Tuesday - Experimental Biology

Transcription

TUESDAY, APRIL 23
Anatomy
956. ANATOMY EDUCATION
Poster
Tue. 7:30 am—Boston Convention & Exhibition Center,
Exhibit Halls A-B
Presentation time: 12:30 pm-2:00 pm
A229 956.1
Head to head: the role of competition in
undergraduate education. S.E. Van Nuland, V.A. Roach, T.D.
Wilson and D.J. Belliveau. Sch. of Hlth. Sci., Univ. of Western
Ontario.
A230 956.2
Comparison between student desired grades
and actual final grades in undergraduate human anatomy. S.
Dunham. Indiana Univ.
A231 956.3
Student peer review and self-reflection in
the gross anatomy laboratory: identifying student perceived
strengths and areas for improvement. A. Edmondson, J.E.
Mackey, R. Shelley and C. Nichols. Med. Col. of Georgia,
Georgia Hlth. Sci. Univ.
A232 956.4
A comparison of medical student and
undergrad study skills in anatomy lab courses. J.B. Barger
and P. Husmann. Indiana Univ. and Ashland Univ., OH.
A233 956.5
The effect of training on individuals’ interactions
with visual data. L.A. Pfaff, K. Colliard and A. Zumwalt.
Boston Univ.
A234 956.6
Training increases subjects’ fixation time
on cognitively salient locations. K. Colliard, L. Pfaff and A.
Zumwalt. Boston Univ.
A235 956.7
Relationship between spatial abilities and
three-dimensional synthesis of structures. J. Langlois, Y.
Dagenais, R. Lemieux, M. Martin, M. Lecourtois, E. Yetisir,
G. Bergeron, S. Hamstra and G.A. Wells. Hosp. Ctr., Univ. of
Sherbrooke and Univ. of Ottawa, Canada.
A236 956.8
Relationship between spatial abilities and
cross-sectional drawings. J. Langlois, Y. Dagenais, C.
Bellemare, R. Lemieux, M. Martin, M. Lecourtois, E. Yetisir,
G. Bergeron, S. Hamstra and G.A. Wells. Sherbrooke Univ.
Hosp. Ctr., Univ. of Sherbrooke, Canada and Univ. of Ottawa.
A237 956.9
Top-down influences on visuospatial human
anatomy comprehension. K. Glena, M. Johnson and N.
Nguyen. Univ. of Western Ontario.
A238 956.10 Exploring the learning environment in a
medical school anatomy course: does group emotional
intelligence affect team performance? S.G. Porter, M. Holman,
N. Lachman and W. Pawlina. Mayo Med. Sch. and Mayo Clin.
A239 956.11 Performance in medical gross anatomy as a
predictor of USMLE Step 1 scores. D. Fletcher and D. Musick.
Brody Sch. of Med. at East Carolina Univ.
A240 956.12 Methods for the teaching of gross anatomy: a
qualitative look at the use of cadaver dissection, prosection,
plastination, and computer-aided technology as effective
methods. L.J. Day, M. Goldberg, E. Molloy, K.C. Moran and
C. Rocco. Northeastern Univ.
A241 956.13 Integrative online/onsite system enhances
histology learning in medical education. D.F. Curcio, E.S.
Yonamine and M.D. Barros. Santa Casa Sch. of Med. Sci.,
São Paulo.
A242 956.14 Types of tracheal submucosal glands:
implications of literature controversy. M.D. Barros, A.P. Landim,
A.C.M. Dobre, J.D.B. Andreotti, D.F. Curcio and A.L. Duarte.
Santa Casa Sch. of Med. Sci. and São Camilo Univ. Ctr., São
Paulo.
A243 956.15 Assessing the value of clay modeling as an
effective adjunct to human donor dissection. J.A. Rosentsveyg,
J. Patel, T. Adar and S. Marquez. SUNY Downstate Med. Ctr.
A244 956.16 The new anatomist: preparing to teach in an
integrated medical curriculum. G.M. Sorrentino. Hofstra North
Shore-Long Island Jewish Sch. of Med.
A245 956.17 Human structure in 7 weeks: one approach
to providing foundational anatomical competency in an era
of compressed medical school curricula. N.L. Halliday, D.
O’Donghue and B. Thompson. Univ. of Oklahoma Col. of
Med.
A246 956.18 The integration of osteology, radiology, and
surface anatomy into a clinical skills 101 course for first-year
medical students. B.F. Giffin, D.J. Lowrie, D. Pettigrew and A.
Gunderson. Univ. of Cincinnati Col. of Med.
A247 956.19 Integrating geriatrics with anatomy: an
educational collaboration between basic science and primary
care. K.T. Kleber, M. Young and A. Zumwalt. Boston Univ.
Sch. of Med. and Boston Med. Ctr.
A248 956.20 Teaching oncology residents anatomy: a
multidisciplinary (MDT) approach. L. D’Souza, J. Jaswal, M.
Johnson, F. Chan, K.Y. Tay, K. Fung and D. Palma. Western
Univ., London Hlth. Sci. Ctr. - Victoria Hosp. and London Reg.
Cancer Prog., Canada.
A249 956.21 Physician assistant anatomy education: does
prior anatomy experience predict performance? C.E. Terhune,
B.Q. Melcher and A.B. Taylor. Duke Univ. Sch. of Med.
A250 956.22 Addressing common and specific educational
goals of the medical illustration discipline-based anatomical
courses that partially overlap with system-based modules in
the medical school curriculum. C. Stefan, W.M. Andrews and
S.J. Harrison. Med. Col. of Georgia and Col. of Allied Hlth. Sci.
at Georgia Regents Univ.
A251 956.23 A roadmap for survey design in anatomy
education research. K.A. Metzger and R. MacKay. Hofstra
North Shore-Long Island Univ. Sch. of Med. and Hofstra Univ.
A252 956.24 An overview of study methodology and
knowledge retention in veterinary anatomy on DVM students.
C. Trincado, J.C. Gutierrez and L. Freeman. Virginia Tech
Col. of Vet. Med.
A253 956.25 Dissection of the supra-clavicular region, a
plaster of the B. cuneo’s collection. P. Le Floch-Prigent. Med.
Sch., UFR Med. PIFO, Versailles-Saint Quentin Univ., France.
A254 956.26 An enlarged anatomical model of the eye in
papier mâché by the Doctor Auzoux. P. Le Floch-Prigent.
PIFO Med. Sch., Versailles-Saint Quentin Univ., France.
A255 956.27 Anatomy at West Virginia University: 18672012. J.L. Culberson. West Virginia Univ.
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ANATOMYTUESDAY
957. ANATOMY EDUCATION: ASSESSMENT,
CURRICULUM AND MENTORING
Poster
Exhibit Halls A-B
A256 957.1
Reflective writing highlights improved student
metacognition in an upper level undergraduate anatomy
course. V.D. O’Loughlin and L.M. Griffith. Indiana Univ. and
Central Michigan Univ.
A257 957.2
Assessing the cultural beliefs of medical
students: impact on the cadaveric dissection experience in the
gross anatomy laboratory. R. Khalil, J. Krum, A.R. Jurjus, F.
Slaby and R.A. Jurjus. George Washington Univ. Sch. of Med.
and Hlth. Sci. and American Univ. of Beirut.
A258 957.3
What do medical students learn from the
process of dissection? H.D. Nicholson, A. Barrett and H.
Martyn. Univ. of Otago, New Zealand.
A259 957.4
Varying effects of prosection and dissection
anatomy curriculums on confidence in the clinical setting. S.
Young, C.R. Guzman, P.F. Wimmers, C.V. Byus and J.J.
Wisco. David Geffen Sch. of Med. at UCLA, UCR/UCLA,
Riverside and Brigham Young Univ.
A260 957.5
Anatomical knowledge retention in third year
medical students prior to OB/GYN and surgery rotations. R.A.
Jurjus, J. Krapf, S. Ahle, K. Brown, G. Butera, E. Goldman
and J. Lee. George Washington Univ.
A261 957.6
Medical student feedback on participating in
a combined anatomy curriculum, 2010-2012. C. Guzman, S.
Young, P. Wimmers, C. Byus and J. Wisco. David Geffen Sch.
of Med. at UCLA, UCR/UCLA Thomas Haider Prog. in Biomed.
Sci., Riverside and Brigham Young Univ.
A262 957.7
Designing effective student presentation
assignments that include thoughtful peer assessment. S.A.
Miller. Hamilton Col., NY.
A263 957.8
Opportunities in a new medical school: a
longitudinal, integrated clinical anatomy curriculum. M. Hankin,
M. Bee, W. Forbes, J. Montante, J. Eastwood, I. Hajj-Hussein,
N. Afonso, A. Poznanski, J. Venuti and D. Gould. Oakland Univ.
William Beaumont Sch. of Med.
A264 957.9
Codebook analysis of metacognitive blogs in
an anatomy learning skills course. A. Schutte. Indiana Univ.
A265 957.10 Effect of time limits during anatomy practical
exams on student performance. G. Zhang, B.A. Fenderson,
R.R. Schmidt and J.J. Veloski. Thomas Jefferson Univ.
A266 957.11 Does exam performance correlate with
perception of readiness or pretest quizzes? A. Ball, L. Belbeck,
N. Volc, P. Helli and B. Wainman. McMaster Univ., Canada.
A267 957.12 Evaluating an anatomy-specific tool for
Blooming exam questions. A.R. Thompson and V.D.
O’Loughlin. Indiana Univ.
A268 957.13 E-testing in anatomical teaching. J. Streicher.
Med. Univ. of Vienna.
A269 957.14 Statistical analysis of anatomy final examination
grades of Hungarian, German and English speaking medical
students at the Semmelweis University. A.D. Székely, S.M.
Attardi and K.A. Rogers. Semmelweis Univ., Hungary and
Western Univ., Canada.
322
A270 957.15 Correlation of student performance on team
based learning with exams in systems based first year medical
school courses. G.D. Guttmann and A. Rosales. Univ. of
North Texas Hlth. Sci. Ctr.
A271 957.16 Student perceptions and preferences of two
TBL modalities in the second year medical curriculum. J.S.
Waggoner, M.W. Braun and V. Dean O’Loughlin. Indiana
Univ.
A272 957.17 Focused preparation of anatomy and
physiology instructors for the undergraduate college and
university setting—a report on the first cohort. R. Crocker. New
York Chiropractic Col.
A273 957.18 Anatomy education in an integrated curriculum:
importance and benefits of training and evaluation of clinical
faculty. W. Rennie, K. Metzger and D. Elkowitz. Hofstra North
Shore-Long Island Jewish Sch. of Med.
A274 957.19 The intermingled history of occupational
therapy and anatomical education – a retrospective exploration.
M.A. Carroll and K.A. Lawson. Univ. of Texas at El Paso.
A275 957.20 Developing competency in communication:
medical student perceptions of patients’ knowledge of anatomy.
D. Dudenkov, J. Primus, S. Mayer, W. Pawlina and N.
Lachman. Mayo Med. Sch. and Mayo Clin.
A276 957.21 Effects of classroom structure on retention
and implementation of knowledge in students. A.M. Banda, K.
Steed, N. Schmalz, K. Ojukwu, M. Diaz, J. Padilla and J.J.
Wisco. UCLA and Brigham Young Univ.
958. ANATOMY EDUCATION: CLINICAL-BASED
APPROACHES
Poster
Exhibit Halls A-B
A277 958.1
Cadaver
presentations: an
integrative,
clinical approach to anatomy. J.W. Denham, F. Robichaud,
C.L. Abercrombie, T.E. Kwasigroch, B.M. Browe and P.J.
Monaco. Quillen Col. of Med., Mountain Home, TN.
A278 958.2
An interprofessional approach to improve
gestational outcomes. L.J. von Hagen, D. Penava, M. Johnson
and M. Mottola. Univ. of Western Ontario and Schulich Sch. of
Med. and Dent., London, Canada.
A279 958.3
The pyramidal lobe: connecting a case study
with lymphatic system topics in gross anatomical education. K.
Cassidy. Indiana Univ.
A280 958.4
Specialized anatomy electives for fourth year
medical students in preparation for residency specialties:
plastic surgery, orthopaedics, and obstetrics & gynecology.
N.S. Viscomi, S. Suprenant-Kotal, B.K. Jones, R.A. Combs
and R.W. Clough. SIU Sch. of Med. Carbondale.
A281 958.5
An interprofessional learning module on bone
marrow biopsy within the preclinical undergraduate medical
curriculum. A. Poznanski, R. McGranahan, J. Eastwood and
J. Venuti. Oakland Univ. William Beaumont Sch. of Med. and
Univ. of Michigan.
A282 958.6
An introduction to ultrasonography: a novel
teaching session for final year medical students. R. Subbu, N.
Mackay and P. Abrahams. Warwick Univ., U.K.
A283 958.7
Stereo laparoscopy: a novel approach to
resident surgical education. V. Roach, M. Mistry and T. Wilson.
Univ. of Western Ontario.
TUESDAYANATOMY
A284 958.8
Medical students perceptions of ultrasound
use for gross anatomy teaching by clinicians and anatomists.
R.A. Jurjus, K. Dimorier, K. Brown, F. Slaby, K. Calabrese
and Y.T. Liu. George Washington Univ.
A285 958.9
Ultrasound imaging the liver: a supplement to
abdominal dissection. V.H. Lee. Texas Tech Univ. Hlth. Sci. Ctr.
A286 958.10 Application of stereoscopic visualization on
surgical skill acquisition in novices. M. Mistry, V.A. Roach and
T.D. Wilson. Univ. of Western Ontario.
A287 958.11 Integration of histology and pathology in a
senior elective course curriculum. D. Cui and W. Daley. Univ. of
Mississippi Med. Ctr.
959. ANATOMY EDUCATION: COMPUTER-ASSISTED
LEARNING
Poster
Exhibit Halls A-B
A288 959.1
3D reconstructions of early heart development
as an educational resource. V.M. Piet and R.J. Cork. LSU Hlth.
Sci. Ctr., New Orleans.
A289 959.2
Taking A SecondLook™ at teaching histology –
development of a self-evaluation iPad application. M. Hortsch.
Univ. of Michigan.
A290 959.3
Online histology modules for first-year medical
students: a student to student approach. M.V.C. Butler, H.N.
Yule and K.E. Pinder. Sch. of Popul. and Publ. Hlth., Univ. of
British Columbia.
A291 959.4
Use of an audience response (ARS) in an
interactive histology laboratory. P.C. Feasel, E. Xanthos, N.
Borges and L. Ream. Wright State Univ.
A292 959.5
Guided, self-directed learning: building an
anatomy learning module for the iPad. M.L. Haugsdal and
M.A. Pizzimenti. Univ. of Iowa Carver Col. of Med.
A293 959.6
Learning human neuroanatomical structure
and function using a computer-based learning tool. A.R.
Severson and D.J. Forbes. Univ. of Minnesota Duluth.
A294 959.7
Combining
e-learning
with
practical
anatomy—a new dissection manual. L. Hirtler, M. Zauleck
and J. Streicher. Med. Univ. of Vienna and Katharinenhosp.,
Stuttgart.
A295 959.8
Anatomical animation: new frontiers in gross
anatomy instruction. D.C. Peterson and C. Robertson. Iowa
State Univ.
A296 959.9
Interactive video animations as a study guide
for the human skeleton: 1. The scapula. G.P. Casey, P.D. Oliver
and R.J. Cork. LSU Hlth. Sci. Ctr., New Orleans.
A297 959.10 The role of clinical imaging tutorials in anatomy
education. L. Smith, A. Hoover, P. Brian and M. Lazarus.
Penn State Col. of Med.
A298 959.11 Development of a virtual 3D renal corpuscle for
educational environments. J. Roth, T. Wilson and M. Sandig.
A299 959.12 Establishing the validity and reliability of
computer-based simulation for cerebral angiography using
the ANGIO Mentor Express. N. Nguyen, R. Eagleson and
S. deRibaupierre. Western Univ. and London Hlth. Sci. Ctr.,
Canada.
A300 959.13 Digital atlas for ultrasound-guided regional
never blocks of the trunk. A. Stone, M. Johnson and S.
Ganapathy. Univ. of Western Ontario Schulich Sch. of Med.
and Dent.
A301 959.14 Spatial ability and cognitive load demands
during visual learning and testing: a transcranial Doppler
ultrasound study. J. Loftus and T.D. Wilson. Univ. of Calgary/
Schulich of Med. & Dent., Univ. of Western Ontario.
960. ANATOMY EDUCATION: TEACHING METHODS
AND INNOVATIONS
Poster
Exhibit Halls A-B
A302 960.1
Evaluation of anatomy comic strips for further
production and applications. M.S. Chung. Ajou Univ. Sch. of
Med., South Korea.
A303 960.2
Cadaver lab, white boards and pedagogy:
uniting teachers, students and anatomy. N. Harper, D.A.
Morton and M.T. Nielsen. Univ. of Utah Sch. of Med. and Univ.
of Utah.
A304 960.3
Collaborative key features problems in
anatomy: assessment drives clinical decision making and
anatomical learning. M. Terrell, J. Kalmey and R. Kulesza.
Lake Erie Col. of Osteo. Med.
A305 960.4
Medical student perceptions of a radiology
tutorial in anatomy education. A. Hoover, L. Smith, P. Brian
and M. Lazarus. Penn State Col. of Med.
A306 960.5
Movement Guided Learning© as a novel
means of musculoskeletal anatomy instruction. D.C. Bentley.
Univ. of Toronto.
A307 960.6
A learning strategy for the muscles and fascial
planes of the head and neck. L.E. Sanders, D.A. Morton and
M.T. Nielsen. Univ. of Utah.
A308 960.7
Understanding human cranial nerves through
a patterned based comparative approach. J.A. Bohn, D.A.
Morton and M.T. Nielsen. Univ. of Utah.
A309 960.8
3D Atlas of Human Embryology: creating an
application as a new learning tool. B.S. de Bakker and A.F.M.
Moorman. Acad. Med. Ctr., Amsterdam.
A310 960.9
Innovative technology expands student
laboratory experience during medical gross anatomy course:
addition of iPads in lab revolutionizes how anatomy is taught.
C.L. Abercrombie, N. Yogesh, L.Q. Olive, J.A. Miller, J.W.
Denham, B.M. Browe and T.E. Kwasigroch. Quillen Col. of
Med., East Tennessee State Univ.
A311 960.10 Interactive educational touch screen panels in
anatomy laboratuary training. F. Yazar, S. Develi and B. Yalcin.
Gulhane Military Med. Acad., Turkey.
A312 960.11 Your voice sounds fine: making podcasts to
promote learning. E.W. Dewar. Suffolk Univ., MA.
A313 960.12 Teaching secular trends of human anatomy in
a novel medical school module. F. Rühli, A. Saniotis and M.
Henneberg. Univ. of Zurich and Univ. of Adelaide.
A314 960.13 Retrieval learning as a guiding tool for
prematriculation students in the study of histology. D. Cui, A.K.
Pavlov, T. Yang and J.C. Lynch. Univ. of Mississippi Med. Ctr.
A315 960.14 Peer teaching in an online histology classroom.
M. Barbeau and K.A. Rogers. Western Univ., Canada.
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ANATOMYTUESDAY
A316 960.15 Dual-lecturer-mode in teaching advanced
medical histology. J. Chen, W. Daley and D. Cui. Univ. of
A317 960.16 Anatomy academy promotes systems-based
practice among medical and undergraduate students. K.
Ojukwu, J. Padilla, M. Diaz and J. Wisco. Charles R. Drew
Univ., UCLA David Geffen Sch. of Med., Luskin Sch. of Publ.
Affairs and Fielding Sch. of Publ. Hlth. and Brigham Young Univ.
A318 960.17 Multimodal virtual anatomy learning tools
for medical education using recent advances in IT. G.
Pnnamaplam. YLL Sch. of Med., Natl. Univ. of Singapore.
A319 960.18 Evaluation of a novel online systemic human
anatomy course. S.M. Attardi and K.A. Rogers. Western
Univ., Canada.
A320 960.19 Student perceptions and effectiveness of
team-based learning in anatomy. P.B. Palmer. North Georgia
Col. & State Univ.
A321 960.20 Team-based learning in histology: lessons
learned through 7 years of experience. J.J. Brokaw and K.W.
Condon. Indiana Univ. Sch. of Med.
A322 960.21 Selected versus constructed response in
assessing anatomy knowledge?outcomes from a brief study.
C. Vasan and N. Vasan. New Jersey Med. Sch., Newark.
A323 960.22 Heart development tutorial – heart tube folding.
T.M. DeLorenzo and A. Zumwalt. Boston Univ.
A324 960.23 Evaluation of gross anatomy teaching styles at
the University of Auckland. K. Reilly, A. Wearn and P. Riordan.
Univ. of Auckland, New Zealand.
A325 960.24 Use of a Wiki as a collaborative learning tool to
promote active learning in a neuroscience course for first-year
medical students. D. Gould and M. Mi. Oakland Univ. William
Beaumont Sch. of Med.
A326 960.25 The integration of anatomy and radiology
through interactive online modules. C. Krebs, M. Fejtek, J. Hu,
M. Kazem, A. Lam, T. Liang, T. Zhang, S. Hayward and S.
Nicolaou. Univ. of British Columbia.
A327 960.26 The development of a web-based interactive
tool to complement anatomy and radiology teaching and
learning. C. Krebs, O. Oyedele, M. Fejtek and S. Tolhurst.
Univ. of British Columbia.
A328 960.27 Development of a resource for training anatomy
lab dissection techniques. J.H. Bladon and A. Zumwalt.
Boston Univ.
A329 960.28 Teaching anatomy online using retrieval
practice, 3D stereoscopic images and virtual human fly-through
videos. M.A. Kolitsky. Univ. of Texas at El Paso.
A330 960.29 A subscapular approach to the dissection of
the human brachial plexus. S. Hager, T. Backus, B. Futterman,
N. Solounias and M.C. Mihlbachler. New York Inst. of Technol.
Col. of Osteo. Med.
A331 960.30 The value of drawing in anatomical education
and its effects on academic performance and retention. S.M.
Rosa. Queen’s Univ., Canada.
A332 960.31 Dissection, prosection or both in teaching
medical gross anatomy: an old question revisited. C. Vasan, G.
Pinhal-Enfield, D. DeFouw and N. Vasan. New Jersey Med.
Sch., Newark.
324
A333 960.32 Day one: what are the possibilities for the first
day of gross anatomy courses? K.A. Metzger, D.E. Elkowitz
and W. Rennie. Hofstra North Shore-Long Island Jewish Sch.
of Med.
A334 960.33 Mobilizing clinical imaging, 3D anatomy, and
digital microscopy data for virtual reality learning objects:
HTML5 and ubiquitous learning methods. R.B. Trelease. David
Geffen Sch. of Med. at UCLA.
A335 960.34 New applications in anatomical education
using soft-embalmed cadavers. N.T. Boaz, R. Sikon, D. Sikon,
L.N. Forest and J.R. Wells. Integrat. Ctrs. for Sci. and Med.,
Martinsville, VA, Virginia Commonwealth Univ., Virginia Dept.
of Hlth. and Univ. of South Carolina Sch. of Med.
A336 960.35 The relationship between in-class written
exercise and exam performance in an allied health gross
anatomy course. K.M. Warren. Brody Sch. of Med. at East
Carolina Univ.
A337 960.36 Texas Tech System for student peer teaching
in anatomy: didactic small group sessions. B.L. Schneider and
V.H. Lee. Texas Tech Hlth. Sci. Ctr.
A338 960.37 The development and assessment of a medical
education resource that uses surface anatomy to create a link
between gross anatomy and clinical skills. J. Szymus. Queen’s
Univ., Canada.
A339 960.38 Horizontal and vertical integration of basic
sciences within the undergraduate medical curriculum:
development of high yield modules for contextual learning. A.
Poznanski, I. Niculescu, D. Gould and M. Hankin. Oakland
Univ. William Beaumont Sch. of Med. and Beaumont Hosp.,
Royal Oak, MI.
A340 960.39 Teaching medicine through media: an
interprofessional and interdisciplinary activity with neuroscience
and film. A. Poznanski, N. Afonso, K. Edwards, H. Vaughan,
N. Bulgarelli, E. Krug and D. Gould. Oakland Univ. William
Beaumont Sch. of Med. and Oakland Univ.
A341 960.40 Teaching surface anatomy through near-peer
instruction. S.J. Carp, K. Metzger and W. Rennie. Hofstra
North Shore-Long Island Jewish Sch. of Med.
A342 960.41 Video lab guides: efficacy and student
perception. H.J. Billings. West Virginia Univ. Sch. of Med.
A343 960.42 Advancing the playing field: a look at how virtual
reality can change the future of anatomy teaching learning
process. J. Duarte, C.V. Vilá, J. Vilaró and W.R. Veras. Univ.
Central del Caribe, PR.
A344 960.43 Active learning cycle of anatomy laboratory for
the Net Generation. E. De Leon and W.R. Veras. Univ. Central
del Caribe, PR.
A344A 960.44 Assessing the quality of dissection: a method
for improving anatomy knowledge of first year medical students.
C. Nwachukwu, N. Lachman and W. Pawlina. Mayo Med.
Sch. (318.6)
A344B 960.45 Safe Harbor Forum: professionalism reflection
sessions for first year medical students in the gross anatomy
course. C. Spampinato, C. Wittich and W. Pawlina. Mayo Clin.
Med. Sch. (447.6)
TUESDAYANATOMY
961. ANATOMY EDUCATION — EDUCATIONAL
COMMUNITY OUTREACH
Poster
Exhibit Halls A-B
A345 961.1
Our success in translating anatomy academy,
an intervention program for 5th and 6th grade students, from
Los Angeles, CA to Salt Lake City, UT. K.S. Steed, M. Diaz, K.
Ojukwu, J. Padilla, K. Jenkins, J. Lassetter and J.J. Wisco.
Col. of Nursing, Brigham Young Univ., UCLA David Geffen Sch.
of Med. and Fielding Sch. of Publ. Hlth. and Charles R. Drew
Univ.
A346 961.2
Augmenting the learning of anatomy beyond
the traditional laboratory experience through service teaching
of elementary school students: a medical student perspective.
H. Lee, K. Ojukwu, M. Diaz, J. Padilla, C. Thang and J.J.
Wisco. David Geffen Sch. of Med. at UCLA, UCLA Fielding
Sch. of Publ. Hlth. and Brigham Young Univ.
A347 961.3
Introducing anatomical concepts to junior
high school students: early engagement. T. Franz-Odendaal.
Mount Saint Vincent Univ., Canada.
A348 961.4
Learning by teaching: service learning in
anatomy. J.M. Montante, R. Nazar and M. Bee. Oakland Univ.
William Beaumont Sch. of Med. and Univ. of Detroit Mercy.
A349 961.5
MedStart: a hands-on anatomical experience
for middle school students. B.M. Laitman, A. Witkin, A. Parikh,
A. Armstrong, S. Zuckerman, R. Bhattacharya, E. Chu, M.
Schneiderman, A-G. Palermo, S.H. Factor, J.S. Reidenberg
and J.T. Laitman. Mount Sinai Sch. of Med.
A350 961.6
Emphasis placed on active learning in
remodeling the histology course in the prematriculation summer
program for entering medical and dental students. A.M. Stefan.
Med. Col. of Georgia at Georgia Regents Univ.
A351 961.7
Evaluation of student participation and
perceptions of a neuroscience community outreach project. J.
Neal and B. Puder. California Sch. of Podiat. Med. and Samuel
Merritt Univ.
A352 961.8
Medical students applying newly learned
anatomy knowledge as part of a mentoring and experiential
learning environment with undergraduate and elementary
students. C.K. Thang, M. Diaz, J. Padilla, K. Ojukwu, H. Lee,
N. Schmalz and J. Wisco. David Geffen Sch. of Med. at UCLA,
UCLA Fielding Sch. of Publ. Hlth. and Brigham Young Univ.
962. DEVELOPMENT AND GROWTH: BIRTH
DEFECTS
Poster
Exhibit Halls A-B
A353 962.1
Analysis of overlapping phenotypes from
trisomic and euploid embryos of a Down syndrome mouse
model (Ts65Dn): implications for human medicine. N. Bhatia,
R. Diogo and R. Roper. Howard Univ. and Indiana Univ.Purdue Univ. Indianapolis.
A354 962.2
Zinc supplementation prevents diabetesinduced heart malformation in mouse model. D.K. Srinivasan,
V. Murugaiyan and S.S.W. Tay. Lee Kong Chian Sch. of Med.,
Nanyang Technol. Univ., Singapore, Natl. Univ. of Singapore
and SUNY, Brooklyn.
A355 962.3
Identification of nicotinic acetylcholine receptor
subunit expression in early avian embryos. Z. Haroon, J.
Stathos, D. Higgins, J.T. Olley, P.R. Brauer and M.V. Reedy.
Creighton Univ.
A356 962.4
Developmental horizons in the 2-4 month old
infant aerodigestive tract. B.M. Micham and J.T. Laitman.
Mount Sinai Sch. of Med.
A357 962.5
Mutations disrupting PI3K signaling act as
dominant enhancers of ethanol teratogenicity. N. McCarthy,
L. Wetherill, C.B. Lovely, M.E. Swartz, T.M. Foroud and J.K.
Eberhart. Univ. of Texas at Austin and Indiana Univ. Sch. of
Med.
A358 962.6
Historical development of the surgical
technique for cleft lip and palate surgery: Bourgery’s Treatise
on Human Anatomy, 1854. M.D. Barros, J.D.B. Andreotti, S.F.
Levy, D.F. Curcio and B.M. Liquidato. Santa Casa Sch. of
Med. Sci., São Paulo.
A359 962.7
Insertion of a functional copy of six2 into the
mouse genome to examine prenatal morphogenetic factors
leading to chronic renal failure in the adult. C. Chang, Z.
Stoytcheva, J. Marh, J. Dee, B. Fogelgren, S. Lozanoff and
S. Moisyadi. John A. Burns Sch. of Med., Univ. of Hawaii.
963. DEVELOPMENT AND GROWTH: CRANIOFACIAL
Poster
Exhibit Halls A-B
A360 963.1
Early craniofacial bone growth and maturation
of Fgfr2+/P253R mice and littermates. C. Percival, T. Pankratz, Y.
Huang, X. Zhou, E.W. Jabs, R. Li and J.T. Richtsmeier. Penn
State and Mount Sinai Sch. of Med.
A361 963.2
Ephrin reverse signaling induces mouse palatal
fusion and epithelial to mesenchymal transition in cultured
medial edge epithelia. M.J. Serrano, A. Nawshad, I. Ibrahim,
J. Dyke, K.K. Svoboda and M.D. Benson. Baylor Col. of Dent.
and Col. of Dent., Univ. of Nebraska Med. Ctr.
A362 963.3
Amphibian
muscle
development
and
homologies: broader developmental and evolutionary
implications, with notes on metamorphosis and terminal
additions. J. Ziermann and R. Diogo. Howard Univ.
A363 963.4
The role of BCL11 transcription factors in
mouse craniofacial suture development. K. Kyrylkova, U.T.
Iwaniec and M. Leid. Oregon State Univ.
A364 963.5
Refining the timeline of conjunctival papillae
induction in the chick scleral ossicle system. K. Jourdeuil and
T. Franz-Odendaal. Dalhousie Univ. and Mount Saint Vincent
Univ., Halifax, Canada.
A365 963.6
Patterns of morphological integration of the
face in boys with autism spectrum disorders. K. Aldridge,
I.D. George, J.R. Austin, Y. Duan and J.H. Miles. Univ. of
Missouri-Columbia, Sch. of Med. and Thompson Ctr. for Autism
& Neurodevelop. Disorders.
A366 963.7
The influence of dentition on the developing
mandible in a mouse model. M.A. Holmes. Johns Hopkins Sch.
of Med.
325
T
U
E
ANATOMYTUESDAY
964. DEVELOPMENT AND GROWTH: LIMBS
Poster
Exhibit Halls A-B
A367 964.1
Multiscale modeling goes out on a limb: in silico
simulations of developmental mechanisms shared between
somitogenesis and the developing embryonic avian limb bud.
J.S. Gens, J. Srividhya, J.M. Belmonte, S.D. Hester and J.A.
Glazier. Indiana Univ. and Univ. of Arizona.
A368 964.2
A novel role for Tbx3 in regulating digit number
in the developing limb by Shh dependent and independent
mechanisms. U.J. Emechebe, P. Kumar, K. Thomas and A.
Moon. Univ. of Utah and Geisinger Clin., Danville, PA.
A369 964.3
Upregulation of sonic hedgehog by fibroblast
growth factor: Is TFAP2C a downstream intermediate? A.
Coggins, C.U. Pira, J.M. Feenstra and K.C. Oberg. Loma
Linda Univ.
A370 964.4
Testing hypotheses of growth in the developing
chicken limb bud. D.A. Fowler, E.B. Searle, C. Button, E.K.
Chan and H.C.E. Larsson. McGill Univ., Canada.
A371 964.5
The effects of cyclopamine on the ontogeny of
fibroblast growth factor 8 mRNA expression during embryonic
development of the chick limb. J. Maze, J. Smith and B. Roche.
Lander Univ., SC.
965. DEVELOPMENT AND GROWTH: NEURAL
CREST AND PLACODES
Poster
Exhibit Halls A-B
A376 966.1
Insights from transcriptional profiling the
mouse hindbrain: novel feedback between retinoids and Hox
genes. M. Yurieva, B. De Kumar and R. Krumlauf. Stowers
Inst. for Med. Res., Kansas City, MO.
A377 966.2
A simple PCR-based strategy for estimating
species-specific contributions in chimeras and xenografts. E.L.
Ealba and R.A. Schneider. UCSF.
A378 966.3
LMX1B-regulated nephrogenesis: a role for
proteoglycans. A.J. Espinoza, J. Feenstra, C. Pira and K.
Oberg. Sch. of Med., Loma Linda Univ.
A379 966.4
Cold-inducible RNA binding protein in breast
development and disease. R.S. Hartley, S. Garcia, L. Ruan, G.
Herrera, T.A. Mitchell, T. Howard and H.J. Hathaway. Univ. of
New Mexico Hlth. Sci. Ctr.
967. ANATOMICAL BASIS OF DEVELOPMENT
PATHOGENESIS OF DISEASE
Poster
Exhibit Halls A-B
Poster
Exhibit Halls A-B
A372 965.1
Evidence for dynamic rearrangements but lack
of fate or position. M.C. McKinney, K. Fukatsu, J. Morrison, R.
McLennan, M.E. Bronner and P.M. Kulesa. Stowers Inst. for
Med. Res., Kansas City, MO and Caltech.
A373 965.2
germ cell nuclear factor (Gcnf/Nr6a1) plays
a novel role in neural crest cell induction. A. Achilleos, J.
Dennis, S. Bhatt, D. Sakai and P. Trainor. Stowers Inst. for
Med. Res., Kansas City, MO.
A374 965.3
Using the antiphosphatase paladin to
understand the phosphoregulation of neural crest development.
J. Roffers-Agarwal, K.J. Hutt and L.S. Gammill. Univ. of
Minnesota, Minneapolis and Prince Henry’s Inst., Clayton,
Australia.
A375 965.4
Expression and function of tenascin-C during
colorectal enteric nervous system development. N. Nagy,
S. Akbareian, C. Steiger, D. Molnar, C. Barad and A.M.
Goldstein. Semmelweis Univ. Fac. of Med., Hungary and
Massachusetts Gen. Hosp., Harvard Med. Sch.
LAST DAY TO VISIT
EXHIBITS
Tuesday, April 23
9:00 AM – 4:00 PM
326
966. DEVELOPMENT AND GROWTH: GENE AND
PROTEIN EXPRESSION
A380 967.1
The chick embryo neural crest model system
reveals a unique role for EphB6 in melanoma metastasis. C.M.
Bailey and P.M. Kulesa. Stowers Inst. for Med. Res., Kansas
City, MO.
A381 967.2
Empirical development of a histological protocol
for whole brain sectioning to characterize neuropathological
patterns in human specimens. K.M. Chan, N.A. Schmalz, K.
Choy, A. Nguyen, T.N. Pham, E. Stark, H. Dong, A.W. Toga,
H.V. Vinters and J.J. Wisco. David Geffen Sch. of Med. at
UCLA and Brigham Young Univ.
A382 967.3
Quantitative co-localization of hyaluronic acid
and damaged myelin in the aging rhesus monkey brain. L.I.
Estrada, P. Boule-Getsinger, E. Witkowski, F. Mortazavi and
D.L. Rosene. Boston Univ. Sch. of Med.
A383 967.4
Understanding craniofacial variability caused
by loss of Gata3 function. J.K. Eberhart and M.E. Swartz.
Univ. of Texas at Austin.
A384 967.5
Characterization of the avian Talpid2 mutant.
S.A. Brugmann, C-F. Chang, E.N. Schock, J. Snyder and
M.E. Delany. Cincinnati Children’s Hosp. Med. Ctr. and Univ. of
California, Davis.
A385 967.6
Three-dimensional reconstructions of human
embryos: morphogenesis and hepatic vascularization. M.
Lhuaire, E. Scharbarg, É. Micard, R. Cendre, V. Delmas, F.
Duparc, P. Mercier, J. Felblinger, M. Braun, C. Avisse and
M. Labrousse. Univ. of Reims Champagne-Ardenne, CHU de
Nancy Brabois, René Descartes Univ. Paris V, Rouen Univ.,
Angers Univ. and Henri Poincaré-Lorraine Univ., Nancy.
A386 967.7
C-jun N-terminal kinase maintains tissue
integrity during cell rearrangement in the gut. N. NasconeYoder and M. Dush. Col. of Vet. Med., North Carolina State
Univ.
TUESDAYANATOMY/BIOCHEMISTRY
A387 967.8
Syntaxin 16 is required for epithelial
morphogenesis and single lumen formation. J-J. Jung, S.M.
Inamdar, A. Tiwari, D. Ye, F. Lin and A. Choudhury. Univ. of
Iowa.
A388 967.9
microRNA-26b represses colon cancer
cell proliferation by inhibiting lymphoid enhancer factor 1
expression. Z. Sun, Z. Zhang, X. Li and B. Amendt. Univ. of
Iowa.
A389 967.10 Reducing parathyroid hormone is essential for
correcting cortical bone deficiencies associated with chronic
kidney disease. C. Newman, S.M. Moe, N.X. Chen, D.M.
Brown, V.H. Gattone and M.R. Allen. Indiana Univ. Sch. of
Med.
Biochemistry and Molecular Biology
968. MECHANISMS OF GENOMIC STABILITY
Poster
Exhibit Halls A-B
C11 969.6
Role of salicylic acid in chromatin modification
and remodeling. D. Kumar, M.I. Haq, T.A. Hotz, M.A. Hossain,
B. Zhao and D. Donald. East Tennessee State Univ.
C12 969.7
Transcription factor Sp1 promotes chromatin
remodeling at DNA double-strand breaks. K. Beishline, S.
Koduri and J. Clifford. Drexel Univ. Col. of Med.
C1
968.1
Role of Ku in the DNA damage response
activated from telomeres. V. Fell and C. Schild-Poulter. Univ.
of Western Ontario and Robarts Res. Inst., London, Canada.
C2
968.2
Activity and frequency of the ITPA P32T variant
among colorectal patients. C. Brown. Wayne State Col.
C3
968.3
Chromosome fragile sites signature and
genome instability in human epithelial cells. S.A. Hosseini, J.C.
Saldivar, S. Horton, J. Sun, N.A. Heerema and K. Huebner.
The Ohio State Univ. Wexner Med. Ctr.
C4
968.4
Coordinated
degradation
of
replisome
components ensures genome stability upon replication stress.
E. Noguchi, L. Roseaurlin and T. Toda. Drexel Univ. Col. of
Med. and Cancer Res. UK, London.
C5
968.5
Effect of high copy retrotransposon insertions
on yeast genome stability. C. Lanzillotta and L.Z. Scheifele.
Loyola Univ. Maryland.
969. CHROMATIN MODIFICATIONS AND
REMODELING IN DNA REPLICATION,
RECOMBINATION AND REPAIR
Poster
Exhibit Halls A-B
C6
969.1
Chromatin dynamics and the Fanconi anemia
DNA damage response pathway. K.L. Neira, M. Mauro and
N.G. Howlett. Univ. of Rhode Island.
C7
969.2
DNA damage repaired by the base excision
repair pathway is epigenetic. P.R. Strauss, K. Toomire and
S.P.G. Moore. Northeastern Univ.
C8
969.3
Dynamics of yeast histone H2A and H2B
phosphorylation in response to a double-strand break. C-S.
Lee, K. Lee, J.E. Haber and G. Legube. Brandeis Univ.,
CNRS, Toulouse and Univ. of Toulouse.
C9
969.4
Nucleosome
dynamics
regulate
DNA
processing. N. Adkins, H. Niu, P. Sung and C. Peterson. Univ.
of Massachusetts Med. Sch. and Yale Univ. Sch. of Med.
C10 969.5
ATP-dependent heterochromatin remodeling.
B.J. Manning and C. Peterson. Grad. Sch. of Biomed. Sci.,
Univ. of Massachusetts Med. Sch.
970. CHROMOSOME REARRANGEMENTS
Poster
Exhibit Halls A-B
C13 970.1
Analyzing the effects of sub-optimal doses
of raltegravir on HIV-1 integration. J. Varadarajan, M.J.
McWilliams, D. Hazuda and S. Hughes. NCI, NIH, Frederick
and Merck Res. Labs., West Point, PA.
971. GENOME DIVERSITY AND DNA
RECOMBINATION
Poster
Exhibit Halls A-B
C14 971.1
Large-scale structural variations linked to the
NOTCH4 locus of the human major histocompatibility complex.
J.D. Bowman, B. Zhou, C-y. Yu and S.K. Lawrance. Otterbein
Univ., OH and Nationwide Children’s Hosp.
C15 971.2
Determination of the extent of hybridization
between the threatened Hibiscus dasycalyx, Hibiscus laevis,
and Hibiscus moscheutos using ISSR genetic markers. L.M.
Baker and B. Clack. Stephen F. Austin State univ.
972. MECHANISM OF DNA RECOMBINATION
Poster
Exhibit Halls A-B
C16 972.1
Isolation and characterization of isopentenyldiphosphate isomerase from marine bacterium, Kocuria
gwangalliensis. T.H. Jeong, K. Ji, N.Y. Jang, Y.S. Cho and Y.T.
Kim. Pukyong Natl. Univ., South Korea.
327
T
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BIOCHEMISTRYTUESDAY
973. MECHANISM OF DNA RECOMBINATION
Poster
Exhibit Halls A-B
C17 973.1
Pch2 is a meiotic hexameric ATPase that binds
to and alters Hop1 functions. C. Chen, A. Jomaa, J. Ortega
and E. Alani. Cornell Univ. and McMaster Univ., Canada.
C18 973.2
Molecular delineation of BubR1 kinase function
in kinetochore microtubule attachments. H. Jiang, Y. Huang, X.
Ding and X. Yao. Anhui Key Lab. of Chem. Biol., Heifei, China,
Beijing Univ. of Chinese Med. and Morehouse Sch. of Med.
974.MUTAGENESIS
Poster
976. TRANSLESION AND ERROR-PRONE DNA
POLYMERASES
Exhibit Halls A-B
Poster
Exhibit Halls A-B
C19 974.1
ENU-induced mutagenesis in grass carp
(Ctenopharyngodon idellus) by treating mature sperm. S-M.
Zou and X-Y. Jiang. Shanghai Ocean Univ.
C20 974.2
Evaluation of oxidative DNA damage, lipid
peroxidation and antioxidant status in patients undergoing
surgery with sevoflurane anesthesia. M.G. Braz, J.E.B. Orosz,
D.T. Pierine, L.G. Braz, A.L.A. Ferreira, D.M.F. Salvadori,
K-J. Yeum and J.R.C. Braz. São Paulo State Univ., Botucatu
and USDA at Tufts Univ.
C21 974.3
Improvement of P. chrysogenum by UV
mutation for overproduction of cellulase and ligninase. O.M.
Babalola, , M.O. Abiola, E.O. Albert, I.O. Ngozi and E.N.
Miriam. Univ. of Lagos, Nigeria.
C22 974.4
Monitoring the expression and activity of the
DinB protein in vivo in Escherichia coli. B.H. Diamond and V.
Godoy-Carter. Northeastern Univ.
975. NUCLEIC ACID- SMALL MOLECULE
INTERACTIONS
Poster
Exhibit Halls A-B
C23 975.1
Structural characterization of the major DNADNA cross-link formed by epichlorohydrin. K. Sirka and J.T.
Millard. Colby Col., ME.
C24 975.2
Mechanisms of cytotoxicity of bifunctional
epoxide cross-linking agents. A. Spierer and J.T. Millard.
Colby Col., ME.
C25 975.3
Amplification of human DNA for probing DEBinduced damage via a quantitative polymerase chain reaction.
E. Chuang and J.T. Millard. Colby Col., ME.
C26 975.4
The role of microRNA-208a in cardiac
hypertrophy induced by aerobic physical training. U.P.R. Soci,
T. Fernandes, K.T. Rosa, M.C. Irigoyen, M.I. Phillips and
E.M. de Oliveira. Sch. of Phys. Educ. and Sports and INCORFMUSP, São Paulo and Keck Grad. Inst., Claremont, CA.
328
C27 975.5
A novel series of antitumor ruthenium betadiketonato compounds. J. Matthews, F. Caruso, C. Pettinari,
F. Marchetti, R. Pettinari, M. Cariboldi and M. Rossi. Vassar
Col. and Univ. of Camerino and Univ. of Insubria, Italy.
C28 975.6
Investigation of riboflavin binding to DNA using
polymerase chain reaction. M. Banco and M.A. Benore. Univ.
of Michigan at Dearborn.
C29 975.7
A novel CUGexp·MBNL1 inhibitor with
therapeutic potential for myotonic dystrophy type 1. A.H.
Jahromi and S.C. Zimmerman. Univ. of Illinois, Urbana.
C30 975.8
DNA-nuclear protein interactions around -224
A/G single nucleotide polymorphism in the neuropeptide
receptor Y2 (NPY2R) gene in predisposition to hypertension.
E.M. Albino-Rodriguez, T. Katsuya, A. Deng and J. Dutil.
Ponce Sch. of Med., PR, Osaka Univ. Grad. Sch. of Med. and
Univ. of Montreal Res. Ctr. CHUM.
C31 976.1
Functional studies of point mutation G295R on
the catalytic core of human DNA polymerase h. A.J. Valdez, M.
Kumar and X. Jiang. Tennessee Technol. Univ.
C32 976.2
Site-directed
mutagenesis,
expression,
purification and translesion synthesis analysis of human DNA
polymerase h mutations found in xeroderma pigmentosum
variant and melanoma patients. M. Kumar and X. Jiang.
Tennessee Technol. Univ.
C33 976.3
Werner’s syndrome protein limits the errorprone 8-oxo-G lesion bypass activity of human DNA polymerase
kappa by promoting the error-free bypass. L. Maddukuri, S.D.
Eddy and R.L. Eoff. Univ. of Arkansas for Med. Sci.
C34 976.4
Regulation of DNA damage tolerance by the
AhR pathway and its role in glioma progression. A. Bostian
and R. Eoff. Univ. of Arkansas for Med. Sci.
C35 976.5
Overexpression of human polymerase n in E.
coli. S.C. Shissler and X. Jiang. Tennessee Technol. Univ.,
Oak Ridge and Cookeville.
C36 976.6
Replication of G-quadruplexes by archaeal
DNA polymerases. S.D. Eddy, L. Maddukuri and R.L. Eoff.
Univ. of Arkansas for Med. Sci.
C37 976.7
Antibiotic resistance acquired through a DNA
damage-inducible response in Acinetobacter baumannii. M.D.
Norton and V.G. Godoy. Northeastern Univ.
977.TRANSPOSITION
Poster
Exhibit Halls A-B
C38 977.1
Cooperative role of MMP-3 and HP1 in heat
shock protein transcription. T. Eguchi and S. Calderwood.
Beth Israel Deaconess Med. Ctr., Harvard Med. Sch.
TUESDAYBIOCHEMISTRY
978.CHROMOSOMES
Poster
Exhibit Halls A-B
C39 978.1
HU decreases diffusible supercoiling density
in bacterial chromosome. A.A. Agbleke, N. Rovinskiy,
O. Chesnokova and P.N. Higgins. Univ. of Alabama at
Birmingham.
C40 978.2
Cohesin-dependent association of tRNA
genes with nuclear pore complexes in budding yeast. M. Chen
and M.R. Gartenberg. UMDNJ-Robert Wood Johnson Med.
Sch.
979. MITOTIC SPINDLE
Poster
Exhibit Halls A-B
C41 979.1
Aurora-A-elicited
astrin
phosphorylation
regulates mitotic progression. S-C. Chiu, J-M.M. Chen, M-C.
Liu and C-T.R. Yu. China Med. Univ., China Med. Univ. Hosp.
and Natl. Chi Nan Univ., Taiwan.
980. MECHANISMS OF GENE TRANSCRIPTION AND
REGULATION II
Poster
Exhibit Halls A-B
Session I scheduled on Monday.
C42 980.1
Function of CDK8 submodule and TRIM28
in transcriptional regulation at HSPA1B. H. Bunch and S.
Calderwood. Beth Israel Deaconess Med. Ctr., Harvard Med.
Sch.
C43 980.2
The QA repeat domain of TCERG1 plays a role
in inhibiting C/EBPa and in its ability to undergo redistribution
in the nucleus. W.J. Roesler, N. Miller, N. Timchenko and B.
Moazed. Univ. of Saskatchewan and Baylor Col. of Med.
C44 980.3
Transcriptional
regulator
MftR
from
Burkholderia thailandensis participates in oxidative stress
responses. A. Gupta and A. Grove. LSU.
C45 980.4
Regulation of CFTR gene expression by
recruitment of an intestinal transcription factor network. J.
Kerschner and A. Harris. Children’s Hosp. of Chicago Res.
Ctr. and Northwestern Univ. Feinberg Sch. of Med.
C46 980.5
Identify PCBP1-interacting protein and its
novel functional role on human MOR gene expression. P.
Nahar-Gohad, H. Sultan, Y. Esteban, A. Stabile and J. Ko.
Seton Hall Univ.
C47 980.6
Effects of recognition sequence variations on
transcription regulation of multidrug resistance regulator Pdr1p
in yeast. N. Nishida, K. Kuroda and M. Ueda. Kyoto Univ.
Grad. Sch. of Agr.
C48 980.7
Characterization of lysine-specific demethylase
1 as a potential olfactory receptor regulator. A.L. Savarino, S.
Kilinc and R. Lane. Wesleyan Univ.
C49 980.8
Extra-transcriptional effects of RNA polymerase
III transcription complex on neighboring RNA polymerase II
transcribing genes in Saccharomyces cerevisiae. A. Korde,
J.M. Rosselot and D. Donze. LSU.
C50 980.9
The Ure2 acap is required for GATA factor
responses to rapamycin, but not nitrogen limitation. J.J. Tate,
A. Feller, I. Georis, E. Dubois and T.G. Cooper. Univ. of
Tennessee Hlth. Sci. Ctr., Memphis and Univ. Libre of Brussels.
C51 980.10 Study on the neurogenic mechanisms of
traumatic brain injury. H. Duan, Y. Fan, C. Hao, S. Li, S. Wang,
H. Wang, D. Kuai, S. Lian and N. Xue. First Clin. Col. of Shanxi
Med. Univ., China.
981. EPIGENETICS: HISTONE AND DNA
MODIFICATIONS
Poster
Exhibit Halls A-B
C52 981.1
The role of neuropeptide Y and aquaporin 4 in
the pathogenesis of intestinal dysfunction caused by traumatic
brain injury. H. Duan, C. Hao, S. Li, Y. Fan, H. Wang, J. Hao, Y.
Liu and X. Liu. The First Clin. Col. of Shanxi Med. Univ., China.
C53 981.2
MeCP2_e2 does not contribute Rett syndrome
phenotypes but essential for placenta. M. Itoh, C.G.T. Tahimic,
Y-i. Goto and A. Kurimasa. Natl. Ctr. of Neurol. and Psychiat.,
Kodaira and Tottori Univ., Japan.
C54 981.3
Epigenetic
markers
in
patients
with
endometriosis. K.L. Ray, M. Isme, C. Cook, M. Massie, B.
Dawley and N. Santanam. Marshall Univ. and Bluefield State
Col., WV.
C55 981.4
Epigenetic changes in human cells exposed
to X-rays. M.A. Chaudhry and R.A. Omaruddin. Univ. of
Vermont.
C56 981.5
IGF1 growth hormone response element
undergoes
developmentally
regulated
demethylation
independent of STA5b. R.A. McKnight, J. Wiedmeier, X. Yu,
C.W. Callaway and R.H. Lane. Univ. of Utah.
C57 981.6
High fat diet induced genome-wide differential
methylation affecting hepatic signaling pathways in rat. Y.
Zhang, D. Zhou, J. Ma, Y-X. Pan and H. Chen. Univ. of Illinois
at Urbana-Champaign.
C58 981.7
The detection of 5-hydroxymethylcytosine in
Trypanosoma brucei DNA. E. Valentine, R. Smindak and K.T.
Militello. SUNY at Geneseo.
C59 981.8
Replication and transcription of SV40 direct
distinct epigenetic signaling. B. Milavetz, L. Kallestad, A.
Gefroh, E. Woods and K. Christensen. Univ. of North Dakota.
C60 981.9
Regulation of the DNA-binding protein CFP1
by ERK1/2. A.M. Klein, S. Earnest and M.H. Cobb. Univ. of
Texas Southwestern Med. Ctr.
329
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BIOCHEMISTRYTUESDAY
982.HETEROCHROMATIN
985. FRONTIERS IN RNA BIOLOGY
Poster
Poster
Exhibit Halls A-B
Exhibit Halls A-B
C61 982.1
Sirtuins mediate cohesion of silenced domains
in Saccharomyces cerevisiae. Y-F. Chen and M. Gartenberg.
UMDNJ-Robert Wood Johnson Sch. of Med.
983. NON-CODING RNAS IN GENE REGULATION
AND CHROMOSOME STRUCTURE
Poster
Exhibit Halls A-B
C62 983.1
Identification of SCAL1, a novel long noncoding RNA, induced by cigarette smoke and associated with
lung cancer. P. Thai, S. Statt, E. Liang, C. Campbell and R.
Wu. Univ. of California, Davis.
984. RECOMBINANT DNA TECHNOLOGY
Poster
Exhibit Halls A-B
C63 984.1
A biologist’s resource for protein expression
plasmids: the Protein Structure Initiative:Biology-Materials
Repository. C. Cormier, J. Park, M. Fiacco, J. Steel, P. Hunter
and J. LaBaer. Biodesign Inst., Arizona State Univ.
C64 984.2
Vaccination of BALB/c mice against a murine
hookworm model. M.W. Schlotterback, P. Comella, C. Horien,
K. Neutzling, K. Luk, E. Richards and J. Pearson. Concordia
Col., MN.
C65 984.3
Innovative immunological assays for diagnosis
of Schistosoma mansoni for clinical acute and/or chronic forms.
R.F.G. Queiroz, D. Harn and P.M. Coelho. Fiocruz, Belo
Horizonte, Brazil and Univ. of Georgia.
C66 984.4
Large-scale expression and purification of
active pseudolysin in Escherichia coli. R.S. Tarpley, O.A.
Adekoya, I. Sylte and O.O. Odunuga. Stephen F. Austin State
Univ., TX and Univ. of Tromsø, Norway.
C67 984.5
Novel method for the scarless single-step
assembly of many small DNA sequences. T.L. Roth, L.
Milenkovic and M. Scott. Stanford Univ.
C68 984.6
Synthetic biology and the production from
Brazilian spider silk protein Masp1 in E. coli system. V.A.
Michalczechen-Lacerda, P.F. Oliveira, G.R. Vianna, A.M.
Murad, D.L. Kaplan and E. Rech. Tufts Univ. and Univ. of
Brasilia.
C69 985.1
Inhibition of HIV-1 transcription by a tunable
chimeric tRNA(Ser)-nucloelar localizing trans-activation
response element decoy. C. Stevens, L. Scherer, J. Rossi and
K. Haushalter. Harvey Mudd Col., CAand Beckman Res. Inst.,
Duarte, CA.
986. RIBOSOME AND TRANSLATION
Poster
Exhibit Halls A-B
C70 986.1
The disassembly of post-termination complex
by ribosome recycling factor and EF-G occurs first with the
releases of tRNA, mRNA, and splitting of the ribosome in its
order – IF3 does not participate in this reaction. A. Kaji, N.
Iwakura and H. Kaji. Univ. of Pennsylvania Sch. of Med. and
Thomas Jefferson Univ. Kimmel Cancer Ctr.
C71 986.2
Actin bundling mutants in translation elongation
factor 1A induce altered protein synthesis at both the initiation
and elongation steps. W.B. Perez and T.G. Kinzy. UMDNJRobert Wood Johnson Med. Sch.
C72 986.3
Cloning and characterization of leucyl-tRNA
synthetase from Pseudomonas aeruginosa. E. Medellin, H.
Salazar, N. Quach, P. Chavero and J. Bullard. Univ. of Texas
-Pan American.
C73 986.4
Enzymatic analysis of EF-Tu and EF-Ts from
Pseudomonas aeruginosa. A. Tran, S. Palmer and J. Bullard.
Univ. of Texas-PA.
C74 986.5
Cloning and characterization of EF-Tu and EFTs from Bacillus subtilis. C. Rivera, V. Garcia and J. Bullard.
Univ. of Texas-PA.
C75 986.6
Evolution of ribosomal RNA: universal and
domain-specific conserved sequences. S.A. Gerbi, S.M. Doris,
D. Smith, B. Raphael, J. Beamesderfer and J. Nathanson.
Brown Univ.
C76 986.7
Widespread regulation of translation by
elongation pausing in heat shock. R. Shalgi, S. Lindquist and
C.B. Burge. MIT and Whitehead Inst. for Biomed. Res.
C77 986.8
Primary and alternative S18 ribosomal protein
in Mycobacterium tuberculosis. S. Prisic and R.N. Husson.
Boston Children’s Hosp./Harvard Med. Sch.
987. RNA EDITING AND MODIFICATION
Poster
Exhibit Halls A-B
C78 987.1
Characterization of putative mitochondrial
processing peptidase a-subunit in Trypanosoma brucei. I.L.
Mak, Z. Lu, V.N. Mehta and R. Salavati. McGill Univ.
330
TUESDAYBIOCHEMISTRY
988. RNA PROCESSING
991. RNA TRANSPORT AND LOCALIZATION
Poster
Poster
Exhibit Halls A-B
Exhibit Halls A-B
C79 988.1
Structural insights into RNase T in RNA
maturation and DNA repair. H.S. Yuan, Y-Y. Hsiao and W-C.
Chu. Inst. of Molec. Biol., Acad. Sinica, Taipei and Natl. YangMing Univ., Taiwan.
C80 988.2
Investigation of functionally critical residues
in the pseudo-helicase domain of Brr2. D. Anguiano, C.M.
Brittsan, J.K. Titus, W. Boswell, C. Guthrie and C. Maeder.
Texas State Univ.-San Marcos and UCSF.
C81 988.3
Comprehensive mechanistic analysis of the
RNA-lariat debranching enzyme. E.M. Ransey, S. Dey, S. Das
and M. Macbeth. Carnegie Mellon Univ.
C82 988.4
Alternative substrate kinetics of Escherichia
coli ribonuclease P: determination of relative rate constants
by internal competition. L.E. Yandek, H-C. Lin and M. Harris.
Case Western Reserve Univ.
C83 988.5
Insights into splicing: structure of the yeast
U1 snRNP. C. van der Feltz, N. Grigorieff and D. Pomeranz
Krummel. Brandeis Univ. and HHMI, Chevy Chase, MD.
989. RNA STRUCTURE AND DYNAMICS
Poster
Exhibit Halls A-B
C84 989.1
Molecular dynamics study of the stability of the
sarcin/ricin domain of RNA. M.F. Bruist and C. Cavanaugh.
Univ. of Sciences in Philadelphia.
C85 989.2
Conformational stability of loop E in the potato
spindle tuber viroid. R.M. Salvo, M.F. Bruist and T. Baumstark.
Univ. of Sciences, Philadelphia and Cornell Univ.
990. RNA STRUCTURE, FUNCTION AND
REGULATION
Poster
Exhibit Halls A-B
C86 990.1
The amyotrophic lateral sclerosis and
frontotemporal dementia-associated C9ORF72 r(GGGGCC)n
hexanucleotide repeat forms extremely stable uni- and multimolecular RNA G-quadruplex structures. K. Reddy, B. Zamiri,
S. Stanley, R. Macgregor and C. Pearson. The Hosp. for Sick
Children and Univ. of Toronto.
C87 991.1
Regulation of mRNA export by the PI3 kinase/
AKT signaling pathway. E.A. Vancor, A.J.C. Quaresma and
J.A. Nickerson. Univ. of Massachusetts Med. Sch.
992. RNA TURNOVER
Poster
Exhibit Halls A-B
C88 992.1
A stress-activated, p38 MAPK-ATF/CREB
pathway regulates the post-transcriptional decay of target
mRNSs. J. Gao, J.L. Wagnon, R.M. Protacio, G.V. Glazko,
M. Beggs, V. Raj, M.K. Davidson and W.P. Wahls. Univ. of
Arkansas for Med. Sci.
993. REGULATORY THIOL MODIFICATIONS
Poster
Exhibit Halls A-B
C89 993.1
Turnabout is fair play: mutual regulation of
palmitoylation and raft partitioning. I. Levental and K. Simons.
Univ. of Texas Hlth. Sci. Ctr. at Houston and Max Planck Inst. of
Cell Biol. and Genet., Dresden.
C90 993.2
A redox insensitive triple cysteine mutant of
SirT1 rescues oxidative stress-induced apoptosis. D. Shao,
J. Fry, R. Zee, V. Kumar, D. Pimentel, R. Cohen and M.
Bachschmid. Boston Univ.
C91 993.3
Modulation of signaling proteins by reversible
cysteine modification. J.D. Keyes, K. Nelson, D. Parsonage,
L. Daniel, C. Furdui and L. Poole. Wake Forest Univ.
C92 993.4
Oxidation of the Hsp70 BiP protects cells
during ER stress. C. Sevier, K. Pareja and J. Wang. Cornell
Univ.
994.AUTOPHAGY
Poster
Exhibit Halls A-B
C93 994.1
Role of HSF1 and FoxO3 in proteotoxic stress
induced macroautophagy. A. Murshid, S.D. Chou, T. Eguchi
and S. Calderwood. Beth Israel Deaconess Med. Ctr., Harvard
Med. Sch.
C94 994.2
Failure of autophagy induction makes multidrug
resistant cells vulnerable to BH3-mimetic gossypol. J-H. Ahn,
G-H. Jang and M. Lee. Univ. of Incheon, South Korea.
331
T
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BIOCHEMISTRYTUESDAY
C95 994.3
Mitophagy as a quality control mechanism in
Saccharomyces cerevisiae. H. Abeliovich, M. Zarei, K.T.G.
Rigbolt, R.J. Youle and J. Dengjel. Hebrew Univ. of Jerusalem,
Freiburg Inst. for Adv. Studies, Germany and NINDS, NIH.
C96 994.4
The role of enhanced autophagy in acquired
resistance to new B-Raf inhibitor UI-152. G-H. Jang, J-H. Ahn
and M. Lee. Univ. of Incheon, South Korea.
C97 994.5
Effects of aging on the heat shock response
and autophagy in human peripheral blood mononuclear
cells. K.R. Lanphere, S. Schneider, C. Mermier, M. Zuhl, K.
Dokladny and P. Moseley. Univ. of New Mexico.
C98 994.6
B19, a novel monocarbonyl analogue of
curcumin induced human ovarian cancer cells apoptosis
via activation endoplasmic reticulum stress and autophagy
signaling pathway. J. Xiao, W. Qu, Z. Wang, H. Shi and H.
Zhang. Wenzhou Med. Col., China.
C99 994.7
The effect of HSF-1 and HSP70 on autophagy
regulation. K. Dokladny, V. Deretic and P.L. Moseley. Univ. of
New Mexico.
C100 994.8
Effect of a six week exercise training program
on proteolytic enzyme activity, ROS generation and autophagy
in the white gastrocnemius and left ventricle of normotensive
and hypertensive rats. E.M. McMillan, M-F. Paré and J.
Quadrilatero. Univ. of Waterloo, Canada.
C101 994.9
A protocol for screening of autophagy
regulatory genes applying cell sorting and next-generation
sequencing technologies. W-P. Huang and A-Y. Liu. Natl.
Taiwan Univ.
995. PROTEASES IN CELL REGULATION AND
DISEASE
Poster
Exhibit Halls A-B
C102 995.1
Expression of recombinant human neutrophil
cathepsin G in Pichia pastoris. E.T. Perry, E. Smith and D.
Johnson. East Tennessee State Univ. Quillen Col. of Med.
C103 995.2
Extracellular thimet oligopeptidase is carried
by cell membrane microvesicles of prostate cancer cells. Y. Liu,
L.A. Bruce and A.J. Wolfson. Wellesley Col.
C104 995.3
Perillyl alcohol and rapamycin-mediated
inhibition of migration and invasion. T. Sundin, P. Mollica, D.
Peffley and P. Hentosh. Old Dominion Univ.
C105 995.4
Nuclear MMP-2: presence and activity in
cardiac myocytes. M.Y. Kondo, M.M. Castro, F. Fan and R.
Schulz. Univ. of Alberta.
C106 995.5
Caspase-1 activation is critical for endothelial
activation and early atherogenesis. Y. Yin, H. Wang and X-f.
Yang. Temple Univ. Sch. of Med.
C107 995.6
The activation of factor VII by a variety of
potential activators. K. Ke and J. Morrissey. Univ. of Illinois,
Urbana.
C108 995.7
Development of affinity purification systems for
isolation and proteomic analysis of proteases from Tetrahymena
thermophila. B. Lu, J.R. Carreon and J.W. Straus. Vassar
Col., NY and Ramapo Col., NJ.
C109 995.8
RpoS is directly controlled by ATP levels. C.
Peterson. Suffolk Univ., MA.
332
996. PROTEIN FOLDING, MISFOLDING AND
AGGREGATION
Poster
Exhibit Halls A-B
C110 996.1
Dual role of the metalloprotease FtsH in
biogenesis of the DrrAB drug transporter. W. Li. Georgia State
Univ.
C111 996.2
Detection of pathological tau conformers in
cerebrospinal fluid. Z.M. March, S. Gupta and D.W. Colby.
Univ. of Delaware and Indian Inst. of Technol.-Gandhinagar.
C112 996.3
Antiparallel b structure in Ab42 oligomers. L.
Gu, C. Liu and Z. Guo. UCLA.
C113 996.4
Probing
molecular
mechanism
of
destabilization and misfolding of human apolipoprotein A-I
in familial amyloidosis. M. Das, X. Mei, D. Atkinson and O.
Gursky. Boston Univ. Sch. of Med.
C114 996.5
Structural and functional importance of thirdcircuit hydrogen bonds within hemolysin A. M.A. Apolinario
and T.M. Weaver. Univ. of Wisconsin-La Crosse.
C115 996.6
Hydrazines as potential anti-amyloidogenic
agents. S. Ghosh , C. Schifone, M. Foster, B. Torok, H. Levine
III and M. Torok. Univ. of Massachusetts Boston and Univ. of
Kentucky.
C116 996.7
Synthesis
of
functional
proteins
via
bioconjugation. M. Pirigyi and N.J. Zondlo. Univ. of Delaware.
C117 996.8
Isoflurane preconditioning involves the
upregulation of aquaporin genes. Z. Schwamb, N. Seidler and
C. Theisen. Kansas City Univ. of Med. and Biosci.
C118 996.9
The circulating molecular chaperone clusterin
interacts with amyloidogenic transthyretin oligomers and
modulates amyloid formation. M.J. Greene, E. Klimtchuk, C.
Koch, D. Seldin and L.H. Connors. Boston Univ. Sch. of Med.
C119 996.10 A single-molecule fluorescence system for
studying adenylate kinase under force. C.A.M. Wilson, S.M.
Leachman, B. Cervantes, A. Ierokomos, S. Marqusee and
C. Bustamante. Univ. of California, Berkeley.
C120 996.11 Structural
and
kinetic
differences
in
oligomerization-fibrillation of serum amyloid A and not the
intrinsic amyloidogenicity may contribute to pathogenesis in AA
amyloidosis. S. Srinivasan, S. Patke, J.J. Aguilera, R.S. Kane
and W. Colon. Rensselaer Polytech Inst.
C121 996.12 Beta-arc 2 hydrogen bond network within
hemolysin A facilitates hemolytic activation. E. Glasgow and T.
Weaver. Univ. of Wisconsin-La Crosse.
C122 996.13 Contribution of an inner core hydrogen-bonding
network to b-helix stability within the two-partner secretion
exotoxin family. T.M. Weaver. Univ. Wisconsin-La Crosse.
C123 996.14 Production and characterization of oxidationresistant variants of the human ribonuclease inhibitor. A.W.
Uebersohn and K.A. Dickson. Lawrence Univ., WI.
C124 996.15 Analysis of the yeast de novo protein
YNR034W-A. A. Shi and M. Cordes. Univ. of Arizona.
C125 996.16 Mortal Kombat: modeling amyloid fibrils and
health implications. M. Smaoui, F. Poitevin, M. Delarue, P.
Koehl, H. Orland and J. Waldispuhl. Sch. of Computer Sci.,
McGill Univ., Inst. Pasteur, Univ. of California, Davis and CEASaclay, Gif-sur-Yvette, France.
TUESDAYBIOCHEMISTRY
C126 996.17 ER stress-independent noncanonical UPR
activation under phenformin treatment. L. Yang, H. Sha, Z. Xue
and L. Qi. Cornell Univ.
997. MASS SPECTROSCOPY
Poster
C138 998.8
Ligand binding and conformational change
coupling in the HAD superfamily. D. Saltzberg, V. Ovchinnikov,
D. Dunaway-Mariano, M. Karplus and K. Allen. Boston Univ.,
Harvard Univ. and Univ. of New Mexico.
999. MOLECULAR MOTORS - FORCE AND WORK AS
PRODUCTS
Exhibit Halls A-B
Poster
Exhibit Halls A-B
C127 997.1
A systematic study of the chemical stress
response induced by bleach and vinegar in E. coli on viability
and protein expression profiles using plating assays and
matrix-assisted laser desorption ionization Biotyper™ system.
S. Liu and D. Vardar-Ulu. Wellesley Col.
C128 997.2
Mass spectrometric immunoassay for insulinlike growth factor 1. D. Nedelkov, E. Niederkofler, D. Phillips,
B. Krastins, U. Kiernan, K. Tubbs and M. Lopez. Thermo
Fisher Scientific, Tempe, AZ and Cambridge, MA.
C129 997.3
Muscle fiber typing by identification of the
myosin heavy chain using LCMS. J. Kasper, D. Johnson, E.
Hayes and D. King. Taylor Univ., IN.
C130 997.4
Development of LCMS method for monitoring
the effects of meat feasting, fasting, and exercise on urinary
3MH levels. S. Fenstermacher, K. Cleary, E. Hayes and D.
King. Taylor Univ. , IN.
998. CATALYTIC MECHANISMS
C139 999.1
Plasticity of the kinesin-microtubule interaction
is encoded by the motor domain beta-sheet. J. Richard, E.
Kim, E. Wojcik and S. Kim. LSU Hlth. Sci. Ctr., New Orleans.
C140 999.2
ATPase coupling in the processive RNA
helicase NS3 from hepatitis C virus. M.J. Bradley, A. Henn, S.
Ding, A. Pyle and E. De La Cruz. Yale Univ., Technion Israel
Inst. of Technol., Sanford-Burnham Med. Res. Inst., La Jolla
and HHMI, New Haven.
C141 999.3
Unraveling the architecture of the A1 complex
of the Nanoarchaeum equitans A1A0 ATP synthase. S.
Mohanty and C.W.V. Hogue. Natl. Univ. of Singapore.
C142 999.4
A search for novel substrate activity in mutants
of L-alanine dehydrogenase. H. Aldeborgh and E. Mundorff.
Vassar Col. and Hofstra Univ.
C143 999.5
Electron transfer without metal:. how amino
acid radicals (mis)behave. W.H. Koppenol, L. Mahmoudi, R.
Kissner and T. Nauser. ETH, Zurich.
Poster
Exhibit Halls A-B
C131 998.1
Design and characterization of Thermotoga
maritima glycerol dehydrogenase to reduce inactivation by
dihydroxyacetone. P.G. Gross, J. Beauchamp and C. Vieille.
Michigan State Univ.
C132 998.2
The structure, regulation and activity of noncanonical inteins. K.V. Mills, J.N. Reitter, K.R. Connor, M.C.
Nicastri, J.E. Williams, K.M. Colelli and M.D. Marieni. Col. of
the Holy Cross.
C133 998.3
Rational enzyme redesign for enhancing activity
and selectivity of heterologous taxane oxidation in engineered
E. coli. V.G. Yadav, S.M. Edgar and G. Stephanopoulos. MIT.
C134 998.4
Towards the nitric oxide reductase mechanism
of flavodiiron proteins. R. Frederick and D.M. Kurtz. Univ. of
Texas at San Antonio.
C135 998.5
The structural basis of the secondary function
of PMM1 in the presence of IMP. T. Ji, D. Dunaway-Mariano
and K.N. Allen. Boston Univ. and Univ. of New Mexico.
C136 998.6
Experimental and computational evidence
that ribonuclease A alters the transition state for RNA
2’-O-transphosphorylation. M.E. Harris, H. Gu, K-Y. Wong, B.
Radak, T. Dissanayake, D. Kellerman, S. Zhang, Q. Dai, M.
Miyagi, V.E. Anderson, D. York and J. Piccirilli. Case Western
Reserve Univ. Sch. of Med., Rutgers Univ., Piscataway and
Univ. of Chicago.
C137 998.7
Kinetic mechanism of human DNA ligase I. P.J.
O’Brien. Univ. of Michigan Med. Sch.
