ICONZ 221948 - Annex I - Avia-GIS

Transcription

SEVENTH FRAMEWORK PROGRAMME
THEME 2
Food, Agriculture and Fisheries, and Biotechnology
Call KBBE-2007-1-3-09
Grant agreement for:
Large Collaborative Project
Specific international co-operation action (SICA)
Annex I – “Description of Work”
Project acronym: ICONZ
Project full title:
Integrated control of neglected zoonoses: improving human health and animal
production through scientific innovation and public engagement
Grant agreement no.: 221948
Date of preparation of Annex I: 10 September 2008
Revised Annex I: 20 November 2008
Date of approval of Annex I by Commission:
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Table of Contents
Table of Contents ............................................................................................................................ii
PART A
...................................................................................................................................iv
A1.
Budget breakdown and project summary...................................................................iv
A1.1.
Budget breakdown form (copy of A3.2 form of the GPFs). ......................................iv
A1.2.
Project summary form (copy of A1 form of the GPFs). .............................................v
A1.3.
Beneficiaries...............................................................................................................vi
PART B
....................................................................................................................................1
B1.
Concept and objectives, progress beyond state-of-the-art, S/T methodology
and work plan.............................................................................................................1
B1.1.
Concept and objectives................................................................................................1
B1.1(i)
Concept................................................................................................................1
B1.1(ii)
Objectives............................................................................................................3
Figure 1: Overview of ICONZ Activities and Work Packages..................................................4
B1.2.
Progress beyond the state-of-the-art............................................................................8
B1.2(i)
Constraints to neglected zoonoses control ..........................................................8
B1.2(ii)
Mapping research ................................................................................................8
B1.2(iii)
Disease epidemiology and distribution ...............................................................9
B1.2(iv)
Disease burdens...................................................................................................9
B1.2(v)
Case studies .......................................................................................................10
B1.2(vi)
Disease control tools .........................................................................................10
B1.2(vii) Implementation measures..................................................................................12
B1.2(viii) Policy making....................................................................................................12
B1.2(ix)
Role of women ..................................................................................................13
B1.3.
Scientific and technological methodology and associated work plans. ....................14
B1.3(i)
Overall strategy of the work plan ......................................................................14
B1.3(ii)
Timing of the different wps and components....................................................21
B1.3(iii)
Work package list / overview............................................................................22
B1.3(iv)
Deliverables list.................................................................................................23
B1.3(v)
Work package descriptions ...............................................................................27
B1.3(vi)
Efforts for the full duration of the project .........................................................39
B1.3(vii) List of milestones and planning of reviews.......................................................42
B2.
Implementation .........................................................................................................45
B2.1.
Management structure and procedures......................................................................45
B2.2.
Beneficiaries..............................................................................................................47
Partner 1: University of Edinburgh (UEDIN), UK ...............................................................48
Partner 2: Department of Animal Health, Institute of Tropical Medicine (ITM),
Antwerp, Belgium .............................................................................................49
Partner 3: Department of Veterinary Pathobiology, Faculty of Life Sciences,
University of Copenhagen (UCPH), Denmark .................................................50
Partner 4: Agence Française de Sécurité Sanitaire des Aliments (AFSSA) Laboratory
of Research on Rabies and Wildlife diseases (LERRPAS), France..................51
Partner 5: Department of Parasitology (ISPBL) - University Claude Bernard Lyon 1
(UCBL), France.................................................................................................52
Partner 6: National Veterinary Reference Laboratory on Tuberculosis,
Friedrich-Loeffler-Institute (FLI), Federal Research Institute for Animal
Health, Jena, Germany ......................................................................................53
Partner 7: Life and Health Sciences Research Institute (ICVS) School of Health Sciences,
University of Minho (UMINHO), Braga, Portugal...........................................54
Partner 8: Department of Microbiology, University of Navarra (UNAV), Spain.................55
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Partner 9: Karolinska Institutet (KI) / Swedish Institute for Infectious Disease Control,
Sweden ..............................................................................................................56
Partner 10: Swiss Tropical Institute, Basel (STI), Switzerland.............................................57
Partner 11: National Centre for Zoonosis Research (NCZR), University of Liverpool
(ULIV), UK .......................................................................................................58
Partner 12: Central Veterinary Laboratory (LCV), Bamako, Mali .......................................59
Partner 13: Institut Agronomique et Vétérinaire Hassan II (IAVH2), Rabat, Morocco .......60
Partner 14: Veterinary Faculty, Eduardo Mondlane University (UEM), Maputo,
Mozambique......................................................................................................61
Partner 15: Brucellosis Research laboratory, National Veterinary Research Institute
(NVRI Vom), Vom, Nigeria .............................................................................62
Partner 16: Makerere University Faculty of Veterinary Medicine (MAK), Uganda ............63
Partner 17: South African Centre for Epidemiological Modelling and Analysis,
Faculty of Science, Stellenbosch University (SU), South Africa .....................64
Partner 18: Department of Veterinary Medicine and Public Health,
Faculty of Veterinary Medicine, Sokoine University of Agriculture,
Morogoro, Tanzania ..........................................................................................65
Partner 19: Department of Paraclinical Studies, School of Veterinary Medicine,
University of Zambia, Lusaka (UNZA), Zambia ..............................................66
Partner 20: Agriculture and Veterinary Information and Analysis (Avia-GIS), Belgium ....67
Partner 21: Lab901, Edinburgh, UK .....................................................................................68
Partner 22: International Livestock Research Institute (ILRI), Kenya .................................69
B2.3.
Consortium as a whole ..............................................................................................70
B2.4.
Resources to be committed .......................................................................................72
B3.
Potential Impact.........................................................................................................75
B3.1.
Expected impacts listed in the work programmes.....................................................75
B3.1(i)
Contribution towards the expected impacts listed in the work programme ......75
B3.1(ii)
Steps that will be needed to bring about these impacts.....................................76
B3.1(iii)
Why this contribution requires a European approach .......................................77
B3.1(iv)
How account is taken of other national or international research activities......78
B3.1(v)
Assumptions and external factors that may determine whether the impacts
will be achieved.................................................................................................78
B3.2.
Dissemination and/or exploitation of project results, and management of
intellectual property...................................................................................................78
B4.
Ethical Issues.............................................................................................................81
Issues raised in the ethical issues review report ........................................................................82
Informed consent...................................................................................................................82
Privacy
...........................................................................................................................83
Research on Animals.............................................................................................................84
Research involving developing countries .............................................................................84
B5.
Gender Issues ............................................................................................................85
B5.1.
Actions related to the project consortium .................................................................85
B5.2.
Actions aimed at a wider public................................................................................85
B5.2(i)
events organised in schools or universities .......................................................85
B5.2(ii)
implications for women in icpcs .......................................................................85
Appendix I: References.................................................................................................................86
References - General .................................................................................................................86
References - Ethical Issues........................................................................................................87
Appendix II: List of abbreviations ................................................................................................88
Appendix III: Detailed Gantt Chart...............................................................................................89
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FP7-KBBE-2007-1-3-09
ICONZ: 221948
PART A
A1. Budget breakdown and project summary
A1.1. Budget breakdown form (copy of A3.2 form of the GPFs).
Participant
number in this
project9
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
TOTAL
Estimated eligible costs (whole duration of the project)
Participant short
name
UEDIN
ITM
UCPH
AFSSA
UCBL
FLI
UMINHO
UNAV
KI
STI
ULIV
LCV
IAVH2
UEM
NVRI-VOM
MAK
SU
SUA
UNZA
AVIA-GIS
Lab901
ILRI
RTD / Innovation
(A)
107,606.00
507,771.00
0.00
201,009.00
107,606.00
107,606.00
107,606.00
201,008.00
107,606.00
507,771.00
357,600.00
186,000.00
187,833.00
192,000.00
186,000.00
206,666.00
207,356.00
192,000.00
186,000.00
317,188.00
50,780.00
88,878.00
4,313,890.00
iv
Demonstration
(B)
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
Total receipts
Management (C)
564,100.00
14,000.00
14,000.00
14,000.00
0.00
0.00
0.00
14,000.00
0.00
14,000.00
14,000.00
0.00
0.00
14,000.00
0.00
14,000.00
0.00
14,000.00
0.00
14,000.00
0.00
0.00
704,100.00
Other (D)
518,415.00
0.00
512,086.00
63,446.00
63,340.00
63,340.00
63,340.00
63,446.00
63,340.00
0.00
0.00
60,666.00
59,616.00
60,000.00
60,666.00
96,000.00
95,214.00
60,000.00
60,666.00
158,563.00
0.00
107,564.00
2,229,708.00
Total A+B+C+D
1,190,121.00
521,771.00
526,086.00
278,455.00
170,946.00
170,946.00
170,946.00
278,454.00
170,946.00
521,771.00
371,600.00
246,666.00
247,449.00
266,000.00
246,666.00
316,666.00
302,570.00
266,000.00
246,666.00
489,751.00
50,780.00
196,442.00
7,247,698.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
Requested EC
contribution
1,163,219.00
394,828.00
526,086.00
228,202.00
144,044.00
144,044.00
144,044.00
228,202.00
144,044.00
394,828.00
282,200.00
200,166.00
200,490.00
218,000.00
200,166.00
264,999.00
250,731.00
218,000.00
200,166.00
410,454.00
38,085.00
0.00
5,994,998.00
FP7-KBBE-2007-1-3-09
ICONZ: 221948
A1.2. Project summary form (copy of A1 form of the GPFs).
General information
Project title 3
Starting date 4
Duration in months 5
Call (part) identifier 6
Activity code(s) most
relevant to your topic 7
Free keywords 8
Integrated control of neglected zoonoses: improving human health and animal
production through scientific innovation and public engagement
01/04/2009
60
FP7-KBBE-2007-2A
KBBE-2007-1-3-09:
Neglected zoonoses in
developing countries:
integrated approach for the
improvement of their
control in animals
anthrax brucellosis tuberculosis cysticercosis
echinococcosis leishmaniasis rabies trypanosomiasis
zoonosis
Abstract 9 (max. 2000 char.)
This project aims at Improving Human Health and Animal Production in developing countries through Integrated
Control of Neglected Zoonoses in animals, based on Scientific Innovation and Public Engagement. Neglected
zoonoses, such as anthrax, rabies, brucellosis, bovine TB, zoonotic trypanosomiasis, echinococcosis, cysticercosis
and leishmaniasis, are major causes of ill-health in developing countries in Africa, Asia and Latin America. Production
animals and companion animals of significant societal value act as reservoirs for transmission to man, and the
burden of these diseases on affected communities is compounded by the adverse effects many diseases have on the
productivity of livestock and hence the livelihoods of the poor. Control of these diseases in animals represents an
opportunity to address the constraints they pose to both human health and animal productivity, thereby contributing to
poverty reduction and the MDGs. Effective control in animals will require scientific innovation to identify and (where
necessary) develop tools for diagnosis, for quantification of disease burdens, and for control. Public engagement at
all stakeholder levels will be needed to ensure that strategies are appropriate for use in affected communities and are
adopted within the policy framework of affected countries. The project will: (i) map and review research activities at a
global level, (ii) survey and assess the burden of zoonoses in communities, (iii) improve or develop disease control
tools as appropriate for conditions in affected countries, with private sector inputs where appropriate, (iv) develop
cost-effective control and prevention strategies taking into account economic, sociological and cultural factors as well
as traditional knowledge, (v) build capacity in ICPCs through technology transfer and training and (vi) empower
communities and policy makers to utilise control and prevention strategies appropriately and effectively.
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A1.3. Beneficiaries
List of beneficiaries:
Beneficiary
Beneficiary name
number
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
Beneficiary
short name
Country
Date enter Date exit
project
project
UK
(Scotland)
Month 1
Month 60
ITM
Belgium
Month 1
Month 60
UCPH
Denmark
Month 1
Month 60
AFFSA
France
Month 1
Month 60
UCBL
France
Month 1
Month 60
FLI
Germany
Month 1
Month 60
UMINHO
UNAV
KI
STI
ULIV
Portugal
Spain
Sweden
Switzerland
UK
Month 1
Month 1
Month 1
Month 1
Month 1
Month 60
Month 60
Month 60
Month 60
Month 60
LCV
Mali
Month 1
Month 60
IAVH2
Morocco
Month 1
Month 60
UEM
Mozambique Month 1
Month 60
NVRI-VOM
Nigeria
Month 1
Month 60
MAK
Uganda
Month 1
Month 60
SU
South Africa
Month 1
Month 60
SUA
Tanzania
Month 1
Month 60
UNZA
AVIA
Zambia
Belgium
UK
International
Organisation
Month 1
Month 1
Month 1
Month 60
Month 60
Month 60
Month 1
Month 60
University of Edinburgh UEDIN
Institute of Tropical
Medicine
University of
Copenhagen
Agence Française de
Sécurité Sanitaire des
Aliments
Université Claude
Bernard Lyon 1
Friedrich-LoefflerInstitut, Federal
Research Institute for
Animal Health
University of Minho
University of Navarra
Karolinska Institutet
Swiss Tropical Institute
University of Liverpool
Laboratoire Central
Vétérinaire
Institut Agronomique et
Vétérinaire Hassan II
Eduardo Mondlane
University
National Veterinary
Research Institute, Vom
Makerere University
SACEMA, Stellenbosch
University
Sokoine University of
Agriculture
University of Zambia
AVIA-GIS
Lab 901
International Livestock
Research Institute
ILRI
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FP7-KBBE-2007-1-3-09
Part B
ICONZ
PART B
B1. Concept and objectives, progress beyond state-of-theart, S/T methodology and work plan
B1.1. Concept and objectives
B1.1(i) CONCEPT
Neglected zoonoses are mainly associated with people living in close proximity to domestic
or wild animals. They are usually endemic and found throughout the developing world where
the conditions for their maintenance and spread exist. Unlike emerging zoonoses, which
attract considerable international attention, the endemic zoonoses are often neglected resulting
in considerable health problems. These endemic and occasionally epidemic zoonoses
continually affect poor livestock keepers in marginalized communities.
Neglected zoonoses, such as anthrax, rabies, brucellosis, bovine TB, zoonotic
trypanosomiasis, echinococcosis, cysticercosis and leishmaniasis, are major causes of illhealth in the poorest communities in developing countries in Africa, Latin America and Asia.
Because they also affect livestock, causing lowered productivity or death, they not only attack
people’s health, but also their livelihoods. The situation is further complicated in that both
production and companion animals of significant societal value may act as reservoirs from
which these diseases are transmitted to man.
These diseases are the focus of this proposal. The overall concept is based on the need to
develop and promote integrated controls for neglected zoonoses in developing countries.
