program
Transcription
program
16:30-18:00 Poster tuor 18:00Banquet 16:30-17:30 13-4: Epidemiology JTD:Japan Trophoblast Disease Study Group 14:40-16:50 12-4: Regional Perspectives of Gestational Trophoblastic Disease 13:30-16:00 13-3: Trophoblastic Neoplasia 13:00-14:20 12-3: Staging (Evolution of the Staginging and Classification in the Management of GTD) 14:20-14:40 Coffee Break 16:00-16:30 Coffee Break 12:20-13:20 Lunch (Lecture) Dr. Seung Jo Kim 12:00-13:00 Lunch (Lecture) Dr. Barry Hancock 16:50Closing Ceremony 15:10-16:50 14-5: hCG 14:10-15:10 14-4: Trophoblast Differentiation and Fetomaternal Disease ISSTD:International Society for the Study of Trophoblastic Diseases 15:20-16:10 JPA (Japanese oral session-3) (Room 2 Navis B) 14:20-15:20 JPA (Japanese oral session-2) (Room 2 Navis B) 12:40-14:10 14-3: Imaging 11:40-12:10 Annual General Meeting 10:20-12:20 13-2: Trophoblast Differentiation and Fetomaternal Disease 10:40-11:40 12-2: Molecular Genetics and Genome Imprinting 2 13:30-14:20 JPA (Japanese oral session-1) (Room 2 Navis B) 10:20-11:40 14-2: Placental Site Trophoblastic Tumors 10:00-10:20 Coffee Break 10:10-10:40 Coffee Break Nov.14 Wed Room 1 (Argos E) other rooms 8:00-16:50 8:00-9:00 Registration JPA Business Meeting (Board Room) 9:00-10:20 14-1: Hydatidiform Mole Nov.13 Tue other rooms Room 1 (Argos E) 8:00-18:00 8:00-9:00 Registration JPA Council Meeting (Board Room) 9:00-10:00 13-1: Quiscent GTD Nov.12 Mon Room 1 (Argos E) other rooms 8:00-18:00 8:00-9:00 Registration JTD Business Meeting (Kashi) 9:00-10:10 Poster 12-1: (Navis B) Molecular Genetics and Genome Imprinting 1 18:00Opening Ceremony and Welcome party (Mombasa) JPA:Japan Placental Association 16:00-18:00 ISSTD Meeting of the Executive Committee (Kashi) 15:00-20:00 Registration Nov.11 Sun 14th World Congress on Gestational Trophoblastic Diseases Committees ISSTD Officers (Executive Committee) President Seung Jo Kim Secretary-Treasurer Michael Seckl Secretary/Treasurer Elect, representative for the Journal of Reproductive Medicine Journal Editor (effective 9/05) Vilmos Fullop Previous President Ernest Kohorn Website manager, Previous Secretary Laurence A. Cole President Elect (effective 9/07) Barry Hancock Ross Berkowitz Officer for Southeast Asia L C Wong for Southeast Asia Shigeru Sasaki for Europe Leon Massuger for the Middle East Shaoul Anteby for Australasia Stephen Steigrad for the USA Don Goldstein John Lurain for South America Rafael Cortes Charry co-opted member Philip Savage Korean Representative Chan Lee Chinese Representative Xiang Yang Indian Representative P.K Sakharan Local Organizing Committee Honorary Advisory Board Akira Amemiya Hiroshi Kato Matsuto Mochizuki Yuji Murata Yukihiro Nagata Iwao Nishiya Hiroaki Soma Hajime Sugimori Hiroyoshi Takamizawa Ichiro Taki Yutaka Tomoda Naoki Tsukamoto Congress President Norio Wake Secretary-General Tadao Tanaka Toshiharu Kamura 2 The 16th Meeting of Japan Placenta Association The 26th Meeting of Japan Tropboblastic Disease study group 14th World Congress on Gestational Trophoblastic Diseases Committees Deputy Secretaries Auditors Presidential Advisory Committee Scientific Committee Toshio Hirakawa Hiroaki Kobayashi Kotaro Fukushima Yousuke Ueoka Kozo Ohama Hitoo Nakano Masaomi Takayama Shingo Fujii Takeshi Maruo Yuji Taketani Masamichi Kashimura Setsuko Goto Seung Jo Kim Shigeru Saito Hideo Matsui Norimasa Sagawa Tsutomu Dochi Satoshi Hayakawa Bunpei Ishizuka Tsuyoshi Iwasaka Naohiro Kanayama Hidetaka Katabuchi Kiyoko Kato Tatsuhiko Kawarabayashi Fumitaka Kikkawa Yoshiki Kudo Takashi Minegishi Toru Sugiyama Kiyomi Tsukimori Kimio Ushijima Kenzo Sonoda Chairperson Chairperson Vice Chairperson Vice Chairperson Members Budget Committee Noriyuki Inaba Chairperson Registration Committee Kazuhiko Hoshi Chairperson Congress Site Committee Hideharu Kanzaki Chairperson Exhibition Committee Ikuo Konishi Chairperson Publicity & promotion Committee Keiichi Isaka Chairperson Hospitality Committee Shigeru Sasaki Chairperson Publication Committee Naohiro Kanayama Chairperson 3 14th World Congress on Gestational Trophoblastic Diseases Welcome Message It is a great pleasure to welcome you all to the 14th World Congress on Gestational Trophoblastic Diseases, which will be held in Fukuoka, Japan from November 11 to 14, 2007. This Meeting will be held in conjunction with the 15th Meeting of Japan Placenta Association and the 25th Meeting of Japan Trophoblast Disease study group. The Venue is JAL Resort Sea Hawk Hotel, located in the sea-side of Fukuoka city that will enable us to offer attractive and comfortable accommodation with convenient access to the scientific sessions, giving us a beautiful view of Hakata Gulf and downtown of Fukuoka city on its both sides. Japan is very honored to host the 14th World Congress on Gestational Trophoblastic Diseases in Fukuoka city. The scientific program will be lined up with a host of exciting and enlightening presentations by prominent international experts on the latest developments and findings in the field of trophoblast research. The congress will definitely provide an invaluable opportunity for friends of the region as well as those outside the region to share experiences and exchange scientific information. The local organizing committee is making every effort to put together an exciting program under the collaboration with the 15th Meeting of Japan placenta Association and the 25th Meeting of Japan Trophoblastic Disease Study Group. Fukuoka is the biggest city in Kyushu, which is a western part of Japan. I would like to extend an invitation to you to come and visit us. Apart from the congress, I am sure you will find many attractions and enjoy the experience of bustling and vibrant city life of Fukuoka. We warmly invite all of you, especially young investigators, your families and those coming to visit Japan for the first time, to participate in the 14th World Congress on Gestational Trophoblastic Diseases in Fukuoka, Japan. We very much look forward to welcoming you in Fukuoka in November 2007. Sincerely, Prof. Norio Wake Congress President The 14 World Congress on Gestational Trophoblastic Diseases. 4 14th World Congress on Gestational Trophoblastic Diseases General Information Event Title 14th World Congress on Gestational Trophoblastic Diseases Title of the Simultaneous Event 15th Meeting of Japan Placenta Association 25th Meeting of Japan Trophoblast Disease Study Group. Host Organizer Organising Committee for the 14th World Congress on Gestational Trophoblastic Diseases Co-host Japan Placenta Association Japan Trophoblastic Disease Study Group Supporting Body Fukuoka City Japan Society of Obstetrics and Gynecology Japan Association of Obstetrics and Gynecology Date November 11-14, 2007 Venue JAL Resort Sea Hawk Hotel Fukuoka 2-2-3 Jigyohama, Chuo-ku, Fukuoka City 810-8650 JAPAN Tel: +81-92-844-8111 Fax: +81-92-844-7887 http://www.hawkstown.com/hotel/english/index.html Secretariat c/o MA Convention Consulting Inc. 5F, Dai 2 Izumi-shoji Bldg., 4-2-6 Kojimachi, Chiyoda-ku, Tokyo 102-0083, JAPAN TEL: +81-3-5275-1191 / FAX: +81-5275-1192 Website http://www.macc.jp/14isstd/ Official Language English and Japanese Registration & PC Preview Date Registration Desk PC Preview Desk Sunday, November 11 15:00-20:00 - Monday, November 12 8:00-18:00 8:00-17:00 Tuesday, November 13 8:00-18:00 8:00-17:00 Wednesday, November 14 8:00-16:50 8:00-16:50 Receipts must be presented in order to receive Program & Abstracts, Name Card, Certificate of Attendance and Congress Bag. At On-site Registration Desk, payments of registration fee can be made by cash or credit cards. (VISA, JCB, American Express and MasterCard are accepted.) 