1000.MACROMOLECULAR FOLDING AND
FLUCTUATIONS
Poster
Exhibit Halls A-B
C144 1000.1 Identification of the DNA binding surface on the
SIRV capsid protein. H.E. Allgaier, R.E. Taurog, J.E. Johnson,
C.E. Rohlman and B.R. Szymczyna. Albion Col., MI, The
Scripps Res. Inst. and Western Michigan Univ.
1001.MOLECULAR MOTOR PROTEINS AND PUMPS
Poster
Exhibit Halls A-B
C145 1001.1 Myo1c, an unconventional motor that maintains
glomerular filtration function. E. Arif, L. Mallik, Y.S. Rathore,
B. Kumari, M. Ostap, F.N.U. Ashish, L.B. Holzman and D.
Nihalani. Univ. of Pennsylvania and CSIR-Inst. of Microbial
Technol., India.
C146 1001.2 Can a b/delta fusion protein replace individual
b and delta subunits of ATP synthase in Escherichia coli? C.S.
Gajadeera and J. Weber. Texas Tech Univ. and Texas Tech
Univ. Hlth. Sci. Ctr.
333
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BIOCHEMISTRYTUESDAY
C147 1001.3 Structural model of a2-subunit N-terminus and
its binding interface for cytohesin-2: implication for regulation of
V-ATPase function. M. Merkulova, H. Hosokawa, A. Bakulina,
P.V. Dip, Y.R. Thaker, A. Khatri, D.A. Ausiello, G. Grüber and
V. Marshansky. Massachusetts Gen. Hosp., Harvard Med.
Sch., State Res. Ctr. Virol. Biotech., Kolatsovo, Russia and
Nanyang Technol. Univ., Singapore.
1002.MULTIENZYME COMPLEXES
Poster
Exhibit Halls A-B
C148 1002.1 C1- tetrahydrofolate synthase contribution to
1C metabolism. D. Blemur , M. Field and P. Stover. Cornell
Univ.
C149 1002.2 NMR studies of the N-terminal domains of E2
component of human pyruvate dehydrogenase complex. S.
Kumaran, B. Birkaya, M. Patel and F. Jordan. Rutgers Univ.
and Univ. at Buffalo SUNY.
C150 1002.3 Investigation of protein-protein interactions in
the pyruvate dehydrogenase complex from Escherichia coli by
hydrogen/deuterium exchange mass spectrometry. J. Wang,
N.S. Nemeria and F. Jordan. Rutgers Univ., Newark.
C151 1002.4 Develop spatially-interactive multienzyme
complex on selfassembled DNA nanostructures. J. Fu.
Biodesign at Arizona State Univ.
1003.PROTEIN INTERACTIONS IN CATALYSIS
Poster
Exhibit Halls A-B
C152 1003.1 Thermodynamics and kinetics of the
interactions of calmodulin with Orai. C-C. Wei, S. Shakya, D.
Jensen and K. Bennett. Southern Illinois Univ. Edwardsville.
1004.REGULATION AND ALLOSTERISM
Poster
Exhibit Halls A-B
C153 1004.1 The allosteric regulation of phenylalanine
hydroxylase provides a foundation for new PKU therapies.
E.K. Jaffe, L. Stith, S.H. Lawrence, M. Andrake and R.L.
Dunbrack. Fox Chase Cancer Ctr., Temple Hlth.
C154 1004.2 Probing the effects of cofactor and substrate
on conformation and flexibility of human pGDH. C. Roach and
E. Bell. Univ. of Richmond.
C155 1004.3 Regulation of assembly of bipolar myosin II
filaments. A. Kandel, R. Frei and K. Prehoda. Univ. of Florida
and Univ. of Oregon.
334
C156 1004.4 Mutations found in patients Leber’s congenital
amaurosis disrupt retinal guanylate cyclase interaction with
rhodopsin in vitro; involvement in phototransduction. V.A.
Bondarenko and K. Jones. Touro Univ. Nevada and Touro
Univ. Nevda Col. of Osteo. Med.
C157 1004.5 New evidence for dimerization of the short
variant of PLA2g6, and regulation of its catalytic activity by
Ca2+/calmodulin and Ca2+ influx factor. S. Korolev, P. Csutora,
K. Peter, O. Koroleva, P. Subramanya, K. Malley and V.M.
Bolotina. Saint Louis Univ. Sch. of Med. and Boston Univ. Sch.
of Med.
C158 1004.6 Structure-function studies of the ADPglucose
pyrophosphorylase from Thermodesulfovibrio yellowstonii. M.
Susoeff, E. Yik, S. Kaur, G. Dua, M. Badal, A. Orry and C.R.
Meyer. California State Univ., Fullerton and Molsoft LLC, San
Diego.
C159 1004.7 Use of recombinent casein peptides as
inhibitors of spPEP. S. Basak and B. Clack. Stephen F. Austin
State Univ.
C160 1004.8 Pyruvate
revisited
as
a
synergistic
secondary activator of the Escherichia coli ADP-glucose
pyrophosphorylase. M.A. Ballicora, M. Asención Diez and
A.A. Iglesias. Loyola Univ. Chicago and Natl. Univ. del Litoral,
Argentina.
C161 1004.9 The phage e34 repressor binds to a unique
operator. J.D. Williams, D. Jackson and R. Villafane. Alabama
State Univ. and Huntingdon Col.
C162 1004.10 The importance of a loop structure in ATP
apparent affinity and allosteric activation of Escherichia coli
ADP-glucose pyrophosphorylase. B.L. Hill, J. Wong, J. FrisbyZedan, B. May and M.A. Ballicora. Loyola Univ. Chicago.
C163 1004.11 Probing the role of E304 in the allosteric
site of ADPglucose pyrophosphorylase from Agrobacterium
tumefaciens. S. Bor, H. Karzai, K. Chastain, A. Orry and C.R.
Meyer. California State Univ., Fullerton and Molsoft LLC, San
Diego.
C164 1004.12 Small crosslink may stabilize P22 tail protein at
N-terminus. C. Palmer, S. Johnson, D. Dean and R. Villafane.
Alabama State Univ. and Huntingdon Col.
1005.ROLE OF DYNAMICS IN ENZYME CATALYSIS
Poster
Exhibit Halls A-B
C165 1005.1 Structural analysis of an intein from an extreme
thermophile. J.E. Williams, J.N. Reitter and K.V. Mills. Col. of
the Holy Cross.
C166 1005.2 The role of an extended beta-sheet in
stabilizing the structure of a thermophilic intein. K.M. Colelli,
J.M. Pusztay, J.N. Reitter and K.V. Mills. Col. of the Holy
Cross.
TUESDAYBIOCHEMISTRY
1006.BIOPHYSICAL METHODS
1008.METABOLIC NETWORKS
Poster
Poster
Exhibit Halls A-B
Exhibit Halls A-B
C167 1006.1 Measurement of urinary catecholamines for
mice. E.A. Smith, A.L. Schwartz, T.L. Garrett and J.B. Lucot.
Wright State Univ.
C168 1006.2 Novel gold labeling reagent to localize protein
in macromolecular assemblies. K.C. Anthony, C. You, J.
Piehler and D. Pomeranz Krummel. Brandeis Univ. and Univ.
of Osnabrück, Germany.
C169 1006.3 Antibacterial activities of copper, silver and
carbon nanoparticles in sock fabric. Y.G. Gete and R. Walker.
Metropolitan State Univ. of Denver.
C170 1006.4 FTIR microspectroscopic analysis of sodium
butyrate induced differentiation in colon cancer cells in a timedependent manner. N. Simsek Ozek, S. Gok, S. Banerjee and
F. Severcan. Middle East Tech Univ., Turkey.
C171 1006.5 Neuronal networks on the nano alumina
templates. A. Islam. Northeastern Univ.
1007.CYTOCHROME P450
Poster
Exhibit Halls A-B
C172 1007.1 Metoclopramide is a substrate but not an
inactivator of CYP2D6. A.K. Bolles, E.D. Briggs, M.R. Livezey,
L.D. Nagy and L.L. Furge. Kalamazoo Col.
C173 1007.2 CYP2D6 is the major metabolizing enzyme of
metoclopramide. E.D. Briggs, A.K. Bolles, M.R. Livezey and
L.L. Furge. Kalamazoo Col.
C174 1007.3 Interaction of mechanism-based inactivators
with modified CYP2D6. M.R. Livezey, M.J. Hicks and L.L.
Furge. Kalamazoo Col.
C175 1007.4 Covalent modification of CYP2D6 following
inactivation by SCH66712. M.J. Hicks, M.R. Livezey and L.L.
Furge. Kalamazoo Col.
C176 1007.5 Regio- and stereo-selective oxidation of
fluorinated substrates by recombinant cytochrome P450 BM3
variants. S.S-F. Yu, L-L. Wu, C-H. Chiang, R. Ramu, C-L. Yang,
K.Y. Ng, W-I. Luo and S.I. Chan. Inst. of Chem., Acad. Sinica,
Taipei, Natl. Cheng Kung Univ. and Natl. Taiwan Univ. of Sci.
and Technol., Taiwan.
C177 1007.6 Regulation of phase I and phase II enzyme
gene expressions and their activities by caffeic acid, major
compound of Perilla frutescens. S-Y. Yang, J-H. Kang, H-Y.
Jung, J-E. Yang and K-W. Lee. Korea Univ.
C178 1007.7 Metabolism of cyclophosphamide by CYP2B6
and associated polymorphisms. J.M. Abbott, D. Calinski and
P. Hollenberg. Kalamazoo Col. and Univ. of Michigan Med.
Sch.
C179 1007.8 Cytochrome P450 autophagy: activation by
acute hepatic heme depletion. Y. Liu and M.A. Correia. UCSF.
C180 1008.1 Metabolic responses of the aerobic anoxygenic
phototrophic bacterium Roseobacter denitrificans during
photoheterotrophic and heterotrophic growth. J.K-H. Tang.
Clark Univ., MA.
1009.METABOLIC REGULATION
Poster
Exhibit Halls A-B
C181 1009.1 Sickle hemoglobin disturbs normal coupling
between erythrocyte O2 content, glycolysis and antioxidant
capacity. S.C. Rogers, J. Ross, A. d’Avignon, L. Gibbons, M.
Hassan, D. McLaughlin, S. Griffin, T. Neumayr, M. DeBaun,
M. DeBaun and A. Doctor. Washington Univ. in St. Louis and
Vanderbilt Univ.
C182 1009.2 Generation of an inducible arginase-1 deficient
mouse model. K. Mukherjee, L.L. Ballantyne, A. Sin, T. St.
Amand and C.D. Funk. Queen’s Univ., Canada.
C183 1009.3 Hyperargininemia in an inducible arginase-1deficient mouse model. A. Sin, L.L. Ballantyne, K. Mukherjee,
T. St. Amand, C. McCracken, V. Levandovskiy, A. Schulze
and C.D. Funk. Queen’s Univ., Canada and The Hosp. for Sick
Children, Toronto.
C184 1009.4 mTOR complex 2 regulation of hepatic gene
expression. J.M. Boylan, D.W. Lamming, N. Neretti, J.
Ferreira, D.M. Sabatini and P.A. Gruppuso. Brown Univ. and
Whitehead Inst. for Biomed. Res., Cambridge, MA.
C185 1009.5 Visualizing the effect of iron on the localization
of intracellular ferritin in mosquito cells. Z.R. Conley, D. Geiser
and J. Winzerling. Univ. of Arizona.
C186 1009.6 Structure of the carnitine palmitoyltransferase1A gene in rats, mice and humans. G.A. Cook and E.A. Park.
Univ. of Hlth. Sci. Ctr.
1010.METABOLISM AND DIABETES
Poster
Exhibit Halls A-B
C187 1010.1 Role of the sphingolipid biostat in pancreatic
bcell apoptosis induced by gluco-lipotoxicity. N. Coant, J. Veret,
P. Giussani, B. Portha, E.V. Berdyshev and H. Le Stunff.
Univ. Paris Diderot, France, LITA-Segrate, Milan and Univ. of
Illinois at Chicago.
C188 1010.2 Small-molecule
modulators
of
Nkx6.1
expression in pancreatic progenitor cells during directed
differentiation of human embryonic stem cell to insulin
producing beta cells. Q. Peterson and D. Melton. Harvard
Univ.
335
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C189 1010.3 Elevated hepatic fatty acid elongase-5
attenuates fatty liver in high fat diet induced obese mice. S.
Tripathy, R.D. Stevens, J.R. Bain, C.B. Newgard and D.B.
Jump. Oregon State Univ. and Duke Univ. Med. Ctr.
C190 1010.4 Ultraviolet B radiation enhances glycation of
human serum albumin and the formation of CML in vitro. W.
Liu, M.A. Cohenford, L. Frost and J.A. Dain. Univ. of Rhode
Island and Marshall Univ.
C191 1010.5 The dysregulation of AMPK suppresses
phosphorylation of sterol regulatory element binding protein
and increases its activity in the development of atherosclerosis
in pig and human diabetes. M. Zang, Y. Li, S. Xu, B. Jiang and
R.A. Cohen. Boston Univ. Sch. of Med.
C192 1010.6 The miR-696 contributes to insulin resistance
by reducing mitochondrial function and antioxidant capacity in
skeletal muscle cells. A.L. Queiroz, T.A. Sousa, B.G. Teodoro,
L.M. Bomfim, I.H. Sampaio and L.R. Silveira. Fac. of Med.,
Ribeirão Preto-Univ. of São Paulo.
C193 1010.7 Mouse models of insulin resistance: what have
we learned? A.E. Bunner and N.D. Barnard. Physicians Cmte.
for Responsible Med., Washington, DC.
C194 1010.8 COMP-Ang1 preserves vasculature and
prevents vision loss in diabetic retinopathy. J.M. Cahoon, P.R.
Olson, X.H. Zhang, M.M. Flood, B. Archer and B.K. Ambati.
Univ. of Utah.
C195 1010.9 Effects of oleate and inflammatory cytokines
on dermal fibroblasts in type 1 diabetics. A.R. Jones IV, J.T.
Deeney and B. Corkey. Boston Univ. Med. Ctr.
C196 1010.10 Inhibition of mono-acyl-glycerol lipase by JZL184 results in glucolipotoxicity in pancreatic b-cells. C. Berdan,
B.E. Corkey and J.T. Deeney. Boston Univ. Med. Ctr.
C197 1010.11 Chronic exposure of clonal pancreatic b-cells
(INS-1 832/13) to pyruvate inhibits glucose-induced insulin
secretion. N.E. Burritt, B. Corkey and J.T. Deeney. Boston
Med. Ctr.
C198 1010.12 Metabolite predictors of HOMA in at-risk for
mobility disability elderly subjects. M.S. Lustgarten and R.A.
Fielding. Tufts Univ., Boston.
C199 1010.13 Iron stimulates insulin secretion in clonal
pancreatic b-cells and dissociated rat islets. K.A. Erion, T.
Ferrante, B. Corkey and J. Deeney. Boston Univ. Sch. of Med.
C200 1010.14 Cystathionine-g-lyase (CSE) activation and
H2S formation mediate the effect of vitamin D on glucose
transporter 4 translocation and glucose utilization in high
glucose treated 3T3L1 adipocytes. P. Manna and S.K. Jain.
LSU Hlth. Sci. Ctr., Shreveport.
C201 1010.15 Deficiency of sphingosine kinase 1 ameliorates
hepatic steatosis and inflammation in diet-induced obesity. T.
Geng, A. Sutter, D. Lewin, J. Ross, K.D. Chavin and L.A.
Cowart. Med. Univ. of South Carolina.
C202 1010.16 Hypoglycemia increases glycolytic metabolism
in the rat ventromedial hypothalamus. J. Mun, A. Cooper, J.
Cavaretta and J.L. Beverly. Univ. of Illinois, Urbana.
C203 1010.17 Mesenchymal stem cell therapy to promote
peripheral tissue insulin sensitivity in the high-fat fed,
myocardial infarcted mouse. C. Hughey, L. Ma, F.D. James,
D.P. Bracy, D.H. Wasserman, J.N. Rottman and J. Shearer.
Univ. of Calgary, Canada and Vanderbilt Univ.
Visit the Exhibits
336
1011.MITOCHONDRIA IN HEALTH AND DISEASE
Poster
Exhibit Halls A-B
C204 1011.1 High fat feeding enhances the ability of
mesenchymal stem cell therapy to modulate mitochondria in
the infarcted heart. C. Hughey, L. Ma, F.D. James, D.P. Bracy,
D.H. Wasserman, J.N. Rottman and J. Shearer. Univ. of
Calgary, Canada and Vanderbilt Univ.
C205 1011.2 Aerobic exercise training during pregnancy
improves mitochondrial function in human placenta. R.
Ramírez-Vélez. Univ. Manuela Beltrán, Colombia.
C206 1011.3 Mitochondrial
sensitivity
to
ADP
in
permeabilized fibers changed as a function of cardiac muscle
compartments: left/right atria and ventricles of sheep heart.
M. Chapolard, F. Vaillant, P. Jais, M. Haissaguerre, P. Dos
Santos, P. Diolez and V. Deschodt-Arsac. INSERM U1045,
Bordeaux Segalen Univ.
C207 1011.4 Can perinatal undernutrition alter mitochondrial
function and metabolism in the adult liver? C.J. Lagranha, R.
Silva-Filho, C. Freitas, A. Silva, L. Nascimento, A.C. Leite,
M.B. Maia and M.P. Fernandes. Fed. Univ. of Pernambuco,
Vitoria de Santo Antão and Recife, Brazil.
C208 1011.5 Metformin
attenuates
cardiomyocyte
hypertrophy through mitochondria: reciprocal interaction
between AMPKk and angiotensin II type 1 receptor. J. SotoHernández and S. Javadov. Sch. of Med., Univ. of Puerto
Rico.
C209 1011.6 Mammalian Ste20-like protein kinase 3
mediates the bioenergetics of mitochondria. C-J. Yuan and
C-Y. Chen. Natl. Chiao Tung Univ., Taiwan.
C210 1011.7 Palm fruit juice phenolics reduce the number of
mutations caused by 3’-azido-3’-deoxythymidine treatment in a
cultured human cell line. A. Osborne, A. Stopa, M. Solomon,
L. Wangh and K.C. Hayes. Brandeis Univ.
C211 1011.8 Dietary avocado oil prevents the impairment
in the complex III and ROS production in kidney mitochondria
from diabetic rats by improving the electron flow through
cytochrome c1. C. Cortes-Rojo, A. Saavedra-Molina, C.A.
Samano-Garcia, O. Ortiz-Avila, E. Calderon-Cortes, D.
Ortiz-Madrigal, G. Hernandez-Mata and A.R. RodriguezOrozco. Univ. Michoacana of San Nicolas de Hidalgo, Mexico.
C212 1011.9 Using in-line probing to characterize pathogenic
mutations in human mitochondrial tRNAs. B. Still, K. Her and
J. Chihade. Carleton Col., MN.
C213 1011.10 Using long-extension PCR assay to detect
large-scale deletions in the mitochondrial DNA. W.K.
Pogozelski, S. Chiappone, C. Evans and R. O’Donnell.
SUNY Geneseo.
C214 1011.11 DNA oxidation in regulatory D-loop region of
the mitochondrial genome is important for hypoxia-induced
mitochondrial biogenesis in rat pulmonary artery endothelial
cells. M.V. Ruchko, O.M. Gorodnya, M.N. Gillespie and V.M.
Pastukh. Univ. of South Alabama.
C215 1011.12 Selective targeting of cytochrome C–cardiolipin
complex to protect mitochondrial cristae and inhibit apoptosis.
A.V. Birk, S. Liu, Y. Soong, J.D. Warren and H.H. Szeto. Weill
Cornell Med. Col.
C216 1011.13 Modulation of Bcl-2 proteins in an in vitro model
of sepsis. J.A. Crum and V. Del Gaizo Moore. Elon Univ., NC.
TUESDAYBIOCHEMISTRY
C217 1011.14 Thiol-based antioxidants trigger transient
mitochondrial oxidation. J.N. Beaudoin, V.L. Kolossov, W.
Hanafin, S. DiLiberto, Jr., P.G. Kenis and H.R. Gaskins. Univ.
of Illinois at Urbana-Champaign.
C218 1011.15 Effect of avocado oil on fatty acid profile and
ROS generation in liver and aortic mitochondria from diabetic
rats. O. Ortiz-Avila, C. Samano-Garcia, E. Calderon-Cortes,
A. Saavedra-Molina and C. Cortes-Rojo. Univ. Michoacana
de San Nicolas de Hidalgo, Mexico.
1012.NUCLEAR RECEPTORS IN METABOLIC
SYNDROMES
Poster
Exhibit Halls A-B
C219 1012.1 Association of genetic polymorphism of
peroxisome proliferator-activated receptor-gamma gene and
polycystic ovary syndrome. N.S.E. Hemimi, I.A. Shaafie and
H.H.A. Alshawa. Dubai Med. Col. and Gulf Med. Col., United
Arab Emirates.
C220 1012.2 Inhibition of secretory phospholipase A2 group
IIa by thyroid hormone. P. Sharma, S. Thakran, X. Deng,
M.B. Elam and E.A. Park. Univ. of Tennessee Hlth. Sci. Ctr.,
Memphis.
C221 1012.3 Retinoid X receptor alpha interaction with
sugars. F.L. Soman, C. de Jesus Piva and H.A. Hostetler.
Boonshoft Sch. of Med., Wright State Univ.
1013.ASSEMBLY AND CONTROL OF DYNAMIC
PROTEIN COMPLEXES
Poster
Exhibit Halls A-B
C222 1013.1 Crystal structure and in vitro analysis of
human IQGAP1 calponin homology domain: implication for its
interactions with Ca2+ bound calmodulin and F-actin. J. Liu,
V. Kurella, L.F. LeCour and D.K. Worthylake. LSU Sch. of
Med.,New Orleans.
C223 1013.2 Characterization of a novel interaction between
BLIP-II and Staphylococcus aureus PBP2a. C.J. Adamski,
D-C. Chow, N. Brown and T. Palzkill. Baylor Col. of Med.
C224 1013.3 GMPCPP and paclitaxel effect on microtubule
stiffness. S. Cheng and Z. Donhauser. Vassar Col.
C225 1013.4 Monitoring the structural dynamics of
LRRK2 using split-luciferase protein-fragment-assisted
complementation. J. Nardozzi, O. Baker, S. Wong and M.J.
LaVoie. Harvard Med. Sch. and Brigham and Women’s Hosp.
1014.CHEMISTRY AND CELL BIOLOGY OF NATURAL
PRODUCTS
Poster
Exhibit Halls A-B
C226 1014.1 Tissue culture of the Egyptian cotton cultivars:
production and morphological heterogeneity of primary callus
tissues. H.M. Younis, M.E-T.I. Badawy and H.M.S. Darrag.
Alexandria Univ., Egypt.
C227 1014.2 Inhibitory effects of Alaria fistulosa uronan on
tyrosinase activity and melanin synthesis. Y.H. Lee, B.H. Yoon
and M.J. Ku. Kosin Med. Col. and Tongmyong Univ., South
Korea.
C228 1014.3 Synthesis of novel Pb, Mn, Zn, Ag, Co and
Cu complexes with coumarine derivative moiety and their
antibacterial activities. S.R. Govori, A. Haziri, F. Palucaj, A.
Krasniqi, A. Rifati and H. Ibrahimi. Fac. of Nat. Sci. and Univ.
of Prishtina, Kosovo.
C229 1014.4 Evaluation of acute toxicity (in mice) and
subchronic toxicity (in rats) of aqueous extract of Tapinanthus
bangwensis leaves grown on orange trees. S.C. Nwoke, A.O.
Magbagdeola,, A.O. Ebuehi, N.A. Imaga, M. Omojufehinsi, S.
Gbotolorun,, G.O. Ajayi, and A. Ani. Univ. of Lagos, Nigeria.
C230 1014.5 The biogeochemical chlorine cycle in forest
ecosystems. A. Pirovano and A. Leri. Marymount Manhattan
Col.
C231 1014.6 Sensitization of NCI-H460 cells to anticancer
drugs with aminoglycosides. M. Cuccarese. Northeastern
Univ.
C232 1014.7 Structure activity relationship study of the
cleistriosides and cleistetrosides for antibacterial/anticancer
activity. P. Shi. Northeastern Univ.
C233 1014.8 C3’/C4’-stereochemical effects of digitoxigenin
a-L-/a-D-glycoside in cancer cytotoxicity. S. McKenna and J.
Hinds. Northeastern Univ.
C234 1014.9 Synergistic effects of digitoxin analogues in
combination with chemotherapeutic drugs. J.W. Hinds and S.
McKenna. Northeastern Univ.
C235 1014.10 Effects of aloe vera components on the reninangiotensin system in human mesangial cells. L.S. Arita, L.
Santos, R. Yokota, M.M. Tanae, D.S. Aragão, M.D. Nogueira,
R.S. Banchi, L.E. Matsumoto, D.Y. Arita, T.S. Cunha, M.T.R.
Lima-Landman and D.E. Casarini. Fed. Univ. of São Paulo
and Tulane Univ.
1015.PROTEIN-SMALL MOLECULE INTERACTIONS
Poster
Exhibit Halls A-B
C236 1015.1 Understanding protein-protein interaction
network: a case study with glutaminase interacting protein. M.
Ovee, D. Zoetewey, M. Banerjee, R. Bhaskaran, S. Mohanty,
S. Zencir and Z. Topcu. Auburn Univ. and Ege Univ., Turkey.
337
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C237 1015.2 Specific interaction of the TCERG1 FF4-6
tandem repeat domains with RNA polymerase II requires
simultaneous phosphorylation at Ser2, Ser5 and Ser7 of the
CTD. J. Liu, S. Fan, C-J. Lee, A.L. Greenleaf and P. Zhou.
Duke Univ. Med. Ctr. and MRC Lab. of Molec. Biol., Cambridge,
U.K.
C238 1015.3 Homogeneous, sulfated oligosaccharides from
glycosaminoglycans activate promatrilysin (proMMP-7) largely
by co-localization. Y.G. Fulcher, F. Zhang, R.J. Linhardt,
R. Sanganna Gari, S.H. Prior, Y.J. Jeong, G.M. King and
S.R. Van Doren. Univ. of Missouri-Columbia and Rensselaer
Polytech Inst.
C239 1015.4 Mycobacterium smegmatis Ku binds zinc. A.K.
Kushwaha and A. Grove. LSU.
C240 1015.5 The relationship between function and
structure of the heme-scavenging protein IsdX1. A. Kenrick, K.
Polzin and M. McEvoy. Univ. of Arizona.
C241 1015.6 Guanosine-5’-triphosphate
regulates
the
interaction between MciZ and FtsZ. S. Ray, A. Kumar and D.
Panda. Indian Inst. of Technol. Bombay.
C242 1015.7 Structure-based drug design of inhibitors of
the CD23 and immunoglobulin E interaction. M.O.Y. Pang, J.
McDonnell and A. Beavil. King’s Col. London.
C243 1015.8 Design and characterization of an EHD1
inhibitor. J. Baleja, T. Corlin, A. Kamens, A. Alt-Holland and
J. Kritzer. Tufts Univ. Schs. of Med. and Dent Med. and Tufts
Univ.
C244 1015.9 The effect of conformational changes on
non-coordinated water occupancy associated with R and T
allosteric states of carp hemoglobin. W. Salameh, E. Padilla,
P.N. Tipgunlakant, R.A. Goldbeck and D.S. Kliger. San
Francisco State Univ. and Univ. of California, Santa Cruz.
1016.CELL AND ORGANELLE DYNAMICS
Poster
Exhibit Halls A-B
C245 1016.1 The role of the C-terminus and transmembrane
segments in facilitating atlastin-mediated endoplasmic
reticulum fusion. T.Y. Liu, X. Bian, S. Sun, X. Hu, R.W. Klemm,
W.A. Prinz, T.A. Rapoport and J. Hu. Harvard Med. Sch.,
HHMI, Col. of Life Sci., Nankai Univ. and Tianjin Key Lab. of
Protein Sci., Tianjin, China and NIDDK, NIH.
C246 1016.2 Saccharomyces cerevisiae Env7 is a novel
serine/threonine kinase 16-related protein kinase and
negatively regulates organelle fusion at the lysosomal vacuole.
E. Gharakhanian, S. Manandhar, F. Ricarte and S. Cocca.
California State Univ., Long Beach.
C247 1016.3 An in vitro model of T cell exit from the T cell
zone mediated by sub-regional co-existing CCL19 and CCL21
fields in lymph nodes. S. Andalur Nandagopal and F. Lin.
Univ. of Manitoba.
338
1017.MEMBRANE TRANSPORT
Poster
Exhibit Halls A-B
C248 1017.1 Mechanisms of Cu+ transfer from soluble
Cu+ chaperones to transmembrane transport ATPases.
T.N. Padilla-Benavides, C.J. McCann and J.M. Arguello.
Worcester Polytech Inst.
C249 1017.2 A putative Fe+3/phytosiderophore transporter
isolated from oats (Avena sativa). G.T. Davis and M.
Stocksdale. Bloomsburg Univ., PA and Earlham Col., IN.
C250 1017.3 Nucleotide binding stabilizes Na,K-ATPase
quaternary structure and facilitates trafficking to plasma
membrane. C. Galva, K.R. Louis and C. Gatto. Sch. of Biol.
Sci., Illinois State Univ. and Univ. of Illinois, Urbana.
C251 1017.4 Identification of TMEM184A in vascular
endothelial and smooth muscle cells. J.B. Slee and L.J. LoweKrentz. Lehigh Univ.
C252 1017.5 Observation of TonB motion using fluorescence
anisotropy. L.D. Jordan, Y. Zhou, C.R. Smallwood, Y. Lill, K.P.
Ritchie, W.T. Yip, S.M. Newton and P.E. Klebba. Kansas State
Univ., Univ. of Oklahoma and Purdue Univ.
C253 1017.6 Endosomal sorting of VAMP3 is regulated
by phosphatidylinositol 4-kinase IIa. M. Jovic, M. Kean, A-C.
Gingras, J. Brill and T. Balla. NICHD, NIH and Samuel
Lunenfeld Res. Inst. and The Hosp. for Sick Children, Toronto.
C254 1017.7 Postnatal injection of homocysteic acid in rats
leads to the development of schizophrenia-like behaviors. G.
Flores, C. Barney and L. Chase. Hope Col., MI.
C255 1017.8 Real time trafficking of System xc- in COS-7
cells. C. Cramer and L. Chase. Hope Col., MI.
C256 1017.9 Identification of putative trafficking motifs in
System xc-. S. Lang, A. Georges and L. Chase. Hope Col., MI.
C257 1017.10 Cell surface expression of xCT is regulated by
the Akt signaling pathway. L. Chase, D. Smith and N. Schiller.
Hope Col., MI.
C258 1017.11 Vitamin E and nonalcoholic fatty liver disease.
V. Thakur, L. Ulatowski, R. Parker, R. Zhang, X. Liu and
D. Manor. Case Western Reserve Univ., Cornell Univ. and
Cleveland Clin. Fndn.
C259 1017.12 Global deletion of stearoyl-CoA desaturase-2
enhances glucose tolerance. L. O’Neill and J. Ntambi. Univ. of
Wisconsin-Madison.
C260 1017.13 Characterization of the role of long chain acylCoA synthetase 6 in skeletal muscle energy metabolism. S.Y.
Bu. Kyungil Univ., South Korea.
C261 1017.14 When fed a high-fat diet,GPAT4-/- mice have
an increased metabolic rate and impaired growth and weight
gain. D. Cooper and R.A. Coleman. Univ. of North Carolina at
Chapel Hill.
TUESDAYBIOCHEMISTRY
1018.LIPID SECOND MESSENGERS
Poster
Exhibit Halls A-B
C262 1018.1 cAMP-stimulated expression of DGKq requires
steroidogenic factor-1 and sterol regulatory element binding
protein. K. Cai and M. Sewer. Skaggs Sch. of Pharm. and
Pharmaceut. Sci., UCSD.
C263 1018.2 The basis of the substrate specificity of
the epsilon isoform of human diacylglycerol kinase is not a
consequence of competing hydrolysis of ATP. R.M. Epand,
A. Prodeus, B. Berno and M.K. Topham. McMaster Univ.,
Canada and Univ. of Utah.
C264 1018.3 Phospholipase Cb1 is linked to RNA
interference of specific genes through translin-associated
factor X. S. Scarlata, F. Philip and Y. Guo. Stony Brook Univ.
1019.LIPID SIGNALING
Poster
Exhibit Halls A-B
C265 1019.1 Characterization of tocopherol kinase activity
in primary human coronary artery smooth muscle cells. J-M.
Zingg, M. Meydani and A. Azzi. Tufts Univ.
C266 1019.2 Expression
and
characterization
of
recombinant neutral sphingomyelinase 2 in Escherichia coli:
evidence of sensitivity to redox state. P.P. Dotson II and M.
Nikolova-Karakashian. Univ. of Kentucky.
C267 1019.3 Searching the extracellular domain of CD36 for
fatty acid binding by surface plasmon resonance. A. Jay, A.
Chen and J.A. Hamilton. Boston Univ.
C268 1019.4 The role of endosomal phosphoinositides in
phagocytosis, phagosome maturation and the endosomal
system in macrophages. G.H.E. Kim, M. Dayam and R.
Botelho. Ryerson Univ., Canada.
C269 1019.5 Vac14 multimerization is required for Fab1
complex assembly and function. S.C.Y. Ho, T. Alghamdi and
R.J. Botelho. Ryerson Univ., Canada.
C270 1019.6 Membrane ultrastructure modulates immune
cell signaling. A. Pralle, H. Huang and M. Simsek. Univ. at
Buffalo.
1020.LIPID STORAGE
Poster
Exhibit Halls A-B
C271 1020.1 Cholesteryl ester transfer protein deficiency in
adipocytes disrupts triglyceride metabolism in multiple ways.
D.J. Greene and R.E. Morton. Lerner Res. Inst., Cleveland
Clin.
C272 1020.2 Both full-length and exon 9-deleted human
cholesteryl ester transfer protein isoforms are involved in
cellular lipid homeostasis. L. Izem and R.E. Morton. Lerner
Res. Inst., Cleveland Clin.
C273 1020.3 Characterization of the proteome of cytoplamic
lipid droplets in enterocytes in response to dietary fat. T.
D’Aquila, D. Sirohi, R.J. Kuhn and K.K. Buhman. Purdue
Univ.
C274 1020.4 Characterization of a perilipin 5 splice variant.
T.C. Hubbell, D.M. DuBreuil and J.T. Tansey. Otterbein Univ.,
OH.
1021.PROTEIN-LIPID INTERACTIONS
Poster
Exhibit Halls A-B
C275 1021.1 Acrolein, a component of tobacco smoke and
age-related oxidative stress disrupts structure and function
of apolipoprotein E. T.N. Tran, Y.Y. Lee, K. Uchida and V.
Narayanaswami. California State Univ., Long Beach, and
Grad. Sch. of Agr. Sci., Nagoya Univ., Japan.
C276 1021.2 Fatty acids and their thioester derivatives
as potential endogenous ligands of LXRa. G.V. Hines, A.
Kaliappan, S.D. Rider, Jr. and H.A. Hostetler. Boonshoft Sch.
of Med., Wright State Univ.
C277 1021.3 A characterization of the modular nature
of histone-derived antimicrobial peptides. M.E. Bustillo,
M.A. LaBouyer, A.L. Fischer, D.C. Webb and D.E. Elmore.
Wellesley Col.
C278 1021.4 A modular approach to the histone H2A family
of antimicrobial peptides. A.L. Fischer, M. Bustillo and D.E.
Elmore. Wellesley Col.
C279 1021.5 Engineering a specific phosphatidylcholine
binding site motif into a phosphatidylinositol-specific
phospholipase C. R. Goldstein, J. Cheng, B. Stec, A.
Gershenson and M.F. Roberts. Boston Col., SanfordBurnham Med. Res. Inst., La Jolla and Univ. of Massachusetts
Amherst.
C280 1021.6 Role of arginine and lysine in the antimicrobial
mechanism of histone-derived peptides. K. Cutrona and D.
Elmore. Wellesley Col.
C281 1021.7 Biochemical analysis unveils the mechanism
of the interaction between Hsp70s and lipids. C. McCallister
and N. Nikolaidis. California State Univ., Fullerton.
C282 1021.8 Spatial and temporal regulation of the Nedd4
family ubiquitin ligases through phospholipid binding. J. Scott
and R.V. Stahelin. Univ. of Notre Dame and Indiana Univ. Sch.
of Med. South Bend.
C283 1021.9 Lipid binding properties of Ebola virus matrix
protein VP40. S. Yong, J.L. Scott and R.V. Stahelin. Univ. of
Notre Dame and Indiana Univ. Sch. of Med. South Bend.
C284 1021.10 The interaction of Hsp70s and lipids is
conserved from bacteria to humans. M.C. Siracusa and N.
Nikolaidis. California State Univ., Fullerton.
C285 1021.11 Expression and purification of a MORN fusion
protein from Pseudomonas aeruginosa. C.C. Anderson, L.C.
MacDonald, J.B. Nice, B.W. Berger and C.N. Streu. St.
Mary’s Col. of Maryland and Lehigh Univ.
339
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1022.STRESS AND LIPID METABOLISM
Poster
Exhibit Halls A-B
C293 1025.2 Structural insights into the role of BamA in the
biogenesis of beta-barrel membrane proteins in Gram-negative
bacteria. N. Noinaj, A. Kuszak, J.C. Gumbart, P. Lukacik, H.
Chang, N. Easley, T. Lithgow and S.K. Buchanan. NIDDK,
NIH, Georgia Tech, Diamond Light Source Ltd, Oxford, FDA,
Rockville and Monarch Univ., Australia.
C286 1022.1 Modulating lipid fate controls lipotoxicity in
palmitate-treated hepatic cells. A. Leamy, M. Shiota and J.
Young. Vanderbilt Univ.
C287 1022.2 Protective effects of coenzyme Q10 on
dystrophic muscle cells. E. Minatel, D.S. Mizobuti, A.B.
Macedo and L.H.R. Moraes. Univ. of Campinas, Brazil.
1023.STRUCTURAL BIOLOGY AND MECHANISMS OF
MEMBRANE LIPID ASSEMBLY
Poster
Exhibit Halls A-B
C288 1023.1 Probing the structure and function of ApoA-I
C-terminal domain during HDL formation. X. Mei and D.
Atkinson. Boston Univ. Sch. of Med.
C289 1023.2 Mechanisms of non-random sphingolipid
organization in the plasma membranes of fibroblast cells. M.L.
Kraft, H.A. Klitzing, J.F. Frisz, K. Kou, P.K. Weber and J.
Zimmerberg. Sch. of Chem. Sci., Univ. of Illinois at UrbanaChampaign, Lawrence Livermore Natl. Lab. and NICHD, NIH.
1024.LIPID DOMAINS AND LIPID RAFTS
Poster
Exhibit Halls A-B
C290 1024.1 The iron transport inhibitor ferristatin II induces
degradation of transferrin receptor-1. S.L. Byrne, P.D. Buckett,
J. Sanford, J. Chen, C. Enns and M. Wessling-Resnick.
Harvard Sch. of Publ. Hlth. and Oregon Hlth. & Sci. Univ.
C291 1024.2 Differential oligomeric nature of mEos2 and
mEos3.2 fluorescent proteins is consequential to diffusion and
confinement of membrane probes. E. Edwald and S.L. Veatch.
Univ. of Michigan.
1025.MEMBRANE PROTEIN SYNTHESIS, INSERTION
AND ASSEMBLY
Poster
Exhibit Halls A-B
C292 1025.1 Targeting of a mating machinery ATPase to
the cell membrane. M.P. Broulidakis, S.J. Laurer and M.B.
Berkmen. Suffolk Univ., MA.
340
1026.PROTEIN-LIPID INTERACTIONS AS
DETERMINANTS OF FUNCTION
Poster
Exhibit Halls A-B
C294 1026.1 Regulation of the ATP hydrolysis and transport
cycles of the P-glycoprotein multidrug transporter by sterols
and phospholipids. F.J. Sharom, A.T. Clay and P. Lu. Univ. of
Guelph, Canada.
C295 1026.2 Surprising phospholipid specificity of two blood
clotting proteins: factor VII and protein C. N. Tavoosi and J.H.
Morrissey. Univ. of Illinois at Urbana-Champaign.
C296 1026.3 The role of cardiolipin in defining the mammalian
ANT interactome. Y-W. Lu, M.G. Baile, T-C. Huang, A. Pandey
and S.M. Claypool. Johns Hopkins Univ. Sch. of Med.
1027.CELL CYCLE
Poster
Exhibit Halls A-B
C297 1027.1 Cell cycle regulation mechanism in pathogenic
yeast,
Cryptococcus
neoformans:
structure-function
relationship of G1 and G1/S cyclins homologue CnCln1. S.
Kawamoto, E.V. Virtudazo, A. Suganami and Y. Tamura.
Chiba Univ. Med. Mycol. Res. Ctr. and Grad. Sch. of Med.,
Japan.
C298 1027.2 Video time lapse imaging of mitotic catastrophe
events in response to thiopurines. S. Patel and D. Pittman.
Univ. of South Carolina and South Carolina Col. of Pharm.
C299 1027.3 Identification and characterization of mitotic
defect-related proteins (MDr1 and MDr2) necessary for bipolar
spindle assembly. K. Cheung and J. Torres. UCLA.
C300 1027.4 The disruption of the mitotic cell cycle exit by
inositolless death in S. cerevisiae. B.A. Hanson, P.O. O’Connor,
J. Frandina, J. Pittari, J. Munezero and V. Croglio. Canisius
Col., NY.
C301 1027.5 Paradoxical effects of metformin on the cell
cycle in L6 myoblasts. R. Parakhia and R.S. Ochs. St. John’s
Univ., NY.
C302 1027.6 Adiponectin receptor (ADIPOR1) signaling
ameliorates obesity-dependent cell cycle entry in MCF7 cells.
M. Connor and C. Theriau. York Univ., Canada.
C303 1027.7 The ubiquitin conjugating enzyme UbcH10
competes with UbcH3 for binding to the SCF complex, a
ubiquitin ligase involved in cell cycle progression. A.Y. Le
Feuvre, D. Afful, F. Shang and A. Taylor. USDA at Tufts Univ.
TUESDAYBIOCHEMISTRY
C304 1027.8 The SUMO ligase PIAS1 promotes the
progression and survival of solid tumors of different
histopathological origins. J.D. Constanzo, A. Rabellino, G.
Konstantinidou, K. Schuster and P. Scaglioni. Univ. of Texas
Southwestern Med. Ctr.
1028.CELL CYCLE AND GROWTH CONTROL
Poster
Exhibit Halls A-B
C305 1028.1 MED28 regulates cell growth through HMG
box-containing protein 1 in human breast cancer cells. N-T.
Hsieh, C-Y. Huang, Y-H. Chou, W.C. Ung and M-F. Lee. China
Med. Univ. and Chang Jung Christian Univ., Taiwan.
C306 1028.2 Cranberry proanthocyanidins affect human
prostate cancer cell growth via cell cycle arrest by modulating
expression of cell cycle regulators. R. Hurta, J. Kim, B.
McKeown, K. Patel and C. Neto. Univ. of Prince Edward Isl.,
Canada and Univ. of Massachusetts Dartmouth.
C307 1028.3 Artemisia princeps var. orientalis induces
cell cycle arrest accompanied by upregulation of p21,CIP1 and
caspase-dependent apoptosis in human breast carcinoma
cells. E-J. Choi and G-H. Kim. Duksung Women’s Univ., South
Korea.
C308 1028.4 Functional analysis of the interaction between
Kaposi sarcoma-associated herpes virus anti-apoptotic Bcl2 homolog and the human host pro-apoptotic protein, Bik. B.
Caruso, S. Walker and J. Roecklein-Canfield. Simmons Col.
C309 1028.5 Muscle enriched A-type lamin interacting
protein a novel regulator cardiac growth and function. M-E.
Cattin, E. Mak-Washburn and P.G. Burgon. Univ. of Ottawa
Heart Inst.
C310 1028.6 Effects of sulforaphane on three tumor cell
lines and one normal cell line. F. Jin, T. Terwilliger, J. Bosch
and R.W. O’Donnell. SUNY Geneseo.
C311 1028.7 Using carboxyfluorescein succinimidyl ester
to measure the effects of sulforaphane on cell division in a
human leukemia cell line. K. Lehner, O. Feliciano and R.W.
O’Donnell. SUNY Geneseo.
1029.CHECKPOINT MECHANISMS
Poster
Exhibit Halls A-B
C312 1029.1 Nuclear localized BMP2 promotes cell cycle
progression. B.A. Nichols, W.A. Goar, B.T. McCune and L.C.
Bridgewater. Brigham Young Univ.
1030.CYCLINS AND CYCLIN-DEPENDENT KINASES
Poster
Exhibit Halls A-B
C313 1030.1 The role of cyclin-dependent kinase 5 in insulin
exocytosis. A. Trye and A. Aguanno. Marymount Manhattan
Col.
C314 1030.2 Pentoxifylline
initiates
GSK-3b-induced
proteasomal degradation of cyclin D1 and arrests renal cancer
cells in the G1 phase. W. Cai, N.J. Mastrandrea, K.Y. Tham,
T.J. Monks and S.S. Lau. Univ. of Arizona Col. of Pharm.
C315 1030.3 Cyclin dependent kinase 5’s role in the
development of both insulin-positive and neuronal phenotypes.
D.E. Khost and A. Aguanno. Marymount Manhattan Col.
1031.MECHANISMS OF SIGNAL TRANSDUCTION II
Poster
Exhibit Halls A-B
Session I scheduled on Monday.
C316 1031.1 YAP mediates crosstalk between the Hippo
and PI(3)K–TOR pathways by suppressing PTEN via miR-29.
K.A. Tumaneng. UCSD.
C317 1031.2 A-kinase anchoring protein-Lbc coordinates
protein kinase A phosphorylation and inhibition of Src homology
2 domain-containing phosphatase 2. B.T. Burmeister, D.M.
Taglieri, L. Wang and G.K. Carnegie. Univ. of Illinois at
Chicago.
C318 1031.3 Specific mutations on the receptor-binding
interface of non-visual arrestins differently affect recruitment
by the NPY receptor family. L.E. Gimenez, S. Babilon, A.G.
Beck-Sickinger and V.V. Gurevich. Vanderbilt Univ. Med. Ctr.
and Leipzig Univ.
C319 1031.4 Analysis of MILLIPLEX® MAP NFkB signaling
using Luminex® xMAP® technology. J. Hwang, T. Warmke and
R. Wiese. EMD Millipore, St. Charles, MO.
C320 1031.5 Inhibition of ERK5 protects pulmonary fibrosis
via downregulation of TGF-b1-Smad signaling. S. Kim, S. Park,
J-H. Lim and C-H. Woo. Yeungnam Univ. and Ewha Womens
Univ., South Korea.
C321 1031.6 PAR-1 is a novel mechano-sensor transducing
laminar flow-mediated endothelial signaling. S. Kim, D. Nam, J.
Han and C-H. Woo. Yeungnam Univ., South Korea.
C322 1031.7 Regulator of G protein signaling 6 mediates
doxorubicin-induced
myocardial
cell
apoptosis
and
cardiomyopathy. J. Yang, B. Maity, J. Huang, Z. Gao, A.
Stewart, R.M. Weiss, M.E. Anderson and R.A. Fisher. Univ.
of Iowa.
C323 1031.8 RGS6 deficiency promotes anxiolytic and
antidepressant behavior through potentiation of 5-HT1AR
signaling. A. Stewart, B. Maity, A.M. Wunsch, J.A. Wemmie
and R.A. Fisher. Univ. of Iowa.
341
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BIOCHEMISTRYTUESDAY
C324 1031.9 The conformation of active receptor-bound
arrestin. V. Gurevich, M. Kim, S.A. Vishnivetskiy, N. Van Eps,
N.S. Alexander, W.M. Cleghorn, X. Zhan, S.M. Hanson, T.
Morizumi, O.P. Ernst, J. Meiler and W.L. Hubbell. Vanderbilt
Univ., UCLA and Univ. of Toronto.
C325 1031.10 Protein structure in context: the landscape of
angiogenesis. E.A. Pellmann, D. Goodsell, R. Ramchandran,
M. Franzen, T. Herman and D. Sem. Concordia Univ.
Wisconsin, The Scripps Res. Inst., Med. Col. of Wisconsin and
Milwaukee Sch. of Engin.
C326 1031.11 A BRAF-MEK complex reveals the molecular
basis of oncogenic mutations. S.G. Hymowitz, J. Sudhamsu,
J. Haling, A. Peck, I. Yen, T. Morales, B. Brandhuber and S.
Malek. Genentech, South San Francisco and Array BioPharma,
Boulder.
C327 1031.12 Role of PLD and PA in alcohol (EtOH)-mediated
mTOR signaling in C2C12 myocytes. L.Q. Hong-Brown, C.R.
Brown, M. Navaratnarajah and C.H. Lang. Penn State Col. of
Med.
C328 1031.13 Control of entry into meiosis and quiescence in
budding yeast. S. Sarkar, J. Millar and P. Arumugam. Univ. of
Warwick, U.K.
C329 1031.14 Estrogen regulation of Jun and Fos in MCF7 cells. R. Geck, J.N. Magill and J.M. Schmitt. George Fox
Univ., OR.
C330 1031.15 AKAP7 regulates CaM kinase activation in
MCF-7 cells. H.M. McFarland, K. Dodge-Kafka and J.M.
Schmitt. George Fox Univ., OR and Univ. of Connecticut Hlth.
Ctr.
C331 1031.16 Arrestin-dependent activation of ERK1/2 in
response to follicle stimulating hormone. S. Chevalier and B.
Cohen. Union Col., NY.
C332 1031.17 miR-27b regulates expression of fibrotic genes
by targeting Gremlin 1. J.R. Graham, C. Williams and Z. Yang.
Pfizer Inc., Cambridge, MA.
C333 1031.18 Identification of regulatory factors of the
stationary phase sigma factor RpoS in Escherichia coli. K.
Nguyen and C. Peterson. Suffolk Univ., MA.
C334 1031.19 Analysis of novel interacting protein partners
of Wwsc1p and Mid2p, two sensor proteins of the PKC1
signaling pathway. E. Santiago, C. De Jesús, A. Borrero, N.M.
Caballero, O.J. Diaz, I. Stagljar and J.R. Rodríguez-Medina.
Univ. of Puerto Rico Med. Sci. Campus and Río Piedras
Campus, San Juan Bautista Sch. of Med., PR, Ederly Col. of
Sci., Penn State, Univ. of Puerto Rico Mayaguez Campus and
Univ. of Toronto.
C335 1031.20 Determinants of physical and functional
coupling between thromboxane A2 receptor and Gaq. R.
Chakraborty, B. Xu, R.P. Bhullar and P. Chelikani. Univ. of
Manitoba.
C336 1031.21 Tumor suppressor p53 status as a determinant
of estrogen receptor beta signaling in breast cancer. G.M. Das,
U.K. Mukhopadhyay, S. Bansal, R. Medisetty, W.M. Swetzig
and N. Wickramasekera. Roswell Park Cancer Inst.
C337 1031.22 Multiple solvent crystal structures of Rap1a
GTPase. P. Donohue and C. Mattos. Northeastern Univ.
C338 1031.23 V-ATPase is a novel evolutionarily conserved
cytohesin-signaling receptor. H. Hosokawa, P.V. Dip, M.
Merkulova, A. Bakulina, Z. Zhuang, A. Khatri, X. Jian, P.A.
Randazzo, D.A. Ausiello, G. Grüber and V. Marshansky.
Massachusetts Gen. Hos., Harvard Med. Sch., Nanyang Tech.
Univ., Singapore, State Res. Ctr. Virol. Biotech., Koltsovo,
Russia and NCI, NIH.
342
C339 1031.24 Identification of key signaling molecules
downstream of cAMP that regulate insulin secretion. J.C.
Neuman, N.A. Truchan, R.L. Pasker and M.E. Kimple. Univ.
of Wisconsin-Madison.
C340 1031.25 Novel signaling pathways triggered by a
human alpha1a-adrenoceptor genetic variant. A. Oganesian,
M. Kleine-Brueggeney, I. Gradinaru, E. Babaeva and D.A.
Schwinn. Univ. of Washington and Univ. of Iowa.
1032.APOPTOSIS AND CELL STRESS
Poster
Exhibit Halls A-B
C341 1032.1 The Bcl-2 family members Mcl-1 and Bim
modulate apoptosis in glutamine-deprived Sp2/0-Ag14 mouse
cells. E.R. Gauthier, C. Zhou, J. Woodley and C. Harnett.
Laurentian Univ., Canada.
1033.BIOCHEMICAL PHARMACOLOGY
Poster
Exhibit Halls A-B
C342 1033.1 An oxygen-chelate precious metal-based
complex, palladium bis-acetylacetonate, induces apoptosis
in lung cancer H460 cells via endoplasmic reticulum stress
pathway rather than interacting with DNA. Y. Wang, X. Li, H.
Zhou and G. Liang. Sch. of Pharm., Wenzhou Med. Col.,
China and Virginia Commonwealth Univ.
C343 1033.2 Apigenin and kaempferol inhibit LPS-induced
inflammatory responses by regulating intracellular translocation
of RNA-binding protein HuR in macrophages. X. Zhang, G.
Wang, R. Liu, L. Zhang, P.B. Hylemon, W.M. Pandak and H.
Zhou. Virginia Commonwealth Univ., China Pharmaceut. Univ.,
Nanjing and McGuire VA Med. Ctr.
C344 1033.3 Wagonin inhibits LPS-induced expression of
inflammatory cytokines by promoting mRNA degradation in
macrophages. X. Wan, Y. Huang, G. Liang, J. Xiao, X. Li, E.C.
Gurley and H. Zhou. Sch. of Pharm., Wenzhou Med. Col.,
China and Virginia Commonwealth Univ.
C345 1033.4 Spice synthetic cannabinoid drugs: lung and
adrenal cell models. O.A. Vanderpuye, T. Smith, B. Walker, M.
Gilbert and O. Okediji. Albany State Univ.
C346 1033.5 Production of transgenic mice expressing
human protein C. K-S. Min, T. Nanjidsuren, C-W. Park and
S-J. Yun. Hankyong Natl. Univ., South Korea.
C347 1033.6 Expression of 20[alpha] HSD in porcine ovary
and placenta during early pregnancy. K-S. Min, T. Nanjidsuren
and C-W. Park. Hankyong Natl. Univ., South Korea.
C348 1033.7 Mutation of non-essential cysteines leads to
highly soluble and active recombinant full-length NEMO. S.M.
Cote, M. Herscovitch, R. Prenovitz, T. Ennis, T.D. Gilmore
and A. Whitty. Boston Univ.
TUESDAYBIOCHEMISTRY
C349 1033.8 Characterization
of
simvastatin-induced
structural and functional alterations in the molecules of kidney
brush border membrane by ATR-FTIR spectroscopy and
chemometric approaches. F. Severcan, S. Uzun Gocmen, N.
Simsek Ozek and M. Severcan. Middle East Tech Univ. and
Mustafa Kemal Univ. Fac. of Med., Turkey.
C350 1033.9 Fertility activity of aqueous leaf extract of
Tapinanthus bangwensis on ovulation in female SpragueDawley rats. D. Onadeko, S.C. Nwoke, A.O. Magbagdeola,,
A.O. Ebuehi, N.O. Imaga, G.O. Ajayi, and S.C. Gbotolorun,.
Univ. of Lagos, Nigeria.
1034.CASPASES
Poster
Exhibit Halls A-B
C351 1034.1 Expression of a metacaspase from the fungus
Schizophyllum commune. E.B. Loew and K.M. Fox. Union
Col., NY.
C352 1034.2 Expression, extraction and activity testing of
the metacaspase Scp3. C. Gagliardi and K.M. Fox. Union
Col., NY.
1035.CELL PROLIFERATION
Poster
Exhibit Halls A-B
C353 1035.1 Identification and expression analysis of two
homologs from Xenopus laevis of the tumorhead putative
binding protein, FBXO30. J.M. Ayala-Figueroa, N. Flores, D.
Nuñez, T. Zbinden and E. Traverso. Univ. of Puerto Rico at
Humacao and Rio Piedras.
C354 1035.2 Functional characterization of novel tumor
suppressor protein Sav1 in cancer cell proliferation and
epithelial-mesenchymal transition. N. Sakai and K. Shibata.
Himeji Dokkyo Univ., Japan.
C355 1035.3 Identification of binding proteins of the Xenopus
morphogenetic factor, Tumorhead. K.M. Alicea-Torres, E.
Lopez, N. Flores, I.E. Vega and E.E. Traverso. Univ. of Puerto
Rico at Humacao and Univ. of Puerto Rico at Rio Piedras.
C356 1035.4 CTP synthase, a smooth muscle-sensitive
therapeutic target for effective vascular repair after injury. R.
Tang. Univ. of Georgia.
C357 1035.5 Retardation of cell proliferation by lowtemperature atmospheric plasma exposure on C2C12
myoblast. N. Nakai, F. Kawano and Y. Ohira. Osaka Univ.
1036.SIGNALING TO THE CYTOSKELETON
Poster
Exhibit Halls A-B
C358 1036.1 AKAP79 interacts with the axon guidance
receptor Robo2. B. Samelson, M. Colledge and J. Scott.
Univ. of Washington.
C359 1036.2 Two domains of the smoothelin-like 1 protein
bind apo- and calcium-calmodulin independently. A. UlkeLemee, H. Ishida, H.J. Vogel and J.A. MacDonald. Univ. of
Calgary, Canada.
C360 1036.3 Investigating the role of neuronal AKAP220
signaling complexes in cytoskeletal regulation during neurite
outgrowth. J.L. Whiting, B. Tunquist and J.D. Scott. Univ. of
Washington and Array BioPharma, Boulder.
C361 1036.4 A functional analysis of the projection
domain of the microtubule associated protein tau using force
spectroscopy. J. Saunders and Z. Donhauser. Vassar Col.
C362 1036.5 Identification of calregulin binding proteins in
a renal cell line. A.A. Alli, M.S. Ghant, D.S. Montgomery and
D.C. Eaton. Emory Univ. and Clark Atlanta Univ.
C363 1036.6 Anillin regulates cell-cell junction integrity in
the intact epithelium via RhoA and F-actin. A.L. Miller, C.C.
Reyes, M. Jin, R. Espino, E. Breznau and A. Goryachev.
Univ. of Michigan and Sch. of Biol. Sci., Univ. of Edinburgh.
1037.TOXINS
Poster
Exhibit Halls A-B
C364 1037.1 Mechanism of non point source(s) causing
antibiotic-resistance in infectious diseases. S. Kannan, J.
Martinez, H. Montoya, J. Barrera, R. Cooley, M. Orozco and
B. Villanueva. Southwest Texas Junior Col., Fort Duncan Reg.
Med. Ctr., Waste Water Recycling Plant, City of Eagle Pass
Water Works, CEPWW, Maverick County Water Control and
Improvement District #1, Eagle Pass, TX.
C365 1037.2 Detection of aniline resistant and streptomycin
sensitive yeast R11 in processed biosolid. S. Kannan,
H. Montoya, J. Barrera, E. Longoria and A. Castillion.
Southwest Texas Junior Col., City of Eagle Pass Waste Water
Processing Plant and Eagle Pass Reg. Water Treatment Plant.
1038.PROTEIN PHOSPHORYLATION AND
DEPHOSPHORYLATION
Poster
Exhibit Halls A-B
C366 1038.1 Hepatocyte nuclear factor-4 phosphorylation
mediated by inflammatory response. Z. Wang, E. Salih and
P.A. Burke. Boston Univ. Sch. of Med. and Henry M. Goldman
Sch. of Dent. Med.
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BIOCHEMISTRYTUESDAY
C367 1038.2 Discovery of a bis-phosphokinetic motif in a
regulatory region of the transcription factor, BCL11B. T.M. Filtz,
W.K. Vogel, P.R. Gafken and M. Leid. Oregon State Univ. and
Fred Hutchinson Cancer Res. Ctr.
C368 1038.3 Phosphorylation-dependent interaction of
PRIP with Akt. G. Sugiyama, K. Nagano, T. Otani, J. Gao, H.
Takeuchi and M. Hirata. Fac. of Dent. Sci., Kyushu Univ. and
Kyushu Dent. Col., Japan.
C369 1038.4 Pasteurella multocida toxin activates mTOR
and inhibits PP2A via Gaq/11/PLCb/PKC. H. Oubrahim, Y. Shi
and P.B. Chock. NHLBI, NIH.
C370 1038.5 Two unique phosphorylation-driven signaling
pathways crosstalk in Staphylococcus aureus: STK1 meets
GraR. M. Fridman and D. Golemi-Kotra. York Univ., Canada.
C371 1038.6 Analysis of neuronal migration defects in src-1
mutant and Fyn transgenic C. elegans. K.L. Hinkle, Z. Fulton,
E. Chapdelaine and B. Ballif. Norwich Univ., VT and Univ. of
Vermont.
C372 1038.7 Protein tyrosine phosphatase 1B antagonized
Brk-mediated IGF-1R signaling in ovarian cancer. G. Fan, C.
Fu, G. Lin, D. Pappin, R. Lucito and N.K. Tonks. Cold Spring
Harbor Lab., NY.
C373 1038.8 Phosphorylation of tau-4R and microtubule
binding region of MAP-2C by PKA and GSK-3b inhibits their
O-glycosylation by OGT. B.S. Khatra, M. Juarez, D. Johnson
and M. DeTure. California State Univ., Long Beach and Mayo
Clin., Jacksonville, FL.
C374 1038.9 Phosphorylation of the eukaryotic cortactin
protein by endogenous kinases in an E. coli expression system.
J. Priester, H. Love and A. Kruchten. Linfield Col., OR.
1039.ADAPTER PROTEINS
Poster
Exhibit Halls A-B
C375 1039.1 Cypher/ZASP, a PKA scaffolding protein to
regulate the phosphorylation of L-type calcium channel. H.
Cheng, C. Lin, X. Yin, X. Guo, J. Chen and Y. Ke. First Affil.
Hosp., Zhejiang Univ. Sch. of Med., China and UCSD Sch. of
Med.
C376 1039.2 Dissecting distinctive roles of GAB scaffolding
proteins in allergic inflammation in vivo. Y. Zhang, X. Zhang,
J. Xu, B. Tao, Z. Liang, H. Cheng and Y. Ke. Zhejiang Univ.,
China.
C377 1039.3 Identifying
chemotaxis
protein-protein
interactions in Epulopiscium sp. type B using a yeast two hybrid
system. B. Levesque and A.J. Piefer. Hartwick Col., NY.
C378 1039.4 Chemotaxis in Epulopiscium. P. Faughnan
and A. Piefer. Hartwick Col., NY.
1040.G PROTEINS AND PROTEIN KINASES
Poster
Exhibit Halls A-B
C379 1040.1 Role of the GRK2 extreme amino terminus and
active site tether in forming G protein-coupled receptor docking
site. R. Sterne-Marr, K. Michalski, A. Beautrait, T. Lopez, K.
Mannix, D. McDonald, A. Cutter, C. Francis, C. Medina, M.
Bouvier and J. Tesmer. Siena Col., NY, Univ. of Montreal and
Univ. of Michigan.
C380 1040.2 S1P1 receptor regulation by phosphorylation.
S. Bazúa-Valenti, M.A. Morquecho-León, M.T. RomeroÁvila and J.A. García-Sáinz. UNAM, Mexico City.
C381 1040.3 Lysophosphatidic acid-stimulated p130Cas
phosphorylation and invasive migration of ovarian cancer cells
involves a Gai2-dependent signaling mechanism. J. Ward and
D. Dhanasekaran. Univ. of Oklahoma Hlth. Sci. Ctr.
C382 1040.4 Structures of the G-beta–CCT and PhLP1–Gbeta–CCT complexes reveal a molecular mechanism for G
protein beta subunit folding and beta-gamma dimer assembly.
R. Plimpton, J. Cuellar, C.W.J. Lai, R. Taylor, J.L. Carrascosa,
J.T. Prince, J. Valpuesta and B.M. Willardson. Brigham Young
Univ. and Natl. Biotechnol. Ctr., Madrid.
1041.KINASE CASCADES
Poster
Exhibit Halls A-B
C383 1041.1 Quantitative analysis of how RET receptor
activation is coupled to ERK and Akt signaling. S. Li, J.
Noorbakhsh, T.V. Riera, P. Mehta and A. Whitty. Boston Univ.
C384 1041.2 Beta synemin binds PKA type I upon betaadrenergic stimulation in HL-1 cells. B.C. Prudner, D.S.
Damron and M.A. Russell. Kent State Univ. and Kent State
Univ. Trumbull.
C385 1041.3 Control of plasma membrane lipid asymetry at
the bud neck: septin-bound protein kinase Gin4 locally controls
flippase function. F.M. Roelants, B. Su, J. von Wulffen and J.
Thorner. Univ. of California, Berkeley.
C386 1041.4 Characterization of BI-D1870, the ATPcompetitive small molecule inhibitor of p90 ribosomal S6
kinase. L.S. Jones. Univ. of North Carolina at Chapel Hill.
1042.MAP KINASES
Poster
Exhibit Halls A-B
C387 1042.1 Investigating inactive conformations of protein
kinases. S.B. Hari, B.G.K. Perera, S.E. Leonard and D.J.
Maly. Univ. of Washington.
344
TUESDAYBIOCHEMISTRY
C388 1042.2 Epitope guided engineering of monobody
binders for in vivo inhibition of Erk-2 signaling. S. Park, J.K.
Mann, J.F. Wood, A.F. Stephan, E.S. Tzanakakis and D.M.
Ferkey. Univ. at Buffalo, SUNY.
C389 1042.3 Characterization of a microtubule-associated
protein, doublecortin (DCX), as a substrate of c-Jun N-terminal
kinases. K. Ngoei, P.R. Gooley, M.W. Parker and M.A.
Bogoyevitch. Univ. of Melbourne and St. Vincent’s Inst. of
Med. Res., Fitzroy, Australia.
C390 1042.4 JNK3 binding to arrestin-3 differentially affects
recruitment of upstream MAP kinase kinases. X. Zhan, T.S.
Kaoud, S. Kook, K.N. Dalby and V.V. Gurevich. Vanderbilt
Univ. and Univ. of Texas at Austin.
C391 1042.5 The effect of TBBPA on MAP3Ks in human
natural killer cells. L.J. Celada and M.M. Whalen. Tennessee
State Univ.
C392 1042.6 Arrestin-3 binding to JNK1alpha1/JNK2alpha2:
modulation of JNK1 and JNK2 activity via scaffolding. S.
Kook, X. Zhan, T.S. Kaoud, K.N. Dalby, V.V. Gurevich and
E.V. Gurevich. Vanderbilt Univ. Med. Ctr. and Univ. of Texas at
Austin.
C393 1042.7 Overcoming drug-induced resistance in BRaf
mutated melanoma cells. R. Samadani, K-Y. Jung, J. Zhang,
A. MacKerell, S. Fletcher and P. Shapiro. Univ. of Maryland
Baltimore.
1043.PHOSPHATASES
Poster
Exhibit Halls A-B
C394 1043.1 Molecular basis for a bipartite phosphatase
interaction with the anchoring protein AKAP79. P.J. Nygren,
M.G. Gold, C.R. Weisbrod, J.E. Bruce and J.D. Scott. Univ. of
Washington and University Col. London.
C395 1043.2 Structural mechanism of trimeric PR70 PP2A
holoenzyme: insights into Cdc6 dephosphorylation. N.J.
Wlodarchak, F. Guo, K.A. Satyshur, L. Jiang, P.D. Jeffrey,
T. Sun, V. Stanevich, M.C. Mumby and Y. Xing. Univ. of
Wisconsin-Madison, Princeton Univ. and Univ. of Texas
Southwestern Med. Ctr.
C396 1043.3 Structural basis of PP2A phosphatase activator
reveals a unique chaperone function in PP2A activation. F. Guo,
V. Stanevich, N. Wlodarchak, Y. Li, D.C. Pallas, R. Sengupta,
L. Jiang, K.A. Satyshur and Y. Xing. Uof Wisconsin-Madison,
Sch. of Med. and Publ. Hlth. and Emory Univ. Sch. of Med.
C397 1043.4 Regulation
of
epithelial-mesenchymal
transition and apoptosis by dual specificity phosphatase-2.
S-C. Lin, K-Y. Hsiao and S-J. Tsai. Natl. Cheng Kung Univ.,
Taiwan.
C398 1043.5 Structural basis of stable PP2A latency by a4protein. V. Stanevich, L. Jiang, R. Sengupta, K. Satyshur,
G. Watkins, B. Wadzinski, M. Kong and Y. Xing. Univ. of
Wisconsin-Madison, Vanderbilt Univ. Med. Ctr. and City of
Hope Natl. Med. Ctr., Duarte, CA.
C399 1043.6 Structural insights into tight control of PP2Aa
methylation and function by LCMT-1. V. Stanevich, L. Jiang, K.
Satyshur, Y. Li, P. Jeffrey, Z. Li, P. Menden, M. Semmelhack
and Y. Xing. Univ. of Wisconsin-Madison and Princeton Univ.
1044.RECEPTOR TYROSINE KINASE SIGNALING TO
NUCLEUS
Poster
Exhibit Halls A-B
C400 1044.1 Meta-analysis of nuclear targets of tyrosine
phosphorylation: identifying nodes that regulate nuclear activity.
P.V. Hornbeck, J. Kornhauser, E. Skrzypek, B. Zhang, V.
Latham and B. Murray. Cell Signaling Technol., Danvers, MA.
C401 1044.2 Src kinase mediates renal interstitial fibroblast
activation and proliferation. L. Ma, J. Tang, M. Ponnusamy and
S. Zhuang. Brown Univ.-Rhode Island Hosp.
1045.SERINE/THREONINE KINASE
Poster
Exhibit Halls A-B
C402 1045.1 Protein kinase C mutations in cancer. C.E.
Antal, E. Kang and A.C. Newton. UCSD.
C403 1045.2 Structural insights into the VRK1-mediated
histone phosphorylation and its regulation by mH2A1, a histone
H2A variant. H.S. Yoon, J. Shin and G. Chakraborty. Sch. of
Biol. Sci., Nanyang Technol. Univ., Singapore.
C404 1045.3 Using ProPeL to discover the binding specificity
of human DYRK1a. J. Lubner, M.F. Chou, G.M. Church and D.
Schwartz. Univ. of Connecticut and Harvard Med. Sch.
C405 1045.4 RhoA kinase phosphorylation of NHE1 impact
on growth factor and G protein coupled receptor signaling. N.
Berthelsen, H. Pantera, J. Sauer, J. Lawrence, M. Wallert
and J. Provost. Minnesota State Univ. Moorhead and Univ. of
Wisconsin-Stevens Point.
C406 1045.5 Structure of the eukaryotic atypical RIO
kinases reveals ATPase-dependent mechanism in ribosome
biogenesis. N.A. LaRonde. Univ. of Maryland College Park.
C407 1045.6 Investigations into the role of lantibiotic
cyclase-like proteins in mammals. M. Zeng, J. Chen and W.
van der Donk. Univ. of Illinois at Urbana-Champaign.
1046.SMALL GTPASES
Poster
Exhibit Halls A-B
C408 1046.1 Role of DLC1 in regulating cellular and focal
adhesion dynamics. S. Kaushik and B.C. Low. Natl. Univ. of
Singapore and Mechanobiol. Inst., Singapore.
C409 1046.2 The identification, characterization, and
subcellular localization of a novel potential GTPase activating
protein involved in cytokinesis. S.L. Faitar, J.J. Kilijanski, K.W.
Heassler and J.J. Davie. D’Youville Col., NY.
345
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BIOCHEMISTRYTUESDAY
C410 1046.3 Ras activity regulation by monoubiquitination.
S.L. Campbell, R. Baker, S. Lewis, A. Sasaki, E.M. Wilkerson,
J. Locasale, L.C. Cantley, B. Kuhlman and H. Dohlman. Univ.
of North Carolina at Chapel Hill and Harvard Med. Sch.
C411 1046.4 PDZ-RhoGEF and LARG are essential for
embryo development, and provide a link between thrombin
receptors and Rho activation. C.M. Mikelis, M. Simaan, W.
Li, R. Szabo, D. Martin, Y. Mukouyama, T.H. Bugge and S.J.
Gutkind. NIDCR and NHLBI, NIH.
C412 1046.5 Contribution of residue 188 identity to RhoA
and RhoC membrane association. N. Peyton, A. Reicks, A.
Patel and S. Ellerbroek. Wartburg Col., IA.
C413 1046.6 Over-expression of mutant Rheb proteins and
mTOR signaling. D. Teran and N. Parmar. California State
Univ. Channel Islands.
C414 1046.7 Rac1b, a variant of Rac1 interacts with
calmodulin. N. Khanna, B. Xu, P. Chelikani and R.P. Bhullar.
Univ. of Manitoba.
1049.CYCLASES
Poster
Exhibit Halls A-B
C421 1049.1 Nasal mucus contains cAMP and cGMP which
are critical factors in preservation of normal olfaction. R.I.
Henkin. The Taste and Smell Clin., Washington, DC.
C422 1049.2 ATP inhibition couples guanylyl cyclase A and
B to cellular energy status. L.R. Potter, M.A. Mauseth and
J.W. Robinson. Univ. of Minnesota, Minneapolis.
1050.INOSITOL PHOSPHATES AND
PHOSPHOINOSITIDES
Poster
1047.CALCIUM
Poster
Exhibit Halls A-B
C415 1047.1 LT1002 metalloantibody uses Ca2+ cofactor.
A.D. Ward, D. Yacoub, F. Erasmus and T. Huxford. San Diego
State Univ.
C416 1047.2 Automated analysis of Ca2+ mobilization in the
cornea under hypoxia. A. Lee, K. Derricks and V. TrinkausRandall. Boston Univ. Sch. of Med.
C417 1047.3 Calcium-induced structural changes of the
CaM–KCNQ complex. A. Lvov, K. Mruk and W.R. Kobertz.
Univ. of Massachusetts Med. Sch. and Stanford Univ. Sch. of
Med.
C418 1047.4 Endothelial cell-specific STIM1 deletion
prevents lung vascular leak. A. DebRoy, S.M. Vogel, P.C.