Integrated control covers both concerted efforts against several neglected zoonoses (and
possibly non-zoonotic infections) in affected communities, and an approach targeted at both
transmission of infection and animal reservoirs. In the context of the neglected zoonoses
agenda, combining integrated, inter-programmatic, and inter-sectoral approaches to reach
marginalized populations or geographic areas, based on stratification of risks, should provide
significant added value (Holveck, et al., 2007). The result of more effective control of
neglected zoonoses in animals based on scientific innovation and public engagement would
be improved human health and animal production.
This concept is supported by a number of recent reports from international organisations. The
report of the joint World Health Organisation (WHO) and DFID UK Animal Health
Programme meeting held in Geneva in September 2005 focused on endemic zoonoses. WHO
has drawn attention to the relationship between poverty and the emergence or re-emergence of
zoonotic diseases, which are largely neglected. The European Technology Platform for
Global Animal Health (ETPGAH) also recognised the importance of neglected zoonoses and
identified the need to facilitate and accelerate the development and distribution of effective
tools for controlling animal diseases of major importance to both Europe and the rest of the
world.
The poor in least developed countries bear a disproportionately high burden of disease
through reasons of access to and affordability of healthcare, and vulnerability. The burden of
zoonoses falls especially heavily on poor people because (i) they are at greater risk of
contracting these diseases because of the strong association between poverty and living
closely with the animal reservoirs of disease, (ii) they are less likely to receive effective
treatment, mainly because of the difficulties in diagnosis, and (iii) they suffer from the dual
burden of disease both in humans and the animals on which they depend for their livelihoods.
The proposed project, Integrated Control of Neglected Zoonoses (ICONZ), will focus initially
on the neglected zoonoses found in Africa for a number of reasons. An overwhelming body of
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FP7-KBBE-2007-1-3-09
Part B
ICONZ
evidence shows that the greatest impacts attainable by the Project will be in Africa,
particularly sub-Saharan African countries. The call states that ‘the project will contribute to
the improvement of animal and human health and hence the livelihoods of the poorest
communities. It will contribute to the reduction of poverty and the Millennium Development
Goals’. The Economic and Social Council of the United Nations (2003) observed that 35 of
the least developed countries are in Africa, and the benefits and impacts accruing from the
control of zoonotic diseases in developing countries will be greatest in this region.
There is now substantial evidence to confirm that intervening to control zoonoses is highly
cost-effective when considered from a societal point of view, and that targeted interventions
have an enormous potential for poverty alleviation. Moreover, Africa is the only continent
affected by all eight of the zoonoses targeted by the FP7 call. However disease control tools
and disease control and prevention strategies developed and improved by the proposed project
will be applicable to the wider developing world, particularly south Asia and Latin America.
The control of these diseases in animals represents an opportunity to address the constraints
they pose to both human health and animal productivity, thereby contributing to poverty
reduction and achieving the Millennium Development Goals. Effective disease management
can impact on health (MDG 6,2,5; and build wealth (MDG1) impacting on education (MDG
2, 3) through building global partnerships (MDG 8). This proposal recognises that effective
control in animals will require scientific innovation and investigation to i) identify, and where
necessary develop, tools for diagnosis, ii) quantify the burden of disease and iii) develop
measures for integrated control. Public engagement at all stakeholder levels is identified as
critical to ensure that these strategies are appropriate for use in affected communities and that
they are accepted and adopted within the policy framework of affected countries.
The concept is to develop a matrix consisting of the 8 diseases on the one hand and on the
other hand the broader requirements of gap analysis, development of control strategies,
analysis of burdens, technology transfer and communications. Each of a number of work
packages will handle a broad generic concept within which each of the 8 diseases will be
covered.
There is much demand for capacity building in the developing world which is widely
recognised by international organisations. This proposal aims to help meet this demand by
building on existing networks and linkages. Research establishments in Europe and the
developing ICPCs will be involved in the project. The mapping of infrastructure, facilities and
activities will generate a better understanding of the resources available to the partnership.
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Part B
ICONZ
B1.1(ii) OBJECTIVES
ICONZ will be carried out over 5 years and has a number of complementary strands for
addressing the main objectives of the FP7-KBBE-2007-1-3-09 topic. The overall strategic
objective of ICONZ is to improve human and animal health, alleviate poverty and contribute
to the millennium goals. To achieve this, a number of actions are required to ensure that the
current position regarding neglected zoonoses in terms of the burdens on communities and
relevant research are understood. Building on this knowledge, new technologies and research
outcomes should be utilised to improve the control of neglected zoonoses by developing
improved tools and identifying the situations in which they can be employed. All of this must
be communicated to stakeholder, and particularly policy advisors of affected countries.
The proposal has been designed with interrelated work packages to address the requirements
of the FP7 call. The objectives are:1. To map global research into neglected zoonoses;
2. To obtain knowledge and information on the neglected zoonoses in terms of disease,
epidemiology and burdens. This requires systematic collection of data on disease
prevalence supported by studies to estimate their dual burden on people and on
livestock, quantify under-reporting and identify communities and groups at risk;
3. To improve and develop control tools for the neglected zoonoses by identifying gaps and
investing in the development of new tools needed to effectively control these diseases;
4. To improve and develop integrated control and prevention strategies promoting the
concept of ‘one health’. This involves dealing with health problems in people, their
livestock and other domestic and wild animals they depend on for their livelihoods
through the development of integrated ‘intervention packages’;
5. To promote intersectoral collaboration in the control of neglected zoonoses;
6. To empower women in decision making related to control of neglected zoonoses in
livestock through messaging cognisant of traditional knowledge and appropriate to the
economic, sociological and cultural contexts of affected communities;
7. To transfer technologies and build capacity in developing countries to control neglected
zoonoses; and
8. To ensure maximum benefit from the project by a pro-active programme of
dissemination aimed at all relevant stakeholders especially by raising the profile of the
neglected zoonotic diseases both internationally and within affected countries.
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Part B
ICONZ
Figure 1: Overview of ICONZ Activities and Work Packages
The management and coordination (WP1) of the ICONZ work packages will be essential for
successful delivery of the objectives.
WP1 Project Management & Coordination
•
•
•
Management: administration, meetings and feedback
Networking and liaison within the consortium
Promote international partnerships
WP2 Mapping global neglected zoonoses research
•
•
•
Gain global overview and produce database
Map research activities and identify gaps
Promote networking outside consortium
WP3 Knowledge and information
on neglected zoonoses
WP4 Disease control tools
• Review diagnostic tools
• Review control and prevention tools
• Review messaging and awareness
tools
• Identify research gaps
• Validate new and improved tools
• Estimate incidence and
prevalence
• Assess under-reporting
• Map disease risk (GIS)
• Assess total societal burden of NZs
Control and prevention strategies:
integrated intervention packages
WP5 Bacterial
zoonoses cluster
• Anthrax
• Bovine
tuberculosis
• Brucellosis
WP6 Small ruminant/
dog cluster
• Cystic
echinococcosis
• Leishmaniasis
• Rabies
WP7 Pig-associated
disease cluster
• Cysticercosis
• Neurocysticercosis
• Taeniosis
WP8 Vector-borne
disease cluster
• Zoonotic
trypanosomiasis
• Tick-borne animal
diseases
• Malaria in some
areas
Review of strategies, site-specific studies, technical validation
Overarching support packages
WP9 Socio-economic and
Institutional
Aspects
• Cost-effectiveness
• Medical-veterinary
collaboration
• Cost sharing
• Advocacy
WP10 Cultural Aspects and
Messaging
• Gender issues
• Traditional knowledge
• Appropriate
interventions
• Appropriate messages
in all media
WP11 Technology Transfer and Training
• Support build up of diagnostic and control capacities and facilities
• Train scientists, doctors, veterinarians and others working on NZ control
• Produce community training packages for livestock keepers and
householders, especially women
WP12 Communication and Dissemination
•
•
•
•
Secure government commitment to NZ control
Ensure effective communication among stakeholders
Promote establishment and support activities of Scientific Advisory Committee for NZ
Make available information on all aspects of NZ covered by project
4
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FP7-KBBE-2007-1-3-09
Part B
ICONZ
The scientific and technical objectives for each work package are briefly described below.
Full details for each work package will be included in section B1.3(iii).
WP1 PROJECT MANAGEMENT AND COORDINATION
The main objective of this work package is:1. To ensure the effective management of the project so that it meets its objectives
This WP has been designed to provide management necessary to ensure effective integration
and coordination of the collaboration. The nature of this proposal with a wide range of
participants places a strong emphasis on stakeholder input and horizontal interactions with
other groups involved in research, development and delivery of new tools and strategies.
WP2 MAPPING GLOBAL RESEARCH ON NEGLECTED ZOONOSES.
The main objectives of this work package are:1. To provide a clear picture of current research into diagnosis, burdens and control of
neglected zoonoses
2. To identify significant research gaps in the above areas
3. To encourage networking among all key researchers on the neglected zoonoses targeted
in this call
It is important to develop this overview of the situation with respect to the neglected zoonoses
(NZ) to ensure resources are correctly focused and duplication of effort avoided. It is equally
important to ensure that networking is developed particularly to include researchers in the
developing international cooperation partner countries (ICPCs).
WP3
KNOWLEDGE & INFORMATION ON NEGLECTED ZOONOSES
One of the problems with the NZ is the presence of gaps in current knowledge about many
aspects of each disease. This is especially true when attempting to assess the burdens of the
diseases. Surveillance for these diseases is important in determining the prevalence and
distribution to evaluate the burdens they impose on individuals, groups and countries. The
objectives of this work package are:
1. To provide essential epidemiological and sociological information on each of the
neglected zoonoses
2. To develop a standardized and accepted methodology for quantifying the burdens and
costs of neglected zoonoses
3. To utilise these methodologies to quantify the overall burden of neglected zoonoses
targeted in the call in humans and animals
WP4
IMPROVE AND DEVELOP DISEASE CONTROL TOOLS
In order to meet the objectives of this work package the effectiveness and availability of
existing tools for the control of NZ will be assessed. A range of tools are available but new
technologies should enable the development of new and more effective tools. Any new or
improved tools must be validated and demonstrated to the authorities who will ultimately use
these tools for the control of NZ. The work package has the following objectives:
1. To identify currently available tools in relation to diagnosis, vaccination, treatment and
policy for each of the neglected zoonoses listed in the call
2. To provide a detailed assessment of gaps in the disease control tools available
3. To facilitate the development of new and improved tools
4. To demonstrate the scientific validity of control tools for neglected zoonoses
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WPS5 –8 IMPROVE AND DEVELOP CONTROL AND PREVENTION STRATEGIES THROUGH
INTEGRATED INTERVENTION PACKAGES FOR CLUSTERS OF NEGLECTED ZOONOSES
It is imperative to develop control and prevention strategies which are effective and
appropriate for the country and communities concerned. As stated in the Food, Agriculture
and Fisheries, and Biotechnology Work Programme, “a major impact is expected by tackling
these zoonoses as a group”. Hence the emphasis of ICONZ will be on control and prevention
through integrated ‘packages’ of interventions targeted at groups or ‘clusters’ of related NZ.
The clusters of NZ to be addressed by ICONZ in specific categories of animals or animal
production systems are:

WP5 NEGLECTED BACTERIAL ZOONOSES CLUSTER (anthrax,
bovine tuberculosis & brucellosis),
WP6 NEGLECTED SMALL RUMINANT / DOG-ASSOCIATED ZOONOSIS CLUSTER (cystic
echinococcosis,
leishmaniasis & rabies),

WP7 NEGLECTED PIG-ASSOCIATED PARASITIC ZOONOSIS CLUSTER
(porcine cysticercosis,
neurocysticercosis & taeniosis) and

WP8 NEGLECTED VECTOR-BORNE ZOONOSIS CLUSTER (zoonotic trypanosomiasis, tick-borne animal
diseases & malaria [in some areas]).
The objectives for these four work packages are generically:
1. To improve and develop prevention and control strategies for clusters of neglected
zoonoses in endemic developing countries of Africa, taking into account economic,
sociological and cultural aspects related to the diseases as well as traditional
knowledge
2. To develop cost-effective disease control strategies for clusters of neglected zoonoses
3. To develop integrated disease control packages for clusters of neglected zoonoses
4. To provide information for incorporation under WP11 into materials to be used in
training and capacity building activities
5. To provide information for advocacy, and strategic options for control and prevention
of neglected zoonoses to be disseminated under WP12 to governments, technical
assistance agencies (e.g. FAO, WHO, etc) and donor bodies
Two further work packages will provide overarching support measures on socioeconomic and
institutional aspects (WP9) and cultural aspects, gender issues, traditional knowledge and
messaging (WP10) in the control of NZ in complementarity to WP5–8.
WP9
SOCIOECONOMIC & INSTITUTIONAL ASPECTS OF THE CONTROL OF NEGLECTED
ZOONOSES
The control and prevention strategies must be demonstrated to be cost effective having
assessed the various control options. Intersectoral institutional collaboration is important here
since control costs in animals accrue benefits in both human and animal health. The
objectives for this work package are:
1. To collect existing information and data on the cost-effectiveness of various control
strategies for each of the neglected zoonoses under consideration by ICONZ
2. To set up activities with ICPC participants in ICONZ to fill knowledge gaps on costeffectiveness of control strategies for neglected zoonoses
3. To analyse the cost-effectiveness of integrated intervention packages being tested and
validated under WPs 5-8 for each of the neglected zoonoses clusters
4. To formulate recommendations as to appropriate medical/veterinary structures, liaison
and cost-sharing for the effective control of NZs
5. To provide overarching support to other WPs, especially WPs5–8 & WP10, in socioeconomic and institutional matters
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6. To harmonise with WP3 & WPs5-10 in providing training materials to be taken up by
WP11 and to provide information for advocacy to be disseminated by WP12
WP10 CULTURAL ASPECTS, GENDER ISSUES, TRADITIONAL KNOWLEDGE AND MESSAGING IN
THE CONTROL OF NEGLECTED ZOONOSES
ICONZ will develop control and prevention strategies taking into account economic,
sociological and cultural aspects related to the diseases as well as traditional knowledge, in
accordance with the Work Programme. Accordingly, the attribution of a major role to
women, both in the veterinary profession as well as in the populations concerned, will be
sought and a major impact is expected by … giving a major role to women who in many cases
will be instrumental in implementing local control programmes.