5 14th World Congress on Gestational Trophoblastic Diseases General Information Internet Access / Fax / Copy Internet access, Fax and copy services are available at Guest Relation Desk (4th Fl of the hotel). Certificate of Attendance Certificate of Attendance will be provided at Registration Desk. Refreshment Breakfast and coffee will be served in Navis A on the 1st Fl. Cloak Cloak is on the 1st Fl. of the hotel. Weather The temperature in Fukuoka in November ranges between 9°C / 48°F and 17°C / 63°F. Shopping Shops and other sales outlets in Japan are generally open on Saturdays, Sundays and national holidays as well as weekdays from 10:00 to 20:00. Department stores, however, are closed on one weekday, differing by store, and certain specialty shops may not open on Sundays and national holidays. Currency Exchange Only Japanese yen (¥) is acceptable at regular stores and restaurants. Certain foreign currencies may be accepted at a limited number of hotels, restaurants and souvenir shops. You can buy yen at foreign exchange banks and other authorized money exchangers on presentation of your passport. Traveler’s Checks and Credit Cards Traveler’s checks are accepted only by leading banks and major hotels in principal cities, and the use of traveler’s checks in Japan is not as popular as in some other countries. VISA, MasterCard, Diners Club, and American Express are widely accepted at hotels, department stores, shops, restaurants and nightclubs. Tipping In Japan, tips are not necessary anywhere, even at hotels and restaurants. Electricity Electric current is uniformly 100 volts, AC, throughout Japan, but with two different cycles: 50Hz in eastern Japan including Tokyo, and 60Hz in western Japan including Fukuoka, Kyoto and Osaka. Leading hotels in major cities have two outlets of 100 and 220 volts but their sockets usually accept a two-leg plug only. 6 14th World Congress on Gestational Trophoblastic Diseases Floor Plan 7 14th World Congress on Gestational Trophoblastic Diseases General Information 8 14th World Congress on Gestational Trophoblastic Diseases General Information 9 14th World Congress on Gestational Trophoblastic Diseases Access to Fukuoka NARITA INTERNATIONAL AIRPORT (NRT) KANSAI INTERNATIONAL AIRPORT ( KIX ) By Domestic Flight JPY 19,500 / 75 min. 6 flights per day By Domestic Flights JPY 32,700 / 130 min. 3 flights per day CENTRAL JAPAN INTERNATIONAL AIRPORT ( CENTAIR ) By Airport Bus JPY 3,000 / 75min. Dep.time: 06:55- 21:20 ( every 10-40 ) TOKYO INTERNATIONAL AIRPORT ( HANEDA ) By Domestic Flights JPY 22,500 / 85 min. 20 flights per day By Domestic Flights JPY 32,700 / 90min. 45 flights per day FUKUOKA AIRPORT 6 min. HAKATA STATION 7 min. walk 2 min. 5 min. walk GION STATION 20-25min. by taxi approx.JPY2,000-2,500 Chisan Hotel Hakata 20 min. by taxi approx. JPY2,500 1 min NAKASU KAWABATA STATION 1 min. walk Hakata Excel Hotel Tokyu 4 min. walk 1 min TENJIN STATION ( TENJIN BUS TERMINAL ) 10 min. walk 15 min. walk Hakata Nakasu Washington Hotel Plaza by Subway 5 min. 10-15 min. by taxi approx.JYP1,500 TOJINMACHI STATION 15 min. on foot 15 min. by bus / JPY220 6:39-23:45 / Every 10–15 min. JAL Resort Sea Hawk Hotel Fukuoka (Venue) 10 14th World Congress on Gestational Trophoblastic Diseases Map of the Venue 11 14th World Congress on Gestational Trophoblastic Diseases 会場へのアクセス 福 岡 空 港 福岡空港より 博多/祇園/中洲川端/天神 250 円 唐人町 290 円 唐人町より 博多/祇園/中洲川端 250 円 天神 200 円 地下鉄 1 号線(空港線) タクシー(空港-各ホテル) 約 20-25 分/約 2,000-2,500 円 タクシー(空港-会場) 約 20 分/約 2,500 円 6 分 博 多 駅 徒歩 7 分 2 分 徒歩 5 分 祇 園 駅 チサンホテル博多 1 分 中洲川端駅 徒歩 1 分 博多エクセルホテル東急 徒歩 10 分 1 分 徒歩 4 分 天 神 駅 (天神バスターミナル) 徒歩 15 分 博多中洲ワシントン ホテルプラザ タクシー(駅-会場) 約 15 分/約 2,000 円 バス(駅-会場) 博多駅交通センター 又は博多駅前 約 25 分/220 円 5 分 唐人町駅 徒歩 15 分 バス(天神バスターミナル-会場) 約 15 分/220 円 タクシー(各ホテル-会場) 10-15 分/約 1,500 円 JAL リゾートシーホークホテル福岡 (会場) 12 14th World Congress on Gestational Trophoblastic Diseases 会場の地図 13 14th World Congress on Gestational Trophoblastic Diseases Social Events Opening Ceremony & Welcome Party Date: Sunday, November 11, 18:00Place: Mombasa (5th Fl.) Banquet Date: Tuesday, November 13, 18:00Place: Zepp Fukuoka Closing Ceremony Date: Wednesday, November 14, 16:50Place: Argos E (1st Fl.) Zepp Fukuoka Access Map 14 14th World Congress on Gestational Trophoblastic Diseases Meetings ISSTD Executive Committee Date: Sunday, November 11, 16:00-18:00, Place: Kashi(1st Fl.) ISSTD Annual General Meeting Date: Wednesday, November 14, 11:40-12:10 Place: Argos E (1st Fl.) JTD Business Meeting Date: Monday, November 12, 8:00-9:00 Place: Kashi(1st Fl.) JPA Council Meeting Date: Tuesday, November 13, 8:00-9:00 Place: Board Room (3rd Fl.) JPA Business Meeting Date: Wednesday, November 14, 8:00-9:00 Place: Board Room (3rd Fl.) 15 16 Kashi (1st Fl.) foyer in front of Argos E (1st Fl.) Banquet Lobby Navis A&B (1st Fl.) Room 1 Argos E (1st Fl.) Place / Time 8:00 JTD Business Meeting Monday, November 12 Kashi (1st Fl.) Banquet Lobby Mombasa (5th Fl.) Place / Time Sunday, November 11 9:00 Exhibition Session 12-1 Coffee Break 13:00 PC Preview Coffee Break 14:20 14:40 Poster Session Session 12-3 Registration Exhibition Luncheon Seminar 11:40 12:00 Session 12-2 10:10 10:40 15:00 Poster Tour 16:30 17:00 18:00 Registration 17:30 18:00 Executive Committee Meeting Exhibition Session 12-4 16:00 Opening Ceremony and Welcome Party 20:00 14th World Congress on Gestational Trophoblastic Diseases Program at a glance 9:00 JPA Council Meeting 8:00 Board Room (3rd Fl.) JPA Business Meeting PC preview ISSTD Annual Meeting foyer in front of Argos E (1st Fl.) Session 14-2 11:40 12:10 12:40 Registration 10:20 Banquet Lobby 9:00 PC Preview Session 14-3 Registration Exhibition 14:10 Session 14-4 15:10 Session 14-5 Coffee Break 16:50 17:30 18:00 Closing Ceremony Session 13-4 15:20 16:00 16:10 16:30 JPA JPA Session 2 Session 3 Session 13-3 14:20 JPA Session 1 13:20 13:30 Luncheon Seminar Exhibition 8:00 Session 13-2 12:20 Navis A Room 1 Argos E Place / Time Coffee Break 10:00 10:20 Session 14-1 Session 13-1 Wednesday, November 14 Board Room (3rd Fl.) Zepp Fukuoka foyer in front of Argos E (1st Fl.) Banquet Lobby Navis A (1st Fl.) Room2 Navis B (1st Fl.) Room 1 Argos E (1st Fl.) Place / Time Tuesday, November 13 Banquet 14th World Congress on Gestational Trophoblastic Diseases 17 14th World Congress on Gestational Trophoblastic Diseases Notes for Speakers Oral presentation Oral presentations will take place in the Room1 (Argos E) or Room2(Navis B) on the 1st floor of JAL Resort Sea Hawk Hotel Fukuoka. All presentations should be given in Microsoft PowerPoint 2000/2002/2003 on a PC. Speakers are asked to submit their presentations on a CD-R (not CD-RW) or an USB memory stick to the technician on the PC Preview Desk at least one hour before their presentation. If you wish to use Macintosh computer, Powepoint 2007(Windows VISTA/Windows XP) or moving images, please bring your own laptop and report to the technician on the PC Preview Desk at least one hour before your presentation. Oral presentation of invited speakers will be 15 minutes followed by 5-minute discussion, and that of other speakers will be 6 minutes followed by 4-minute discussion. Due to the time schedule, speakers must ensure their presentation does not exceed this time limit. Poster Presentation Posters can be displayed in the Room2 (Navis B) on November 12. Set-up and Removal Hours: Registration and Set-up: Monday, November 12, 8:00-11:00 Removal: Monday, November 12, 18:00-19:00 Poster Tour: Poster presenters are expected to be present at their display during the following hours: Monday, November 12, 16:30-18:00 for Poster Tour. Please Note: * Poster size: 90cm x 120cm (portrait) * A presentation number to be placed at the top left of the poster will be provided by the secretariat. * Each author is requested to indicate "the title," "the authors' names" ,"the authors' affiliations" and "research content". * Posters should be attached to the boards with thumbtacks provided by the Secretariat. No paste, glue, staples or nails should be permitted. * Any posters remaining after 19:00 November 12 will be removed and disposed of by the Secretariat. 