Th17 CD4+ T cells dominate in the lungs of pulmonary sarcoidosis patients with a good prognosis
Y. Kaiser, R. Lepzien, B. Dahlberg, J. Wahlström, A. Eklund, A. Smed Sörensen, J. Grunewald;
Dept. of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
P.B.19.18 Inflammatory macrophages contribute to the progression of kidney fibrosis
T. T. Braga1, H. Azevedo1, R. R. Silva1, K. R. Perez2, M. E. Almeida1, N. O. Camara1,2;
1
University of Sao Paulo, Sao Paulo, Brazil, 2Federal University of Sao Paulo, Sao Paulo, Brazil.
P.B.19.19 Modulation of local cytokine network in chronic periodontitis by low-level laser therapy
B. Ismaili1, D. Bokonjic1, Z. Dolicanin2, M. Colic3,1;
1
Medical Faculty Foca,University of East Sarajevo, Sarajevo, Bosnia and Herzegovina, 2State University of Novi Pazar, Novi Pazar, Serbia, 3Medical Faculty of the Military Medical Academy, Belgrade,
Serbia.
P.B.19.20
Autophagy mediates tolerance to wolbachial antigens induced apoptosis and senescence during filarial infections
P.B.19.21
Di(2-ethylhexyl) phthalate-induced cell damage in MES-13 cells is related with ROS, Nrf2, NF-κB, and inflammatory cytokine
P.B.19.22
An assessment of neutrophil function in children with Papillon Lefèvre Syndrome
P.B.19.23
Chemerin increases osteoclasts activity and bone resorption
P.B.19.24
Anti-fibrotic activity of natural killer cells is impaired by hepatic stellate cells- and TGF-β-dependent emperipolesis in liver cirrhosis with chronic HBV infection
K. Vijayan, N. RB;
Anna University, Chennai, India.
P. T. Shen, B. F. Lin;
H. M. Roberts, P. White, M. Grant, I. Chapple;
S. Y. Fukada, G. C. Leite, E. S. Ramos-Junior, F. Q. Cunha;
University of São Paulo, Ribeirão Preto, Brazil.
J. Zhao, Z. Zhang, F. Wang;
Beijing 302 hospital, Beijing, China.
P.B.20 Inflammatory Bowel Disease
Chairpersons: Sheena Cruickshank; Manchester, United Kingdom / Helena Tlaskalova-Hogenova; Prague, Czech Republic
P.B.20.01
Escherichia coli Nissle 1917 supernatant protects BALB/c mice from DSS-induced colitis
P.B.20.02
The role of the Tec-family kinase Itk in the development of inflammatory bowel disease
P.B.20.03
Investigating the role of the TGF-β-activating integrin β8 in inflammatory bowel disease
J. Malkova, K. Klimesova, A. Dusilova, M. Kverka, H. Tlaskalova-Hogenova;
Institute of Microbiology, ASCR, Prague 4, Krc, Czech Republic.
S. Steiner, R. Atreya, M. F. Neurath, B. Weigmann;
Medizinische Klinik 1, Uniklinik Erlangen, Erlangen, Germany.
A. Kelly1,2,3, J. Worthington1,2,3, T. Fenton1,2,3, E. Shuttleworth1,2,3, S. Campbell4, S. Levison4, M. Travis1,2,3;
Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, United Kingdom, 2Wellcome Trust Centre for Cell-Matrix Research, University of Manchester,
Manchester, United Kingdom, 3Manchester Immunology Group, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom, 4Gastroenterology Unit, Manchester Royal Infirmary,
Central Manchester University Hospital NHS Foundation Trust, Manchester, United Kingdom.
1
58
P.B.20.04
Regulatory T cells induced by B cells protect mice from colitis induced by effector T cells
P.B.20.05
Association of IL-1RA single nucleotide Polymorphisms (SNPs) with clinical features of Iranian Inflammatory Bowel Disease(IBD)subjects
P.B.20.07
Differences in Gut Mucus Microbiota Precede Dysbiosis in a Mouse Model of Inflammatory Bowel Disease
P.B.20.08
Role of DNAM-1 family co-receptors on mucosal and peripheral blood T cells populations in paediatric subjects and inflammatory bowel diseases (IBD) patients
P.B.20.09
Ex vivo analysis of cytokine production profile in intestinal mucosa of children with inflammatory bowel disease
T. Y. Shao1, B. L. Chiang1,2;
1
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Ta, Taipei, Taiwan, 2Graduate Institute of Immunology,College of Medicine, National Taiwan University,
Taipei, Taiwan, Taipei, Taiwan.
S. Shahkarami1, N. Ebrahimi Daryani2, M. Sadr1, S. Moossavi3, S. Soltani1, E. Farhadi4, N. Rezaei1,5;
1
Molecular Immunology Research Center, Department of Immunology, School of Medicine,Tehran University, Tehran, Iran, Islamic Republic of, 2Department of Gastroenterology and Hepatology, Tehran
University of Medical Sciences, Tehran, Iran, Tehran, Iran, Islamic Republic of, 3Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran,
Islamic Republic of, 4Hematology Department, School of Allied Medical Science, Iran University of Medical Sciences,, Tehran, Iran, Islamic Republic of, 5Research Center for Immunodeficiencies, Children’s
Medical Center Hospital, Tehran University of Medical Sciences,, Tehran, Iran, Islamic Republic of.
M. Glymenaki1, G. Warhurst2, A. Mcbain1, K. Else1, S. Cruickshank1;
1
University of Manchester, Manchester, United Kingdom, 2Salford Royal Hospital, Manchester, United Kingdom.
S. Battella1, S. Oliva2, G. Di Nardo2, S. Cucchiara2, A. Santoni3, G. Palmieri1;
1
Department of Experimental Medicine - “Sapienza” University of Rome, Rome, Italy, 2Department of Pediatry and child neuropsychiatry - “Sapienza” University of Rome, Rome, Italy, 3Department of
Molecular Medicine - “Sapienza” University of Rome, Rome, Italy.
S. Vitale1,2, C. Strisciuglio2,3, L. Pisapia4, E. Miele2, P. Barba4, A. Vitale2, S. Cenni2, G. Del Pozzo4, R. Troncone2, A. Staiano2, C. Gianfrani1,2;
1
Institute of Protein Biochemistry- CNR, Naples, Italy, 2Department of Translational Medical Science, University of Naples Federico II, Naples, Italy, 3Department of Women, Child and General and
Specialized Surgery, Second University of Naples, Naples, Italy, 4Institute of Genetics and Biophysics ‘Adriano Buzzati Traverso’- CNR, Naples, Italy.
P.B.20.10
Defective IL-10 signaling in antigen presenting cells increases the sensitivity to colitis
P.B.20.11
Indomethacin-induced ileitis in rats is mediated by the NLRP3 inflammasome
P.B.20.12
Is PR3-ANCA a reliable marker of primary sclerosing cholangitis in patients with inflammatory bowel diseases?
P.B.20.13
Protective effect of the aqueous extract from siegesbeckia pubescens on iodoacetamide-induced colitis in rats
P.B.20.14
Elevated Levels Of Gastro-Intestinal Auto-Antibodies And Symptoms Are Associated With Higher Disease Activity In Colombian Patients With Spondyloarthritis
P.B.20.15
T-bet is a Key Modulator of IL-23-driven Pathogenic CD4+ T cell Responses in the Intestine
P.B.20.16
Specific activation of TNFR2 increases suppressor cells in mice with DSS-induced chronic colitis
P.B.20.17
Analysis of regulatory T cells in the Inflammatory Bowel Diseases
P.B.20.18
Trichuris muris infection exacerbates experimental CD45RBhi T cell transfer-colitis characterised by a selective depletion of CD103+ CD11b+ dendritic cells
P.B.20.19
Fisher’s linear discriminant model for complex cytokine profiling: a new approach to prediction of response to tumour necrosis factor antagonists in ulcerative
colitis patients
S. Veenbergen1, L. M. Costes1, M. A. van Leeuwen1, M. J. Girard-Madoux1, G. Driessen1, L. F. de Ruiter1, H. C. Raatgeep1, D. J. Lindenbergh-Kortleve1, L. A. van Berkel1, Y. Simons-Oosterhuis1, A. A. BrouwersHaspels1, A. P. Heikema1, L. de Ridder2, J. C. Escher2, B. E. Clausen3, J. N. Samsom1;
1
ErasmusMC, Rotterdam, Netherlands, 2ErasmusMC-Sophia Children’s hospital, Rotterdam, Netherlands, 3Institute for Molecular Medicine, Johannes Gutenberg-University, Mainz, Germany.
A. Zherebiatiev, A. Kamyshnyi;
Zaporozhye State Medical University, Zaporozhye, Ukraine.
M. Meddeb1, I. Namouchi1, L. Kallel2, L. Laadhar1, A. Filali2, M. Kallel-Sellami1;
1
La Rabta Hospital , Immunology Department, Tunis, Tunisia, 2La Rabta Hospital , Gastroenterology Department, Tunis, Tunisia.
Y. P. Ye, T. L. Teng, Q. Li, S. F. Xu, F. Y. Chen, X. Y. Li;
Zhejiang Academy of Medical Sciences, Hangzhou, China.
T. Krausgruber1,2, C. Schiering1,3, K. Adelmann1, O. Harrison4, A. Chomka1, C. Pearson1, P. Ahern4, M. Oukka5, F. Powrie1,2;
1
Translational Gastroenterology Unit, University of Oxford, Oxford, United Kingdom, 2The Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 3Division of Molecular
Immunology, MRC National Institute for Medical Research, London, United Kingdom, 4Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom, 5Center for Immunity and
Immunotherapies, Seattle, WA, United States.
T. Schmid1, D. Weber-Steffens1, H. Wajant2, D. N. Männel1;
1
Institute of Immunology, Regensburg, Germany, 2Division of Molecular Internal Medicine, Würzburg, Germany.
Tuesday
C. Romero-Sánchez1, W. Bautista-Molano2, V. Parra3, C. Martinez4, F. García5, J. De Avila6, H. Juliao7, J. Bello-Gualtero2, J. Rueda8, J. Londoño9, R. Valle-Oñate10;
1
Universidad Militar Nueva Granada, Bogotá, Colombia, Bogotá, Colombia, 2Faculty of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia, Bogotá, Colombia, 3Faculty of Medicine,
Universidad de La Sabana, Chia, Colombia, Chia, Colombia, 4Coloproctology Deparment, Hospital Militar Central, Faculty of Medicine Universidad Militar Nueva Granada, Bogotá, Colombia, Bogotá,
Colombia, 5Coloproctology Deparment, Hospital Militar Central, Bogotá, Colombia, Bogotá, Colombia, 6UIBO Institute, Universidad El Bosque, Bogotá, Colombia, Bogotá, Colombia, 7Gastroenterology
Deparment, Hospital Militar Central, Bogotá Colombia, Bogotá, Colombia, 8Faculty of Medicine, Universidad de la Sabana, Chía, Colombia, Chia, Colombia, 9Spondyloarthropathy Group, Rheumatology
Department, Hospital Militar Central/Universidad de La Sabana, Chia, Colombia, Chia, Colombia, 10Spondyloarthropathy Group, Rheumatology Department, Hospital Militar Central, Faculty of Medicine,
Universidad Militar Nueva Granada, Bogotá, Colombia, Bogotá, Colombia.
R. Marrakchi1, B. Neili1, A. Abidi1, G. Guggino2, A. Gati1, K. Hamdi3, N. Ben Moustapha4, F. Dielli2, A. benammar Elgaaied1;
1
1Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences, University of Tunis El, Tunis, Tunisia, 2Center for advanced diagnostics and biomedical research CLADIBIOR, University of
Palermo, and Palermo, Italy, Palermo, Italy, 3Laboratory of genetics, Immunology and Human Pathologies, Faculty of Sciences of Tunis, University Tunis El Manar, Tunis, Tunisia, Tunis, Tunisia, 41Service of
Gastroenterology A University Hospital El Rabta, Tunis, Tunisia, Tunis, Tunisia.
D. Sorobetea1, A. Rivollier2, W. Agace1,2, M. Svensson-Frej1;
1
Immunology Section, Department of Experimental Medical Sciences, Medical Faculty, Lund University, Lund, Sweden, 2Section of Immunology and Vaccinology, National Veterinary Institute, Technical
University of Denmark, Fredriksberg, Denmark.
I. V. Obraztsov1,2, M. V. Shapina1, K. E. Shirokikh1, I. L. Khalif1;
1
A.N. Ryzhikh State Scientific Centre for Coloproctology, Moscow, Russian Federation, 2D. Rogachev State Scientific and Clinical Centre for Paediatric Oncology, Haematology and Immunology, Moscow,
Russian Federation.
P.B.20.20
Microbial inactivation of pancreatic proteases protects epithelial barrier integrity in the large intestine
P.B.20.21
The expression intensity studies of NOD-like receptors with lymphocytes of colon after recombinant antagonist of receptors of interleukin-1 treatment in
oxazolone-induced colitis in rats
H. Yoon, G. Hörmannsperger, D. Haller;
Technical University of Munich, Freising, Germany.
E. Melihova, A. Kamyshnyi;
P.B.20.22
Absence of LPS in the lamina propria of UC identifies patients in remission who share immunological and mucosal structural features with active disease and may
be at risk of relapse
L. Greathead1, R. Goldin1, P. Kelleher1, A. Steel2;
1
Imperial College, London, United Kingdom, 2Chelsea & Westminster Hospital NHS Trust, London, United Kingdom.
P.B.21 Neuroimmunology and Multiple Sclerosis
Chairpersons: Hans Lassmann; Vienna, Austria / Luisa M. Villar-Gumerans; Madrid, Spain
P.B.21.01
Regulatory T cells control central nervous system inflammation by TNF / TNFR2 signaling pathway
P.B.21.02
Rheumatoid arthritis leads to altered gene expression in the brain and behavioral changes in mice
P.B.21.03
Increased Tim-3 expressions in the brains of different mouse models with toxoplasmic encephalitis
P.B.21.04
Direct ex vivo characterization of autoreactive T cells provides no evidence for autoantigen-based high affinity selection and expansion in autoimmune patients
P.B.21.05
Correlation between HMGB1 plasma levels and the number of MRI lesions and EDSS in MS patients
P.B.21.06
Characteristics of lung T cell subsets in multiple sclerosis patients with respect to smoking and β-interferon treatment
P.B.21.07
Anti-inflammatory effect of CD6 blockade
C. Pouchy1, D. Sleurs1, S. Gregoire1, Y. Lombardi1, N. Chanson1, G. Martin2, G. Marodon1, Y. Grinberg-Bleyer3, B. Salomon1;
1
CIMI - UPMC UMRS CR7 - Inserm U1135, Paris, France, 2Departments of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Department of
Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, United States.
K. M. Andersson1, L. Leifsdottir1, M. C. Erlandsson1, M. Pekna2, K. Olmarker3, M. Pekny2, M. I. Bokarewa1;
1
Dep. Rheumatology and Inflammation Research, Inst. Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden, 2Center for Brain Repair and Rehabilitation, Department
of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden, 3Musculoskeletal Research,
Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.
F. Lu1,2, B. Wu1,2, S. Huang3;
1
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, 2Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, 3School of
Medicine, Jinan University, Guangzhou, China.
S. Gamradt1, F. Hahn1, J. Ahlers1, B. Rosche2, M. Assenmacher3, P. Bacher1, A. Scheffold1;
1
Dep. of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin, Berlin, Germany, 2Dep. of Neurology and Experimental Neurology, Charité-Universitätsmedizin, Berlin, Germany, 3Miltenyi
Biotec GmbH, Bergisch Gladbach, Germany.
M. Buc1, B. Gajdosechova1, V. Durmanova1, Z. Vascakova1, L. Maruscakova1, D. Cudrakova-Copikova2, P. Turcani2, I. Lisa3, K. Gmitterova3, E. Klimova4, M. Bucova1;
1
Department of Immunology, Comenius University School of Medicine, Bratislava, Slovakia, 21st Department of Neurology, Comenius University School of Medicine and University Hospital, Bratislava,
Slovakia, 32nd Department of Neurology, Comenius University School of Medicine and University Hospital, Bratislava, Slovakia, 4Department of Neurology, Teaching Hospital of JA Reiman and Faculty of
Health, University of Presov in Presov, Presov, Slovakia.
M. Ostadkarampour1, S. Kullberg1, J. Öckinger1, M. Hagemann-Jensen1, A. Eklund1, F. Piehl2, T. Olsson2, J. Grunewald1, J. Wahlström1;
1
Respiratory Medicine Unit, Department of Medicine Solna and CMM, Karolinska Institutet, Stockholm, Sweden, 2Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet,
Stockholm, Sweden.
R. F. de Freitas*1,2, A. Agua-Doce*1,2, S. Perez3, L. Padron3, K. Leon3, L. Graca1,2;
1
Instituto de Medicina Molecular, Lisboa, Portugal, 2Instituto Gulbenkian de Ciência, Oeiras, Portugal, 3Centro de Inmunologia Molecular, Habana, Cuba.
59
Tuesday
P.B.21.08
Krebs cycle potentiation through coenzyme A fueling has immunosuppressive effects and inhibits autoimmune disease development
P.B.21.09
Nature-derived circular peptides as oral immunosuppressive therapeutics
P.B.21.10
Andrographolide ameliorates experimental autoimmune encephalomyelitis
P.B.21.11
Granulocyte-Macrophage Colony-Stimulating Factor: Expression and Role in Human Immune Cells and Relevance to Multiple Sclerosis
P.B.21.12
Twelve-months follow-up of minoritary peripheral B and T cell subsets during fingolimod treatment in relapsing-remitting multiple sclerosis patients
P.B.21.13
microRNA-155 contributes to re-activation of encephalitogenic T cells
P.B.21.14
Vitamin D and MS: relationship with response to treatment and with patient inflammatory profile
P.B.21.15
Autologous hematopoietic stem cell transplantation for multiple sclerosis - A Singapore experience
P.B.21.16
Autophagy and SQSTM1/p62 expression in multiple sclerosis
P.B.21.17
Increased caspase-1 and EBV load in active phase of Multiple Sclerosis disease
P.B.21.18
Differential frequency of CD8+ T cell subsets in multiple sclerosis patients with various clinical patterns
P.B.21.19
Changes in lymphocyte subsets as a potentially useful biomarker of conversion from CIS to clinically definite MS
P.B.21.20
Study of the pathogenic activity IgM antibodies against phosphatidilcoline in a new animal model of experimental allergic encephalitis
P.B.21.21
Study of the relation between humoral immune response and oxidative stress in multiple sclerosis patients
S. Angiari, T. Carlucci, S. L. Budui, S. D. Bach, B. Rossi, C. Laudanna, G. Constantin;
University of Verona, Verona, Italy.
K. Thell, R. Hellinger, E. Sahin, T. Haider, G. Schabbauer, C. W. Gruber;
Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
J. E. Tichauer1, E. Acuña1, M. Castro2, L. Reyes3, C. Cárcamo4, R. A. Burgos5, J. L. Hancke5, R. Naves1;
1
Biomedical Sciences Institute, School of Medicine, Universidad de Chile., Santiago, Chile, 2Department of Health Sciences, Universidad San Sebastián, Santiago, Chile., Santiago, Chile, 3Department of
Biological and Chemistry Sciences, Universidad San Sebastián, Santiago, Chile., Santiago, Chile, 4Department of Neurology, School of Medicine, Pontificia Universidad Católica de Chile., Santiago, Chile,
5
Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile., Valdivia, Chile.
J. Aram, B. Gran, C. S. Constantinescu;
A. Teniente-Serra, J. Hervás, B. Quirant-Sánchez, M. Mansilla, L. Grau-López, C. Ramo-Tello, E. Martínez-Cáceres;
Germans Trias i Pujol University Hospital, Badalona, Spain.
S. M. Stanisavljevic1, B. Jevtić1, G. Timotijević2, M. Momčilović1, M. Mostarica Stojković3, D. Miljković1;
1
Institute for Biological Research Siniša Stanković, Belgrade, Serbia, 2Institute for Molecular Genetics and Genetic Engineering, Belgrade, Serbia, 3Institute for Microbiology and Immunology, School of
Medicine, Belgrade, Serbia.
R. Alenda1, L. Costa-Frossard2, O. Pastor3, E. Rodríguez-Martín1, C. Picón1, J. C. Álvarez-Cermeño2, L. M. Villar1;
1
Department of Immunology. Hospital Ramón y Cajal, Madrid, Spain, 2Department of Neurology. Hospital Ramón y Cajal, Madrid, Spain, 3Department of Biochemistry. Hospital Ramón y Cajal, Madrid,
Spain.
P. Ratnagopal;
Singapore General Hospital, Singapore, Singapore.
V. Paunovic1, K. Janjetovic1, M. Milenkovic1, Z. Stanojevic2, I. Dujmovic3, J. Drulovic3, V. Pravica1, V. Trajkovic1;
1
Institute for Microbiology and Immunology, School of Medicine, University of Belgrade, Belgrade, Serbia, 2Institute for Medicinal and Clinical Biochemistry, School of Medicine, University of Belgrade,
Belgrade, Serbia, 3Clinic of Neurology, Clinical Centre Serbia, Belgrade, Serbia.
M. Izad1,2, M. Beheshti1, Z. Salehi1, B. Nomanpour3, H. Shirzad4, R. Abolfazli5, M. Naseri6;
1
Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 2MS Research Center, Neuroscience institute, Tehran University of Medical
Sciences,, Tehran, Iran, Islamic Republic of, 3Department of Microbiology,Kermanshah University of Medical Sciences, Kermanshah, Iran, Islamic Republic of, 4Cellular and Molecular research center, Shahre-kord University of Medical Sciences,, Shahr-e- kord, Iran, Islamic Republic of, 5Department of Neurology, Amiralam General Hospital Faculty of Medicine, Tehran University of Medical Sciences, Tehran,
Iran, Islamic Republic of, 6Department of Virology, Faculty of public health, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
Z. Salehi1, M. Izad1,2, M. A. Sahraian2, E. Janzamin3, P. Khosravani3;
1
Immunology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 2MS Research Center, Neuroscience institute, Tehran University of Medical Sciences,
Tehran, Iran, Islamic Republic of, 3Flow Cytometry laboratory, Department of Stem Cell and Developmental Biology, Royan Institute, Tehran, Iran, Islamic Republic of.
H. Posová1, D. Horáková2, V. Capek2, T. Uher2, Z. Hrušková1, E. Havrdová2;
1
Inst. Immunology and Microbiology, 1st Medical Faculty, Charles University, Prague, Czech Republic, 2Department of Neurology, 1st Medical Faculty, Charles University, Prague, Czech Republic.
C. Sebal1, U. Muñoz1, J. Fraussen2, V. Somers2, C. Paino3, E. Escudero1, M. Sádaba1;
1
Dept. of Medical Physiology, School of Medicine, CEU-San Pablo University, Madrid, Spain, 2Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life
Sciences, Diepenbeek, Belgium, 3Servicio de Investigación. Hospital Ramón y Cajal., Madrid, Spain.
C. Sebal1, M. Sádaba1, E. Escudero1, C. Sloan2, Ú. Muñoz1;
1
Dept. of Medical Physiology, School of Medicine, CEU-San Pablo University, Madrid, Spain, 2Neuropathology Dept. Level 1, West Wing, John Radcliffe Hospital, Oxford, United Kingdom.
P.B.22 (Chronic) Inflammatory Joint Disease - Part 2
Chairpersons: Winfried Graninger; Graz, Austria / Leonie Taams; London, United Kingdom
P.B.22.01
CD4+ T cells of patients with rheumatic disorders show phenotypic and functional exhaustion
P.B.22.02
Understanding Apoptotic Epitope-specific CD8+ T cell fate: the borderline between tolerance and autoimmunity
P.B.22.03
Pro-inflammatory FcRL4+ memory B cells in joints of RA patients; immunoglobulin gene characteristics and antigen specificity
D. Buschjäger1, T. Frenz1, L. Vaas1, R. E. Schmidt2, T. Witte2, U. Kalinke1;
1
Twincore, Institute for Experimental Infection Research, Hannover, Germany, 2Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.
A. Citro, C. Martire, H. Martini, R. Scrivo, F. Miranda, G. Valesini, V. Barnaba;
Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Roma, Italy.
K. Amara1, L. Yeo2, N. Sippl1, E. Clay2, P. Titcombe1, A. Filer2, K. Raza2, V. Malmstrom1, D. Scheel-Toellner2;
Karolinska Institute, Stockholm, Sweden, 2University of Birmingham, Birmingham, United Kingdom.
1
60
P.B.22.04
Iga autoantigens a link between the gut and the anti-tnf therapy response in rheumatoid arthritis patients analysed in two idependt clinical trials
P.B.22.05
Culture expanded primary chondrocytes have potent immunomodulatory properties and do not induce an allogeneic immune response
P.B.22.06
Interaction between activated lymphocytes and mesenchymal cells promotes IL-17 secretion, partly mediated by podoplanin
P.B.22.07
Changes in zinc and cadmium homeostasis can alter survival and inflammatory status in mesenchymal cells
P.B.22.08
Novel candidates for genetic control of Collagen Induced Arthritis are involved in transcriptional regulation of lymphocyte activity
P.B.22.09
Specific angiotensin type II receptor stimulation attenuates collagen-induced arthritis by modulating the Th17/Treg balance
Z. Konthur1, U. Nonhof1, M. Wiemkes2, J. Detert2, T. Braun2, G. Burmester2, K. Skriner2;
1
Drug Response Dx GmbH, Hennigsdorf, Germany, 2Charité University Medicine, Berlin, Germany.
P. Lohan, O. Treacy, K. Lynch, F. Barry, M. Murphy, M. D. Griffin, T. Ritter, A. E. Ryan;
Regenerative Medicine Institute, Galway, Ireland.
M. Noack, N. Thiam, P. Miossec;
EA4130 Immunogenomics and Inflammation Unit, Lyon, France.
P. Bonaventura1, G. Benedetti1, F. Lavocat1, A. Lamboux2, F. Albarède2, P. Miossec1;
1
Edouard Herriot hospital- Immunogenomic and inflammation unit EA4130, Lyon, France, 2Ecole Normale Supérieure (ENS) of Lyon- geology laboratory – department of earth sciences, Lyon, France.
S. Sardar1, D. Vaartjes2, A. Kerr3, K. Kanne1, K. Svan1, Å. Andersson1;
1
Section for Systems Pharmacology, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen Ø, Denmark, 2Division of Medical Inflammation Research, Department of
Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, 3School of Biomolecular and Biomedical Science, University College Dublin, Ireland, Dublin, Ireland.
B. Sehnert1,2, V. Valero-Esquitino3, G. Schett4, U. M. Steckelings5, R. E. Voll1,2;
1
Center for Chronic Immunodeficiency, Medical Center-University Freiburg, Freiburg, Germany, 2Department of Rheumatology and Clinical Immunology, Medical Center-University Freiburg, Freiburg,
Germany, 3Center for Cardiovascular Research, Charité-Medical Faculty Berlin, Berlin, Germany, 4Department of Rheumatology and Clinical Immunology, University Hospital Erlangen, University of
Erlangen-Nürnberg, Erlangen, Germany, 5IMM - Dept. of Cardiovascular & Renal Research, University of Southern Denmark, Odense, Denmark., Odens, Denmark.
P.B.22.10
Computer model analysis of the difference between F759 and wild type mice in rheumatoid-like arthritis emergence
P.B.22.11
Meloxicam effects on serum cytokine levels and cartilage degradation in iodoacetate-induced rat osteoarthritis
P.B.22.12
Nanobody-based sandwich ELISA for human TL1A: a promising tool for diagnosis and monitoring of several autoimmune and inflammatory diseases
P.B.22.13
Proinflammatory crosstalk between rheumatoid arthritis synovial fibroblasts and THP-1 monocytic cells is mediated via secreted extracellular vesicles
P.B.22.14
A transititional fibroblast phenotype exists in very early rheumatoid arthritis: Modulation of endothelial responses and lymphocyte recruitment
P.B.22.15
Distinct expression of T-cell homing molecules in human autoimmune lymph node stromal cells upon TLR-3 triggering
P.B.22.16
Upregulation of IL23A mRNA and IL-23 serum level in chronic inflammatory arthritides
P.B.22.17
Anti-infliximab antibodies production and clinical consequences: adverse reaction and loss of response
P.B.22.19
Effect of non-functional LILRA3 variants on susceptibility to spondyloarthropaties
P.B.22.20
The role of microRNA-146a in inflammatory arthritis
P.B.22.21
Metabolic profiling of synovial tissue shows altered glucose metabolism in rheumatoid arthritis samples.
S. Yamada1, A. Yoshimura2, T. Atsumi3, M. Murakami3;
1
Okayama University of Science, Okayama, Japan, 2Keio University, Tokyo, Japan, 3Hokkaido University, Sapporo, Japan.
E. E. Nagy1,2, E. Vajda3, F. Annamaria4, T. Aczel1, E. Horvath5;
1
Dept. of Pharm. Biochemistry, University of Medicine and Pharmacy, Targu-Mures, Romania, 2Lab. Med. Anal., Clinical County Hospital, Targu-Mures, Romania, 3Dept. of Drug Analysis, University of
Medicine and Pharmacy, Targu-Mures, Romania, 4Dept. of Physiopathology, University of Medicine and Pharmacy, Targu-Mures, Romania, 5Dept. of Pathology, University of Medicine and Pharmacy,
Targu-Mures, Romania.
L. Vanrell, N. Silva, G. González-Sapienza;
Facultad de Química-UdelaR, Montevideo, Uruguay.
B. Sódar1, X. Osteikoetxea1, A. Németh1, K. Pálóczi1, M. Pásztói1, K. Szabó-Taylor1, K. Vukman1, É. Pállinger1, A. Zakar1, Á. Kittel2, E. Buzás1;
1
Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, 2Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
J. Hähnlein1,2, T. Ramwadhdoebe1,2, F. Berger3, T. Geijtenbeek2, P. Tak4,5,6, L. van Baarsen1,2;
1
Amsterdam Rheumatology & immunology Center (ARC), Academic Medical Center, Amsterdam, Netherlands, 2Department of Experimental Immunology, Academic Medical Center, Amsterdam,
Netherlands, 3Division of Radiology, Academic Medical Center, Amsterdam, Netherlands, 4University of Cambridge, Cambridge, United Kingdom, 5Ghent University, Ghent, Belgium, 6GlaxoSmithKline,
Stevenage, United Kingdom.
I. Manolova1, L. Miteva2, M. G. Ivanova3, R. Stoilov3, S. A. Stanilova2;
1
Trakia University, Medical Faculty, Stara Zagora, Bulgaria, 2Trakia University, Medical Faculty, Department of Molecular Biology, Immunology and Medical genetics, Stara Zagora, Bulgaria, 3Clinic of
Rheumatology, University Hospital, Medical University, Sofia, Bulgaria.
Tuesday
H. M. McGettrick1, H. Munir2, C. S. Davies3, K. Raza1, G. B. Nash2, C. D. Buckley1, A. Filer1;
1
Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom, 2School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, United Kingdom,
3
Sandwell and South West Birmingham NHS Trust, Birmingham, United Kingdom.
A. Matucci1, A. Vultaggio1, F. Nencini2, S. Pratesi2, E. Maggi2;
1
AOU Careggi, Florence, Italy, 2Dept of Sperimental and Clinic Medicine, University of Florence, Italy.
D. Ordóñez del Valle, K. Kniesch, H. Z. Low, N. T. Baerlecken, R. E. Schmidt, T. Witte;
V. Saferding, A. Puchner, E. GoncalvesAlves, E. Sahin, M. Hofmann, S. Hayer, J. S. Smolen, K. Redlich, S. Blüml;
Medical University Vienna, Vienna, Austria.
R. Volchenkov1, M. Dung Cao2, K. B. Elgstøen3, G. L. Goll4, K. Eikvar4, O. Bjørneboe5, T. F. Bathen2, H. L. Holen6, B. S. Skålhegg1;
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway, 2Department of Circulation and Medical Imaging, Faculty of medicine, Norwegian University of Science and
Technology (NTNU), Trondheim, Norway, 3Department of Medical Biochemistry, Oslo University Hospital, Rikshospitalet, Oslo, Norway, 4Department of Rheumatology, Diakonhjemmet Hospital, Oslo,
Norway, 5Martina Hansen’s Hospital, Gjettum, Norway, 6Rheumatech AS, Oslo, Norway.
1
P.B.22.22
Novel biomarker for rheumatoid arthritis disease activity
P.B.22.23
FGF receptor antagonists show anabolic, anti-catabolic and anti-inflammatory effects in OA cartilage
P.B.22.24
Identification of small molecule inhibitors of elastase-mediated IL-36γ activation
A. Myngbay1, A. Adilbayeva1, Y. Bexeitov1, B. P. Yevstratenko2, R. M. Aitzhanova2, N. K. Otarbayev2, V. A. Adarichev1,3,4;
1
National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan, 2Republican Diagnostic Center, Astana, Kazakhstan, 3Albert Einstein College of Medicine, Department of Medicine (Division of
Rheumatology) and Department of Microbiology & Immunology, Bronx, NY, United States, 4Nazarbayev University, Department of Biology, Astana, Kazakhstan.
E. Nummenmaa1, M. Hämäläinen1, T. Moilanen1,2, K. Vuolteenaho1, E. Moilanen1;
1
The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, 2Coxa Hospital for Joint Replacement, Tampere, Finland.
E. V. Belotcerkovskaia1, P. B. Davidovich1, S. Sura-Trueba1, S. J. Martin1,2;
1
St. Petersburg State Technological Institute, St. Petersburg, Russian Federation, 2Trinity College, Dublin 2, Ireland.
P.B.23 Animal Models of Autoimmunity
Chairpersons: Axel Roers; Dresden, Germany / Fons van de Loo; Nijmegen, Netherlands
P.B.23.01
Activin-A attenuates central nervous system (CNS) autoimmune inflammation
P.B.23.02
ADAMTS13 reactive CD4+ T cells targeting a single CUB-2 domain derived peptide in autoimmune thrombotic thrombocytopenic purpura
P.B.23.04
Expression of micro-RNA 181a in NOD/J and congenic NOD.CD45.2 mice
P.B.23.05
Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction
P.B.23.07
Autoimmunization processes in Collagen XVII transgenic mice
A. Trochoutsou1, M. Semitekolou1, S. Tousa1, V. Kloukina1, I. Morianos1, T. Kalamatas2, G. Xanthou1;
1
Biomedical Research Foundation of the Academy of Athens, Athens, Greece, 2Department of Neurology “G. Gennimatas”, General Hospital of Athens, Athens, Greece.
F. C. Verbij1, F. de Heij1, P. Kaijen1, M. Zuurveld1, W. Bril1, R. Fijnheer2, N. Sorvillo1, A. ten Brinke1, J. Voorberg1;
1
Sanquin Blood Supply, Amsterdam, Netherlands, 2UMC Utrecht, Utrecht, Netherlands.
G. Beilhack1, L. Schirmbeck1, W. Sattler1, B. Jug1, A. Beilhack2, R. Monteforte1;
1
Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria, 2Zentrum für Experimentelle Molekulare Medizin, University of Würzburg, Würzburg, Germany.
S. C. Edwards, S. C. Higgins, K. H. Mills;
Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
N. Kokkonen1,2, T. Hurskainen1,2, R. Sormunen3, J. Jackow4, S. Löffek5, R. Soininen3, C. W. Franzke6, L. Bruckner-Tuderman6, K. Tasanen1,2;
University of Oulu, Dept. of Dermatology, Oulu, Finland, 2Medical Research Center Oulu, Oulu, Finland, 3Biocenter Oulu, Oulu, Finland, 4Laboratory of genetic skin diseases, Paris, France, 5University
Duisburg-Essen, Essen, Germany, 6University of Freiburg, Dept. of Dermatology, Freiburg, Germany.
1
P.B.23.08
C1q deficiency accelerates the development of murine lupus independently of C3 activation
P.B.23.09
Accelerated release of CD11bbrightCD18dim neutrophils and peripheral destruction by anti-neutrophil antibodies in a canine model of drug induced immune
mediated neutropenia
G. Ling, B. Lau, C. Giacomassi, B. Norzawani, J. Strid, M. Botto;
M. Winter1, M. Stefan-Gueldner2, A. Braendli-Baiocco1, S. Kustermann3, M. Festag3, M. Juedes2;
1
Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences – Pathology and Immunology, Roche Innovation Center, Basel, Switzerland, 2Roche Pharmaceutical Research and
Early Development, Pharmaceutical Sciences – Project Leaders, Roche Innovation Center, Basel, Switzerland, 3Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences –
Pharmacology and Mechanistic Safety, Roche Innovation Center, Basel, Switzerland.
P.B.23.10
The role of regulatory T cells in experimental autoimmune glomerulonephritis
P.B.23.11
Relapsing-remitting experimental autoimmune uveitis (EAU) in rats is efficiently treated by oral tolerance induction
S. Ahrens1, S. Hünemörder1, V. Schumacher1, H. Hopfer2, H. Mittrücker1;
1
Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Institute of Pathology, University Hospital Basel, Basel, Switzerland.
G. Wildner, A. Huber, M. Diedrichs-Möhring;
Section of Immunobiology, Dept. of Ophthalmology, Clinic of the University of Munich, Munich, Germany.
61
P.B.23.13
The melanocortin-receptor agonist NDP-MSH ameliorates ongoing experimental autoimmune encephalomyelitis by preventing leukocyte extravasation and
neuronal damage
N. Sucker1, A. Herrmann2, C. Faber3, L. Klenner1, C. Baumann1, K. Holz1, M. Schneeweiß1, H. Wiendl2, T. A. Luger1, S. G. Meuth2, K. Loser1;
1
Department of Dermatology, Münster, Germany, 2Department of Neurology, Münster, Germany, 3Institute for Clinical Radiology, Münster, Germany.
P.B.23.15
Aicardi-Goutières syndrome: Lupus-like autoimmune disease caused by inappropriate intracellular nucleic acid sensing
P.B.23.16
Nanobodies that antagonize the P2X7 ion channel ameliorate inflammatory diseases
P.B.23.17
Deletion of Galectin 3 Enhances Primary Biliary Cirrhosis in Mice by Enhanced Apoptosis of Biliary Epithelial Cells and Release of Autoantigens
P.B.23.18
Development of a mouse model mimicking paraneoplastic neurological disease: how anti-tumor immunity can lead to autoimmunity in the CNS
P.B.23.19
Role of Prostaglandin E2 Receptor EP4 in Nephrotoxic Serum Nephritis
B. Hiller, K. Peschke, S. Tina, M. Kleefisch, M. Schulz, A. Hennig, R. Behrendt, A. Roers;
Institute for Immunology, TU Dresden, Dresden, Germany.
F. Koch-Nolte1, W. Danquah1, C. Meyer-Schwesinger1, B. Rissiek1, C. Pinto1, P. Lorenz1, A. Serracant1, F. Haag1, E. Tolosa1, T. Laeremans2, C. Stortelers2;
1
University Medical Center Hamburg, Hamburg, Germany, 2Ablynx nv, Ghent, Belgium.
A. Arsenijević, Marija Milovanović, Jelena Milovanović, Bojana Stojanović, Nataša Zdravković, Patrick Leung, Fu-Tong Liu, Erick Gershwin, Miodrag L. Lukić;
Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences University of Krag, Kragujevac, Serbia.
C. Gebauer1, B. Pignolet1, L. Yshii1, B. Engelhardt2, D. Brassat1, R. Liblau1;
1
CPTP, INSERM U1043 - CNRS UMR5282-Université Toulouse III, Toulouse, France, 2Theodor Kocher Institut, University of Bern, Bern, Switzerland.
I. Aringer1,2, A. Kirsch3, K. Artinger1, C. Schabhüttl1, K. Jandl2, A. Kozina4, T. Stojakovic5, P. Eller6, A. Rosenkranz1, Á. Heinemann2, K. Eller1;
Division of Nephrology,Medical University of Graz, Graz, Austria, 2Institute of Experimental and Clinical Pharmacology, Graz, Austria, 3Division of Nephrology, Medical University of Graz, Graz, Austria,
4
Institute of Molecular Biology and Biochemistry, Graz, Austria, 5Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria, 6Division of Angiology,Medical
University of Graz, Graz, Austria.
1
Tuesday
P.B.23.20
ROS deficiency exacerbates glucose-6-phosphate isomerase-peptide induced arthritis by regulating γ-interferon-inducible-lysosomal thiol reductase expression
P.B.23.21
P-selectin deficiency alters the population balance of immune circulating cells
P.B.23.22
Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction in B cell numbers
P.B.23.23
Mouse SCID models of Systemic lupus erythematosus
P.B.23.24
Increased salt exposure affects both lymphoid and myeloid effector functions, influencing antibody-induced arthritis but not autoimmunity
M. Yang, R. Holmdahl;
R. González-Tajuelo, E. Lozano-Andrés, J. Silván, A. Urzainqui;
Fundación de Investigación Biómedica, IIS–Princesa, Immunology Department, Hospital Universitario de la Princesa, Madrid, Spain.
W. A. Figgett1, D. Deliyanti1, K. A. Fairfax2,1,3, P. Quah1, J. L. Wilkinson-Berka1, F. Mackay1;
1
Monash University, Melbourne, Australia, 2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, 3Melbourne University, Melbourne, Australia.
A. I. Tchorbanov, N. Kerekov, K. Nikolova-Ganeva, N. Mihaylova;
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
B. Raposo1, D. Vaartjes1, K. Nandakumar1, R. Holmdahl1,2;
1
Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, 2Section for Medical Inflammation Research, Southern Medical
University,, Guangzhou, China.
P.B.24 Mediators of (Neuro) Immune Regulation
Chairpersons: Jon Lampa; Stockholm, Sweden / Manuel Friese; Hamburg, Germany
P.B.24.01
Novel Nuclear factor-kappa B targeting peptide suppresses beta-amyloid induced inflammatory and apoptotic responses in neuronal cells
P.B.24.02
Vagus nerve stimulation decrease CD4+ but not CD8+ T cell activation in immune organs in mice
P.B.24.03
Morphological changes in Substance P myenteric varicosities of the small intestine after chronic F exposure
P.B.24.04
Repeated challenge with the hapten oxazolone provokes persistent vulvar mechanical sensitivity and inflammatory tissue changes in previously sensitized ND4
mice
M. Srinivasan, D. Lahiri;
Indiana University, Indianapolis, IN, United States.
J. Estelius, E. Le Maître, J. Lampa;
C. G. Melo1, S. R. Souza2, A. D. Heubel1, J. G. Souza1, I. Zignani2, P. S. Watanabe2, J. P. Matins2, J. N. Zanoni2, M. R. Buzalaf1;
1
University of Sao Paulo, Bauru-SP, Brazil, 2State University of Maringa, Maringa-PR, Brazil.
D. Chatterjea1, T. Martinov2, C. Benck1;
1
Macalester College, Saint Paul, MN, United States, 2University of Minnesota, Minneapolis, MN, United States.
P.B.24.05
Ischemic stroke induces a loss of innate-like marginal zone B cell functions and a susceptibility to bacterial pneumonia via b-adrenergic receptor signalling
L. McCulloch1, S. Hulme2, P. Tyrrell3,2, S. J. Hopkins4, C. J. Smith3,2, B. W. McColl1;
1
Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush Campus, United Kingdom, 2Stroke Services, Clinical Sciences Building, Hope Hospital, Salford, United Kingdom, 3University of
Manchester, Manchester, United Kingdom, 4North Western Injury Research Collaboration (NWIRC), Clinical Sciences Building, Hope Hospital, Salford, United Kingdom.
P.B.24.06 Modulatory effects of Nicotine on human astrocytes stimulated with Interleukin-1beta
P. Revathikumar, S. Gopalakrishnan, E. le maître, J. Lampa;
Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
P.B.24.07
Prostaglandins as central mediators of neuro-immune pathways
P. Revathikumar1, N. Agalave2, E. Le Maître1, C. I. Svensson2, P. Jakobsson1, M. Korotkova1, J. Lampa1;
1
Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.
P.B.24.08 Thymic and immunological phenotype of growth hormone releasing hormone (GHRH)-deficient mice in basal conditions
G. Bodart1, K. Fahrat1, C. Renard-Charlet1, R. Salvatori2, V. Geenen1, H. Martens1;
1
Center of Immunoendocrinology, GIGA-I3, University of Liege, Liège, Belgium, 2Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
P.B.24.10
IL-17A and IFN-gamma are up-regulated both in CD4 and gamma/delta T cells in active Behcet’s disease patients
P.B.24.11
the effect of siRNA caveolin-1 on the expression of tumor associated factors SDF-1, EGF, FSP-1 in fibroblasts co-cultured with breast cancer cells
P.B.24.12
Macrophage inhibitory cytokine 1 (MIC-1)/growth differentiation factor 15 (GDF15) suppresses pulmonary inflammation and pathology in a mouse model of
chronic obstructive pulmonary disease
V. Abbasova, A. Gül, G. Saruhan-Direskeneli;
Istanbul Medical Faculty, Istanbul, Turkey.
W. Li;
Nanchang University,China, Nanchang, China.
M. Fricker1, V. W. Tsai2, D. A. Brown2, S. N. Breit2, P. M. Hansbro1;
1
University of Newcastle, Hunter Medical Research Institute, New Lambton Heights, Australia, 2St. Vincent’s Centre for Applied Medical Research, St. Vincent’s Hospital and University of New South Wales,
Sydney, Australia.
P.B.24.13
IL-36alpha expression is elevated in ulcerative colitis and promotes colonic inflammation
P.B.24.14
Proinflammatory cytokine gene polymorphisms in Greek asthmatic patients
S. E. Russell1, R. M. Horan1, A. Stefanska1, A. Carey2, S. Hussey2, P. T. Walsh1,2;
1
Trinity College Dublin, Dublin, Ireland, 2National Childrens Research Centre, Dublin, Ireland.
E. Kontakioti1, K. Domvri1, A. Gerofotis2, A. Vassilaki3, G. Kokaraki3, K. Porpodis1, K. Zarogoulidis1, D. Papakosta1, M. Daniilidis2;
Asthma Clinic, Pulmonary Department, Aristotle University of Thessaloniki, George Papanikolaou Hospital, Exochi, Thessaloniki, Greece, 2First Department of Internal Medicine, Ahepa University Hospital,
Thessaloniki, Greece, 3Immunogenetics Research Laboratory, 1st Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece.
1
62
P.B.24.15
Serum level of IL-12 and sVEGFR1/VEGF ratio in patients with cognitive disorders
P.B.24.16
Anti-Inflammatory Effects of Equine Adipose Mesenchymal Stem Cells for Bone Fracture in Thoroughbred Racehorses
P.B.24.17
Correlation between clinical symptoms and peripheral immune response in HAM/TSP
P.B.24.18
Human cytomegalovirus encoded cmvIL-10 induces human IL-10 protein secretion via induction of heme oxygenase 1
P.B.24.19
The role of reactive oxygen species in avian influenza H5N1 and H7N9 infection
P.B.24.20
S. aureus and E. coli induce IL-32 gene expression to different extents during infection of bovine mammary gland epithelial cells
I. K. Malashenkova1, S. A. Krynskiy1,2, N. A. Hailov1, E. I. Dobrovolskaia1, N. A. Didkovsky2, D. P. Ogurtsov2, S. I. Gavrilova3, E. V. Ponomareva3, I. V. Kolyhalov3;
1
NRC “Kurchatov Instutute”, Moscow, Russian Federation, 2Science Research Institute of Physical-Chemical Medicine, Moscow, Russian Federation, 3Mental Health Research Center, Moscow, Russian
Federation.
J. Lee, G. Lee, N. Gu, J. Byeon, H. Kim, S. Cha;
H. T. Fuzii, G. A. Dias, G. T. Yoshikawa, R. V. Koyama, S. Fujihara, R. Medeiros, J. A. Quaresma;
Universidade Federal do Pará, Belém, Brazil.
S. Avdic1, B. P. McSharry1, M. Steain1, E. Poole2, J. Sinclair2, A. Abendroth1, B. Slobedman1;
1
The University of Sydney, Sydney, Australia, 2University of Cambridge, Cambridge, United Kingdom.
S. Ye1, S. Lowther2, J. Stambas1;
1
Deakin University, Waurn Ponds, Australia, 2CSIRO AAHL, Geelong, Australia.
M. Deplanche1, L. Alexeeva2, P. Germon3, P. Rainard3, F. Dessauge4, L. Finot4, Y. Le Loir1, D. G. Smith5, N. Berkova1;
INRA, Agrocampus Ouest, Rennes, France, 2Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation, 3INRA, Université François Rabelais de Tours, Nouzilly, France, 4INRA,
Saint Gilles, France, 5University of Glasgow, Institute of Infection, Glasgow, United Kingdom.
P.B.24.21
Neurological manifestations in patients with primary biliary cirrhosis(PBC)
P.B.24.22
Acute Toxoplasma gondii infection in Alzheimer’s disease
P.B.24.23
Investigation of the Response of the NF-κB Signalling Pathway of SK-Hep-1 Cells treated with Wild-Type and Mutant Pre-Ligand Assembly Domain
P.B.24.24
The features of immunopathogenesis at the metabolic syndrome from patients of Khakassia
P.B.24.25
The level of cytokines in patients with metabolic syndrome of the Republic of Khakassia
P.B.24.26
Assessment of T cell lineage-specific transcription factors and cytokines expression in multiple sclerosis and neuro-behçet disease patients
C. J. Kalliouli-Antonopoulou1, X. Koufomichali2, S. Kokkoris2, M. Agrogianni2, A. Ioannidou2, L. Karasavidou2, E. Pappa1, C. Drakoulis2;
1
Department of Immunology, General State Hospital of Nikea-Piraeus “Agios Panteleimon”, Nikea-Piraeus, Greece, 22nd Department of Internal Medicine, General State Hospital of Nikea-Piraeus “Agios
Panteleimon, Nikea-Piraeus, Greece.
R. C. Montacute, S. Cruickshank, S. M. Allan;
University of Manchester, Manchester, United Kingdom.
Tuesday
1
S. Albogami, O. Negm, I. Todd, L. Fairclough, P. Tighe;
E. S. Ageeva, O. Y. Kilina, O. V. Shtygasheva;
Khakas State University, Abakan, Russian Federation.
E. S. Ageeva, Y. V. Saranchina, O. V. Shtygasheva, O. Y. Kilina, A. A. Afanasyeva;
Khakas State University, Abakan, Russian Federation.
M. Belghith1, k. Bahrini1, M. Kchaou2, S. Belal2, M. R. Barbouche1;
1
Pasteur Institut, Tunis, Tunisia, 2Charles Nicolle Hospital, Tunis, Tunisia.
Chairpersons: Martina Prelog; Innsbruck, Austria / Revaz I. Sepiashvili; Moscow, Russian Federation (tbc)
P.B.25.01
Differences of molecular sensitization profile towards animal and pollen allergens revealed by allergen micro-array in two generations of patients with respiratory
allergy
V. Garib1,2, E. Wollmann1, G. Djambekova1, G. Hudoyarova1, F. Gastager2, R. Valenta1,2;
1
Div. of Immunopathology, Dept. of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria, 2International Network f of Universities or Molecular Allergology and Immunology,
Vienna, Austria.
P.B.25.02
Molecular sensitization profiles to grass pollen allergens in Central Asia revealed with micro-arrayed allergens
P.B.25.03
Mapping IgE epitopes of food allergens which cross-react with the major birch pollen allergen, Bet v 1
P.B.25.04
Cloning, expression in insect cells and immunological characterization of Par j 2.0101, a major allergen of Parietaria judaica pollen
P.B.25.05
Role of 8-oxoG in pollen-induced allergic airway inflammation
P.B.25.06
Non specific lipid transfer proteins - are they really unspecific
P.B.25.07
Recombinant expression, characterization and epitope mapping of gamma gliadins as major allergens in IgE-mediated wheat food allergy
P.B.25.08
Identification and characterization of natural adjuvants in birch pollen
P.B.25.09
Mouse lung-specific initiation of allergic asthma ignorome
P.B.25.10
Proanthocyanidins from the bark of Metasequoia glyptostroboides ameliorate allergic contact dermatitis through directly inhibiting T cells activation and Th1/Th17
responses
V. Garib, E. Wollmann, G. Djambekova, R. Valenta;
Div. of Immunopathology, Dept. of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
M. A. A. Kodydek, K. Hoffmann-Sommergruber, R. Valenta, M. Focke-Tejkl;
Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
Y. Dorofeeva, M. Asumta Anyango Kodydek, R. Valenta, M. Focke-Tejkl;
Medical university of Vienna, Wien, Austria.
K. L. Pázmándi1, A. Varga1, I. Boldogh2, É. Rajnavölgyi1, T. Bíró1, A. Bácsi1;
1
Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, 2Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston,
TX, United States.
P. Dubiela, P. Humeniuk, S. Pfeifer, M. Bublin, K. Hoffmann-Sommergruber;
Department of Pathophysiology and Allergy Research, Vienna, Austria.
S. Pahr1,2, A. Baar1,2, B. Srinivasan1, N. Papadopoulos3, S. Giavi4, M. Mäkelä5, A. Pelkonen5, C. Ebner6, J. Thalhamer7, S. Vrtala1,2, R. Valenta1;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Christian
Doppler Laboratory for the Development of Allergen Chips, Medical University of Vienna, Vienna, Austria, 3Allergy Department, 2nd Pediatric Clinic, University of Athen, Athen, Greece, 4Allergy Department,
2nd Pediatric Clinic, University of Athen, Athens, Greece, 5Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland, 6Ambulatory for Allergy and Clinical Immunology Vienna, Vienna,
Austria, 7Department of Molecular Biology, Division of Allergy and Immunology, University of Salzburg,, Salzburg, Austria.
D. Werner1,2, N. Zulehner1,2, B. Nagl1, G. J. Zlabinger3, B. Bohle1,2;
1
Institute of Pathophysiology and Allergy, Medical University Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Immunomodulation, Vienna, Austria, 3Institute of Immunology, Medical University
Vienna, Vienna, Austria.
M. Riba1, J. Garcia Manteiga1, B. Bosnjak2, D. Cittaro1, P. Mikolka2,3, C. Le2, M. M. Epstein2, E. Stupka1,4;
1
Center for Translational Genomics and Bioinformatics, San Raffaele Scientific Institute, Milan, Italy, 2Experimental Allergy, Department of Dermatology, Medical University of Vienna, Vienna, Austria,
3
Comenius University in Bratislava, Institute of Physiology (Jessenius Faculty of Medicine), Bratislava, Slovakia, 4Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riss, Germany.
F. Chen, X. Ye, Y. Yang, T. Teng, X. Li, S. Xu, Y. Ye;
Zhejiang Academy of Medical Sciences, Hangzhou, China.
P.B.25.11
Autoantibody reactivity in patients with allergic diseases, comobordity or distinct entities
E. N. Sibanda;
Asthma, Allergy and Immunology Clinic, Harare, Zimbabwe.
63
Tuesday
P.B.25.12
Epicutaneous allergen application induces allergen-specific IgG and T cell responses but not boosts of IgE production
P.B.25.13
Hymenoptera venoms multi-sensitization in Brazilian patients
P.B.25.14
Th1/Th2 cytokine profiles in sera and mononuclear cell’s supernatants in mono- and polysensitization
P.B.25.15
Analysis of the inflammatory and allergic properties of moulds
P.B.25.17
Allergic asthma increases the susceptibility of mice to Brucella melitensis after intranasal infection
P.B.25.18
Do mast cells contribute to the development of house dust mite-induced allergic airway inflammation in mice?
P.B.25.19
Stem cell factor and Interleukin-31 expression: Association with serum Immunoglobulin E antibody among atopic and non-atopic Egyptian patients with Bronchial
Asthma
R. Campana1, K. Moritz2, A. Neubauer3, H. Huber3, R. Henning3, K. Blatt4, G. Hoermann5, T. Brodie6, A. Kaider7, P. Valent4, F. Sallusto6, S. Wöhrl2, R. Valenta1;
1
Division of Immunopathology, Center of Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria, 2Division of Immunology, Department of Dermatology, Allergy and Infectious
Diseases, Medical University of Vienna, Vienna, Austria, 3Biomay AG, Vienna, Austria, 4Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna,
Vienna, Austria, 5Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria, 6Cellular Immunology Laboratory, Institute for Research in Biomedicine, Bellinzona, Switzerland,
7
Center for Medical Statistics, Informatics and Intelligent Systems, Section for Clinical Biometrics, Medical University of Vienna, Vienna, Austria.
K. M. De Amicis1,2, A. S. Watanabe1, C. E. Galvao1, D. D. Figo1, J. A. Santos-Pinto3, M. S. Palma3, F. Castro1, J. Kalil1, F. Ferreira-Briza2, G. Gadermaier2, K. S. Santos1;
1
University of Sao Paulo, Sao Paulo, Brazil, 2University of Salzburg, Salzburg, Austria, 3UNESP, Sao Paulo, Brazil.
H. Janaeva1, N. Riger2;
1
Clinical center “Planet of Health”, Urus-Martan, Russian Federation, 2Institute of Nutrition, Moscow, Russian Federation.
P. Lehebel, M. Vincent, S. De Prins, G. Tima, G. Treutens, K. Huygen, O. Denis;
Public Health Institute, Bruxelles, Belgium.
A. Machelart1, G. Potemberg1, F. Bureau2, J. Letesson1, E. Muraille1,3;
1
University of Namur, Namur, Belgium, 2University of Liège, Liège, Belgium, 3Université Libre de Bruxelles, Bruxelles, Belgium.
E. Mendez-Enriquez1, A. Westin1, T. B. Feyerabend2, H. Rodewald2, J. Hallgren1;
1
Uppsala University, Uppsala Biomedical Center, Uppsala, Sweden, 2Division for Cellular Immunology, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
M. Moaaz;
Medical Research Institute, Alexandria University, Alexandria, Egypt.
P.B.25.20
Interaction of fish and peanut allergens with intestinal and bronchial epithelial cells
P.B.25.21
Serum albumin - an important allergen also in processed meat products
P.B.25.22
Staphylococcus aureus derived protease induces Th2 driven airway inflammation in mice
P.B.25.23
Sensitivity and specificity of lymphocyte transformation test in assessment of hypersensitivity reactions following anticonvulsant usage
T. Kalic1, C. Palladino1, I. Ellinger1, E. Waltl2, K. Ashjaei1, V. Niederberger2, H. Breiteneder1;
1
Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria, 2Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
P. Román-Carrasco1, C. Klug1, G. Augustin1, S. Quirce2, I. Swoboda1, W. Hemmer3;
1
FH Campus Wien, Vienna, Austria, 2Department of Allergy, Hospital La Paz, Madrid, Spain, 3FAZ-Floridsdorf Allergy Center, Vienna, Austria.
A. R. Teufelberger1,2, S. Stentzel3, T. Maes4, G. Holtappels1, K. De Grove4, D. V. Krysko2, B. Bröker3, C. Bachert1, O. Krysko1;
1
Upper Airways Research Laboratory, Ghent University, Ghent, Belgium, 2Inflammation Research Center, Vlaams Instituut voor Biotechnologie, Ghent University, Ghent, Belgium, 3Department of
Immunology, University Medicine Greifswald, Greifswald, Germany, 4Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University, Ghent, Belgium.
M. Mesdaghi1, Z. Karami2, Z. Chavoshzadeh1, M. Mansouri1, P. Karimzadeh3;
1
Department of immunology, Mofid children’s hospital, Shahid university of medical sciences, Tehran, Iran, Islamic Republic of, 2Department of immunology, School of medicine, Shahid university of medical
sciences, Tehran, Iran, Islamic Republic of, 3Department of pediatric neurology, Mofid children’s hospital, Shahid university of medical sciences, Tehran, Iran, Islamic Republic of.
Chairpersons: Hans Grönlund; Stockholm, Sweden / Michelle M. Epstein; Vienna, Austria
P.B.26.01
In vitro studies of a novel, potent and selective PI3Kδ inhibitor: CPL-302-266
P.B.26.02
Preconception immunization with OVA can influence offspring thymic γδT cells maturation down-regulating IL-17 production
P.B.26.03
Isolation and characterization of SSEA-1+ pulmonary stem/progenitor cells for treatment of allergic asthma
P. Turowski1, A. Bujak1,2, M. Sekular1, M. Dziachan1, M. Zagozda1, M. Wieczorek1, P. Gunerka1,3;
1
Innovative Drugs R&D Department, Celon Pharma S.A, Kielpin/Lomianki, Poland, 2Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland, 3Department of Medical
Biotechnology, Medical University of Lodz, Lodz, Poland.
M. G. de-Oliveira, F. R. Sgnotto, A. J. Duarte, M. N. Sato, J. R. Victor;
Laboratory of Medical Investigation LIM 56, São Paulo, Brazil.
C. Chiu1, B. Chiang1,2;
1
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, 2Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
P.B.26.04 Delayed type hypersensitivity reactions to subcutaneously applied anticoagulants
K. Syre´, A. Zbyszewski, T. Kinaciyan;
DIAID, Dept. of Dermatology, Medical University of Vienna, Vienna, Austria.
P.B.26.05
The role of GSTM1 and GSTT1 gene polymorphisms in bronchial asthma
M. Castro1, A. Matos2, M. Lourenço2, J. Ferreira2, M. Bicho2;
Immunoallery Department-CHLN, Lisbon, Portugal, 2Genetic Department, Lisbon Medical School, Lisbon, Portugal.
1
P.B.26.06 Inducible nitric oxide synthase polymorphism in asthmatic patients
M. Castro1, A. Matos2, R. Prabhudas2, F. Joana2, A. Gil2, M. Bicho2;
1
ImmunoAllergy Department-CHLN, Lisbon, Portugal, 2Genetic Department, Lisbon Medical School, Lisbon, Portugal.
P.B.26.07
The role of Lelp-1 polymorphism in asthmatic patients
M. Castro1, M. Westerling2, A. Matos2, A. Gil2, J. Ferreira2, M. Bicho2;
1
ImmunoAllergy Department-CHLN, Lisbon, Portugal, 2Genetic Department, Lisbon Medical School, Lisbon, Portugal.
P.B.26.08 The role of myeloperoxidase gene promoter region polymorphism in asthma
M. Castro1, A. Matos2, R. Prabhudas,2, J. Ferreira2, A. Gil2, M. Bicho2;
1
ImmunoAllergy Department-CHLN, Lisbon, Portugal, 2Genetic Department; Lisbon Medical School, Lisbon, Portugal.
P.B.26.09 The role of methylenetetrahydrofolate reductase polymorphism in asthmatic patients
M. Castro1, M. Westerling2, A. Matos2, A. Gil2, J. Ferreira2, M. Bicho2;
1
ImmunoAllergy Department-CHLN, Lisbon, Portugal, 2Genetic Department; Lisbon Medical School, Lisbon, Portugal.
64
P.B.26.10
Substance P alleviates the symptoms of TNCB-induced allergic contact dermatitis in NC/Nga transgenic mice
P.B.26.11
Differential expression of Toso in moderate/severe and mild persistent allergic rhinitis and their possible correlation with clinical characteristics
P.B.26.12
Lipids from peanut reduce Ara h 1-induced TNF-α production in MoDCs of donors without peanut allergy
P.B.26.13
Transcriptome profile of the maturing murine lung and susceptibility for allergic airway disease
H. Choi1, M. K. Shin2, E. Chung1, Y. Son1,3;
1
Department of Genetic Engineering, College of Life Science and Graduate School of Biotechnology, Yong In, Seoul, Korea, Republic of, 2Department of Dermatology, Kyung Hee University Hospital, Seoul,
Korea, Republic of, 3Kyung Hee Institute of Regenerative Medicine, Seoul, Korea, Republic of.
A. Pirayesh, H. Shirzad, S. shahsavan;
Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran, Shahrekord, Iran, Islamic Republic of.
C. Palladino1, B. Gepp1, S. Sirvent2, A. Angelina2, M. Bublin1, C. Radauer1, N. Lengger1, T. Eiwegger3, O. Palomares2, H. Breiteneder1;
1
Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria, 2Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University of
Madrid, Madrid, Spain, 3Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
R. M. Grychtol, R. Sherburn, J. Vasiliou, A. Filia, M. Lovett, S. Saglani, C. Lloyd;
Imperial College, London, London, United Kingdom.
Chairpersons: Erhard Hofer; Vienna, Austria / Jose M. Martin-Villa; Madrid, Spain
P.B.27.01
Isolation and characterization of lymphocytes and fibroblasts from the skin of mycosis fungoides patients
P.B.27.02
Rapid dissemination of RET-transgene driven melanoma in the presence of Non-Obese Diabetic alleles : critical roles of Dectin-1 and Nitric-Oxide Synthase type 2
P.B.27.03
Regulatory T cells and myeloid-derived suppressor cells in patients with peptic ulcer and gastric cancer
P.B.27.04
Evaluation of the cytotoxic activities of CD8+ T Lymphocytes and NK cells in patients with non-small cell lung cancer
B. Beksaç1,2, G. Gunaydin2, D. Guc2;
1
Gazi University Faculty of Medicine Department of Dermatology, Ankara, Turkey, 2Hacettepe University Cancer Institute Department of Basic Oncology, Ankara, Turkey.
E. Dabbeche1,2, L. Krause1,2, M. Kato3, A. Prévost-Blondel1, H. J. Garchon1,2;
1
Cochin Institute, University Paris Descartes, INSERM U1016, Paris, France, 2University of Versailles Saint-Quentin, INSERM U1173, Montigny-le-Bretonneux, France, 3Unit of Environmental Health
Sciences, Chubu University, Aichi, Japan.
A. Ajami1,2, M. Tehrani1, H. Mesali1, Z. Rajabian1, V. Hosseini1;
1
Mazandarn University of Medical Sciences, Sari, Iran, Islamic Republic of, 2Molecular and Cell Biology Research Center, Sari, Iran, Islamic Republic of.
B. Eryasar1, E. Cetin Aktas1, U. Kucuksezer1, N. Akdeniz1, A. Yilmaz1, A. Turna2, G. Deniz1;
Istanbul University, The Institute of Experimental Medicine (DETAE), Department of Immunology, Istanbul, Turkey, 2Istanbul University, Cerrahpasa Medical School, Department of Thoracic Surgery,
Istanbul, Turkey.
1
P.B.27.05
Natural killer (NK) cells in tumor microenvironment inhibit the differentiation of Th1 and Th17
P.B.27.06
A low NK cell count and a high percentage of CD8+CD38+ cells are peripheral blood markers of PTLD
P.B.27.07
Histamine plus IL-2 induces expansion of activated CD56bright NK cells during maintenance therapy in acute myeloid leukemia
P.B.27.08
Enhanced NK cell-dependent surveillance of tumors in NKG2D-deficient mice
P.B.27.09
Imaging-based TVA™ measurements of natural killer cell activity provides results comparable to classic chromium release assays but without radioactivity, using
fewer cells, and with less labor
V. Morel1, S. Choquet1, M. Moussali2, I. Mauger3, C. Lebbe4, C. Frances5, V. Leblond3, B. Autran1, G. Carcelain1, A. Guihot1;
1
INSERMU1135, Paris, France, 2AP-HP Pitié Salpetriere, Paris, France, 3AP-HP, Pitié Salpetriere, Paris, France, 4AP-HP, hôpital St. Louis, Paris, France, 5AP-HP, hôpital Tenon, Paris, France.
A. Cuapio1, M. Post1, M. Osl1, S. Cerny-Reiterer2, K. V. Gleixner2, W. R. Sperr2,3, S. Herndlhofer2,3, P. Valent2,3, E. Hofer1;
1
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria, 2Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University
of Vienna, Vienna, Austria, 3Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria.
Tuesday
G. Lal, S. Paul;
National Centre for Cell Science, Pune, India.
V. Jelenčić, F. M. Wensveen, M. Lenartić, B. Polić;
School of medicine Rijeka, Rijeka, Croatia.
K. Horvath1, S. Sundararaman2, K. Karacsony2, D. Roen2, P. V. Lehmann2;
1
CTL Europe GmbH, Bonn, Germany, 2Cellular Technology Limited, Shaker Heights, OH, United States.
P.B.27.10
Invariant natural killer T cells impair the deleterious effect of B-1 lymphocytes on murine melanoma cells
P.B.27.11
Unconventional peripheral T-lymphocyte subsets in patients with oncology diseases and precancerous states
P.B.27.12
The potential immunomodulatory role of cortisol on NKG2D activating NK cells receptor in ovarian cancer
P.B.27.13
Low dose chemotherapy induces PD-L1 upregulation in tumors
P.B.27.15
Regulatory T cells showing phenotypical, epigenetic and functional features of immune suppression are enriched in human colorectal cancer
P.B.27.16
Dual role of transforming growth factor beta promoter polymorphism in colorectal cancer
P.B.27.17
Inducible regulatory T cells (Tr1) in the peripheral blood, lymph nodes and tumor tissues of patients with breast cancer
P.B.27.18
Upregulation of TRAIL-R2/DR5 by diclofenac sensitizes resistant melanoma to TRAIL-induced apoptosis
P.B.27.19
Interactions between NKT and regulatory T cells (Tregs) in patients with prostatic cancer and benign prostatic hyperplasia
P.B.27.20
The value of tumor infiltrating lymphocytes (TILs) as prognostic/predictive biomarkers in patients with breast cancer (BCa)
P.B.27.21
Role of tumor microenvironment in the development of cutaneous and ocular melanomas
P.B.27.23
Tumor-infiltrating T cells improve clinical outcome of therapy-resistant neuroblastoma
P.B.27.24
Timely vaccination with a MHC class II peptide attenuates CD8+ T cell tolerance in a mouse model of sporadic cancer
E. C. Perez1,2, M. F. Laurindo2, L. Osugi2, B. Vivanco2, J. Nogueira2, J. D. Lopes2, A. C. Keller2;
1
Universidade Paulista, São Paulo, Brazil, 2Universidade Federal de São Paulo, São Paulo, Brazil.
S. Penickova, L. Schandene, O. Pradier;
Hospital Erasme, Bruxelles, Belgium.
A. A. Seida;
Microbiology and Immunology Department, Faculty of Veterinary Medicine, Cairo University, Giza, P.O., Giza, Cairo, Egypt.
D. Quandt, B. Seliger;
University of Halle, Halle, Germany.
E. Timperi1, I. Pacella1, V. Schinzari1, L. Sacco2, F. Farelli2, F. Longo3, A. Ciardi4, P. Chirletti2, V. Barnaba1, S. Piconese1;
1
Sapienza Università di Roma, Dip. di medicina interna e specialità mediche, Italy, 2Sapienza Università di Roma, Sezione di Chirurgia interdisciplinare F. Durante, Italy, 3Sapienza Università di Roma, Dip. di
medicina molecolare, Italy, 4Sapienza Università di Roma, Dip. di Scienze Radiologiche e Oncologiche, Italy.
S. A. Stanilova1, L. Miteva1, G. Cirovski2, N. S. Stanilov3;
1
Trakia University, Medical Faculty, Department of Molecular Biology, Immunology and Medical genetics, Stara Zagora, Bulgaria, 2Trakia Hospital, Stara Zagora, Bulgaria, 3Trakia University, Medical
Faculty, Department of Surgery, Stara Zagora, Bulgaria.
F. Riazi-Rad1, Z. Saraf2, R. Omranipour3, M. H. Alimohammadian1, S. Ajdary1;
1
Pasteur institute of Iran, Tehran, Iran, Islamic Republic of, 2Tarbiat Modares University, Tehran, Iran, Islamic Republic of, 3Cancer Institute of Tehran University Of Medical Sciences, Tehran, Iran, Islamic
Republic of.
M. Vázquez-Strauss, G. Stingl;
Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Medical Universi, Vienna, Austria.
I. Mrakovcic-Sutic1, S. Sotosek2, V. Sotosek-Tokmadzic3, I. Sutic4, V. Pavisic5, M. Petkovic6;
1
Department of Physiology and Immunology, Medical Faculty, Rijeka, Croatia, 2Clinic of Urology, Clinical Hospital Centre Rijeka, Rijeka, Croatia, 3Department of Anaesthesiology, Reanimatology and
Intensive Care, Medical Faculty, Rijeka, Croatia, 4Department of Family Medicine, Medical Faculty, Rijeka, Croatia, 5Medical Faculty, Rijeka, Croatia, 6Department of Oncology and Radiotherapy, Medical
Faculty, Rijeka, Croatia.
S. P. Fortis1, C. Haritos1, M. Sofopoulos2, N. N. Sotiriadou2, N. Anastasopoulos1, M. Papamichail1, S. A. Perez1, C. N. Baxevanis1;
1
Cancer Immunology and Immunotherapy Center, Saint Savas Cancer Hospital, Athens, Greece, 2Saint Savas Cancer Hospital, Pathology Department, Athens, Greece.
J. R. de Carvalho1, A. Lallo1, J. G. Xavier1, L. Bonamin1, F. T. Konno1, J. D. Lopes2, E. C. Perez1,2;
1
Universidade Paulista, São Paulo, Brazil, 2Universidade Federal de São Paulo, São Paulo, Brazil.
M. Mina1, R. Boldrini2, A. Citti2, P. Romania2, V. D’Alicandro2, M. De Ioris2, A. Castellano2, C. Furlanello1, F. Locatelli2, D. Fruci2;
1
Fondazione Bruno Kessler, Trento, Italy, 2Ospedale Pediatrico Bambino Gesù, Rome, Italy.
C. Schön1, T. Blankenstein1,2, G. Willimsky1,2;
1
Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
P.B.28 Tumormarkers
Chairpersons: Paul A. Beavis; Melbourne, Australia / Dmitry Kuprash; Moscow, Russian Federation
P.B.28.01
1068 G>A and 1513A>C Polymorphisms in the P2X7 Receptor Gene in lymphoma Patients
A. Al-Shukaili1, A. Al-Ansari2, I. Burney3;
1
Health & Social Development Sector, The Research Council, Muscat, Oman, 2Department of Biology, College of Science, Sultan Qaboos University, (SQU ), Muscat, Oman, 3Oncology Unit, Department of
Medicine, College of Medicine &Health Sciences, SQU, Muscat, Oman.
65
P.B.28.02
CXCL8 as candidate biomarker for detecting metastatic processes in cutaneous melanoma
P.B.28.03
Evaluation of systemic and local levels of nitric oxide in Algerian breast cancer patients: correlation with clinico-pathological parameters
M. Neagu1,2, C. Constantin1, D. Boda3, S. Zurac3,4;
1
Victor Babes National Institute of Pathology, Bucharest, Romania, 2University of Bucharest, Bucharest, Romania, 3“Carol Davila” University of Medicine & Pharmacy, Bucharest, Romania, 4Colentina
University Hospital, Bucharest, Romania.
M. Amri1, A. Lekehal1, R. Miloudi1, N. Benzidane2, A. Kouchkar3, N. Terki3, C. Touil-Boukoffa1;
1
Team “Cytokines and NOSynthases”, laboratory of cellular and molecular biology, faculty of biological sciences, university of science and technology Houari Boumediene, Algiers, Algeria, 2Department of
senology, Centre Pierre and Marie Curie, Algiers, Algeria, 3Department of anatomic-pathology, Centre Pierre and Marie Curie, Algiers, Algeria.