Successful control of NZ depends on affected communities being aware of risk factors and
how these are intimately interwoven with their relationship with companion animals,
livestock and wildlife. Because of this, effective messaging is a control tool of overriding
importance as acknowledged by its special status within this work package. Within affected
communities, women play a key role in educating families and implementing risk avoidance
strategies and are in the front line of disease control; hence gender issues are a key
component. An important aspect will be confounding of perceptions of NZ and other diseases
(e.g. febrile conditions such as malaria, brucellosis and sleeping sickness with overlapping
symptomatologies). Health seeking behaviour is largely culturally determined and integrated
control approaches will have to analyse carefully those societal determinants to identify new
innovative avenues of individual, household and community action. The objectives for this
work package are:
1. To establish current knowledge, attitudes and practices with regards to the presence,
transmission factors, impact, and control of neglected zoonoses in the case-study area
2. To characterise and facilitate the role of women in relation to the control of neglected
diseases, not just as direct beneficiaries from improved livestock and human health, but
also in terms of their key role in the success of local control programmes
3. To review existing messaging tools in all media that are used to support disease control
activities for the neglected disease clusters addressed by ICONZ
4. To identify appropriate tools and channels to reach target communities and affect
health behaviour and environmental factors
5. To create health messaging tool kits for strategic scenario-diagnosis, planning and
targeting and monitoring of public health interventions, including a central repository
for field-tested messaging material
6. To provide overarching support to other WPs, especially WPs5–8 & WP9, on gender
issues, use of appropriate messaging and adaptation of control strategies to local
cultural contexts.
WP11
TECHNOLOGY TRANSFER AND TRAINING
The project will also provide technology transfer and training to affected countries. These
requirements can only be met through coordinated stakeholder engagement at all levels from
the inception of the project. Without effective technology transfer the project outputs will not
be sustainable. The objectives of this work package are:
1. To build diagnostic, prevention and control capacity for neglected zoonoses in targeted
African countries.
2. To train individual scientists, medics, veterinarians and other appropriate personnel
within the human health and livestock production sectors in diagnosis, epidemiology,
prevention and control of neglected zoonoses.
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3. To provide training packages on prevention and control of neglected zoonoses at
community level to medical, veterinary and agricultural personnel as well as community
leaders, livestock keepers and householders, with particular regard to the importance of
the role of women.
WP12
COMMUNICATION AND DISSEMINATION
The involvement of all the stakeholders is vital to the success of the project. Transferring the
outcomes of ICONZ to stakeholders and in particular those with responsibility for developing
and implementing control and prevention strategies in the developing countries is essential for
control of the NZ. The objectives are:
1. To secure the commitment of governments and donor bodies to control of neglected
zoonoses
2. To ensure effective communication among all stakeholders
3. To promote the activity and acceptance of an international Scientific Advisory
Committee for neglected zoonoses.
4. To disseminate and improve availability of information on all aspects of the neglected
zoonoses covered by this project
B1.2. Progress beyond the state-of-the-art
This proposal will advance the state of the art in relation to the NZ in a number of ways. The
current state of zoonoses control is characterised by major constraints, which ICONZ will
address and assist in overcoming.
B1.2(i) CONSTRAINTS TO NEGLECTED ZOONOSES CONTROL
The endemic zoonoses, although apparently not as prevalent as high profile diseases afflicting
poor countries, merit special consideration and investment for the following reasons:1. Zoonoses selectively affect poor families in poor and marginalised communities,
particularly poor pastoralists, resource poor crop-livestock farmers in remote areas and
landless livestock keepers in urban and periurban slums;
2. Their apparently low incidence is an illusion in many cases – where evidence-based
studies on under-reporting have been undertaken, the true incidence is between two and
100 times greater than that reported;
3. Zoonoses tend to be clustered in certain communities and among identifiable groups at
risk, where they impose an above average burden. This clustering offers highly costeffective control options, especially where it is possible to target more than one zoonotic
disease or to integrate the work with other human and animal health programmes;
4. In these communities, zoonoses impose a dual burden on human and animal, (mainly
livestock) health, often affecting the same household and pushing it further into poverty.
Dealing with these diseases thus reaps a double harvest, saving people’s lives and
securing their livelihoods, thus further increasing cost-effectiveness; and
5. Simple and relatively low-cost tools and strategies exist for the control of most of these
diseases, although cheap and effective bed-side and pen-side diagnostics are usually
lacking. Much can be achieved by health education and control of the animal reservoir.
B1.2(ii) MAPPING RESEARCH
The NZ pose a multifaceted problem affecting animals, humans, producers and industries in
the developing countries. No single organisation or group currently has an overview of the R
& D programmes on NZ. The project will catalogue current research into the NZ which will
identify gaps and duplications in research programmes. By pinpointing gaps in research it will
be possible to target scarce resources more effectively.
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B1.2(iii) DISEASE EPIDEMIOLOGY AND DISTRIBUTION
There is a paucity of data regarding the distribution and burden of zoonoses in developing
countries (WHO, 2006; Coleman, 2002, Knobel et al., 2003). For many diseases the
epidemiology is not properly understood making development of control strategies difficult.
A better estimate of the true prevalence of these diseases is important to assess the burdens of
disease in a given area. Disease surveillance, based on effective diagnostics underpins
successful targeting and planning of control activities. At present a combination of poor
surveillance systems, under reporting, inadequate diagnostic tools and lack of standardisation
of metrics of disease burden in man and animals leads to an inadequate knowledge base for
informing policy.
ICONZ will contribute to the systematic collection and interpretation of data on the incidence
and prevalence of these diseases in people and animals. The project will provide support and
tools for effective surveillance systems. Local level registration and reporting systems for
zoonotic diseases containing both veterinary and medical data will be developed. As a
consequence improved information on the diseases and their transmission along with the risk
factors will be made available to decision makers using GIS and expert systems.
B1.2(iv) DISEASE BURDENS
It is widely recognised that there is a lack of information on the burdens imposed by the NZ
on both animals and humans, the risk factors and the level of under reporting. ICONZ will
generate validated tools and methodologies for the assessment disease burdens. A consensus
approach to identifying the burdens of NZ in developing countries will allow a more
coordinated worldwide approach to disease control. Disease burden models will be made
widely available for sustainable use by decision makers.
ESTIMATING THE PUBLIC HEALTH BURDEN OF NEGLECTED ZOONOSES
In order to put a value on the burden of disease on human health, a number of non-monetary
measures have been developed. The most widely used currently is the Disability Adjusted
Life Year (DALY), which determines the relative burden of disease, in different settings and
at different stages of economic and public health development. As well as being used for
ranking of the overall burden of an individual disease, the DALY is also an outcome measure,
particularly useful in benefit-cost analysis in economic evaluations. There is controversy in
defining and weighting of disability and for most zoonoses, estimations of DALY do not exist
(Coleman, 2002). ICONZ will develop appropriate measures for the NZ.
ESTIMATING THE BURDEN ON COMMUNITIES OF NEGLECTED ZOONOSES IN ANIMALS
In livestock, the losses due to disease can usually be estimated in monetary terms. They
consist primarily of on-farm losses including reduced milk production, mortality (especially
in young animals), lowered meat production (due to carcass condemnations and weight loss),
reduced herd sizes due to increased mortality and lowered fertility, and increased replacement
costs associated with poor productivity and mortality. While identifying the nature of these
losses is usually relatively straightforward, given current knowledge about each disease and
its effects on animals, quantifying their extent in field situations is much more challenging.
Lastly, due to the importance of dogs and wildlife in maintaining the transmission of some of
these NZ, the ways in which these animals can be assigned a monetary value will be explored,
reflecting their importance to owners as companions, guards, herding assistants in the case of
the former and to countries as a natural resource and tourist attraction in the case of the latter.
ESTIMATING THE COST OF CURRENT CONTROL AND TREATMENT MEASURES
A significant component of the burden or cost of disease in both people and animals is the
expenditure of time and money to treat and/or control them. This too can usually be estimated
in monetary terms. In humans, these obviously include costs to the public health sector, such
as drugs, medical costs or hospital costs. There are also costs to households with patients
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suffering from a zoonosis (e.g. Odiit et al., 2004), ranging from the costs of seeking diagnosis,
to out of pocket payments for treatment and the cost of hired care or care by a family member,
usually a woman, in terms of their opportunity costs from other activities which are neglected.
For animals, nursing care, travel expenditure, vaccines, pharmaceuticals and veterinary fees
must be quantified. To these may be added the costs of zoosanitary measures such as animal
confinement, meat inspection, carcase condemnation, market closures and culling.
B1.2(v) CASE STUDIES
Implementation of case studies for defined epidemiological situations in the field will enable
information to be obtained rapidly in specific defined situations that will be of immediate use
to policy makers. Basic information will be obtained for the design of control programmes,
awareness generation and to support advocacy. Where control programmes are ongoing case
studies may take the form of operational research. These studies will provide the following:•
•
•
Assessment of the DALYs borne by individuals affected by the diseases,
Assessment of the cost of the disease to livestock production,
Identification of risk factors in both people and animals with a view to successfully
targeting at-risk groups for high priority intervention,
• Methodology for quantifying the rate of disease under-reporting in humans and animals,
• Assessment of the efficacy of disease control tools, and
• Assessment of the efficacy of control and prevention strategies, and their and
appropriateness for the communities and agencies concerned, emphasising the role of
women in both.
B1.2(vi) DISEASE CONTROL TOOLS
Tools for the control of NZ include: diagnostics, vaccines, pharmaceuticals, animal and
human health policy (e.g. movement control, confinement of animals, culling, meat
inspection, sanitation), decision support tools (e.g. epidemiological investigation and models,
databases, GIS, expert systems), messaging and publicity. However, with all diseases of poor
and neglected populations, there is little commercial motivation for funding the development
of new diagnostics, drugs or vaccines. It is not within the scope of this project to develop de
novo vaccines or pharmaceuticals for the control of NZ, since it is widely recognised that the
research and development pipeline for these tools can take up to 10 years, and that efficacy,
quality and safety testing of new products may be prohibitively expensive for pharmaceutical
companies. The WHO-DFID Sept 2005 meeting recognised that whereas many of the tools
for controlling NZ were available, there are notable gaps, particularly in diagnostics. A
system for recognizing and funding centres of excellence in zoonotic disease research, linked
to local public health systems, was recommended.
In the proposed ICONZ project, existing tools will be evaluated and where appropriate the
need for new or improved tools will be identified. Examples of appropriate disease control
tools might be a vaccine for control of rabies in dogs, or a low-cost method of applying
insecticide to cattle for control of zoonotic trypanosomiasis. The following summary of what
tools are available and what are needed was formulated by an expert working group at the
WHO/DFID 2005 meeting.
Anthrax – Control tools for anthrax must be properly delivered and applied. No cold chain is
required for the livestock vaccine, but there are quality control problems and delivery can be
problematic in pastoralist systems. In humans, cutaneous anthrax is easy to diagnose, but is
not the case for gastric anthrax. Diagnosis is constrained by poor sensitivity of existing tests,
the need for microscopic examination of samples, lack of awareness of the disease and of
trained personnel. Drugs to treat humans are available.
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Bovine tuberculosis – Better diagnostics for both people and animals are needed, in particular
to enable differentiation between human and bovine tuberculosis. Ante-mortem diagnosis is
one of the major obstacles in, especially if wildlife is involved. The STAT-PAK® system1
may represent a significant advance. In animals, excluding environmental mycobacteria is a
problem. A better BCG vaccine is also needed. Associated risk factors such as HIV need to be
recognized.
Brucellosis – Species-specific diagnosis poses difficulties and is important since human
disease severity depends on the causal agent. Medical surveillance is poor with a large
incidence of under-reporting. Vaccination should work for control in animals, but a cold chain
would be required in tropical environments therefore a recombinant vaccine would be highly
desirable.
Cysticercosis – Diagnosis in humans is problematic and field tests for taeniosis are required.
There is a strong need to measure cysticercosis in the population. Serology exists for pigs –
pen-side tests would enable epidemiological studies and control activities. A new vaccine for
pigs requires assessment (no cold chain is required). Cysticercosis is on the list of eradicable
diseases.
Echinococcosis – Better drugs for treating human cystic echinococcosis (hydatidosis) are
required. Diagnostic tools are available – ultrasound and serology. Conventional control can
work, although control structures require identifying and sustaining. Delivery systems are still
needed. The new vaccine for sheep requires assessment (no cold chain) but the new dog
vaccine is a longer-term undertaking. The dog rectal-stick test is another possibility.
Leishmaniasis 2 – The EU Parliament (2005) considers that simple, effective diagnostic tests
suited to resource-poor countries are needed, and noted that AIDS reinforces severe visceral
leishmaniasis. The traditional treatment, pentavalent antimony, has serious side effects,
requires lengthy treatment and is losing efficacy due to parasite resistance, and the EU calls
for speedy registration of promising drugs such as paromomycin and miltefosine (with the
advantage of oral administration). Practical, reliable and inexpensive diagnostic tests have
recently been developed for early detection and rapid treatment that need to be made available
in affected countries. Inter-country field research, supported by WHO, is currently comparing
diagnostics for visceral leishmaniasis. Use of insecticide-impregnated bed nets has also shown
promising results.
Rabies – Reliable, early stage, ante-mortem tests are needed in animals and humans. For
control, efficient sterilization/dog contraception must to be used in combination with rabies
vaccination. Delivery and access problems remain since the dog vaccine requires a cold chain
and achieving 70–75% immunization coverage in dog and wildlife populations is difficult.
Zoonotic trypanosomiasis – Pen-side and bed-side diagnostics are essential as are effective,
non-toxic drugs. A full range of tools for tsetse control are available, but tend not to be
sustainable outside of tsetse control programmes. Drugs to treat the animal reservoir are cheap
and readily available, but not always correctly applied. A suite of DNA technologies could be
applied; the question is whether a single test for trypanosomes or species-specific diagnosis is
more desirable. A quick technology, e.g. a simple T. brucei diagnostic or a diagnostic for all
trypanosomes based on loop-mediated isothermal amplification of DNA (LAMP), could be
produced in less than three years (Notomi et al., 2000; Kuboki et al., 2003).
Overall, the biggest gap seems to be in the field of diagnostics. Good pen-side and bed-side
diagnostics are lacking for almost all of these endemic zoonoses. This in turn is reflected in
1
http://www.chembio.com/animaltest4.html
Leishmaniasis was not specifically considered by the WHO/DFID meeting working group.
2
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the problem of under-reporting, differentiation from other more common illnesses and
difficulty in correctly diagnosing and treating patients, which have been discussed in other
sections of this report. For some diseases, simple decision support tools can be of great help in
differentiating between similar conditions affecting humans or livestock.
B1.2(vii) IMPLEMENTATION MEASURES
Control measures already exist for individual zoonoses such as rabies, anthrax,
echinococcosis, cysticercosis, and brucellosis, but a disease-based approach is often
inefficient and arguably not cost effective. Interventions are often not packaged effectively
through existing veterinary and public health structures and in some cases neither authority
accepts responsibility. Successful control programmes have shown that rational regional or
global control/elimination is possible.