18 Scientific Program 14th World Congress on Gestational Trophoblastic Diseases Scientific Program Sunday, November 11 15:00-20:00 Registration 16:00-18:00 Meeting of the ISSTD Executive Committee 18:00- Opening Ceremony and Welcome Party Monday, November 12 8:00-18:00 Registration 8:00-9:00 JTD Business Meeting 11:00-18:00 Poster Presentation SESSION 12-1 : Molecular Genetics and Genome Imprinting 1 Chairperson : Rosemary Fisher (UK) 9:00-9:20 S12-1-1 FAMILIAL RECURRENT HYDATIDIFORM MOLES Rosemary Fisher1,2), Peter Dixon1), Shaun Decordova1), Neil Sebire2), Philip Savage2), Michael Seckl2) 1) Institute of Reproductive and Developmental Biology, Imperial College London, UK 2) Trophoblastic Screening and Treatment Centre, Charing Cross Hospital, UK 9:20-9:40 S12-1-2 HUMAN EMBRYONIC STEM CELL GENES IN GESTATIONAL TROPHOBLASTIC DISEASES Annie NY Cheung The University of Hong Kong, China 9:40-10:00 S12-1-3 IMMUNE CELL PROFILING IN NORMAL PREGNANCY, PARTIAL AND COMPLETE MOLAR PREGNANCY Zoltan Nagymanyoki1), M.J. Callahan1), M.M. Parast2), V. Fulop3), S.C. Mok1), R.S. Berkowitz1) 1) Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, USA 2) Division of Women’s and Perinatal Pathology, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA 3) Department of Obstetrics and Gynecology, State Health Center, Budapest, Hungary 20 14th World Congress on Gestational Trophoblastic Diseases 10:00-10:10 S12-1-4 MOLAR PLOIDY IN TWIN PREGNANCIES COMPRISING HYDATIDIFORM MOLE AND CO-EXISTING NORMAL FETUS Isa Niemann1), L Bolund2), L Sunde1) 1) Dept of clinical genetics, Aarhus University Hospital, Denmark 2) Insitute of Human Genetics, Aarhus University, Denmark 10:10-10:40 Coffee Break SESSION 12-2 : Molecular Genetics and Genome Imprinting 2 Chairperson: Fumitoshi Ishino (Japan) 10:40-11:00 S12-2-1 P57KIP2 IMMUNOSTAINING AND MOLECULAR CYTOGENETICS: COMBINED APPROACH FOR CHIMERIC, MOSAIC AND MORPHOLOGICALLY CHALLENGING CASES WITH MOLAR PHENOTYPE Urvashi Surti, Lori Hoffner Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA 11:00-11:20 S12-2-2 PLACENTAL DEFECTS IN MICE LACKING MATERNAL METHYLATION IMPRINTS Kenichiro Hata Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Japan 11:20-11:40 S12-2-3 ESSENTIAL ROLES OF RETROTRANPOSON-DERIVED IMPRINTED GENES, PEG10 AND PEG11/RTL1, IN MAMMALIAN PLACENTA DEVELOPMENT AND EVOLUTION Fumitoshi Ishino1), Ryuichi Ono1), Yoichi Sekita1), Sunsuke Suzuki1), Takashi Kohda1), Tomoko Kaneko-Ishino2) 1) Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, Japan 2) Tokai University, School of Health Sciences, Japan 12:00-13:00 Luncheon Seminor supported by Bristol Myers K.K. Chairperson: Ernest Kohorn (USA) GESTATIONAL TROPHOBLASTIC NEOPLASIA - TREATMENT BEYOND SINGLE AGENTS Barry Hancock(UK) Trophoblastic Tumour Centre, Weston Park Hospital, Sheffield, UK SESSION 12-3 : Staging (Evolution of the Staging and Classification in the Management of GTD) Chairperson: Hextan YS Ngan(China) 13:00-13:20 S12-3-1 DYNAMIC STAGING AND RISK FACTOR SCORING SYSTEM FOR GESTATIONAL TROPHOBLASTIC DISEASE Ernest I. Kohorn Department Gynecology, Yale University School of Medicine, USA 21 14th World Congress on Gestational Trophoblastic Diseases 13:20-13:40 S12-3-2 Evolution of the Staginging and Classification in the Management of GTD Hextan.Y.S.Ngan Department of Obstetrics & Gynaecology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, SAR, China 13:40-14:00 S12-3-3 JAPANESE TRIAL FOR CLASSIFICATION OF GESTATIONAL TROPHOBLASTIC DISEASES Shigeru Sasaki Ebina General Hospital, Japan 14:00-14:20 S12-3-4 AN EVALUATION OF FIGO 2000 - THE FIRST 5 YEARS Barry Hancock, Alicia Okines Trophoblastic Tumour Centre, Weston Park Hospital, Sheffield, UK 14:20-14:40 Coffee Break SESSION 12-4 : Regional Perspectives of Gestational Trophoblastic Disease Chairperson: Vilmos Fülӧp (Hungary) 14:40-15:00 S12-4-1 GESTATIONAL TROPHOBLASTIC DISEASES-THE INDIAN PERSPECTIVE P K Sekharan1), N S Sreedevi1), Rasheeda Beegam2), B Presannakumari2), Sheela Shenoy3), Umadevi3), U D Bafna 1) Medical College, Calicut, India. 2) Medical College, Trivandrum, India. 3) Kidwai Memorial Institute Of Oncology,Bangalore, India. 15:00-15:20 S12-4-2 THE DIAGNOSTICS AND TREATMENT OF HIGH RISK GTN IN HUNGARY Vilmos Fulop1), Ivan Szigetvari1), Janos Szepesi2), Miklos Torok1), Ross S. Berkowitz3) 1) Dept OB/GYN, State Health Center, Budapest, Hungary 2) Dept OB/GYN, Gyula Nyiro Hospital, Budapest, Hungary 3) Dept OB/GYN, Brigham and Women’s Hospital, Boston, Massachusetts 15:20-15:40 S12-4-3 REGIONAL PERSPECTIVES OF GESTATIONAL TROPHOBLASTIC DISEASEBRAZILIAN REFERRAL CENTERS Izildinha Maesta Trophoblastic Diseases Center of the Department of Gynecology and Obstetrics, Botucatu Medical School, Sao Paulo State University-UNESP, Brazil 15:40-16:00 S12-4-4 REGIONAL PERSPECTIVES OF GESTATIONAL TROPHOBLASTIC DISEASE IN TURKEY S. Sinan Ozalp Department of Gynecology and Obstetrics, Faculty of Medicine, Eskisehir Osmangazi University, Turkey. 22 14th World Congress on Gestational Trophoblastic Diseases 16:00-16:20 S12-4-5 NATION WIDE REGISTRY FOR MOLAR DISEASE IN THE NETHERLANDS Leon Massuger Radboud University Nijmegen Medical Centre, Department of Obstetrics and Gynaecology, Netherlands 16:20-16:30 S12-4-6 GESTATIONAL TROPHOBLASTIC NEOPLASIA TEATMENT RESULTS AT THE JOHN I. BREWER TROPHOBLASTIC DISEASE CENTER 1979-2006 COMPARED TO 1962-1978. Anna V Hoekstra1), JR Lurain1), AW Rademaker2), JC Schink1) 1) Division of Gynecologic Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL USA 2) Department of Preventive Medicine, Feinberg School of Medicine, Chicago, IL USA 16:30-16:50 S12-4-7 EVALUATION OF GESTATIONAL TROPHOBLASTIC NEOPLASIA TREATMENT IN 167 PATIENTS Francois Golfier, C. Labrousse, L. Frappart, B. Mathian, J.P. Guastalla, V. Trillet-Lenoir, T. Hajri, A.M. Schott, D. Raudrant. French Trophoblastic Disease Reference Center, Hôtel-Dieu, 69002 Lyon, France Poster Tour 16:30-18:00 LIST OF POSTER RESENTATION Please refer to the end of the program 23 14th World Congress on Gestational Trophoblastic Diseases Tuesday, November 13 8:00-18:00 Registration 8:00-9:00 JPA Council Meeting SESSION 13-1: Quiscent GTD Chairperson: Ernest Kohorn (USA) 9:00-9:20 S13-1-1 THE MANAGEMENT OF FALSE POSITIVE HCG AND QUIESCENT GESTATIONAL TROPHOBLASTIC DISEASE Ernest I Kohorn1), Laurence A Cole2) 1) Trophoblast Center, Department Gynecology, Yale University School of Medicine, USA 2) University of New Mexico, Albuquerque, New Mexico. 9:20-9:40 S13-1-2 QUIESCENT GESTATIONAL TROPHOBLASTIC NEOPLASIA Barry Hancock1), Jan Everard1), Dave Drew1), Melanie Boafo-Yirenkyi2), Michael Seckl1), John Tidy 1) Trophoblastic Tumour Centre, Weston Park Hospital, Sheffield, UK 2) Charing Cross Hospital, London, UK 9:40-10:00 S13-1-3 QUIESCENT GTD AND MINIMALLY INVASIVE GTD Laurence A Cole USA hCG Reference Service, Obstetrics and Gynecology, University of New Mexico, USA 10:00-10:20 Coffee Break SESSION 13-2: Trophoblast Differentiation and Fetomaternal Disease Chairperson: Norimasa Sagawa (Japan) 10:20-10:40 S13-2-1 EPIGENETIC CHANGE DURING TROPHOBLAST DIFFERENTIATION Satoshi Tanaka, J. Tomikawa, N. Hattori, K. Hayakawa, J. Ohgane, S. Yagi, K. Shiota Animal Resource Sci. / Vet. Med. Sci., The Univ. of Tokyo, Japan. 10:40-11:00 S13-2-2 PLACENTAL PATHOLOGY OF IUGR AND TROPHOBLASTIC MIGRATION Masahiro Nakayama, Yuko Kuwae, Keiko Matsuoka, Masayoshi Arizawa, Noriyuki Suehara Osaka Medical Center and Research Institute for Maternal and Child Health, JAPAN 24 14th World Congress on Gestational Trophoblastic Diseases 11:00-11:20 S13-2-3 LOCAL REGULATION OF UTERINE LYMPHOCYTES IN HUMAN Shigeru Saito, Akitoshi Nakashima, Mika Ito, Tomoko Shima, Arihiro Shiozaki University of Toyama, Japan 11:20-11:40 S13-2-4 TROPHININ-MEDIATED CELL ADHESION AS A MOLECULAR SWITCH FOR ErbB4 ACTIVATION IN HUMAN EMBRYO IMPLANTATION Kazuhiro Sugihara Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Japan 11:40-12:00 S13-2-5 ROLE OF ANTIOXIDANT SYSTEM IN THE FETAL GROWTH - OVEREXPRESSION OF THIOREDOXIN-1 PROMOTES THE FETAL GROWTH IN MICE Takashi Umekawa, Takashi Sugiyama, Tomohisa Kihira, Nao Murabayashi, Lingyun Zhang, Kenji Nagao, Yuki Kamimoto, Norimasa Sagawa Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Japan 12:00-12:20 S13-2-6 INVESTIGATION ON GENES INVOLVED IN THE ENDOVASCULAR INVASION OF HUMAN EXTRAVILLOUS TROPHOBLAST Kotaro Fukushima, Masaharu Murata, Masahiro Hachisuga, Kazuo Asanoma, Kiyomi Tsukimori, Norio Wake Kyushu University, Fukuoka, Japan 12:20-13:20 Luncheon Seminor supported by GE Healthcare Chairperson: Toshiharu Kamura (Japan) IMPROVING OUTCOME OF THE TREATMENT IN THE HIGH RISK GTD FROM THE PAST TO THE FUTURE Seung Jo Kim(Korea) Pochon cha university, Korea Gynecologic cancer center SESSION 13-3: Trophoblastic Neoplasia Chairperson: Michael J Seckl (UK) 13:30-13:50 S13-3-1 RESULTS OF TREATMENT OF PATIENTS WITH GESTATIONAL