P.B.28.04 Estrogen activates protein kinase CK2 via ROS generation
S. Im, S. Jung, H. Bang;
Dept. of Biological Sciences, Chonnam National University, Gwangju, Korea, Republic of.
P.B.28.05
Clinical importance of S100A9 and S100A2 in breast cancer
M. Günaldı1, Y. Okuturlar2, A. Kural3, C. Akarsu4, M. Karabulut4, A. Gedikbaşı3;
1
Bakırköy Dr Sadi Konuk Research and Training Hospital,Medical Oncology, Istanbul, Turkey, 2Bakırköy Dr Sadi Konuk Research and Training Hospital,Internal Medicine, Istanbul, Turkey, 3Bakırköy Dr Sadi
Konuk Research and Training Hospital,Department of Biochemistry, Istanbul, Turkey, 4Bakırköy Dr Sadi Konuk Research and Training Hospital,General Surgery, Istanbul, Turkey.
P.B.28.06 KRAS and BRAF status in colorectal cancer from Algerian Patients
K. Berkane1, S. Ait-Younes2, K. Bouzid1;
1
Molecular & Medical Oncology Pierre & Marie Curie Center, Hospital Mustapha, University Algiers 1, Algiers, Algeria, 2Pathology Department Pierre & Marie Curie Center, Algiers, Algeria.
P.B.28.07
Clinical significance of serum survivin in cancer patients
Tuesday
M. Gunaldi1, N. Isiksacan1, Y. Okuturlar1, H. Kocoglu1, O. Gunaldi2;
1
Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey, 2Bakirkoy Mental and Neurological Diseases Education and Training Hospital, Istanbul, Turkey.
P.B.28.08 Investigation of tumor-associated carbonic anhydrase XII expression in cancer cells
D. Dekaminaviciute, R. Lasickiene, A. Vaitiekaite, P. Andrejauskas, V. Petrikaite, D. Matulis, A. Zvirbliene;
Institute of Biotechnology, Vilnius University, Vilnius, Lithuania.
P.B.28.09 NFkB-dependent regulation of chemokine receptor CXCR5 gene by p53 family of tumor suppressors in MCF-7 breast cancer cells
N. A. Mitkin1, A. M. Muratova1,2, A. M. Schwartz1, C. D. Hook1, S. Biswas3, M. A. Afanasyeva1, A. Bhattacharyya3, D. V. Kuprash1,2;
1
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation, 2Department of Immunology, Faculty of Biology, Lomonosov Moscow State University, Moscow,
Russian Federation, 3Department of Zoology, University of Calcutta, Calcutta, India.
P.B.28.10
Enhanced detection and quantification of circulating tumor cells using Imaging Flow Cytometry
P.B.28.11
Serum auto-antibody against calreticulin as a potential biomarker for detection of colorectal cancer
P.B.28.12
Anti-retinol binding protein 1 auto-antibody is a tumor biomarker for advanced stages of colorectal cancer
P.B.28.13
Negative association of the HLA-DQB1*02 allele with breast cancer development among Jordanians
P.B.28.14
Phosphatidylethanolamine-binding protein 4 is associated with breast cancer metastasis through Src-mediated Akt tyrosine phosphorylation
P.B.28.15
The study of relationship between ERK1/2 and p38 MAPK signal pathway and LOX expression in gastric cancer cells
S. Vaidyanathan1, D. Weldon2, P. Rhein3, D. A. Basiji1, P. Morrissey1;
1
Amnis part of EMD Millipore, Seattle, WA, United States, 2EMD Millipore, Hayward, CA, United States, 3Merck Chemicals GmbH, Schwalbach, Germany.
G. Ghalamfarsa1, M. Mahmoudi2, S. Hosseini3, A. Ghaderi4, Z. Mojtahedi4;
1
Cellular & Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran, Islamic Republic of, 2Immunology Research Center, Department of Immunology and Allergy, School of Medicine,
Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of, 3Department of Colorectal Surgery, Colorectal Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz,
Iran, Islamic Republic of, 4Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of.
F. Jadidi-Niaragh1,2,3, G. Ghalamfarsa4, M. Mahmoudi5, S. Hosseini6, A. Ghaderi7, Z. Mojtahedi7;
1
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 2Immunology Research Center, Tabriz University of Medical Sciences, Tabriz,
Iran, Islamic Republic of, 3Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of, 4Cellular & Molecular Research Center, Yasuj University
of Medical Sciences, Yasuj, Iran, Islamic Republic of, 5Immunology Research Center, Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,
Islamic Republic of, 6Department of Colorectal Surgery, Colorectal Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of, 7Shiraz Institute for Cancer
Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of.
M. F. Atoum, R. Tanashat, S. Alhaj mahmoud;
Hashemite University, Zarqa, Jordan.
T. Zhang1, H. Li2, X. Wang3;
1
Second affiliated hospitial, ZheJiang Universitity school of medicine, HangZhou, China, 2The Tumor Hospital of Zhejiang Province, HangZhou, China, 3Immunology institution, ZheJiang Universitity school
of medicine, HangZhou, China.
M. Han1, R. Liu2;
1
Ningxia Medical University, Yinchuan, China, 2General hospital, Ningxia Medical University, Yinchuan, China.
P.B.28.16 MHC-I and matrix metalloproteinase 9 immunodetection in mammary tumors of dogs
A. Matsui, P. R. Moreira, R. O. Vasconcelos;
Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil.
P.B.28.17
miRNAs in Sera of Tunisian patients discriminate between inflammatory breast cancer and non-inflammatory breast cancer
R. Marrakchi1, K. Hamdi1, D. Goerlitz2, J. Blancato2, M. Islam2, A. Ben Ammar Elgaaied11;
1
Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences, University of Tunis El, Tunis, Tunisia, 2Lombardi Comprehensive Cancer Center, Georgetown University Medical Center,
Washington, WA, United States.
P.B.28.18 The development of an angiogenic protein signature in ovarian cancer ascites as a tool for biologic and prognostic profiling
N. G. Gavalas1, S. Trachana1, E. Pilalis2, K. Tzannis1, O. Papadodima2, M. Liontos1, A. Chatziioannou2, M. A. Dimopoulos1, A. Bamias1;
1
University of Athens, Medical School, Athens, Greece, 2Metabolic Engineering and Bioinformatics Program Institute of Biology, Medical Chemistry & Biotechnology, National Hellenic Research Foundation,
Athens, Greece.
P.B.28.20
Could loss of CD5 on T-lymphocytes characterize ongoing immunopathology and malignant processes ?
P.B.28.21
Gene expression profiling of circulating tumor cells and peripheral blood mononuclear cells from breast cancer patients
P.B.28.22
YKL-40 and colorectal cancer - is there a link?
S. Penickova, L. Schandene, O. Pradier;
Hospital Erasme, Bruxelles, Belgium.
M. Hensler;
SOTIO, Prague, Czech Republic.
M. Kazakova1, Y. Feodorova1, K. Simitchiev2, G. Kostov3, R. Dimov4, V. Sarafian1;
1
Medical University - Plovdiv, Department of Medical Biology, Plovdiv, Bulgaria, 2University of Plovdiv, Bulgaria, Faculty of Chemistry, Department of Analytical Chemistry and Computer Chemistry,
Plovdiv, Bulgaria, 3Medical University - Plovdiv, Clinic of Surgery, Hospital “Kaspela” – Plovdiv, Bulgaria, Plovdiv, Bulgaria, 4Medical University - Plovdiv, Department of Special Surgery, Plovdiv, Bulgaria.
Chairpersons: Peter Pietschmann; Vienna, Austria / Ihsan Gursel; Ankara, Turkey (tbc)
P.C.09.01
Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence
R. Joulia1, N. Gaudenzio2, M. Rodrigues1, J. Lopez1, N. Blanchard1, S. Valitutti1, E. Espinosa1;
INSERM CPTP, Toulouse, France, 2School of Medicine, Department of Pathology, Stanford, Stanford, CA, United States.
1
66
P.C.09.02
The role of mast cell tryptases in allergic airways disease
P.C.09.03
Mast cells migration in mechanism of delayed-type hypersensitivity reaction
P.C.09.04
Cytochemical characteristics of human thymic mast cells
P.C.09.05
Negative regulatory roles of ORMDL3 in the FcεRI-triggered expression of proinflammatory mediators, chemotactic response, and passive cutaneous anaphylaxis
A. Essilfie1, A. Jarnicki1, S. Gellatly1, A. Brown1, A. Deane1, K. Budden1, R. Stevens2, P. Hansbro1;
1
University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia, 2Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States.
T. V. Sydorenko, L. A. Dyugovska, O. F. Melnikov;
Institute of Otolaryngology, Kyiv, Ukraine.
V. V. Guselnikova;
St. Petersburg State University, St. Petersburg, Russian Federation.
V. Bugajev, I. Halova, L. Draberova, M. Bambouskova, L. Potuckova, H. Draberova, T. Paulenda, S. Junyent, P. Draber;
Institute of Molecular Genetics, Prague, Czech Republic.
P.C.09.06 The reaction of population pulmonary mast cells under the action of β-blockers on the rat’s asthma model
M. Syrtsova;
Institute of Experimental Medicine, St. Petersburg, Russian Federation.
P.C.09.07
Epigenetic regulation of keratinocyte derived antimicrobial peptides during skin development
T. Berger, L. Beer, A. Elbe-Bürger, E. Tschachler, M. Mildner;
Medical University of Vienna, Department of Dermatology, Wien, Austria.
G. M. Aleshina, I. A. Yankelevich, V. N. Kokryakov;
Institute of Experimental Medicine, Saint Petersburg, Russian Federation.
P.C.09.09 A pilot investigation: Inflammatory and oxidative pathways in isolated peripheral mononuclear cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
patients
T. Nguyen;
Menzies Health Institution, Gold Coast, Australia.
P.C.09.11
Keratinocytes and their participation on innate immunity against dengue virus
P.C.09.12
Modulation of dendritic cells by exosomes derived from human breast milk and plasma
P.C.09.13
Non-toxic concentrations of graphene quantum dots exhibit anti-proliferative, anti-inflammatory and immunoregulatory properties in a model of human
peripheral blood mononuclear cells
M. López-González1,2, J. Garcia-Cordero1, L. Cedillo-Barron1;
1
Pasteur Institute, Paris, France, 2CINVESTAV, México D.F., Mexico.
Tuesday
P.C.09.08 Immunomodulating effect of antimicrobial peptide defensin RatNP3
M. Eldh, P. Larssen, S. Gabrielsson;
Karolinska Institutet, Department of Medicine, Translational Immunology Unit, Stockholm, Sweden.
D. Mihajlovic1, S. Tomic1, Z. Markovic2, V. Trajkovic3, M. Colic1;
1
Medical Faculty of the Military Medical Academy, University of Defence, Belgrade, Serbia, 2Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia, 3Institute for Microbiology and
Immunology, School of Medicine, University of Belgrade, Belgrade, Serbia.
P.C.09.14
IDO1 deficiency does not affect disease in systemic juvenile idiopathic arthritis and hemophagocytic lymphohistiocytosis mouse models
P.C.09.15
Anti-inflammation of amide compounds in LPS-induced human gingival fibroblasts
P.C.09.16
PTX3 is involved in the regulation of bone mass in physiological and pathological conditions
P.C.09.17
Role of inflammation induced by the serine-protease granzyme A in development of colorectal carcinoma in vivo
P.C.09.18
Malondialdehyde adducts constitute metabolic danger signals in vitro and in vivo
P.C.09.19
Lactobacillus rhamnosus GG regulates T cell proliferation and differentiation by inducing prostaglandin E2 and vascular endothelial growth factor α from gut
dendritic cells
K. Put1, E. Brisse1, A. Avau1, M. Imbrechts1, T. Mitera1, F. Fallarino2, C. Wouters3, P. Matthys1;
1
Laboratory of Immunobiology, KU Leuven, Leuven, Belgium, 2Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, 3Laboratory of Pediatric Immunology,
University Hospital Leuven, KU Leuven, Leuven, Belgium.
N. Aroonrerk1, N. Niyomtham2, B. Yingyoungnarongkul2;
1
Department of Stomatology, Faculty of Dentistry, Srinakharinwirot University, Bangkok, Thailand, 2Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand.
D. Grcevic1, T. Kelava1, V. Katavic1, S. Ivcevic1, N. Kovacic1, M. Sironi2, S. Valentino2, H. Cvija1, L. Deban2, B. Bottazzi2;
1
University of Zagreb School of Medicine, Zagreb, Croatia, 2Humanitas Clinical and Research Center, Rozzano (Milan), Italy.
L. Santiago1, M. Castro2, M. Arias1, M. Bernal3, P. Sota4, G. Muñoz4, M. Domper5, A. Alcalde2, A. Fernández5, J. Pardo1,6,7;
1
Centro de Investigación Biomédica de Aragón (CIBA), IIS Aragon/Universidad de Zaragoza, Zaragoza, Spain, 2Departamento de Fisiologia, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza,
Spain, 3Servicio de Bioquímica, Hospital Clínico Universitario Lozano Blesa, IIS Aragon/ Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain, 4Servicio de Anatomia Patologica, Hospital
CLinico Universitario Lozano Blesa, IIS Aragon/Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain, 5Servicio de Aparato Digestivo, Hospital CLinico Universitario Lozano Blesa, IIS Aragon/
Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain, 6Instituto de Nanociencia de Aragon (INA), Zaragoza, Spain, 7Fundación Aragon I+D (ARAID), Zaragoza, Spain.
C. J. Busch1, D. Weismann1, T. Hendrikx1,2, V. Millischer1, G. Haas1, R. Shiri-Sverdlov2, C. J. Binder1;
1
Medical University of Vienna, Vienna, Austria, 2Maastricht University, Maastricht, Netherlands.
Z. Ye, C. Huang, K. Chua, I. Kuo;
National University of Singapore, Singapore, Singapore.
P.C.09.20
The effect of one bout eccentric exercise of elbow muscles on G-CSF ,Mb, MPO And PGE2
P.C.09.21
Intracellular signaling for platelet-activating factor (PAF) production in macrophages and high-throughput screening for a specific inhibitor for PAF synthetic
enzyme (LPCAT2)
F. Nameni1, H. Poursadra2;
1
varamin pishva branch, islamic azad university, Varamin, pishva, Iran, Islamic Republic of, 2Financial Management, Dustan Equipment, teran, Iran, Islamic Republic of.
R. Morimoto1,2, H. Shindou2,3, M. Tarui2, T. Shimizu1,2;
1
The University of Tokyo, Tokyo, Japan, 2National Center for Global health and Medicine, Tokyo, Japan, 3CREST, Saitama, Japan.
P.C.09.22
Targeting the sphingosine pathway to resolution of inflammatory response induced by LPS
P.C.09.23
Proresolving actions of synthetic and natural protease inhibitors are mediated by Annexin A1
P.C.09.24
Expression and role of the long Pentraxin PTX3 in lymphatic endothelial cells
P.C.09.25
Developing antibodies against chemerin using phage display technology
P.C.09.26
Selective expression of CCRL2 transcript variants associates with inflammatory response in breast cancer
D. Perez, R. Athayde, A. Reis, P. Menezes, L. Ribeiro, M. Teixeira, L. Sousa, V. Pinho;
UFMG, Belo Horizonte, Brazil.
J. P. Vago1,2,3, L. P. Tavares3, M. A. Sugimoto1,4, I. Galvão3, G. L. Lima1,3, T. R. Caux1,3, K. M. Lima1,2,3, A. C. Ribeiro1,3, F. S. Carneiro1,4, F. F. Nunes1, V. Pinho2,3, M. Perretti5, M. M. Teixeira3, L. P. Sousa1,2,3;
1
Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, 2Programa de Pós-Graduação em Biologia Celular, Universidade Federal de Minas Gerais,
Belo Horizonte, Brazil, 3Laboratório de Imunofarmacologia, Departamento de Bioquímica e Imunologia, Belo Horizonte, Brazil, 4Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de
Farmácia, Belo Horizonte, Brazil, 5William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, United Kingdom.
M. Sironi1, A. Doni1, S. Valentino1, M. Nebuloni2, F. Pasqualini1, A. Vecchi1, C. Garlanda1, B. Bottazzi1, A. Mantovani1,3;
1
Humanitas Research Hospital, Rozzano, Italy, 2University of Milano, Milano, Italy, 3Humanitas University, Rozzano, Italy.
S. Valaris1,2, D. R. Greaves1, M. Wright2;
1
Sir WIlliam Dunn School of Pathology, Oxford, United Kingdom, 2UCB Pharma, Slough, United Kingdom.
P. Sarmadi1, G. Tunali1, G. Esendagli-Yilmaz2, K. Yilmaz3, G. Esendagli1;
1
Hacettepe University Cancer Institute, Department of Basic Oncology, Ankara, Turkey, 2Department of Pathology, Medical Faculty, Gazi University, Ankara, Turkey, 3Department of General Surgery, Diskapi
Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
67
Chairpersons: Angela Santoni; Rome, Italy / Veronika Sexl; Vienna, Austria
P.C.10.01
LFA-1 activation in Natural Killer cells and their subsets
P.C.10.02
CD57 shades poly-functionality of Natural Killer cells during human aging
P.C.10.03
The structure of the atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4
P.C.10.04
Dimorphism of KIR3DL1 allotype recognition of HLA based on Bw4 motif subtype
P.C.10.05
CD56brightperforinlow non-cytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via
afferent lymph
D. Urlaub1, K. Kohl2, M. Müller2, C. Watzl1;
1
Leibniz Research Centre, IfADo, Dortmund, Germany, 2Institute for Immunology, University Heidelberg, Heidelberg, Germany.
H. Kared1, S. Martelli2,3, V. S. Chew4, T. Ng5, A. Larbi2;
1
Singapore Immnunology Network (SIgN), A*STAR, Singapore, Singapore, 2Singapore Immunology Network (SIgN), Aging and Immunity Program, Agency for Science Technology and Research (A*STAR),
Singapore, Singapore, 3Division of Infection, Inflammation, and Repair, School of Medicine, University of Southampton, Southampton, United Kingdom, 4Singhealth Translational Immunology and
Inflammation Centre (STIIC), DUKE-NUS, Singapore, Singapore, 5Gerontological Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
S. Moradi1, R. Berry1, P. Pymm1, C. Hitchen1, S. A. Beckham11, M. C. Wilce1, N. G. Walpole1, C. S. Clements1, H. H. Reid1, M. A. Perugini2, A. G. Brooks3, J. Rossjohn1, J. P. Vivian1;
1
Monash university, Clayton, Australia, 2La Trobe University, Melbourne, Australia, 3University of Melbourne, Parkville, Australia.
P. Pymm1, P. Saunders2, G. O’Connor2, J. Vivian1, D. McVicar3, A. Brooks2, J. Rossjohn1;
1
Monash University, Melbourne, Australia, 2University of Melbourne, Melbourne, Australia, 3National Cancer Institute, Frederick, MD, United States.
Tuesday
S. Campana1, I. Bonaccorsi1, E. Di Carlo2, L. Moretta3, G. Ferlazzo1, P. Carrega3;
1
Università degli studi di Messina, Messina, Italy, 2Fondazione Università “G. d’ Annunzio”, Chieti, Italy, 3Istituto Giannina Gaslini, Genova, Italy.
P.C.10.06
The role of tumor infiltrating and tumor associated natural killer cells in promotion of angiogenesis in colorectal cancer patients
P.C.10.07
Natural killer cells from malignant pleural effusions show a decidual-like, pro-angiogenic phenotype
P.C.10.08
NKG2C receptor in HCMV infection: Generation of a cellular model to identify the putative ligand
S. Zanellato1,2, A. Bruno3, B. Bassani3, L. Dominioni1, L. Boni1, E. Cassinotti1, G. David1, A. Albini4, L. Mortara2, D. M. Noonan2,2;
1
Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy, 2Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy, 3Scientific and Technology
Pole, IRCCS MultiMedica, Milano, Italy, 4Department of Research and Statistics Infrastructure, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
S. Zanellato1,2, A. Bruno3, M. Cattoni1, B. Bassani3, A. Imperatori1, L. Dominioni1, A. Albini4, D. M. Noonan2,3, L. Mortara2;
1
Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy, 2Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy, 3Scientific and Technology
Pole, IRCCS MultiMedica, Milano, Italy, 4Department of Research and Statistics Infrastructure, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
A. Pupuleku1, A. Muntasell2, M. López-Botet1,2;
Universitat Pompeu Fabra, Barcelona, Spain, 2Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain.
1
P.C.10.09
Novel non-canonical role of STAT1 in Natural Killer cell cytotoxicity
P.C.10.10
Effect of IL-1β-producing AML blasts on NK cell differentiation: implications in haplo-HSCT
P.C.10.11
Activated NKT cells imprint essential NK cell features
P.C.10.13
Phenotypic and functional characterization of the peripheral blood Natural Killer (NK) cells in Crohn disease patients
P.C.10.14
The regulation of NK cell detachment as a key factor for serial killing and NK cell effector function
P.C.10.15
NK cell licensing after double umbilical cord blood transplantation is driven by the self-HLA from the emerging cord blood
P.C.10.16
NK cell activation as a possible signature of the alarmin IL-33 released during kidney transplantation
P.C.10.17
Uptake of CCR7 by KIR2DS4+ NK cells is induced upon recognition of certain HLA-C alleles
P.C.10.18
Activation of human NK cells by Leishmania parasites occurs indirectly via monocyte-derived signals
P.C.10.19
CXCL7 secreted by NK cell leads to increased MSC recruitment
P.C.10.20
Multiple myeloma cell-derived exosomes: characterization and immunomodulatory role on NK cell-mediated functions
P.C.10.21
Differential requirements of activating and inhibitory Ly49 receptors in recognition of MCMV-infected cells
P.C.10.22
Effect of CMV seropositivity and ageing on the expression of activating NK receptors IL-2 activated NK cells
E. M. Putz1, D. Gotthardt1, A. Majoros2, M. Prchal-Murphy1, M. Müller1,3, C. Gerner4, T. Decker2, V. Sexl1;
1
University of Veterinary Medicine Vienna, Vienna, Austria, 2Max F. Perutz Laboratories, University of Vienna, Vienna, Austria, 3Biomodels Austria, Vienna, Austria, 4Faculty of Chemistry, University of Vienna,
Vienna, Austria.
C. Vitale1,2, P. Ambrosini3, F. Ballerini1,2, L. Moretta3, M. Mingari1,2;
1
Università degli Studi di Genova, Genova, Italy, 2IRCCS AOU San Martino-IST, Genova, Italy, 3IRCCS G.Gaslini, Genova, Italy.
S. Trittel1,2, B. J. Chambers2, L. Cicin-Sain1, C. A. Guzmán1, P. Riese1;
1
Helmholtz Centre for Infection Research, Braunschweig, Germany, 2Karolinska Institute, Stockholm, Sweden.
A. Ahmad, S. Samarani, P. Sagala, C. Deslandres, D. Amre;
CHU Ste-Justine/University of Montreal, Montreal, QC, Canada.
P. Netter1,2, M. Anft1, C. Watzl1;
1
IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany, 2Center for Human Immunobiology, Baylor College of Medicine Texas Children’s Hospital, Baylor College
of Medicine, Houston, TX, United States.
N. Guillaume1, P. Loiseau2, C. Retière3, K. Gagne3, G. Henry2, G. Socié4, J. Cayuela5, N. Dulphy2, A. Toubert2;
1
INSERM U1160 Hôpital Saint-Louis; EA 4666 CHU d’Amiens, Amiens, France, 2INSERM U1160; Université Paris Diderot Sorbonne Paris Cité; Laboratoire d’Immunologie, Hôpital Saint-Louis, AP-HP, Paris,
France, Paris, France, 3EFS Nantes, laboratoire EA4271, Nantes, France, 4INSERM U1160; Université Paris Diderot Sorbonne Paris Cité; Service d’Hématologie-Greffe de Moelle, Hôpital Saint-Louis, AP-HP,
Paris, France, Paris, France, 5Université Paris Diderot Sorbonne Paris Cité; Laboratoire d’Hématologie Biologique, Hôpital Saint-Louis, AP-HP, Paris, France.
M. Ferhat1,2, A. Robin1,3, S. Giraud1,3, M. Charron3,4, C. Giraud3,4, T. Hauet1,2,5, A. Herbelin1, J. Gombert1,2,6, A. Thierry1,7;
1
INSERM U1082, Poitiers, France, 2Faculté de Médecine et de Pharmacie. Université de Poitiers, Poitiers, France, 3CHU de Poitiers, Poitiers, France, 4Etablissement Français du sang (EFS), Poitiers, France,
5
Laboratoire de Biochimie, CHU de Poitiers, Poitiers, France, 6Laboratoire d’Immunologie, CHU de Poitiers, Poitiers, France, 7Service de Néphrologie-Hémodialyse-Transplantation rénale, CHU de Poitiers,
Poitiers, France.
S. Pesce1, S. Carlomagno1, A. Moretta1,2, S. Sivori1,2, E. Marcenaro1,2;
1
Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy, 2Centro di Eccellenza per le Ricerche Biomediche, Università degli Studi di Genova, Genova, Italy.
H. Meßlinger, U. Schleicher, C. Bogdan;
Microbiology Institute - University Hospital Erlangen, Erlangen, Germany.
C. R. Almeida1,2, D. P. Vasconcelos1,2,3, H. R. Caires1,2,3, M. A. Barbosa1,2,3;
1
INEB - Instituto de Engenharia Biomédica, Porto, Portugal, 2Instituto de Investigação e Inovação em Saúde, Porto, Portugal, 3ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Porto, Portugal.
A. Zingoni, E. Vulpis, F. Cecere, R. Molfetta, A. Soriani, C. Fionda, L. Masuelli, L. Simonelli, R. Paolini, M. Cippitelli, A. Santoni;
University, Rome, Italy.
J. Železnjak1, B. Popović1, V. Juranić Lisnić1,2, A. L’Hernault3, N. Trautwein4, M. Babić Čač1, B. Lisnić2, A. Halenius5, H. Hengel5, S. Stevanović4, L. Dolken3, A. Krmpotić1, S. Jonjić1,2;
1
Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Croatia, 2Center for Proteomics, Faculty of Medicine, University of Rijeka, Croatia, 3Department of Medicine, University
of Cambridge, United Kingdom, 4Department of Immunology, Interfaculty Institute for Cell Biology, University of Tübingen, Germany, 5Institute of Virology, Albert-Ludwigs-University, Freiburg, Germany.
N. López Sejas1, F. Hassouneh1, C. Campos1, A. Pera1, J. Gordillo2, R. Tarazona2, R. Solana1;
1
IMIBIC-HURS-UCO, Córdoba, Spain, 2Universidad de Extremadura, Cáceres, Spain.
Chairpersons: Gunnur Deniz; Istanbul, Turkey / Alberto Mantovani; Milan, Italy
P.C.11.01
68
Macrophage plasticity is mediated by p21 through regulation of p50/p50 and IFN-β expression
G. Rackov1, E. Hernández-Jiménez2, M. Álvarez de Mon3, E. López-Collazo2, C. Martínez-A4, D. Balomenos4;
1
National Center for Biotechnology, Madrid, Spain, 2Innate Immunity Group, IdiPAZ, La Paz Hospital, Madrid, Spain, 3Department of Immune System Diseases and Oncology, University Hospital ‘‘Prıncipe
de Asturias’’, Alcala University, Madrid, Spain, 4Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Cientificas (CNB/CSIC), Madrid, Spain.
P.C.11.02
Differential activation mechanisms are induced in macrophages by BCG infection with low bacterial doses
P.C.11.03
Role of CD31 signaling in macrophage polarization and arterial wound healing
P.C.11.04
Regenerative medicine: the role of macrophages during bone tissue regeneration
P.C.11.05
Intrathecal administration of M2-macrophages for treatment of non-acute stroke patients
P.C.11.06
Macrophages - Development, Tissue Specialization and Speficic Functions
P.C.11.07
Suppressive exosome-treated macrophages release hapten-MHC complex-bearing secondary exosomes inhibiting contact sensitivity in mice
P.C.11.08
Macrophages are required for T cell-derived suppressive exosome generation and action
P.C.11.09
The essential role of IL-13 in immunisation against Porphyromonas gingivalis-induced alveolar bone resorption in murine periodontitis model
P.C.11.10
Inflammatory response to saline in the skin of older individuals is driven in part by macrophages
P.C.11.11
Differential regulation of intestinal macrophage function by interleukin-10 and the gut microbiota in the colon versus the small bowel
P.C.11.12
Differential cytokine profiles in in vitro re-programmed monocytes/macrophages: the different types of innate memory
P.C.11.13
M1/M2 macrophages’ balance is altered in multiple sclerosis
P.C.11.14
Neuroimmune crosstalk in uterus among patients suffered with pelvic pain due to adenomyosis
P.C.11.15
Characterization of trefoil factor-3 as a chemokine for monocytes
P.C.11.16
Pseudomonas aeruginosa and macrophage vitamin D receptor expression
P.C.11.17
GM-CSF activated monocytes regulate innate and adaptive immune responses during Intestinal Inflammation
P.C.11.18
TIARA - a methodology for improved discrimination of monocyte and macrophage effector functions
P.C.11.19
A lung-resident Ly6c+ monocyte proliferates to give rise to immunosuppressive lung macrophages
P.C.11.20
Crosstalk between epithelial cells and macrophages in the gut: the role of TNFR2
P.C.11.21
The effects of Paracoccidioides brasiliensis infection on GM-CSF- and M-CSF-induced mouse bone marrow-derived macrophage from resistant and susceptible
mice strains
L. Chavez-Galan1,2, D. Vesin1, D. Mantinvalet1, I. Garcia1;
1
University of Geneva, Geneva, Switzerland, 2National Institute Respiratory Diseases, Mexico City, Mexico.
K. Guedj, M. Clement, J. Khallou-Laschet, G. Fornasa, M. Morvan, A. T. Gaston, F. Andreata, G. Even, M. Le Borgne, B. Escoubet, J. B. Michel, A. Nicoletti, G. Caligiuri;
INSERM U1148, Paris, France.
C. Boiziau1, M. Fenelon1, H. Oliveira1, C. Germain-Genevois2, F. Couillaud2, O. Chassande1, S. Rey1, Z. Ivanovic3, E. Engel4, J. Amedee1, J. Fricain1;
1
INSERM U1026, Bordeaux, France, 2CNRS UMS3428, Bordeaux, France, 3French Blood Institute Aquitaine-Limousin, Bordeaux, France, 4Institute for Bioengineering of Catalonia, Barcelona, Spain.
E. Chernykh, E. Shevela, N. Starostina, S. Morozov, M. Davydova, A. Ostanin;
Institute of Fundamental and Clinical Immunology, Novosibirsk, Russian Federation.
S. Jung, D. Varol, A. Shemer, B. Bernshtein, M. Gross, Y. Wolf, S. Boura-Halfon;
Weizmann Institute of Science, Rehovot, Israel.
K. Nazimek, M. Ptak, W. Ptak, K. Bryniarski;
Department of Immunology Jagiellonian University College of Medicine, Krakow, Poland.
R. S. Lam, N. M. O’Brien-Simpson, J. A. Holden, J. C. Lenzo, G. C. Brammar, Y. Tan, E. C. Reynolds;
Oral Health Cooperative Research Centre, Melbourne Dental School, Bio 21 Institute, The University of Melbourne, Carlton, Victoria, Melbourne, Australia.
E. S. Chambers, N. Patel, M. Vukmanovic-Stejic, A. N. Akbar;
Tuesday
K. Nazimek1, W. Ptak1, P. W. Askenase2, K. Bryniarski1;
1
Department of Immunology Jagiellonian University College of Medicine, Krakow, Poland, 2Section of Allergy and Clinical Immunology, Yale University School of Medicine, New Haven, CT, United States.
E. Mann, P. Andersen, Y. Dong, D. Wang, W. Jiang, J. Foster, D. Peterson, X. Li;
Johns Hopkins University, Baltimore, MD, United States.
P. Italiani1,2, E. Töpfer3, D. Melillo1, D. Boraschi1;
1
National Research Council of Italy, Institute of Protein Biochemistry, Napoli, Italy, 2Institute of Biomedical Technologies, National Research Council of Italy, Milano, Italy, 3AvantiCell Science, Ayr, United
Kingdom.
A. Leuti1,2, A. Gentile1,3, L. Battistini1, D. Centonze1,3, M. Maccarrone1,2, V. Chiurchiù1,2;
1
European Center for Brain Research (CERC)/Santa Lucia Foundation, Rome, Italy, Rome, Italy, 2School of Medicine and Center of Integrated Research, Campus Bio-Medico University of Rome, Rome, Italy,
Rome, Italy, 3Department of Systems Medicine, Multiple Sclerosis Clinical and Research Center, Tor Vergata University and Hospital, Rome, Italy, Rome, Italy.
O. Sulaieva1, M. Orazov2, E. Nosenko3;
1
Zaporozhye State Medical University, Zaporozhye, Ukraine, 2M. Gorky Donetsk National Medical University, Donetsk, Ukraine, 3Odessa National Medical University, Odessa, Ukraine.
M. Nowak1, W. Vogel1, O. Andrén2, S. Perner1;
1
Section of Prostate Cancer Research/Institute of Pathology, University hospital Bonn, Bonn, Germany, 2Institute of Health and Medical Science, University of Örebro, Örebro, Sweden.
W. Nouari, M. Aribi;
Laboratory of Applied Molecular Biology and Immunology. University of Tlemcen, Tlemcen, Algeria.
T. Weinhage1, J. Däbritz2, K. Walscheid1, A. Brockhausen3, T. Wirth1, D. Foell1, G. Varga1;
1
Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster, Münster, Germany, 2Department of Pediatrics, University Hospital Rostock, Rostock, Germany,
3
Department of Dermatology, University Hospital Münster, Münster, Germany.
M. Biburger, F. Nimmerjahn;
Division of Genetics, Biology Department, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
C. Sabatel1, C. Radermecker1, S. Chakarov2, L. Fiévez1, G. Paulissen1, M. Toussaint1, C. Desmet1, F. Ginhoux2, T. Marichal1, F. Bureau1;
1
University of Liege, GIGA-Research, Liege, Belgium, 2Singapore Immunology Network (SIgN), Singapore, Singapore.
M. Kristek1, M. Lynch1, J. deCourcey1, L. E. Collins1, T. Darby2, C. T. Murphy2, A. Quinlan2, C. Hill2, P. Casey2, S. Melgar2, C. E. Loscher1;
1
Dublin City University, Dublin 9, Ireland, 2University College Cork, Cork, Ireland.
C. M. de Souza Silva, A. H. Tavares, D. Paiva Agustinho, M. Sousa Jeronimo, Y. Soares de Lima, L. da Silveira Derengowski, A. Lorenzetti Bocca, I. Silva-Pereira;
University of Brasilia (UnB), Biology Institute, Brasilia-DF, Brazil.
P.C.11.22
Fate mapping reveals prenatal origin of tissue macrophages
P.C.11.23
Fibrodysplasia ossificans progressiva: can PB imunophenotype tell us something?
K. Klapproth1, A. Forsthuber2, S. Schäfer1, K. Busch1, H. R. Rodewald1;
1
Division of Cellular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Department of Dermatology, Medical University Vienna, Vienna, Austria.
G. Del Zotto1, F. Antonini1, C. Ortolani2, S. Cappato1, R. Ravazzolo1,3, R. Bocciardi1,3;
1
Istituto G. Gaslini, Genova, Italy, 2Department of Biomolecular Sciences – University of Urbino, Pesaro-Urbino, Italy, 3Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and
Child Health (DiNOGMI) and CEBR - University of Genova, Genova, Italy.
Chairpersons: Domingo F. Barber; Madrid, Spain / Cecilia Johansson; London, United Kingdom
P.C.12.01
Effects of polyethylenimine-coated SPIONs on macrophage activation and podosome dynamics
P.C.12.02
studies of the human NOD-like receptor family CARD domain containing 5 (NLRC5) protein in macrophages after LPS treatment
P.C.12.03
The Effect of Cigarette Smoke on Macrophage Function in relation to Chronic Obstructive Pulmonary Disease (COPD)
V. Mulens-Arias1, J. M. Rojas1, S. Pérez-Yagüe1, M. P. Morales2, D. F. Barber1;
1
Department of Immunology and Oncology and NanoBiomedicine Initiative, Centro Nacional de Biotecnología (CNB)/CSIC, Madrid, Spain, 2Department of Biomaterials and Bioinspired Materials, Instituto
de Ciencia de Materiales de Madrid, Madrid, Spain.
E. Kovács1, M. M. Budai1, S. Benkő1, A. Jenei2, J. Tőzsér3;
1
University of Debrecen, Department of Physiology, Faculty of Medicine, Debrecen, Hungary, 2University of Debrecen, Department of Biophysics and Cell Biology, Debrecen, Hungary, 3University of
Debrecen, Department of Biochemistry and Molecular Biology, Debrecen, Hungary.
A. A. Sharaf;
69
P.C.12.04
The p50 NF-kB subunit orchestrates tumor-promoting inflammation in colitis-associated colorectal cancer development
P.C.12.05
Homing regulation of distinct macrophage subsets in infection and cancer
P.C.12.06
Aged rat macrophages exhibit impaired response to in vitro stimulation with IL-4
P.C.12.07
Functional aspects of peritoneal macrophages after femoral nerve injury
P.C.12.08
Deciphering the function of folate receptor beta
P.C.12.10
ST2 is a negative regulator of the the immune response against squamous cell carcinoma.
A. Ippolito1, C. Porta1, L. Carraro1, F. Consonni1, G. Celesti2, F. Grizzi2, L. Laghi2, F. Pasqualini2, A. Sica1;
1
University of Eastern Piemonte, Novara, Italy, 2Humanitas Clinical Institute, Rozzano, Italy.
F. Consonni1, M. Totaro1, C. Porta2, A. Sica1;
1
Humanitas Clinical and Research Center, Rozzano, Italy, 2Università Piemonte Orientale, Novara, Italy.
V. Blagojevic1, I. Ćuruvija1, R. Petrović1, I. Vujnović1, M. Dimitrijević1, V. Vujić2, S. Stanojević1, G. Leposavić3;
1
Immunology Research Centre Branislav Janković, Institute of Virology, Vaccines and Sera Torlak, Belgrade, Serbia, 2Department of Chemistry, Faculty of Medicine, University of Belgrade, Belgrade, Serbia,
3
Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
B. Bozic1,2, P. Nedeljkovic3, D. Zmijanjac1,2, B. Pavlovic Draskovic2, M. Vasiljevska2, D. Vucevic2;
1
University of Belgrade, Faculty of biology, Belgrade, Serbia, 2Institute for Medical Research, Military Medical Academy, Belgrade, Serbia, Belgrade, Serbia, 3Department for Plastic and Reconstructive
Surgery, Institute for Orthopaedic Surgery “Banjica”, University of Belgrade, Serbia, Belgrade, Serbia.
C. N. Machacek1, V. Supper1, G. Mitulović1, H. Tichovska2, H. Stockinger1, A. Ohradanova-Repic1;
1
Medical University of Vienna, Vienna, Austria, 2Exbio Praha, Vestec, Czech Republic.
N. Amôr1, C. E. Oliveira1, T. H. Gasparoto1, R. Kaneno2, G. P. Garlet1, J. S. Silva3, G. A. Martins4, C. Hogaboam5, K. A. Cavassani6, A. P. Campanelli1;
Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil, 2Department of Microbiology and Immunology; Institute of Biosciences of Botucatu - São Paulo State
University, Botucatu, Brazil, 3Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil, 4F. Widjaja Foundation Inflammatory
Bowel and Immunobiology Research Institute, Dept. of Biomedical Sciences and Medicine, Cedars–Sinai Medical Center, Los Angeles, CA, United States, 5Division of Pulmonary and Critical Care Medicine,
Department of Medicine, Cedar Sinai Medical Center, Los Angeles, CA, United States, 6Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States.
1
Tuesday
P.C.12.11
LYVE-1, a tumor- associated macrophages marker in mouse and human and its role in cancer biology
P.C.12.12
Innate immune response alterations in elderly subjects after hip fracture
C. S. Dollt, K. Schoenhaar, J. Michel, L. Kloss, A. Krewer, K. Schledzewski, S. Goerdt, A. Schmieder;
Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
B. Sarra1, F. Cabana2, G. Dupuis3, T. Fulop4;
Research Center on Aging, Universite de Sherbrooke, Sherbrooke, QC, Canada, 2Division of Orthopedics, Department of Surgery, Sherbrooke, QC, Canada, 3Department of Biochemistry, Immunology
Programme, Sherbrooke, QC, Canada, 4Research Center on Aging, Université de Sherbrooke, Sherbrooke, QC, Canada.
1
P.C.12.13
Monocyte phenotype and polyfunctionality are associated with elevated soluble inflammatory markers, cytomegalovirus infection and functional and cognitive
decline in the elderly
R. S. de Pablo-Bernal1, M. I. Galvá2, R. Ramos2, J. Cañizares2, S. Ferrando-Martínez3, M. B. Rafii-El-Idrissi1, Y. M. Pacheco1, M. Leal1, E. Ruiz-Mateos1;
1
Biomedicine Institute of Seville, Seville, Spain, 2Heliopolis Nursing Home, Seville, Spain, 3Vaccine Research Center NIAID NIH, Bethesda, MD, United States.
P.C.12.14
Monocyte subsets have different potential for phagocytosis
P.C.12.16
Characterization of the murine pulmonary phagocytic network during Aspergillus fumigatus infection
P.C.12.17
The role of mazEF toxin-antitoxin system in M. tuberculosis to macrophage
P.C.12.18
Antigen targeting to splenic CD169+ macrophages stimulates strong T and B cell responses and is more efficient than antigen targeting to DEC205+ dendritic cells
P.C.12.19
Local inflammatory reactions determine the risk of rebleeding in patients with peptic ulcers
P.C.12.20
Human airway macrophage regulation in health & disease
P.C.12.21
Switch of the red pulp esplenic macrophages activation profile during acute and chronic phases of Plasmodium chabaudi malaria
P.C.12.22
Inhibition of phagocytosis by a novel generated monoclonal antibody COS3A
P.C.12.23
chronic granulomatous disease:genetic studies from one PID center
P.C.12.24
Metabolic activity of monocytes of blood at progressing tuberculosis of the lungs at gender distinctions
Z. Akbulut, F. T. Akdeniz, Ö. Albayrak, G. Terzioğlu, B. Aru, G. Yanıkkaya Demirel;
Yeditepe University, Faculty of Medicine, Immunology Dept, Istanbul, Turkey.
P. Seddigh1, M. Hasenberg1, M. Gunzer1, L. Otto1, T. Bracht2, B. Sitek2;
1
Experimental immunology and imaging, Essen, Germany, 2Medical proteom center, Bochum, Germany.
L. Yuan, a. shen, s. cao;
Medical School of Shihezi University, Shihezi City, China.
H. Veninga, E. Borg, D. van Dinther, M. Revet, H. Kalay, Y. van Kooyk, G. Kraal, J. M. den Haan;
VU University Medical Center, Amsterdam, Netherlands.
O. Sulaieva;
M. Kaur1, D. Singh2, T. Hussell1;
1
Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, United Kingdom, 2University of Manchester, Manchester, United Kingdom.
A. A. Cassado, E. M. Salles, E. P. Amaral, M. N. Menezes, J. M. Alvarez, M. R. D’Império Lima;
P. Khunkaewla1, S. Wansook1, S. Pata2,3, W. Kasinrerk2,3;
1
Biochemistry-Electrochemistry Research Unit, School of Biochemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand, 2Division of Clinical Immunology,
Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand, 3Medical Biotechnology Unit, National Center for Genetic Engineering and
Biotechnology, National Science and Technology Development Agency at the Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
S. Nepesov1, F. D. Aygun1, M. Y. Koker2, B. Saraymen2, H. Cokugras1, Y. Camcioglu1;
1
Pediatric Allergy And Immunology, Cerrahpasa Medical School, Istanbul, Turkey, 2Hematology-Immunology, University Of Erciyes, Kayseri, Turkey.
Chairpersons: Silke Appel; Bergen, Norway / Georgina Clark; Sydney, Australia (tbc)
70
P.C.13.01
Assessment of cytokine pattern in intact and generated dendritic cells in rheumatoid arthritis patients
P.C.13.02
Interplay between the c-kit/Stem Cell Factor axis and the TLR ligands CpG and PolyI:C in mouse Dendritic Cells
P.C.13.03
Cytokine production by T cells activated by dendritic cells generated in the environment of immunosuppressive agents
P.C.13.05
Unravelling the key functions of conserved genes in XCR1+ dendritic cells by systems immunology
P.C.13.07
Effects of genetically modified Lactobacillus casei BL23 on human monocyte-derived dendritic cell functions
S. Falaleeva, V. Kurilin, N. Shkaruba, O. Chumasova, A. Sizikov, S. Sennikov;
Federal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”, Novosibirsk, Russian Federation.
A. B. Barroeta Seijas1, S. Simonetti1, D. Runci2, S. Vitale1,3, A. C. Quinci1, A. Soriani1, I. Filippi4, A. Naldini4, A. Santoni1, F. Di Rosa5;
1
Department of Molecular Medicine, University of Rome “Sapienza”, Rome, Italy, 2Istituto Pasteur – Fondazione Cenci Bolognetti, Rome, Italy, 3Istituto Superiore di Sanità, Rome, Italy, 4Department of
Molecular and Developmental Medicine, University of Siena, Siena, Italy, 5Institute of Biology and Molecular Pathology (IBPM), National Research Council (CNR), Rome, Italy.
M. Machcińska1, M. Rząca1, A. Cieślikowska1, Z. Kotkowska1, A. Łaski1, G. Korczak-Kowalska1,2;
1
Department of Immunology, Faculty of Biology, University of Warsaw, Warsaw, Poland, 2Transplantation Institute, Medical University of Warsaw, Warsaw, Poland.
C. Arnold-Schrauf, S. Balan, S. Ghilas, F. Imperatore, R. Chelbi, K. Crozat, M. Dalod;
Centre d’Immunology de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.
M. Tóth1, P. Gogolák1, K. Regulski2, M. Chapot-Chartier2, É. Rajnavölgyi1;
1
University of Debrecen, Debrecen, Hungary, 2Institut National de la Recherche Agronomique, Jouy-en-Josas, France.
P.C.13.08
Skin inflammation-induced uptake of mast cell granules by dendritic cells and active shuttling to draining lymph nodes
P.C.13.10
Regulating immunogenicity and tolerogenicity of BMDCs through modification of cell surface glycosylation
P.C.13.11
Role of skin migratory antigen-presenting cells in T follicular helper cell polarization after intradermal vaccination
P.C.13.12
Effect of protein aggregates from therapeutic proteins on dendritic cells maturation: Examples of Rituximab and Somatropin
P.C.13.13
Autophagic protein Atg5 is required for MHC class II presentation of tumor antigens by dendritic cells
P.C.13.14
Regulation of necroptosis as a viral immune antagonist mechanism
P.C.13.15
Trans-activation of innate immune cells by Hepatitis C subgenomic replicon cells
P.C.13.16
The Anti-Inflammatory Effects of Microparticles in Human Plasmacytoid Dendritic Cells Involves Liver X Receptor Activation
P.C.13.17
Vδ2+ γδ T cells contain the cytolytic effector molecule granulysin, and can be activated and induced to release this molecule in response to BCG treatment
P.C.13.18
The immune-modulatory role of Apolipoprotein E
J. Dudeck1, A. Karutz1, A. Hoppe1, S. Speier2,3,4, A. Dudeck1;
1
University of Technology Dresden, Medical Faculty, Institute for Immunology, Dresden, Germany, 2Paul Langerhans Institute Dresden (PLID) of Helmholtz Centre Munich at the University Clinic Carl Gustav
Carus of the Technische Universität Dresden, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, 3German Centre for Diabetes Research (DZD),
Dresden, Austria, 4DFG-Center for Regenerative Therapies Dresden (CRTD), Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
K. Lynch1, H. Annuk2, J. Gerlach2, L. O’Flynn1, A. Ryan1, P. Lohan1, M. Kilcoyne2, L. Joshi2, T. Ritter1;
1
Regenerative Medicine Institute (REMEDI), College of Medicine, Nursing & Health Sciences, National University of Ireland, Galway., Galway, Ireland, 2Glycoscience Group, NCBES National Centre for
Biomedical Engineering Science, National University of Ireland, Galway., Galway, Ireland.
C. Levin1,2, C. Nuttens1,2, O. Bonduelle1,2, N. Fazilleau3, B. Verrier4, B. Combadiere1,2;
1
INSERM U1135 Cimi-Paris, Paris, France, 2Sorbonne Universités, UPMC Univ Paris 06, UMR S CR7 Cimi-Paris, Paris, France, 3Centre de physiopathologie de Toulouse-Purpan, UMR 1043, CHU Purpan,
Toulouse, France, 4Institut de Biologie et Chimie des Protéines, Centre National de la Recherche Scientifique, Université Claude Bernard de Lyon, Lyon, France.
Y. Gallais1, N. Szely1, F. Legrand2, A. Leroy3, M. Pallardy1, I. Turbica1;
1
INSERM UMR996, Châtenay Malabry, France, 2CNRS UMR 8612, Châtenay Malabry, France, 3CNRS, UMR 8525, Institut Pasteur de Lille, Lille, France.
B. M. Hartmann, R. A. Albrecht, N. Marjanovic, S. C. Sealfon;
Icahn School of Medicine at Mount Sinai, New York, NY, United States.
V. Kloess, O. Gruenvogel, T. Eigenbrod, V. Lohmann, A. H. Dalpke;
University Heidelberg, Dept. of Infectious Diseases, Heidelberg, Germany.
A. Ceroi1,2, F. Angelot-Delettre1, C. Marotel1, T. Gauthier1, A. Asgarova1, S. Biichlé1, A. Duperrier1, S. Perruche1,2, L. Lagrost3,2, D. Masson3,2, P. Saas1,2;
1
UMR 1098 INSERM, Université de Bourgogne Franche-Comté, EFS Bourgogne Franche-Comté, Besançon, France, 2LabEx LipSTIC, Besançon/Dijon, France, 3INSERM U866, Faculté de Médecine, Université
de Bourgogne Franche-Comté, Dijon, France.
Tuesday
D. Oh, H. Lee;
KAIST, Daejeon, Korea, Republic of.
E. L. Sparrow, D. W. Fowler, A. G. Dalgleish, M. D. Bodman-Smith;
St.Georges, University of London, London, United Kingdom.
E. Kaminska, T. Alaguthurai, J. P. Copier, A. G. Dalgleish, M. D. Bodman-Smith;
Institute of Infection and Immunity, St. George’s University of London, London, United Kingdom.
Chairpersons: Esther Wilk; Braunschweig, Germany / Albert Duschl; Salzburg, Austria
P.C.14.01
STIM1 assumes a regulatory role in LPS-induced sepsis
G. Sogkas1, E. Rau1, T. Vögtle2, D. Stegner2, B. Nieswandt2, R. Schmidt1, J. Gessner1;
Hannover Medical University, Clinical Immunology and Rheumatology, Hannover, Germany, 2University Hospital and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University
of Würzburg, Chairpersons: of Experimental Biomedicine, Würzburg, Germany.
1
P.C.14.02
Cooperation of TLRs and cytosolic innate immune sensors
P.C.14.03
TLR4 /TREM-1 co-expression in CD14+ monocytes as a diagnostic and predictive tool in sepsis
P.C.14.04
TNIP1 negatively regulates the Propionibacterium acnes-induced innate immune and inflammatory signaling pathways in human immortalized keratinocytes
P.C.14.05
Ubiquitylation of Unc93b1 controls Toll-like receptor sorting and responses to self-ligands
P.C.14.06
Lysosomal trafficking regulator Lyst links membrane trafficking to Toll-like receptor-mediated inflammatory responses
P.C.14.07
Mycobacterium leprae signalling through Toll-like Receptor-4, and the influence of Bacillus Calmette-Guerin vaccination
P.C.14.08
Toll-like receptor 7 and 9 in the pathogenesis of inflammatory autoimmune arthritis
P.C.14.09
A bioinformatics-based approach to identify new candidate pathogen resistance genes in corals
P.C.14.10
Immunomudulatory effects of extracellular vesicles
P.C.14.11
Mannose receptor negatively modulates the TLR4-AhR-IDO axis in dendritic cells with implications in allergic responses
P.C.14.12
Targeting of DEC205 and DCIR on human dendritic cells elicits differential immune responses
P.C.14.13
In vitro assessment of immunomodulatory effects of recombinantly produced BanLec isoform on murine peritoneal macrophages
P.C.14.14
Cell-based reporter assay using innate and acquired fusion immune receptors for detecting beta-glucans
G. Tincer König, I. Gursel;
I. Gkougkourelas, A. Sarantopoulos, K. Tselios, P. Boura;
Hippokration General Hospital, Thessaloniki, Greece.
L. Erdei1, G. Tax1, B. S. Bolla1, E. Urbán2, L. Kemény1,3, K. Szabó3;
1
Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary, 2Institute of Clinical Microbiology, University of Szeged, Hungary, Szeged, Hungary, 3MTA-SZTE Dermatological
Research Group, Szeged, Hungary, Szeged, Hungary.
O. Majer, B. Liu, G. Barton;
University of California, Berkeley, Berkeley, CA, United States.
A. Westphal, W. Cheng, J. Yu, K. Lee, N. Föger;
Institute for Clinical Chemistry, Div. Inflammation Research, Hannover Medical School, Hannover, Germany.
A. Polycarpou, M. J. Holland, S. L. Walker, S. Willcocks, D. N. Lockwood;
London School of Hygiene and Tropical Medicine, London, United Kingdom.
A. Fischer, S. Herman, C. Böhm, V. Saferding, E. Goncalves-Alves, G. Steiner;
Department of Rheumatology, Medical University of Vienna, Vienna, Austria.
K. E. Garrison;
Saint Mary’s College of California, Moraga, CA, United States.
B. Yildiz;
Bilkent University, Ankara, Turkey.
F. Salazar, L. Hall, F. Shakib, A. Ghaemmaghami;
G. Heidkamp1, J. Lühr1, N. Eissing1, L. Heger1, A. Baranska1, C. Lehmann1, I. Böhme1, L. Bozzacco2, C. Trumpfheller2, E. Kremmer3, H. Zebroski4, G. Schuler5, M. C. Nussenzweig6, F. Nimmerjahn7, D. Dudziak1;
1
Department of Dermatology, Laboratory of Dendritic Cell biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitiy Hospital Erlangen, Erlangen, Germany, 2Laboratory of Cellular Physiology
and Immunology, and Chris Browne Center of Immunology and Immune Disease, The Rockefeller University, New York, NY, United States, 3Institute of Molecular Immunology, Helmholtz-Center Munich,
München, Germany, 4Proteomics Resource Center, The Rockefeller University, New York, NY, United States, 5Department of Dermatology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitiy
Hospital Erlangen, Erlangen, Germany, 6Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, United States, 7Department of Biology, Chairpersons: of Genetics, FriedrichAlexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
E. Marinkovic1, I. Lukic1, A. Filipovic1, O. Krnjaja1, D. Kosanovic1, M. Gavrović-Jankulović2, M. Stojanovic1;
1
Institute of Virology, Vaccines and Sera-Torlak, Belgrade, Serbia, 2Department of Biochemistry, Faculty of Chemistry, University of Belgrade, Belgrade, Serbia.
Y. Adachi, K. Ishibashi, D. Yamanaka, N. Ohno;
Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
71
P.C.14.15
Hypoallergenic Bet v 1.0101-Mannan neoglycoconjugates are highly immunogenic when applied via laserporated skin
P.C.14.16
Anti-inflammatory effect of Pectin is Toll-like receptor dependent
P.C.14.17
Optimization of the immunogenicity of VLPs-based vaccines using TLR ligands.
P.C.14.18
Epigenetic modifications regulate Toll-like receptor 3 expression in intestinal epithelial and monocytic cells
P.C.14.19
Involvement of infectious agents on trafficking of effector T cells is mediated by a polymorphic site of TLR2 and CD44 isoforms expression
Y. J. Machado1, M. Mayr1, T. Thalhamer1, M. Schmid2, U. Ritter2, S. Gordon3, C. Lehr3, S. Scheiblhofer1, J. Thalhamer1, R. Weiss1;
1
University of Salzburg, Department of Molecular Biology, Salzburg, Austria, 2University of Regensburg, Department of Immunology, Regensburg, Germany, 3Helmholtz-Institute for Pharmaceutical
Research Saarland, Saarbrücken, Germany.
N. M. Sahasrabudhe;
University Medical Center Groningen, Groningen, Netherlands.
A. Cruz Gomes, A. El-Turabi, A. Reyes Sandoval, M. F. Bachmann;
University of Oxford, Oxford, United Kingdom.
C. Hennessy, D. P. Mckernan;
NUI Galway, Galway, Ireland.
G. Di Sante1,2, M. Valentini1, G. Migliara1, A. Piermattei1, B. Tolusso2, G. Constantin3, E. Stigliano4, M. Geloso4, S. Hayrabedyan5, G. Delogu6, F. Ria1;
Institute of General Pathology - Università Cattolica del Sacro Cuore, Rome, Italy, 2Institute of Rheumatology - Università Cattolica del Sacro Cuore, Rome, Italy, 3Institute of General Pathology - Università
di Verona, Verona, Italy, 4Institute of Anatomy - Università Cattolica del Sacro Cuore, Rome, Italy, 5Institute of Biology and Immunology of Reproduction at Bulgarian Academy of Sciences, Sofia, Bulgaria,
6
Institute of Microbiology - Università Cattolica del Sacro Cuore, Rome, Italy.
1
P.C.14.20
TLR8 and HLA-G up-regulation in placental tissue from infected-mother compare to uninfected control
Tuesday
E. C. Cardoso, M. N. Sato, E. F. Bevilacqua;
USP, Sao Paulo, Brazil.
Chairpersons: Danka Grcevic; Zagreb, Croatia / Rudolf Oehler; Wien, Austria
72
P.C.15.01
12/15-lipoxygenase counteracts the activity of NLRP3 inflammasome in monocytes
P.C.15.02
Increased TNFα levels in the intestinal tissue, but not in the brain, following severe acute pancreatitis
P.C.15.03
Down-regulation of atypical chemokine receptor ACKR2 expression by hematopoietic progenitors promotes myeloid cell mobilization and differentiation
P.C.15.04
Caffeine modulates cytokine production by M-MFs: study of the NLRP3 inflammasome-mediated IL-1β cytokine
P.C.15.05
Evaluation of cytokine profile in Ipilimumab treated Melanoma patients
P.C.15.06
Cytokines correlates with outcomes in trauma hemorrhagic shock patients
P.C.15.07
The involvement of H3 histamine receptors in the synthesis of cytokines and chemokines by mononuclear and dendritic cells
P.C.15.08
Anti-IL-20 monoclonal antibody suppresses prostate cancer growth and bone osteolysis in murine models
P.C.15.09
Interleukin-4 (IL-4) gene polymorphism is associated with febrile seizure in Iranian children
P.C.15.10
Strain differences in sterile inflammation and immune suppression induced by acute cadmium administration in rats depend on the affected activity and tissue
P.C.15.11
Molecular dissection of signaling pathways initiated at IL-33/ST2 axis in human cord blood derived mast cells
P.C.15.12
Investigating a novel function of a novel cytokine: the role of interleukin-34 in anti-viral responses
P.C.15.13
IL-12 signals directly to the intestinal epithelium via IL-12Rβ2
P.C.15.14
Virus-induced type I interferon deteriorates control of systemic Pseudomonas aeruginosa infection
P.C.15.15
A critical neutrophil/gamma-delta T17 cell axis in innate host response to acute Streptococcus pneumoniae infection
P.C.15.16
The role of IL-33/ST2 axis in alteration of antioxidative parameters in acute inflammation
P.C.15.17
Processing of apoptotic cell remnants
Y. Kusche, J. Roth, K. Barczyk-Kahlert;
Institute of Immunology, Münster, Germany.
M. Y. Hamasaki;
University of Sao Paulo, Sao Paulo, Brazil.
O. Bonavita1,2, N. Caronni1,2, B. Savino1,2, M. Massara1,2, L. Crisafulli1,3, F. Ficara1,3, A. Mantovani1,4, M. Locati1,2, R. Bonecchi1,4;
1
Humanitas Clinical and Research Center, Rozzano, Italy, 2Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Rozzano, Italy, 3Istituto di Ricerca Genetica e
Biomedica, Consiglio Nazionale delle Ricerche, Milan, Italy, 4Humanitas University, Rozzano, Italy.
B. M. Marietta1, B. Ágnes1, T. József2, B. Szilvia1;
1
University of Debrecen, Department of Physiology, Debrecen, Hungary, 2University of Debrecen, Department of Biochemistry and Molecular Biology, Debrecen, Hungary.
E. Palella1, R. Tallerico1, C. M. Cristiani1, M. Capone2, G. Madonna2, C. Garofalo1, E. Staaf3, D. Mallardo2, E. Simeone2, A. M. Grimaldi2, G. Ciliberto1,2, M. Greco4, E. Gulletta4, F. Colucci5, K. Karre3, P. A.
Ascierto2, E. Carbone1,3;
1
Tumorimmunology and Immunopathology Laboratory, Department of Experimental and Clinic Medicine, University “Magna Graecia” of Catanzaro, Catanzaro, Italy, 2Melanoma Cancer Immunotherapy
and Innovative Therapy Unit, Tumor National Institute, Napoli, Italy, 3Department of Microbiology Cell and Tumorbiology (MTC), Karolinska Institutet, Stockholm, Sweden, 4Department of Health Sciences,
Magna Græcia University of Catanzaro, Catanzaro, Italy, 5Department of Obstetrics and Gynaecology, University of Cambridge Clinical School, Cambridge, United Kingdom.
M. Kumar1, D. Rao2, V. Kamal3, S. Bhoi1;
1
Department of Emergency Medicine, JPN Apex Trauma Center, AIIMS, New Delhi, New Delhi, India, 2Department of Biochemistry, AIIMS, New Delhi, New Delhi, India, 3AIIMS, New Delhi, New Delhi, India.
V. Evstratova1, N. Rieger1, A. Tutelyan2, R. Khanferyan1;
1
Scientific Research Institute of Nutrition, Moscow, Russian Federation, 2Federal Scientific Clinical Centre of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation.
Y. Hsu1,2, M. Chang2;
1
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 2Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung
University, Tainan, Taiwan.
S. Zoghi1, A. Zare-shahabadi2, S. Soltani1, M. Ashrafi3, A. Shahrokhi4,5, N. Rezaei1,2,3;
1
Molecular Immunology Research Center; and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, tehran, Iran, Islamic Republic of, 2Research Center for
Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 3Pediatrics Center of Excellence, Children’s Medical
Center, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 4Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, tehran, Iran, Islamic
Republic of, 5Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran, Islamic Republic of.
J. Demenesku1, I. Mirkov1, M. Ninkov1, A. Popov Aleksandrov1, L. Zolotarevski2, V. Subota3, D. Mileusnic1, D. Kataranovski1,4, M. Kataranovski1,5;
1
Institute for Biological Research “Sinisa Stankovic”, Belgrade, Serbia, 2Institute of Pathology, Military Medical Academy, Belgrade, Serbia, 3Institute for Biochemistry, Military Medical Academy, Belgrade,
Serbia, 4Institute of Zoology, Faculty of Biology, University of Belgrade, Belgrade, Serbia, 5Institute of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
P. Pushparaj, K. Narasimhan, M. Rasool, M. I. Naseer, K. Gauthaman;
Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
M. Sims, S. Spence, M. Greene, D. McAuley, A. Kissenpfennig;
N. R. Gicheva, K. Ivory, C. Deen, A. Man, C. Nicoletti;
Institute of Food Research, Norwich, United Kingdom.
K. Merches1, V. Khairnar1, N. Shaabani1, N. Honke1, F. Lang2, E. Gulbins3, B. Tümmler4, K. S. Lang1;
1
Institute of Immunology, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany, 2Department of Physiology, Faculty of Medicine, University of Tübingen, Tübingen, Germany, 3Department of
Molecular Biology, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany, 4Department of Pediatrics, Faculty of Medicine, University of Hannover, Hannover, Germany.
M. Hassane;
Pasteur institute of Lille, Lille, France.
M. Stankovic1, S. De Luka1, N. Petronijevic2, M. Velimirovic2, T. Stojkovic2, N. Puskas3, I. Zaletel3, A. Trbovich1;
1
University of Belgrade Faculty of Medicine, Department of Pathophysiology, Belgrade, Serbia, 2University of Belgrade Faculty of Medicine, Institute of Clinical and Medical Biochemistry, Belgrade, Serbia,
3
University of Belgrade Faculty of Medicine, Institute of Histology, Belgrade, Serbia.
Y. Y. Liang, D. Rainprecht, E. Eichmayr, B. Messner, R. Oehler;
P.C.15.18
Cytokine-induced neutrophil chemokine responses following burn and sepsis
P.C.15.19
Double-stranded RNA induced cytokines in ex vivo cultivated peripheral blood mononuclear cells
P.C.15.20
The Effect of Exhaustion Training on HSP 70 and Glucose
P.C.15.21
H3/H4 histamine receptor antagonists and their impact on IgE and IgE-regulatory cytokine’s synthesis
N. Fazal, E. Cheptene, E. Arabian, A. Royan;
Chicago State University, Chicago, IL, United States.
K. Vaivode1, R. Petrovska1, I. Marksa2, R. Brūvere1, S. Magone1, D. Pjanova1;
1
Latvian Biomedical Research and Study Center, Riga, Latvia, 2University of Latvia Experimental and Clinical Research Center, Riga, Latvia.
1
Varamin Pishva Branch, Islamic Azad University, Varamin, pishva, Iran, Islamic Republic of, 2Financial Managemenmt, Dustan Equipent, Tehran, Iran, Islamic Republic of.
N. Riger, V. Evstratova, E. Savtchenko, R. Khanferyan;
Chairpersons: Elke Scandella; St.Gallen, Switzerland / Hannes Stockinger; Vienna, Austria
P.C.16.01
Multiplexing NFκB translocation with immunophenotyping and screening of NFκB inhibitors using imaging flow cytometry
P.C.16.02
Analyses of intracellular molecule expression in gated effectors NK cells by flow cytometry in comparison to rate of death target, K-562 cells
P.C.16.03
Molecular determinants of NLRC5-mediated MHC class I transcriptional regulation in human cells
P.C.16.04
The influence of peritoneal macrophages from animals with Lewis lung carcinoma on endothelial cell cycle
P.C.16.05
Non-canonical and cell type-specific functions of Tyk2 in the defence against Listeria monocytogenes
P.C.16.06
Mechanisms of immune modulation by vaccinia virus protein C16
V. Jurisic1, K. Mirjacic-Martinovic2, T. Srdic-Rajic2, A. Radovanovic3, N. Tisma3, G. Konjevic3;
1
University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia, 2Institute of Oncology and Radiology, Belgrade, Belgrade, Serbia, 3Institute of Oncology and Radiology, Belgrade, Serbia.
A. Neerincx1, F. Hezel2, K. Jakobshagen3, H. Büning4, O. Utermöhlen3, V. Steimle5, T. A. Kufer2;
1
Department of Pathology, University of Cambridge, Cambridge, United Kingdom, 2Dep. of Immunology, University Hohenheim, Stuttgart, Germany, 3Institute for Medical Microbiology, Immunology and
Hygiene, University of Cologne, Cologne, Germany, 4Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany, 5Département de Biologie, Université de Sherbrooke, Sherbrooke, QC,
Canada.
Tuesday
H. R. Pugsley1, K. Eberhart2, K. Tyagarajan1, K. Gillis3, S. Friend1, P. Morrissey1;
1
Merck Millipore, Seattle, WA, United States, 2Merck Millipore, Darmstadt, Germany, 3Merck Millipore, Hayward, CA, United States.
T. Nikolaienko1, D. Shelest1, I. Gutich1, L. Garmanchuk1, O. Khudiakova2;
1
Educational and Scientific Centre «Institute of Biology» of Taras Shevchenko National University of, Kyiv, Ukraine, 2Luhansk Taras Shevchenko National University, Luhansk, Ukraine.
N. Boović1, C. Lassnig1,2, S. Stockinger1, K. Meissl1, B. Strobl1, M. Müller1,2;
1
Institute for Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria, 2Biomodels Austria, University of Veterinary Medicine, Vienna, Austria.
S. R. Scutts1, N. E. Peters1, C. Leonarz2, M. Mazzon1, R. P. Sumner1, D. L. Veyer1, G. L. Smith1;
University of Cambridge, Cambridge, United Kingdom, 2University of Oxford, Oxford, United Kingdom.
1
P.C.16.07
Measuring autophagic flux by assessing LC3, p62 and LAMP1 co-localization in Jurkat cells using imaging flow cytometry
P.C.16.08
Microparticles produced by flavivirus-infected endothelium are antiviral and effectively immunise against flavivirus infection
P.C.16.09
Response to interferons and antibacterial innate immunity in absence of tyrosine-phosphorylated STAT1
P.C.16.10
Calpain activity is essential for ATP-driven unconventional protein secretion and inflammasome activation in human macrophages
P.C.16.11
SOCS1 up-regulates Nrf2-mediated antioxidant factors to inhibit inflammatory cytokine production induced by TLR4 signal
P.C.16.12
Mechanism of SOCS3 action on the M1 and M2 type macrophage differentiation
P.C.16.13
Transmembrane adaptor protein SCIMP and its role in immune cell signaling
P.C.16.14
Role of IP3R3 in CD14-NFAT pathway activation
P.C.16.15
A signal transduction map of inflammatory macrophages during bacterial lung infections: Topologically central proteins, pathogen-affected subnetworks and
drug-regulated proteins unravel potential mechanism of immunomodulation
H. R. Pugsley1, K. Eberhart2, S. Seth2, S. L. Friend1, P. Morrissey1;
1
Merck Millipore, Seattle, WA, United States, 2Merck Millipore, Darmstadt, Germany.
Z. L. Ling1, V. Combes1,2, G. E. Grau1, N. J. King1;
1
Discipline of Pathology, University of Sydney, Sydney, Australia, 2University of Technology Sydney, Sydney, Australia.
A. Majoros1, H. Cheon2, C. Vogl3, P. Shukla3, G. R. Stark2, V. Sexl4, R. Schreiber5, C. Schindler6, M. Müller3, T. Decker1;
1
Max F. Perutz Laboratories, University of Vienna, Veinna, Austria, 2Department of Molecular Genetics and Proteomics Core, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States,
3
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Veinna, Austria, 4Institute of Pharmacology and Toxicology, Department for Biomedical Sciences, University of
Veterinary Medicine Vienna, Veinna, Austria, 5Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, United States, 6Departments of Microbiology &
Immunology and Medicine, Columbia University, New York, NY, United States.
E. Välimäki1,2, W. Cypryk3, J. Virkanen4, K. Nurmi5, T. A. Nyman3, S. Matikainen2;
1
University of Helsinki, Helsinki, Finland, 2Finnish Institute of Occupational Health, Helsinki, Finland, 3Institute of Biotechnology, University of Helsinki, Helsinki, Finland, 4Department of Geosciences and
Geography, University of Helsinki, Helsinki, Finland, 5Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland.
C. Lee, G. Kim, B. Jeong, H. Yoon;
Sungkyunkwan University, Suwon, Korea, Republic of.
C. Lee, H. Yoon, G. Kim;
Sungkyunkwan University, Suwon, Korea, Republic of.
J. Kralova, M. Fabisik, I. Danyi, T. Brdicka;
Institute of Molecular Genetics of the ASCR, Prague, Czech Republic.
L. Marongiu1, M. Di Gioia2, V. Poli1, I. Zanoni2,1, F. Granucci1,3;
1
University of Milano Bicocca, Milano, Italy, 2Harvard Medical School, Boston, MA, United States, 3Humanitas Clinical and Research Center, Rozzano (MI), Italy.
P. Wentker1, M. Eberhardt1, M. Cantone1, N. Tomar1, U. Schmitz2, S. Gupta2, O. Wolkenhauer2, J. Vera1;
1
University Hospital Erlangen, Erlangen, Germany, 2University of Rostock, Rostock, Germany.
Chairpersons: Sukanya Raghavan; Gothenburg, Sweden / Susanne Vrtala; Vienna, Austria
P.D.11.01
Age-related differences of humoral and cellular immune responses to primary vaccination against Japanese Encephalitis
A. Wagner1, E. Garner-Spitzer1, J. Jasinska1, M. Prelog2, K. Stiasny3, F. Heinz3, H. Kollaritsch1, U. Wiedermann1;
Institute of Specific Prophylaxis and Tropical Medicine, Vienna, Austria, 2Department of Pediatrics, Wuerzburg, Germany, 3Department of Virology, Vienna, Austria.
1
P.D.11.02
Isolation, Preparation and Evaluation of The Immunogenicity Effectiveness of A Novel Inactivated Rotavirus Vaccine Strain: ZTR-68, Rotavirus A Genotype G1P[8]
P.D.11.03
Humoral and cellular responsiveness to routine vaccines in allergic individuals with and without specific immunotherapy
J. Wu, G. Zhang, S. Yi, Y. Zhou, N. Yin, Y. Xie, H. Li, M. Sun;
Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, China.
E. Garner-Spitzer1, M. Hofer1, C. Seidl-Friedrich1, R. Jarisch2, T. Kinaciyan3, M. Kundi4, U. Wiedermann1;
Institute for Specific Prophylaxis &Tropical Medicine, Medical University of Vienna (MUV), Vienna, Austria, 2Allergiezentrum Floridsdorf, Vienna, Austria, 3Department of Dermatology, DIAID, MUV, Vienna,
Austria, 4Institute for Public Health, MUV, Vienna, Austria.
1
73
P.D.11.04
Schistosoma mansoni Venom Allergen-Like (SmVAL) protein co-administration in a vaccine assay against schistosomiasis
P.D.11.05
Role of social mobilization in polio eradication program in marginalised communities of Aligarh, India
R. S. Fernandes1, T. C. Barbosa1, H. K. Roffato1, L. P. Farias2, L. C. Leite1;
1
Instituto Butantan, Sao Paulo, Brazil, 2Fundação Oswaldo Cruz, Salvador, Brazil.
M. A. Ansari, Z. Khan;
Community Medicine, J.N.Medical College, Aligarh, India.
P.D.11.06 Analysis of the immune response elicited by the PspA-PlD1 protein chimera in a mouse model of pneumococcal pneumonia
D. Rodriguez1, T. Santos2, C. Goulart1, T. R. Converso1, J. Pereira3, L. Leite1, M. Darrieux3;
1
Instituto Butantan, São Paulo, Brazil, 2Universidade de São Paulo, São Paulo, Brazil, 3Universidade São Francisco, Bragança Paulista, Brazil.