ICONZ will design new intervention packages for animal diseases reflecting a change from
single disease/vertical approaches to more integrated health promotion addressing several
disease/health problems:
a) Bacterial zoonoses package. Anthrax, bovine TB and brucellosis are all bacterial diseases
for which vaccination of man and/or animals represents an important control strategy.
b) Small ruminant-dog package. This group will include echinococcosis, leishmaniasis and
rabies, which frequently occur together, particularly in pastoralist communities.
c) Pig-associated parasite package. This package comprises porcine cysticercosis, human
taeniosis and human cysticercosis and neuro-cysticercosis.
d) Vector-borne disease package. The control of African bovine trypanosomiasis, and
specifically zoonotic sleeping sickness, through insecticide application to cattle has been
shown to be effective. The synthetic pyrethroid (SP) insecticides used for this purpose
also have a marked effect on cattle ticks and tick-borne diseases. The more obvious effect
of SPs on cattle ticks may represent a strong incentive for the adoption of the this
intervention technology, with multiple benefits accruing in terms of animal and human
health.
ICONZ aims to develop control and prevention strategies for NZ in the animal reservoir
taking into account the economic, sociological and cultural aspects related to the diseases.
Once these strategies have been developed, individuals charged with responsibility for
decision making about the implementation of these strategies will wish to do so on the basis
of an understanding of their cost-effectiveness. This will apply equally to individual livestock
keepers in affected communities as it will to government decision makers in both technical
and political roles. Hence, the final objective will be to determine the comparative costeffectiveness of intervention packages developed under this project. The development of such
intervention packages will be supported by operational research to assess their impact, safety
and cost–effectiveness and by disease control and cost modelling exercises where appropriate.
POLICY MAKING
B1.2(viii)
There is a lack of prioritisation by policy makers to control NZ partly due to poor awareness
of the impact of zoonoses in animals and humans. A lack of active involvement by both the
veterinary and the human medical sectors is a contributory factor. In order to ensure that the
importance of zoonotic diseases is recognized by decision-makers and donors, effective
advocacy, firmly grounded in evidence-based assessments of the burden of these diseases on
people, animals and poor livestock-keeping communities, is needed.
There will be improved awareness through the activities of the Project Advisory Council (see
Section B2.1, below) which will be established at an early stage. ICONZ will provide
evidence for the disproportionate burden on health imposed by zoonotic diseases on the poor
and assess the dual burden which results from the effects of zoonoses on livestock with
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chronically lowered productivity, reinforcing the cycle of poverty and ill health. It will enable
donor communities and other stakeholders to be sensitised to the burden imposed by NZ.
Disease and geographical networks will be established with representatives from the
veterinary and medical sectors to ensure that policies are developed which cover both people
and animals. Existing networks will be strengthened and where appropriate new networks will
be created. This integrated approach has the potential to be extended to incorporate non-zoonotic public health and animal health problems prevalent in the same impoverished
communities.
To ensure sustainable implementation of zoonoses control strategies a range of measures have
been identified in this project. Of primary importance is the need to develop and maintain
awareness, interest and commitment at local, district, national, and international levels and
identify and publicise the most cost-effective control strategies to obtain the resources
necessary for their successful implementation. In this context, ICONZ will promote an intersectoral approach, working on the ‘one health’ principle.
B1.2(ix) ROLE OF WOMEN
The importance of women in dealing with NZ is often overlooked. There are three important
aspects of this project where women will be critical to success. The European Parliament
resolution on Major and Neglected Diseases in Developing Countries adopted in 2005
reminded the Commission of the importance of women in primary health care and that
women, children and people with disabilities need to be mainstreamed into health policies and
related statistics and research. Women have a major role to play in protecting human health.
Similarly in many cultures in the developing world women are responsible for farming
activities. If the importance of NZ and the burden they cause to animals and humans can be
demonstrated to women, they are more likely to work effectively to implement control at a
local level. This will be achieved in partnership with national or provincial/regional
governments. In reaching out to women in communities, a proportion of the policy makers
and research scientists should also be women who would be able to relate more easily to the
problems faced. Hence there will be particular attention paid to the role of women in policy
formulation. The remit of the ICONZ Advisory Council will be specifically formulated to
prioritize the role of women a) in the ICONZ Project, b) in implementation of control of NZ
and c) as beneficiaries of control activities. Further information on the role of women is given
below in Section B5.
Women are important beneficiaries of the effective control of NZ and key players in the
implementation of control strategies. This is firstly because of their role as primary carers and
those largely responsible for identifying illness in the family and seeking care for it. Secondly,
interventions to stop transmission of many of these diseases takes place at the food processing
stage (tuberculosis, brucellosis, cysticercosis) or involves the teaching of specific hygienic
practices. An integral part of developing appropriate control packages will be meeting with
women in affected communities, discussing measures most practical for them and how they
could be supported in implementing them and in extending them to their families. Women’s
involvement will then continue from planning and design through to implementation and
follow-up phases. Women’s views on how the strategies work in the field and how effective
they are will be a vital component of testing and fine-tuning the approaches developed.
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B1.3. Scientific and technological methodology and associated
work plans.
B1.3(i) OVERALL STRATEGY OF THE WORK PLAN
ICONZ will be conducted as a series of twelve work packages (WP1-WP12) the objectives of
which are described in Section B1.1. These work packages are themed on the basis of the
nature of the activities, with each cross-cutting all eight of the NZ.
THEMATIC GROUPINGS
The ICONZ work packages fall into a number of related thematic groupings. Work package
one, PROJECT MANAGEMENT & COORDINATION and WP2, MAPPING GLOBAL RESEARCH ON
NEGLECTED ZOONOSES comprise Theme A, the Virtual Institute. Theme B, Diagnosis,
burden & control tools, includes WP3, KNOWLEDGE & INFORMATION ON NEGLECTED
ZOONOSES and WP4, IMPROVE & DEVELOP DISEASE CONTROL TOOLS. Theme C, Control &
prevention strategies: integrated intervention packages comprises WP5, BACTERIAL
ZOONOSES CLUSTER; WP6, SMALL RUMINANT / DOG-ASSOCIATED ZOONOSIS CLUSTER; WP7,
PIG-ASSOCIATED PARASITE CLUSTER and WP8, VECTOR-BORNE DISEASE CLUSTER. Theme D
Overarching support measures: economic, sociological & cultural aspects includes WP9,
SOCIOECONOMIC & INSTITUTIONAL ASPECTS, and WP10, CULTURAL ASPECTS, GENDER
ISSUES, TRADITIONAL KNOWLEDGE AND MESSAGING IN THE CONTROL OF NEGLECTED
ZOONOSES. Finally, WP11, TECHNOLOGY TRANSFER & TRAINING and WP12, COMMUNICATION
& DISSEMINATION together form Theme E, Spreading excellence & capacity building. The
thematic groupings and their interrelationships are shown in Figure 2. Themes A and E may
be regarded as ‘horizontal’ integration themes, whereas themes B–D may be regarded as
‘vertical’ scientific integration themes.
Figure 2: Themes and Linkages: ICONZ Work Packages
Vertical scientific integration themes
Horizontal integration themes
B. Diagnosis, burden &
control tools
WP3 Knowledge & information
on neglected zoonoses
WP4 Improving & developing
disease control tools
A. Virtual
institute
WP1 Project
management &
coordination
WP2 Mapping global
research on
neglected
zoonoses
C. Control & prevention
strategies: integrated
intervention packages
WP5 Bacterial zoonoses cluster
WP6 Small ruminant/ dog cluster
WP7 Pig-associated parasite cluster
WP8 Vector-borne disease cluster
D. Overarching support
measures
WP9 Socioeconomic &
institutional aspects
WP10 Cultural aspects &
messaging
14
E. Spreading
excellence &
capacity building
WP11 Technology
transfer &
training
WP12 Communication &
dissemination
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WORK PACKAGE 1, aimed at implementing project management and coordination, is described
in more detail below in section B2. WP2 to WP8 are dedicated to scientific research and
technological development, and are described in more detail in this section. WORK PACKAGES
9&10 will provide overarching support particularly to WPS5–8 in two key areas of NZ control,
namely socioeconomic & institutional aspects (WP9) and cultural aspects, gender issues,
traditional knowledge and messaging (WP10). Finally, WP11 and WP12 aim at delivery and
dissemination of the project’s outputs, and are described in more detail below in section B3.
The overall work plan for the ICONZ vertical scientific integration themes will be a cyclical
process of scientific innovation and public engagement. Hence, the project will commence
with a series of international stakeholder workshops bringing together scientists, government
agencies and policy makers, international agencies, advisory groups and donors, nongovernmental organisations and representatives of communities affected by NZ. Prominence
will be given to the role of women. These workshops will be instrumental in setting the
strategic research agenda for WPS 3–10. The process will be further guided by the ICONZ
Scientific Advisory Council, whose recommendations will be implemented through the
activities of a Management Group (see B2.1.Management structure and procedures). Four
individual workshops will be held, each covering the topics of a pair of related work
packages. The groupings will be Workshop I, covering WPS3&4; Workshop II, covering
WPS5&6; Workshop III, covering WPS7&8; and Workshop IV, covering WPS9&10. Pairing
work packages will make more efficient use of ICONZ resources, since many participants
will have an interest in both topics covered. These workshops will be staggered to that
participants may attend more than one; in particular, the leaders of WPS9&10 will attend all
four in accordance with the overarching remit of their work packages. Workshops will be cochaired by the leaders of the work packages concerned, with support from the ICONZ
Secretariat (see B2.1.Management structure and procedures).
WP2: MAPPING GLOBAL RESEARCH ON NEGLECTED ZOONOSES
This workpackage lies on the cusp between research and its coordination. Working closely with
the European Technology Platform for Global Animal Health (ETPGAH), FP7 DISCONTOOLS and
the Animal Health ERA-Net to avoid duplication and generate synergies, ICONZ will synthesis the
current knowledge of the distribution and burden of NZ within this topic by gathering
information on global research activities and map any pre-existing regional/national linkages
between research programmes. An interactive database will be developed that can be populated
electronically, interrogated to identify current NZ research categories and queried to identify major
gaps in research programmes. This will include cross-cutting issues relating to human health,
sustainable agriculture and socio-economics. The information will be analysed to identify
overlaps, gaps, duplication, strengths/weaknesses, opportunities and common research
priorities. Finally, a mechanism will be developed for the ongoing updating and maintenance of the
database beyond the end of the project, in conjunction with other databases being developed by
ETPGAH, DISCONTOOLS and the ERA-Net. Activities will lead to: a)
b)
c)
d)
e)
A database of current research into diagnosis, burdens and control of each of the NZ;
A list of experts and institutes working on these topics;
A report on the significant research gaps in the above areas;
Improved networking among key researchers on the target zoonoses; and
A final report on the research requirements.
ICPC CASE STUDIES
The work packages (WPS3-10) comprising vertical scientific integration themes B–D (see
figure 2) will be in undertaken in the context of a number of case studies to be conducted in
seven of the ICPCs participating in ICONZ, namely Mali, Morocco, Mozambique, Nigeria,
Tanzania, Uganda and Zambia. (South Africa, another participating ICPC, will provide
15
FP7-KBBE-2007-1-3-09
Part B
ICONZ
support though epidemiological modelling at SACEMA, Stellenbosch University, but will not
host a case study.) These case studies will span a representative range of situations where one
or more of the neglected zoonotic disease clusters identified above (see WPS5–8) are known to
occur with measurable impact.
The case studies envisaged will fall broadly into two phases. The first phase will consist of
inventorying existing knowledge on the NZ in the case study areas; in particular their impact
and burden (WP3), and the efficacy (WPS5–8), cost (WP9) and cultural aptness (WP10) of
current control and prevention strategies. This will involve compiling information and data
from existing sources (e.g. existing scientific literature, hospital and other medical records,
animal production and health reports, and any available unpublished data) in order to
complete the information needed, as far possible. At the end of this phase a gap analysis will
be performed and the need for collection of missing information will be assessed.
Following this assessment, where new information is required, the second phase will consist
of collecting data by undertaking field work. Here the emphasis of ICONZ will be on
obtaining data that evaluates and validates control and prevention strategies. The approach
will be to address clusters of NZ, with strategies grouped into integrated intervention
packages. Where possible, these activities will be undertaken as operational research linking
into ongoing projects having their own complementary funding, thereby maximising the value
of the ICONZ project budget and indeed those of the ongoing projects.
The precise location of ICPC case studies will be determined during a number of initial
stakeholder workshops to be held in association with groupings of work packages within
each of the three vertical scientific integration themes. Preliminary stakeholder discussions
have already been conducted and strongly suggested a number of potential case study areas.
Examples of these would be the Timbuktu area of Mali, with emphasis on the neglected
bacterial zoonosis cluster; selected areas in Morocco for the dog / small ruminant-associated
zoonosis cluster; the Lakes Kyoga and Victoria Basin area of Uganda, with emphasis on the
vector-borne zoonosis, pig-associated parasitic zoonosis and bacterial zoonosis clusters; and
Northern Tanzania, where for all four neglected zoonosis clusters are probably important.
WP3: KNOWLEDGE AND INFORMATION ON NEGLECTED ZOONOSES
Better data on distribution and burden of targeted NZ are required for the improvement of
tools and control strategies to be developed in WP4 and WPS5–8. Existing databases will be
used (e.g. ARIS developed by PACE) and where necessary new databases will be developed.
Geographic information systems (GIS) will be used to collate, analyse and display the
information, using modelling techniques such as logistic regression, discriminant analysis,
artificial neural networks, random regression forests and ecological niche factor analysis. An
important component of this work package will be risk mapping.
Work package 3 builds on a “one health” approach combining human and animal health
within societies and ecosystems. No human clinical and serological studies will be conducted
under ICONZ; all human data will be collected with independent funding.
While many zoonoses have been well controlled or even been eliminated in industrialised
countries, most developing countries do not have the capacity and the means to control them
(Zinsstag et al. 2007); accordingly the first step in addressing the NZ is to assess their burden
to animals and humans in terms of disease occurrence (Kayali et al. 2006), livestock
productivity losses (Roth et al. 2003) and public health impact (Coleman et al. 2004). WP3
aims to develop and test sustainable data collection and reporting systems for zoonoses in
Africa.
The four objectives of WP3 build on each others outcomes and relate to objectives of other
WPs including WP2; providing baseline data to map NZ - WP4; using locally adapted
16
FP7-KBBE-2007-1-3-09
Part B
ICONZ
diagnostic tools - WP5; addressing bacterial and parasitic zoonoses - WP6. WP3 will assist in
monitoring all WPs dealing with control efforts: WP10 - considering actor perception and
cultural practices and WP9 - assessing the economic impact of disease and cost-effective
interventions. WP3 will integrate with the network on bovine tuberculosis in 8 ICPC countries
(funded by the Wellcome Trust) that provides training on diagnosis of NZ and a platform for
ICPC country workshops. Local priorities for case studies and study areas will be identified
by participatory methods with local communities (Zinsstag 2007, Schelling et al. 2008).