TROPHOBLASTIC NEOPLASIA REFERRED TO A TROPHOBLASTIC DISEASE CENTER AFTER FAILURE OF TREATMENT ELSEWHERE John R. Lurain, Anna V. Hoekstra, Julian C. Schink Brewer Trophoblastic Disease Center, Northwestern University Feinberg School of Medicine, USA 13:50-14:10 S13-3-2 THE PROGNOSIS OF GESTATIONAL TROPHOBLASTIC NEOPLASIA- CLINICAL EXPERIENCES OF PUMC HOSPITAL FROM 1985 TO 2005 Xiang Yang, YANG Jun-jun, WAN Xi-run, YANG Xiu-yu Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, China 25 14th World Congress on Gestational Trophoblastic Diseases 14:10-14:30 S13-3-3 IDENTIFICATION AND TREATMENT OF HIGH TROPHOBLASTIC NEOPLASIA John Tidy, J Palmer, J Everard, N Hough, R Coleman, B Hancock RISK GESTATIONAL Sheffield Trophoblastic Disease Centre, Weston Park Hospital, Sheffield, UK 14:30-14:50 S13-3-4 MANAGEMENT OF GESTATIONAL TROPHOBLASTIC NEOPLASIA (GTN) AFTER EMA/CO: AN UPDATE ON TE/TP, HIGH DOSE AND OTHER NOVEL THERAPIES. Michael J Seckl1), J Wang1), D Short1), I Lindsay1), NJ Sebire1), A Lim1), ES Newlands1), B Hancock2), P Schmid1), PM Savage1) 1) Charing Cross Gestational Trophoblastic Disease Centre, Imperial College Hospitals, UK 2) Sheffield Gestational Trophoblastic Disease Centre, Weston Park Hospital, UK 14:50-15:10 S13-3-5 EARLY CHEMOTHERAPY OF HIGH RISK HYDATIDIFORM MOLE Chan Lee, YJ Na, SY Lee, SJ Kim, SG Jung, YY Hwang Pochon CHA University Budang CHA Medical Center, College of Medicine Comprehensive Gynecologic Cancer Center South Korea 15:10-15:30 S13-3-6 MANAGEMENT OF LOW RISK GESTATIONAL TROPHOBLAST DISEASE Philip Savage, D Short, I Lindsay, NJ Sebire, A Lim, H Mitchell, R Harvey, P Schmid, MJ Seckl Dept of Medical Oncology Charing Cross Hospital London UK 15:30-15:50 S13-3-7 A RANDOMIZED PHASE Ⅲ TRIAL COMPARING WEEKLY PARENTERAL METHOTREXATE AND ”PULSED” DACTINOMYCIN AS PRIMARY MANAGEMENT FOR LOW-RISK GESTATIONAL TROPHOBLASTIC NEOPLASIA (GTN): A GYNECOLOGIC ONCOLOGY GROUP STUDY (G.O.G.) Raymond Osborne1), V Filiaci2), J Schink3), D Miller4), A Covens1), R Mannel5) 1) 2) 3) 4) 5) 15:50-16:00 University Of Toronto, Canada Gynecologic Oncology Group, Canada Northwestern University, Canada University Of Texas (Southwestern), Canada University Of Oklahoma, Canada S13-3-8 VAGINAL METASTASES IN GESTATIONAL TROPHOBLASTIC NEOPLASIA Emily Berry, George S. Hagopian, John R. Lurain Brewer Trophoblastic Disease Center, Northwestern University Feinberg School of Medicine, Chicago IL, USA 16:00-16:30 Coffee Break SESSION 13-4: Epidemiology Chairperson: Raymond Osborne(Canada) 16:30-16:50 S13-4-1 REGISTRATION SYSTEM AND THE TROPHOBLASTIC DISEASE IN JAPAN Kazuhiko Ino, F. Kikkawa INCIDENCE OF GESTATIONAL Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Japan 26 14th World Congress on Gestational Trophoblastic Diseases 16:50-17:10 S13-4-2 THE CHANGES OF CLINICAL FEATURES OF HYDATIDIFORM MOLE: Wan Xirun, XIANG Yang, HOU Jinlin PUMC Hospital, Beijing, China 17:10-17:30 S13-4-3 RECENT CHANGES OF THE INCIDENCE FOR COMPLETE AND PARTIAL MOLE IN CHIBA PREFECTURE Hideo Matsui, Maki Kihara, Hirokazu Usui, Emiri Nakata, Makio Shouzu Department of Reproductive Medicine, Chiba University Graduate School of Medicine, Japan 27 14th World Congress on Gestational Trophoblastic Diseases JPA (Japanese Oral Session) Tuesday, November 13 JPA SESSION 1 Chairperson: Kotaro Fukushima(Japan) 13:30-13:40 JPA1-1 MICRORNA EXPRESSION PROFILING OF NORMAL HUMAN PLACENTA BY EXTENSIVE CLONING ANALYSIS Toshihiro Takizawa1), S-S Luo1), T Mishima1), G Ishikawa2), Y Kawahigashi1), T Kanda1), Y Mizuguchi1), T Takizawa1), S Matsubara3), T Takeshita2) 1) Department of Molecular Anatomy and Medicine, Nippon Medical School, Tokyo, Japan 2) Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan 3) Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi, Japan 13:40-13:50 JPA1-2 EPIGENETIC STABILITY AND DEVELOPMENTAL PLASTICITY IN CLONED PLACENTAE DURING SOMATIC CELL NUCLEAR TRANSFER Naomi Matsuda1), Sharif Jafar1), Kimiko Inoue2), Narumi Ogonuki2), Hiromi Miki2), Hiroshi Chisaka1), Kunihiro Okamura1), Atsuo Ogura2), Kohzoh Mitsuya3) 1) Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Japan 2) Bioresource Engineering Division, RIKEN Bioresource Center, Japan 3) Biofunctional Science, Tohoku University Biomedical Engineering Research Organization (TUBERO), Japan 13:50-14:00 JPA1-3 INVOLVEMENT OF OLIGOSACCHARIDE CHANGES IN α 5β1 INTEGRIN IN INVASION OF EXTRAVILLOUS TROPHOBLASTS Eiko Yamamoto, Kazuhiko Ino, Kumiko Kidokoro, Noriko Takahashi, Norio Yoshida, Akiko Nakagawa, Seiji Sumigama, Fumitaka Kikkawa Nagoya University Graduate School of Medicine, Japan 14:00-14:10 JPA1-4 THE EFFECTS OF ANTI β 2-GPI ANTIBODY POSITIVE SERA ON PLGF PRODUCTION FROM CULTURED CHORIOCARCINOMA CELL Souichiro Kuno, Tatsuo Yamamoto, Takayuki Murase, Go Ichikawa, Youji Akoki Department of Obstetrics and Gynecology, Nihon University School of Medicine, Japan 14:10-14:20 JPA1-5 cAMP DEPENDENT INDUCTION OF HUMAN CHORIONIC GONADOTROPIN (hCG) BY TOLL LIKE RECEPTOR (TLR) 3 AND 9 SIGNALING IN A CHORIOCARCINOMA CELL LINE BEWO Shihoko Komine-Aizawa1), Hiroko Majima1), Chikako Yoshida-Noro2), Satoshi Hayakawa1) 1) Department of Pathology and Microbiology, Division of Microbiology, Nihon University School of Medicine, Japan 2) Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Japan 28 14th World Congress on Gestational Trophoblastic Diseases JPA SESSION 2 Chairperson: Shigeru Saito(Japan) 14:20-14:30 JPA2-1 EARLY DETECTION OF POST-MOLAR PERSISTENT HCG FOLLOWING EARLY STAGE HYDATIDIFORM MOLE Junya Miyoshi, Takashi Ohba, Kikuko Uchino, Hironori Tashiro, Hidetaka Katabuchi Department of Reproductive Medicine and Surgery / Gynecology, Faculty of Medical and Pharmaceutical Science, Kumamoto University, Japan 14:30-14:40 JPA2-2 ABUNDANCE AND LOCALIZATION OF PROSTAGLANDIN F2αRECEPTOR (FP) mRNA AND PROTEIN AND UTERINE ACTIVATOR PROTEINS IN HUMAN DECIDUA AT PRETERM BIRTH AND TERM BIRTH Shintaro Makino1), Dean B. Zaragoza2), David M. Olson2), Toshitaka Tanaka1), Satoru Takeda1) 1) Department of Obstetrics and gynecology, Juntendo University School of Medicine, Japan 2) Perinatal Research Centre, University of Alberta, Canada 14:40-14:50 JPA2-3 EVALUATION OF THE EXPRESSION AND ENZYME ACTIVITY OF MATRIX METALLOPROTEINASE-7 IN FETAL MEMBRANES DURING PREMATURE RUPTURE OF MEMBRANES AT TERM IN HUMANS Saori Nishihara1), Akimasa Someya2), Hisashi Yonemoto1), Atsuyuki Ota1), Toshitaka Tanaka1), Shigeru Itoh1), Isao Nagaoka2), Satoru Takeda1) 1) Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Japan 2) Department of Host Defense and Biochemical Research, Juntendo University School of Medicine, Japan 14:50-15:00 JPA2-4 A CASE OF PREMATURE LABOR WITH ELEVATION OF PLACENTAL ALKALINE PHOSPHATASE DURING PREGNANCY Junko Suzuki, Kikuko Uchino, Junya Miyoshi, Takashi Ohba, Hidetaka Katabuchi Department of Reproductive Medicine and Surgery / Gynecology, Faculty of Medical and Pharmaceutical Science, Kumamoto University, Japan 15:00-15:10 JPA2-5 NECROTIC DECIDUITIS BASALIS WITHOUT CHORIOAMNIONITIS Masayoshi Arizawa, Hiroyuki Kato Department of Pathology, Tokyo metropolitan Ohtsuka Hospital, Japan 15:10-15:20 JPA2-6 A COMPARISON OF PATHOHISTOGENESIS BETWEEN CHORANGIOMA AND CHORANGIOSIS Gen Ishikawa1), Hiroaki Soma2), Hiroyuki Osawa2), Tatsuo Oguro3), Kayoko Tanaka4), Shoichiro Mineo5) 1) 2) 3) 4) 5) Deparment of Obstetrics & Gynecology, Nippon Medical School, Japan Department of Obstetrics & Gynecology, Saitama Medical School, Japan Nippon Medical School, Chiba Hokuso Hospital, Japan Division of Morphological Science, Saitama Medical School, Japan Department of Pathology, Tokyo Medical University, Japan 29 14th World Congress on Gestational Trophoblastic Diseases JPA SESSION 3 Chairperson: Kiyomi Tsukimori (Japan) 15:20-15:30 JPA3-1 MEASUREMENT OF PLACENTAL OXYGENATION BY TRANSABDOMINAL NEAR-INFRARED SPECTROSCOPY IN NORMAL AND GROWTH RESTRICTED FETUS Kazunao Suzuki1), Kazuhiro Sumimoto2), Kyuya Hirai1), Takakazu Kawamura1), Kayoko Takada1), Satoshi Kimura1), Kinya Takeuchi1), Kazuhiro Sugihara1), Motoi Sugimura1), Naohiro Kanayama1) 1) Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Japan 2) Kawasaki City College of Nursing, Japan 15:30-15:40 JPA3-2 AN ATTEMPT TO EVALUATE THE PLACENTAL FUNCTION