P.D.11.07
Evaluation of recombinant BCG overexpressing the antigen heparin-binding hemmagglutinin adhesin in a murine model of progressive pulmonary tuberculosis
K. García-Rodríguez1, D. Mata-Espinosa1, J. Barrios-Payan1, B. Marquina-Castillo1, M. Flores2, R. Hernández-Pando1;
1
National Institute of Medical Sciences and Nutrition, Mexico, Mexico, 2Center of Technology and Research, Jalisco, Mexico.
P.D.11.08 Human XCL1 targeted vaccines induce strong and protective antibody responses in mice
A. Gudjonsson, E. Fossum, B. Bogen;
K.G. Jebsen Center for Influenza Vaccine Research, Institute of Immunology, University of Oslo and Oslo University Hospital, Oslo, Norway.
P.D.11.09 Induction of massive antigen-specific CD8+ T cell cytotoxicity by targeting of antigen into XCR1+ DC combined with potent amplification regimes
Y. Yang, E. Hartung, A. Jäkel, N. Reeg, S. Gurka, H. W. Mages, R. A. Kroczek;
P.D.11.10
Diphtheria toxoid (Diph)-, tetanus toxoid (Tet)-, and Pneumococcus (PCP)-, Haemophilus influenzae type b (Hib) specific IgG levels in healthy subjects and in
patients with immunodeficiency in hungary
Tuesday
Z. Szabó1, A. Kulcsár2, I. Csürke3, E. Galbicsek4, N. Hartvig1, Á. Kalmár5, É. Karászi2, G. Kriván2, B. Mosdósi6, É. Rimanóczy4, J. Simon1, M. Szolnoky7, L. Tímár2,4, K. Miklós1;
1
HDF MC Military Hospital, Budapest, Hungary, 2United St Istvan and St Laszlo Hospital, Budapest, Hungary, 3Jósa András Teaching Hospital, Nyíregyháza, Hungary, 4Heim Pál Children’s Hospital,
Budapest, Hungary, 5St John’s Hospital, Budapest, Hungary, 6University of Pécs, Clinical Center, Department of Pediatrics, Pécs, Hungary, 7St John’s Hospital, Budapest, Budapest, Hungary.
P.D.11.11
A cationic micelle carrier improves vaccination outcomes against unmodified whole protein antigen
P.D.11.12
Recombinant adeno-vaccine expressing enterovirus 71-like particles against hand, foot, and mouth disease
P.D.11.13
Design of a vaccine made of a synthetic gene composed by T cell epitopes of putative proteins of Rhipicephalus microplus ticks
P.D.11.14
Immunogenicity and protective efficacy of a novel vaccine candidate against tuberculosis based on recombinant BCG
P.D.11.15
Photochemical internalization as novel vaccination technology to enhance antigen-specific CD8+ T cell responses
P.D.11.16
Intradermal injection of antibodies against lectin receptors targets defined subsets of dendritic cells in human skin
C. E. Brubaker1, V. Panagiotou1, J. A. Hubbell1,2;
1
Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland, 2University of Chicago, Chicago, IL, United States.
Y. Tsou1,2, Y. Lin1, H. Shao1,2, S. Yu1, S. Wu3, H. Lin1, C. Liu1, C. Huang1, P. Chong1,4, Y. Chow1,4;
1
Institute of Infectious Disease and Vaccinology, NHRI, Zhunan, Miaoli County, Taiwan, 2Graduate Program of Biotechnology in Medicine, Institute of Molecular and Cellular Biology, NTHU, Hsinchu,
Taiwan, 3Institute of Oral Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan, 4Graduate Institute of Immunology, China Medical University, Taichung, Taiwan.
A. Fisch, I. K. Santos, S. R. Maruyama, E. Anatriello, B. R. Ferreira;
Universidade de São Paulo, Ribeirão Preto, Brazil.
C. C. Santos1,2, I. P. Nascimento1, D. Rodriguez1, L. C. Leite1;
1
Instituto Butantan, São Paulo, Brazil, 2Programa de pós-graduação interunidades em biotecnologia – USP-IB-IPT, São Paulo, Brazil.
M. Haug1,2, H. Ibrahim1,2, G. Brede2, T. H. Flo1,2, A. Høgset3, Ø. Halaas2;
1
Centre of Molecular Inflammation Research (CEMIR), NTNU, Trondheim, Norway, 2Department of Cancer Research and Molecular Medicine (IKM), Trondheim, Norway, 3PCI Biotech AS, Lysaker, Norway.
S. Schaffenrath1,2, C. H. Tripp1, D. Reider1, B. Del Frari1, G. Djedovic1, S. Ebner1, N. Romani1, P. Stoitzner1;
Innsbruck Medical University, Innsbruck, Austria, 2Oncotyrol – Center for Personalized Cancer Medicine, Innsbruck, Austria.
1
P.D.11.17
The role of immune cells and cytokines in vaccine-induced protection against gastric Helicobacter pylori infection
L. S. Ottsjö1, R. Malefyt2, A. K. Walduck3, S. Raghavan1;
1
Microbiology and Immunology, Gothenburg, Sweden, 2Department of Immunology, Merck Pharmaceuticals, CA, United States, 3RMIT University, Melbourne, Australia.
P.D.11.18 Mucosal delivery of novel secreted proteins that protect against infection by the parasitic nematode Trichinella spiralis
A. Taccogna1, T. Lamb2, M. Selkirk3, D. Guiliano1;
1
Univerisity of East London, London, United Kingdom, 2Emory University, Atlanta, GA, United States, 3Imperial College London, London, United Kingdom.
P.D.11.19
Polybacterial sublingual vaccines in actively immunosuppressed patients with systemic autoimmune disease
P.D.11.20
Particulate form of antigen and routes of immunization drive the magnitude and quality of HIV-specific mucosal immune responses in mice
P.D.11.21
Gut homing response as a marker of mucosal immunity to oral vaccines
P.D.11.22
Development of a magnetic bead based method to probe salivary humoral immune responses to oral consortia
P.D.11.23
Switching the sole CH1 domain of an antibody impacts antigen recognition and function
P.D.11.24
Expression Profile of Human Fc Receptors in Mucosal Tissue: implications for antibody-dependent cellular effector functions targeting HIV-1 transmission
J. Ochoa Grullón1, G. Candelas2, C. Morado2, M. Núñez-Beltrán1, A. Comins-Boo1, J. Jover2, S. Sánchez-Ramón1;
1
Department of Clinical Immunology, Hospital Clínico San Carlos, Madrid, Spain, 2Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain.
T. L. Vazquez1, L. Torrieri-Dramard1, F. Pitoiset2, B. Levacher1, J. Vigneron1, F. Brimaud1, D. Klatzmann2, B. Bellier2;
1
UPMC - INSERM U959, Paris, France, 2UPMC - INSERM U959 - CIC-BTi GHPS, Paris, France.
A. Dey1, A. Sinha2, R. K. Nandy2, S. Kanungo2, D. R. Kim1, T. F. Weirzba1, W. A. Petri3, C. Czerkinsky4;
1
International Vaccine Institute, Seoul, Korea, Republic of, 2National Institute of Cholera and Enteric Diseases, Kolkata, India, 3University of Virginia, Charlottesville, VA, United States, 4INSERM University of
Nice, Nice, France.
T. Madhwani, A. J. McBain;
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Greater Manchester, United Kingdom.
D. Tudor1,2,3, M. Kamassi1,2,3, D. David1,2,3, P. Tuffery4, M. Bomsel1,2,3;
1
Mucosal Entry of HIV-1 and Mucosal Immunity, Infection, Immunity, Inflammation Department, Cochin Institute, Université Paris Descartes, Paris, France, 2CNRS (UMR 8104), Paris, France, 3INSERM,
U1016, Paris, France, 4Molécules Thérapeutiques in silico (MTi), INSERM UMR S973 and RPBS, Université Paris Diderot, Paris, France.
H. M. Cheeseman, D. F. King, A. B. Evans, P. Ziprin, R. J. Shattock;
Chairpersons: Andreas Bergthaler; Vienna, Austria / Erika Jensen-Jarolim; Vienna, Austria
P.D.12.01
Immunological profile in rabbits experimentally infected with different antigenic variants of RHD (rabbit haemorrhagic disease) virus
P.D.12.02
Sodium octanoate improves the innate immune response of bovine mammary epithelial cells during Staphylococcus aureus internalization via TLR2
P.D.12.03
The porcine MHC - linked inheritance of particular SLA class I and class II haplotypes in purebred German Landrace pigs
P. Niedzwiedzka-Rystwej, B. Tokarz-Deptula, W. M. Deptuła;
University of Szczecin, Szczecin, Poland.
N. Alva-Murillo, I. Medina-Estrada, A. Ochoa-Zarzosa, J. E. López-Meza;
Universidad Michoacana, Facultad de Medicina Veterinaria y Zootecnia, Morelia, Mexico.
U. Gimsa1, C. S. Ho2, S. E. Hammer3;
1
Institute of Behavioural Physiology, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany, 2Gift of Life Michigan, Histocompatibility Lab, Ann Arbor, MI, United States, 3Institute of
Immunology, University of Veterinary Medicine Vienna, Vienna, Austria.
P.D.12.04 Characterization of the local and systemic T-cell response to Swine Influenza A virus infections
S. C. Talker1, H. C. Koinig2, M. Stadler1, K. H. Mair1, I. M. Rodriguez-Gomez1, R. Graage2, B. Wöchtl2, A. Ladinig2, I. Hennig-Pauka2, R. Dürrwald3, A. Saalmüller1, W. Gerner1;
University of Veterinary Medicine Vienna, Institute of Immunology, Vienna, Austria, 2University of Veterinary Medicine Vienna, University Clinic for Swine, Vienna, Austria, 3Viral Vaccines, Business Unit
Animal Health, IDT Biologika GmbH, Dessau-Roslau, Germany.
1
74
P.D.12.05
Identification of CD3+NKp46+ porcine lymphocytes with NK-cell characteristics that are recruited to the lung during early influenza infection
K. H. Mair1, M. Stadler1, S. C. Talker1, H. Forberg-Fossum2, A. K. Storset3, A. Müllebner4, J. C. Duvigneau4, S. E. Hammer1, A. Saalmüller1, W. Gerner1;
Institute of Immunology, Department of Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria, 2Department of Laboratory Services, Norwegian Veterinary Institute, Oslo, Norway,
Department of Food Safety and Infection Biology, Norwegian University of Life Sciences, Oslo, Norway, 4Institute of Medical Biochemistry, Department of Biomedical Sciences, University of Veterinary
Medicine Vienna, Vienna, Austria.
1
3
P.D.12.06 C-reactive protein in the blood serum of rabbits experimentally infected with five different strains of RHDV (rabbit haemorrhagic disease virus)
M. Malinowska, W. M. Deptuła, B. Tokarz-Deptuła;
P.D.12.07
Changes in the expression of gene encoding the TLRs 2,3,4 and cytokines IL-6, IL-8, IFN-γ, TNF-α in peripheral blood leukocytes of rabbits infected with RHDV
(haemorrhagic disease virus)
A. Trzeciak-Ryczek, B. Tokarz-Deptuła, W. M. Deptuła;
P.D.12.08 Immunological and genetic characteristics of European strains of RHD (Rabbit haemorrhagic Disease) virus
B. Hukowska-Szematowicz, B. Tokarz-Deptuła, W. M. Deptuła;
P.D.12.09 Dietary administration of Verbascum speciosum enhances innate immune responses of rainbow trout, Oncorhynchus mykiss
P.D.12.10
The role of IgA subtypes in infection by pathogenic vs. non-pathogenic forms of RHDV in the European rabbit
P.D.12.11
Expression of a CD8αα homodimers on porcine NK cells and CD4+ T-cells
P.D.12.13
Construction of a recombinant adenovirus expressing immunogenic protein e2 of the bovine viral diarrhea virus (BVDV) and evaluation of their immune responses
in Colombia
P. Sousa-Pereira1,2, T. Strive3,4, P. J. Eteves1,2,5, J. Abrantes1;
1
CIBIO, InBIO - Research Network in Biodiversity and Evolutionary Biology, Vairão, Portugal, 2Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal, 3Commonwealth
Scientific and Industrial Research Organisation, Ecosystem Sciences Division, Canberra, Australia, 4Invasive Animals Cooperative Research Centre, University of Canberra, Canberra, Australia, 5CITS - Centro
de Investigação em Tecnologias de Saúde, CESPU, Gandra, Portugal.
J. Weiss, C. Zabik, A. Saalmüller, W. Gerner, M. Patzl;
University of Veterinary Medicine, Vienna, Austria.
Tuesday
M. Aghapour1, K. Nofouzi1, A. Ezazi1, A. Tukmechi2, N. Sheikhzadeh3, M. Akbari4;
1
Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran, Islamic Republic of, 2Department of Pathobiology and Quality Control, Artemia and Aquatic Animals Research
Institute, Urmia University, Urmia, Iran, Islamic Republic of, 3Department of Food Hygiene and Aquatic Animals, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran, Islamic Republic of,
4
Agricultural, Medical and Industrial Research School, Nuclear Science & Technology Research Institute, Karaj, Iran, Islamic Republic of.
J. Jaime, D. Vargas, G. Ramírez, V. Vera;
Universidad Nacional de Colombia, Facultad de Medicina Veterinaria y de Zootecnia, Bogotá, Colombia.
Chairpersons: Simon Fillatreau; Berlin, Germany / Marije I. Koenders; Nijmegen, Netherlands (tbc)
P.D.13.01
A novel therapeutic approach for autoimmunity: PD-1 agonist
P.D.13.02
Prevention of FVIII inhibitor formation by ATX-F8-117 in humanized HLA-DR2tg mice
S. Shibayama, M. Imai, T. Shimbo, T. Tezuka, Y. Nakano;
Tsukuba Research Institute, Ono Pharmaceutical Co., Ltd., Tsukuba, Japan.
K. Pletinckx1, K. S. Nicolson2, H. Streeter2, W. Sanderson3, S. Aerts1, L. Jansson1, D. C. Wraith4,1;
Apitope International NV, Diepenbeek, Belgium, 2Department of Cellular and Molecular Medicine, University of Bristol School of Medical Sciences, Bristol, United Kingdom, 3Apitope Technology Ltd., Bristol
& Bath Science Park, Dirac Crescent, Emersons Green, Bristol, United Kingdom, 4Department of Cellular and Molecular Medicine, University of Bristol School of Medical Sciences,, Bristol, United Kingdom.
1
P.D.13.03
Programmed cell death-ligand 1 controls psoriatic inflammation by suppressing PD-1hiIL-17A+ T cells
P.D.13.04
LAG3+Foxp3- regulatory T cells induced by B cells alleviated joints inflammation in collagen induced arthritis
P.D.13.05
Combination blocking of IL-6 and IL-21 in experimental arthritis inhibits their redundant role in Th17-driven joint pathology
P.D.13.06
High plasmablast frequency and lymphocyte count define populations unresponsive to rituximab in rheumatoid arthritis
P.D.13.07
Repeated CD4+ T-cell depletion in patients with rheumatoid arthritis over multiple cycles of rituximab treatment
P.D.13.08
Immune response repression by tolerant CD4-derived soluble MHCII molecules
P.D.13.09
Antigen-specific TCR-modified Treg for treatment of EAE
P.D.13.10
Targeted inhibition of macrophage derived proinflammatory cytokines
J. Kim1,2, Y. Choi1, B. Lee3, M. Song4, C. Ban1, S. Kim2, J. Kim1, T. Kim5, S. Park6, H. Kim5, Y. Sung3,4, S. Kim2, E. Shin1;
1
Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of, 2Department
of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Genexine, Inc., Seongnam, Korea, Republic
of, 4Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Korea, Republic of, 5Department of Environmental Medical Biology, Institute of Tropical
Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of, 6Laboratory of Translational Immunology and Vaccinology, Graduate School of Medical Science and Engineering, Korea Advanced
Institute of Science and Technology, Daejeon, Korea, Republic of.
S. Y. Chen1, B. L. Chiang1,2;
1
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, 2Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan.
D. M. Roeleveld1, R. J. Marijnissen1, B. Walgreen1, M. Helsen1, L. van den Bersselaar1, C. Nickerson-Nutter2, F. van de Loo1, W. B. van den Berg1, M. I. Koenders1;
1
Radboud umc, Nijmegen, Netherlands, 2Pfizer Inc, Cambridge, MA, United States.
M. H. Stradner, C. Dejaco, K. Brickmann, W. B. Graninger, H. Brezinschek;
Medical University of Graz, Graz, Austria.
M. Lavielle1, D. Mulleman1,2,3, P. Goupille1,2,3, H. C. Sung2,3, H. Watier1,2,3, G. J. Thibault1,2,3;
1
CHRU, Tours, France, 2Universite François Rabelais, Tours, France, 3UMR CNRS 7292, Tours, France.
A. Giannaki, G. Papadogianni, I. Athanassakis;
Biology Department University of Crete, Heraklion Crete, Greece.
E. Kieback1,2, E. Hilgenberg3, U. Stervbo3, V. Lampropoulou3, P. Shen3, M. Bunse2, W. Uckert1,2, S. Fillatreau3;
1
Humboldt University, Berlin, Germany, 2Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany, 3German Arthritis Research Center, Immune Regulation Group, Berlin, Germany.
G. Efimov1,2, D. Shvarev1, O. Goriainova1,3, F. Rozov1, E. Beketova1, E. Shilov1, M. Drutskaya1, A. Kruglov1,4,5, S. Tillib3, S. Nedospasov1;
Engelhardt Institute of Molecular Biology and Lomonosov Moscow State University, Moscow, Russian Federation, 2Hematology Research Center, Moscow, Russian Federation, 3Institute of Gene Biology,
Moscow, Russian Federation, 4German Rheumatism Research Center, Berlin, Germany, 5Lobachevsky University, Nizhny Novgorod, Russian Federation.
1
P.D.13.11
Genetic variations in interleukin-6-signal transducer (IL6ST/gp130) may aid the prediction of tocilizumab therapy outcome in rheumatoid arthritis
P.D.13.12
Standardized derivate of bovine colostrum inhibits development of experimentally induced type 1 diabetes
P.D.13.13
Idiotypic network immunotherapy as a possible cure or prevention of autoimmune diabetes
P.D.13.14
IL-33 induces CD4+CD25highFOXP3+ regulatory T cells in ex vivo cultures of PBMCs from children with type 1 diabetes
C. Enevold1, B. Baslund1, L. Linde2, N. L. Josephsen3, U. Tarp3, H. Lindegaard4, S. Jacobsen1, C. H. Nielsen1;
1
Institute for Inflammation Research, Dept. of Rheumatology, Rigshospitalet, Copenhagen, Denmark, 2Department of Rheumatology, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark,
3
Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 4Department of Rheumatology, Odense University Hospital, Odense, Denmark.
T. Saksida, I. Nikolic, M. Vujicic, I. Stojanovic, S. Stosic-Grujicic;
Institute for Biological Research Sinisa Stankovic, Belgrade, Serbia.
C. H. Brogren;
The Bartholin Institute, Rigshospitalet, Copenhagen N, Denmark.
M. Ryba-Stanisławowska1, P. Werner1, M. Skrzypkowska1, A. Brandt2, J. Myśliwska1;
1
Department of Immunology, Medical University of Gdańsk, Gdańsk, Poland, 2Clinic of Pediatrics, Department of Diabetology and Endocrinology, Medical University of Gdańsk, Gdańsk, Poland.
75
P.D.13.15
Therapy with regulatory T cells preserves beta cell function in children with type 1 diabetes- 2 year follow-up
N. M. Marek- Trzonkowska1, M. Myśliwiec2, A. Dobyszuk3, M. Grabowska3, I. Techmańska2, J. Juścińska4, R. Owczuk5, A. Szadkowska6, P. Witkowski7, W. Młynarski6, P. Jarosz- Chobot8, A. Bossowski9, J.
Siebert10, P. Trzonkowski3;
1
Laboratory of Immunoregulation and Cellular Therapies, Department of Family Medicine, Medical University of Gdańsk, Gdańsk, Poland, 2Department of Pediatric Diabetology and Endocrinology, Medical
University of Gdańsk, Gdańsk, Poland, 3Department of Clinical Immunology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland, 4Regional Center of Blood Donation and Treatment,
Gdańsk, Poland, 5Department of Anesthesiology and Critical Care, Medical University of Gdańsk, Gdańsk, Poland, 6Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University
of Łódź, Łódź, Poland, 7Department of Surgery, Section of Transplantation, The University of Chicago, Chicago, IL, United States, 8Department of Pediatrics, Endocrinology and Diabetes, Medical University
of Silesia, Katowice, Poland, 9Department of Pediatrics Endocrinology and Diabetology, Medical University of Białystok, Białystok, Poland, 10Department of Family Medicine, Medical University of Gdańsk,
Gdańsk, Poland.
Chairpersons: Eric Tartour; Paris, France / Bruno Silva-Santos; Lisboa, Portugal
P.D.14.01
TLR9-mediated targeted A20 in vivo silencing potentiates antitumor immune response
F. C. Braun1, S. Thomas1, J. van den Brandt2, G. K. Przybylski3, K. Schmoeckel4, B. M. Bröker4, C. A. Schmidt1, P. Grabarczyk1;
University Medicine Greifswald, Molecular Hematology, Greifswald, Germany, 2University of Greifswald, Central Core & Research Facility of Laboratory Animals, Greifswald, Germany, 3Polish Academy of
Sciences, Institute of Human Genetics, Poznan, Poland, 4University of Greifswald, Institute of Immunology and Transfusion Medicine, Greifswald, Germany.
1
Tuesday
P.D.14.02
Generation of functionally active Mart1-specific CD8+ T cells from cord blood-derived T cells by using artificial antigen-presenting cells
P.D.14.03
SKOV3 cell artificially expressing CD137L, CD80 and p53 increased cytotoxicity effects of PBMCs
J. Kwoczek1, C. Bunse1, J. Lahrberg1, S. Tischer1, J. Hübner1, M. Oelke2, R. Blasczyk1, M. Sauer1, B. Eiz-Vesper1;
1
Hannover Medical School, Hannover, Germany, 2Johns Hopkins School of Medicine, Baltimore, MD, United States.
M. Jaberipour1, M. Habibagahi2, M. Razmkhah1, A. Hosseini1, F. Amirmoezi1, L. Roshandel1,3, H. Ghaznavi1, M. Shahbazi3, A. Ghaderi1,2;
1
Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of, 2Immunology Department, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of,
3
Medical Cellular & Molecular Research Center, Gorgan University of Medical Sciences, Gorgan, Iran, Islamic Republic of.
P.D.14.04 Redirecting immune subsets through genetic manipulation for enhancing adoptive immunotherapy
C. S. Yong1,2, J. A. Westwood1, C. Devaud1, P. K. Darcy1,2, M. H. Kershaw1,2;
1
Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Australia, 2Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
P.D.14.05
Transforming growth factor-β (TGF-β) confers a central memory-like phenotype to ex-vivo stimulated human T cells for viral/cancer Adoptive Immunotherapy
P.D.14.07
A new fusion receptor overcomes PD-1-mediated immunosuppression in adoptive T cell therapy
A. Dahmani, C. Carli, M. Richaud, M. Goupil, V. Janelle, M. Khalili, J. Delisle;
Centre de Recherche de l’Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.
F. Rataj, S. Grassmann, M. Chaloupka, C. Lampert, S. Wenk, F. Kraus, M. Rapp, P. Düwell, S. Rothenfußer, M. Schnurr, S. Endres, S. Kobold;
Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Internal Medicine IV, Ludwig-Maximilians-Universität München, Munich, Germany, Member of
the German Center for Lung Research, Munich, Germany.
P.D.14.08 Combined aerosolization of immunomodulators in the treatment of lung metastases
V. Le Noci1, M. Tortoreto2, A. Gulino3, C. Storti2, F. Bianchi1, N. Zaffaroni2, C. Tripodo3, E. Tagliabue2, A. Balsari1, L. Sfondrini1;
Università degli Studi di Milano, Milan, Italy, 2Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, 3Università degli Studi di Palermo, Palermo, Italy.
1
P.D.14.09 CD22 as a target for antibody therapy of resistant forms of childhood B-cell precursor acute lymphoblastic leukemia
D. Kuzilkova, V. Kanderova, T. Kalina, O. Hrusak, E. Mejstrikova;
CLIP (Childhood Leukaemia Investigation Prague), Department of Paediatric Haematology and Oncology, Prague, Czech Republic.
P.D.14.10
Deciphering CD20 immunogenicity to generate protective anti-tumor CD4+ and CD8+ T cells
P.D.14.11
Novel therapeutic strategies in breast cancer using genistein and apigenin
P.D.14.12
Development of a universal antibody-based T cell retargeting system for cancer immunotherapy
P.D.14.13
Focussing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb
S. Siberil1, B. Milcent1, Q. Riller1, C. Deligne1, M. Hamieh2, O. Toutirais3, J. Latouche2, J. Teillaud1;
1
Cordeliers Research Center, INSERM UMRS1138, Paris, France, 2Institute for Research and Innovation in Biomedicine (IRIB), INSERM U1079, Rouen University Hospital, Rouen, France, 3INSERM U919, Caen
University Hospital, Caen, France.
L. I. Brasoveanu, C. Hotnog, V. Roman, M. Mihaila, M. Bostan;
“Stefan S. Nicolau” Institute of Virology, Center of Immunology, Romanian Academy, Bucharest, Romania.
C. Arndt1,2, A. Feldmann1,2, S. Koristka1,2, M. Cartellieri1,2, M. von Bonin3, A. Ehninger4, M. Bornhäuser3, G. Ehninger1,3,4, M. Bachmann1,2,4;
1
Tumorimmunology, University Cancer Center Dresden, Dresden, Germany, 2Radioimmunology, Institute of Radiopharmaceutical Cancer Research, HZDR, Helmholtz-Zentrum Dresden-Rossendorf,
Dresden, Germany, 3Medical Clinic and Policlinic I, Dresden, Germany, 4GEMoaB Monoclonals GmbH, Dresden, Germany.
E. Bolaños-Mateo1, B. Weigelin2, A. Teijeira1, I. Martinez-Forero1, S. Labiano1, A. Azpilikueta1, A. Morales-Kastresana1, J. I. Quetglas1, E. Wagena2, A. Rodríguez1, L. Chen3, P. Friedl2, I. Melero1;
1
CIMA, Pamplona, Spain, 2Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Yale University School of Medicine, New Haven, CT, United States.
P.D.14.14 An optimized peptide vaccine strategy capable of inducing multivalent CD8 T-cell responses with potent antitumor effects
H. Cho1, S. Jung1, H. Sohn1, E. Celis2, T. Kim1,3;
1
Catholic Hematopoietic Stem Cell Bank, The Catholic University of Korea., Seoul, Korea, Republic of, 2Cancer Immunology, Inflammation and Tolerance Program, Georgia Regents University Cancer Center,
Augusta, GA, United States, 3Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of.
P.D.14.15
Targeting of Langherhans cells in cancer vaccination by Laser-assisted epidermal immunogen delivery
L. Buonaguro1, M. Tagliamonte1, A. Petrizzo1, M. Tornesello1, L. Circelli1, A. Luciano1, D. Rea1, A. Barbieri1, C. Arra1, C. Coscia2, F. M. Buonaguro1;
1
Istituto Nazionale Tumori, NAPLES, Italy, 2Pantec Biosolutions AG, Ruggell, Liechtenstein.
P.D.14.16 Vaccine-induced functional T cells targeting HER-2/neu in prostate cancer patients
E. A. Anastasopoulou, I. F. Voutsas, S. A. Perez, C. N. Baxevanis;
Cancer Immunology and Immunotherapy Center,St Savvas Cancer Hospital, Athens, Greece.
P.D.14.17
Tumorantigen-specific CD40B cells: Combining enhanced antigen-presentation and antibody-secretion for tumor targeting
K. Wennhold, M. Thelen, M. Garcia-Marquez, A. Shimabukuro-Vornhagen, M. von Bergwelt-Baildon;
Cologne Interventional Immunology, Department I for Internal Medicine, University Hospital Cologne, Cologne, Germany.
P.D.14.18 Generation of exhaustion-resistant memory CD8 T-cells by simultaneous downmodulation of mTORC1 and PD-1 in activated CD8 T-cells
A. Berezhnoy, A. Levay, A. Rajagopalan, Y. Dove, E. Gilboa;
University of Miami, Miami, FL, United States.
P.D.14.19 Longitudinal Effects of Ibrutinib Therapy on T Lymphocytes: Implications for Combination Adoptive Cell Strategies to Treat Chronic Lymphocytic Leukemia (CLL)
J. A. Fraietta1, K. A. Beckwith2, P. R. Patel1, S. E. McGettigan1, M. Ruella1, D. R. Cook1, J. Hulitt3, S. B. Kudchodkar1, A. P. Cogdill1, Z. Zheng1, J. J. Melenhorst1, D. L. Porter1, D. M. Barrett3, B. L. Levine1, C. H.
June1, J. C. Byrd2, M. V. Maus1;
1
University of Pennsylvania, Philadelphia, PA, United States, 2Ohio State University, Columbus, OH, United States, 3The Children’s Hospital of Philadelphia, Philadelphia, PA, United States.
76
P.D.14.20
Clinical efficacy of dendritic cells in combination with cytokine-induced killer cells in the treatment of advanced colorectal cancer
P.D.14.21
Correlating structure and molecular function of chimeric antigen receptors by advanced microscopy
P.D.14.22
The use of anchored agonists of phagocytic receptors for effective cancer immunotherapy
J. Zheng1, L. Jiang1, L. Yao1, Y. Ai1, Y. Zhang1, W. Huang1, Y. Gao1, C. Zhang1, H. Zhao1, S. Yu2, S. Jia1, J. Hu1;
1
Tumor Biotherapy Department of Hospital 81 of PLA, Nanjing, China, 2Oncology Department of Hospital 187 of PLA, Haikou, China.
V. Gudipati1, J. Rydzek2, M. Brameshuber3, A. Plach1, S. Königsberger1, M. Hudecek2, J. Huppa1;
1
Medical University of Vienna, Vienna, Austria, 2Universitätsklinikum Würzburg, Würzburg, Germany, 3Vienna University of Technology, Vienna, Austria.
V. Caisova1, A. Vieru1, Z. Kumzakova1, S. Glaserova1, H. Husnikova1, N. Vacova1, J. Kopecky1,2, J. Zenka1;
1
Department of Medical Biology, Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic, 2Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, v.v.i., Ceske
Budejovice, Czech Republic.
P.D.14.23
In vitro neutralization of IL-17A sensitizes dendritic cells to vinblastine in Langerhans cell histiocytosis
S. Olsson Åkefeldt1,2, M. Ismail2,3, A. Belot2,4, M. Lourda1, H. Valentin5,2, C. Maisse2,6, G. Salvatore2,7, N. Bissay2, M. Svensson1, M. Aricò8, J. Henter1, C. Delprat2,9;
Childhood Cancer Research Unit, Department of Women’s and Children’s Health, Karolinska Institutet, Center for Infectious Medicine, Karolinska University Hospital Solna, Stockholm, Sweden, 2CNRS,
UMR5239, Laboratoire de Biologie Moléculaire de la Cellule, Ecole Normale Supérieure de Lyon, Université de Lyon, Université de Lyon 1, Lyon, France, 3Laboratoire de microbiologie santé et environnement,
université Libanaise, Tripoli, Lebanon, 4Hôpital Femme Mère Enfant, Bron, France, 5UMR5239, Oullins, France, 6INRA-UCBL-ENVL, UMR 754, Rétrovirus et Pathologie Comparée, Lyon, France, 7Università
degli Studi di Firenze, Firenza, Italy, 8Azienda Sanitaria Provinciale 7, Ragusa, Italy, 9Institut Universitaire de France, Paris, France.
1
Chairpersons: Bastian Höchst; München, Germany / Maha Ayyoub; Nantes-Saint Herblain, France (tbc)
P.D.15.01
Construction of DNA vaccines expressing the novel tumor antigen neuroplastin: protective efficacy against mammary adenocarcinoma in immunized mice
A. Tiptiri-Kourpeti1, E. Poimenidis1, P. Ypsilantis2, C. Simopoulos2, V. Schirrmacher3, K. Chlichlia1;
Department of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis, Greece, 2Medical School, Democritus University of Thrace, Alexandroupolis, Greece, 3Immunology &
Oncology Center of Cologne, Cologne, Germany.
1
P.D.15.03
Exposure of blood mononuclear cells to BCG leads to enhanced recognition of bladder cancer cells by CD56bright NK cells
P.D.15.04
Development and characterization of Natural Killer T cell Vaccine for oral squamous cell carcinoma
P.D.15.05
dl922-947 virotherapy reduces IL-8 production and impairs anaplastic thyroid carcinoma-induced angiogenesis
E. M. García-Cuesta1, G. Esteso1, O. Ashiru2, M. Álvarez-Maestro3, S. López-Cobo1, A. Linares3, H. T. Reyburn1, M. M. Ho2, L. Martínez-Piñeiro3, M. Valés-Gómez1;
1
Spanish National Centre for Biotechnology, Madrid, Spain, 2National Institute for Biological Standards and Control, South Mimms, United Kingdom, 3Infanta Sofia Hospital, Madrid, Spain.
C. Passaro, F. Borriello, V. Vastolo, V. Cosimato, S. Di Somma, G. Marone, G. Portella;
University of Naples Federico II, Naples, Italy.
P.D.15.06 ChAdOx1-MVA vaccination platform as a novel prostate cancer immunotherapy
F. Cappuccini1, S. Stribbling1, E. Pollock1, C. A. Lygate2, C. Verrill3, A. V. Hill1, I. Redchenko1;
1
The Jenner Institute - University of Oxford, Oxford, United Kingdom, 2BHF Centre of Research Excellence, Division of Cardiovascular Medicine, John Radcliffe Hospital - University of Oxford, Oxford, United
Kingdom, 3Department of Cellular Pathology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Oxford, United Kingdom.
P.D.15.07
Tuesday
S. N. Das, A. K. Singh, N. K. Shukla;
All India Institute of Medical Sciences, New Delhi, India.
Foxp3-Fc (IgG) fusion construct/protein vaccination launches immune responses against regulatory T cells in mice
N. Mousavi Niri1, N. Zarghami1, J. Hajati2, A. Memarnejadian3, M. Aghasadeghi4;
1
Tabriz university of medical science, Tabriz, Iran, Islamic Republic of, 2Tehran university of medical science, Tehran, Iran, Islamic Republic of, 3Pasteur Institute of Iran, Tehran, Iran, Islamic Republic of,
4
Pasteur institute of Iran, Tehran, Iran, Islamic Republic of.
P.D.15.08 Evaluation of a Novel anti-Tumor Immunotherapeutic Strategy Targeting Regulatory T cells
R. Mustapha;
CNRS UMR 8161, Lille, France.
P.D.15.10
Efficient production of NY-ESO-1-specific CD4+ and CD8+ T-cell clones for epitope discovery and immunotherapy via activation marker expression
D. J. Verdon1,2, A. E. Brooks1,2, P. R. Dunbar1,2;
University of Auckland, Auckland, New Zealand, 2Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.
1
P.D.15.11
Affinity-optimized TCR-engineering of dual tumor- & virus- specific CD8 T cells for cancer immunotherapy
P.D.15.13
T-cell reconstitution after autologous hematopoietic stem cell transplantation with or without mesenchimal stromal cells co-infusion in patients with
hemoblastoses
M. Allard1, S. A. Fuertes Marraco2, P. O. Gannon1, M. Hebeisen1, D. E. Speiser1,2, N. Rufer1,2;
1
Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland, 2Ludwig Center for Cancer Research of the University of Lausanne, Lausanne,
Switzerland.
E. A. Blinova1, E. V. Batorov1, E. Y. Shevela1, V. V. Sergeevicheva2, I. V. Kruchkova2, A. V. Gilevich2, E. R. Chernykh1, V. A. Kozlov1;
1
Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russian Federation, 2Clinic of Immunopathology, Novosibirsk, Russian Federation.
P.D.15.14
STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
P.D.15.15
Polymer conjugates of cytotoxic drugs for tumor-specific drug delivery and anti-tumor immune responses
P.D.15.16
Fully synthesized Mucin 1 glycopeptides are effective cancer vaccines and induce high antigen-specific antibody titers
P.D.15.17
Investigating the role of dendritic cells in tumour immunotherapy with gene-modified T cells
P.D.15.18
Co-encapsulation of the invariant NKT cell agonist with antigen induces strong T cell-mediated anti-tumor immune responses
P.D.15.19
High throughput flow screening assays for immune checkpoint inhibitors: example assays for PD-L1/2 functional blocking antibodies
P.D.15.20
Alteration of CD4+ T cell subsets following multiple doses of DC-based vaccine in murine tumor model
O. Demaria1, A. De Gassart2, S. Coso2, N. Gestermann1, J. Di Domizio1, L. Flatz1, T. Petrova1, D. Speiser1, M. Gilliet1;
1
CHUV, Epalinges, Switzerland, 2UNIL, Epalinges, Switzerland.
M. Sirova1, T. Etrych2, M. Kabesova1, L. Sivak1, P. Chytil2, B. Rihova1;
1
Inst. of Microbiology ASCR, Prague 4, Czech Republic, 2Inst. of Macromolecular Chemistry ASCR, Prague 6, Czech Republic.
N. Stergiou1, B. Palitzsch2, R. Zentel2, E. Schmitt1, H. Kunz2;
1
Institute of Immunology, Mainz, Germany, 2Institute of Organic Chemistry, Mainz, Germany.
A. Hotblack, A. Holler, S. Ward, A. Piapi, H. Stauss, C. Bennett;
UCL, London, United Kingdom.
Y. Dolen1, M. Kreutz1, U. Gileadi2, J. Tel1, A. Vasaturo1, E. Dinther1, M. Hout-Kuijer1, V. Cerundolo2, C. Figdor1;
1
Radboud Institute for Molecular Life Sciences, Nijmegen, Netherlands, 2Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Z. Liu, T. Duensing, K. Luu;
IntelliCyt Corporation, Albuquerque, NM, United States.
A. Jamali1, A. Pourgholaminejad2, A. Amari2, J. Hadjati3;
Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 2Tarbiat Modarres University, Tehran, Iran, Islamic Republic of, 3Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
1
P.D.15.21
High Throughput Flow Screening Assays to Profile Cell-Mediated Killing
W. Johnson, R. Narang, K. Luu;
IntelliCyt Corporation, Albuquerque, NM, United States.
P.D.16 Immunotherapy for Infectious Diseases
Chairpersons: René Geyeregger; Vienna, Austria / Joel Edmundo Lopez-Meza; Morelia, Mexico
P.D.16.01 The heat-inactivated Actinomycetes modulate cell-mediated and humoral immunity in murine model
M. Aghapour1, K. Nofouzi1, K. Tahapour1, B. Ghahvechi2, B. Baradaran3, F. Mahmoodi3;
1
Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran, Islamic Republic of, 2Department of Microbiology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran,
P.D.16.03
Adoptive transfer of splenocytes to study cell mediated immune protection in influenza infected mice
C. Stavaru, A. Iancu, S. Ciulean;
Cantacuzino National Institute of Research-Development for Microbiology and Immunology, Bucharest, Romania.
P.D.16.04 Augmentation of anti-beta-glucan antibody by oral intake of edible mushroom and its role for excluding fungal infection
D. Yamanaka, K. Ishibashi, Y. Adachi, M. Motoi, N. Ohno;
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
77
P.D.16.05 Beneficial effects of soluble CD6 forms in experimental polymicrobial sepsis
M. Martínez-Florensa1, M. Consuegra-Fernández1, F. Aranda-Vega1, N. Armiger1, M. Di Scala2, L. Muñoz3, G. González-Aseguinolaza2, J. Vila3, F. Lozano1,4,5;
1
Institut de Investigacio Biomédica August Pi i Sunyer, Barcelona, Spain, 2Centro de Investigación Aplicada (CIMA), Universidad de Navarra, Spain, 3Barcelona Centre for International Health Research
CRESIB, Barcelona, Spain, 4Servei de Inmunología, Hospital Clinic, Hospital Clinic de Barcelona, Spain, 5Departament de Biología Cellular, Immunología i Neurociéncies , Facultat de Medicina, University of
Barcelona, Spain.
P.D.16.06 Optimizing the herpesvirus-specific CD8+ T-cell response by targeting the IL-10 receptor pathway
C. S. Lewis1, M. Clement2, D. C. Woods3, D. A. Price2, L. Wooldridge1, I. R. Humphreys2;
1
University of Bristol, Bristol, United Kingdom, 2Cardiff University, Cardiff, United Kingdom, 3University of Southampton, Southampton, United Kingdom.
P.D.16.07 Differential effects of Burkholderia bacteria and CpG on human myeloid and plasmacytoid dendritic cells
D. Reddi1, D. Bernardo1, H. Al-Hassi1, N. R. English1, R. Vora1, G. Han Lee1, P. Hendy1, G. Malietzis1, Y. Siaw1, A. L. Hart1,2, D. Williamson3, S. C. Knight1;
1
Antigen Presentation Research Group, Imperial College London, Harrow, United Kingdom, 2St. Mark’s Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom, 3Defence Science and
Technology Laboratory, Porton Down, United Kingdom.
P.D.16.08 A systematic review of preventive and therapeutic approaches to the Ebola virus
C. P. Atukpawu1, P. T. Ozoh2, I. O. Onyeocha2;
1
Department of Biotechnology, Federal University of Technology Owerri, Imo state, Nigeria, 2Federal University of Technology, Imo state, Nigeria.
P.D.16.09 Enhanced effectiveness of immunotherapy using anti-2kGy gamma irradiated Cerastes cerastes venom in the treatment of experimental envenomation
H. Oussedik-Oumehdi, S. Boumaiza, F. Laraba-Djebari;
USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology, Algiers, Algeria.
P.D.16.10 Immune status features in HCV contacts
Tuesday
Y. R. Sepiashvili1, I. P. Balmasova2, E. V. Malova2, R. I. Sepiashvili3;
1
Institute of Immunophysiology, Moscow, Georgia, 2Peopels Friendhip University, Moscow, Russian Federation, 3Institute of Immunophysiology, Moscow, Russian Federation.
P.D.16.11
A retrospective longitudinal within-subject analysis of immunoglobulin treatment for recurrent acute exacerbations of chronic obstructive pulmonary disease
J. Cowan1, L. Gaudet2, S. Mulpuru1,2, V. Corrales-Medina1,2, S. Hawken2, C. Cameron2, S. Aaron1,2, D. W. Cameron1,2;
1
University of Ottawa, Ottawa, ON, Canada, 2The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
P.D.16.12 Effect of avocado fatty acids and derivatives on the regulation of innate immunity in bovine mammary epithelial cells infected with Staphylococcus aureus
M. Báez-Magaña1,2, R. Salgado-Garciglia1, L. Macías-Rodríguez1, A. Ochoa-Zarzosa2, J. E. López-Meza2;
1
Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mexico, 2Centro Multidisciplinario de Estudios en Biotecnología-FMVZ, Morelia, Mexico.
P.D.16.13
Cell permeable Mx1 enhances protection against influenza virus infection
H. Jung, H. Lee;
P.D.16.14 Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys
Q. Pan, Q. Wang, X. Sun, X. Zhang;
Wuhan University School of Medicine, Wuhan, Hubei Province, China.
P.D.16.15
New immunotropic drugs for local treatment of inflammatory periodontal diseases
N. Sarkisian1,2,3, I. Tuzankina3,2, T. Khonina4, I. Shtanko4;
1
Ural state medical University, Ekaterinburg, Russian Federation, 2Institute of Immunology and Physiology of Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation, 3Ural
Federal University named after first President of Russia B. N. Yeltsin, Ekaterinburg, Russian Federation, 4I. Ya. Postovsky Institute of Organic Synthesis of Ural Branch of the Russian Academy of Sciences,
Ekaterinburg, Russian Federation.
P.D.16.16 Selection of adenovirus and Epstein-Barr-virus-specific T-cells with MHC class I streptamers under good manufacturing practice (GMP)-compliant conditions
C. Freimueller1, J. Stemberger1, M. Artwohl1, L. Germeroth2, V. Witt3, G. Fischer4, S. Tischer5, B. Eiz-Vesper5, T. Lion1, G. Fritsch1, R. Geyeregger1;
CCRI, Vienna, Austria, 24Stage Cell Therapeutics, Goettingen, Germany, 3St. Anna Children´s Hospital, Vienna, Austria, 4Department of Blood Group Serology and Transfusion Medicine, Vienna, Austria,
Institute of Transfusion Medicine, Hannover, Germany.
1
5
P.D.16.17
Immunotherapeutic potential of monophosphoryl lipid A (MPLA) on experimental paracoccidioidomycosis in mice
T. N. Landgraf, I. T. Brandão, A. P. Masson, W. C. da Silva, A. A. Coelho-Castelo, A. Panunto-Castelo;
P.D.16.18 Construction of pseudotype virus-like particles harbouring a functionally active Fc-engineered single-chain antibody against hepatitis B virus surface antigen
A. Zvirbliene1, M. Pleckaityte1, I. Kucinskaite-Kodze1, A. Gedvilaite1, C. M. Bremer2, D. Glebe2;
1
Institute of Biotechnology of Vilnius University, Vilnius, Lithuania, 2Institute of Medical Virology, Justus-Liebig University Giessen, Giessen, Germany.
P.D.16.19 BCG immunotherapy - a promising approach for treatment of recurrent respiratory papillomatosis
E. Vetskova1, M. Muhtarova1, T. Avramov2, M. Nikolova1;
1
National Center for Infectious and Parasitic Diseases, Sofia, Bulgaria, 2University Hospital for Active Treatment “Tsaritsa Joanna ”, Sofia, Bulgaria.
P.D.16.20 Different approaches to the conduct of interferon- and immunotherapy in viral and associated viral- bacterial infections of respiratory tract in
immunocompromised children
I. V. Nesterova1, V. V. Malinovskaj2, S. V. Kovaleva3, G. A. Chudilova3, L. V. Lomtatidze3;
The Russian People’s Friendship University, Moscow, Russian Federation, 2Federal Research Center of Epidemiology and Microbiology. N.F. Gamalei, Moscow, Russian Federation, 3Kuban State Medical
University, Krasnodar, Russian Federation.
1
P.D.16.21 EBV epitope-specific T cells expand in vivo following unselected donor lymphocyte infusion for post-transplant lymphoproliferative disease
D. Burns1, C. Harvey2, G. Ryan1, V. Sovani2, E. Nagy1, P. Murray1, C. Fox2, H. M. Long1;
1
University of Birmingham, Birmingham, United Kingdom, 2Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
P.D.16.22
The role of virus-specific CD4+ T cells in protective immunity against retrovirus infection
A. Malyshkina, I. Akhmetzyanova, U. Dittmer;
Institute for Virology University Hospital Essen, Essen, Germany.
Chairpersons: Diana Mechtcheriakova; Vienna, Austria / Henrique C. Teixeira; Juiz de Fora, Brazil
78
P.D.17.01
Antibodies to mitotic apparatus: New association with liver disease
P.D.17.02
Biomarkers of gut barrier damage as a tool for early diagnosis of necrotizing enterocolitis
P.D.17.03
ImmunExplorer (IMEX): A detailed analysis of the health status of the immune system using NGS immunoglobulin and T cell receptor IMGT HighV-QUEST data
P.D.17.04
Primary Membranous Nephropaty: Phospholipase A2 receptor (PLA2R) antibodies and clinical follow up
P.D.17.05
CXCL11 and IL-17 in bronchoalveolar lavage fluid and TGF-beta, TNF and CD69 in serum reflect severity and progression in sarcoidosis
P.D.17.06
The functional polymorphism in DARC gene regulating serum levels of CCL2/MCP-1 is associated with aseptic osteolysis of total joint replacements
V. Pascual, I. Perez-Enciso, P. Sánchez-Pobre, L. Fernández-Paredes, S. Sánchez-Ramón;
Hospital Clínico San Carlos, Madrid, Spain.
S. Coufal1, A. Kokesova2, H. Tlaskalova-Hogenova1, J. Nahlovsky2, M. Rygl2, J. Snajdauf2, M. Kverka1;
1
Institute of Microbiology, ASCR, v.v.i., Prague, Czech Republic, 2Department of Pediatric Surgery, 2nd Faculty of Medicine, Charles University in Prague, Teaching Hospital Motol, Prague, Czech Republic.
S. Schaller1, J. Weinberger2, R. Jimenez-Heredia2, M. Danzer3, S. Winkler1;
1
Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg i. M., Austria, 2Experimental and Clinical Traumatology, Ludwig Boltzmann Institute, Linz, Austria,
3
Immunogenetics Department, Red Cross Blood Transfusion Service of Upper Austria, Linz, Austria.
A. Llobell Uriel1, A. Mensa-VIlaró1, L. Rodas2, N. Martin3, X. Barros3, L. Rubio1, N. Pérez2, J. Campistol2, L. Quintana2, M. Blasco2, M. García Ormaechea1, O. Viñas-Gomis1;
1
Immunology Department, Hospital Clínic Barcelona, Barcelona, Spain, 2Nephrology Department, Hospital Clínic Barcelona, Barcelona, Spain, 3Nephrology Department, Hospital Josep Trueta, Girona,
Spain.
R. Fillerova1, T. Dyskova1, P. Schneiderova1, M. Zurkova2, V. Lostakova2, V. Kolek2, E. Kriegova1;
1
Dept. of Immunology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic, 2Dept. of Respiratory Diseases, Faculty of Medicine and Dentistry, Palacky University, Olomouc,
Czech Republic.
P. Schneiderova1, M. Vasinek2, P. Gajdos2, R. Fillerova1, J. Gallo3, E. Kriegova1;
1
Department of Immunology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic, 2Department of Computer Science, Faculty of Electrical Engineering and Computer Science,
VSB-Technical University of Ostrava, Ostrava, Czech Republic, 3Department of Orthopaedics, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
P.D.17.07
Exudate suction blister: A novel in vivo model of acute inflammation and resolution in humans.
M. Motwani1, R. De Maeyer1, D. Marks2, J. Fullerton1, A. Smith2, D. W. Gilroy1;
Centre for Clinical Pharmacology, Division of Medicine, University College London, London, United Kingdom, 2Centre for Molecular Medicine, Division of Medicine, University College London, London,
United Kingdom.
1
P.D.17.08
Time dependent alterations of monocyte HLA-DR expression, LPS induced TNF-alpha and IL-6 levels in whole blood in dependence of various anticoagulants and
different temperature conditions
J. Hartmann1, C. Lamm1, F. Preißing1, K. Dragosits1, A. Bee2, L. Wisgrill3, A. Spittler1,4;
1
Medical University of Vienna, Department of Surgery, Research Laboratories, Center of Translational, Vienna, Austria, 2University Clinic St. Pölten, St. Pölten, Austria, 3Medical University of Vienna,
Department of Pediatrics & Adolescent Medicine, Vienna, Austria, 4Medical University of Vienna, Core Facility Flow Cytometry, Vienna, Austria.
P.D.17.10
Autoantibody to MDM2:a potential serological marker of systemic lupus erythematosus associated with thrombocytopenia
P.D.17.11
Response to nasally delivered TLR agonists in normal adult volunteers
P.D.17.12
Increased frequency of circulating CD4+CD25+CD127low/neg T regulatory cells as a prognostic marker in patients with acute pancreatitis
P.D.17.13
Association of serum levels of vitamin D3 with TREM-1 and TREM-2 expressions on myeoid cell surfaces in pulmonary sarcoidosis patients
P.D.17.14
Whole-blood assays reveal inter-individual variations of innate and adaptive immune cell responses
P.D.17.15
Effectiveness of natalizumab in extended dosing interval
P.D.17.16
Choice of the tests for immunological monitoring of the slowed-down consolidation of bone fabric at damage
P.D.17.17
Development of a flexible, personalized multiplexing platform
P.D.17.18
Fit-for-purpose multiplex panels and their utility in biomarker screening
Y. Liu, G. Shi;
Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen, China.
A. Jha1, G. A. Campbell1, T. T. Hansel1, R. J. Shattock2, P. J. Openshaw1;
1
Centre for Respiratory Infections, National Heart and Lung Institute, Imperial College London, London, United Kingdom, 2Section of Infectious Diseases, Faculty of Medicine, St. Mary’s Campus, Imperial
College London, London, United Kingdom.
M. Bucova1, M. Suchankova1, E. Tibenska2, I. Majer3, E. Tedlova3, H. Novosadova3;
1
Institute of Immunology School of Medicine Comenius University, Bratislava, Slovakia, 2Medirex, ltd., Bratislava, Slovakia, 3Department of Pneumology and Phtisiology, Bratislava, Slovakia.
J. Dellacasagrande1, P. Apoil2,3, N. Congy2,3, B. Puissant2,3, A. Blancher2,3;
1
Blood Assay Solutions, Toulouse, France, 2EA 3034, Laboratoire d’immunogénétique Moléculaire, Université Toulouse 3, Toulouse, France, 3Laboratoire d’immunologie, CHU de Toulouse, Toulouse, France.
J. Puñet-Ortiz, J. Hervás, A. Teniente-Serra, M. Mansilla, B. Quirant-Sánchez, J. Navarro, E. Martínez-Cáceres, C. Ramo-Tello;
Germans Trias i Pujol University Hospital, Badalona, Spain.
Tuesday
K. S. Halacheva1, G. Minkov2, Y. Yovtchev2;
1
Trakia University, Medical Faculty, Stara Zagora, Bulgaria, 2University Hospital, Stara Zagora, Bulgaria.
O. V. Berdugina;
C. Lu, P. Liu, C. Smith, E. Kukreti, J. Han, L. Dzantiev, B. Sun, J. Zhang, D. Stewart, M. Higgins, C. Frye, J. Suschak, J. Kenten, S. Kumar, E. N. Glezer, G. B. Sigal, P. Oberoi, J. Wilbur, J. N. Wohlstadter;
Meso Scale Discovery (MSD®), Rockville, MD, United States.
D. Russell, J. Lewis, E. Spang, P. Oberoi, J. N. Wohlstadter;
P.D.18 Immunopharmacology
Chairpersons: Krzysztof Bryniarsky; New Haven, United States / Eric Vivier; Marseille, France
P.D.18.02 Autoantibodies able to penetrate into living cells are present not only in sera from patients with SLE but also in sera from healthy individuals and intravenous
Immunoglobulin preparations
A. D. Sali, I. Karakasiliotis, M. Evangelidou, S. Avrameas, P. Lymberi;
Hellenic Pasteur Institute, Athens, Greece.
P.D.18.03
Evaluation of the immunomodulatory activity of chitosan nanoparticles in human peripheral blood cells
J. M. Lima1,2, I. M. Rocha1,2, I. M. Fernandes1,2, E. G. Pires1,2, D. M. Dutra1,2, A. B. Sousa1, R. R. Sarmento1, J. R. Souza1,3, I. J. Porto4, R. F. Bonan1,2, F. A. Brayner5, J. E. Oliveira6, E. S. Medeiros4, P. R. Bonan1,2,7,
L. R. Castellano1,2;
1
Human Immunology Research and Education Group, Escola Técnica de Saúde da UFPB, Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil, 2Post-graduation Program in Dental Sciences,
Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil, 3Department of Physiology and Pathology, Center for Health Sciences, Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil,
4
Department of Materials Engineering, Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil, 5Centro de Pesquisas Aggeu Magalhães, CPqAM/FIOCRUZ and Laboratory of Immunopathology Keizo
Asami, Universidade Federal de Pernambuco, Recife Pernambuco, Brazil, 6Department of Engineering, Universidade Federal de Lavras, Lavras Minas Gerais, Brazil, 7Department of Clinical and Social
Dentistry, Center for Health Sciences, Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil.
P.D.18.04 Anti-proliferative activity of ruthenium (III) compounds on human colon tumor cell growth
A. Mihaila1, C. Hotnog1, M. Bostan1, V. Roman1, V. Uivarosi2, L. I. Brasoveanu1;
1
Institute of Virology, Bucharest, Romania, 2Inorganic Chemistry Dept., Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania.
P.D.18.05 Suppressive activity of novel derivatives of MPA
D. Iwaszkiewicz-Grzes1,2, G. Cholewinski2, M. Gliwinski1, K. Dzierzbicka2, P. Trzonkowski1;
1
Medical University of Gdansk, Gdansk, Poland, 2Gdansk University of Technology, Gdansk, Poland.
P.D.18.06 A novel ImageStream cytometry technique demonstrates the dexamethasone-induced nuclear translocation of glucocorticoid receptor in primary human
leukocytes
M. Kjerrulf, M. Nurkkala Karlsson;
Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden.
P.D.18.07 Phenotypic screenings to discover novel immunoregulators to treat inflammatory diseases
S. Frischbutter, O. Trupp, A. Schaus, V. D. Dang, I. Sakwa, S. Fillatreau, A. Hamann;
German Rheumatism Research Center, Berlin, Germany.
P.D.18.08 In vitro immunomodulatory properties of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide and its 01K and 06K derivatives
A. Drynda1, M. Zimecki2, E. Zaczyńska2, B. Obmińska-Mrukowicz1, M. Mączyński3, S. Ryng3;
1
Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Wrocław, Poland, 2Laboratory of Immunobiology,
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland, 3Department of Organic Chemistry, Faculty of Pharmacy, Wrocław Medical University, Wrocław, Poland.
P.D.18.09 Immunosuppressive activity of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide and its derivative (06K) in mouse in vivo models
A. Drynda1, M. Zimecki2, J. Arytm2, E. Zaczyńska2, B. Obmińska-Mrukowicz1, M. Mączyński3;
Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Wrocław, Poland, 2Laboratory of Immunobiology,
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland, 3Department of Organic Chemistry, Faculty of Pharmacy, Wrocław Medical University, Wrocław, Poland.
1
P.D.18.10 Paradigm shift in understanding the mechanism of IVIg: massive immune response against IgG interferes with efficient immune response against a specific
antigen
L. Sordé1, A. Karle1, S. Spindeldreher2;
1
Novartis Pharma AG, Basel, Switzerland, 2Novartis Institute for Biomedical Research, Basel, Switzerland.
P.D.18.11 A novel modulator of the antioxidant response pathway attenuates inflammatory response in macrophages
M. Obliers1, E. Collie-Duguid1, T. Morley2, H. M. Wilson1;
1
University of Aberdeen, Institute of Medical Sciences, Aberdeen, United Kingdom, 2Smith & Nephew, Research Centre Heslington, York, United Kingdom.
P.D.18.12 Buprenorphine, but not oxycodone, enhances humoral immune response in mice by activation of macrophages
I. Filipczak-Bryniarska1, K. Nazimek2, B. Nowak2, J. Woron1, J. Wordliczek1, K. Bryniarski2;
1
Department of Pain Treatment and Palliative Care Jagiellonian University College of Medicine, Krakow, Poland, 2Department of Immunology Jagiellonian University College of Medicine, Krakow, Poland.
P.D.18.13
GTW amelioratesimiquimod-induced skin lesions via a STAT3-dependent mechanism involving inhibition of Th17-mediated inflammatory responses
L. Ping, J. Zhao, T. Di;
79
P.D.18.14 Validation of neutrophil elastase assays using human whole blood or isolated neutrophils
F. Jiang, J. Mo, M. van Geest;
Astrazeneca, Mölndal, Sweden.
P.D.18.15
Effect of perioperative analgesia with opioid and non-steroidal anti-inflammatory drugs on the immune function of renal cancer patients
R. I. Sydor1,2, N. M. Khranovska1, I. I. Lisnyy1, O. V. Skachkova1, O. I. Gorbach1, E. O. Stakhovsky1, V. K. Pozur2;
1
National Cancer Institute of the Ministry of Public Health of Ukraine, Kyiv, Ukraine, 2Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.
P.D.18.16 Novel inhibitors of inflammatory mediators: derivatives of pyrimidine
Z. Zidek1, P. Jansa2;
1
Inst. Experimental Medicine, Acad. Sci., Prague, Czech Republic, 2Inst. Organic Chemistry and Biochemistry, Acad. Sci., Prague, Czech Republic.
P.D.18.17
Evaluation of the immunomodulatory activity of silver nanoparticles in human cells
A. B. Sousa1, C. L. Gouveia2, D. M. Dutra1,2, J. M. Lima1,2, I. M. Rocha1,2, I. M. Fernandes1,2, E. G. Pires1,2, R. R. Sarmento1, J. R. Souza1,3, I. J. Porto4, R. F. Bonan1,2, L. C. Alves5,6, L. H. Gil5, J. V. Silva Jr5, J. E.
Oliveira7, E. S. Medeiros4, P. R. Bonan1,2,8, L. R. Castellano1,2;
1
Human Immunology Research and Education Group, Escola Técnica de Saúde da UFPB, Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil, 2Post-graduation Program in Dental Sciences,
Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil, 3Department of Physiology and Pathology, Center for Health Sciences, Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil,
4
Department of Materials Engineering, Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil, 5Centro de Pesquisas Aggeu Magalhães, CPqAM/FIOCRUZ, Recife Pernambuco, Brazil, 6Laboratory of
Immunopathology Keizo Asami, Universidade Federal de Pernambuco, Recife Pernambuco, Brazil, 7Department of Engineering, Universidade Federal de Lavras, Lavras Minas Gerais, Brazil, 8Department of
Clinical and Social Dentistry, Center for Health Sciences, Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil.
P.D.18.18 Stephanthraniline A, a natural steroid from Stephanotis mucronata, inhibits immune responses of T cells in vitro and in vivo
X. Y. Li1, F. Y. Chen1, Y. P. Ye1, H. X. Sun2, S. F. Xu1;
1
Zhejiang academy of medical sceinces, Hangzhou, China, 2Zhejiang University, Hangzhou, China.
Tuesday
P.D.18.19 Skin rashes induced by vemurafenib are caused by a non-allergic mechanism
H. C. Friedrich1, P. A. Gerber1, A. Kislat1, K. Schindler2,3, N. Klossowski1, S. A. Braun1, P. Chapman2, M. E. Lacouture2, B. Homey1, S. Meller1;
1
Department of Dermatology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany, 2Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY,
United States, 3Department of Dermatology, Division of General Dermatology, Medical University of Vienna, Vienna, Austria.
P.D.18.21 Potential nitric oxide involvement in renal tissue protection in sevoflurane anesthetized rats pretreated with glibenclamide
M. I. Leite1,2,3, L. R. Castellano3, C. W. Pissetti4,3, P. T. Vianna1, Y. M. Castiglia1;
Departamento de Anestesiologia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu SP, Brazil, 2Serviço de Anestesiologia, Hospital Universitário Lauro Wanderley,
Universidade Federal da Paraíba, João Pessoa PB, Brazil, 3Human Immunology Research and Education Group, Escola Técnica de Saúde da UFPB, Universidade Federal da Paraíba, João Pessoa PB, Brazil,
4
Programa de Pós-Graduação em Atenção à Saúde, Universidade Federal do Triângulo Mineiro, Uberaba MG, Brazil.
1
P.D.18.22
Suppressive effect of β,β-dimethylacryloyl Alkannin on activated dendritic cells in a Imiquimod-induced psoriasis mouse model
Y. Wang, J. Zhao, P. Li;
Track E – Other
Chairpersons: Anne-Marie Buisman; Bilthoven, Netherlands / Florian Kern; Brighton, United Kingdom
80
P.E.02.03
Widespread seasonal gene expression reveals annual differences in human immunity and physiology
P.E.02.04
Integrative approach to the analysis of pathogenesis and the control of the within-host HIV infection dynamics
P.E.02.05
Analysis of Dendritic Cells in human lymphoid organs
P.E.02.07
Global high-resolution mapping of TTP-binding sites in the murine macrophage transcriptome during LPS-induced inflammation
P.E.02.08
A consolidation phase in immune memory
P.E.02.09
CD8+/CD28+ naïve T cells: a potential biomarker of immunosenescence and active vaccine responsiveness
P.E.02.11
Aging and infections: two burdens for T cells
P.E.02.12
Molecular and functional characterization of human circulating hematopoietic progenitors (HPC) subsets in elderly individuals
P.E.02.13
Disease complexity in acute coronary syndrome is related to the patient’s immunological status
P.E.02.14
Development of the vascular system in prenatal human skin
X. Castro Dopico1, M. Evangelou2, R. C. Ferreira2, H. Guo2, M. L. Pekalski2, D. J. Smyth2, N. Cooper2, O. S. Burren2, A. J. Fulford3, B. J. Hennig3, A. M. Prentice3, A. Ziegler4, E. Bonifacio5, C. Wallace2, J. A.
Todd2;
1
University of Cambridge & University of Edinburgh, Cambridge, United Kingdom, 2University of Cambridge, Cambridge, United Kingdom, 3MRC International Nutrition Group at MRC Unit The Gambia &
London School of Hygiene & Tropical Medicine, London, United Kingdom, 4Institute of Diabetes Research, Helmholtz Zentrum Munchen, Neuherberg, Neuherberg, Germany, 5CRTD—DFG Research Center
for Regenerative Therapies Dresden, Paul Langerhans Institute Dresden, Technische Universitat Dresden, Dresden, Germany.
V. A. Chereshnev1,2, G. A. Bocharov3,2, M. V. Chereshneva1;
1
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russian Federation, 2Ural Federal University, Yekaterinburg, Russian Federation, 3Institute of
Numerical Mathematics, Russian Academy of Sciences, Moscow, Russian Federation.
G. F. Heidkamp1, J. Sander2, N. Eissing1, L. Heger1, C. Lehmann1, A. Baranska1,3, J. Lühr1, A. Hoffmann1, S. Söder4, A. Hartmann4, J. Zenk5, M. Rudes6, C. Alexiou6, B. Spriewald7, A. Mackensen7, G. Schuler8,
B. Schauf9, S. Geiler9, R. Repp10, A. Purbojo11, R. Cesnjevar11, E. Ullrich12, F. Nimmerjahn13, J. Schultze2, D. Dudziak1;
1
University Hospital Erlangen, Department of Dermatology, Laboratory of Dendritic Cell Biology, Erlangen, Germany, 2LIMES – Life and Medical Sciences Center, Genomics and Immunoregulation, Bonn,
Germany, 3Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM-CNRS, Marseille-Luminy, France, 4University Hospital Erlangen, Department of Pathology, Erlangen, Germany,
5
Department of Otorhinolaryngology, Klinikum Augsburg Süd, Augsburg, Germany, 6University Hospital Erlangen, Department of Otorhinolaryngology, Erlangen, Germany, 7University Hospital Erlangen,
Department of Hematooncology, Erlangen, Germany, 8University Hospital Erlangen, Department of Dermatology, Erlangen, Germany, 9Department of Obstetrics and Gynecology, Sozialstiftung Bamberg,
Bamberg, Germany, 10Department of Hematology and Internal Oncology, Sozialstiftung Bamberg, Bamberg, Germany, 11University Hospital Erlangen, Department of Pediatric Heart Surgery, Erlangen,
Germany, 12Johann Wolfgang Goethe-Universität Frankfurt am Main, Center of Paediatrics and Youth Medicine, Medical Clinic III, Frankfurt am Main, Germany, 13Friedrich-Alexander Universität ErlangenNürnberg, Chairpersons: of Genetics, Department of Biology, Erlangen, Germany.
V. Sedlyarov1, J. Fallmann2, F. Ebner1, M. Ivin1, K. Kreiner1, A. Tanzer2, I. Hofacker2, P. Kovarik1;
1
Max F. Perutz Laboratories, University of Vienna, Vienna, Austria, 2Institute for Theoretical Chemistry, University of Vienna, Vienna, Austria.
F. Mantile1, A. Capasso1, P. De Berardinis2, M. Nicodemi3, A. Prisco1;
1
Institute of Genetics and Biophysics, Napoli, Italy, 2Institute of Protein Biochemistry, Napoli, Italy, 3University of Naples, Napoli, Italy.
M. Prcina1, Z. Kazmerova1,2, E. Kontsekova1,2, M. Novak1,2;
1
Axon Neuroscience, Bratislava, Slovakia, 2Institute of Neuroimmunology, Bratislava, Slovakia.
H. Kared;
SIgN, Singapore, Singapore.
T. Fali, V. Fabre, S. Fastenackels, V. Appay, D. Sauce;
CIMI-Paris Inserm U1135, Paris, France.
M. A. Moro García, F. López Iglesias, A. Echeverría, M. Iglesias Escudero, R. Alonso Arias;
Hospital Universitario Central de Asturias, Oviedo, Spain.
C. Schuster1, M. Mildner2, A. Botta1, L. Nemec1, R. Rogojanu3, L. Beer2, C. Fiala4, W. Eppel5, W. Bauer1, P. Petzelbauer6, A. Elbe-Bürger1;
1
DIAID, Department of Dermatology, Vienna, Austria, 2Research Division of Biology and Pathobiology of the Skin, Vienna, Austria, 3TissueGnostics GmbH, Vienna, Austria, 4Gynmed-Ambulatorium, Vienna,
Austria, 5Department of Gynaecology and Obstetrics, Vienna, Austria, 6Skin & Endothelium Research Division SERD, Vienna, Austria.
P.E.03 Metabolism & Immunity
Chairpersons: / Jona Freysdottir; Reykjavik, Iceland / Daniel Pennington; London, United Kingdom (tbc)
P.E.03.01
Characterization and isolation of camelide immune cell populations
P.E.03.02
The impact of chemotherapy on T-cell mitochondrial function
P.E.03.03
Elevated levels of IL-6 and IFN ᵧ in Iraqi patients with colorectal cancer
P.E.03.04
H63D/H63D genotype and H63D allele predispose patients with hyperferritinemia to develop metabolic syndrome
P.E.03.05
IL-6 and leptin in obese patients with taste alteration
P.E.03.06
Sedoheptulose kinase regulates the early phase of inflammation-associated reprogramming of carbohydrate metabolism
P.E.03.07
Functional interactions between systemic and intestinal immunity in human obesity
P.E.03.09
Study on the role of adipogenesis-related genes in the differentiation and immune regulatory activities of mesenchymal stem cell
P.E.03.10
Metabolic profiling of human monocytes and T cells
P.E.03.11
The role of AMP-activated protein kinase in T helper cell differentiation
P.E.03.12
metabolic requirements for neutrophil extracellular traps (NETs) formation
P.E.03.13
Role of Th17 cells-related cytokines in human obesity: inflammatory and metabolic impact in adipose tissue
P.E.03.14
Serum levels of IgA and IgG antibodies against gliadin and glutenin in obese subjects
P.E.03.15
ST2 deletion attenuates high fat diet-induced steatosis, inflammatory cell infiltration and collagen deposition in liver
P.E.03.16
Differential regulation of TNF receptor signaling during viral infection of hepatocytes determines cell death
P.E.03.17
Interaction between palmitate stimulated HEPG2 and monocytic cells reduces the expression of TNF-alpha
P.E.03.18
An insight on antibody-mediated immune-metabolism in inflammation and homeostasis: The role of Fc gamma receptors in regulation of Indoleamine 2,3
Dioxygenase Activity in Dendritic cells
M. Butze, D. Weschke, P. Holzlöhner, K. Hanack;
University of Potsdam, 14476 Potsdam, Germany.
H. Y. Wilson, S. Thirdborough, M. Edwards, C. Ottensmeier;
Southampton University Hospital, Southampton, United Kingdom.
H. A. Al-saadi;
Kerbala University, Kerbala, Iraq.
M. De Juan Echavarri1, L. Aragón1, A. Castiella2, E. Zapata3, L. Zubiaurre2, A. Iribarren2, P. Otazua4;
1
Immunology Hospital Donostia, Donostia San Sebastian, Spain, 2Gastroenterology, Mendaro Hospital,, Mendaro, Spain, 3Gastroenterology, Mendaro Hospital, Mendaro, Spain, 4Gastroenterology,
Mondragon Hospital., Mondragon, Spain.
C. Nagy1, A. E. Miller1, M. Schwaiger2, P. Kosma2, M. Sibilia1, T. Rülicke3, O. Wagner1, A. Haschemi1;
1
Medical University of Vienna, Vienna, Austria, 2University of Natural Resources and Life Sciences, Vienna, Austria, 3University of Veterinary Medicine, Vienna, Austria.
S. Touch1,2, A. Gestin1,2, M. Fradet2, L. Genser1,2,3, J. Aron-Wisnewsky1,2,3, C. Poitou1,2,3, E. Brot-Laroche4,2, K. Clément1,2,3, M. Guerre-Millo1,2, S. André1,2;
1
INSERM U1166 Team 6, Paris, France, 2Institute of Cardiometabolism And Nutrition, Paris, France, 3AP-HP Pitié Salpétrière Hospital, Paris, France, 4INSERM U1138 Cordeliers Research Center, Paris,
France.
Tuesday
N. Remla1, Z. Hadjidj1, S. Moulessehoul2, N. Akhtar Khan3, M. Aribi1;
1
Laboratory of Applied Molecular Biology and Immunology. University of Tlemcen, Tlemcen, Algeria, 2Laboratory of Biotoxicology, University of Sidi Bel-Abbès, 22000 Sidi Bel-Abbès, Sidi Bel-Abbès, Algeria,
3
UMR U866 INSERM, University of Burgundy, Dijon, France.
H. L. Kuo1, M. J. Fan-Jiang2, B. L. Chiang1,2;
1
Graduate Institute of Immunology, Collage of Medicine, National Taiwan University, Taipei, Taiwan, Taipei, Taiwan, 2Graduate Institute of Oral Biology School of Dentistry, Collage of Medicine, National
Taiwan University, Taipei, Taiwan, Taipei, Taiwan.
N. Jones;
Swansea University, SA2 8PP, United Kingdom.
G. A. Gualdoni1, K. A. Mayer1, L. Göschl2, M. Gerner3, K. G. Schmetterer3, G. J. Zlabinger1;
1
Institute of Immunology, Medical University of Vienna, Vienna, Austria, 2Department of Rheumatology, Internal Medicine 3, Medical University of Vienna, Vienna, Austria, 3Department of Laboratory
Medicine, Medical University of Vienna, Vienna, Austria.
O. Rodriguez-Espinosa, O. Rojas-Espinosa, M. M. Moreno-Altamirano, E. O. Lopez-Villegas, F. J. Sánchez-García;
Instituto Politécnico Nacional, México D. F., Mexico.
C. Caër1,2,3, C. Rouault1,2,3, K. Clément1,2,3, M. Guerre-Millo1,2,3, S. André1,2,3;
1
Sorbonne Universités, UPMC Université Paris 6, UMRS 1166 and UMRS 1138, Paris, France, 2INSERM, UMRS 1166, Nutriomics team 6, Paris, France, 3Institute of Cardiometabolism and Nutrition, ICAN,
Pitié-Salpêtrière Hospital, Paris, France.
M. Zrnic Ciric1, I. Stankovic1, S. Zilic2, M. Jankovic2, T. Srdic-Rajic3, A. Konic Ristic4;
1
Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia, 2Department of Food Technology and Biochemistry, Maize Research Institute, Belgrade-Zemun, Serbia,
3
Department of Experimental Oncology, Institute for Oncology and Radiology, Belgrade, Serbia, 4Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of
Belgrade, Belgrade, Serbia.
N. Jovicic1, I. Jeftic2, M. Miletic Kovacevic1, I. Tanaskovic1, N. Arsenijevic3, M. L. Lukic3, N. Pejnovic2;
1
Center for Molecular Medicine and Stem Cell Research, Institute of Histology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia, 2Center for Molecular Medicine and Stem Cell
Research, Institute of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia, 3Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences,
University of Kragujevac, Kragujevac, Serbia.