Sundivakkam, Y-Y. Zhao, A.B. Malik and C. Tiruppathi. Univ.
of Illinois at Chicago.
C419 1047.5 A role for the excess ryanodine receptors in
excitation-contraction coupling. S. Pitake and R.S. Ochs. St.
John’s Univ., NY.
1048.GTPASES
Poster
Exhibit Halls A-B
C420 1048.1 Human and murine Evc proteins contain
functional P-loops and possess intrinsic GTPase activity. O.O.
Odunuga. Stephen F. Austin State Univ., TX.
346
Exhibit Halls A-B
C423 1050.1 Tertiary conformational transition in horse
haemoglobin induced by inositol hexakisphosphate. O.E.
Omotosho, K.O. Okonjo, V.T. Omotosho, S.O. Rotimi and
S.N. Chinedu. Covenant Univ., Nigeria.
C424 1050.2 The
effect
of
phosphatidylinositol
4,5-bisphosphate depletion on the internalization of G proteincoupled receptors. D.J. Tóth, J.T. Tóth, B. Tallósy, L. Hunyady
and P. Várnai. Fac. of Med., Semmelweis Univ. and Hungarian
Acad. of Sci., Budapest.
C425 1050.3 The kinetic properties of a human PPIP5K
reveal that its kinase activities are protected against the
consequences of a deteriorating cellular bioenergetic
environment. J.D. Weaver, H. Wang and S.B. Shears. NIEHS,
NIH, Research Triangle Park.
1051.NITRIC OXIDE
Poster
Exhibit Halls A-B
C426 1051.1 Endomembrane HRas controls the PI3 kinase/
Akt/eNOSsignaling cascade in VEGF induced endothelial
cell migration. D. Haeussler, J.R. Burgoyne, X. Hou, D.R.
Pimental, R.A. Cohen and M.M. Bachschmid. Boston Univ.
Sch. of Med. and King’s Col. London.
C427 1051.2 A muscle-specific isoform of neuronal nitric
oxide synthase is phosphorylated in response to insulin. K.
Hinchee-Rodriguez, N. Garg, P. Venkatakrishnan, M.G.
Roman, M. Adamo, B.S. Masters and L.J. Roman. Univ. of
Texas Hlth. Sci. Ctr. at San Antonio.
C428 1051.3 Protein phosphatase 2A B56a mediates
retinoic acid-induced decreases in phosphorylation of
endothelial nitric oxide synthase at serine 1179 and nitric oxide
production. I. Jo, J-H. Park, H.Y. Sung, J.Y. Lee, H.J. Kim and
J-H. Ahn. Ewha Womans Univ. Med. Sch., South Korea.
TUESDAYBIOCHEMISTRY/NUTRITION
1052.PHOSPHODIESTERASES
Poster
Exhibit Halls A-B
C429 1052.1 Heterologous
expression
of
human
phosphodiesterase 3A enhances oxidative stress resistance in
yeast. D.K. Rhee, J.C. Lim, S.C. Hockman, F. Ahmad and V.C.
Manganiello. NHLBI, NIH.
C430 1052.2 Regulation of photoreceptor phosphodiesterase
(PDE6) by the rod photoreceptor-specific glutamic acid-rich
protein 2. W. Yao and R.H. Cote. Univ. of New Hampshire.
C431 1052.3 Selective regulation of PDE3A isoforms by
differential phosphorylation. F. Vandeput, N. Szabo-Fresnais,
A. Dunlop, J. Krall, V.C. Manganiello, M.D. Houslay and M.A.
Movsesian. VA Salt Lake City Hlth. Care Syst., Univ. of Utah,
Univ. of Glasgow, U.K., NHLBI, NIH and King’s Col. London.
C432 1052.4 Proteomic
identification
of
preferential
interactions between PDE6 and its inhibitory subunit. K.A.
Kozacka, X-J. Zhang, X-Z. Gao, X. Zeng, F. Chu and R.H.
Cote. Univ. of New Hampshire.
C433 1052.5 Probing the structure of photoreceptor
phosphodiesterase (PDE6) and its interactions with transducin
by cross-linking and molecular modeling. X-Z. Gao, X. Zeng,
X-J. Zhang, F. Chu and R.H. Cote. Univ. of New Hampshire.
C434 1052.6 PDE inhibitors as potential pesticides targeting
parasitic nematodes. K.D. Schuster, K.B. Cahill, K. Morris,
W.K. Thomas and R.H. Cote. Univ. of New Hampshire.
Nutrition
1053.NUTRITION, PHYSICAL PERFORMANCE AND
BONE HEALTH
Poster
(Sponsored by: Aging and Chronic Disease RIS)
Exhibit Halls A-B
Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II)
D1
I1053.1Effects
of
short-term
protein
supplementation on muscle work efficiency in elderly adults.
K.A. Sands, K.L. Clark, S.P. McKenzie, J.M. Haddad, S.
Rietdyk and W.W. Campbell. Purdue Univ. and Indiana Univ.Purdue Univ. Indianapolis.
D2
II1053.2Dairy foods intake and bone health.
N.A.G. de França, B.S.E. Peters, W.N. de Souza, M.R.
Camargo, M. Lazaretti-Castro and L.A. Martini. São Paulo
Univ., Brazil and Fed. Univ. of São Paulo.
D3
I1053.3Genistein
activates
BMP-Smad
signaling pathway in MC3T3-E1 cells. H. Katsuyama, S.
Fushimi, K. Yamane, H. Hinenoya, Y. Akiyama, M. Tomita,
T. Okuyama, Y. Watanabe, M. Katsuyama and K. Saijoh.
Kawasaki Med. Sch. and Kanazawa Univ. Sch. of Med., Japan.
D4
II1053.4Cortical femur response to synbiotics
in aging mice. C. Blanton, M. Tyler and A. Gabaldon. Idaho
State Univ. and Colorado State Univ.-Pueblo.
D5
I1053.5Estrogen deficiency worsened Ca
balance via downregulation of epithelial Ca transport proteins
in aged female rats. M.S. Wong, X. Dong and Y. Zhang. The
Hong Kong Polytech Univ.
D6
II1053.6New formulation with potential for the
prevention and treatment of osteoporosis and osteoarthritis.
A. Torrent, E. Montell, J. Vergés, R. Ruhí, P. Dalmau, M.C.
Carceller, A. Blanco, M.C. Terencio, M.L. Ferrándiz and M.J.
Alcaraz. Bioiberica, S.A. and Univ. of Valencia, Spain.
D7
I1053.7Bone turnover markers detect different
treatment effects within six weeks. E.R. Gertz, T. Rogers, E.
Demmer, D. Cheng, A. Villegas, M. Garrod and M. Van Loan.
USDA, Davis, Univ. of California, Davis, Univ. of California,
Berkeley and Univ. of California Merced.
D8
II1053.8Effect of saturated or monounsaturated
fatty acids on bone and calcium absorption in older mice. Y.
Wang, P. Dellatore, K. Patel, R. Ferraris and S. Shapses.
Rutgers Univ. and UMDNJ-New Jersey Med. Sch.
D9
I1053.9The
efficacy
of
tart
cherry
supplementation in the prevention of age-related bone loss in
C57BL6 mice. P. Chongwatpol, E. Rendina, J.L. Graef, S.L.
Clarke, E.A. Lucas and B.J. Smith. Oklahoma State Univ.
D10 II1053.10Novel anti-osteoclastogenic activity of
fisetin antagonizing RANKL-induced bone resorption in murine
macrophages. Y. Kim, J-L. Kim and Y-H. Kang. Hallym Univ.,
South Korea.
D11 I1053.11
Osteogenic activity of milk thistle extract
after ovariecotmy to dampen estrogen deficiency-induced
osteoporosis. J-L. Kim, Y. Kim, E. Lee and Y-H. Kang. Hallym
Univ., South Korea.
D12 II1053.12Dietary intake of purple sweet potato
powder affected bone mineral content of ovariectomized rats.
C. Wang, L. Huang, X. Zheng and C. Butler. Kentucky State
Univ. and Northwest A&F Univ., China.
D13 I1053.13
High blood pressure and arterial
stiffness are not associated with low bone mass. S.A. Johnson,
A. Figueroa, N. Navaei, A. Wong, R. Kalfon, M. Elam, M.
Payton and B.H. Arjmandi. Florida State Univ. and Oklahoma
State Univ.
D14 II1053.14Association between serum levels of
vitamin D with body fat mass, fasting glucose and lipid profile
in patients with osteogenesis imperfecta. B.S.E. Peters, M.
Lazaretti-Castro, L.F. Hayashi, A.V. Costa and L.A. Martini.
São Paulo Fed. Univ. and Univ. of São Paulo.
D15 I1053.15
The relationship between sex hormones
and osteoarthritis. R.G. Feresin, M.L. Elam, Y. Zhao, S.
Hooshmand and B.H. Arjmandi. Florida State Univ. and San
Diego State Univ. Sch. of Exer. and Nutr. Sci.
D16 II1053.16Use of calcium isotope tracers for
screening potential treatments for osteoporosis. E.E. Hohman,
B.R. Martin, L.D. McCabe, G.P. McCabe, G.S. Jackson, M.
Peacock and C.M. Weaver. Purdue Univ. and Indiana Univ.
Sch. of Med.
347
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NUTRITIONTUESDAY
1054.FOOD SECURITY AND ITS CONNECTIONS TO
NUTRITION AND HEALTH
Poster
(Sponsored by: Community and Public Health RIS)
Exhibit Halls A-B
D17 I1054.1Influence of leadership on the systematic
identification of child food insecurity in schools. E.M. Fishbein,
M.S. Fram and E.A. Frongillo. Univ. of South Carolina.
D18 II1054.2Development of a two-item quick screen
for household food insecurity assessment. M. Na, K. West, A.A.
Shamim, S. Mehra, A. Labrique, H. Ali, L. Wu, R. Klemm and
P. Christian. Johns Hopkins Bloomberg Sch. of Publ. Hlth. and
JiVitA Proj., Bangladesh.
D19 I1054.3Food insecurity in Palestinian and Iraqi
refugees in Lebanon. H. Ghattas, N.R. Sahyoun, K. Seyfert
and A.J. Sassine. American Univ. of Beirut, Univ. of Maryland
College Park and Sch. of Oriental and African Studies, London.
D20 II1054.4Iron deficiency and anemia are not
associated with food insecurity in pregnant women in the
United States: NHANES 1999-2008. C. Park and H.A. EicherMiller. Purdue Univ.
D21 I1054.5Food insecurity is not associated with
body mass index among low-income African American adult
residents in Baltimore City. N. Budd, D. Liu, A. Cuccia, B.
Jock, J. Jeffries, K. Frick and J. Gittelsohn. Johns Hopkins
Bloomberg Sch. of Publ. Hlth. and Univ. of North Carolina
Gillings Sch. of Global Publ. Hlth.
D22 II1054.6Very low food security among children
is associated with daily energy intake and diet quality. M.P.
Burke, S.J. Jones, C.E. Blake, M.S. Fram and E.A. Frongillo.
Univ. of South Carolina.
D23 I1054.7Functional limitation and chronic
diseases are associated with food insecurity among U.S.
adults. B.J. Venci, S. Park and S-Y. Lee. Univ. of Cincinnati
and Ctrs. for Dis. Control and Prevent.
D24 II1054.8Are physical activity and food insecurity
associated with depressive feelings in U.S. adults? M. McNeill,
B.J. Venci, S. Park and S-Y. Lee. Univ. of Cincinnati and Ctrs.
for Dis. Control and Prevent.
D25 I1054.9Food insecurity and food patterns in
Mexican-heritage children. A. Aguilera and L. Kaiser. Univ. of
California, Davis.
D26 II1054.10The distribution of food insecurity in
Mexico. T. Shamah Levy, V. Mundo-Rosas, L. Cuevas-Nasú,
M.C. Morales-Ruan and J.A. Rivera Dommarco. Natl. Publ.
Hlth. Inst., Cuernavaca.
D27 I1054.11
The effects of short-term participation
in the Supplemental Nutrition Assistance Program on food
security and dietary intake of low-income Massachusetts
adults: a pilot study. C.W. Leung, S. Cluggish, E. Villamor, P.J.
Catalano, W.C. Willett and E.B. Rimm. UCSF, Proj. BreadThe Walk for Hunger, East Boston, Univ. of Michigan Sch. of
Publ. Hlth., Harvard Sch. of Publ. Hlth. and Dana Farber Cancer
Inst.
D28 II1054.12Food security and supplemental nutrition
assistance participation associated with home availability and
preschool child consumption of 100% fruit juice. K. Yarbrough,
E.A. Schilling and A.M. Ferris. Univ. of Connecticut Hlth. Ctr.,
East Hartford.
348
D29 I1054.13
Effect of prenatal and postpartum
food security status on breastfeeding initiation and duration
in Massachusetts WIC participants 2001-2009. L.S. Brown,
R. Colchamiro, S. Edelstein and E. Metallinos-Katsaras.
Simmons Col. and Massachusetts Dept. of Publ. Hlth., Boston.
D30 II1054.14Higher health services utilization and
lower antiretroviral treatment-adherence in food insecure
HIV-infected adults in Miami, FL. M. Farsad, A. Campa,
S.S. Martinez, Y. Li, S. Williams, S. Barr, T. Stewart, V.
Ramamoorthy, P. Greer, D. Gracia and M.K. Baum. R.
Stempel Col. of Publ. Hlth. and Soc. Work and Col. of Med.,
Florida Intl. Univ. and Borinquen Hlth. Care Ctr., Miami.
D31 I1054.15
Healthy Eating Index in drug users
living in three U.S. East Coast cities. A. Tang, K. Hendricks, S.
Skinner, K. Dong, H. Sheehan and C. Wanke. Tufts Univ. Sch.
of Med. and Dartmouth Univ. Geisel Sch. of Med.
D32 II1054.16Household food insecurity and dietary
intake among Hispanic women of childbearing age. A. Hilmers,
T-A. Chen, D.C. Hilmers and K.C. Cullen. Johns Hopkins
Bloomberg Sch. of Publ. Hlth. and Baylor Col. of Med.
D33 I1054.17
Persistent food insecurity is associated
with active coping strategies among low-income pregnant
Latinas. A. Hromi-Fiedler, A. Bermúdez-Millán, J. Leon,
S. Segura-Pérez and R. Pérez-Escamilla. Yale Univ., Univ.
of Connecticut Hlth. Ctr., Frank J. DiLoreto Dual Language
Magnet Sch., New Britain and Hispanic Hlth. Council, Hartford.
D34 II1054.18Household food insecurity is positively
associated with perceived discrimination among Cambodian
pregnant women in Massachusetts. S. Chen, J.N. Peterman,
R. Mouth and L. Cordeiro. Univ. of Massachusetts Amherst
and Cambodian Mutual Assist. Assn., Lowell, MA.
1055.GLOBAL NUTRITION: OBESITY AND
NUTRITION TRANSITION
Poster
(Sponsored by: Global Nutrition Council (GNC))
Exhibit Halls A-B
D35 I1055.1Overweight and obesity in children of
Arandas, Mexico during the nutrition transition. E.M. VasquezGaribay, L. Miranda Rios, E. Romero Velarde, M.E. Nuño
Cosio, R. Troyo Sanroman, L. Campos Barrera, E. Caro
Sabido, J. Ramirez Diaz and M.Tremblay. Univ. of Guadalajara
and Inst. Alteño para el Desarrollo de Jalisco, Mexico and Univ.
of Ottawa.
D36 II1055.2Effectiveness of “”Pilas””, a communitybased pilot intervention for chronic disease prevention in
Guatemalan school-age children. A.V. Chacon, P. Letona,
M. Ramirez-Zea, J. Gittelsohn and B. Caballero. INCAP,
Guatemala City and Johns Hopkins Bloomberg Sch. of Publ.
Hlth.
D37 I1055.3Mean total cholesterol/HDL-cholesterol
ratio and hs-CRP levels among foreign-born Afro Caribbeans
and their United States-born counterparts in South Florida. E.
Davis, F. Huffman and J. Dehpahlavan. Life Univ., GA and
Florida Intl. Univ. Stempel Sch. of Publ. Hlth.
TUESDAYNUTRITION
D38 II1055.4Cultural definitions of healthy eating:
views from poor Salvadorian communities. M. Fuster, E.
Messer, R.F. Houser, P. Palma, H. Deman and O.I. Bermudez.
Friedman Sch. of Nutr., Tufts Univ. , PRESANCA, San Salvador
and Tufts Univ. Sch. of Med.
D39 I1055.5Diet and other health-related behaviors
of individuals with impaired glucose tolerance, cardiovascular
disease (CVD) or CVD risk: a global view from the NAVIGATOR
study. C. Bales , S. Haffner, L. Thomas, J. Sun, T. Yates, K.
Huffman, R. Califf, J. Toumilehto, J. McMurray, R. Holman,
M. Davies and W. Kraus. VA Med. Ctr. and DCRI, Durham,
NC, Univ. of Texas Hlth. Ctr., Shavano Park, Univ. of Leicester,
Danube Univ., Austria, Univ. of Glasgow and Univ. of Oxford.
D40 II1055.6A case study: nutrition and physical
activity environments of public childcare centers in Korea,
Sweden, and U.S. J. Kim, N. Jackson, L.S. Elinder, D.
Singhru, L. Olsson, S. Bremberg and K. Kim. East Carolina
Univ., Karolinska Inst. and Sungkyunkwan Univ., South Korea.
D41 I1055.7Understanding the formulation process
of the Mexico and Spain school-feeding policies. K.Y. García ,
E.A. Frongillo, A.C. Dresser, E. Orozco and G. Rodríguez.
Natl. Inst. of Publ. Hlth., Morelos, Mexico and Univ. of South
Carolina.
D42 II1055.8A
cardiovascular
risk
reduction
intervention in patients with hypertension and/or type 2 diabetes
in San José, Costa Rica and Chiapas, México. H. Martinez,
M. Fort, A.L. Dengo, M. Castro, L. Peña, N. Alvarado, I. de
Beausset, M. Ramírez-Zea and S. Murillo. RAND Corp.,
Children’s Hosp. of Mexico “”Dr. Federico Gómez””, INCAP,
Guatemala City, Univ. of Costa Rica Sch. of Nutr. and UNICACH,
Tuxtla Gutiérrez, Mexico.
D43 I1055.9Maternal DHA supplementation during
pregnancy and plasma lipids and glucose levels in offspring
at age 4y: follow-up of a randomized controlled trial. Y.Y.
Gutierrez-Gomez, U. Ramakrishnan, A.D. Stein, R. Martorell,
C. Aguilar-Salinas, I. Romieu and J.A. Rivera. Natl. Inst. of
Publ. Hlth., Cuernavaca, Technol. of Monterrey, Mexico City,
Emory Univ., Natl. Nutr. Inst. Salvador Zubiran, Mexico City and
Intl. Agency for Res. on Cancer, Lyon.
D44 II1055.10Physiological changes in Japanese
students during a one-year study abroad program in the United
States. C.R. Cahill and S. Stavrianeas. Willamette Univ., OR.
D45 I1055.11
Associations between nutritional status
of micronutrients and the growth, body composition and
biomarkers of metabolic risk in Chilean children. D. Lopez de
Romana, C. Corvalan, R. Uauy, G. Cediel, G. Duran and A.M.
Palomino. Univ. of Chile.
D46 II1055.12Spatial characteristics of BMI among
women in Kurdistan, Iraq. K.M. Curtin, L. Pawloski, T.K.
Rasheed and H. Ahmad. George Mason Univ. and Univ. of
Salahhadin, Iraq.
D47 I1055.13
Who is undernourished and who is
overweight in Nigeria? O. Adeyemi, R.J. Stoltzfus, C.M.
Devine, D.L. Pelletier and P. Pinstrup-Andersen. Cornell
Univ.
D48 II1055.14Why have NCDs received so little
attention in Nigeria? O. Adeyemi, D.L. Pelletier, C.M. Devine,
P. Pinstrup-Andersen and R.J. Stoltzfus. Cornell Univ.
D49 I1055.15
The components of metabolic syndrome
in relation to weight status in South Indians. A. Must, M.
Thanikachalam, M. Begum, H. Vijayakumar, K. Chui, V.
Chomitz, O. Bermudez and S. Thanikachalam. Tufts Univ.,
Boston, The Ohio State Univ. and Sri Ramachandra Univ.,
India.
D50 II1055.16Animal and plant protein intakes among
different regional diets and their association with overweight
and obesity. F. Zhai, H. Wang, B. Zhang and S. Du. Inst. of
Nutr. and Food Safety, Chinese Ctr. for Dis. Control, Beijing and
Univ. of North Carolina at Chapel Hill.
D51 I1055.17
Associations between wealth and
weight status in Filipinos from birth to early adulthood. E.
Tzioumis and L.S. Adair. Univ. of North Carolina at Chapel
Hill.
D52 II1055.18Fluid consumption by Mexican women
during pregnancy and first semester of lactation. H. Martinez.
Children’s Hosp. “”Dr. Federico Gómez””, Mexico City and
RAND Corp., Santa Monica, CA.
D53 I1055.19
Waist circumference and waist:hip ratio
predict hypertension and diabetes risk better than body mass
index among Filipinos. C. Acuin and C. Duante. Univ. of the
Philippines, Cornell Univ., San Diego and Food and Nutr. Res.
Inst., Taguig, Philippines.
D54 II1055.20Prospective analysis of the formulation
of country-level plans of a regional health partnership. W.
Gonzalez, E.A. Frongillo and J.F. Thrasher. Univ. of South
Carolina.
D55 I1055.21
Anthropometric differences and body
composition among ethnic minorities in northern Vietnam. P.H.
Nguyen, B. Katz, A.E. Lowe, H. Nguyen, T. Truong, H. Pham,
S. Nguyen, G.A. Reinhart, K.B. Harding, L.M. Neufeld,
R. Martorell and U. Ramakrishnan. Thai Nguyen Univ. of
Pharm. and Med., Vietnam, Intl. Food Policy Res. Inst., Hanoi,
Columbia Univ., Emory Univ., The Mathile Inst., Dayton and
Micronutrient Initiative, Ottawa.
D56 II1055.22Process evaluation of a communitybased pilot intervention for chronic disease prevention in
Guatemalan school-aged children. P. Letona, J. Gittelsohn,
V. Chacon, M. Ramirez-Zea and B. Caballero. INCAP,
Guatemala City and Johns Hopkins Bloomberg Sch. of Publ.
Hlth.
D57 I1055.23
Preventing the global burden of type 2
diabetes by improving the quality of staple foods: The Global
Nutrition and Epidemiologic Transition Initiative. J. Mattei, V.
Malik, N.M. Wedick, D. Spiegelman, F.B. Hu, W.C. Willett
and H. Campos. Harvard Sch. of Publ. Hlth. and Univ. of
Massachusetts Med. Sch.
D58 II1055.24Prevalence and determinants of
hyperhomocysteinemia in school aged children in rural Nepal.
K.J. Schulze, M. Yakub, P. Christian, C.P. Stewart and K.P.
West, Jr. Johns Hopkins Bloomberg Sch. of Publ. Hlth. and
Univ. of California, Davis.
D59 I1055.25
The changing influence of wealth,
education and urbanization on overweight and obesity in
Guatemalan women between 1995 and 2008. R. Kanter, M.P.
Fort, M. Ramirez and R. Martorell. INCAP, Guatemala City
and Rollins Sch. of Publ. Hlth., Emory Univ.
D60 II1055.26Relationships between overweight,
inflammation, and iron status in women in the 2006 Mexican
National Health and Nutrition Survey (ENSANUT). S.V. Luna,
J.D. Haas, T. Shamah and S. Villalpando. Cornell Univ. and
Natl. Inst. of Publ. Hlth., Cuernavaca.
D61 I1055.27
Physical activity and sedentary behavior
in South Indian adults: urbanicity, gender, and obesity. V.R.
Chomitz, S.S. Prabhu, S. Thanikachalam, H. Vijayakumar,
K.K.H. Chui, A. Must, O. Bermudez and M. Thanikachalam.
Tufts Univ.,Boston, Sri Ramachandra Univ., India and The Ohio
State Univ.
349
T
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NUTRITIONTUESDAY
D62 II1055.28Iron and diabetes risk among Filipino
women. A. Feranil, N. Lee, I. Bas, F. Largado and L. Adair.
Univ. of San Carlos, Philippines and Univ. of North Carolina at
Chapel Hill.
D63 I1055.29
Low calcium intake is associated with
increased blood pressure among Filipino women. N.R. Lee, I.
Bas, F. Largado, J. Borja, P. Duazo and L. Adair. Univ. of San
Carlos Ofc. of Popul. Studies Fndn. Inc., Philippines and Univ.
of North Carolina at Chapel Hill.
D64 II1055.30Low meats and sweets diet attenuates
the effect of overweight duration on glucose levels among
Filipino women. P. Duazo, N. Lee, I. Bas, F. Largado, J. Borja
and L. Adair. Univ. of San Carlos-Ofc. of Popul. Studies Fndn.
Inc, Philippines and Univ. of North Carolina at Chapel Hill.
D65 I1055.31
A gauge repeatability and reproducibility
study applied to the measurements from the ENSANUT-2012
anthropometric training. R. Garcia-Feregrino and A.D.
Quezada-Sanchez. Natl. Publ. Hlth. Inst., Cuernavaca.
1056.NUTRITION AND THE MICROBIOME
Poster
(Sponsored by: Medication Nutrition Council (MNC))
Exhibit Halls A-B
D66 I1056.1Soluble corn fiber modulates calcium
absorption by altering colonic microbiota. C.M. Whisner, C.H.
Nakatsu, B.R. Martin, L.D. McCabe, G.P. McCabe and C.M.
Weaver. Cornell Univ. and Purdue Univ.
D67 II1056.2Shifts in the fecal microbial community
composition are associated with dietary fiber solubility. F.
Yang, N. Chia, L.B. Schook and B.A. White. Univ. of Illinois at
Urbana-Champaign and Mayo Clin.
D68 I1056.3Increased gut microbiome diversity
following a high fiber Mediterranean style diet. N. Steinle,
S. Cirimotch, K. Ryan, C. Fraser, A. Shuldiner and E.
Mongodin. Univ of Maryland Sch of Med. and Baltimore VA
Med. Ctr.
D69 II1056.4Compound seropositivity of neutralizing
antibodies against adipogenic adenoviruses (ADV36+ and
ADV37+): no additive effect on overweight-obesity and on
insulin resistance (IR-HOMA). The microbiome across the
obesity and into the liver. G.M. Trovato, D. Catalano, G.F.
Martines, F.M. Trovato, A. Garozzo, C. Pirri and A. Tonzuso.
Univ. of Catania and Policlin.-VE, Catania, Italy.
D70 I1056.5A 50:50 blend of insoluble and soluble
fibers added to enteral formula increases fermentation and
prevents decline in gut bacteria. K. Koecher, W. Thomas and
J. Slavin. Univ. of Minnesota, St. Paul and Minneapolis.
D71 II1056.6Determining the gut microbiotaindependent effects of prebiotic fiber in diet-induced obese rats.
M. Bomhof, H. Skochylas and R. Reimer. Univ. of Calgary,
Canada.
D72 I1056.7Effects of unsaturated fatty acids
on human gut microbiome profile in a subset of canola oil
multicenter intervention trial. S. Pu, H.R. Khazanehei, D.O.
Krause, S.G. West, P.M. Kris-Etherton, D.J. Jenkins, B.
Lamarche, P.J. Jones and E. Khafipour. Univ. of Manitoba,
Penn State, Univ. of Toronto and Univ. Laval, Canada.
350
D73 II1056.8The healthy eating index and the
intestinal microbiome in HIV infection. G. Volpe, H. Sheehan,
A. Tang, C. Duffalo, D. Dinh, D. Landy, H. Ward, A. Kane and
C. Wanke. Tufts Univ., Boston, Tufts Med. Ctr. and Univ. of
Miami.
D74 I1056.9Purple-fleshed
potatoes
suppress
colon-systemic oxidative stress/inflammatory markers via
alternations in the gut bacterial signature. L. Reddivari, S.W.
Kim, S. Radhakrishnan, P. Yang, R. Knight and J. Vanamala.
Colorado State Univ. , North Carolina State Univ., Univ. of Texas,
MD Anderson Cancer Ctr. and Univ. of Colorado Boulder.
D75 II1056.10Biotransformation
of
polymethoxyflavones by mouse and human colonic microflora.
C. Ma, J. Zheng, T. Warnick, S. Leschine and H. Xiao. Univ. of
Massachusetts Amherst.
D76 I1056.11
Past international residence and current
gut microbiome. C. Frankenfeld, J.K. Poudrier, M. Sikaroodi,
N. Waters, S. Shoemaker and P.M. Gillevet. George Mason
Univ.
D77 II1056.12Sorghum-based dietary intervention
enriches Faecalibacterium prausnitzii in fecal samples of
overweight individuals. D.V. Seidel, I. Martínez, S.S. Taddeo,
R. Zoh, M.D. Haub, J. Walter and N.D. Turner. Texas A&M
Univ., Univ. of Nebraska-Lincoln and Kansas State Univ.
D78 I1056.13
The impact of long-term storage
on fermentability of human fecal bacteria. K. Racicot , S.
Arcidiacono, C.Y. Chen and J. Soares. U.S. Army Natick
Soldier Ctr. and Tufts Univ., Boston.
D79 II1056.14High protein diet reduces food intake
and adiposity and alters GI microbiome. K. Pioli, C. Barbieri, I.
Cann, R. Mackie and J. Beverly. Univ. of illinois, Urbana and
Univ. of North Carolina at Greensboro.
D80 I1056.15
A study of the effects of the delivery
system on the efficacy of the probiotic Bifidobacterium
animalis subsp. lactis BB-12 in mediating colonic transit time
and improving immune function. S. Holligan, R.F. Roberts,
P.M. Kris-Etherton, J.A. Fleming, Z. Ba, K.E. Polizzano, E.J.
Furumoto and C.J. Rogers. Penn State.
D81 II1056.16Use of urinary markers of the gut
microbiome in epidemiological studies: the case of bisphenol
A concentrations in relation to enterolactone and enterodiol
concentrations. C. Frankenfeld and P. Gillevet. George
Mason Univ.
1057.INTERVENTIONS FOR THE TREATMENT
AND PREVENTION OF NUTRITION-RELATED
DISEASES
Poster
Exhibit Halls A-B
D82 I1057.1The effect of one Hass avocado per day
on cardiovascular disease risk factors. L. Wang, P.L. Bordi,
J.A. Fleming and P.M. Kris-Etherton. Penn State.
TUESDAYNUTRITION
D83 II1057.2Factors
influencing
the
25-hydroxyvitamin D level of pregnant women and their
newborns in Giessen, Germany. C. Wuertz, P. Gilbert, W.
Baier and C. Kunz. Inst. of Nutr. Sci. , Germany, St. Josefs
Hosp. Balserische Fndn., Germany and Lab. Med. Dres. med.
Wisplinghoff and Colleagues, Germany.
D84 I1057.3Insulin-sensitizing
effects
of
an
isocaloric diet containing soluble fiber-enriched flour in nonobese non-diabetic subjects. M.M. Corsi Romanelli, S.
Briganti, S. Goggi, F. Ermetici, R. Zelaschi, C. Oggioni, D.
Ignaccolo, M. Orsi, L. Morricone and A.E. Malavazos. Univ.
of Milan and IRCCS Polyclin. San Donato, Milan.
D85 II1057.4The association between diet and acne.
J.C. Burris, W. Rietkerk and K. Woolf. NYU and New York
Med. Col.
D86 I1057.5Effects of mango supplementation on
body weight and composition and clinical parameters of obese
individuals. S.F. Evans, M. Meister, S. Peterson, P. PerkinsVeazie, S. Clarke, M. Payton, B. Smith and E. Lucas.
Oklahoma State Univ. and North Carolina State Univ. Res.
Campus.
D87 II1057.6Effect of the glutathione S-transferase
M1 and Tl polymorphism on the blood pressure, lipid profiles,
and the blood glucose of Korean subclinical hypertensive
patients after kale juice supplementation. M-H. Kang, J-H.
Han, H-J. Lee and T.S. Kim. Hannam Univ., South Korea and
Pulmuone Hlth. & Living Co. Ltd., Seoul.
D88 I1057.7Effectiveness of insulin pump use in
regulating blood glucose in type 1 diabetes mellitus patients.
N.M. Nemeh-Saad and A.M. Mistry. Sch. of Hlth. Sci., Easter
Michigan Univ.
D89 II1057.8Omega-3 fatty acid supplementation
does not alter insulin sensitivity or serum adiponectin in healthy
Hispanic women. S.E. Deemer, G.A. King, M.S. Hickey and
C.L. Melby. Colorado State Univ. and Univ. of Texas at El Paso.
D90 I1057.9Moderate hyperglycemia and a blunted
anabolic response to perioperative parenteral amino acids in
type 2 diabetes mellitus patients undergoing colorectal cancer
surgery. A. Manjrekar, E. Nitschmann, R. Lattermann, T.
Schricker and L. Wykes. Sch. of Dietetics and Human Nutr.,
McGill Univ.
D91 II1057.10Anti-asthmatic
of
Lactobacillus
paracasei subsp. paracasei NTU101 in OVA-induced asthmatic
mice. W-K. Huang, J-H. Cai, M. Koriui and H-Y. Huang. Shih
Chien Univ., Taiwan.
D92 I1057.11
Long
term
supplement
AGVisomaltooligosaccharides drink into water can moldulate the
gut microflora in rats. Y-C. Lin, C-P. Hsu, M-S. Peng, S-W. Lin
and H-Y. Huang. Shih Chien Univ., Taiwan.
D93 II1057.12A
meta-analysis
of
randomized
controlled trials of Internet-based diabetes self management
intervention in patients with type 2 diabetes. Y. Kim and H.
McCollum. Louisiana Tech Univ.
D94 I1057.13
A moderate-fat diet with pistachios
lowers small-dense LDL and improves markers of insulin
sensitivity in subjects with moderately-elevated cholesterol
levels. S. Holligan, S.G. West, S.K. Gebauer, C.D. Kay and
P.M. Kris-Etherton. Penn State, USDA, Beltsville and Norwich
Med. Sch., Univ. of East Anglia, U.K.
D95 II1057.14The effect of more vegetable intake on
risk factors for cardiovascular disease in hemodialysis patients.
P.Y. Wu, Y-i.F. Chiu, Y-J. Lu, H-H. Chen, C-T. Su and S-H.
Yang. Sch. of Nutr. and Hlth. Sci., Div. of Nephrol. and Dept. of
Family Med., Taipei City.
D96 I1057.15
Lathosterol to cholesterol ratio in serum
predicts cholesterol lowering response to plant sterol therapy
in a dual center, randomized, single-blind placebo controlled
trial. D.S. MacKay, S. Gebauer, D. Baer and P. Jones. Univ. of
Manitoba and USDA, Beltsville.
D97 II1057.16A randomized controlled trial of genetic
information on dietary intake. D. Nielsen and A. El-Sohemy.
Univ. of Toronto and Nutrigenomix Inc., Toronto.
D98 I1057.17
Genetic control of serum 1,25
dihydroxyvitamin D level under normal and low dietary calcium
conditions. R.A. Replogle, L. Wang, M. Zhang and J.C. Fleet.
Purdue Univ.
1058.PRENATAL NUTRIENT PROGRAMMING
Poster
Exhibit Halls A-B
D99 I1058.1Iron status is associated with auditory
brainstem response measures in newborns. S. Lee, R. Guillet,
M. Orlando, E. Cooper, E. Pressman, R.A. Queenan and
K.O. O’Brien. Cornell Univ. and Univ. of Rochester Sch. of
Med. and Dent.
D100 II1058.2Prebiotic fiber diet does not improve
offspring ‘leaky gut’ from maternal low protein diet. M.C. Hallam
and R.A. Reimer. Univ. of Calgary, Canada.
D101 I1058.3A high protein:low carbohydrate diet
during pregnancy affects glucose metabolism in last trimester
sows and fetuses and leads to intrauterine growth restriction.
C.C. Metges, S. Görs, I. Lang, K. Brüssow, H.M. Hammon,
C. Rehfeldt and W. Otten. Leibniz Inst. for Farm Animal Biol.,
Dummerstorf, Germany.
D102 II1058.4An in vivo model for human fetal
adipose tissue development. J.A. Sanders, O. Onikoyi and
P.A. Gruppuso. Rhode Island Hosp. and Alpert Med. Sch. of
Brown Univ.
D103 I1058.5Iron status in multiples and their
neonates. Y. Ru, E.K. Pressman, R. Guillet, B.M. Cooper, P.J.
Katzman, S. Caveglia and K. O’Brien. Cornell Univ. and Univ.
of Rochester Med. Ctr.
D104 II1058.6Inrauterine growth retardation results in
altered metabolism and elevated preadipocyte proliferation in
pigs. K.M. Ajuwon. Purdue Univ.
D105 I1058.7Effect of Chdh deletion on mouse fetal
neurogenesis and apoptosis. S. Lao, A.R. Johnson, M.G.
Mehedint, Y-W. Teng, S. Zhang and S.H. Zeisel. Univ. of
North Carolina at Chapel Hill Gillings Sch. of Global Publ. Hlth.
and Univ. of North Carolina at Chapel Hill, Kannapolis.
D106 II1058.8Vitamin D deficiency in cord plasma
from multiethnic subjects living in the tropics. B.M. Halm, J.F.
Lai, I. Pagano, W. Cooney, R.A. Soon and A.A. Franke. Univ.
of Hawaii Cancer Ctr., Kapiolani Med. Ctr. for Women and
Children and Univ. of Hawaii John A. Burns Sch. of Med.
351
T
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NUTRITIONTUESDAY
1059.RESEARCH WITH DIETARY SUPPLEMENTS
AND BIOACTIVE COMPONENTS
Poster
(Sponsored by: Nutritional Epidemiology RIS)
Exhibit Halls A-B
D107 I1059.1Associations between urinary soy
isoflavones and inflammatory markers in adults in the
United States in 2005-2008. H.L. Nicastro, A.M. Mondul, S.
Rohrmann and E.A. Platz. NCI, NIH, Rockville, Univ. of Zurich
and Johns Hopkins Bloomberg Sch. of Publ. Hlth.
D108 II1059.2Predictors of vitamin D status in subjects
that consume a vitamin D supplement. M.A. Levy, A. Dern, T.
Barker, E. Schneider, T. McKinnon, J. Robertson, J. Cuomo,
T. Wood and B.M. Dixon. USANA Hlth. Sci., Salt Lake City and
Orthoped. Specialty Hosp., Muray, UT.
D109 I1059.3Comparative bioavailability of tableted
water-soluble olive polyphenols with and without phospholipid
micelle incorporation in humans. J.A. Templeton, H. Goldfine,
E. Schneider, T. McKinnon, J. Cuomo, B.M. Dixon and M.A.
Levy. USANA Hlth. Sci. Inc., Salt Lake City.
D110 II1059.4Vitamin D supplement use by adult
Canadians: sociodemographic correlates. S.I. Barr and T.J.
Green. Univ. of British Columbia.
1060.ASSESSMENT OF CHILD AND ADOLESCENT
NUTRITIONAL STATUS, GROWTH AND OBESITY
Poster
Exhibit Halls A-B
D111 I1060.1Iodine and iron deficiency and parasites
in children of Arandas, Mexico during the nutrition transition.
E.M. Vasquez-Garibay, L.R. Campos Barrera, E. Romero
Velarde, M.E. Nuño Cosio, R. Troyo Sanroman, L. Miranda
Rios, F. Napoles Rodriguez, A.R. Del Angel and F. Velarde.
Univ. of Guadalajara and Inst. Alteño para el Desarrollo de
Jalisco, Mexico.
D112 II1060.2Beyond calcium status obesity would
impair bone mineralization in school age children of both sexes:
preliminary report. M.E. Rio and H. Dupraz. Univ. of Buenos
Aires.
D113 I1060.3What are U.S. children under two
eating? Results from NHANES (2003-2008). S. Keim, A.M.
Branum and J. Peck. Nationwide Children’s Hosp., The Ohio
State Univ. Col. of Med., Ctrs. for Dis. Control and Prevent.,
Hyattsville, MD.
D114 II1060.4Vitamin D status, sun exposure and
lipid profile among adolescents living in São Paulo, Brazil. K.V.
Giudici, M.A. Lopes, D.M.L. Marchioni, R.M. Fisberg and
L.A. Martini. Univ. of São Paulo.
D115 I1060.5Infant feeding practices and challenges:
a pilot-study in Lebanon. N. Hwalla, F. Naja, T. Fossian, D.
Zebian and L. Nasreddine. American Univ. of Beirut.
352
D116 II1060.6When obesity begins: anthropometric
and demographic characteristics of California WIC child
participants. P.C. Papathakis, A. Nazmi, S. Phelan and P.
Engle. Cal Poly San Luis Obispo.
D117 I1060.7Nutritional deficits in juvenile endstage renal disease in a Guatemalan context. J. Casimiro, R.
Lou-Meda, N.W. Solomons and K. Schümann. Tech Univ.
München and Roosevelt Hosp. and CeSSIAM, Guatemala City.
D118 II1060.8Contrubution of snacks to total nutrient
intake by normal and overweight Puerto Rican children at
three different school levels. A.M. Preston, H. Venegas, R.M.
Velez-Rodriguez, C.A. Rodriguez and N. Rodriguez. Univ. of
Puerto Rico-Med. Sci. Campus.
D119 I1060.9Association of body mass index and
waist circumference with metabolic alterations in children from
Arandas, Jalisco, Mexico. E. Romero-Velarde, E.M. VásquezGaribay, L. Miranda-Rios and M.E. Nuño-Cosío. Univ. of
Guadalajara, Mexico.
D120 II1060.10Factors associated with adherence to
the dietary management of children and adolescents with type
1 diabetes mellitus. E. Romero-Velarde, R.V. León-Robles,
E. Vásquez-Garibay, C. Hunot-Alexander, B. VizmanosLamotte and L. Aguirre-Salas. Univ. of Guadalajara and
Hosp. Civil of Guadalajara.
D121 I1060.11
Serum levels of coenzyme Q10,
tocopherols, and C-reactive protein in adolescent girls and
premenopausal women. W. Chai, R. Novotny, R.V. Cooney, G.
Maskarinec, A.A. Franke and L. Le Marchand. Logan Col.,
MO and Univ. of Hawaii.
D122 II1060.12Body image perception among preadolescent children participating in a nutrition and physical
activity intervention program. A. McCann, T. Kemmer, H. Wey
and B. Jensen. South Dakota State Univ.
D123 I1060.13
Higher dairy calcium intake compared to
other dietary sources of calcium is associated with decreased
whole body and regional adiposity in adolescent girls. D.M.
Vassallo, D. Laddu, V. Lee, R. Blew and S. Going. Univ. of
Arizona.
D124 II1060.14“...and we took the median of the
three values”: optimal treatment of replicate measurements in
anthropometric studies. E. Villamor and R.J. Bosch. Univ. of
Michigan Sch. of Publ. Hlth. and Harvard Sch. of Publ. Hlth.
D125 I1060.15
Can teens accurately report their
weight, height, and waist and hip circumferences? G.S. Siapco,
S. Alomairah and J. Sabate. Sch. of Publ. Hlth., Loma Linda
Univ.
D126 II1060.16Infant dietary intake is associated with
weight gain from 1 to 12 months of age. S. Gallo, C. Vanstone,
C. Rodd and H.A. Weiler. Sch. of Dietetics and Human Nutr.,
McGill Univ. and Montreal Children’s Hosp.
D127 I1060.17
Regular soy intake supports normal
growth of teens and has no effect on risk of obesity. J. Sabaté,
T. Norkunas, L. Huey and G. Segovia-Siapco. Loma Linda
Univ.
D128 II1060.18Fructose, sweetened food and beverage
intake and metabolic markers in children. C. County, A.
Thomas, P.M. Catalano and N.L. Nock. Case Western
Reserve Univ. and MetroHlth. Med. Ctr.
D129 I1060.19
Accuracy of weight perception following
KidQuest intervention in rural South Dakota elementary
students. T.M. Kemmer, H. Wey, A. McCann and B. Jensen.
South Dakota State Univ.
TUESDAYNUTRITION
D130 II1060.20A prospective study of body image
dissatisfaction and BMI change in school children. O. Duchin,
M. Mora-Plazas, C. Marin, C. Mendes de Leon, J.M. Lee, A.
Baylin and E. Villamor. Univ. of Michigan Sch. of Publ. Hlth.,
Res. Fndn. for Nutr. and Hlth., Bogota and Univ. of Michigan
Hlth. Systs.
D131 I1060.21
Selecting items of a food behavior
checklist for the development of nutrition quotient for children in
Korea. M-H. Kang, J-S. Lee, H-Y.P. Kim, S. Kwon, Y-S. Choi,
H.R. Chung, T-K. Kwak, H-J. Lee and Y-H. Cho. Hannam
Univ., FANSA, Seoul, Yongin Univ., Daegu Univ., Nutr. for the
Future Inc., Seoul, Yonsei Univ., South Korea and Amway
Korea, Seoul.
D132 II1060.22Early rapid weight gain is associated
with overweight and obesity at 8 years in a breastfed population
in Peru. M.E. Penny and M. Marin. Nutr. Res. Inst., Lima, Peru.
D133 I1060.23
Development of a nutrition quotient
equation modeling for children and the evaluation of its
construct validity in Korea. H-Y.P. Kim, S. Kwon, J-S. Lee, Y-S.
Choi, H.R. Chung, T-K. Kwak, J. Park, H-J. Lee and M-H.
Kang. Yongin Univ., Hannam Univ., FANSA, Seoul, Daegu
Univ., Nutr. for Future Inc., Seoul, Yonsei Univ., South Korea
and Amway Korea, Seoul.
D134 II1060.24Using principal component analysis to
characterize dietary patterns in children from Uruguay. Y. Lee,
P.Y. Hsiao, E. Queirolo, F. Peregalli and K. Kordas. Penn
State and Catholic Univ. of Uruguay.
D135 I1060.25
Anthropometric measurements, dietary
intakes, mealtime and other behaviors of children with autism.
S.M. Ekvall, P. Fugazzi, F. Stevens and V. Ekvall. Univ of
Cincinnati and Cincinnati Children’s Hosp. Med Ctr.
D136 II1060.26Dietary intakes of children from birth to
24 months: What We Eat in America NHANES 2007-2010. D.G.
Rhodes, M.E. Adler, J.C. Clemens, J.D. Goldman and A.J.
Moshfegh. USDA, Beltsville.
D137 I1060.27
Fat imaging via magnetic resonance
imaging in young children (ages 1-4 years) without sedation.
G.E. Shearrer, B. House, J. Luci and J. Davis. Univ. of Texas
at Austin.
D138 II1060.28Vitamin D, calcium, potassium and
calorie intakes associated with distinct breakfast patterns in
children (NHANES 2001-2008). E.E. Quann, V.L. Fulgoni III
and N. Auestad. Natl. Dairy Council, Rosemont, IL and Nutr.
Impact LLC, Battle Creek, MI.
D139 I1060.29
Beverage consumption among schoolage children of different race/ethnic backgrounds from the
National Health and Nutrition Examination Survey. E.E.
Quann, N. Auestad and V.L. Fulgoni III. Natl. Dairy Council,
Rosemont, IL and Nutr. Impact LLC, Battle Creek, MI.
POSTER PRESENTERS:
UPLOAD YOUR POSTER
Where: E-Poster Counter, Sun. – Tue. Hall A; Wed. Hall C
Deadline: Tue., April 23, 5:00 pm; Wed., April 24, 3:00 pm
Uploaded posters will be available online to all
registered attendees following the meeting at
www. experimentalbiology.org
1061.NUTRITION WITHOUT BORDERS:
EPIDEMIOLOGIC METHODS IN EXAMINING
HEALTH DISPARITIES AND NUTRITION
OUTCOMES IN DIVERSE POPULATIONS
Poster
Exhibit Halls A-B
D140 I1061.1The Hispanic dietary mosaic: assessing
the diet of women in Puerto Rico in the Atabey Study. M.
Schelske-Santos, C.M. Nazario, R.V. Rosario Rosado, I.
Mansilla-Rivera, J. Hernández, F.A. Ramírez Marrero, S.
McCann and J.L. Freudenheim. Univ. of Puerto Rico-Rio
Piedras, Univ. of Puerto Rico-Med. Sci., Roswell Park Cancer
Inst. and Univ. at Buffalo.
D141 II1061.2Sociodemographic, clinical, and lifestyle
factors associated with prostate cancer aggressiveness in a
population-based study. T.M. Vance, Y. Wang, L.J. Su, E.T.H.
Fontham, J.T. Bensen, J.L. Mohler, M-H. Chen and O.K.
Chun. Univ. of Connecticut, NCI, NIH, LSU Hlth. Sci. Ctr., New
Orleans, Sch. of Med., Univ. of North Carolina at Chapel Hill
and Roswell Park Cancer Inst.
D142 I1061.3Dietary total antioxidant capacity and
prostate cancer tumor stage among African and Caucasian
Americans in a population-based study. T.M. Vance, Y. Wang,
L.J. Su, E.T.H. Fontham, J.T. Bensen, J.L. Mohler, M-H. Chen
and O.K. Chun. Univ. of Connecticut, NCI, NIH, LSU Sch. of
Publ. Hlth., New Orleans, Sch. of Med., Univ. of North Carolina
at Chapel Hill and Roswell Park Cancer Inst.
D143 II1061.4Vitamin deficiencies are both risk
factors and protective against diverse urogenital and intestinal
infections in pregnant Ngabe women from Panama. M.E. Scott,
D. Gonzalez-Fernandez, E. Murillo, O. Sinisterra and K.G.
Koski. Sch. of Dietetics and Human Nutr., McGill Univ., Fac. of
Med., Univ. of Panama and Panamanian Ministry of Hlth.
1062.NUTRITION EDUCATION
Poster
(Sponsored by: Nutrition Education RIS)
Exhibit Halls A-B
D144 I1062.1Efficacy of interactive whiteboards as
teaching tools in the nutrition education of 1st and 2nd grade
students. L. Maddox, T. Crook, D. Gonzales and R. Hakkak.
Univ. of Arkansas for Med. Sci.
D145 II1062.2The effects of a 3-year worksite health
promotion program in male workers with metabolic syndrome.
S.W. Cho, J-Y. Kang, T-I. Choi and Y-K. Park. Grad. Sch. of
East-West Med. Sci. , Kyung Hee Univ., South Korea and Korea
Hydro & Nuclear Power Co. Ltd., Seoul.
D146 I1062.3Weight control attitude and nutrition
knowledge of Korean high school students by BMI. K.J. Chang
and H-Y. Cho. Inha Univ., South Korea.
353
T
U
E
NUTRITIONTUESDAY
D147 II1062.4A comparative study of unbalanced
eating habit and dietary pattern of middle school students in
Incheon area, Korea. Y. Kim and E. Lee. Inha Univ., South
Korea.
D148 I1062.5Dietary patterns of Korean elementary
school students in Incheon region. Y. Kim and B.H. Cho. Inha
Univ., South Korea.
D149 II1062.6Efficacy of an evidence-based food
guide for vegetarians and vegans. J.R. Knurick, L. Fladell and
C.S. Johnston. Arizona State Univ.
D150 I1062.7Innovation
in
dietetic
internship
education at Iowa State University. R.S. MacDonald, J.A.
Anderson, E. Bergquist, J.S. Johnson and L.S. Kruzich.
Iowa State Univ.
D151 II1062.8Dietary
behavior
and
nutrition
knowledge of Korean elementary students. K.J. Chang and
J-s. Jang. Inha Univ., South Korea.
D152 I1062.9iCook: developing a 4-H curriculum for
youth and adults. L. Franzen-Castle, M. Krehbiel, A. White, D.
Mathews, K. Yerxa, S. Colby, A. Donaldson, K. Kattelmann,
A. Koens, M. Olfert and S. Flanagan. Univ. of NebraskaLincoln, Univ. of Maine, Univ. of Tennessee, Knoxville, South
Dakota State Univ. and West Virginia Univ., Morgantown and
Martinsburg.
D153 II1062.10A web-based food value analysis
application to compare foods at different levels of processing.
M.K. Muth, S. Karns, M. Coglaiti, M. Zmuda, M. Koyanagi,
K. Duffey, C. Dunn, H. Jensen and C. Gregory. RTI Intl.,
Research Triangle Park, Virginia Tech, North Carolina State
Univ., Iowa State Univ. and Econ. Res. Svc., Washington, DC.
D154 I1062.11
White potato consumption is positively
associated with potassium intake. M.L. Storey and P.
Anderson. Alliance for Potato Res. & Educ., McLean, VA.
D155 II1062.12Korean middle school students’ dietary
habits and degree of satisfaction with school meals. Y. Kim and
H.Y. Kim. Inha Univ., South Korea.
D156 I1062.13
Training and professional development
barriers and opportunities in programs participating in the
National School Lunch Program. A.M. Jones, M. Punia, S.
Young, C. Chase and S. Zidenberg-Cherr. Univ. of California,
Davis, and California Dept. of Educ. and Dairy Council of
California, Sacramento.
D157 II1062.14Motivating Me: Healthy Minds, Healthy
Bodies: development of a psychoeducational program for
obese children. A.M. Maia and A.A. White. Univ. of Maine.
1063.PREVENTING CHILDHOOD OBESITY
Poster
(Sponsored by: Nutrition Education RIS)
Exhibit Halls A-B
D158 I 1063.1Withdrawn.
D159 II1063.2Fathers’ buying habits related to
increased sweetened beverage consumption in preschool
children. A.S. Coleman and A.M. Ferris. Univ. of Connecticut,
East Hartford.
354
D160 I1063.3Using focus groups to inform an
intervention to promote adoption of the DGA among African
American children in the lower Mississippi Delta. B.B. McGee,
V. Richardson, G. Johnson and C. Johnson. Southern Univ.
and A&M Col.
D161 II1063.4Food choices for 2-5-year-old children
in California childcare: comparing 2008 and 2012. S. Sharma,
S. Yoshida, E. Braff-Guajardo and L.D. Ritchie. Univ. of
California, Berkeley, Samuels and Assocs., Oakland and
California Food Policy Advocates, Oakland.
D162 I1063.52010-2011 USDA fresh fruit and
vegetable program improved Indiana elementary students’
consumption of fruit. L. Huang, Y-C. Lin, E. Foland, Y. Bai, Y.
Liu and A.D. Fly. Sch. of Publ. Hlth., Indiana Univ., Indiana
Dept. of Educ., Indianapolis and Montclair State Univ.
D163 II1063.6Associations between knowledge and
attitudes about sports drinks and sports drink intake among
U.S. youth. D. Zytnick, S. Park and S.J. Onufrak. Ctrs. for Dis.
Control and Prevent.
D164 I1063.7Medical student initiative of monitoring
USDA nutritional guidelines adherence with novel application of
digital photography in elementary school meals. D. Monlezun,
A. Rodman, B. Telsey, B. Leong, L. Abu-Shamat, D. Kay, D.
Green, L. Sarris and T. Harlan. Tulane Univ. and Tulane Univ.
Sch. of Med.
D165 II1063.8The relationship between infant-feeding
attitudes and practices and infant weight at 2 and 4 months of
age. K.M. Bower, J.C. Nicklas, A.N. Sberna, J.J. Waller, J.L.
Burney, B.P. Greer and K.F. Kavanagh. Univ. of Tennessee,
Knoxville.
D166 I1063.9Use of digital messages to increase
parental engagement in an after-school obesity prevention
program. L. Miesel, M. Spence, C. Perry-Burst, A. McDonald
and J. Beason. Univ. of Tennessee, Knox Cty. Schs. and
Tennova Healthcare, Knoxville.
D167 II1063.10After-school
obesity
prevention
programs: are engaged parents a myth or reality? M. Spence,
A. McDonald and C. Perry-Burst. Univ. of Tennessee,
Knoxville and Knox County Schs., TN.
D168 I1063.11
Food as a reward and weight status
in children with autism. L. Bandini, C. Curtin, S. Anderson,
S. Philips and A. Must. Univ. of Massachusetts Med. Sch.,
Boston Univ., The Ohio State Univ. Col. of Publ. Hlth. and Tufts
Univ. Sch. of Med.
D169 II1063.12Parent reports of young children’s
sensory characteristics are related to children’s food
neophobia. S.L. Johnson, P. Davies, R.E. Boles, W. Gavin
and L. Bellows. Univ. of Colorado Anschutz Med. Campus and
Colorado State Univ.
D170 I1063.13
Perceptions of factors and messages
related to childhood obesity among Mexican-origin parents.
L.E. Vera-Becerra, A. Aguilera, L. Kaiser, R. Manzo and
A. de la Torre. Sch. of Med. and Nutr., Univ. of Guanajuato,
Mexico and Sch. of Educ., Univ. of California, Davis.
D171 II1063.14Strength of association of dietary
factors and physical activity with obesity and body fat in school
children in Mexico City. D. Barrera, M. Perez-Rodriguez, N.
Vega, E. Gamez, G. Leyva, F. Pfeffer and A. Ortiz. Mexican
Hlth. Fndn., Tlalpan.
D172 I1063.15
Obesity prevention in preschool-aged
children: the importance of sleep. D. Golem, J. Martin-Biggers,
J. Worobey and C. Byrd-Bredbenner. Col. of Hlth., Human
Svcs. and Sci., Ashford Univ., CA and Rutgers, The State Univ.
of New Jersey.
TUESDAYNUTRITION
D173 II1063.16Relationship of body mass index to
screen time in head start participants in Central Arkansas. B.
Timmerman, T. Crook, D. Gonzales, L. Maddox, K. Smith, C.
Feild and R. Hakkak. Univ. of Arkansas for Med. Sci.
D174 I1063.17
Healthy lifestyle telephone group
counseling for children and their families. C.A. Gibson, R.J.
Sol, S. Staubach, J.L. Greene, J.H. Lee, C.C. Pritchard, D.K.
Sullivan and D. Davis. Univ. of Kansas Med. Ctr., Univ. of
Kansas and Blue Cross, Kansas City, MO.
D175 II1063.18iCook: lessons learned about recruiting
youth and their primary adult food preparers for a 4-H cooking
intervention. M.D. Olfert, E. Smith, S. Flanagan, S.E. Colby,
K. Shanklin, A.A. White, D. Mathews, K. Yerxa, L. FranzenCastle, M. Krehbiel, K.K. Kattelmann and A. Koens. West
Virginia Univ., Univ. of Tennessee, Knoxville, Univ. of Maine,
Univ. of Nebraska, Scottsbluff and South Dakota State Univ.
D176 I1063.19
Simple Suppers: a family nutrition
education and cooking program delivered in the daycare setting
designed to improve diet quality in preschool aged children. A.
Wagner, A. Rose, J. Kennel and C. Gunther. The Ohio State
Univ.
D177 II1063.20Dairy intake and obesity risk among
teens. M. Nezami , G. Siapco and J. Sabate. Loma Linda Univ.
D178 I1063.21
The effects of dairy intake among
preschool aged girls and boys on their weight status. T.R.
Cohen, T.J. Hazell, S. Jean-Philippe, T. Pham, C.A. Vanstone,
C.R. Rodd and H.A. Weiler. Sch. of Dietetics and Human Nutr.,
McGill Univ., Univ. of Lethbridge, Canada, Children’s Hosp. of
Eastern Ontario Res. Inst. and Montreal Children’s Hosp.
D179 II1063.22Inclusion of peers in a school-based
obesity intervention. C.A. Johnston, J. Moreno, A. ElMubasher, M.A. Papaioannou and D. Woehler. Baylor Col. of
Med. and The Cluthe & William B. Oliver Fndn., Houston.
D180 I1063.23
Adherence to a multi-component weight
management program for Mexican American adolescents. C.A.
Johnston, M.A. Papaioannou, J.P. Moreno, A. El-Mubasher
and J.P. Foreyt. Baylor Col. of Med.
D181 II1063.24The impact of metabolic syndrome on
child weight outcomes in pediatric obesity program for Mexican
Americans. C.A. Johnston, J.P. Moreno, L. Green, A. ElMubasher, B.K. McFarlin and J.P. Foreyt. Baylor Col. of Med.
and Univ. of North Texas.
D182 I1063.25
The impact of acculturation level on
weight status and weight outcomes in Mexican American
children. C.A. Johnston, R. Cameron, S. Lyons, J.P. Moreno
and M.A. Papaioannou. Baylor Col. of Med., Sam Houston
State Univ. and George Washington Univ.
1064.EDUCATION AND TEACHING IN MEDICAL AND
OTHER PROFESSIONAL SCHOOLS
Poster
Exhibit Halls A-B
D183 I1064.1Dietary intake of sleep-deprived, oncall anesthesiology residents. M.K. Taylor, C.A. Gibson, G.K.
Unruh, L.T. Ptomey, K.R. Spaeth and D.K. Sullivan. Univ. of
Kansas Med. Ctr.
D184 II1064.2Teaching 3rd & 4th year medical
students how to cook: an innovative approach to balance
lifestyle modification and medication therapy in chronic disease
management. B. Leong, L. Abu-Shamat, D. Kay, D. Monlezun,
L. Sarris and T. Harlan. Tulane Univ.
D185 I1064.3Increasing medical student knowledge
of the urban nutrition climate through an orientation bus tour
and urban nutritition scavenger hunts. K. Ireland, M. Beste, V.
Halls, R. Jordan, C. Lenders and E. Hardt. Boston Univ. Sch.
of Med. and Sargent Col. of Hlth. and Rehabil. Sci.
D186 II1064.4Physician attitudes towards individuals
who are overweight. S. Garner, D. Gonzales, T. Crook and R.
Hakkak. Univ. of Arkansas for Med. Sci.
D187 I1064.5Dietary supplement education for the
military: an education module for healthcare providers. S.
Attipoe, R. Costello, M. Kohlmeier and P. Deuster. Uniformed
Svcs. Univ. of Hlth. Sci., ODS, NIH and Univ. of North Carolina
at Chapel Hill.
D188 II1064.6Online and campus students have
positive perceptions of an open educational resource, the
Kansas State University Human Nutrition (HN 400) Flexbook.
B. Lindshield and K. Adhikari. Kansas State Univ.
D189 I1064.7Nutrition, Behavior, and Mental Health:
a unique undergraduate course at the intersection of food
and mood. L. Chen and L.E. Murray-Kolb. Johns Hopkins
Bloomberg Sch. of Publ. Hlth. and Penn State.
D190 II1064.8Dentists’ dietary perception and
practice patterns in a dental practice-based research network.
Y. Yokoyama, N. Kakudate, F. Sumida, Y. Matsumoto, G.H.
Gilbert and V.V. Gordan. Japan Soc. for the Promotion of
Sci.. Suita, Stanford Univ. Sch. of Med., Nagayama Family
Dent. Clin., Sapporo, Wing Town Dent. Clin., Okazaki, Univ. of
Alabama at Birmingham and Univ. of Florida.
1065.NUTRITION TRANSLATION
Poster
(Sponsored by: Nutrition Translation RIS)
Exhibit Halls A-B
D191 I1065.1Perceptions and use of nutrition labeling
information. W.Y. Juan, Y. Zhang, M. Kantor and M. Ali. USDA,
College Park, MD.
D192 II1065.2Assessment of variation in methods
to determine reported iron content of nutrition labels of
commercial dark chocolate bars. R. Giusti and A. Kazaks.
Bastyr Univ., WA.
D193 I1065.3Impact of prompts with diet selfassessment tools in determining calcium intake in collegeaged adults. K. Plawecki, C.K. Kwan and K. ChapmanNovakofski. Benedictine Univ., IL, Univ. of Illinois, Urbana and
The Univ. of Hong Kong.
D194 II1065.4Expert
recommendations
for
consumption frequencies of specific foods. J.Y. Andrews
Chavez, J. Konick, C. Davis, E. Marino-Costello, P. Connell
and R.F. Houser. Tufts Univ. Friedman Sch. of Nutr. Sci. and
Policy, Tufts Univ. and Connecticut Col.
355
T
U
E
NUTRITIONTUESDAY
D195 I1065.5Development of 2010 Dietary Guidelines
for Americans menus for a randomized controlled-feeding study.
N. Schroeder, M-S. Kang, Y. Kim, G. Ha, Y-H. Park, H-R. Kim,
A. Yates and B. Caballero. USDA, Beltsville, Rural Develop.
Admin., Suwon, South Korea and Johns Hopkins Univ.
D196 II1065.6Child and adolescent dietary intake of
produce with high pesticide exposure. E.K. Kobernik and A.M.
Branum. Natl. Ctr. for Hlth. Stats., Hyattsville, MD.
D197 I1065.7School children’s acceptance of fat-free,
low added sugars flavored milk. B.A. Yon and R.K. Johnson.
Univ. of Vermont.
D198 II1065.8Dairy products consumption in French
children in 2010. C. Marmonier, E. Chazelle and B. Coudray.
CNIEL and CERIN, Paris.
D199 I1065.9Is there fruit in that? Children are misled
by television food advertisements. R. Heller, A. BerhauptGlickstein, J. Martin-Biggers and C. Byrd-Bredbenner.
Rutgers, The State Univ. of New Jersey.
D200 II1065.10Energy implications of eating out and
other diet behaviors in Filipino adults. I.N. Bas, F.G. Largado,
J.B. Borja, N.R. Lee and L.S. Adair. Univ. of San Carlos Ofc. of
Popul. Studies Fndn., Philippines and Univ. of Northa Carolina
at Chapel Hill.
D201 I1065.11
Comparison of main contributors to
dietary fiber and whole grain in Americans’ diet: NHANES
2003-2010. S. Kranz, K.W. Dodd, W. Juan and L.K. Johnson.
Purdue Univ., NCI, NIH, Rockville, FDA, College Park, MD and
USDA, Grand Forks.
D202 II1065.12Organic and genetically modified food:
consumer beliefs and behavior. J.C. Panchalk and A.M.
Mistry. Sch. of Hlth. Sci., Eastern Michigan Univ.
D203 I1065.13
Relationship between green eating and
environmental attitudes and behaviors in college students.
E. Vandeputte, J.T. Nash, K. Weller, G.W. Greene and I.E.
Lofgren. Univ. of Rhode Island.
D204 II1065.14The “”Green Eating”” project: a pilot
intervention to promote sustainable and healthy eating in
college students. J. Nash, K. Eastman, N. Mundorf and G.
Greene. Univ. of Rhode Island.
D205 I1065.15
Green eating and dietary quality in
university students. G.A. Brown, J. Arts, J.T. Nash, I.E.
Lofgren and G.W. Greene. Univ. of Rhode Island.
D206 II1065.16Environmentally conscious behavior at
three Northeastern universities. S.J. McPartland, J.T. Nash, K.
Melanson, R. Hall, A.A. White, T.M. Horacek and G. Greene.
Univ. of Rhode Island, Univ. of Maine and Syracuse Univ.
D207 I1065.17
HSCCC isolation and characterization
of walnut polyphenols with antioxidative and lipolytic activity.
M.H. Grace, S.A. Neff, C. Warlick, E. Ayoub, D. Esposito, M.
Wilson, S. Komarnytsky and M.A. Lila. North Carolina State
Univ., Kannapolis.
D208 II1065.18Nutrient composition of regular and low
sodium bacon. J. Dai and L. Thompson. Texas Tech Univ.
D209 I1065.19
The relevances of metabolic syndrome
with dietary habit and lifestyle in Korean middle-aged women.
H.J. Lee and K-H. Lee. Changwon Natl. Univ., South Korea.
D210 II1065.20Food insecurity and its association
with risky behaviors among tTanzanian adolescents. J.
Klingensmith and L.S. Cordeiro. Univ. of Massachusetts
Amherst.
356
D211 I1065.21
Assessing issue awareness and
messaging on purchasing behavior of fresh fruits and
vegetables in low-income populations. Y. Huang, B. Wuchner,
S. Thomas, E. Park, I. Edirisinghe and B. Burton-Freeman.
Illinois Inst. of Technol.
D212 II1065.22Bioaccessibilities of K, P, Fe and B
minerals in oleaster flour as a novel food ingredient. Y. Sahan,
A. Cansev, G. Celik and D. Gocmen. Uludag Univ. and Bursa
Test and Analysis Lab., Turkey.
D213 I1065.23
Antioxidant properties and their
bioaccessibility of blessed thistle under different processed
treatments. Y. Sahan and D. Dulger. Uludag Univ. and Istanbul
Aydýn Univ., Turkey.
D214 II1065.24Sandwiches are an important source of
both nutrients to increase and nutrients to reduce: results from
what we eat in America, NHANES 2009-2010. R.S. Sebastian,
C. Wilkinson Enns, J.D. Goldman and A.J. Moshfegh.
USDA, Beltsville.
D215 I1065.25
Anti-hyperglycemic effect of arginylfructose and arginyl-fructosyl-glucose in db/db mice model.
K-S. Ha, S-H. Jo, E. Apostolidis, C.M. Lee, Y-H. Kim, M.S.
Lee, H-D. Jang and Y-I. Kwon. Hannam Univ., South Korea,
Framingham State Univ., Univ. of Rhode Island and Chungnam
Natl. Univ., South Korea.
D216 II1065.26Resistant starch as a novel food
ingredient in human nutrition. D. Gocmen and A.N. Dundar.
Uludag Univ. Fac. of Agr. and Vocational Sch. of Y. Sehir Ibrahim
Orhan, Turkey.
D217 I1065.27
Oat usage in food production as a
bioactive component source. D. Gocmen, E. Aydin, A.Y. Kilci
and M. Aydin. Uludag Univ. Fac of Agr. and Vocational H.S. of
Keles, Turkey.
D218 II1065.28Evidence of revising calcium dietary
reference intakes for Korean elderly. Y-S. Choi, H. Joung and
J. Kim. Daegu Univ., South Korea and Seoul Natl. Univ.
1066.OBESITY: CARBOHYDRATE INTAKE AND
WEIGHT MANAGEMENT
Poster
(Sponsored by: Obesity RIS)
Exhibit Halls A-B
D219 I1066.1The ability of spices to increase
vegetable intake among overweight adults, measured by
a universal eating monitor. Z. Li, L.K. Brahe, A. Zerlin, A.
Rheinwald-Jones, M. Krak, G. Thames and D. Heber. UCLA
and Univ. of Copenhagen.
D220 II1066.2Inclusion of a high carbohydrate
meal with nutrition education decreases weight and body fat
more than education alone. M.C. Caamaño, D. Ronquillo,
O.P. García, G. Martínez-Peña, S. García-Padilla and J.L.
Rosado. Autonomous Univ. of Querétaro, Cindetec A.C. and
Kellogg de Mexico, Querétaro.
D221 I1066.3Iin vitro digestive enzyme inhibitory
effects of eight common spices and herbs. T. Moss-Pierce, Z.
Tu and A. Jiang. McCormick and Co. Inc., Hunt Valley, MD.
TUESDAYNUTRITION
D222 II1066.4High fructose corn syrup-sweetened
cola and the hypothalamus: a dose-response fMRI study. S.
Hudgins, A. Smaliy, W. Zhan, J.L. Leger, S. Gebauer, D.J.
Baer and T.W. Castonguay. Univ. of Maryland College Park
and USDA, Beltsville.
D223 I1066.5Sugar
sweetened
beverage
consumption is higher in normal weight than overweight and
obese adolescents: implications for future increased prevalence
of obesity. M. Rodriguez, R. Ortiz, P. Montez and S. Weffer.
Univ. of California, Merced and Northern Illinos Univ.
1067.OBESITY: CHRONIC DISEASES
Poster
Exhibit Halls A-B
D224 I1067.1Health
behaviors
index
for
cardiovascular disease prevention among young Brazilian
college students. K. Bousquet-Santos, D. Santos, A. Silva, P.
Bastos, G. Oliveira and I. Martins. Univ. of Brasilia.
D225 II1067.2Korean pine nut oil attenuated hepatic
TG accumulation in high-fat diet-induced obese mice. S. Park,
S. Shin, Y. Lim, J.H. Shin, J.K. Seong and S.N. Han. Seoul
Natl. Univ.
D226 I1067.3Vitamin E and vitamin C supplementation
does not prevent glucose intolerance in obese-prone rats. M.J.
Picklo. USDA, Grand Forks.
D227 II1067.4Fatty liver accompanies an increase of
Lactobacillus acidophilus in the hind gut of C57/BL mice fed
a high-fat diet. H. Zeng, J. Liu, M. Jackson, L. Yan and G.
Combs, Jr. USDA, Grand Forks and Mayo Clin., Scottsdale,
AZ.
D228 I1067.5Atypical
antipsychotics
attenuate
associations between linoleic acid and reduced markers of
metabolic syndrome. S.J. Evans, A.R. Prossin, M.G. McInnis,
C.F. Burant and V.L. Ellingrod. Univ. of Michigan Col. of
Pharm.
D229 II1067.6Do dietary behaviors of adult preterms
explain some of the elevated future risk of cardiovascular
disease? M. Sharafi, V.B. Duffy, R.J. Miller, S.B. Winchester
and M.C. Sullivan. Univ. of Connecticut, Women & Infants
Hosp., Providence and Univ. of Rhode Island.
D230 I1067.7Non-alcoholic fatty liver disease in nondiabetic subjects: independent relationship of dietary profile
and bright liver score with the severity of systolic heart function
impairment. G.M. Trovato, D. Catalano, G.F. Martines, F.
Carcò, D. Coco, D. Brischetto, A. Abate and F.M. Trovato.
Univ. of Catania and Polyclin.-VE, Catania, Italy.
D231 II1067.8High rate of overweight and obesity in
post-combat military service members and veterans exposed
to blast and/or blunt head trauma. K.N. Starr, C.A. Smith
Hammond, S.H. Candice, L. Markley, R. Sisk, C. Brown and
C.W. Bales. Duke Univ. Med. Ctr. and Durham VA Med. Ctr.
D232 I1067.9Reduction of metabolic syndrome by a
lifestyle-modification program is accompanied by improvements
of aerobic fitness and plasma antioxidant markers. F. Moreto,
R.M. Manda, K.C. Portero-McLellan, C.R. Correa and R.C.
Burini. Botucatu Sch. of Med., Brazil.
D233 II1067.10A high protein diet results in moderate
renal and hepatic damage but improves body size, glucose
handling and haptoglobin levels in diet-induced obese rats.