A standardised method for quantifying the burden of NZ in humans will be used to develop
evidence based disability weighting factors for zoonoses (as has been done e.g. for brucellosis
(Roth et al. 2003)). A comprehensive literature review will assess the relationship of testing
results and clinical outcome in humans and animals e.g.: the relationship of tuberculin
positive animals to productivity losses (Zinsstag et al. 2006); the proportion of brucellosis
sero-positive ruminants that have aborted (Zinsstag, Roth et al. 2005); the proportion of
epileptic patients with neurocysticercosis (Carabin et al. 2005). Diagnostic test results will be
related to productivity and clinical outcomes by whole herd investigations in endemic
populations.
WP3 will build on methods of Schelling et al. (2003) for integrated human-animal risk-based
surveillance system for combined zoonoses; role of sentinels; syndromic and communitybased surveillance (e.g. fever complex and abortion complex) and will aim at optimising
resources for disease surveillance while maintaining sensitivity and specificity. Official
record data and new geo-referenced sampling will allow national mapping of NZs. Such
spatial representations are important to relate temporal and spatial dimensions of transmission
to control efforts.
For priority NZ, locally important risk factors will be assessed for transmission among
livestock and to humans: behavioural and biological determinants as well as cultural and
social risk factors will be assessed. Underreporting, a central feature of NZ, will be addressed
by comparing ongoing reporting systems, optimized surveillance systems and representative
cross-sectional cluster surveys as case studies.
With WP4, standard diagnostic tests will be compared to new serological tests (e.g.
fluorescence polarisation, lateral flow), molecular tools and chip technology for their use as
screening and routine tools either laboratory-based and/or as pen-side/point of care test.
With WP9, WP3 will assess societal costs of NZ to inform policy, involving traditional and
intensive production systems both private and governmental, to link the impact of zoonoses
with market value chains (e.g. milk production systems) and human health costs. These
disease-cost assessments (see Zinsstag, Roth et al. 2005) will involve WP5 (brucellosis,
bovine tuberculosis, anthrax) and WP6 (echinococcosis, rabies). Total societal costings for
pig-associated (WP7) and vector-borne diseases (WP8) will be developed.
Activities will lead to: a) Standardised and accepted methods for quantifying the burden of neglected zoonoses in humans
based on medical data;
b) Improved information on the incidence & prevalence of these diseases in animals and humans;
c) An assessment of the burden of neglected zoonoses in humans in affected communities and their
cost to livestock production in terms of DALYs and other economic indicators and total societal
burden;
d) A validated methodology for quantifying the rate of underreporting;
e) A risk-based surveillance framework integrated in existing livestock and health services works at
low cost with high sensitivity/specificity;
f) Identification of the main determinants of transmission between animals in ICPC case studies;
g) Assessment of societal geo-referenced burden and cost of zoonoses in ICPC case studies.
17
FP7-KBBE-2007-1-3-09
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ICONZ
WP4: IMPROVE AND DEVELOP DISEASE CONTROL TOOLS
We will improve or develop disease control tools where needed and appropriate for the
conditions prevailing in affected countries and communities. Disease control tools in the
broadest sense include the following categories each of which will be considered in this work
package: diagnostics, vaccines, pharmaceuticals, animal and human health policy (e.g.
movement control, confinement of animals, culling, meat inspection, sanitation), decision
support tools (e.g. epidemiological investigation and models, databases, GIS, expert systems)
and messaging and publicity. This work package will lend support to the creation of regional
centres of excellence in diagnosis of NZ in ICPC countries in affected regions, which will
serve the function of diagnostic reference laboratories. Emphasis will be given to the
validation, improvement and distribution of existing candidate diagnostics, with SME
involvement as appropriate. Activities will lead to: a) A catalogue of currently available tools for each of the listed neglected zoonoses, including gaps
in availability;
b) Detailed information on the suitability of individual disease control tools for the different conditions
prevailing in endemic developing countries;
c) A list of specific research requirements to prioritise development of new and improved control
tools;
d) Validated tools for control of neglected zoonoses, for use in both humans and animals in
developing countries, under both field conditions and in reference laboratories.
WPS5–8: IMPROVE AND DEVELOP CONTROL AND PREVENTION STRATEGIES: INTEGRATED
INTERVENTION PACKAGES
Integrated intervention packages will be developed for integrated control of clusters of NZ
and other diseases within a particular livestock species, and across livestock species within a
particular community. Examples would be:(i) intersectoral approaches for joint animal and public health interventions, for example interministerial cooperation for societal benefit of brucellosis control, combining anthrax and
childhood vaccination, and coordinated cysticercosis control in man and animals;
(ii) interspecies approaches covering multiple zoonotic diseases as in the case of intervention
packages for integrated control of echinococcosis, leishmaniasis and rabies in dogs and small
ruminants; and
(ii) species-specific intervention packages for multiple zoonotic and non-zoonotic diseases as
in the control of trypanosomiasis, tick-borne diseases and in some areas malaria using
application of insecticides/acaricides to cattle.
Hence four work packages will address control and prevention of clusters of NZ, with an
emphasis on the development and validation of integrated intervention packages aimed at
simultaneously addressing the various diseases comprising the cluster:

WP5 NEGLECTED BACTERIAL ZOONOSES CLUSTER (anthrax,
bovine tuberculosis & brucellosis),
WP6 NEGLECTED SMALL RUMINANT / DOG-ASSOCIATED ZOONOSIS CLUSTER (cystic
echinococcosis,
leishmaniasis & rabies),

WP7 NEGLECTED PIG-ASSOCIATED PARASITIC ZOONOSIS CLUSTER
(porcine cysticercosis,
neurocysticercosis & taeniosis) and

WP8 NEGLECTED VECTOR-BORNE ZOONOSIS CLUSTER (zoonotic trypanosomiasis, tick-borne animal
diseases & malaria [in some areas]).
Determining comparative cost-effectiveness of intervention packages will empower
communities and policy makers to utilise them effectively. Activities will lead to: a) Improved control and prevention strategies for neglected zoonoses based on combinations of
individual disease control tools optimised for use in particular situations;
18
FP7-KBBE-2007-1-3-09
Part B
ICONZ
b) Integrated intervention packages addressing groups of related neglected zoonoses targeting
specific human populations and their livestock;
a) Operational research results indicating the effectiveness, safety and impact of integrated
intervention packages;
b) Information and options for control suitable for use by governments and donor bodies
WP9
SOCIOECONOMIC & INSTITUTIONAL ASPECTS OF THE CONTROL OF NEGLECTED
ZOONOSES
This work package will provide guidelines and protocols for socio-economic data collection
and institutional analysis within the case studies, and be highly complementary to WP3.
Together these two work packages aim to address the issues arising out of the dual nature of
zoonoses. Control or even elimination of many zoonoses is only possible if the disease is
effectively controlled in the animal reservoir. The veterinary sector usually needs to
implement these measures, but is reluctant to bear the cost as the main benefit is seen as
accruing to human health. However, from the public health sector perspective, the high costeffectiveness of control interventions must be clearly demonstrated. A recent economic
analysis of a livestock brucellosis mass vaccination campaign to reduce human brucellosis has
shown that for the public health sector this intervention is not profitable. But if the benefits
for the livestock sector are added and the costs of the intervention are shared between the
public health and the agricultural sector in proportion to their benefits, the control of
brucellosis is profitable for both sectors (Roth et al., 2003). The method used is known as
‘separable costs’. Similar results have emerged from unpublished preliminary work on rabies
and zoonotic trypanosomiasis (Shaw and Sibanda, 2000). It is important to be aware of the
costs incurred by patients and their families and how they influence health-seeking behaviour
and the success of control strategies (Odiit et al., 2004). Careful calculation and analysis of
costs of different strategies (e.g. Kayali et al., 2006, Lutumba et al., 2005 and Shaw and
Cattand, 2001) can provide unexpected insights and thus greatly inform the choice of control
strategy. Building on such cost analyses, in the field of zoonoses control, novel forms of
delivery can then be explored (Bechir et al., 2004, Zinsstag, 2007). Activities will lead to: a) A detailed understanding of the cost effectiveness of different options for control and prevention of
neglected zoonoses; and
b) Effective medical-veterinary intersectoral collaborations for the control of neglected zoonoses in
humans and animals.
WP10 CULTURAL ASPECTS, GENDER ISSUES, TRADITIONAL KNOWLEDGE AND MESSAGING IN
THE CONTROL OF NEGLECTED ZOONOSES
This work package will ensure that economic, sociological and cultural aspects related to the
diseases as well as traditional knowledge, attitudes and practices are integrated into control
and prevention strategies for NZ. The role of women both in the veterinary profession as well
as in the populations concerned will be instrumental in implementing local control
programmes. Successful control of NZ depends on affected communities being aware of risk
factors and how these are intimately interwoven with their relationship with companion
animals, livestock and wildlife. Because of this, effective targeted messaging is a control tool
of overriding importance as acknowledged by its special status within this work package.
Within affected communities, women play a key role in educating families and implementing
risk avoidance strategies; hence gender issues are a key component. An important aspect will
be confounding of perceptions of NZ and other diseases (e.g. febrile conditions such as
malaria, brucellosis and sleeping sickness with overlapping symptomatology). Health seeking
behaviour is largely culturally determined and integrated control approaches will have to
analyse carefully those societal determinants to identify new innovative avenues of individual,
household and community action. Successful interventions rely on effective buy-in from
local communities, implementers and policy makers. It is important to determine local
19
FP7-KBBE-2007-1-3-09
Part B
ICONZ
perceptions of disease in domestic animals (Machila et al., 2007). In Southern Uganda the
radio messaging has been found to be a useful and appropriate tool for delivering health
messages for both human sleeping sickness and animal health. The PRECEDE-PROCEED
planning model (Green and Kreuter, 1999) has been successfully used in Tanzania, to plan a
health promotion strategy for control of Taenia solium infections in northern Tanzania Ngowi
et al., 2007 to develop and refine appropriate public health intervention(s) identifying
environmental and behavioural risk factors of high importance and changeability. By
harnessing the power of these types of planning tool to identify risk and linking to a strong
culturally appropriate and behaviourally targeted health messaging campaign, sustainability of
control can be achieved for the NZ. By integrating health messages through addressing
diseases clusters added value and sustainability can be assured through ICONZ.
INTERDEPENDENCIES
The interdependencies among the work packages are shown in Figure 1 on page 4 and Figure
2 on page 14.
SIGNIFICANT RISKS AND CONTINGENCY PLANS
The ICONZ scientific and technological methodology and associated work plan is dependant
upon continued political stability in the participating ICPCs. The participating ICPCs in
ICONZ are all countries with a history of recent political stability. However, recent history
shows that no country is completely immune from the possibility of unexpected turn of events
and this has been factored into the ICONZ international partnership strategy. All of the NZ to
be studied occur in more than one ICPC partner country. Should political stability become a
serious constraint to progress in any individual ICPC, the case study in that country will be
suspended and work on the NZ in question will be refocused on case studies in other
unaffected participating ICPCs.
20
FP7-KBBE-2007-1-3-09
B1.3(ii)
Part B
ICONZ
TIMING OF THE DIFFERENT WPS AND COMPONENTS
Project Year:
Month:
1
2
3
4
5
I
VII
I
VII
I
VII
I
VII
I
VII
M1.1
M1.2
M1.3
M1.4
Ö
M1.4
Ö
M1.4
Ö
M1.4
Ö*
Ö
Ö
Ö
Ö
M2.1
M2.2
Ö
Ö
M3.1
Ö
Ö
Ö
Ö
Ö
M3.2
M3.4
M3.3
Ö
M4.1
Ö
Ö
Ö
M4.2
Ö
Ö
Ö
M4.3
WP
1
2
3
4
5-8
5
6
7
8
9
10
11
12
Project Management
& Coordination
Mapping global
research on neglected
zoonoses
Knowledge &
information on
neglected zoonoses
Improvement &
development of
disease control tools
Improve & develop control & prevention strategies through integrated intervention packages for:
Neglected bacterial
zoonoses
Dog / small
ruminant-associated
neglected zoonoses
Neglected pigassociated parasitic
zoonoses
Neglected vectorborne zoonoses
Socio-economic &
institutional aspects
Cultural aspects,
gender issues,
traditional knowledge
& messaging in the
control of neglected
zoonoses
Capacity building
through technology
transfer & training
Ö
M5.1
Ö
M5.2
Ö
Ö
Ö
Ö
M5.3
Ö
M6.1
Ö
M6.2
Ö
Ö
Ö
Ö
M6.3
Ö
M7.1
Ö
M7.2
Ö
Ö
Ö
Ö
M7.1
Ö
M8.1
Ö
M8.2
Ö
Ö
Ö
Ö
M8.3
Ö
Ö
M9.1
Ö
Ö
Ö
Ö
Ö
Ö
M9.2
Ö
Ö
M10.1
Ö
M10.2
Ö
Ö
Ö
Ö
M10.3
Ö
M11.1
Ö
Ö
Ö
Ö
M11.2
Ö
M11.3
Communication &
dissemination
Ö
M12.2
M12.1
M12.4
Ö
M12.1
M12.4
M12.3
Ö
M12.1
M12.4
Ö
M12.1
M12.4
Ö
M = milestone. Milestones shown in Table 1.3e.
* M1.5, Final scientific report at end of project
A more detailed Gantt chart showing timing of individual tasks within work packages is
included in Appendix III
21
M12.1
M12.4
FP7-KBBE-2007-1-3-09
B1.3(iii)
Work
package
No 3
Part B
ICONZ
WORK PACKAGE LIST / OVERVIEW
Work package title
Type of
activity 4
Lead
participant
No 5
Lead beneficiary
short name
Personmonths 6
Start
month 7
End
month7
1
Project management and coordination
MGT
1
UEDIN
127
1
60
2
Mapping global research on neglected
zoonoses
RTD
11
ULIV
100
1
60
3
Knowledge and information on neglected
zoonoses
RTD
10
STI
486
1
60
4
Improvement and development of disease
control tools
RTD
2
ITM
405
1
60
5
Improve and develop control and
prevention strategies through integrated
intervention packages for neglected
bacterial zoonoses
RTD
8
UNAV
405
1
60
6
intervention packages for dog/ small
ruminant-associated neglected zoonoses
RTD
4
AFSSA
222
1
60
7
intervention packages for neglected pigassociated parasitic zoonoses
RTD
14
UEM
246
1
60
8
intervention packages for neglected vectorborne zoonoses
RTD
16
MAK
232
1
60
9
Socio-economic and institutional aspects
RTD
20
Avia-GIS
289
1
60
10
Cultural aspects, gender issues, traditional
knowledge and messaging in the control of
neglected zoonoses
RTD
18
SUA
313
1
60
11
Capacity building through technology
transfer and training
OTHER
3
UCPH
379
1
60
12
Communication and dissemination
OTHER
1
UEDIN
418
1
60
TOTAL
3
4
3622
Workpackage number: WP 1 – WP n.