M. Janas1, M. Heikenwälder2, P. Knolle3, D. Wohlleber3;
1
Institutes of Molecular Medicine and Experimental Immunology, Bonn, Germany, 2Institute of Virology, Technische Universität München, München, Germany, 3Institute of Molecular Immunology,
Technische Universität München, München, Germany.
A. Nadeem, S. Sindhu, R. Ahmad;
Dasman Diabetes Institute, Kuwait, Kuwait.
H. Morsi1,2,3, F. Salazar2, A. Ghaemmaghami2;
1
king’s College Hospital, london, United Kingdom, 2Division of Immunology, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom,
3
Faculty of Medicine, University of Khatoum, Khartoum, Sudan.
P.E.03.19
Vitamın D Levels Of Turkish Children
P.E.03.20
The metabolic basis enabling tissue-recirculation of human effector memory CD4+ T cells
P.E.03.21
The comparison of A Single Bout Endurance and Resistance Training on HSP70 and Glucose
P.E.03.22
The influence of the joint supplementation of the diet by micronutrients (Routine and Hesperidin) on the immune system of rats
N. Isiksacan1, M. Koser2;
1
Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey, 2Mehmet Akif Ersoy Cardiology and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
S. Dimeloe1, M. Mehling1,2, C. Frick1, J. Loeliger1, G. R. Bantug1, U. Sauder1, M. Fischer1, R. Belle1, L. Develioglu1, S. Tay2, A. Langenkamp3, C. Hess1;
1
University of Basel, Basel, Switzerland, 2ETH Zurich, Basel, Switzerland, 3Roche Pharmaceutical Research and Early Development, Basel, Switzerland.
H. Poursadra1, F. Nameni2;
1
Financial Management, Dustan Equipment, Iran, Islamic Republic of, 2Dep. Physical Education, Varamin-Pishva Branch, Islamic Azad University, Iran, Islamic Republic of.
E. Trushina, O. Mustafina, L. Kravchenko, A. Balakina, N. Rieger, I. Alexeeva;
81
Wednesday, September 9, 2015
Wednesday
82
Wednesday
September 9, 2015
P.A.20 Dynamics of T Cell Activation and Contraction - Part 1
P.A.23 Costimulatory Pathways in Immunity and Tolerance
P.C.22 Complement and Fc Receptors
P.C.24 microRNAs and Epigenetics
P.D.19 Vaccines for Infectious Diseases
P.D.20 Vaccine Adjuvants
P.B.31 Secondary Immunodeficiencies
P.B.33 Environmental and Genetic Factors in Autoimmunity
P.B.34 Multiple Sclerosis
P.B.35 Immune Regulation at Barrier Sites - Part 1
P.B.36 Immune Regulation at Barrier Sites - Part 2
P.B.37 Cytokines in Regulation of Disease
Wednesday
P.A.28 Dynamics of T cell activation and contraction - Part 2
P.D.25 Organ Transplantation
P.D.26 Immunosuppressive and Tolerogenic Treatment
P.D.27 MHC and other Gene Polymorphisms in Health & Disease
P.B.40 Myelo-and Lymphoproliferative Disorders
Track E – Other
P.B.41 Atherosclerosis and Cardiovascular Diseases
P.E.05 Reproductive Immunology
83
Chairpersons: René Geyeregger; Vienna, Austria / Pierre Bobé; Orsay, France (tbc)
P.A.20.01
Adrenomedullin reduces the release of interleukin 6 from thymic epithelial cells by interacting with the canonical NF-kB pathway
P.A.20.02
miR-183/96 promotes AKT expression and proliferation upon activation of CD4+ T cells
P.A.20.03
The role of Lymphocyte-specific protein tyrosine kinase Lck in the process of T-cell-activation
P.A.20.04
T cell activation is centrally regulated by microRNA 155
P.A.20.05
Live Fast, Die Young: Urokinase receptor expressing T cells are adherent, hyper-reactive & undergo activation induced cell death
G. Paliuri1, G. Castellani1, G. Orso2, S. Bova1, S. De Martin1;
1
University of Padova, Dept. of Pharmaceutical and Pharmacological Sciences, Padova, Italy, 2Eugenio Medea Scientific Institute, Conegliano (TV), Italy.
J. Thiel, C. Alter, A. M. Westendorf, J. Buer, W. Hansen;
University Hospital Essen, Medical Microbiology, Essen, Germany.
C. Bonstingl, H. Stockinger;
Institute for Hygiene and Applied Immunology, Vienna, Austria.
E. Goncalves Alves1, V. Saferding1, A. Puchner1, R. Benson2, M. Kurowska-Stolarska2, J. Brewer3, C. Schliehe4, A. Bergthaler4, J. Smolen1, K. Redlich1, S. Blüml1;
1
Department of Rheumatology- Medical University of Vienna, Vienna, Austria, 2Institute of Infection, Immunity & Inflammation-University of Glasgow, Glasgow, United Kingdom, 3Institute of Infection,
Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, 4CeMM - Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
A. Zwirzitz1, K. Pfisterer1, V. Leksa2, A. Elbe-Bürger3, H. Stockinger1;
1
Institute for Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria, 2Laboratory of Molecular Immunology, Institute of Molecular Biology, Academy of Sciences, Bratislava,
Slovakia, 3Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology,, Medical University of Vienna, Vienna, Austria.
P.A.20.06 The BMP pathway participates in human naive CD4+ T cell activation and homeostasis
V. G. Martinez, R. Sacedón, L. Hidalgo, L. M. Fernández-Sevilla, A. Vicente, A. Varas;
Complutense University of Madrid, Madrid, Spain.
P.A.20.07
The late endosomal transporter CD222 directs the spatial distribution and activity of Lck
V. Leksa1, K. Pfisterer2, W. Paster2, V. Supper2, A. Ohradanova-Repic2, A. Zwirzitz2, C. Donner2, H. Stockinger2;
1
Slovak Academy of Sciences, Bratislava, Slovakia, 2MUW, Vienna, Austria.
P.A.20.08 Stress induced by hip fracture is associated with immune alterations in humans
C. Bayard1, H. Lepetitcorps1, M. Larsen1, V. Appay1, J. Boddaert2, D. Sauce1;
1
CIMI PARIS US1135, Paris, France, 2APHP Geriatrie, Paris, France.
Wednesday
P.A.20.09 The CXCL12-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells
M. Lettau, D. Kabelitz, O. Janssen;
Institute of Immunology, Christian-Albrechts-University, Kiel, Germany.
P.A.20.10
Nucleotide-induced membrane-proximal proteolysis controls the substrate specificity of T cell ecto-ADP-ribosyltransferase ARTC2.2
P.A.20.11
Determining the influence of cell adhesion and costimulation on T-cell antigen recognition
P.A.20.12
Unexpected roles for nTreg, digital inflammation, and TLR9 in the regulation of helper-independent CD8+ T cell responses
P.A.20.13
Intracellular dynamics of phosphatase of regenerating liver 1 in T lymphocytes
P.A.20.14
Deep TCR repertoire profiling after seasonal influenza vaccination
P.A.20.15
The interaction between osteopontin and T cells is implicated in the migration of T cells into adipose tissue and can be blocked with immunoglobulins
S. Menzel1, B. Rissiek2, P. Bannas3, T. Jakoby4, M. Miksiewicz1, N. Schwarz1, M. Nissen1, F. Haag1, A. Tholey4, F. Koch-Nolte1;
1
Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 3Department
of Diagnostic Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 4Institute of Experimental Medicine – AG Systematic Proteome Research, Christian-Albrechts-Universität,
Kiel, Germany.
I. Doel-Perez1, M. Brameshuber2, R. Platzer1, J. B. Huppa1;
1
Molecular Immunology Unit, Institute of Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria, 2Institute of Applied Biophysics, Technical University of Vienna, Vienna, Austria.
S. P. Schoenberger, L. Labarta Bajo, J. Dolina;
La Jolla Institute for Allergy and Immunology, La Jolla, CA, United States.
P. Castro-Sánchez1, R. Ramírez-Muñoz1, J. Muñoz2, P. Roda-Navarro1;
1
Universidad Complutense Madrid, Madrid, Spain, 2Center of Cytometry and Fluorescence Microscopy. UCM, Madrid, Spain.
M. V. Pogorelyy1, A. L. Sycheva1, E. A. Komech1, Q. Marcou2, Y. Elhanati2, T. Mora3, A. Walczak4, I. Z. Mamedov1, Y. B. Lebedev1;
1
Shemyakin–Ovchinnikov Institute of bioorganic chemistry RAS, Moscow, Russian Federation, 2Laboratoire de Physique Théorique, Ecole Normale Supérieure, Paris, France, 3Laboratoire de Physique
Statistique, Ecole Normale Supérieure, Paris, France, 4Laboratoire de Physique Théorique, Ecole Normale Supérieure , Paris, France.
B. Wanko1, K. Schuch1,2, A. Jürets1, N. Kavian-Jaromi2, N. Sommer1, V. Moreno-Viedma1, G. Staffler3, M. Zeyda1, T. M. Stulnig1;
Christian Doppler Laboratory for Cardio-Metabolic Immunotherapy and Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University, Vienna, Austria, 2FH Campus
Wien, University of Applied Sciences, Department Health, Section Biomedical Science, Vienna, Austria, 3AFFiRiS AG, Vienna, Austria.
1
P.A.20.16
Dynamics of human T cell repertoire in course of influenza vaccination and subsequent revaccination within a year
P.A.20.17
Macroautophagy in T cell function
A. L. Sycheva1,2, M. V. Pogorelyy1, E. A. Komech1, I. Z. Mamedov1, Y. B. Lebedev1;
1
Shemyakin–Ovchinnikov Institute of bioorganic chemistry RAS, Moscow, Russian Federation, 2Lomonosov Moscow State University, Moscow, Russian Federation.
D. Murera, J. Arnold, F. Arbogast, S. Muller, F. Gros;
Institut de Biologie Moléculaire et Cellulaire - UPR3572 CNRS, Strasbourg, France.
P.A.20.18 The protein tyrosine phosphatase PTPN22/Lyp is a novel regulator of integrin signaling in T cells
G. H. Cornish1, G. L. Burn1, L. M. Svensson2, R. Zamoyska3, A. P. Cope1;
1
Kings College London, London, United Kingdom, 2Lund University, Lund, Sweden, 3University of Edinburgh, Edinburgh, United Kingdom.
P.A.20.19
IL-7 enhances the responsiveness of CMV effectors
P.A.20.20
A single non-synonimous polymorphism of Toll Like Receptor 2 modifies a binding site for small ligands, alters Th1/Th17 and Treg polarization of T cells and
modifies clinic outcome of EAE
N. Terrazzini1, G. Morrow2, F. Kern2, S. Caserta2;
1
University of Brighton, Brighton, United Kingdom, 2BSMS, Brighton, United Kingdom.
G. Di Sante1,2, G. Migliara1, A. Piermattei1, M. Valentini1, S. Hayrabedyan3, M. Foti4, G. Constantin5, M. Geloso1, G. Delogu1, F. Ria1;
1
Università Cattolica del Sacro Cuore, Rome, Italy, 2Institute of Rheumatology Catholic University, Rome, Italy, 3Institute of Biology and Immunology of Reproduction at Bulgarian Academy of Sciences,
Sofia, Bulgaria, 4Università degli studi di Milano Bicocca, Milan, Italy, 5Institute of General Pathology - Università di Verona, Verona, Italy.
P.A.20.21
Assessing Immunogenetic Basis of Adaptive Response to Radiation
I. Kofiadi1, L. Alexeev1, G. Vikulov2, G. Goudima1;
1
FSBI “NRC Institute of immunology” FMBA of Russia, Moscow, Russian Federation, 2Scientific Information Center for Prophylaxis and Treatment of Viral Diseases, Moscow, Russian Federation.
Chairpersons: Balbino Alarcón; Madrid, Spain / Riitta Lahesmaa; Turku, Finland
84
P.A.21.01
Investigation of glucocorticoid-induced apoptosis in mouse thymocytes
P.A.21.02
Glucocorticoid synthesis in the thymus
L. Prenek, F. Boldizsár, T. Berki;
University of Pécs Medical School Department of Immunology and Biotechnology, Pécs, Hungary.
L. Rocamora-Reverte, A. Villunger, J. Wiegers;
P.A.21.03
Impact of the MHC-restricting allele expression on the human Ag-specific thymic T cell repertoire
L. Hesnard1,2, F. Legoux1,2, L. Gautreau1,3, M. Moyon1, M. Devilder1, M. Bonneville1, X. Saulquin1,3;
U892 CRCNA, nantes, France, 2equally contributed to this work, Nantes, France, 3Université Nantes, Nantes, France.
1
P.A.21.04
Expression and regulation of Human Endogenous Retroviruses during human T cell development
V. Mendes-Passos, A. E. Sousa, H. Nunes-Cabaço;
Instituto de Medicina Molecular, IMM, Lisboa, Portugal.
P.A.21.06 Nuclear receptor corepressor 1 (NCoR1) in T cell development and homeostasis
L. Müller1, H. Hassan1, D. Hainberger1, A. Villunger2, J. Auwerx3, W. Ellmeier1;
1
Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Division of Developmental Immunology,
Biocenter, Medical University of Innsbruck, Innsbruck, Austria, 3Laboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
P.A.21.07
CD3-delta controls positive selection of alpha-beta T cells by a quantitative developmental signaling mechanism
K. M. Wilton1, A. Huseby1, A. Ferrer1, M. M. Hoffmann1, P. J. Wettstein1, E. M. Carmona1, D. J. Kappes2, D. Gil1, A. J. Johnson1, A. H. Limper1, A. G. Schrum1;
1
Mayo Clinic College of Medicine, Rochester, MN, United States, 2Fox Chase Cancer Center, Philadelphia, PA, United States.
P.A.21.08 Molecular and functional analysis of a point mutation affecting the signaling function of CD5
G. Blaize1,2,3, F. Duguet1,2,3, A. Gonzalez de Peredo4, M. Marcellin4, M. Corre1,2,3, A. Saoudi1,2,3, P. Love5, R. Lesourne1,3,2;
1
CPTP - Inserm U1043, Toulouse, France, 2Université Paul Sabatier, Toulouse, France, 3CPTP - CNRS 5282, Toulouse, France, 4IPBS UMR CNRS/UPS 5089, Toulouse, France, 5Laboratory of Mammalian Genes
and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States.
P.A.21.09 Expression profiling of MAZR and its splicing variants in CD4+ helper T cells
A. Gülich, L. Andersen, A. Schebesta, S. Sakaguchi, W. Ellmeier;
Medical University Vienna, Vienna, Austria.
P.A.21.10
Efficient algorithm for computing the generation probability of an immune receptor nucleotide sequence
P.A.21.11
Effect of atopic and non-atopic IgG antibodies on αβT and γδT cells cytokine production in human thymus
P.A.21.12
Spatial regulation of Notch ligand expression in the human thymus defines specific functional microenvironments of TCRγδ cell development
P.A.21.13
CD6 expression influences thymocyte selection and development
P.A.21.14
Spontaneous development of thymic cell populations in long-term cultures of mouse and human thymuses
V. I. Nazarov1,2, M. V. Pogorelyy1, I. V. Zvyagin1, E. A. Komech1, I. Z. Mamedov1, Y. B. Lebedev1;
1
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation, 2National Research University Higher School of Economics, Moscow, Russian Federation.
F. R. Sgnotto, M. G. de-Oliveira, A. J. Duarte, L. Bento-de-Sousa, M. N. Sato, J. R. Victor;
School of Medicine - USP, Sao Paulo, Brazil.
M. Orta-Mascaró1, E. Carreras1, R. Roncagalli2, A. Carreras-Sureda3, L. Girard2, I. Simões1, V. Martínez1, M. Consuegra-Fernández1, M. Martínez-Florensa1, R. Vicente3, A. Sarukhan1, M. Malissen2, B.
Malissen2, F. Lozano1,4,5;
1
Institut de Recerca biomedica August Pi i Sunyer (IDIBAPS), Barcelona, Spain, 2Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, Marseille, France,
3
Universitat Pompeu Fabra, Barcelona, Spain, 4Servei d’Immunologia, Hospital Clínic de Barcelona, Barcelona, Spain, 5Departament de Biologia Cel•lular, Immunologia i Neurociències, Universitat de
Barcelona, Barcelona, Spain.
V. Shichkin1, N. Grabchenko1, N. Korotkevich1, O. Karpachova1, V. Glinka1, V. Sulyma1, I. Aksyonova1,2, B. Todurov1,2;
Research Centre of Immunology and Biomedical Technologies, Open International University of Human Development “Ukraine”, Kyiv, Ukraine, 2Institute of Heart, Ministry of Health of Ukraine, Kyiv,
Ukraine.
1
P.A.21.15
Thymic output in patients after autologous hematopoietic stem cell transplantation (autoHSCT) preceded by irradiation or high-dose chemotherapy based
conditioning
M. Głowala-Kosińska, A. Chwieduk, W. Fidyk, A. Smagur, I. Mitrus, J. Najda, S. Giebel;
1Department of Bone Marrow Transplantation and Oncohematology, Maria Sklodowska-Curie Memorial Cancer Center and Institute, Gliwice, Poland.
P.A.21.16
Wednesday
M. J. García-León1, L. Parreira2, M. L. Toribio1;
1
Centro de Biologia Molecular Severo Ochoa. CSIC-UAM, Madrid, Spain, 2Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Deciphering the mechanisms of thymic infection-induced tolerance
B. Cerqueira-Rodrigues1,2, P. Barreia-Silva1,2, C. L. Santos1,2, C. Nobrega1,2, M. Correira-Neves1,2;
1
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, 2ICVS/3B’s–PT Government Associate Laboratory, Braga/Guimaraes, Portugal.
Chairpersons: Diana Dudziak; Erlangen, Germany / Angelika Stöcklinger; Salzburg, Austria
P.A.22.01
A possible role of neutrophils in ige-mediated allergy
P.A.22.02
Differential effects of Parkinson-associated alpha-synuclein variants in human dendritic cells
P.A.22.03
Establishment and evaluation of a cellular, fluorescent-based, peptide-binding assay for the selection of altered peptide ligands (APL) of immunodominant
peptides of major pollen allergens
D. Polak, B. Nagl, C. Kitzmüller, B. Bohle;
S. Lopez1,2, C. Roodveldt1, C. Mayorga3, M. Blanca4, D. Pozo1,2;
1
CABIMER-Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, Spain, Seville, Spain, 2Department of Medical Biochemistry, Molecular Biology and Immunology, The University of
Seville Medical School, Seville, Spain, 3Research Laboratory, Carlos Haya Hospital-IBIMA, Malaga, Spain, 4Allergy Service Carlos Haya Hospital-IBIMA, Malaga, Spain.
M. R. Candia1, S. Rosskopf1, P. A. Tauber1, D. Trapin1, A. Neunkirchner1,2, P. Steinberger1, W. F. Pickl1,2;
Institute of Immunology, Center of pathophysiology, infectiology and immunology, Medical University, Vienna, Austria, 2Christian Doppler Laboratory for Immunomodulation, Center for Pathophysiology,
1
P.A.22.04
Amyloid form of Ovalbumin evokes native antigen specific immune response in the host: prospective immuno-prophylactic potential
P.A.22.05
Antidepressant drugs impair macrophage antigen-presenting activity
S. M. Faisal, S. Kazmi, M. Owais;
Interdisciplinary Biotechnology Unit, Aligarh Muslim University , Aligarh, India.
P. Bryniarski, M. Myszka, A. Bryk, M. Santocki, S. Strobel, A. Tyszka, P. Gniady, K. Nazimek;
P.A.22.06 Cross-tolerance versus cross-priming after miRNA-142-3p regulated transgene delivery with recombinant adeno-associated virus vectors
P. Chappert1,2, A. Ghenassia1,2, M. Carpentier1,2, S. Lorain3,4, D. A. Gross1,2, J. Davoust1,2;
1
INEM Inserm U1151 CNRS8253, Paris, France, 2Université Paris Descartes, Sorbonne Paris Cité, Paris, France, 3Institut de Myologie, INSERM U974 / CNRS FRE 3617, Paris, France, 4Sorbonne Universités,
UPMC Université Paris 06, Paris, France.
P.A.22.08 MARCH E3 ligases and novel ubiquitination events that shape immunity
J. Villadangos;
The University of Melbourne, Melbourne, Australia.
P.A.22.09 Antigens from mitochondria are not presented through the classical MHC class I pathway, but through a vacuolar pathway implicating Mitochondria Derived
Vesicles
D. Matheoud1, A. Sugiura2, A. Bellemare-Pelletier1, M. Azuma1, M. Chemali1, A. Laplante1, C. Rondeau1, A. Fazel2, J. Bergeron2, P. Thibault1, E. Gagnon1, H. McBride2, M. Desjardins1;
Université de Montréal, Montréal, QC, Canada, 2McGill University, Montréal, QC, Canada.
1
P.A.22.10
Antigen-presenting cells are required for antigen-specific suppression of murine contact sensitivity mediated by T cell-derived exosomes
P.A.22.11
ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides: a molecular understanding of peptide editing
P.A.22.12
ERAP1 regulates natural killer cell function by controlling the engagement of inhibitory receptors
K. Nazimek, M. Ptak, W. Ptak, K. Bryniarski;
M. Bouvier1, H. Chen1, L. Li1, M. Weimershaus2, I. Evnouchidou2, P. van Endert2;
1
University of Illinois at Chicago, Chicago, IL, United States, 2INSERM, Paris, France.
L. Cifaldi1, P. Romania1, V. D’Alicandro1, G. Guida1, M. Falco2, R. Meazza3, D. Pende3, F. Locatelli1, D. Fruci1;
Ospedale Pediatrico Bambino Gesù, Rome, Italy, 2Istituto Giannina Gaslini, Genoa, Italy, 3AOU San Martino-IST, Genoa, Italy.
1
85
P.A.22.13
TAPBPR associates with UDP-glucose:glycoprotein glucosyltransferase 1 to provide quality control in the MHC class I pathway
P.A.22.14
Altered expression of the ER aminopeptidase ERAP1 in HPV-induced malignancies
P.A.22.15
CD8 T cell epitope determination and immunogenicity enhancement by modulating antigen processing
P.A.22.16
Cross presentation pathway in murine alveolar epithelial cells against Mycobacterium bovis (BCG) infection.
P.A.22.17
Expression of Surface SpecificAntigen of echovirus and Establishment of Rapid Detection Technique
C. Hermann, R. Antrobus, L. H. Boyle;
University of Cambridge, Cambridge, United Kingdom.
A. Steinbach1, J. Winter1, A. K. Grabowska1, M. Reuschenbach2, S. Hoppe1,3, A. Klevenz1, R. Blatnik1,3, H. Khallouf1, M. von Knebel Döberitz2, A. B. Riemer1,3;
1
German Cancer Research Center, Heidelberg, Germany, 2Institute of Pathology, Heidelberg, Germany, 3German Center for Infection Research, Heidelberg, Germany.
A. C. Platteel, M. de Groot, A. J. Sijts;
Department of Infectious diseases and Immunology, Utrecht University, Utrecht, Netherlands.
Z. A. Rizvi1, N. Puri1, R. K. Saxena2;
1
Jawaharlal Nehru University, Delhi, India, 2South Asian University, Delhi, India.
S. Li1,2, Y. Qi1, T. Xu1,2, Y. Pan1, S. Li1, J. Li1, C. Chen1,3, X. Wang1,3, Y. Xu1,3, Y. Li1;
1
Huadong Research Institute for Medicine and Biotechniques,Nanjing210002, China, Nanjing, China, 2School of Basic Medicine, Nanjing Medical University, Nanjing 210005, China, Nanjing, China, 3School
of Life Science and Technology,China Pharmaceutical University,Nanjing 210009,China, Nanjing, China.
P.A.23 Costimulatory Pathways in Immunity and Tolerance
Chairpersons: Lucy S. Walker; London, United Kingdom / Peter Steinberger;Vienna, Austria
Wednesday
P.A.23.01
Blocking costimulatory signal for the treatment of steroid resistant asthma
P.A.23.02
Cloning and characterization of the CD40 extracellular domain from rhesus monkey
P.A.23.03
Bidirectional polarization of T cell function via CD43
P.A.23.04
Differential control of CD80 and CD86 on T-cells
P.A.23.05
New insights in CD28 T cell signaling and inflammation
P.A.23.06
Costimulation blockade by belatacept inhibits allo-specific T cell responses but preserves virus-specific memory T cell-responses in kidney transplant recipients
A. Mori1, S. Kouyama1, M. Yamaguchi1, Y. Iijima1, A. Ohtomo-Abe1, A. Kinoshita1, H. Hayashi1, K. Watai1, C. Mitsui1, C. Oshikata1, K. Sekiya1, T. Tsuburai1, M. Ohtomo1, Y. Fukutomi1, M. Taniguchi1, T. Ohtomo2,
O. Kaminuma3;
1
National Hospital Organization, Sagamihara National Hospital, Sagamihara, Japan, 2Tokyo University of Pharmacy and Life Science, Tokyo, Japan, 3Tokyo Metropolitan Institute of Medical Science, Tokyo,
Japan.
L. Wan, S. Zhu, H. Yang, J. Cheng, X. Lu;
Key Lab of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu, China.
M. Modak, O. Majdic, P. Cejka, P. Waidhofer-Söllner, S. Jutz, P. Steinberger, G. Zlabinger, J. Stöckl;
Institute of Immunology, Vienna, Austria.
B. Soskic1, L. E. Jeffery2, G. M. Hirschfield3, D. M. Sansom1;
1
Institute of Immunity and Transplantation, Royal Free Campus, University College London, London, United Kingdom, 2Medical Research Council Centre for Immune Regulation, School of Immunity and
Infection, Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom, 3Centre for Liver Research and National Institute for Health Research Biomedical Research Unit in Liver
Disease, Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom.
S. O. Morin1, M. Poggi2, V. Giroux1, C. Favre1, M. C. Alessi2, M. Malissen3, J. A. Nunès1;
1
Centre de Recherche en Cancérologie de Marseille - CRCM, Inserm U1068, CNRS UMR7258, Aix Marseille Université, Institut Paoli Calmettes, Marseille, France, 2Nutrition, Obésité et Risque Thrombotique NORT, Marseille, France, 3Centre d’Immunologie de Marseille Luminy - CIML, Marseille, France.
C. Neudörfl1, K. Daemen1, M. Stevanovic-Meyer1, F. Lehner2, H. Haller3, C. Blume4, G. Grannas2, C. S. Falk1;
Inst. of Transplant Immunology, Hannover Medical School, Hannover, Germany, 2Department of General, Visceral, and Transplantation Surgery, Hannover Medical School, Hannover, Germany,
Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany, 4Institute of Technical Chemistry, Leibniz University Hannover, Hannover, Germany.
1
3
P.A.23.07
The CD28/CTLA-4 - CD80/86 pathway in control of T cell activation
P.A.23.08
Requirement for IRF4-dependent DCs during generation of Th2 responses towards infection with the murine gastrointestinal nematode Trichuris muris
P.A.23.09
Costimulation through GITR enhances quantitative and qualitative CD4 T cell responses, leading to protective anti-viral CD8 T cell responses without exacerbating
pathology
V. Ovcinnikovs, R. Kenefeck, C. Wang, F. Heuts, A. Kogimtzis, H. Stauss, D. M. Sansom, L. S. Walker;
UCL, London, United Kingdom.
M. Demiri1, E. K. Persson1, W. W. Agace1,2, M. Svensson-Frej1;
1
Immunology, Lund, Sweden, 2Section of Immunology and Vaccinology, Frederiksberg, Denmark.
M. F. Pascutti1, S. Geerman1, E. Slot1, K. P. van Gisbergen1, L. Boon2, R. Arens3, R. A. van Lier1, R. A. van Lier1, M. C. Wolkers1, M. A. Nolte1;
1
Sanquin, Amsterdam, Netherlands, 2Bioceros BV, Utrecht, Netherlands, 3LUMC, Leiden, Netherlands.
P.A.23.10
Epithelium expressing the E7 oncoprotein of HPV16 attracts immune-modulatory dendritic cells to the skin
P.A.23.11
Prevention of Graft-vs-Host-Disease with maintenance of Graft-vs-Leukemia in humanized mice treated with an anti-ICOS monoclonal antibody
P.A.23.12
Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells
P.A.23.13
Selective CD28 blockade blunts memory lymphocytes responses in non human primates
P.A.23.14
Insights on the co-stimulatory role of TLR5 in neonatal CD4 T cells by means of computational modelling
P.A.23.15
The effect of co-stimulatory signals derived from acute myeloid leukemia cells (AML) on helper T lymphocyte activation and exhaustion
P.A.23.16
CD58/CD2 is the primary costimulatory pathway in human CD28- CD8+ T cells
P.A.23.17
Regulation of allergen-specific immune responses through the human members of the T cell immunoglobulin and mucin domain (TIM) family
P.A.23.18
Modulation of co-signals for generating allo-tolerant T-cells in humans
J. Chandra, Y. Miao, N. Romoff, I. H. Frazer;
University of Queensland, Woolloongabba, Australia.
A. Burlion1, N. Petit1, D. Olive2, G. Marodon1;
1
CIMI PARIS, PARIS, France, 2Paoli-Calmettes Institute, Marseille, France.
A. R. Sánchez-Paulete1, F. J. Cueto2, M. Martínez-López2, S. Labiano1, A. Morales-Kastresana1,3, M. E. Rodríguez-Ruiz4, M. Jure-Kunkel5, A. Azpilicueta1, Á. M. Aznar1, J. I. Quetglas1, D. Sancho2, I. Melero1,4;
1
Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, and Instituto de Investigación Sanitaria de Navarra (IdISNA), Pamplona, Spain, 2Centro
Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain, 3Current address: Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States, 4University Clinic,
University of Navarra and Instituto de Investigación Sanitaria de Navarra (IdISNA), Pamplona, Spain, 5Bristol-Myers Squibb Company, Princeton, NJ, United States.
N. Poirier1, M. Chevalier2, J. Hervouet2, D. Minault2, C. Mary1, P. Baker3, S. Ville2, S. Le Bas-Bernardet2, N. Dilek2, L. Belarif1, E. Cassagnau4, L. Scobie5, G. Blancho2, B. Vanhove1;
1
EFFIMUNE, Nantes, France, 2INSERM UMR 1064, Nantes, France, 3Glasgow university, Gaslgow, United Kingdom, 4CHU Hotel Dieu, Nantes, France, 5Glasgow university, Glasgow, United Kingdom.
O. Rodriguez Jorge1,2, L. Kempis Calanis1,2, D. Thieffry3, A. Santana Calderón1,2;
1
Universidad Autónoma del Estado de Morelos (UAEM), Cuernavaca, Mexico, 2Centro de Investigación en Dinámica Celular, Cuernavaca, Mexico, 3Institute de Biologie de L’Ecole Normale Supérieure
(IBENS), Paris, France.
D. Özkazanç, G. Esendağlı;
J. Leitner1, D. Herndler-Brandstetter2, G. J. Zlabinger1, B. Grubeck-Loebenstein2, P. Steinberger1;
1
Institute of Immunology, Vienna, Austria, 2Institute for Biomedical Aging Research, Universität Innsbruck, Austria.
A. Hennig, J. Leitner, S. Jutz, S. Rosskopf, P. Steinberger;
Institute of Immunology, MUW, Vienna, Austria.
B. Dillinger1, S. Ahmadi-Erber1, B. Vanhove2, A. M. Dohnal1;
Department of Immunology, Children’s Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria, 2Institut de Transplantation, INSERM, Nantes, France.
1
P.A.23.19
The role of the co-stimulatory receptor herpes virus entry mediator (HVEM) in B-cell activation and differentiation. Implications for SLE pathogenesis
A. Seretis1,2, A. Zampoulaki1,2, C. Choulaki1,2, I. Gergianaki1,2, P. Sidiropoulos2, D. Boumpas3,1, G. Bertsias1,2;
Laboratory of Autoimmunity & Inflammation, IMBB-FORTH, Heraklion, Greece, 2Rheumatology, Clinical Immunology and Allergy, University of Crete Medical School, Heraklion, Heraklion, Greece, 34th
Department of Internal Medicine, Attikon University Hospital, National University of Athens, Athens, Greece.
1
86
P.A.23.20
Identification of pathways indicative of allo-specific T-cell tolerance in murine stem cell transplantation
P.A.23.21
TGF-b1 controls skin homeostasis through the Vitamin K-dependent receptor tyrosine kinase Axl
P.A.23.22
Antigen presenting cell trafficking in murine lupus
S. M. Ahmadi1, S. Schrom1, B. Dillinger1, M. Laakso2, A. M. Dohnal1;
1
(1) Department of Immunology, Children’s Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria, 2Significo Research Oy, Helsinki, Finland.
T. Bauer;
Institute of Cancer Research, Medical University Vienna, Vienna, Austria.
M. R. Bono1, N. Crisostomo1, C. Fuentes1, A. Gleisner1, M. Rosemblatt1,2;
1
Universidad de Chile, Santiago, Chile, 2Fundacion Ciencia Vida, Santiago, Chile.
Chairpersons: Nicole Boucheron; Vienna, Austria / Francesco Annunziato; Florence, Italy
P.A.24.01
C-kit is regulated by aryl hydrocarbon receptor and is expressed on a subset of TH17 cells
P.A.24.02
ArtinM display different effects on murine T cells and human Jurkat T cells
P.A.24.03
Th22 and Th17 cells originate from distinct CD4+ T cell subsets and are dysregulated in Psoriatic Arthritis
K. A. de Lima, J. Talbot, P. B. Donate, T. Cunha, J. C. Alves-Filho, P. Louzada, F. Q. Cunha;
Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
T. A. da Silva, M. A. Souza, M. C. Roque-Barreira;
A. N. Ezeonyeji, H. M. Baldwin, M. Vukmanovic-Stejic, M. R. Ehrenstein;
P.A.24.04 B-1a cells stimulate T cells in producing IL-17 through IL-6
S. Y. Lin1, B. L. Chiang1,2;
1
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, Taipei, Taiwan, 2Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University,
Taipei, Taiwan, Taipei, Taiwan.
P.A.24.05
CCR7+ naïve and memory T lymphocyte detection in periodontitis-affected tissues
P.A.24.07
Blockade of Costimulation as an Option in the Treatment of Glomerulonephritis
K. Artinger1, A. H. Kirsch1, D. J. Cooper2, I. Aringer1, C. Schabhuettl1, P. Eller3, P. J. Lane2, A. R. Rosenkranz1, K. Eller1;
1
Clinical Division of Nephrology, Medical University of Graz, Graz, Austria, 2Medical Research Council Centre for Immune Regulation, Birmingham, United Kingdom, 3Intensive Care Unit at the Department
of Internal Medicine, Medical University of Graz, Graz, Austria.
P.A.24.08 EBI2 confers pathogenicity to Th17 cells
F. Wanke1, A. L. Croxford2, A. P. Heinen1, S. Moos1, S. Firmenich1, Y. Tang1, N. Israel1, K. Karram1, D. Tischner3, S. Reißig1, C. Reichhold1, I. Mufazalov1, T. Kuhlmann4, N. Wettschureck3, A. W. Sailer5, K.
Rajewsky6, S. Casola7, A. Waisman1, F. C. Kurschus1;
1
Institute for Molecular Medicine, Mainz, Germany, 2Institute of Experimental Immunology, Zürich, Switzerland, 3Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany, 4Institute of
Neuropathology, Münster, Germany, 5Novartis Institutes for BioMedical Research, Basel, Switzerland, 6Max-Delbrueck-Center for Molecular Medicine, Berlin-Buch, Germany, 7IFOM–The FIRC Institute for
Molecular Oncology, Milano, Italy.
P.A.24.09 The role of histone deacetylase 1 (HDAC1) in T helper 17 cells
L. Göschl1,2, T. Preglej1, L. Andersen1, P. Mathias3, C. Seiser4, G. Steiner2, W. Ellmeier1;
1
Department of Immunolgy, Medical University of Vienna, Wien, Austria, 2Department of Rheumatology, Medical University of Vienna, Wien, Austria, 3Friedrich Miescher Institute for Biomedical Research,
Basel, Switzerland, 4Max F. Perutz Laboratories, Medical University of Vienna, Wien, Austria.
P.A.24.10
Wednesday
C. Alvarez, L. Rojas, F. Castillo, P. Carvajal, A. Benítez, J. Díaz-Zuñiga, R. Vernal;
University of Chile, Santiago, Chile.
IkappaBNS, regulator of Th17 cell differentiation
M. Annemann1, Z. Wang2, C. Plaza-Sirvent3, R. Glauben4, M. Schuster3, F. Ewald Sander3, P. Mamareli2, A. A. Kühl4, B. Siegmund4, M. Lochner2, I. Schmitz3;
Institute for Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, Germany, 2Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection
Research, Hannover, Germany, 3Systems-Oriented Immunology and Inflammation Research Group, HZI Braunschweig, Germany and Institute for Molecular and Clinical Immunology, Otto-von-Guericke
University Magdeburg, Braunschweig, Germany, 4Medizinische Klinik I, Charité – Universitätsmedizin Berlin, Berlin, Germany.
1
P.A.24.11
Characterisation of IL-17A, IL-17F and IL-17E expression in human health and inflammatory disease
P.A.24.12
New tools for research on viable human IL-22- or GM-CSF-secreting T cells
P.A.24.13
Transcription factor Foxo1 directs the differentiation of IL-9+ T helper cells
L. A. Burns1, W. Cheng1, D. Marshall2, B. W. Kirkham3, L. S. Taams1;
1
Centre for Molecular & Cellular Biology of Inflammation, Division of Immunology, Infection and Inflammatory Disease, King’s College London, London, United Kingdom, 2UCB Pharma, Slough, London,
United Kingdom, 3Dept Rheumatology, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom.
D. S. Stolle, M. Niemöller, M. Vahldieck, M. Assenmacher, A. Richter;
Miltenyi Biotec GmbH, Bergisch Gladbach, Germany.
A. Awasthi, S. Malik, S. Sadhu, R. Pandey;
Translational Health Science & Technology Institute, Faridabad, India.
P.A.24.14 Retinoic Acid suppresses TH9 development by promoting Regulatory T Cell Differentiation
S. Malik1, R. Rampal2, V. Ahuja2, A. Awasthi1;
1
Translational Health Science & Technology Institute, Faridabad, India, 2All India Institute of Medical Sciences, New Delhi, India.
P.A.24.16 The role of IL-6 in the adaptive immune response against Listeria monocytogenes
K. Lücke1, J. Schwarz2, I. Yan1, V. Schumacher1, S. Rose-John2, A. Chalaris2, H. Mittrücker1;
1
University Medical Center Hamburg Eppendorf, Hamburg, Germany, 2Christian-Albrechts University, Kiel, Germany.
Chairpersons: Gisa Tiegs; Hamburg, Germany / Alexander Visekruna; Marburg, Germany
P.A.25.01
Hyperbaric Oxygen Therapy for a Murine Model of Arthritis
P.A.25.02
The enzymatic activity of IDO and TGF-beta establish tolerance and non-enzymatic IDO signalling and Tregs regulate the effector phase in type I IFN-mediated
protection against antigen-induced arthritis
H. Kim1, C. Eun-Jeong1, J. Mi-Seon1, K. Jeong-Hae2, S. Ju-Young1;
1
Department of microbiology, Ewha Womans Univiersity Medical Center, Seoul, Korea, Republic of, 2Pathology, National Health Insurance Cooperation Ilsan Hospital, Ilsan, Korea, Republic of.
J. Prakash Chalise1, M. T. Pallotta2, S. Chenna Narendra1, B. Carlsson1, A. Iacono2, S. Biggs1, J. Namale1, M. Magnusson1;
1
Linköping Universitet, Linköping, Sweden, 2University of Perugia, Perugia, Italy.
P.A.25.03
Insulin-like growth factor-1 mediated Treg induction modulates the immune response after tissue damage
P.A.25.04
Lipid metabolism affects regulatory T cell dynamics in cancer
P.A.25.05
CD39+ regulatory T cells control immune response against wild type HER2 but not mutated HER2 in breast cancer patients
P.A.25.06
The macrophage galactose-type c-type lectin (MGL) modulates regulatory T cell functions
S. Sattler1, B. Johanneson2, T. Kennedy-Lydon1, E. Gallego-Colon1, J. Tonkin1, D. Bilbao2, E. Semenova3, N. Rosenthal1;
1
Imperial College London, London, United Kingdom, 2European Molecular Biology Laboratory (EMBL), Monterotondo, Italy, 3Netherlands Cancer Institute, Amsterdam, Netherlands.
I. Pacella1, C. Focaccetti1, E. Timperi1, V. Barnaba1,2, S. Piconese1,2;
1
Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy, 2Istituto Pasteur - Fondazione Cenci Bolognetti, Rome, Italy.
S. Occhipinti1, A. Amici2, C. Marchini2, S. Bulfamante1, S. Bustreo3, M. Donadio3, C. Marchiò1, D. Pierobon1, F. Novelli1, M. Giovarelli1;
1
Universtiy of Turin, Turin, Italy, 2Universtiy of Camerino, Camerino, Italy, 3AOU Città della salute e della scienza, Turin, Italy.
I. Zizzari, P. Martufi, F. Battisti, H. Rahimi, S. Caponnetto, F. Bellati, M. Nuti, A. Rughetti, C. Napoletano;
Sapienza University of Rome, Rome, Italy.
87
Wednesday
P.A.25.07
Self-mediated shaping of naïve CD4 T cell effector fate
P.A.25.08
CD6 is required for proper T-cell activation during mouse allogeneic response
P.A.25.10
Fastest immunomagnetic enrichment of regulatory T cells from whole blood
P.A.25.11
Human natural regulatory T cells exhibit gender-associated variations
P.A.25.12
Expression of HLA-DR on natural regulatory T cells in pregnancy failure
P.A.25.13
The role of PGE2 in in vitro Treg differentiation
P.A.25.14
Clonal patterns in regulatory T cell subsets in APECED patients
P.A.25.15
Acute exercise effects on Treg cells and anti-inflammatory cytokines in master athletes
P.A.25.16
Modulation of the proliferative and suppressive activity of regulatory T cells by IL-2
P.A.25.17
Functionally impaired regulatory T cells in systemic sclerosis
P.A.25.18
Highly activated ST2+ Tregs accumulate at mucosal surfaces and strongly suppress CD4 T cell responses independent of IL-33 signals
N. Bonilla1,2, A. Durand1,2, B. Martin1,2, B. Lucas1,2, C. Auffray1,2;
1
Cochin Institute, Paris, France, 2CNRS UMR8104, INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France.
M. Consuegra-Fernández1, M. Martínez-Florensa1, F. Aranda1, J. de Salort1, N. Armiger-Borràs1, M. Orta-Mascaró1, E. Carreras1, P. Engel2, V. Martínez1, F. Lozano1,2,3;
1
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, 2Departament de Biologia Cel·lular, Immunologia i Neurociències, Universitat de Barcelona, Barcelona, Spain, 3Servei
d’Immunologia, Hospital Clínic de Barcelona, Barcelona, Spain.
P. Steinbrück, S. König, A. Richter, C. Dose;
Miltenyi Biotec GmbH, Bergisch Gladbach, Germany.
A. Velichkov1, R. Susurkova1, I. Antonova2, I. Manoylov3, G. Nikolov2, V. Terzieva1;
1
Institute of Biology and Immunology of Reproduction, BAS, Sofia, Bulgaria, 2Medical center for reproductive biology and medicine “RebroBioMed”, Sofia, Bulgaria, 3Institute of Microbiology, BAS, Sofia,
Bulgaria.
R. Susurkova1, A. Velichkov1, I. Manoylov2, I. Antonova3, G. Nikolov3, V. Terzieva1;
1
IBIR-BAS, Sofia, Bulgaria, 2Institute of Microbiology, BAS, Sofia, Bulgaria, 3Medical center for Reproductive Biology and Medicine “Reprobiomed”, Sofia, Bulgaria.
S. Crittenden, S. Anderton, S. E. Howie, C. Yao;
MRC Centre for Inflammation Research. University of Edinburgh, Edinburgh, United Kingdom.
T. T. Koivula, S. M. Laakso, H. J. Niemi, A. Tuulasvaara, E. Kekäläinen, T. P. Arstila;
Haartman Institute, Department of Bacteriology and Immunology, and Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland.
L. G. Minuzzi1, L. Rama1, F. Rosado1, A. Paiva2, A. Teixeira1;
1
University of Coimbra, Coimbra, Portugal, 2Portuguese Institute for Blood and Transplantation, Coimbra, Portugal.
J. Kie1, B. Moon2, J. Seoh2;
1
National Health Insurance Cooperation Ilsan Hospital, Koyang, Korea, Republic of, 2Ewha Womans University, Seoul, Korea, Republic of.
E. Ugor1, D. Simon1, K. Bodnár1, R. Pap1, P. Németh1, T. Minier2, L. Czirják2, T. Berki1;
1
University of Pécs Medical School Department of Immunology and Biotechnology, Pécs, Hungary, 2University of Pécs Medical School Department of Rheumatology and Immunology, Pécs, Hungary.
J. Siede1, A. Fröhlich1, A. Datsi1, A. N. Hegazy2, S. Nakae3, M. Löhning1;
1
Charité - DRFZ, Berlin, Germany, 2University of Oxford, Oxford, United Kingdom, 3University of Tokyo, Tokyo, Japan.
Chairpersons: Beatrice Jahn-Schmid; Vienna, Austria / Kim Klonowski; Athens, United States
P.A.26.01 Magnitude and kinetics of CD8+ T cell activation in hyperacute HIV infection impact viral set point
Z. M. Ndhlovu1,2, P. Kamya2, N. Mewalal1, T. Nkosi1, N. Ismail1, K. Dong2, T. Ndung’u1, B. D. Walker2;
1
University of KwaZulu Natal, Durban, South Africa, 2Ramon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.
P.A.26.02 Assessment of factors affecting lymphocyte activation in the neonate
F. Sava, A. Treszl, B. Vásárhelyi, G. Toldi;
First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
P.A.26.03
Memory T cell and plasma cell niches in the human bone marrow
L. Pangrazzi1, A. Meryk1, J. Lair2, B. Grubeck Loebenstein1;
1
University of Innsbruck, Innsbruck, Austria, 2Medical University of Innsbruck, Innsbruck, Austria.
P.A.26.04 Usage of memory T cell subpopulations for adoptive T cell therapy
A. Djordjevic, B. Mosetter, B. Frankenberger;
Institute of Molecular Immunology, Helmholtz Zentrum München, Munich, Germany.
P.A.26.05 Non-IPEX autoimmune enteropathy is associated with uncontrolled IL-17 production by intraepithelial lymphocytes
M. Paroni1, A. Magarotto2, G. Nizzoli1, U. Gianelli2,3, M. Pagani1, S. Abrignani1, D. Conte2,4, J. Geginat1, F. Caprioli2,4;
1
INGM, milano, Italy, 2Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy, milano, Italy, 3Pathology Unit, Fondazione IRCCS Cà Granda, Ospedale Policlinico
di Milano,, Milano, Italy, 4Gastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Policlinico di Milano, Milano, Italy.
P.A.26.06 Altered programming of anti-viral CD8 T cells by monocytes recruited to the lymph nodes after respiratory infection
H. Shane, K. Reagin, K. Klonowski;
University of Georgia, Athens, GA, United States.
P.A.26.07 A comparative assessment of the role of CD8+ T cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis
E. W. Brenu1,2, S. Broadley3,4, S. B. Ramos1,2, T. K. Huth1,2, D. R. Staines1,2, S. M. Marshall-Gradisnik1,2;
1
Natitional Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Southport, Australia, 2School of Medical Science, Griffith University, Southport, Australia,
3
School of Medicine, Griffith University, Southport, Australia, 4Gold Coast University Hospital, Queensland Health, Southport, Australia.
P.A.26.08 Paradigm violating HLA class II-restricted CD8 T cells exist in HIV infected individuals
S. Ranasinghe1, P. Lamothe-Molina1, D. Soghioan1, R. B. Jones1, J. Sidney2, A. Sette2, M. Carrington1, H. Streeck3, L. Picker4, D. E. Kaufmann1, B. D. Walker1;
1
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, United States, 2La Jolla Institute of Allergy and Immunity, La Jolla, CA, United States, 3MHRP, Silverspring, DC, United States, 4OHSU, Portland,
OR, United States.
P.A.26.09 Phenotype and function of CD8+ T cells activated by pMHCI-bearing lymphatic endothelial cells
E. Vokali1, S. Hirosue1, M. Rincon-Restrepo1, S. Scherer2, A. W. Lund1,3, P. Corthésy-Henrioud1, A. Mondino4, S. Hugues5, D. Zehn2, M. A. Swartz1;
1
Laboratory of Lymphatic and Cancer Bioengineering (LLCB), Institute of Bioengineering (IBI), School of Life Sciences (SV), Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland, 2Swiss
Vaccine Research Institute, Centre des laboratoires d’Epalinges, Epalinges, Switzerland, and the Division of Immunology and Allergy, Department of Medicine, Lausanne University Hospital, Lausanne,
Switzerland, 3Swiss Institute for Experimental Cancer Research (ISREC), Lausanne, Switzerland, 4Lymphocyte Activation Unit, Program in Immunology and Bio-Immunotherapy of Cancer, Division of
Immunology, Transplantation and Infectious Disease, San Raffaele Scientific Institute, Milan, Italy, 5Faculty of Medicine, Department of Pathology, Centre Médical Universitaire, Université de Genève,,
Geneva, Switzerland.
P.A.26.10 Expression of human leukocyte receptor FCRL6 associates with activated rather than exhausted CD8 T cell phenotype in chronic and acute viral infection
L. Mechetina1, S. Kulemzin1, Y. Sokolov2, L. Badaliyan3, N. Chikaev1, A. Najakshin1, E. Reshetnikova1, O. Volkova1, A. Taranin1;
Institute of Molecular and Cellular Biology, Novosibirsk, Russian Federation, 2AIDS Centre, Novosibirsk, Russian Federation, 3Central Hospital, Department of Infectious Diseases, Berdsk, Russian
Federation.
1
P.A.26.12
Fingolimod targeting protein phosphatase 2A differentially affects IL-33-induced IL-2 and IFN-γ in CD8+ lymphocytes
P.A.26.13
Defining highly cytotoxic CD8+ T cell subsets by flow cytometry and a real-time cytotoxicity assay
F. Ottenlinger, A. Schwiebs, K. Pfarr, A. Wagner, J. M. Pfeilschifter, H. H. Radeke;
pharmazentrum Frankfurt, Frankfurt am Main, Germany.
A. Knörck, K. S. Friedmann, C. Hoxha, M. Hoth, E. Schwarz;
Department of Biophysics, Homburg, Germany.
P.A.26.14 Expression of functional natural cytotoxicity receptors on peripheral blood CD8+ T cells
M. Correia, A. Stojanovic, K. Bauer, A. Cerwenka;
DKFZ, Heidelberg, Germany.
88
P.A.26.15
NKG2D-dependent innate-like cytotoxicity of activated CD8+ T cells in acute hepatitis A
J. Kim, D. Chang, P. Sung, E. Shin;
P.A.26.16 Analysis of in vitro generated pp65-specific CD8+ T-cell clones using a novel real-time killing assay
K. S. Friedmann1, A. Knörck1, C. Hoxha1, C. Kummerow1, B. Qu1, I. Müller2, H. Eichler2, M. Hoth1, E. C. Schwarz1;
1
Saarland University, Biophysics, CIPMM, Homburg, Germany, 2Saarland University, Clinical Hemostaseology and Transfusion Medicine, Homburg, Germany.
P.A.26.17
Characterization of the CD8+ T cell response to allergens
N. Samadi1, C. Kitzmüller1, B. Bohle1, R. Geyeregger2, B. Jahn-Schmid1;
1
Department of Pathophysiology and Allergy Research Medical University of Vienna, Vienna, Austria, 2Children’s Cancer Research Institute, Vienna, Austria, Vienna, Austria.
P.A.26.18 Strong CD8+ T cell cross-reactivity between influenza A virus M1-58 and a subdominant HCV epitope
S. Zhang, V. Schlaphoff, M. P. Manns, H. Wedemeyer, M. Cornberg, P. V. Suneetha;
Hannover medical school, Hannover, Germany.
P.A.26.19 Two distinct species of lysosome-related cytotoxic effector vesicles in activated human T cells
O. Janssen, L. Drews, T. Poch, H. Ebsen, H. Schmidt, D. Kabelitz, M. Lettau;
Institute for Immunology UKSH Campus Kiel, Kiel, Germany.
P.A.26.20 Self-tolerant CD8+ T cells are transcriptionally distinct from ‘exhausted’ T cells
K. Bhatt, T. Kenna, P. Leo, G. Thomas, R. Steptoe;
UQ Diamantina Institute, Brisbane, Australia.
P.A.26.21
Adaptive immunity and rs12979860 IL28B polymorphism in chronic hepatitis C patients treated with pegIFNα/RBV
N. I. Rallón1, J. García-Samaniego2, A. Madejón2, E. de la Vega3, L. Cortejoso4, M. Romero5, L. Martín-Carbonero5, J. M. Benito1;
1
IIS-Fundación Jiménez Díaz, UAM, Madrid, Spain, 2Hospital Carlos III-La Paz, CIBERehd, Madrid, Spain, 3Hospital carlos III-La Paz, Madrid, Spain, 4Hospital General Universitario Gregorio Marañón,
Madrid, Spain, 5Hospital Carlos III-La Paz, Madrid, Spain.
Chairpersons: Marta Rizzi; Freiburg, Germany / Wolfgang Schuh; Erlangen, Germany
P.A.27.01
Role of FAS signalling in negative selection of B cells in human germinal centres
P.A.27.02
EFhd1 regulates metabolic activity and influences early B cell development
P.A.27.03
The Polycomb Repressive Complex 1 is critical for peripheral B cell maturation and to ensure B cell identity
M. Stein1, S. Dütting1, W. Schuh1, T. Steinmetz1, S. Urbanczyk1, D. Mougiakakis2, H. Jäck1, M. R. Bösl3, D. Mielenz1;
1
Division of Molecular Immunology, Nikolaus-Fiebiger-Centre, University hospital Erlangen, Erlangen, Germany, 2Division of translational tumor and transplantation immunology, TRC, University hospital
Erlangen, Erlangen, Germany, 3Division of Biomedicine, University clinic Wuerzburg, Erlangen, Germany.
S. Casola1, F. Alberghini1, F. Zanardi1, L. D’Artista1,2, F. Pisati3, F. Mainoldi1, M. Vidal4, H. Koseki5;
1
IFOM, Milano, Italy, 2European Institute of Oncology, Milan, Italy, 3Cogentech, Milano, Italy, 4Centro de Investigaciones Biológicas, Department of Cellular and Molecular Biology, Madrid, Spain,
Developmental Genetics Laboratory; RIKEN-IMS, Yokohama, Japan, Yokohama, Japan.
5
P.A.27.04
Effect of bacterially derived products on B cell activation
P.A.27.05
The role of hedgehog protein signalling in B cell development
P.A.27.06
Dissecting the role of surface IgD in individuals with heterozygous IgD deficiency
P.A.27.07
Rise in total IgE levels upon omalizumab treatment is not caused by activation of IgE+ memory B cells
P.A.27.08
IL21 deficiency results in early-onset inflammatory bowel disease and common variable immunodeficiency-like disease
P.A.27.09
Prioritization of the IgH 3’ regulatory region: proximal and distal domains feature distinct functions
K. Qazi Rahman;
Stockholm University, Stockholm, Sweden.
Wednesday
A. Janda1, K. Schwarz2, M. van der Burg3, W. Vach1, H. Ijspeert3, M. R. Lorenz2, M. Magdeldin1, K. Pieper1, P. Fisch1, J. Hagel1, R. Lorenzetti1, M. Seidl1, J. Roesler4, F. Hauck5, E. Traggiai6, C. Speckmann1, A.
Rensing-Ehl1, S. Ehl1, H. Eibel1, M. Rizzi1;
1
University Medical Center Freiburg, Freiburg, Germany, 2University of Ulm, Ulm, Germany, 3Erasmus MC, Rotterdam, Netherlands, 4University Clinic Carl Gustav Carus, Dresden, Germany, 5LudwigMaximilians-University, Munich, Germany, 6Novartis Institute for Biomedical research, Basel, Switzerland.
C. E. Umukoro1,2, S. V. Outram1,2;
1
University of East London, London, United Kingdom, 2School of Health, Sports and Bioscience, London, United Kingdom.
J. Nechvatalova1, S. J. Bartol2, Z. Chovancova1, M. Vlkova1, J. Litzman1, M. C. van Zelm2;
1
Department of Clinical Immunology and Allergology, St Anne´s University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic, 2Department of Immunology, Erasmus MC,
University Medical Center, Rotterdam, Netherlands.
J. Eckl-Dorna1, R. Froeschl1, C. Lupinek1, R. Kiss1, K. Marth1, R. Campana1, K. Blatt1, P. Valent1, R. M. Selb1, A. Mayer1, I. Steiner1, P. Gevaert2, R. Valenta1, V. Niederberger1;
1
Medical University Vienna, Vienna, Austria, 2Ghent University Hospital, Ghent, Belgium.
E. Salzer1, A. Kansu2, H. Sic3, A. Ikinciogullari4, P. Majek1, F. E. Dogu4, E. Santos-Valente1, S. Ban1, W. Pickl5, J. Colinges1, M. Rizzi3, H. Eibel3, K. Boztug1,6;
1
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, 2Pediatric Gastroenterology Department Ankara University, Ankara, Turkey, 3Center for Chronic
Immunodeficiency, University Medical Center, Freiburg, Freiburg, Germany, 4Pediatric Immunology Department Ankara University, Ankara, Turkey, 5Christian Doppler Laboratory for Immunomodulation and
Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 6Department of Pediatrics and Adolescent Medicine, Medical University of
Vienna, Vienna, Austria.
E. F. Pinaud1,2, A. Garot1, M. Marquet1, S. Le Noir1, A. Saintamand1, S. Bender3, O. Martin1, C. Carrion1, Z. Oruc1, Y. Denizot1, M. Cogné1;
CNRS UMR7276 CRIBL, Limoges, France, 2Université de Limoges, Limoges, France, 3Centre Hospitalier Universitaire Dupuytren : Centre de Référence des Amyloses, Limoges, France.
1
P.A.27.10
A plasma cell differentiation quality control process ablates B-cell clones with biallelic Ig rearrangement and truncated Ig production
P.A.27.12
A systematic screen of memory B-cell expansion conditions for use in antigen specific ELISpot assays to help understand effective vs ineffective vaccine responses
P.A.27.13
Boost of allergen-peptide-specific secondary antibody responses by oligomeric peptide without allergen-specific T cell help
P.A.27.14
The adjuvant LT-K63 enhances survival of neonatal B-cells, plasmablasts/plasma cells by increasing their expression of BAFFR and BCMA, respectively
P.A.27.15
Adjuvants can increase cell types in bone marrow of neonatal mice that produce survival signals critical for antibody secreting cells
S. Nivine, T. Aurélien, C. Guillaume, S. Christophe, P. Sophie, C. Michel, D. Laurent;
University of Limoges, CNRS UMR 7276, Limoges, France.
L. Muir, P. F. McKay, R. Shattock;
M. Narayanan, M. Focke-Tejkl, R. Valenta, B. Linhart;
S. P. Bjarnarson1,2, A. A. Aradottir Pind1,2, G. Del Giudice3, I. Jonsdottir1,2,4;
1
Landspitali, the National University Hospital of Iceland, Department of Immunology, Reykjavik, Iceland, 2University of Iceland, Faculty of Medicine, Reykjavik, Iceland, 3Novartis Vaccines (a GSK company),
Siena, Italy, 4deCODE genetics, Reykjavik, Iceland.
A. A. Aradottir Pind1,2, S. P. Bjarnarson1,2, G. Del Giudice3, I. Jonsdottir1,2,4;
1
Department of immunology Landspitali University Hospital, Reykjavík, Iceland, 2University of Iceland, Reykjavík, Iceland, 3Novartis Vaccines (a GSK company), Siena, Italy, 4deCODE Genetics, Reykjavík,
Iceland.
Chairpersons: Thomas Brocker; Vienna, Austria / Johannes Stöckl; Vienna, Austria
P.A.28.01 A Role for PRMT5 in memory T cell responses
M. Guerau, K. Jablonski, L. Webb, H. Savardekar, S. Amici, A. Panfil, K. Thornton, L. Li, P. Green, C. Li, R. Baiocchi;
The Ohio State University, Columbus, OH, United States.
89
P.A.28.03
T cell death and proliferative responses regulated by cFLIP
J. Zhang, L. Qian, C. Curcione, A. Glibicky;
Thomas Jefferson University, Philadelphia, PA, United States.
P.A.28.04 Induced IL-7 and IL-15 proliferation of CD4+31+ and CD8+31+ cells in vitro
E. A. Blinova, E. A. Pashkina, V. A. Kozlov;
Research Institute of Clinical Immunology, Novosibirsk, Russian Federation.
P.A.28.05 Aurora A is required for early signaling and vesicle dynamics during T cell activation
N. Blas-Rus1, E. Bustos-Morán2, I. Pérez de Castro3, G. De Cárcer3, M. Malumbres3, N. Martín-Cófreces2, F. Sánchez-Madrid1;
1
Hospital Universitario de la Princesa, Madrid, Spain, 2Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain, 3Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.
P.A.28.06 Two-faced MAP4: Dual role on the regulation of early and late T cell activation
E. Bustos-Morán1, N. Blas-Rus2, N. Martín-Cófreces1, F. Sánchez-Madrid2,1;
1
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain, 2Hospital Universitario de la Princesa, Madrid, Spain.
P.A.28.08 Mathematical modelling of CD8+ T cell activation during skin sensitisation
N. Gellatly, R. Cubberley, S. Dhadra, C. Mackay, R. Pendlington, J. Pickles, J. Reynolds, O. Saib, D. Sheffield, R. Stark, D. Tang, G. Maxwell;
Unilever, Sharnbrook, United Kingdom.
P.A.28.09 The Y571 residue of ADAP is required for CXCR4-mediated F-actin reorganisation and T-cell migration
S. Kliche1, N. Waldt1, A. Witte1, B. Kuropka2, C. Freund3, B. Schraven1;
Institute of Molecular and Clinical Immunology, Magdeburg, Germany, 2Leibniz-Institute for Molecular Pharmacology, Berlin, Germany, 3Institute for Chemistry and Biochemistry, Berlin, Germany.
1
P.A.28.10 Cell-autonomous expression of the insulin receptor is critical for full activation of CD4+ and CD8+ T cells in vivo
H. J. Fischer, E. Schumann, H. M. Reichardt;
Institute for Cellular and Molecular Immunology, Göttingen, Germany.
P.A.28.11 T cells kill bacteria captured by transinfection from dendritic cells and confer protection in mice
A. Cruz Adalia1,2, G. Ramirez Santiago3, C. Calabia-Linares21, M. Torres-Torresano1, L. Feo1, M. Galán-Díez4, E. Fernandez-Ruiz4, G. Martínez del Hoyo5, F. Sánchez Madrid1,4, E. Veiga1,2;
1
Centro Nacional de Biotecnología (CNB/ CSIC), Madrid, Spain, 2Hospital Santa Cristina (Instituto de Investigación Sanitaria Princesa), Madrid, Spain, 3CNB/CSIC, Madrid, Spain, 4Instituto de Investigación
Sanitaria Princesa, at Hospital de la Princesa, Madrid, Spain, 5Centro Nacional de Investigaciones Cardiovasculares, CNIC, Madrid, Spain.
P.A.28.12 Role of the transcriptional repressor IRF2BP2 on CD4 T cell activation
C. Secca da Silva1, S. Hanschke1, P. Araújo Souza2, D. V. Faget1, J. P. Viola1;
1
Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil, 2Fluminense Federal University (UFF), Niteroi, Brazil.
P.A.28.13
Elucidation of transcription factor profiles in HIV-specific CD4+ T cells using single-cell multiplex RT-PCR
C. Phetsouphanh1, Y. Xu1, M. Bailey1, N. Seddiki2, J. J. Zaunders1,3, A. D. Kelleher1,3;
1
The Kirby Insitute, University of New South Wales, Kensington, Australia, 2INSERM U955 équipe 16, Institut Mondor de Recherche Biomédicale, Créteil, France, 3St Vincent’s centre of applied medical
research, Darlinghurst, Australia.
Wednesday
P.A.28.14 The role of the immunomodulatory receptor CD160 in a model of experimental malaria infection
F. Muscate, T. Jacobs;
Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany.
P.A.28.15
Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: simultaneous measurement of NF-κB, NFAT and AP-1
S. Jutz1, J. Leitner1, K. Schmetterer2, K. Grabmeier-Pfisterhammer3, P. Steinberger1;
1
Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2) Department of Laboratory Medicine, Medical University of Vienna,
Vienna, Austria, 3Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria.
P.A.28.16 Intracellular dynamics of phosphatase of regenerating liver 1 in T lymphocytes
P. Castro Sánchez*1, R. Ramírez-Muñoz*1, J. Muñoz2, P. Roda-Navarro1;
1
Faculty of Medicine. UCM, Madrid, Spain, 2Center of Cytometry and Fluorescence Microscopy. UCM, Madrid, Spain.
P.A.28.17
Golgi-microtubule associated protein (GMAP-210) is involved in the trafficking of vesicles-containing linker for activation of T-cell (LAT) during T cell activation
A. Zucchetti, J. Carpier, S. Dogniaux, L. Bataille, C. Hivroz;
Institut Curie, Centre de Recherche, Pavillon Pasteur, INSERM, Unité 932, Immunité et Cancer, Paris, France.
P.A.28.18 CD5-mediated inhibition of T cell activation: a detailed analysis of CD5 extracellular and intracellular interactions
R. F. Santos1,2, A. M. Santos3, L. Oliveira1,2, J. Huo3, S. J. Davis3, A. M. Carmo1,2,4;
1
IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal, 2Cell Activation and Gene Expression Group, Instituto de Investigação e Inovação em Saúde, Porto, Portugal, 3Weatherall Institute of
Molecular Medicine, University of Oxford, Oxford, United Kingdom, 4ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
P.A.28.19 A cholesterol-based allostery model of T cell receptor phosphorylation
M. Swamy1,2, K. Beck-Garcia1,3,4, E. Beck-Garcia1,5,6, F. A. Hartl1,4, S. Yousefi1,4,3, A. Morath1,4,3, E. Molnár1, A. K. Schulze7, B. Alarcon8, T. Höfer7, S. Minguet1,4,9, W. W. Schamel1,4,9;
1
Universtity of Freiburg, Freiburg, Germany, 2College of Life Sciences, Dundee, United Kingdom, 3Spemann Graduate School of Biology and Medicine (SGBM), Freiburg, Germany, 4BIOSS Centre for
Biological Signalling Studies, Freiburg, Germany, 5International Max Planck-Research School for Molecular and Cellular Biology (IMPRSMCB), Freiburg, Germany, 6Max Planck- Institute of Immunobiology
and Epigenetics, Freiburg, Germany, 7German Cancer Research Center (DKFZ), Heidelberg, Germany, 8Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain, 9Centre for Chronic
Immunodeficiency CCI, Freiburg, Germany.
P.A.28.20 Natural killer T cells: Potential role in immunometabolism of morbid obesity
S. Lopez1,2, S. Garcia-Serrano3, C. Gutierrez-Repiso3, J. Garcia-Arnes4, A. Rodriguez-Cañete4, F. J. Moreno-Ruiz4, E. Garcia-Fuentes3, D. Pozo1,2;
1
CABIMER-Andalusian Center for Molecular Biology and Regenerative Medicine (CSIC-University of Seville-UPO-Junta de Andalucia), Seville, Spain, 2Department of Medical Biochemistry, Molecular
Biology and Immunology, The University of Seville Medical School, Seville, Spain, 3Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital
Regional Universitario, Malaga, Spain, 4Unidad de Gestión Clínica de Cirugía General, Digestiva y Trasplantes, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario,
Malaga, Spain.
P.A.28.22
P2X7 receptor signaling pathways and expression are dissociated in conventional T cells according to their state of activation, but not in Foxp3+ regulatory T cells
A. Mellouk, H. Safya, P. Bobé;
Université Paris Sud and INSERMU1174, Orsay, France.
Chairpersons: Lucio R. Castellano; João Pessoa Paraíba, Brazil / Kjell-Olov Grönvik; Uppsala, Sweden
P.B.29.01
Lcn2 dampens anti-viral immune responses and restores tissue homeostasis
P.B.29.02
Relevance of Mincle during infection with Vaccinia virus
P.B.29.03
Analysis of the cellular immune response to Nipah virus-like particles in mice and pigs
B. Drobits1,2, K. Lakovits2, S. Knapp1,2;
1
Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria, 2Medical University of Vienna, Department of Medicine I, Infection Biology Lab, Vienna, Austria.
F. J. Cueto, S. Iborra, D. Sancho;
Spanish National Center for Cardiovascular Research, Madrid, Spain.
E. Stroh, S. Diederich, M. H. Groschup;
Institute for Novel and Emerging Infectious Diseases, Friedrich-Loeffler Institute, Greifswald - Island Riems, Germany.
P.B.29.04 Microarray-based profiling of human rhinovirus-specific antibody responses
K. Niespodziana1, C. R. Cabauatan1, C. Lupinek1, D. Ebner2, T. Schlederer2, C. Harwanegg2, K. Stenberg-Hamar3, C. Söderhäll4, J. R. Konradsen3,5, E. Melén6,7, M. van Hage8, G. Hedlin3,5, R. Valenta1;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Phadia
Austria GmbH, Part of Thermo Fisher Scientific ImmunoDiagnostics, Vienna, Austria, 3Astrid Lindgren Children´s Hospital, Karolinska University Hospital, Stockholm, Sweden, 4Department of Biosciences
and Nutrition, and Center for Innovative Medicine (CIMED), Karolinska Institutet, Stockholm, Sweden, 5Department of Women´s and Children´s Health, Karolinska Institutet, Stockholm, Sweden, 6Institute
of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 7SachsĆhildren´s Hospital, Södersjukhuset, Stockholm, Sweden, 8Clinical Immunology and Allergy Unit, Department of Medicine,
Solna, Karolinska Institutet and University Hospital, Stockholm, Sweden.
90
P.B.29.05
Anti-ribosomal P protein antibody outside SLE
M. Castaño Pinardo1, M. Tellez2, M. Núñez-Beltrán1, A. Comins-Boo1, G. Candelas3, J. Jover3, S. Sánchez-Ramón1;
Department of clinical immunology, Hospital Clinico San Carlos, Madrid, Spain, 2Department of internal medicine, Hospital Clínico San Carlos, Madrid, Spain, 3Department of rheumatology, Hospital Clínico
San Carlos, Madrid, Spain.
1
P.B.29.06 The presence of Japanese encephalitis antibodies and the risk of hospitalization due to dengue infection
K. C. Jeewandara1,2, L. Gomez1, S. A. Paranavitane1, M. Tantirimudalige1, S. Panapitiya1, A. Jayewardane2, S. Fernando1, R. H. Fernando1, S. Prathapan1, G. S. Ogg3,4, G. N. Malavige1,3;
1
Centre for Dengue Research, Faculty of Medical Sciences,University of Sri Jayawardanapura, Nugegoda, Sri Lanka, 2Department of Family Medicine, Faculty of Medical Sciences,University of Sri
Jayawardanapura, Nugegoda, Sri Lanka, 3MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine,NIHR Biomedical Research Centre and University of Oxford, Oxford, United Kingdom,
4
Department of Dermatology, Churchill Hospital,, Oxford, OX3 7LJ, United Kingdom.
P.B.29.07
Factors related to the development of CMV-specific CD8+ T-cell response in CMV-seropositive solid organ transplant candidates
S. Cantisán1,2, C. Rodelo-Hadd3, A. Páez-Vega1,2, A. Nieto4, J. M. Vaquero5,2, A. Poyato6, M. Montejo7,2, M. C. Fariñas8,2, A. Rivero1,9, R. Solana1,10,2, A. Martin-Malo3, J. Torre-Cisneros1,9,2;
1
IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015), Instituto de Salud Carlos III, Madrid, Spain, 3Department
of Nephrology, Reina Sofia Hospital, Cordoba, Spain, 4Deparment of Immunology, Puerta del Mar Hospital, Cadiz, Spain, 5Department of Neumology, Reina Sofia Hospital, Cordoba, Spain, 6Department
of Hepatology, Reina Sofia Hospital, Cordoba, Spain, 7Infectious Diseases Unit, Cruces Hospital, Bilbao, Spain, 8Infectious Diseases Unit, Marqués de Valdecilla Hospital, University of Cantabria, IDIVAL,
Santander, Spain, 9Infectious Diseases Unit, Reina Sofia Hospital, Cordoba, Spain, 10Department of Immunology, Reina Sofia Hospital, Cordoba, Spain.
P.B.29.08 Soluble human leukocyte antigen E in chronic HBV infection
I. Zidi1, A. Laaribi1,2, D. Bortolotti3, N. Hannachi2, H. Ben Yahia1, A. Mehri2, H. Chaouch4, N. Zidi5, A. Letaif4, S. Yacoub6, A. Boudabous1, J. Boukadida2, R. Rizzo3;
1
Laboratory Microorganismes et Biomolécules Actives, Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia, 2Laboratory of Microbiology-Immunology, UR02SP13, University Hospital
Farhat Hached, Sousse, Tunisia, 3Department of Experimental and Diagnostic Medicine, Section Microbiology, University of Ferrara, Ferrara, Italy, 4Department of Internal Medicine and Infectious Diseases,
University Hospital Farhat Hached, Sousse, Tunisia, 5Faculty of Medicine Ibn Al Jazzar, Sousse, Tunisia, 6Regional Center of Blood Transfusion, University Hospital Farhat Hached, Sousse, Tunisia.
P.B.29.09 Increase of soluble Human leukocyte antigen-G in patients with chronic hepatitis B infection
A. Laaribi1,2, R. Rizzo3, D. Bortolotti3, N. Hannachi2, H. Ben Yahia1, A. Mehri2, H. Chaouch4, N. Zidi5, A. Letaif4, S. Yacoub6, A. Boudabous1, J. Boukadida2, I. Zidi1;
1
Laboratory Microorganismes et Biomolécules Actives, Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia, 2Laboratory of Microbiology-Immunology, UR02SP13, University Hospital
Farhat Hached, Sousse, Tunisia, 3Department of Experimental and Diagnostic Medicine, Section Microbiology, University of Ferrara, Ferrara, Italy, 4Department of Internal Medicine and Infectious Diseases,
University Hospital Farhat Hached, Sousse, Tunisia, 5Faculty of Medicine Ibn Al Jazzar, Sousse, Tunisia, 6Regional Center of Blood Transfusion, University Hospital Farhat Hached, Sousse, Tunisia.