J.G. Devassy, N. Ibrahim, C.G. Taylor, P. Zahradka and H.M.
Aukema. Univ. of Manitoba and Canadian Ctr. for Agri-Food
Res. in Hlth. and Med., Winnipeg.
D234I1067.11
HbA1c levels in non-diabetic overweight
and obese subjects. L. Zago, A. Weisstaub, M.C. Masselli,
V. Ortiz, A.L. Felipoff, H. Dupraz, C. Perdomo, M.E. Rio, N.
Presner, S. Rivera and C. González Infantino. Fac. of Pharm.
and Biochem, Univ. of Buenos Aires, Clin. Hosp. and CONICET,
Buenos Aires.
D235 II1067.12Changes in cardiovascular risk factors
after 4-week consumption of two diet patterns: Korean and
2010 U.S. Dietary Guidelines. N. Schroeder, M-S. Kang, Y.
Kim, G. Ha, Y-H. Park, H-R. Kim, A. Yates and B. Caballero.
USDA, Beltsville, Rural Develop. Admin., Suwon, South Korea
and Johns Hopkins Univ.
D236 I1067.13
Response of serum osteocalcin to
caloric restriction with and without exercise in post-menopausal
women. A.J. Centi, S.L. Booth, C.M. Gundberg, B. Nicklas
and M.K. Shea. USDA at Tufts Univ., Yale Sch. of Med. and
Wake Forest Univ. Sch. of Med.
D237 II1067.14Adiponectin levels in individuals with
type 2 diabetes on a high fiber or a low glycemic index diet.
L.S.A. Augustin, S. Blanco Mejia, A. Mirrahimi, S. Mitchell,
P. Connelly, C.W.C. Kendall and D.J.A. Jenkins. St. Michael’s
Hosp., Toronto, Univ. of Toronto and Univ. of Saskatchewan.
1068.OBESITY: PHYSICAL ACTIVITY
Poster
Exhibit Halls A-B
D238 I1068.1Substituting dietary monounsaturated
fat for saturated fat is associated with increased daily physical
activity and resting energy expenditure and with changes in
mood. C.L. Kien, J.Y. Bunn, C.L. Tompkins, J.A. Dumas, K.I.
Crain, D.B. Ebenstein, T.R. Koves and D.M. Muoio. Univ. of
Vermont Col. of Med., Colchester and Burlington and Duke
Univ.
D239 II1068.2Effects of a dietary and Tai Chi
intervention on body composition in obese older women. J.
Bekke, J. Letendre, N. Beebe, F. Xu, I. Lofgren and M.J.
Delmonico. Univ. of Rhode Island.
D240 I1068.3Feasibility of current physical activity
recommendations for school age children. M. Perez-Rodriguez,
E. Gamez, J. Talavera, N. Vega, D. Barrera, F. Pfeffer, E. Tejero
and G. Melendez. Mexican Hlth. Fndn., Tlalpan, Mexican Inst.
of Social Security, Cuahtemoc and Natl. Inst. of Genomic Med.,
Tlalpan.
D241 II1068.4The
relationship
between
body
roundness, exercise dose, and exercise type. Y.L. Maeda, M.
Tibbi, M.J. Scott and S. Islam. Montclair State Univ.
D242 I1068.5Environmental barriers to children’s
summer outdoor play. J. Worobey, L. Lelah and R. Gaugler.
Rutgers Univ.
357
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D243 II1068.6Combined
effects
of
objectively
measured physical activity and serum 25-hydroxyvitamin D
status on type 2 diabetes risk among U.S. adults. J.E. Choi
and B.E. Ainsworth. Arizona State Univ.
D244 I1068.7Sedentary behavior and mortality in
older women. R. Seguin, D. Buchner, J. Liu, M. Allison, T.
Manini, J. Manson, C. Messina, M. Patel, L. Moreland and A.
LaCroix. Cornell Univ., Fred Hutchinson Cancer Res. Ctr., Univ.
of Illinois, Champaign, UCSD, Univ. of Florida, Harvard Med.
Sch., Stony Brook Univ., Duke Univ. and Univ. of Pittsburgh.
D245 II1068.8Decreasing physical activity is linked
with increased obesity in Henan Province, China. D. Zhang,
S. Zhang, X. Zhan, F. Chao and S. Du. Inst. of Publ. Hlth.,
Henan Ctr. for Dis. Control and Prevent., China and Univ. of
North Carolina at Chapel Hill.
D246 I1068.9Factors associated with physical
inactivity among women in Santos, Brazil. A.B. Trude, Y. Mui, J.
Giltensohn and P.A. Martins. Fed. Univ. of São Paulo, Brazil
and Johns Hopkins Bloomberg Sch. of Publ. Hlth.
1069.OBESITY: ENERGY EXPENDITURE
Poster
Exhibit Halls A-B
D247 I1069.1Comparison of dynamic model predicted
and actual weight gain during overfeeding: an energy balance
analysis. Y. Begum, S. Cupidon, T. Aftab and M. Anazodo.
Montclair State Univ., NJ.
D248 II1069.2Adaptive thermogenic response to over
and underfeeding occurs acutely. A. O’Connor, W. Luo, J.
Galanko, C. Brouwer and A.G. Swick. Univ. of North Carolina
Nutr. Res. Inst. and Univ. of North Carolina at Charlotte,
Kannapolis and Univ. of North Carolina at Chapel Hill.
1070.OBESITY: SOCIOECONOMICS
Poster
Exhibit Halls A-B
D249 I1070.1Public beliefs about involvement of
religious institutions with obesity. S. Stiles and J. Sobal.
Cornell Univ.
D250 II1070.2Associations between socioeconomic
status and dietary patterns in the REGARDS study population.
K.P. Kell, S.E. Judd, J.M. Shikany and J.R. Fernandez. Univ.
of Alabama at Birmingham Sch. of Publ. Hlth. and Sch. of Med.
358
1071.PHYSIOLOGY AND PATHOPHYSIOLOGY
Poster
Exhibit Halls A-B
D251 I1071.1Permethrin, a pyrethroid insecticide,
potentiates adipogenesis in 3T3-L1 adipocytes. J. Kim, Y. Park,
K.S. Yoon, J.M. Clark and Y. Park. Univ. of Massachusetts
Amherst and Korea Univ.
D252 II1071.2Metabolic status of adipocytes triggers
rapid adjustments of systemic glucose tolerance. C. Kless and
M. Klingenspor. Tech Univ. Munich, Freising.
D253 I1071.3Gender differences in hepatic lipogenic
and inflammatory genes after 72 hours of high fat diet. C. Miller,
P.T. Cooney, S. Rayalam, L.M. Brown and C.A. Baile. Univ.
of Georgia, Univ. of North Carolina at Greensboro and Sch. of
Pharm., Philadelphia Col. of Osteo. Med., Suwanee, GA.
D254 II1071.4Organochlorine insecticides potentiate
adipogenesis in 3T3-L1 adipocytes. J. Kim, Y. Park, K.S. Yoon,
J.M. Clark and Y. Park. Univ. of Massachusetts Amherst and
Korea Univ.
1072.POLYUNSATURATED FATTY ACIDS AND
HEALTH
Poster
(Sponsored by: Energy and Macronutrient Metabolism RIS)
Exhibit Halls A-B
D255 I1072.1Effects of age, sex, body mass index
and APOE genotype on cardiovascular biomarker response to
an n-3 polyunsaturated fatty acid supplementation. E. Thifault,
H. Cormier, A. Bouchard-Mercier, I. Rudkowska, S. Lemieux,
P. Couture and M-C. Vohl. Laval Univ., Canada.
D256 II1072.2Dietary fat source alters hepatic
gene expression profile and determines the type of liver
pathology in rats overfed via total enteral nutrition. M. Ronis, J.
Baumgardner, J. Marecki, L. Henning, X. Wu, K. Shankar, M.
Cleves, H. Gomez-Acevedo and T. Badger. Univ. of Arkansas
for Med. Sci.
D257 I1072.3Protective effects of different dietary
proportion of fish oil on hepatic injury in chronic ethanol-fed
rats. S-C. Yang, H-C. Peng, Y-L. Chen, W-H. Liao and X-D.
Wang. Sch. of Nutr. and Hlth. Sci., Taipei Med. Univ. and USDA
at Tufts Univ.
D258 II1072.4Tri-docosahexaenoic but not trieicosapentaenoic acid-rich emulsions are neuroprotective after
cerebral hypoxic-ischemic injury in mice. K. Mayurasakorn,
V.S. Ten and R.J. Deckelbaum. Columbia Univ. Med. Ctr.
D259 I1072.5Estrogen increases the conversion of
a-linolenic acid to docosahexaenoic acid in ovariectomized
mice. J.K. Mason, S. Kharotia, A.K.A. Wiggins, J. Chen and
L.U. Thompson. Univ. of Toronto.
TUESDAYNUTRITION
D260 II1072.6Expressional regulation of the leptin by
n-3 FA is related to the epigenetic modification of its promoter
in diet induced obese mice. C. Fan, W. Shen, C. Wang, R.
Deckelbaum and K. Qi. Beijing Children’s Hosp., Capital Med.
Univ. and Columbia Univ. Med. Ctr.
D261 I1072.7Risk factors for age-related macular
degeneration appear early in life. M.J. Buck, H.A. Durham,
A.R. Smither, B.G. Woods, E.L. Nickens, M.M. Lewis and
C.J. Lammi-Keefe. LSU, Pennington Biomed. Res. Ctr. and
LSU AgCtr.
D262 II1072.8Plasma
n-3/n-6
PUFAs
interact
with FADS2 genetic variations to affect blood cholesterol
concentrations in type 2 diabetes. M-C. Huang, P-C. Huang,
H-F. Chung and C-C. Hsu. Kaohsiung Med. Univ. and Natl.
Hlth. Res. Inst., Zhubnan, Taiwan.
D263 I1072.9Polyphenol supplementation ameliorates PUFA benefits in metabolic and oxidative status in dogs.
V.M. Leray, C. Talbot, K. Ouguerram, A-S. Martineau and P.
Nguyen. Oniris, Vet Sch. Nantes and U1089,INSERM, Nantes.
D264 II1072.10Vegans report less mood disturbance
than omnivores. B. Beezhold and J. Schiappa. Benedictine
Univ., IL.
D265 I1072.11
Effects of heated versus unheated
soybean oil in C57BL/6J mice. O. Middleton, N. Dingels and
M. Penumetcha. Georgia State Univ.
D266 II1072.12Erythrocyte
levels
of
omega-3
polyunsaturated fatty acids were negatively associated with
the risk of rheumatoid arthritis in Korean women. A. Lee and Y.
Park. Hanyang Univ., South Korea.
D267 I1072.13
Bone mechanical competence in
hypercholesterolemic rats fed MUFAn9 rich diets. E. Alsina,
C. Bozzini, E. Macri, F. Lifshitz, P. Rodriguez, P. Boyer and
S. Friedman. Sch. of Dent.. Univ. of Buenos Aires and Pediat.
Sunshine Acads. & Sansum Med. Res. Inst., Santa Barbara,
CA.
D268 II1072.14Low omega-3 fatty acid status in
residents of the Guatemalan Pacific Coastal Plain. R. Campos,
M.J. Soto-Méndez, E. Bailey, M. Detlefsen, K. Kraemer and
N. Salem. CeSSIAM, Guatemala City, DSM Nutr. Products
LLC, Columbia, MD, Cabcorp, Guatemala City and DSM Nutr.
Products Ltd., Kaiseraugst, Switzerland.
D269 I1072.15
Parenteral lipid minimization versus
composition for intestinal failure associated liver disease. J.K.
Josephson, P.W. Wales, P.N. Nation, P. Wizzard, D. Mager,
C.J. Field, R.O. Ball, P.B. Pencharz and J.M. Turner. Univ. of
Alberta and Univ. of Toronto.
D270 II1072.16Phospholipid PUFA: a better indicator
for assessing health risks. Y. Li, A.A. Friedman, Z. Yu, H.
Tamez, J. Wenger, R. Thadhani and B.A. Watkins. Univ. of
Connecticut, Indiana Univ. Sch. of Med. and Massachusetts
Gen. Hosp.
D271 I1072.17
Human milk fat globule proteinogenic
mRNA reveal existence of alternative transcripts. K.S.D.
Kothapalli, J.S. Zou, S.S. Hyon, K.E. Ojukwu, G.L. Bugbee,
R. Alluri, H.K. Park, J. Zhang, R.R. Ran-Ressler and J.T.
Brenna. Cornell Univ.
D272 II1072.18Baseline serum n-3 eicosapentaenoic
acid concentration is associated with subsequent mood
disturbance during the acute stress of military survival school
training. E.K. Farina, K. Grohmann, J.C. Biedenkapp, J.P.
McClung and H.R. Lieberman. U.S. Army Res. Inst. of Envrn.
Med., Natick, MA, Oak Ridge Inst. for Sci. and Educ., Belcamp,
MD and U.S. Army John F. Kennedy Spec. Warfare Ctr., Fort
Bragg, NC.
D273 I1072.19
Supplementation of omega 3 fatty
acids, vitamins and minerals has a moderating effect in the
behavior of typically developing adolescent schoolchildren in
the U.K.: a double blind placebo controlled trial. J. Tammam, D.
Steinsaltz, D.W. Bester, T. Semb and J. Stein. Oxford Univ.
D274 II1072.20Metabolic effects of bedtime pistachio
consumption for 6 weeks in overweight persons. A.D.
Anderson, M.M. Anderson, J.L. Jacobson, M.R. Popko, J.R.
Young, P.J. Limburg and T. Wilson. Winona State Univ. and
Mayo Clin.
D275 I1072.21
Omega-3 fatty acid intake patterns
in obese Southern women. K. Heidal, T. Goad, J. Cox, R.C.
Hickner and R.N. Cortright. Col. of Human Ecol. and Brody
Sch. of Med., East Carolina Univ.
1073.METABOLIC PHENOTYPING, METABOLOMICS
AND BIOMARKERS
Poster
Exhibit Halls A-B
D276 I1073.1Contrast ultrasound imaging of the
aorta does not affect progression of atherosclerosis in ApoE/mice. B.W. Smith, D.G. Simpson, S. Sarwate, R.J. Miller,
R.M. Abuhabsah, J.W. Erdman, Jr. and W.D. O’Brien, Jr.
Univ. of Illinois at Urbana-Champaign.
D277 II1073.2Effects of consuming oxidized vegetable
oils on tryptophan metabolism. L. Wang, D. Yao and C. Chen.
Univ. of Minnesota Twin Cities.
D278 I1073.32-Hydrazinoquinoline as a novel
derivatization
agent
for
LC-MS-based
metabolomic
investigation of streptozotocin-elicited ketoacidosis. Y. Lu, D.
Yao and C. Chen. Univ. of Minnesota, St.Ppaul.
D279 II1073.4Effect of an algal infusion on plasma
metabolomic profile in hypercholesterolemic hamsters. A.
Geamanu, N. Saadat, A. Goja and S.V. Gupta. Wayne State
Univ.
D280 I1073.5Investigation of metabolic adaptation
in developing chicken embryo and post-hatch chicks by blood
metabolomics. Q. Hu, U. Agarwal and B.J. Bequette. Univ. of
Maryland College Park.
D281 II1073.6Plasma amino acids as predictors for
outcome in patients at the intense care unit. B. Twelkmeyer,
P.C. Rodas, E. Skog-Nejman, J. Wernerman and O.
Rooyackers. Karolinska Univ. Hosp. Huddinge.
D282 I1073.7Plasma branch chain and aromatic
amino acid levels are associated with insulin resistance in
nonalcoholic fatty liver disease. N.E. Sunny, R. Lomonaco, R.
Petrocelli, U. Bashir, A. Egan and K. Cusi. Univ. of Florida.
D283 II1073.8A targeted lipidomic analysis of renal
oxylipins in kidney disease reveals differences in the effects of
dietary flax compared to fish oil. J.G. Devassy, T. Yamaguchi,
N. Ibrahim, A. Ravandi and H.M. Aukema. Univ. of Manitoba,
Canadian Ctr. for Agri-Food Res. in Hlth. and Med. and St.
Boniface Gen. Hosp. Res. Ctr., Winnipeg.
D284 I1073.9Calorie intake and blood lipidomics. B.
Kristal, V.S. Hubbard, P. Starke-Reed, S.S. Bird, V.R. Marur,
M. Sniatynski and D. Sheldon. Brigham and Women’s Hosp,
Harvard Med. Sch. and NIDDK, NIH.
359
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D285 II1073.10Perinatal
bisphenol
A
exposure
promotes hyperactivity with corresponding hormonal
responses. O.S. Anderson, K.E. Peterson, B.N. Sanchez, Z.
Zhang, P. Mancuso and D.C. Dolinoy. Univ. of Michigan.
D286 I1073.11
Impact of parenteral lipid emulsions
on the metabolomic phenotype in preterm TPN-fed piglets.
M.A. Kulkarni, H. Vlaardingerbroek, B. Stoll, O. Ilkayeva, C.
Newgard, O. Olutoye, J.B. Van Goudoever and D. Burrin.
Baylor Col. of Med., Erasmus MC-Sophia Children’s Hosp.,
Rotterdam, Duke Univ. Med. Ctr. and VU Univ. Med. Ctr.,
Amsterdam.
D287 II1073.12Targeted disruption of the nucleosomal
binding protein HMGN5 results in altered glutathione
metabolism and mild hepatic dysfunction. E.D. Ciappio, M.
Rochman, M. Horsch, J. Beckers, K.W. Krausz, J.A. Bonzo,
F.J. Gonzalez and M. Bustin. NCI, NIHand German Res. Ctr.
for Envrn. Hlth., Neuherberg.
D288 I1073.13
Metabolomics profiling predicts SORT1
LDL-cholesterol locus in a fit, young adult population. L.
Kirtiadi, E. Gnatiuk, A. Karlos, K. Connors, H.J. Vogel, J.
Shearer and D.S. Hittel. Univ. of Calgary, Canada.
D289 II1073.14Association of lead exposure and
untargeted metabolomics with BMI and hormones in
adolescence. K.E. Peterson, D. Dolinoy, C. Burant, J. Lee,
B. Sanchez, Z. Zhang, T.C. Yang, J. Goodrich, A. Ettinger,
J. Meeker, H. Hu, M. Solano, N. Wang and M.M. Tellez-Rojo.
Univ. of Michigan Sch. of Publ. Hlth., Univ. of Michigan Med.
Sch., Yale Sch. of Publ. Hlth., Univ. of Toronto, Natl. Inst. of Publ.
Hlth., Cuernavaca and Univ. of Michigan.
D290 I1073.15
Metabolomic profiling of the small for
gestational age piglet. C.M. Getty, A.A. Baratta and R.N.
Dilger. Univ. of Illinois, Urbana.
1074.CARBOHYDRATE METABOLISM
Poster
Exhibit Halls A-B
D291 I1074.1Acute human consumption of crystalline
short-chain amylose. Y-C. Shi, L.R. Brewer, C. Weber, L. Cai
and M.D. Haub. Kansas State Univ.
D292 II1074.2A standardized method for preparation
of potatoes and analysis of their resistant starch content:
variation by cooking method and service temperature. M.I.
Jackson, L.A. Idso, G.F. Combs, K. Beals and S.K. Raatz.
USDA, Grand Forks, Univ. of Utah and Univ. of Minnesota, St.
Paul.
D293 I1074.3Lactating mouse mammary gland
expresses secreted Mgam which enables unweaned suckling
pup starch digestion. B.L. Nichols, M. Diaz-Sotomayor, S.E.
Avery, D.L. Hadsell, L. Yan, B.R. Hamaker and R. QuezadaCalvillo. Baylor Col. of Med., Purdue Univ. and Autonomous
Univ. of San Luis Potosi, Mexico.
D294 II1074.4Chronic distal digesting of starch reduces
subsequent starch digestion through a post-translational
mechanism which reduces mucosal disaccharidase activities.
L. Yan, S.E. Avery, F.A. Vohra, S.K. Chacko, B.L. Nichols and
B.R. Hamaker. Purdue Univ. and Baylor Col. of Med.
360
D295 I1074.5Effects of fructose on uric acid
metabolism. F. Theytaz, L. Egli, Y. Cordero Rodriguez, V.
Campos, P. Schneiter and L. Tappy. Univ. of Lausanne.
D296 II1074.6Reduced glycemic response to starch
feeding of Mgam null mice is buffered by increased endogenous
gluconeogenesis. A.H-M. Lin, M. Diaz-Sotomayor, R.
Quezada-Calvillo, S.E. Avery, S.K. Chacko, L-k. Yan, Z-h.
Ao, B.R. Hamaker and B.L. Nichols. Purdue Univ. and USDA,
Baylor Col. of Med.
D297 I1074.7A randomized, crossover comparison of
the effects of high fructose corn syrup versus sucrose intake on
basic physiologic measures. E.M. Mouch, A.M. Walz, L. Tomaj
and J.W. Carbone. Eastern Michigan Univ. Sch. of Hlth. Sci.
D298 II1074.8Fructose
intake
and
circulating
triglycerides: an examination of the roles of APOC 3 and
FOXO1. E.S. Campbell and T.W. Castonguay. Univ. of
Maryland College Park.
D299 I1074.9Dairy snack reduces glycemia in normal
weight children. B. Gheller, M. McCormick, A. Li, Y. Anini, N.
Bellissimo, J. Hamilton, G.H. Anderson and B.L. Luhovyy.
Mount Saint Vincent Univ. and Dalhousie Univ., Halifax,
Ryerson Univ., Toronto and Univ. of Toronto.
D300 II1074.10Elevated gluconeogenesis in aging and
lung cancer is related to inflammation and blunted insulininduced protein anabolism. J. MacAdams, A. Winter, J.A.
Morais, S.C. Burgess and S. Chevalier. McGill Univ. and Univ.
of Texas Southwestern Med. Ctr.
D301 I1074.11
Effect of cinnamon on blood glucose,
satiety and caloric intake in middle-aged obese adults. J.C.
Chezem , S. Tickle, N. Fernandes and J.H. Bolin. Ball State
Univ.
D302 II1074.12Grain sorghum reduces plasma glucose
and insulin levels in healthy men. X. Gu, N. Poquette and S-O.
Lee. Univ. of Arkansas.
D303 I1074.13
Enzyme-synthesized highly branched
maltodextrins have slow glucogenesis at the mucosal
a-glucosidase level and are slowly digestible in vivo. B-H. Lee,
B.L. Nichols and B.R. Hamaker. Purdue Univeristy and Baylor
Col. of Med.
D304 II1074.14In vitro fermentation of various pectin
substrates by human fecal microbiota. B. Min, O-k. Koo, N.
Jarvis, P. Crandall, S. Ricke and S-o. Lee. Univ. of Arkansas.
1075.PROTEIN INTAKE AND HEALTH IMPLICATIONS
Poster
Exhibit Halls A-B
D305 I1075.1Casein and gluten-derived opiate
peptides affect cysteine uptake and redox status. J.J. Shah, M.
Trivedi, N. Hodgson and R. Deth. Northeastern Univ.
D306 II1075.2Plant and animal protein intakes are
differently associated with nutrient adequacy in French adults.
E.O. Verger, G.M. Camilleri, J-F. Huneau, F. Carpentier, C.
Dubuisson and F. Mariotti. AgroParisTech, Danone Res.,
Palaiseau and ANSES, Maisons-Alfort, France.
D307 I1075.3Meal consisting of egg white protein
yields higher satiety than an isocaloric wheat gluten protein
meal. K. Du, S. Adams and J.L. Beverly. Univ. of Illinois at
Urbana-Champaign.
TUESDAYNUTRITION
D308 II1075.4Effect of leucine supplementation on
lean body mass during prolonged hypoxic exposure for 13-day
trek to Everest Base Camp: a double-blind randomized study.
D.C. Gershenoff, S.L. Wing-Gaia, M.J. Drummond, P.F. Gaia
and E.W. Askew. Univ. of Utah.
D309 I1075.5Higher
protein
preterm
formula
increases weight gain. S. Simpson, T. Kennedy and R.
Larzelere. Oklahoma State Univ.
D310 II1075.6Dietary protein requirement of 65-75
year old females using indicator amino acid oxidation technique.
M. Rafii, G. Courtney-Martin, K. Chapman, J. Owens, R.
Elango, W.W. Campbell, R.O. Ball and P.B. Pencharz. The
Hosp. for Sick Children, Toronto, Univ. of British Colombia,
Purdue Univ. and Univ. of Alberta.
D311 I1075.7Effects of whey protein supplementation
on dietary compensation and muscle energetics in elderly
adults. K.L. Clark, K.A. Sands, S.P. McKenzie, J.M. Haddad,
S. Rietdyk and W.W. Campbell. Purdue Univ. and Indiana
Univ.-Purdue Univ. Indianapolis.
D312 II1075.8No difference in protein leverage
affecting energy intake between soy and whey protein. E.
Martens, S. Lemmens and M. Westerterp-Plantenga.
Maastricht Univ., Netherlands.
D313 I1075.9The impact of a protein-rich breakfast
on food cravings and reward in overweight/obese ‘breakfast
skipping’ adolescent girls. L.C. Ortinau, H.A. Hoertel, S.M.
Douglas and H.J. Leidy. Univ. of Missouri-Columbia.
D314 II1075.10Rice bran protein concentrate can
reduce fat accumulation in rats fed high-fat diet. J. Yu and O.
Lee. Yongin Univ., South Korea.
D315 I1075.11
Dietary protein intake, energy deficit,
and nitrogen balance in normal-weight adults: a randomized
controlled trial. L.M. Margolis, J.J. Cao, L.D. Whigham, J.P.
McClung, G.F. Combs, A.J. Young and S.M. Pasiakos. U.S.
Army Res. Inst. of Envrn. Med., Natick, MA and USDA, Grand
Forks.
D316 II1075.12Dietary protein requirement of 6575 year old adult males using indicator amino acid oxidation
technique. G. Courtney-Martin, M. Rafii, K. Chapman, R.
Elango, W.W. Campbell, R.O. Ball and P.B. Pencharz. The
Hosp. for Sick Children, Torontom British Columbia Children’s
Hosp., Purdue Univ. and Univ. of Alberta.
D317 I1075.13
Current intake of animal and vegetable
protein in the U.S.: What We Eat in America/National Health
and Nutrition Examination Survey, 2007-2010. V.L. Fulgoni III,
D.R. Keast, C.E. O’Neil and T.A. Nicklas. Nutr. Impact LLC,
Battle Creek, MI, Okemos, MI, LSU AgCtr. and USDA, Baylor
Col. of Med.
1076.SPORTS NUTRITION: DIETARY SUPPLEMENTS
AND HUMAN PERFORMANCE
Poster
Exhibit Halls A-B
D318 I1076.1The short-term effects of black pepper
(Piper nigrum) and rosemary (Rosmarinus officinalis) on
sustained attention and energy and fatigue mood states in
young adults with low energy. J.B. Lindheimer, B.D. Loy and
P.J. O’Connor. Univ. of Georgia.
D319 II1076.2Effect of Eurycoma longifolia on stress
hormones and psychological mood state in moderately
stressed subjects. S. Talbott, J. Talbott, A. George and M.
Pugh. SupplementWatch, Draper, UT, Biotropics Malaysia,
Kuala Lumpur and MonaVie, South Jordan, UT.
D320 I1076.3Effect of magnolia/phellodendron on
cortisol and mood state in moderately stressed subjects. S.
Talbott, J. Talbott and M. Pugh. SupplementWatch, Draper,
UT and MonaVie, South Jordan, UT.
D321 II1076.4Energy drink use in military populations:
an exploratory analysis. L.F. Delahanty, E. Jones, S. Attipoe,
P. Deuster, D. Jones and M. Stephens. Uniform Svc. Univ. of
Hlth. Sci.
D322 I1076.5HMB attenuates a loss of myofiber
cross-sectional area during prolonged exercise with calorie
restriction by enhancing regenerative capacity. B-S. Park, P.C.
Henning, A.V. Khamoui, E. Jo, S-R. Lee, M.C. Zourdos, D-H.
Kim, M-C. Yeh and J-S. Kim. Florida State Univ., U.S. Army
Res. Inst. of Envrn. Med., Natick, MA, Univ. of Memphis and
Florida Atlantic Univ.
D323 II1076.6Comparison of watermelon and
carbohydrate beverage on exercise-induced oxidative stress,
inflammation, and immune dysfunction, and augmentation
index. R.A. Shanely, D.C. Nieman, A.M. Knab, P. PerkinsVeazie, D. Henson, L. Cialdella-Kam, W. Sha and M.P.
Meaney. Appalachian State Univ., North Carolina State Univ.
and Univ. of North Carolina at Charlotte, Kannapolis.
D324 I1076.7A randomized double blind placebo
controlled evaluation of MSM for exercise-induced discomfort/
pain. D. Kalman, S. Feldman, A. Samson and D. Krieger.
Miami Res. Assocs.
D325 II1076.8Effects of a novel dietary supplement on
physical and mental function in middle-aged adults: a doubleblind, randomized, placebo-controlled trial. S.M. Wood, S.
Poole, M. Bartlett, A. Mastaloudis and D. Burke. Nu Skin
Enterprises, Provo, UT.
1077.B VITAMINS AND ONE-CARBON METABOLISM
Poster
(Sponsored by: Vitamins and Minerals RIS)
Exhibit Halls A-B
D326 I1077.1A comparison of American and
Canadian RBC folate concentrations. C.K. Colapinto, M.S.
Tremblay, S. Aufreiter, T. Bushnik, C.M. Pfeiffer and D.L.
O’Connor. Children’s Hosp. of Eastern Ontario Res. Inst., The
Hosp. for Sick Children, Toronto Stats. Canada, Ottawa and
Ctrs. for Dis. Control and Prevent.
D327 II1077.2Folate in human skin: its correlation with
serum levels, and the unusual abundance in the epidermis
of 5-methyl-tetrahydrofolate. L.Z. Hasoun, S.W. Bailey, K.K.
Outlaw and J.E. Ayling. Univ. of South Alabama and Mobile
Infirmary.
D328 I1077.3A
comprehensive
list
of
sociodemographic, dietary and lifestyle factors has limited
predictive power in determining RBC folate concentrations
maximally protective against neural tube defects. B. Hartman,
A.J. Hanley, S. Aufreiter, C.K. Colapinto, M.S. Tremblay
and D.L. O’Connor. Univ. of Toronto and Children’s Hosp. of
Eastern Ontario, Ottawa.
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D329 II1077.4Comparison study between RBC
folate measured by microbiologic assay and Immulite 2000
immunoassay. S. Aufreiter, C.K. Colapinto, M.S. Tremblay,
T. Bushnik, C.M. Pfeiffer and D.L. O’Connor. The Hosp. for
Sick Children, Toronto, Children’s Hosp. of Eastern Ontario,
Ottawa, Statistics Canada, Ottawa and Ctrs. for Dis. Control
and Prevent.
D330 I1077.5Perturbed 1-carbon metabolism alters
bile acid pools and insulin signaling. K.D. Corbin, S. Mei, W.
Cao and S.H. Zeisel. Univ. of North Carolina at Chapel Hill,
Kannapolis and Gillings Sch. of Global Publ. Hlth., Chapel Hill.
D331 II1077.6Dietary intake and major food sources of
vitamin B6 in Korean adults. Y-N. Kim and Y-O. Cho. Duksung
Women’s Univ., South Korea.
D332 I1077.7Choline modulates soluble-endoglin
and vascular endothelial growth factor in cultured human
placental trophoblasts. B.Y. Andrew, X. Jiang, S. Jones, M.A.
Caudill and P.M. Brannon. Cornell Univ.
D333 II1077.8Folate
deficiency
accelerates
Alzheimer’s disease related pathology in APP/PS1 mice.
N. Crivello, T. Spires-Jones, B. Shukitt-Hale, A. Carey,
A. Roe, D. Smith, J. Krzysztof Blusztajn, B. Hyman and I.
Rosenberg. USDA at Tufts Univ., Massachusetts Gen. Hosp./
Harvard Med. Sch., Charlestown and Boston Univ. Sch. of Med.
D334 I1077.9Influence of lactation and choline
intake on one-carbon biomarkers in women. C. Davenport, K.
Shields, J. Yan, X. Jiang, O. Malysheva, M. Caudill, S. Stabler
and R. Allen. Cornell Univ. and Univ. of Colorado Denver.
D335 II1077.10Response of vitamin B12 status to a
controlled B12 intake in nonpregnant, pregnant, and lactating
women. S. Bae, A.A. West, J. Yan, X. Jiang, C.A. Perry and
M.A. Caudill. Cornell Univ.
D336 I1077.11
Fortifying whole wheat flour with folic
acid does not change the prevalence of folate inadequacy nor
the percentage of Canadians with intakes above the tolerable
upper intake level. Y-M. Chan, A. MacFarlane and D.L.
O’Connor. Univ. of Toronto and Hlth. Canada, Ottawa.
D337 II1077.12Genetic
C677T
polymorphisms
of methylenetetrahydrofolate reductase and one-carbon
metabolites as prognostic predictors for survival outcome of
patients with hepatocellular carcinoma. C.S. Kuo, C-Y. Hwung,
S-D. Kuo, C-P. Cheng, C-H. Chen, C-L. Lu and R-F. Huang.
Fu Jen Univ., New Taipei City, Chi-Mei Med. Ctr., Tainan and
Natl. Taiwan Univ. Hosp. and Col. of Med.
D338 I1077.13
Uracil accumulation induced by folate
depletion is dependent on uracil DNA glycosylase activity. H.
Ma, Y. Wu, K. Simon, A. Ahmed and D.C. Cabelof. Wayne
State Univ.
D339 II1077.14Pregnancy increases the use of cholinederived methyl groups for phosphatidylcholine production
through the PEMT pathway with subsequent selective transfer
of PEMT-PC to the fetus. J. Yan, A.A. West, X. Jiang, C.A.
Perry, O.V. Malysheva and M.A. Caudill. Cornell Univ. and
Shepherd Univ., WV.
D340 I1077.15
The effect of fruits and vegetables in the
elevated plasma homocysteine: experience of using a quantile
regression approach. J. Steluti, E. Verly, Jr., R.M. Fisberg and
D.M.L. Marchioni. Sch. of Publ. Hlth., Univ. of São Paulo and
Inst. of Soc. Med., Rio de Janeiro State Univ.
362
D341 II1077.16Relationship between leukocyte global
DNA methylation and RBC folate in the Women’s Health
Initiative Observational Study. S. Bae, M.A. Caudill, L.B. Bailey,
O. Malysheva, J.W. Miller, E.C. Brown, M.L. Neuhouser, D.
Maneval, T-Y.D. Cheng, L. Hou, S.A.A. Beresford, X. Song,
Y. Zheng, K. Buck and C.M. Ulrich. Cornell Univ., Univ. of
Georgia, Rutgers Univ., Fred Hutchinson Cancer Res. Ctr.,
Univ. of Florida, Northwestern Univ., Chicago and German
Cancer Res. Ctr., Heidelberg.
D342 I1077.17
Low-dose
methotrexate
inhibits
methionine S-adenosyltransferase in vitro and in vivo. Y-C.
Wang and E-P. Chiang. Natl. Chung Hsing Univ., Taiwan.
D343 II1077.18Detectable levels of unmetabolized folic
acid in Canadian pregnant women. L. Plumptre, S. Masih, A.
Ly, S. Aufreiter, R. Croxford, A.Y. Lausman, H. Berger, D.L.
O’Connor and Y-I. Kim. Univ. of Toronto, St. Michael’s Hosp.
and The Hosp. for Sick Children, Toronto.
D344 I1077.19
Dietary vitamin B6 intake modulates
colonic inflammation in the IL-10-/- model of inflammatory bowel
disease. J. Selhub, A. Byun, Z. Liu, J.B. Mason, R.T. Broson
and J.W. Crott. USDA at Tufts Univ., Univ. of Massachusetts
Amherst and Harvard Med. Sch.
D345 II1077.20B-vitamins influence arsenic metabolism
in Mexico. M.A. Mendez, R. Vavolizza, M.C. GonzalezHorta, J. Saunders, D. Gutiérrez-Torres, M.L. Ballinas
Casarrubias, B.E. Sánchez-Ramírez, M.C. Ishida, L.M. Del
Razo, G. García-Vargas, Z. Drobná, J. Buse, D. Loomis and
M. Styblo. Univ. of North Carolina at Chapel Hill, Autonomous
Univ. of Chihuahua, Mexico, Univ. Juárez del Estado de
Durango, Mexico and IARC, Lyon, France.
D346 I1077.21
Anthranilic acid and 3-hydroxyanthranilic
acid, but not kynurenic acid, are associated with plasma
pyridoxal-5 phosphate levels. C.D. Reginaldo, J. Selhub, L.
Paul, P. Jacques, T. Wang and R. Gerszten. Friedman Sch. of
Nutr. Sci. and Policy and USDA at Tufts Univ. and Massachusetts
Gen. Hosp., Harvard Med. Sch.
D347 II1077.22Methylmalonic acid concentration in
dried blood spots – validation of a novel method for vitamin
B12 status assessment. T.H. Schroder, T.A.W. Quay and Y.
Lamers. Univ. of British Columbia.
D348 I1077.23
Effects of vitamin B6 on one-carbon
metabolism in oral contraceptive users. L. Rios-Avila, M.
Ralat, B. Coats, P.W. Stacpoole and J.F. Gregory. Univ. of
Florida Col. of Med.
D349 II1077.24The effects of folate, choline and betaine
on transmethylation in a methionine-restricted piglet. J.L.
Robinson, L.E. McBreairty, J.A. Brunton and R.F. Bertolo.
Mem. Univ. of Newfoundland, Canada.
D350 I1077.25
Folic acid supplementation for 12 weeks
modifies gene expression in leukocytes in men with low folate
status. L. Paul, C. Razzari, F. Sampietro, G. Fontana, I. Fermo,
C. Reginaldo, M. Cattaneo, A. D’Angelo, P.F. Jacques and J.
Selhub. USDA at Tufts Univ., Hosp. San Paolo, Univ. of Milan
and Sci. Inst. San Raffaele, Milan.
D351 II1077.26Cellular
pyridoxal
phosphate
concentration influences amino acid profiles and presence
of hydrogen sulfide biomarkers in cultured HepG2 cells. B.N.
DeRatt, M. Ralat, O. Kabil, R. Banerjee and J.F. Gregory.
Univ. of Florida and Univ. of Michigan Med. Sch.
D352 I1077.27
Paternal folate deficiency influences
hepatic DNA methylation, IGF-1, IGF-2 and IGF-1R expression
in the rat pup. K.K.R. Mejos, E.M. Lim, H.W. Kim and N.
Chang. Ewha Womans Univ., South Korea.
TUESDAYNUTRITION
1078.CARDIOVASCULAR EFFECTS OF DIETARY
BIOACTIVE COMPONENTS
Poster
(Sponsored by: Dietary Bioactive Components RIS)
Exhibit Halls A-B
D353 I1078.1Effects of low-fat dairy intake on
blood pressure and endothelial function in subjects with
pre-hypertension or stage I hypertension. K. Maki, T. Rains,
A. Schild, M. Dicklin, A. Lawless, K. Kelley and K. Park.
Biofortis Clin. Res., Addison, IL and Dairy Res. Inst./Natl. Dairy
Council, Rosemont, IL.
D354 II1078.2Effects of walnuts on vascular function
and platelet reactivity in postmenopausal women with
hypercholesterolemia. S.J. Yim, D. Djurica, R.R. Holt, C.L.
Keen and R.M. Hackman. Univ. of California, Davis.
D355 I1078.3Manganese supplementation reduces
monocyte adhesion to endothelial cells by reducing ROS and
downregulating ICAM-1 independently of MnSOD. E. Burlet
and S.K. Jain. LSU Hlth.- Shreveport.
D356 II1078.4Assessment of folate, vitamin B6 and
vitamin B12 status among newly diagnosed Omani cardiac
patients. M.I. Waly, A. Ali, Y.M. Al-Farsi, A. Ouhtit, A. AlNassri and M. Arafa. Sultan Qaboos Univ., Oman, Alexandria
Univ., Egypt and King Saud Univ., Saudi Arabia.
D357 I1078.5Low-fat
dairy
intake
improves
endothelial function in subjects with pre-hypertension or stage
I hypertension and impaired endothelial dysfunction. K. Maki,
T. Rains, A. Schild, M. Dicklin, A. Lawless, K. Kelley and K.
Park. Biofortis Clin. Res., Addison, IL and Natl. Dairy Council,
Rosemont, IL.
D358 II1078.6Wild blueberry-enriched diet affects a1adrenergic induced vasoconstrictor response in the aorta of
obese Zucker rats. S. Vendrame, A.S. Kristo, A. Daugherty,
D.A. Schuschke and D. Klimis-Zacas. Univ. of Maine and
Univ. of Louisville Sch. of Med.
D359 I1078.7Physiological responses to caffeine
are moderated by sex and pubertal phase. A.M. Ziegler, A.
Graczyk, A. Bendlin, K. Vattana, T. Sion, S. O’Leary and J.L.
Temple. Univ. at Buffalo.
D360 II1078.8Regulation of genes involved intestinal
cholesterol metabolism by polyphenol-rich black currant
extract in Caco-2 cells. B. Kim, A. Perkins and J. Lee. Univ. of
Connecticut.
D361 I1078.9Effect of rosemary supplementation
on oxidative stress after myocardial infarction in rats. B.P.M.
Rafacho, P.P. dos Santos, A.F. Gonçalves, R. Candido,
A.A.H. Fernandes, P.A. Schmidt, L.A.M. Zornoff, Á.O.
Campana, M.F. Minicucci and S.A.R. Paiva. São Paulo State
Univ., Bauru and Botucatu.
D362 II1078.10Effect of a flavonoid-rich cacao extract
on vascular reactivity in a mouse model. K.G. CastilloHernández, M.C. Castillo-Hernández, G. Guevara-Balcázar
and R.M. Coral-Vázquez. Grad. Sch. of Med., Natl Polytech
Inst., Mexico City.
D363 I1078.11
Barley
beta-glucan
consumption
decreases serum cholesterol level and increases 7 alphahydroxy-4-cholesten-3-one level in hypercholesterolemic
adults. Y. Wang, S.E. Harding, S.M. Tosh, P.J. Jones and N.P.
Ames. Univ. of Manitoba, Cereal Res. Ctr., Winnipeg, King’s
Col. London, Guelph Food Res. Ctr. and Richardson Ctr. for
Funct. Foods and Nutraceuts., Winnipeg.
D364 II1078.12Comparison of hypolipidemic effects of
three berries in diet-induced obese C57BL6J mice. B. Kim,
S.G. Lee, C.S. Ku, Y. Park, Y. Yang, T.X. Pham, C. Wegner, S.I.
Koo, O.K. Chun and J. Lee. Univ. of Connecticut.
D365 I1078.13
Effects of polyphenolic-rich dark
chocolate/cocoa and almonds on established and emerging
cardiovascular risk factors: study design. C.E. Berryman,
S.G. West, C-Y.O. Chen, J.B. Blumberg, J.A. Fleming, A.G.
Preston, D.L. Miller and P.M. Kris-Etherton. Penn State,
USDA at Tufts Univ. and The Hershey Co.
D366 II1078.14Consuming 12 eggs per week for 1
year does not alter serum lipids, lipoprotein cholesterol, or
C-reactive protein in older adults. T.A. Wilson, H. Aljohi, E.
Kotyla and M.D. Nelson. Univ. of Massachusetts Lowell.
D367 I1078.15
Effect of vitamin D on ROS, ICAM-1
and monocyte adhesion in human umbilical vein endothelial
cells treated with high glucose and acetoacetate. P. KanikarlaMarie and S.K. Jain. LSU Hlth. Sci. Ctr., Shreveport.
D368 II1078.16Effects of milk and carbonated beverage
consumption on ambulatory blood pressure and cardiovascular
responses to stress: a pilot study. S.A. Kynast-Gales, E.C.
Johnson and L.K. Massey. Washington State Univ.
1079.DIETARY BIOACTIVE COMPONENTS OF
MEDICINAL, FUNCTIONAL AND WHOLE FOODS
(INCLUDING PROBIOTICS AND FERMENTED
FOODS)
Poster
(Sponsored by: Dietary Bioactive Components RIS)
Exhibit Halls A-B
D369 I1079.1Pooled analysis of impact of Lycium
barbarum fruit (goji) intake on central adiposity, sleep quality
and general well-being: randomized, double-blind, placebocontrolled human clinical studies. H. Amagase, C-H. Hsu and
D.M. Nance. FreeLife Intl., Phoenix, Univ. of Arizona Col. of
Publ. Hlth. and Univ. of California Irvine, Orange.
D370 II1079.2Sorghum extracts reduced hepatic
cholesterol biosynthesis in mice fed high cholesterol diet. S.H.
Kim and Y. Park. Hanyang Univ., South Korea.
D371 I1079.3Effects of dietary fiber on body
mass index: a systematic review of cross-sectional studies,
prospective cohort studies and randomized controlled trials. R.
Korczak and J.L. Slavin. Univ. of Minnesota, St. Paul.
D372 II1079.4The efficacy of some common
vegetables in ameliorating the impact of cement dust selected
enzymes in wild and laboratory rats. J.E. Okpuzor and Y.
Tajudeen. Univ. of Lagos, Nigeria.
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D373 I1079.5Differential capability of Korean soybean
varieties to biosynthesize glyceollins. J-S. Kim, I.S. Park, H.J.
Kim, J.Y. Seo, S.S. Kim, B.R. Kim, A. Zakharova and H.R.
Kang. Sch. of Applied Biosci., Kyungpook Natl. Univ., South
Korea.
D374 II1079.6The p53-dependent elevation of human
colon cancer stem cell apoptosis by Java plum anthocyanins.
V.R. Charepalli, L. Reddivari and J. Vanamala. Colorado
State Univ.
D375 I1079.7Antidiabetic effects and antioxidant
capacity of polyphenol-enhanced Rutgers scarlet lettuce. D.M.
Cheng, N. Pogrebnyak, A. Poulev, P. Kuhn, C.G. Krueger,
C. Waterman and I. Raskin. Rutgers Univ. and Complete
Phytochem. Solutions LLC, Cambridge, WI.
D376 II1079.8Anti-stress effect of enzyme-treated
asparagus extract (ETAS). S. Kudo, A. Sato, T. Ito, K. Homma
and H. Nishioka. Amino Up Chem. Co. Ltd., Sapporo.
D377 I1079.9Wheat bran for colon cancer prevention:
phytochemicals versus fiber. S. Sang, Y. Zhu and D.N. Soroka.
North Carolina A&T State Univ.
D378 II1079.10Hypocholesterolemic
effect
of
hexacosanol in HepG2 cells and C57BL6 mice. J.H. Lee, Y.
Kim, W-D. Seo and S-J. Lee. Col. of Life Sci. and Biotechnol,
Korea Univ. and Natl. Inst. of Crop Sci., Miryang, South Korea.
D379 I1079.11
Baked purple potato extracts, containing
anthocyanins, elevate apoptosis in colon cancer stem cells via
p53 independent pathways. J. Vanamala, V. Charepalli and L.
Reddivari. Colorado State Univ.
D380 II1079.12Health and functional characteristics of
indigenous food in the Korean longevity belt. M.S. Lee and K-H.
Moon. Hannam Univ. and Sunchang Inst. of Hlth. & Longevity,
South Korea.
D381 I1079.13
Changes in RAPD molecular marker
polymorphism during Cordyceps sinensis maturation. L. Gao,
Y-S. Yao, Z. Wu and J-S. Zhu. Pharmanex Beijing Pharmacol.
Ctr., NS Ctr. for Anti-Aging Res., Provo, UT and Hong Kong
Polytech Univ.
D382 II1079.14Standardized chungkookjang, shortterm fermented soybeans with Bacillus lichemiformis, improves
cognitive function and insulin resistance in b-amyloid-infused
diabetic rats. S. Park, S. Kang, H.J. Kim, D.Y. Kwon and J.
Daily. Hoseo Univ. and Korean Food Res. Insts., South Korea
and Daily Manufacturing Inc., Rockwell, NC.
D383 I1079.15
Evaluation of long-chain n3 fatty acid
content in diploid and triploid rainbow trout. M.J. Picklo, S.K.
Raatz, B. Cleveland and C. Rexroad III. USDA, Grand Forks
and Natl. Ctr. for Cool and Cold Water Aquacult., Kearneysville,
WV.
D384 II1079.16Isolation
of
anti-obesity
active
compound orientin from Lythrum salicaria L. H.Y. Kim, K.Y.
Lee, S-Y. Hong, S.H. Lim, K.H. Kim and S. Kim. Gangwondo
Agr. Res. and Ext. Svcs., Chuncheon-si and Kangwon Natl.
Univ., South Korea.
D385 I1079.17
L. reuteri NCIMB 30242: the sunshine
probiotic? M.L. Jones, C.J. Martoni and S. Prakash. McGill
Univ. and Micropharma Ltd., Montreal.
D386 II1079.18Immunostimulatory effects of Curcuma
longa L. mulberry leaves, and purple sweet potato extracts :
modulation of immune functions during murine leukemia virus
infection. S-A. Yoo, O-K. Kim, D-E. Nam, S-J. Park, D-K. Han,
H-O. Kwon and J. Lee. Kyung Hee Univ., South Korea.
D387 I1079.19
Polyphenolic content of sweet dried
cranberries compared to cranberry juice cocktail. J. Marais
and C. Khoo. Ocean Spray Cranberries Inc., Lakeville, MA.
364
D388 II1079.20L. reuteri NCIMB 30242: a probiotic with
benefits. M.L. Jones, C.J. Martoni and S. Prakash. McGill
Univ. and Micropharma, Montreal.
D389 I1079.21
Bioactive compounds and antioxidant
property of Korean traditional tea. H-R. Yang, Y-J. Yi, J-S. Park,
H-B. Jo, J-H. Kim and Y-Z. Chae. Seoul Metro. Govt. Res. Inst.
of Publ. Hlth. and Envrn.
D390 II1079.22Effects of the sea tangle-added patty
on postprandial blood glucose and lipid profiles in borderlinehyperlipidemic adults. H-S. Lim and H-H. Kim. Chonnam Natl.
Univ., South Korea.
D391 I1079.23
Analysis of coenzyme Q10 in marine oil
supplements. C. Scholl, J. Dever and D. Barnes. Standard
Process Inc., Palmyra, WI.
D392 II1079.24Sweet potato cultivar flesh color and
compositional effects on glycemic index. J.C. Allen, W. Sun
and V.D. Truong. North Carolina State Univ. and USDA,
Raleigh.
D393 I1079.25
Identification
of
resveratrol-3-bglucoside in Clifornia almond varieties. L. Xie and B. Bolling.
Univ. of Connecticut.
D394 II1079.26Changes in the metagenome and
plasma lipids of hamsters fed high fat diets containing
Chardonnay grape seed flour. H. Kim, T. Arvik, R. Lipson,
G.E. Bartley, D-H. Kim, K. Seo and W. Yokoyama. Univ. of
California, Davis, Sonomaceuts., Santa Rosa, CA, USDA,
Albany, CA and Konkuk Univ., South Korea.
D395 I1079.27
Fatty acid and phytosterol profiles of
commercial saw palmetto supplements. K. Penugonda and
B.L. Lindshield. Kansas State Univ.
D396 II1079.28Fucosterol, a liver X receptors agonist,
stimulates RCT and regulates the expression of key genes in
cholesterol homeostasis in vitro. H. Minh Hien and S-J. Lee.
Col. of Life Sci. and Biotechnol., Korea Univ.
D397 I1079.29
Seanol® and its major compound,
dieckol suppress lipid accumulation during adipogenesis
through inhibition of mitotic clonal expansion and cell cycle
arrest. H-S. Choi, H-J. Jeon, O-H. Lee and B-Y. Lee. CHA
Univ. and Kangwon Natl. Univ., South Korea.
D398 II1079.30Effects of phytosterols and fatty acids
from lotus (Nelumbo nucifera) seed on differentiation of human
preadipocytes into adipocytes. S.H. Kim, X. Zhao, J. Shen and
K.J. Chang. Konkuk Univ. and Inha Univ., South Korea.
D399 I1079.31
A solute carrier protein, the mammalian
flavonoid transporter, mediates cellular flavonoid uptake. J.H.
Lee, Y. Kim and S-J. Lee. Col. of Life Sci. and Biotechnol.,
Korea Univ.
D400 II1079.32Sweet potato skin provides health
benefits in Caenorhabditis elegans model. C. Gao, M. King,
J. Finley, F. Greenway, M. Keenan, F. Enright, R. Martin, W.
Johnson and J. Zheng. LSU AgCtr. and Pennington Biomed.
Res. Ctr.
D401 I1079.33
Kaempferia galanga L. suppresses
melanin synthesis through inhibition of the CREB/MITF in B16
cells. B-K. Jeon, Y-J. Mun, W-H. Woo and Y-E. Lee. Wonkwang
Univ., South Korea.
D402 II1079.34Supercritical fluid extraction of antiinflammatory polyacetylenes from celeriac (Apium graveolens
L.). B.T. Metzger, J.C. Waksmonski, A.L. Thompson and
D.M. Barnes. Standard Process Inc., Palmyra, WI.
D403 I1079.35
Comparison and purification of grape
pomace extracts for inhibition of intestinal a-glucosidases. H.C.
Kadouh, S. Sun and K. Zhou. Wayne State Univ.
TUESDAYNUTRITION
D404 II1079.36Characterization and quantitation of
bioactive compounds in date fruit seed using UPLC-DAD-ESIMS. H. Habib, C. Platat and W. Ibrahim. United Arab Emirates
Univ.
D405 I1079.37
Bioactive micronutrients in rice varieties
and their extraction efficiency. I.O. Minatel, G. Aldini, M.
Colzani, S-I. Han, C.R. Correa, D. Fecchio and K-J. Yeum.
USDA at Tufts Univ., São Paulo State Univ., Botucatu Med.
Sch., Univ. of Milan and Natl. Inst. of Crop Sci., RDA, Miryang,
South Korea.
D406 II1079.38A flavonoid-rich apple extract inhibits
growth of HCT116 human colon cancer cells. A. Morton, L.
Cao and L.D. Bourquin. Michigan State Univ.
D407 I1079.39
Padiococcus acidilactici isolated from
traditional Makgeolli inhibits lipid accumulation in 3T3-L1
adipocyte and obesity in C57BL6J mice fed a high-fat diet. Y-J.
Moon, S-H. Baik and Y-S. Cha. Chonbuk Natl. Univ., South
Korea.
D408 II1079.40Anti-obesity effect of GTF extracts in
high fat diet-induced obesity mice. S. Park, O-K. Kim, D-E.
Nam, J-N. Ho, S-A. Yoo, D-K. Han, H-ol. Kwon and J. Lee.
Kyung Hee Univ., South Korea.
D409 I1079.41
Effect of storage temperature on the
stability of fat-soluble micronutrients in rice varieties. I.O.
Minatel, D.T. Pierine, S-I. Han, C.R. Correa, D. Fecchio and
K-J. Yeum. USDA at Tufts Univ., Botucatu Med. Sch., State
Univ. of São Paulo and Natl. Inst. of Crop Sci., RDA, Miryang,
South Korea.
D410 II1079.42Ex vivo anti-adhesion activity of a
proanthocyanidin standardized cranberry powder beverage.
K.L. Kaspar, A.B. Howell and C. Khoo. Ocean Spray
Cranberries Inc., Lakeville, MA and Rutgers, The State Univ. of
New Jersey, Chatsworth.
D411 I1079.43
Acute toxicity of lotus (Nelumbo
nucifera) seed ethanol extract in ICR mice. J.S. You, S.H. Kim,
Y.J. Lee, S.Y. Kim, X. Zhao and K.J. Chang. Inha Univ. and
Konkuk Univ., South Korea.
D412 II1079.44Single dose oral toxicity of the lotus
(Nelumbo nucifera) root ethanol extract in ICR mice. J.S. You,
S.H. Kim, Y.J. Lee, S.Y. Kim, X. Zhao and K.J. Chang. Inha
Univ. and Konkuk Univ., South Korea.
D413 I1079.45
Serum-derived bovine immunoglobulin
isolate as a potential therapy for inflammatory bowel disorders.
G.L. Klein, E. Weaver, A.L. Shaw and J. Cohn. Entera Hlth.
Inc. and Tab Clin. Trials Inc., Cary, NC.
D414 II1079.46The natural carotenoid astaxanthin,
a PPAR modulator, ameliorates hepatic steatosis in C57BL6
mice. Y. Jia and S-J. Lee. Grad. Sch. of Biotechnol. and Col. of
Life Sci. and Biotechnol., Korea Univ.
D415 I1079.47
In vitro inhibition of dipeptidyl peptidase
IV by amaranth peptides. A.J. Velarde-Salcedo, S. LaraGonzález, G.M. Monero-Morán, E. Gonzalez de Mejia and
A.P. Barba de la Rosa. IPICyT, San Luis Potosi, Mexico and
Univ. of Illinois, Urbana.
D416 II1079.48NIH/ODS Analytical Methods and
Reference Materials Program: accomplishments and future
directions. J.M. Betz, L.G. Saldanha, G.L. Cragg, B.C. Sorkin
and P.M. Coates. ODS, NIH.
D417 I1079.49
Protective effect of GSW against UVBinduced skin damage. O-K. Kim, J-N. Ho, D-E. Nam and J.
Lee. Kyung Hee Univ., South Korea.
D418 II1079.50The dipeptide H-Trp-Glu-OH shows
agonistic activity to PPAR-a, reducing hepatic lipid accumulation
in lipid-loaded H4IIE cells. Y. Jia and S-J. Lee. Col. of Life Sci.
and Biotechnol., Korea Univ.
D419 I1079.51
Anti-obesity effects of Cheonggukjang
and Natto extract: from in vivo to in vitro study. C-B. Bae, M-S.
Byun, O-K. Yu, T-S. Park and Y-S. Cha. Chonbuk Natl. Univ.,
South Korea.
D420 II1079.52Effect of replacing of pork fat with barley
flour in reduced-fat sausage on cholesterol concentrations in
C57BL6J mice. H. Minh Hien and S-J. Lee. Col. of Life Sci.
and Biotechnol., Korea Univ.
D421 I1079.53
Fermented barley averts diet-induced
obesity via modulating the lipid metabolic gene expression in
Sprague Dawley rats. P.B.T. Pichiah, H-J. Moon, Y-J. Moon
and Y-S. Cha. Chonbuk Natl. Univ., South Korea.
D422 II1079.54Biological activities of water-soluble
sulfated polysaccharides from Ecklonia cava, Enteromorpha
prolifera and Monostroma nitidum. H. Minh Hien , J-Y. Kim
and S-J. Lee. Col. of Life Sci. and Biotechnol., Korea Univ.
D423 I1079.55
Baicalein inhibits lipid accumulation
through regulation of MCE and cell cycle during 3T3-L1
adipocyte differentiation. M-J. Seo, H-S. Choi, O-H. Lee and
B-Y. Lee. CHA Univ. and Kangwon Natl. Univ., South Korea.
D424 II1079.56Therapeutic effect of daily vinegar
ingestion for individuals at risk for type 2 diabetes. C.S.
Johnston, S. Quagliano and S. Loeb. Arizona State Univ.
D425 I1079.57
Suppression of TPA-induced invasion of
HepG2 cells by glyceollins. J-S. Kim, I.S. Park, H.J. Kim, S.S.
Kim, H.R. Kang, B.R. Kim, A. Zakharova and J.Y. Seo. Schs.
of Applied Biosci. and Food Sci. and Biotechnol., Kyungpook
D426 II1079.58Endotoxin neutralization activity of
bovine plasma and bovine immunoglobulin (IgG)-rich fractions
as compared to human plasma. E.M. Weaver, G.L. Klein, B.K.
DeVries, K. Maas and A.L. Shaw. Entera Hlth. Inc., Ankeny, IA
and Cary, NC.
D427 I1079.59
Effects of a high fat/high fructose
diet on brain mitochondria are counteracted by cinnamon in
stressed rats. C. Batandier, L. Poulet, F. Canini, K. Couturier,
I. Hininger-Favier, R.A. Anderson and A-M. Roussel. Univ.
Joseph Fourier, Grenoble, Army Res. Ctr., La Tronche, France
and USDA, Beltsville.
D428 II1079.60Evaluation of pumpkins as a novel
source for a-carotene. M. Kemp, J. Dever, A. Thompson, B.
Metzger and D. Barnes. Standard Process, Palmyra, WI.
D429 I1079.61
Systematic review of wild rice: an
ancient grain with modern benefits. D.A. Timm and J. Slavin.
Univ. of Minnesota-Twin Cities.
D430 II1079.62Inhibitory effect of Canavalia gladiata
extract on gastric inflammation induced by acute ethanol
treatment in SD rats. O.K. Kim, J-N. Ho, D-A. Nam and J. Lee.
Kyung Hee Univ., South Korea.
D431 I1079.63
Effect of a Korean, 2010 Dietary
Guidelines for Americans, and typical American diet on fecal
microbiota composition of overweight adults. G.I. SolanoAguilar, M. Kang, N. Schroeder, S. Lakshman, B. Vinyard,
G. Ha, Y. Kim, Y. Park, H. Kim, A. Yates and B. Caballero.
USDA, Beltsville, Natl. Acad. of Agr. Sci., Suwon, South Korea
and Johns Hopkins Univ.
365
T
U
E
NUTRITIONTUESDAY
D432 II1079.64Measurement of the whole blood
transcriptomic signatures in healthy elderly subjects fed the
probiotic bacteria Lactobacillus rhamnosus GG ATCC 53103
(LGG). G.I. Solano-Aguilar, A. Molokin, C. Botelho, A-M.
Fiorino, C. Chen, J. Urban, H. Dawson, M. Haverkamp, L.
Wang and P. Hibberd. USDA, Beltsville and Massachusetts
Gen. Hosp. for Children.
D433 I1079.65
Glucosamine sulfate attenuates dextran
sodium sulfate induced colitis in mice. Y-K. Bak, J.W. Lampe
and M-K. Sung. Sookmyung Women’s Univ., South Korea and
Fred Hutchinson Cancer Res. Ctr.
1080.NUTRIENT CONTROL OF PROTEOMICS AND
METABOLOMICS
Poster
(Sponsored by: Nutrient-Gene Interactions RIS)
Exhibit Halls A-B
D434 I1080.1Dietary C20-22 w3 PUFA regulate
hepatic oxidized PUFA levels and attenuate markers of dietinduced non-alcoholic steatohepatitis in Ldlr-/- mice. C.M.
Depner, K.M. Bohren, E. Morin-Kensicki and D.B. Jump.
Oregon State Univ., USDA, Baylor Col. of Med. and Metabolon
Inc., Durham, NC.
D435 II1080.2Vitamin D status impacts serum
metabolomic profiles in pregnant adolescents. J.L. Finkelstein,
E.K. Pressman, E.M. Cooper, T.R. Kent and K.O. O’Brien.
Cornell Univ. and Univ. of Rochester Med. Ctr.
D436 I1080.3Caffeine intake and the plasma
proteome. O. Tian, A.R. Josse and A. El-Sohemy. Univ. of
Toronto.
D437 II1080.4A genome-wide association study of
the human plasma proteome. J. Jamnik, B. Garcia-Bailo, C.
Borchers and A. El-Sohemy. Univ. of Toronto and Univ. of
Victoria, Canada.
D438 I1080.5Hyperglycemia mediates a shift from
cap-dependent to cap-independent mRNA translation through
a 4E-BP1 dependent mechanism. M.D. Dennis, S.R. Kimball
and L.S. Jefferson. Penn State Col. of Med.
D439 II1080.6Lower plasma DHA and EPA and their
related oxylipins are potential contributors to vascular disease
in hemodialysis patients. B.A. Watkins, J. Kim, S. Kaiser, A.N.
Friedman, Y. Li, T.L. Pedersen and J.W. Newman. Univ. of
Connecticut, Indiana Univ. Sch. of Med. and USDA, Davis.
D440 I1080.7Effects of antenatal micronutrient
supplementation on plasma protein profiles in Nepalese
children. S.E. Lee, K.P. West, Jr., R.N. Cole, I. Ruczinski, K.
Schulze, J.D. Yager, J. Groopman and P. Christian. Johns
Hopkins Bloomberg Sch. of Publ. Hlth. and Johns Hopkins Sch.
of Med.
LAST DAY TO
VISIT EXHIBITS
Tuesday, April 23
9:00 AM – 4:00 PM
366
1081.NUTRIENT REGULATION OF EPIGENETICS IN
MATERNAL PROGRAMMING
Poster
(Sponsored by: Nutrient-Gene Interactions RIS)
Exhibit Halls A-B
D441 I1081.1Obesogenic phenotype of offspring
of dams fed a high multivitamin diet is prevented by a postweaning high multivitamin or high folate diet. C.E. Cho, D.
Sanchez-Hernandez, S.A. Reza-Lopez, P.S.P. Huot, Y-I. Kim
and G.H. Anderson. Univ. of Toronto and St. Michael’s Hosp.
D442 II1081.2Maternal obesity and post-natal high
fat diet disrupt hepatic circadian rhythm in rat offspring. K.
Shankar, S.J. Borengasser, J. Faske, P. Kang and H. GomezAcevedo. Arkansas Children’s Nutr. Ctr. and Univ of Arkansas
for Med. Sci.
1082.ANIMAL RESEARCH MODELS FOR
MACRONUTRIENT METABOLISM
Poster
(Sponsored by: Experimental Animal Nutrition RIS)
Exhibit Halls A-B
D443 I1082.1Effects of a high fat or a high
carbohydrate diet and exercise on energy substrate utilization
in rat brain. X. Minjun, T. Sonou, T. Fujii, A. Nakashima, C.
Tanaka and K. Okamura. Osaka Univ. of Hlth. and Sport Sci.
D444 II1082.2Protein turnover in pregnant pigs when
feeding limiting amounts of amino acids. S. Moehn, M. Rafii,
P.B. Pencharz and R.O. Ball. Univ. of Alberta and The Hosp.
for Sick Children, Toronto.
D445 I1082.3Expression of transcription factors
involved in lipid metabolism in mice fed algae, yeast, or fish oil.
L.T. Clevenger, K. Barnes, J. Ketz and M. Rodavich. West
Virginia Univ.
D446 II1082.4Impact of high saturated lipids diet
on serum fatty acid profile in rats. P.D. Perris, C. Silva, I.
Fernandez, C. Mambrin, N. Slobodianik and M.S. Feliu. Sch.
of Nutr., Fac. of Pharm. and Biochem., Univ. of Buenos Aires.
1083.ANIMAL RESEARCH MODELS INVESTIGATING
NUTRITION AND INFLAMMATION
Poster
Exhibit Halls A-B
D447 I1083.1Porcine
prepubertal
obesity
is
associated with altered adipokine mRNA in visceral and
subcutaneous fat. W. Zhang, J. Scheffler, J. Escobar, H.
Reeves, G. Van Eyk, K. Fisher, K. Seelenbinder, K. Price, T.
Scheffler, X. Zhao and E. Gilbert. Virginia Tech, Novus Intl.
Inc., Charles, MO and Sichuan Agr. Univ., China.
TUESDAYNUTRITION/PATHOLOGY
D448 II1083.2Development of a piglet model of
neonatal systemic Staphylococcus aureus infection. E.A.
Reznikov, J.L. Hoeflinger, M.H. Monaco, M.J. Miller and S.M.
Donovan. Univ. of Illinois, Urbana.
D449 I1083.3Dietary açai fruit improves cognition
and mobility in aged rats. M.G. Miller, D.R. Fisher, A.N. Carey,
S.M. Poulose and B. Shukitt-Hale. Tufts Univ., USDA at Tufts
Univ. and Simmons Col.
D450 II1083.4The protective effects of alginate and
fucoidan from the brown seaweed on the alcohol-induced liver
damage. T. Kim, Y-J. Kim, J.D. Lim and E-H. Sohn. Kangwon
D451 I1083.5Blueberry supplementation improves
memory in middle aged mice consuming a high fat diet. A.N.
Carey and B. Shukitt-Hale. Simmons Col. and USDA at Tufts
Univ.
D452 II1083.6Improved insulin sensitivity and reduced
adiposity with aP2 driven TLR4 overexpression in transgenic
mice. K.D. Ono-Moore, L. Zhao, S. Huang, J-a. Kim, J.M.
Rutkowsky, R.G. Snodgrass, D.A. Schneider, M.J. Quon
and D.H. Hwang. Univ. of California, Davis, USDA, Davis, Univ.
of Tennessee, Knoxville, Univ. of Alabama at Birmingham and
Univ. of Maryland Baltimore.
D453 I1083.7The effect of omega-3 polyunsaturated
fatty acid and soy protein isolate supplementation on kidney
function in female polycystic kidney diseased rats. K.H. Maditz,
K. Mock, A. Knecht, N. Nanda, C. Oldaker and J. Tou. West
Virginia Univ.
D454 II1083.8Effects of dietary protein and vitamin A
on retinoids and retinol binding protein in periparturient rats. F.
Foroudi, K.C. Ramsey and P. Rezamand. Univ. of Idaho.
D455 I1083.9Protective effects of ellagic acid on
ethanol-induced toxicity in hepatic HepG2 cells. Y-J. Kim, T.
Kim, S. Namkoog and E-H. Sohn. Kangwon Natl. Univ., South
Korea.
D456 II1083.10Dietary supplementation with a low dose
of (-)-epigallocatechin-3-gallate reduces pro-inflammatory
response in peripheral leukocytes of non-obese type 2 diabetic
GK rat. Y. Uchiyama and K. Mochizuki. Univ. of Shizuoka and
Univ. of Yamanashi, Japan.
1084.ANIMAL RESEARCH MODELS IN NUTRITION
AND MUSCULOSKELETAL DEVELOPMENT
Poster
Exhibit Halls A-B
D457 I1084.1Amiloride
derivative
phenamil
restricts long bone growth in broilers in conjunction with zinc
accumulation. T. Price, K.L. Moncada, K.W. Park, P. Tontonoz
and R.L. Walzem. Texas A&M Univ., Sungkyunkwan Univ.,
South Korea and HHMI, UCLA.
D458 II1084.2The effects of silk fibroin on bone
metabolism in ovariectomized rats. S.H. Shin, JY. Yoon, J-W.
Chon, K-G. Lee, H.Y. Kweon, Y-Y. Jo, H-S. Lee and Y-K. Park.
Grad. Sch. of East-West Med. Sci., Kyung Hee Univ. and Natl.
Acad. of Agr. Sci., Suwon, South Korea.
D459 I1084.3High resolution in vivo microcomputed tomography is preferential over dual energy X-ray
absorptiometry for detecting bone loss in the orchidectomized
guinea pig. I.L. Mak, J.R. DeGuire, P. Lavery, S. Agellon and
H.A. Weiler. Sch. of Dietetics and Human Nutr., McGill Univ.
D460 II1084.4Distinct role of Rheb and Grb10 in the
regulation of mTORC1 signaling in skeletal muscle of neonatal
pigs. A. Suryawan, H.V. Nguyen and T.A. Davis. USDA, Baylor
Col. of Med.
Pathology
1085.PATHOPHYSIOLOGY OF CARDIOVASCULAR
DISEASE
Poster
Exhibit Halls A-B
Presentation time: 11:45 am-1:45 pm
A390 1085.1 Exercise training on left ventricular interstitial
collagen in spontaneously hypertensive rats. L.U. Pagan,
R. Damatto, M. Cezar, A. Lima, C. Bonomo, D. Guizoni,
P. Martinez, R. Gimenes, M. Okoshi and K. Okoshi. Univ.
Estadual Paulista-UNESP, Botucatu, Brazil.
A391 1085.2 The possible role of serum from septic
mice in dystrophin proteolysis in cultured newborn mice
cardiomyocytes. L.M.M. Malvestio, C.M. Prado, M.R.N. Celes,
E.C. Campos, P.M. Ferezin and M.A. Rossi. Univ. of São
Paulo, Ribeirão Preto.
A392 1085.3 Chronic hypoestrogenism promotes apoptotic
death in cardiac myocytes of the left ventricular myocardium.
Y.V. Liskova , E.A. Kovalevskaya, S.P. Salikova, A.A.
Stadnikov and E.V. Blinova. Orenburg State Med. Acad.,
Municipal Clin. Emer. Hosp. No.1, Orenburg and Kirov Military
Med. Acad., Russia.
A393 1085.4 Search for plasma biomarkers for dilated
cardiomyopathy using a mouse model with sialyltransferase
transgenes. O. Suzuki. Natl. Inst. of Biomed. Innovation,
Ibaraki-shi.
A394 1085.5 P2Y2 receptor deficiency reduces vascular
inflammation and atherosclerosis in mice. C. Seye. Indiana
Univ. Sch. of Med.
A395 1085.6 Reduced BDNF attenuates inflammation and
angiogenesis to improve survival and cardiac function following
myocardial infarction in mice. G.V. Halade, Y. Ma, T.R. Ramirez,
J. Zhang, Q. Dai, J.G. Hensler, E.F. Lopez, O. Ghasemi, Y-F.
Jin and M.L. Lindsey. Univ. of Texas Hlth. Sci. Ctr. and Univ. of
Texas at San Antonio.
A396 1085.7 Pressure overload amplifies IL-18 signaling
in a rabbit model of myocardial hypertrophy and failure. T.
Yoshida, M. Srinivas, I. Friehs, P.J. del Nido, N. Somanna,
A.J. Valente and B. Chandrasekar. Tulane Univ. Sch. of Med.,
Univ. of Texas Hlth. Sci. Ctr. at San Antonio and Harvard Med.
Sch.
367
T
U
E
PATHOLOGYTUESDAY
A397 1085.8 Influence of late exercise training on myostatin
and follistatin expression in soleus muscle of rats with chronic
heart failure. D.M. Guizoni, S.A. Oliveira Junior, P.F. Martinez,
A.R.R. Lima, C. Bonomo, R.L. Damatto, M.D.M. Cezar, L.U.
Pagan, L.A.M. Zornoff, K. Okoshi and M.P. Okoshi. Botucatu
Med. Sch., Brazil.
A398 1085.9 Adiponectin
inhibits
leptin-induced
cardiomyocyte hypertrophy by attenuation of calcineurin/NFAT
activation. V. Rajapurohitam, B. Suen and M. Karmazyn.