BY USING MYOMETRIAL BLOOD FLOW ANALYSIS Tomoo Waseda, Yukio Watanabe, Hideki Tomizawa, Ryouta Fujii, Satoru Makinoda Department of Obstetrics & Gynecology, Kanazawa Medical University, Japan 15:40-15:50 JPA3-3 INVESTIGATION OF MONOCHORIONIC TWINS IN WHICH AT LEAST ONE FETUS HAS A CONGENITAL HEART DISEASE WITH OR WITHOUT TWIN-TWIN TRANSFUSION SYNDROME Nobuhiro Hidaka1,2), Kiyomi Tsukimori1), Yoshihide Chiba2), Norio Wake1) 1) Department of Obstetrics and Gynecology, Kyushu University, Japan 2) Department of Perinatology, National Cardiovascular Center, Japan 15:50-16:00 JPA3-4 INTRAPLACENTAL CHORIOCARCINOMA ASSOCIATED WITH A MASSIVE FETOMATERNAL HEMORRHAGE AT TERM PREGNANCY Kaai Aso1), Yasuo Yumoto1), Satoshi Hojo1), Haruhiko Kondoh2), Nobuhiro Hidaka1), Kotaro Fukushima1), Hiroshi Yagi1), Shinji Ogawa1), Hiroaki Kobayashi1), Kiyomi Tsukimori1), Norio Wake1) 1) Department of Obstetrics and Gynecology, Graduate School of Medical Science,Kyushu University, Fukuoka, Japan 2) Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan 16:00-16:10 JPA3-5 A CASE OF INTRAPLACENTAL CHORIOCARCINOMA RESULTING IN FETOMATERNAL HEMORRHAGE Yayoi Abe, Atsushi Tajima, Takafumi Ujihira, Soushi Kusunoki, Mayuko Maruyama, Fuyuko Nagai, Yuka Yamamoto, Takeshi Taguchi, Noriko Abe, Michio Nojima, Koyo Yoshida Department of Obstetrics and Gynecology, Juntendo Urayasu Hospital, Juntendo University, School of Medicine, Japan 30 14th World Congress on Gestational Trophoblastic Diseases Wednesday, November 14 8:00-16:50 Registration 8:00-9:00 JPA Business Meeting SESSION 14-1: Hydatidiform Mole Chairperson: Ross Berkowitz (USA) 9:00-9:20 S14-1-1 DEVELOPMENTS IN THE MANAGEMENT OF MOLAR PREGNANCY Ross S. Berkowitz1,2), Donald P. Goldstein3) 1) Brigham and Women’s Hospital, United States 2) New England Trophoblastic Disease Center, United States 3) Trophoblastic Tumor Registry, Harvard Medical School, United States 9:20-9:40 S14-1-2 EVALUATION OF THE RISK OF PERSISTENT TROPHOBLASTIC DISEASE AFTER TWIN PREGNANCY WITH ANDROGENETIC COMPLETE MOLE AND COEXISTING NORMAL FETUS Hideo Matsui, Maki Kihara, Hirokazu Usui, Emiri Nakada, Makio Shouzu Department of Reproductive Medicine, Chiba University Graduate School of Medicine, Japan 9:40-10:00 S14-1-3 THE HISTOPATHOLOGY OF HYDATIDIFORM MOLE Michael Wells Acadmic Unit of Pathology, University of Sheffield Medical School, United Kingdom 10:00-10:10 S14-1-4 THE ROLE OF ADJUVANT SURGERY IN THE MANAGEMENT OF GESTATIONAL TROPHOBLASTIC NEOPLASIA (GTN) Ma. Stephanie Fay Samadan Cagayan, MS Magallanes Dept. of Obstetrics and Gynecology and Dept. of Pharmacology and Toxicology University of the Philippines-Philippine General Hospital- 10:10-10:20 S14-1-5 THE ROLE OF SURGERY IN HIGH-RISK GESTATIONAL TROPHOBLASTIC DISEASE (GTD) PATIENTS Sharyn N Lewin1), RA Soslow2), MJ Kim3), NR Abu-Rustum1), Y Sonoda1), CL Brown1), S Mironov4), MS Bains5), R Flores5), DS Chi1), CA Aghajanian3) 1) 2) 3) 4) 5) Gynecology Service, Department of Surgery, Memorial-Sloan Kettering Cancer Center, New York, NY, USA Department of Pathology, Memorial-Sloan Kettering Cancer Center, New York, NY, USA Department of Medicine, Memorial-Sloan Kettering Cancer Center, New York, NY, USA Department of Radiology, Memorial-Sloan Kettering Cancer Center, New York, New York, USA Thoracic Service, Department of Surgery, Memorial-Sloan Kettering Cancer Center, New York, NY, USA 31 14th World Congress on Gestational Trophoblastic Diseases SESSION 14-2: Placental Site Trophoblastic Tumors Chairperson: Laurence Cole (USA) 10:20-10:40 S14-2-1 PLACENTAL SITE TROPHOBLASTIC TUMOR; AN OVERVIEW Joo-Hyun Nam Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Korea 10:40-11:00 S14-2-2 CLINICOPATHOLOGY OF PLACENTAL SITE TROPHOBLASTIC TUMOR Masaharu Fukunaga Department of Pathology, Jikei University Daisan Hospital, Japan 11:00-11:20 S14-2-3 HCG FREE BETA-SUBUNIT AN OUTSTANDING MARKER OF PSTT Laurence A. Cole USA hCG Reference Service, Obstetrics and Gynecology, University of New Mexico, USA 11:20-11:40 S14-2-4 AN ANALYSIS OF THE UK EXPERIENCE OF PLACENTAL SITE TROPHOBLASTIC TUMOURS (PSTT) Michael J Seckl1), Y Nagai2), D Short1), I Lindsay1), NJ Sebire1), A Lim1), R Harvey1), ES Newlands1), B Hancock3), PM Savage1), P Schmid1) 1) Charing Cross Gestational Trophoblastic Disease Centre, Imperial College Hospitals, London, UK 2) Obstetrics and Gynecology Dept, University of the Ryukyus, Okinawa, Japan 3) Sheffield Gestational Trophoblastic Disease Centre, Weston Park Hospital, UK 11:40-12:10 ISSTD Annual General Meeting SESSION 14-3: Imaging Chairperson: Ting-Chang Chang (Taiwan) 12:40-13:00 THE ROLE OF 18F-FLUORODEOXYGLUCOSE POSITRON TOMOGRAPHY IN GESTATIONAL TROPHOBLASTIC DISEASE Ting-Chang Chang1,2), Chyong-Huey Lai1,2), Tzu-Chen Yen1,2), Koon-Kwan Ng1,2), Shih-Ming Jung1,2), Yiu-Tai Li1,3) S14-3-1 EMISSION 1) Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan, Taiwan 2) Chang Gung University College of Medicine, Taoyuan, Taiwan 3) Department of Obstetrics and Gynecology, Kuo General Hospital, Tainan, Taiwan 13:00-13:20 S14-3-2 UPDATE IN IMAGING STUDIES IN GESTATIONAL TROPHOBLASTIC DISEASE. Rafael. Cortes-Charry Trophoblastic Clinic, Department of Obstetrics and Gynecology of Hospital Universitario de Caracas. Universidad Central de Venezuela 13:20-13:40 S14-3-3 IMAGING OF GESTATIONAL TROPHOBLASTIC NEOPLASIA: WHICH MODALITY IS BEST? Adrian K.P. Lim1,2), Michael Seckl2), Philip Savage2), Linda Dayal2), Katherine Hawtin1), Daksha Patel1), Peter Schmid2) 1) Department of Radiology, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom 2) Trophoblastic Disease Unit, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom 32 14th World Congress on Gestational Trophoblastic Diseases 13:40-14:00 S14-3-4 EFFICACY OF 18F-FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY ON DETECTION OF GESTATIONAL TROPHOBLASTIC NEOPLASIA Toshiharu Kamura1), Kimio Ushijima1), Keizo Fujiyoshi1), Masatoshi Ishibashi2) 1) Department of Obstetrics and Gynecology, Kurume University Hospital, Japan 2) Department of Radiology, Kurume University Hospital, Japan 14:00-14:10 S14-3-5 HISTEROSCOPIC FINDINGS POST MOLAR EVACUATION WITH MANUAL ENDOUTERINE ASPIRATION Lina Figueira1), R. Cortes1), Y. Rivas1), A. Morales1), J. Colon2), S. Rebolledo2), A. Lemmo1), C. Santiago1), L. Corredor1) 1) Trophoblastic Clinic of Department of Obstetrics and Gynecology of Hospital Universitario de Caracas, Venezuela 2) Trophoblastic Clinic, Maternidad Concepcion Palacios, Venezuela SESSION 14-4: Trophoblast Differentiation and Fetomaternal Disease Chairperson: Mitsutoshi Iwashita(Japan) 14:10-14:30 S14-4-1 MOLECULAR ANALYSIS FOR INTRAUTERINE GROWTH RESTRICTION (IUGR) Aikou Okamoto1), Hiroko Omi1), Misato Saito1), Rie Kawaguchi1), Takashi Nikaido2), Tadao Tanaka1) 1) Dep. Ob/Gyn Jikei University School Of Medicine, Japan 2) Dep. Pathology Jikei University School Of Medicine, Japan 14:30-14:50 S14-4-2 INVOLVEMENT OF IGF AND DEVELOPMENT AND FUNCTION Mitsutoshi Iwashita IGF-BINDING PROTEIN IN PLACENTAL Dept. of Ob/Gyn, Kyorin University School of Medicine, Japan 14:50-15:10 S14-4-3 HYPOXIA SUPPRESSES EXPRESSION OF SYNCYTIN AND CELL FUSION DURING SYNCYTIALISATION OF HUMAN PLACENTAL BeWo CELLS: IMPLICATIONS FOR IMPAIRED TROPHOBALST SYNCYTIALISATION IN PRE-ECLAMPSIA Yoshiki Kudo Department of Obstetrics and Gynecology, Hiroshima Univeresity, Japan SESSION 14-5: hCG Chairperson: CV Rao (USA) 15:10-15:30 S14-5-1 C.V.Rao PARALLELS AND DIFFERENCES BETWEEN THE hCG ACTIONS DURING PREGNANCY AND GESTATIONAL TROPHOBLASTIC DISEASES University of Louisville Health Sciences Center, United States 33 14th World Congress on Gestational Trophoblastic Diseases 15:30-15:50 S14-5-2 HYPERGLYCOSYLATED hCG (hCG-H) AND THE SOURCE OF PREGNANCY FAILURES Yasushi Sasaki1), Laurence A. Cole2), Donald G. Ladner2), Sarah A. Khanlian2), Atsushi Yanaihara3), Jun Takahashi1), Takashi Okai4) 1) Department of Obstetrics and Gynecology, Showa University Northern Yokohama Hospital, Japan 2) USA hCG Reference Service, Division of Women’s Health Research, Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center 3) Denentoshi Lady’s Clinic, Japan 4) Department of Obstetrics and Gynecology, Showa University School of Medicine, Japan 15:50-16:10 