P.B.29.10
Solute Carriers: Proteins at the Interface of Host Metabolism and Viral Life Cycle
P.B.29.11
Neutral sphingomyelinase in physiological and measles virus induced T cell suppression
P.B.29.12
Ex vivo analysis of herpes simplex virus type 2 (HSV-2) reactive T cells derived from the human female genital tract
P.B.29.13
Respiratory Syncytial Virus targets a regulatory B cell population early in life
A. Moskovskich, C. Trefzer, E. Girardi, B. Snijder, R. K. Kandasamy, G. Superti-Furga;
CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
C. M. Posavad1,2, L. Zhao1, L. Dong1, C. E. Stevens1, D. M. Koelle1,2, A. S. Magaret1,2, A. Wald1,2, L. Corey1,2;
1
University of Washington, Seattle, WA, United States, 2Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
D. Zhivaki1, X. Zhang2, M. Rameix-Welti3, A. LIm1, D. Descamps4, S. Riffault4, J. Eléouët4, P. Tissières5, C. Leclerc1, R. Lo-Man1;
Institut Pasteur, PARIS, France, 2Institut Pasteur of Shanghai, Shanghai, China, 3APHP, Hôpital Ambroise Paré, Boulogne-Billancourt, France, 4INRA, unité Virologie et Immunologie Moléculaires, Jouy en
Josas, France, 5APHP, Hôpital Bicêtre, Kremlin Bicetre, France.
1
P.B.29.15
Detection of p16 and Ki67 cell transformation markers in urogenital papilloma virus infections
L. V. Solomatina1,2, Y. N. Kuznetsova3, N. P. Evstigneeva3, N. V. Zilberberg3, N. A. Gerasimova3, N. A. Balbert3;
1
Ural Federal University Named After the First President of Russia B. N. Yeltsin, Ekaterinburg, Russian Federation, 2Institute of Immunology and Physiology, Ural Branch of the RAS, Ekaterinburg, Russian
Federation, 3Federal state institution “Ural scientific research Institute of dermatovenerology and immunopathology” of the Ministry of health of the Russian Federation, Ekaterinburg, Russian Federation.
P.B.29.16 Expression of HAdV Immunogenic Epitope Chimeric Protein and Application for Detection of Antibodies against HAdV
X. Wang1,2, Y. Qi1, T. Xu1,3, Y. Pan1, S. Li1, J. Li1, S. Li1,3, C. Chen1,2, Y. Xu1,2, Y. Li1;
1
Huadong Research Institute for Medicine and Biotechniques,Nanjing 210002, China, Nanjing, China, 2School of Life Science and Technology,China Pharmaceutical University,Nanjing 210009,China,
Nanjing, China, 3School of Basic Medicine, Nanjing Medical University, Nanjing 210005, China, Nanjing, China.
P.B.29.17
Wednesday
N. Müller, E. Avota, L. Collenburg, S. Schneider-Schaulies;
University Wuerzburg, Würzburg, Germany.
In-silico analysis of Chikungunya viral proteome: Implications for autoimmunity through molecular mimicry
V. Janakiraman, V. Srivatsava;
IIT-M, Chennai, India.
P.B.29.18 Correlation of pro-inflammatory mediators in patients with HTLV-1
H. V. Neco1, V. G. Teixeira2, A. C. Trindade2, P. M. Magalhães2, V. M. Lorena3, V. M. Silva4, P. A. Fernandes4, J. R. Souza4, L. R. Castellano4, C. W. Pissetti5,4, P. M. Moura2, C. N. Morais1;
1
Departament of Virology, Centro de Pesquisas Aggeu Magalhães (CPqAM), Oswaldo Cruz Foundation (Fiocruz), Recife PE, Brazil, 2Laboratory of Virus Molecular Biology, Pernambuco University (UPE),
Recife PE, Brazil, 3Departament of Immunology, Centro de Pesquisas Aggeu Magalhães (CPqAM), Oswaldo Cruz Foundation (Fiocruz), Recife PE, Brazil, 4Human Immunology Research and Education
Group, Escola Técnica de Saúde da UFPB, Universidade Federal da Paraíba, João Pessoa PB, Brazil, 5Programa de Pós-Graduação em Atenção à Saúde, Universidade Federal do Triângulo Mineiro, Uberaba,
Brazil.
Chairpersons: Elisabeth Förster-Waldl; Vienna, Austria / Hermann Wolf; Vienna, Austria
P.B.30.01
CVID patients display an IgG-isotype-specific defect in ABO blood group antibody formation as detected by surface plasmon resonance analysis
P.B.30.02
AIRE is required for recruitment of Dectin-1 and Dectin-2 receptors at macrophage-hyphae interface, and in cytokine mediated regulation of innate immune
response
M. B. Fischer1,2, W. Wolfram1, C. J. Binder3, G. A. Böhmig4, M. Wahrmann4, M. M. Eibl5, H. M. Wolf5;
1
Department of Transfusion Medicine, Medical University of Vienna, Vienna, Austria, 2Center of Biomedical Technology, Danube University Krems, Krems an der Donau, Austria, 3Department of Laboratory
Medicine, Medical University of Vienna, Vienna, Austria, 4Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria, 5Immunologische Tagesklinik,
Vienna, Austria.
J. Tavares de Albuquerque1, P. P. Banerjee2,3, M. W. Barbosa-Carvalho1, C. Arslanian1, F. G. Weiler4, M. Lazaretti4, L. A. Pedroza5, J. Orange2,3, A. Condino-Neto1;
1
Biomedical Science Institute, Sao Paulo, Brazil, 2Center for Human Immunobiology, Texas Children’s Hospital, Houston, TX, United States, 3Baylor College of Medicine, Houston, TX, United States, 4Federal
University of Sao Paulo, Sao Paulo, Brazil, 5Universidad San Francisco de Quito, Quito, Ecuador.
P.B.30.03
Investigation of alpha-Gal natural antibodies in all IgG, IgA, IgM and IgE isotypes
P.B.30.04
The quantity of naive T-helper cells with patients having primary antibody deficiencies
P.B.30.05
IgG scintigraphy is helpful to diagnose an asymptomatic inflammatory bowel condition in antibody deficiencies and low IgG trough levels despite high doses of Ig
replacement
V. Thon1, M. Hamanova1, S. Pesak1, M. Vesela2, Z. Chovancova1, J. Litzman1, J. Lokaj1;
1
Department of Clinical Immunology and Allergy, Faculty of Medicine, Masaryk University and St. Anne´s University Hospital, Brno, Czech Republic, 2First Department of Pathological Anatomy, St. Anne´s
University Hospital, Brno, Czech Republic.
M. Karakina, P. Irina;
Institute Immunology and Phisiology, Ekaterinburg, Russian Federation.
C. Milito, F. Pulvirenti, V. Megna, M. Liberatore, I. Quinti;
“Sapienza” University of Rome, Rome, Italy.
P.B.30.06
A possible type II Bare lymphocyte syndrome: a case report
P.B.30.07
A nonsense CD33 mutation is associated with lack of CD33 surface expression and myeloid cell dysregulation
G. Salgado-Cecilia1, J. Eguía-Núñez1, E. M. Novoa-Bolívar1, M. R. Moya-Quiles1, S. Alfayate-Miguélez2, A. I. Menasalvas-Ruíz2, A. Bernal-Ramos1, H. Martínez-Banaclocha1, M. V. Martínez-Sánchez1, M.
Muro-Amador1, A. Minguela-Puras1, A. M. García-Alonso1;
1
Immunology Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, 2Pediatric Infectious Disease Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
C. B. Geier, K. M. Sauerwein, D. Bra, A. Linder, A. Piller, M. M. Eibl, H. M. Wolf;
Immunology Outpatient Clinic, Vienna, Austria.
91
P.B.30.08
DHR assay in brazilian patients with Chronic Granulomatous Disease: What is the limit?
P.B.30.09
Clinical, immunological and cytogenetic findings in children with Nijmegen breakage syndrome and ataxia-telangiectasia from Latvia
P.B.30.10
Chronic granulomatous disease and McLeod neuroacanthocytosis syndrome: a contiguous gene syndrome
P.B.30.11
Characteristics and complications of the patients with common variable immune deficiency
P.B.30.12
Idiopathic Thrombocytopenic purpura and poly-adenopathic syndrome, secondary to Common Variable Immunodeficiency
P.B.30.13
Identification of novel mutations in Common Variable Immunodeficiency Syndrome (CVID) through targeted re-sequencing of a CVID cohort
P.B.30.14
Serum protein electrophoresis allows the detection of a case of complement factor I (CFI) deficiency in an adult patient due to a novel homozygous mutation
N. B. Zurro, E. B. de Oliveira, A. Condino-Neto;
A. Dzalbs, T. Prokofjeva, I. Grinfelde, L. Kornejeva, Z. Krumina;
Children’s Clinical University Hospital, Riga, Latvia.
J. Eguía-Núñez1, G. Salgado-Cecilia1, E. M. Novoa-Bolívar1, M. R. Moya-Quiles1, S. Alfayate-Miguélez2, A. I. Menasalvas-Ruíz2, C. Funes-Vera3, A. Bernal-Ramos1, M. Muro-Amador1, A. Minguela-Puras1, A.
M. García-Alonso1;
1
Immunology Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, 2Pediatric Infectious Disease Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain,
3
Hematology Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
N. Gulez, S. Bahceci, F. Genel, S. Karaman, H. Nacaroglu, S. Karkıner;
Dr. Behcet Uz Children Hospital, Izmir, Turkey.
E. Novoa-Bolívar, J. Galian-Megias, J. Eguia-Nuñez, G. Salgado-Cecilia, A. Minguela-Puras, R. Moya-Quiles, A. Garcia-Alonso;
Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
F. Atschekzei1, C. Schröder1, T. Witte1, B. Grimbacher2, R. Schmidt1;
1
MHH, Department for Clinical Immunology and Rheumatology, Hannover, Germany, 2Center for Chronic Immunodeficiency, Freiburg University Medical Center, Hannover, Germany.
C. Franco-Jarava1,2, M. Martínez-Gallo1,2, R. Colobran1,2, J. Mestre-Torres3, E. Garcia-Guantes1, R. Pujol-Borrell1,2, M. Hernandez-Gonzalez1,2;
Immunology Division, Hospital Universitari Vall d’Hebron (HUVH), Vall d’Hebron Research Institute (VHIR)., Barcelona, Spain, 2Department of Cell Biology, Physiology and Immunology, Universitat
Autònoma de Barcelona. Spain, Bellaterra, Barcelona, Spain, 3Internal Medicine Department, Hospital Universitari Vall d’Hebron (HUVH), Barcelona, Spain.
1
Wednesday
P.B.30.15
CD117 (cKit)+ Innate lymphoid cells are reduced in patients with common variable immunodeficiency
P.B.30.16
NFκB1 mutations in common variable immunodeficiency
P.B.30.17
Defective specific antibody response in common variable immunodeficiency
C. B. Geier, D. Bra, M. M. Eibl, H. M. Wolf;
Immunologische Tagesklinik, Wien, Austria.
M. Fliegauf1, V. Bryant2,3, N. Frede1, C. Slade2,3,4, S. Woon5, K. Lehnert6, S. Winzer1, A. Bulashevska1, T. Scerri2,3, E. Leung6, A. Jordan5, B. Keller1, E. de Vries7, H. Baxendale8, H. Cao9, F. Yang9, A. A. Schäffer10,
K. Warnatz1, P. Browett6, J. Douglass4,3, R. V. Ameratunga5, J. W. van der Meer11, B. Grimbacher1,12;
1
Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany, 2The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia,
3
University of Melbourne, Melbourne, Australia, 4Royal Melbourne Hospital, Melbourne, Australia, 5Auckland City Hospital, Auckland, New Zealand, 6University of Auckland, Auckland, New Zealand, 7Jeroen
Bosch Hospital, ‘s-Hertogenbosch, Netherlands, 8Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom, 9Bejing Genomics Institute, Shenzhen, China, 10NCBI, NIH, Department of Health
and Human Services, Bethesda, MD, United States, 11Radboud University Medical Centre, Nijmegen, Netherlands, 12University College, London, United Kingdom.
N. Kechout1, N. Abdellaoui1, F. Doudou1, M. Abbadi1, R. Boukari2, N. Attal1;
Institut Pasteur d’Algérie, Algiers, Algeria, 2CHU Mustapha Pacha, Algiers, Algeria.
1
P.B.30.18
Clinical, immunological and genetic features of Algerian patients with leukocyte adhesion deficiency type I
P.B.30.19
Evaluation of patients with Down Syndome in pediatric immunology practice
P.B.30.20
Diverse clinical phenotypes in recombinase-activating gene 1 deficiency: a single-center experience
P.B.30.22
Identifying new definitions of humoral immunity risk for development of recurrent community acquired pneumonia
P.B.30.23
Long-term survival after echovirus meningoencephalitis in a XLA patient: Sequential combined therapy with high dose intravenous immunoglobulin, pleconaril
and intrathecal immunoglobulin
N. Kechout1, N. Benmesbah1, N. Touri2, C. kaddache2, F. Doudou1, M. Abbadi1, R. Boukari3, N. Attal1;
1
Institut Pasteur d’Algérie, Algiers, Algeria, 2CHU Blida, Algiers, Algeria, 3CHU Mustapha Pacha, Algiers, Algeria.
N. Gulez, F. Hazan, E. Durgun, F. Genel, P. Gulez;
Dr. Behcet Uz Children Hospital, Izmir, Turkey.
E. Ulusoy, N. E. Karaca, G. Aksu, E. Azarsiz, N. Kutukculer;
Ege University Medical School, Department of Pediatric Immunology, Izmir, Turkey.
J. Carbone, E. Sarmiento, M. Arraya, J. Navarro, J. Rodriguez-Molina, A. Polo, E. Donis, E. Fernandez-Cruz;
J. Carbone1, D. Hipola2, S. Sanchez-Ramon1, E. Sarmiento1, F. de Ory3, J. Rodriguez-Molina1, S. Sanchez-Alarcos4, E. Fernandez-Cruz1;
Hospital General Universitario Gregorio Marañon. Immunology Department., Madrid, Spain, 2Hospital Universitario Infanta Leonor. Neurology Department., Madrid, Spain, 3Centro Nacional de
Microbiología, Instituto de Salud Carlos III. Serology Department, Madrid, Spain, 4Hospital General Universitario Gregorio Marañon. Neurosurgery Department., Madrid, Spain.
1
P.B.30.24
The Effect of Resistance Training on HSP 70 and Glucose
1
Varamin Pishva Branch, Islamic Azad University, Varamin, Pishva, Iran, Islamic Republic of, 2Financial Management, Tehran, Iran, Islamic Republic of.
P.B.31 Secondary Immunodeficiencies
Chairpersons: Doris Wilflingseder; Innsbruck, Austria / Nabila Seddiki; Creteil, France (tbc)
P.B.31.01
A91V mutation in perforin PRF1-gene in patient with hemophagocytic lymphohistiocytosis, leishmaniasis and chronic lymphocytic leukemia
P.B.31.02
Immunodeficiency in CLL patients: impact of immunoglobulin replacement therapy
P.B.31.03
Local regulation of glucocorticoid action is involved in altered inflammatory response pattern caused by intrauterine undernourishment
P.B.31.04
Adrenalectomy fails to reverse the decreased lung inflammation presented by intrauterine undernourished rats
P.B.31.05
Have the exposure to anti-TNFa-mAbs during 3rd trimester of pregnancy got an impact on immune development in the neonate?
V. Cunill1,2, M. R. Jiménez1,2, A. Molina1,2, J. Sánchez Raga3, J. Iglesias1,2, M. C. Ballester3, M. A. Durán3, N. Martínez-Pomar1,2;
1
Department of Immunology, Hospital Universitari Son Espases, Palma de Mallorca, Spain, 2Institut dÍnvestigació Sanitària de Palma (IdISPa), Palma de Mallorca, Spain, 3Department of Hematology,
Hospital Universitari Son Espases, Palma de Mallorca, Spain.
F. Cinetto, N. Compagno, A. Visentin, L. Trentin, C. Agostini;
University of Padova, Padova, Italy.
A. M. Balbino1, D. B. Vaz1, E. H. Akamine2, M. C. Carvalho2, R. G. Landgraf1, M. A. Landgraf2;
1
Federal University of São Paulo, Diadema, Brazil, 2University of São Paulo, São Paulo, Brazil.
N. L. Gil1, G. A. Azevedo1, M. M. Silva1, L. Fernandes1, M. A. Landgraf1,2, R. G. Landgraf1;
1
Federal University of São Paulo, Diadema, Brazil, 2University of São Paulo, São Paulo, Brazil.
A. Esteve-Sole1,2, N. de Moner2, I. Teixidó3, E. Ricart4,5, E. A. Gonzalez6, A. Deyà1, A. Plaza1, J. Yagüe2, M. Juan2, L. Alsina1;
Allergy and Clinical Immunology Department. Hospital Sant Joan de Déu, Esplugues del Llobregat, Spain, 2Servei d’Immunologia. Centre de Diagnòstic Biomèdic. Hospital Clínic, Barcelona, Spain, 3Casa
Maternitat. Hospital Clínic, Barcelona, Spain, 4Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain, 5Department of Gastroenterology,
Hospital Clínic de Barcelona, IDIBAPS, University of Barcelona,, Barcelona, Spain, 6Servei d’Immunologia. Centre de Diagnòstic Biomèdic CDB. Hospital Clínic, Barcelona, Spain.
1
P.B.31.06
Indoleamine 2,3-Dioxygenase (IDO) is a new player in sepsis-induced immunosuppressoin
P.B.31.07
Comparative studies of different cryopreservation methods for thymus stromal cells derived from human thymus
R. G. Ferreira, D. Nascimento, P. Melo, A. Alvarez, D. Prado, G. Souza, T. Cunha, F. Cunha, J. Alves-Filho;
Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, Brazil.
N. Grabchenko1, N. Korotkevich1, O. Karpachova1, V. Glinka1, V. Sulyma1, I. Aksyonova2,1, B. Todurov2,1, V. Shichkin1;
Research Centre of Immunology and Biomedical Technologies, Open International University of Human Development “Ukraine”, Kyiv, Ukraine, 2Institute of Heart, Ministry of Health of Ukraine, Kyiv,
Ukraine.
1
92
P.B.31.08
Genetic variation in CCR5 correlate with CD4+ T cell recovery in Omani AIDS patients on combined antiretroviral therapy
P.B.31.09
Dendritic cell infection by complement-opsonized HIV is associated with an aberrant type I IFN response
A. A. Al-Jabri, S. H. Al-Mahruqi;
Sultan Qaboos University, Muscat, Oman.
M. Steger1, W. Posch1, U. Knackmuß1, M. Blatzer1, A. Moris2, C. Lass-Flörl1, O. T. Keppler3, D. Wilflingseder1;
Division of Hygiene and Medical Mikrobiology, Innsbruck, Austria, 2INSERM UMRS-945, Infection and Immunity, Paris, France, 3Institute of Medical Virology, Frankfurt, Germany.
1
P.B.31.10
HIV infection impairs bone marrow environment blunting Hematopoietic Progenitor Cells differentiation toward T cells and immune reconstitution
P.B.31.11
Distinct subsets of central memory CD4+ T cells are differential altered by HIV infection: Implications for homeostasis
P.B.31.12
HIV microarray for multiplexed antibody profiling
P.B.31.13
Recognition of multiple PTE Gag peptides variants by HIV-1 Infected Indian Individuals
P.B.31.14
HIV-2+ individuals feature preserved gut homeostasis despite evidence of mucosal viral replication
V. Bordoni, D. Viola, M. Bibas, A. Sacchi, C. Agrati, E. Cimini, R. Casetti, N. Tumino, A. Amendola, F. Martini;
INMI L.Spallanzani, Rome, Italy.
D. Würsch1, D. Romero-Rodríguez1, J. Zúñiga1, S. Pérez-Patrigeon2, G. Olvera-Garcia1, E. Espinosa1;
1
Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Distrito Federal, Mexico, 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Distrito Federal, Mexico.
D. Gallerano1, E. Wollmann1, C. Lupinek1, T. Schlederer2, D. Ebner2, C. Harwanegg2, K. Niespodziana1, K. Schmetterer3, W. Pickl4, E. Puchhammer-Stoeckl5, E. Sibanda6, R. Valenta1;
1
Div. Immunopathology, Inst. of Pathophysiology and Allergy Research, MUW, Vienna, Austria, 2Phadia Austria GmbH, Part of Thermo Fisher Scientific ImmunoDiagnostics, Vienna, Austria, 3Institute of
Laboratory Medicine, MUW, Vienna, Austria, 4Institute of Immunology, MUW, Vienna, Austria, 5Institute of Virology, MUW, Vienna, Austria, 6Asthma, Allergy and Immune Dysfunction Clinic, Parirenyatwa
University Teaching Hospital, Harare, Zimbabwe.
N. Negi, B. Das, M. Vajpayee;
All India Institute of Medical Sciences, New Dlehi, India.
S. M. Fernandes1,2, A. R. Pires1, P. Matoso1, C. Ferreira2, A. E. Sousa1, R. B. Foxall1;
Instituto de Medicina Molecular-Edifico Egas Moniz, Lisbon, Portugal, 2Hospital Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.
1
P.B.31.15
Impact of concomitant HCV infection on the impaired T cell immune response in cART naive HIV+ individuals
P.B.31.16
Complement-opsonized HIV-1 beats SAMHD1 in dendritic cells
P.B.31.17
HIV-infection accentuates phenotype and polyfunctional alterations in monocytes of cART-treated patients independently of age
P.B.31.18
TLR8 regulation of LILRA3 in monocytes is abrogated in human immunodeficiency virus infection and correlates to CD4 counts and virus loads
P.B.31.19
The presence of uncontrolled viral load in HIV-infected patients produces a marked impairment in the number, phenotype and suppressive capacity of Treg cells
P.B.31.20
Potential role of mucosal vaccination against bacterial respiratory infections in patients with immunodeficiency
P.B.31.22
Production of lentiviral particles for the in vivo analysis of sterilizing immunity provided by broadly neutralizing anti-HIV antibodies
M. Alexandrova1, M. Muhtarova1, O. Angelova1, I. Elenkov2, N. Yancheva2, E. Golkocheva-Markova1, M. Nikolova1;
1
National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria, 2Specialized Hospital for Active Treatment of Infectious and Parasitic Diseases “Professor Ivan Kirov”, Sofia, Bulgaria.
W. Posch1, M. Steger1, U. Knackmuss1, M. Blatzer1, A. Moris2, C. Lass-Flörl1, O. T. Keppler3, D. Wilflingseder1;
1
Medical University of Innsbruck, Innsbruck, Austria, 2INSERM, Paris, France, 3University of Frankfurt, Frankfurt, Germany.
H. Low1, G. Ahrenstorf1, P. Claudia2, N. Habermann1, K. Schughart2, D. Ordóñez1, R. Stripecke1, E. Wilk2, T. Witte1;
1
Hannover Medical School, Hannover, Germany, 2Helmholtz Centre for Infection Research, Braunschweig, Germany.
J. Lopez-Abente1, D. Jaramillo-Ruiz2, M. Martinez-Bonet2, M. Leal3, Y. M. Pacheco3, M. Á. Muñoz-Fernández2, M. Pion1,2, R. Correa-Rocha1;
1
Laboratorio de Inmuno-regulación. Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain, 2Laboratorio de Inmunobiología Molecular. Hospital General Universitario Gregorio
Marañón and Insitituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain, 3Laboratorio de Inmunovirología, Hospital Universitario Virgen del Rocío and Instituto de Biomedicina de Sevilla
(IBIS), Sevilla, Spain.
J. Carbone, M. Arraya, E. Sarmiento, E. Fernandez-Cruz;
Hospital General Universitario Gregorio Marañon. Immunology Department, Madrid, Spain.
Wednesday
R. S. de Pablo-Bernal1, J. Cañizares2, M. I. Galvá2, R. Ramos2, S. Ferrando-Martínez3, M. B. Rafii-El-Idrissi1, Y. M. Pacheco1, E. Ruiz-Mateos1, M. Leal1;
1
Biomedicine Institute of Seville, Seville, Spain, 2Heliopolis Nursing Home, Seville, Spain, 3Vaccine Research Center NIAID NIH, Bethesda, MD, United States.
V. Stab1, B. Tippler1, C. Stahl-Hennig2, K. Sure1, M. Storcksdieck genannt Bonsmann3, M. Tenbusch1, K. Überla4;
Ruhr University Bochum, Bochum, Germany, 2German Primate Center, Göttingen, Germany, 3University Duisburg-Essen, Essen, Germany, 4University Erlangen-Nürnberg, Erlangen, Germany.
1
Chairpersons: Nada Pejnovic; Kragujevac, Serbia / Detlef Neumann; Hannover, Germany (tbc)
P.B.32.01
The impact of fibrinogen carbamylation on blood coagulation in inflammatory diseases
P.B.32.02
Effects of chronic fluoride exposure on the CGRP myenteric varicosities of the small intestine
P.B.32.03
Galectin-3 deletion attenuates inflammation and IL-33 dependent fibrosis in mouse model of nonalcoholic steatohepatitis
P.B.32.04
Inhibition of epidermal growth factor receptor tyrosine kinase by erlotinib prevents sclerodermatous graft versus host disease in a mouse model
V. Binder1, C. Scavenius2, E. Spriet3, A. Nyhaug3, A. Hellvard1, B. Bergum1, C. Koro1, P. Mydel1;
1
Department of Clinical Science, University of Bergen, Bergen, Norway, 2Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark, 3Department of Biomedicine, University of
Bergen, Bergen, Norway.
C. S. Melo1, S. R. Souza2, A. D. Heubel1, I. Zignani2, J. P. Martins2, J. N. Zanoni2, M. A. Buzalaf1;
1
University of Sao Paulo, Bauru-SP, Brazil, 2State University of Maringa, Maringa-PR, Brazil.
I. Jeftic, N. Jovicic, J. Pantic, N. Arsenijevic, M. L. Lukic, N. Pejnovic;
Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, Kragujevac, Serbia.
F. Morin1,2, N. Kavian1,2, W. Marut1, C. Chéreau1, O. Cerles1, P. Grange1, B. Weill1,2, C. Nicco1, F. Batteux1,2;
Institut Cochin, Paris, France, 2Laboratoire d’immunologie - Hôpital Cochin, Paris, France.
1
P.B.32.05
Epidemiology of hepatitis B,C and HIV in pregnant women of a secondary care hospital in Greece
P.B.32.06
Increased anti-Hsp72 autoantibodies in bronchoalveolar lavage fluid of idiopathic pulmonary fibrosis patients correlates with better prognosis
P.B.32.07
Profiling Autoantibodies in COPD using Antigen Microarrays
P.B.32.08
Restoration of extracellular bicarbonate of Cystic fibrosis pulmonary epithelium modulates innate immunomodulatory pathways
P.B.32.09
The effect of Ischemia-reperfusion injury on human proximal tubular epithelial cell phenotype
P.B.32.10
The impact of KLF2/RelA imbalance on neutrophil apoptosis of neutrophilic asthma guinea pig model
P.B.32.11
A successful safety trial of an attenuated visceral leishmaniasis vaccine in an endemic area
P.B.32.12
Study on the role of aristolochic acid in the pathogensis of renal inflammation and fibrosis
P. Karapavlidou, A. Hasiou, O. Sotiriou;
Immunology department, general hospital, Kastoria, Greece.
R. Mills, A. Mathur, L. Nicol, W. Wallace, S. Howie, N. Hirani;
Edinburgh University, Edinburgh, United Kingdom.
R. A. Shindi;
Nottingham University, Nottingham, United Kingdom.
R. Basu1, K. McCall1, F. Schwartz1, J. P. Clancy2, D. R. Straley1;
1
Ohio University HCOM, Athens, OH, United States, 2Cincinnati Children’s Hospital, Cincinnati, OH, United States.
R. Kapoor, J. Kirby, N. Sheerin;
Newcastle university, Newcastle Upon Tyne, United Kingdom.
L. Zhu, H. Li, J. Huang, A. Dai, D. Zeng, X. Hong, Y. Zhu, X. Lei;
Hunan Geriatric Hospital, Chang sha city, China.
M. J. Namazi1,2, H. Daneshvar3;
1
Sabzevar university of medical sciences, Sabzevar, Iran, Islamic Republic of, 2University of Glasgow, Glasgow, United Kingdom, 3Kerman university of medical sciences, Kerman, Iran, Islamic Republic of.
H. Y. Huang, B. Lin;
National Taiwan University, Tapei, Taiwan.
93
P.B.32.13
Stromal cells promote metabolic regulation of hepatic inflammation by myeloid-derived suppressor cells
P.B.32.14
Microbiome-mediated immune activation differently shapes the stroma of bowel both in healthy and pathological conditions
P.B.32.15
Peripheral blood monocyte profiles and P2X7 expression in chronic kidney disease and end-stage renal disease
P.B.32.16
Low levels of natural IgM antibodies towards oxidation specific epitopes are associated with human non-alcoholic steatohepatitis
P.B.32.17
Basophils trigger fibroblast activation in cardiac allograft fibrosis development
P.B.32.18
O-GlcNAcylation protein modification regulates osteoclast differentiation
P.B.32.19
Implication of the PSGL-1/Selectins axis in the development of autoimmune rheumatic diseases
P.B.32.20
Decoy chemokine receptor ACKR2 acts to limit alveolar destruction in cigarette smoking-induced COPD in mice
L. J. Pallett1, U. S. Gill2, A. Quaglia3, L. V. Sinclair4, M. Jover-Cobos1, A. Schurich1, K. P. Singh1, N. Thomas1, A. Das1, A. Chen1, G. Fusai1, A. Bertoletti5, D. A. Cantrell4, P. T. Kennedy2, N. A. Davies1, M. Haniffa6,
M. K. Maini1;
1
University College London, London, United Kingdom, 2Bart’s and the London School of Medicine and Dentistry, London, United Kingdom, 3Kings College Hospital, London, United Kingdom, 4University of
Dundee, Dundee, United Kingdom, 5Agency of Science and Technology, Singapore, Singapore, 6Newcastle University, Newcastle, United Kingdom.
F. Caja1, J. Krizan1, D. Stakheev1, L. Rajsiglova1, J. Dvorak1, O. Chernyavskiy2, R. Stepankova3, H. Kozakova3, T. Hudcovic3, P. Makovicky4, P. Rossmann1, L. Vannucci1;
1
Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic, 2Institute of Physiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic,
3
Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Novy Hradek, Czech Republic, 4Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech
Republic.
S. Naicker1, S. Logue1, D. Cotter2, G. O’Malley1, S. Hanley3, V. Tormey2, R. Ceredig1, M. D. Griffin1,4;
1
Regenerative Medicine Institute, National University of Ireland, Galway, Ireland, 2Immunology Services, Saolta University Hospital Group, Galway, Ireland, 3Flow Cytometry Core Facility, National
University of Ireland, Galway, Ireland, 4Nephrology Services, Saolta University Hospital Group, Galway, Ireland.
T. Hendrikx1,2,3, M. Watzenboeck2,3, S. M. Walenbergh1, S. Amir2,3, S. Gruber2,3, M. Ozsvar-Kozma2,3, S. Kalhan4, G. H. Koek1, D. Jonkers1, C. J. Binder2,3, R. Shiri-Sverdlov1;
1
Maastricht University, Maastricht, Netherlands, 2Medical University Vienna, Vienna, Austria, 3Center for Molecular Medicine (CeMM), Vienna, Austria, 4Lerner Research Institute, Cleveland, OH, United
States.
G. Schiechl1, F. J. Hermann1, M. Rodriguez Gomez1, S. Kutzi1, K. Schmidbauer1, S. Neumayer1, Y. Talke1, N. Goebel1, H. Bruehl1, H. Karasuyama2, K. Obata-Ninomiya2, E. K. Geissler3, S. Fichtner-Feigl3, M.
Mack1;
1
University Hospital Regensburg / Internal Medicine II - Nephrology, Regensburg, Germany, 2Tokyo Medical and Dental University Graduate School, Tokyo, Japan, 3University Hospital Regensburg / Surgery,
Regensburg, Germany.
E. S. Ramos-Junior1, P. H. Melo2, P. A. Pereira2, C. C. Carmo-Silva3, F. Q. Cunha2, J. C. Alves-Filho2, S. Y. Fukada1;
1
School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil, 2Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil, 3Centro Universitário
Barão de Mauá, Ribeirão Preto, Brazil.
J. Silván, A. Pérez-Frías, R. González-Tajuelo, E. Vicente, S. Castañeda, C. Gamallo, A. Urzainqui;
Hospital Universitario La Princesa, Madrid, Spain.
T. T. Ferreira1, D. S. Coutinho1, A. S. Arantes1, B. T. Ciambarella1, M. F. Serra1, A. J. Fernandes1, A. J. Fernandes1, A. G. Silva1, P. M. Silva1, M. Locati2, M. Martins1;
Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, 2Humanitas Clinical and Research Center University, MIlan, Italy.
1
Wednesday
P.B.32.21
Roles of proinflammatory/profibrotic cytokines in the process of PEX production
P.B.32.22
Investigation the role of serum level of Haptoglobulin (HP) in patients suffered from chronic obstructive pulmonary disease (COPD)
P.B.32.23
Mast cell distribution in painful bladder syndrome/interstitial cystitis
P.B.32.24
Cytokine polymorphisms association with fibromyalgia syndrome
N. S. Zdravkovic, S. M. Pavlovic, T. Sarenac Vulovic;
Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
H. Khazaei1, N. A. Moulaei2, F. Jamalzehi3;
1
Department of Medical Immunology, Clinical Immunology Research Center at Zahedan University of Medical Sciences, Zahedan, Iran, Islamic Republic of, 2Department of Internal Medicine, Research
Centre for Tropical, Zahedan, Iran, Islamic Republic of, 3Infectious Diseases of Zahedan University of Medical Sciences, Zahedan, Iran, Islamic Republic of.
S. T. Malik, D. Voegeli, B. Lwaleed;
University of Southampton, Southampton, United Kingdom.
L. Gimeno1, G. Salgado1, E. Novoa1, A. Mrowiec1, I. Legaz2, J. Bolarin1, P. Martinez1, S. Soriano-Diaz1, A. Bernal1, A. Bermudez-Torrente3, A. Martinez-Leon4, I. Ibernon-Caballero5, M. Muro1, M. MoyaQuiles1, J. Campillo1, A. Minguela1, M. Alvarez-Lopez1, I. Lozano5, A. Garcia-Alonso1;
1
Immunology Service-University Clinical Hospital Virgen de la Arrixaca-IMIB, El Palmar-Murcia, Spain, 2Department of Social and Health Sciences; Area of Legal and Forensic Medicine, University of Murcia,
Murcia, Spain, 3Rheumatology Service-University Clinical Hospital Virgen de la Arrixaca-IMIB, El Palmar, Spain, 4Medical Family Health San Andres-Murcia, El Palmar, Spain, 5Psychiatry Service-University
Clinical Hospital Virgen de la Arrixaca-IMIB. Murcia, El Palmar, Spain.
P.B.33 Enviromental and Genetic Factors in Autoimmunity
Chairpersons: Karin Loser; Münster, Germany / Maria Bucova; Bratislava, Slovakia (tbc)
94
P.B.33.01
Possible roles of Klebsiella pneumoniae in the pathogenesis of ankylosing spondylitis
P.B.33.02
Investigation of the role of obesity on the development of Hashimoto’s thyroiditis
P.B.33.03
The enzymatic functions of house dust mites facilitate epithelial barrier impairment
P.B.33.04
Elevated levels of streptococcal antibodies in Finnish children who developed narcolepsy after Pandemrix vaccination
P.B.33.06
Prenatal steroid treatment results in immunological consequences for the offspring
P.B.33.07
Comparison of five different damaging models of the respiratory epithelium
P.B.33.08
Anti-inflammatory effects of vitamin D are maintained under inflammatory cytokine conditions
P.B.33.09
Evaluation of DNMT1 gene expression profile and methylation of its promoter region in patients with Ankylosing Spondylitis
M. Jan1,2, C. Lin1, S. Chuang3, Y. Hsia4,5, Y. Wei6,7, W. Cheng8, J. Wei2,7;
1
Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan, 2Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Chung
Shan Medical University Hospital, Taichung, Taiwan, 3Institute of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan, 4Department of Microbiology and Immunology of
National Cheng Kung University, Tainan, Taiwan, 5Department of Biomedical Science, Chung Shan Medical University, Taichung, Taiwan, 6Department of Microbiology and Immunology, School of Medicine,
Stanford University, Stanford, CA, United States, 7Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, 8Department of Emergency, Tian-Sheng Memorial Hospital, Ping Tong, Taiwan.
A. Gati;
Faculté des Sciences de Tunis, Tunis, Tunisia.
K. Oida1,2, L. Einhorn1,3, I. Herrmann4, S. Vrtala5,6, Y. Resch5, L. Panakova4, G. Hofstetter1, H. Matsuda2, A. Tanaka7, E. Jensen-Jarolim1,3;
1
Comparative Medicine, Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria, 2Laboratory of Veterinary
Molecular Pathology and Therapeutics, Tokyo University of Agriculture and Technology, Tokyo, Japan, 3Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology
and Immunology, Medical University Vienna, Vienna, Austria, 4Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria, 5Division of Immunopathology,
Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University Vienna, Vienna, Austria, 6Christian Doppler Laboratory for the
Development of Allergen Chips, Medical University Vienna, Vienna, Austria, 7Laboratory of Comparative Animal Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan.
M. Melin1, A. Vuorela1, L. Orivuori2, M. Partinen3, P. Saavalainen2, T. Kirjavainen4, P. Olsen5, O. Saarenpää-Heikkilä6, J. Ilonen7, T. Kilpi1, J. Vuopio8, O. Vaarala2;
1
National Institute for Health and Welfare, Helsinki, Finland, 2University of Helsinki, Helsinki, Finland, 3Vitalmed Research Centre Helsinki, Helsinki, Finland, 4Helsinki University Hospital, Helsinki, Finland,
5
Oulu University Hospital, Oulu, Finland, 6Tampere University Hospital, Tampere, Finland, 7University of Turku, Turku, Finland, 8National Institute for Health and Welfare, Turku, Finland.
C. Pekar1, I. Diepenbruck1, C. Remus2, N. Raabe2, E. Tolosa1;
1
Department of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Diagnostic and Interventional Radiology Department, University Medical Center Hamburg-Eppendorf,
Hamburg, Germany.
E. E. Waltl1, R. E. Selb1, J. E. Eckl-Dorna1, R. E. Valenta2, V. E. Niederberger-Leppin1;
1
Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria, 2Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology,
L. E. Jeffery1, K. Raza1,2, D. M. Sansom3;
1
University of Birmingham, Birmingham, United Kingdom, 2Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust,, Birmingham, United Kingdom, 3University College London,
London, United Kingdom.
S. Aslani;
Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
P.B.33.10
Study of programmed cell death 1 (PDCD1) gene polymorphims in Iranian patients with Ankylosing Spondylitis
P.B.33.11
Characteristics of genotypes of ACE gene in obese patients with asthma
P.B.33.12
FoxP3 gene polymorphisms in Behçet’s Disease
P.B.33.13
Association study between CTLA-4 A49G polymorphism in patients with anti-sperm antibody related infertility
P.B.33.14
A combined genome-wide DNA methylation and transcription analysis identified genes related with pathogenesis of systemic sclerosis
P.B.33.15
Lupus-Associated Functional Polymorphism in PNP Causes Cell Cycle Abnormalities in Human Immune Cells
P.B.33.16
Association of single-nucleotide polymorphism (SNP) rs143383 growth and differentiation factor 5 (GDF5) with Knee osteoarthritis
P.B.33.17
Association of STAT4 rs75748665 polymorphism with susceptibility to systemic lupus erythematosus in Algerian population
P.B.33.18
Association of TRAF-1 (rs10818488) and TNFAIP3 (rs2230926) polymorphisms with rheumatoid arthritis and systemic lupus erythematosus and their relationship
to disease activity among Egyptian patients.
N. Soleimanifar1, M. Nicknam2, A. Amirzargar3;
1
Department of Molecular Medicine, Tehran, Iran, Islamic Republic of, 2Molecular Immunology Research Center, Tehran University of Medical Sciences, Iran, Islamic Republic of, 3Department of Immunology,
School of Medicine, Tehran University of Medical Sciences, Iran, Islamic Republic of.
G. Yeryomenko, T. Pasiyeshvili;
Kharkiv National Medical University, Kharkov, Ukraine.
Z. Babaloo1,2,3, A. Hoseini1, E. Sakhinia1,3, A. Khabazi1, D. Shanebandi1;
1
Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of, 2Drug Applied Research Center, Tabriz, Iran, Islamic Republic of, 3Connective Tissue Disorder Research Center, Tabriz, Iran, Islamic
Republic of.
M. Zamani1, N. Rezaei1, A. Salmaninejad2;
1
Department of Immunology & Biology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 2Department of Medical Genetics, School of Medicine, Tehran University
of Medical Sciences, Tehran, Iran, Islamic Republic of.
Q. Li1, H. Zhu1,2, H. Luo1,2, T. Chen1, S. Liu1, M. Yan1, X. Zuo2;
1
University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Xiangya Hospital, Central South University, Changsha, China.
Y. Ghodke-Puranik, J. M. Dorschner, D. M. Vsetecka, S. Amin, A. Makol, F. Ernste, T. Osborn, K. Moder, V. Chowdhary, M. A. Jensen, T. B. Niewold;
M. M. Hassanien;
Asyut University Hospital, Asyut, Egypt.
S. Salah1, H. Iguerguezdaoune1, D. Hakem2, D. Fodil3, M. Djennane4, A. Moussa Mebarek1, A. Djendi1, D. Charron5, A. Ladjouz-Rezig6, S. Lefkir-Tafiani3, R. Tamouza5, N. Attal1;
1
Pasteur Institute of Algeria, Algiers, Algeria, 2Bab El Oued Hospital, Algiers, Algeria, 3Beni Messous Hospital, Algiers, Algeria, 4Tizi Ouzou Hospital, Tizi Ouzou, Algeria, 5Saint Louis Hospital, Paris, France,
6
Ben Aknoun Hospital, Algiers, Algeria.
P.B.33.19
Expression of enterovirus protein in the pancreas, duodenum and spleen of type 1 diabetic (T1D) and prediabetic autoantibody positive (aab+) subjects
P.B.33.20
Comparison of a high salt and a low diet in the murine serum transfer arthritis
P.B.33.21
Association of +190 G/A (rs1799864) polymorphism in the C-C chemokine receptor 2 (CCR2) gene with susceptibility to multiple sclerosis in the Slovak population
M. Oikarinen1, J. E. Laiho1, S. Richardson2, M. Campbell-Thompson3, N. G. Morgan2, A. Pugliese4, S. Tauriainen5, H. Hyöty1;
1
University of Tampere, Tampere, Finland, 2University of Exeter Medical School, Exeter, United Kingdom, 3University of Florida, Gainesville, FL, United States, 4University of Miami, Miami, FL, United States,
5
University of Turku, Turku, Finland.
C. Heuberger1, B. Sehnert1, F. Nimmerjahn2, J. Titze3,4, R. E. Voll1;
1
Department of Rheumatology and Clinical Immunology and Centre of Chronic Immunodeficiency, University Medical Centre and University of Freiburg, Freiburg, Germany, 2Institute of Genetics at the
Department of Biology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, 3Interdisciplinary Center of Clinical Research, Research Group N2, Nikolaus Fiebiger Center of Molecular
Medicine, University of Erlangen-Nürnberg, Erlangen, Germany, 44Department of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, United States.
J. Javor1, Z. Parnicka1, J. Michalik2, D. Copikova-Cudrakova3, I. Shawkatova1, V. Durmanova1, K. Gmitterova4, E. Klimova5, M. Buc1, M. Bucova1;
Institute of Immunology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia, 2Neurology Clinic, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia,
3
1st Department of Neurology, Faculty of Medicine, Comenius University in Bratislava and University Hospital, Bratislava, Slovakia, 42nd Department of Neurology, Faculty of Medicine, Comenius University
in Bratislava and University Hospital, Bratislava, Slovakia, 5Department of Neurology, Teaching Hospital of J.A. Reiman and Faculty of Health, University of Presov, Presov, Slovakia.
Wednesday
M. Moaaz;
Medical Research Institute, Alexandria University, Alexandria, Egypt.
1
P.B.33.22
Association of PTPN22 mRNA expression with the disease activity markers IL-10, OAS2 and CD70 in patients with systemic lupus erythematosus
J. R. Machado-Contreras1, J. F. Muñoz-Valle1, A. Cruz1, D. C. Salazar-Camarena1, M. Marín-Rosales2, C. A. Palafox-Sánchez1;
1
Instituto de Investigación en Ciencias Biomédicas, Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico, 2Departamento de
Inmunología y Reumatología del Hospital General de Occidente, Secretaria de Salud Jalisco, Zapopan, Mexico.
P.B.34 Multiple Sclerosis
Chairpersons: Hans Lassmann; Vienna, Austria / Roland Liblau; Toulouse, France
P.B.34.01
Increased CD4+ T cell reactivity to citrullinated myelin in the context of HLA-DR4 with progression of demyelinating disease
P.B.34.02
Key role of CXCL10/ IP10 in Multiple Sclerosis Onset
P.B.34.03
Functional analysis of SNP rs630923 located in the promoter of CXCR5 gene and associated with risk of multiple sclerosis
P.B.34.04
Maternally or adult acquired probiotic E. coli Nissle 1917 suppresses central nervous system inflammation
P.B.34.05
Role of transcriptional silencers Ets-2 and FoxP3 in the pathogenesis of multiple sclerosis (MS)
A. Kersh, B. Evavold;
Emory University, Atlanta, GA, United States.
L. Fernández-Paredes1, A. Casrouge2, J. Decalf2, C. de Andrés3, R. Pérez de Diego4, B. Alonso1, L. Villar5, J. Álvarez Cermeño5, R. Arroyo6, M. Tejera-Alhambra7, J. Navarro7, C. Oreja-Guevara8, M. LópezTrascasa9, A. Seyfferth10, M. García Martínez8, R. Álvarez-Lafuente8, M. L. Albert2, S. Sánchez Ramón1;
1
Hospital Clínico San Carlos, Servicio de Inmunología., Madrid, Spain, 2Institut Pasteur,Laboratory of Dendritic Cell Biology, Paris, France, 3Hospital General Universitario Gregorio Marañón, Servicio de
Neurología., Madrid, Spain, 4Instituto de Investigación de la Salud IdiPAZ, Laboratorio de Inmunogenética., Madrid, Spain, 5Hospital Hospital Ramón y Cajal, Servicio de Inmunología., Madrid, Spain,
6
Hospital Clínico San Carlos, Servicio de Neurología, Madrid, Spain, 7Hospital General Universitario Gregorio Marañón, Servicio de Inmunología., Madrid, Spain, 8Hospital Clínico San Carlos, Servicio de
Neurología., Madrid, Spain, 9Hospital Universitario La Paz, Servicio de Inmunología., Madrid, Spain, 10STAT-UP Statistical Consulting&Services, Madrid, Spain.
N. A. Mitkin1, A. M. Schwartz1, A. M. Muratova1,2, D. V. Kuprash1,2,3;
1
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation, 2Department of Immunology, Faculty of Biology, Lomonosov Moscow State University, Moscow,
Russian Federation, 3Institute of Molecular Biology and Regional Ecology, Lobachevsky State University of Nizhni Novgorod, Nizhni Novgorod, Russian Federation.
T. Secher, S. Kassem, M. Boury, I. Bernard-Cadenat, E. Oswald, A. Saoudi;
INSERM-CPTP, Toulouse, France.
I. Panagoulias1, F. Karagiannis1, S. Anastasopoulou1, I. Aggeletopoulou1, S. Prekatsakis2, P. Papathanasopoulos2, T. Georgakopoulos1, A. Mouzaki1;
Division of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Patras, Rion, Patras, Greece, 2Department of Neurology, Patras University Hospital, Patras, Greece, Rion,
Patras, Greece.
1
P.B.34.06 Glial iron management in multiple sclerosis
S. Hametner1, J. Zarruk2, S. David2, H. Lassmann1;
1
Center for Brain Research, Medical University of Vienna, Vienna, Austria, 2Center for Research in Neuroscience, The Research Institute of The McGill University Health Center, Montreal, QC, Canada.
P.B.34.07
CD56bright/CD56dim NK ratio specifically increases in cerebrospinal fluid of multiple sclerosis patients
E. Rodriguez-Martin1, C. Picon1, L. Costa-Frossard2, R. Alenda1, S. Sainz de la Maza2, E. Roldan1, M. Espiño1, J. C. Alvarez-Cermeño2, L. M. Villar1;
1
Department of Immunology, Hospital Ramon y Cajal, Madrid, Spain, 2Department of Neurology, Hospital Ramon y Cajal, Madrid, Spain.
P.B.34.09 The topography of Multiple Sclerosis lesions in the brain reveals insights into the mechanisms of demyelination and neurodegeneration
T. Zrzavy, L. Haider, S. Hametner, H. Lassmann;
Medical University Vienna, Center for brain research, Vienna, Austria.
P.B.34.10
Results of a centralized unit for the assessment of oligoclonal bands in patients with neurological diseases
I. Toboso1, A. Tejeda1, M. Espiño1, E. Fernández-Díaz2, L. Brieva1, A. B. Caminero1, L. Gabaldón1, I. García-Castañón1, J. L. Sánchez-Menoyo1, M. Muñoz-Pasadas1, F. Pérez-Parra1, E. Durán1, V. Meca3, L.
Gómez1, C. Arnal1, D. Muñoz-García1, A. Muñóz-Málaga1, J. C. Álvarez-Cermeño1, L. M. Villar-Guimerans1;
1
Ramón y Cajal Hospital. IRYCIS, Madrid, Spain, 2Hospital universitario de Albacete, Albacete, Spain, 3La Princesa Hospital, Madrid, Spain.
95
P.B.34.11
Ameliorating effects of Sesamum indicum seeds oil on animal model of multiple sclerosis
P.B.34.13
Association of TREM-1 A/T SNP polymorphism (rs2234237) with the risk of multiple sclerosis in Slovak population
P.B.34.14
CX3CR1-dependent recruitment of mature NK cells into the CNS contributes to the control of CNS autoimmunity
P.B.34.15
Foxp3+ cells are present and produce both pro- and anti- inflammatory cytokines in lesions of multiple sclerosis patients
P.B.34.16
T helper cells 1/17-related genes in interferon-β-treated relapsing-remitting multiple sclerosis patients - correlation to clinical status
M. Zamani;
Department of Immunology & Biology,Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
B. Gajdosechova1, M. Bucova1, J. Javor2, P. Turčani3, D. Cudrakova-Copikova3, J. Michalik4;
1
Institute of Immunology, School of Medicine, Comenius University, Bratislava, Slovakia, 2Institute of Immunology, Scool of Medicine Comenius University, Bratislava, Slovakia, 3Ist Department of
Neurology, School of Medicine Comenius University, Centre for MS therapy,, Bratislava, Slovakia, 4Department of Neurology, Jesenius School of Medicine Comenius University, Martin, Slovakia.
L. Hertwig1, S. Romero Suarez1, J. M. Millward1, H. Stuis1, R. M. Ransohoff2, A. Cardona3, C. Infante Duarte1;
1
Universitätsklinikum Charité Berlin, Institute for Medical Immunology, Berlin, Germany, 2Lerner Research Institute, Department of Neurosciences, Cleveland, OH, United States, 3University of Texas at San
Antonio, Department of Biology, San Antonio, TX, United States.
S. E. Zandee1, M. D. Leech1, A. Williams2, S. M. Anderton1;
1
University of Edinburgh, MRC Centre for Inflammation Research, Centre for Multiple Sclerosis Research, Queen’s Medical Research Institute, Edinburgh, United Kingdom, 2University of Edinburgh, MRC
Centre for Regenerative Medicine, Centre for Multiple Sclerosis Research, Edinburgh, United Kingdom.
E. Milošević1, I. Dujmovic2, M. Markovic1, S. Mesaros2, J. Drulovic2, M. Mostarica Stojkovic1, D. Popadic1;
Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Belgrade, Serbia, 2Neurology Clinic, Clinical Centre of Serbia, School of Medicine, University of Belgrade, Belgrade,
Serbia.
1
P.B.34.18
Inflammatory response in Multiple Sclerosis lesions
P.B.34.19
Rai promotes astrocyte-dependent inflammation during experimental autoimmune encephalomyelitis
P.B.34.20
Mannan-conjugated myelin peptides induce dendritic cell (DC)-driven tolerogenic response
J. Machado-Santos, E. Saji, J. Bauer, H. Lassmann;
Center for Brain Research, Vienna, Austria.
C. Ulivieri1, M. Savino1, I. Luccarini2, E. Fanigliulo1, A. Aldinucci2, E. Bonechi2, M. Benagiano2, B. Ortensi3, G. Pelicci3, M. D’Elios2, C. Ballerini2, C. T. Baldari1;
1
University of Siena, Siena, Italy, 2University of Florence, Florence, Italy, 3European Institute of Oncology, Milan, Italy.
M. Rodi1, A. de Lastic1, S. Prekatsakis2, I. Panagoulias1, P. Spadidea1, A. Tapinou3, T. Tselios3, I. Matsoukas3, P. Papathanasopoulos2, A. Mouzaki1;
1
Division of Hematology, Dept. of Internal Medicine, Faculty of Medicine, University of Patras, Patras, Greece, 2Department of Neurology, Patras University Hospital, Patras, Greece, 3Department of
Chemistry, University of Patras, Patras, Greece.
P.B.35 Immuneregulation at Barrier Sites - Part 1
Chairpersons: Nadine Cerf-Bensussan; Paris, France / Verena Niederberger-Leppin; Vienna, Austria (tbc)
Wednesday
P.B.35.01
Function of the Aryl hydrocarbon Receptor Repressor during polymicrobial and parasitic infections
P.B.35.02
Regulation of AhRR expression through environmental AhR ligands in intestinal immune cell subsets
P.B.35.03
Changes of the Wnt signalling in bronchial epithelial cells can affect the immune response in asthma
P.B.35.04
Oral cadmium intake and immune responses in the gut: intestinal inflammation and immune priming of mesenteric lymph nodes
P.B.35.05
Zonulin level correlates with density of enteroviruses and tolerogenic dendritic cells in small bowel mucosa in celiac disease patients
P.B.35.06
Chemerin is an antimicrobial agent in mouse skin
P.B.35.07
Influence of the microbiome in regulating ConA-induced-liver injury
P.B.35.08
Langerhans cells (CD1a and CD207), dermal dendrocytes (FXIIIa) and plasmacytoid dendritic cells (CD123) in skin lesions of leprosy patients
P.B.35.09
Re-examining urban endotoxins: abundance and inflammatory capacity in polluted air
P.B.35.10
Abnormal humoral immune response to oral antigens casein and ovalbumin in complement C3-deficient patients
J. König1, J. Vorac1, D. Degrandi2, K. Pfeffer2, H. Weighardt1,3, I. Förster1;
1
LIMES Intsitute, Bonn, Germany, 2Institute of Medical Microbiology and Hospital Hygiene, Düsseldorf, Germany, 3IUF Leibniz-Institut für Umwelt-medizinische Forschung, Düsseldorf, Germany.
O. Schanz, O. Brandstätter, H. Weighardt, I. Förster;
LIMES-Institute, Bonn, Germany.
K. Dietz1, H. Baarsma2, M. Königshoff2, C. Schmidt-Weber1, K. Suttner1;
1
ZAUM - Centre of Allergy and Environment, Technische Universität München (TUM), Helmholtz Centre Munich and member of German Centre for Lung Research (DZL), München, Germany, 2CPCComprehensive Pneumology Centre, Ludwig-Maximilians-Universität München (LMU), Helmholtz Centre Munich and member of German Centre for Lung Research (DZL), München, Germany.
M. Ninkov1, A. Popov Aleksandrov1, J. Demenesku1, I. Mirkov1, D. Mileusnic1, M. Tolinacki2, L. Zolotarevski3, D. Kataranovski1,4, I. Brceski5, M. Kataranovski1,6;
1
Department of Ecology, Institute for Biological Research “Sinisa Stankovic”, University of Belgrade, Belgrade, Serbia, 2Institute of Molecular Genetics and Genetic Engineering, Laboratory for Molecular
Microbiology, University of Belgrade, Belgrade, Serbia, 3Institute of Pathology, Military Medical Academy, Belgrade, Serbia, 4Faculty of Biology, Institute of Zoology, University of Belgrade, Belgrade, Serbia,
5
Faculty of Chemistry, University of Belgrade, Belgrade, Serbia, 6Institute of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
T. Vorobjova1, H. Raikerus1, O. Uibo2, K. Heilman3, R. Uibo1;
1
University of Tartu, Department of Immunology, Institute of Biomedicine and Translational Medicine, Tartu, Estonia, 2Department of Pediatrics, University of Tartu; Children’s Clinic of Tartu University
Hospital, Tartu, Estonia, 3Department of Pediatrics, University of Tartu; Tallinn’s Children’s Hospital, Tartu, Estonia.
A. Zegar1, M. Banas1, B. Zabel2, J. Cichy1;
1
Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland, 2Palo Alto Veterans Institute for Research, VA Palo Alto Health Care System,
Palo Alto, CA, United States.
B. Schiller1, C. Wegscheid1, A. Rehman2, A. Horst1, P. Rosenstiel2, G. Tiegs1;
1
Institute of Experimental Immunology and Hepatology, Hamburg, Germany, 2Institute of Clinical Molecular Biology, Kiel, Germany.
J. A. Quaresma1,2, H. Fuzii1, K. Hirai1,2, T. Aaarão1,2, L. Mota1,2, J. Sousa1;
1
Federal University of Para, Belem, Brazil, 2State University of Para, Belem, Brazil.
S. A. Moretti, E. Oerlemans, S. Lebeer;
University of Antwerp, Antwerpen, Belgium.
P. T. Pekkarinen1, M. Helminen2, S. Meri1,3, H. Jarva1,3, T. P. Arstila1;
Haartman Institute and Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland, 2The Paediatric Research Centre, Tampere University and University Hospital, Tampere, Finland,
3
HUSLAB and Helsinki University Central Hospital, Helsinki, Finland.
1
P.B.35.11
MyD88 signaling in dendritic and intestinal epithelial cells is sufficient for protection against intestinal bacterial infection
P.B.35.12
Characterization of the mouse NKC-encoded intestine-specific glycoprotein Clr-a
P.B.35.13
Rapid activation of the mTOR pathway in human resident lamina propria macrophages during the initiation of intestinal inflammation
P.B.35.14
Laminin-derived peptides are involved in inflammation, wounding and skin infections
C. Friedrich1, P. Mamareli1, Z. Wang1, S. Hagemann1,2, T. Sparwasser1, M. Lochner1;
1
Institute of Infection Immunology, Twincore, Hannover, Germany, 2Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
E. Rutkowski, S. Leibelt, A. Steinle;
J. Gras1, A. Heninger1, F. Lasitschka1, M. Dinkelacker2, G. Wabnitz1, M. Al Saeedi1, B. Jocher1, T. Giese1, S. Meuer1, J. Schröder-Braunstein1;
1
University Hospital Heidelberg, Heidelberg, Germany, 2DKFZ, Heidelberg, Germany.
I. Aschermann1, G. Klein2, H. Kalbacher2, B. Schittek1;
Department of Dermatology, University of Tübingen, Tübingen, Germany, 2University of Tübingen, Tübingen, Germany.
1
96
P.B.35.15
Basolateral sphingosine-1-phosphate regulates barrier function in polarized intestinal epithelial cells
P.B.35.17
Spatiotemporal Interplay of Severe Acute Respiratory Syndrome Coronavirus and Respiratory Mucosal Cells Drives Viral Dissemination in Rhesus Macaques
E. Fuerst, S. C. Diesner, S. Exenberger, E. Untersmayr;
L. Liu, K. Nishiura, J. Peng, Z. Chen;
The University of Hong Kong, Hong Kong, Hong Kong.
P.B.35.18
Delineating the role of indoleamine 2,3-dioxygenase-1 in the pathogenesis of staphylococcal superantigen-induced toxic Shock syndrome using humanized mice
P.B.35.19
Parvalbumin and matrix components from Atlantic cod induce differential gene expression of cytokines and chemokines in intestinal and airway epithelia
T. Rutherford, G. Rajagopalan;
T. Kalic1, I. Ellinger1, E. Waltl2, V. Niederberger2, H. Breiteneder1;
1
Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria, 2Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
P.B.36 Immuneregulation at Barrier Sites - Part 2
Chairpersons: Maureen McGargill; Memphis, United States / Per Brandtzaeg; Oslo, Norway
P.B.36.01
The protective effect of the skin barrier against bacterial infection is influenced by its microbiota and the interplay of bacteria and host-derived bioactive peptides
P.B.36.02
A broncho-epithelial co-culture model to study mucosal defense after Bordetella Pertussis booster vaccination in children 4 year of age
P.B.36.03
The prognostic value of the neutrophil / lymphocyte ratio in patients with snake bites for clinical outcomes and complications
M. S. Burian, B. Kraft, B. Schittek;
University Hospital Tübingen Detartment of Dermatology, Tübingen, Germany.
M. A. Schijf, A. M. Buisman, G. A. Berbers, F. R. van der Klis;
National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
B. Baykal1, B. Elbey2, U. C. Yazgan3;
1
Dicle University, Faculty of Medicine,Departments of Medical Biology & Genetics, Diyarbakır, Turkey, 2Dicle Univercity, Faculty of Medicine. Department of Immunology, Diyarbakır, Turkey, 3Dicle Univercity,
Faculty of Medicine. Department of Physiology, Diyarbakır, Turkey.
P.B.36.04 Elevated expression of programmed cell death-1 antigen on the surface of T lymphocytes in patients with idiopathic dilated cardiomyopathy
D. Stettner-Leonkiewicz, E. Grywalska, J. Rolinski, A. Wysokinski;
Medical University of Lublin, Lublin, Poland.
P.B.36.05
Anti-inflammatory Immune Regulation by Anionic Phospholipids in nARDS
S. Kupsch1, D. Spengler2, M. Krause2, S. Schütze3, H. Fehrenbach4, A. B. Schromm1;
Division of Immunobiophysics, Research Center Borstel, Borstel, Germany, 2Center for Pediatrics, University Hospital, Kiel, Germany, 3Institute of Immunology, Christian-Albrechts-University, Kiel,
Germany, 4Division of Experimental Pneumology, Research Center Borstel, Borstel, Germany.
1
P.B.36.06 The gut barrier failure in indometacin model of intestinal injury is dependent on type of colonization
M. Hornova1, Z. Zakostelska1, H. Tlaskalova-Hogenova1, T. Hudcovic2, H. Drasarova1, K. Klimesova1, J. Malkova1, M. Kverka1;
1
Institute of Microbiology of the ASCR, Prague, Czech Republic, 2Institute of Microbiology of the ASCR, Novy Hradek, Czech Republic.
Lysate of Lactobacillus casei DN-114 001 strengthen the gut barrier function in mice
Z. Zakostelska1, M. Kverka1, K. Klimesova1, P. Rossmann1, J. Mrazek2, J. Kopecny2, M. Hornova1, D. Srutkova3, T. Hudcovic3, J. Ridl4, H. Tlaskalova-Hogenova1;
1
Institute of Microbiology of the ASCR, Prague, Czech Republic, 2Institute of Animal Physiology and Genetics of the ASCR, Prague, Czech Republic, 3Institute of Microbiology of the ASCR, Novy Hradek,
Czech Republic, 4Institute of Molecular Genetics of the ASCR, Prague, Czech Republic.
P.B.36.08 Deciphering the intestinal microbiota-driven modulation of regulatory T cells responses using a functional metagenomic approach
N. Lapaque, C. Martin-Gallausiaux, T. Santos-Lacerda, A. Cultrone, F. Ledue, T. de Wouters, J. Doré, H. Blottiere;
INRA, MICALIS UMR1319, Jouy-en-Josas, France.
P.B.36.09 Unravelling the dynamics of mucosal immune response during Clostridium difficile infection
I. Marszalowska1, M. Lynch1, A. Ravida2, C. E. Loscher1;
1
Immunomodulation Laboratory, Dublin City University, Dublin, Ireland, 2Parasite Immunomodulation Laboratory, Dublin City University, Dublin, Ireland.
P.B.36.10
Investigation of the relation between anaerobic bacteria genus Clostridium and late-onset autism etiology in children
P.B.36.11
Methanoarchaea as part of the human microbiota: Friends or Foes?
P.B.36.12
Alteration of gut microbiota affects tumor development in the mouse model of inflammation-related tumorigenesis
P.B.36.14
Deriving germfree zebrafish larvae to study the impact of the microbiota on the innate immune response to bacterial infection
P.B.36.15
Role of anti-oxidative stress pathways for T cell differentiation and intestinal immune regulation in neuroinflammation
R. Kesli1, C. Gökcen2, U. Buluğ3, Y. Terzi4;
1
Department of Medical Microbiology , School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey, 2Department of Child and Adolescent Psychiatry, School of Medicine, Gaziantep University,
Gaziantep, Turkey, 3Department of Child and Adolescent Psychiatry, Konya Education and Research Hospital, Konya, Turkey, 4Department of Statistics, Faculty of Arts and Sciences, Ondokuz Mayıs
University, Samsun, Turkey.
Wednesday
P.B.36.07
C. Bang1,2, K. Weidenbach2, T. Gutsmann1, H. Heine1, R. A. Schmitz2;
1
Research Center Borstel, Borstel, Germany, 2Christian-Albrechts-University Kiel, Kiel, Germany.
K. Klimesova1,2, J. Malkova1, M. Kverka1,3, H. Tlaskalova - Hogenova1;
1
Institute of Microbiology, ASCR, Prague, Czech Republic, 2Institute of Molecular Genetics ASCR, Prague, Czech Republic, 3Institute of Experimental Medicine ASCR, Prague, Czech Republic.
A. C. King, R. Lawrence, I. McGonnell;
Royal Veterinary College, London, United Kingdom.
A. Hammer1, S. Jörg1, A. Haghikia2, D. Lee1, R. Gold2, R. A. Linker1;
1
University Hospital Erlangen, Erlangen, Germany, 2St. Josef Hospital Bochum/Ruhr-University Bochum, Bochum, Germany.
P.B.36.16 Studying the effect of the skin microbiome on the barrier properties of human keratinocytes
B. S. Bolla1, G. Tax1, L. Erdei1, E. Urbán2, L. Kemény1,3, K. Szabó3;
1
Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary, 2Institute of Clinical Microbiology, University of Szeged, Szeged, Hungary, 3MTA-SZTE Dermatological Research
Group, Szeged, Szeged, Hungary.
P.B.36.17
Dysregulation of ERK signaling in CD4-expressing cells induces osteochondromas
M. Wehenkel1, M. Corr2, C. Guy1, B. A. Edwards1, C. Calabrese1, G. Pages3, J. Pouyssegur3, P. Vogel1, S. Hedrick2, M. A. McGargill1;
1
St. Jude Children’s Research Hospital, Memphis, TN, United States, 2University of California, San Diego, La Jolla, CA, United States, 3Institute for Research of Cancer & Aging (IRCAN), University of Nice
Sophia-Antipolis, Nice, France.
P.B.36.18 The participation of the urokinase-type plasminogen activator on inflammatory cell migration
B. R. C. Costa1,2, J. P. Vago1,2,3, A. F. Carmo1,2, L. C. Oliveira4, L. P. Tavares1,2, K. M. Lima1,2,3, A. S. Barbosa2, B. F. Brasil4, L. S. Barcelos2, C. A. Bonjardim4, M. M. Teixeira2, L. P. Sousa1,2;
1
Clinical and Toxicological Analysis Department, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, 2Immunopharmacology Laboratory, Biochemistry and Immunology
Department, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, 3Post-Graduation Program on Cell Biology, Morphology Department, Institute of Biological
Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, 4Microbiology Department, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
P.B.37 Cytokines in Regulation of Disease
Chairpersons: Tobias Bopp; Mainz, Germany / Wenling Wang; Beijing, China (tbc)
P.B.37.01
MERS-CoV ORF4b inhibits the type I interferon signaling pathway through direct interaction with IKKε and TBK1 as well as enforces in the nucleus
P.B.37.02
PD-L1 controls the Th1 immune response in experimental Glomerulonephritis
P.B.37.03
Saffron aqueous extract (Crocus sativus L.) attenuate TNF-α and IL-6 in STZ-induced diabetic rat aorta
P.B.37.04
The Role of Previous Thyroid State in T-cell Mediated Immunity and Chemotherapy Response in New Cases of Tuberculosis
W. Tan, Y. Yang, Y. Deng, W. Wang;
National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
A. Ostmann1, H. Paust2, U. Panzer2, G. Tiegs1;
1
Experimental Immunology and Hepatology, University Medical Clinic Hamburg-Eppendorf, Hamburg, Germany, 2III.Medical Clinic, University Medical Clinic Hamburg-Eppendorf, Hamburg, Germany.
S. Samarghandian, M. Azimi-Nezhad;
Neyshabur University of Medical Sciences, Neyshabur, Iran, Islamic Republic of.
D. O. Butov1, S. O. Cherenko2, S. L. Matveyeva1, O. S. Shevchenko1, I. M. Kalmikova3;
1
Kharkiv National Medical University, Kharkiv, Ukraine, 2National Institute of Phthisiology and Pulmonology after named F.G.Yanovsky of Ukrainian NAMS, Kiev, Ukraine, 3Kharkiv Regional Antituberculosis
Dispensary N 1, Kharkiv, Ukraine.
97
P.B.37.05
LPS-induced TNF-α production is governed by SFKs in PBMC of patients with Behçet’s disease
P.B.37.06
Atypical chemokine receptor ACKR4 regulates the formation of lymphoid aggregates in a model of tertiary lymphoid organ formation in the salivary glands
P.B.37.07
A dysregulated IFN-γ+ memory T helper cell subpopulation in NZB/W F1 Lupus prone mice exhibits features of a partially exhausted phenotype
P.B.37.08
STAT5 activation in Systemic Lupus Erythematosus
P.B.37.09
Cytokine production in winter sport’s elite athletes with various body and muscle mass
S. Irtegun, M. F. Turkcu, Z. M. Akkurt, S. Kalkanlı, M. Bozkurt;
Dicle University, Diyarbakır, Turkey.
J. Campos1, B. Lucas2, S. Nayar1, K. Toellner2, C. D. Buckley1, A. Rot3, F. Barone1;
1
Centre for Translational Inflammation Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, 2School of Immunity
and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, 3Centre for Immunology and Infection, Department of Biology, University of York, York,
United Kingdom.
A. Abajyan1, M. Venzke1, T. Scheel1, T. Lischke1, G. Riemekasten2, R. Baumgrass1;
1
German Rheumatism Research Center (DRFZ), Berlin, Germany, 2Charité University Medicine Berlin, Berlin, Germany.
S. S. Meshaal, R. E. El Hawary, A. El Saie, R. El Refai;
Faculty of Medicine, Cairo University, Cairo, Egypt.
R. Khanferyan1, R. Radzhabkadiev1, T. Solntseva1, V. Sjomin1, N. Fedjanina1, A. Samoilov2, J. Dorofeeva1;
Institute of Nutrition, Moscow, Russian Federation, 2Center of Sport Medicine FMBA, Moscow, Russian Federation.
1
P.B.37.10
STAT1α and STAT1β in vivo: a delicate balance during innate immunity?
P.B.37.11
Season dependent changes in the expression of protein kinase C isoenzymes in the mononuclear cells of a pateint with acut systemic lupus erythematosus and in
her parents
M. Parrini1, C. Semper1, A. Puga1, C. Lassnig1,2, N. R. Leitner1, K. Lorenz1, T. Decker3, M. Müller1,2, B. Strobl1;
1
Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria, 2Biomodels Austria, University of Veterinary Medicine, Vienna, Austria, 3Max F. Perutz Laboratories, University
of Vienna, Vienna, Austria.
S. Sipka, B. Brúgos, G. Czifra, Z. Griger, N. Balogh, T. Tarr, T. Bíró, M. Zeher;
University of Debrecen, Debrecen, Hungary.
Wednesday
P.B.37.12
T cell subsets and cytokines in selected acute crisis states
P.B.37.14
Immune-related protein signature in pseudosynovial tissue from patients with various stages of periprosthetic osteolysis in total knee arthroplasty
P.B.37.15
T-regulatory profile of mRNA gene expression in chronic inflammatory arthritides
P.B.37.16
Targeting Thymic Stromal Lymphopoietin in Airway Epithelium Alleviated Inflammation Through CCL17 in A Murine Asthma Model
P.B.37.17
Cytokine spectrum shows an individual pattern in patients with undifferentiated arthritis and differs from healthy controls
P.B.37.18
Activation of immune splenocytes response to venom components: in vivo and ex vivo murine models
P.B.37.19
Characteristic of immune response during herpes simplex virus infection in childhood
P.B.37.20
IL-17AF signaling deficient mice show spontaneous infections with Staphylococcus aureus concomitant with expanded populations of γδ T cells
P.B.37.21
Early growth response gene (Egr) 2 and 3 regulate interferon gamma expression in activated CD4 T cells by controlling Tbet activity
P.B.37.22
Investigating genetic polymorphisms in relation to asymptomatic Clostridium difficile infection
P.B.37.23
Conditional IL1R1 deficient mice
P.B.37.24
Acute inflammation is diminished in mice eating western diet
B. O. Musa, G. C. Onyemelukwe;
Immunology Unit, Department of Medicine, A.B.U.Teaching hospital, Zaria, Nigeria.
T. Dyskova1, J. Gallo2, P. Schneiderova1, R. Fillerova1, E. Kriegova1;
1
Dept. of Immunology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic, 2Dept. of Orthopaedics, Faculty of Medicine and Dentistry, Palacky University and University
Hospital, Olomouc, Czech Republic.
L. Miteva1, I. Manolova2, M. G. Ivanova3, R. Stoilov3, S. A. Stanilova1;
1
Trakia University, Medical Faculty, Department of Molecular Biology, Immunology and Medical genetics, Stara Zagora, Bulgaria, 2Trakia University, Medical Faculty, Stara Zagora, Bulgaria, 3Clinic of
Rheumatology, University Hospital, Medical University, Sofia, Bulgaria.
Y. L. Chen1, B. L. Chiang1,2;
1
E. Brzustewicz1, I. Henc1, A. Daca1, M. Szarecka2, M. Sochocka- Bykowska2, E. Bryl1;
1
Medical University of Gdańsk, Gdańsk, Poland, 2Voivodal Rheumatology Hospital, Sopot, Poland.
H. Saidi, D. Khemili, c. Saidani, F. Laraba-Djebari, D. Hammoudi-Triki;
University of Sciences and Technology Houari Boumédiène, Algiers, Algeria.
H. M. Stamenkovic, L. Saranac, L. Brankovic, R. Milicevic, B. Kamenov;
Clinic of Pediatric, Nis, Serbia.