A399 1085.10 Muscle ring finger 1 (MuRF1) and MuRF2
regulate gene expression mediated by the E2F transcription
factors and are necessary but functionally redundant during
developmental cardiac growth in vivo. M.S. Willis, K.M.
Wadosky and C. Patterson. Univ. of North Carolina at Chapel
Hill.
A400 1085.11 Cardiomyocytes hypertrophy in vitro are
induced by TLR2 and TLR4 agonists through NF-kB pathway.
F.G. Silva and M.S.C. Ramos. Fed. Univ. of ABC, Brazil.
A401 1085.12 Expression of cardiolipin biosynthesis and
remodeling enzymes in adult heart failure. J.E. Grudis, K.C.
Chatfield, G.C. Sparagna, J. Hijmans, R.D. Sobus, C.C.
Sucharov, S.D. Miyamotto and B.L. Stauffer. Sch. of Med.,
Univ. of Colorado Denver, Children’s Hosp. Colorado, Aurora,
Univ. of Colorado Boulder and Univ. of Colorado Denver,
Aurora.
A402 1085.13 New susceptibility locus for obesity and
dyslipidemia on chromosome 3q22.3. N. Dzimiri, M. Al-Najai,
P. Muiya, E. Andres, N. Mazher, M. Alshahid and B.F. Meyer.
King Faisal Spec. Hosp. and Res. Ctr., Saudi Arabia.
A403 1085.14 The HNF1a is a susceptibility gene for
myocardial infarction and dyslipidaemia. P. Muiya, M. AlNajai, N. Mazher, E. Andres, M. Alshahid, B.F. Meyer and N.
Dzimiri. King Faisal Spec. Hosp. and Res. Ctr., Saudi Arabia.
A404 1085.15 Evaluation of the HNF1a gene as a risk factor
for metabolic syndrome in the Saudi population. D.M. Bakheet,
M. Al-Najai, N. Mazher, S. Elhawwari, E. Andres, M. Alshahid,
P. Muiya, B.B. Meyer and N. Dzimiri. King Faisal Spec. Hosp.
& Res. Ctr., Saudi Arabia.
A405 1085.16 Examining the role of cytoskeletal signaling
in cardiac preconditioning. A.J. Perricone, B.J. Bivona, F.R.
Jackson and R.S. Vander Heide. LSU Hlth. Sci. Ctr. , New
Orleans.
A406 1085.17 Physical rehabilitation based on the
phenomenon of ischemic preconditioning in patients with
ischemic heart disease. N.P. Lyamina, E.V. Kotelnikova, E.S.
Karpova, V.N. Senchikhin, S.V. Lyamina, H.F. Downey and
E.B. Manukhina. Saratov Res. Inst. of Cardiol., Moscow State
Univ. of Med. and Dent., Univ. of North Texas Hlth. Sci. Ctr. and
Inst. of Gen. Pathol. and Pathophysiol., Moscow.
A407 1085.18 Deficiency of apoptosis inducing factor
decreases complex I activity and increases the ROS generation
in isolated cardiac mitochondria. K. Szczepanek, Y. Hu, E.
Lesnefsky and Q. Chen. Virginia Commonwealth Univ. and
McGuire VA Med. Ctr.
A408 1085.19 Plasma Hsp27 and phosphorylated Hsp27
levels as biomarkers of cardiovascular disease. W.T.
Gerthoffer, L.T. Muphy, C. Malozzi and C.V. Massey. Univ. of
South Alabama.
A409 1085.20 Reactive oxygen species and electron flow are
needed to oxidize cytochrome c at the methionine residues.
H.S. Aluri, Q. Chen, Y. Hu and E.J. Lesnefsky. Virginia
Commonwealth Univ. and McGuire VA Med. Ctr.
368
1086.CELL STRESS AND CELL DEATH
Poster
Exhibit Halls A-B
A410 1086.1 Mechanism underlying the antioxidant activity
of taurine. C.J. Jong and S. Schaffer. Univ. of South Alabama.
A411 1086.2 Modulation of autophagy affects the hepatic
pathology in alcoholic and non-alcoholic liver diseases. H.
Zhang, B. Khambu, X. Chen and X-M. Yin. Indiana Univ. Sch.
of Med.
A412 1086.3 Autophagy in neuronal bioenergetics and
survival. J. Zhang, M. Dodson, Q. Liang, G. Benavides and
V.M. Darley-Usmar. Univ. of Alabama at Birmingham and
Birmingham VA Med. Ctr.
A413 1086.4 Induction of apoptosis in the bone marrow
promotes regenerative actions of parathyroid hormone in
bone. A.J. Koh, S.W. Cho, P. Entezami, G. Pettway and L.
McCauley. Univ. of Michigan.
A414 1086.5 Role of bile acids in autophagy and alcoholinduced liver injury. S. Manley, H. Ni, H. Yang, G. Guo, U. Apte
and W-X. Ding. Univ. of Kansas Med. Ctr.
A415 1086.6 Autophagy in pituitary tumors. F. Rotondo, E.
Horvath, K. Kovacs, L.V. Syro and S. Yamada. St. Michael’s
Hosp., Toronto, Pablo Tobon Uribe Hosp., Medellin, Colombia
and Toranomon Hosp., Tokyo.
A416 1086.7 Prolonged NLRP3 inflammasome activation
enhances the secretion of autophagy-derived vesicles
containing LC3II in murine dendritic cells. H.M. Russo and
G.R. Dubyak. Case Western Reserve Univ.
A417 1086.8 Caspase-generated neoepitopes as markers
of axonal degeneration in neural development and injury. J.D.
Sokolowski, D.S. Heffron, C. Deppmann, A.C. LeBlanc and
J.W. Mandell. Univ. of Virginia and McGill Univ.
A418 1086.9 Evaluation of antioxidant defense in patients
undergoing minor elective surgery with balanced anesthesia
maintained with the inhaled isoflurane. M.G. Braz, D. Salvadori,
L. Braz, J.R. Braz, G. Tang and K-J. Yeum. São Paulo State
Univ. and USDA at Tufts Univ.
A419 1086.10 PGC-1 isoforms modulate the antioxidant
response of photoreceptors to photo-oxidative stress. J.
Iacovelli, Z. Arany and M. Saint-Geniez. Schepens Eye Res.
Inst., Mass Eye and Ear Infirm., Harvard Med. Sch. and Beth
Israel Deaconess Med. Ctr.
A420 1086.11 Low respiratory quotients in chow-fed male
bonnet macaque monkeys as an indicator of metabolic stress
due to single cage housing. R. Rising and J. Lin. D & S
Consulting Svcs. Inc., New York and Plexxikon Inc., Berkeley.
A421 1086.12 High MUC2 production in goblet cells caused
ER stress and susceptibility to apoptosis. A.A. Tawiah, F.
Moreau and K. Chadee. Univ. of Calgary, Canada.
A422 1086.13 Cisplatin nephrotoxicity involves mitochondrial
injury with impaired tubular mitochondrial enzyme activity. Z.K.
Zsengeller, P. Mukhopadhyay, B. Kalyanaraman, S. Parikh,
A.S. Karumanchi, I.E. Stillman and P. Pacher. Beth Israel
Deaconess Med. Ctr., NIAAA, NIH and Med. Col. of Wisconsin.
A423 1086.14 Cigarette smoking affects human semen
quality in synergy with functional Nrf2 polymorphisms. Z.
Huang and B. Yu. Sun Yat-sen Univ. and Third Affiliated Hosp.
of Guangzhou Med. Univ., China.
TUESDAYPATHOLOGY
A424 1086.15 Cigarette
smoke-induced
myocardial
inflammation and contractile dysfunction is mediated by
unsaturated aldehydes and TRPV1. E.Y. He, Z. Wu, G.I. Scott
and J. Ren. Univ. of Wyoming, Fourth Military Med. Univ.,
China.
A425 1086.16 Bromelain prevents mouse testis from tert-butyl
hydroperoxide-induced dysfunction by inhibiting apoptosis,
inflammation, and cellular senscence. Y-C. Yeh, C-H. Tsai,
T-J. Liu, H-C. Lai and L-C. Wang. Nanhua Univ. and Taichung
Veterans Gen. Hosp., Taiwan.
1087.INTRA- AND EXTRACELLULAR BIOLOGY OF
MALIGNANCY
Poster
Exhibit Halls A-B
A426 1087.1 Proteomic profiling of thyroid follicular
adenoma. X. Lai. Indiana Univ. Sch. of Med.
A427 1087.2 Floating cultured melanoma cells are a distinct
subpopulation enriched for cancer stem cell biomarkers. J.
Huang, C-W. Lee, Y-T. Chuang and G.F. Murphy. Brigham
and Women’s Hosp., Harvard Med. Sch. and Boston Children’s
Hosp.
A428 1087.3 Interaction of MCM7 and RACK1 for activation
of MCM7 and cell growth. X. Zhang, Y.P. Yu and J-H. Luo. Univ.
of Pittsburgh.
A429 1087.4 Patterned laminin expression by spheroidforming melanoma cells. A.R. Larson, C. Lezcano, C-W. Lee,
J. Huang, Q. Zhan and G.F. Murphy. Brigham and Women’s
Hosp., Harvard Med. Sch.
A430 1087.5 Scanning
acoustic
microscopy
for
characterization of gastric lesions. K. Miura and S. Yamamoto.
Hamamatsu Univ. Sch. of Med., Japan.
A431 1087.6 High prevalence of Chlamydophila psittaci
subclinical infection in Italian patients with Sjögren’s syndrome
and parotid gland B-cell lymphoma. M. Fabris, R. Dolcetti, E.
Pasini, L. Quartuccio, E. Pontarini, M. Ponzoni, C.A. Scott,
F. Curcio and S. De Vita. Univ. Hosp. of Udine, NCI of Aviano,
Humanitas Clin. Inst., Rozzano (Milan) and San Raffaele Sci.
Inst., Milan.
A432 1087.7 Identification of PKM2 interacting proteins by
tandem mass spectrometry. S.R. Hwang, S.R.P. McDonnell, V.
Basrur, K.P. Conlon, D. Fermin, C. Murga-Zamalloa, K.S.J.
Elenitoba-Johnson and M.S. Lim. Univ. of Michigan.
A433 1087.8 Expression of MDR-transporter, ABCB5, in
Merkel cell carcinoma. C. Lezcano, S. Kleffel, A.C. Laga,
Q. Zhan, A. DoRosario, M.H. Frank, L. Wang, G.F. Murphy
and T. Schatton. Brigham and Women’s Hosp., Dana-Farber
Cancer Inst., Children’s Hosp. Boston and Mercy Med. Ctr.,
Baltimore.
A434 1087.9 cGMP-dependent protein kinases (PKG-Ib and
PKG-II) modulate b-catenin/TCF pathway in cancer cells. H.
Sellak, S. Wu and T.M. Lincoln. Georgia Hlth. Sci. Univ. and
Univ. of South Alabama.
A435 1087.10 Differential antibody responses to HPV16 in
cervical and oropharyngeal cancer. E.R. Unger, G. Panicker,
J. Wong, G. Wallstrom, R. Haddad, G. D’Souza, M. Posner
and K.S. Anderson. Ctrs. for Dis. Control and Prevent., DanaFarber Cancer Inst., Arizona State Univ., Johns Hopkins Sch.
of Publ. Hlth. and Mount Sinai Sch. of Med.
A436 1087.11 IFN-gamma specifically targets melanoma
stem cells and inhibits in vitro spherogenic growth. C-W. Lee, J.
Huang, Y-T. Chuang and G.F. Murphy. Brigham and Women’s
Hosp. , Harvard Med. Sch. and Boston Children’s Hosp.
A437 1087.12 Association of HER2 Ile655Val and Ala1170Pro
polymorphisms with breast cancer prognosis factors. D. Furrer,
C. Laflamme, M-A. Côté, L. Provencher, F. Barabé, S. Jacob,
C. St-Pierre, É. Demers, R. Tremblay-LeMay, C. NadeauLarochelle, A. Michaud, J. Lemieux and C. Diorio. Res. Ctr.
CHUQ, Laval Univ. Canada.
A438 1087.13 An interleukin-15 fusion protein enhances the
oncolytic effects of myxoma virus in a murine melanoma model.
A.L. MacNeill, V. Tosic, R.A. Doty, J. Liu, G. McFadden and
E.J. Roy. Univ. of Illinois, Urbana and Univ. of Florida.
A439 1087.14 Anti-angiogenic activity of alpha7-nicotinic
receptor antagonists in human small cell lung cancer. B.A.
Thornhill, K.C. Brown, J.K. Lau, A.M. Dom, T.R. Witte, W.E.
Hardman, H. Luo, Y.C. Chen and P. Dasgupta. Joan C.
Edwards Sch. of Med., Marshall Univ. and Alderson-Broaddus
Col., WV.
A440 1087.15 Role of C-terminal domain of E-cadherin in
activating b-catenin/TCF pathway in cancer cells under hypoxic
conditions. H. Sellak, S. Wu and T.M. Lincoln. Georgia Hlth.
Sci. Univ. and Univ. of South Alabama.
A441 1087.16 Cav1 is a key mediator of tumor-stromal
interactions in melanoma. C. Trimmer and F. Capozza.
Thomas Jefferson Univ.
A442 1087.17 WNT5a-mediated tumor suppression of
esophageal adenocarcinoma in vitro. T. Moore, O. Lyros, L.
Nie, N. Jovanovic, R. Medda, T. Perkins, M. Otterson and R.
Shaker. Med. Col. of Wisconsin.
A443 1087.18 Are the intrarenal hormones the culprit in renal
cell carcinoma? C.A. Jackson and D.D. Canionero. Tuskegee
Univ.
A444 1087.19 Epigenetic regulation of PTEN in hepatic
cancer. X.V. Qadir, C. Han and T. Wu. Tulane Univ. Sch. of Med.
1088.ADVANCES IN DIAGNOSIS AND TREATMENT
OF MALIGNANCY
Poster
Exhibit Halls A-B
A445 1088.1 Role of HO-1 in neuroblastoma resistance
to bortezomib. A. Furfaro, S. Piras, M. Passalacqua, C.
Domenicotti, M.A. Pronzato, U.M. Marinari, L. Moretta, N.
Traverso and M. Nitti. Univ. of Genoa and Giannina Gaslini
Inst., Genoa.
A446 1088.2 mTOR inhibition leads to decrease of breast
cancer progression in vitro via cytoskeleton remodeling. O.
Cherednyk, A. Khoruzhenko, V. Kosach and V. Filonenko.
Inst. of Molec. Biol. and Genet., NAS of Ukraine, Kiev.
A447 1088.3 The pMAPK/pAMPK ratio modulates the
effect of adiponectin on breast cancer cell growth. L. Mauro,
M. Pellegrino, E. Ricchio, F. De Amicis, S. Catalano, D.
Bonofiglio, P. Rizza, M.L. Panno and S. Andò. Univ. of
Calabria, Italy.
A448 1088.4 Combinatorial
treatment
of
malignant
peripheral nerve sheath tumors with tyrosine kinase inhibitors
hinders proliferation and survival. S.N. Brosius, K.A. Roth and
S.L. Carroll. Univ. of Alabama at Birmingham.
369
T
U
E
PATHOLOGY/PHARMACOLOGYTUESDAY
A449 1088.5 Aptamer-drug conjugates for targeted therapy
of CD30-expressing lymphomas. P.A. Parekh, S.R. Kamble, Z.
Zihua and Y. Zu. The Methodist Hosp. Res. Inst., Houston.
A450 1088.6 A targeted iron-based MRI contrast for tumor
detection. D.R. Mills, E.G. Walsh, K.E. Brilliant, D.C. Hixson
and W.K.C. Park. Rhode Island Hosp. and Brown Univ.
A451 1088.7 An ultra pH-sensitive and aptamer-equipped
hollow gold nanosphere for selective killing of tumor cells. N.
Zhao, J. You, Z. Zeng, C. Li and Y. Zu. The Methodist Hosp.
Res. Inst. and Univ. of Texas MD Anderson Cancer Ctr.
A452 1088.8 Comparison of micro-bubble assisted p53,
pRB, and p130 gene therapy in combination with radiation
therapy in prostate cancer in vitro and in vivo. R.P. Nande,
M.S. Gossman, J.P. Lopez, C.M. Howard, J. Denvir and
P.P. Claudio. Marshall Univ. and Tri-State Reg. Cancer Ctr.,
Ashland, KY.
A453 1088.9 Development of ssDNA-based aptamers
specific to PSMA. B. Yuan, N. Zhao, S-n. Pei and Y. Zu. The
Methodist Hosp. Res. Inst., Houston.
A454 1088.10 In vivo murine lymph node imaging
with multispectral photoacoustic technology and clinical
contrast agents. A. Heinmiller, C. Hupple, A. Needles, C.
Theodoropoulos and R.W. Wood. VisualSonics Inc., Toronto
and Univ. of Rochester Med. Ctr.
A455 1088.11 MG624, a synthetic small molecule alpha7
receptor antagonist, inhibits growth of human small cell lung
cancer. C.A. McNees, K.C. Brown, J.K. Lau, A.M. Dom, B.
Shiflett, T.R. Witte, W.E. Hardman, H. Luo, Y.C. Chen, A.B.
Carpenter and P. Dasgupta. Joan C. Edwards Sch. of Med.,
Marshall Univ. and Alderson-Broaddus Col., WV.
A456 1088.12Withdrawn.
A457 1088.13 Development of experimental protocol for
photodynamic therapy on colorectal tumors: determination
of irradiation by fluorescence spectroscopy. J. Duarte, A.O.
Ferreira, L. Silveira, Jr. and H. Plapler. Univ. Paulista, São
Jose dos Campos, Fed. Univ. of São Paulo and Univ. Camilo
Castelo Branco, Brazil.
A458 1088.14 p38MAPK inhibition: a new combined approach
to reduce neuroblastoma resistance under etoposide treatment.
B. Marento, R. Ricciarelli, C. De Ciucis, A. Furfaro, R. Colla,
E. Canepa, N. Traverso, U.M. Marinari, M.A. Pronzato and C.
Domenicotti. Univ. of Genoa.
A459 1088.15 Inhibition of lysine-specific histone demethylase
LSD1 suppresses melanoma growth. C.G. Lian, R. Fang, Q.
Zhan, J. Ma, C-W. Lee, M.H. Frank, Y.G. Shi and G.F. Murphy.
Brigham and Women’s Hosp., Harvard Med. Sch. and Boston
Children’s Hosp.
A460 1088.16 Targeting retinoblastoma: therapeutic inhibition
using catalytic antioxidant cerium oxide nanoparticles. K.E.
Klump, X. Cai, R. Towner, S. Seal, M. Dyer and J. McGinnis.
Univ. of Oklahoma Hlth. Sci. Ctr., Oklahoma Med. Res. Fndn.,
Univ. of Central Florida and St. Jude Children’s Res. Hosp.
A461 1088.17 Mouse models of cancer—how to optimize
their predictive value in cancer drug development. G.S. HerterSprie and K-K. Wong. Dana-Farber Cancer Inst. and Harvard
Med. Sch.
A462 1088.18 Develop a novel aptamer-mediated assay for
simultaneous detection of different types of circulating tumor
cells in whole blood samples. Z. Zeng, P. Parekh, N. Zhao and
Y. Zu. The Methodist Hosp., Houston.
A463 1088.19 Molecular histology with high resolution
imaging mass spectrometry. K. Kellersberger, J-M. Kowalski,
M. Becker, S-O. Deininger and S. Cornett. Bruker Daltonics,
Billerica, MA and Bremen, Germany.
Pharmacology and Experimental Therapeutics
1089.CARDIAC SIGNALING
1090.VASCULAR PHARMACOLOGY
Poster
Poster
Exhibit Halls A-B
Exhibit Halls A-B
A1
1089.1 The inhibitory effect of cibenzolineon Na /Ca
exchange current in cardiac myocytes. Y. Watanabe and J.
Kimura. Hamamatsu Univ. and Fukushima Med. Univ., Japan.
A2
1089.2 H2S-induced cardiac protection is caused by
activation of mTORC2/Akt/Bim pathway in an isolated rat heart
ischemia/reperfusion model. Y. Zhou, D. Wang, X. Gao, K.
Lew, A. Richards and P. Wang. Natl. Univ. of Singapore, Putuo
Hosp. and Huashan Hosp., Shanghai.
A3
1089.3 Helium inhalation induces caveolin secretion
to blood. N.C. Weber, J.M. Schilling, J.C. Finley, M. Irvine,
S.E. Kellerhals, I.R. Niesman, D.M. Roth, B. Preckel, M.W.
Hollmann and H.H. Patel. Univ. of Amsterdam, UCSD and VA
San Diego Healthcare Syst.
A4
1089.4 Rapamycin-regulated
ubiquitin
specific
peptidases expression in cardiocytes. A.V.D. Zanetti, L.C.
Santos, V.A. Schoeps, P.S. Sanzovo, J.V.S. Carniello, A.A.S.
Manso, F.W. Sellke and C. Bianchi. Rhode Island Hosp.
+
370
2+
A5
1090.1 Alteration of endothelial CaMKII in AngIIinduced hypertensive mice. C. Charbel, F. Toussaint, A.
Blanchette and J. Ledoux. Montreal Heart Inst. and Univ. of
Montreal.
A6
1090.2 Adenosine A2A receptor modulates vascular
response in soluble epoxide hydrolase-null mice through
cyp2j-epoxygenases and PPARg. M.A. Nayeem, I. Pradhan,
S.J. Mustafa, C. Morisseau, J.R. Falck and D.C. Zeldin.
West Virginia Univ., Univ. of California, Davis, Univ. of Texas
Southwest Med. Ctr. and NIEHS, NIH, Research Triangle Park.
A7
1090.3 PAR-2 receptors modulate nerve-evoked
contraction of resistance arteries. P. Kerr, M. Zwozdesky, M.
Chen, R. Wei and F. Plane. Macewan Univ., Canada and Univ.
of Alberta.
TUESDAYPHARMACOLOGY
A8
1090.4 Lipopolysaccharide
increases
agonistinduced contractile responses in Sprague Dawley rat corpus
cavernosum. I.S. Stallmann-Jorgensen and R.C. Webb.
A9
1090.5 Thrombospondin-1 impairs vasorelaxation
via signal regulatory protein-a-mediated activation of NADPH
oxidase 1. M. Yao, G. Csanyi, A. Rodriguez, D. Roberts, P.
Pagano and J. Isenberg. Midwestern Univ., AZ, Univ. of
Pittsburgh and NCI, NIH.
A10
1090.6 Pharmacological interventions to overcome
reactive oxygen species in hemorrhagic shock. M-F. Doursout,
Y. Liang and L. Vandelaar. Univ. of Texas Med. Sch. at Houston.
A11
1090.7 Toll-like receptor 2 activation increases
adrenergic sensitivity in mesenteric resistance vessels of rats.
T.A. Hardigan, K.P. Nunes, T. Szasz and R.C. Webb. Georgia
Hlth. Sci. Univ.
1091.VASCULAR SIGNALING IN DIABETES
Poster
Exhibit Halls A-B
A12
1091.1 Angiotensin-(1-7) stimulates mobilization of
bone marrow stem/progenitor cells in diabetes. Y. Jarajapu, G.
Vasam, R. Pawar and S. Bartelmez. North Dakota State Univ.
and BetaStem Therapeut. Inc., San Francisco.
A13
1091.2 Toll-like receptor 4 mediates endothelial
dysfunction during type I diabetes. M.A. Carrillo-Sepulveda,
K.P. Nunes and R.C. Webb. Georgia Hlth. Sci. Univ.
A14
1091.3 Cystathionine gamma-lyase deficiency impairs
H2S biosynthesis and vessel reactivity in type-2 diabetes. G.V.
Velmurugan and C. White. Rosalind Franklin Univ.
A15
1091.4 Comparative analysis of the vascular
sympatho-inhibition to moxonidine in control or streptozotocininduced diabetic rats. D. Centurion, E. Moreno-Vázquez, M.T.
Villamil-Hernández, O. Alcántara-Vázquez, S.J. AcostaCota and A. Sánchez-López. Cinvestav-IPN, Mexico City.
A16
1091.5 Effect of pentoxifylline and losartan on insulinresistant equine digital vessels. C.S. Venugopal, E. Holmes,
C. Koch, M. Kearney and S. Eades. LSU Sch. of Vet. Med.
A17
1091.6 Reduced
nitric
oxide–cGMP
signaling
contributes to vascular dysfunction induced by the adipokine
chemerin. K. Neves, N. Lobato, R. Lopes, C. Zanotto, F.
Filgueira, A.M. Oliveira and R. Tostes. Univ. of São Paulo,
Ribeirão Preto.
A18
1091.7 The effect of nitric oxide on blockade of the
norepinephrine transporter, uptake-1, by atomoxetine. J.A.
Simaan. American Univ. of Beirut.
A19
1091.8 The
oligomerized
polyphenol
oligonol
ameliorates high glucose- and TNF-a-induced NADPH oxidase
activation and insulin signaling downregulation in vascular
endothelial cells. H. Yokoo, K. Taguchi and Y. Hattori. Univ. of
Toyama, Japan.
1092.VASCULAR SMOOTH MUSCLE SIGNALING
Poster
Exhibit Halls A-B
A20
1092.1 Abnormal calcium homeostasis in the aorta of
the spontaneously hypertensive rat is mediated by endoplasmic
reticulum stress. K. Spitler and R.C. Webb. Georgia Hlth. Sci.
Univ.
A21
1092.2 Differential contribution of pannexin-1 channels
to agonist and neurogenic constriction of mesenteric arteries
and veins from normotensive and DOCA-salt hypertensive rats.
J. Hernandez, H. Xu, S. Sangsiri and J. Galligan. Michigan
State Univ.
A22
1092.3 a1-Adrenergic receptor activation rapidly
upregulates L-type Ca2+ channels in rat mesenteric arteries in
vivo. A.K. Srivastava, S.V. Kharade, T.W. Fletcher, S.W. Rhee
and N.J. Rusch. Univ. of Arkansas for Med. Sci.
A23
1092.4 Modulation of vascular response by high salt
intake depends on the presence or absence of adenosine A2A
receptor using A2A AR-null mice. I. Pradhan, S.J. Mustafa,
D.C. Zeldin, C. Ledent, J.R. Falck and M.A. Nayeem. West
Virginia Univ., NIEHS, NIH, Research Triangle Park, Univ. Libre
of Brussels and Univ. of Texas Southwestern Med. Ctr., Dallas.
A24
1092.5 Mechanism of glabridin-mediated vasorelaxation of rat main mesenteric artery. P. Aaronson and D. Chanda.
King’s Col. London.
A25
1092.6 Dynein-mediated lysosome trafficking in
autophagic flux of mouse coronary arterial myocytes. M. Xu, X.
Li, Y. Zhang and P-L. Li. Virginia Commonwealth Univ.
A26
1092.7 Endothelial dysfunction accentuates the loss of
function of beta adrenergic receptors in the smooth muscle of
the rat aorta during maturation. O. Lopez-Canales, J. LopezCanales, G. Guevara-Balcazar, M.C. Castillo-Hernandez
and B. Escalante-Acosta. Med. Sch. and CINVESTAV del
IPN, Mexico City.
A27
1092.8 Testosterone induces activation of the extrinsic
apoptotic pathway in VSMC by mechanisms involving ROS
generation. R. Lopes, K. Neves, A. Chignalia, C. Zanotto, C.
Pestana, C. Curti and R. Tostes. Univ. of São Paulo, Ribeirão
Preto.
1093.GASTROINTESTINAL PHARMACOLOGY
Poster
Exhibit Halls A-B
A28
1093.1 The role of FcRn in monoclonal antibody serum
uptake from the intestine in suckling rat pups. P.R. Cooper, C.
Kliwinski, R. Perkinson, J. Mabus, J. Giles-Komar and P.
Hornby. Janssen R&D. Radnor, PA.
A29
1093.2 Gastroprotective, ulcer healing and antioxidant
activity of protoberberine alkaloid isolated from partially purified
fraction of crude dichloromethane stem extract of coscinium
fenestratum. P.N. Okechukwu, J. Marunga, N.C. Chiam, P.R.
Godspower and G.A. Akowuah. Ucsi Univ., Malaysia.
371
T
U
E
PHARMACOLOGYTUESDAY
A30
1093.3 FcRn expression and antibody transcytosis in
adult human and non-human primate intestine. P.J. Hornby,
P.R. Cooper, C. Kliwinski, E. Ragwan, J.R. Mabus, B.
Harman, H. Dorai and J. Giles-Komar. Janssen R&D, Radnor,
PA.
A31
1093.4 Bifidobacteria confer protection against
NSAID-enteropathy independently of acetate production.
S.D. Syer, R. Martin, G.W. McKnight, P. Langella and J.L.
Wallace. McMaster Univ., Canada and MICALIS Inst. INRA,
Jouy en Josas.
A32
1093.5 Dihydrotanshinone induced apoptosis in colon
cancer cells by p53-independent but ROS dependent pathway
mediated by mitochondria. L. Wang, J.H.K. Yeung, W.Y.W. Lee,
X.L. Zhou, T. Hu and C.H. Cho. The Chinese Univ. of Hong
Kong.
A33
1093.6 The human host defense peptide cathelicidin
induces AIFf- and EndoG-mediated cell death in colon cancer
cells. C.H. Cho and S.X. Ren. Sch. of Biol. Sci., The Chinese
Univ. of Hong Kong.
A34
1093.7 Cathelicidin is a host defense peptide in
controlling Helicobacter pylori survival and infection. L. Zhang,
J. Yu, W.K.K. Wu and C.H. Cho. The Chinese Univ. of Hong
Kong and Prince of Wales Hosp., Hong Kong.
A35
1093.8 Gender difference in duodenal HCO3- response
to mucosal acidification: importance of upregulation of ASIC3
by estradiol. K. Takeuchi, Y. Ohashi, K. Amagase and E.
Aihara. Kyoto Pharmaceut. Univ.
A36
1093.9 Role of calcium-sensing receptor on gastric
acid secretion in isolated mouse stomachs. K. Takeuchi, S.
Hayashi, K. Amagase and E. Aihara. Kyoto Pharmaceut.
Univ.
A37
1093.10 Mucosal
protective
agents
prevent
exacerbation of NSAID-induced small intestinal lesions caused
by antisecretory drugs in rats. H. Satoh, K. Amagase, A. Yokoi,
M. Ohashi, S. Kuwata, S. Mochizuki and K. Takeuchi. Kyoto
Pharmaceut. Univ.
A38
1093.11 Cortricotropin-releasing factor (CRF) may
protect the gastric mucosa against injury through involvement
CRF1 and CRF2 receptor types. L. Filaretova, O. Morozova,
M. Myazina and T. Bagaeva. Pavlov Inst. of Physiol., St.
Petersburg, Russia.
A39
1093.12 Evidence of NSAID partitioning into splanchnic
lymphatics: possible route to avoid first-pass hepatic
metabolism. L.M. Lichtenberger, T. Phan and E. Dial. Univ of
Texas Hlth. Sci. Ctr. at Houston.
A40
1093.13 The effect of a hydrogen sulfide-releasing nonsteroidal anti-inflammatory drug on gastric and renal damage
in streptozotocin-induced diabetic rats. M. Chan, R. Blackler,
W. McKnight and J. Wallace. McMaster Univ., Canada.
A41
1093.14 Bacterial stimulation of endogenous hydrogen
sulfide synthesis: a novel mechanism for resolution and repair
in the colon. K. Flannigan, E. Verdu and J. Wallace. McMaster
Univ., Canada.
A42
1093.15 Reversal of p-glycoprotein mediated multidrug
resistance by cryptotanshinone and dihydrotanshinone. T. Hu,
J.H.K. Yeung, L. Wang, X. Zhou, P.M.Y. Or, K.K.W. To and C.H.
Cho. Sch. of Biomed. Sci. and Sch. of Pharm., The Chinese
Univ. of Hong Kong.
A43
1093.16 The newer therapeutic alternatives to the
acid-oriented approach via targeting endothelial metabolism
in esophagoprotection by 5-hydroxytryptamine and melatonin.
O. Zayachkivska, M. Savytska, S. Mandrusyak and A.
Yaschenko. Lviv Natl. Med. Univ., Ukraine.
372
A44
1093.17 Losartan protection against CCL4-induced
hepatic fibrosis involves changes in adhesion molecules and
inflammatory markers. N.N. Nassar, S.A. El Wakeel, M.I. El
Sayed and E.S.M. El-Denshary. Fac. of Pharm., Cairo Univ.,
Misr Intl. Univ. and Sinai Univ., Egypt.
A45
1093.18 Stable gastric pentadecapeptide BPC 157 for
colitis and multiple sclerosis: healing of cysteamine-colitis and
colon-colon-anastomosis. P. Sikiric, R. Klicek, D. Kolenc, J.
Suran, D. Drmic, L. Brcic, G. Aralica, S. Seiwerth and R.
Rucman. Med. Fac., Univ. of Zagreb, Croatia.
A46
1093.19 TCP-1 as a novel phage-display peptide
targeting colon cancer. L. Lan and C.C. Hin. The Chinese Univ.
of Hong Kong.
A47
1093.20 Additive antiemetic efficacy of D9-THC with
vanilloid TRPV1 receptor agonists in the least shrew (Cryptotis
parva). R.S. Brar, S. Chebolu, W. Zhong and N.A. Darmani.
COMP, Western Univ., CA.
A48
1093.21 Both supraspinal and spinal mechanisms may
be involved in the maintenance of gastric mucosal integrity in
the rat. K. Gyires, V. Tóth, K. Király, I. Barna and Z.S. Zádori.
Semmelweis Univ. and Inst. of Exptl. Med., Budapest.
A49
1093.22 Antiviral activity of Bifidobacterium longum
SPM1205, 1206 and Lactobacillus ruminis SPM0211 against
rotavirus. J-Y. Kang, D-K. Lee, M-J. Kim, J-E. Park, H-S. Shin
and N-J. Ha. Col. of Pharm., Duksung Women’s Univ. and Col.
of Pharm., Sahmyook Univ., South Korea.
A50
1093.23 Antiviral activity of Bifidobacterium adolescentis
SPM1605 against coxsackievirus B3. M.J. Kim, D.K. Lee, J.Y.
Kang, J.E. Park and N.J. Ha. Sahmyook Univ. and DukSung
Women’s Univ., South Korea.
A51
1093.24 Electrophysiological
characterization
of
purinergic receptors in mouse enteric neuron-glia culture. A.R.
Gade and H.I. Akbarali. Virginia Commonwealth Univ.
A52
1093.25 Signaling pathways in control of gastric acid
secretion and food-stomach-bone axis revealed by gene
expression profiling in the stomach of genetically targeted
mice deficient in CCK1 receptor and gastrin/CCK2 receptor.
D. Chen and C-M. Zhao. Norwegian Univ. of Sci. and Technol.,
Trondheim.
A53
1093.26 Pentadecapeptide BPC 157 after 70% liver
resection in rats. P. Sikiric, D. Crvenkovic, M. Sever, N. Lojo,
Z. Krstonijevic, D. Drmic, A. Zenko, L. Brcic, I. Zoricic,
Z. Rasic, R. Rucman and S. Seiwerth. Med. Fac., Univ. of
Zagreb, Croatia.
A54
1093.27 R-type Ca2+ channels and inhibitory
neuromuscular transmission in the gastrointestinal tract. E.
Rodriguez-Tapia and J. Galligan. Michigan State Univ.
A55
1093.28 Macrophage infiltration and oxidative stress in
rat ileum cause loss of nitrergic inhibitory neurons in DOCAsalt hypertensive rats. L. Thang, D. Fried and J. Galligan.
Michigan State Univ.
A56
1093.29 Electrophysiological properties of colonprojecting sensory neurons in male and female serotonin
transporter knockout rats. S. Schneider, H. Wang, D. Fried
and J. Galligan. Michigan State Univ. and Univ. of Michigan.
A57
1093.30 Peripheral and central NK1 receptors in emesis
control in Suncus murinus. J.A. Rudd, F.H.M. Cheng and B.
Moreaux. Sch. of Biomed. Sci., Chinese Univ. of Hong Kong,
Hong Kong and Johnson and Johnson R&D, Belgium.
A58
1093.31 Transcription factor Egr-1 in molecular
mechanisms of experimental gastric ulcers. S. Beregoviy, V.
Kukharskyy, K. Bernyk, T. Beregova and G. Tolstanova.
Taras Shevchenko Natl. Univ. of Kiev, Ukraine.
TUESDAYPHARMACOLOGY
A59
1093.32 Redox regulation of the KATP channel complex
in colonic inflammation. M. Kang, A.R. Gade and H.I. Akbarali.
Virginia Commonwealth Univ.
1094.G PROTEINS
Poster
Exhibit Halls A-B
A60
1094.1 Constitutive activity of Gs a R201H is
suppressed by disruption of either of two hydrophobic pockets
within the protein. R. Pals-Rylaarsdam, K. Turcic, J. Carroll,
R. Tobar-Rubin, D. Janevska, E. Din, R. Alvarez and F.
Choudhry. Benedictine Univ., IL.
A61
1094.2 The mechanism of the Ric-8 protein
requirement in heterotrimeric G protein biosynthesis. P.Y. Chan
and G. Tall. Univ. of Rochester.
A62
1094.3 Identification of a novel activator of GOA1, a trimeric G protein critical for early stages of C. elegans
development. B.D. Coleman, L.T. Nguyen and M. GarciaMarcos. Boston Univ. Sch. of Med. and Boston Univ.
A63
1094.4 Activation of the G(s) heterotrimer monitored
in living cells with novel G(s) biosensors. H. Yano, D. Provasi,
M. Filizola, S. Ferre and J.A. Javitch. Columbia Univ., NIDA,
NIH, Baltimore and Mount Sinai Sch. of Med.
1095.RGS/AGS PROTEINS
Poster
Exhibit Halls A-B
A64
1095.1 Transcriptional suppression, DNA methylation,
and histone deacetylation of the regulator of G-protein signaling
10 (RGS10) gene in ovarian cancer cells. M.W. Ali, E. Cacan, Y.
Liu, S.T. Eblen, S.F. Greer and S.B. Hooks. Univ. of Georgia,
Georgia State Univ. and Med. Univ. of South Carolina.
A65
1095.2 GPR158 and GPR179: a subfamily of orphan
GPCRs as a new class of G protein signaling modulators. C.
Orlandi, I. Masuho, E. Posokhova, Y. Cao, T. Ray, N. Hasan,
R. Gregg and K. Martemyanov. The Scripps Res. Inst., Jupiter,
FL and Univ. of Louisville.
A66
1095.3 RGS 2 and RGS 4 differentially modulate G
protein coupled receptor signaling in the mouse aorta. N.W.
Mabe, S. Seeley, L. Fehrman, P. Garber, R.R. Neubig and
B.R. Rorabaugh. Ohio Northern Univ. Col. of Pharm. and Univ.
of Michigan Med. Sch.
A67
1095.4 Activator of G protein signaling-3 regulates
CXCR4 and CCR7 signaling in murine lymphocytes and bone
marrow-derived dendritic cells. M. Branham-O’Connor, W.G.
Robichaux III, E.M. Maher, X. Zhang and J.B. Blumer. Med.
Univ. of South Carolina.
A68
1095.5 RGS2 protein degradation is mediated by a
novel multiprotein E3 ligase containing Cullin 4b and F box 44.
B. Sjogren, S. Swaney and R. Neubig. Univ. of Michigan.
A69
1095.6 RGS2
regulates
urotensin
II-induced
intracellular Ca2+ elevation and contraction in glomerular
mesangial cells. A. Adebiyi. Univ. of Tennessee, Memphis.
A70
1095.7 Regulation of the AGS4–Gai interaction by
chemokine receptors and the non-receptor guanine nucleotide
exchange factor Ric-8A. W.G. Robichaux III, S.S. Oner, S.M.
Lanier and J.B. Blumer. Med. Univ. of South Carolina.
A71
1095.8 RGS2 repression increases susceptibility of
mice to interleukin-13-induced airway hyperresponsiveness. Y.
Xie, H. Jiang, P.W. Abel, T.B. Casale, R.A. Panettieri and Y.
Tu. Creighton Univ. and Univ. of Pennsylvania.
A72
1095.9 Structural studies of RGS inhibitors. C.A.
Higgins, E. Fuentes and D. Roman. Univ. of Iowa and Univ. of
Iowa Hosps. and Clins.
A73
1095.10 Neuroadaptations in D2-like autoreceptor
function following AMPH self-administration. E.S. Calipari, H.
Sun, S.R. Jones and R. Chen. Wake Forest Sch. of Med.
A74
1095.11 Dynamic control of allosteric inhibitor specificity
for RGS4. A.J. Storaska, H. Vashitsh and R.R. Neubig. Univ.
of Michigan.
A75
1095.12 Regulator of G-protein signaling 5 reduces
HeyA8 ovarian cancer cell proliferation and extends survival in
a murine tumor model. M.K. Altman, A. Beedle and M. Murph.
Univ. of Georgia.
A76
1095.13 Modulation of regulator of G-protein signaling
4 activity by covalent modification of 4hydroxy-2-nonenal. C.A.
Monroy and D. Roman. Univ. of Iowa.
1096.GPCR CELLULAR SIGNALING AND
PHYSIOLOGY
Poster
Exhibit Halls A-B
A77
1096.1 Non-canonical MMP1-PAR1 signaling drives
vascular smooth muscle cell de-differentiation and restenosis.
K. Austin, G. Javid and A. Kuliopulos. Sackler Sch. of
Biomed. Sci., Tufts Univ. and Tufts Med. Ctr.
A78
1096.2 Role of kallikrein 6-mediated PAR signaling
in astrogliosis. M. Radulovic, H. Yoon, A. Vandell and I.
Scarisbrick. Mayo Clin.
A79
1096.3 Induction of CXCR7 switches SDF-1 signaling
and phagocytic function in macrophages: a potential role in
atherosclerosis. W. Ma, Y. Liu, N. Ellison and J. Shen. Auburn
Univ.
A80
1096.4 GPR124 coupling and function in astrocytomas.
A. Cherry, Y.H. Lin, C. Hague, S-E. Ong and N. Stella. Univ. of
Washington.
A81
1096.5 G-protein coupled receptor profiling: an omics
approach to study receptors and cell signaling. A.S. Wilderman,
A. Snead, F. Murray, N. Aroonsakool and P.A. Insel. UCSD.
A82
1096.6 Repeated cannabinoid administration induces
DFosB and sensitizes mu opioid receptor activity in the nucleus
accumbens. L. Sim-Selley, M. Lazenka, E. Nestler and D.
Selley. Virginia Commonwealth Univ. and Mount Sinai Sch. of
Med.
A83
1096.7 Receptor
mediated
signaling
by
lysophosphatidic acid and epidermal growth factor in a colon
cancer cell line. A.K. Bell, Z. Zhang and K. Meier. Washington
State Univ.
A84
1096.8 Modification of sterol composition in yeast cell
membrane from ergosterol to cholesterol and its effect on Ste2
signaling. K. Kuroda, S. Morioka, T. Shigemori, K. Hara, H.
Morisaska and M. Ueda. Grad. Sch. of Agr., Kyoto Univ.
373
T
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PHARMACOLOGYTUESDAY
A85
1096.9 Lipopolysaccharide-induced
upregulation
of cannabinoid 2 receptors in rat cortical astrocytes. D.N.
Jackson and A. Shivachar. Col. of Pharm. and Hlth. Sci.,
Texas Southern Univ.
A86
1096.10 PKCe-mediated
P-Rex1
downregulation
suppresses breast cancer cell proliferation. C-Y.A. Wong, Y.
Xie, D.W. Wolff, P.W. Abel and Y. Tu. Creighton Univ. Sch. of
Med.
A87
1096.11 CB1 cannabinoid receptors signal through
focal adhesion kinase to activate ERK in neuronal cells. G.D.
Dalton and A.C. Howlett. Wake Forest Sch. of Med.
A88
1096.12 Effect of D3 dopamine receptor signaling
properties on rodent locomotion. S.R. Cote, Y. Li and E.
Kuzhikandathil. Univ. of Med. and Dent. of New Jersey,
Newark.
A89
1096.13 Astrocytes produce nitric oxide in response to
cholinergic or glutamatergic stimulation. X. Wang, A. Lessard,
L-E. Trudeau and H. Girouard. Univ. of Montreal and Univ. of
Maryland Baltimore.
A90
1096.14 Initial characterization of histamine H2-receptor
overexpressing mice. J. Neumann, F. Köhler, U. Kirchhefer, A.
Höft, I. Buchwalow and U. Gergs. Martin Luther Univ. HalleWittenberg, Inst. for Pharmacol. and Toxicol., Münster and
Hematopathol. Inst., Hamburg, Germany.
A91
1096.15 Evidence that the a1L-adrenoceptor is the
native a1A-adrenoceptor in rat vas deferens. J.R. Docherty.
Royal Col. Surgeons Ireland.
A92
1096.16 Neuroblastoma cell proliferation involves
prostaglandin E2 and subsequent b-catenin stabilization. S.
Jansen, J. Van Oppen, I. Hedemann, R. Holman, S. Faraj,
J.W. Kok, S. Diks, W. Timens, R. Gosens, E. De Bont and M.
Schmidt. Univ. of Groningen and Univ. Med. Ctr. Groningen.
A93
1096.17 The 5-HT2A receptor antagonists pizotifen and
cyproheptadine inhibit serotonin-enhanced platelet function. O.
Lin, E.V.P. Espinosa and F.T. Khasawneh. Western Univ. of
Hlth. Sci.
A94
1096.18 Activation of G protein-coupled estrogen
receptor 1 induced coronary vasodilation by activation of MLCP
via cAMP/PKA pathway. X. Yu, F. Li, R.E. White, J.N. Stallone,
C.L. Heaps and G. Han. Texas A&M Univ. and Philadelphia
Col. of Osteo. Med., Suwanee, GA.
1097.CANNABINOIDS
Poster
Exhibit Halls A-B
A95
1097.1 Tolerance and cross-tolerance among highefficacy synthetic cannabinoids JWH-018 and JWH-073 and
low-efficacy phytocannabinoid D9-THC. W.E. Fantegrossi, L.N.
Franks, T. Vasiljevik and P.L. Prather. Univ. of Arkansas for
Med. Sci. and Univ. of Kansas.
A96
1097.2 Possible efficacy related differences among
cannabinoid agonists. G. Chopda, J. Bergman, K. Vemuri,
A. Makriyannis and C.A. Paronis. Northeastern Univ. and
McLean Hosp./Harvard Med. Sch.
A97
1097.3 Interactions between mu opioid receptor
agonists and cannabinoid receptor agonists CP55940 and
WIN55212-2 in rhesus monkeys: evaluation of treatment- and
abuse-related effects. D.R. Maguire, W. Yang and C.P. France.
Univ. of Texas Hlth. Sci. Ctr. at San Antonio.
374
A98
1097.4 Effect of cannabinoid CB2 receptor agonism
on learning and memory in a mouse model of photothrombosis.
A.M. Myers, R.D. Ronca, E.A. Walker, R.F. Tuma and S.J.
Ward. Temple Univ.
A99
1097.5 In search of endocannabinoid degradation
enzymes inhibitors in nutmeg. A.T. El-Alfy, S. Joseph and A.
Brahmbhatt. Chicago State Univ.
A100 1097.6 Discriminative stimulus effects of the synthetic
cannabinoid JWH-018 in rhesus monkeys. J.S. Rodriguez and
L.R. McMahon. Univ. of Texas Hlth. Sci. Ctr. at San Antonio.
A101 1097.7 Inhibition of both FAAH and MAGL, but not
either separately, produces delta-9-THC like discriminative
stimulus effects. L. Hruba, M.J. Niphakis, B.F. Cravatt, A.H.
Lichtman and L.R. McMahon. Univ. of Texas Hlth. Sci. Ctr. at
San Antonio, The Scripps Res. Inst. and Virginia Commonwealth
Univ.
A102 1097.8 A behavioral assessment of the aversive
properties of delta-9-THC in Fischer-Lewis rats. A. Presley
and A. Riley. American Univ.
A103 1097.9 Cannabidiol attenuates the long lasting
cognitive deficits and anxiogenic-like behaviors promoted by
murine cerebral malaria. A.C. Campos, A.S. Miranda, F. Brant,
N.P. Rocha, F.S. Machado, M.A. Rachid, F.S. Guimarães
and A.L. Teixeira. Fed. Univ. of Minas Gerais, Sch. of Med. of
Ribeirão Preto and Univ. of São Paulo.
A104 1097.10 Effects of anandamide and other CB1 ligands
on cognitive function. B.D. Kangas and J. Bergman. Harvard
Med. Sch./McLean Hosp.
1098.STIMULANTS II
Poster
Exhibit Halls A-B
A105 1098.1 The effects of tropisetron on cocaine-induced
conditioned taste aversions. M. Briscione, K. Serafine,
A. Merluzzi, K. Rice and A. Riley. American Univ., Univ. of
Texas Hlth. Sci. Ctr. at San Antonio and NIDA and NIAAA, NIH,
Baltimore.
A106 1098.2 Stereoselective effects of methcathinone on
intracranial self-stimulation in rats. J.S. Bonano, M.L. Banks,
R.A. Glennon and S.S. Negus. Virginia Commonwealth Univ.
A107 1098.3 Attenuation of cocaine-induced behaviors by
the sigma receptor ligand YZ-185. A.S. Sage, K-H. Fan, J.R.
Lever, S.Z. Lever and D.K. Miller. Univ. of Missouri-Columbia.
A108 1098.4 Effects of chronic amphetamine treatment
on cocaine-induced facilitation of intracranial self-stimulation
in rats. C.T. Bauer, M.L. Banks and S.S. Negus. Virginia
Commonwealth Univ. Sch. of Med.
A109 1098.5 Loss of sensitivity to varenicline in monkeys
receiving chronic nicotine treatment. C.S. Cunningham and
L.R. McMahon. Univ. of Texas Hlth. Sci. Ctr. at San Antonio.
A110 1098.6 Punishment by intravenous nicotine in rats.
Y.N-T. Truong and J. Woods. Univ. of Michigan.
A111 1098.7 Physical dependence liability of nicotine in
mice—possible involvement of endogenous opioid system
located on the downstream of a 7 nicotinic acetylcholine
receptor. S. Kishioka, N. Kiguchi, Y. Kobayashi, N. Wakida
and C. Yamamoto. Wakayama Med. Univ., Japan.
TUESDAYPHARMACOLOGY
A112 1098.8 Anatabine significantly decreases nicotine
self-administration. N.K. Mello, P.A. Fivel, S.J. Kohut and S.B.
Caine. McLean Hosp., Harvard Med. Sch.
A113 1098.9 Further characterization of varenicline and
mecamylamine and effects on self-administration of cocaine
and nicotine. S.A. Kromrey, S. Nader and M. Nader. Wake
Forest Sch. of Med.
A114 1098.10 Discriminative-stimulus
effects
of
3,4-methylenedioxy-N-methylamphetamine (MDMA) and a
novel MDMA quatenary analog. J.M. Slezak, M. Mueller, G.A.
Ricaurte, J. Cao, A.H. Newman and J.L. Katz. NIDA, NIH,
Baltimore and Johns Hopkins Sch. of Med.
A115 1098.11 Cocaine-induced locomotor activity in rats
selectively-bred for high and low motivation to voluntarily
run. J.D. Brown, C. Green, D. Miller and F. Booth. Univ. of
Missouri-Columbia.
A116 1098.12 Effects of two-week chronic treatment with
phendimetrazine on choice between cocaine and food in
rhesus monkeys. M.L. Banks, B.E. Blough and S.S. Negus.
Virginia Commonwealth Univ. and Res. Triangle Inst.
A117 1098.13 A comparison of the subjective and
cardiovascular effects produced by exposure to intravenous
versus smoked methamphetamine in the laboratory. J.J.
Mahoney, C. Haile, T. Newton, B. Shapiro and R. De La
Garza. Baylor Col. of Med.
A118 1098.14 Modulation of the discriminative-stimulus
effects of cocaine by dopamine b-hydroxlyase inhibitors in rats.
D.F. Manvich, L. DeBrouse and D. Weinshenker. Emory Univ.
A119 1098.15 Behavioral effects of quinpirole on schedulecontrolled responding in radiation sensitive and insensitive rats.
C.M. Davis and R.D. Hienz. Johns Hopkins Univ. Sch. of Med.
A120 1098.16 Discriminative stimulus effects of direct- and
indirect-acting dopamine receptor agonists in free-feeding and
food-restricted mice. G.T. Collins, J.A. Jackson, C. Henson,
W. Koek and C.P. France. Univ. of Texas Hlth. Sci. Ctr. at San
Antonio.
A121 1098.17 Differential expression of MDPV-induced
taste aversions and thermoregulation in adolescent and adult
rats. A.P. Merluzzi, Z. Hurwitz, M. Briscione, J. Cobuzzi, B.
Wetzell, K. Rice and A. Riley. American Univ. and NIDA, NIH.
A122 1098.18 Eating high fat chow selectively impacts
sensitivity to drugs acting on dopamine D3/D2 but not serotonin
2A receptors. K.M. Serafine and C.P. France. Univ. of Texas
Hlth. Sci. Ctr. at San Antonio.
1099.MOOD DISORDERS
Poster
Exhibit Halls A-B
A123 1099.1 Unraveling mechanisms contributing to lack
of antidepressant efficacy in juveniles and adolescents. N.C.
Mitchell, R.E. Horton, M. Vitela, G.G. Gould, W. Koek and
L.C. Daws. Univ. of Texas Hlth. Sci. Ctr. at San Antonio.
A124 1099.2 The role of hippocampal a2-containing GABAA
receptors in benzodiazepine-induced anxiolysis. E. Engin, K.S.
Smith, R. Keist, F. Crestani, J-M. Fritschy and U. Rudolph.
Harvard Med. Sch./McLean Hosp. and Univ. of Zurich.
A125 1099.3 Optogenetic and pharmacological activation of
beta-adrenergic receptor signaling in the basolateral amygdala
promotes anxiety and aversive behavior. E.R. Siuda, R. AlHasani, J.G. McCall, S.D. Chang, S.L. Anderson and M.R.
Bruchas. Washington Univ. in St. Louis.
A126 1099.4 An investigation of metabotropic glutamate
receptor 5 negative allosteric modulators in physiological
and behavioral indicators of anxiety and cognition in rodents.
J. Moon, D. McGinnis, D.L. Smith, R. Graf, Z. Hughes, S.
Grimwood, E. Miller, P. Trapa, C.L. Shaffer and C.J. Siok.
Pfizer Inc., Cambridge, MA.
A127 1099.5 Anti-neuroinflammation and antidepressant
effects of Schisandrin B in mice. C-H. Yeh, M-W. Lin and H-C.
Lin. Chang Jung Christian Univ., Kaohsiung Chang Gung
Mem. Hosp. and Natl. Yang-Ming Univ., Taiwan.
A128 1099.6 Melatonin accelerates the re-entrainment
rate of multiple spontaneous homecage behavioral rhythms
in the C3H/HeN mice. E.B. Adamah-Biassi, I. Stepien, R.L.
Hudson and M.L. Dubocovich. Univ. at Buffalo Sch. of Med.
and Biomed. Sci.
1100.NEUROPSYCHIATRIC DISORDERS
Poster
Exhibit Halls A-B
7:30 AMA129
1100.1 Uncovering interactions between
organic cation transporters and monamine systems:
implications for novel antidepressant therapies. D.M. Apple,
R.E. Horton, M. Vitela, W. Koek and L.C. Daws. Univ. of Texas
Hlth. Sci. Ctr. at San Antonio.
7:31 AMA130
1100.2 The tryptophan hydroxylase 2
polymorphism C2432T mediates mRNA expression and
responses to antidepressant treatment in a sex-specific
manner. B.R. Brookshire and I. Lucki. Univ. of Pennsylvania
Sch. of Med.
7:32 AMA131
1100.3 Reduction in peripheral blood beta
arrestin1 levels during major depressive disorder in reproductive
women. T. Nayyar, F. Alam, W. Richie, T.A. Ansah and R.K.
Bailey. Meharry Med. Col.
7:33 AMA132
1100.4 Effects of duloxetine in rats trained to
discriminate between 22 and 2 hours food deprivation. M.A.
Vanden Avond, A.R. Johnson, K.A. Reed, M.M. Savickas,
D.J. Nemec, A.T. Schultz, E.J. Hendrickson, N.K. Takle, C.A.
Toddes, A.L. Lucas, B.N. Shattuck, A.P. Halverson, T.J.
Vossen and D.C. Jewett. Univ. of Wisconsin-Eau Claire.
7:34 AMA133
1100.5 Age-related changes in anxietylike behavior modified by expression of a4 subunit containing
nicotinic acetylcholine receptors. S. Anderson and D. Brunzell.
Virginia Commonwealth Univ.
7:35 AMA134
1100.6 High levels of serotonin modulate
oxidative balance in brain’s area related with anxiety behavior?
A.I. da Silva, C. Freitas, L. Nascimento, L.C.M. Galindo, R.
Manhaes-de-Castro, C. Lagranha and S.L. de Souza. Fed.
Univ. of Pernambuco, Recife and Vitoria de Santo Antão, Brazil.
7:36 AMA135
1100.7 Role of oxidative stress in anxietylike behavior and learning and memory impairment in a rat
model of social stress. G. Patki, F. Allam, R. Bohat, F. Jafri, M.
Saleem and S. Salim. Univ. of Houston.
375
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PHARMACOLOGYTUESDAY
7:37 AMA136
1100.8 Chronic administration of the
antipsychotic
olanzapine
dose-dependently
enhances
sleep phenotypes in a rat model of metabolic syndrome. S.
Radzikowski, B.P. Shortal, C.J. Watson, L.G. Koch, S.L.
Britton and H.A. Baghdoyan. Univ. of Michigan.
7:38 AMA137
1100.9 Simultaneous, in vivo monitoring
of 10 neurotransmitters in rat prelimbic cortex reveals that
systemic and local administration of the atypical antipsychotic
olanzapine differentially altered only serotonin levels. C.C.
Norton, O.S. Mabrouk, A. Shatsman, S. Radzikowski, R.T.
Kennedy and H.A. Baghdoyan. Univ. of Michigan.
7:39 AMA138
1100.10 Neuropeptide Y infusion attenuates
development of PTSD-like symptoms to traumatic stress in
rats. L. Serova, A. Tillinger, L.G. Alaluf, M. Laukova and E.L.
Sabban. New York Med. Col.
1101.CLINICAL PHARMACOLOGY
Poster
Exhibit Halls A-B
A139 1101.1 Lost in translation—challenges for academic
scientists in writing clinical protocols. E.M. Seymour, J.
Wright, M. Moore, B. Reisdorph and K. Weatherwax. Univ. of
Michigan.
A140 1101.2 Effect of azelnidipine in human internal
mammary artery and clinical implications. G. Gao, X-Y. Bai, C.
Xuan, X-C. Liu, W-B. Jing, Q. Yang and G-W. He. TEDA Intl.
Cardiovasc. Hosp., Med. Col., Nankai Univ., The Chinese Univ.
of Hong Kong and Oregon Hlth. & Sci. Univ.
A141 1101.3 The occurrence and management of pediatric
poisonings in Lenasia, South Africa. A.Y. Ahmed and S. Moch.
Univ. of Witwatersrand, South Africa.
A142 1101.4 Effect of cilostazol on patients with intermittent
claudication: role of endothelial progenitor cells. T. Tejerina, M.
Ramajo, J. Navarro-Dorado, U. Medina, M.H. Rydings, M.
Perera, E. Puras, F.J. Serrano-Hernando and S. Redondo.
Sch. of Med., Complutense Univ. of Madrid, Clin. Hosp. San
Carlos and Alcorcon Fndn. Hosp., Madrid.
A143 1101.5 Prescription analysis for patients with upper
respiratory tract infections at tertiary referral center in Anand.
K.J. Patel, A. Leuva and A. Rangoonwala. Ramanbhai Patel
Col. of Pharm. and Pramukh Swami Med. Col., India.
1102.TRANSCRIPTIONAL REGULATION OF DRUG
METABOLISM
Poster
Exhibit Halls A-B
A144 1102.1 Transcriptional regulation of human UDPglucuronosyltransferase 2B4 by sulfotransferase deficiency. K.
Barrett, H. Fang, T.A. Kocarek and M. Runge-Morris. Wayne
State Univ.
A145 1102.2 Functional association of hepatocyte nuclear
factor 4 alpha and Krüppel-like factor 9 in cytochrome P450
2D6 regulation during pregnancy. K.H. Koh, X. Pan, A. Yu and
H. Jeong. Col. of Pharm., Univ. of Illinois at Chicago and Univ.
at Buffalo SUNY.
376
A146 1102.3 Induction of CYP2D6 expression during
pregnancy is associated with an increased activity of hepatocyte
nuclear factor 4a. X. Pan, K. Koh, A-M. Yu and H. Jeong. Univ.
of Illinois at Chicago and Univ. at Buffalo SUNY.
A147 1102.4 Induction of cytochrome P450 2E1 expression
by placental lactogen. J.K. Lee, H.J. Chung, X. Pan, M.
Ingelman-Sundberg and H. Jeong. Univ. of Illinois at Chicago
and Karolinska Inst.
A148 1102.5 Aryl hydrocarbon receptor-dependence of
dioxin effects on constitutive mouse hepatic cytochromes P450
and growth hormone signaling components. D.S. Riddick and
C. Lee. Univ. of Toronto.
A149 1102.6 The role of cytochrome P450-dependent
metabolism in the regulation of mouse hepatic growth
hormone signaling components and target genes by
3-methylcholanthrene. D.S. Riddick, C. Lee and X. Ding. Univ.
of Toronto and New York State Dept. of Hlth., Albany.
A150 1102.7 Long noncoding RNAs and transcription of
cytochrome P450s in mouse liver during maturation. L. Peng,
A. Paulson, H. Li, X. He, H. Lu, C.D. Klaassen, L. Li and
X-b. Zhong. Univ. of Connecticut, Univ. of Kansas Med. Ctr.,
Stowers Inst. for Med. Res., MO and SUNY Upstate Med. Univ.
A151 1102.8 17b-Estradiol (E2) induces sulfotransferase
2A1 expression through estrogen receptor a. W. Li, M. Ning, H.
Kim and H. Jeong. Univ. of Illinois at Chicago and Yangzhou
Univ., China.
A152 1102.9 Functional analysis of splice variants of human
constitutive androstane receptor: investigation with flavonol
(3-hydroxyflavone) and its metabolites. A.J. Lau and T.K.H.
Chang. Univ. of British Columbia.
1103.PHARMACOKINETICS/PHARMACODYNAMICS
Poster
Exhibit Halls A-B
A153 1103.1 P-glycoprotein (ABCB1) and breast cancer
resistance protein (ABCG2) restrict the brain penetration of
the Janus family of tyrosine kinase (JAK) inhibitor CYT387. S.
Durmus, N. Xu, R.W. Sparidans, E. Wagenaar, J.H. Beijnen
and A.H. Schinkel. Netherlands Cancer Inst., Amsterdam,
China-Japan Union Hosp., Changchun, China, Utrecht Univ.
Fac. of Sci. and Slotervaart Hosp., Netherlands.
A154 1103.2 Human pharmacokinetics of xanthohumol, a
flavonoid from hops with anti-diabetic activity. L. Legette, R.
Reed, C. Miranda, C. Karnpracha, J.M. Christensen and J.F.
Stevens. Col. of Pharm., Oregon State Univ.
A155 1103.3 A novel method to estimate AF-219 levels
in bladder interstitium derived from drug excreted into the
urine. S.A. Smith, D. Black, D. Song and A.P. Ford. Afferent
Pharmaceuts., San Mateo, CARE Res., Fort Collins and PPL
Lab., Redwood City.
A156 1103.4 Assessing drug interaction risk of the
grapefruit juice component and dietary supplement
6’,7’-dihydroxybergamottin
via
physiologically-based
pharmacokinetic modeling and simulation. G.R. Ainslie, B.T.
Gufford, C.S. Won, K.K. Wolf and M.F. Paine. Eshelman Sch.
of Pharm., Univ. of North Carolina at Chapel Hill.
TUESDAYPHARMACOLOGY
A157 1103.5 Comparative
pharmacokinetics
of
the
complement inhibitor CDX-1135. E. Forsberg, J.M. Boyer,
L.E. Gergel, C.D. Pilsmaker, K.M. Borrelli, S.M. Round, S.R.
Naylor, H.C. Marsh, Jr., T. Keler and L.J. Thomas. Celldex
Therapeut., Needham, MA and Phillipsburg, NJ.
A158 1103.6 Evaluation of oral dabigatran etexilate
pharmacokinetics and pharmacodynamics in hemodialysis
patients. K. Goralski, M. Morrison, P. Mossop, S. Soroka,
D. Anderson and J-A. Wilson. Col. of Pharm., Dalhousie
Univ. and Hlth. Sci. Ctr., Capital District Hlth. Authority, Halifax,
Canada.
A159 1103.7 Contrasting pharmacodynamic requirements
of disease models revealed through characterization of a novel
and selective M1 agonist. M. Wood, G. Martino, M. Coupal,
M. Lindberg, P. Schroeder, V. Santhakumar, M. Valiquette, J.
Sandin, D. Widzowski and J. Laird. AZ Neurosci., Cambridge,
MA.
1104.CANCER PREVENTION
Poster
Exhibit Halls A-B
A160 1104.1 Soluble epoxide hydrolase deficiency inhibits
DSS-induced colitis and carcinogenesis in mice. W. Zhang,
H. Li, H. Dong, J. Liao, B.D. Hammock and G-Y. Yang.
Northwestern Univ., Chicago and Univ. of California, Davis.
A161 1104.2 Curcumin and turmeric as preventive agents
for iron-related carcinogenesis. D.J. Messner, T. Robinson
and K.V. Kowdley. Bastyr Univ. and Benaroya Res. Inst. at
Virginia Mason Hosp., Seattle.
A162 1104.3 Chemopreventive role of metformin during
DMBA–induced breast carcinogenesis inMCF10A cells through
CYP1A1-AhR signaling pathway. Z.H. Maayah, A.A. AlHaider
and H.M. Korashy. King Saud Univ., Saudi Arabia.
A163 1104.4 The preventive and therapeutic efficacy of
finasteride and dutasteride in TRAMP mice. A.B. OpokuAcheampong, D. Unis, A.P. Beck, J. Henningson and B.L.
Lindshield. Kansas State Univ. and Yale Univ. Sch. of Med.
A164 1104.5 miR-627 mediates the epigenetic mechanism
of vitamin D in suppression of colon cancer growth both in vitro
and in vivo. S. Padi and B. Guo. North Dakota State Univ.
A165 1104.6 Pterostilbene inhibits VEGF production in
human breast cancer [MDA-MB-231] cells. A. Sanghani, T.
Kandra, S. Bavadekar and S. Vansal. Long Island Univ. and
Touro Col. of Pharm., NY.
A166 1104.7 Alterations in benzo(a)pyrene induced DNA
damage via organosulfide compounds in MCF-10A cells.
S.F. Darling-Reed, Y. Nkrumah-Elie, A. Hudson, H. FloresRozas, M. Jett, R. Hammamieh, A. Day, E. Oriaku and J.S.
Reuben. Florida A&M Univ., Oregan State Univ., WRAIR, Ft.
Detrick, Howard Univ and Univ. of South Carolina Sch. of Med.
A167 1104.8 GUCY2C hormone deficiency contributes
to diet-induced colorectal tumorigenesis. J.E. Lin, F. ColonGonzalez, G.W. Kim, P. Li, E.S. Blomain, G. Marszalowicz,
B.A. Stoecker and S.A. Waldman. Thomas Jefferson Univ.,
Univ. of Utah and Drexel Univ.
A168 1104.9 Purinergic mechanisms in breast cancer
development: a role for nucleoside diphosphate kinase. S.
Wong, N. Yokdang, K. Speirs and I.L.O. Buxton. Univ. of
Nevada, Reno.
1105.CANCER THERAPEUTICS
Poster
Exhibit Halls A-B
A169 1105.1 Modulated light wave tumor therapy: case
study. O.L. Tulp, G.P. Einstein, T. Chow, M.P. Wnuk and R.
Branly. USAT Col. of Med., Montserrat and Univ of WisconsinMilwaukee.
A170 1105.2 Rock inhibition reduces senescent cell size.
Y.D. Simay, S. Hosbas, B. Ibisoglu, M. Yildiz, A. Ozdemir and
M. Ark. Gazi Univ., Turkey.
A171 1105.3 Apoptotic mechanism of novel anticancer
agents is mediated by MAPKs in breast cancer cells. L.S.
McLean and E. Brantley. Loma Linda Univ.
A172 1105.4 Oncolytic adenoviral therapy enhanced by
targeting cyclin E overexpression and inducing autophagy. P-h.
Cheng, X-M. Rao, K.M. McMasters and H.S. Zhou. Univ. of
Louisville.
A173 1105.5 Alterations
in
the
intracellular
Ca2+
concentration and vimentin in endothelial cells following tumor
cell-endothelial cell interactions. Y. Pan and X. Li. Peking Univ.
A174 1105.6 A new strategy to block tumor angiogenesis
by inhibiting endocannabinoid inactivation. M. El-Azab, R.
Ammar, M. Abdel-Hamid and Y. Moustafa. Suez Canal Univ.,
Sinai Univ. and Al-Azhar Univ., Egypt.
A175 1105.7Withdrawn.
A176 1105.8 The role of 20-HETE in the regulation of
androgen receptor nuclear translocation. Y. Liu, K. Gotlinger
and M. Schwartzman. New York Med. Col.
A177 1105.9 Crude extracts of Antrodia cinnamomea inhibit
invasion and migration of human hepatocellular carcinoma
cells. Y-Y. Chen and M-J. Sheu. China Med. Univ., Taiwan.
A178 1105.10 Celecoxib induces apoptosis by the intrinsic
pathway in HT-29 colon carcinoma and A375 melanoma cells.
R.A. Schneider, K.G. Eckles, V.C. Kelty, L.R. Palmisano, K.A.
Strozewski, J.S. Teckmeyer and D.H. Kinder. Col. of Pharm.,
Univ. of Findlay and Col. of Pharm., Ohio Northern Univ.
A179 1105.11 Epinephrine stimulates secretion of VEGF
by human prostate cancer cells, LNCaP, through a beta2adrenergic receptor-mediated pathway. S. Bavadekar, F.
Budajaja, K. Patel and S. Vansal. Arnold & Marie Schwartz
Col. of Pharm. and Hlth. Sci., Long Island Univ. and Touro Col.
of Pharm., New York.
A180 1105.12 Allicin inhibits metastasis of MCF-7 cells by
inhibition of VCAM-1 expression. C.G. Lee and S. Pyo. Sch. of
Pharm., Sungkeunkwan Univ., South Korea.
A181 1105.13 Small molecule targeting of RhoC-regulated
gene transcription in metastatic, undifferentiated melanoma.
A.J. Haak, S.M. Wade, J.L. Bell, S.D. Larsen, M. Verhaegen,
E.R. Lawlor and R.R. Neubig. Univ. of Michigan.
A182 1105.14 The ameliorative effect of silymarin on
cadmium-treated human lung carcinoma cells. C.A. Webster,
L.M. Latinwo, V.L.D. Badisa, C.O. Odewumi and S.F. DarlingReed. Florida A&M Univ.
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A183 1105.15 Cytoskeletal inhibitor disruption of tunneling
nanotube mediated communication may affect cancer
progression. Y.D. Connor, S. Bhatia, N.K. Gill, S. Tekleab, D.
Bharat and S. Sengupta. Harvard-MIT, Cambridge, Smith Col.
and Brigham and Women’s Hosp.
A184 1105.16 Growth inhibition and radiosensitization of
human papillomavirus positive head and neck cancer by
epidermal growth factor receptor inhibition is mediated by
apoptosis. R.J. Kimple, M.A. Smith, G.C. Blitzer, H-S. Huang
and A.D. Torres. Univ. of Wisconsin-Madison.
A185 1105.17 Selective estrogen receptor modulators
resveratrol, genistein, tamoxifen and pterostilbene downregulate
the expression of estrogen-regulated trefoil factor 1 gene in
MCF-7 breast cancer cells. V.D. Bhatt and W.N. Ratna. Arnold
& Marie Schwartz Col. of Pharm., Long Island Univ.
A186 1105.18 Induction of apoptosis in MCF-7 and NCI/
ADR-RES cells by triazole-containing estradiol analogs. R.A.
Schneider, L.N. Reiff and R.W. Dudley. Univ. of Findlay, OH.
A187 1105.19 Bioenergetic immunostimulation, metabolism,
and nutrition support in lung cancer: a case study. O.L. Tulp,
G.P. Einstein, J. Kowaleski and M. Dancewicz. USATMontserrat, and Nicolaus Copernicus Univ., Poland.
A188 1105.20 The role of reactive oxygen species in the
apoptotic effects of curcumin and simvastatin on lung cancer
cell line. S.H. Lee, I.K. Kim, H.I. Lee, H.Y. Lee, W.H. Ban, S.W.
Kim, H.H. Kang and H.S. Moon. St. Paul’s Hosp., The Catholic
Univ., Seoul.
A189 1105.21 The effect of CBG (BDS) botanical cannabinoid
extract on MCF-7 human breast carcinoma cells. F. Javid and
S. Fshinjavid. Sch. of Applied Sci., Univ. of Huddersfield, U.K.
A190 1105.22 Development of selective inhibitors of the
isoprenoid biosynthetic pathway and their effects on humanderived chronic myelogenous leukemia cells. J.E. Reilly, X.
Zhou, H. Tong, D. Wiemer and R.J. Hohl. Univ. of Iowa.
A191 1105.23 Induction of autophagy by cisplatin-resistant
esophageal cancer cells promotes survival and recovery. L. Yu,
C. Gu and S. Liu. Sch. of Pharmaceut. Sci., Southern Med.
Univ., China.
A192 1105.24 Pro-apoptotic agents induce ATP release from
leukemia/ lymphoma tumor cells via pannexin-1 dependent
and pannexin-1-independent mechanism. A.M. Boyd-Tressler
and G.R. Dubyak. Case Western Reserve Univ.