S14-5-3 A FRESH LOOK AT BETA-hCG THROUGH SHEEP MONOCLONAL ANTIBODIES. Paul Davis1), H Mitchell2), W Stewart3), MJ Seckl2), ES Newlands2), M Davis1), T Stephenson1), F Adair1) 1) Mologic, Colworth Science Park, Bedford, UK, 2) Charing Cross GTD Centre, Imperial College Hospitals, London, UK, 3) Dundee GTD Registration Centre, Ninewells Hospital, Dundee, UK 16:10-16:30 S14-5-4 HUMAN PLACENTAL VILLOUS MACROPHAGES AS A FETAL BIOLOGICAL SHIELD FROM MATERNAL CHORIONIC GONADOTROPIN Hidetaka Katabuchi Department of Gyecology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan 16:30-16:50 S14-5-5 BIOLOGY OF HYPERGLYCOSYLATED HCG, THE INVASIVE SIGNAL IN CHORIOCARCINOMA Laurence A.Cole USA hCG Reference Service, Obstetrics and Gynecology, University of New Mexico, USA 16:50- 34 Closing Ceremony 14th World Congress on Gestational Trophoblastic Diseases List of Poster Presentations P-1. MOLECULAR GENETIC ORIGIN ANALYSIS OF CHORIOCARCINOMA Zhao Jun, Xiang Yang Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China. P-2. GENETIC MOLECULAR ANALYSIS OF THE ORIGIN OF CHORIOCARCINOMA Izildhina Maesta1), OC Michelin2), RL Lapate3), LRMG Delmanto1), AR Braga4), KIR Coelho3), CE Paiva2), SR Rogatto5) 1) Department of Gynecology and Obstetrics, Botucatu Medical School, Sao Paulo State University-UNESP, Brazil 2) Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Brazil 3) Post-Graduation Program of Gynecology, Obstetrics and Mastology, Botucatu Medical School, Sao Paulo State University-UNESP, Brazil 4) Department of Patology, Botucatu Medical School, Sao Paulo State University-UNESP, Brazil 5) Department of Urology, Botucatu Medical School, Sao Paulo State University-UNESP, Brazil P-3. UTILITY OF THE P57 PROTEIN (kip2) IN MOLAR DISEASE TO DETERMINE ITS ANDROGENETIC ORIGIN. Rafael. Cortes-Charry1), V. Garcia-Barriola2), L. Figueira1) 1) Trophoblastic Clinic of Department of Obstetrics and Gynecology of Hospital Universitario de Caracas 2) Anatomopathologic Institute. Jose Antonio O.Daly. Universidad Central de Venezuela P-4. ANALYSIS OF SIRH-FAMILY: RETROTRANSPOSON-DERIVED GENES HIGHLY CONSERVED IN MAMMALS M. Naruse1,2), R. Ono1), Y. Sekita1), K. Nakamura3), T. Kohda1), M. Yokoyama4), T. Kaneko-Ishino5), F. Ishino1) 1) 2) 3) 4) 5) P-5. REGULATION OF PLACENTA GROWTH FACTOR (PLGF) IN TROPHOBLAST DERIVED CELLS UNDER HYPOXIC CONDITIONS Fumihito Nishimoto1), Ryoko Minekawa1), Yoko Okamoto2), Asako Miyake1), Aki Isobe4), Toshiya Yamamoto4), Takashi Takeda3), Masahiro Sakata1), Tadashi Kimura 1) 2) 3) 4) P-6. Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, Japan Research Fellow of the Japan Society for the Promotion of Science, Japan Mitsubishi Kagaku Institute of Life Science, Japan Brain Research Institute, Niigata University, Japan School of Health Sciences, Tokai University, Japan Osaka university, Japan Osaka medical center and research institute for maternal and child health, Japan Osaka medical center for cancer and cardiovascular disease, Japan Sakai municipal hospital, Japan EXPRESSION OF PLACENTAL E2-EPF UBIQUITIN CARRIER PROTEIN (UCP) IS DOWN-REGULATED IN PREECLAMPSIA Takamoto Onodera, Hirotaka Nishi, Chinatsu Higuma, Fumitoshi Terauchi, Keiichi Isaka Department of Obstetrics and Gynecology, Tokyo Medical University, Japan P-7. CD98hc ACTIVATES αvβ3 INTEGRIN SIGNALS AT THE HUMAN EMBRYO-MATERNAL INTERFACE N Tamura2), K Sugihara1), M Kabir-Salmani2), S Shiokawa2), K Sakai2), N Kanayama1), M Iwashita2) 1) Departments of Obstetrics and Gynecology, Hamamatus University School of Medicine, Japan 2) Departments of Obstetrics and Gynecology, Kyorin University School of Medicine, Japan 35 14th World Congress on Gestational Trophoblastic Diseases P-8. THE MOLECULAR GENETIC ANALYSIS OF EPITHELIOID TROPHOBLASTIC TUMOR BY USING SHORT TANDEM REPEAT SEQUENCES Satoshi Urabe1), Osamu Samura2), Hisaya Fujiwara1), Hiroshi Miyoshi1), Hiroaki Soma3), Yoshiki Kudo1) 1) Department of Obstetrics and Gynecology, Hiroshima University, Hiroshima, Japan 2) Department of Obstetrics and Gynecology, National Hospital Organization Kure Medical Center, Hiroshima, Japan 3) Department of Obstetrics and Gynecology, Saitama Medical School, Saitama, Japan P-9. LOW RISK GESTATIONAL TROPHOBLASTIC NEOPLASIA: DO PATIENTS NEED TO BE IN HOSPITAL FOR THEIR FIRST CYCLE OF METHOTREXATE? Lucy Carter, Jan Everard, Barry Hancock Trophoblastic Tumour Centre, Weston Park Hospital, Sheffield, UK P-10. AUTOPHAGY, BULK DEGRADATION SYSTEM, PROMOTES EXTRAVILLOUS TROPHOBLAST INVASION IN LOW NUTRIENT, HYPOXIA OR HYPOGLYCEMIC CONDITION Akitoshi Nakashima, Mikiko Tatematsu, Shigeru Saito Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama , Japan P-11. ELEVATION OF SERUM METASTIN CONCENTRATIONS IN HUMAN PREGNANCY Jun Yoshimatsu, Yuichi Furukawa, Junichiro Fukuda, Hisashi Narahara Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Japan P-12. THE EFFECTS OF RELAXIN ON THE INVASIVE POTENTIAL IN CULTURED EARLY HUMAN PLACENTAL EXTRAVILLOUS TROPHOBLASTS. Nobuyuki Maruo, Koji Nakabayashi, Senn Wakahashi, Ai Yata, Takeshi Maruo Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Japan P-13. THE INFLUENCE OF AGE AS A FACTOR IN THE OUTCOME OF GESTATIONAL TROPHOBLASTIC DISEASE. Julia E Palmer1), BW Hancock2), JA Tidy1,2) 1) Dept Gynaecological Oncology, Sheffield Teaching Hospitals NHS trust, Sheffield, UK 2) Sheffield Trophoblastic Disease Centre, Sheffield, UK P-14. DIAGNOSTIC CHALLENGES IN EXTRAUTERINE EPITHELOID TROPHOBLASTIC TUMOURS; A REPORT OF TWO CASES. MC Macdonald1,2), JE Palmer1), BW Hancock2), JA Tidy1) 1) Department of Gynaecological Oncology, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK 2) Sheffield Trophoblastic Disease Centre, Sheffield, UK P-15. HISTONE DEACETYLASE INHIBITORS INDUCE GROWTH INHIBITION, CELL CYCLE ARREST AND APOPTOSIS IN HUMAN CHORIOCARCINOMA CELLS N. Takai, T. Ueda, M. Nishida, K. Nasu, H. Narahara Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan P-16 36 INVASIVE MOLE SHOWING RESISTANCE TO A SINGLE ETOPOSIDE CHEMOTHERAPY Satoru Takeuchi, Keiko Ebisawa, Koji Terasawa, Hiromi Kinoshita, Susumu Minami, Nobuyuki Morioka, Junko Komatu, Hiromitu Matumoto, Tomoaki Kusume Kochi Health Sciences Center, Japan 14th World Congress on Gestational Trophoblastic Diseases P-17. PREDICTING THE NEED FOR ADDITIONAL DOSES AND LINES OF CHEMOTHERAPY IN PATIENTS WITH LOW RISK GESTATIONAL TROPHOBLASTIC NEOPLASIA AFTER INITIAL TREATMENT WITH METHOTREXATE CHEMOTHERAPY WB Growdon1), AJ Wolfberg2), DP Goldstein3), CM Feltmate3), ME Chinchilla3), ES Lieberman3), RS Berkowitz3) 1) Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, USA 2) Department of Obstetrics and Gynecology, New England Medical Center, Boston, USA 3) Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, USA P-18. WHOLE BRAIN IRRADIATION AND HIGH-DOSE MTX EMA/CO FOR CHORIOCARCINOMA WITH BRAIN METASTASES Yutaka Nagai1), Chiaki Yagi1), Kozue Ishimine1), Tsuguhisa Nashiro1), Morihiko Inamine1), Makoto Hirakawa1), Kazuhiko Ogawa2), Takafumi Toita2), Yoshihiko Yoshii3), Sadayuki Murayama2), Yoichi Aoki1) 1) Department of Obstetrics and Gynecology, University of the Ryukyus, Okinawa, Japan 2) Department of Radiology, University of the Ryukyus, Okinawa, Japan 3) Department ot Neurosurgery, University of the Ryukyus, Okinawa, Japan P-19. MIOMETRIAL NODULE RESEMBLING GESTATIONAL TROPHOBLASTIC NEOPLASIA. A CASE REPORT Rafael. Cortes-Charry1), L. Figueira1), V. Garcia-Barriola2), M. Gomez2), A. Balza2), P. Ponce1), M. Dolcet1), M. Fargionni3) 1) Trophoblastic Clinic.Department of Obstetrics and Gynecology of Hospital Universitario de Caracas, Venezuela 2) Anatomopathologic Institute. Jose Antonio O´Daly. Universidad Central de Venezuela, Venezuela 3) General Laboratory of Hospital Universitario de Caracas, Venezuela P-20. MOLAR ECTOPIC PREGNANCY EVOLVING FOR GESTATIONAL TROPHOBLASTIC NEOPLASIA Patricia Daniela Paranhos Batista Soares1,2), Olivia Lucia Nunes Costa1), Izildinha Maesta2), Itana de Matos Pinto e Passos1), Cleber Gomes1), Ludmila Andrade Costa1), Erika Goulart Veloso Ferreira2) 1) Hospital Climerio de Oliveira- UFBA /Brazil 2) Pos-graduated,estudent -UNESP/ BRAZIL P-21. EPITHELIOID TROPHOBLASTIC TUMOUR: A REVIEW OF THE LITERATURE Julia E Palmer1), Macdonald M1), Wells