S. Moos1, A. P. Heinen1, T. Regen1, S. Voglis1, K. El Malki1, F. Wanke1, I. Prinz2, A. Diefenbach3, A. Waisman1, F. C. Kurschus1;
1
Institute for Molecular Medicine, Mainz, Germany, 2Institute of Immunology, Hannover, Germany, 3Institute for Medical Microbiology and Hygiene, Mainz, Germany.
R. Singh1, T. Miao2, A. J. Symonds2, B. Omodho1, S. Li1, P. Wang2;
1
Brunel University London, College of Health and Life Science, Heinz Wolff, Uxbridge, London, United Kingdom, 2Barts and the London School of Medicine and Dentistry, Blizzard Institute, Queen Mary
University of London, London, United Kingdom.
R. Biggart, S. Caserta, M. Llewelyn;
Brighton and Sussex Medical School, Brighton, United Kingdom.
W. Abdulaal, R. Costello, C. Walker, E. Pnteaux, W. Muller;
Faculty of Life Science, Manchester, United Kingdom.
A. Kielland1, O. A. Haabeth2, H. Carlsen1;
Norwegian University of Life Sciences, Aas, Norway, 2University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway.
1
P.B.37.25
Association of IL-10 gene polymorphism with diabetic nephropathy in patients from the western Mexico
L. E. Chavarria Buenrostro1, J. G. Macias-Barragan2, J. F. Muñoz Valle3, J. Hernandez Bello4, P. E. Sánchez Hernández5, M. G. Ramírez Dueñas6, J. Armendariz Borunda7, N. Torres Carrillo3, N. M. Torres
Carrillo3, T. García Iglesias6, M. Montoya Buelna6;
1
Universidad de Guadalajara, Guadalajara, Mexico, 2Departamento de Ciencias Naturales y Exactas, Cu Valles, Universidad de Guadalajara, Guadalajara, Mexico, 3Instituto de Investigación en Ciencias
Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico, 4Instituto de investigación en ciencias biomédicas, centro universitario de ciencias de la salud,
Universidad de Guadalajara, Guadalajara, Mexico, 5Laboratorio de Inmunología, departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico,
6
Laboratorio de Inmunología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico, 7Departamento de Biología Molecular y Genómica,
Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
Chairpersons: Edward Knol; Utrecht, Netherlands / Eva Sverremark-Ekstrom; Stockholm, Sweden
P.B.38.01
Contact sensitizers alter CD1-specific immunity
R. J. Betts1, S. Mahapatra2, S. Martinozzi Teissier2, G. De Libero3,4, L. Mori4;
L’Oreal Research and Innovation, Singapore, Singapore, 2L’Oreal Research and Innovation, Aulnay-sous-Bois, France, 3Department of Biomedicine, University Hospital Basel, Basel, Switzerland,
4
Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
1
P.B.38.02
CD23 density on B cells is an important parameter for IgE facilitated allergen presentation and allergen-specific T cell activation
R. Selb1, J. Eckl-Dorna1, A. Neunkirchner2, W. F. Pickl2, R. Valenta3, V. Niederberger1;
Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria, 2Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna,
Vienna, Austria, 3Divison of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna,
Austria.
1
98
P.B.38.03
Modulation of IgA and IgG immunoreactivity to gliadin and glutenin by sprouting and steeping of wheat kernels
M. Zrnic Ciric1, S. Zilic2, I. Stankovic1, M. Jankovic2, J. Antic-Stankovic3, A. Konic Ristic4;
1
Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia, 2Department of Food Technology and Biochemistry, Maize Research Institute, Belgrade-Zemun, Serbia,
3
Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia, 4Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research,
University of Belgrade, Belgrade, Serbia.
P.B.38.04 Recombinant species-specific FcεRI alpha chain proteins for allergy diagnosis of dogs, cats and horses
L. Einhorn1,2, J. Fazekas1,2, M. Muhr1,2, A. Schoos1,2, L. Panakova3, I. Herrmann3, K. Manzano-Szalai1, K. Oida1,4, E. Fiebiger5, J. Singer2, E. Jensen-Jarolim1,2;
1
Comparative Medicine, Messerli Reasearch Institute, Vienna, Austria, 2Institute of Pathophysiology and Allergy Reasearch, Medical University of Vienna, Vienna, Austria, 3Department for Companion
Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria, 4Laboratory of Veterinary Molecular Pathology and Therapeutics, Tokyo University of Agriculture and Technology, Tokyo,
Japan, 5Division of Gastroenterology and Nutrition, Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, United States.
P.B.38.05
Sensitization patterns of buckwheat-allergic patients
S. Pfeifer1, P. Dubiela1, A. C. Pedersen2, M. Bublin1, R. Aina1, P. Humeniuk1, C. Bindslev-Jensen2, C. Gotthard Mørtz2, K. Hoffmann-Sommergruber1;
1
Medical University of Vienna, Vienna, Austria, 2Odense University Hospital, Odense, Denmark.
P.B.38.06 Dissection of specific IgG responses with recombinant house dust mite allergens reveals that poor effect of specific immunotherapy is due to failure of blocking
antibody induction towards certain allergens
K. Chen1, R. Zieglmayer2, P. Zieglmayer2, P. Lemell2, F. Horak2, R. Valenta1, S. Vrtala1;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Vienna
Challenge Chamber, Allergy Center Vienna West, Vienna, Austria.
P.B.38.07
Novel cassette vectors for the targeted expression of HLA class II molecules for presentation of human-relevant allergens in murine models of allergy
B. Kratzer1, A. Neunkirchner1, R. Naumann2, W. F. Pickl1;
1
Institute of Immunology; Center for Pathophysiology, Infectiology and Immunology; Medical University, Vienna, Austria, 2Max Planck Institute of Molecular Cell Biology and Genetics; Transgenic Core
Facility; Dresden, Dresden, Austria.
P.B.38.08 The placement of novel in-vitro diagnostic tests in Hymenoptera sting allergy diagnosis
J. Šelb, M. Košnik, M. Šilar, P. Korošec;
P.B.38.09 IgE and IgG subclasses to αGal in meat-allergic patients
D. Kollmann1,2, C. Ebner3, W. Emminger4, A. Mangold1, H. J. Ankersmit1, B. Bohle2;
1
Department of Surgery, Medical University of Vienna, Vienna, Austria, 2Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria, 3Allergy Clinic Reumannplatz,
Vienna, Austria, 4Allergy Clinic Rennweg, Vienna, Austria.
P.B.38.10
Exacerbation of allergic asthma by Moraxella catarrhalis infection is mediated by IL-17
P.B.38.11
Towards establishing an adoptive transfer model for initiation and progression of allergic airways hyperresponsiveness in humanized allergy mice
P.B.38.12
Suppressive effects of Hsp70 on activated neutrophils in allergic airway inflammation
P.B.38.13
The immune response against major grass pollen allergen Phl p 5 in non-allergic humans
B. Srinivasan, A. Neunkirchner, W. F. Pickl;
Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
M. A. Shevchenko1, N. I. Troyanova1, A. M. Posyovskaya1,2, E. A. Servuli1,3, A. M. Sapozhnikov1;
1
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russian Federation, 2Lomonosov Moscow State University, Moscow, Russian Federation, 3Pirogov Russian National Research
Medical University, Moscow, Russian Federation.
A. Isakovic1, C. Hillebrand1, G. Fichtinger1, M. Danzer2, C. Gabriel2, T. Thalhamer1, S. Scheiblhofer1, J. Thalhamer1, R. Weiss1;
University of Salzburg, Salzburg, Austria, 2Red Cross Blood Transfusion Service, Linz, Austria.
1
P.B.38.14
Diagnostic challenges in patients with perennial rhinitis
P.B.38.15
Birch pollen-allergic patients have increased serum levels of the chemokines CCL11, CCL17, CCL22, CXCL9, CXCL10 and decreased serum levels of CXCL1 out of the
pollen season
Wednesday
S. Alnahas1, U. Steinhoff1, H. Garn2, S. Hagner3;
1
Institut für Med.Mikrobiologie, Marburg, Germany, 2Institute for Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics,, Marburg, Germany, 3Institute for Laboratory Medicine and
Pathobiochemistry, Molecular Diagnostics, Marburg, Germany.
M. Kacar, M. Šilar, R. Eren, P. Kopač, K. Jenko, T. Soklič, I. Kern, P. Koroec, M. Zidarn;
T. G. Batsalova, Z. B. Kostova, D. A. Moten, I. I. Teneva, B. M. Dzhambazov;
Plovdiv University, Plovdiv, Bulgaria.
P.B.38.16 Isolation and characterization of an IgG-derived ScFv specific for the major birch pollen allergen Bet v 1 from a healthy donor immunized with hypoallergenic Bet v
1 fragments: High affinity binding despite germline configuration - challenging the principle of affinity maturation
E. Gadermaier1, K. Marth1, K. Blatt2, C. Lupinek1, U. Roder3, M. Focke-Tejkl1, S. Vrtala1, P. Valent2, R. Valenta1, S. Flicker1;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna General Hospital,
Vienna, Austria, 2Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna General Hospital, Vienna, Austria, 3GE Healthcare Europe GmbH,
Freiburg, Germany.
P.B.38.17
Diagnostics of specific IgE-antibodies to the apple and orange allergens
O. Prylutskyi, K. Tkachenko, N. Abylgazinova;
Department of Clinical Immunology, Allergology and Endocrinology, Donetsk National Medical University, Donetsk, Ukraine.
P.B.38.18 Adaptive IgE effector mechanisms can increase the resistance of mice to Russell’s viper venom
P. Starkl, T. Marichal, N. Gaudenzio, L. L. Reber, R. Sibilano, M. Tsai, S. J. Galli;
Stanford University School of Medicine, Stanford, CA, United States.
P.B.38.19 Development of sandwich ELISAs for the quantification of clinically relevant house dust mite allergens
A. Rodríguez, Y. Resch, M. Curin, H. Huang, S. Banerjee, R. Valenta, S. Vrtala;
Department of Pathophysiology and Allergy Research, Division of Immunopathology, Center of Pathophysiology, Infectiology and Immunology. Medical University of Vienna, Vienna, Austria.
P.B.38.20
The particularities of ragweed pollen allergy within the sensitization patterns of patients allergic to inhaled allergens
P.B.38.21
Effectiveness of molecular diagnostics in the context of polyvalent sensitization
P.B.38.22
Changes in intestinal intraepithelial lymphocytes in an oral sensitization model in rats
P.B.38.23
Antigenspecificity in a NOD-SCID IL-Rynull mice asthma model engrafted with hPBMC
C. Panaitescu, L. Marusciac, P. T. Tamas;
University of Medicine and Pharmacy Victor Babes Timisoara, Timisoara, Romania.
M. Lomikovska, S. Zubchenko;
Lviv medical university, Lviv, Ukraine.
M. Camps-Bossacoma1,2, M. Abril-Gil1,2, M. Massot-Cladera1,2, À. Franch1,2, F. Pérez-Cano1,2, M. Castell1,2;
1
Physiology Department, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain, 2Nutrition and Food Safety Research Institute (INSA-UB), Barcelona, Spain.
M. Föhlinger1, P. Palamides2, J. Caesar2, M. Siebeck1, R. Gropp1;
1
Department of General Visceral Transplantation Vascular Thoracic Surgery, Hospital of the University of Munich, Munich, Germany, 2Veterinärwissenschaftliches Department, Gene center, Munich,
Germany.
Chairpersons: Stephen Schoenberger; La Jolla, United States / Nicola Tamassia; Verona, Italy
P.B.39.01
Assess immune-oncology profile of allograft of spontaneous mouse tumors
P.B.39.02
B cells and their chemoattractant CXCL13 in tertiary lymphoid structures formation in the anti-breast cancer immune response
H. Li, X. An, J. Liu, Z. Wang, J. Qu, J. Wery;
Crown Bioscience, Santa Clara, CA, United States.
E. Migliori, C. Gu-Trantien, S. Garaud, L. Buisseret, H. Duvillier, J. Lodewyckx, L. Van Schoonwinkel, A. Boisson, C. Naveaux, C. Solinas, P. De Silva, K. Willard-Gallo;
Institut Jules Bordet - ULB, Bruxelles, Belgium.
99
P.B.39.03
Improved systemic anti-tumor T cell responses induced by local high-dose radiotherapy in cancer patients
P.B.39.05
Bladder tumor-derived exosomes inhibited the cytotoxicity of primary natural killer cells
E. Muraro1, M. Trovò2, E. Comaro1, A. Rizzo1, F. Colizzi1, D. Martorelli1, C. Furlan2, M. Berretta3, L. Militello3, A. Del Conte4, S. Spazzapan3, E. Minatel2, R. Dolcetti1;
1
Department of Translational Research, C.R.O. National Cancer Institute, Aviano (PN), Italy, 2Department of Radiation Oncology, C.R.O. National Cancer Institute, Aviano (PN), Italy, 3Department of
Medical Oncology, C.R.O. National Cancer Institute, Aviano (PN), Italy, 4Department of Medical Oncology, Santa Maria degli Angeli Hospital, Pordenone, Italy.
Q. Li, T. Huyan, Y. wang, Q. Huang;
Key laboratory for space bioscience and space biotechnology, school of life sciences, Northwestern p, Xi’an, China.
P.B.39.06 Immunomodulatory effects of hemagglutinin-modified A20 B-cell lymphoma expanded as a brain tumor on adoptively transferred hemagglutinin-specific CD4+ T
сells
R. M. Moriev1, V. P. Shichkin1,2;
1
Research Center of Immunology and Biomedical Technologies, Open International University of Human Development “Ukraine”, Kyiv, Ukraine, 2Department of Chemical and Biomolecular Engineering,
Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States.
P.B.39.08 Malignant melanoma rejection by ICER deficient mice
T. Bohn, A. Ulges, T. Brühl, M. Klein, N. Stergiou, S. Dietzen, E. Schmitt, T. Bopp;
Institute for Immunology, Mainz, Germany.
P.B.39.09 Activation of the adaptor Stimulator of Interferon Genes (STING) attenuates anti-tumor immune responses in mice
H. Lemos, E. Mohamed, L. Huang, R. Ou, A. L. Mellor;
Georgia Regents University, Augusta, GA, United States.
P.B.39.10
Characterization of Cancer Associated Fibroblasts and the investigation of their contribution on mechanisms of immune evasion in a rat chemical breast
carcinoma model
G. Gunaydin, D. Guc;
Wednesday
P.B.39.11
Chimeric weapon: is it neoplastic Armageddon time?
P.B.39.14
LAP TGF-beta subset of CD4+CD25+CD127- Treg cells is increased and overexpresses LAP TGF-beta in lung adenocarcinoma patients
P.B.39.15
Pleural effusion CD8+ T cells from lung cancer patients express higher levels of PD-1 but do not show an exhausted phenotype
P.B.39.17
CEA-specific T cells are associated with tumour recurrence in patients with colorectal cancer
H. R. Mirzaei1, H. Mirzaei2, J. Hadjati1;
1
Deaprtment of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 2Department of Medical Biotechnology, School of Medicine, Mashhad University of
Medical Sciences, Mashhad, Iran, Islamic Republic of.
L. Islas-Vazquez, H. Prado-Garcia, D. Aguilar-Cazares, M. Meneses-Flores, M. Galicia-Velasco, S. Romero-Garcia, C. Camacho-Mendoza, J. S. Lopez-Gonzalez;
Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.
H. Prado-Garcia, S. Romero-Garcia, C. Parache-Facio, A. Osorio-Ochoa, U. Rumbo-Nava, J. Lopez-Gonzalez;
National Institute of Respiratory Diseases, Mexico City, Mexico.
D. F. Costa Bento1, M. Scurr1, C. Brown1, G. Betts2, A. Gallimore1, A. Godkin1,3;
1
Cardiff University, Cardiff, United Kingdom, 2Oxford University, Oxford, United Kingdom, 3University Hospital Wales, Cardiff, United Kingdom.
P.B.39.18 Impact of cancer senescent cells on the growth of murine tumours and anti-tumour immunity
I. Štěpánek, J. ímová, R. Mikyková, G. Michlits, M. Indrová, O. Korolov, S. Hubáčková, J. Bártek, Z. Hodný, M. Reini;
Institute of Molecular Genetics AS CR, v.v.i., Prague 4, Czech Republic.
P.B.39.19 3D coculture of cancer cells and dendritic cells in nanofibrous scaffold
T. Kim1,2, C. Kim1,3, H. Bae2, Y. Jeung4, J. Kwak1,3;
1
Immune-network Pioneer Research Center, Ajou University Medical Center, Suwon, Korea, Republic of, 2Department of Physiology, College of Medicine, Dong-A University, Busan, Korea, Republic of,
3
Department of Pharmacology, School of Medicine Ajou University, Suwon, Korea, Republic of, 4School of Mechanical Engineering, Kyungpook National University, Daegu, Korea, Republic of.
P.B.39.20
Response of monocyte - derived dendritic cells, pretreated with tissue conditioned media from colorectal carcinoma, to TLR-3 and TLR-7 agonists
S. R. Vasilijic1, M. Markovic2, D. Vucevic1, B. Bozic3, I. Rajkovic4, Z. Kostic5, S. Jankovic6, D. Mikic7, M. Colic8;
Institute for Medical Research, Faculty of Medicine of the Military Medical Academy, University of Defense in Belgrade, Belgrade, Serbia, 2Faculty of Medicine, University of Nis, Nis, Serbia, 3Faculty of
Biology, University of Belgrade, Belgrade, Serbia, 4Faculty of Medicine of the Military Medical Academy, University of Defense in Belgrade, Belgrade, Serbia, 5Clinic for General Surgery, Military Medical
Academy, Faculty of Medicine of the Military Medical Academy, University of Defense in Belgrade, Belgrade, Serbia, 6University Children’s Hospital, Belgrade, Serbia, 7Clinic for Infectious and Tropical
Diseases, Military Medical Academy, Faculty of Medicine of the Military Medical Academy, University of Defense in Belgrade, Belgrade, Serbia, 8Faculty of Medicine of the Military Medical Academy,
University of Defense in Belgrade, Faculty of Medicine, University of Nis, Belgrade, Nis, Serbia.
1
P.B.39.21
TGF-β1 polymorphisms may identify metastasis-prone patients with gastric adenocarcinoma
P.B.39.23
Sox2 communicates with Tregs through Ccl1 to promotes the stemness property of breast cancer cells
P.B.39.24
Tissue conditioned media from colorectal carcinoma stimulate in an inverse dose-dependent manner accessory capacity of human monocyte - derived dendritic
cells
I. Juarez1, A. Guitierrez2, A. Blazquez2, E. Ovejero2, I. Lasa2, A. Lopez2, R. Gomez3, J. M. Martin-Villa1;
1
Universidad Complutense de Madrid, Madrid, Spain, 2Servicio de Cirugía General y Aparato Digestivo Hospital Universitario Príncipe de Asturias, Alcala de Henares, Spain, 3Servicio de Cirugía General y
Aparato Digestivo Hospital Universitario Príncipe de Asturias, Alcala de Henarea, Spain.
Y. Xu1, Y. Ye1, X. Luo1, X. Li1, Y. Chen1, L. Wang1, Y. Liu1, P. Sun2, Y. Wei3, R. Xiang1,4,5, N. Li1,4,5;
1
School of Medicine, Nankai University, Tianjin, China, 2Departments of Cell and Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, CA, United States, 3Sichuan
University, Chengdu, Sichuan, China, 4Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Tianjin, China, 5Collaborative Innovation Center for Biotherapy, Nankai University,,
Tianjin, China.
S. Vasilijic1,2, D. Vucevic1,2, M. Markovic3, B. Bozic4, I. Rajkovic1, Z. Kostic1,5, S. Jankovic6, D. Mikic1,7, M. Colic1,3;
Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia, 2Institute for Medical Research, Military Medical Academy, Belgrade, Serbia, 3Faculty of Medicine, University
of Nis, Nis, Serbia, 4Faculty of Biology, University of Belgrade, Belgrade, Serbia, 5Clinic for General Surgery, Military Medical Academy, Belgrade, Serbia, 6University Children’s Hospital, Belgrade, Serbia,
7
Clinic for Infectious and Tropical Diseases, Military Medical Academy, Belgrade, Serbia.
1
P.B.39.25
NK cell activation mediates protection against mesothelioma in a mouse model of viral infection
M. F. Mandour, J. P. Coutelier;
Unit of Experimental Medicine, De Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
P.B.40 Myelo- and Lymphoproliferative Disorders
Chairpersons: Antoine Toubert; Paris, France / Paolo Romania; Rome, Italy (tbc)
P.B.40.01
Defective NK cells in AML patients at diagnosis are associated with blasts transcriptional signatures of immune evasion and a poor clinical outcome
P.B.40.02
Analysing pathogenic B-cell clonal dynamics
P.B.40.03
Detection of somatic calreticulin mutations in patients with essential thrombocythemia with nonmutated-JAK2
Z. Khaznadar1, S. Agaugue1, N. Boissel2, G. Henry1, M. Cheok3, J. Cayuela4, C. Preudhomme3, H. Dombret2, N. Dulphy1, A. Toubert1;
1
INSERM U1160, Université Paris Diderot Sorbonne Paris Cité; Laboratoire d’Immunologie, Hôpital Saint-Louis, AP-HP, Paris, France, 2Service d’Hématologie Adulte, Hôpital Saint-Louis, AP-HP, Université
Paris Diderot, EA3518, Paris, France, 3INSERM, UMR-837; Université de Lille, Laboratoire d’Hématologie, Centre de Biologie-Pathologie CHRU Lille, Lille, France, 4Université Paris Diderot Sorbonne Paris
Cité; Hôpital Saint-Louis, Laboratoire d’Hématologie Biologique, AP-HP, Paris, France.
R. J. Bashford-Rogers1,2, A. Palser2, P. Kelllam2,3;
1
Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 2Wellcome Trust Sanger Institute, Cambridge, United Kingdom, 3Research Department of Infection, University College
London, London, United Kingdom.
R. de la Varga Martínez1, B. Rodríguez-Bayona2, F. Mora-López1, A. Paz-Coll3;
1
Immunology Department. Hospital Universitario Puerta del Mar, Cádiz, Spain, 2Biochemistry Department. Hospital Universitario Puerta del Mar, Cádiz, Spain, 3Hematology Department. Hospital
Universitario Puerto Real, Cádiz, Spain.
P.B.40.04 Changes in AID, Dicer and Drosha mRNA Levels in Chronic Lymphocytic Leukemia Patients with Chromosomal Deletions
M. Gelmez1, E. Coskunpinar2, G. Deniz1, M. Aktan3;
1
Istanbul University, Institute of Experimental Medicine, Department of Immunology, Istanbul, Turkey, 2Istanbul University, Istanbul Faculty of Medicine, Department of Medical Genetic, Istanbul, Turkey,
3
Istanbul University, Istanbul Faculty of Medicine, Department of Hematology, Istanbul, Turkey.
100
P.B.40.05
The Role of mir-93 and mir-155 expressions in AID Regulation in Chronic Lymphocytic Leukemia
M. Gelmez1, E. Coskunpinar2, G. Deniz1, M. Aktan3;
1
Istanbul University, Institute of Experimental Medicine, Department of Immunology, Istanbul, Turkey, 2Istanbul University, Istanbul Faculty of Medicine, Department of Medical Genetic, Istanbul, Turkey,
Istanbul University, Istanbul Faculty of Medicine, Department of Hematology, Istanbul, Turkey.
3
P.B.40.06 T lymphocytes contribute to differentiation of leukemic stem cells and promote leukemia development
C. A. Ruckstuhl1, C. Riether1, A. F. Ochsenbein2;
1
Department of Clinical Research, University of Bern, Bern, Switzerland, 2Department of Medical Oncology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
P.B.40.07
Investigation of ZAP-70 expression in chronic lymphocytic leukemia patients using flow cytometry
Z. Kohl1, H. Losonczy2, T. Berki1, F. Boldizsár1;
1
University of Pécs, CC, Department of Immunology and Biotechnology, Pécs, Hungary, 2University of Pécs, CC, 1st Department of Internal Medicine, Pécs, Hungary.
P.B.40.09 HLA polymorphism in Algerian children with lymphomas
A. Galleze1, R. Raache1, H. Amroun2, N. Cherif3, F. Meçabih2, B. Mecheti2, M. Belhani3, A. Bensenouci3, M. Abbadi2, N. Attal2;
University of Sciences and Technology Houari Boumédiene, Algiers, Algeria, 2Immunology Department, Pasteur Institute of Algeria (IPA), Algiers, Algeria, 3Department of Pediatrics B, CHU Beni Messous,
Algiers, Algeria.
1
P.B.40.10
Tissue biopsies retrieved from relapsed patients with Hodgkin lymphoma are characterized by low density of CD30+ Hodgkin-Reed-Sternberg cells and low
CD30:CD68 ratio
R. Cahlikova1, V. Prochazka2, Z. Prouzova3, T. Dyskova1, T. Papajik2, E. Kriegova1;
1
Dept. of Immunology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic, 2Dept. of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech
Republic, 3Dept. of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
P.B.40.11
Contribution of serum free light chains measurement in Non Secretory Multiple Myeloma diagnosis among adult patients with hypogammaglobulinemia
P.B.40.13
CD84 regulates the interaction of CLL cells with their microenvironment and the ECM
P.B.40.14
Funtional IL7R signaling in B-cell acute lymphoblastic leukemia.
P.B.40.15
The JAK2-STAT5 pathway as a novel therapeutic target in canine mastocytoma
I. Kakkas, S. Delibasi, K. Papageorgiou, N. Harhalakis, A. Tsirogianni;
Evaggelismos General Hospital, Athens, Greece.
M. P. Kramer, A. F. Barak, I. Sagi, I. Shachar;
Weizmann Institute of Science, Rehovot, Israel.
P. Fuentes1, S. González-García1, A. Murcia1, J. Alcain1, M. Ramírez-Orellana2, M. L. Toribio1;
1
Centro de Biología Molecular “Severo Ochoa”, Madrid, Spain, 2Hospital Universitario del Niño Jesús, Madrid, Spain.
P.B.40.16 New prognostic biomarkers predicting progression in transplanted multiple myeloma patients
M. Espiño1, A. Arteche2, S. Medina1, C. Muñoz-Calleja2, M. Blanchard1, F. Lopez-Jimenez1, L. Villar1;
1
Hospital Ramón y Cajal, Madrid, Spain, 2Hospital La Princesa, Madrid, Spain.
P.B.40.18 Inhibition of BET bromodomain proteins increases NKG2D-ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in Multiple Myeloma cells: role
of cMYC/IRF4
M. Abruzzese1, C. Fionda1, A. Zingoni1, A. Soriani1, E. Vulpis1, R. Molfetta1, R. Paolini1, M. Ricciardi2, M. Petrucci2, A. Santoni1, M. Cippitelli1;
1
Dept. of Molecular Medicine, “Sapienza” University of Rome, Rome, Italy, 2Division of Hematology, Department of Cellular Biotechnologies and Hematology, “Sapienza” University of Rome, Rome, Italy.
P.B.40.19 Hematopoietic development from the Notched point of view
M. Antica1, I. Feliciello1, I. Kardum-Skelin2;
1
Ruđer Bošković Institute, Zagreb, Croatia, 2Klinicki bolnicki centar Merkur, Zagreb, Croatia.
P.B.40.20
Comparison of PIBF expression in normal peripheral blood cells and malignant haematological cell lines
P.B.40.22
Sphingosine-1-phosphate receptors are involved in cell migration in T-cell acute lymphoblastic leukemia/lymphoma
Wednesday
A. Keller1, B. Peter1,2, S. Cerny-Reiterer1,2, M. Willmann3, P. Valent1,2, E. Hadzijusufovic1,2,3;
1
Ludwig-Boltzmann-Cluster Oncology, Medical University of Vienna, Vienna, Austria, 2Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna,
Austria, 3Department of Companion Animals and Horses, Clinical Unit of Internal Medicine in Small Animals, University of Veterinary Medicine Vienna, Vienna, Austria.
G. Schilli1, B. Polgár1, G. Berta2;
1
University of Pécs, Department of Medical Microbiology and Immunology, Pécs, Hungary, 2University of Pécs, Department of Medical Biology, Pécs, Hungary.
C. V. Messias, E. Santana-van-Vliet, J. P. Lemos, V. Cotta-de-Almeida, W. Savino, D. A. Mendes-da-Cruz;
Oswaldo Cruz Institution, Rio de Janeiro, Brazil.
P.B.41 Atherosclerosis and Cardiovascular Diseases
Chairpersons: Alexander Bobik; Dingley, Australia / Georg Wick; Innsbruck, Austria
P.B.41.01
B cells are atherogenic in atherosclerosis aggravated following Myocardial Infarction.
P.B.41.02
Migration of peripheral blood mononuclear cells (PBMCs) into human healthy and diseased arteries in vitro
P.B.41.03
+3142 C>G HLA-G polymorphism as a genetic indicator for acurate cornonary artery disease
T. Kyaw1,2, P. Loveland1,2, P. Kanellakis1, A. Cao1,2, V. Deswaerte1,2, P. Tipping2, B. Toh2, A. Bobik1,3;
1
Baker IDI Heart and Diabetes Institute, Melbourne, Australia, 2Centre for Inflammatory Diseases, Medicine, Monash University, Australia, 3Immnology, Monash University, Australia.
B. Jakic1, C. Krapf2, M. Buszko1, G. Cappellano1, M. Grimm2, G. Wick1;
1
Laboratory of Autoimmunity, Division of Experimental Pathophysiology and Immunology, Biocenter, Medical University Innsbruck, Innsbruck, Austria, 2Department of Cardiac Surgery, Medical University
Innsbruck, Innsbruck, Austria.
N. Kharrat1, R. Abdelhedi2, A. Ben Hassine3, N. Abdelmouleh4, L. Abid5, A. Rebai1, I. Zidi3;
Centre de Biotechnologie de Sfax, laboratory of microorganismes and biomolecules route Sidi Mansour, Sfax, Tunisia, 2Centre de Biotechnologie de Sfax, laboratory of microorganismes and biomolecules
route Sidi Mansour, Tunis, Tunisia, 3Laboratory Microorganismes et Biomolécules Actives, Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia, 4Faculté de Médecine de Sfax, Laboratory of
Histology, Avenue Majida Bou Leila, Sfax, Tunisia, 5Hospital of Hedi chaker (CHU), Service de cardiologie, Route el Ain Km, Sfax, Tunisia.
1
P.B.41.04
An Obligatory Role for B Cells in the Development of Angiotensin II-dependent Hypertension
P.B.41.05
Increased glycolytic capacity in CD16+ monocyte subset-derived M2 macrophages is linked to foam cell formation
C. T. Christopher1, C. G. Sobey1,2, M. Lieu1, D. Ferens1, M. Kett3, H. Diep1, H. Kim1, S. M. Krishnan1, E. Salimova4, A. Vinh5, C. Samuel6, P. Tipping7, T. S. Kyaw8, B. Toh7, A. Bobik8;
1
Vascular Biology & Immunopharmacology Group, Department of Pharmacology, Monash University, Melbourne, Australia, 2Department of Surgery, School of Clinical Sciences, Monash Medical Centre,
Melbourne, Austria, 3Department of Physiology, Monash University, Melbourne, Australia, 4Rosenthal Group, Australian Regenerative Medicine Institute, Monash University, Melbourne, Australia,
5
Cardiovascular Immunology Lab, Department of Pharmacology, Monash University, Melbourne, Australia, 6Fibrosis Laboratory, Department of Pharmacology, Monash University, Melbourne, Australia,
7
Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Australia, 8Vascular Biology & Atherosclerosis Laboratory, Baker IDI Heart and
Diabetes Institute, Melbourne, Australia.
M. Lee1, A. Murphy1, K. Woollard2, D. Henstridge1, D. Sviridov1, J. Chin-Dusting1;
1
Baker IDI Heart & Diabetes Institute, Melbourne, Australia, 2Imperial College London, London, United Kingdom.
P.B.41.06 Macrovascular involvement in autoimmune patients in correlation with autoantibodies presence
K. Tziomalos1, I. Gkougkourelas2, A. Sarantopoulos2, K. Tselios2, M. Pantoura2, E. Bekiari2, A. Hatzitolios1, P. Boura2;
1
Ahepa General Hospital, Thessaloniki, Greece, 2Hippokration General Hospital, Thessaloniki, Greece.
P.B.41.07
A lipid metabolite profile in atherosclerotic plaques associated with increased inflammation and cardiovascular risk
L. Tomas1, H. Björkbacka1, A. Edsfeldt1,2, A. Danielsson1, M. Wigren1, H. Grufman1,2, A. Persson1,2, C. Prehn3, J. Adamski3,4, J. Nilsson1, I. Gonçalves1,2;
1
Department of Clinical Sciences, Lund University, Malmö, Sweden, 2Department of Cardiology, Skåne University Hospital, Malmö, Sweden, 3Institute of Experimental Genetics, Helmholtz Zentrum
München, German Research Center, Neuherberg, Germany, 4Institute of Experimental Genetics, Life and Food Science Center Weihenstephan, Technische Universität München, Freising-Weihenstephan,
Germany.
P.B.41.08 Effect of pro-inflammatory cytokines on the generation of CD4+CD28null T cells in patients with myocardial infarction
J. Bullenkamp, I. Chhetri, J. Kaski, I. E. Dumitriu;
St. George’s University of London, London, United Kingdom.
101
P.B.41.09 Interleukin-22 pathway in giant cell arteritis
S. Croci1, A. Zerbini1, F. Muratore2, L. Belloni1, F. Ciccia3, L. Boiardi2, E. Simonazzi1, A. Cavazza4, L. Cimino5, A. Moramarco5, A. Rizzo6, M. Parmeggiani1, C. Salvarani2;
1
Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy, 2Unit of Rheumatology, Arcispedale Santa Maria Nuova-IRCCS, Reggio
Emilia, Italy, 3Unit of Rheumatology,Dipartimento Biomedico di Medicina Interna e Specialistiche, Università di Palermo, Palermo, Italy, 4Unit of Pathology, Arcispedale Santa Maria Nuova-IRCCS, Reggio
Emilia, Italy, 5Unit of Ophthalmology, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy, 6Unit of Pathology, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.
P.B.41.10
Role of fractalkine receptor CX3CR1 in excess atherosclerotic inflammation in renal impairment
P.B.41.11
Atorvastatin suppresses the oxLDL-induced maturation of human dendritic cells and inhibits the subsequent T cell activation
P.B.41.12
Enhanced suppressive function of regulatory T-cells in patients with myocardial infarction
P.B.41.13
Deficiency of Siglec-G protects from metabolically-induced inflammation
S. von Vietinghoff, S. Ge, J. Nordlohne, B. Hertel, H. Haller;
A. Liu, Y. Zhang, J. Sun, J. Frostegård;
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
S. Dinkla, J. Kaski, I. Dumitriu;
St. George’s University London, London, United Kingdom.
S. Gruber1,2, T. Hendrikx1,2,3, D. Tsiantoulas1,2, M. Ozsvar-Kozma1,2, L. Göderle1,2, L. Nitschke4, R. Shiri-Sverdlov3, C. J. Binder1,2;
CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, 2Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria, 3Department of
Molecular Genetics, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, Netherlands, 4Division of Genetics, Department of Biology, University of
Erlangen–Nuremberg, Erlangen, Germany.
1
P.B.41.14
Biomarkers in human atherosclerosis: serum IL-33 as a marker of plaque stability
P.B.41.15
Advanced atherosclerosis is associated with systemic and end-organ inflammation, and vascular dysfunction but not hypertension in mice
P.B.41.16
N-Acetylcysteine protects against cardiac oxidative stress and mitochondrial dysfunction induced by isoproterenol
P.B.41.17
Pharmacological inhibition of IL-1β signalling reduces systolic blood pressure and expression of inflammatory markers in renal and vascular tissue in 1K/DOCA/salt
induced hypertension in mice
B. Ljujic1, M. Stankovic1,2, I. Tanaskovic1, S. L. Mitrovic3, N. Pejnovic1, N. Arsenijevic1, M. L. Lukic1;
1
Center for Molecular Medicine, Faculty of Medical Sciences,University of Kragujevac, Kragujevac, Serbia, 2Surgical clinic, Clinical center Kragujevac, Kragujevac, Serbia, 3Department of Pathology, Faculty
of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Q. N. Dinh, S. Chrissobolis, H. Diep, C. T. Chan, D. Ferens, G. R. Drummond, C. G. Sobey;
Monash University, Melbourne, Australia.
M. Izem, B. Djerdjouri;
University of Sciences and Technology Houari Boumediene (USTHB), Bab Ezzouar Alger., Algeria.
Y. Ling1, S. M. Krishnan1, C. T. Chan1, A. Mansell2, C. G. Sobey1, G. R. Drummond1;
1
Monash University, Melbourne, Australia, 2Monash Institute of Medical Research – Prince Henry’s Institute, Melbourne, Australia.
Wednesday
P.B.41.18
IL-25 has a protective role in experimental atherosclerosis via type 2 immune responses
P. T. Mantani1, P. Dunér1, E. Bengtsson1, A. N. McKenzie2, J. Nilsson1, H. Björkbacka1, G. Nordin Fredrikson1;
Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Malmö, Sweden, 2MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
1
P.B.41.19
Leukocyte overexpression of intracellular NAMPT attenuates atherosclerosis by regulating PPARγ-dependent monocyte differentiation and function
P.B.41.20
The role of complement properdin in fatty liver disease
P.B.41.21
Contribution of CD16-expressing monocytes to the pathophysiology of patients with MetS
B. Bermudez1, T. Dahl2, I. Medina3, P. Aukrust4, B. Halvorsen4, E. A. Biessen3;
1
Sevilla University, Sevilla, Spain, 2Oslo University, Oslo, Norway, 3Maastricht University, Maastricht, Netherlands, 4Oslo University Hospital, Oslo, Norway.
R. Kheder;
University of Leicester, Leicester, United Kingdom.
I. Sánchez-Vera1, M. C. Sádaba1, C. García de Durango1, R. Ortiz2, F. Vidal-Vanaclocha1, J. F. Varona3;
1
Universidad San Pablo CEU, Madrid, Spain, 2Hospital de Madrid, Madrid, Spain, 3Hospital de Madrid. Universidad San Pablo CEU, Madrid, Spain.
Chairpersons: Malgorzata Krzyzowska; Warsaw, Poland / Peter Openshaw; London, United Kingdom
P.B.42.01
Titers of anti-CMV antibodies reflect intensity and frequency of virus reactivations
P.B.42.02
Altered immune defense against human cytomegalovirus in APECED
P.B.42.03
Qualitative and quantitative analysis of bronchus-associated lymphoid tissue (BALT) formation on whole lung lobes by light-sheet microscopy
P.B.42.04
Monitoring of BKV-specific T-cell responses before and after kidney transplantation
I. E. Maria, M. A. Moro García, M. E. Álvarez-Argüelles, M. L. Suárez Fernández, M. Rodríguez García, R. Alonso Arias;
Hospital Central De Asturias, Oviedo-Asturias, Spain.
I. Hetemäki1, K. Hedman2,3, H. Jarva1,3, T. P. Arstila1;
1
Department of Immunology, University of Helsinki, Helsinki, Finland, 2Department of Virology, University of Helsinki, Helsinki, Finland, 3Helsinki University Central Hospital, Helsinki, Finland.
D. Mzinza, H. Fleige, R. Förster;
Institute of Immunology, Hannover Medical School, Hannover, Germany.
E. Mutlu1,2, S. Koksoy1,2, D. Mutlu3, V. Yılmaz4,2, H. Kocak4,2, A. Dinckan5,2, G. Suleymanlar4,2, M. Gultekin1;
Department of Medical Microbiology, Division of Immunology, Akdeniz University School of Medicine, Antalya, Turkey, 2Transplantation Institute, Akdeniz University Medical Faculty, Antalya, Turkey,
Department of Medical Microbiology, Akdeniz University School of Medicine, Antalya, Turkey, 4Department of Internal Medicine, Division of Nephrology, Akdeniz University School of Medicine, Antalya,
Turkey, 5Department of General Surgery, Akdeniz University School of Medicine, Antalya, Turkey.
1
3
P.B.42.05
Identification of CD4 T cell epitope in hemagglutinin stalk of pandemic H1N1 virus and characterization of its antigen-driven T-cell repertoire
I. Lu, S. Farinelle, W. J. Faison, A. Sausy, C. P. Muller;
Department of Immunology, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
P.B.42.06 IL-7 in-vitro treatment recovers HCV-specific CTL reactivity in chronic HCV infection through 4-1BB/TRAF1 co-stimulatory pathway restoration
E. Moreno-Cubero1,2, D. Subirá3, E. Sanz-de-Villalobos1, J. Míquel1, A. Lázaro4, R. Borobia1, A. González-Praetorius5, T. Parra-Cid6, J. R. Larrubia1,7;
1
Translational Hepatology Unit. Guadalajara University Hospital, Guadalajara, Spain, 2Department of Biology of Systems. University of Alcalá, Madrid, Spain, 3Hematology Service. Guadalajara University
Hospital, Guadalajara, Spain, 4Hospital Pharmacy Service. Guadalajara University Hospital, Guadalajara, Spain, 5Microbiology Service. Guadalajara University Hospital, Guadalajara, Spain, 6Clinical
Analysis Service. Guadalajara University Hospital, Guadalajara, Spain, 7Department of Medicine and Medical Specialities. University of Alcalá, Madrid, Spain.
P.B.42.07
Monitoring the Cytomegalovirus-specific cellular immunity in lung transplant recipients: A comparative analysis of two assay systems
H. Striebinger1, N. Kneidinger2, K. Böckl3, S. Barabas3, C. Neurohr2, H. Nitschko1, G. Jäger1;
1
Max von Pettenkofer-Institut, Ludwig-Maximilians-Universität München, München, Germany, 2Department of Internal Medicine V, Ludwig-Maximilians-Universität München, München, Germany, 3Lophius
Biosciences GmbH, Regensburg, Germany.
P.B.42.08 Coordinated expansion of both memory T- and NK-cells in response to CMV in human
C. Bayard1, H. Lepetitcorps1, A. Roux1, M. Larsen1, S. Fastenackels1, A. Marchant2, J. Boddaert3, F. Bajolle4, V. Appay1, D. Sauce1;
1
INSERM U1135, Cimi-Paris, Paris, France, 2Institute for Medical Immunology, Charleroi, Belgium, 3APHP, Service de Gériatrie, Paris, France, 4Hôpital Necker-Enfants malades, Paris, France.
P.B.42.09 Efficient generation of primary and memory immune responses to LCMV-WE in constitutively DC-ablated mice
C. Hilpert, S. Sitte, D. Vöhringer;
Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany.
P.B.42.10
Monocyte viability, phagocytosis and bactericidal activity in bovine-leukemia virus-infected dairy cows
M. G. Blagitz1, F. N. Souza2, C. F. Batista1, L. F. Azevedo1, E. M. Sanchez3, A. M. Della Libera1;
Faculdade de Medicina Veterinária e Zootecnia - Universidade de São Paulo, São Paulo, Brazil, 2Escola de Veterinária - Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, 3Instituto de Medicina
Tropical - Universidade de São Paulo, São Paulo, Brazil.
1
102
P.B.42.11
The correlation between disease severity and circulating levels of nitric oxide and cytokines in dengue patients
P.B.42.12
Dengue virus infection in humans elicits highly polarized cytotoxic CD4+ T cells as a function of HLA phenotype and infection history
P.B.42.13
Study of the metabolism-based mechanism for DENV-2 subversion of immune responses
P.B.42.14
Enteroviral antibodies development pecularities in patients with cardiac pathology
P.B.42.15
EBV prevalence and its impact on the B cell compartment in healthy children
P.B.42.16
Detection and characterisation of human anti-AAV CD8+ T cells using MHC class I tetramer-associated magnetic enrichment
P.B.42.17
Tumor necrosis factor-alpha blockage therapy impairs hepatitis B viral clearance and enhances T cell exhaustion in a mouse model
P.B.42.18
Hepatitis B virus causes mixed cryoglobulinemia by driving clonal expansion of innate B cells producing a VH1-69-encoded antibody
A. I. Fernandes1,2, C. M. Queiroz1,3,4, J. R. Souza1,5, F. R. Santos1, A. T. Vieira1, K. D. Amorim1, A. B. Sousa1, L. C. Alves3,4, F. A. Brayner3,4, M. T. Cordeiro3, D. N. Silva-Teixeira6, L. R. Castellano1,7;
1
Human Immunology Research and Education Group, Escola Técnica de Saúde da UFPB, Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil, 2Division of Infectious Diseases, Hospital Universitário
Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa Paraíba, Brazil, 3Centro de Pesquisas Aggeu Magalhães, CPqAM/FIOCRUZ, Recife Pernambuco, Brazil, 4Laboratory of Immunopathology
Keizo Asami, Universidade Federal de Pernambuco, Recife Pernambuco, Brazil, 5Department of Physiology and Pathology, Center for Health Sciences, Universidade Federal da Paraíba, João Pessoa Paraíba,
Brazil, 6Laboratory for Immunobiology and Cell Activation, ICS, Universidade Federal do Triângulo Mineiro, Uberaba Minas Gerais, Brazil, 7Post-graduation Program in Dental Sciences, Universidade Federal
da Paraíba, João Pessoa Paraíba, Brazil.
D. Weiskopf1, D. J. Bangs1, J. Sidney1, R. V. Kolla1, A. D. de Silva2, A. de Silva3, S. Crotty1, B. Peters1, A. Sette1;
1
La Jolla Institute for Allergy and Immunolog, La Jolla, CA, United States, 2Genetech Research Institute, Colombo, Sri Lanka, 3University of North Carolina School of Medicine, Chapel Hill, NC, United States.
M. B. M. Bertha Maximina, O. Rodriguez-Espinosa, O. Rojas-Espinosa, S. Islas-Trujillo, F. J. Sánchez-García;
Departamento de Inmunología Escuela Nacional de Ciencias Biológicas del IPN, Mexico, Mexico.
O. Prylutskyi, Y. Zhdanyuk, D. Liesnichenko;
Donetsk National Medical University, Donetsk, Ukraine.
C. Carvalho-Queiroz1, S. Saghafian-Hedengren2, I. Mayer1, B. Nussbaum1, T. Kjerstadius3, J. Persson4, M. Bemark5, C. Nilsson6,7, E. Sverremark-Ekström1;
1
Department of Molecular Biosciences, Wenner-Gren Institute (MBW), Stockholm University, Stockholm, Sweden, 2Department of Women’s and Children’s Health, Astrid Lindgren Children’s Hospital,
Karolinska University Hospital, Stockholm, Sweden, 3Department of Clinical Microbiology, Central Hospital, Karlstad, Sweden, 4Department of Mathematics, Stockholm University, Stockholm, Sweden,
5
Mucosal Immunology and Vaccine Center, Gothenburg University, Gothenburg, Sweden, 6Clinical Science and Education, Karolinska Institute, Stockholm, Sweden, 7Sachs’ Children’s and Youth Hospital,
Stockholm, Sweden.
C. Vandamme1, L. Hesnard2, M. Devaux1, N. Jaulin1, M. Guilbaud1, J. Le Duff1, M. Bonneville2, P. Moullier1, X. Saulquin2, O. Adjali1;
1
Atlantic Gene Therapies/INSERM UMR 1089, Nantes, France, 2CRCNA/INSERM UMR 892, Nantes, France.
P. Hsu, C. Sung;
Graduate Institute of Immunology, Taipei, Taiwan.
M. Del Padre1, S. Pascolini1, R. Marrapodi1, L. Todi1, M. Mitrevski1, A. De Santis2, M. Casato1, M. Fiorilli1, M. Visentini1;
Policlinico Umberto I, Department of Clinical Medicine, Division of Clinical Immunology, Rome, Italy, 2Policlinico Umberto I, Department of Clinical Medicine, Division of Gastroenterology and Hepatology,
Rome, Italy.
Chairpersons: Jorge Kalil; Sao Paulo, Brazil (tbc) / Dicle Guc; Ankara, Turkey (tbc)
P.C.17.01
12/15-lipoxygenase mediates GC-induced anti-inflammatory mechanisms in monocytes
P.C.17.02
Metallothionein regulates cadmium-induced apoptosis in macrophages
P.C.17.03
Microvesicles released by apoptotic neutrophils suppress the proliferation and IL-2/ IL-2R expression of resting T helper cells
P.C.17.04
Metal oxide nanoparticles induce conformational changes in plasma proteins and have effects on the coagulation cascade
P.C.17.06
Tannic acid, an inhibitor of calcium-activated chloride channels, blocks ATP-mediated calcium influx into T lymphocytes
P.C.17.07
CX3CR1 rupture differentially influences dopaminergic neuron degeneration in parkinsonian mice depending on the neurotoxin and its route of administration
P.C.17.08
Effects of defensin γ-thionin (Capsicum chinense) on the innate immune response of bovine mammary epithelial cells infected with Staphylococus aureus
P.C.17.09
Modulation of mRNA and miRNA expression in Leishmania-infected human phagocytes by Phlebotomus papatasi salivary gland components
Y. Kusche, J. Roth, K. Barczyk-Kahlert;
Institute of Immunology, Münster, Germany.
Wednesday
1
Y. Yoshida, T. Sugiura;
Univ.Occup.& Environ. Health, Dep. Imm., Kitakyushu, Japan.
G. Shen1, P. Schiller2, A. Nießen2, M. Schiller2, H. Lorenz2, L. Tykocinski2;
1
Division of Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2Department of Medicine V, Division of Rheumatology, University of
Heidelberg, Heidelberg, Germany.
T. Lozano Fernández1, R. Simón Vázquez1, M. Dobrovolskaia2, T. Camacho García3, Á. González Fernández1;
1
University of Vigo, Vigo, Spain, 2Nanotechnology Characterization Laboratory, Frederick, MD, United States, 3Lema&Bandín laboratory, Vigo, Spain.
S. Javed1, B. Rissiek2, S. Menzel1, G. Dubberke1, S. Adriouch3,4, F. Koch-Nolte1, F. Haag1;
1
Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 3U905,
INSERM, Rouen, France, Hamburg, Germany, 44) Institute for Research and Innovation in Biomedicine (IRIB), Normandy University, Rouen, France.
F. S. M. Tristão1,2, M. Lazzarini3, S. Martin3,4, M. Amar2, W. Stühmer3,4, F. Kirchhoff5, L. A. Gomes3, L. Lanfumey6, R. D. Prediger7, E. Del-Bel1, R. Raisman-Vozari2;
1
University of São Paulo, Ribeirão Preto, Brazil, 2Institut du Cerveau et de la Moelle Epinière, Paris, France, 3Max Planck Institute of Experimental Medicine, Göttingen, Germany, 4Center Nanoscale
Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany, 5University of Saarland, Homburg, Germany, 6Université Pierre et Marie Curie, UPMC, Paris, France, 7Universidade Federal
de Santa Catarina, UFSC, Florianópolis, Brazil.
V. Díaz, J. E. López, A. Ochoa;
Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mexico.
G. Mkannez1,2, F. Z. Guerfali1,2, R. M. Sghaier1,2, H. Attia1,2, A. Bali1,2, I. Chelbi1,2, S. Cherni1,2, E. Zhioua1,2, D. Laouini1,2;
Institut Pasteur de Tunis, Tunis-Belvedere, Tunisia, 2Université Tunis El Manar, Tunis, Tunisia.
1
P.C.17.10
Aiming for a Kill: Calcium-Dependent Initial Interaction of Perforin with the Membrane
P.C.17.11
Using FRET-based sensors to monitor ATP concentrations at the cell surface
P.C.17.12
FNDC4: a novel secreted factor with anti-inflammatory properties targeting macrophages
P.C.17.13
Anti-inflammatory effect of colonic helminth infection in mice is driven by local TGFβ1-induced epithelial repair pathways.
P.C.17.14
CD4+ T cell transmigration through hepatic epithelia induces a Th1 effector memory phenotype
P.C.17.15
Natural nitration of CXCL12 at tyrosine 7 reduces its in vitro signaling and chemotactic activity and abrogates in vivo lymphocyte migration to intra-articularly
injected CXCL12 in mice treated with the CD26 inhibitor sitagliptin
O. Naneh1, F. Merzel1, G. Anderluh1,2;
1
National Institute of Chemistry, Ljubljana, Slovenia, 2University of Ljubljana, Biotechnical faculty, Department of Biology, Ljubljana, Slovenia.
E. Schneider1, S. Menzel1, D. Plundrich1, I. M. Wolf2, F. Koch-Nolte1, F. Haag1;
1
Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical
Center Hamburg-Eppendorf, Hamburg, Germany.
M. Bosma, M. Gerling, J. Pasto, O. Shilkova, S. Almer, J. Söderman, R. Toftgård, F. Wermeling, E. Almer Boström, P. Almer Boström;
B. M. Eldakhakhny1,2, S. Levison3, L. Zeef4, P. Padfield1, J. McLaughlin1, J. Pennock1;
1
GI Sciences, Institute of Inflammation & Repair, Faculty of Medicine and Human Sciences, University of Manchester, Manchester, United Kingdom, 2King Abdulaziz University, Jeddah, Saudi Arabia,
3
Manchester Royal Infirmary, Manchester, United Kingdom, 4Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.
B. G. Wiggins1, D. Niesen2, E. Liaskou1, G. J. Webb1, S. Purswani1, S. P. Davies1, T. Bruns3, H. McGettrick1, D. H. Adams1, J. A. McKeating1, R. Thimme2, Z. Stamataki1;
1
University of Birmingham, Birmingham, United Kingdom, 2University of Freiburg, Freiburg, Germany, 3University of Jena, Jena, Germany.
R. Janssens1, A. Mortier1, D. Boff2, V. Vanheule1, S. Struyf1, J. Van Damme1, F. A. Amaral2, M. M. Teixeira2, P. Proost1;
1
Rega Institute, KU Leuven, Leuven, Belgium, 2University of Minas Gerais, Belo Horizonte, Brazil.
103
Wednesday
P.C.17.16
Caffeine and VAP-1: a potential immunomodulatory role for coffee
P.C.17.17
Mast cell-derived TNF controls neutrophil infiltration into sites of sterile inflammation
P.C.17.18
Mesenchymal stem cells lose their immunomodulatory effects upon differentiation
P.C.17.19
Regulating neutrophil response and myelopoiesis under chronic inflammatory conditions
P.C.17.21
Mesenchymal stem cells influence the ability of inflamed endothelial cells to recruit neutrophils: A comparative study
P.C.17.22
Stress induced temporary lymphocyte drop in blood during percutaneous coronary intervention
P.C.17.23
Molecular-genetic analysis of defensins in chronic periodontitis
P.C.17.24
Probiotics in Crohn disease: selecting strains able to trigger Paneth cells-derived antimicrobial response and downregulate inflammatory responses
P.C.17.25
Irisin - adipomiokine with potential anti-inflammatory properties
P.C.17.26
Modulation of NAD+ homeostasis controls TNF-α secretion in differentiated macrophages
J. R. Tickle, E. L. Shepherd, D. H. Adams, C. J. Weston;
J. Dudeck1, S. Winzer1, R. Immler2, A. Hoppe1, A. Karutz1, V. Alexaki3, S. Nedospasov4,5, S. Speier6,7,8, M. Sperandio2, T. Chavakis3, A. Dudeck1;
1
University of Technology Dresden, Medical Faculty, Institute for Immunology, Dresden, Germany, 2Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians University Munich, Germany,
München, Germany, 3University of Technology Dresden, Division for Vascular Inflammation, Diabetes and Kidney, Department of Internal Medicine, University Clinic Carl Gustav Carus, Dresden, Germany,
4
Germany German Rheumatism Research Center, Berlin, Germany, Berlin, Germany, 5Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia, Moscow, Russian
Federation, 6Paul Langerhans Institute Dresden (PLID) of Helmholtz Centre Munich at the University Clinic Carl Gustav Carus of the Technische Universität Dresden, Helmholtz Zentrum München, German
Research Center for Environmental Health, Neuherberg, Germany, Neuherberg, Germany, 7German Centre for Diabetes Research (DZD), Dresden, Germany, 8DFG-Center for Regenerative Therapies
Dresden (CRTD), Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
H. Munir, H. M. McGettrick, G. B. Nash;
Y. Liu, Z. Bian;
Georgia State University, Atlanta, GA, United States.
L. S. Clarke, H. Munir, R. Andrews, G. B. Nash, H. M. McGettrick;
E. V. Shmeleva1, S. E. Boag1, K. Bennaceur1, I. Spyridopoulos1,2,3;
1
Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 3Department of
Cardiology, Freeman Hospital, Newcastle upon Tyne, United Kingdom.
N. Sarkisjan1,2,3, I. Tuzankina2,3, M. Dolgikh1, L. Solomatina2,3;
1
USMU, Ekaterinburg, Russian Federation, 2Federal State Autonomous, Educational Institution of Higher Professional Education, Ural Federal University Named After the First President of Russia B. N.
Yeltsin, Ekaterinburg, Russian Federation, 3Institute of Immunology and Physiology of Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation.
J. Hrdy1, A. Cesaro2, C. Lapadatescu3, M. Chamaillard2, B. Pot4, C. Grangette4;
1
First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 2Récepteurs Nods-Like dans l’Infection et l’Immunité, Centre d’Infection et d’Immunité de Lille, Inserm U1019-CNRS
UMR8204, Institut Pasteur de Lille, Lille, France, 3Proxis, Bioprox, Levallois-Perret, France, 4Bactéries Lactiques et Immunité des Muqueuses, Centre d’Infection et d’Immunité de Lille, CNRS UMR8204,
Institut Pasteur de Lille, Université Lille Nord de France, Lille, France.
A. I. Mazur-Bialy1, E. Pochec2, J. Bilski1;
1
Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland, 2Jagiellonian University, Krakow, Poland.
A. Al-Shabany1, A. D. Foey2, A. J. Moody1, R. A. Billington1;
1
School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth, United Kingdom, 2School of Biomedical and Healthcare Sciences, University of Plymouth, Drake Circus, Plymouth, United
Kingdom.
Chairpersons: Carsten Watzl; Dortmund, Germany / Felix M. Wensveen; Rijeka, Croatia
P.C.18.01
IL-1β promotes in vitro UCB-derived CD34+ cell differentiation towards NK cells
P.C.18.02
Immunogenetic of NK receptors in melanoma patients
P.C.18.03
Immune profile and expression of NKG2D in chronic lymphocytic leukemia
P.C.18.04
B7-H6-mediated downregulation of NKp30 in NK cells contributes to ovarian carcinoma immune escape
P.C.18.05
Natural killer cells are indispensable for resolution of antigen-induced inflammation in mice
P.C.18.06
Phenotypic and functional stages in the intrathymic development of human NK cells
P.C.18.07
Resistance to B-RAF inhibitor confers increased immunogenicity of melanoma cells to Natural Killer cell mediated lysis
P. Ambrosini1, F. Loiacono1, R. Conte2, L. Moretta1, C. Vitale3, M. Mingari3;
1
IRCCS G.Gaslini, Genova, Italy, 2IRCCS AOU San Martino-IST, Genova, Italy, 3Università degli studi di Genova, Genova, Italy.
M. Messaoudene1, S. Rusakiewicz2, D. Enot3, L. Zitvogel2, R. Tamouza1, W. Boukouaci1, M. Avril4, A. Toubert1, A. Caignard1;
1
INSERM U1160, Paris, France, 2INSERM U1015, Villejuif, France, 3Cancer Institute Gustave Roussy, Villejuif, France, 4APHP Hospital Cochin, Paris, France.
M. Villa-Álvarez1,2, L. Huergo-Zapico1,2, A. Acebes-Huerta1,2, A. López-Soto1,2, S. Lorenzo-Herrero1,2, A. P. González-Rodríguez3, A. R. Payer3, S. Gonzalez1,2;
1
Department of Functional Biology, University of Oviedo, Oviedo, Spain, 2IUOPA, University of Oviedo, Oviedo, Spain, 3Department of Hematology, Hospital Universitario Central de Asturias, Oviedo, Spain.
S. Pesce1, G. Tabellini2, C. Cantoni1,3, O. Patrizi2, D. Coltrini2, F. Rampinelli4, J. Matta5, E. Vivier5, A. Moretta1, S. Parolini2, E. Marcenaro1;
1
Università degli Studi di Genova, Genova, Italy, 2Dipartimento di Medicina Molecolare e Traslazionale, Brescia, Italy, 3Istituto Giannina Gaslini, Genova, Italy, 4Dipartimento di Ostetricia e Ginecologia,
Spedali Civili di Brescia, Brescia, Italy, 5Centre d’Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, Marseille, France.
J. Freysdottir1,2, O. U. Anuforo1,2, H. S. Jonasdottir3, M. Giera3, I. Hardardottir2;
1
Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland, 2University of Iceland, Reykjavik, Iceland, 3Leiden University Medical Center, Leiden, Netherlands.
L. Hidalgo, V. Martínez, L. Fernández-Sevilla, R. Sacedón, A. Varas, Á. Vicente;
Department of Cell Biology, School of Medicine. Complutense University of Madrid, Madrid, Spain.
A. Frazao1, M. Colombo1, E. Neves1, F. Bouquet2, A. Savina2, M. Avril3, A. Caignard1;
1
INSERM U1160, Paris, France, 2Roche Pharmaceuticals Scientific Partnerships, Boulogne Billancourt, France, 3APHP Hospital Cochin, Paris, France.
P.C.18.08 Relationship between NKG2C copy number and different NK-cell subset redistribution patterns detected in HCMV+ individuals
A. Muntasell1, A. Pupuleku2, E. Cisneros3, A. Vera2, M. Moraru3, C. Vilches3, M. López-Botet1,2;
1
Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain, 2Pompeu Fabra University, Barcelona, Spain, 3Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
104
P.C.18.09
Analysis of memory-like NK cells in HCMV-infected pediatric patients undergoing αβ+T- and B-cell depleted HSCT for hematological malignancies
P.C.18.10
The human C-type lectin-like NK receptor NKp80 uses a distinct proximal signaling mechanism to stimulate natural killer cell activation
P.C.18.11
IL-1beta curtails NK cell stimulation by DCs and regulates CD95-induced apoptosis
P.C.18.12
Functional effects of HMGB1 released following NK/melanoma cell interaction
L. Muccio1, A. Bertaina2,3, M. Falco4, D. Pende5, R. Meazza5, M. Lopez-Botet6, L. Moretta4, F. Locatelli2,3, A. Moretta1, M. Della Chiesa1;
1
Dipartimento di Medicina Sperimentale and Centro di Eccellenza per la Ricerca Biomedica, Universita` di Genova, Genova, Italy, 2Dipartimento di Onco-Ematologia Pediatrica, Ospedale Bambino Gesu`,
Rome, Italy, 3Department of Pediatrics and Surgical Science, University of Pavia, Pavia, Italy, 4Istituto Giannina Gaslini, Genova–Quarto, Genova, Italy, 5Istituto di Ricovero e Cura a Carattere Scientifico,
Azienda Ospedaliera Universitaria San Martino-Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy, 6Universitat Pompeu Fabra and Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona,
Spain.
B. Bauer, T. Rückrich, A. Steinle;
D. M. Tufa, F. Ahmad, D. Chatterjee, G. Ahrenstorf, R. E. Schmidt, R. Jacobs;
M. Parodi1, M. Pedrazzi1, C. Cantoni1,2,3, M. Averna1,2, M. Patrone4, M. Cavaletto4, S. Spertino4, D. Pende5, M. Balsamo1, G. Pietra1,2, S. Sivori1, S. Carlomagno1, M. Mingari5,1,2, L. Moretta3, B. Sparatore1,2, M.
Vitale5;
1
Università di Genova, Genova, Italy, 2CEBR Università di Genova, Genova, Italy, 3Istituto G. Gaslini, Genova, Italy, 4University of Piemonte Orientale, Alessandria, Italy, 5IRCCS AOU S.Martino-IST, Genova,
Italy.
P.C.18.13
The alphaherpesvirus gD glycoprotein suppresses DNAM-1-dependent Natural Killer cell-mediated lysis of infected cells through modulation of CD112
P.C.18.15
Quantitative and functional deficiency of innate-memory-like CD8+ T lymphocytes in chronic myeloid leukemia patients
P.C.18.16
Catecholamine-induced alterations of cytokine secretion profiles of healthy donors’ PBMC and iNKT cells recapitulate the effects of serum from brain-injured
patients susceptible to infection
K. Grauwet1,2, C. Cantoni3,4,5, M. Parodi3, A. De Maria6,7,8, B. Devriendt2, D. Pende8, L. Moretta5, M. Vitale8, H. Favoreel2;
1
equal, contributors, Belgium, 2Laboratory of Immunology, Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium, 3Dept. of Experimental
Medicine (DIMES), University of Genova, Genova, Italy, 4equal, Contributors, Italy, 5Istituto G. Gaslini, Genova, Italy, 6Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova,
Italy, 7Dept. of Health Sciences (DISSAL), University of Genova, Genova, Italy, 8IRCCS AOU San Martino-IST, Genova, Italy.
D. Desmier1,2, F. Jacomet1,2, E. Cayssials1,2, S. Basbous1, N. Piccirilli1, A. Barra1,2, F. Guilhot1,2,3, L. Roy3, C. Giraud2, A. Herbelin1, J. Gombert1,2;
1
INSERM U1082, poitiers, France, 2CHU de Poitiers, Poitiers, France, 3CIC 802, Poitiers, France.
A. Patinec1, K. Asehnoune2, J. Rocher1, J. Le Pendu3;
1
University of Nantes, Nantes, France, 2Nantes University Hospital, Nantes, France, 3Inserm, Nantes, France.
P.C.18.17
Phenotypic and functional alterations of iNKT cells in HIV+ patients with low CD4/CD8 ratio after successful treatement
P.C.18.18
Altered phenotype and polyfunctionality of iNKT cells in different forms and treatment of multiple sclerosis
P.C.18.19
Recovery of invariant NKT cell deficiency and increase of SLAM-SAP signalling factors mRNA expression characterizes sarcoidosis remission: a 4-year longitudinal
study
D. Sara1, M. Nasi1, E. Bianchini1, M. Digaetano2, L. Gibellini1, S. Pecorini1, R. Bartolomeo1, V. Borghi2, M. Pinti1, C. Mussini1,2, A. Cossarizza1;
1
University of Modena and Reggio Emilia, Modena, Italy, 2Hospital of Modena, Modena, Italy.
D. Sara1, M. Nasi1, A. Simone2, E. Bianchini1, D. Ferraro2, F. Vitetta2, L. Gibellini1, M. Pinti1, C. Del Giovane1, P. Sola2, A. Cossarizza1;
1
University of Modena and Reggio Emilia, Modena, Italy, 2MS Center, Neurology Clinic, Nuovo Ospedale Civile Sant’Agostino Estense (NOCSAE), Modena, Italy.
M. Rijavec, K. Osolnik, P. Korošec;
P.C.18.20
The role of the transcription factor MAZR during iNKT cell development
P.C.18.21
Both positive selection and maturation of iNKT cells require natural ligand recognition
P.C.18.22
Implications of KIR/HLA-C in the presence of depression in patients with fibromyalgia syndrome
P.C.18.23
Investigating the role of c-Abl kinase in natural killer cells
C. Tizian, D. Hainberger, S. Sakaguchi, W. Ellmeier;
Institute of Immunology, Vienna, Austria.
I. Legaz Pérez1,2, G. Salgado2, E. Novoa2, J. Bolarin2, A. Mrowiec3, P. Martinez2, S. Soriano-Diaz2, A. Bernal Ramos2, A. Bermudez-Torrente4, A. Martinez-Leon5, I. Ibernon-Caballero4, M. Muro2, M. MoyaQuiles2, J. Campillo2, A. Minguela2, M. Alvarez-López2, I. Lozano6, A. Garcia-Alonso2;
1
Department of Social and Health Sciences. University of Murcia, Murcia, Spain, 2Immunology Service, Hospital Virgen de la Arrixaca, Murcia, Spain, 3Mrowiec, Murcia, Spain, 43Psychiatry DepartmentHospital Virgen de la Arrixaca, Murcia, Spain, 5Medical Family Health, San Andrés-Murcia, Murcia, Spain, 6Psychiatry Department-Hospital Virgen de la Arrixaca, Murcia, Spain.
S. Ganesan1, N. Kadri2, T. Luu Thanh2, S. Meinke2, E. Vivier3, D. Wetzel4, A. Koleske4, I. Douagi1, P. Höglund1;
1
Centre for Hematology and Regenerative Medicine (HERM), Dept. of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden, 2Centre for Hematology and Regenerative Medicine (HERM), Dept. of
Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, 3Centre d’Immunologie de Marseille-Luminy, Aix-Marseille University UM2, Inserm U1104, CNRS UMR7280, Marseille,
France, and the Assistance Publique-Hôpitaux de Marseille, Marseille, France, Marseille, France, 4Department of Pediatrics, Yale School of Medicine, Yale University, New Haven, Connecticut, USA, New
Haven, CT, United States.
Chairpersons: Dimitrios Balomenos; Madrid, Spain / Pavel Kovarik; Vienna, Austria
P.C.19.01
Knock-out of osteopontin affects the phenotype of adipose tissue macrophages but not polarization of bone marrow-derived macrophages
P.C.19.02
IL-3 synergizes with basophil-derived IL-4 and IL-13 to promote human monocyte alternative activation
P.C.19.03
CD163 Levels and Cytokine Secretion of Monocytes of in Children With Pulmonary Tuberculosis
P.C.19.05
The fate of monocytes: a tale of two viruses
P.C.19.06
Testing biocompatibility of thermo-sensitive elastin-like recombinamer (ELR) biogels for bone repair and regeneration in vivo in BALB/c mice
P.C.19.07
Novel regulation of inflammation by lysophosphatidylcholine acyltransferase (LPCAT) 3 through COX2 and PPAR-γ expression
P.C.19.08
Sustained high glucose exposure alters the phenotype and function of bone marrow derived macrophages
P.C.19.09
A murine model of sterile peritonitis
P.C.19.10
Genetically modified live attenuated L.donovani parasites induce innate immunity through classical activation of macrophages that direct Th1 response in mice
P.C.19.11
Characterization of the expression of murine CD163
P.C.19.13
Innate immune receptors of canine kupffer cells sense Leishmania infantum
P.C.19.14
Investigations of the mechanisms that regulate the differentiation of newborn monocyte under M1 and M2 polarizing conditions
P.C.19.15
Nicotinamide affects macrophage polarization
Wednesday
C. Joseph1, S. Li1, V. Olivo-pimental1, J. klibi2, A. Toubert1, K. Benlagha1;
1
inserm U1160, Paris, France, 2Pasteur institute, Paris, France.
K. Schuch1,2, K. Ambroz1, A. Castelo-Rosa1, B. Wanko2, V. Moreno-Viedma2, N. G. Sommer2, M. Zeyda2, T. M. Stulnig2;
1
FH Campus Wien, University of Applied Sciences, Department Health, Section Biomedical Science, Vienna, Austria, 2Christian Doppler Laboratory for Cardio-Metabolic Immunotherapy and Clinical Division
of Endocrinology and Metabolism, Dept. of Medicine III, Medical University of Vienna, Vienna, Austria.
F. Borriello1, M. Longo1, R. Spinelli1, A. Pecoraro1, F. Granata1, R. I. Staiano1, S. Loffredo1, G. Spadaro1, F. Beguinot1, J. T. Schroeder2, G. Marone1;
1
University of Naples Federico II, Naples, Italy, 2Johns Hopkins University, Baltimore, MD, United States.
E. Cetin Aktas1, E. Cakir2, Y. Gelmez1, A. H. Gedik2, L. Pur Ozyigit3, G. Deniz1;
1
Istanbul University, The Institute of Experimental Medicine (DETAE), Department of Immunology, İstanbul, Turkey, 2Bezmialem Vakif University Medical Faculty, Department of Pediatric Pulmonology,
Istanbul, Turkey, İstanbul, Turkey, 3Koc University, Department of Allergy and Immunology, Istanbul, Turkey, İstanbul, Turkey.
L. D. Vu, N. J. King;
University of Sydney, Sydney, Australia.
K. Changi1, B. Bosnjak1, A. Ibáñez-Fonseca2, C. Gonzalez-Obeso2, J. Rodríguez-Cabello2, M. M. Epstein1;
1
MedUniWien, Vienna, Austria, 2University of Valladolid, Valladolid, Spain.
W. Abate, C. Okorie, A. Sattar, C. O’Sullivan, S. K. Jackson;
Plymouth University, Plymouth, United Kingdom.
M. Chen, S. Pavlou, A. Stitt, H. Xu;
J. Boyken, A. Laux-Biehlmann, J. Nagel, T. Zollner, N. Schmidt;
Bayer HealthCare Pharmaceuticals GDD-GTRG-GT, Berlin, Germany.
P. Bhattacharya1, R. Dey1, P. Dagur2, M. Kruhlak2, A. Debrabant1, H. Nakhasi1;
1
Food and drug administration, Silver Spring, MD, United States, 2NIH, Bethesda, MD, United States.
L. Fischer-Riepe1, M. Wolf1, D. Holzinger1, J. Fischer2, F. Rosenbauer2, J. Roth1, K. Barczyk-Kahlert1;
1
Institute of Immunology, Muenster, Germany, 2Laboratory of Molecular Stem Cell Biology, Muenster, Germany.
A. Rodrigues1, G. Alexandre-Pires2, D. Santos-Mateus1, D. Ligeiro3, A. Valério-Bolas1, C. Martins4, M. Rafael-Fernandes1, M. Pereira1, I. Pereira da Fonseca2, G. Santos-Gomes1;
1
Unidade de Ensino e Investigação de Parasitologia Médica, Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal, 2CIISA-FCT-Faculty
of Veterinary Medicine, University of Lisbon, Lisbon, Portugal, 3IPST-Instituto Português do Sangue e da Transplantação-centro do sangue e da transplantação de Lisboa, Lisbon, Portugal, 4CEDOC, Chronic
Diseases Research Center, Immunology, NOVA Medical School, Universidade Nova de Lisboa, Portugal, Lisbon, Portugal.
A. Schneider1,2,3, M. Weier1,2,3, T. Calandra1,3, T. Roger1,3, E. Giannoni1,2,3;
1
UNIL/CHUV, Lausanne, Switzerland, 2Service of Neonatology, Departement of Pediatrics, Lausanne, Switzerland, 3Infectious Diseases Service, Departement of Medicine, Lausanne, Switzerland.
R. Weiss1,2,3, E. Schilling1,2, A. Grahnert1,2, V. Kölling1,2,3, J. Dorow4,5, U. Ceglarek4,5, U. Sack1,2, S. Hauschildt3;
1
University of Leipzig Translational Centre for Regenerative Medicine (TRM) Leipzig, Leipzig, Germany, 2University Hospital Leipzig, Institute for Clinical Immunology, Leipzig, Germany, 3University of
Leipzig, Institute of Biology, Leipzig, Germany, 4University Hospital Leipzig, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig, Germany, 5University of Leipzig, LIFE –
Leipzig Research Center for Civilization Diseases, Leipzig, Germany.