A193 1105.25 Modulation of indoleamine 2,3-dioxygenase
pathway by a combination therapy strategy targeting myeloid
derived suppressor cell function in lung cancer. C. Schafer,
T.H. Jin, A. Sawant, J. Roth, S. Grant, S. Ponnazhagan and
J. Deshane. Univ. of Alabama at Birmingham.
A194 1105.26 Cyclin D2-mediated cardiomyocyte cell cycle
activity reverses doxorubicin-induced cardiotoxicity. W. Zhu,
M.H. Soonpaa, W. Zhang, W. Shou, R.M. Payne and L.J.
Field. Indiana Univ. Sch. of Med.
A195 1105.27 Prevention of cyclophosphamide-induced
alopecia by selegiline in a murine model. M.D. Berry, A.C.
Gaiser, S.I. Chapman and P. Jackson. Brandon Univ.,
Canada.
A196 1105.28 Differential effects of cisplatin on lung cancer
cells and primary neurons: roles of small GTPase RhoA. Z.
Weng, A. Friesland, Z. Lu, Y-H. Chen, F.M. Longo, C. Boykin
and Q. Lu. East Carolina Univ. and Stanford Univ.
A197 1105.29 Role of RhoA in cisplatin–induced neurotoxicity.
A.M. Friesland, M. Duenas, Z. Weng, F.M. Longo, Y-H. Chen
and Q. Lu. East Carolina Univ. and Stanford Univ.
378
A198 1105.30 Selective growth inhibition of human malignant
melanoma cells by syringic acid-derived proteasome inhibitors.
M-S.I. Abaza, K. Orabi, K. El Sayed, A. Elnagar, R. Al-Attiyah
and R. Guleri. Kuwait Univ., Univ. of Louisiana at Monroe and
Univ. of Southern California.
1106.HEPATOTOXICITY
Poster
Exhibit Halls A-B
A199 1106.1 Secreted factors of Lactobacillus rhamnosus
GG culture prevents chronic alcohol-induced liver injury. Y.
Wang, C. Wang, C. Wang, M. Zhang, Y. Liu, C. McClain and
W. Feng. Univ. of Louisville and Louisville VA Med. Ctr.
A200 1106.2 S-adenosyl-L-methionine (SAMe) protects
the liver from acetaminophen (APAP) protein modifications
due to oxidative stress. A.B. Lamyaithong, J.M. Brown, J.G.
Ball, J. Wolfe and M.A. Valentovic. Wheeling Jesuit Univ. and
Marshall Univ.
A201 1106.3 The
role
of
choline
depletion
in
perfluorooctanesulfonate-induced
hepatic
steatosis. P.
Krishnan, A.D. Patterson, D.J. Ehresman, P.B. Smith, M.K.
Scavello, S-C. Chang, J.L. Butenhoff and J.M. Peters. Penn
State and 3M Co.
A202 1106.4 Potentiation of cytotoxicity by two metabolites
of 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione in HepG2 cells.
S. Ejaz, R. Tchao and P.J. Harvison. Univ. of the Scis. in
Philadelphia.
A203 1106.5 Zinc oxide nanparticles induce apoptosis
and necrosis in hepatocellular carcinoma HepG2 cells. S.M.
Tadinada, M.B. Lai, V. Idikuda, K. Mukka, R.M. Singh, J.
Pfau, A. Bhushan, S. Leung and J.C.K. Lai. Idaho State Univ.
A204 1106.6 The possible antidotal effect of alpha-lipoic
acid against acetaminophen-induced hepatotoxicity in rats.
M.A. El-Moselhy, S.M. El-Shazly and W.A. Barakat. Fac. of
Pharm., Minia Univ. and Zagazig Univ., Egypt.
A205 1106.7 Effects of fluoxetine and aspirin on bleeding
time and liver when used alone or in combination in rats. S.
Shrestha and N. Sookvanichsilp. Mahidol Univ., Thailand.
A206 1106.8 Induction of neuronal nitric oxide synthase in
livers of mice treated with toxic doses of acetaminophen. R.
Agarwal, S. Banerjee and J.A. Hinson. Univ. of Arkansas for
Med. Sci.
A207 1106.9 Activation of autophagy by globular adiponectin
attenuates ethanol-induced apoptosis in HepG2 cells. S. Nepal,
M.J. Kim, A. Subedi and P-H. Park. Col. of Pharm., Yeungnam
Univ., South Korea.
A208 1106.10 Alcohol exposure increases fibroblast growth
factor 21 expression. C. Zhao, Y. Liu, C. McClain and W. Feng.
Univ. of Louisville and Louisville VA Med. Ctr.
A209 1106.11 Fibroblast growth factor 21 is required for
alcohol-induced adipose tissue lipoatrophy in mice. Y. Liu, C.
Zhao, Y. Wang, C. McClain and W. Feng. Univ. of Louisville
and Louisville VA Med. Ctr.
TUESDAYPHARMACOLOGY
1107.PULMONARY PHARMACOLOGY AND
TOXICOLOGY
Poster
Exhibit Halls A-B
A210 1107.1 Olaparib, a PARP inhibitor approved for
human testing, prevents allergen-induced airway inflammation
and hyperresponsiveness in a mouse model of asthma and
reduces proliferation of human CD3/C28-stimulated CD4+ T
cells. M.A. Ghonim, A.S. Naura, P. Rodriguez, A. Al Khami,
C. Hernandez, M.S. Mansy, A. Ochoa and H. Boulares. LSU
Sch. of Med., New Orleans and Fac. of Pharm., Al-Azhar Univ.,
Egypt.
A211 1107.2 Validation of an early life candidate biomarker
for childhood asthma. H. Xu, T. Radabaugh, Z. Lu, D.
Billheimer, D. Vercelli, M. Halonen and S.S. Lau. Univ. of
Arizona.
A212 1107.3 Genetic influences in the development of
amiodarone-induced pulmonary fibrosis. M. Hartog, B. Herron,
D. Lawrence and X. Ding. New York State Dept. of Hlth. and
Sch. of Publ. Hlth., SUNY at Albany.
A213 1107.4 Acetaminophen at low doses depletes airway
glutathione and alters respiratory reflex responses. G.J. Smith,
J.A. Cichocki, J.E. Manautou and J.B. Morris. Univ. of
Connecticut.
A214 1107.5 Role of biased signaling by beta-blockers in
the development of asthma phenotype in a murine model.
V.J. Thanawala, G. Forkuo, N. Al-Sawalha, B. Knoll, P. Leff
and R. Bond. Univ. of Houston and Pharmaceut. Consultant,
Cheshire, U.K.
A215 1107.6 Role for A-kinase anchoring proteins in
cigarette smoke-induced barrier dysfunction. A. Oldenburger,
W. Poppinga, F. Kos, W. Rijks, I. Heijink, W. Timens, H. Meurs,
H. Maarsingh and M. Schmidt. Univ. Med. Ctr. Groningen,
Netherlands.
A216 1107.7 Epac2 and PLCe contribute to the inflammatory
response to cigarette smoke in vivo. A. Oldenburger, S. Bos,
A. Smrcka, H. Meurs, H. Maarsingh and M. Schmidt. Univ. of
Groningen, Netherlands and Univ. of Rochester Sch. of Med.
A217 1107.8 Effects of dabigatran on bleomycin-induced
pulmonary toxicities and its safety profile in mice. N. Shrestha
and N. Sookvanichsilp. Mahidol Univ., Thailand.
POSTER PRESENTERS:
UPLOAD YOUR POSTER
Where:E-Poster Counter, Sun. – Tue. Hall A;
Wed. Hall C
Deadline:Tue., April 23, 5:00 pm
Wed., April 24, 3:00 pm
Uploaded posters will be available online to
all registered attendees following the meeting
at www. experimentalbiology.org
A218 1107.9 Sphingolipid biosynthesis and inflammatory
signaling in asthma. S. Ramachandran, A. Engel, G. Barton
and J. Thorner. Univ. of California, Berkeley.
A219 1107.10 Follistatin-like 1 enhances cigarette smokeinduced interleukin-8 secretion from human airway smooth
muscle cells. H. Cernecka, W.J. Poppinga, S.R. Jansen, M.
Schmidt, M.J.B. van den Hoff and H. Maarsingh. Univ. of
Groningen, Netherlands and Acad. Med. Ctr., Amsterdam.
A220 1107.11 Therapeutic efficacy of MJ33, a novel inhibitor
of phospholipase A2 of peroxiredoxin 6, in LPS-induced acute
lung injury. I. Lee, C. Dodia, S. Chatterjee, S.I. Feinstein and
A.B. Fisher. Univ. of Pennsylvania.
A221 1107.12 Differential expression of renin-angiotensin
system components in the choroid plexus of betamethasone
exposed and control sheep. A.C. Marshall, H.A. Shaltout, N.T.
Pirro, J.C. Rose, D.I. Diz and M.C. Chappell. Wake Forest
Sch. of Med. and Sch. of Pharm., Alexandria Univ., Egypt.
A222 1107.13 Pharmacological
evaluation
of
Cissus
quadrangularis fractionated extracts for bronchodilatory activity
using guinea pigs. S.D. Patil and N.K. Kumavat. R.C. Patel
Inst. of Pharmaceut. Educ. and Res., Shirpur, India.
A223 1107.14 Influence
of
hepatic
P450-mediated
amiodarone metabolism on amiodarone-induced pulmonary
toxicity. M. Hartog, Y. Zhu, D. Lawrence, B. Herron and X.
Ding. New York State Dept. of Hlth. and Sch. of Publ. Hlth.,
Univ. at Albany SUNY.
A224 1107.15 Nerve growth factor reduces amiloridesensitive Na+ transport in human airway epithelial cells. M.J.
Shimko, E.J. Zaccone, J.A. Thompson, D. Schwegler-Berry,
P.A. Willard and J.S. Fedan. West Virginia Univ. and NIOSH.
A225 1107.16 Effects of popcorn butter flavorings, diacetyl
and 2,3-pentanedione, on isolated airway preparations. E.J.
Zaccone, J.A. Thompson, M.J. Shimko and J.S. Fedan.
West Virginia Univ. and NIOSH.
A226 1107.17 The role of the b2-adrenoceptor Gs pathway in
the development of the asthma phenotype in murine models.
G.S. Forkuo, V.J. Thanawala, N. Sawalha, B. Knoll and R.
Bond. Univ. of Houston.
A227 1107.18 Informed target discovery for gene and stem
cell therapy in acute lung injury. D.Y. Zhou, H. Amatullah, Y.X.
Shan, P. Gali, P.Z. Hu and C.C. dos Santos. Univ. of Toronto.
A228 1107.19 Losartan improves impaired vascular and
endothelial responses in mice with allergic asthma. D.S.
Ponnoth and S.J. Mustafa. West Virginia Univ.
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379
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PHYSIOLOGYTUESDAY
Physiology
1108.HYPERTENSION III
Poster
Exhibit Halls A-B
B1
1108.1 Autophagy in RLVM mediates ER stressassociated neurogenic hypertension in SHR. Y-M. Chao, J.Y.H.
Chan and S.H.H. Chan. Chang Gung Mem. Hosp.-Kaohsiung
Med. Ctr. and Natl. Cheng Kung Univ., Taiwan.
B2
1108.2 Decreased transglutaminase activity in aorta
from hypertensive rats, measured by in situ detection of a free
amine donor. H.G. Petersen-Jones, K.B. Johnson and S.W.
Watts. Michigan State Univ.
B3
1108.3 Effects of ethanol extract of Gastrodia elata
Blume on high-fructose induced metabolic syndrome. M.C.
Kho, Y.J. Lee, Y.M. Ahn, Y.H. Choi, A.Y. Kim, D.G. Kang and
H.S. Lee. Wonkwang Univ., South Korea.
B4
1108.4 Time course of changes in sympathetic nerve
activity during development of hypertension in spontaneously
hypertensive rats. N. Mineyama, M. Yoshimoto, M. Shirai and
K. Miki. Nara Women’s Univ. and Natl. Cardiovasc. Ctr., Osaka.
B5
1108.5 The balance between neural and hemodynamic
factors is abolished in hypertensive men. E. Hart, A. Burchell,
L. Ratcliffe, A. Baumbach, A. Nightingale and J.F.R. Paton.
Sch. of Clin. Sci. and Bristol Heart Inst., Univ. of Bristol.
B6
1108.6 2,4,3´,5´-Tetramethoxystilbene reduces blood
pressure and associated cardiac fibrosis via inhibition of
cytochrome P450 1B1 and decreased oxidative stress in SHR.
B.L. Jennings, D.E. Montanez, A.M. Estes, F.A. Yaghini and
K.U. Malik. Univ. of Tennessee, Memphis.
B7
1108.7 Carotid body denervation stunts development
of Goldblatt 2 kidney-1 clip hypertension in adult rats. F.D.
McBryde, A.P.L. Abdala, E.B. Hendy and J.F.R. Paton. Univ.
of Bristol.
B8
1108.8 Tissue-specific regulation of CB1/CB2 gene
receptors in salt-sensitive hypertension of SHR. J. Varagic and
P.E. Gallagher. Wake Forest Univ.
B9
1108.9 Angiotensin II-induced hypertension results in
an oligioclonal T cell receptor expansion in mouse kidney. D.W.
Trott, C-I. Li, Y. Shyr and D.G. Harrison. Vanderbilt Univ. Med.
Ctr.
1109.DIABETES AND INSULIN RESISTANCE III
Poster
Exhibit Halls A-B
B10
1109.1 Effects of aerobic exercise training on obese
female mice: metabolic and autonomic evaluation. M. Sartori,
L.E. de Souza, P.R. de Souza, F. Santos, K. De Angelis and
M.C. Irigoyen. Heart Inst. and Fac. of Med., Univ. of São Paulo
and Nove de Julho Univ., Brazil.
380
B11
1109.2 Metabolic
reprogramming
and
miRNA
expression profile in liver of prenatally dexamethasone-treated
rats. L.C. Pantaleão, L.R.B. Santos, L. Sakamoto, C. LellisSantos, P.R.L. Gomes, S.C. Rodrigues, M.Q. Latorraca and
S. Bordin. Univ. of São Paulo and Fed. Univ. of Mato Grosso,
Brazil.
B12
1109.3 Methyl-b-cyclodextrin
increases
GLUT4mediated glucose transport in skeletal muscle fibers from
insulin-resistant mice. P. Llanos, A. Contreras-Ferrat, C.
Osorio-Fuentealba, A. Espinosa, J. Hidalgo, C. Hidalgo and
E. Jaimovich. Univ. of Chile, Chile and ICBM, Santiago.
B13
1109.4 The upregulation of skeletal muscle
inflammatory genes links inflammation with impaired insulin
resistance in women with the metabolic syndrome. M.T.E.
Hopman, G. Lammers, F. Poelkens and C.J. Tack. Radboud
Univ. Nijmegen Med. Ctr., Netherlands.
B14
1109.5 Obesity and insulin resistance in adolescents:
impact of renin angiotensin system. F.B. Fernandes, A.B.
Fernandes, A.C. da Silva Febba, M.S. de Souza Vitale, F.F.
Jung and D.E. Casarini. Fed. Univ. of São Paulo, Presbyterian
Mackenzie Univ. and Camilo Castelo Branco Univ., Brazil.
B15
1109.6 Induced pulp lesion promotes alteration of the
insulin signal and causes insulin resistance. D.H. Sumida, R.D.
Astolphi, M.M. Curbete, F.Y. Chiba, A.P. Yamamoto, A.K.C.
Prieto and L.T.A. Cintra. São Paulo State Univ., Araçatuba.
B16
1109.7 Chronic treatment with NaF promotes
dyslipidemia in rats. D.H. Sumida, C.A.S. Garbin, N.H.
Colombo, R.D. Astolphi and F.Y. Chiba. São Paulo State
Univ., Araçatuba.
B17
1109.8 Effect of milk consumption and the glycemic
response on healthy college aged subjects. T.M. Fodstad, K.C.
Ackermann and T. Wilson. Winona State Univ.
B18
1109.9 BXD mouse lines as a genetic reference
population for metabolic syndrome. S. Lamy. EPFL, Lausanne.
B19
1109.10 Muscle-specific deletion of mTORC2 (Rictor)
blocks insulin stimulated Akt Ser 473 phosphorylation and
impairs submaximal but not maximal insulin induced glucose
uptake. M. Kleinert, L. Sylow, T.E. Jensen, A-J. Oxboll and E.
Richter. Univ. of Copenhagen.
1110.RENAL HEMODYNAMICS AND GFR
Poster
Exhibit Halls A-B
B20
1110.1 Rho kinase inhibition counteracts tyrosine
kinase inhibitor-induced rise in arterial pressure and renal
vascular resistance. O. Grisk, T. Meissner, A. Donner, D.
Braun, U. Zimmermann and R. Rettig. Univ. of Greifswald,
Germany.
B21
1110.2 Acute renal medullary interstitial infusion of
either saline or 2% albumin indistinctly rises RIHP and RMBF
in the rat. M.E. Sánchez-Briones, J.F. López-Rodríguez,
M.Z. Calvo-Turrubiartes and M. Rodríguez-Martínez.
Autonomuos Univ. of San Luis Potosí, Mexico.
TUESDAYPHYSIOLOGY
B22
1110.3 The
a2-adrenoceptor
agonist,
dexmedetomidine, elicits pronounced decreases in arterial
blood pressure and renal hemodynamics in Cyp1a1-Ren2
transgenic rats with angiotensin II-dependent malignant
hypertension. C.K. Thorngren, M.E. Patterson, P.D. Davis
and K.D. Mitchell. Tulane Univ. and Ochsner Hlth. Syst., New
Orleans.
B23
1110.4 Role of connexin 45 in the autoregulatory
response of the afferent arteriole. C.M. Sorensen, T.H.
Braunstein and N-H. Holstein-Rathlou. Univ. of Copenhagen.
B24
1110.5 Nephrovascular interactions in a mathematical
model of rat renal autoregulation. I. Sgouralis and A. Layton.
Duke Univ.
B25
1110.6 Sequential assessment of glomerular filtration
rate during development of hypertension in freely moving Dahl
salt-sensitive rats. A.W. Cowley, Jr., R.P. Ryan, T. Kurth, D.
Schock-Kusch and N. Gretz. Med. Col. of Wisconsin and Univ.
of Heidelberg, Mannheim.
B26
1110.7 N-acetyl-seryl-aspartyl-lysyl-proline
(AcSDKP) prevents the progression of renal dysfunction in mice
with lupus (MRL/lpr). T-D. Liao, P. Nakagawa, M. D’Ambrosio,
N-E. Rhaleb, X-P. Yang and O. Carretero. Henry Ford Hosp.
B27
1110.8 Resveratrol induces acute endotheliumdependent renal vasodilation. K.L. Gordish and W.H.
Beierwaltes. Wayne State Univ. and Henry Ford Hosp.
B28
1110.9 Switch from ACE to chymase mRNA expression
in diabetes in enriched renal vascular tissues harvested by
manual sieving. S.M. Ford, P.M. Berner and L.M. HarrisonBernard. LSU Hlth. Sci. Ctr., New Orleans.
B29
1110.10 The role of nitric oxide in pericyte-mediated
regulation of vasa recta diameter. C. Crawford, J.S. Pollock,
S.S.P. Wildman and C.M. Peppiatt-Wildman. Medway Sch. of
Pharm., Univs. of Kent and Greenwich, U.K. and Med. Col. of
Georgia.
B30
1110.11 Telemetry-based oxygen sensor to continuously
monitor renal cortical oxygenation in the conscious rat. M.P.
Koeners, C.P.C. Ow, R.G. Evans, D.M. Russell, J.A. Joles
and S. Malpas. Univ. of Auckland, New Zealand, Univ. Med.
Ctr. Utrecht, Netherlands, Monash Univ., Australia and Millar
Instruments, Auckland.
B31
1110.12 Serine proteases affect in situ vasa recta
capillary diameter: mechanism for kidney failure associated
with pancreatitis? R. Birch, C. Crawford, M. Kelly, R.J. Unwin,
E. Schwiebert, S.S.P. Wildman and C.M. Peppiatt-Wildman.
Medway Sch. of Pharm., Univs. of Kent and Greenwich, UCL
Med. Sch., Royal Free Hosp., London and DiscoveryBiomed
Inc., Birmingham, AL.
B32
1110.13 A novel role for GABA and glutamate in
pericyte-mediated regulation of medullary blood flow. K.N.
Dunn, S.P. Kelley, C. Crawford, S.S.P. Wildman and C.M.
Peppiatt-Wildman. Medway Sch. of Pharm., Univs. of Kent
and Greenwich, U.K.
B33
1110.14 Inhibition of NADPH oxidase improves renal
autoregulation in rats fed a high salt diet. R.C. Fellner, M.I.
Giddens and E.W. Inscho. Georgia Hlth. Sci. Univ.
B34
1110.15 Attenuated contractility in afferent arterioles
during development of proteinuria in two-kidney, one-clip
hypertensive rats. T.D. Dahl, T. Skogstrand, F. Helle, M.
Hultström, O. Tenstad and B.M. Iversen. Univ. of Bergen,
Norway, Univ. of Uppsala, Sweden and Haukeland Univ. Hosp.,
Bergen.
B35
1110.16 Renal autoregulation dynamics monitored
across the renal surface. C. Scully, N. Mitrou, B. Braam, W.
Cupples and K. Chon. Worcester Polytech Inst., Simon Fraser
Univ., Canada and Univ. of Alberta.
B36
1110.17 A pivotal role for pericytes in non-steroidal antiinflammatory drug-induced toxicity. C.M. Peppiatt-Wildman,
T. Kennedy-Lydon, C. Crawford and S.S.P. Wildman.
Medway Sch. of Pharm. and Royal Vet. Col., Univs. of Kent and
Greenwich, U.K.
B37
1110.18 Renal ischemia-reperfusion led to enhanced
renal microvascular response to sphingosine-1-phosphate.
Z. Guan, S.T. Singletary, J. Van Beusecum, A.K. Cook and
E.W. Inscho. Georgia Hlth. Sci. Univ.
B38
1110.19 Potential sex differences in the vascular
endothelial growth factor signaling pathway in the kidney. A.
Rouch and L. Fan. Oklahoma State Univ. Ctr. for Hlth. Sci.
B39
1110.20 Acute podocyte injury enhances the
susceptibility to blood pressure-induced injury in rats with
underlying ¾ renal mass reduction. A.J. Polichnowski,
M.M. Picken, K.A. Griffin and A.K. Bidani. Hines VA Hosp.
and Loyola Univ. Chicago, Hines and Loyola Univ. Chicago,
Maywood.
B40
1110.21 Renal autoregulation is not impaired during
early streptozotocin diabetes mellitus in Long-Evans rats. N.
Mitrou, F. Hansen, S. Morrison, P. Mousavi, C. Hong and W.
Cupples. Simon Fraser Univ., Canada.
B41
1110.22 Macula densa nitric oxide contributes to
anomalous tubuloglomerular feedback in subtotal nephrectomy
rats on high salt diet. P. Singh, H. Pham, S. Khang and S.
Thomson. UCSD and VA San Diego Healthcare Syst. and
O’Brien Core Ctr., San Diego.
B42
1110.23 ADP-ribosyl cyclase (CD38) and superoxide
mediate renal vasoconstriction due to thromboxane receptor
(TpR) activation. N. Moss, T. Kopple and W. Arendshorst.
Univ. of North Carolina at Chapel Hill.
B43
1110.24 Connecting tubule glomerular feedback in
Dahl salt-sensitive and spontaneously hypertensive rats.
M.A. D’Ambrosio, H. Wang, J.L. Garvin, Y. Ren and O.A.
Carretero. Henry Ford Hosp.
B44
1110.25 Electroacupuncture and moxibustion hinder
the progression of renal disease by modulating systemic and
renal renin-angiotensin system. M.A. Naves, J.C. Paterno,
Z.P. Jara, F.B. Fernandes, D.E. Casarini, E.O. Sales and V.P.
Teixeira. Fed. Univ. of São Paulo.
1111.RENAL WATER TRANSPORT, UREA
TRANSPORT AND COUNTERCURRENT
MECHANISMS
Poster
Exhibit Halls A-B
B45
1111.1 A novel small-molecule urea transporter
inhibitor acts as a potential diuretic. B. Yang, F. Li, T. Lei and H.
Zhou. Peking Univ.
B46
1111.2 Modeling the effects of medullary blood flow
regulation on pressure natriuresis. R. Moss and A. Layton.
Duke Univ.
381
T
U
E
PHYSIOLOGYTUESDAY
B47
1111.3 Protein carbamylation is a physiological posttranslational modification in the renal inner medulla. J.S.
Claxton, G. Liu, P.C. Sandoval, C-L. Chou and M.A. Knepper.
NHLBI, NIH.
B48
1111.4 Increased UT-A1 ubiquitination is partially due
to decreased deubiquitination activity in streptozotocin-induced
diabetic rat kidney inner medulla. H. Su, T.O. Ilori, J.D. Klein,
J.M. Sands and G. Chen. Emory Univ.
B49
1111.5 Quantitative proteomics of hypokalemia
induced nephrogenic diabetes insipidus. S. Khositseth, P.
Somparn, P. Uawithya and S-H. Chen. Thammasat Univ.,
Chulalongkorn Univ. and Mahidol Univ., Thailand and Natl.
Cheng Kung Univ., Taiwan.
B50
1111.6 Membrane mobility of aquaporin-2 tagged with
photoconvertible fluorescence protein in mpkCCD cells. K-P.
Yip, J. Amin, C-M. Tse and B. Cha. Univ. of South Florida and
Johns Hopkins Univ.
B51
1111.7 Progressive increase in collecting duct basal/
apical AQP2 expression ratio with increasing depth along the
corticopapillary axis positively correlates with maximum urine
concentrating capacity. M. Espineira, R.L. Gilbert and T.L.
Pannabecker. Univ. of Arizona.
B52
1111.8 Genetic ablation of aquaporin-2 in the mouse
connecting tubules results in defective renal water handling.
M.L.A. Kortenoeven, N.B. Pedersen, R.L. Miller, A. Rojek
and R.A. Fenton. Aarhus Univ., Denmark and Univ. of Utah.
B53
1111.9 Computer modeling of peristaltic contraction
and solute concentration in 3D inner medulla of the rat. P. Lee
and D. Beard. Med. Col. of Wisconsin.
B54
1111.10 Rapamycin, an inhibitor of mTOR signaling
pathway, reverses lithium-induced cell proliferation in renal
collecting ducts. Y. Gao, J. Romero-Aleshire, Q. Cai, T.J.
Price and H.L. Brooks. Univ. of Arizona.
B55
1111.11 Dialysis efficacy at rest and during intra-dialytic
exercise: agreement between serum and online Kt/V. C. Getz,
T. Parsons, R. Morton, E. Toffelmire and C. King-VanVlack.
Queen’s Univ., Canada.
B56
1111.12 Outer medullary Na-K-ATPase activity and
protein expression levels of the highly concentrating kangaroo
rat exceed those of Sprague-Dawley or Munich-Wistar rats.
T.M. Armstrong, M. Shahidullah and T.L. Pannabecker. Univ.
of Arizona.
B57
1111.13 Prox1 expression in the ascending thin limb of
Henle’s loop is regulated by osmolality. J. Kim, Y-M. Kim, W-Y.
Kim and S-A. Nam. The Catholic Univ. of Korea.
B58
1111.14 Urea permeabilities in defined segments of rat
renal inner medullary thin limbs of Henle’s loops. K.K. Evans,
T.L. Pannabecker and W.H. Dantzler. Univ. of Arizona.
B59
1111.15 Gene expression in the thin limbs of Henle of
the water-restricted rat. C.M. Nawata, W.H. Dantzler and T.L.
Pannabecker. Univ. of Arizona.
B60
1111.16 RNA-Seq analysis of glycosylation related
gene expression in streptozotocin-induced diabetic rat kidney
inner medulla. G. Chen, X. Li, H. Su, T.O. Ilori, J.D. Klein and
R.P. Hughey. Emory Univ. and Univ. of Pittsburgh Sch. of Med.
B61
1111.17 Transgenic mice expressing UT-A1, but lacking
UT-A3, have intact urine concentrating ability. J.D. Klein, O.
Fröhlich, A.C. Mistry, K.J. Kent, C.F. Martin and J.M. Sands.
Emory Univ.
382
1112.SEX DIFFERENCES IN RENAL FUNCTION AND
DISEASE
Poster
Exhibit Halls A-B
B62
1112.1 Sex
does
not
impact
asymmetric
dimethylarginine or L-arginine levels in spontaneously
hypertensive rats. K.N. Brinson, S. Sharma, M.J. Romero
and J.C. Sullivan. Georgia Hlth. Sci. Univ.
B63
1112.2 Estrogen supplementation increases renal
sodium absorption during high salt consumption in female and
male mice. A. Rouch, L. Kudo, S. Nguyen and M. Nadeem.
Oklahoma State Univ. Ctr. for Hlth. Sci.
B64
1112.3 Postmenopausal response to angiotensin IIinduced hypertension is blunted during perimenopause: a
study in the accelerated ovarian failure model of menopause.
D. Pollow, Jr., J. Perez, A. Booth, E. Constantopoulos, J.P.
Konhilas and H.L. Brooks. Univ. of Arizona.
1113.SEX DIFFERENCES IN BLOOD PRESSURE AND
FLUID VOLUME HOMEOSTASIS
Poster
Exhibit Halls A-B
B65
1113.1 Angiotensin II-pretreated female but not male
rats are protected from pressor response and sympathetic
activation to 2% saline drinking. T. Wei, S.C. Clayton, B. Xue,
M. Hay and A.K. Johnson. Univ. of Iowa and Univ. of Arizona.
B66
1113.2 Sex-specific actions of the prostaglandin E
type 4 receptor to attenuate salt sensitivity and hypertension.
M. Herrera, B. Koller and T.M. Coffman. Duke Univ. and Univ.
of North Carolina at Chapel Hill.
B67
1113.3 Neither hypertension nor sexual maturation
is responsible for elevated mesenteric arterial expression of
TGF-b in female spontaneously hypertensive rats. A.J. Tipton,
M. Womack and J. Sullivan. Georgia Hlth. Sci. Univ.
B68
1113.4 Effects of estrogen on relaxation rates in rat
caudal artery. I. Allawzi, A. Garcia, O. Uzomah and N. Pelaez.
Purdue Univ.
1114.OBESITY AND INFLAMMATION:
CONTRIBUTIONS TO VASCULAR AND RENAL
DISEASE (POSTERS)
Poster
Exhibit Halls A-B
B69
1114.1 Weight-loss surgery rapidly alleviates platelet
hyperactivity in morbid obesity. Y. Dobrydneva, M. Periasamy,
M. Butcher, E. Galkina, N. Kuhn, D. Lieb, M. Fontana, S.
Wohlgemuth and J. Nadler. Eastern Virginia Med. Sch. and
Sentara Med. Gp., Norfolk.
TUESDAYPHYSIOLOGY
B70
1114.2 Role of the angiotensin AT2 receptor in obesitylinked inflammation and renal injury: effect of gender. I. Dhande,
M.A. Khan, S. Nag and T. Hussain. Univ. of Houston.
B71
1114.3 Etanercept improves glucose intolerance and
dyslipidemia in insulin-resistant rats. A. Lee, R. Rodriguez,
R. Ortiz and M. Ryan. Univ. of California Merced and Univ. of
B72
1114.4 Mutation of Sh2b3 attenuates Dahl SS
hypertension via inflammatory signaling. N. Rudemiller, H.
Lund, C. Guo, A. Geurts, H. Jacob and D.L. Mattson. Med.
Col. of Wisconsin.
B73
1114.5 Effect of high-fat diet on resistance artery
function in normal pregnant rats. F.T. Spradley, A.C. Palei and
J.P. Granger. Univ. of Mississippi Med. Ctr.
B74
1114.6 Acute kidney injury following orthopedic trauma
in obese Zucker rats. P. Mittwede, L. Xiang, J. Clemmer, S. Lu,
A. Gowdey and R. Hester. Sch. of Med., Univ. of Mississippi
Med. Ctr.
B75
1114.7 The impact of high mobility group box 1 protein
on renal ischemia-reperfusion injury in male and female
spontaneously hypertensive rats. G.R. Crislip, A.J. Tipton and
J.C. Sullivan. Georgia Hlth. Sci. Univ.
B76
1114.8 Impaired pancreatic function contributes to the
age-dependent development of metabolic syndrome in female
intrauterine growth-restricted rats. S. Intapad, A.D. Brown,
F.L. Tull, J.M. Fahling, J.H. Dasinger, N.B. Ojeda and B.T.
Alexander. Univ. of Mississippi Med. Ctr.
B77
1114.9 Vascular smooth muscle specific deletion of the
leptin receptor attenuates leptin-induced vascular dysfunction.
T.T. Coleman, D.E. Stec and M.J. Ryan. Univ. of Mississippi
Med. Ctr.
1115.WATER AND ELECTROLYTE HOMEOSTASIS:
PATHOPHYSIOLOGY AND PHYSIOLOGY
Poster
Exhibit Halls A-B
B78
1115.1 Renal intramedullary infusion of tempol
normalizes the blood pressure response to intrarenal blockade
of heme oxygenase-1 in angiotensin II-dependent hypertension.
D. Stec and M. Gousset. Univ. of Mississippi Med. Ctr.
B79
1115.2 Indoleamine-2,3-dioxygenase
restrains
hypertension induced by angiotensin II in rats fed a high salt
diet. K. H. Yiew, S.K. Yoon, L. Huang, C. Jin, A.L. Mellor and
D.M. Pollock. Georgia Hlth. Sci. Univ.
B80
1115.3 Increases in renal medullary 20-HETE
formation oppose the development of hypertension and
improves pressure natriuresis in CYP4A1 transgenic Dahl
S rats. S. Murphy, F. Fan, R. Baker and R. Roman. Univ. of
B81
1115.4 Blunting circulating TH17 cells decreases
hypertension and oxidative stress in response to placental
ischemia. D.C. Cornelius, J.P. Hogg, K. Wallace, J. Moseley
and B. LaMarca. Univ. of Mississippi Med. Ctr.
B82
1115.5 Regulation of renal sodium excretion by
medullary NLRP3 inflammasome activation beyond turning on
inflammation. M. Xia, J. Xiong, J.M. Abais, K.M. Boini and
P-L. Li. Virginia Commonwealth Univ.
B83
1115.6 Genetic defects in congenital solitary kidney
rats cause low nephron numbers and predispose to severe
renal damage. X. Wang, A.C. Johnson, J. Lee, L. SolbergWoods and M.R. Garrett. Univ. of Mississippi Med. Ctr. and
Med. Col. of Wisconsin.
B84
1115.7 Hypertension in a rat model of HELLP
syndrome is associated with increased TNF-alpha, IL-6 and
CD4+ T cell activation. K. Wallace, M. Darby, P. Kyle, R. Morris,
J. Moseley, K. Frazier and B. LaMarca. Univ. of Mississippi
Med. Ctr.
B85
1115.8 Sodium storage during high salt intake is not
dependent upon endothelin B receptors. J.S. Speed, J.M. Titze
and D.M. Pollock. Georgia Hlth. Sci. Univ. and Vanderbilt Univ.
B86
1115.9 Hypertonic NaCl intake induces renal TNF
production by a pathway involving NKCC2A and NFAT5. S.
Hao, L. Bellner and N.R. Ferreri. New York Med. Col.
B87
1115.10 Mechanisms of shear stress mediated nitric
oxide production by inner medullary collecting duct cells. K.A.
Hyndman and J.S. Pollock. Georgia Hlth. Sci. Univ.
B88
1115.11 Protein carbonylation regulates renal proximal
tubular Na/K-ATPase signaling and sodium transport. Y. Yan,
Z-j. Xie, J.I. Shapiro and J. Liu. Joan C. Edwards Sch. of Med.,
Marshall Univ., Yanshan Univ., China and Univ. of Toledo.
B89
1115.12 Dynamin 2 is a Ca2+-dependent regulator of
NOS1a and a possible negative regulator of NOS1b. S.K.H.
Morsing, K.A. Hyndman and J.S. Pollock. Georgia Hlth. Sci.
Univ. and Karolinska Inst.
B90
1115.13 Altered thick ascending limb function in aging
female mice consuming high quantities of fructose-sweetened
water. L. Li, A. Yunghans, S-B. Awan, L. Alamri and C.
Ecelbarger. Georgetown Univ.
B91
1115.14 Genotype-phenotype relationship in patients
affected by novel CLCNKB mutations. O. Andrini, M. Keck, A.
Blanchard, R. Vargas-Poussou, S. Lourdel and J. Teulon.
UPMC Univ. and Européen Hosp. Georges Pompidou, Paris.
B92
1115.15 Atractylodes macrocephala regulates water
channel protein expression by hypertonic stress in renal
collecting duct cells. Y.P. Lee, Y.J. Lee, S.M. Lee, J.J. Yoon,
D.H. Kim, B. Li, D.G. Kang and H-S. Lee. Wonkwang Univ.,
South Korea.
B93
1115.16 Effect of Poria cocos on hypertonic stressinduced water channel expression and apoptosis in renal
collecting duct cells. S.M. Lee , Y.J. Lee, J.J. Yoon, B. Li, Y.P.
Lee, D.H. Kim, D.G. Kang and H.S. Lee. Wonkwang Univ.,
South Korea.
B94
1115.17 Peroxisome proliferator activated receptor –
alpha regulation of sodium transport mechanisms in human
primary renal proximal tubule epithelial cells during acute
angiotensin II treatment. K. Doh, T. Hudson and D.L. Lee.
Univ. of Maryland Baltimore County and Howard Univ.
B95
1115.18 The effects of intermittent heat acclimation
on water balance in rats. J. Johnson, A. Beck, E. Ray, V.
Janardan and C. Barney. Hope Col., MI.
B96
1115.19 Biomarkers of kidney disease identified using
a novel rat model and evaluated in human CKD patients. A.C.
Harmon, A.C. Johnson, A. Driesbach and M.R. Garrett.
Univ. of Mississippi Med. Ctr.
B97
1115.20 Glycogen synthase kinase-3 inhibition reduces
renal cystogenesis in polycystic kidney disease. R. Rao, S. Tao,
E. Suderman and P. Pandey. Univ. of Kansas Med. Ctr.
B98
1115.21 A novel treatment for X-linked nephrogenic
diabetes insipidus: the secret in secretin? G. Procino, S.
Milano, M. Carmosino, M.C. Nicoletti, J. Wess and M. Svelto.
Univ. of Bari, Italy and NIDDK, NIH.
383
T
U
E
PHYSIOLOGYTUESDAY
B99
1115.22 What is the physiological relevance of the
renal H,K-ATPase type 2? Example of K+ reabsorption during
K+ depletion, gestation and circadian rhythm. G. Crambert, C.
Lamouroux and A. Salhi. INSERM, Univ Paris 6 - Univ Paris
5, CNRS.
B100 1115.23 Usp2-45 represses aldosterone response by
decreasing mineralocorticoid receptor availability. O. Staub, A.
Debonneville, D. Pouly and N. Faresse. Univ. of Lausanne.
B101 1115.24 Vacuolar proton pump a4 subunit is critical
for inner ear development and renal function. N. Picard, J-C.
Hennings, A. Huebner, T. Stauber, H. Maier, D. Brown, T.
Jentsch, R. Vargas-Poussou, D. Eladari and C. Huebner.
INSERM, Paris, Inst. for Human Genet., Jena, Max Delbrück
Ctr. for Molec. Med., Berlin and Hannover Med. Sch., Germany,
Massachusetts Gen. Hosp. and Hosp. Georges Pompidou,
Paris.
B102 1115.25 Rh proteins mediated ammonia excretion in the
skin of zebrafish larvae: evidence of active ammonia transport
by ionocytes. T-H. Shih, J-L. Horng, Y-T. Lai and L-Y. Lin. Natl.
Taiwan Normal Univ. and Taipei Med. Univ.
B103 1115.26 Enhanced urinary sodium and potassium
excretion in VAMP3 knockout mice. M.Z. Haque and P.A. Ortiz.
Henry Ford Hosp.
1116.NEUROHUMORAL MECHANISMS OF BLOOD
PRESSURE AND VOLUME REGULATION
Poster
Exhibit Halls A-B
B104 1116.1 Is there truly a sympathetic component
to aldosterone hypertension? T. Lohmeier, B. Liu and D.
Georgakopoulos. Univ. of Mississippi Med. Ctr. and CVRx
Inc., Minneapolis.
B105 1116.2 Nicotine reduces blood pressure in mouse
model of systemic lupus erythematosus. K.W. Mathis. Univ. of
B106 1116.3 Nitric oxide impacts on angiotensin AT2
receptors modulation of high-pressure baroreflex control of
renal sympathetic nerve activity in rats. M.H. Abdulla and E.J.
Johns. University Col. Cork, Ireland.
B107 1116.4 Vasopressin infusion increases intravesical
pressure in Wistar rats. E.M. Cafarchio, L.A. Silva, E.
Colombari, C.A. Ogihara, R.L. Almeida and M.A. Sato. Fac.
of Med., ABC, Santo Andre, Brazil and São Paulo State Univ.,
Araraquara.
B108 1116.5 Renal effects produced by microinjection of
kappa opioid agonist into the bed nuclei of the stria terminalis
(BST). C. Franklin, Y. Rangel, L. Fortepiani, G. Toney and H.
Gottlieb. Sch. of Optom., Univ. of Incarnate Word and Univ. of
Texas Hlth. Sci. Ctr. at San Antonio.
LAST DAY TO
VISIT EXHIBITS
Tuesday, April 23
9:00 AM – 4:00 PM
384
1117.ASSESSING POSTGANGLIONIC SYMPATHETIC
NEURONAL DISCHARGE PATTERNS:
IMPLICATIONS FOR UNDERSTANDING
ABERRANT SYMPATHETIC OUTFLOW
(POSTERS)
Poster
Exhibit Halls A-B
B109 1117.1 A case for a standardized method for the
normalization of muscle sympathetic nerve activity amplitude.
D.W. White, V.L. Kay, G. Moralez, W.L. Eubank and P.B.
Raven. Univ. of North Texas Hlth. Sci. Ctr. at Fort Worth.
B110 1117.2 Augmented response of renal sympathetic
nerve single units to chemoreceptor stimuli in rabbits with
angiotensin-induced hypertension. G.A. Head, S.L. Burke
and E.V. Lukoshkova. Baker IDI Heart and Diabetes Inst.,
Melbourne and Natl. Cardiol. Res. Ctr., Moscow.
B111 1117.3 Sympathetic vascular transduction following
spontaneous MSNA bursts is augmented in young black men.
D.P. Credeur, S.W. Holwerda, S.T. Fairfax, D.M. Keller and
P.J. Fadel. Univ. of Missouri-Columbia and Univ. of Texas at
Arlington.
B112 1117.4 Sympathetic and cardiovagal baroreflex
sensitivity in humans: comparison of Valsalva’s maneuver
and spontaneous methodologies. H. Yang and J.R. Carter.
Michigan Technol. Univ.
B113 1117.5 Sympathetic nerve activity and systemic
arterial pressure during obstructive sleep apnea in conscious
rats. C. Sukeguchi and K. Miki. Nara Women’s Univ., Japan.
B114 1117.6 Effect of mental stress on skin sympathetic
nerve activity: are responses reproducible? C.A. Ray, C.L.
Sauder and M.D. Muller. Penn State, Hershey.
B115 1117.7 Evaluation of muscle sympathetic nerve
activity in patients with chronic severe aortic insufficiency.
S.B.P.C. Souza, T.A.D. Accorsi, M. Katz, O.C. Bezerra, G.A.
Neves, M.B.P. Grinberg, F.M. Consolim-Colombo and F.B.P.
Tarasoutchi. Clin Hosp., Sch. of Med., Univ. of São Paulo.
1118.NEURAL CONTROL OF CARDIOVASCULAR
FUNCTION
Poster
Exhibit Halls A-B
B116 1118.1 The effect of gender on sympathetic neural
responses to cold pressor testing in hypertensive seniors. J.M.
Hendrix, T. Bivens, S. Best, Y. Okada, B.D. Levine and Q. Fu.
Univ. of Texas Southwestern Med. Ctr. and Inst. for Exercise
and Envrn. Med., Dallas.
B117 1118.2 Macrophage migration inhibitory factor
decreases neuroinflammation in the solitary tract nucleus
of spontaneously hypertensive rats. A.H. Freiria-Oliveira,
G.T. Blanch, H. Li, D.S.A. Colombari, E. Colombari and C.
Sumners. FOAR-UNESP, Brazil, Univ. of Florida and Southern
Med. Univ., China.
TUESDAYPHYSIOLOGY
B118 1118.3 Elderly blacks have a similar sympathetic
neural responsiveness but greater pressor response to cold
stress than elderly whites. Y. Okada, J. Edwards, S.S. Jarvis,
S.A. Best, R.L. Meier, T.B. Bivens, W. Vongpatanasin, B.D.
Levine and Q. Fu. Texas Hlth. Presbyterian Hosp. Dallas and
Univ. of Texas Southwestern Med. Ctr.
B119 1118.4 P2Y1-receptors are expressed by C1 cells and
regulate peripheral chemoreceptor modulation of breathing and
blood pressure. I.C. Wenker, C.R. Sobrinho, A.C. Takakura,
T.S. Moreira and D.K. Mulkey. Univ. of Connecticut and Univ.
of São Paulo.
B120 1118.5 Activation of NMDA receptors results in
different autonomic and cardiovascular responses along
the rostrocaudal axis of the insular cortex. F.R. Marins, M.
Limborço-Filho, G.C. Vaz, C.H. Xavier and M.A.P. Fontes.
Fed. Univ. of Minas Gerais, Brazil.
B121 1118.6 Distension of central great vein decreases
sympathetic outflow in humans. J. Cui, Z. Gao, C. Blaha, J.
Mast, M.D. Herr and L.I. Sinoway. Penn State Col. of Med.
B122 1118.7 Cardiovascular responses during static skeletal
muscle contraction following neuronal NOS blockade within the
ventrolateral medulla. A. Ally and T.J. Maher. South Col. Sch.
of Pharm., KY and Massachusetts Col. of Pharm. & Hlth. Sci.
B123 1118.8 Respiratory influences on muscle sympathetic
nerve activity and limb vascular conductance in the steadystate. J.K. Limberg, B.J. Morgan, W.G. Schrage and J.A.
Dempsey. Sch. of Educ. and Sch. of Med. and Publ. Hlth., Univ.
of Wisconsin-Madison.
B124 1118.9 The exaggerated exercise pressor reflex in
heart failure: MAPK activation in peripheral dorsal root ganglia.
H. Wang, W. Wang, G.J. Rozanski and I.H. Zucker. Univ. of
Nebraska Med. Ctr.
B125 1118.10 Afferent vagal nerve stimulation resets the
baroreflex neural arc and inhibits sympathetic nerve activity.
K. Saku, K. Sakamoto, K. Hosokawa, T. Kakino, M. Ikeda,
Y. Oga, A. Nishizaki, T. Ide and K. Sunagawa. Kyushu Univ.,
Japan.
B126 1118.11 Hyperadrenergic activity and the postural
tachycardia syndrome. D.A. Low, M.A. Akhtar, V. Iodice, L.
Watson and C.J. Mathias. Imperial Col. London and Natl.
Hosp. for Neurol. and Neurosurg., London.
B127 1118.12 Elevated brain-derived neurotrophic factor
levels in the paraventricular nucleus increase blood pressure,
heart rate and indices of sympathetic activity. B. Erdos, I.
Backes, M.L. McCowen and D.A. Scheuer. Univ. of Florida.
B128 1118.13 Severe
hemorrhage
attenuates
cardiopulmonary chemoreflex control of renal and adrenal
sympathetic nerves via adenosine operating in the nucleus of
the solitary tract. Z. Minic, C. Li, D.S. O’Leary and T.J. Scislo.
Wayne State Univ. Sch. of Med.
B129 1118.14 Sympathoinhibition in men during paced
breathing at 0.25 Hz. N. Coverdale, C.W. Usselman, T.I.
Gimon, C.A. Nielsen, T.A. Luchyshyn and J.K. Shoemaker.
Western Univ., Canada.
B130 1118.15 Immunohistochemistry confirms the functional
evidence that the cardiopulmonary chemoreflex pathways in
the caudal nucleus of the solitary tract are directly inhibited by
A1 adenosine receptors and indirectly inhibited by A2a receptor
Z. Minic, D.S. O’Leary, H.G. Goshgarian and T.J. Scislo.
B131 1118.16 Muscle metaboreflex-induced increases in
ventricular performance are limited in hypertension due to
exaggerated coronary vasoconstriction. M.D. Spranger, J.A.
Sala-Mercado, J. Kaur, R. Abu-Hamdah and D.S. O’Leary.
B132 1118.17 Lack of interaction of co-existing TRPV1 and
CB1 receptors indicates differential control of separate basal
and synchronous glutamate release mechanisms in the
solitary tract nucleus. M.C. Andresen, M.E. Hofmann and J.A.
Fawley. Oregon Hlth. & Sci. Univ.
B133 1118.18 Individual differences in cardiac and vascular
components of the pressor responses to isometric handgrip
exercise in humans. K. Watanabe, M. Ichinose, R. Tahara and
T. Nishiyasu. Univ. of Tsukuba and Meiji Univ., Japan.
B134 1118.19 Hormone-phase dependence of muscle
sympathetic nerve activity in young healthy women using
hormonal contraceptives. C.W. Usselman, T.A. Luchyshyn, T.I.
Gimon, C.A. Nielson, S.H.M. Van Uum and J.K. Shoemaker.
Sch. of Kinesiol. and Schulich Sch. of Med. and Dent., Western
Univ., Canada.
B135 1118.20 Rheumatoid arthritis and arterial baroreflex
function. A.M. Adlan, G. Kitas, J.F.R. Paton, G.Y.H. Lip and
J.P. Fisher. Univ. of Birmingham, Russells Hall Hosp., Dudley,
Univ. of Bristol and City Hosp., Birmingham, U.K.
B136 1118.21 Diminished baroreflex function following
ovariectomy is a consequence of the reduced excitability
of a sex-specific population of low threshold myelinated
baroreceptor afferents in the rat. G.C. Santa Cruz Chavez, B.
Li and J.H. Schild. Indiana Univ.-Purdue Univ. Indianapolis.
B137 1118.22 Auditory and visual stimuli evoke a
synchronized activation of sympathetic, respiratory and motor
outputs after disinhibition of midbrain colliculi. F.C.F. MullerRibeiro, M.P. Fontes, R.A.L. Dampney and A.K. Goodchild.
Macquarie Univ., Australia, Fed. Univ. of Minas Gerais, Brazil
and Sydney Univ.
B138 1118.23 Influence of age on respiratory modulation
of muscle sympathetic nerve activity and blood pressure
in humans. A. Shantsila, D.B. McIntyre, G.Y.H. Lip, J.F.R.
Paton, P.J. Fadel, A.E. Pickering and J.P. Fisher. Univ.
of Birmingham and City Hosp., U.K., Univ. of Bristol Sch. of
Physiol. & Pharmacol. and Univ. of Missouri-Columbia.
B139 1118.24 Gene expression of NMDA receptor subunits
using laser capture microdissection in the rostral ventrolateral
medulla of sedentary versus physically active rats. M.
Subramanian, A.G. Holt and P.J. Mueller. Wayne State Univ.
B140 1118.25 Immunofluorescence identifies the a1 subunit
of the GABA A receptor on spinally projecting neurons in rostral
ventrolateral medulla. M.D. Dombrowski, I.J. Llewellyn-Smith
and P.J. Mueller. Wayne State Univ. Sch. of Med. and Flinders
Med. Ctr., Australia.
B141 1118.26 Water drinking enhances the gain of arterial
baroreflex control of muscle sympathetic nerve activity in
healthy humans. L.C. Vianna, I.A. Fernandes, D.G. Martinez,
B.M. Silva, P.J. Fadel and A.C. Nobrega. Fluminense Fed.
Univ. and Salgado Oliveira Univ., Brazil and Univ. of MissouriColumbia.
B142 1118.27 Heart rate variability and cardiorespiratory
fitness in African American men. R.L. Herron and M.R. Esco.
Univ. of Alabama and Auburn Univ. Montgomery.
B143 1118.28 Neurocardiovascular effects of V1b receptor
blockade within paraventricular nucleus in conscious Sprague
Dawley rats. W.M. El Werfali, M. Maliszewska-Scislo, H.
Chen and N.F. Rossi. Wayne State Univ. and John D. Dingell
VA Med. Ctr.
B144 1118.29 Sympatho-inhibition in an ovine model of septic
shock: cardiovascular and renal effects. C. May, R. Bellomo
and P. Calzavacca. Florey Inst. of Neurosci. and Ment. Hlth.
and Austin Hlth., Melbourne.
385
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PHYSIOLOGYTUESDAY
B145 1118.30 Increasing leptin sensitivity via PTP1B deletion
does not increase blood pressure through an increased
sympathetic tone in mice on a Balb/c background. B.R. Butler,
J.B. Norman, M.L. Tremblay and E.J. Belin de Chantemele.
Georgia Hlth. Sci. Univ. and McGill Univ.
B146 1118.31 Continuous
and
intermittent
electrical
stimulation of the aortic depressor nerve in conscious rats:
time course of the hemodynamic responses. H. Salgado, F.
Brognara, D.P.M. Dias, J.A. Castania and R. Fazan, Jr. Univ.
of São Paulo, Ribeirão Preto.
B147 1118.32 Technique-dependent considerations when
assessing racial differences in arterial baroreflex function. D.M.
Keller, S.W. Holwerda, D.P. Credeur and P.J. Fadel. Univ. of
Texas at Arlington and Univ. of Missouri-Columbia.
B148 1118.33 Carotid baroreflex control of heart rate is
enhanced during whole-body heat stress. D. Krnjajic, C.L.
Butts, W.S. Warren, M.R. Samels and D.M. Keller. Univ. of
Texas at Arlington.
B149 1118.34 Arterial baroreflex control of sympathetic
nerve activity during acute hypotension is enhanced in young
normotensive black men. S.W. Holwerda, D.M. Keller, D.P.
Credeur and P.J. Fadel. Univ. of Missouri-Columbia and Univ.
of Texas at Arlington.
B150 1118.35 Astrocytes influence SON and PVN
neurosecretory and presympathetic neuronal excitability
via activation of an extrasynaptic NMDA/A-type K+ channel
coupling mechanism. K. Naskar and J.E. Stern. Georgia Hlth.
Sci. Univ.
B151 1118.36 A novel relationship between estrogen, insulin
resistance, and cardiovagal baroreflex sensitivity in obese
PCOS women. J.A. Miner, J.C. Miner, V.E. Brunt, P.F. Kaplan
and C.T. Minson. Univ. of Oregon and Oregon Hlth. & Sci. Univ.
B152 1118.37 An inverse relationship between testosterone
and muscle sympathetic nerve activity: an investigation in lean
healthy females. E.E. Madison, J.C. Miner, J.A. Miner, P.F.
Kaplan and C.T. Minson. Univ. of Oregon and Oregon Hlth. &
Sci. Univ.
B153 1118.38 The neurosteroid metabolite of progesterone,
3a-OH-dihydroprogesterone, is required for attenuated
baroreflex mediated sympathoexcitation in pregnancy. J.G.
Phaup, E.M. Hasser and C.M. Heesch. Univ. of MissouriColumbia.
B154 1118.39 Testosterone increases muscle sympathetic
nerve activity in young healthy males. J.C. Miner, J.A. Miner,
P.F. Kaplan and C.T. Minson. Univ. of Oregon and Oregon
Hlth. & Sci. Univ.
B155 1118.40 Autonomic reflexes may contribute to the
symptomatology of mal de debarquement syndrome. T.E.
Wilson, A.D. LePorte, K. Toma, J.S. Thomas and B.C. Clark.
Ohio Univ. Heritage Col. of Osteo. Med.
B156 1118.41 Mindfulness meditation lowers blood pressure
and sympathetic activity in hypertensive patients with chronic
kidney disease. J. Park and S. Bauer-Wu. Emory Univ. Sch. of
Med. and Sch. of Nursing.
386
1119.NEURAL CONTROL OF CARDIOVASCULAR
FUNCTION: THE VASCULATURE
Poster
Exhibit Halls A-B
B157 1119.1 Impaired hypoxic vasodilation in healthy older
adults: role for altered sympatho-adrenal control of vascular
tone. J.C. Richards, A.R. Crecelius, B.S. Kirby, L.J. Garcia,
G.J. Luckasen, D.G. Larson and F.A. Dinenno. Colorado
State Univ. and Med. Ctr. of Rockies, Loveland, CO.
B158 1119.2 The role of a-adrenergic receptors in mediating
beat-by-beat sympathetic vascular transduction in resting
humans. S.T. Fairfax, D.P. Credeur, S.W. Holwerda, M.Y.
Zuidema, J.H. Medley, P.C. Dyke II and D.W. Wray. Univ. of
Missouri-Columbia and Univ. of Utah.
B159 1119.3 Alternative pathway to angiotensin converting
enzyme for angiotensin II generation in mouse mesenteric
artery. C. Becari, M.A. Barbosa da Silva, H.C. Salgado,
R.C.A. Tostes, E.B. Oliveira and M.C.O. Salgado. Fac. of
Med. of Ribeirão Preto, Univ. of São Paulo.
B160 1119.4 Effects of the reversible acetylcholinesterase
inhibitor pyridostigmine on vascular reactivity of spontaneously
hypertensive rats. R.M. Lataro, M.A.B. Silva, R.C.A. Tostes
and H.C. Salgado. Sch. of Med. of Ribeirão Preto, Univ. of São
Paulo.
B161 1119.5 The 5-HT1A receptor and sympathetic
neurotransmission to mesenteric blood vessels in salt-sensitive
hypertension. J.D. Bomar and J.J. Galligan. Michigan State
Univ.
1120.NEURAL CONTROL OF VISCERAL AND
METABOLIC FUNCTION
Poster
Exhibit Halls A-B
B162 1120.1 Further studies on the sensory motor
integration of gill lateral cilia in the bivalve mollusc Crassostrea
virginica. P. Williams, P. Akande, E.J. Catapane and M.A.
Carroll. Medgar Evers Col., CUNY.
B163 1120.2 Glycemic control by the brain renin-angiotensin
system: role for peripheral AT2 receptors. B.J. Weidemann,
N.K. Littlejohn, C.D. Sigmund and J.L. Grobe. Univ. of Iowa.
B164 1120.3 Shp2 signaling in Pomc neurons is important
for leptin’s actions on blood pressure, energy balance and
glucose homeostasis. J.M. do Carmo, A.A. da Silva, P.O.
Sessums, S.H. Ebaad and J.E. Hall. Univ. of Mississippi Med.
Ctr.
B165 1120.4 Glucoprivation of hypothalamic neurons elicits
the counter-regulatory response in rats. T.J. Verberne and
W.S. Korim. Univ. of Melbourne.
B166 1120.5 Systemic CCK increases brown adipose tissue
sympathetic nerve activity. C.J. Madden. Oregon Hlth. & Sci.
Univ.
TUESDAYPHYSIOLOGY
1121.BLOOD BRAIN BARRIER, BLOOD FLOW AND
METABOLISM
1123.CENTRAL REGULATION OF FOOD INTAKE AND
BODY WEIGHT
Poster
Poster
Exhibit Halls A-B
Exhibit Halls A-B
B167 1121.1 In vitro modeling of inflammation-induced
blood-brain barrier dysfunction in sickle cell disease. H.
Parfenova, T. Pestina, D. Persons and S. Basuroy. Univ. of
Tennessee, Memphis and St. Jude Children’s Res. Hosp.
B168 1121.2 Role of NOS in early-stage BBB disruption
following transient focal cerebral ischemia. Z. Jiang, C. Li, D.M.
Arrick, S. Yang and H. Sun. LSU Hlth. Sci. Ctr.-Shreveport.
B169 1121.3 Cerebrovascular reactivity and implications
for understanding the pathophysiology of multiple sclerosis.
O. Pucci, A. Battisti-Charbonney, J. Fierstra, D.M. Mandell,
D. Mikulis, J. Poublanc, A. Crawley, J. Fisher and J. Duffin.
Univ. of Toronto and Univ. Hlth. Network, Toronto.
B170 1121.4 Cerebrovascular reactivity to carbon dioxide: a
theoretical examination. O. Pucci, A. Battisti-Charbonney, J.
Fierstra, J. Poublanc, A. Crawley, D.M. Mandell, D. Mikulis, J.
Fisher and J. Duffin. Univ. of Toronto and Univ. Hlth. Network,
Toronto.
B171 1121.5 Role of fibrinogen in traumatic brain injury. N.
Muradashvili, R. Tyagi, R.L. Benton and D. Lominadze. Univ.
of Louisville.
B172 1121.6 Choroid plexus inorganic phosphate (Pi)
transport: stress-induced alteration of PiT-1 (Slc20A1)
localization. J.L. Renfro, S.L. Parker and A. Bataille. Univ. of
Connecticut.
B173 1121.7 Aerobic training improves the integrity blood
brain barrier in spontaneously hypertensive rats. L. Buttler,
M.T. Jordão and L.C. Michelini. Univ. of São Paulo.
B174 1121.8 Low-dose cadmium exposure upregulates
glutathione (GSH) synthesis in cultured choroid plexus. A.
Villalobos, R. Young and S. Francis Stuart. Texas A&M Univ.
1122.BRAIN DEVELOPMENT AND AGING
Poster
Exhibit Halls A-B
B175 1122.1 Lactational DEHP exposure-impaired motor
coordination and motor skill learning in adolescent rats. S-C.
Yueh, R-C. Yang and D-C. Wang. Kaohsiung Med. Univ.,
Taiwan.
B176 1122.2 Microglia display distinct sex-dependent
gene expression profiles in the postnatal and adult CNS. M.
Nikodemova, J. Crain and J.J. Watters. Univ. of WisconsinMadison.
B177 1123.1 Control of feeding behavior by CRH 2
receptors in the paraventricular nucleus of the hypothalamus of
adrenalectomized rats. M. Rito-Domingo, V.E. López Alonso,
K.A. Reyes Santos, G. Ambrocio Segundo, K. Cruz García
and J.M. Mancilla Díaz. Natl. Autonomous Univ. of Mexico.
B178 1123.2 Nesfatin-1 does not influence intracellular
calcium concentrations in neurons of the nucleus of the
solitary tract or the paraventricular nucleus. A. Mimee and A.V.
Ferguson. Queen’s Univ., Canada.
B179 1123.3 Nesfatin-1 influences the excitability of
subfornical organ neurons. M.A. Kuksis, L. Dai and A.V.
Ferguson. Queen’s Univ., Canada.
B180 1123.4 Intrauterine undernutrition programs the
hypothalamic proteome of female rats. E.B. Ribeiro, A.P.
Pedroso, A.P. Souza, A.P.S. Dornellas, D. Estadella, C.M.O.
Nascimento, L.M. Oyama, J.C. Rosa and R.L.H. Watanabe.
Fed. Univ. of São Paulo.
B181 1123.5 Subfornical organ: a novel site for the actions
of cholecystokinin. A-S.F. Ahmed, A.V. Ferguson and K.A.
Sharkey. Univ. of Calgary and Queen’s Univ., Canada.
B182 1123.6 A monoclonal antibody targetting the FGFR1c isoform reduces body weight and food intake, which
is, associated with a suppression of deiodinase 2 mRNA
expression in hypothalamic tanycytes. R. Samms, A. Lory, J.
Roberts, A. Warner, S. Sundquis, P. Emmerson, B. Perry, K.
Tsintzas and F. Ebling. Univ. of Nottingham, Karolinska Inst.,
Eli Lilly and Univ. of Aberdeen.
B183 1123.7 Photic stimulation is required to elicit estrogeninduced anorexia in rats. K. Mabuchi, A. Takano, Y. Hara, K.
Morimoto and A. Takamata. Nara Women’s Univ, Japan.
B184 1123.8 Insulin and glucose stimulation of vasopressin
and oxytocin release requires glucokinase and PI3 kinase. C.D.
Sladek, Z. Song and W. Stevens. Univ. of Colorado Sch. of
Med.
B185 1123.9 Taste without calories is insufficient to drive
conditioned flavor preferences. J.M. Stratford and T.E. Finger.
Univ. Colorado Denver Anschutz Med. Campus.
B186 1123.10 Orchiectomy increases food intake and
perifornical orexin A neuron’s activity during glucoprivation. A.
Takamata, K. Miyake, K. Mabuchi and K. Morimoto. Nara
Women’s Univ, Japan.
B187 1123.11 Insulin-induced increase in intracellular
calcium in the supraoptic nucleus neurons requires activation
of PI3 kinase. Z. Song, W. Stevens and C.D. Sladek. Univ. of
Colorado Sch. of Med.
B188 1123.12 Hypophysectomy attenuates leptin-induced
tachycardia without affecting leptin’s action on appetite and
body weight. A.A. da Silva, Z. Wang, J.E. Hall and J.M. do
Carmo. Univ. of Mississippi Med. Ctr.
B189 1123.13 Adiponectin
receptor
mediated
weight
regulation: an inflammation-independent mechanism? Z.A.P.
Wintrob, H. Radpasand, M.H. Elmeshad, A. Barima, J.L.
Rabey, K.A. Chmiel, Z.S. Fayazi, L. Otvos, E. Surmacz, S.
Faitar and A.C. Ceacareanu. Univ. at Buffalo, D’Youville Col.,
NY and Temple Univ. and Sbarro Inst. for Cancer Res.
387
T
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PHYSIOLOGYTUESDAY
1124.COGNITION AND BEHAVIOR
Poster
Poster
Exhibit Halls A-B
Exhibit Halls A-B
B190 1124.1 Correlation and causation: systems level
understanding of decision-making signals at the single-neuronal
level in the human brain. S.R. Patel, S. Sheth, M. Mian, S.
Bourne, A. Flaherty and E. Eskandar. Massachusetts Gen.
Hosp.
B191 1124.2 Avoidance of environmental gas irritants
mediated by TRPA1. T. Yonemitsu, N. Takahashi, Y. Mori,
Y. Kanmura and T. Kuwaki. Grad. Sch. of Med. Dent. Sci.
Kagoshima Univ. and Grad. Sch. of Engin., Kyoto Univ.
B192 1124.3 Less exercise, more effects: enhancement
of cognitive functions associated with hippocampal BDNF
signaling by voluntary resistance wheel running in adult rats.
M.C. Lee, Y.F. Liu, K. Inoue, M. Okamoto and H. Soya. Inst.
for Hlth. and Sports Sci., Tsukuba, Japan.
B193 1124.4 Omega-3 fatty acid supplementation improves
adaptive coping in a rat model of post-partum depression. E.M.
Gonzales, D.W. Barrett, F. Gonzalez-Lima and M.A. Lane.
Texas State Univ., San Marcos and Univ. of Texas at Austin.
B194 1124.5 Stress and immune function of social drinking
college students before and after spring break. S. Sharma, K.
Howard, R. Graham and N. Ceballos. Texas State Univ.-San
Marcos.
B195 1124.6 Decreased neurogenesis in the dentate gyrus
following sensory non-normative overstimulation. J.S.B.
Ramirez, D.A. Christakis, R.D. Hodge, R.F. Hevner, A.F.
Smith, T.K-M. Ramirez, M.F. Burgos and J.M. Ramirez.
Seattle Children’s Res. Inst., Univ. of Washington and Univ. of
Chicago.
B196 1124.7 Behavioral profile assessment in offspring
of Swiss mice underwent to neonatal treatment with
D-fenfluramine. R.L. Melo, A.L.B. Silveira, F.A.C. Seara, F.F.
Rocha, L.C. Reis and W.S. Cortes. Fed. Rural Univ. of Rio de
Janeiro, Seropédica.
B197 1124.8 Behavioral profile assessment in offspring of
Swiss mice treated during pregnancy and lactation with caffeine.
A.L.B. Silveira, R.L. Melo, F.A.C. Seara, C.S. Almeida, F.F.
Rocha, A.S.N. Santos, B.G. Marinho, L.C. Reis and W.S.
Cortes. Fed. Rural Univ. of Rio de Janeiro, Seropédica.
B198 1124.9 Perinatal exposure to low levels of carbon
monoxide impairs neurobehavior in adult mice. J.T. O’Neill,
M.L. Kehl, K.P. Johnson, K. Cravedi, E.S. Barry and N.E.
Grunberg. Uniformed Svcs. Univ. of Hlth. Sci.
B199 1124.10 Comparison of floor aerobics and treadmill
walking on cognitive changes and participant satisfaction. J.
Larsen, C-L. Hansen, M. Schmitter-Edgecombe and J.
Knuth. Washington State Univ.
388
1125.PERIPHERAL CIRCULATION
B200 1125.1 Heterogeneous
vasodilator
pathways
underlying flow mediated dilation are preserved in healthy
aging. K.D. Ballard, M.E. Tschakovsky, A.L. Zaleski, D.M.
Polk, P.D. Thompson, F.J. Kiernan and B.A. Parker. Hartford
Hosp., CT, Sch. of Kinesiol. and Hlth. Studies, Queen’s Univ.,
Canada and Univ. of Hartford.
B201 1125.2 High dietary sodium reduces flow mediated
dilation similarly in humans with salt sensitive and salt resistant
blood pressure. E.L. Matthews, J.J. DuPont, J.L. Greaney,
S.L. Lennon-Edwards, D.G. Edwards and W.B. Farquhar.
Univ. of Delaware.
B202 1125.3 Role of forearm vasoconstriction in the
development of primary Raynaud’s disease. Z. Hussain, G.
Ball and J.E. Davis. Alma Col., MI.
B203 1125.4 Sensitivity of forearm critical power to acute
manipulation of perfusion pressure. J. M. Kellawan, R.F.
Bentley, J.J. Walsh, J.S. Moynes and M.E. Tschakovsky.
Sch. of Kinesiol and Hlth. Studies, Queen’s Univ., Canada.
B204 1125.5 Contributions of cyclooxygenase and NO
synthase pathways to endothelium-dependent dilatation in the
finger of women. J.M. Marshall. Univ. of Birmingham, U.K.
B205 1125.6 Individual vasodilatory response heterogeneity
during progressive forearm exercise: evidence for vasodilator
phenotypes. R.F. Bentley, J.M. Kellawan, J.S. Moynes, V.J.
Poitras, J.J. Walsh and M.E. Tschakovsky. Sch. of Kinesiol.
and Hlth. Studies, Queen’s Univ., Canada.
B206 1125.7 Pro-atherogenic blood flow and shear patterns
acutely induce the release of CD62E+ and CD31+/CD42bendothelial microparticles in humans. N.T. Jenkins, J. Padilla,
L. Boyle, D.P. Credeur, M.H. Laughlin and P.J. Fadel. Univ. of
Missouri-Columbia.
B207 1125.8 Carotid artery intima-media echogenicity and
aortic stiffness in healthy middle-aged and older humans.
K. Aizawa, S. Elyas, D.D. Adingupu, F. Casanova, K.M.
Gooding, D.M. Mawson, A.C. Shore, W.D. Strain and P.E.
Gates. Univ. of Exeter Med. Sch., U.K.
B208 1125.9 Lower potassium intake is associated with
increased wave reflection in young healthy males. S. LennonEdwards, T. Schellhardt, B. Allman, W.B. Farquhar and D.G.
Edwards. Univ. of Delaware.
B209 1125.10 Mitochondria-targeted antioxidant therapy
with MitoQ ameliorates age-related vascular endothelial
dysfunction. R.A. Gioscia-Ryan, T.J. LaRocca, M.C. Zigler,
M.P. Murphy and D.R. Seals. Univ. of Colorado Boulder and
Univ. of Cambridge.
B210 1125.11 Model predictions of arterial adaptation to
steady-flow left ventricular assist devices. P.H. Nguyen, E.
Tuzun, S.F. Knezek, M.W. Mohiuddin and C.M. Quick.
Michael E. DeBakey Inst. and Texas A&M Inst. for Preclin.
Studies.
TUESDAYPHYSIOLOGY
1126.CARDIAC FUNCTION AND DYNAMICS I
1127.ENDOTHELIAL CELL BIOLOGY III
Poster
Poster
Exhibit Halls A-B
Exhibit Halls A-B
B211 1126.1 Is myocardial iron content associated
with left atrial systolic function in asymptomatic hereditary
hemochromatosis? Y. Shizukuda, D. Tripodi, V. Sachdev, C.
Brenneman, S. Sidenko, M. St. Peter, C. Bolan, Y.Y. Yau, A.
Arai, P. Bandettini, S. Leitman and D. Rosing. NHLBI, NIH,
Univ. of Cincinnati and NIH Clin. Ctr.
B212 1126.2 Epicardial force and strain measurements from
the in vivo murine heart. C. Constantinides, M. Michaelides
and S. Georgiadou. Univ. of Cyprus, Cyprus and Natl.
Reference Lab. for Animal Hlth., Cyprus.
B213 1126.3 Longitudinal assessment of systolic and
diastolic function using conventional and speckle tracking
echocardiography following acute ischemia and prolonged
reperfusion in the rat. W. Bao, F. Wright, Z. Ao, R.C. Mirabile,
K.S. Frazier, R.W. Coatney, C.G. Schnackenberg and B.M.
Jucker. GlaxoSmithKline.
B214 1126.4 Measurement of heart function for myocardial
infarction model of rat by microCT. S. Matsushita, M. Naito
and A. Amano. Juntendo Univ., Japan.
B215 1126.5 Cardiovascular response to an inhaled
b-agonist in patients with heart failure: effect of b-blockade.
M. Martinez, S.E. Baker, B. Taylor, B.D. Johnson and E.M.
Snyder. Univ. of Arizona, Mayo Clin. and Univ. of Minnesota,
Minneapolis.
B216 1126.6 Interaction of mitofilin with respiratory
complexes in mitochondrial subpopulations. D. Thapa, R.
Jagannathan, T.L. Croston, W.A. Baseler, C.E. Nichols, D.L.
Shepherd, S.E. Lewis and J.M. Hollander. West Virginia Univ.
B217 1126.7 Age dependency of autonomic response to
recumbent positions. R. Sato, K. Sasaki, M. Haga, H. Sato, Y.
Kimura, E. Kanno and R. Maruyama. Tohoku Univ. Grad. Sch.
of Med., Japan and Univ. of Tokyo Hosp.