Please indicate one activity per work package:
RTD = Research and technological development (including any activities to prepare for the
dissemination and/or exploitation of project results, and coordination activities); DEM =
Demonstration; MGT = Management of the consortium; OTHER = Other specific activities, if
applicable in this call.
5
6
7
Number of the participant leading the work in this work package.
The total number of person-months allocated to each work package.
Measured in months from the project start date (month 1).
22
FP7-KBBE-2007-1-3-09
B1.3(iv)
Part B
DELIVERABLES LIST
Del.
no. 8
Deliverable name
1.1
1.2
An appropriate governance structure in place
Management Board comprising Coordinator & WP Leaders
established and effective
Advisory Council (Steering Group) comprising stakeholder
group representatives, & observers from relevant services of
the EC, established and effective
Stakeholder workshops organised and conducted
Interim Scientific and Financial Reports submitted
Final Scientific Report submitted
Database established for detailing research into each
neglected zoonoses with web access for data entry and
analysis.
Comprehensive standardised analysis for each of the
neglected zoonoses identifying current research into
diagnosis, burdens and controls
Report on research requirements to fill the gaps and
encourage the development of diagnostics, controls
strategies and information on burdens of disease
Published information on research programmes and
requirements for each neglected zoonoses
Develop methods to update the database and secure future
of the database for use after cessation of the project.
Standardised methodology for quantifying the burden of NZ,
including disease based disability weighting factors for DALY
developed from workshop outputs
Impact of NZ on livestock productivity losses
Gauged levels of underreporting of different surveillances
systems and recommendations for risk-based surveillance
frame integrated in existing livestock and health services
works at low cost and high sensitivity/specificity
Main determinants of transmission between animals
identified in case countries
Spatial dataset required for ICONZ objectives for all ICPCs
Livestock mapping tool available for use in case study area
Spatial analysis reports of disease distribution (as part of
annual reports) and contribution to papers
Societal geo-referenced burden and cost of zoonoses
assessed in case countries
Contribute to test new diagnostic tools and to assess costeffectiveness of interventions in cooperation with other WPs
A catalogue of currently available tools for each of the listed
NZ as outputs from workshop, including gaps in availability.
1.3
1.4
1.5
1.6
2.1
2.2
2.3
2.4
2.5
3.1
3.2
3.3
3.4
3.5
3.6
3.7
3.8
3.9
4.1
9
10
11
ICONZ
WP
no.
Lead
beneficiary
Nature 9
Dissemination
level 10
Delivery
date 11
O
PP
M1
1
1
Estimated
indicative
personmonths
3
1
1
6
O
PP
M3
1
1
6
O
PP
M6
1
1
1
1
1
1
20
32
60
O
R
R
PU
PP
PP
M6-M54
M12,30,48
M60
2
11
4
O
PU
M15
2
11
72
R
PU
M27
2
11
4
R
PU
M36
2
11
14
R
PU
M42
2
11
6
O
PU
M60
3
10
55
R
PU
M18
3
10
22
R
PU
M54
3
10
55
R
PU
M60
3
10
59
R
PU
M54
3
3
10
10
59
59
O
O
PP
PP
M24
M12
3
10
59
O
PU
M36-60
3
10
59
O
PU
M60
3
10
59
O
PU
M48
4
2
85
R
PU
M12
R = Report, P = Prototype, D = Demonstrator, O = Other
PU = Public
PP = Restricted to other programme participants (including the Commission Services).
RE = Restricted to a group specified by the consortium (including the Commission Services).
CO = Confidential, only for members of the consortium (including the Commission Services).
Measured in months from the project start date (month 1).
23
FP7-KBBE-2007-1-3-09
Part B
Del.
no.
Deliverable name
WP
no.
Lead
beneficiary
4.2
New and/or improved control tools (validated under
laboratory conditions) will be available
Field validated control tools for neglected zoonoses
available
Report of inaugural workshop and resulting gap
analysis
Improved control and prevention strategies for bacterial
zoonoses based on combinations of individual disease
control tools optimised for use in particular situations
Operational research results supporting effectiveness,
safety & impact of integrated control packages
Integrated cost-effective disease control packages
addressing groups of related bacterial zoonoses
targeting specific human populations and their livestock
Materials for training and capacity building activities
Interim progress reports, advocacy material and
strategic options for control and prevention of NZ
analysis
Improved control and prevention strategies for small
ruminant & dog associated zoonoses based on
combinations of individual disease control tools
optimised for use in particular situations
addressing groups of small ruminant and dog
associated zoonoses targeting specific human
populations and their livestock
Materials for training & capacity building activities
Annual progress reports, advocacy material and
analysis
Improved control and prevention strategies for pigassociated parasitic zoonoses based on combinations
of individual disease control tools optimised for use in
particular situations
addressing groups of pig-associated parasitic zoonoses
targeting specific human populations and their livestock
Report of inaugural workshop and gap analysis
Improved control and prevention strategies for vectorborne diseases based on combinations of individual
disease control tools optimised for use in particular
situations
safety & impact of integrated control packages (M48).
addressing groups of vector-borne diseases targeting
specific human populations and their livestock
4
2
4
4.3
5.1
5.2
5.3
5.4
5.5
5.6
6.1
6.2
6.3
6.4
6.5
6.6
7.1
7.2
7.3
7.4
7.5
7.6
8.1
8.2
8.3
8.4
ICONZ
Estimated
indicative
personmonths
Nature
Dissemination
level
100
O
PU
M24-36
2
220
O
PU
M60
5
8
20
R
PU
M12
5
8
50
R
PU
M24
5
8
195
R
PU
M48
5
8
60
R
PU
M54
5
8
25
O
PU
5
8
55
R
PU
M24-48
M12, 30,
48, 60
6
4
20
R
PU
M12
6
4
20
R
PU
M24
6
4
98
R
PU
M48
6
4
30
R
PU
M54
6
4
24
O
PU
6
4
30
R
PU
M24-48
M12, 30,
48, 60
7
14
12
R
PU
M12
7
14
76
R
PU
M24
7
14
74
R
PU
M48
7
14
30
R
PU
M54
7
14
24
O
PU
7
14
30
R
PU
8
16
21
R
PU
M24-48
M12, 30,
48, 60
M12
8
16
22
R
PU
M24
8
16
95
R
PU
M48
8
16
40
R
PU
M54
24
Delivery
date
FP7-KBBE-2007-1-3-09
Part B
Del.
no.
Deliverable name
WP
no.
Lead
beneficiary
8.5
8.6
Expert advise on socio-economic and institutional
aspects at inaugural workshops
Data collection checklists & protocols for analysing the
costs of the different control strategies for the NZs in
the study from workshop output
Comparative analysis of costs of different control
methods for each of the NZ clusters in the study
With WP3, calculation of cost-effectiveness of different
strategies for controlling NZs
Guidelines and recommendations for cost-sharing
arrangements between medical and veterinary sectors
Guidelines and recommendations for liaison and
structuring organisational and institutional links between
the various groups responsible for controlling
Together with other WP3, provision of background
information on which to base advocacy and
dissemination activities under WP12
Expert advise on cultural aspects, gender issues,
traditional knowledge, messaging at WP-workshops
Defined current knowledge attitudes and practices for
the presence, transmission factors, impact, and control
of neglected zoonoses in the ICPC case-study areas
from workshop outputs
Role of women in the control of zoonoses defined at all
levels of engagement
All available messaging tools identified
Channels for communication of zoonoses messages
identified
Health message tool kits developed and trialed for
disease clusters WP5 to 8
Repository for messaging materials established and
shared with policy makers & field practitioners
Inventory of currently available relevant training courses
at local, regional and international levels (M12) and
needs and opportunities assessment on
national/institutional capacity building from African
partner institutes
At least 4 research training programmes on diagnosis,
epidemiology, prevention and control of NZ conducted
Electronic-learning module on prevention and control of
zoonoses clusters for different target groups produced
Tailored distance learning exercises using relevant
ICONZ data for GIS-Epidemiology module
Community level training programme “toolkits” for each
of the 4 disease control and prevention strategies
packages produced
Policy-makers appraised of importance of NZ including
burdens and cost in humans & animals
Active website, including online stakeholder forum
Operational ICONZ data archive
Bi-annual ICONZ newsletter
8
16
8
16
9
9.1
9.2
9.3
9.4
9.5
9.6
9.7
10.1
10.2
10.3
10.4
10.5
10.6
10.7
11.1
11.2
11.3
11.4
11.5
12.1
12.2
12.3
12.4
ICONZ
Estimated
indicative
personmonths
24
Nature
Dissemination
level
O
PU
30
R
PU
20
20
O
PP
M12
9
20
60
R
PP
M18
9
20
60
R
PU
M54
9
20
33
R
PU
M60
9
20
28
R
PU
M60
9
20
28
R
PU
M60
9
20
60
R
PU
M60
10
18
12
O
PP
M12
10
18
30
R
PU
M12
10
18
24
R
PU
M12
10
18
24
R
PU
M24
10
18
82
R
PU
M24
10
18
120
O
PU
M36-48
10
18
21
O
PU
M60
11
3
47
R
PU
M12
11
3
100
O
RE
M12
11
3
60
O
RE
M36-60
11
3
60
O
RE
M36-60
11
3
112
O
PU
M42
12
1
100
O
PU
continuous
12
12
1
1
50
20
O
O
PU
PP
12
1
36
O
PU
M6
M24
M6 & every
6-months
25
Delivery
date
M24-48
M12, 30,
48, 60
FP7-KBBE-2007-1-3-09
Part B
Del.
no.
Deliverable name
WP
no.
Lead
beneficiary
12.5
Reports of inaugural and annual ICONZ project coordination meetings
Report series of guidelines for control and prevention of
individual NZ and NZ clusters
National reports for all ICPC, appraising control options
and policy implications
Media engagement
Scientific publication in form of individual research
papers and dedicated journal issues
12
1
12
12.6
12.7
12.8
12.9
ICONZ
Estimated
indicative
personmonths
Nature
Dissemination
level
36
R
PP
1
30
R
PU
12
1
22
R
PU
M48
12
1
24
O
PU
continuous
12
1
100
O
PU
continuous
26
Delivery
date
M3 & every
12 months
Completed
by M60
FP7-KBBE-2007-1-3-09
B1.3(v)
Part B
ICONZ
WORK PACKAGE DESCRIPTIONS
Workpackage number
WP1
Start date or starting event: Month 1
Workpackage title:
Project Management and Coordination
Activity Type:
MGT
1
2
3
4
8
Participant number
ITM
UCPH
AFSSA
UNAV
Participant short name
UEDIN
50
2
2
2
2
Person-months per participant:
10
11
14
16
18
20
Participant number
AVIAParticipant short name
STI
ULIV
UEM
MAK
SUA
GIS
2
2
21
21
21
2
Objectives
1. To ensure the effective management of the project so that it meets its objectives
2. Networking and liaison within the consortium
3. Promotion of international partnerships
Description of work (possibly broken down by tasks (T) and role of participants Neglected zoonoses (NZ)
T1.1 An appropriate governance structure for ICONZ will be established and maintained.
T1.2 A Management Board comprising the ICONZ coordinator and work package leaders will be convened,
with annual physical meetings and quarterly interim meetings by teleconferencing.
T1.3 An Advisory Council (Steering Group) will be established comprising all ICONZ consortium partners,
stakeholder group representatives, & observers: Representatives of EU DG-Research & DG-Development, DGSANCO, EFSA, etc.
T1.4 A stakeholder forum will be established in conjunction with WP12 Communication & Dissemination and
implemented through appropriate sessions at ICONZ workshops and a dedicated area of the ICONZ website.
T1.5 Interim scientific and financial reports will be submitted to the European Commission.
T1.6 A final scientific report will be compiled at the end of the ICONZ project cycle.
Deliverables (brief description and month of delivery)
1.1
An appropriate governance structure in place (M1)
1.2
Management Board comprising Coordinator & WP Leaders established and effective (M3)
1.3
Advisory Council (Steering Group) comprising all ICONZ consortium partners, stakeholder group
representatives, & observers: Representatives of EU DG-Research & DG-Development, DG-SANCO,
EFSA, etc. established and effective (M6)
1.4
Stakeholder workshops organised and conducted (M6-54)
1.5
Interim Scientific and Financial Reports submitted (M12, 30, 48)
1.6
Final Scientific Report submitted (M60)
27
FP7-KBBE-2007-1-3-09
Part B
ICONZ
WP2 MAPPING GLOBAL RESEARCH ON NEGLECTED ZOONOSES
Workpackage number
Workpackage title:
Activity Type:
Participant number
Person-months per participant
Month 1
Start date or starting
event:
Mapping global research on neglected zoonoses
RTD
WP2
1
11
12
13
14
UEDIN
ULIV
LCV
IAHV2
UEM
1
29
10
8
10
15
NVRIVOM
10
16
17
18
19
MAK
SU
SUA
UNZA
10
2
10
10
Objectives
1. To provide a clear picture of current worldwide research into diagnosis, burdens and control of neglected
zoonoses.
2. To evaluate and analyse the information gathered to identify significant gaps in the research into NZ.
3. To encourage networking among the key workers on neglected zoonoses targeted in this call.
T2.1 Identify and agree the relevant criteria and information necessary to catalogue and analyse worldwide NZ
research working closely with the European Technology Platform for Global Animal Health , FP7
DISCONTOOLS and the Animal Health ERA-Net to avoid duplication and generate synergies (P1,11).
T2.2 Develop an interactive database which can be populated electronically, interrogated to identify current NZ
research categories and queried to identify major gaps in research programmes (P11).
T2.3 Collect information on research for each of NZ in this proposal in a standard format with the development of
a web based on-line system for collection of information. Establish a panel/working group of stakeholders to
validate and agree the information provided on line using electronic methods. Develop an updating system (P1119).
T2.4 Identify the queries necessary to highlight the gaps in the NZ research programmes using experts for each
specific disease (P11).
T2.5 Develop a programme to interrogate the database to obtain the answers to the queries and identify the gaps
in the research programme for each NZ. Peer review the results of the database queries and obtain agreement on
the priorities for targeting research in future, finalise and publish the output (P11).
T2.6 Produce a report for each NZ listing the gaps and identifying the research required to develop improved
diagnostics, more effective strategies for the holistic control of the NZs and the provision of detailed evidence on
the burdens imposed by the NZ in order to justify control measures (P11).
T2.7 Develop a mechanism for the ongoing updating and maintenance of the database beyond the end of the
project in conjunction with other databases being developed by ETPGAH, DISCONTOOLS and the ERA-Net
(P11).
Most of the work in this WP2 cannot be divorced from that in the other WPs of this proposal. Some of this work
will be developed through expert/working groups, stakeholders, seminars and workshops as appropriate.
Networking will be encouraged through this work programme (P1, P11-19).