105
P.C.19.17
Monocyte chemoattractant proteins differentially affect macrophage polarization
P.C.19.19
Novel pathway that controls M1-to-M2 transition of human macrophages
P.C.19.21
The transformation effects of Polyporus polysaccharide(PPS) on polarized macrophages
P.C.19.22
CCRL2 regulates M1/M2 polarization during EAE recovery phase
C. V. Lewis, M. Canals, J. Ludeman, M. J. Stone, C. G. Sobey, G. R. Drummond, B. K. Kemp-Harper;
Monash University, Melbourne, Australia.
A. Ohradanova-Repic1, C. Machacek1, R. Platzer1, T. R. Burkard2, V. Leksa1,3, C. Charvet4,5,6, V. Feuillet4,5,6, G. J. Zlabinger7, M. B. Fischer8,9, G. Bismuth4,5,6, H. Stockinger1;
1
Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Bioinformatics Department of the Research
Institute of Molecular Pathology and the Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria, 3Institute of Molecular Biology, Slovak Academy of Sciences, Bratislava,
Slovakia, 4Institut National de la Santé et de la Recherche Médicale, INSERM U1016, Institut Cochin, Paris, France, 5Université Paris Descartes, Paris, France, 6Centre National de la Recherche Scientifique,
UMR 8104, Paris, France, 7Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 8Department of Transfusion Medicine, Medical
University of Vienna, Vienna, Austria, 9Center for Biomedical Technology, Danube University Krems, Krems, Austria.
X. Zeng;
Immunology Laboratory of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of, Guangzhou, China.
A. Del Prete1,2, C. Mazzon1,2, L. Zanotti2, L. Wang2, E. Fontana1, V. Salvi1, P. Poliani1, S. Sozzani1,2;
1
Dept. Molecular and Translational Medicine - University of Brescia, Brescia, Italy, 2Humanitas Clinical and Research Center, Rozzano (MI), Italy.
Chairpersons: Charlotte Esser; Duesseldorf, Germany / Éva Rajnavölgyi; Debrecen, Hungary
P.C.20.01
Mouse conventional dendritic cells can be universally classified based on the mutually exclusive expression of XCR1 and SIRPα
P.C.20.02
Differential modulation of inflammatory mediator production by dendritic cell subsets in an in-vitro model of red blood cell transfusion
P.C.20.03
CCR2-mediated dendritic cell recruitment by the human colon
P.C.20.04
Characterization of human afferent lymph dendritic cells from seroma fluids
S. Gurka, E. Hartung, M. Becker, R. A. Kroczek;
K. K. Ki1,2, R. L. Flower1, H. M. Faddy1,2, M. M. Dean1;
1
Australian Red Cross Blood Service, Brisbane, Australia, 2University of Queensland, Brisbane, Australia.
D. Bernardo1, L. Durant1, M. Paulsen1, R. Man2, I. Moret3, R. Vora1, D. Reddi1, G. Lee1, G. Malietzis1, Y. Siaw1, P. Hendy1, A. L. Hart2, H. O. Al-Hassi1, S. C. Knight1;
1
Imperial College London, London, United Kingdom, 2St Mark´s Hospital, London, United Kingdom, 3Hospital la Fe, Valencia, Spain.
C. De Pasquale1, B. Morandi2, I. Bonaccorsi1, P. Carrega3, C. Cantoni3, S. Ferrone4, L. Moretta3, G. Ferlazzo1;
Laboratory of Immunology and Biotherapy, Dept. Human Pathology, University of Messina, Messina, Italy, 2IRCCS A.O.U. San Martino-IST-Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy,
Istituto G. Gaslini, Genova, Italy, 4Department of Surgery, Massachusetts General Hospital, Boston, MA, United States.
1
Wednesday
106
3
P.C.20.05
Expression and functional role of murine tetraspanin-2 in dendritic cells
P.C.20.06
Notch-dependent repression of monocyte identity factor KLF4 is essential for Langerhans-type dendritic cell differentiation
P.C.20.07
An electrical engineering approach to modulate innate immunity
P.C.20.08
MyD88 signaling in CD11c+ cells controls immune responses to MCMV infection
P.C.20.09
Novel mechanisms of mesenchymal stromal cell-mediated immune suppression
P.C.20.10
Bioactive lipid Anandamide regulates maturation and function of human monocyte-derived dendritic cells
P.C.20.11
PTEN-deficiency in myeloid cells alters tumor immune surveillance in a murine model of inflammation driven colon cancer
P.C.20.12
INTERFERing with the pathogenesis of Rosacea
P.C.20.13
Role of plasmacytoid dendritic cells in the induction and regulation of anti-tumor immune responses
P.C.20.14
The role of plasmacytoid dendritic cells on Paracoccidioidomycosis infection
P.C.20.15
Fas ligation amplifies the immunosuppressive function of regulatory dendritic cells via ERK/beta-catenin pathway
P.C.20.16
The TLR7/8 agonist resiquimod ameliorates the immune response of neonatal antigen-presenting cells - possible adjuvants in neonatal vaccination
P.C.20.17
The role of plasmacytoid dendritic cells in imiquimod induced skin inflammation and melanoma clearance in mice
P.C.20.19
Role of the AP-1 protein c-Jun in Imiquimod mediated tumor clearance
C. Ruland1, J. Patzig2, K. Lahl3, V. Lukacs-Kornek4, A. Fattahi-Mehr1, A. Zimmer5, I. Förster6, T. Kuhlmann7, H. Werner2, T. Sparwasser8, S. Scheu9, J. Alferink1,10;
1
Department of Psychiatry, University Hospital Münster, Germany, Münster, Germany, 2Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany, 3National
Veterinary Institute, Technical University of Denmark, Frederiksberg, Denmark, 4Department of Medicine II, Saarland University Medical Center, Homburg, Germany, 5Institute of Molecular Psychiatry,
University of Bonn, Bonn, Germany, 6Department of Immunology and Environment, Life & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany, 7Institute of Neuropathology, University
Hospital Münster, Münster, Germany, 8Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany, 9Institute of Medical Microbiology and
Hospital Hygiene, University of Düsseldorf, Düsseldorf, Germany, 10Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany.
C. Krump1, J. Jurkin2, I. Borek1, A. Elbe-Bürger2, G. Stingl2, H. Strobl1;
1
Medical University of Graz, Graz, Austria, 2Medical University of Vienna, Vienna, Austria.
S. K. Joshi;
Frank Reidy Research Center for Bioelectrics, Norfolk, VA, United States.
M. Francozo1, F. Puttur1, G. Solmaz1, M. Lindenberg1, L. Cicin-Sain2, D. Tufa3, R. Jacobs3, T. Sparwasser1;
1
Institute of Infection Immunology, TWINCORE, Centre for Clinical and Experimental Infection Research, Hannover, Germany, 2Department of Immune Ageing and Chronic Infections, Helmholtz Centre for
Infection Research, Braunschweig, Germany, 3Clinic for Immunology and Rheumatology, Medical School Hannover, Hannover, Germany.
A. Mázló1, S. Poliska1, I. Bacskai1, N. Miltner1, Á. Apáti2, É. Rajnavölgyi1;
1
University of Debrecen, Debrecen, Hungary, 2Semmelweis University, Budapest, Hungary.
V. Chiurchiu1, E. Talamonti1, A. Leuti2, M. Maccarrone2;
1
Neurochemistry of Lipids, Santa Lucia Foundation, Rome, Italy, 2School of Medicine and Center of Integrated Research, Campus Bio-Medico University of Rome, Rome, Italy.
M. Kuttke1, E. Sahin1, J. Pisoni1, S. Percig1, A. Vogel1, D. Kraemmer1, L. Hanzl1, K. Soukup2, A. Halfmann2, A. Dohnal2, B. Hochreiter1, B. Hoesel1, J. Schmid1, G. Schabbauer1;
1
Institute for Physiology, Vienna, Austria, 2Children’s Cancer Research Institute, Vienna, Austria.
A. Mylonas1, O. Demaria1, A. Navarini2, P. Dzuniycz2, S. Meller3, M. Gilliet1, C. Conrad1;
1
Lausanne University Hospital, Lausanne, Switzerland, 2Zurich University Hospital, Zurich, Switzerland, 3Dusseldorf University Hospital, Dusseldorf, Germany.
M. Terra1,2, M. Oberkampf1,2, C. Fayolle1,2, G. Dadaglio1,2, C. Leclerc1,2;
1
Institut Pasteur, Paris, France, 2INSERM U1041, Paris, France.
F. V. Loures, E. F. Araújo, A. Condino-Neto, V. G. Calich;
Instituto de Ciências Biomédicas, São Paulo, Brazil.
C. Qian, L. Qian, Y. Yu, X. Cao;
National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China.
L. Wisgrill1, S. Schüller1, K. Sadeghi1, A. Spittler2, A. Berger1, H. Helmer3, P. Husslein3, E. Förster-Waldl1;
1
Department of Pediatrics and Adolescent Medicine, Divison of Neonatology, Medical University of Vienna, Vienna, Austria, 2Department of Surgery & CF Flow Cytometry, Medical University of Vienna,
Vienna, Austria, 3Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
G. Stulnig, B. Drobits, P. Novoszel, M. Holcmann, M. Sibilia;
Institute of Cancer Research, Vienna, Austria.
P. Novoszel, B. Drobits, G. Stulnig, M. Holcmann, M. Sibilia;
Institute of Cancer Research, Vienna, Austria.
Chairpersons: Adelheid Elbe-Bürger; Vienna, Austria / Bernhard Fleischer; Hamburg, Germany (tbc)
P.C.21.01
Segregation of the Klrd1 (CD94) mutation in DBA/2 mouse substrains
D. Shin1, A. K. Pandey2, M. K. Mulligan2, R. W. Williams2, R. Geffers3, K. Schughart1,2, E. Wilk1;
Department of Infection Genetics, Helmholtz-Zentrum für Infektionsforschung, Braunschweig, Germany, 2Center for Integrative and Translational Genomics, University of Tennessee Health Science Center,
Memphis, TN, United States, 3Research Group Genome Analytics, Helmholtz-Zentrum für Infektionsforschung, Braunschweig, Germany.
1
P.C.21.02
Inflammasome independent control of antibody responses by GPRC6A in Alum adjuvant settings
D. Quandt1, K. Rothe2, C. Baerwald2, B. Seliger1, M. Rossol2;
University of Halle, Halle, Germany, 2University of Leipzig, Leipzig, Germany.
1
P.C.21.03
Influence of KIR2DS1 in acute liver graft rejection in alcoholic cirrhosis patients with viral infection
P.C.21.04
Leishmania targets a novel Mincle/SHP-1 axis on dendritic cells to subvert adaptive immunity to infection
P.C.21.05
Inhibition of MMP-9 prevents sTREM-1 expression and sepsis during secondary bacterial pneumonia
P.C.21.06
The role of inflammasomes for Aβ microglia phagocytosis in Alzheimer’s disease
P.C.21.07
Differential peripheral immune responses mediated by Toll-like receptor ligands in amyotrophic lateral sclerosis: preclinical and clinical studies
P.C.21.08
Differential Activation of Immune Cells by Commensal versus Pathogen-derived Bacterial DNA
P.C.21.09
Schistosome-activated B cell surface Toll-like receptor-4 expression correlates with CD23 and IgM expression
P.C.21.10
Liposome encapsulation overcomes D-type and K-type CpG ODN dichotomy and induces synergistic immune activation
P.C.21.11
The capsule of cryptococcus neoformans interferes with macrophage stimulation and promotes permissiveness of intracellular infection
P.C.21.12
Enhancement of synergy between CDN and ODN by coencapsulating within pH sensitive nanoliposomes
P.C.21.13
Murine cytomegalovirus triggers interferon-β in a TLR-, RLH-, and STING-dependent manner, whereas only TLR- and RLH-dependent signaling is needed to
confer survival
I. Legaz-Pérez1, E. Navarro-Noguera2, J. Bolarin2, L. Gimeno2, G. Salgado2, A. Luna-Maldonado1, J. Campillo2, R. Moya2, M. Álvarez-López2, A. Minguela-Puras2;
1
University of Murcia, Murcia, Spain, 2Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
M. Martínez-López1, S. Iborra1, H. Izquierdo1, C. Abram2, R. Conde-Garrosa1, Y. Campos-Martín3, R. Reguera4, B. Kemp5, M. Robinson5, M. Soto6, C. Lowell2, D. Sancho1;
1
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain, 2University of California, San Francisco, CA, United States, 3Hospital Virgen de la Salud, Toledo, Spain, 4Univesidad
de León, León, Spain, 5Medimmune, Cambridge, United Kingdom, 6Centro de Biología Molecular Severo Ochoa, Madrid, Spain.
G. Weiss1, C. Lai1, B. Tildy1, R. Snelgrove1, G. Xin1, C. Lloyd1, T. Hussell1,2;
1
Imperial College London, London, United Kingdom, 2University of Manchester, Manchester, United Kingdom.
F. La Rosa1, M. Saresella1, M. Clerici1,2, M. Heneka3;
1
Don Gnocchi Foundation, Milan, Italy, 2University of Milan, Milan, Italy, 3Departiment of Neurology University of Bonn Germany, Bonn, Germany.
M. Cejudo-Guillén1,2, D. Caballero-Hernandez1,3, C. Marquez4, C. Roodveldt1, D. Pozo1,2;
1
CABIMER - Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, Spain, 2Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine. University of
Seville, Seville, Spain, 3Autonomous University of Nuevo León, Nuevo Leon, Mexico, 4Virgen del Rocío University Hospital, Seville, Spain, Seville, Spain.
D. O. Onguru1,2,3, A. V. Ofulla2, L. Ganley-Leal4, P. N. Mwinzi1;
1
Kenya Medical Research Institute, Kisumu, Kenya, 2Maseno University, Kisumu, Kenya, 3Jaramogi Oginga Odinga University of Science and Technology, Kisumu, Kenya, 4Boston University School of
Medicine, Boston, MA, United States.
B. H. Horuluoglu;
A. Tavares1, A. L. Bocca1, A. Casadeval2;
1
University of Brasilia, BRASILIA, Brazil, 2Johns Hopkins University, Baltimore, MD, United States.
B. Bayyurt, I. Gursel;
Thorlab, Molecular Biology and Genetics Department, Bilkent University, Ankara, Turkey.
Wednesday
S. Günalp, B. Toygar, B. Güngör, E. Alpdundar, M. Gürsel;
Middle East Technical University, Ankara, Turkey.
P. Tegtmeyer1, J. Spanier1, M. Döring1, C. Hirche1, S. Lienenklaus1, S. Jonjic2, U. Kalinke1;
1
Twincore GmbH, Hannover, Germany, 2Department for Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
P.C.21.14
Masked E. coli LPS is not detectable by commercially available endotoxin tests but elicits immune responses in primary human immune cells
P.C.21.15
Opportunities for Lactobacillus exopolysaccharides as immunomodulatory molecules
P.C.21.16
improved immunostimulatory activity of D-type CpG oligonucleotides encapsulated into exosomes in cancer treatment
P.C.21.17
Use of recombinant flagellin enhances hemagglutinin-specific mucosal IgA production and IL-17 secreting T cells against H5N1 avian influenza virus infection
P.C.21.18
A role for Spα in the control of infection and inflammation
P.C.21.19
Targeting of the NLRP3 inflammasome protects against pathogenic Influenza A virus
J. Gornicec, H. Schwarz, A. Duschl, J. Horejs-Hoeck;
University of Salzburg, Salzburg, Austria.
C. Allonsius, I. Claes, D. Vandenheuvel, E. Lanckacker, P. Delputte, S. Lebeer, Environmental Ecology and Applied Microbiology;
University of Antwerp, Antwerp, Belgium.
G. Gucluler1, T. Kahraman1, D. Bayik1, M. Gursel2, I. Gursel1;
1
Bilkent University, Ankara, Turkey, 2Middle East Technical University, Ankara, Turkey.
C. Lai1, N. Tang1, J. Jan2, M. Huang3, C. Lu4, B. Chiang4, L. Huang4, S. Wu1;
1
Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan, 2Genomics Research Center, Academia Sinica, Taipei, Taiwan, 3National Institute of Infectious Diseases and Vaccinology,
National Health Research Insitutes, Zhunan, Taiwan, 4Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
L. Oliveira1,2, S. Almeida1,2,3, R. F. Santos1,2, C. Bessa-Pereira1,2,4, A. M. Carmo1,2,4;
1
Cell Activation and Gene Expression Group, Instituto de Investigação e Inovação em Saúde, Porto, Portugal, 2IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal, 3Universidade de Aveiro,
Aveiro, Portugal, 4ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
A. Mansell;
MIMR-PHI Institute of Medical Research, Melbourne, Australia.
P.C.22 Complement and Fc Receptors
Chairpersons: Rudolf Oehler; Vienna, Austria / Gabriella Sarmay; Budapest, Hungary
P.C.22.01
Antigen targeting of Fc-receptors induces strong T cell responses in vivo
P.C.22.02
On the mechanism of IVIg-associated hemolysis by antibodies against A and B blood group antigens in IVIg products
P.C.22.03
Antiphospholipid Syndrome and complement activation in a transversal retrospective study
P.C.22.04
Altered B cell distribution but not CD21 phenotype in mouse models with secondary C3 deficiency
C. H. Lehmann1, A. Baranska1, K. Neubert1, M. Woigk2, D. Soulat1, A. Krug3, J. V. Ravetch4, F. Nimmerjahn2, D. Dudziak1;
1
University Hospital Erlangen, Erlangen, Germany, 2Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 3Ludwig-Maximilian Universität München, Munich, Germany, 4The Rockefeller
University, New York, NY, United States.
C. W. Bruggeman1, S. Q. Nagelkerke1, W. Lau2, T. K. van den Berg1, R. S. Yeung3, T. W. Kuijpers1,4;
1
Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, Netherlands, 2Department of Transfusion
Medicine, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, 3Department of Paediatrics, Immunology and Medical Science, Hospital for Sick Children, University of Toronto, Toronto,
ON, Canada, 4Emma Children’s Hospital, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, Netherlands.
A. Tejeda Velarde1, P. B. González Urra1, I. Gañán Nieto1, M. Núñez Beltrán2, S. Sánchez-Ramón2, Á. Carrasco Sayalero1;
1
Immunology Department. Ramón y Cajal Hospital, Madrid, Spain, 2Immunology Department. Clínico San Carlos Hospital, Madrid, Spain.
A. V. Marin1, L. Juana-López2, A. Jiménez-Reinoso1, A. C. Briones1, M. L. Gaspar3, B. de Andrés3, S. Rodríguez de Córdoba2, J. R. Regueiro1;
1
Department of Immunology, Complutense University School of Medicine and Hospital 12 de Octubre Health and Reseach Institute, Madrid, Spain, 2Centro de Investigaciones Biológicas (CSIC) and Centro
de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain, 3Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
107
P.C.22.05
Complement C3a and C5a in amniotic fluid for predicting intra-amniotic infection and spontaneous preterm delivery in women with cervical insufficiency
P.C.22.06
Reduction of complement factor H binding to CLL cells improves the induction of rituximab-mediated complement-dependent cytotoxicity
P.C.22.07
Serum-dependent processing of late apoptotic cells for enhanced efferocytosis
P.C.22.08
Complement analysis in patients with Juvenile Idiopathic Arthritis (WIELISA, SC5b9-ELISA)
P.C.22.09
TCC capacity for monitoring complement inhibition in patients with atypical hemolytic uremic syndrome treated with eculizumab
P.C.22.10
Functional differences between human CR3 (CD11b/CD18) and CR4 (CD11c/CD18): CD11b dominates iC3b mediated phagocytosis, while CD11c prevails adherence
P.C.22.11
Complement activation and regulation in pre-eclampsia
P.C.22.12
Severe congenital plasma C3 deficiency does not preclude intracellular C3 expression by singular immortalized HTLV-1 cell lines derived from two unrelated
patients’ T cells
K. Park1,2, S. Kim2, E. Jung1, S. Cho1, B. Han1, S. Park1, J. Hong1,2;
1
Seoul National University Bundang Hospital, Seongnamsi, Korea, Republic of, 2Seoul National University College of Medicine, Seoul, Korea, Republic of.
Z. Banki1, S. Hörl1, G. Huber1, A. Ejaz1, D. Windisch1, B. Muellauer1, B. Schiela1, E. Willenbacher2, M. Steurer2, H. Stoiber1;
1
Division of Virology, Medical University of Innsbruck, Innsbruck, Austria, 2Department of Internal Medicine V, Laboratory for Molecular Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Y. Y. Liang, T. Arnold, A. Michlmayr, D. Rainprecht, B. Petricevic, A. Spittler, R. Oehler;
Medizinische Universität Wien, Wien, Austria.
J. Brunner, T. Giner, L. Hackl, R. Wuerzner;
Medical University Innsbruck, Innsbruck, Austria.
M. Riedl1, J. Hofer1, T. Giner1, A. Rosales1, T. C. Jungraithmayr1, R. Würzner2;
1
Dept. of Pediatrics, Innsbruck Med. Univ., Innsbruck, Austria, 2Div. of Hyg. & Med. Microbiology, Innsbruck Med. Univ., Innsbruck, Austria.
N. Sándor1, S. Lukácsi2, R. Ungai-Salánki3, N. Orgován4, B. Szabó3, R. Horváth4, A. Erdei1,2, Z. Bajtay2;
1
Immunology Research Group of Hungarian Academy of Sciences at Eötvös Loránd University, Budapest, Hungary, 2Department of Immunology, ELTE TTK, Budapest, Hungary, 3Department of Biological
Physics, ELTE TTK, Budapest, Hungary, 4Nanobiosensorics “Lendület” Group, MTA TTK, Budapest, Hungary.
A. Lokki1,2,3, M. Siwetz4, B. Huppertz4, H. Laivuori5,2, S. Meri1,3;
1
Bacteriology and Immunology, University of Helsinki, Helsinki, Finland, 2Medical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, 3Immunobiology, Research programs
unit, University of Helsinki, Helsinki, Finland, 4Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria, 5Institute for Moleculare Medicine Finland, University of Helsinki,
Helsinki, Finland.
A. Jiménez-Reinoso1, A. V. Marin1, A. López-Lera2, S. Rodríguez de Córdoba3, E. Román-Ortiz4, M. López-Trascasa2, J. R. Regueiro1;
1
Department of Immunology, Complutense University School of Medicine and Hospital 12 de Octubre Health and Reseach Institute, Madrid, Spain, 2Immunology Unit of Hospital Universitario La Paz, Centro
de Investigación Biomédica en Red de Enfermedades Raras, IdiPAZ, Madrid, Spain, 3Centro de Investigaciones Biológicas (CSIC) and Centro de Investigación Biomédica en Red de Enfermedades Raras,
Madrid, Spain, 4Servicio de Nefrología Pediátrica, Hospital La Fe, Valencia, Spain.
Wednesday
P.C.22.13
Negative regulation of NK cell function through engagement of CR3 with its compliment ligand
P.C.22.14
ORMDL, homolog of asthma-associated ORMDL3, regulates sphingolipid biosynthesis in Drosophila melanogaster S2 cells
P.C.22.15
The long pentraxin PTX3 shapes activation of the Alternative Pathway of Complement on Aspergillus fumigatus
C. Liu1, X. Min1, N. Ma1, N. Wang1, W. Zhou2, K. Li1;
1
Core Research Laboratory, The Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong Univ, shaanxi, China, 2Medical Research Council Centre for Transplantation, King’s College London, London,
United Kingdom.
T. Paulenda, P. Dráber;
Institute of Molecular Genetics, Prague, Czech Republic.
F. Petroni1, R. Parente1, M. Sironi1, S. Valentino1, M. Gobbi2, B. Bottazzi1, A. Mantovani1,3, A. Inforzato1,4;
1
Humanitas Clinical and Research Center, Rozzano, Italy, 2Mario Negri Institute for Pharmacological Research, Milan, Italy, 3Humanitas University, Rozzano, Italy, 4Department of Medical Biotechnologies
and Translational Medicine, University of Milan, Rozzano, Italy.
Chairpersons: Raffaella Bonecchi; Rozzano, Milano, Italy / Vito Pistoia; Genoa, Italy
108
P.C.23.01
Effect of acute inflammation induced by lipopolysaccharide on Fas-mediated hepatocyte apoptosis in mice
P.C.23.02
The role of the DEAD-box helicase DDX3X in innate immune responses
P.C.23.03
Increased neutrophil infiltration, IL-1 production, and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice
P.C.23.04
Immune modulatory effects of the small peptide molecules derived from CXCL chemokines
P.C.23.05
Genetic characterization of Interleukins with relevant biological roles in lagomorphs (rabbits, hares and pikas)
P.C.23.06
Selective expression of type I IFNs by plasmacytoid DCs is sufficient to protect mice from lethal CHIKV infection
P.C.23.07
Evaluation of proinflammatory potential of lipopolysaccharide-contaminated seawater using in vitro cell-based bioassays
P.C.23.08
Role of nutritional status and metabolism on susceptibility to tuberculosis
P.C.23.09
Myeloid p38α signaling contributes to colitis-associated tumorigenesis in mice
P.C.23.10
Expansion Tregs and Inhibition Th17/Th1 by Sirolimus-based Regimen is Dependent on STAT-signaling in Renal Transplant Recipients
P.C.23.11
Salivary anti-microbial proteins and plasma cytokine changes after 3 different exercise programs in frail elderly
P.C.23.12
Local inflammatory effect induced by CcH1, a P-I metalloproteinase isolated from Cerastes cerastes venom
T. Kelava1, A. Markotic1, I. Cavar2, P. Turcic3, A. Sucur1, S. Ivcevic1, D. Flegar1, D. Grcevic1;
1
University of Zagreb, School of Medicine, Zagreb, Croatia, 2University of Mostar, School of Medicine, Mostar, Bosnia and Herzegovina, 3University of Zagreb, Faculty of Pharmacy, Zagreb, Croatia.
D. Szappanos1, R. Tschismarov1, T. Decker1, T. Perlot2, J. Penninger2, K. L. Bennett3, M. Müller4, C. Lassnig4;
1
Max F. Perutz Laboratories, University of Vienna, Vienna, Austria, 2Institute of Molecular Biotechnology, Vienna, Austria, 3Research Center of Molecular Medicine of the Austrian Academy of Sciences,
Vienna, Austria, 4University of Veterinary Medicine Vienna, Vienna, Austria.
H. Tsai1,2;
1
Graduate Intitute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan, 2Department of Internal Medicine, Taipei Medical University Shuang Ho Hospita, Taipei, Taiwan.
D. Yoyen-Ermis, P. Karasar, G. Esendagli;
F. Neves1,2, J. Abrantes1, T. Almeida1, A. L. de Matos3, P. P. Costa2,4, P. J. Esteves1,5,6;
1
CIBIO - Centro de Investigação em Biodiversidade e Recursos Genéticos, Vairão, Vila do Conde, Portugal, 2UMIB/UP – Unidade Multidisciplinar de Investigação Biomédica/Universidade do Porto, Porto,
Portugal, 3Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, United States, 4Dpt. Genética, CSPGF, Instituto Nacional de Saúde Dr. Ricardo Jorge,
Porto, Portugal, 5Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal, 6CITS - Centro de Investigação em Tecnologias de Saúde, CESPU, Gandra, Portugal.
S. W. Werneke1,2, B. Zafirova1,2, M. L. Albert1,2;
1
Institut Pasteur, Paris, France, 2INSERM, Paris, France.
A. A. Sattar, W. Abate, G. Bradley, G. Fejer, S. K. Jackson;
Centre for Biomedical Research, Plymouth University Schools of Medicine and Dentistry, Plymouth, United Kingdom.
C. La Rocca1, C. Palma2, V. Gigantino1,3, F. Perna4, G. Matarese5,6;
1
Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli, Italy, 2Dipartimento di malattie infettive,parassitarie ed immunomediate, Istituto Superiore
di Sanità, Roma, Italy, 3Unità di patologia, istituto nazionale tumori di Napoli, Naples, Italy, 4Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, Napoli, Italy, 5Dipartimento di
Medicina e Chirurgia, Università di Salerno, Baronissi Campus, Salerno, Italy, 6IRCCS Multimedica, Milano, Italy.
C. Youssif, A. R. Nebreda;
IRB (Institue for Research in Biomedicine) Barcelona, Barcelona, Spain.
Y. Li1, Y. Shi2, l. luo2, j. chen2;
1
Department of Clinical Immunological Laboratory, West China Hospital, Sichuan University, Chengdu, China, 2Department of Clinical Immunological Laboratory, West China Hospital, Sichuan University,
chengdu, China.
A. M. Teixeira, M. U. Chupel, G. Furtado, A. F. Pedrosa, M. F. Rosado, J. P. Ferreira, L. Rama;
Coimbra University, Faculty of Sport Sciences and Physical Education, Coimbra, Portugal.
H. Boukhalfa-Abib, F. Laraba-Djebari;
USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology,, Bab ezzouar, Algiers, Algeria.
P.C.23.13
Dynamics of TNF inhibitor mediated regulation of IL-10 expression by human T cells
P.C.23.14
Tyrosine kinase 2 (Tyk2) deficiency or inactivation of its enzymatic activity protects against LPS-induced sepsis
P.C.23.15
The proteins of human serum γ-globulin fraction transformed with metal ions chelating inhibit production of growth factors and chemokines
P.C.23.16
The proteins of human serum γ-globulin fraction transformed with metal ions chelating promote Th1/Th2 shifts in immune regulation
P.C.23.17
Dual function of Interleukin-33 on Human gastric adenocarcinoma cells (AGS) and Human gastric epithelial cells (GES-1)
P.C.23.18
IL-33 expressing resident cells in lung homeostasis and upon infection
P.C.23.19
mRNA expressions of cytokines by rhinovirus infection in human keratinocyte cell lines
L. E. Durham1,2, C. A. Roberts2, B. W. Kirkham1, L. S. Taams2;
1
Guys and St Thomas’ NHS Foundation Trust, London, United Kingdom, 2King’s College London, London, United Kingdom.
A. Poelzl1, M. Prchal-Murphy2, C. Lassnig1,3, R. Rom1, M. Mueller1,3, B. Strobl1;
1
Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria, 2Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria, 3Biomodels
Austria, University of Veterinary Medicine, Vienna, Austria.
M. Apresova, A. Mezdrokhina, A. Babajanz, S. Cheknev;
The Federal State N.F.Gamaleya Research Centre for Epidemiology and Microbiology, Moscow, Russian Federation.
S. Cheknev, M. Apresova, I. Efremova, A. Mezdrokhina, A. Babajanz;
The Federal State N.F.Gamaleya Research Centre for Epidemiology and Microbiology, Moscow, Russian Federation.
L. F. Pisani1, N. Munizio1, P. Creo1, V. Bronzo2, M. Vecchi1,2, L. Pastorelli1,2;
1
IRCCS Policlinico San Donato, San Donato Milanese, Italy, 2University of Milan, Milan, Italy.
J. H. Fritz, C. U. Duerr;
McGill University, Montreal, QC, Canada.
S. Kang1,2,3, K. Sohn1,2,3, S. Kim3, S. Kim1,2,3, J. Yu4, Y. Chang1,2,3;
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, Republic of, 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul,
Korea, Republic of, 3Biomedical Research Institutue, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea, Republic of, 4Department of Pediatrics, Asan Medical Center, University of
Ulsan College of Medicine, Seoul, Korea, Republic of.
1
P.C.23.20
Mucosal Immune response in young soccer players during a regular in-season training week
P.C.23.21
Development and analytical validation of a flexible multiplexing platform for cytokine assays
L. G. Minuzzi, L. M. Rama, A. B. Teixeira, R. F. Lopes;
University of Coimbra, Coimbra, Portugal.
P.C.24 microRNAs and Epigenetics
Chairpersons: Massimo Locati; Milan, Italy / Markus Feuerer; Heidelberg, Germany
P.C.24.01
Liquid biopsies as tool for prognostic/predictive biomarker discovery in Breast Cancer patients
P.C.24.02
Reduced expression of let-7a in bronchial biopsies of severe asthmatics
P.C.24.03
MicroRNAs calibrate the immune response in Mycobacterium tuberculosis infection
P.C.24.04
MicroRNA-200b represses TGF-β1 induced epithelial-mesenchymal transition in immortalized primary human epithelial cells (BEAS-2B)
P.C.24.05
Intercellular transfer of microRNA between regulatory T cells and dendritic cells: a possible mechanism of regulation of dendritic cell function
P.C.24.06
Targeting microRNAs in plasmatocytoid DCs to predict and cease systemic sclerosis development
P.C.24.07
Optimizing the purification and analysis of miRNAs and mRNAs from RIP in primary human neutrophils
P.C.24.08
Progressing sarcoidosis is associated with altered miRNA profile in bronchoalveolar (BAL) cells obtained from sarcoidosis patients
P.C.24.09
DNA methylation dynamics regulating mast cells in health and disease
P.C.24.10
The histone deacetylase HDAC1 expression in human periodontitis - preliminary results
P.C.24.11
Enhanced H3K27 acetylation by HDAC8 inhibition prevents anthrax lethal toxin-induced immune suppression in macrophages
P.C.24.12
Epigenetic regulation of cytokine production in endotoxin tolerance
P.C.24.13
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection
P.C.24.14
Identification and characterization of long noncoding RNAs in primary human monocytes and neutrophils
S. P. Fortis1, L. Mahaira1, N. Anastasopoulos1, C. Haritos1, M. Sofopoulos2, E. Iliopoulou1, I. Kalogeropoulou1, S. A. Perez1, C. N. Baxevanis1;
1
Cancer Immunology and Immunotherapy Center, Saint Savas Cancer Hospital, Athens, Greece, 2Saint Savas Cancer Hospital, Pathology Department, Athens, Greece.
M. Rijavec, P. Korošec, M. avbi, I. Kern, M. Marc Malovrh;
J. Basu;
Bose Institute, Department of Chemistry, Kolkata, India.
Wednesday
P. Liu, Q. Ning, S. Rangwala, C. Shelburne, L. Kobayashi, C. Lu, D. Stewart, M. Tsionsky, T. Plisova, E. N. Glezer, P. Oberoi, J. N. Wohlstadter;
S. S. Ladak, C. Ward, S. Ali;
Newcastle University, Newcastle Upon Tyne, United Kingdom.
L. A. Smyth1, S. Tung1, M. Letizia1, D. Boardman1, L. Dioni2, V. Bollati2, R. Lechler1, G. Lombardi1;
1
King’s College London, London, United Kingdom, 2Università degli Studi di Milano, Milan, Italy.
M. Rossato1, E. Chouri1, M. Cossu1, K. Nikitopoulou1, J. Drylewicz1, L. van Bon1, R. Wichers1, C. Bekker1, J. A. Borghans1, L. Beretta2, T. R. Radstake1;
1
UMC Utrecht, Utrecht, Netherlands, 2Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.
S. Ghasemi, M. Castellucci, S. Gasperini, B. Mariotti, N. Tamassia, F. Bazzoni;
Department of Pathology and Diagnostics, Division of General Pathology, University of Verona, Verona, Italy.
T. Dyskova1, R. Fillerova1, T. Novosad2, S. B. Tiscordio2, M. Zurkova3, V. Kolek3, E. Kriegova1;
1
Dept. of Immunology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic, 2Dept. of Computer Science, VSB - Technical University, Ostrava, Czech Republic, 3Dept. of
Respiratory Diseases, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
L. Cristina1,2, S. Montagner1,2, S. Monticelli1;
1
Institue for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland, 2Graduate School for Cellular and Biomedical Sciences, University of Bern, Switzerland.
A. C. Morandini1, E. J. Franco2, E. S. Ramos-Junior3, A. A. Pedra1, F. B. Andrade4, C. F. Santos1;
1
University of São Paulo - Department of Biological Sciences, Bauru School of Dentistry, Bauru, Brazil, 2Catholic University of Brasília - Department of Periodontology, School of Dentistry, Brasília, Brazil,
3
University of São Paulo - Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, Ribeirão Preto, Brazil, 4University of São Paulo - Department of Endodontics, Bauru
School of Dentistry, Bauru, Brazil.
S. KIM, S. Ha;
University of Western Ontario, London, ON, Canada.
C. Reschke1, C. Walter2, P. Hansen3,4, D. M. Ibrahim3,5, J. Fischer6, J. Hecht3,5, H. Volk1, G. Grütz1;
1
Charite - Institute for Medical Immunology, Berlin, Germany, 2Institute of Medical Informatics, Medical Faculty of the WWU Münster, Münster, Germany, 3Berlin-Brandenburg Center for Regenerative
Therapies (BCRT), Berlin, Germany, 4Charité - Institute for Medical and Human Genetics, Berlin, Germany, 5Max Planck Institute for Molecular Genetics, Berlin, Germany, 6Institute of Molecular Tumor
Biology, Medical Faculty of the WWU Münster, Münster, Germany.
C. Schliehe1, E. K. Flynn2,3, B. Vilagos1, U. Richson1, S. Swaminathan4, B. Bosnjak5, L. Bauer1, R. K. Kandasamy1, L. J. Kosack1, I. M. Griesshammer1, F. Schmitz4, V. Litvak6, J. Sissons4, A. Lercher1, A.
Bhattacharya1, K. Khamina1, A. L. Trivett2, L. Tessarollo2, I. Mesteri7, A. Hladik1,8, D. Merkler9,10, S. Kubicek1, S. Knapp1,8, M. M. Epstein5, D. E. Symer2, A. Aderem4, A. Bergthaler1;
1
CeMM - Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, 2Center for Cancer Research, National Cancer Institute, Frederick, MD, United States, 3GeneDx,
Gaithersburg, MD, United States, 4Seattle Biomedical Research Institute, Seattle, WA, United States, 5Department of Dermatology, DIAID, Experimental Allergy, Medical University of Vienna, Vienna,
Austria, 6University of Massachusetts, Worcester, MA, United States, 7Department of Pathology, Medical University of Vienna, Vienna, Austria, 8Department of Medicine 1, Medical University of Vienna,,
Vienna, Austria, 9Department of Pathology and Immunology, Division of Clinical Pathology, University & University Hospital of Geneva, Geneva, Switzerland, 10Department of Neuropathology, GeorgAugust-University Goettingen, Goettingen, Germany.
B. Mariotti1, F. Bianchetto1, N. Tamassia1, M. Rossato2, M. Castellucci1, R. Ostuni3, M. A. Cassatella1, F. Bazzoni1;
Department of Pathology and Diagnostic, Division of General Pathology, University of Verona, Verona, Italy, 2Department of Rheumatology and Clinical Immunology, UMC, Utrecht, Netherlands,
Department of Experimental Oncology, IEO, Milan, Italy.
1
3
109
P.C.24.15
Genome-wide patterns of PU.1 and H3K4me1 localization in human neutrophils and monocytes
P.C.24.16
Dectin-1 is critical for miR155 up regulation in murine macrophages invaded by Candida albicans hyphae
F. Bianchetto1, N. Tamassia1, M. Zimmermann1, G. Natoli2, M. A. Cassatella1;
1
Department of Pathology and Diagnostics, Division of General Pathology, University of Verona, Verona, Italy, 2Department of Experimental Oncology, European Institute of Oncology (IEO), Milan, Italy.
D. P. Agustinho1, M. Oliveira1, A. H. Tavares1, L. Derengowski1, V. Stolz2, M. R. Mortari1, K. Kuchler2, I. Silva-Pereira1;
University of Brasilia, Brasilia, Brazil, 2Max F. Perutz Laboratories, Vienna, Austria.
1
P.C.24.17
MicroRNA-150 regulates the cytotoxicity of natural killers by targeting perforin-1
T. Kim1,2, N. Kim1, I. Choi1,2;
1
Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea, Republic of, 2Korea University of Science and Technology (UST), Daejeon, Korea, Republic of.
P.D.19 Vaccines for Infectious Diseases
Chairpersons: Birgit Weinberger; Innsbruck, Austria / Reinhard Würzner; Innsbruck, Austria (tbc)
P.D.19.01 A comprehensive analysis of LACK (Leishmania homologue of receptors for activated C kinase) in the context of Visceral Leishmaniasis
S. Sinha, S. Sundaram, A. Kumar;
Centre for Biotechnology, University of Allahabad, Allahabad, India.
P.D.19.02 Development of a dual protective mucosal vaccine against botulism and influenza
M. Zeng, J. Li, D. Diaz-Arévalo, Y. Chen;
Texas Tech University Health Sciences Center, El Paso, TX, United States.
P.D.19.03
Marginal role of phosphorylations on CMV tegument phosphoproteins
F. J. J. Rieder1, M. Kastner1, W. J. Britt2, K. Djinovic-Carugo3, C. Steininger1;
1
Medical University of Vienna, Clinic of Internal Medicine I, Department of Infectious Diseases and T, Vienna, Austria, 2Department of Pediatrics, Children’s Hospital, Birmingham, AL, United States,
3
Department of Structural & Computational Biology, Max F. Perutz Laboratories, Vienna, Austria.
P.D.19.04 DNA motif immunization
X. Wu;
The University of Hong Kong, Hong Kong, Hong Kong.
P.D.19.05 Restricted antibody response to Bordetella pertussis filamentous hemagglutinin induced by whole-cell and acellular pertussis vaccines
Wednesday
H. Asgarian-Omran1,2, M. Golara2, S. Abdolmaleki2, S. S. Navabi2, H. Alipour3, J. Khoshnoodi2, A. Hemmati4, S. Zarei4, M. Jeddi-Tehrani4, F. Shokri2,4;
1
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences,, Sari, Iran, Islamic Republic of, 2Department of Immunology, School of Public Health, Tehran University of
Medical Sciences, Tehran, Iran, Tehran, Iran, Islamic Republic of, 3Department of Agronomy and Plant Breeding, Campus of Agriculture and Natural Resource, Tehran University, Karaj, Iran, Karaj, Iran,
Islamic Republic of, 4Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran, Islamic Republic of.
P.D.19.06 Eucaryotic Expression of HSV Glycoproteins gC2, gD1, gD2 and Immunogenicity Analysis
Y. Li1, S. Li1,2, Y. Qi1, T. Xu1, T. Xu1, J. Zhou1, Y. Pan1, S. Li1;
1
Huadong Research Institute for Medicine and Biotechniques, Nanjing, China, 2School of Basic Medicine, Nanjing Medical University, Nanjing, China.
P.D.19.07 Employing improved antigens allows streamlining of heterologous DNA-prime and NYVAC/protein-boost HIV vaccine regimens in rhesus macaques
B. Asbach1, A. Kliche1, J. Köstler1, B. Perdiguero2, M. Esteban2, B. Jacobs3, D. Montefiori4, C. Labranche4, N. L. Yates4, G. D. Tomaras4, G. Ferrari4, K. Foulds5, M. Roederer6, N. Hawkins6, S. Self6, S. Phogat7, J.
Tartaglia7, S. W. Barnett8, B. Burke8, A. Cristillo9, J. Francis9, S. Ding10, J. L. Heeney11, G. Pantaleo12, R. Wagner1;
1
Institute of Medical Microbiology and Hygiene, Universität Regensburg, Regensburg, Germany, 2Centro Nacional de Biotecnología, Madrid, Spain, 3The Biodesign Institute at Arizona State University,
Tempe, AZ, United States, 4Duke University, Durham, NC, United States, 5Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH),
Bethesda, MD, United States, 6Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, United States, 7Sanofi Pasteur, Swift Water, PA, United
States, 8Novartis Vaccines and Diagnostics, Inc., Cambridge, MA, United States, 9Advanced BioScience Laboratories, Inc., Kensington, MD, United States, 10EuroVacc Foundation, Lausanne, Switzerland,
11
Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom, 12Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier
Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
P.D.19.09 Induction of immune response in mice after injection of mesenchymal stem cells transfected with gD gene of herpes simplex virus
A. Murzakova, R. Klimova, A. Kushch;
Federal Research Centre of Epidemiology and Microbiology named after the academician N. F. Gamaleya, Moscow, Russian Federation.
P.D.19.10 Efficacy of Flu SAM® (HA) vaccine against Influenza infection in mice and ferrets
M. Brazzoli1, D. Magini1, A. Bonci1, S. Buccato1, V. Zurli1, S. Mangiavacchi1, D. Casini1, R. Kratzer2, L. A. Brito3, E. De Gregorio1, P. W. Mason4, J. B. Ulmer3, A. J. Geall5, S. C. Bertholet1;
1
GSK, Siena, Italy, 2Transgene, Lyon, France, 3GSK, Cambridge, MA, United States, 4Regeneron Pharmaceuticals, Tarrytown, NY, United States, 5Avidity NanoMedicines, La Jolla, CA, United States.
P.D.19.11
Specificities of human CD4+ T cell responses to the live attenuated yellow fever virus vaccine (17D-204)
M. Koblischke1, I. Fae2, G. Fischer2, M. Mackroth3, B. Fleischer3, K. Stiasny1, F. X. Heinz1, J. H. Aberle1;
1
Department of Virology, Medical University of Vienna, Vienna, Austria, 2Department for Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria, 3Department of
Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
P.D.19.12 New approaches to localize protective CD8 T-cell responses in liver stage malaria
A. Gola1, A. A. Walters1, B. R. Halbroth1, A. Salman1, S. M. Khan2, C. J. Janse2, A. J. Spencer1, A. V. Hill1;
University of Oxford, Jenner Institute, Oxford, United Kingdom, 2Leiden University, Medical Center, Leiden, Netherlands.
1
P.D.19.13
Longitudinal analysis of antibody responses following vaccination against group B meningococcus (MenB) and the impact on their functional activity
A. Mariani, M. Bruttini, V. Masignani, G. Del Giudice, O. Finco, E. Bartolini, F. Buricchi;
GSK Vaccines, Siena, Italy.
P.D.19.14 Enhanced protection of human PD1-based HIV-1 mosaic DNA vaccine
S. M. Chen, J. Tang, X. Wu, Z. Chen;
The University of Hong Kong, Hong Kong SAR, Hong Kong.
P.D.19.15
The development of a protein-based vaccine against Buruli ulcer
K. M. Mangas1, E. Marion2,3, L. Marsollier2,3, B. Y. Chua1, N. J. Tobias1, D. C. Jackson1, T. P. Stinear1;
1
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia, 2ATOMycA, Inserm Avenir Team, CRCNA, Inserm U892, 6299 CNRS Angers, Angers, France, 3LUNAM,
Université d’Angers, Angers, France.
P.D.19.16 A gold glyco-nanoparticle carrying a listeriolysin O peptide and formulated with advax™ delta inulin adjuvant induces robust t-cell protection against listeria
infection
C. Alvarez-Dominguez1, R. calderon-gonzalez1, L. Alaez-Alvarez1, S. Penades2, N. Petrovsky3;
1
Instituto de Formacion e Investigación Marques de Valdecilla, Santander, Spain, 2CIC-biomaGUNE, San Sebastian, Spain, 3Flinders University, Adelaide, Australia.
P.D.19.17
Schistosoma mansoni tegument protein Sm29 elicits robust immunogenicity in the baboon model
P. Ogongo;
Institute of Primate Research, Nairobi, Kenya.
P.D.19.18 sero Surveillance of Measles virus among-st vaccinated children of rural population of Pakistan
Z. Hussain, M. Qureshi, S. Sharafat;
Dow University of Health Sciences, Karachi, Pakistan.
P.D.19.19 Dengue neutralizing antibody responses in mice receiving heterologous prime/boost of tetravalent live-attenuated and DNA vaccines
E. Prompetchara1, C. Ketloy1,2, P. Keelapang3, R. Sriburi3, N. Sittisombut3,4, K. Ruxrungtham1,5;
1
Dengue Vaccine Research Unit, ChulaVRC, Chulalongkorn University, Bangkok, Thailand, 2Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand,
3
Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 4Medical Biotechnology Research Unit, National Center for Genetic Engineering and Biotechnology, National
Science and Technology Development Agency, Bangkok, Thailand, 5Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
P.D.19.20 Competition of adenovirus epitopes with transgene epitopes - investigation of particular mechanisms of immonusuppression in adenovirus pre-immune mice
C. Hrycak, D. Schöne, S. Windmann, W. Bayer, U. Dittmer;
Institute for Virology University Hospital Essen, Essen, Germany.
110
P.D.19.21 Balance between activation and regulation of HIV-specific CD8 T cells response after MVA-B therapeutic vaccination
N. I. Rallón1,2, B. Mothe3, J. C. Lopez Bernaldo de Quiros4, M. Plana5, J. M. Ligos6, M. Montoya6, M. A. Muñoz4, M. Esteban7, F. García5, C. Brander3,8, J. M. Benito1,2;
1
IIS-Fundación Jiménez Díaz, UAM, Madrid, Spain, 2Hospital Universitario Rey Juan Carlos, Móstoles, Spain, 3IrsiCaixa/HIVCAT, Barcelona, Spain, 4Hospital General Universitario Gregorio Marañón, Madrid,
Spain, 5Hospital Clinic, Barcelona, Spain, 6Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain, 7Centro Nacional de Biotecnología, Madrid, Spain, 8Institució Catalana per la Recerca i
Estudis Avancats (ICREA), Barcelona, Spain.
P.D.19.22
Antibody and plasmablast response to 13-valent pneumococcal conjugate vaccine in patients with chronic kidney disease
E. Grywalska1, W. Zaluska2, I. Smarz-Widelska3, D. Niespodziewańska-Mierzyńska3, M. Zgurski1, J. Drabik4, J. Rolinski1;
Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland, 2Department of Nephrology, Medical University of Lublin, Lublin, Poland, 3Department of
Nephrology, Lublin, Poland, 4Department of Nephrology, Lubartow, Poland.
1
P.D.19.23
Importance of the pentameric complex in vaccine development against cytomegalovirus
Y. Choi, A. McGregor;
Texas A&M Health Science Center, College Station, TX, United States.
P.D.20 Vaccine Adjuvants
Chairpersons: África González-Fernández; Vigo, Spain / Franz X. Heinz; Vienna, Austria
P.D.20.01
Adjuvant effect of Propionibacterium acnes on the immunogenicity of a CD4+ epitope-based HIV vaccine
P.D.20.02
Cholesterol-coupling of dsRNA serves as a potent adjuvant delivery system
P.D.20.03
Increasing influenza vaccine efficacy through the use of inflammasome targeting adjuvants
D. Teixeira1, J. S. Apostólico1, J. M. Viel1, V. C. Passarelli1, M. E. Ishimura1, G. P. Silveira1, M. Gambero1, E. Cunha-Neto2, D. S. Rosa1, I. M. Longo-Maugéri1;
1
Federal University of São Paulo, São Paulo, Brazil, 2University of São Paulo-School of Medicine, São Paulo, Brazil.
H. Obermann, I. Lederbogen, A. Kaufmann, S. Bauer;
Institute for Immunology, Marburg, Germany.
R. F. Russell, J. U. McDonald, J. S. Tregoning;
P.D.20.04 The vaccine adjuvant alum inhibits Th1 responses by promoting the induction of interleukin-10
E. Oleszycka, S. McCluskey, F. A. Sharp, E. C. Lavelle;
Trinity Biomedical Sciences Institute, Dublin, Ireland.
Adjuvant effect of killed-Propionibacterium acnes on immunogenicity of the dendritic-tumor cells hybrid vaccine
M. E. Ishimura, D. Teixeira, G. P. Silveira, M. Gambero, G. A. Colozza Gama, B. S. Ozane Pimenta, I. M. Longo-Maugéri;
Federal University of São Paulo, São Paulo, Brazil.
P.D.20.06 Effect of recombinant Leishmania major lipophosphoglycan 3 (LPG3) on human B-cells activation and cytokine secretion
M. Haji-Fatahaliha1, M. Hosseini1, S. Rasoulzadeh1, M. Ghafari-Khamene2, M. Shabani3, J. Majidi1, M. Yousefi1;
1
Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of, 2Islamic Azad University, Urmia, Iran, Islamic Republic of, 3Avicenna Research Institute, Tehran, Iran, Islamic Republic of.
P.D.20.07
CpG ODN/cationic peptide nanorings as anti-viral and anti-tumor agents
B. Gungor1, M. Gursel1, &. Gursel2, G. Tincer Konig2, F. C. Yagci2;
1
Middle East Technical University, Ankara, Turkey, 2Bilkent University, Ankara, Turkey.
P.D.20.08 Combined use of CpG ODN and CDNs promote synergistic activation in immune cells
S. Yildiz1, E. Alpdundar1, B. Gungor1, T. Kahraman2, B. Bayyurt2, I. Gursel2, M. Gursel1;
1
Middle East Technical University, Ankara, Turkey, 2Bilkent University, Ankara, Turkey.
P.D.20.09 Intramuscular vaccination together with RNAdjuvant® induces local effects that enhance immune responses in a TLR- and RLH-dependent manner
A. Kessler1, C. Soldner1,2, S. Lienenklaus3,4,1, J. Spanier1, T. Kramps5, K. Kallen6, R. Heidenreich6, M. Fotin-Mleczek6, U. Kalinke1;
1
Twincore, Centre for Experimental and Clinical Infection Research GmbH, Hannover, Germany, 2Vakzine Projekt Management GmbH, Hannover, Austria, 3Molecular Immunology, Helmholtz Centre for
Infection Research, Braunschweig, Germany, 4nstitute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany, 5Boehringer Ingelheim Pharma GmbH &
Co. KG, Ingelheim, Germany, 6CureVac GmbH, Tübingen, Germany.
P.D.20.10
The impact of different influenza vaccines on viral-bacterial co-infection in the mouse model
P.D.20.11
Signaling molecules of the innate immune system as genetic adjuvants in DNA immunizations against Influenza A viruses
P.D.20.12
The effect of recombinant Leishmania major lipophosphoglycan 3 (LPG3) on purified human T lymphocytes
P.D.20.13
Impaired post vaccination influenza-specific humoral immune responses in mice genetically predisposed to metabolic dysfunction can be partially restored by
adjuvantation
Wednesday
P.D.20.05
V. Zurli1,2, M. Gallotta3, M. Taccone1, E. Chiarot1, M. Brazzoli1, E. De Gregorio1, S. Bertholet1, B. Baudner1, A. Seubert1;
1
GSK Vaccines, Siena, Italy, 2University of Padua, Padua, Italy, 3Dynavax, Berkeley, CA, United States.
D. Lapuente1, V. Stab1, A. Maaske1, C. Ehrhardt2, D. Hannaman3, M. Tenbusch1;
1
Ruhr University Bochum, Bochum, Germany, 2University of Muenster, Muenster, Germany, 3Ichor Medical Systems, San Diego, CA, United States.
M. Hosseini1, M. Haji-Fatahaliha1, M. Jabbarzadegan1, S. Rasoulzadeh1, M. Ghafari-Khamene2, M. Yousefi1;
1
Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of, 2Islamic Azad University, Urmia, Iran, Islamic Republic of.
P. Riese1, S. Trittel1, M. Rohm2, T. Ebensen1, S. Herzig2, C. A. Guzmán1;
1
Helmholtz-Centre for Infection Research, Braunschweig, Germany, 2DKFZ, Heidelberg, Germany.
P.D.20.14
Intranasal vaccination with Pam3CSK4 and FSL-1 as adjuvants enhances mucosal and systemic immune responses to an Enterovirus 71 vaccine
P.D.20.15
A liposome-based influenza vaccine induces potent neonatal antibody responses
Y. L. Lin1, C. L. Chin2, P. Y. Cheng1, H. P. Yuan1, B. L. Chiang1,2;
1
Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan, 2Graduate Institute of Immunology, Collage of Medicine, National Taiwan University, Taipei, Taiwan.
B. Mastelic Gavillet1, C. S. Eberhardt1, F. Auderset1, D. Christensen2, E. Agger2, P. Andersen2, P. Lambert1, C. Siegrist1;
1
University of Geneva, Geneva, Switzerland, 2Statens Serum Institut, Copenhagen, Denmark.
P.D.20.16 Neutrophil responses to adjuvants used in allergy vaccines
M. Reithofer, D. Polak, B. Bohle, B. Jahn-Schmid;
Institute for Pathophysiology and Allergy Research, MCCA PhD Programme, Vienna, Austria.
P.D.20.17
Development of an adjuvant system based on pathogen-mimicking nanoparticles to enhance dendritic cell activation
N. Munoz-Wolf1, E. Collison1, J. Sirard2, E. C. Lavelle1;
1
Trinity Biomedical Science Institute -Trinity College Dublin, Dublin, Ireland, 2Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Lille, France.
P.D.20.18 CD8+ T cell fate and function influenced by antigen-specific virus-like nanoparticles co- expressing membrane tethered IL-2
D. Wojta-Stremayr1,2, A. Neunkirchner1,2, B. Srinivasan1, D. Trapin1, K. G. Schmetterer1, W. F. Pickl1,2;
1
Institute of Immunology, Vienna, Austria, 2Christian Doppler Laboratory for Immunomodulation, Vienna, Austria.
P.D.20.19 Evaluating Use of the Probiotic Yeast Saccharomyces boulardii for the Synthesis and Delivery of Oral Therapeutics and Vaccines
L. E. Hudson1, C. D. McDermott1, M. B. Fasken1, E. G. Kuiper1, D. B. Guiliano2, A. H. Corbett1, T. J. Lamb1;
1
Emory University, Atlanta, GA, United States, 2University of East London, London, United Kingdom.
P.D.20.20
CXCL10 production and antigen presentation to CD8 T cells after transcutaneous and intradermal administration of MVA vaccine in human skin
P.D.20.21
Subcutaneous application of a tick-borne-encephalitis vaccine leads to a higher reactogenicity profile but similar protective immune responses as the intra
muscular route
J. Gonnet1, L. Weiss1,2, D. Boccara1,3, C. Sylvain1, N. Yahia1, M. Dufossee1, R. Wagner4, B. Verrier5, A. Moris1, A. Vogt1,2, M. Mimoun3, B. Combadiere1, H. Perrin1;
1
Centre d’Immunologie et des Maladies Infectieuses-Paris (Cimi-Paris), Inserm U1135, Sorbonne Universités UPMC université Paris 06 UMRS CR7, CNRS ERL8255, Paris, France, 2Clinical Research Center for
Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany, Berlin, Germany, 3Service de chirurgie plastique reconstructrice, esthétique, centre des
brûlés, hopital Saint-Louis, Assistance Publique Hôpitaux de Paris, Paris, France, 4Molecular Microbiology and Gene Therapy Unit, Institute of Medical Microbiology and Hygiene, University of Regensburg,
Regensburg, Germany, 5Institut de Biologie et Chimie des proteins UMR 5305, CNRS/Université de Lyon, Lyon, France.
S. Hopf1, E. Garner-Spitzer1, M. Hofer1, M. Kundi2, O. Kistner3, U. Wiedermann1;
1
Institute of Specific Prophylaxis and Tropical Medicine, Center of Pathophysiology, Infectiology & I, Vienna, Austria, 2Institute of Environmental Health, Medical University of Vienna, Vienna, Austria,
3
Clinical Virology & Scientific Affairs, BioScience, Baxter Innovations GmbH, Vienna, Austria.
111
Chairpersons: Peter Korosec; Golnik, Slovenia / Laurent Mascarell; Antony, France
P.D.21.01
Perinatal application of a probiotic Escherichia coli strain for primary prevention of type I allergy in mice
P.D.21.02
A therapeutic approach for allergy based on antibody conjugates bi-specific for ICAM1 and allergens to prevent migration of allergens through mucosal barriers
P.D.21.03
A novel glutarimide derivative XC8 suppresses acute experimental allergic asthma in BALB/c mice
C. Zwicker1, M. R. Hassler2, A. Neunkirchner3, G. Egger2, U. Wiedermann1, I. Schabussova1;
1
Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Immunology and Infectiology, Medical University of Vienna, Vienna, Austria, 2Clinical Institute of Pathology, Medical
University of Vienna, Vienna, Austria, 3Institute of Immunology, Center for Pathophysiology, Immunology and Infectiology, Medical University of Vienna, Vienna, Austria.
C. Madritsch1, J. Eckl-Dorna2, K. Blatt3, I. Ellinger4, M. Kundi5, V. Niederberger2, P. Valent3, R. Valenta1, S. Flicker1;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Department
of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria, 3Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria,
4
Division of Cellular and Molecular Pathophysiology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria, 5Institute of Environmental Health, Center of
Public Health, Medical University of Vienna, Vienna, Austria.
S. Kazemi1, D. Reiner1, R. Lee1, G. Dekan2, T. Kromova3, A. Rydlovskaya3, O. Proskurina3, V. E. Nebolsin3, M. M. Epstein1;
1
Department of Dermatology DIAID, Medical University of Vienna, Vienna, Austria, 2Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria, 3LLC Pharmenterprises, Moscow, Russian
Federation.
P.D.21.04 the immunomodulatory effect of imperatonin on dendritic cells and in ovalbumin-induced asthmatic mice
C. L. Lin1, C. C. Wang2, H. L. Wu1, Y. L. Lee3;
1
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan, 2School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, 3Department of
Microbiology and Immunology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
P.D.21.05
Prevention and therapy of allergy by parasite derived immunomodulators
M. Drinic1, I. Schabussova1, A. Wagner1, B. Ruttkowski2, A. Joachim2, U. Wiedermann1;
1
Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2University of Veterinary Medicine, Vienna,
Austria.
P.D.21.06 Humanized mice as in vivo model for therapy of IgE-mediated allergy
C. Vizzardelli1, B. Nagl1, A. Neunkirchner2, C. Kitzmüller1, B. Jahn-Schmid1, B. Bohle1;
1
Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria, 2Institute of Immunology, Medical University of Vienna, Vienna, Austria.
P.D.21.07
Recombinant probiotic bacteria expressing allergen-chimers for the neonatal prevention of poly-sensitization
Wednesday
P. J. Sarate1, S. Heinl2, C. Daniel3, H. Kozákova4, R. Grabherr2, I. Schabussova1, U. Wiedermann1;
1
Institute of Specific Prophylaxis and Tropical Medicine, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Kinderspitalgasse 15, Wien, Austria, 2(c/o) CD Laboratory for
Genetically Engineered Lactic Acid Bacteria Department of Biotechnology University of Natural Resources and Life Sciences VIBT, Wien, Austria, 3Institut Pasteur de Lille, Center for Infection and Immunity
of Lille, Universite´ Lille Nord de France, CNRS, UMR 8204, Institut National de la Sante´ et de la Recherche Me´ dicale, Lille, France, 4Laboratory of Immunology and Gnotobiology, Institute of Microbiology
of Academy of Sciences of Czech republic,V.V.I., Novy Hradek, Czech Republic.
P.D.21.08 QS-21 in combination with alum allows reduction of antigen-amount in allergen-specific grass pollen immunotherapy in a preclinical model
U. Baranyi1,2, M. Focke-Tejkl1,3, B. Linhart1,3, F. Stolz4, A. Neubauer4, R. Henning4, T. Wekerle1,2, R. Valenta1,3;
1
Medical University of Vienna, Vienna, Austria, 2Department of Surgery, Vienna, Austria, 3Div. of Immunopathology, Dept. of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology
and Immunology, Vienna, Austria, 4Biomay AG, Vienna, Austria.
P.D.21.09 Allergen-specific IgG antibodies suppress allergen-induced lung inflammation and airway hyperresponsiveness in murine models of birch and grass pollen allergy
B. Linhart, M. Narayanan, M. Focke-Tejkl, S. Vrtala, R. Valenta;
Dept. of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
P.D.21.10
The Vienna Challenge Chamber as a tool to monitor immediate allergic reactions and treatment effects in patients with mite allergic rhinitis
P.D.21.11
Molecular-based allergy diagnostics in atopic dermatitis patients
P.D.21.12
Oral delivery of allergen-specific vaccination using recombinant Lactobacillus rhamnosus GG in a murine model of birch pollen allergic asthma
P.D.21.13
Superior immunogenicity of BM32 a recombinant B cell epitope-based grass pollen allergy vaccine over established allergen extract-based vaccines
P.D.21.14
Interaction of neuraminidase-coated microparticles with human intestinal epithelial cells
P.D.21.15
Modulation of atopic immune responses by transfer of allergen laden alveolar macrophages
P. Zieglmayer, R. Zieglmayer, P. Lemell, F. Horak;
Vienna Challenge Chamber, Allergy Center Vienna West, Vienna, Austria.
O. V. Shtyrbul, E. S. Fedenko, O. G. Elisyutina;
Institute of Immunology, Moscow, Russian Federation.
I. Spacova1, S. F. Seys1, R. Dockx1, M. I. Petrova1, F. C. Devos1, A. Kasran1, J. A. Vanoirbeek1, J. L. Ceuppens1, J. Vanderleyden1, S. Lebeer1,2;
1
KU Leuven, Leuven, Belgium, 2University of Antwerp, Antwerp, Belgium.
M. Weber1, M. Focke-Tejkl1, K. Niespodziana1, B. Linhart1, A. Neubauer2, H. Huber2, R. Henning2, R. Valenta1;
1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Biomay AG,
Vienna, Austria.
S. C. Diesner1,2, C. Schultz1, S. Exenberger1, E. Fuerst1, X. Wang3, F. Roth-Walter1,4, D. Heiden1, I. Pali-Schöll1,4, E. Jensen-Jarolim1,4, F. Gabor3, E. Untersmayr1;
1
Medical University of Vienna, Department of Pathopysiology and Allergy Research, Vienna, Austria, 2Medical University of Vienna, Department of Paediatrics and Adolescent Medicine, Vienna, Austria,
3
University of Vienna, Department of Pharmaceutical Technology and Biopharmaceuticals, Vienna, Austria, 4Comparative Medicine, Messerli Research Institute of the University of Veterinary Medicine
Vienna, Medical University Vienna and University Vienna, Vienna, Austria.
K. Kolberg1,2, S. Barth3, R. Fischer1,4, T. Thepen1;
1
Fraunhofer IME, Dept. Pharmaceutical Product Development, Aachen, Germany, 2Uniklinik RWTH Aachen, Helmholtz Institute for Biomedical Engineering, Institute of Applied Medical Engineering,
Dept. of Experimental Medicine and Immunotherapy, Aachen, Germany, 3South African Research Chairpersons: in Cancer Biotechnology, Institute of Infectious Disease and Molecular Medicine (IDM),
Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, 4RWTH Aachen University, Institute for Molecular Biotechnology, Aachen,
Germany.
P.D.21.16 Production of a hypoallergenic variant of the major peanut allergen Ara h 2 in the baculovirus insect cell system for allergen-specific immunotherapy
A. Tscheppe1, D. Palmberger2, M. Bublin1, C. Radauer1, C. Palladino1, B. Gepp1, N. Lengger1, R. Grabherr2, H. Breiteneder1;
Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria, 2Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.
1
P.D.21.17
Targeting allergens to Xcr1+DCs for allergen-specific immunotherapy
S. Bobic, A. Gudjonsson, E. Fossum, B. Bogen;
K.G. Jebsen Influenza Vaccine Research Centre, Institute of Immunology, Oslo, Norway.
Chairpersons: Christine S. Falk; Heidelberg, Germany
112
P.D.22.01
Immune-stimulatory cytokines as an adjuvant to enhance cancer immunotherapy
P.D.22.02
Induction of anti tumor responses against malignant melanoma via antigen targeting in vivo
P.D.22.03
Cytotoxicity of defensins γ-thionin (Capsicum chinense) and PaDef (Persea americana var. drymifolia) against cancer cell lines
A. AlSaieedi1,2, A. Holler1, G. Bendle3, H. Stauss1;
1
Institute of Immunity and Transplantation, University College London (UCL), London, United Kingdom, 2King Abdulaziz University, Jeddah, Saudi Arabia, 3School of Cancer Sciences, University of
Birmingham, Birmingham, United Kingdom.
C. Lehmann1, K. Neubert1, L. Heger1, A. Baranska1, A. M. Staedtler1, V. Buchholz2, S. Yamazaki3, G. F. Heidkamp1, N. Eissing1, H. Zebroski4, M. C. Nussenzweig5, F. Nimmerjahn6, D. Dudziak1;
1
University Hospital Erlangen, Dept of Dermatology, Laboratory of DC Biology, Erlangen, Germany, 2TU-Munich, Institute of Medical Microbiology, Immunology and Hygiene, Munich, Germany, 3Hokkaido
University, Department of Microbiology and Immunology, Graduate School of Medicine, Sapporo, Japan, 4The Rockefeller University, Proteomics Resource Center, New York, NY, United States, 5The
Rockefeller University, Laboratory of Molecular Immunology, New York, NY, United States, 6University of Erlangen, Department of Biology, Chairpersons: of Genetics, Erlangen, Germany.
J. Guzmán Rodríguez, R. López Gómez, A. Ochoa Zarzosa, J. López Meza;
Universidad Michoacana de San Niculás de Hidalgo, Morelia, Mexico.
P.D.22.06 Galactose oxidase treatment of human or mouse mature dendritic cells enhances their potential in T cell priming and anti-tumor therapy
M. Heuer, A. Brandl, L. Schwab, K. Strecker, A. Beilhack, M. B. Lutz;
University of Würzburg, Würzburg, Germany.
P.D.22.07
Batf3-dependent dendritic cells direct antitumor cytotoxic T-lymphocyte vaccination
M. Enamorado, S. Iborra, D. Sancho;
CNIC, Madrid, Spain.
P.D.22.08 Long-term outcome of extranodal NK/T cell lymphoma patients treated with post-remission therapy using EBV LMP1 and LMP2a-specific CTLs
S. G. Cho1, N. Kim2, H. J. Sohn3, S. K. Lee4, S. T. Oh5, H. J. Lee3, H. I. Cho6, H. W. Yim7, S. E. Jung8, G. Park9, J. H. Oh10, B. O. Choi11, S. W. Kim12, S. W. Kim12, N. G. Chung13, J. W. Lee1, Y. S. Hong14, T. G. Kim3;
1
Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary’s Hospital. College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 2Institute for
Translational Research and Molecular Imaging, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 3Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic
University of Korea,, Seoul, Korea, Republic of, 4Department of Medical Lifescience, College of Medicine, The Catholic University of Korea3Medical Lifescience, Seoul, Korea, Republic of, 5Department of
Medical Lifescience, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 6Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic
of, 7Department of Preventive Medicine, Seoul St. Mary’s Hospital. College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 8Department of Radiology, Seoul St. Mary’s Hospital.
College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 9Department of Pathology, Seoul St. Mary’s Hospital. College of Medicine, The Catholic University of Korea, Seoul, Korea,
Republic of, 10Department of Nuclear Medicine, Seoul St. Mary’s Hospital. College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 11Department of Radiation Oncology, Seoul St.
Mary’s Hospital. College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 12Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary’s Hospital. College of Medicine, The
Catholic University of Korea, Seoul, Korea, Republic of, 13Department of Pediatrics, Seoul St. Mary’s Hospital. College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 14Department of
Medical Oncoogy, Seoul St. Mary’s Hospital. College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of.
P.D.22.09 Erythrocytes used as tumor antigen carrier to target antigen-presenting cells: innovative approach for in situ cancer immunotherapy
M. Cremel, N. Guerin, W. Berlier, F. Horand, Y. Godfrien;
ERYTECH Pharma, Lyon, France.
P.D.22.11
Devising a glycoantigen specific DC immunotherapy to develop an efficient anti-tumor response in the hypoxic environment of glioblastoma
P.D.22.12
In vivo potential of recombinant granulysin against human tumors
P.D.22.13
Anti-cancer properties of Gastropodan hemocyanins in murine model of colon carcinoma
R. A. Ginwala1, D. Sagar1, L. Betesh1, X. Huang2, C. Foss3, S. Karakashev1, Z. K. Khan1, A. Mehta1, R. Philip2, M. Pomper3, M. Reginato1, P. Jain1;
1
Drexel University College of Medicine, Philadelphia, PA, United States, 2Immunotope Inc., Doylestown, PA, United States, 3Johns Hopkins Medicine, Bethesda, MD, United States.
S. Al-Wasaby, D. de Miguel, A. Aporta, J. Naval, B. Conde, L. Martinez-Lostao, A. Anel;
University of Zaragoza, Zaragoza, Spain.
V. Gesheva1, S. Chausheva1, N. Mihaylova1, I. Manoylov1, L. Doumanova1, K. Idakieva2, A. I. Tchorbanov1;
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria, 2Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.
1
P.D.22.14
The critical role of immune microenvironment in Hepatocellular carcinoma- the potential of TLR3 ligand as a novel immunotherapy
P.D.22.15
Application of polymer donors of nitric oxide for intensification of targeted therapy of solid tumors with polymer cytotoxic drugs
P.D.22.16
Graphene quantum dots suppress differentiation, maturation and anti-tumour functions of human dendritic cells
P.D.22.17
Nivolumab and urelumab enhance antitumor activity of human T lymphocytes engrafted in Rag2-/-IL2Rγnull immunodeficient mice
P.D.22.18
Peptide libraries for comprehensive coverage of the tumor mutanome in immune monitoring and immunotherapy
P.D.22.19
The combination of a trifunctional bispecific antibody with a CTLA-4-blocking antibody affects the induction of a CD4+ T-cell memory in a preclinical mouse model
P.D.22.20
Zoledronic acid-induced targeting of macrophages by γδ T cell
P.D.22.21
Polypeptide modification to alter plasma stability in a novel immunotherapeutic
P.D.22.22
Tumor cytotoxic dendritic cells modulate regulatory T cell responses
P.D.22.23
Generation of novel SNAP-tag conjugated immunotherapeutics
V. Horková1, L. Sivák1, M. Studenovský2, M. Šírová1;
1
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic, 2Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague 6, Czech
Republic.
S. Tomic1, D. Mihajlović1, Z. Marković2, V. Trajkovic3, M. Colic1;
1
Medical Faculty of the Military Medical Academy, Belgrade, Serbia, 2Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia, 3Institute for Microbiology and Immunology, School of
Medicine, University of Belgrade, Belgrade, Serbia.
I. Rodríguez1, F. Miguel1,2,3, O. Carmen2, A. Arantza1, R. María Esperanza1,2, M. Aizea1, L. Sara1, P. Jose Luis2, M. Salvador2, A. Carlos2, S. A. Kurt3, M. Guillermo4, S. Francesca5, H. Manuel5,6, K. J. Alan7, J.
Maria8, M. Ignacio1,2;
1
CIMA, Pamplona, Spain, 2Clínica Universidad de Navarra, Pamplona, Spain, 3Yale School of Medicine, New Haven, CT, United States, 4Universidad Austral, Pilar, Argentina, 5Centro Integral Oncológico
Clara Campal, Madrid, Spain, 6Spanish National Cancer Research Centre (CNIO), Madrid, Spain, 7Bristol Myers Squibb, Redwood City, CA, United States, 8Bristol Myers Squibb, Princeton, NJ, United States.
Wednesday
V. Chew;
Singhealth Translational Immunology and Inflammation Centre, Singapore, Singapore.
P. von Hoegen, U. Reimer;
JPT Peptide Technologies GmbH, Berlin, Germany.
N. Deppisch1, P. Ruf2, N. Eissler1,3, H. Lindhofer2, R. Mocikat1;
1
Helmholtz Zentrum München, Institut für Molekulare Immunologie, Munich, Germany, 2Trion Research GmbH, Martinsried, Germany, 3Karolinska Institutet, Department of Oncology-Pathology,
Stockholm, Sweden.