M2), Hancock BW3), Tidy JA1,3) 1) Dept Gynaecological Oncology, Sheffield Teaching Hospitals NHS trus, Sheffield. UK 2) Dept Pathology, Sheffield Teaching Hospitals NHS trust, Sheffield, UK 3) Sheffield Trophoblastic Disease Centre, Sheffield, UK P-22. ACTINOMYCIN-D VERSUS METHOTREXATE-FOLINIC ACID AS THE TREATMENT OF STAGE I, LOW RISK GESTATIONAL TROPHOBLASTIC NEOPLASIA, A RANDOMIZED CONTROLLED TRIAL Ruangsak Lertkhachonsuk, S Tangtrakul, N Israngura, S Wilailak Department of Obstetrics and Gynaecology, Ramathibodi Hospital, Mahidol University, Thailand P-23. TREATMENT OF GESTATIONAL TROPHOBLASTIC NEOPLASIA IN A BRAZILIAN TERTIARY REFERRAL CENTER OC Michelin1), I Maesta2), P Traiman2), LRMG Delmanto2), MA Gomes2), RA Silva3), I Dalben4), M Consonni2) 1) 2) 3) 4) Department of Internal Medicine, Botucatu Medical School- Sao Paulo State University-UNESP, Brazil Department of Gynecology and Obstetrics, Botucatu Medical School- Sao Paulo State University-UNESP, Brazil Botucatu Medical School- Sao Paulo State University-UNESP, Brazil Department of Public Health, Botucatu Medical School- Sao Paulo State University-UNESP, Brazil 37 14th World Congress on Gestational Trophoblastic Diseases P-24. ROLE OF HYSTERECTOMY IN MANAGING GESTATIONAL TROPHOBLASTIC NEOPLASIA John Tidy, J Palmer, J Everard, N Hough, R Coleman, B Hancock Sheffield Trophoblastic Disease Centre, Weston Park Hospital, Sheffield, UK P-25. CASE REPORT OF PRIMARY TUBAL CHORIOCARCINOMA COEXISTENT WITH A NORMAL PREGNANCY Yoshiko Komoto, Haruna Kawaguchi, Kim Yong Hwi, Michiko Kodama, Hirofumi Otsuka, Masahiko Takemura Osaka General Medical Center, Japan P-26. OVARIAN NON-GESTATIONAL CHORIOCARCINOMA ASSOCIATED WITH GONADOBLASTOMA: CASE REPORT AND REVIEW OF LITERATURE Satoshi Ohira, Saori Kondo, Tsutomu Miyamoto, Akiko Horiuchi, Kazuko Itoh, Tanri Shiozawa, Ikuo Konishi Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Japan P-27. PROTEASE PROFILE OF CONDITIONED MEDIUM FROM CHORIOCARCINOMA CELL LINES H Usui, H Matsui, A Mitsuhashi, M Kihara, B Batzorig, E Nakada, M Shozu Reproductive Medicine, Graduate School of Medicine, Chiba University, Japan P-28. SHORTENED CONTROL PROGRAM FOR PATIENTS WITH TRIPLOID HYDATIDIFORM MOLE Isa Niemann1), J Blaakjaer1), L Sunde2) 1) Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark 2) Department of Clinical Genetics, Aarhsu University Hospital, Denmark P-29. EXTRAUTERINE EPITHELIOID TROPHOBLASTIC TUMORS (ETT) PRESENTING AS PRIMARY LUNG CARCINOMAS: MORPHOLOGIC AND IMMUNOHISTOCHEMICAL FEATURES TO RESOLVE A DIAGNOSTIC DILEMMA Sharyn N Lewin1), RA Soslow2), CA Aghajanian3) 1) Gynecology Service, Department of Surgery, Memorial-Sloan Kettering Cancer Center, New York, NY, USA 2) Department of Pathology, Memorial-Sloan Kettering Cancer Center, New York, NY, USA 3) Department of Medicine, Memorial-Sloan Kettering Cancer Center, New York, NY, USA P-30. SEXUAL DYSFUNCTION AS A COMPLICATION OF TREATMENT OF GESTATIONAL TROPHOBLASTIC NEOPLASIA (GTN) Ma. Stephanie Fay Samadan Cagayan Dept. of Obstetrics and Gynecology and Dept. of Pharmacology and Toxicology University of the Philippines-Philippine General Hospital P-31. GESTATIONAL PRIMARY PULMONARY CHORIOCARCINOMA WITH HEPATIC METASTASES: MULTIDISCIPLINARY THERAPY OC Michelin1), I Maesta2), MSS Campos2), RAMB Almeida1), AJM Cataneo3), FG Romeiro1), SR Rogatto4), KIR Coelho5), A Bakonyi Neto3) 1) Oncological Treatment Center of the Department of Internal Medicine, Botucatu Medical School- Sao Paulo State University- UNESP, Brazil 2) Trophoblastic Diseases Center of the Department of Gynecology and Obstetrics, Botucatu Medical School- Sao Paulo State University- UNESP, Brazil 3) Department of Cirurgy and Ortopedy, Botucatu Medical School- Sao Paulo State University- UNESP, Brazil 4) Department of Urology, Botucatu Medical School- Sao Paulo State University- UNESP, Brazil Department of Cirurgy and Ortopedy, Botucatu Medical School- Sao Paulo State University- UNESP, Brazil 5) Department of Pathology, Botucatu Medical School- Sao Paulo State University- UNESP, Brazil 38 14th World Congress on Gestational Trophoblastic Diseases P-32. A CASE OF CHORIOCARCIMOMA BEGAN WITH TUMOR EMBOLUS AND SUDDENLY GOT WORSE Mihyon Song2), S.Yoshida, 1), N. Ushioda1), K. Shimoya1), Y. Oue2), M.Oka2) 1) Kawasaki Medical University department of Obstetrics and Gynecology, Japan 2) Kawasaki Medical School department of medicine division of respiratory medicine, Japan P-33. EPIDEMIOLOGICAL FEATURES OF GTD IN FEMALE POPULATION, IRKUTSK PROVINCE Gladkova Olga1), Pisareva Lubov2), Dvornichenko V.V.1) 1) Regional Oncology Clinic, Irkutsk, Russia 2) Cancer Research Institute, Tomsk, Russia P-34. PROTEOMIC ANALYSIS ON PATHOGENESIS AND INVASIVE MECHANISM OF HYDATIDIFORM MOLE Ma Li, Xiang Yang Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing , China P-35. DIAGNOSIS, TREATMENT AND REHABILITATION OF HYDATIDIFORM MOLE Tengiz Charkviani, Ts. Kharaishvili, T.Tsintsadze, L.Metonidze Gynaecological Clinic, National Oncological Center, Georgia P-36. ENDOMETRIAL SAMPLING IN GESTATIONAL TROPHOBLASTIC DISEASE AFTER SUCTION CURETTAGE Ruangsak Lertkhachonsuk, Surang Treratanachat Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Thailand P-37. COMPLETE MOLE IN A TWIN PREGNANCY. A CASE REPORT Rafael. Cortes-Charry1), A. Castaneda1), L. Figueira1), M. de Gomez2), V. Garcia-Barriola2), J. Navarro2), M. Parilli1), Z. Vivas3), A. Cohen1) 1) Trophoblastic Clinic, Department of Obstetrics and Gynecology of Hospital Universitario de Caracas 2) Anatomopathologic Institute. Jose Antonio O´Daly. Universidad Central de Venezuela 3) Institute of Oncology and Haematology of Universidad Central de Venezuela P-38. DIAGNOSIS OF COEXISTING COMPLETE HYDATIDIFORM MOLE IN IN TWIN PREGNANCY BY p57KIP2 IMMUNOSTAINING M. Kihara, H. Matsui, B. Baasanjav, H. Usui, M. Shozu Department of Reproductive Medicine, Chiba University Graduate school of Medicine, Japan P-39. ELEVATED SERUM SFLT1 LEVEL IN HYDATIDIFORM MOLE Yutaka Osuga, Kaori Koga, Toshiki Tajima, Yasushi Hirota, Chieko Morimoto, Toshio Igarashi, Tomoyuki Fujii, Tetsu Yano, Yuji Taketani Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan P-40. COMPLETE AND PARTIAL HYDATIDIFORM MOLE- DIAGNOSIS AND MANAGEMENT AT A BRAZILIAN TERTIARY CARE CENTER Izildhina Maesta1), LRMG Delmanto1), JC Peracoli1), OC Michelin2), EGV Ferreira3), M Consonni1), FR Gaiotto4), MVC Rudge1) 1) Trophoblastic Diseases Center of the Department of Gynecology and Obstetrics, Botucatu Medical School- Sao Paulo State University- UNESP, Brazil 2) Oncological Treatment Center of the Department of Internal Medicine, Botucatu Medical School- Sao Paulo State University-UNESP, Brazil 3) Post-Graduation Program of Gynecology, Obstetrics and Mastology, Botucatu Medical School- Sao Paulo State University-UNESP, Brazil 4) Graduation Botucatu Medical School- Sao Paulo State University-UNESP, Brazil 39 14th World Congress on Gestational Trophoblastic Diseases P-41. COMPLETE HYDATIDIFORM MOLE WITH COEXISTING DICHORIONIC DIAMNIOTIC TWINS FOLLOWING TESTICULAR SPERM EXTRACTION AND INTRACYTOPLASMIC SPERM INJECTION(TESE-ICSI) M Kudo1), T Yamada1), T Yamada1), Y Ebina1), M Moriwaki1), S Nishi1), T Ohkouchi2), T Matsuda3), N Wake3), H Minakami1), N Sakuragi1) 1) Department of Obstetrics and Gynecology, Hokkaido University, Japan 2) Tabata Hospital, Japan 3) Department of Obstetrics and Gynecology, Kyushu University, Japan P-42. ANTIGEN SPECIFIC T CELL IMMUNE RESPONSE DETECTED BY SKEWED T CELL RECEPTOR USAGE IN NORMAL PLACENTA AND COMPLETE MOLE Zoltan Nagymanyoki1), M.J. Callahan1), M.M. Parast2), V. Fulop3) S.C. Mok1), R.S. Berkowitz1) 1) Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, USA 2) Division of Women’s and Perinatal Pathology, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA 3) Department of Obstetrics and Gynecology, State Health Center, Budapest, Hungary P-43. INCREASED VASCULARIZATION AT THE IMPLANTATION SITE OF PERSISTENT PARTIAL AND COMPLETE MOLAR PREGNANCY Zoltan Nagymanyoki1), M.M. Parast2), V. Fulop3), N. Horowitz1), S.C. Mok1), R.S. Berkowitz1) 1) Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, USA 2) Division of Women’s and Perinatal Pathology, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA 3) Department of Obstetrics and Gynecology, State Health Center, Budapest, Hungary P-44. OVEREXPRESSION OF LAMININ RECEPTOR 1 ON DECIDUAL CELLS IN PARTIAL AND COMPLETE MOLE Zoltan Nagymanyoki1), M.J. Callahan1), M.M. Parast2), R.S. Berkowitz1), S.C. Mok1), V. Fulop3) 1) Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, USA 2) Division of Women’s and Perinatal Pathology, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA 3) Department of Obstetrics and Gynecology, State Health Center, Budapest, Hungary P-45. INCIDENCE OF MOLE IN ONE OF THE WESTERN CITY OF IRAN Seyed Mohammad Hosseinipanah, Soudabeh Aghababaie, Ensieh Mohabikian, Farideh Amini Dept. Anatomy, Medical Faculty, Hamadan University of Medical Sciences.Hamadan-IRAN P-46. EVALUATION OF CYTOTROPHOBLAST IN HUMAN PLACENTA DURING DEVELOPMENT OF HUMAN EMBRYO AND COMPARE IT WITH HYDATIFORM MOLE AND CHORIOCARCINOMA BY AG-NOR TECHNIQUE. Seyed Mohammad Hosseinipanah, Nahid Anvary, Hossein Mahjoub Faezeh Moshayedi Dept. Anatomy, Medical Faculty, Hamadan University of Medical Sciences.Hamadan-IRAN P-47. ASSOCIATION OF THE SER 128 ARG POLYMORPHISM IN NORMAL PREGNANCY AND HYDATIDIFORM MOLE Seyed Mohammad Hosseinipanah, Marzieh Garakhaninejad, Mehrangize Zamani, Mehrdad Hajilooi, Hassein Mahjoub Dept. Anatomy, Medical Faculty, Hamadan University of Medical Sciences.Hamadan-IRAN 40 14th World Congress on Gestational Trophoblastic Diseases P-48. ACCURACY OF MACROSCOPIC DIAGNOSIS IN THE CASE OF HYDATIDIFORM MOLE INCLUDING SMALL HYDOROPIC VILLI - DISCORDANCY FROM GENETIC DIAGNOSIS Eisuke Kaneki1), Hiroaki Kobayashi1), Toshio Hirakawa2), Takao Matsuda3), Hidenori Kato4), Norio Wake1) 1) 2) 3) 4) P-49. Department of Obstetrics and Gynecology, Kyusyu unversity hospital, Japan Sanada clinic, Japan Department of Gynecology, Nisibeppu national hospital, Japan Department of Gynecology, National Hospital Organization Hokkaido Cancer Center, Japan IS HUMAN CHORIONIC GONADOTROPHIN (HCG)-FREE β-SUBUNIT MEASUREMENT A SPECIFIC MARKER OF PLACENTAL SITE TROPHOBLASTIC TUMOURS (PSTT)? Richard Alan Harvey UK Trophoblastic and Screening Service Centre, Charing Cross Hospital, London W6 8RF. P-50. ULTRASONOGRAPHY AS A DIAGNOSTIC TOOL IN INVASIVE MOLE Anwar AD1), Alamsyah M1), Harahap EH2), Martaadisoebrata D1) 1) Department of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University, Hasan Sadikin Hospital Bandung, Indonesia 2) Department of Obstetrics and Gynecology, Pertamina General Hospital Jakarta., Indonesia P-51. A CASE OF MONOAMNIOTIC TWINS WITH TWO YOLK SACS ULTRA- SONOGRAPHICALLY DETECTED IN EARLY FIRST TRIMESTER Tae Mogami1), Miyuki Ogawa1), Aiko Nonaka1), Yuka Ohi1), Aya Kadowaki1), Tetsuya Hasegawa1), Yoshiyuki Nomura1), Keisuke Saito1), Mika Okuda1), Tsuneo Takahashi1), Humiki Hirahara2) 1) Maternity And Neonate Center, Yokohama City University Medical Center 2) Depertment Of Obstetrics And Gynecology, Yokohama City University Hospital P-52. WHAT DO WE THINK OF COMPLETE REMISSION? TWO CASES OF CHOLIOCARCINOMA WITH RESIDUAL MASS AFTER TREATMENT. T. Sakamoto, S. Tanaka, T. Yamazaki, F. Inaba, T. Kamemori, N. Kosaka, K. Yamazawa, I. Fukasawa, N. Inaba Department of Obstetrics and Gynecology, Dokkyo Medical University School of Medicine, Japan P-53. EARLY IDENTIFICATION OF POST-MOLAR TROPHOBLASTIC NEOPLASIA BY NORMAL HUMAN CHORIONIC GONADOTROPIN (β-hCG) REGRESSION CURVE Izildhina Maesta1), LRMG Delmanto1), AR Braga1,4), OC Michelin2), JRS Passos3), FR Gaiotto1), MVC Rudge1) 1) 2) 3) 4) P-54. Department of Gynecology and Obstetrics - Sao Paulo State University, UNESP, Botucatu/SP, Brazil Department of Medical Clinic - Sao Paulo State University, UNESP, Botucatu/SP, Brazil Department of Bioestatistic of Institute of Biociency - Sao Paulo State University, UNESP, Botucatu/SP, Brazil 33th Enfermaria da Santa Casa de Misericordia do Rio de Janeiro, Rio de Janeiro-RJ THE MEASUREMENTS OF SERUM HUMAN CHORIONIC GONADOTROPIN (hCG) IN PATIENTS WITH GESTATIONAL TROPHOBLASTIC NEOPLASIA (GTN) USING WITH TWO DIFFERENT COMMERCIAL hCG KITS Hideo Matsui, Maki Kihara, Hirokazu Usui, Emiri Nakada, Shinnichi Tate, Akira Mitsuhashi, Makio Shozu Department of Reproductive Medicine, Chiba University Graduate School of Medicine, Japan P-55 . RISING hCG-H in PERSISTENT LOW LEVEL hCG Djamhoer Martaadisoebrata Dept of Obstetrics and Gynecology, Hasan Sadikin Hospital, Indonesia 41 14th World Congress on Gestational Trophoblastic Diseases P-56. CLINICAL APPLICATIONS OF HCG-MRNA QUANTIFICATION IN CHORIOCARCINOMA Kentaro Yamasaki, Kiyonori Miura, Shoko Miura, Shingo Moriyama, Haruka Gunjigake, Hideaki Masuzaki Department of Obstetrics and Gynecology, School of Medicine, Nagasaki University, Japan P-57. AMNIOTIC STEM CELLS FORM SPHEROID N Yoneda1,2), M Okabe1), A Toda1), O Higuchi1), M Nogami1), R Nishiyama2), M Ito2), A Shiozaki2), T Yoshida1), S Saito2), T Nikaido1) 1) Department of Regenerative Medicine, University of Toyama Graduate School of medicine and Pharmaceutical Sciences, Japan 2) Department of Obstetrics and Gynecology, University of Toyama Graduate School of medicine and Pharmaceutical Sciences, Japan P-58. THE ROLE OF THORACOTOMY IN GESTATIONAL TROPHOBLASTIC DISEASE Evelyn L. Fleming, L. Garrett, M. Callahan, S. Ghosh, N. Nevadunsky, D. Goldstein, R. Berkowitz The New England Trophoblastic Disease Center, Brigham and Womens Hospital, Harvard University, USA. P-59. A CASE OF PLACENTAL MESENCHYMAL DYSPLASIA Sreedevi Venugopal1), P. K. Sekharan1), S. Vinayachandran1), Smitha D Couth1), O. Rasheeda Beghum1), C. H. Mini1), Meera Pavithran1) Medical College, Calicut, Kerala, India P-60. THE FETAL GROWTH RESTRICTION CAUSED BY MATERNAL UNDERNUTRITION IS AMELIORATED BY BRANCHED-CHAIN AMINO ACIDS-SUPPLEMENTED DIET Haruta Mogami1), Shigeo Yura1), Hiroaki Itoh2), Tsuyoshi Fujii1), Makoto Kawamura1), Norimasa Sagawa3), Shingo Fujii4) 1) 2) 3) 4) P-61. Kyoto University Graduate School of Medicine, Japan Osaka Medical Center, Japan Mie University Graduate School of Medicine, Japan Kyoto Medical Center, Japan DIFFERENT CHANGES IN RESISTANCE INDEX BETWEEN UTERINE ARTERY AND UTERINE RADIAL ARTERY DURING EARLY PREGNANCY Isao Tamura, Hiroshi Tamura, Ken Taniguchi, Ryo Maekawa, Hiromi Asada, Toshiaki Taketani, Aki Matsuoka, Yoshiaki Yamagata, Norihiro Sugino Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Japan P-62. PLACENTAL REGULATION OF MATERNAL MELATONIN PRODUCTION IN PREGNANT RATS Tosiaki Taketani, Hiroshi Tamura, Isao Tamura, Ken Taniguchi, Ryo Maekawa, Hiromi Asada, Aki Matsuoka, Yoshiaki Yamagata, Norihiro Sugino Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Japan P-63. SERIOUS BIPOLAR DEPRESSION AMALGAMATION PREGNANCY WITH SEVERE IUGR WOULD BE CAUSED BY PLACENTA THROMBUS FORMATION AFTER ECT REPEATING ITSELF Takashi Yamada1), Rintaro Sawa1), Hiroko Abe1), Fumi Kikuti1), Katsuya Mine1), Gen Ishikawa1), Tetsuya Ichimiya2), Yoshiro Okubo2), Toshiyuki Takeshita1) 1) Department of Obstetrics and Gynecology, Nippon Medical School, Japan 2) Department of Neuropsychiatry, Nippon Medical School, Japan 42 14th World Congress on Gestational Trophoblastic Diseases P-64. RESIDUAL OF EXTRAEMBRYONIC COELOM CYST: CASE REPORT Seiji Sumigama, Hiromi Hayakawa, Fumitaka Kawachi, Masae Hironaka, Akiko Morimitsu, Yukio Mano, Nanako Sato, Masako Araki, Fumitaka Kikkawa Nagoya University Graduate School of Medicine, Department of Obstetrics and Gynecology, Japan P-65. SUBCELLULAR DISTRIBUTION OF IGG AND ALBUMIN IN THE FIRST-TRIMESTER HUMAN PLACENTA AS REVEALED BY ULTRAHIGH-RESOLUTION IMMUNOFLURECENCE MICROSCOPY Gen Ishikawa1), Miki Mori2), Shan-Shun Luo2), Tomoko Ishikawa2), Takuya Mishima2), Toshiyuki Takeshita1), Toshihiro Takizawa2) 1) Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan 2) Department of Molecular Anatomy and Medicine, Nippon Medical School, Tokyo, Japan P-66. EXPRESSION OF FC GAMMA RECEPTORS ON HUMAN PLACENTAL HOFBAUER CELLS Toshihiro Takizawa1), Gotaro Kurasawa1), Miki Mori1), Gen Ishikawa2), Osamu Ishibashi1), Takuya Mishima1), Tomoko Ishikawa1), Shan-Shun Luo1), Takami Takizawa1), Tadashi Goto1), Toshiyuki Takeshita2) 1) Department of Molecular Anatomy and Medicine, Nippon Medical School, Tokyo, Japan 2) Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan 43