2.1 Database established for detailing research into each neglected zoonoses with web access for data entry and
analysis. Closely linked to other similar databases currently being developed as part of FP7 funding (M15).
2.2 Comprehensive standardised analysis for each of the neglected zoonoses identifying current research into
diagnosis, burdens and controls (M27).
2.3 Report on research requirements to fill the gaps and encourage the development of diagnostics, controls
strategies and information on burdens of disease (M36).
2.4 Published information on research programmes and requirements for each neglected zoonoses (M42).
2.5 Develop methods to update the database and secure future of the database for use after cessation of the
project. (M60).
28
FP7-KBBE-2007-1-3-09
Part B
ICONZ
WP3 KNOWLEDGE AND INFORMATION ON NEGLECTED ZOONOSES
Workpackage number
Workpackage title:
Activity Type:
Participant number
Participant number
WP3
Start date or starting event:
Knowledge and information on neglected zoonoses
RTD
2
ITM
2
13
IAVH2
41
3
UCPH
1
14
UEM
50
4
AFSSA
5
15
NVRI
50
5
UCBL
11
16
MAK
50
7
UMINHO
15
17
SU
20
8
UNAV
6
18
SUA
40
9
KI
15
19
UNZA
50
Month 1
10
STI
50
20
AVIA-GIS
24
12
LCV
50
22
ILRI
6
Objectives
1. To provide essential epidemiological and sociological information on each of the neglected zoonoses.
2. To develop a standardised methodology for quantifying the burden and cost of neglected zoonoses.
4. To utilise these methodologies to quantify the overall burden of neglected zoonoses targeted in the call in
humans and animals.
T3.1 Workshop held in collaboration with WP4 to develop a standardised methodology for quantifying the
human disease burden using evidence based disability weightings of neglected zoonoses (P2,3,10,17,20).
T3.2 Review of the methods available and recommendations on the best practice for quantifying productivity
losses due to NZ in livestock and dogs (P2,3,10,20).
T3.3 Improve national and international information on the incidence & prevalence of NZ by assessing the level
of under-reporting of NZ by investigating integrated human-animal risk-based surveillance systems, role of
sentinels, syndromic and community based surveillance in animals and comparison to results from cross-sectional
cluster surveys of case studies (P2,3,4,5,7,8,9,10,12,13,14,15,16,17,18,19,20,22)
T3.4 Assess local risk factors (behavioural & biological) for the transmission of zoonoses in case study areas
(P10,12,13,14,15,16,18,19,20).
T3.5 Collection of spatial data topics relevant to ICONZ for all ICPC countries within ICONZ
(P12,13,14,15,16,17,18,19,20)
T3.6 Develop a livestock census tool enabling the automated generation of livestock distribution maps (P20)
T3.7 Spatial analysis inputs as required for case studies, to analyse the spatial disease patterns, modelling of
disease distributions and spatial factors affecting disease spread (P20)
T3.8 Assess the burden of NZ borne by humans in selected case countries and the cost of NZ to livestock
production, valued in terms of DALYs & other economic indicators, and thereby total societal burden cost
assessment to form the basis for cost-effectiveness study of interventions which will be tested WP5-8. (P10)
T3.9 Assess prevalence of neglected zoonoses in animal hosts in case study areas in collaboration with WP4-10.
(P2,3,4,5,7,8,9,10,12,13,14,15,16,17,18,19,20,22)
3.1 Standardised methodology for quantifying the burden of NZ, including disease based disability weighting
factors for DALY developed from workshop outputs (M18)
3.2 Impact of NZ on livestock productivity losses (M54).
3.3. Gauged levels of underreporting of different surveillances systems and recommendations for risk-based
surveillance frame integrated in existing livestock and health services works at low cost and high
sensitivity/specificity (M60)
3.4 Main determinants of transmission between animals identified in case countries (M54).
3.5 Spatial dataset required for ICONZ objectives for all ICPCs (M24)
3.6 Livestock mapping tool available for use in case study area (M12)
3.7 Spatial analysis reports of disease distribution (as part of annual reports) and contribution to papers (M36-60)
3.8 Societal geo-referenced burden and cost of zoonoses assessed in case countries (M60)
3.9 Contribute to test new diagnostic tools and to assess cost-effectiveness of interventions in cooperation with
other WPs (M48)
29
FP7-KBBE-2007-1-3-09
Part B
ICONZ
WP4 IMPROVEMENT AND DEVELOPMENT OF DISEASE CONTROL TOOLS
Workpackage number
Workpackage title:
Activity Type:
Participant number
Participant number
Month 1
WP4
Improvement and development of disease control tools
RTD
1
UEDIN
7
14
UEM
2
3
ITM UCPH
22
4
15
16
NVRI- MAK
VOM
30
40
4
AFSSA
8
18
SUA
5
UCBL
40
19
UNZA
6
8
FLI
UNAV
50
25
21
LAB901
9
KI
20
12
LCV
24
13
IAVH2
33
40
30
12
Person-months per participant: 20
Objectives
1. To identify currently available disease control tools in relation to diagnosis, vaccination, treatment and policy
for each of the neglected zoonoses listed in the call.
2. To provide a detailed assessment of gaps in the disease control tools available.
3. To facilitate the development of new and improved tools.
4. To demonstrate the scientific validity of control tools for neglected zoonoses.
T4.1 Stakeholder workshop in collaboration with WP3, to identify the currently available control tools, to assess
the gaps and to identify new tools to be developed or existing tools to be improved. Attended by all relevant
ICONZ partners and stakeholders from ICPC countries (policy makers, veterinary services, farmers etc.) (P2).
T4.2 Based on the outcome of T4.1 research will be carried out to develop new and improved tools. Preliminary
partner consultation has identified a list of tools to be improved or to be developed, which will be discussed and
refined at the above mentioned workshop.
• Anthrax & brucellosis: quality assurance of local vaccines; Brucella ID and typing kit (P1,8,12,15,18)
• Tuberculosis: interferon gamma test, lateral flow immunochromatography& chip for fast screening (P6,9, 14, 18)
• Echinococcosis: ELISA antibody detection in sheep, recombinant vaccine against E. granulosus in dogs (P5,13)
• Leishmaniasis: rK39 immunochromatographic test (P2, 4, 13, 16)
• Rabies: direct rapid immunohistochemical test (P 1, 4, 18)
• Cysticercosis: pen-side test for detection of pigs with viable cysticerci , assessment of the efficacy and safety of
oxfendazole, diagnostic test for taeniosis (P2,3, 9,14, 18, 19)
• Trypanosomiasis (T.b.rhodesiense): ScreenTape™ electrophoresis system for classical PCR, adaptation of
existing PCR techniques to LAMP (Loop-mediated isothermal amplification)(P1,16,21).
T4.3 New and improved control tools will be validated under field conditions within the case studies in
appropriate ICPCs, planned in the work packages 5 to 8. Successful new tools will be introduced for uptake in the
local diagnostic reference laboratories in the ICPCs (P2,13,14,15,16,18,19).
4.1 A catalogue of currently available tools for each of the listed NZ as outputs from workshop, including gaps in
availability. For each of the available disease control tools detailed information will be given on its suitability for
different conditions prevailing in endemic developing countries (M12).
4.2 The following new or improved control tools (validated under laboratory conditions) will be available (this
list is a preliminary list to be adapted according to outcome of T4.1) (M24-36).
• Anthrax and brucellosis: quality assurance system for locally produced vaccines implemented (M36); Brucella
field identification and typing kit (M24).
• Tuberculosis: interferon gamma test, lateral flow immunochromatography and chip for fast screening (M36)
• Echinococcosis: ELISA for AB detection in sheep (M24), recombinant E. granulosus vaccine for dogs (M36)
• Rabies: direct rapid immunohistochemical test (M24).
• Cysticercosis: pen-side test for detection of pigs with viable cysticerci (M36), efficacy and safety of
oxfendazole assessed (M36), diagnostic test for taeniosis (M36).
• Trypanosomiasis (T.b.rhodesiense): existing PCR techniques adapted to LAMP format (Loop-mediated
isothermal amplification) (M24) and ScreenTape™ electrophoresis system developed (M24).
4.3 Field validated control tools for neglected zoonoses available (M60).
30
FP7-KBBE-2007-1-3-09
Part B
ICONZ
WP5 IMPROVE AND DEVELOP CONTROL AND PREVENTION
STRATEGIES … FOR NEGLECTED BACTERIAL ZOONOSES
Workpackage number
Workpackage title:
Month 1
WP5
Improve and develop control and prevention strategies through
integrated intervention packages for neglected bacterial zoonoses
RTD
Activity Type:
6
Participant number
FLI
7
UMINHO
25
8
UNAV
25
9
KI
15
10
STI
8
12
LCV
100
13
IAVH2
40
14
UEM
40
15
NVRI
50
16
MAK
30
17
SU
30
18
SUA
25
Objectives
1. To improve and develop control and prevention strategies for the neglected bacterial zoonosis cluster (anthrax,
bovine tuberculosis and brucellosis) in endemic developing countries, taking into account economic, sociological
and cultural aspects related to the diseases as well as traditional knowledge.
2. To develop cost-effective disease control strategies for anthrax, bovine tuberculosis and brucellosis.
3. To develop integrated disease control packages for the neglected bacterial zoonosis cluster.
4. To provide information for incorporation under WP11 into materials to be used in training and capacity
building activities.
5. To provide information for advocacy, and strategic options for control and prevention of neglected zoonoses to
be disseminated under WP12 to governments, technical assistance agencies (e.g. WHO, FAO) and donor bodies.
T5.1 Workshop in collaboration with WP6 to collect and collate information on current practices regarding
control & prophylactic measures against bacterial zoonoses including animal management, hygiene, food hygiene
and processing (with emphasis on milk pasteurisation), compile available information on their efficacy and
suitability for local communities & perform gap analysis on existing information and available options for control
and prevention of bacterial zoonoses, including availability and efficacy of vaccines (P6,7,8,9,10,12,13,14,15,16,18).
T.5.2 Formulate suitable integrated intervention strategies, by adapting identified variables (e.g. in the case of
brucellosis: mass or replacement vaccination; target species, vaccination route; vaccine strain; and the possible
losses due to cold-chain deficiency) to the variety of local conditions existing in the case study countries:
i) all brucellosis vaccination variables will be evaluated in the light of anthrax vaccination practices to determine
the actual possibilities (and most cost-effective strategy) to implement simultaneous immunizations (P8).
ii) development of bovine tuberculosis (BTB) control measures, by evaluation of uptake, sustainability and costs
of test and slaughter in areas with relatively low within-herd prevalences and where condemnation costs can be
reduced through good meat inspection, also testing improved diagnostics according to WP4 (P8).
iii) epidemiological modelling component to evaluate ways of utilising and/or improving existing tools/strategies
to identify and prevent high-risk situations for livestock infection including transmission from wildlife (P17).
T5.3 Pilot studies of the integrated control interventions derived from T5.1&T5.2 in selected case study areas
(Mali, Morocco, Mozambique, Nigeria, Uganda, Tanzania) (P12,13,14,15,16,18).
T5.4 Monitor impact of the integrated intervention strategies and analyse their cost-effectiveness in collaboration
with WP9 (Socio-economic and Institutional Aspects) (P6,7,8,9,10,12,13,14,15,16,18). .
T5.5 Produce materials for training and capacity building activities based on insights gained in T5.1-T5.6 (P8).
T5.6 Produce advocacy material and strategic options for control and prevention of NZ for dissemination (P8).
5.1 Report of inaugural workshop and resulting gap analysis (M12)
5.2 Improved control and prevention strategies for bacterial zoonoses based on combinations of individual
disease control tools optimised for use in particular situations (M24).
5.3 Operational research results supporting effectiveness, safety & impact of integrated control packages (M48).
5.4 Integrated cost-effective disease control packages addressing groups of related bacterial zoonoses targeting
specific human populations and their livestock (M54).
5.5 Materials for training and capacity building activities (M24-48).
5.6 Interim progress reports (M12, 30, 48, 60), advocacy material (M12) and strategic options for control and
prevention of NZ (M60) for dissemination.
31
FP7-KBBE-2007-1-3-09
Part B
ICONZ
WP 6 IMPROVE AND DEVELOP CONTROL AND PREVENTION
STRATEGIES … FOR DOG / SMALL RUMINANT-ASSOCIATED NZ
Workpackage number
Workpackage title:
Activity Type:
Participant number
Month 1
WP6
integrated intervention packages for dog / small ruminant-associated
neglected zoonoses
RTD
4
5
12
13
14
18
15
AFSSA
UCBL
LCV
IAVH2
UEM
NVRIVOM
SUA
60
38
24
50
10
10
30
Objectives
1. To improve and develop control and prevention strategies for the dog / small ruminant-associated neglected
zoonosis cluster (cystic echinococcosis, leishmaniasis and rabies) in endemic developing countries, taking into
account economic, sociological and cultural aspects related to the diseases as well as traditional knowledge.
2. To develop cost-effective disease control strategies for cystic echinococcosis, leishmaniasis and rabies.
3. To develop integrated disease control packages for the dog / small ruminant-associated zoonosis cluster.
be disseminated under WP12 to governments, technical assistance agencies (e.g. FAO, WHO, etc) and donors.
control and prevention of cystic echinococcosis, leishmaniasis and rabies including hygiene, sanitation, food
hygiene and processing as well as animal management (with emphasis on worming & vaccination), compile
available information on their efficacy and suitability for local communities and perform gap analysis on existing
information on the control and prevention of dog and small ruminant associated zoonoses (P4,5,13,18).
T6.2 Formulate suitable intervention strategies for local communities, taking into consideration differences
between i) traditional extensive sheep breeding in dry areas and ii) irrigated areas with semi-intensive bovine and
sheep breeding (including exotic breeds). Improved tools for the diagnosis and control of cystic echinococcosis
and rabies identified by WP4 will be adapted to local conditions and incorporated into a triple pronged approach
consisting of integration of worming & vaccination schedules for the respective host species in combination with
raising community awareness (based on insights from WP10). In endemic areas, leishmaniasis testing is also
integrated into T6.2 (using field tests evaluated by WP4) (P4).
T6.3 Pilot studies of the integrated control interventions derived from T6.1&T6.2 in selected case study areas
(Morocco and Northern Tanzania) (P4,5,13,18).
with WP9 (Socio-economic and Institutional Aspects) (P4,5,13,18)..
6.2 Improved control and prevention strategies for small ruminant and dog associated zoonoses based on
combinations of individual disease control tools optimised for use in particular situations (M24).
6.4 Integrated cost-effective disease control packages addressing groups of small ruminant and dog associated
zoonoses targeting specific human populations and their livestock (M54).
prevention of NZ (M60) for dissemination planning tools (M60).