D. W. Fowler, J. Copier, A. G. Dalgleish, M. D. Bodman-Smith;
St. George’s University of London, London, United Kingdom.
L. Roberts, D. G. Miller, O. Goodyear, M. Cobbold;
A. Gautheron1, N. Janikashvili1, M. Trad1, M. Samson1, M. Ciudad1, N. Larmonier2, S. Audia1, B. Bonnotte1;
1
INSERM UMR 1098, Université de Bourgogne Franche-Comté, Dijon, France, 2Department of Pediatrics and Immunobiology, University of Arizona, Tucson, AZ, United States.
M. Woitok1,2, K. Kolberg3,1, R. Fischer1,2, S. Barth4;
1
Fraunhofer IME, Dept. of Pharmaceutical Product Development, Aachen, Germany, 2RWTH Aachen University, Institute for Molecular Biotechnology, Aachen, Germany, 3University Hospital RWTH
Aachen, Helmholtz Institute for Biomedical Engineering, Institute of Applied Medical Engineering, Dept. of Experimental Medicine and Immunotherapy, Aachen, Germany, 4South African Research
Chairpersons: in Cancer Biotechnology, Cape Town, South Africa.
Chairpersons: Marina Garin; Madrid, Spain / Ralf Dressel; Göttingen, Germany
P.D.23.01
Metabolic reprogramming of tumor-specific t cells boosts anti-tumor immunity by readjusting t cell metabolic fitness in the tumor microenvironment
P.D.23.02
Quantifying Antigen Thresholds for CAR T Cell Mediated Tumor Cell Killing
P.D.23.04
In vivo TCR transduced T cells demonstrate antigen-specific functionality upon systemic application of retroviral vectors
P.D.23.05
Study on the role of STAT3 activation in the stemness and immune suppressive activities of mesenchymal stem cells
P.D.23.06
Adipose-derived mesenchymal stem cells ameliorate established experimental arthritis by rapid induction of myeloid cells with a suppressive phenotype in
draining lymph nodes
P. Ho1,2, J. Bihuniak2, A. N. Macintyre3, X. Liu4, Y. Tsui2, E. Abel5, K. Insogna2, S. Feske6, J. W. Locasale4, M. W. Bosenberg2, J. C. Perales7, J. C. Rathmell3, S. M. Kaech2,8;
1
University of Lausanne, Lausanne, Switzerland, 2Yale University, New Haven, CT, United States, 3Duke University, Durham, NC, United States, 4Cornell University, Ithasca, NY, United States, 5University of
Iowa, Iowa City, IA, United States, 6New York University, New York City, NY, United States, 7University of Barcelona, Barcelona, Spain, 8Howard Hughes Medical Institute, Chevy Chase, MD, United States.
A. Plach1, V. Gudipati1, J. Rydzek2, M. Hudecek2, J. Huppa1;
1
Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Department of Medicine II - Hematology and
Medical Oncology, University of Würzburg, Würzburg, Germany.
I. Edes1, I. Schneider2, Q. Zhou2, C. J. Buchholz2, W. Uckert1;
1
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2Paul-Ehrlich-Institut, Langen, Germany.
H. C. Yu1, B. L. Chiang1,2;
1
M. Lopez-Santalla1, P. Mancheño-Corvo2, R. Menta2, J. Lopez-Belmonte3, O. DelaRosa2, J. Bueren1, W. Dalemans4, E. Lombardo2, M. Garin1;
1
CIEMAT/IIS Fundación Jiménez Díaz/CIBERER, Madrid, Spain, 2TiGenix SAU, Madrid, Spain, 3Farmacros, Albacete, Spain, 4TiGenix NV, Leuven, Belgium.
113
P.D.23.07
Tissue-specific Stem Cells - Localization, Preparation and Phenotype Characteristics
P.D.23.08
Immunomodulatory effect of human adipose-stromal cells is related to the administration route
P.D.23.09
Cyclosporine A and IFN-γ enhance human mesenchymal stromal cells immunosuppressive ability
P.D.23.10
How immune cell responses to 3D scaffolds stimulate MSC recruitment
U. Kozłowska1, A. Klimczak1, T. Jurek2, M. Czuba2, M. Rorat2;
1
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Sciences, Wroclaw, Poland, 2Department of Forensic Medicine, Medical University, Wroclaw, Poland.
M. Lopez-Santalla1, P. Mancheño-Corvo2, R. Menta2, O. DelaRosa2, J. A. Bueren1, W. Dalemans3, E. Lombardo2, M. Garin1;
1
CIEMAT/IIS Fundación Jiménez Díaz/CIBERER, Madrid, Spain, 2TiGenix SAU, Madrid, Spain, 3TiGenix NV, Leuven, Belgium.
J. Corbett1, I. Coulter2, K. English1;
1
Maynooth University, County Kildare, Ireland, 2Sigmoid Pharma Ltd., Dublin, Ireland.
H. R. Caires1,2,3, R. M. Gonçalves1,2, S. G. Santos1,2, M. A. Barbosa1,2,3, C. R. Almeida1,2;
INEB - Instituto de Engenharia Biomédica, Porto, Portugal, 2Instituto de Investigação e Inovação em Saúde, Porto, Portugal, 3ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Porto, Portugal.
1
P.D.23.11
New protocols for development of antigen-specific T regulatory cells in vitro
P.D.23.12
Genetically engineering HBV-specific CD8+T cells resistant to TRAIL-mediated apoptosis
P.D.23.13
Comparative immunomodulatory effect of clonogenic hASCs on PBMCs vs. isolated CD3+ lymphocytes
I. D. Stojanovic, T. Saksida, M. Kojdic, I. Nikolic, M. Vujicic, S. Stosic-Grujicic, D. Miljkovic;
Institute for Biological Research “Sinisa Stankovic”, University of Belgrade, Belgrade, Serbia.
I. Otano, F. Arce, H. Singh, A. Schurich, D. Peppa, R. Gilson, G. Fusai, H. Stauss, D. Escors, M. Maini;
University College of London, London, United Kingdom.
P. Martinez-Peinado1, S. Pascual-García1, D. Expósito1, M. Arribas-García de León2, E. Roche2, J. Sempere-Ortells1;
1
University of Alicante, San Vicente del Raspeig, Spain, 2University Miguel Hernández, Elche, Spain.
Chairpersons: Anna Fogdell-Hahn; Stockholm, Sweden / Eva Kriegova; Olomouc, Czech Republic
P.D.24.01 Joint bleeds increase the inhibitor response to human coagulation factor VIII in a haemophilia A rat model
K. M. Lövgren1,2, H. Soendergaard1, S. Skov2, B. Wiinberg1;
1
Novo Nordisk A/S, Maaloev, Denmark, 2University of Copenhagen, Frederiksberg, Denmark.
Wednesday
P.D.24.02
Risk factors of anti-drug antibodies (ADA) occurrence in multiple sclerosis
P.D.24.03
Antibodies against interferon beta and natalizumab in European multiple sclerosis patients
P.D.24.05
Comprehensive analysis of the CD4 T cell epitopes of chimeric therapeutic antibodies Infliximab and Rituximab identified in healthy donors and immunized
patients
S. Hässler1,2, D. Bachelet1,2, C. Mbogning1,2, J. Link3,2, R. Ramanujam3,2, M. Auer4,2, P. Hyldgaard Jensen5,2, C. Warnke6,2, K. Wolffram6,2, D. Buck7,2, V. Grummel7,2, B. Kieseier6,2, B. Hemmer7,2, H. Hartung6,2, P.
Soelberg Sorensen5,2, F. Deisenhammer4,2, P. Dönnes8,2, J. Davidson9,2, A. Fogdell-Hahn3,2, P. Broët1,10,2;
1
INSERM UMR1178, hôpital Paul Brousse, Villejuif, France, 2ABIRISK Consortium, Brentford, Middlesex, United Kingdom, 3Karolinska Institutet, Department of Clinical Neuroscience, Clinical
Neuroimmunology, Stockholm, Sweden, 4Department of Neurology, Innsbruck Medical University, Innsbruck, Austria, 5Danish Multiple Sclerosis Center, Copenhagen University Hospital, Copenhagen,
Denmark, 6University of Düsseldorf, Department of Neurology, Düsseldorf, Germany, 7Department of Neurology, Technische Universität München, Munchen, Germany, 8Scicross AB, Skövde, Sweden,
9
GlaxoSmithKline, Uxbridge, Middlesex, United Kingdom, 10Faculté de Médecine, Université Paris Sud, Kremlin-Bicêtre, France.
A. Fogdell-Hahn1, J. Link1, R. Ramanujam1, M. Auer2, S. Hässler3, D. Bachelet3, C. Sievers4, P. Hyldgaard Jensen5, C. Warnke6, K. Ingenhoven6, D. Buck7, B. Hemmer7, V. Grummel7, B. Kieseier6, H. Hartung6,
P. Soelberg Soerensen5, M. Comabella8, R. Lindberg4, T. Derfuss4, F. Deisenhammer2, C. Mbogning3, P. Broët3, A. Lawton9, J. Davidson9, P. Dönnes10;
1
Karolinska Institutet, Stockholm, Sweden, 2Innsbruck Medical University, Innsbruck, Austria, 3INSERM, Paris, France, 4University Hospital Basel, Basel, Switzerland, 5Rigshospitalet, Copenhagen, Denmark,
6
University of Düsseldorf, Düsseldorf, Germany, 7Technische Universität München, Munich, Germany, 8Hospital Universitari Vall d’Hebron, Barcelona, Spain, 9GlaxoSmithKline R&D, London, United
Kingdom, 10Sci Cross AB, Skövde, Sweden.
B. Maillere1, M. Hamze1, S. Meunier1, A. Goudet1, A. Gdoura1, N. Szely2, M. Pallardy2, F. Carbonnel3, X. Mariette4, C. Miceli-Richard4;
1
CEA, Gif sur Yvette, France, 2INSERM UMR 996, Chatenay-Malabry, France, 3Hôpitaux Universitaires Paris-Sud, Service de gastro-entérologie, Le Kremlin Bicêtre, France, 4Hôpitaux Universitaires ParisSud, Service de Rhumatologie, Le Kremlin Bicêtre, France.
P.D.24.06 Effect of Ganoderma lucidum basidiocarps cultivated on alternative substrate to functional aspects of human monocyte-derived dendritic cells
D. Zmijanjac1,2, M. Markovic3, S. Vasilijic1,4, D. Vucevic1,4, J. Cilerdzic2, M. Stajic2, J. Vukojevic2, B. Bozic1,2;
1
Institute for Medical Research, Military Medical Academy, Belgrade, Serbia, 2Faculty of Biology, University of Belgrade, Belgrade, Serbia, 3Faculty of Medicine, University of Nis, Nis, Serbia, 4Faculty of
Medicine of the Military Medical Academy, University of Defense in Belgrade, Belgrade, Serbia.
P.D.24.07
FVIII tolerization in a hemophilic mouse model
P. Milanov1, P. Quade-Lyssy1, S. Roth1, E. Seifried1, A. Pashov2, S. Lacroix-Desmazes3, J. Schüttrumpf4, J. Schwäble1;
1
Transfusion Medicine and Immunohaematology, German Red Cross Blood Donor Service Baden-Wuerttemberg - Hessen, Frankfurt, Germany, 2Department of Immunology, Institute of Microbiology, Sofia,
Bulgaria, 3Centre de Recherche des Cordeliers, Université Pierre et Marie Curie-Paris 6, INSERM UMR S 1138, Paris, France, 4Biotest AG, Dreieich, Germany.
P.D.24.08 In vitro assessment of immunogenicity of drug delivery systems
M. A. de Groot, T. C. Habraken, L. A. van der Linden, R. van der Zee, W. van Eden, F. Broere, A. J. Sijts;
Utrecht University, Utrecht, Netherlands.
P.D.24.09 Persistent non-pathogenic antibodies against human proteins in healthy individuals
F. M. Horling1, C. J. Hofbauer1, P. Allacher2, S. Till1, B. Abbühl1, F. Scheiflinger1, B. M. Reipert1;
Baxalta, Vienna, Austria, 2IMC University of Applied Sciences, Krems, Austria.
1
P.D.24.10 Novel insights into antibodies against polyethylene glycol (PEG) in healthy subjects
C. Lubich1, P. Allacher2, A. Bauer1, T. Prenninger1, F. M. Horling1, J. Siekmann1, F. Scheiflinger1, B. M. Reipert1;
1
Baxalta Innovations GmbH, Vienna, Austria, 2IMC University of Applied Sciences Krems, Krems, Austria.
P.D.24.11
Towards understanding the impact of sub-visible particles in protein therapeutics on the induction of unwanted immune responses
P.D.24.12
Synthetic vaccine particles for the induction of immunological tolerance to prevent anti-drug antibodies
P.D.24.13
AID/APOBECs linking immunity, chronic inflammation and cancer
C. Lubich, M. Malisauskas, T. Prenninger, E. Hopfner, F. Scheiflinger, B. Reipert;
Baxalta Innovations GmbH, Vienna, Austria.
T. K. Kishimoto, J. D. Ferrari, R. A. LaMothe, P. N. Kolte, A. P. Griset, C. O’Neil, A. Chalishazar, V. Chan, D. H. Altreuter, L. Johnston, R. A. Maldonado;
Selecta Biosciences, Watertown, MA, United States.
D. Mechtcheriakova1, M. Svoboda1, A. Meshcheryakova1, E. Jensen-Jarolim1,2, M. Jaritz3, P. Zimmermann4, R. Zeillinger5, G. Heinze6;
1
Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, 2Comparative Medicine, Messerli Research
Institute of the Veterinary University of Vienna, Medical University of Vienna and University of Vienna, Vienna, Austria, 3Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria,
4
Nebion AG, Zürich, Switzerland, 5Molecular Oncology Group, Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria, 6Section for Clinical
Biometrics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University Vienna, Vienna, Austria.
P.D.24.14 Revisiting antiphospholipid cut-off levels in obstetric morbidity versus thrombosis
M. Núñez-Beltrán1, A. Tejeda2, L. Fernández-Paredes1, A. Comins-Boo1, A. Carrasco2, S. Sánchez-Ramón1;
1
Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain, 2Department of Clinical Immunology, Hospital Ramón y Cajal, Madrid, Spain.
P.D.24.15
New biomarkers for the diagnosis and prognosis of asthma
S. Baos1, D. Calzada1, J. Quiralte2, F. Florido3, B. Cárdaba1,4;
1
IIS-Fundación Jiménez Díaz-UAM, Madrid, Spain, 2Hospital Universitario Vírgen del Rocío, Seville, Spain, 3Hospital Universitario San Cecilio, Granada, Spain, 4Ciber de Enfermedades Respiratorias,
CIBERES, Madrid, Spain.
P.D.24.16 Characterization of four functionally distinct human B-cell subsets that are defined by the expression of CD21 and CD86
M. A. García-Márquez, A. Shimabukuro-Vornhagen, M. von Bergwelt-Baildon;
University Hospital of Cologne, Cologne, Germany.
114
P.D.24.17
Usefulness of recombinant γ-gliadin 1 for identifying celiac disease patients and monitoring of adherence to gluten-free diet
B. Srinivasan1,2, M. Focke-Tejkl2, M. Weber2, S. Pahr2, A. Baar2, R. Atreya3, M. F. Neurath3, H. Vogelsang4, W. Huber5, R. Valenta2;
1
Institute of Immunology, CePII, MUW, Vienna, Austria, 2Division of Immunopathology, Department of Pathophysiology and Allergy Research, CePII, Medical University of Vienna, Vienna, Austria, 3Medical
Clinic 1, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, 4Department of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria, 5Department of Pediatrics
and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
P.D.25 Organ Transplantation
Chairpersons: Vera Rebmann; Essen, Germany / Alexander Rosenkranz; Graz, Austria
P.D.25.01
Retrospective study of the impact of C1q-binding donor-specific antibodies on allograft outcome in kidney transplantation
P.D.25.02
An extended pre-transplant humoral immunity profile to identify risk of severe infection in heart recipients. A multicenter study
P.D.25.03
Preliminary analysis of a randomized multicenter clinical trial of therapeutic use of intravenous immunoglobulin in solid organ transplantation with severe
infections and IgG hypogammaglobulinemia
J. Molina Alcaide1,2, A. Navas Romo1,2, M. Agüera Morales1,2, P. Aljama Garcia1,2, A. Rodriguez Benot1,2, R. Solana Lara1,2;
1
Hospital Universitario Reina Sofia, Cordoba, Spain, 2Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Cordoba, Spain.
J. Carbone1, J. Fenandez-Yañez1, J. Palomo1, M. Gomez-Sanchez2, M. Crespo-Leiro3, M. Paniagua3, L. Almenar4, M. Cebrian4, G. Rabago5, J. Segovia6, M. Gomez6, J. Lopez7, L. Garcia-Guereta8, S. Mirabet9,
M. Jaramillo1, J. Navarro1, E. Sarmiento1;
1
Hospital General Universitario Gregorio Marañon, Madrid, Spain, 2Hospital Universitario Doce de Octubre, Madrid, Spain, 3Complejo Hospitalario Universitario Juan Canalejo, La Coruña, Spain, 4Hospital
Universitario La Fe, Valencia, Spain, 5Clinica Universitaria, Navarra, Spain, 6Hospital Universitario Puerta de Hierro, Madrid, Spain, 7Hospital Clínico Universitario, Valladolid, Spain, 8Hospital Universitario La
Paz, Madrid, Spain, 9Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
J. Carbone1, J. Fernandez-Yañez1, P. Diez1, I. Sousa1, M. Rodriguez1, M. Salcedo1, D. Rincon1, J. Segovia2, R. Laporta2, A. De Pablos3, L. Calahorra1, J. Navarro1, M. Valerio1, M. Arraya1, E. Fernandez-Cruz1, E.
Sarmiento1;
1
Hospital General Universitario Gregorio Marañon, Madrid, Spain, 2Hospital Universitario Puerta de Hierro, Madrid, Spain, 3Hospital Universitario Doce de Octubre, Madrid, Spain.
P.D.25.04
Heart recipients treated with specific anti-cytomegalovirus intravenous immunoglobulin show a decrease in activation status of T cells
P.D.25.05
HLA Allels and Anti-HLA Antibodies Frequencies’ in the Mediterranean Region of Turkey
P.D.25.06
HCMV-specific HLA-E-restricted CD8 T cells in kidney transplant recipients: a non conventional but frequent and long lasting response
P.D.25.07
Reconstitution of specific antibodies in heart recipients with hypogammaglobulinemia by preventive use of intravenous immunoglobulin: results of a clinical trial
P.D.25.08
Immune mechanisms of allograft rejection between lamellar and penetrating keratoplasty in murine model
P.D.25.09
Co-stimulation Blockade by Belatacept suppresses allo- but not virus-specific T cell responses in vitro, adjusts peripheral T cell subsets and suppresses cytokine
and chemokine levels in long-term treated kidney recipients
J. Carbone, N. Lanio, A. Gallego, J. Navarro, J. Fernandez-Yañez, I. Sousa, E. Sarmiento;
N. Jouand1,2, M. Allard1, J. Desfrançois-Noël3, P. Guerif2,4, M. Giral2,4, N. Gervois1, B. Charreau2,4;
1
UMR INSERM 892, CNRS 6299, Université de Nantes, CRCNA, Nantes, France, 2UMR INSERM 1064, Université de Nantes, ITUN, Nantes, France, 3Cytocell Facility, Nantes, France, 4CHU de Nantes,
Nantes, France.
J. Carbone, J. Navarro, J. Rodriguez-Molina, M. Jaramillo, L. Calahorra, M. Arraya, P. Diez, I. Sousa, J. Fernandez-Yañez, J. Palomo, J. Hortal, P. Muñoz, R. Alonso, E. Fernandez-Cruz, E. Sarmiento;
H. Lee, J. Kwon, C. Joo;
Department of Ophthalmology and Catholic Institute for Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of.
C. S. Falk1, C. Neudörfl1, K. Daemen1, J. Keil1, A. Zierau1, W. Hammerschmidt2, R. Zeidler3, C. Blume4, H. Haller5, H. Schrem6, G. Grannas6, F. Lehner6;
1
Inst. Transplant Immunology, IFB-Tx, MHH, Hannover, Germany, 2Research Unit Gene Vectors, HMGU,, Munich, Germany, 3research Unit Gene VExtors, HMGU, Munich, Germany, 4Institute of Technical
Chemistry, Leibniz University, Hannover, Germany, 5Dept. of Nephrology and Hypertension, MHH, Hannover, Germany, 6Dept. of Abdominal and Transplant Surgery, MHH, Hannover, Germany.
P.D.25.10
Wednesday
B. Basturk1, B. Kantaroglu2, M. Kavuslu2, A. Noyan3, D. Torun4;
1
Baskent University Faculty of Medicine, Department of Immunology, Ankara, Turkey, 2Baskent University Adana Research and Medical Center, Immunology-Tisse Typing Laboratory, Adana, Turkey,
3
Baskent University Faculty of Medicine, Department of Pediatry, Adana, Turkey, 4Baskent University Faculty of Medicine, Department of Internal Medicine, Adana, Turkey.
Innate cytokine responses are required for T cell activation leading to clinically rejection after pediatric liver transplantation
C. S. Falk1, I. Goldschmidt2, F. Mutschler2, E. Pfister2, F. Lehner3, C. Neudörfl1, C. Neudörfl1, J. Keil1, K. Daemen1, K. Daemen1, A. Karch4, R. Mikolajczyk4, U. Baumann2;
Inst. of Transplant Immunology, IFB-Tx, MHH, Hannover, Germany, 2Dept. Pediatric Nephrology and Metabolic Diseases, MHH, Hannover, Germany, 3Dept. of Abdominal and Transplant Surgery, MHH,
Hannover, Germany, 4Dept. of Epidemiology, HZI, Braunschweig, Germany.
1
P.D.25.11
NFkB location in T-cells is promising to monitor immunosuppression after lung transplantation
P.D.25.12
a peptide to reduce pulmonary edema in a rat model of lung transplantation
P.D.25.13
Modulation of Cell Microenvironments with Oxygen Tension and Macromolecular Crowding: A Multifactorial Approach Towards In Vitro Organogenesis
P.D.25.14
Role the platelet in an experimental model of renal ischemia and reperfusion
P.D.25.15
CD8+ KIR2D/3D+ T cells in samples of blood versus fine needle aspiration cytology in stable kidney transplant patients: a longitudinal cohort study
P.D.25.16
Novel role for NK cells in solid organ transplantation
P.D.25.17
Evaluation of TLR2 R753Q in Heart Transplant Recipients as Risk Factor for Cytomegalovirus Infection
U. Sommerwerck1, M. Lindemann2, B. E. Kleibrink1, T. Rabis1, G. Weinreich1, M. Kamler3, H. Teschler1, P. A. Horn2, V. Rebmann2;
1
Department of Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital Essen, Essen, Germany, 2Institute for Transfusion Medicine, University Hospital Essen, Essen, Germany,
3
Department of Thoracic Transplantation, University Hospital Essen, Essen, Germany.
K. Schossleitner1, A. Habertheuer2, P. Petzelbauer1;
1
Dermatology, Vienna, Austria, 2Surgery, Vienna, Austria.
A. Satyam, P. Kumar, A. Pandit, D. Zeugolis;
Network of Excellence for Functional Biomaterials (NFB), National University of Ireland, Galway, Galway, Ireland.
R. C. Silva1, R. J. Felizardo2, M. A. Cenedeze2, T. T. Braga1, A. P. Silva2, M. D. Casa3, N. O. Camara1;
1
University of São Paulo, São Paulo, Brazil, 2Federal University of São Paulo, São Paulo, Brazil, 3Institute Butanta, São Paulo, Brazil.
A. Caballero, E. Palma, P. Ruiz-Esteban, E. Sola, L. Fuentes, E. Rudas, L. Perea, D. Hernandez;
Carlos Haya Regional University Hospital, IBIMA, University of Malaga, Malaga, Spain.
T. Lieke, O. Beetz, J. Hauschildt, B. Buck, B. Trautewig, H. Bektas, F. Vondran;
M. Schneider1, T. Matiqi1, M. Andreas2, R. Strassl3, A. Zuckermann2, C. Jungbauer4, C. Steininger1;
MUV, Clinic of Internal Medicine I, Department of Infectious Diseases and Tropical Medicine, Vienna, Austria, 2Departments of Surgery, Div. of Cardiac Surgery, Medical University of Vienna, Vienna, Austria,
3
Institute of Virology, Medical University of Vienna, Vienna, Austria, 4Blood Service for Vienna, Lower Austria and Burgenland, Austrian Red Cross, Vienna, Austria.
1
P.D.25.18
Early outcome in prospective study of five transplanted patients with preformed non-C1q-binding donor-specific antibodies
P.D.25.19
CMV-induced expression of CD244 after liver transplantation is associated with CD8+ T-cell hyporesponsiveness to allo-antigen
P.D.25.21
The new technique for receiving autoprostheses for the bladder wall defects replacement
A. Navas Romo1,2, J. Molina Alcaide1,2, M. Agüera Morales1,2, P. Aljama Garcia1,2, A. Rodriguez Benot1,2, R. Solana Lara1,2;
1
Hospital Universitario Reina Sofia, Cordoba, Spain, 2Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Cordoba, Spain.
E. L. de Mare-Bredemeijer1, X. Shi1, S. Mancham1, R. van Gent1, M. van der Heide-Mulder1, R. de Boer2, M. H. Heemskerk2, J. de Jonge1, L. J. van der Laan1, H. J. Metselaar1, J. Kwekkeboom1;
1
Erasmus MC - University Medical Centre, Rotterdam, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands.
B. Iushkov1,2,3, N. Tyumentseva1,2,3, S. Medvedeva1,2,3, A. Sarapultsev1,3;
Institute of Immunology and Physiology, Ural Branch of RAS, Ekaterinburg, Russian Federation, 2GBUZSO Institute of Medical Cell Technologies, Ekaterinburg, Russian Federation, 3Federal State
Autonomous, Educational Institution of Higher Professional Education, Ural Federal University Named After the First President of Russia B. N. Yeltsin, Ekaterinburg, Russian Federation.
1
115
P.D.26 Immunosuppressive and Tolerogenic Treatment
Chairpersons: Giuseppe Cappellano; Innsbruck, Austria / Eduard Palou; Barcelona, Spain
P.D.26.01 Low risk of allo-sensitization after intravenous administration of allogeneic adipose derived stem cells in refractory rheumatoid arthritis patients
C. Martín1, C. Ramirez2, M. Moreno1, E. Lombardo2, W. Dalemans3, J. Castañer1, O. DelaRosa2;
1
Hospital Universitario Ramón y Cajal, Madrid, Spain, 2R&D department.Tigenix S.A.U, Madrid, Spain, 3R&D department.Tigenix NV, Lovaina, Belgium.
P.D.26.02 LabscreenMix® assay allows us to discriminate between a memory response and development de novo anti-HLA antibodies
C. Martín Martín, M. Moreno, I. Gañán, J. Castañer;
Hospital Universitario Ramón y Cajal, Madrid, Spain.
P.D.26.03
Development of a screening assay to detect new targets in B cell activation cascade
K. Van Belle, J. Herman, M. Waer, T. Louat;
KU Leuven, Leuven, Belgium.
P.D.26.04 Clinical grade Multipotent Adult Progenitor Cells suppress IL-7 driven stimulation of T cells in vivo
F. Carty1, J. L. Reading2, T. I. Tree2, A. E. Ting3, R. Deans3, K. English1;
1
Institute of Immunology, Maynooth University, Kildare, Ireland, 2Department of Immunobiology, King’s College London, London, United Kingdom, 3Athersys Inc., Cleveland, OH, United States.
P.D.26.05 Pre-activation of recipient-derived mesenchymal stem cells (MSCs) enhances their immunosuppressive properties and can prolong corneal allograft survival
N. Murphy1, O. Treacy1, A. E. Ryan1, P. Lohan1, K. Lynch1, M. Morcos1, G. Fahy2, M. D. Griffin1, T. Ritter1;
1
Regenerative Medicine Institute, National University of Ireland Galway, Galway, Ireland, 2University Hospital Galway, National University of Ireland Galway, Galway, Ireland.
P.D.26.06 Effects of cyclosporine A and rapamycin on the ability of immature dendritic cells to activate T cells
M. Machcińska1, A. Cieślikowska1, M. Rząca1, G. Korczak-Kowalska1,2;
1
Department of Immunology, Faculty of Biology, University of Warsaw, Warsaw, Poland, 2Transplantation Institute, Medical University of Warsaw, Warsaw, Poland.
P.D.26.07 The effect of IL-2/α-IL-2 complexes on distinct lymphocyte populations
B. Mahr, L. Unger, K. Hock, N. Pilat, U. Baranyi, C. Schwarz, A. M. Farkas, T. Wekerle;
P.D.26.08 Nk cells of kidney transplanted patients display an activated phenotype that is influenced by immunosuppression and pathological staging
C. Neudörfl1, U. Hoffmann1, K. Daemen1, J. Keil1, M. Stevanovic-Meyer1, F. Lehner2, H. Haller3, C. Blume4, C. S. Falk1;
1
Inst. of Transplant Immunology, Hannover Medical School, Hannover, Germany, 2Department of Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany, 3Department of
Nephrology and Hypertension, Hannover Medical School, Hannover, Germany, 4Institute of Technical Chemistry, Leibniz University Hannover, Hannover, Germany.
P.D.26.09 Immunosuppressive drugs modulate the microenvironment in solid organ transplantation by suppressing the mTOR signaling pathway and chemokine secretion
in epithelial cells
Wednesday
A. Akhdar1, B. Mueller2, C. Neudoerfl1, M. Stevanovic-Meyer1, K. Daemen1, J. Keil1, F. Lehner3, F. Vondran3, H. Haller4, C. Blume4,5, C. Falk1;
1
Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, 2current working adress: MorphoSys, Munich, Germany, 3Department of General, Visceral, and Transplantation Surgery,
Hannover, Germany, 4Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany, 5Institute of Technical Chemistry, Leibniz University Hannover, Hannover, Germany.
P.D.26.10 Targeting the PD-1:PD-Ligand inhibitory pathway in transgenic models for xenotransplantation
A. Buermann1, S. Petkov2, B. Petersen2, W. Baars1, H. Niemann2, R. Schwinzer1;
1
Transplant Laboratory, Department of General-, Visceral-, and Transplantation Surgery, Hannover Medical School, Hannover, Germany, 2Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut,
Mariensee, Germany.
P.D.26.11 Interleukin-34, a new role in regulatory T cell function and transplant tolerance
S. Bézie1, E. Picarda1, J. Ossart1, L. Tesson1, C. Usal1, K. Renaudin2, I. Anegon1, C. Guillonneau1;
1
INSERM U1064-ITUN, Nantes, France, 2CHU, Nantes, France.
P.D.26.12 The impact of induction immunosuppression for renal transplant patients
L. Dican1,2, L. Loga2, R. Lucaciu1;
1
Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, 2Clinical Institute of Urology and Renal Transplantation, Cluj-Napoca, Romania.
P.D.26.13
Transplantable immune modulation in response to autologous cancer cells
I. Zerva1, C. Simitzi1, A. Ranella2, E. Stratakis2, I. Athanassakis1;
Department of Biology, University of Crete, Heraklion, Greece, 2Institute of Electronic Structure and Laser(IESL), Foundation for Research and Technology, Heraklion, Greece.
1
P.D.26.14 Thymoglobuline: more than T-cell depletion
M. Buszko1, B. Jakic1, P. Hoertnagl2, H. Schennach2, L. Chatenoud3, H. Dietrich4, G. Wick1, G. Cappellano1;
1
Division of Experimental Pathophysiology & Immunology, Medical University of Innsbruck, Innsbruck, Austria, 2Central Institute of Blood Transfusion and Immunology, University Clinics, Innsbruck, Austria,
3
Université Paris Descartes, Sorbonne Paris Cité, Hôpital Necker-Enfants Malades, Paris, France, 4Central Laboratory Animal Facility, Medical University of Innsbruck, Innsbruck, Austria.
P.D.26.15
The secret behind antithymocyte globulins
I. Popow1, J. Leitner2, K. Grabmeier-Pfistershammer3, O. Majdic2, G. Zlabinger2, M. Kundi4, P. Steinberger2;
1
St.Anna Children´s Hospital, Vienna, Austria, 2Institute of Immunology, Medical University Vienna, Vienna, Austria, 3Department of Dermatology, Medical University Vienna, Vienna, Austria, 4Institute of
Environmental Health, Medical University Vienna, Vienna, Austria.
P.D.26.16 The generation of allogeneic regulatory T cells from umbilical cord blood
S. Srivastava1,2, J. Girdlestone2, C. Navarrete1,2;
1
University College London, London, United Kingdom, 2NHS Blood and Transplant, London, United Kingdom.
P.D.26.17
Effect of storage time on T cell subsets in red blood cell suspensions
S. H. Bal1,2, Y. Heper3, F. Güvenç4, L. T. Kumaş1,2, F. Budak1, G. Göral5, H. B. Oral1;
1
Department of Immunology, Faculty of Medicine, Uludag University, Bursa, Turkey, 2Department of Microbiology/Immunology, Institute of Health Sciences, Uludag University, Bursa, Turkey, 3Department
of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Uludag University, Bursa, Turkey, 4Life Sciences Program, Immunology, Toronto University, Toronto, ON, Canada, 5Department of
Medical Microbiology, Faculty of Medicine, Uludag University, Bursa, Turkey.
P.D.26.18 The effect of dichloroacetate on certain glycolytic enzymes and on the signature transcription factors of Th1, Th2, Th17 and Treg in human alloreactive CD4+
T-cells
M. Sounidaki, T. Eleftheriadis, G. Pissas, I. Stefanidis;
1Department of Nephrology, School of Medicine, University of Thessaly, Larisa, Greece.
P.D.26.19 Short term rapamycin treatment permits antigen-encoding bone marrow engraftment and tolerance induction in mice under immune-preserving conditioning
K. Bhatt, R. Steptoe;
UQDI, TRI, Brisbane, Australia.
P.D.27 MHC and other Gene Polymorphisms in Health & Disease
Chairpersons: Milan Buc; Bratislava, Slovakia / Ines Zidi; Tunis, Tunisia
116
P.D.27.01
Apoptosis activity of p53 in leukemia cell lines retaining wild-type p53
P.D.27.02
Susceptibility genes HLA and microvascular complications of auto immune diabetes in the Algerian population
P.D.27.03
Expression level of celiac disease predisposing DQA1*05 and DQB1*02 alleles in professional antigen presenting cells carrying the DR3-DQ2.5 haplotype
P.D.27.04
Analysis of HFE and non-HFE gene mutations (TFR2 and FPN1) in patients with phenotypic hemochromatosis from the Deba valley,Basque country
S. Gu1, Z. LIU2;
1
School of Rehabilitation Sciences, Seirei Christopher University, Hamamatsu, Japan, 2Southwest Hospital, Chongqing, China.
E. Mihoubi1, H. Amroun2, M. Azzouz3, F. Bouldjennet1, A. Boudiba3, M. Abbadi2, R. Raache1, N. Attal2;
1
University of Sciences adn Technology Houari Boumédiene, Alger, Algeria, 2Département d’immunologie, Institut Pasteur d’Algérie (IPA), Alger, Algeria, 3Service de diabétologie, CHU Mustapha, Alger,
Algeria.
L. Pisapia1, S. Pisascia2, A. Camarca3, P. Barba1, G. Del Pozzo1, C. Gianfrani2;
1
CNR-Institute of Genetics and Biophysics “Adriano Buzzati Traverso”, Naples, Italy, 2CNR- Institute of Protein Biochemistry, Naples, Italy, 3CNR-Institute of Food Sciences-ISA, Avellino, Italy.
L. Aragon1, M. de Juan1, A. Gorostidi2, O. Zuriarrain2, A. Castiella3, E. Zapata3, L. Zubiaurre3, A. Iribarren3, P. Otazua4;
1
Immunology Hospital Donostia, Donostia San Sebastian, Spain, 2Biodonostia Hospital Donostia, Donostia San Sebastian, Spain, 3Gastroenterology, Mendaro Hospital,, Mendaro.Guipuzcoa, Spain,
4
Gastroenterology, Mondragon Hospital., Mondragon .Guipuzcoa, Spain.
P.D.27.05
Aspirin susceptibility Study based in HLA genes from Amerindian Colombian Population
P.D.27.06
The peptidome of the Behçet’s disease- associated HLA-B*51:01 allotype includes two sub-peptidomes differentially shaped by ERAP1
P.D.27.07
Association of the HLA-G, the HLA-E and HLA-F genes with thyroid diseases
C. H. Parga Lozano1,2, Y. R. Ortega García2;
1
Universidad Libre, Barranquilla, Colombia, 2Pharmacotherapy and immunology group GRUFAIN, Cartagena, Colombia.
P. Guasp1, C. Alvarez-Navarro1, M. Marcilla2, E. Barnea3, A. Admon3, J. López de Castro1;
1
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain, 22Proteomics Unit, Centro Nacional de Biotecnología (CSIC), Madrid, Spain, 3Faculty of Biology, Technion -Israel Institute of
Technology, Haifa, Israel.
W. Babay1, E. Zeddini1, N. Nefzi1, A. Laaribi1, H. Ben Yahia1, A. Bouaziz2, H. Tlili3, I. Zidi1;
1
Laboratory Microorganismes et Biomolécules Actives, Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia, 2Ecole supérieure des Sciences et Techniques de la Santé de Sousse, Sousse,
Tunisia, 3Groupement de sante de base, Sousse, Tunisia.
P.D.27.08 Casp-8 gene polymorphism (rs13416436) is not associated with preeclampsia in a Brazilian population
I. C. Orlando Júnior, S. C. Tanaka, R. F. Oliveira, M. A. Balarin, S. R. Silva, C. W. Pissetti;
UFTM, Uberaba, Brazil.
P.D.27.09
Soluble HLA-E and HLA-E polymorphism - predictors of early disease progression in CLL
P.D.27.10
A case of Stiff Person Syndrome: immunomodulatory effect of benzodiazepines. Successful rituximab and tizanidine therapy
P.D.27.11
The impact of STRs mutations in parentage testing cases
P.D.27.12
A genetic variation in HLA-DR region associated with hypomethylation and high expression of HLA-DRB1 and DRB5 genes contribute to enhanced autoantibody
production in systemic lupus erythematosus
B. Wagner1, F. da Silva Nardi1, S. Schramm1, T. Kraemer2, J. Dürig3, C. Bade-Döding2, P. A. Horn1, U. Dührsen3, H. Nückel3, V. Rebmann1;
1
Institute for Transfusion Medicine, University Hospital Essen, Essen, Germany, 2Institute for Transfusion Medicine, MH Hannover, Hannover, Germany, 3Department of Hematology, University Hospital
Essen, Essen, Germany.
P. Zdziarski;
Dept Clin Immunol Lower Silesian Center for Cellular Transplantation, Wroclaw, Poland.
D. Kouniaki1, V. Kitsiou1, T. Athanassiades1, K. Tarassi1, E. Tziotziou1, P. Nisioti1, S. Dendrinos2, G. Kreatsas2, C. Papasteriades1, A. Tsirogianni1;
1
Immunology-Histocompatibility Dept., Evangelismos Hospital, Athens, Greece, 22nd Department of Obstetrics and Gynecology, Aretaieio Hospital, Medical School, National & Kapodistrian University of
Athens, Athens, Greece.
Q. Li1, H. Zhu1,2, H. Luo1,2, D. Karp1, X. Zuo2, E. K. Wakeland1;
1
University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Xiangya Hospital, Central South University, Changsha, China.
Association of Human Leukocyte Antigen with Chronic Periodontitis Patients in Libya
A. O. Daeki1,2,3;
1
Faculty of medicine, Tripoli, Libyan Arab Jamahiriya, 2Tripoli University, Tripoli, Libyan Arab Jamahiriya, 3Ministry of Higher Education and Scientific Research, Tripoli, Libyan Arab Jamahiriya.
Track E – Other
Chairpersons: Martina Prelog; Würzburg, Germany / Antonella Prisco; Napoli, Italy
P.E.04.01
Arterial stiffness is associated with cytomegalovirus-specific senescent CD8+ T cells
P.E.04.03
Senescent T cells acquire innate-like functions regulated by NKG2D signaling
P.E.04.02
Ageing and damaged red blood cells display novel, distinct molecular patterns that can engage different immune receptors
P.E.04.04
The overall age-related increase of human Cytomegalovirus-specific T cell frequencies has been exaggerated as a result of limited protein target inclusion
P.E.04.05
Role of Immune System in Muscle Regeneration
P.E.04.06
Is there an increased frequency of autoantibodies in aging?
P.E.04.07
HCMV-mediated memory-inflation towards a HLA-C-restricted epitope
P.E.04.08
Population variation in anti-S. aureus IgG isotypes influences surface protein A mediated immune subversion
P.E.04.09
Fate mapping of hematopoietic stem cell activity in situ
P.E.04.10
Atypical chemokine receptor 4 regulates CCR7-dependent migration of dendritic cells from the skin at rest and under inflammatory conditions
P.E.04.11
Evaluation of tumour immune response in immune cells to genotoxic drugs and environmental agents using systems immunological methods
P.E.04.12
Immunization before the onset of immunosenescence? IgG responses and B-cell subset kinetics following vaccination in pre-elderly
P.E.04.13
The expression profile of small noncoding RNAs in human CD4+ T cells in centenarians as compared to individuals in selected age groups
P.E.04.14
Age-related change of cytokines and Th1/Th2 ratio in healthy individuals in Korea
J. Youn1, H. Yu1,2, S. Park1, E. Shin2;
1
Yonsei University College of Medicine, Seoul, Korea, Republic of, 2Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea, Republic of.
Wednesday
P.D.27.14
B. I. Pereira, M. Vukmanovic-Stejic, A. Akbar;
H. Cao1, M. Moss1, B. Minter1, H. Wassall1, M. Forrester1, D. Tampakis2, W. Pickford1, L. Hall1, P. Crocker3, L. Erwig1, M. Vickers1, R. Barker1;
1
Institute of Medical Sciences, Aberdeen, United Kingdom, 2Centre for Biological Engineering, Loughborough, United Kingdom, 3College of Life Sciences, Dundee, United Kingdom.
M. Bajwa1, S. Vita2, H. Smith3, D. Thomas1, P. Sansoni4, R. Vescovini4, F. Kern1;
1
Brighton and Sussex Medical School, Division of Medicine, Brighton, United Kingdom, 2University Sapienza of Rome, Department of Public Health and Infectious Diseases, Rome, Italy, 3Brighton and
Sussex Medical School, Division of Primary Care and Public Health, Brighton, United Kingdom, 4University of Parma, Dipartimento di Medicina Interna e Scienze Biomediche, Parma, Italy.
S. Al-Dabbagh1, J. S. McPhee, N. Al-Shanti;
Manchester Metropolitan University, Manchester, United Kingdom.
A. Martinez-Rodriguez1, E. Vergara1, A. Suarez-Cordero1, I. Alcalá1, M. J. Baz2, M. L. Vargas1;
1
Service of Inmunology. Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain, 2Service of Biochemistry. Hospital Comarcal Llerena., Badajoz, Spain.
L. Hosie1, A. Pachnio1, S. Riddell2, P. Moss1;
1
Cancer Sciences, University of Birmingham, Birmingham, United Kingdom, 2Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
J. Whitehouse1, Y. Yamaguchi1, A. Flaxman1, C. Rollier2, M. K. O’Shea1,3, J. Fallowfield4, M. Lindsay4, F. Gunner4, K. Knox5, D. H. Wyllie1,6;
1
Jenner Institute, University of Oxford, Oxford, United Kingdom, 2Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom, 3Department of Academic Medicine, Royal
Centre for Defence Medicine, Birmingham, United Kingdom, 4Environmental Medicine and Science Division, Institute of Naval Medicine, Gosport, United Kingdom, 5Nuffield Department of Primary Care
Health Sciences, Oxford, United Kingdom, 6Nuffield Department of Medicine, Department of Microbiology, John Radcliffe Hospital, Oxford, United Kingdom.
K. Busch1, K. Klapproth1, T. Höfer2, H. R. Rodewald1;
1
Division of Cellular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
R. A. M. Wilson, S. A. Bryce, R. J. Nibbs;
Institute of Infection, Immunity and Inflammation, Glasgow, United Kingdom.
P. Pushparaj, M. Rasool, M. Naseer, K. Gauthaman;
King Abdulaziz University, Jeddah, Saudi Arabia.
M. van der Heiden1,2, G. Berbers1, M. C. van Zelm3, A. M. Boots2, A. Buisman1;
1
Center of Infectious Disease Control, National Institute of Public Health and the Environment (RIVM), Bilthoven, Netherlands, 2Department of Rheumatology and Clinical Immunology at the University
Medical Center Groningen, Groningen, Netherlands, 3Department of Immunology, Erasmus MC, Rotterdam, Netherlands.
J. E. Frackowiak1, K. A. Lisowska1, A. Jasiulewicz1, A. Mikosik1, K. Ruckemann-Dziurdzinska2, Z. Wicik3, R. Bartoszewski4, J. M. Witkowski1;
1
Department of Pathophysiology, Medical University of Gdansk, Gdansk, Poland, 2Department of Pathology and Experimental Rheumatology, Medical University of Gdansk, Gdansk, Poland, 3Department
of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland, 4Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Gdansk,
Poland.
W. Chang, E. Kim, Y. Lim, D. Yoon, J. Son, J. Lee;
Korea National Institute of Health, Korea Center for Disease Control and Prevention, Cheongju, Chungcheongbuk-do, Korea, Republic of.
117
P.E.04.15
Chronic effects of strength training on inflammation mediated by high-sensitive C-reactive protein and nitric oxide in hypertensive elderly women
P.E.04.16
How the immune system faces seasonal threats
F. F. Dantas1, L. R. Castellano2, J. R. Souza2,3, M. S. Brasileiro-Santos1,4, A. C. Santos1,4;
1
Programa Associado de Pós-Graduação em Educação Física UFPB/UPE, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil, 2Human Immunology Research and Education Group, Escola Técnica
de Saúde da UFPB, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil, 3Departamento de Fisiologia e Patologia, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa,
Paraíba, Brazil, 4Departamento de Educação Física, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil.
M. B. Whalen1, G. Sole1, M. Steri1, V. Serra1, M. Marongiu1, M. Dei1, S. Lai1, F. Virdis1, V. Orru’1, E. Fiorillo1, F. Cucca1,2;
1
Institute of Genetic and Biomedical Research of the National Research Council, Cagliari, Italy, 2University of Sassari, Sassari, Italy.
P.E.05 Reproductive Immunology
Chairpersons: Claytus Davis; Beer Sheva, Israel / Nardhy Gomez-Lopez; Detroit, United States
Wednesday
118
P.E.05.01
Immunosuppressive CD71+ erythroid cells in the cord blood of patients who underwent term and preterm labor
P.E.05.02
Association between follicular fluid levels of chemokines with implantation potential of the human embryo in natural cycle in vitro fertilization
P.E.05.03
Cytokine gene polymorhisms and endometeriosis in a Hellenic population
P.E.05.04
Functional impairment of CMV-reactive cellular immunity during pregnancy
P.E.05.05
Association of IL-17A and IL-17 F gene polymorphisms with recurrent pregnancy loss in Iranian women
P.E.05.06
Immunostimulation of placental cells by Fcγ fragments: potential replacement of IVIg therapy in recurrent abortions
P.E.05.07
Peripheral blood microparticles` influence on THP-1 molecules` expression in case of healthy pregnancy and preeclampsia
P.E.05.08
A Study of Natural Autoantibodies in Ectopic Pregnancy (Preliminary results)
P.E.05.10
Influence of soluble factors derived from placenta on phenotype of THP-1 cells cultured on Matrigel
P.E.05.11
Immunomodulatory treatment with low-dose prednisone in women with spontaneous recurrent miscarriage
P.E.05.12
Immunology of human reproduction
P.E.05.13
Fetal innate immunity: the embryonic response to direct MVM viral infection in utero
P.E.05.14
Treg/Th17 balance in murine embryo implantation and pregnancy
P.E.05.15
Fetal innate immunity: mid-trimester response to direct LPS challenge in utero
Y. Xu1, R. Romero1,2,3, R. Unkel1, D. Miller1, S. S. Hassan4,1, N. Gomez-Lopez4,1;
1
Perinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, United States, 2University of Michigan, Ann Arbor, MI, United States, 3Michigan State University, East Lansing, MI, United States, 4Wayne
State University, Detroit, MI, United States.
T. Chaushev1, V. Staykov1, T. Batsalova2, G. Stamenov1, B. Dzhambazov2;
1
Nadezhda Fertility Clinic, Sofia, Bulgaria, 2Plovdiv University, Plovdiv, Bulgaria.
I. Strergioudas1, V. Dalavitsou2, A. Gerofotis3, G. Makedos1, I. Prapas1, S. Metallidis3, M. Daniilidis3;
1
Third Obstetrics and Gynaecological Clinic, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece, 2Immunogenetics Research Laboratory, 1st Department of Internal Medicine,
Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece, 3First Department of Internal Medicine, Ahepa University Hospital, Aristotle University of Thessaloniki, Thessaloniki,
Greece.
E. Reuschel1, S. Barabas2, H. Bendfeldt2, L. Deml2, K. Böckl2, B. Seelbach-Göbel1;
1
Department of Obstetrics and Gynecology, University of Regensburg, Hospital of the Barmherzige Brueder, Clinic St. Hedwig, Regensburg, Germany, 2Lophius Biosciences GmbH, Regensburg, Germany.
S. Najafi1, H. Hadinedoushan2, G. Eslami2;
1
Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of, 2Yazd University of Medical Sciences, Yazd, Iran, Islamic Republic of.
E. Drougkas, C. Dimitropoulos, I. Athanassakis Irene;
Department of Biology, University of Crete, Heraklion, Greece.
V. A. Mikhaylova, O. M. Ovchinnikova, S. A. Selkov, D. I. Sokolov;
FSBSI The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott, Saint-Petersburg, Russian Federation.
T. G. Konstantinidis1,2, T. Christina1, E. Kontomanolis3, M. Aslanidou1, T. Gkioka1, G. Romanidou4,2, A. Tsirogianni5, G. Kampouromiti1, P. Tsikouras3;
1
Biopathology Laboratory, University General Hospital of Alexandroupolis, Alexandroupolis, Greece, 2MRB Center, Drama Greece, Drama, Greece, 3Department of Obstetrics and Gynecology, Democritus
University of Thrace, Alexandroupolis, Greece, Alexandroupolis, Greece, 4Nephrology Department, Nephrology Department, Democritus University of Thrace, Alexandroupolis, Greece, Alexandroupolis,
Greece, 5Immunology-Histocompatibility Department. Evangelismos General Hospital of Athens, Athens, Greece.
T. Lvova;
The D.O.Ott Research Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation.
J. Carbone, M. Arraya, O. Gonzalez, J. Navarro, J. Gil, E. Fernandez-Cruz;
B. Onderova;
MEDIREX, a.s., Bratislava, Slovakia.
I. Rostovsky, C. Davis;
Ben-Gurion University of the Negev, Beer Sheva, Israel.
B. Polese1, V. Gridelet1, E. Araklioti1, C. Legrand1, C. Munaut1, N. Lédée2, H. Martens1, S. Perrier d’Hauterive1, V. Geenen1;
1
University of Liège, Liège, Belgium, 2University Paris Diderot, Paris, France.
N. Cohen, I. Rostovsky, C. Davis;
Ben-Gurion University of the Negev, Beer Sheva, Israel.
Author Index
Authors
Author Index
119
Author Index
Authors
120
A
Aaarão, T.: P.B.35.08
Aaron, S.: P.D.16.11
Aarsland, D.: P.B.07.01
Aarts, C. E.: P.C.01.09
Abajyan, A.: P.B.37.07
Abate, W.: P.C.19.07, P.C.23.07
Abbadi, M.: P.B.40.09, P.D.27.02
Abbadi, M.-C.: P.B.30.17, P.B.30.18
Abbas, A. K.: P.A.16.03
Abbasova, V.: P.B.24.10
Abbate, I.: P.A.17.04
Abbotts, B.: P.D.01.14
Abbühl, B.: P.D.24.09
Abd El Aziz, S.: P.B.16.15
Abdel Hay, R.: P.C.06.16
Abdelhedi, R.: P.B.41.03
Abdellaoui, N.: P.B.30.17
Abdelmouleh, N.: P.B.41.03
Abdirama, D.: P.B.19.13
Abdolmaleki, S.: P.D.19.05
Abdulaal, W.: P.B.37.23
Abed Maillard, S.: P.C.03.13
Abel, A.: P.A.04.05
Abel, E.: P.D.23.01
Abel, S.: P.B.17.15
Abendroth, A.: P.B.24.18
Aberle, J. H.: P.D.19.11
Abid, L.: P.B.41.03
Abidi, A.: P.A.05.08, P.B.20.17
Abir, K.: P.B.01.07
Abo Eiela, M.: P.C.06.16
Abolfazli, R.: P.B.21.17
Abooali, M.: P.C.08.14
Abossolo, B.: P.B.03.12
Abou-Jaoudé, W.: P.A.14.02
Aboutaleb, N.: P.D.01.12
Abraham, R. S.: P.B.18.05
Abram, C.: P.C.21.04
Abrantes, J.: P.C.23.05, P.D.12.10
Abrignani, S.: P.A.02.08, P.A.05.07, P.A.26.05
Abril-Gil, M.: P.B.38.22
Abruzzese, M.: P.B.40.18
Abylgazinova, N.: P.B.38.17
Acebes-Huerta, A.: P.C.02.17, P.C.18.03
Achar, P.: P.A.09.05
Achatz-Straussberger, G.: P.A.16.03
Acosta Rodriguez, E.: P.B.16.16
Acuff, N. V.: P.C.01.21
Acuña, E.: P.B.21.10
Aczel, T.: P.B.22.11
Adachi, Y.: P.C.14.14, P.D.16.04
Adalid-Peralta, L.: P.B.03.22
Adam, D.: P.A.08.14
Adam, I.: P.B.09.17
Adams, D. H.: P.B.02.03, P.C.17.14, P.C.17.16
Adams, E. J.: P.A.08.03
Adamski, J.: P.B.41.07
Adarichev, V. A.: P.B.22.22
Adegnika, A.: P.B.03.12
Adeli, M.: P.B.18.05
Adelmann, K.: P.B.20.15
Aderem, A.: P.C.24.13
Adilbayeva, A.: P.B.22.22
Adjali, O.: P.B.42.16
Adjobimey, T.: P.B.03.08
Adler, T.: P.B.18.20
Admon, A.: P.A.03.18, P.D.27.06
Adotévi, O.: P.A.04.02
Adoue, V.: P.A.06.10
Adrienn, G.: P.B.14.14
Adriouch, S.: P.A.16.15, P.C.17.06
Aerts, J. L.: P.D.06.22
Aerts, S.: P.D.13.02
Afanasyeva, A. A.: P.B.24.25
Afanasyeva, M. A.: P.B.28.09
Afkham, A.: P.A.05.06, P.A.14.11
Afonina, I.: P.B.10.24
Agace, W.: P.B.20.18, P.C.01.04
Agace, W. W.: P.A.23.08
Agalave, N.: P.B.24.07
Agaugue, S.: P.B.40.01
Ageeva, E. S.: P.B.24.24, P.B.24.25
Aggarwal, N.: P.C.08.01
Aggeletopoulou, I.: P.A.14.17, P.B.34.05
Agger, E.: P.D.20.15
Aghaallaei, N.: P.A.11.11
Aghapour, M.: P.B.05.11, P.B.05.12, P.B.05.18,
P.B.19.04, P.D.12.09, P.D.16.01
Aghasadeghi, M.: P.D.15.07
Aghebati, L.: P.A.14.12
Aghebati Maleki, A.: P.D.09.14
Aghebati Maleki, L.: P.A.19.03, P.A.19.04,
P.A.19.05, P.B.13.02, P.D.09.14
Aghebati Maleki, R.: P.B.13.02
Agnandji, S.: P.B.03.12
Agnarsson, B. A.: P.B.09.24
Ágnes, B.: P.C.15.04
Agostini, C.: P.B.31.02
Agrati, C.: P.A.17.04, P.B.15.17, P.B.31.10,
P.C.03.03, P.C.04.03, P.C.04.12
Agrogianni, M.: P.B.24.21
Agua-Doce*, A.: P.B.21.07
Agüera Morales, M.: P.D.25.01, P.D.25.18
Agüero, R.: P.B.16.04, P.C.02.15
Aguilar, J.: P.A.13.05
Aguilar-Cazares, D.: P.B.39.14
Aguillon, J.: P.A.10.06
Aguiló, A.: P.B.04.02
Aguiló Cucurull, A.: P.B.18.18
Agustinho, D. P.: P.C.24.16
Ahammer, L.: P.A.03.11
Ahern, P.: P.B.20.15
Ahlers, J.: P.B.21.04
Ahmad, A.: P.C.10.13
Ahmad, F.: P.C.02.12, P.C.18.11
Ahmad, R.: P.B.08.02, P.E.03.17
Ahmadi, H.: P.C.05.13
Ahmadi, S. M.: P.A.23.20
Ahmadi-Erber, S.: P.A.23.18
Ahmed, R. S.: P.D.08.02
Ahmetlić, F.: P.B.13.03
Ahonen, M.: P.D.06.08
Ahrens, S.: P.B.23.10
Ahrenstorf, G.: P.B.31.18, P.C.18.11
Ahuja, V.: P.A.24.14
Ai, Y.: P.D.14.20
A. Iancu, S. Ciulean,: P.D.16.03
Aina, R.: P.B.11.11, P.B.38.05
Airoldi, I.: P.A.08.13
Airouche, S.: P.D.05.04
Ait-Younes, S.: P.B.28.06
Aitzhanova, R. M.: P.B.22.22
Aizea, M.-K.: P.D.22.17
Ajami, A.: P.B.27.03
Ajdary, S.: P.B.27.17
Akalın, H.: P.B.01.08, P.B.01.09, P.B.01.10
Akamine, E. H.: P.B.31.03
Akarsu, C.: P.B.28.05
Akbar, A.: P.E.04.03
Akbar, A. N.: P.C.11.10
Akbari, M.: P.D.12.09
Akbulut, Z.: P.A.01.12, P.C.12.14
Akcali, C.: P.C.04.13
Akdeniz, F. T.: P.A.01.12, P.C.12.14
Akdeniz, N.: P.B.12.08, P.B.27.04
Akhdar, A.: P.D.26.09
Akhmetzyanova, I.: P.D.16.22
Akhtar Khan, N.: P.E.03.05
Akiibinu, M. O.: P.D.10.13
Akkad, D. A.: P.D.10.12
Akkurt, Z. M.: P.B.37.05
Akpınar, S.: P.B.04.20
Aksu, G.: P.A.14.19, P.B.05.20, P.B.19.01,
P.B.30.20, P.C.01.07
Aksyonova, I.: P.A.21.14, P.B.31.07
Aktan, M.: P.B.40.04, P.B.40.05
Akulich, K. A.: P.A.12.02
A. Kıykım, A.: P.B.04.21
Akyol, G.: P.B.04.20
Alaez-Alvarez, L.: P.D.06.21, P.D.19.16
Alaguthurai, T.: P.C.13.18
Ala-Kokko, T.: P.D.08.15
Alan, K. J.: P.D.22.17
Alanio, A.: P.C.04.01
Al-Ansari, A.: P.B.28.01
Alansari, A.: P.A.15.07
Alansary, D.: P.A.15.04
Alarcon, B.: P.A.13.16, P.A.28.19
Albarède, F.: P.B.22.07
Albarrán-Planelles, C.: P.B.10.11
Albayrak, Ö.: P.C.12.14
Albegova, D. Z.: P.D.10.08
Albeidaq, A.: P.A.10.08
Alberghini, F.: P.A.27.03
Alberola-Ila, J.: P.A.11.10
Albert, M. L.: P.B.01.02, P.C.23.06, P.D.08.10
Albini, A.: P.C.10.06, P.C.10.07
Albogami, S.: P.B.24.23
Albrecht, R. A.: P.C.13.14
Albuquerque, M. M.: P.B.17.03
Alcain, J.: P.B.40.14
Alcalá, I.: P.B.09.09, P.E.04.06
Alcalde, A.: P.C.09.17
Alcaraz, A.: P.A.18.09
Al-Dabbagh1, S.: P.E.04.05
Aldajani, W. A. S.: P.C.06.09
Aldawsari, F.: P.A.04.20
Aldinucci, A.: P.B.34.19
Alekseev, A.: P.A.14.16
Alekseeva, L.: P.B.02.09
Alenda, R.: P.B.21.14, P.B.34.07
Aleshina, G. M.: P.C.09.08
Alessi, M.-C. C.: P.A.23.05
Alexa, A.: P.A.12.12
Alexaki, V.-I.: P.C.17.17
Alexander, T.: P.A.02.12
Alexandre-Pires, G.: P.C.01.03, P.C.19.13
Alexandrova, M.: P.B.31.15
Alexeev, L.: P.A.20.21
Alexeeva, I.: P.E.03.22
Alexeeva, L.: P.B.24.20
Alexiou, C.: P.E.02.05
Alfaro, C.: P.A.09.01
Alfayate-Miguélez, S.: P.B.30.06, P.B.30.10
Alferink, J.: P.C.20.05
Alfonso-Pérez, M.: P.B.14.20
Al-Ghaithi, H.: P.A.15.07
Alhaj mahmoud, S.: P.B.28.13
Alhamadani, A. H.: P.B.19.14
Al-Hassi, H. O.: P.C.20.03
Al-Hassi, H.: P.D.16.07
Al-Herz, W.: P.B.18.05
Ali, S.: P.C.24.04
Alici, E.: P.C.02.22
Alimoghadam, K.: P.D.06.20
Alimohammadian, M. H.: P.B.27.17
Alipour, H.: P.D.19.05
Alivernini, S.: P.B.09.23
Al-Jabri, A. A.: P.B.31.08
Aljama Garcia, P.: P.D.25.01, P.D.25.18
Aljurayyan, A.: P.A.09.05
Allacher, P.: P.D.24.09, P.D.24.10
Allan, S. M.: P.B.24.22
Allard, M.: P.D.15.11, P.D.25.06
Allen, E.: P.B.02.22
Allie, N.: P.B.16.05
Alliouche Kerboua, A.: P.B.05.09, P.B.19.16
Allonsius, C.: P.C.21.15
Allouch, M.: P.B.10.06
Almacioglu, K.: P.C.06.17
Al-Mahruqi, S. H.: P.B.31.08
Al-Maskari, U.: P.A.15.07
Almeida, C. R.: P.C.10.19, P.D.23.10
Almeida, I. C.: P.B.17.13
Almeida, M. E.: P.B.19.18
Almeida, R. P.: P.B.17.10
Almeida, S.: P.C.21.18
Almeida, S. L.: P.B.09.01
Almeida, T.: P.C.23.05
Almenar, L.: P.D.25.02
Almer, S.: P.C.17.12
Almer Boström, E.: P.C.17.12
Almer Boström, P.: P.C.17.12
Al-Mughales, J. A.: P.B.08.17
Alnahas, S.: P.A.06.12, P.B.38.10
Alomashi, G. B.: P.B.19.14
Alonso, B.: P.B.34.02
Alonso, C.: P.A.17.01
Alonso, R.: P.D.25.07
Alonso Arias, R.: P.A.02.07, P.B.42.01, P.E.02.13
Alonso Fernández, M.: P.D.02.20
Alonso-Garcia, L.: P.B.04.04
Alpdundar, E.: P.C.04.13, P.C.21.08, P.D.20.08
Alrayahi, I. A.: P.C.04.16
Alrefai, H.: P.A.10.14
Al-saadi, H. A.: P.E.03.03
Al-Saati, T.: P.A.19.19
Alsadeq, A.: P.A.09.14
Al Saeedi, M.: P.B.35.13
AlSaieedi, A.: P.D.22.01
Alsén, S.: P.A.09.06
Al-Shabany, A.: P.C.17.26
Al-Shanti, N.: P.E.04.05
Alshevskaya, A.: P.B.10.17
Al-Shukaili, A.: P.B.28.01
Alsina, L.: P.B.04.02, P.B.31.05
Altaee, O. M.: P.B.19.14
Altelaar, M.: P.A.02.15
Alter, C.: P.A.20.02
Altfeld, M.: P.C.02.09
Altomare, A.: P.B.10.19
Altomare, G.: P.B.10.19
Altorki, T. A.: P.C.05.17
Altreuter, D. H.: P.D.24.12
Alva-Murillo, N.: P.D.12.02
Alvarez, A.: P.B.31.06
Alvarez, C.: P.A.24.05, P.D.03.10
Alvarez, J.: P.B.16.21
Álvarez, J. L.: P.B.09.09
Alvarez, J. M.: P.C.12.21
Alvarez, J.: P.B.03.23
Álvarez-Argüelles, M. E.: P.B.42.01
Álvarez Cermeño, J.: P.B.34.02
Álvarez-Cermeño, J. C.: P.B.21.14, P.B.34.07,
P.B.34.10
Alvarez de la Sierra, D.: P.B.04.17
Álvarez de Mon, M.: P.C.11.01
Álvarez Doforno, R.: P.B.19.15
Alvarez-Dominguez, C.: P.D.06.21, P.D.19.16
Álvarez Fernández, M.: P.B.18.07
Álvarez-Lafuente, R.: P.B.34.02
Álvarez-López, M.: P.A.12.18, P.B.32.24,
P.C.02.22, P.C.21.03, P.C.06.06, P.C.18.22
Alvarez-Lopez, R.: P.B.09.21
Álvarez-Luquín, D. D.: P.B.03.22
Álvarez-Maestro, M.: P.D.15.03
Alvarez-Navarro, C.: P.D.27.06
Alvarez-Vallina, L.: P.C.07.15
Alves, J. C.: P.B.17.14
Alves, L. C.: P.B.42.11, P.D.18.17
Alves-Filho, J. C.: P.A.24.01, P.A.15.05, P.A.16.02,
P.B.09.01, P.B.17.21, P.B.32.18
Alves-Filho, J.: P.B.03.23, P.B.31.06
Al-Wasaby, S.: P.D.22.12
Amadori, M.: P.B.15.08
Amar, M.: P.C.17.07
Amara, K.: P.B.22.03
Amaral, E.: P.B.16.21
Amaral, E. P.: P.C.12.21
Amaral, F. A.: P.C.17.15
Amari, A.: P.D.15.20
Amatngalim, G. D.: P.B.12.07
Amberg, N.: P.B.10.23
Ambros, C.: P.D.09.12
Ambrosini, P.: P.C.10.10, P.C.18.01
Ambroz, K.: P.C.19.01
Amedee, J.: P.C.11.04
Amendola, A.: P.B.31.10
Ameratunga, R. V.: P.B.30.16
Amezcua, M. C.: P.B.16.16
Amich, J.: P.B.03.19
Amici, A.: P.A.25.05
Amici, S.: P.A.28.01
Amin, S.: P.B.33.15
Amir, S.: P.B.32.16
Amirghofran, Z.: P.C.05.13
Amirmoezi, F.: P.D.14.03
Amirzargar, A.: P.B.33.10
Ammassari, A.: P.A.17.04
Amôr, N.: P.C.12.10
Amorim, K. D.: P.B.17.03, P.B.42.11
Amr, K.: P.C.06.16
Amre, D.: P.C.10.13
Amri, M.: P.B.28.03
Amroun, H.: P.B.40.09, P.D.27.02
Amslinger, S.: P.A.08.03
Amu, S.: P.B.09.16
An, X.: P.B.39.01
Anastasopoulos, N.: P.B.27.20, P.C.24.01
Anastasopoulou, E. A.: P.D.14.16
Anastasopoulou, S.: P.B.34.05
Anatriello, E.: P.D.11.13
Anderle, H.: P.C.02.14
Anderluh, G.: P.C.17.10
Andersen, L.: P.A.11.14, P.A.14.18, P.A.21.09,
P.A.24.09
Andersen, P.: P.C.11.11, P.D.20.15
Anderson, G.: P.A.01.13
Anderson, M. S.: P.D.04.04
Anderson, R. P.: P.A.04.04
Andersson, Å.: P.B.22.08
Andersson, K. M.: P.B.09.16, P.B.21.02
Anderton, S. M.: P.A.06.08, P.B.34.15
Anderton, S.: P.A.25.13
Andosch, A.: P.B.11.03
Andrade, F. B.: P.C.24.10
André, S.: P.E.03.07, P.E.03.13
Andreas, M.: P.D.25.17
Andreata, F.: P.C.11.03
Andrejauskas, P.: P.B.28.08
Andrén, O.: P.C.11.15
Andres, C.: P.B.18.20
Andres, V.: P.A.04.17
André-Schmutz, I.: P.D.01.01
Andrews, R.: P.C.17.21
Andrews, S.: P.A.09.11
Andújar, E.: P.A.09.16
Anegon, I.: P.A.16.09, P.D.26.11
Anel, A.: P.D.22.12
Añez, G. A.: P.A.10.20
Anft, M.: P.C.10.14
Angelina, A.: P.B.26.12
Angelot-Delettre, F.: P.C.13.16
Angelova, O.: P.B.31.15
Angiari, S.: P.B.21.08
Angulo, I.: P.B.04.13
Ankersmit, H. J.: P.B.38.09
Annamaria, F.: P.B.22.11
Annemann, M.: P.A.24.10
Annuk, H.: P.C.13.10
Annunziato, F.: P.A.05.11, P.A.05.12, P.B.09.20,
P.B.10.02
Ansari, M. A.: P.D.11.05
Ansari, N.: P.B.17.19
Anselmo, A.: P.C.06.01
Antica, M.: P.B.40.19
Antic-Stankovic, J.: P.B.38.03
Antinori, A.: P.A.17.04
Anton, M.: P.B.05.13
Antonini, F.: P.C.11.23
Anton-Le Berre, V.: P.A.19.19
Antonova, I.: P.A.25.11, P.A.25.12
Antrobus, R.: P.A.22.13
Anuforo, O. U.: P.C.18.05
Aoki, J.: P.A.01.11
Apáti, Á.: P.C.20.09
Apoil, P.-A.: P.D.17.14
Aporta, A.: P.D.22.12
Apostólico, J. S.: P.D.20.01
Appanna, R.: P.A.18.04
Appay, V.: P.A.20.08, P.B.42.08, P.E.02.12
Appel, S.: P.C.06.19
Appelt, C.: P.A.02.06, P.A.16.08
Apresova, M.: P.C.23.15, P.C.23.16
Apta, B.: P.A.19.16
Arabian, E.: P.C.15.18
Aradottir Pind, A. A.: P.A.27.14, P.A.27.15
Aragon, L.: P.D.27.04, P.E.03.04
Araklioti, E.: P.E.05.14
Aram, J.: P.B.21.11
Aranda, A.: P.B.11.09
Aranda, F.: P.A.25.08, P.B.13.13, P.D.06.11
Aranda-Vega, F.: P.D.16.05
Arantes, A. S.: P.B.32.20
Arantza, A.: P.D.22.17
Araújo, A. D.: P.A.06.02, P.B.17.14
Araujo, C.: P.B.16.16
Araújo, E. F.: P.B.03.07, P.C.20.14
Araujo, L. P.: P.A.15.14
Araújo-Pires, A. C.: P.A.06.09
Araújo Souza, P.: P.A.28.12
Aravena-Madariaga, O. A.: P.A.10.06
Arbogast, F.: P.A.20.17
Arboleya, S.: P.B.07.16
Arce, F.: P.D.23.12
Arce-Paredes, P.: P.B.08.19
Arce-Sillas, A.: P.B.03.22
Arck, P. C.: P.A.06.17
Arcos, M. J.: P.C.02.03
Ardesjö Lundgren, B.: P.D.04.04
Arens, R.: P.A.17.03, P.A.23.09
Arese, P.: P.B.03.24
Arias, C.: P.B.19.10
Arias, J.: P.D.03.10
Arias, M.: P.C.09.17
Aribi, M.: P.A.04.01, P.C.11.16, P.E.03.05
Aricò, M.: P.B.04.22, P.D.14.23
Aringer, I.: P.A.24.07, P.B.05.14, P.B.23.19
Ariza, A.: P.B.12.11
Armendariz Borunda, J.: P.B.37.25
Armiger, N.: P.D.16.05
Armiger-Borràs, N.: P.A.25.08
Arnal, C.: P.B.34.10
Arndt, C.: P.D.14.12
Arndts, K.: P.B.03.10
Arnemo, M.: P.D.02.18
Arnold, B.: P.D.07.13
Arnold, J.: P.A.20.17
Arnold, S.: P.B.02.02
Arnold, T.: P.C.22.07
Arnold-Schrauf, C.: P.C.13.05
Aron-Wisnewsky, J.: P.E.03.07
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Arora, J.: P.B.18.04
Arostegui, J.: P.B.05.13
Arra, A.: P.A.07.01
Arra, C.: P.D.14.15
Arraya, M.: P.B.09.08, P.B.30.22, P.B.31.20,
P.D.25.03, P.D.25.07, P.E.05.11
Arrazola, M. A.: P.D.09.13
Arriaga Pizano, L.: P.C.03.20
Arribas-García de León, M.: P.D.23.13
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Arroyo, J.: P.B.16.04
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Arruda, L. C.: P.D.01.07
Arruda-Silva, F.: P.C.01.19
Arsenijević, A.: P.B.23.17, P.B.07.04
Arsenijevic, N.: P.B.07.04, P.B.32.03, P.B.41.14,
P.C.02.07, P.C.02.10, P.E.03.15
Arslan, B.: P.B.03.19
Arslanian, C.: P.B.30.02
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Arstila, T. P.: P.A.11.06, P.A.25.14, P.B.42.02,
P.B.35.10
Artan, R.: P.B.04.01
Arteche, A.: P.B.40.16
Artinger, K.: P.A.24.07, P.B.05.14, P.B.19.02,
P.B.23.19
Artukovic, M.: P.B.09.04
Artwohl, M.: P.D.16.16
Aru, B.: P.A.01.12, P.C.12.14
Aruasa, W. K.: P.B.02.13
Arul Nathan, A.: P.D.02.08
Arytm, J.: P.D.18.09
Asam, C.: P.D.05.03
Asaoka, T.: P.C.06.11
Asbach, B.: P.D.19.07
Asbach-Nitzsche, A.: P.B.16.06
Aschenbrenner, D.: P.A.05.10
Aschermann, I.: P.B.35.14
Ascierto, P. A.: P.C.15.05
Asehnoune, K.: P.C.18.16
Asensio, E.: P.B.16.04
Asensio-Montañés, E.: P.C.02.15
Asgarian-Omran, H.: P.D.19.05
Asgarova, A.: P.C.13.16
Ashino, Y.: P.D.08.13
Ashiru, O.: P.D.15.03
Ashjaei, K.: P.B.25.20
Ashrafi, M.: P.C.15.09
Asık, G.: P.A.02.14, P.A.03.14, P.E.01.02

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