B218 1126.8 A rat model of doxorubicin-induced late-onset
cardiotoxicity. N.M. Gibson, C-Y. Lien, B.T. Jensen, D.S.
Hydock and R. Hayward. Univ. of Northern Colorado, Taiwan
Natl. Univ. and Slippery Rock Univ.
B219 1126.9 Endovascular dual-sensor composite sensor
catheter for the measurement of flow and pressure in rats using
telemetry. K. Pitsillides, M. Lin, L. Griffiths, D. Uyeminami, K.
Johnson and K. Pinkerton. Transonic EndoGear Inc., Davis
and Univ. of California, Davis.
B220 1126.10 Oxidative stress level mediates the inotropic
effects of alcohol on the heart. M. AlRubaiee, N. Umoh, M.
Jeffress, R. Walker, V. Cousins and G.E. Haddad. Howard
Univ.
B221 1126.11 Ursolic acid potentiates muscarinic receptorinduced ANP secretion in perfused beating rat atria. H.Y. Kim,
O.J. Kwon, J.H. Kho, R. Tan, K.W. Cho, D.G. Kang and H.S.
Lee. Wonkwang Univ., South Korea.
B222 1127.1 Protease-activated
receptor-3
signals
independent of protease-activated receptor-1 to regulate
endothelial nitric oxide synthase in human endothelial cells.
L.C. Tillery and E. Motley-Johnson. Meharry Med. Col.
B223 1127.2 Sex differences in aortic endothelial function
of streptozotocin-induced diabetic rats: a possible role of
superoxide production. X. Han, R. Zhang, L. Anderson and R.
Rahimian. Univ. of Pacific.
B224 1127.3 L-leucine inhibits nitric oxide synthesis in
endothelial cells. Y. Yang, C. Meininger, K. Kelly, Z. Wu, F.
Bazer and G. Wu. Texas A&M Univ.
B225 1127.4 Physiologic cyclic strain stimulates heme
oxygenase-1 gene expression in endothelial cells: role in cell
survival and proliferation. W. Durante, X-m. Liu and K.J.
Peyton. Univ. of Missouri-Columbia.
B226 1127.5 b-Arrestin-mediated
signal
transduction
participates in laminar shear stress-induced production of nitric
oxide in endothelial cells. A.P.C. dos Santos, V.G. Barauna,
M.H.F. Alaniz, A.C.C. Girardi and J.E. Krieger. Univ. of São
Paulo Med. Sch.
B227 1127.6 Endothelial cells from different vascular bed
respond to secondhand smoke differently under dynamic shear
stress. W. Yin, E.C. Ngwe and D.A. Rubenstein. Oklahoma
State Univ.
B228 1127.7 Disturbed flow increases caveolae-mediated
oxLDL uptake in endothelial cells. E. LeMaster, S. Sun, V.
Shinin, D. Eddington, M. Cho, R. Minshall and I. Levitan.
Univ. of Illinois at Chicago.
B229 1127.8 20-HETE activates endothelial ACE via an IKK/
NF-kB dependent pathway. V.G. Garcia, L. Milhau, J.R. Falck
and M.L. Schwartzman. New York Med. Col., Fac. of Pharm.,
Montpellier, France and Univ. of Texas Southwestern Med. Ctr.
B230 1127.9 Tachycardia promotes mitochondrial DNA
damage by JNK translocation to mitochondria. N. Jen, R. Li
and T. Hsiai. Univ. of Southern California.
T
U
E
1128.INFLAMMATION AS AN ORCHESTRATOR IN
HEART FAILURE (POSTERS)
Poster
Exhibit Halls A-B
B231 1128.1 The role of TNF-a in cardioprotection induced
by adaptation to chronic hypoxia in rats. J. Neckar, A. Chytilova,
G.H. Borchert and F. Kolar. Inst. of Physiol. Acad. of Sci. of
Czech Republic, Prague.
B232 1128.2 Thromboxane A2 mediates apoptosis in
cardiomyocytes via IP3. C.D. Touchberry, C.J. Elmore, S.
Srinivas and M.J. Wacker. Sch. of Med., Univ. of MissouriKansas City.
B233 1128.3 Gene expression profiling in the rat infarcted
heart in response to antioxidant treatment. W. Zhao, T. Zhao,
Y. Chen, Y. Qu, I.C. Gerling, K.T. Weber and Y. Sun. Univ. of
Tennessee, Memphis.
389
PHYSIOLOGYTUESDAY
B234 1128.4 The protection of urocortin 2 against ischemia/
reperfusion injury is due to p38 MAPK downregulation in an
isolated rat heart model. Y. Zhou, X. Gao, D. Wang, K. Lew,
A. Richards and P. Wang. Natl. Univ. of Singapore, Huashan
Hosp., Shanghai and Putuo Hosp., Shanghai.
B235 1128.5 Crosstalk between Toll-like receptor 4 and
interleukin 10 in cardiomyocyte survival. A.K. Bagchi, A.
Sharma, G. Akolkar and P.K. Singal. St. Boniface Res. Ctr.,
Univ. of Manitoba.
B236 1128.6 CD40-CD40
ligand
(CD40L)
signaling
modulates cardiac hypertrophy in angiotensin-IIi induced
hypertensive heart disease. W. Derks, E. Lutgens, M. van
Bilsen and S. Heymans. Maastricht Univ. and Acad. Med. Ctr.,
Amsterdam.
B237 1128.7 Thromboxane A2 mimetic, U46619, does not
induce markers of pathological hypertrophy in cardiomyocytes.
M.J. Wacker, V. Tchikrizov, H.K. Swan, L.A. Wetmore and
C.D. Touchberry. Sch. of Med., Univ. of Missouri-Kansas City
and William Jewell Col., MO.
B238 1128.8 Osteonectin protects against adverse cardiac
inflammation during viral myocarditis. A. Papageorgiou,
M. Rienks, D. Vanhoutte, W. Verhesen, P. Carai, T.
Vandendriessche, M. Chuah and S. Heymans. Maastricht
Univ., Netherlands, Univ. Leuven, Belgium and Cincinnati
Children’s Hosp. Med. Ctr.
B239 1128.9 The role of inflammatory responses in alcoholic
cardiomyopathy. R.K. Walker and G.E. Haddad. Howard Univ.
B240 1128.10 Cannabinoid 1 receptor promotes cardiac
dysfunction, oxidative stress, inflammation, and fibrosis in
diabetic cardiomyopathy. P. Pacher, M. Rajesh, S. Batkai, P.
Mukhopadhyay, W-S. Lee, B. Horvath, R. Cinar, L. Liaudet,
K. Mackie and G. Haskó. NIAAA, NIH, Rockville, Univ. Hosp.,
Lausanne, Indiana Univ. and UMDNJ-New Jersey Med. Sch.,
Newark.
B241 1128.11 Circulating inflammatory mediators as potential
biomarkers for heart failure: a study of the baseline levels in
healthy volunteers. R. Altara, M.H.M. Hessel, M. Manca, H.P.
Brunner-La Rocca, A.P.M. Gorgels, R.J.J. Hermans, B.J.A.
Janssen, H.A.J. Struijker Boudier and M.W. Blankesteijn.
Maastricht Univ., Netherlands.
B242 1128.12 Prohibitin coordinates an anti-inflammatory/
antioxidant feedback loop from mitochondria to nucleus to
protect the heart from severe inflammatory stress. T.A. Mattox,
K.A. Thayne and E.J. Anderson. Brody Sch. of Med. at East
Carolina Univ.
B243 1128.13 Differential response of cardiac NOX-2 and -4
to mild and severe pressure overload. J.M. Bradley, M.C. El
Hajj, A.J. Mouton, E.C. El Hajj and J.D. Gardner. LSU Hlth.
B244 1128.14 Circulating
Porphyromonas
gingivalis
lipopolysaccharide induces left ventricular dysfunction through
MMP-9 regulation of inflammation. K.Y. DeLeon, L.E. de
Castro Bras, J. Zhang and M.L. Lindsey. Univ. of Texas Hlth.
Sci. Ctr. at San Antonio.
B245 1128.15 Lysyl oxidase inhibition in the volume overloaded
heart prevents adverse collagen remodeling, apoptosis, and
cardiac dysfunction. M.C. El Hajj, T.G. Voloshenyuk, M.A.
Claudino, J.M. Bradley and J.D. Gardner. LSU Hlth. Sci. Ctr.,
New Orleans.
B246 1128.16 The inflammatory mediator SH2B3 increases
risk of heart failure. M.J. Flister, C. Moreno, M.J. Hoffman,
S.Z. Prisco, J. Lazar, J.L. Hall and H.J. Jacob. Med. Col. of
Wisconsin and Univ. of Minnesota, Minneapolis.
390
B247 1128.17 Nicotine reduced post-infarct inflammation and
improved cardiac output during exercise in conscious mice.
H.L. Lujan, R. Wang, A.J. Blumberg and S.E. DiCarlo. Wayne
State Univ. Sch. of Med.
B248 1128.18 Epidermal growth factor receptor-tyrosine
kinase inhibition by erlotinib causes hypomagnesemia,
oxidative stress and cardiac dysfunction. W.B. Weglicki, I.T.
Mak, J.J. Chmielinska, C.F. Spurney and J.H. Kramer. The
George Washington Univ. and Children’s Natl. Med. Ctr.
1129.MATRIX METALLOPROTEINASES IN THE
CARDIOVASCULAR SYSTEM (POSTERS)
Poster
Exhibit Halls A-B
B249 1129.1 S100A4 is a key regulator of matrix
metalloproteinases expression in vascular smooth muscle
cells. V. Lemaitre, J-A. Weir and H. Miura. Univ. of Nevada,
Reno.
B250 1129.2 Selective upregulation of genes for MMP3 and
MT-1 MMP by substance P in cardiac fibroblasts. H.M. Dehlin,
A. Monroe, M. Reimer, E. Manteufel and S. Levick. Med. Col.
of Wisconsin.
B251 1129.3 Ablation of MMP9 ameliorates epigenetic
modifications and mitigates diabetic cardiomyopathy. P.K.
Mishra, V. Chavali, N. Metreveli and S.C. Tyagi. Univ. of
Louisville.
B252 1129.4 MMP-9 dependent proteins regulate left
ventricular remodeling following myocardial infarction. L.E.
de Castro Bras, K.Y. DeLeon, A. Yabluchanskiy, Y. Ma,
G.V. Halade, K. Hakala, S.T. Weintraub and M.L. Lindsey.
Univ. of Texas Hlth. Sci. Ctr. at San Antonio and San Antonio
Cardiovasc. Proteomics Ctr.
B253 1129.5 Endurance exercise training attenuates fibrosis
and collagen cross-linking in myocardium of aged F344BNF1
rats. K.J. Wright, A. Betik, M. Thomas, R. Hepple and D.
Belke. McGill Univ., Victoria Univ., Australia, McMaster Univ.
and Univ. of Calgary, Canada.
B254 1129.6 Cardiac fibrosis and diastolic dysfunction are
highly correlated in a mouse chronic pressure-overload model.
A. Olzinski, W. Bao, D. DeLong, S. Lenhard, F. Wright, R.
Coatney, B. Jucker, S. Eisennagel, S. Needle, T. Wang and
C. Schnackenberg. GlaxoSmithKline.
B255 1129.7 Both collagen and elastin matrices are
remodeled in the failing ovine atria – a role for elastindegrading enzymes in atrial structural remodeling. M.A. Horn,
H.K. Graham, S.J. Borland, J.D. Clarke, K.M. Dibb and A.W.
Trafford. Univ. of Manchester.
B256 1129.8 Activation of proteases and changes in Na+-K+
ATPase subunits in hearts subjected to ischemia-reperfusion.
A.L. Müller, D.H. Freed and N.S. Dhalla. Univ. of Manitoba.
B257 1129.9 Doxycycline attenuates cardiac injury and
improves cardiac function with inhibition of myocardial matrix
metalloproteinase-2 in a swine model of hypoxia-reoxygenation.
J.R. LaBossiere, J-S. Pelletier, M. Ali, D. Bigam, R. Schulz
and P-Y. Cheung. Univ. of Alberta.
B258 1129.10 Analysis of mitochondrial MMP-2 and MMP-9
in the heart. B. Hughes, F. Fan, T. Simmen and R. Schulz.
Univ. of Alberta.
TUESDAYPHYSIOLOGY
B259 1129.11 The increase of mitochondrial DNA copy
number attenuates eccentric cardiac remodeling in volume
overload model. M. Ikeda, T. Ide, T. Fujino, Y. Hata, T. Takehara,
K. Onitsuka, T. Tobushi, K. Sakamoto, K. Saku, T. Kakino,
H. Tyynismaa, A. Suomalainen and K. Sunagawa. Kyushu
Univ., Japan and Univ. of Helsinki.
B260 1129.12 Molecular mechanisms of PDGF-D-induced
cardiac fibrogenesis. T. Zhao, W. Zhao, Y. Chen, V.S. Li and Y.
Sun. Univ. of Tennessee Hlth. Sci. Ctr., Memphis.
B261 1129.13 Identification of novel scleraxis gene targets in
cardiac myofibroblasts. R. Bagchi, P. Roche, R. Schweitzer
and M. Czubryt. Univ. of Manitoba and Oregon Hlth. & Sci.
Univ.
B262 1129.14 Autophagy in phenoconversion of differentiated
and undifferentiated fibroblasts. S. Gupta, M. Kavosh, S-R.
Chen, S. Ghavami, S. Rattan, T. Klonisch and I. Dixon. Univ.
of Manitoba.
B263 1129.15 The passive mechanical environment alters
the phenotype of cardiac fibroblasts. M. Galantowicz, T.A.
West, X. Zhang, R.C. Childers, K.J. Gooch, J.C. Weibel, M.J.
Cismowski and P.A. Lucchesi. Nationwide Children’s Hosp.
and The Ohio State Univ.
B264 1129.16 Anti-parstatin promotes angiogenesis and
ameliorates left ventricular dysfunction during pressure
overload. S. Givvimani, N. Narayanan, S.B. Pushpakumar
and S.C. Tyagi. Univ. of Louisville.
B265 1129.17 Absence of TRPV4 channels improves cardiac
function and remodeling following myocardial infarction and
transverse aortic constriction. R.K. Adapala, D.J. Luther, V.A.
Ohanyan, J. Luli, R. Thoppil, S. Paruchuri, W.M. Chilian, J.G.
Meszaros and C.K. Thodeti. Northeast Ohio Med. Univ. and
Univ. of Akron.
B266 1129.18 Angiotensin II-induced myocardial hypertrophy
and fibrosis are characterized by enhanced MMP-9 and
suppressed RECK expression. J.M. Siddesha, A.J. Valente,
S.S.V.P. Sakamuri and B. Chandrasekar. Tulane Univ. Sch. of
Med., Univ. of Texas Hlth. Sci. Ctr. at San Antonio and Southeast
Louisiana Veterans Hlth. Care Syst.
1130.MYOCARDIAL ISCHEMIA/MYOCARDIAL
METABOLISM I
Poster
Exhibit Halls A-B
B267 1130.1 Mechanical tissue resuscitation reduces
myocardial tissue injury following myocardial ischemiareperfusion. J.E. Jordan, J.J. Mays, J.E. Shelton, E.A.
Thompson, A.K. Bryant, M.R. Lane and M.J. Morykwas.
Wake Forest Sch. of Med.
B268 1130.2 The roles of mitochondrial Src tyrosine kinase
and zinc in nitric oxide-induced cardioprotection against
ischemia/reperfusion injury. Z. Xu, X. Liu, L. Zhang, Y. Kang, J.
Lou and Y. Zhu. Tianjin Med. Univ., China.
B269 1130.3 Novel fatty acyl CoA synthetase inhibitors –
new tools to study ischemia/reperfusion injury. N.R. Blakeman,
A.M. Prior, L. Pokhrel, D.H. Hua and M.T. Weis. Sch. of
Pharm., Texas Tech Univ. Hlth. Sci. Ctr. and Kansas State Univ.
B270 1130.4 Mechanical tissue resuscitation activates the
risk pathway and widens the therapeutic window for treating
acute myocardial infarction. J.E. Jordan, B.D. Pereira, M.J.
Morykwas, M.R. Lane, J.J. Mays, G. Colmer, C. Hollingsworth
and L.C. Argenta. Wake Forest Sch. of Med.
B271 1130.5 Evidence for pleiotropic cardioprotection by
the bradycardic agent ivabradine. P. Kleinbongard and G.
Heusch. Univ. Hosp. Essen, Germany.
B272 1130.6 Reactive oxygen species in saliva-related
acute myocardial infarction. M.C. Rubio, S. Puntarulo, P.
Gonzalez, C. Ramos, P. Lewin, F. Lifshitz, S. Friedman and
L. Nicolosi. Sch. of Dent., Hosp. Español., PRALIB, CONICET,
Sch. of Pharm. and Biochem., Univ. of Buenos Aires and Pediat.
Sunshine Acad. & Sansum Med. Res Inst., Santa Barbara.
B273 1130.7 Low-dose
intra-nasal
cocaine
causes
subclinical microvascular coronary ischemia in humans. M.
Nelson, S.V. Gurudevan, X. Tang, J. Lewis, J. Johannes, T.
Belcik, J.R. Lindner and R.G. Victor. Cedars-Sinai Med. Ctr.
and Oregon Hlth. & Sci. Univ.
B274 1130.8 Hemodynamic and bioenergetics of hearts
from obese adult mice overfed during early life. A.K. Vieira,
A.M. de Mattos, F.A. Neves, A.F. Bernardo, E.C. Cortez, L.R.
de Souza, G.L. Miranda, V.M. dos Santos, A.C.S. RodriguesCunha, É.P. Garcia-Souza, R. Sichieri and A.S. Moura. Rio
de Janeiro State Univ.
B275 1130.9 Reciprocal endothelial NO synthase Ser1177
phosphorylation and Thr495 dephosphorylation is key for
robust in vivo cardioprotection: therapeutic implication of a
novel ischemic preconditioning stimuli. M.A.H. Talukder, F.
Yang, C. Yang, Y. Nishijima, C-A. Chen, S. Varadharaj and
J.L. Zweier. Davis Heart and Lung Inst., The Ohio State Univ.
B276 1130.10 a1-Adrenergic receptor activation mimics
ischemic postconditioning. D.M. Janota and J. Yun. Northeast
Ohio Med. Univ. and Kent State Univ.
1131.NOVEL SIGNALING MOLECULES IN VASCULAR
INJURY AND INFLAMMATION (POSTERS)
Poster
Exhibit Halls A-B
B277 1131.1 Telomere
uncapping
causes
cellular
senescence and inflammation in arteries: implications for
arterial aging. R.G. Morgan, S.J. Ives, L.A. Lesniewski,
R.M. Cawthon, R.H.I. Andtbacka, R.D. Noyes, E.L. Denchi,
R.S. Richardson and A.J. Donato. Univ. of Utah, George E.
Wahlen DVA Med. Ctr. and The Scripps Res. Inst.
B278 1131.2 Ga13 targeting of VE-cadherin mediates
disassembly of adherens junctions and endothelial permeability.
H. Gong, X. Gao, M.R. Siddiqui, A. Garcia, M. Bonini, S.M.
Vogel and A.B. Malik. Univ. of Illinois at Chicago.
B279 1131.3 Stathmin modulates microtubule dynamics
and controls Rho signaling and vascular permeability. A.A.
Birukova, N. Sarich, T. Wu and X. Tian. Univ. of Chicago.
B280 1131.4 Novel Rap1-dependent regulator of endothelial
cell junctions afadin mediates protective effects by oxidized
phospholipids in the models of acute lung injury. K.G. Birukov,
N. Sarich, O. Dubrovskyi and N. Zebda. Univ. of Chicago.
391
T
U
E
PHYSIOLOGYTUESDAY
B281 1131.5 LPS induces pp60c-srcmediated tyrosine
phosphorylation of Hsp90 in lung vascular endothelial cells
and mouse lung. N. Barabutis, V. Handa, C. Dimitropoulou,
R. Rafikov, C. Snead, S. Kumar, A. Joshi, G. Thangjam, D.
Fulton, S.M. Black, V. Patel and J.D. Catravas. Georgia Hlth.
Sci. Univ.
B282 1131.6 Post-treatment with the heat shock protein 90
inhibitor, 17-AAG, reduces pulmonary inflammation, hyperpermeability and airway dysfunction associated with LPSinduced acute lung injury in mice. C. Dimitropoulou, A. Joshi,
N. Barabutis, M. Shaw, V. Patel and J.D. Catravas. Georgia
Hlth. Sci. Univ.
B283 1131.7 ER stress regulator BiP and mitochondrial
chaperone mortalin differentially regulate RelA/p65 activation
and endothelial cell inflammation. A. Leonard, A. Rahman and
F. Fazal. Univ. of Rochester Med. Ctr.
B284 1131.8 Regenerative cerebral arteriogenesis is
induced by GM-CSF and inhibited by anti-inflammatory
cardiovascular medications. A.B. Persson, A. Duelsner, N.
Gatzke and I.R. Buschmann. Charité Univ. Hosp. Berlin.
B285 1131.9 Role of sphingolipids in fibrinogen-induced
cerebrovascular permeability. N. Muradashvili, S.J.
Khundmiri, R. Tyagi, M-J. Lee and D. Lominadze. Univ. of
Louisville and Wayne State Univ.
B286 1131.10 Novel mitochondrial mechanisms mediate
enhanced vasodilation of rat middle cerebral arteries to
mitochondrial depolarization following ischemia-reperfusion
injury. I. Rutkai, E.A. Wappler, P.V.G. Katakam, D. Liu and
D.W. Busija. Tulane Univ. Sch. of Med.
B287 1131.11 Activation of formyl peptide receptors induces
relaxation and reduces contraction in resistance arteries. C.F.
Wenceslau, C.G. McCarthy, S. Goulopoulou and R.C. Webb.
B288 1131.12 Connexin 40 is necessary for recovery of
ischemic hindlimb perfusion—inflammation and gender
considerations. J.M. Burt, L.L. Querin, J.R. Oulton and J.S.
Fang. Univ. of Arizona.
B289 1131.13 FoxO induced inhibition of secreted molecule
signaling pathways: role in promoting angiostasis in the
ischemic muscle. E.A. Roudier, M. Milkiewicz and T.L. Haas.
York Univ., Canada and Pomeranian Med. Univ., Poland.
B290 1131.14 Intravenous infusion of Bendavia during renal
revascularization attenuates cardiac injury and dysfunction in
swine renovascular hypertension. B.J. Williams, A. Eirin, B.
Ebrahimi, X. Zhang, J.R. Woollard, H. Tang, K.L. Jordan, J.A.
Crane, A. Lerman and L.O. Lerman. Mayo Clin. and Univ. of
California, Irvine Sch. of Med.
B291 1131.15 Myloid differentiation factor 88 does not
contribute to hypertension or endothelial dysfunction produced
by angiotensin II. J.R. Gomolak, J.L. Faulkner and S.P.
Didion. Univ. of Mississippi Med Ctr.
B292 1131.16 Antagonistic effects of mineralocorticoid
receptor blockade on the vascular reactivity of male and female
leptin-sensitized mice. A-C. Huby, M.L. Tremblay and E.J.
Belin de Chantemele. Georgia Hlth. Sci. Univ. and McGill Univ.
B293 1131.17 Immune cell-mediated regulation of lymphatic
contractility during inflammation. S. Chakraborty, W. Wang,
D.C. Zawieja and M. Muthuchamy. Col. of Med., Texas A&M
Hlth. Sci. Ctr.
B294 1131.18 PPARg-mediated modulation of acroleininduced oxidative stress: role of NAD(P)H oxidase subunit
gp91phox. N. Chug, K. Marek, Z. Yousefipour and M. Newaz.
Chicago State Univ. and Texas Southern Univ.
392
1132.EXERCISE TRAINING RESPONSES
Poster
Exhibit Halls A-B
B295 1132.1 Applying lactate sampling to interval training in
CAD. J.W. Christle, A. Pressler, U. Wisloff and M. Halle. Tech
Univ. Munich and Norwegian Univ. of Sci. and Technol.
B296 1132.2 Gluconeogenesis and hepatic glycogenolysis
during exercise at the lactate threshold. C-A.W. Emhoff, L.A.
Messonnier, M.A. Horning, J.A. Fattor, T.J. Carlson and
G.A. Brooks. Univ. of California, Berkeley and Univ. de Savoie,
France.
B297 1132.3 Effects of aging and low-load balance exercise
on the expression of neurotrophins and glutamate receptors in
the mouse brain. H. Maejima, N. Kanemura, T. Kokubun, K.
Murata and K. Takayanagi. Teikyo Univ. of Sci. and Saitama
Prefect. Univ., Japan.
B298 1132.4 Determination of exercise modality employing
serum metabolomics profiling in type 2 diabetes: relation to
clinical outcomes. J.J. Yang, M. Palmnas, J. Su, L. Kirtiadi, H.
Vogel, R. Sigal and J. Shearer. Univ. of Calgary, Canada.
B299 1132.5 Muscle perilipin 3 is reduced using in vitro and
in vivo exercise models and negatively associated with exercise
lipid oxidation. J.D. Covington, J.E. Galgani, A.C. Rustan, Z.
Zhang, C. Moro, S.R. Smith, E. Ravussin and S. Bajpeyi.
Pennington Biomed. Res. Ctr., Baton Rouge, Pontifical Catholic
Univ. of Chile, Univ. of Oslo, Inst. of Metab. and Cardiovasc.
Dis., Toulouse, Florida Hosp.-TRI, Orlando and Univ. of Texas
at El Paso.
B300 1132.6 Low volume high intensity training improves
insulin sensitivity but reduces aerobic power in trained middleaged runners. K. Winding, L.S. Hansen, T.A. Knudsen, Y.
Hellsten, S.P. Mortensen and B.K. Pedersen. Copenhagen
Univ. Hosp. and Univ. of Copenhagen.
B301 1132.7 Low-volume high intensity interval training
induces a modest inflammatory response in young active
males. C.S. John, M.M. Lawrence, R.A. Shanely, R.A.
Battista and K.A. Zwetsloot. Appalachian State Univ., Boone
and Kannapolis, NC.
B302 1132.8 Effects of resistance interval and constant
training on muscular hemodynamic kinetics in sedentary men.
C-L. Chiang and J-S. Wang. Natl. Taiwan Sport Univ. and
Chang Gung Univ., Taiwan.
B303 1132.9 Resistance exercise training reverses agerelated impairments in macro- and microvascular blood flow
and the associated blunted muscle protein synthesis response
to nutrition. B. Phillips, P. Atherton, K. Varadhan, M. Limb, M.
Rennie, K. Smith and J. Williams. Sch. of Grad. Entry Med.
and Hlth. and Sch. of Biomed. Sci., Univ. of Nottingham.
B304 1132.10 Basal expression of VEGF does not correlate
with loss of skeletal muscle capillarity with detraining. S.
Olenich, K. Roberts, G. Audet and I.M. Olfert. West Virginia
Univ.
B305 1132.11 Effect of aerobic interval training on erythrocyte
rheological and hemodynamic functions in heart failure patients
with anemia. J-S. Wang. Chang Gung Univ., Taiwan.
B306 1132.12 Effect of combined aerobic and resistance
exercise training on platelet adhesiveness under shear flow in
sedentary men. Y-C. Chen and J-S. Wang. Chang Gung Univ.,
Taiwan.
TUESDAYPHYSIOLOGY
B307 1132.13 Effects of combined aerobic and resistance
exercise training on apoptosis and autophagy of CD4+
lymphocytes in sedentary men. Y-H. Lin and J--S. Wang.
Chang Gung Univ., Taiwan.
B308 1132.14 Effect of combined aerobic and resistance
exercise training on circulating progenitor cells in sedentary
men. C-P. Lin and J-S. Wang. Chang Gung Univ., Taiwan.
B309 1132.15 Aerobic interval training improves mobilization
and migratory capacity of endothelial progenitor cells in
sedentary men. H-H. Tsai and J-S. Wang. Chang Gung Univ.,
Taiwan.
B310 1132.16 Hospital-based supervised aerobic training
effectively improves ventilation efficiency and cardiac output
power in patients with systolic heart failure. C-W. Ho, S-C.
Huang, S-C. Cheng, C-H. Chan and J-S. Wang. Chang Gung
Univ., Taiwan.
B311 1132.17 Different physiological adaptations to aerobic
interval training between heart failure patients with reduced
and preserved ejection fractures. T-C. Fu and J-S. Wang.
Chang Gung Memory Hosp. and Chang Gung Univ., Taiwan.
B312 1132.18 Effects of obesity and exercise training on
testosterone levels in male rats. N. Arsenis, B. Disanzo and
T. You. Univ. of Massachusetts Boston and Univ. at Buffalo,
SUNY.
B313 1132.19 The effects of combined exercise on body
compositions and blood lipid profiles in Korean obese women.
H.M. Jin and P.J. Kim. Grad. Sch. of Sport Sci., Kyonggi Univ.,
South Korea.
B314 1132.20 Adipose tissue decrease by exercise training
is associated with blood pressure reduction in old fructose-fed
female rats. J.F. Machi, N. Bernardes, D.S. Dias, F. Santos,
I.C. Moraes-Silva, M. Sartori, R.B. Wichi, K. De Angelis and
M.C. Irigoyen. Heart Inst. and Fac. of Med., Univ. of São Paulo,
Nove de Julho Univ., São Paulo and Fed. Univ. of Sergipe,
Brazil.
B315 1132.21 Sex-differences in the effects of isometric
handgrip training on resting blood pressure and resistance
vessel function. M.B. Badrov, S.R. Freeman, P.J. Millar and
C.L. McGowan. Univ. of Windsor, Canada and Toronto Gen.
Hosp.
B316 1132.22 Aquatic training reduces exercise blood
pressure and increases muscle eNOS. S.F. Crouse, N.P.
Greene, B.S. Lambert, A.T. Carradine, D. Joubert, S.
Riechman and J. Fluckey. Texas A&M Univ. and Univ. of
Virginia.
B317 1132.23 Physiological and biomechanical analysis of a
foot-tapping device. L. Brilla, D.N. Suprak and R. Callahan.
Western Washington Univ.
B318 1132.24 Modeling exercise effects on cardiovascular
fitness using STELLA. A.C. Sanders and R.T. Davidson.
Logan Univ., MO.
B319 1132.25 Block periodization training in Navy SEAL
Operators: effect of 12 weeks on salivary hormones. J. Oliver,
A.C. Zimmer, D. Wood, J.P. Abt, T.C. Sell and S.M. Lephart.
Univ. of Pittsburgh and Naval Special Warfare, Pittsburgh.
B320 1132.26 Overall stress response is reduced in U.S.
marines following infantry training. K. Kelly, A. Jensen, B.
Niederberger, R. Congalton and R. Jaworski. Naval Hlth.
Res. Ctr., San Diego and Marine Corps Systs. Command,
Quantico, VA.
B321 1132.27 Exercise training in childhood cancer survivors
with subclinical cardiomyopathy. W.A. Smith, K.K. Ness, V.M.
Joshi, M.M. Hudson, L.L. Robison and D.M. Green. St. Jude
Children’s Res. Hosp. and Univ. of Mississippi.
B322 1132.28 Impact of exercise training on cardiovascular
risk and anti-risk factors in adolescent boys. M. Koozehchian,
F. Nazem and R.B. Kreider. Texas A&M Univ. and Bu Ali Sina
Univ., Iran.
B323 1132.29 Enhanced spontaneous cage activity induced
by continuous low intensity spinal cord epidural stimulation in
complete spinal cord transected adult rats. P. Gad, J. Choe, M.
Rath, P. Shah, Y. Gerasimenko, H. Zhong, R.R. Roy and V.R.
Edgerton. UCLA.
B324 1132.30 Effect of unilateral E-stim on strength in a
contralateral untrained limb after bilateral strength training. S.
LoRusso, N. Barr, W. Hanik, J. Hazen, A. Strittmatter and T.
Tocco. Saint Francis Univ., PA.
B325 1132.31 The changes of lower limb muscle function and
gait with application of aquatic rehabilitation exercise in Korean
stroke patients. H.M. Jin, I.G. Jeon and H.E. Kim. Kyonggi
Univ. and Dong-eui Univ., South Korea.
B326 1132.32 Endurance training promotes upregulation in
microRNA-206 on blood and in human skeletal muscle. C.R.
Alves, J.R.L. Junior, G.B. Alves, C.E. Negrão and E.M.
Oliveira. Univ. of São Paulo, Heart Inst. and Sch. of Phys.
Educ.and Sport.
B327 1132.33 Influence of sprint interval training on skeletal
muscle mitochondria as determined by high-resolution
respirometry. J.W. Beals, C.H. Le, R.L. Scalzo, S.E. Binns,
G.R. Giordano, A.L. Klochak, H.L. Paris, K.E. Sevits, C. Bell
and A.J. Chicco. Colorado State Univ.
1133.MICROVASCULAR RESPONSES AND
THERMOREGULATORY CONTROL IN NORMAL
AND CLINICAL POPULATIONS (POSTERS)
Poster
Exhibit Halls A-B
B328 1133.1 Endothelium-dependent
vasodilation
in
young, obese adults: contribution of NOS. G.L. Peltonen,
R.E. Johansson, J.W. Harrell, J.K. Limberg, M.K. Crain, J.J.
Sebranek, B.J. Walker, E.W. Marlowe and W.G. Schrage.
Univ. of Wisconsin-Madison.
B329 1133.2 Reduced contribution of NOS and CO to
beta adrenergic vasodilation in obesity. M.K. Crain, R.E.
Johansson, G.L. Peltonen, J.W. Harrell, W.G. Schrage, J.K.
Limberg, J.J. Sebranek, B.J. Walker and M.W. Eldridge.
Univ. of Wisconsin-Madison and Univ. of Wisconsin Sch. of
Med. and Publ. Hlth.
B330 1133.3 Heat production per unit mass determines
the core temperature response to exercise in compensable
conditions. M.N. Cramer and O. Jay. Univ. of Ottawa Sch. of
Human Kinet.
B331 1133.4 Improved thermoregulatory and autonomic
responses contribute to reduced fatigue and faster recovery
from exertional heat stress by sympatholytic treatment with
clonidine. H.M. Stauss, N. Choudhary, A.M. Moss and K.C.
Kregel. Univ. of Iowa.
B332 1133.5 Effects of prior exercise on skin blood flow and
insulation during subsequent moderate cold exposure. M.G.
Spitz, J.W. Castellani, M.J. Alinovi and D.W. DeGroot. U.S.
Army Res. Inst. of Envrn. Med., Natick, MA and U.S. Army Publ.
Hlth. Command, Aberdeen, MD.
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B333 1133.6 Whole-body sweat sensitivity in burn survivors
following heat acclimation. Z.J. Schlader, R.A.I. Lucas, P.
James, M.S. Ganio and C.G. Crandall. Presbyterian Hosp. of
Dallas, Cardiff Metro. Univ., U.K. and Univ. of Arkansas.
B334 1133.7 Dietary nitrate supplementation augments
cutaneous reflex vasodilation in healthy humans. E.L. Levitt,
J.T. Keen and B.J. Wong. Kansas State Univ.
B335 1133.8 Effects of dietary nitrate supplementation
on NO-mediated vasodilation during local heating in healthy
humans. J.T. Keen, E.L. Levitt and B.J. Wong. Kansas State
Univ.
B336 1133.9 Microvascular function is reduced in
normotensive salt-sensitive individuals independent of dietary
sodium intake. J.J. DuPont, J.L. Greaney, E.M. Matthews,
S.L. Lennon-Edwards, W.B. Farquhar and D.G. Edwards.
Univ. of Delaware.
B337 1133.10 ETA subtype receptor sensitivity to testosterone
contributes to microvascular dysfunction in PCOS. N.
Stachenfeld, M. Wenner and H.S. Taylor. John B. Pierce Lab.,
Yale Sch. of Med. and Univ. of Delaware.
B338 1133.11 Non-uniform age-related decrements in
regional sweating and skin blood flow. C.J. Smith, L.M.
Alexander and W.L. Kenney. Penn State.
B339 1133.12 Acute oral sapropterin (Kuvan®) augments
NO-dependent reflex vasodilation in aged human skin. A.E.
Stanhewicz, L.M. Alexander and W.L. Kenney. Penn State.
B340 1133.13 Total/HDL cholesterol ratio predicts impaired
NO-dependent vasodilation in human skin. J.D. Dahmus, D.H.
Craighead, W.L. Kenney and L.M. Alexander. Penn State.
B341 1133.14 Characterization of the cutaneous blood flowlocal temperature response through its entire range. R.S.
Bruning, L.M. Alexander and W.L. Kenney. Penn State.
B342 1133.15 A novel look at KIR channels and potassium in
human skin. M.A. Francisco, N. Fujii, C.T. Minson and V.E.
Brunt. Univ. of Oregon.
B343 1133.16 A complex interplay between NO, EDHFs, and
KIR channels in cutaneous active vasodilation. V.E. Brunt, N.
Fujii and C.T. Minson. Univ. of Oregon.
B344 1133.17 Endothelium-dependent cutaneous vasodilation in young smokers: role of endothelial-derived
hyperpolarizing factors. N. Fujii, V.E. Brunt, M.A. Francisco
and C.T. Minson. Univ. of Oregon.
1134.EPIGENETICS AND EXERCISE (POSTERS)
Poster
Exhibit Halls A-B
B345 1134.1 Endurance training changes the DNA
methylation pattern in human skeletal muscle. M.E. Lindholm,
F. Marabita, D. Gomez-Cabrero, H. Fischer, J. Tegnér and
C.J. Sundberg. Karolinska Inst., Stockholm and Huddinge.
B346 1134.2 HDZCs are O-GlcNAc modified and OGT
O-GlcNAcylation is decreased with acute exercise. H.M.
Medford and S.A. Marsh. Washington State Univ.
B347 1134.3 Exercise during pregnancy attenuates prenatal
high-fat diet-induced hypermethylation of the Pgc-1a gene
and protects against age-induced glucose intolerance in the
offspring. R.C. Laker, T. Lillard, M. Okutsu, J. Connelly and
Z. Yan. Univ. of Virginia.
394
B348 1134.4 Maternal exercise during pregnancy improves
glucose metabolism of offspring. K.I. Stanford, M-Y. Lee, K.M.
Getchell, M.F. Hirshman and L.J. Goodyear. Joslin Diabetes
Ctr.
B349 1134.5 Effects of in utero heat stress on postnatal thermoregulation. J.S. Johnson, J. Ross, J. Selsby,
R. Boddicker, M. Lucy, T. Safranski, R. Rhoads and L.
Baumgard. Iowa State Univ., Univ. of Missouri-Columbia and
VPI and State Univ.
B350 1134.6 Exercise ameliorates high fat diet-mediated
inflammation, DNA methylation and heart failure in female
mice. V. Chavali, J.M. Harris, S. Givvimani, N. Qipshidze,
L.A. Murphy, G. Tyagi, N. Metreveli, S.C. Tyagi and P.K.
Mishra. Univ. of Louisville.
1135.CENTRAL NERVOUS SYSTEM MODULATION
OF CARDIORESPIRATORY RESPONSES TO
HYPOXIA (POSTERS)
Poster
Exhibit Halls A-B
B351 1135.1 Rett syndrome mutation MeCP2 T158A affects
hypoxic ventilatory response in mice. J.M. Bissonnette, S.J.
Knopp and Z. Zhou. Oregon Hlth. & Sci. Univ. and Univ. of
Pennsylvania.
B352 1135.2 Recruitment of serotonergic responses in
cardiac vagal neurons during hypoxia and hypercapnia. L.A.
Weigand and D. Mendelowitz. The George Washington Univ.
B353 1135.3 Central modulation of arterial chemo-baroreflex
control by propofol during severe arterial hypoxia in the rabbit.
A.W. Quail, D.B. Cottee, R. Roach and S.W. White. Univ. of
Newcastle and Hunter Med. Res. Inst., Australia.
B354 1135.4 Knockdown of tyrosine hydroxylase in the
nucleus of the solitary tract reduces elevated blood pressure
during chronic intermittent hypoxia. C.S. Bathina, A. Rajulapati,
M. Franzke, K. Yamamoto and S. Mifflin. Univ. of North Texas
Hlth. Sci. Ctr.
B355 1135.5 Short-term sustained hypoxia affects synaptic
transmission in the nucleus tractus solitarius neurons of
juvenile rats. D. Accorsi-Mendonça, C.E.L. Almado and B.H.
Machado. Sch. of Med. of Ribeirão Preto, Univ. of São Paulo.
B356 1135.6 Changes in ionic currents of respiratory
neurons produce sympathetic overactivity in chronic intermittent
hypoxic rats. D.J.A. Moraes, M.P. da Silva, D.B. Zoccal, W.A.
Varanda and B.H. Machado. Sch. of Med. of Ribeirão Preto,
Univ. of São Paulo.
B357 1135.7 Sympathetic nerve activity response to acute
intermittent hypoxia and development of sympathetic longterm facilitation. A.Y. Fong, A.M. Hammond, T. Xing and P.M.
Pilowsky. Macquarie Univ., Australia.
B358 1135.8 Intermittent hypoxia induces leptin signaling
in the carotid body. J. Ciriello and S.A. Messenger. Univ. of
Western Ontario.
B359 1135.9 Ventilatory instability persists 1 week after
lipopolysaccharide exposure in newborn rat pups. A.V. Mason,
E. Kostuk, M. Shirahata and E.B. Gauda. Johns Hopkins Sch.
of Med. and Johns Hopkins Bloomberg Sch. of Publ. Hlth.
B360 1135.10 Developmental hyperoxia attenuates hypoxic
ventilatory depression in neonatal rats. R.W. Bavis, S.H.
Grandgeorge and C.B. Hill. Bates Col.
TUESDAYPHYSIOLOGY
B361 1135.11 Perinatal sulfur dioxide exposure alters
brainstem parasympathetic control of heart rate. A.L. Woerman
and D. Mendelowitz. George Washington Univ.
B362 1135.12 Endogenous hydrogen sulfide in the rostral
ventrolateral medulla mediates ventilatory response induced
by hypoxia. A.F. Donatti, M. Kwiatkoski, R.N. Soriano, E.C.
Carnio and L.G.S. Branco. Univ. of São Paulo, Ribeirão Preto.
B363 1135.13 Measuring hydrogen sulfide at the cellular and
sub-cellular level with fluorescent nanoparticles. E.R. DeLeon,
M. Galvan, S.S. Bohlson and K.R. Olson. Indiana Univ. Sch.
of Med. South Bend and Univ. of Notre Dame.
B364 1135.14 HIF-1a increases glutamatergic NMDA
receptors in the PVN during chronic heart failure. N. Sharma,
C. Cunningham, X. Liu, H. Zheng and K. Patel. Univ. of
Nebraska Med. Ctr.
B365 1135.15 Autonomic function assessed with heart rate
variability in Everest climbers. J.W. Marck, A. Issa, B. Taylor,
D. Summerfield, A. Kasak and B. Johnson. Mayo Clin. and
TNO, The Hague.
1136.VASCULAR RESPONSES TO EXERCISE AND
ENVIRONMENTAL STRESS
Poster
Exhibit Halls A-B
B366 1136.1 Plasticity in the microvasculature of conditioned
weight lifters after acute high pressure stress. M.J. Durand,
S.A. Phillips and D.D. Gutterman. Med. Col. of Wisconsin and
Univ. of Illinois at Chicago.
B367 1136.2 Is sympathetic restraint of skeletal muscle
blood flow present during exercise? Z. Barrett-O’Keefe, S.J.
Ives, J.D. Trinity, M.A.H. Witman, M.J. Rossman, H.J. Groot,
D.E. Morgan, B. Gmelch, R.S. Richardson and D.W. Wray.
Univ. of Utah and VA Med. Ctr.
B368 1136.3 Ascorbic acid inhibits histamine-receptor
mediated sustained post-exercise vasodilation in humans. S.A.
Romero, J.M. Kono and J.R. Halliwill. Univ. of Oregon.
B369 1136.4 Nitric oxide-mediated vascular function in
response to limb movement: the impact of age. J.D. Trinity, H.J.
Groot, G. Layec, M.J. Rossman, S.J. Ives, D.E. Morgan, B.S.
Gmelch, A. Bledsoe and R.S. Richardson. VA Med. Ctr. and
Univ. of Utah.
B370 1136.5 Contributions of nitric oxide and prostaglandins
to exercise hyperemia in young obese adults. R.E. Johansson,
J.W. Harrell, J.K. Limberg, M.K. Crain, C.L. Rousseau, P.A.
Yanke, J.J. Sebranek, B.J. Walker, M.W. Eldridge and W.G.
Schrage. Sch. of Med. and Publ. Hlth., Univ. of WisconsinMadison.
B371 1136.6 The effect of short-term exercise training and
nitric oxide on the adaptation of femoral vascular conductance
at the onset of contraction. T. Just, N.G. Jendzjowsky and
D.S. DeLorey. Univ. of Alberta.
B372 1136.7 Contribution of nitric oxide in the contractioninduced rapid vasodilation in young and older adults. D.P.
Casey, B.G. Walker, S.M. Ranadive, J.L. Taylor and M.J.
Joyner. Mayo Clin.
B373 1136.8 Sex related differences in vasodilator
responsiveness to hypoxia at rest and during exercise. J.R.A.
Shepherd, M.J. Joyner and D.P. Casey. Mayo Clin.
B374 1136.9 Endogenous estrogen enhances brachial blood
conductance during dynamic handgrip in young healthy and
metabolic syndrome women. R. Restaino, T. Schwermann, A.
Blankenship and M.A. Barlow. Eastern New Mexico Univ.
B375 1136.10 Chronic depressive symptoms and gender:
impact on conduit vascular outcomes. S.C. Stanley, J.T.
Butcher, S.J. Frisbee, A.C. d’Audiffret and J.C. Frisbee.
West Virginia Univ.
B376 1136.11 A single bout of aerobic exercise prevents the
transient endothelial dysfunction induced by mental stress in
men with metabolic syndrome. A.R.K. Sales, I.A. Fernandes,
N.G. Rocha, V.P. Garcia, L.S. Costa, B.M. Silva and A.C.L. da
Nóbrega. Fluminense Fed. Univ., Brazil.
B377 1136.12 Five days of reduced physical activity
selectively impairs endothelial function of the inactive limbs. L.
Boyle, D. Credeur, N. Jenkins, J. Padilla, J. Thyfault and P.
Fadel. Univ. of Missouri-Columbia.
B378 1136.13 The effect of L-arginine supplementation
and voluntary wheel running on vascular function in rats with
chronic kidney disease. C.R. Martens, J.M. Kuczmarski, S.
Lennon-Edwards and D.G. Edwards. Univ. of Delaware.
B379 1136.14 Regulation of antioxidant enzyme expression
in response to exercise in skeletal muscles of dyslipidemic
mice. A.Q. Nguyen and E. Thorin. Montreal Heart Inst. and
Univ. of Montreal.
B380 1136.15 Role of vascular dysfunction in prostate tumor
perfusion during exercise. D.J. McCullough, D.W. Siemann
and B.J. Behnke. Univ. of Florida.
B381 1136.16 The effects of continuous-flow left ventricular
assist devices on peripheral vascular function. M.A.H. Witman,
H.J. Groot, J.R. Gifford, J.D. Trinity, J. Stehlik, S.G. Drakos
and R.S. Richardson. Univ. of Utah and Salt Lake City VA
Med. Ctr.
B382 1136.17 Investigating relationships between arterial
stiffness and collagen turnover in humans. L. Cotie, K. Currie,
J. Totosy de Zepetnek, A. Josse, G. McGill, S. Phillips and
M. MacDonald. McMaster Univ., Canada and Univ. of Toronto.
B383 1136.18 Alterations in the coagulation and fibrinolytic
systems following an ultra-marathon. B.R. Kupchak, B.M.
Volk, L. Kunces, L. Phinney, M.D. Hoffman, S.D. Phinney
and J.S. Volek. Univ. of Connecticut, UCLA, Univ. of California
Davis Med. Ctr., VA Northern California Hlth. Care Syst. and
Univ. of California, Davis.
B384 1136.19 Coronary blood flow during cold air breathing:
mechanistic insights using pharmacological blockade. M.D.
Muller, Z. Gao, J.L. Mast, U.A. Leuenberger and L.I. Sinoway.
Penn State Col. of Med.
B385 1136.20 Adenosine receptor inhibition attenuates
cutaneous vasoconstriction during whole-body cooling. G.P.
Kenny, R. McGinn, B. Swift and D. Gagnon. Sch. of Human
Kinetics, Univ. of Ottawa.
1137.CONTROL OF BREATHING: CHEMORECEPTION
Poster
Exhibit Halls A-B
B386 1137.1 Carbonic anhydrase activity underlies spike
frequency adaptation in avian intrapulmonary chemoreceptors.
K.L. Sheridan, J-G. Lonjaret and S.C. Hempleman. Northern
Arizona Univ.
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B387 1137.2 Two potassium-channel blockers differently
affect afferent signal of avian intrapulmonary chemoreceptors.
J-G. Lonjaret, K.L. Sheridan and S.C. Hempleman. Northern
Arizona Univ.
B388 1137.3 Pulmonary neuroendocrine H146 cells as
hypercapnic sensors. K. Ludlow and J. Buttigieg. Univ. of
Regina, Canada.
B389 1137.4 Changes in expression and activity of MnSOD
and CuZnSOD in carotid body and adrenal medullary cells of
rats exposed to chronic intermittent hypoxia. E. Moya, C.R.
Varela, P. Arias and R. Iturriaga. Pontifical Catholic Univ. of
Chile.
B390 1137.5 Key role for the multimodal CaSRr in
pulmonary neuroepithelial body microenvironment physiology.
R. Lembrechts, I. Brouns, K. Schnorbusch, I. Pintelon, P.J.
Kemp, J-P. Timmermans, D. Riccardi and D. Adriaensen.
Univ. of Antwerp, Belgium and Sch. of Biosci., Cardiff Univ.,
U.K.
B391 1137.6 A fetal mouse lung slice model for molecular
live cell imaging of the pulmonary neuroepithelial body
microenvironment. K. Schnorbusch, I. Brouns, R. Lembrechts,
I. Pintelon, J-P. Timmermans and D. Adriaensen. Univ. of
Antwerp, Belgium.
B392 1137.7 Carotid
body
denervation
attenuates
oscillations in respiratory rate and sympathetic nerve activity,
and decreases apnea/hypopnea index in congestive heart
failure. N.J. Marcus, R. Del Rio and H.D. Schultz. Univ. of
Nebraska Med.Ctr.
B393 1137.8 GAL-021 increases CO2-chemosensitivity at
doses that do not stimulate minute ventilation. S.M. Baby, F.J.
Golder, A.P. Kennedy, S. Peng and D.E. McIntyre. Galleon
Pharmaceuts. Inc., Horsham, PA.
B394 1137.9 Medullary raphé transcriptome comparisons
among inbred rat strains differing in ventilatory sensitivity to
CO2. M.R. Hodges, C. Yang, G.C. Mouradian, P. Liu and M.
Liang. Med. Col. of Wisconsin.
B395 1137.10 Isoflurane stimulates firing frequency and
masks chemosensitivity of CO2-inhibited GABAergic neurons
in situ. S.L. Johansen, K.E. Iceman, G.B. Richerson and
M.B. Harris. Univ. of Alaska Fairbanks and Univ. of Iowa.
B396 1137.11 Chemosensitive neurons in the retrotrapezoid
nucleus express SK channels with low Ca2+ affinity. X. Chen,
J. Hawryluk, A.V. Tzingounis and D.K. Mulkey. Univ. of
Connecticut.
B397 1137.12 Effects of leptin in the retrotrapezoid nucleus
on CO2-sensitivity and respiration. M. Bassi, W.I. Furuya, J.V.
Menani, D.S. Colombari, J.M. do Carmo, A. da Silva, J.E.
Hall, I.C. Wenker, D. Mulkey and E. Colombari. São Paulo
State Univ., Araraquara, Univ. of Mississippi Med. Ctr. and Univ.
of Connecticut.
B398 1137.13 Role of purinergic neurotransmission in
different brainstem CO2-chemoreceptor regions. I.C. Wenker,
C.R. Sobrinho, A.C. Takakura, T.S. Moreira and D.K. Mulkey.
Univ. of Connecticut and Univ. of São Paulo.
B399 1137.14 Chemosensory control by purinergic signaling
within the retrotrapezoid nucleus in conscious rats. B.F. Barna,
A.C. Takakura, D.K. Mulkey and T.S. Moreira. Univ. of São
Paulo and Univ. of Connecticut.
B400 1137.15 Purinergic signaling in the retrotrapezoid
nucleus contributes to central and peripheral chemoreflexes
by divergent mechansims. T.S. Moreira, C.R. Sobrinho, I.C.
Wenker, D.K. Mulkey and A.C. Takakura. Univ. of São Paulo
and Univ. of Connecticut.
396
B401 1137.16 ATP acts via P2Y1 receptors in the preBötzinger
complex in vivo to attenuate the secondary hypoxic respiratory
depression. V. Rajani, J.D. Zwicker, S. Pagliardini and G.D.
Funk. Univ. of Alberta.
B402 1137.17 Increased respiratory rhythm and O2 and CO2
chemosensitivity in juvenile rats submitted to perinatal protein
undernutrition. J.H. Costa-Silva, J.L.B. Alves, V.O. Nogueira,
G.B. Oliveira, G.S.F. Da Silva, A.G. Wanderley and C.V.G.
Leandro. Fed. Univ. of Pernambuco, Vitoria de Santo Antão
and Recife and Univ. of São Paulo, Ribeirão Preto.
B403 1137.18 Hypoglycemia-induced hyperpnoea: a role for
epinephrine and the carotid body? E.L. Thompson, C.J. Ray,
A. Coney and P. Kumar. Univ. of Birmingham, U.K.
B404 1137.19 Consequences of a maternal vitamin B6
deficiency on hypercapnic response in rat pups. J.L. St.
Laurent, K. Iceman and M.B. Harris. Univ. of Alaska Fairbanks.
B405 1137.20 The origin of air breathing in vertebrates: turn
(on) your head and cough. M. Hoffman, B.E. Taylor and M.B.
Harris. Univ. of Alaska Fairbanks.
B406 1137.21 Intermittent
hypercapnia-induced
GABAergic plasticity sufficiently enhances ventilatory CO2/
pH chemosensitivity to overcome serotonergic dysfunction.
B.P. Mosher, B.E. Taylor and M.B. Harris. Univ. of Alaska
Fairbanks.
B407 1137.22 Medullary raphé chemosensory amplifier
interneurons are mediated by serotonin/substance P and
GABA-synthesizing neurons in situ. K.E. Iceman and M.B.
Harris. Univ. of Alaska Fairbanks.
B408 1137.23 Ionotropic but not metabotropic glutamatergic
receptors in the locus coeruleus modulate the hypercapnic
ventilatory response in unanesthetized rats. M.B. Dias, C.L.
Taxini, C.C.I. Puga, L.H. Gargaglioni and K.C. Bícego. São
Paulo State Univ., Botucatu, Jaboticabal and IBILCE, São Jose
do Rio Preto, Brazil.
B409 1137.24 Hypercapnic acidosis increases glutamatergic
but decreases GABAergic input to chemosensitive neurons
from the caudal nucleus tractus solitarius from neonatal rats.
K-Y. Li and R.W. Putnam. Wright State Univ. Boonshoft Sch.
of Med.
B410 1137.25 Accelerators and brakes in CO2 chemosensitive
neurons. M.C. Quintero, J.M. Cordovez and R.W. Putnam.
Los Andes Univ., Colombia and Wright State Univ.
B411 1137.26 Brain-derived erythropoietin modulates the
hypercapnic ventilatory response during early postnatal life. J.
Soliz. Laval Univ., Canada.
B412 1137.27 Erythropoietin increases the hypoxic sensitivity
of the neural respiratory control system in newborn mice. J.
Soliz. Laval Univ., Canada.
B413 1137.28 Thiosulfate: a readily accessible source of
hydrogen sulfide in oxygen sensing. K.R. Olson, E.R. DeLeon,
Y. Gao, K. Hurley, V. Saduskas, C. Batz and G. Stoy. Indiana
Univ. Sch. of Med.-South Bend and Univ. of Notre Dame.
B414 1137.29 NAD(P)H autofluorescence induction by
compound C in rat carotid chemoreceptor cells. I. Kim, J.L.
Fite, D. Kim, D.F. Donnelly and J.L. Carroll. Univ. of Arkansas
for Med. Sci., Chicago Med. Sch. and Yale Univ. Sch. of Med.
TUESDAYPHYSIOLOGY
1138.VASCULAR PATHOBIOLOGY I
1139.VASCULAR SMOOTH MUSCLE II
Poster
Poster
Exhibit Halls A-B
Exhibit Halls A-B
B415 1138.1 Polyphenols prevent obesity-induced aortic
vascular stiffness in C57BL/6 mice. R.M. Weisbrod, J. Fry, P.
Chauhan, R.A. Cohen and F. Seta. Boston Univ. Sch. of Med.
B416 1138.2 Expression of dysfunctional connexin40 in
vascular endothelium enhances myogenic constriction and
reduces artery distensibility. D.J. Chaston, B.K. Baillie, T.H.
Grayson, R.J. Courjaret, J.M. Heisler, K.A. Lau, K. Machaca,
B.J. Nicholson, A. Ashton, K.I. Matthaei and C.E. Hill.
Australian Natl. Univ., Weill Cornell Med. Col.-Qatar, Univ. of
Texas Hlth. Sci. Ctr. at San Antonio and Univ. of Sydney.
B417 1138.3 Arterial stiffness in diet-induced obese mice
is reversed by weight loss. T. Shiang, L. Al Sayah, J. Fry, R.
Weisbrod, S. Bajpai, C. Reinhart-King, R. Cohen and F.
Seta. Boston Univ. and Cornell Univ.
B418 1138.4 Vascular
aging:
association
between
endothelial function and arterial stiffness. M. Heldens, T.
Tarumi, M. Ayaz, R. Parker, C. Tinajero, C. Hill, B.Y. Tseng,
J. Liu and R. Zhang. Radboud Univ. Nijmegen Med. Ctr.,
Netherlands, Texas Hlth. Presbyterian Hosp. Dallas and Univ.
of Texas Southwestern Med. Ctr.
B419 1138.5 Angiotensin II increases arterial stiffness that
is prevented by polyphenol S17834. J.L. Fry, R.M. Weisbrod,
F. Seta and R.A. Cohen. Boston Univ. Med. Ctr.
B420 1138.6 Toll-like receptor 4 mediates cavernosal
dysfunction in diabetic rats. K.P. Nunes, M.A. CarriloSepulveda, T. Szasz and R.C. Webb. Georgia Hlth. Sci. Univ.
B421 1138.7 Novel anti-atherogenic effects of trivalent
chromium in vascular smooth muscle cells: therapeutic
implication for diabetic vascular complications. R. Ganguly, S.
Sahu and P. Raman. Northeast Ohio Med. Univ.
B422 1138.8 Reduced NO bioavailability, oxidative stress
and alteration of calcium homeostasis in vascular endothelium
from diabetic mice. S. Banquet, M.P. Bourguignon, A. Garry,
E. Royere, C. Crespo, I. Lapret, S. Simonet, W. Gosgnach,
C. Thollon, N. Villeneuve and J.P. Vilaine. Servier Res. Inst.,
Suresnes, France.
B423 1138.9 Transcriptional mechanisms that mediate
upregulation of thrombospondin-1 expression by leptin in
vascular smooth muscle cells. S. Sahu, R. Chavez, R. Ganguly
and P. Raman. Northeast Ohio Med. Univ.
B424 1138.10 Angiopoietin like-2 knock-down improves the
lipid profile of high-fat diet-fed mice and maintains vascular
endothelial function. C. Yu and E. Thorin. Montreal Heart Inst.
and Univ. of Montreal.
POSTER PRESENTERS:
UPLOAD YOUR POSTER
Where: E-Poster Counter, Sun. – Tue. Hall A; Wed. Hall C
Deadline: Tue., April 23, 5:00 pm; Wed., April 24, 3:00 pm
Uploaded posters will be available online to all
registered attendees following the meeting at
www. experimentalbiology.org
B425 1139.1 The function of cAMP responsive element
modulator in PDGF induced proliferation of vascular smooth
muscle cells. M.D. Seidl, I. Hildebrandt, C. Klugstedt, F.
Nunes, S. Endo, N. Kojima, W. Schmitz and F.U. Müller. Univ.
of Münster, Tokyo Metro. Inst. of Gerontol. and Gunma Univ.
Med. Sch., Japan.
B426 1139.2 cGMP-dependent protein kinase I (PKGI)
undergoes post-translational modifications in the Golgi
apparatus. S. Kato and J.D. Roberts, Jr. Massachusetts Gen.
Hosp., Charlestown.
B427 1139.3 Inhibition of vascular smooth muscle growth
by the soluble guanylyl cyclase activator BAY 60-2770. D.N.
Martin, S.P. Adderley, C.N. Joshi, W. Durante and D.A. Tulis.
Brody Sch. of Med. at East Carolina Univ. and Univ. of MissouriColumbia Sch. of Med.
B428 1139.4 Cascade transmission in skeletal muscle
arteries. H.A. Kluess. Auburn Univ.
B429 1139.5 Molecular interactions of serotonin and
endothelin-1 in vascular smooth muscle cells: roles of p42/44
mitogen activated protein kinase and Janus kinase 2 pathways.
S. Bhaskaran, J. Zaluski and A.K.L. Banes-Berceli. Oakland
Univ., MI.
B430 1139.6 TNFa receptor 1 causes endocytosisdependent NF-kB and -independent JNK activation in vascular
smooth muscle cells. H. Choi and F.S. Lamb. Vanderbilt Univ.
Med. Ctr.
B431 1139.7 Hydrogen peroxide modulates the contractile
response induced by phenylephrine in renal hypertensive
rat aorta. B.R. Silva, L. Pernomian, M.D. Grando and L.M.
Bendhack. Sch. of Med. and Fac. of Pharmaceut. Sci. of
Ribeirão Preto, Univ. of São Paulo.
B432 1139.8 Reactive oxygen species and purinergic
signaling contribute to the thyroid hormone-induced
vasodilation. C.R. Fürstenau Basso, L.R.G. Bechara, A.
Belló-Klein, P.C. Brum and M.L.M. Barreto-Chaves. Sch. of
Phys. Educ. and Sport, Univ. of São Paulo and Fed. Univ. of Rio
Grande do Sul, Brazil.
B433 1139.9 The G protein-coupled estrogen receptor
1 (GPER1/GPR30) agonist G-1 regulates vascular smooth
muscle cell Ca2+ handling. A. Holm, B. Olde, F. Leeb-Lundberg
and B-O. Nilsson. Lund Univ., Sweden.
1140.LUNG PHYSIOLOGY: PULMONARY
HYPERTENSION
Poster
Exhibit Halls A-B
B434 1140.1 Inhibition of soluble epoxide hydrolase
augments hypoxic pulmonary vasoconstriction and improves
gas exchange in mice. A. Beloiartsev, C. Ventocilla, J.D.
Winkler, K.D. Bloch and W.M. Zapol. Massachusetts Gen.
Hosp. and Univ. of Pennsylvania.
397
T
U
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PHYSIOLOGYTUESDAY
B435 1140.2 Mitochondrial catalase expression protects
against hypoxia-induced pulmonary hypertension. S.E.
Adesina, C.M. Hart and R.L. Sutliff. Atlanta VA Med. Ctr. and
Emory Univ.
B436 1140.3 Pressure-dependent pulmonary arterieal tone
following chronic hypoxia requires depolarization-induced
activation of epidermal growth factor receptor and NADPH
oxidase. C.E. Norton, B.R. Walker and T.C. Resta. Univ. of
New Mexico.
B437 1140.4 Loss of endogenous H2O2-induced inhibition
of ASIC1-mediated Ca2+ influx in pulmonary artery smooth
muscle cells following chronic hypoxia. D.R. Plomaritas, L.M.
Herbert, T.C. Resta, B.R. Walker and N.L. Jernigan. Univ. of
New Mexico Hlth. Sci. Ctr.
B438 1140.5 Underdeveloped
bradykinin-dependent
vasorelaxation in immature pulmonary arteries from long term
hypoxic sheep is not due to loss of cGMP signaling. C.L. Wee,
C. Blum-Johnston, Q. Blood, R.H. Wilson, A.B. Blood, L.D.
Longo and S.M. Wilson. Loma Linda Univ.
B439 1140.6 Postnatal-related changes in cAMP mediated
pulmonary arterial relaxation and calcium signals persist
following long term hypoxia in sheep. R. Paez, M. Rubalcava,
Q. Blood, S. Hong, M. Francis, M.S. Taylor, L.D. Longo and
S.M. Wilson. Loma Linda Univ. and Univ. of South Alabama
Col. of Med.
B440 1140.7 Bradykinin-induced pulmonary vasorelaxation
is modified by long term hypoxia and postnatal maturation in
sheep. C. Blum-Johnston, Q. Blood, C. Wee, R. Wilson, A.B.
Blood, L.D. Longo and S. Wilson. Loma Linda Univ.
B441 1140.8 Implication of lysophosphatidic acid in hypoxic
pulmonary vascular remodeling: effects on cell adhesion and
migration. V. Shlyonsky, R. Naeije and F. Mies. Univ. Libre of
Brussels.
B442 1140.9 TRPC1 and TRPC6 regulate chronic
hypoxia-induced vascular tone, vasoreactivity and pulmonary
hypertension. Y. Xia, X-R. Yang, O. Paudel, Z. Fu, L.
Birnbaumer and J.S.K. Sham. Johns Hopkins Univ. and Natl.
Inst. of Envrn. Sci., Durham.
B443 1140.10 Adaptive immune cells contribute to chronic
hypoxia-induced pulmonary hypertension. L.D. Maston, T.C.
Resta, J.L. Cannon, W. Giermakowska and L.V. González
Bosc. Univ. of New Mexico.
B444 1140.11 Development and long term hypoxia: changes
in ryanodine receptor expression in ovine pulmonary arteries.
K.L. Young II, R. Goyal, Q. Blood, S.M. Wilson and L.D.
Longo. Loma Linda Univ.
B445 1140.12 Pde3a-deficient mice have evidence of
pulmonary hypertension. B. Chen, X. Meng, Y. Jin and L.D.
Nelin. Nationwide Children’s Hosp. and The Ohio State Univ.
B446 1140.13 Pulmonary vascular reactivity with aging. K.
Pugh and G. Balanos. Sch. of Sports and Exercise Sci., Univ.
of Birmingham, U.K.
B447 1140.14 Transient receptor potential channels contribute
to an enhanced endothelial cell proliferation and irreversible
vascular remodeling associated with the development of
pulmonary arterial hypertension. P. Sundivakkam, H. Tang, R.
Fernandez, A. Drennan and J.X-J. Yuan. Univ. of Illinois at
Chicago.
B448 1140.15 The C-terminal tail of aquaporin 1 is required
for migration and proliferation of pulmonary arterial smooth
muscle cells. N. Lai, J.M. Lade, K. Leggett, C. Undem, M.
Crow, X. Yun and L.A. Shimoda. Johns Hopkins Univ.
398
B449 1140.16 Can haptoglobin attenuate hemoglobininduced vascular damage? Y. Alonso, C. Lisk and D. Irwin.
Univ. of Puerto Rico at Ponce and Univ. of Colorado Denver,
Anschutz Med. Campus.
B450 1140.17 Poly ADP-ribose polymerase (PARP-1) and
DNA damage in pulmonary arterial hypertension. J. Meloche,
A. Courboulin, J. Krietsch, G. Margaillan, A. Courchesne,
Y. Coulombe, S. Provencher, G. Poirier, J-Y. Masson and S.
Bonnet. CHUQ, Laval Univ., Canada.
B451 1140.18 Inhibition of the receptor of advanced glycation
reverses pulmonary arterial hypertension. J. Meloche, A.
Courchesne, M. Barrier, M-P. Tremblay, S. Breuils-Bonnet,
E. Tremblay, S. Provencher and S. Bonnet. Laval Univ.,
Canada.
B452 1140.19 Effect of VPAC2 agonist on improving cardiac
output in pulmonary hypertension. Y. Mizuno, M. Koga, S.
Kashiwagi, I. Watanabe and T. Goto. Yokohama City Univ.
B453 1140.20 miR204/RUNX2 axis regulates HIF-1a
activation in pulmonary arterial hypertension. G. Margaillan,
M. Barrier, F. Potus, J. Meloche, A. Courboulin, C. Couture,
P. Bonnet, S. Provencher and S. Bonnet. CRIUCPQ, Quebec.
B454 1140.21 Morphological changes of the intrinsic cardiac
nervous system in experimental models of right ventricular
hypertrophy. M.J. Gómez Villalobos, R. Giles and G. Flores.
Autonomous Univ. of Puebla, Mexico.
1141.LUNG PHYSIOLOGY: VASCULAR SMOOTH
MUSCLE BIOLOGY, VASCULAR REGULATION
AND HYPOXIA
Poster
Exhibit Halls A-B
B455 1141.1 Nitric oxide bioavailability in patients with cystic
fibrosis. R.A. Harris, N. Seigler, B. Fox, C. White, L. Brantley,
D. Eidson and K.T. McKie. Georgia Hlth. Sci. Univ.
B456 1141.2 The role of the type III transforming growth
factor-b receptor TGFbr3 in the regulation of pulmonary
vascular development. G. Niess, J. Wygowski, W. Seeger and
R.E. Morty. Max Planck Inst. for Heart and Lung Res., Bad
Nauheim.
B457 1141.3 Effects of hypoxia on regulators of G-protein
signaling 2 regulation of pulmonary arterial constriction. N.
Jain, Y. Tu and P.W. Abel. Creighton Univ.
B458 1141.4 Quantification of reduced blood flow through
intrapulmonary arteriovenous anastomoses in healthy humans
during exercise breathing 100% O2. S. Laurie, J.E. Elliott,
J.W. Duke, R.D. Goodman, I.M. Gladstone, M.B. Fish and
A.T. Lovering. Johns Hopkins Med. Inst., Univ. of Oregon
and Oregon Heart & Vasc. Inst. and Sacred Heart Med. Ctr.,
Springfield, OR.
B459 1141.5 Activation of calpain in pulmonary arterial
smooth muscle cells. L. Kovacs, R. Rafikov, A. Szabo, Z.
Bagi, S.M. Black and Y. Su. Med. Col. of Georgia, Georgia
Regents Univ.
B460 1141.6 Loss of PPARg promotes NF-kB activation,
Nox4 induction, and proliferation of human pulmonary artery
smooth muscle cells. K.M. Bijli, B-Y. Kang, T. Murphy and
C.M. Hart. Atlanta VA Med. Ctr. and Emory Univ. Med. Ctr.
TUESDAYPHYSIOLOGY
B461 1141.7 Characterization of ryanodine receptor-gated
store-operated calcium entry in rat pulmonary artery smooth
muscle cells. A.H.Y. Lin, H. Sun, Y-L. Jiang, M-J. Lin and
J.S.K. Sham. Johns Hopkins Univ.
B462 1141.8 Alterations in intracellular Ca2+ release via
CD38-dependent pathways in pulmonary arterial smooth
muscle of rat by chronic hypoxia. S. Lee, Y. Jiang, O. Paudel
and J.S.K. Sham. Johns Hopkins Univ. and Johns Hopkins
Sch. of Publ. Hlth.
B463 1141.9 Thioredoxin-1 is necessary for hypoxiainduced cell proliferation in human pulmonary artery smooth
muscle cells. Y. Jin, T.E. Tipple, L.G. Chicoine, L.D. Nelin
and B. Chen. Nationwide Children’s Hosp. and The Ohio State
Univ.
1142.FREE RADICAL SIGNALING, OXIDANT STRESS
AND INJURY II
B473 1142.10 Compartmentalization of redox processes,
Nox4 and endoplasmic reticulum chaperones within lipid
droplets in vascular smooth muscle cells. T.B. Abrahao. InCor,
São Paulo.
B474 1142.11 Signaling mechanism of cytochrome P450 1B1dependent angiotensin II-induced activation of NADPH oxidase
in vascular smooth muscle cells. C.Y. Song, B.L. Jennings, J.
Lin, X.R. Fang and K.U. Malik. Univ. of Tennessee Hlth. Sci.
Ctr., Memphis.
B475 1142.12 Quantitative analysis of tetrahydrobiopterin
synthesis and oxidation in eNOS uncoupling. S. Kar and M.
Kavdia. Wayne State Univ.
B476 1142.13 Hydrogen peroxide induced changes in
endothelial function. H. Patel, J. Chen, S. Daoud and M.
Kavdia. Wayne State Univ.
1143.OXIDATIVE STRESS III
Poster
Poster
Exhibit Halls A-B
Exhibit Halls A-B
B464 1142.1 Elevated peripheral blood mononuclear cellderived superoxide production in healthy young black men.
S.H. Deo, S.W. Holwerda, D.M. Keller and P.J. Fadel. Univ. of
Missouri-Columbia and Univ. of Texas at Arlington.
B465 1142.2 Restoration of endothelial function in Ppara-/mice by Tempol. N. Silswal, M.J. Wacker and J. Andresen.
Univ. of Missouri-Kansas City.
B466 1142.3 Determination of Prdx6 binding sites for its
interaction with SP-A. S.Y. Krishnaiah, C. Dodia, S.I. Feinstein
and A.B. Fisher. Univ. of Pennsylvania Sch. of Med.
B467 1142.4 Direct and indirect effects of particulate
exposure on the heart. M.W. Gorr, D.J. Youtz, E. CormetBoyaka and L.E. Wold. Nationwide Children’s Hosp. and The
Ohio State Univ.
B468 1142.5 Effect of prenatal antioxidant sulforaphane on
fetal transcriptomics in mice. H-Y. Cho, L. Miller-DeGraff, L.
Perrow, M. Yamamoto and S.R. Kleeberger. NIEHS, NIH,
Research Triangle Park and Tohoku Univ. Grad. Sch. of Med.,
Japan.
B469 1142.6 Systemic oxidative stress in older adults: do
peripheral blood mononuclear cells contribute? J.C. Schanzle,
S.H. Deo and P.J. Fadel. Univ. of Missouri-Columbia.
B470 1142.7 PPARa
modulates
acrolein-induced
inflammatory signaling in gp91phox knock-out mice. K. Marek,
N. Chug, Z. Yousefipour and M. Newaz. Chicago State Univ.
and Texas Southern Univ.
B471 1142.8 Caveolin-1 regulates neuronal regeneration
in peripheral nerve crush injury via regulation of Schwann cell
function. S.D. Garcia, J. Dolkas, I. Shubayev, S.E. Kellerhals,
J.M. Schilling, V.I. Shubayev, H.H. Patel and Y. Kim. UCSD
and VA San Diego Healthcare Syst.
B472 1142.9 Neuroprotective properties of antioxidants
in stroke correlate with their effects on ischemic release of
glutamate. P. Dohare, A. Vipani, M.C. Hyzinski-Garcia, N.H.
Bowens, P.J. Feustel, R.W. Keller, Jr., D. Jourd’heuil and
A.A. Mongin. Albany Med. Col.
B477 1143.1 Proteomic analysis of the lung proteome after
chronic ethanol exposure. A.A. Alli, D.S. Montgomery, M.S.
Ghant, D.C. Eaton and M.N. Helms. Emory Univ. and Clark
Atlanta Univ.
B478 1143.2 EtOH consumption contributes to a ‘pro-injury’
environment in the alcoholic lung. A.F. Eaton, L.A. Brown and
M.N. Helms. Emory Univ. and Children’s Healthcare of Atlanta.
B479 1143.3 Detecting cell adhesion molecules in intact
lung using quantum dot conjugates targeted to endothelial
cells. R.L. Orndorff, N.K. Hong, B.J. Zern, K. Yu, K. Debolt,
V.R. Muzykantov, S. Huang, A.B. Fisher and S. Chatterjee.
Univ. of Pennsylvania.
B480 1143.4 Resolvins play a role in the resolution of
acute lung injury. R.R. Cox, Jr., O. Phillips, J. Fukumoto,
I. Fukumoto, P. Tamarapu Parthasarathy, V. Lagishetty,
T. Luong, N. Remsen, R. Lockey and N. Kolliputi. Univ. of
South Florida Morsani Col. of Med.
B481 1143.5 ASC plays a role in alveolar epithelial integrity. J.
Fukumoto, I. Fukumoto, O. Phillips, R. Cox, Jr., P. Tamarapu
Parthasarathy, V. Lgishetty, R. Lockey and N. Kolliputi. Univ.
of South Florida.
B482 1143.6 Caveolae regulate nitroxidative signaling via
localized nitration of Src-family kinase in endothelial cells. H.
Singh and V. Rizzo. Temple Univ. Sch. of Med.
B483 1143.7 Resveratrol blunts the positive effects of
exercise training in aged men; a double-blind, randomized,
placebo-controlled training study. L. Gliemann, M. Nyberg,
R.S. Biensø, N. Iversen, J. Olesen, S.P. Mortensen, J.F.
Schmidt, H. Pilegaard and Y. Hellsten. Univ. of Copenhagen
and Rigshospitalet.
B484 1143.8 Nitric oxide deficit elicits oxidative stress and
augments T-type calcium channel contribution to vascular tone.
C.E. Hill, I.Y. Kuo, A. Ellis, D.J. Chaston, H-S. Shin, P.B.
Hansen and L. Howitt. Australian Natl. Univ., Korea Inst. of
Sci. and Technol. and Univ. of Southern Denmark.
399
T
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PHYSIOLOGYTUESDAY
B485 1143.9 N-acetylcysteine administration modulates
NADPH oxidase in skeletal muscle of rats with heart failure.
P.F. Martinez, D.C. Fernandes, C. Bonomo, M.D.M. Cezar,
S.A. Oliveira, Jr., L.A.M. Zornoff, K. Okoshi, F.R. Laurindo
and M.P. Okoshi. UNESP, Botucatu, InCor, São Paulo and
UFMS, Campo Grande, Brazil.
B486 1143.10 Correlation between cardiovascular autonomic
control dysfunction and oxidative stress in an experimental
model of hypertensive and menopause submitted to fructose
overload. F.F. Conti, J.O. Brito, R.K. Palma, N. Bernardes, I.C.
Sanches, M.C. Irigoyen and K. De Angelis. Nove de Julho
Univ., Brazil and Univ. of São Paulo - Heart Inst.
B487 1143.11 Dependence of cytotoxicity of menadione and
cytoprotection by antioxidants in human endothelial cells on
oxygen levels: atmospheric oxygen versus physiological levels.
A. Rastogi, S. Stavchansky and P. Bowman. U.S. Army Inst.
of Surg. Res., Fort Sam Houston, The Geneva Fndn., Tacoma,
WA and Univ. of Texas at Austin.
B488 1143.12 Role of TRPC6 in high glucose-induced
podocyte apoptosis. B-C. Liu, X. Song, L-L. Yang, D. Eaton
and H-P. Ma. Emory Univ. Sch. of Med.
B489 1143.13 Superoxide and hydrogen peroxide stimulate
renin release from juxtaglomerular cells. M. Mendez. Henry
Ford Hosp..
B490 1143.14 The effect of allopurinol administration on
xanthine oxidoreductase and mitochondrial respiration in
broiler chickens. T.L. Settle, E. Falkenstein, K. Blemings and
H. Klandorf. West Virginia Univ.
B491 1143.15 Hydrogen peroxide is not increased in
angiotensin II-stimulated neurons overexpressing superoxide
dismutase. A.J. Case, R.F. Cruz and M.C. Zimmerman. Univ.
of Nebraska Med. Ctr. and Univ. of Nebraska-Lincoln.
B492 1143.16 Proteomic analysis of the cAMP/protein kinase
A (PKA) signaling pathway identifies PKA as a regulator
of cellular response to oxidative stress. T. McCann, A.S.
Wilderman, Y. Guo, S.S. Taylor and P.A. Insel. UCSD and
HHMI.
1144.OXIDATIVE STRESS BIOLOGY
Poster
Exhibit Halls A-B
B493 1144.1 Differential effects of low pH on Ca2+-induced
ROS emission from mitochondrial complexes I and III. D.P.
Lindsay, A.K.S. Camara, D.F. Stowe and M. Aldakkak. Med.
Col. of Wisconsin.
B494 1144.2 Attenuating complex I activity decreases p66shc
phosphorylation and translocation to mitochondria during
cardiac ischemia reperfusion injury. M. Yang, D.F. Stowe, J.S.
Heisner and A.K.S. Camara. Med. Col. of Wisconsin and VA
Med. Ctr.
B495 1144.3 HVCN1 contributes to superoxide production
independent of intracellular pH regulation. P.M. O’Connor, J.
Sun and B.A. Mazer. Georgia Hlth. Sci. Univ.
B496 1144.4 Loud sound-induced hearing loss is prevented
by methylene blue. T.M. Wilson, I. Omelcheko, S. Foster and
A.L. Nuttall. Oregon Hlth. & Sci. Univ.
400
B497 1144.5 Lysophosphatidic acid induces reactive oxygen
species generation through PLC/PKC/Nox pathway in PC-3
prostate cancer cells. C-C. Lin, C-E. Lin, Y-C. Lin and H. Lee.
Natl. Taiwan Univ.
B498 1144.6 Oxidative stress and ER stress induce
Zidovudine (AZT)-mediated hepatic lipid accumulation. A.
Banerjee, M.A. Abdelmegeed, S. Jang and B.J. Song.
NIAAA, NIH, Rockville.
B499 1144.7 Inspiratory
muscle
exercise
reduces
lipoperoxidation in obese and healthy subjects: a pilot study.
C.C. Callegaro, L. Maldaner, L. Donato, A. Spring, F. Porto,
L. Chaves and R. Cattaneo. Univ. of Cruz Alta, Brazil.
B500 1144.8 Ketone supplementation reduces superoxide
production in cultured primary human dermal fibroblasts:
comparison of young versus aged cells. S.L. Kesl, A.N. Moor,
M.Y. Jung, A.M. Poff, L. Gould and D.P. D’Agostino. Morsani
Col. of Med., Univ. of South Florida.
1145.ION TRANSPORT IN CELL DIFFERENTIATION,
MIGRATION, POLARIZATION AND ADHESION
(POSTERS)
Poster
Exhibit Halls A-B
B501 1145.1 Regulation of cell motility by Na+/H+ exchanger
NHE1: implications for cancer development. S.F. Pedersen.
Univ. of Copenhagen.
B502 1145.2 ERM proteins colocalize with the Na+/H+
exchanger NHE1 in MCF-7 breast cancer cell invadopodia and
affect invadopodia number. G.A.B. Roest and S.F. Pedersen.
Univ. of Copenhagen.
B503 1145.3 Stable expression of the sodium iodide
symporter in metastatic cancer cells: a novel imaging tool. K.B.
Gagnon, D. Chapman, D.M.L. Cooper, S. Caine, V. Verge and
H. Nichol. Univ. of Saskatchewan.
B504 1145.4 b-Adrenergic receptor agonists known to
stimulate b-arrestin-dependent signaling inhibit CFTR activity,
cell migration and airway epithelial restitution. E.R. Peitzman
and S.M. O’Grady. Univ. of Minnesota, St. Paul.
B505 1145.5 Chloride channel inhibition reduces tail
regeneration in the developing vertebrate Ambystoma
mexicanum. B.M. Franklin, R. Voss and J. Osborn. Univ. of
Kentucky.
B506 1145.6 Adenosine inhibits human T lymphocyte
migration via inhibition of KCa3.1 channels. A.A. Chimote, V.
Kucher, N. Boiko, P. Hajdu, Z. Kuras, Y-H. Yun, O. Szilagyi
and L. Conforti. Univ. of Cincinnati and North Carolina A&T
State Univ.
B507 1145.7 Cortactin and the actin cytoskeleton control
the lateral membrane mobility of Kv1.3 channels. G.V. Martin,
P. Hajdu, A.A. Chimote, K. Takimoto, O. Szilagyi and L.
Conforti. Univ. of Cincinnati, Nagaoka Univ. of Technol., Japan
and Univ. of Debrecen, Hungary.
B508 1145.8 The role of the Arp2/3 complex in the
cytoskeleton organization and actin-mediated sodium
reabsorption in kidney epithelial cells. D.V. Ilatovskaya, V.
Chubinskiy-Nadezhdin, L.S. Shuyskiy, T.S. Pavlov, O.
Palygin, Y.A. Negulyaev and A. Staruschenko. Med. Col. of
Wisconsin and Inst. of Cytol., RAS, St. Petersburg.
TUESDAYPHYSIOLOGY
1146.STEM CELLS AND CELL GROWTH,
DEVELOPMENT AND DIFFERENTIATION
Poster
Exhibit Halls A-B
B509 1146.1 Lysophosphatidic acid inhibits megakaryocyte
differentiation in CD34+ hematopoietic stem cells. K-H. Lin,
C-L. Yao and H. Lee. Natl. Taiwan Univ. and Yuan Ze Univ.,
Taiwan.
B510 1146.2 The role of lysophosphatidic acid in
erythropoiesis in K562 human erythroleukemia cell line. Y-H.
Ho, K-H. Lin and H. Lee. Natl. Taiwan Univ.
B511 1146.3 Osteoblast differentiation of adipose tissuederived mesenchymal stem cells (MSCs) is enhanced by bone
marrow MSC-conditioned medium. M.M. Beloti, R.F. Abuna,
F.S. de Oliveira, R.B. Kato and A.L. Rosa. Sch. of Dent. of
Ribeirão Preto - Univ. of São Paulo.
B512 1146.4 Role of MMP-2 activation in oncostatin-M
induced cardiomyocyte dedifferentiation. F. Fan, M.A.M, Ali,
B.G. Hughes and R. Schulz. Univ. of Alberta.
B513 1146.5 Characterization of cardiac progenitor cells
from adult murine skeletal muscle. C.A. Pacak, I. Alpatov, S.
Fullen, S.F. Emmer and D.B. Cowan. Boston Children’s Hosp.
and Harvard Med. Sch.
B514 1146.6 Chronic binge alcohol-induced skeletal muscle
wasting: implications for satellite cell function. L.E. Decker,
N.J. LeCapitaine, G.J. Bagby, S. Nelson and P.E. Molina.
Mandeville H.S., Mandeville, LA and LSU Hlth. Sci. Ctr., New
Orleans.
B515 1146.7 Polyamines enhance satellite cell activation
and expression of myogenic regulatory factors. K.J. Thornton,
K.C. Chapalamadugu, M.E. Doumit and G.K. Murdoch. Univ.
of Idaho and Univ. of South Florida.
B516 1146.8 Chronic a 1AAR stimulation may increase adult
neurogenesis and parvalbumin interneurons. A. Nielsen, K.
Collette, D. Perez and V. Doze. Univ. of North Dakota and
Cleveland Clin. Fndn.
B517 1146.9 Critical role of Sox9 in the differentiation of
mesenchymal stem cells to endothelial cells. D.K. Agrawal, I.
Attairu, K.P. Djossou and D. Pankajakshan. Creighton Univ.
Sch. of Med.
B518 1146.10 Genotyped adipocytes to monitor adiponectin
expression in response to environmental stressors. C. Zhang,
J.B. Alley, S.A. Samy, D. Bohman, F. Bovenzi, L. Fitzgerald,
J-M. Prot, M.L. Shuler and M. Ariza-Nieto. Cornell Univ. and
Guthrie Clin., Sayre, PA.
B519 1146.11 Osteogenic
differentiation
of
human
mesenchymal stem cells induced by nanostructures. S.Y.
Choi, P.D. Ryu, S-W. Joo and S.Y. Lee. Seoul Natl. Univ. and
Soongsil Univ., South Korea.
1147.CELL-BASED THERAPY FOR THE HEART
AND KIDNEY: FROM BENCH TO BEDSIDE
(POSTERS)
Poster
Exhibit Halls A-B
B520 1147.1 Beneficial effects of angiotensin (1-7) on
dysfunctional CD34+ endothelial progenitor cells from patients
with heart failure. S. Hazra, C.T. Cole-Jeffrey, C.J. Pepine,
M.J. Katovich, M.B. Grant and M.K. Raizada. Univ. of Florida.
B521 1147.2 Mesenchymal stem cells attenuate renal
inflammation, microvascular rarefaction and fibrosis in the
renovascular hypertension rat model. M.A. Boim, E.B.
Oliveira-Sales, E. Maquigussa, P. Semedo, L.G. Pereira,
N.O. Camara, C.T. Bergamaschi and R.R. Campos. Fed.
B522 1147.3 Impact of augmenting intracellular ATP on the
inducible release of ATP from banked erythrocytes. B.S. Kirby,
H. Zhu, D.A. Riccio and T.J. McMahon. Duke Univ. Med. Ctr.
and VA Med. Ctr.
B523 1147.4 Autonomic dysregulation and its prevention by
voluntary exercise in a mouse model of chronic widespread
pain (fibromyalgia). R. Sabharwal, L.A. Rasmussen, K.A.
Sluka and M.W. Chapleau. Univ of Iowa and VA Med. Ctr.
B524 1147.5 Renal regeneration in diabetic nephropathy.
K.J. Kelly and J. Dominguez. Indiana Univ. Med. Sch.
B525 1147.6 Dystrophin insufficiency causes a Becker
muscular dystrophy-like phenotype in swine. K. Hollinger,
C-X. Yang, J.W. Ross, G.A. Rohrer, D. Nonneman and J.T.
Selsby. Iowa State Univ. and USDA, Clay Center, NE.
B526 1147.7 Differences in the association between stress,
depression and cardiovascular disease risk factors in children
and adults. S.C. Stanley, A.C. D’Audiffret, N. Pagano, S.J.
Frisbee and J.C. Frisbee. West Virginia Univ.
1148.REGULATION OF EPITHLIAL WATER AND
ION CHANNELS, TRANSCELLULAR AND
PARACELLULAR PERMEABILITY AND
EPITHELIAL POLARITY
Poster
Exhibit Halls A-B
B527 1148.1 Role of the epithelial Na+ channels in
development of ARPKD. T.S. Pavlov, V. Levchenko, D.V.
Ilatovskaya, O. Palygin and A. Staruschenko. Med. Col. of
Wisconsin.
B528 1148.2 ENaC gating is coupled to the distance
between the a- and bENaC subunits at the base of the thumb
and wrist domains. D.M. Collier and P.M. Snyder. Univ. of Iowa
Carver Col. of Med.
B529 1148.3 Mice lacking protein kinase Ca show enhanced
membrane localization and activity of the epithelial sodium
channel in the renal cortical collecting duct. H-F. Bao, Q. Yue,
T.L. Thai, J.D. Klein, J.M. Sands and D.C. Eaton. Emory Univ.
401
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B530 1148.4 Deficiency of urokinase plasminogen activator
suppresses epithelial sodium channels in tracheal epithelial
cells. H-L. Ji, Z. Chen, X. Liang, R. Zhao and M. Zhao. Univ. of
Texas Hlth. Sci. Ctr. at Tyler.
B531 1148.5 Rab22 is involved in regulation of the epithelial
sodium channel. X. Liu, C. Bertuccio, D. Devor and M.
Butterworth. Univ. of Pittsburgh.
B532 1148.6 Acetylation modulates ENaC degradation. P.L.
Butler and P.M. Snyder. Univ. of Iowa.
B533 1148.7 Sex differences in the effects of b-estradiol on
ENaC current in cell culture. J.D. Mitzelfelt, M.M. Greenlee
and D.C. Eaton. Emory Univ.
B534 1148.8 Heterogeneous nuclear ribonucleoprotein A2/
B1 is a novel aldosterone target gene in the rat distal colon
epithelium. D. Alvarez de la Rosa, I. Hernandez-Diaz, S.
Morales, G. Hernandez, E. Salido, C.M. Canessa and T.
Giraldez. Univ. of La Laguna, Univ. Hosp. NS Candelaria,
Santa Cruz de Tenerife, Univ. Hosp. of Canarias, La Laguna,
Spain and Yale Univ. Sch. of Med.
B535 1148.9 Evaluation of the H2S gasotransmitter system
as a regulator of transepithelial sodium absorption in native
lung epithelia (Xenopus laevis). M. Althaus, A. Erb, A. Agné,
K.R. Olson, P. Glombik, W.G. Clauss and M. Fronius. Justus
Liebig Univ., Germany and Indiana Univ. Sch. of Med.-South
Bend.
B536 1148.10 Biomechanical forces differentially regulate
signaling in the cortical collecting duct. R. Carrisoza, C.K.
Else, D. Flores, H.G. Lee, F.Y. Lee, R. Rohatgi and L.M.
Satlin. Mount Sinai Sch. of Med., Columbia Univ. Col. of P&S
and James J. Peters VA Med. Ctr.
B537 1148.11 Mechanosensitive activation of ATP-sensitive
K+ channels in native pulmonary epithelium depends on
pannexin and connexin hemichannel mediated ATP release. K.
Richter, K.P. Kiefer, M. Lintges, L. Geissert, W. Clauss and
M. Fronius. Justus Liebig Univ., Giessen.
B538 1148.12 Activation of electrogenic K secretion requires
BK channels in guinea pig distal colon. D.R. Halm, J. Zhang
and S.T. Halm. Wright State Univ.
B539 1148.13 Ion transport across the murine retinal pigment
epithelium. S.S. Arnason, S.B. Skarphedinsdottir and T.
Eysteinsson. Univ. of Iceland.
B540 1148.14 Inhibition of NFkB activity in renal collecting
duct cells abolishes transepithelial voltage difference. P.
Svenningsen and B.L. Jensen. Univ. of Southern Denmark.
B541 1148.15 Evidence for the existence of calcium signaling
domains in a renal cortical collecting duct cell line. T.L. Thai,
H-F. Bao, B. Liu, H. Ma and D.C. Eaton. Emory Univ.
B542 1148.16 Deletion of claudin-7 in renal collecting duct
cells impairs paracellular chloride permeability. J. Fan, R.
Tatum, J. Hoggard, B.G. Jeansonne and Y-H. Chen. Brody
Sch. of Med., East Carolina Univ.
B543 1148.17 GPCR activation of CFTR through two
independent phosphorylation pathways. A. Billet and J.W.
Hanrahan. McGill Univ.
B544 1148.18 AQP2
poly-phosphorylation
and
water
permeability in inner medullary collecting duct. C.A. Miranda,
J.W. Lee, C.L. Chou and M.A. Knepper. NHLBI, NIH.
B545 1148.19 Mechanisms of interferon gamma-induced
suppression of aquaporin 1 in murine intestinal epithelium.
M. Dicay, N. Ronaghan, M. Peplowski, C. Carati and W.K.
MacNaughton. Univ. of Calgary, Canada and Flinders Univ.,
Australia.
402
B546 1148.20 Prostaglandin receptor EP2- and EP4mediated aquaporin-2 membrane accumulation does not
depend on cAMP. E.T.B. Olesen and R.A. Fenton. Aarhus
Univ., Denmark.
B547 1148.21 Intestinal epithelial endocytosis of commensal
bacteria is dependent on IFNg-induced terminal web myosin
phosphorylation and brush border fanning. L-L. Wu, W-T. Kuo,
W-H. Peng, K-S. Lu, Y-H. Ni and L.C-H. Yu. Natl. Taiwan Univ.
Col. of Med. and Natl. Taiwan Univ. Hosp.
B548 1148.22 Reduced transepithelial glucose movement
in metformin-treated airways correlates with inhibition of
hyperglycemia-induced bacterial growth. J.P. Garnett, E.H.
Baker, J.S. Tregoning and D.L. Baines. St George’s, Univ. of
London and Imperial Col. London.
B549 1148.23 Zebrafish as a model to analyze macromolecule
absorption in intestinal enterocytes. J.L. Cocchiaro, A. Navis,
M. Bagnat and J.F. Rawls. Univ. of North Carolina at Chapel
Hill and Duke Univ.
B550 1148.24 Paracellular urate transport in the placenta.
H. Sakurai, T. Kimura, A. Tsukada, S. Ohtsuki, I. Uehara,
S. Tanigaki, M. Iwashita and K. Ichida. Kyorin Univ. Sch. of
Med., Tokyo Metro. Ohtsuka Hosp., Kumamoto Univ. Fac Life
Sci, Kyorin Univ. Sch. of Med. and Tokyo Univ. Pharm. & Life
Sci., Japan.
1149.COMPARATIVE AND EVOLUTIONARY
PHYSIOLOGY: CARDIOVASCULAR,
RESPIRATORY, LOCOMOTION AND
METABOLISM
Poster
Exhibit Halls A-B
B551 1149.1 Transmural variation in the length-force
relationships and in vivo operating length ranges of the mantle
muscles of squid. H. Perilstein, J.T. Thompson, R.M. Shelton
and W.M. Kier. Franklin & Marshall Col., PA and Univ. of North
Carolina at Chapel Hill.
B552 1149.2 Investigating jumping of various Caelifera
grasshopper species over an altitudinal gradient in New York.
A.R. Stamatis, O.C. Townsend and S.D. Kirkton. Union Col.,
NY.
B553 1149.3 Scaling of midgut perimeter and amino acid
transporter expression in Manduca sexta larvae. C.M. Gillen,
H. Itagaki, A.J. Yeoh, A.V. Vela-Mendoza, K.P. Connell, A.G.
Sanderlin and A.J. Kerkhoff. Kenyon Col., OH.
B554 1149.4 Micro-CT measured tracheal changes in the
metathoracic femur of developing American locusts. K.L. Marti,
A.J. Rapoff and S.D. Kirkton. Union Col., NY.
B555 1149.5 Using corrosion casts to understand oxygen
delivery in the grasshopper leg. N.M. Ferrara and S.D. Kirkton.
Union Col., NY.
B556 1149.6 Temperature-dependent variation in respiratory
patterns and spiracular control in Rhodnius prolixus. E.
Heinrich and T. Bradley. Univ. of California, Irvine.
B557 1149.7 Respiration and ventilation responses to acute
hypoxic stress in the Guyana orange spotted cockroach. C.S.
Mallery, Jr. and E.M. Dzialowski. Univ. of North Texas.
TUESDAYPHYSIOLOGY
B558 1149.8 Pharmacogenetic approaches in altering
heart rate in Drosophila larvae. R.L. Cooper, Z.R. Majeed, J.
Titlow, A. Stacy, K. King, J.M. Rufer and C.D. Nichols. Univ
of Kentucky, Univ of Salahaddin Col. of Sci., Iraq and LSU Hlth.
B559 1149.9 Enhanced cardiac KATP channel activity after
acclimation to hypoxia in goldfish (Carassius auratus L.). J.P.
DeWitt, T.T. Ngo, S. Chan and J.S. Cameron. Wellesley Col.
B560 1149.10 Paradoxical anaerobism in desert pupfish. M.
Heuton, S. Steinberg, S. Hillyard and F. van Breukelen. Univ.
of Nevada Las Vegas.
B561 1149.11 Heart rate, blood pressure and baroreflex gain
in three species of anurans from different environments. K.A.
McNew and M.S. Hedrick. Univ. of North Texas.
B562 1149.12 Effects of developmental hypoxia on alligator
cardiac myocytes. H.A. Shiels, H. Moore, C. Hill, R. Elsey,
D. Warren and D. Crossley. Univ. of Manchester Univ. of
North Texas, Saint Louis Univ. and Rockefeller Refuge, Grand
Chenier, LA.
B563 1149.13 Environmentally-induced phenotypic plasticity
in embryonic reptiles. D.A. Crossley, R. Elsey, C. Marks and
J. Eme. Univ. of North Texas and Rockefeller Wildlife Refuge,
Grand Chenier, LA.
B564 1149.14 Lung volume and pulmonary compliance in the
alligator (Alligator mississippiensis). M.S. Hedrick, Z.F. Kohl,
M. Khan, J. Eme, E.M. Dzialowski and D.A. Crossley. Univ. of
North Texas.
B565 1149.15 The effects of hypoxic development on cardiac
function in fetal chickens. S.S. Jonker and D.A. Crossley II.
Oregon Hlth. & Sci. Univ. and Univ. of North Texas.
B566 1149.16 Heart rate and metabolic rate of bar-headed
geese flying in hypoxia. J.U. Meir, W. Jardine, J. York, B. Chua
and W.K. Milsom. Harvard Med. Sch. and Univ. of British
Columbia.
B567 1149.17 Development of endothermy in the Pekin duck
(Anas pekin). S. Ream, A. Duquaine, S.K. Goy Sirsat, T.S.
Sirsat and E.M. Dzialowski. Univ. of North Texas.
B568 1149.18 The small heart of the ornate tinamou is
compatible with endothermy and flight but compromises
aerobic metabolism and thermoregulation during recovery
from exhaustive activity. J. Altimiras, L.M. Giraldo Deck and
Á. Garitano-Zavala. Linköpings Univ., Sweden and Univ.
Mayor de San Andrés, Bolivia.
B569 1149.19 Influence of regular endurance training on
postexercise hemodynamic regulation to orthostatic challenge.
J. Sugawara, H. Komine, T. Miyazawa, T. Imai and S. Ogoh.
Natl. Inst. of Adv. Ind. Sci. and Technol., Tsukuba, Univ. of
Tsukuba and Toyo Univ., Japan.
B570 1149.20 Pulmonary functions in different phases of
menstrual cycle. E. Saperova and D. Dimitriev. Chuvash State
Pedagogical Univ., Russia.
B571 1149.21 The new mode to neurohumoral regulation
in respiratory and circulatory systems. X-G. Sun. Natl. Ctr. of
Cardiovasc. Dis., Beijing.
B572 1149.22 Effects of acetylcholine and cholinergic
antagonists on the activity of nucleus of the solitary tract
neurons. W.I. Furuya, E. Colombari, A.V. Ferguson and D.S.
Colombari. São Paulo State Univ., Araraquara and Queen’s
Univ., Canada.
1150.AGING AND MUSCLE FUNCTION
Poster
Exhibit Halls A-B
B573 1150.1 Motor unit number estimates in world-class
masters athletes: is 80 the new 60? M.D. Allen, G.A. Power,
M.E. Filion, T.J. Doherty, C.L. Rice, T. Taivassalo and R.T.
Hepple. Sch. of Kinesiol., Univ. of Western Ontario, Montreal
Neurol. Inst. and McGill Univ. Hlth. Ctr.
B574 1150.2 Comparative effects of high velocity and low
velocity power training on muscle performance, muscle mass
and functional ability in mobility-limited elders: a randomized
trial. K.F. Reid, K.I. Martin, G. Doros, D.J. Clark, C. Patten,
E.M. Phillips, C. Hau, W.R. Frontera and R.A. Fielding.
USDA at Tufts Univ., Boston Univ. Sch. of Publ. Hlth., Malcom
Randall VA Med. Ctr., Gainesville, FL and Vanderbilt Univ.
B575 1150.3 Effect of hypovitaminosis D on muscle function
and physical performance in Saudi women cross sectional.
K.S. Hussein. Surrey Univ., U.K. and Physiol., Jeddah, Saudi
Arabia.
B576 1150.4 Stereological analysis of Akt in muscles of
young and old rats following a single bout of stretch-shortening
contractions. E.P. Rader, J. Ensey and B.A. Baker. NIOSH,
WV.
B577 1150.5 The combined effects of anastrozole and
testosterone or trenbolone on prostate and levator anibulbocavernosus mass. D.T. Beck, J.F. Yarrow, S.C. McCoy,
L.A. Beggs, F. Ye, A. Balaez, S.M. Combs, J.R. Miller, C.F.
Conover and S.E. Borst. Malcom Randall VA Med. Ctr. and
Univ. of Florida.
B578 1150.6 Old age of male C57/BL6 mice coincides with
development of sarcopenia and anabolic resistance. M. van
Dijk, J. Nagel, F.J. Dijk, S. Walrand, K. van Norren and Y.
Luiking. Danone Res., Wageningen, Netherlands and Univ.
d’Auvergne, France.
B579 1150.7 Neural and bioenergetic mechanisms of human
skeletal muscle fatigue resistance in old age. J. Kent-Braun, A.
Tonson, J. Deblois, J. Fay, T. O’Brien, S. Foulis, G. Kamen,
D. Befroy, K. Holste and A. Christie. Univ. of Massachusetts
Amherst, Yale Univ. and Univ. of Oregon.
B580 1150.8 Sarcopenia and hypertrophy in aged skeletal
muscle is independent of lifelong muscle stem cell depletion. J.D.
Lee, J. Mula, C.S. Fry, T.J. Kirby, J.R. Jackson, J.A. Beggs,
M.S. Campbell, T.E. Kmiec, E.E. Dupont-Versteegden, J.J.
McCarthy and C.A. Peterson. Univ. of Kentucky.
B581 1150.9 Age-associated attenuation of autophagy
underlies ryanodine receptor hyperactivity. L.L. Cooper, Y.C.
Lu, J. Centracchio, R. Terentyeva, D. Terentyev and G.
Koren. Brown Univ. and Rhode Island Hosp., Alpert Med. Sch.
B582 1150.10 The influence of satellite cell-depletion on
glycosaminoglycan accumulation in aged skeletal muscle. Z.J.
Hardyniec, J.D. Lee and C.A. Peterson. Alma Col., MI and
Univ. of Kentucky.
403
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1151.MICRORNA AND STEM CELLS IN MUSCLE
PATHOPHYSIOLOGY
Poster
Exhibit Halls A-B
B583 1151.1 Mitochondrial division inhibitor ameliorates
post-myocardial infarction via stimulating stem cell by elevating
level of miR-499 in diabetes. N. Qipshidze, P.K. Mishra and
S.C. Tyagi. Univ. of Louisville.
B584 1151.2 miR-133a ameliorates cardiac stem cells
survival and differentiation in Insulin2 mutant diabetic mice.
V. Chavali, N.L. Diaz, S.C. Tyagi and P.K. Mishra. Univ. of
Louisville.
1152.SKELETAL MUSCLE PHYSIOLOGY
Poster
Exhibit Halls A-B
B585 1152.1 Effects of estrogen on statin-induced toxicity
in proliferating and differentiating myoblasts. C.C. Mertz, M.
Bielman and K.L. Ball. Alma Col., MI.
B586 1152.2 Interleukin 6 alters myogenic regulatory
factors expression in cultured mammalian satellite cells. J.A.
Macumber, K.J. Thornton, M.E. Doumit and G.K. Murdoch.
Univ. of Idaho.
B587 1152.3 MC3R activation does not attenuate proinflammatory macrophage-induced reductions in myoblast
proliferation. D.S. Kump, S. Brooks and R.A. Kump. WinstonSalem State Univ. and Hanes Magnet Sch., Winston-Salem.
B588 1152.4 Satellite cells regulate the skeletal muscle
environment by inhibiting fibroblast function. C.S. Fry, J.D.
Lee, J.R. Jackson, T.J. Kirby, E.E. Dupont-Versteegden, J.J.
McCarthy and C.A. Peterson. Univ. of Kentucky.
B589 1152.5 Monocarboxylate transporter expression at
the onset of skeletal muscle regeneration. D. Smith and T.
Washington. Univ. of Arkansas.
B590 1152.6 Hormone-sensitive lipase knockout mice have
higher post-exercise insulin sensitivity despite accumulation of
diacylglycerol. A.K. Serup, T. Alsted, J. Wojtaszewski and B.
Kiens. Univ. of Copenhagen.
B591 1152.7 Rac1 is a novel regulator of stretch-induced
glucose uptake in muscle. L. Sylow, M. Kleinert, E.A. Richter
and T.E. Jensen. Univ. of Copenhagen.
B592 1152.8 The myosin converter region influences crossbridge stiffness and muscle kinetics. D. Swank, B. Glasheen,
S. Ramanath, Q. Wang, D. Sheppard and L. Riley. Rensselaer
Polytech Inst.
B593 1152.9 Satellite cell depletion negatively impacts
voluntary wheel running performance in mice. J.R. Jackson,
C.S. Fry, T.J. Kirby, J.D. Lee, C.S. Dean, J.H. Werker, J.J.
McCarthy, E.E. Dupont-Versteegden and C.A. Peterson.
Univ. of Kentucky.
B594 1152.10 Effects of hydrogen ion and inorganic
phosphate on calcium sensitivity in rat slow muscle fibers. C.R.
Nelson and R.H. Fitts. Marquette Univ.
404
B595 1152.11 Improvements in aerobic fitness but not
mitochondrial content are intensity dependent in overweight
men. J.C. Boyd, C.A. Simpson, M.E. Jung and B.J. Gurd.
Queen’s Univ., Canada and Univ. of British Columbia at
Okanogan.
B596 1152.12 The differential accumulation of doxorubicin in
the soleus and gastrocnemius muscle of the rat. S.A. Fabris, P.
Chenard, L. Anderson and D. MacLean. Laurentian Univ. and
Northern Ontario Sch. of Med.
B597 1152.13 Cellular mechanims for the protective effects of
prior exercise on statin-associated muscle force loss in mice.
M. Godar, C. Chamney and K. Huey. Drake Univ.
B598 1152.14 The role of increased sarcolipin expression in
neonatal development and in muscle disease. M. Pant, N.C.
Bal, D.A. Delfin, J.A. Rafael-Fortney and M. Periasamy. The
Ohio State Univ.
B599 1152.15 Specific and progressive diaphragmatic
myopathy during the development of heart failure. A.J. Foster,
A. Arkell, M. Platt, J.A. Simpson and C.L. Murrant. Univ. of
Guelph, Canada.
B600 1152.16 The interactive effects of K+ and Cl- on force
generation in skeletal muscles: impact at the onset of exercise.
A.M. Higgins and J-M. Renaud. Univ. of Ottawa.
B601 1152.17 Characterization of myogenesis in C2C12
myoblasts using flow cytometry. Z. Yang, C. Mo, J. Isaacson,
S. Romero-Suarez, J. Vallejo, A. Alsousi, L. Wetmore and M.
Brotto. William Jewell Col., MO and Sch. of Pharm. and Sch.
of Nursing, Univ. of Missouri-Kansas City.
B602 1152.18 Prostaglandin E2 signaling plays an important
role in the regulation of the cell cycle progression in C2C12
myoblasts. C. Mo, J. Vallejo, J. Isaacson, Z. Yang, L. Wetmore,
T. Allen, O. Igwe and M. Brotto. Univ. of Missouri-Kansas City
and William Jewell Col., MO.
B603 1152.19 Dissociation of recovery of muscle activation
and force following a sustained maximal isometric contraction.
K.E. Houle, B.J. Kantner and W.F. Brechue. U.S. Military
Acad., West Point and Philadelphia Col. of Osteo. Med.
B604 1152.20 PKCq contributes to myotube formation by
regulating protein synthesis. J.S. Marino, T. Hinds, R.A.
Hoover, E. Ondrus, J.L. Onion, A. Dowling, T. McLoughlin,
E.R. Sanchez and J.W. Hill. Univ. of Toledo.
B605 1152.21 A gender comparison of electromyography
during repetitive arm work with and without mental stress. A.
Crenshaw, M. Fahlstrom and E. Lyskov. Univ. of Gavle and
Umeå Univ., Sweden.
B606 1152.22 Muscle-specific deletion of p38a/b MAPK
improves glucose tolerance and reduces body fat but impairs
exercise capacity. N.P. Greene, V.A. Lira, K.H. Chain, M.
Zhang, S.R. Hargett, S.R. Keller and Z. Yan. Univ. of Virginia.
B607 1152.23 Fiber type specific PGC-1a content and
its relation to capillarization and mitochondrial content. G.
Gouspillou, N. Sgarioto, B. Norris and R.T. Hepple. McGill
Univ.
B608 1152.24 A novel mechanism for UCP1-independent
thermogenesis. L. Rowland, N. Bal and M. Periasamy. The
Ohio State Univ.
B609 1152.25 Vitamin
D
modulation
of
diaphragm
muscle strength in mice. A.D. Ray, K.J. Pesonius and P.A.
Hershberger. Univ. at Buffalo and Roswell Park Cancer Inst.
B610 1152.26 Resistance training and CLA/n-3 administration
improve myofiber size and myogenic capacity in high-fat dietfed mice. S-R. Lee, E. Jo, A.V. Khamoui, B-S. Park, M.C.
Zourdos, L.B. Panton, M.J. Ormsbee and J-S. Kim. Univ. of
Memphis and Florida State Univ.
TUESDAYPHYSIOLOGY
B611 1152.27 Combined endothelial and skeletal myofiber
VEGF gene deletion leads to capillary regression in adult
mouse hind limb muscle. A.G. Sulaeman, H. Delavar, J. Fine,
P.D. Wagner and E.C. Breen. UCSD.
B612 1152.28 Abnormal
fiber
type
specification
in
dystroglycanopathy skeletal muscle. A.M. Beedle and G.A.
Melick. Univ. of Georgia.
B613 1152.29 Identification of the ATP sensitive potassium
channel isolated from mammal and avian skeletal muscle. J.
Urincho-Castro, S. Manzo-Ávalos, E. Sánchez-Duarte, X.
Trujillo, M. Huerta, A. Saavedra-Molina and R. MontoyaPérez. Univ. Michoacana de San Nicolás de Hidalgo and Univ.
de Colima, Mexico.
1153.OBESITY AND SATIETY
B625 1153.12 Adiponectin expression in liver, omental fat, and
peripheral circulation in morbidly obese patients undergoing
Roux-en-Y gastric bypass. P. Sarkaria, J. Alley , B. Andrew ,
J-M. Prot, S. Samy , L. Fitzgerald , M.L. Shuler and M. ArizaNieto. Cornell Univ., Guthrie Clin. and Guthrie Fndn. for Educ.
and Res., Sayre, PA.
B626 1153.13 Body-on-a-chip BOAC: a tool to elucidate
clinical observations that involve modulations of the “ethylation
pathway in association with the expression of adipokines. M.
Ariza-Nieto, J.B. Alley, S.A. Samy, L. Fitzgerald and M.L.
Shuler. Cornell Univ. and Guthrie Clin., Sayre, PA.
1154.PANCREATIC HORMONES, DIABETES AND
NOVEL INTERVENTIONS FOR THE TREATMENT
OF OBESITY AND DIABETES
Poster
Poster
Exhibit Halls A-B
Exhibit Halls A-B
B614 1153.1 The effect of shifting food-intake period on rat
body weight and plasma levels of glucose, leptin, melatonin,
cholesterol and triglyceride. M.O. Tanira, A. Al Qutiti and B. Al
Jahwari. Sultan Qaboos Univ., Oman.
B615 1153.2 Unique roles for 3 specific amino acids in the
control of food intake. J. Jordi, T.A. Lutz and F. Verrey. Univ. of
Zurich.
B616 1153.3 Dietary sodium suppresses high-fat diet weight
gain in C57BL/6J mice. N.A. Pearson, N.K. Littlejohn, M.L.
Lutter and J.L. Grobe. Univ. of Iowa.
B617 1153.4 Impaired skeletal muscle metabolism in
obesity-prone rats on a high fat diet. T.D. Allerton, E. Bench
and S. Primeaux. LSU Hlth. Sci. Ctr., New Orleans.
B618 1153.5 Obesity-resistant rats demonstrate enhanced
energy sensing and metabolism. T.D. Allerton and S.D.
Primeaux. LSU Hlth. Sci. Ctr., New Orleans.
B619 1153.6 Cardiovascular and metabolic regulation in
mice with neuron specific deletion of the leptin receptor. J.M.
do Carmo, A.A. da Silva, B.R. Pace, M.T. Davis and J.E. Hall.
B620 1153.7 The relationship of muscle sympathetic nerve
activity to the sympathetically-mediated thermic effect of food
in young healthy subjects. L.J. Matzek, J. Miles, M. Jensen, J.
Levine, M. Joyner and T. Curry. Mayo Clin.
B621 1153.8 Low salt intake is associated with maternal
obesity before and during pregnancy. M.S. Tresoldi, J.C.
Heimann and K.L. Lopes. Univ. of São Paulo Sch. of Med.
B622 1153.9 Total circulating levels of adiponectin versus
transcript abundance in omental fat following the MIQE
guidelines in a group of morbidly obese patients. A.Z. Mobula,
J. Alley, S. Samy, L. Fitzgerald and M. Ariza. Cornell Univ.
and Guthrie Clin., Sayre, PA.
B623 1153.10 Severe left ventricular dysfunction following
short-term high fat feeding in a canine model. M. Nelson, J.
Broussard, C. Kolka, I.A. Bediako, L.S. Szczepaniak and R.
Bergman. Cedars-Sinai Med. Ctr.
B624 1153.11 Metabolic effects of polydextrose, lactitol and
Bacteroides thetaiotaomicron in rats fed with high-fat diet. K-H.
Herzig, K. Olli, M. Madetoja and K. Tiihonen. Univ. of Oulu,
DuPont Nutr. and Hlth., Kantvik and SBW/Toxis, Turku, Finland.
B627 1154.1 Pancreatic ACE2 shedding is associated with
impaired glycemia in high fat diet-fed mice. K.H. Chhabra,
K.B. Pedersen, H. Xia, V. Shenoy, M.K. Raizada and E.
Lazartigues. LSU Hlth. Sci. Ctr., New Orleans and Univ. of
Florida.
B628 1154.2 Improved satiety effect of leptin fusion proteins
with prolonged plasma half-life in mice. F. Bolze, V. Morath,
S. Schneider, S. Mocek, M. Schlapschy, A. Skerra and M.
Klingenspor. Tech Univ. Munich, Freising.
B629 1154.3 Effects of Sertoli cells implantation on type 2
diabetes in nonhuman primates. B.C. Hansen, D. Cameron,
R. Calafiore, G. Luca, E.H. Linden and C. Szekeres. Univ. of
South Florida and Univ. of Perugia.
B630 1154.4 Chronic carbon monoxide treatment attenuates
the development of obesity and remodels adipocytes in mice
fed a high fat diet. P.A. Hosick, A.A. Al Amoudi, M.V. Storm,
M.U. Gousset, B.E. Pruett, W. Gray III, J. Stout and D.E. Stec.
B631 1154.5 The role of skeletal muscle tribbles 3 on
endoplasmic reticulum stress- and high fat diet-induced insulin
resistance. H-J. Koh, T. Toyoda, M.M. Jung, M-Y. Lee, M.F.
Hirshman and L.J. Goodyear. Joslin Diabetes Ctr. Inc.
B632 1154.6 Targeting diabetes with a novel small molecule
activator of sarco/endoplasmic reticulum Ca2+-ATPase. S.
Kang, R. Dhal, K. Zsebo, D. Thomas, R. Cornea, R. Hajjar
and D. Lebeche. Mount Sinai Sch. of Med., Rosalind Franklin
Univ. of Med. and Sci., Celladon Corp., San Diego and Univ. of
Minnesota, Minneapolis.
B633 1154.7 ACE2 gene therapy decreases fibrosis in
the pancreas of high fat diet-fed mice. H. Chodavarapu, K.
Chhabra, V. Shenoy, M.K. Raizada, X.Yue and E. Lazartigues.
LSU Hlth. Sci. Ctr., New Orleans and Univ. of Florida.
B634 1154.8 Influence of fish oil on skeletal muscle
mitochondrial energetics and lipid metabolites during high-fat
diet. I.R. Lanza, A. Blachnio-Zabielska, P. Zabielski, K.S.
Nair, M. Jensen and N. Lebrasseur. Mayo Clin.
B635 1154.9 Angiogenesis inhibitor, Sunitinib significantly
reduces adipose tissue mass in high fat diet-induced
postmenopausal obese mice. J-W. Gu, K.L. Makey, E.
Chinchar, C. Howie and L. Miele. Univ. of Mississippi Med.
Ctr.
405
T
U
E
PHYSIOLOGYTUESDAY
B636 1154.10 Hypothalamic mTOR pathway mediates
neuronal actions of insulin. K. Muta, D.A. Morgan and K.
Rahmouni. Univ. of Iowa.
B637 1154.11 Transcytosis of insulin across microvascular
endothelium. P.M. Azizi, C. Wang, S.M. Armstrong, A. Klip
and W.L. Lee. Univ. of Toronto, The Hosp. for Sick Children and
St. Michael’s Hosp., Toronto.
B638 1154.12 Treatment
with
sulodexide
restores
compromised glucose tolerance in diet-induced obese mice.
B. Eskens, H. Vink and J. VanTeeffelen. Maastricht Univ.,
Netherlands.
B639 1154.13 TRPV1 in the paraventricular nucleus of the
hypothalamus is involved in the regulation of systemic blood
glucose levels. A. Zsombok, K. Miyata, J.D. O’Hare, T.L.
Fourrier, A.M. Krantz and A.V. Derbenev. Tulane Univ.
B640 1154.14 TNFa–mediated hyperglycemia in obese
Zucker rats following orthopedic trauma. L. Xiang, P.N.
Mittwede, J.S. Clemmer, S. Lu and R.L. Hester. Univ. of
B641 1154.15 Hepatocyte nuclear factor 1a stimulates the
compensatory axis of the renin-angiotensin system in the
pancreatic islet by specific induction of angiotensin-converting
enzyme 2. K.B. Pedersen, K. Chhabra and E. Lazartigues.
LSU Hlth. Sci. Ctr., New Orleans.
B642 1154.16 Activation of CaMKKa stimulates skeletal
muscle glucose uptake in insulin-resistant mice. C.A. Witczak,
J.M. Hinkley, J.L. Ferey, C.A.S. Smith, L.A.A. Gilliam and
J.J. Brault. East Carolina Univ. Brody Sch. of Med.
B643 1154.17 CaMKKa stimulates skeletal muscle glucose
uptake independent of increases in glucose transporter
expression. J.M. Hinkley and C.A. Witczak. East Carolina
Univ. Brody Sch. of Med.
B644 1154.18 Multivalent GLP-1/Yhb for targeted therapy
and imaging of pancreatic b-cells. K. Ananthakrishnan, L.V.
Penrod, N.J. Hart, C.S. Weber, M. Anderson, J. Vagner, S.W.
Limesand and R.M. Lynch. Univ. of Arizona.
B645 1154.19 Effects of the Momordica charantia in the
alterations caused by administration of a high fat diet (HL) as
a model of non-alcoholic fatty liver disease. M.E.S.M. Santos,
B.S.O. Lemos, K.B. Teixeira, L.N. Silva, G.A. Souza, F.C.H.
Pinto, L.A.R. Lima and M.E.S.M. Santos. Fed. Univ. of São
João Del Rei, Brazil.
B646 1154.20 Effect of prolonged, mild cold exposure
on metabolic regulation in insulin resistant overweight and
obese men. M. Chondronikola, N.M. Hurren, G. Porter, P.
Annamalai, E. Volpi, E. Borsheim and L. Sidossis. Univ. of
Texas Med. Branch and Shriners Hosps. for Children.
B647 1154.21 Type II diabetes increases myocardial
mitochondrial DNA damage by altered mitochondrial
topoisomerase function. J.G. Edwards, B. Piteo, D. Laurent,
M. Mitry and S. Hicks. New York Med. Col.
B648 1154.22 Upregulation of p21 activates the intrinsic
apoptotic pathway in pancreatic b cells. A.M. Hernandez, E.S.
Colvin and P.T. Fueger. Indiana Univ. Sch. of Med.
B649 1154.23 Identifying novel plasma biomarkers of
pancreatic beta-cell function using acute and chronic models
of hyperglycemia. T.P.J. Solomon, K. Karstoft, S.H. Knudsen
and B.K. Pedersen. Rigshospitalet, Copenhagen.
B650 1154.24 Rapamycin induces diabetes mellitus only in
male mice. U. Partap and S.J. Swoap. Williams Col.
B651 1154.25 Chronic rapamycin treatment confers partially
reversible diabetes mellitus. C.E. Schindler and S.J. Swoap.
Williams Col.
406
B652 1154.26 Diosgenin
administration
improved
hyperglycemia through the activation of muscular glucose
metabolism. K. Sato, S. Fujita and M. Iemitsu. Ritsumeikan
Univ., Japan.
1155.ALCOHOLIC AND NONALCOHOLIC FATTY
LIVER DISEASES
Poster
Exhibit Halls A-B
B653 1155.1 Steatosis response to curcumin in an obese
mouse model. A. Nookala, T. Quinn, B. Herndon, A. Molteni,
L. Alba, J. Nachnani and D. Bulchandani. Univ. of MissouriKansas City Sch. of Med. and Sumner Med. Gp., Gallatin, TN.
B654 1155.2 Metformin, aerobic exercise, and the
combination in the treatment of type 2 diabetes and NAFLD
in OLETF rats. M.A. Linden, G.M. Meers, J.A. Fletcher,
S. Siddique, M.H. Laughlin, F.W. Booth, J.A. Ibdah, J.P.
Thyfault and R.S. Rector. Univ. of Missouri-Columbia and
Harry S. Truman Mem. Veterans Med. Ctr.
B655 1155.3 Effects of high dose of methionine on plasma
oxidative stress and lipid profiles in rats treated with ethanol.
SY. Kim and H. Min. Hannam Univ., South Korea.
B656 1155.4 The role of b1 adrenergic receptor in nonalcoholic fat liver disease development. G.W. Fernandes, C.P.
Marcelino, P.C. Brum, M. Passarelli, B.M.L. Bocco and M.O.
Ribeiro. Fed. Univ. of São Paulo, Presbyterian Univ. Mackenzie,
São Paulo and Sch. of Phys. Educ. and Sport and Fac. of Med.
Sci., Univ. of São Paulo.
B657 1155.5 Protective effect ofHhedyotis diffusa on
lipopolysaccharide-induced liver damage. M-J. Kang and J-I.
Kim. Changwon Natl. Univ. and Inje Univ., South Korea.
1156.GASTROINTESTINAL CANCER AND
METASTASIS
Poster
Exhibit Halls A-B
B658 1156.1 Protective role of selenium and adiponectin
deficiency in chronic inflammation induced colon cancer. A.
Saxena, K. Kaur, E. Fletcher, B. Larsen, S. Hegde and R.
Fayad. Univ. of South Carolina.
B659 1156.2 New
experimental
model
of
gastric
carcinogenesis in rats with the use of formaldehyde and
hydrogen peroxide mixture. M. Senchukova, A.A. Stadnikov
and D.A. Bokov. Orenburg State Med. Acad., Russia.
B660 1156.3 The appearance of the gastric submucosal
microvessels and the degree of gastric mucosal atrophy may
predict prognosis in gastric cancer patients. O. Tomchuk.
Orenburg State Med. Acad., Russia.
B661 1156.4 Chronic gastric inflammation drives the
malignant transformation of bone marrow-derived mesenchymal
stem cells. J. Donnelly, M. Engevik, C. Xiao, R.T. Worrell and
Y. Zavros. Univ. of Cincinnati and Cincinnati Children’s Hosp.
Med. Ctr.
TUESDAYPHYSIOLOGY
B662 1156.5 Effect of leptin on HCT-116 colon cancer cell
growth. S. Tanner and D.L. Osborne. Paul Foster Sch. of
Med., Texas Tech Univ. Hlth Sci. Ctr., El Paso.
1157.GASTROINTESTINAL MOTILITY
Poster
Exhibit Halls A-B
B663 1157.1 Resveratrol relaxes cholecystokinin- and KClinduced tension in guinea pig gallbladder strips by inhibiting
extracellular Ca2+ entry. L.W. Kline and E. Karpinski. Univ. of
Alberta.
B664 1157.2 Do incisor and molar periodontal ligament
mechanoreceptors stimulate antral motility to different
degrees? M. Lorber. Georgetown Univ. Sch. of Med.
B665 1157.3 Effects of fibrates on duodenal contractions.
J.D. Peuler, D. Belisle and L.E. Phelps. Midwestern Univ., IK.
B666 1157.4 Brain-derived neurotrophic factor augments
the contraction of intestinal longitudinal muscle strips induced
by carbachol. M. Alqudah, S. Mahavadi, K.M. Srinivasa and
J. Grider. Virginia Commonwealth Univ.
B667 1157.5 Inhibitory neuromuscular transmission in the
mouse distal colon is mediated by SK and calcium activated
chloride channels. Y. Bhattarai and J. Galligan. Michigan
State Univ.
B668 1157.6 Dopamine enhances gastric motility through
D1 dopaminergic receptors on cholinergic neurons in the
myenteric plexus of rats. J. Song, L. Zheng, J. Xu and J. Zhu.
Capital Med. Univ., Beijing.
B669 1157.7 Detection of local serotonin release and
clearance in the human small intestine using amperometry. M.
France, J. Galligan and G. Swain. Michigan State Univ.
B670 1157.8 Evidence for swallowing reflexes evoked by
acid and mechanical stimulation of the vagal afferent nerves
innervating the larynx in anesthetized guinea pigs. T. Tsujimura
and B.J. Canning. Johns Hopkins Asthma and Allergy Ctr.
B671 1157.9 Perinatal high fat diet dysregulates GABAergic
signaling to vagal efferent motoneurons regulating gastric
motility. Z.K. Reagan and K.N. Browning. Penn State Col. of
Med.
B672 1157.10 Activation of both phasic and tonic GABAA
receptors modulates vagal efferent outflow regulating gastric
motor functions. Z.K. Reagan and K.N. Browning. Penn State
Col. of Med.
B673 1157.11 A Cav1.2 Ca2+ channel mutation that reduces
intestinal smooth muscle contractility. M.E. Duffey, J.M.
Helman, S.F. Gugino, J.A. Russell, G.C.L. Bett and R.L.
Rasmusson. Univ. at Buffalo.
1158.GASTROINTESTINAL NUTRIENT SENSORS
Poster
Exhibit Halls A-B
B674 1158.1 Presence of luminal acetate sensing and
absorption mechanisms in rat duodenum. I. Kaji, Y. Akiba and
J.D. Kaunitz. UCLA Med. Sch., West Los Angeles VA Med. Ctr.
and Brentwood Biomed. Res. Inst., Los Angeles.
B675 1158.2 Activation of gut calcium-sensing receptor by
peptide agonists promotes glucose tolerance in rats. T. Hira, M.
Muramatsu, A. Mitsunaga, E. Sato, S. Nakajima, Y. Kitahara,
Y. Eto and H. Hara. Sch. of Agr., Hokkaido Univ. and Ajinomoto
Co. Inc., Kawasaki.
B676 1158.3 High fat diet decreases glucose-dependent
modulation of 5-HT responses in gastrointestinal vagal afferent
neurons. A.E. Troy and K.N. Browning. Penn State Col. of
Med.
1159.GI AND LIVER STEM CELLS
Poster
Exhibit Halls A-B
B677 1159.1 Disruption of Shp2 tyrosine phosphatase
promotes Hes1/Stat3 complex in intestinal epithelia,
contributing to enhanced self-renewal capacity and impaired
differentiation in the crypt niche. Q. Gui, X. Zhang, L. Xu, H.
Cheng and Y. Ke. Sch. of Med., Hangzhou, China.
1160.GI HORMONES, PEPTIDES AND RECEPTORS
Poster
Exhibit Halls A-B
B678 1160.1 Effects of different sweeteners on incretin
hormone secretion, gastric emptying, intragastric distribution
and postprandial glycemia in healthy humans. R.M. Pereira,
M. Secaf and R.B. de Oliveira. Sch. of Med. of Ribeirão Preto,
B679 1160.2 Regulation of glucose metabolism by
nesfatin-1. Z. Li, Y. Li and W. Zhang. Peking Univ. Hlth. Sci. Ctr.
B680 1160.3 CCK8 enhances anti-diabetic efficacy of
GLP1. Y. Chen, M. Song, F. Liu, J. Lockwood, J. Alsina and
C. Hammond. Eli Lilly and Co.
B681 1160.4 Primary cilia regulate gastrin secretion in
GLUTag cells. M. Saqui-Salces and J.L. Merchant. Univ. of
Michigan.
B682 1160.5 Role of Na-K-2Cl symporter in GABA-evoked
excitation in rat enteric neurons. S. Liu, T. Ji, W. Ren, M-H.
Qu, J-X. Zhu and J.D. Wood. Univ. of Wisconsin-La Crosse,
Capital Med. Univ., Beijing and The Ohio State Univ.
407
T
U
E
PHYSIOLOGYTUESDAY
B683 1160.6 Preserved adiposity in the Fischer 344 rat
devoid of gut microbiota. F.A. Duca, T.D. Swartz, Y. Sakar and
M. Covasa. INRA, UMR 1319 Micalis, Jouy-en-Josas, France
and Col. of Osteo. Med., Western Univ. of Hlth. Sci.
B684 1160.7 Ghrelin and peptide YY increase with weight
loss during a 12-month intervention to reduce dietary energy
density in obese women. B.R. Hill, B.J. Rolls, L.S. Roe, M.J.
De Souza and N.I. Williams. Penn State.
B685 1160.8 GLP-2 receptor is required for glucose
homeostasis and energy balance. X. Shi, S. Wen, B. Chang, L.
Chan and X. Guan. Baylor Col. of Med.
1161.LIVER PHYSIOLOGY AND PATHOPHYSIOLOGY
Poster
Exhibit Halls A-B
B686 1161.1 Increased corticosterone levels contribute
to glucose intolerance induced by the absence of melatonin.
S.C. Rodrigues, L. Pantaleão, C. Lellis-Santos, K. Veras, F.
Amaral, G. Anhê and S. Bordin. Univ. of São Paulo and Fac.
of Med. Sci., State Univ. of Campinas, Brazil.
B687 1161.2 Alleviative effect of andrographolide on alphanaphthylisothiocyanate-induced cholestatic liver injury in rats.
T. Khamphaya, P. Piyachaturawat and J. Weerachayaphorn.
Mahidol Univ. Fac. of Sci., Thailand.
B688 1161.3 Enhanced autophagic flux contributes collagen
production in hepatic stellate cells involving TGFbeta1/Smad
pathway signaling. X-Z. Chen, W-M. Yao, G. Zhang, H-L. Ye,
L. Chen and F-C. Zhang. People’s Hosp. of Guangxi Zhuang
Autonomous Reg., China.
B689 1161.4 Histidine decarboxylase regulates biliary
homeostasis via autocrine histamine signaling. H. Francis, L.
Hargrove, G. Alpini and F. Meng. Scott & White Healthcare,
Central Texas Veterans Healthcare Syst. and Texas A&M Univ.
Hlth. Sci. Ctr. Col. of Med., Temple.
B690 1161.5 Genome-wide combinatorial transcriptional
regulatory dynamics during early onset of liver regeneration
and chronic alcohol intake. B. Patra, L. Kuttippurathu, D.
Cook, J.B. Hoek and R. Vadigepalli. Thomas Jefferson Univ.
B691 1161.6 Hepatic steatosis and severe coagulopathy
precede premature death in GCN2 null mice treated with
asparaginase. G.J. Wilson, P. She, E.T. Mirek, R.C. Wek and
T.G. Anthony. Rutgers Univ. and Indiana Univ. Sch. of Med.
B692 1161.7 Cystathione-g-lyase
deficiency
protects
mice from galactosamine/LPS-induced acute liver failure. K.
Shirozu, K. Tokuda, E. Marutani, D. Lefer, R. Wang and F.
Ichinose. Massachusetts Gen. Hosp. and Harvard Med. Sch.,
Charlestown, Emory Univ. Sch. of Med. and Lakehead Univ.,
Canada.
B693 1161.8 Roux-en-Y gastric bypass surgery prevents
diet-induced hepatic steatosis and endoplasmic reticulum
stress in the liver of obese rats. J.D. Mosinski, M. Pagadala,
H. Huang, O. Dan, H. Shimizu, E. Batayyah, P.R. Schauer,
S.A. Brethauer and J.P. Kirwan. Cleveland Clin. Fndn.
B694 1161.9 Characterization of the hepatic stellate cell
populations in carbon tetrachloride liver rat through Golgi-Cox
method. M.J. Gómez Villalobos, R. Giles, I. Carreon, S. Vidrio
and V. Chagoya De Sanchez. Autonomous Univ. of Puebla,
Mexico and UNAM, Mexico City.
408
1162.MECHANISMS OF INTESTINAL NUTRIENT,
WATER AND ELECTROLYTE TRANSPORT
Poster
Exhibit Halls A-B
B695 1162.1 Roles of RSK1 in LPA5R-induced NHE3
regulation. B.K. Yoo and C.C. Yun. Emory Univ.
B696 1162.2 Intact colonic K+ secretion in KCNMB2 knockout
mice. C.K. Larsen, H.A. Praetorius and J. Leipziger. Aarhus
Univ., Denmark.
B697 1162.3 GIP regulates Pept1 via Akt and EPAC signaling
pathways in intestinal epithelial cells. S. Coon, J. Schwartz
and S. Singh. Boston Univ. and VA Boston Healthcare Syst.
B698 1162.4 Luminal
acid-associated
post-prandial
epithelial hypoxia maintains the expression of iron absorptive
DMT1 and Dcytb in rat duodenum. Y. Akiba, I. Kaji and J.D.
Kaunitz. UCLA Med. Sch., West Los Angeles VA Med. Ctr. and
Brentwood Biomed. Res. Inst., Los Angeles.
B699 1162.5 Role of GLUT5 and ketohexokinase in fructoseinduced, acute increases in intestinal active Ca transport. P.
Tharabenjasin, V. Douard, N. Krishnamra, J. Zuo, R.J.
Johnson and R.P. Ferraris. UMDNJ-New Jersey Med. Sch.
and Mahidol Univ., Thailand.
B700 1162.6 Role of metabolism in fructose-induced GLUT5
regulation. C.R. Patel, V.R. Douard and R. Ferraris. UMDNJ,
Newark.
B701 1162.7 Mechanisms
underlying
modulation
of
SLC26A3 activity by Lactobacillus acidophilus-secreted
soluble factors. A. Borthakur, S. Priyamvada, A. Kumar, T.
Gujral, A.A. Natarajan, W.A. Alrefai and P.K. Dudeja. Univ. of
Illinois at Chicago and Jesse Brown VA Med. Ctr.
B702 1162.8 Farnesoid X receptor activation inhibits colonic
epithelial CFTR expression—a new target for antidiarrheal
therapy? M.S. Mroz, N. Keating, J.B.J. Ward, S. Amu, R.
Sarker, P.G. Fallon, M. Donowitz and S.J. Keely. Royal Col.
of Surgeons in Ireland, Trinity Col. Dublin and Johns Hopkins
Univ. Sch. of Med.
B703 1162.9 Leucine and methionine share a Na/Kdependent amino acid transporter in shrimp hepatopancreas.
A. Duka and G.A. Ahearn. Univ. of North Florida.
B704 1162.10 The G protein-coupled bile acid receptor,
TGR5, is expressed on colonic epithelial cells and regulates
ion transport. J.B.J. Ward, M.S. Mróz and S.J. Keely. Royal
Col. of Surgeons in Ireland.
B705 1162.11 Regulation of human intestinal SLC26A3
expression by hepatocyte nuclear factors. A. Kumar, A.
Alakkam, A. Borthakur, A.N. Anbazhagan, S. Saksena,
R.K. Gill, J. Malakooti, W.A. Alrefai and P.K. Dudeja. Univ. of
Illinois at Chicago and Jesse Brown VA Med. Ctr.
TUESDAYPHYSIOLOGY
1163.MEMBRANE TRAFFICKING AND SECRETION IN
DIGESTIVE EPITHELIA
Poster
Exhibit Halls A-B
B706 1163.1 Short duodenal acid exposure elicits protective
HCO3- secretary response via Slc26a3, Slc26a9 and CFTR
activation and NHE3 inhibition. U.E. Seidler, A.K. Singh, Y. Liu,
B. Riederer, R. Engelhardt, B.K. Thakur and M. Soleimani.
Hannover Med. Sch., Germany and Cincinnati Med. Sch.
B707 1163.2 Involvement of store-operated cAMP signaling
in the regulation of colonic secretory function. J.M. Nichols, I.
Maiellaro, J. Abi-Jaoude, S. Curci and A.M. Hofer. VA Boston
Healthcare Syst./Harvard Med. Sch., West Roxbury.
1164.NEUROTRANSMISSION AND CA2+
SENSITIZATION IN GASTROINTESTINAL
SMOOTH MUSCLES
Poster
Exhibit Halls A-B
B708 1164.1 NANC neuron mediated relaxation of murine
gastric fundus smooth muscle: phosphorylation of MYPT1 on
T696 (ROK site) and S695 (PKG site) are mutually exclusive.
G. Pfitzer, M.S. Hunger, S. Puetz, D. Metzler, L.T. Lubomirov
and A.V. Somlyo. Univ. of Cologne, Germany and Univ. of
Virginia.
B709 1164.2 Inhibition of RhoA/Rho kinase pathway and
contraction by endogenous and exogenous hydrogen sulfide
in gastrointestinal smooth muscle. A.D. Nalli, S. Rajagopal,
S. Mahavadi, J.R. Grider and K.S. Murthy. Virginia
Commonwealth Univ.
B710 1164.3 Pharmacologically-induced
alterations
in
gastrointestinal motility affects regional colonic microbial
assemblage. K. Touw, Y. Wang, E. Huang, V. Leone and E.
Chang. Univ. of Chicago.
1165.RENIN-ANGIOTENSIN SYSTEM
Poster
Exhibit Halls A-B
B711 1165.1 The dissociation of the soluble prorenin
receptor in plasma and urine of diabetic patients. D.Y. Arita, C.
Luffman, C.R.T. Bourgeois, T. Theti and M.C. Prieto. Tulane
Univ. and Fed. Univ. of Sao Paulo.
B712 1165.2 Effects of a (pro)renin receptor blocker on
weight gain in obese mice. P. Tan, Z. Shamansurova, C.
Michel, T. Nguyen, P. Schiller, J. Gutkowska and J. Lavoie.
Univ. of Montreal, CRCHUM and IRCM.
B713 1165.3 Dexamethasone differentially modulates the
human angiotensinogen gene (hAGT) expression and blood
pressure in transgenic mice containing -6A and -6G haplotype
of the hAGT gene. V.G. Pandey, S. Jain and A. Kumar. Univ.
of Toledo.
B714 1165.4 Changes in angiotensin II-induced vasomotor
function from newborn to senescence: correlation with
expression of AT1 and AT2 receptors. Z. Vamos, P. Cseplo,
Z. Bátai, O. Torok, I. Ivic, R. Matics, J. Hamar and A. Koller.
Univ. of Pecs, Hungary.
B715 1165.5 ACE2 activation ameliorates endothelial
function in the right ventricles of pulmonary hypertensive rats.
G.H. Sapp, J. Abbatematteo, C. Cole, V. Shenoy, M. Katovich,
M. Raizada and J. Muller-Delp. Univ. of Florida.
B716 1165.6 Increased ACE expression and iNOS protein
levels in the aorta of 2-month-old Syrian cardiomyopathic
hamsters. N. Cruz, J. Quidgley, L. El Musa, J. Garcia, G.
Torres, J. Miranda and M.J. Crespo. Univ. of Puerto Rico Sch.
of Med.
B717 1165.7 Effects of chronic swim stress on endocrine
and cardiac function in angiotensin AT1a receptor knockout
mice. N.K. Almahroug, A. Alhajoj, M. Alghamri, M. Morris
and R.L. Pohlman. Wright State Univ.
B718 1165.8 Angiotensin II receptors modulate nitric oxide
effects on renal sodium handling in conscious lambs. A.E.
Vinturache and F.G. Smith. Univ. of Calgary, Canada.
B719 1165.9 Ang-(1-7) induced MAS1 receptor-mediated
angiogenesis in the rat microvasculature. B.R. Hoffmann,
T.J. Stodola, J.R. Wagner and A.S. Greene. Med. Col. of
Wisconsin.
B720 1165.10 Transgenic mice containing two haplotypes
of human angiotensin receptor type 1 show differential gene
expression and regulation of blood pressure. S. Jain, V.G.
Pandey and A. Kumar. Univ. of Toledo.
B721 1165.11 Production of angiotensin within the SFO is
sufficient to increase ERK1/2 and CREB activity in the SFO
and PVN. J. Coble, J. Grobe, M. Cassell and C.D. Sigmund.
Univ. of Iowa.
B722 1165.12 Renin gene expression is regulated by
chicken ovalbumin upstream promoter transcription factor
II. P. Lachmann, S. Mayer, M. Roeser, S. Ishii, J.M. Suh, S.
Harlander, M. Desch, C. Brunssen, H. Morawietz, S.Y. Tsai,
M-J. Tsai, B. Hohenstein, C. Hugo and V.T. Todorov. Univ. of
Technol. Dresden, Univ. of Regensburg, Germany and Baylor
Col. of Med.
B723 1165.13 Human prorenin induces Ang II-independent
pressor response in neuron-specific human (pro)renin receptor
transgenic mice. H. Peng, W. Li, C.D. Sigmund and Y. Feng.
Tulane Univ. and Univ. of Iowa.
B724 1165.14 Anti-hypertensive effect of chronic ICV
angiotensin-(1-7) in (mRen2)27 transgenic rats is blocked by
Mas antagonist. L.M. Kangussu, R.A.S. Santos and M.J.
Campagnole-Santos. Fed. Univ. of Minas Gerais, Brazil.
B725 1165.15 Mineralocorticoid receptor antagonism exhibits
comparable BP lowering efficacy in Dahl salt-sensitive rats with
high versus low renin and aldosterone tone. X. Ma, L. Contino,
O. Price, D. Shuster, L. Xu, J. Xue and J. Metzger. Merck Res.
Lab., Rahway. NJ.
B726 1165.16 Angiotensin II stimulates renin synthesis and
secretion in mouse collecting duct M-1 cells via a PKC alphamediated cAMP stimulation mechanism. L. Liu, L.S. Lara, A.A.
Gonzalez, C.R.T. Bourgeois, D.M. Seth and M.C. Prieto.
Tulane Univ. Sch. of Med. and Fed. Univ. of Rio de Janeiro.
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B727 1165.17 Loss of cilia increases angiotensin II mediated
apical angiotensin-1-receptor localization in collecting duct
cells. T. Saigusa, Y. Dang, T.A. Morinelli and P.D. Bell. Med.
Univ. of South Carolina and VA Med. Ctr.
B728 1165.18 Discovery of new renal ang II processing
enzyme activity using mass spectrometry and gene deletion
mouse models. N. Grobe, K.M. Elased, E.S.B. Salem, S.B.
Gurley, F.S. Ong, K.E. Bernstein, A.H. Schmaier and M.
Morris. Wright State Univ., Duke Univ. and Durham VA Med.
Ctrs., Cedars-Sinai Med. Ctr. and Univ. Hosps. Case Med. Ctr.,
Case Western Reserve Univ.
B729 1165.19 Phosphoproteomic analysis of signaling
responses to angiotensin II in proximal tubules of NHE3deficient mice. X.C. Li, E. Miguel-Qin, G.E. Shull and J.L.
Zhuo. Univ. of Mississippi Med. Ctr. and Univ. of Cincinnati Col.
of Med.
B730 1165.20 Complementation of juxtaglomerular cell
granulation in ren-1d null mice by human renin. C. Buckley,
R. Nelson, M. Sharp, S. Flemming, C. Kenyon, L. Mullins, D.
Steppan and J. Mullins. Univ. of Edinburgh, Univ. of Dundee,
U.K. and Univ. of Regensburg, Germany.
B731 1165.21 Markers of acute cardiovascular inflammation
induced by angiotensin II in a murine model. A.B.C. Santana,
T. Souza-Oliveira, V. Barauna, L. Souza, M.C. Irigoyen, L.
Campos, J.E. Krieger and S. Lacchini. Univ. of São Paulo.
B732 1165.22 Angiotensin II receptor signaling modulates
vascular smooth muscle sensitivity to nitric oxide in an
adiposity-specific manner in healthy adults. D.D. Christou,
M-H. Hwang, A.E. Walker, M. Zigler and D.R. Seals. Univ. of
Florida and Univ. of Colorado Boulder.
B733 1165.23 Acute mineralocorticoid receptor blockade
leads to decreased vascular endothelial function in healthy
older adults. H.K. Kim, M-H. Hwang, J-K. Yoo, M.J. Luttrell,
T.H. Meade, M.W. English and D.D. Christou. Univ. of Florida
and Texas A&M Univ. Hlth. Sci. Ctr.
Join Us Next Year!
Experimental Biology 2014
April 26 – 30
San Deigo, CA
American Association of Anatomists (AAA)
The American Physiological Society (APS)
American Society for Biochemistry and Molecular Biology (ASBMB)
American Society for Investigative Pathology (ASIP)
American Society for Nutrition (ASN)
American Society for Pharmacology and Experimental Therapeutics (ASPET)
For further information:
www.experimentalbiology.org
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