32
FP7-KBBE-2007-1-3-09
Part B
ICONZ
STRATEGIES … FOR NEGLECTED PIG-ASSOCIATED PARASITIC
ZOONOSES
Workpackage number
Workpackage title:
Activity Type:
Participant number
Month 1
WP7
integrated intervention packages for neglected pig-associated parasitic
zoonoses
RTD
2
3
14
15
16
18
19
22
ITM
UCPH UEM
NVRI MAK
SUA UNZA
ILRI
4
6
60
30
34
30
70
12
Objectives
1.To improve and develop prevention and control strategies for the neglected pig-associated parasitic zoonosis
cluster (porcine cysticercosis, human neurocysticercosis and taeniosis) in endemic developing countries of Africa,
taking into account economic, sociological and cultural aspects of the diseases as well as traditional knowledge.
2.To develop cost-effective disease control strategies for cysticercosis and taeniosis.
3.To develop an integrated disease control package for the neglected pig-associated parasitic zoonosis cluster.
control and prevention of pig-associated parasitic zoonoses including animal management, hygiene, sanitation,
food hygiene and processing (with emphasis on meat inspection), compile available information on their efficacy
and suitability for local communities and perform gap analysis on existing information and available options for
the control and prevention of pig-associated parasitic zoonoses (P2,3,14,15,16,18,19,22).
T7.2 Upon filling the gaps regarding information, tools and control strategies a follow-up workshop involving
ICONZ, national, regional and international stakeholders will be held to reach a consensus and formulate an
affordable and sustainable “best bet” package of prevention and control interventions for cysticercosis and
taeniosis in African countries (P2,3,14,15,16,18,19,22).
T7.3 Pilot studies for testing and validating the “best bet” integrated control package for pig-associated zoonoses
derived from T7.1-7.2, conducted in the cysticercosis endemic ICPC countries (P2,3,14,15,16,18,19,).
with WP9 (Socio-economic and Institutional Aspects) (P2,3,14,15,16,18,19).
7.2 Improved control and prevention strategies for pig-associated parasitic zoonoses based on combinations of
individual disease control tools optimised for use in particular situations (M24).
7.4 Integrated cost-effective disease control packages addressing groups of pig-associated parasitic zoonoses
targeting specific human populations and their livestock (M54).
33
FP7-KBBE-2007-1-3-09
Part B
ICONZ
STRATEGIES … FOR NEGLECTED VECTOR-BORNE ZOONOSES
Workpackage number
Workpackage title:
Activity Type:
Participant number
Month 1
WP8
integrated intervention packages for neglected vector-borne zoonoses
RTD
1
UEDIN
2
14
UEM
29
15
NVRI-VOM
28
16
MAK
70
17
SU
30
18
SUA
25
19
UNZA
48
Objectives
1. To improve and develop prevention and control strategies for zoonotic trypanosomiasis, tick-borne animal
diseases and malaria (in some areas) in endemic developing countries of Africa, taking into account economic,
sociological and cultural aspects related to the diseases as well as traditional knowledge.
2. To develop cost-effective disease control strategies for zoonotic trypanosomiasis, tick-borne animal diseases
and malaria (in some areas).
3. To develop an integrated disease control package for zoonotic trypanosomiasis, tick-borne animal diseases and
malaria (in some areas).
control and prophylactic measures against vector-borne diseases including animal management, chemotherapy
and vector control, compile information on their efficacy & suitability for local communities & perform gap
analysis on existing information & available options for control & prevention of vector-borne diseases (P1,16,17).
T8.2 Formulate suitable integrated intervention strategies, by adapting identified variables to the variety of local
conditions existing in the case study countries:
i) Compare the efficacy of two approaches for the control of zoonotic trypanosomiasis: synchronous block
treatment of the cattle population of an intervention area (top-down) versus a-synchronous market-driven farmer
treatment of individual animals or herds (bottom-up) and develop epidemiological model (P1,16,17).
ii) Assess collateral benefits of application of synthetic pyrethroid to cattle, on the tsetse vector and trypanosome
infection prevalence of cattle and other livestock and/or wildlife impacting in the adjacent areas (P1,16,17,18)
iii) Assess the broader animal health benefits of application of synthetic pyrethroid to cattle by concurrent control
of tsetse and tick-borne diseases and assess the broader human health benefits by potential knock-on effects on
mosquito populations and on malaria transmission (household and village level) (P1,16,17).
T8.3 Pilot studies of the integrated control interventions derived in T5.1&T5.2 in Uganda & Tanzania (P16,18).
T8.4 Monitor the impact of the different intervention strategies trialed in Uganda and Northern Tanzania and
analyse their cost-effectiveness in collaboration with WP9 (Socio-economic and Institutional Aspects).
T8.6 Produce advocacy material and strategic options for control and prevention of NZ for dissemination (P1,16).
8.2 Improved control and prevention strategies for vector-borne diseases based on combinations of individual
disease control tools optimised for use in particular situations (M24).
8.4 Integrated cost-effective disease control packages addressing groups of vector-borne diseases targeting
specific human populations and their livestock (M54).
34
FP7-KBBE-2007-1-3-09
Part B
ICONZ
WP9 SOCIO-ECONOMIC AND INSTITUTIONAL ASPECTS
Workpackage number
WP9
Workpackage title:
Socio-economic and institutional aspects
Activity Type:
RTD
3
10
12
13
14
15
16
Participant number
UCPH STI
LCV IAVH2 UEM
NVRI
MAK
3
40
33
39
40
40
Month 1
18
SUA
38
19
UNZA
40
20
Avia-GIS
15
Objectives
1. To collect existing information and data on the cost-effectiveness of various control strategies for each of the
neglected zoonoses under consideration by ICONZ.
2. To set up activities with ICPC participants in ICONZ to fill knowledge gaps on cost-effectiveness of control
strategies for neglected zoonoses.
3. To analyse the cost-effectiveness of integrated intervention packages being tested and validated under WPs 58 for each of the neglected zoonoses clusters.
4. To formulate recommendations as to appropriate medical/veterinary structures, liaison and cost-sharing for
the effective control of NZs.
5. To provide overarching support to other WPs, especially WPs5-8 & WP10, in socio-economic and
institutional matters.
6. To harmonise with WPs 3 & 5-10 in providing training materials be taken up by WP11 and to provide
information for advocacy to be disseminated by WP12.
T9.1 WP leader to attend inaugural workshops of WP3&4, 5&6 and 7&8, for overarching support on socioeconomic and institutional aspects.
T9.2 Workshop in collaboration with WP10 to inventory and analyse existing information on the costeffectiveness of different approaches for controlling theses neglected zoonoses (NZs) and liaise with WP3 on
collecting the information available on the total societal cost of different NZs (P3,10,12,13,14,15,16,18,19,20).
T9.3 Set out standardised protocols for collecting and analysing data on the socio-economic aspects of NZs
(burden on livestock and human health, costs of control) together with WP3 (P10,20).
T9.4 Identify gaps and initiate necessary data collection in the ICPCs to fill these gaps. Supervise/undertake this
data collection, together with WP3(P3,10,12,13,14,15,16,18,19,20).
T9.5 Inventory and analyse the structures and organisations involved in controlling NZs in Africa. Identify
strengths and weaknesses of these structures, and, liaising with ICPCs, make recommendations as to the most
appropriate structures for supporting the effective control of NZs (P3,10,12,13, 14,15,16,18,19,20).
T9.6 Examine how the costs of controlling NZs could best be allocated between the various medical and
veterinary groups so as to optimise their effective control, whilst distributing the costs equitably between the two
sectors, to reflect the way the dual burden of these NZ falls on human & livestock health (P10,20).
9.1 Expert advise on socio-economic and institutional aspects at inaugural workshops (M12)
9.2 Data collection checklists and protocols for analysing the costs of the different control strategies for the NZs
in the study from workshop output (M18).
9.3 Comparative analysis of costs of different control methods for each of the NZ clusters in the study (M54).
9.4 Together with WP3, calculation of cost-effectiveness of different strategies for controlling NZs (M60).
9.5 Guidelines and recommendations for cost-sharing arrangements between medical and veterinary sectors
(M60).
9.6 Guidelines and recommendations for liaison and structuring organisational and institutional links between the
various groups responsible for controlling NZs (M60).
9.7 Together with other WP3, provision of background information on which to base advocacy and dissemination
activities under WP12 (M60).
35
FP7-KBBE-2007-1-3-09
Part B
ICONZ
WP10 CULTURAL ASPECTS, GENDER ISSUES, TRADITIONAL
KNOWLEDGE AND MESSAGING IN THE CONTROL OF NZ
Workpackage number
Workpackage title:
Activity Type:
Participant number
Month 1
WP10
Cultural aspects, gender issues, traditional knowledge and messaging in
the control of neglected zoonoses
RTD
3
UCPH
1
6
FLI
12
10
STI
3
12
LCV
41
13
IAVH2
33
14
UEM
40
15
NVRI
41
16
MAK
41
18
SUA
60
19
UNZA
41
Objectives
1. To establish current knowledge, attitudes and practices with regards to the presence, transmission factors,
impact, and control of neglected zoonoses in the case-study area.
2. To characterise and facilitate the role of women in relation to the control of neglected zoonoses, not just as
direct beneficiaries from improved livestock and human health, but also in terms of their key role in the success of
local control programmes.
3. To review existing messaging tools in all media that are used to support disease control activities for the
neglected disease clusters addressed by ICONZ.
4. To identify appropriate tools and channels to reach target communities and affect health behaviour and
environmental factors.
5. To create health messaging tool kits for strategic scenario-diagnosis, planning and targeting and monitoring of
public health interventions, including a central repository for field-tested messaging material.
6. To provide overarching support to other WPs, especially WPs5–8 & WP9, on gender issues, use of appropriate
messaging and adaptation of control strategies to local cultural contexts.
T10.1 WP leader to attend inaugural workshops of WP3&4, 5&6 and 7&8, for overarching support on cultural
aspects, gender issues, traditional knowledge and messaging.
T10.2 Workshop in collaboration with WP9 to collect and collate existing information on the knowledge, attitudes
and practices with regards to the presence, transmission factors, impact, and control of neglected zoonoses in the
ICPC case-study areas (P3,6,10,12,14,15,16,18,19).
T10.3 Workshop with relevant stakeholder for WP5-8 to collect and collate existing information on role of women
in relation to the control of neglected zoonoses and as beneficiaries (P3,6,10,12,14,15,16,18,19).
T10.4Undertake review of all existing messaging tools used to support diseases control activities for neglected
zoonoses to look for complimentary of approach and integrated design (P12,14,15,16,18,19).
T10.5 To survey appropriate channels of communicating integrated health messaging appropriate to culture and
setting and environment (P12,14,15,16,18,19).
T10.6 To use the PRECEDE-PROCEED planning model to develop appropriate public health messaging options
for each neglected zoonosis by identifying environmental and behavioural risk factors of high importance and
changeability. Having planned the interventions for all the diseases, opportunities for integrated approach for
their control will be utilized based on similarities of their control measures (P12,14,15,16,18,19).
T10.7 A central resource accessible for policy makers and public health personnel will be created to facilitate
systematic planning, implementation and evaluation of public health interventions (including repository of
successful messaging material) (P18).
10.1 Expert advise on cultural aspects, gender issues, traditional knowledge, messaging at WP-workshops (M12)
10.2 Defined current knowledge attitudes and practices for the presence, transmission factors, impact, and control
of neglected zoonoses in the ICPC case-study areas from workshop outputs (M12).
10.3 Role of women in the control of zoonoses defined at all levels of engagement (M12).
10.4 All available messaging tools identified (M24).
10.5 Channels for communication of zoonoses messages identified (M24).
10.6 Health message tool kits developed and trialed for disease clusters WP5 to 8 (M36-48).
10.7 Repository for messaging materials established and shared with policy makers & field practitioners (M60).
36
FP7-KBBE-2007-1-3-09
Part B
ICONZ
WP11 CAPACITY BUILDING THROUGH TECHNOLOGY TRANSFER AND
TRAINING
Month 1
Workpackage number
WP11
Workpackage title:
Capacity building through technology transfer and training
Activity Type:
Other
1
3
4
7
8
9
12
13
14
Participant number
UEDIN
UCPH
AFSSA
UMINHO
UNAV
KI
LCV
IAVH2
UEM
36
12
20
12
10
35
28
35
15
16
17
18
19
20
22
Participant number
NVRI
MAK
SU
SUA
UNZA
AVIA-GIS
ILRI
44
23
35
35
3
6
Objectives
1. To build diagnostic, prevention and control capacity for neglected zoonoses in targeted African countries.
2. To train individual scientists, medics, veterinarians and other appropriate personnel within the human health
and livestock production sectors in diagnosis, epidemiology, prevention and control of neglected zoonoses.
3. To provide training packages on prevention and control of neglected zoonoses at community level to medical,
veterinary and agricultural personnel as well as community leaders, livestock keepers and householders, with
particular regard to the importance of the role of women.
T11.1 Questionnaire surveys will be conducted at all partner institutes and with other relevant stakeholders (in
collaboration with WP2). The survey will be addressing needs for capacity building, opportunities and available
training options with regards to prevention and control of neglected zoonoses. The questionnaire will address all
four capacity building capitals (human, managerial, tangible and social), but main focus will be put on the human
capital (P3,12,13,14,15,16,17,18,19,22).
T11.2 Based on outcome of T11.1 scientific training programmes will be developed and implemented at relevant
partner institutions for appropriate participants. Teachers with specific knowledge will be recruited from partners
and outside as needed. Training topics will include diagnosis, epidemiology and control of neglected zoonoses,
basic qualitative and quantitative research methodology, research ethics as well as any other identified training
need (P1,3,4,7,8,9,12,13,14,15,16,17,18,19,22).
T11.3 An electronic flexible distance learning course based on the material provided by the pig-associated
parasite package (WP5) for different target audiences will be produced and evaluated as a model for the other
neglected zoonoses. The course material will be computer based but produced on discs to be independent of
internet access. It will contain training modules for both lay people and scientist. Similar modules can be
facilitated for the other three disease control packages (bacterial zoonoses, dog-small ruminant associated, vectorborne disease) in collaboration with WP6-8 (P1,3,4,7,8,9,12,13,14,15,16,17,18,19,22).
T11.4 To develop tailored distance learning exercises using relevant ICONZ data sets for ICONZ partners
subscribing to the GIS-Epidemiology module at the Faculty of Veterinary Science, Onderstepoort, RSA (P20).
T11.5 Community-level training programme “toolkits” for the 4 disease control and prevention strategies
packages will be developed in collaboration with partners of WP5-8. Based on the outcome of WP5, the ‘toolkits’
will include simple instructions for prevention and control of neglected zoonoses for each of the packages
described in WP5. (The impact of “tool kits” will be assessed in WP5-8). (P3,12,13,14,15,16,17,18,19,22).
11.1 Inventory of currently available relevant training courses at local, regional and international levels (M12)
and needs and opportunities assessment on national/institutional capacity building from African partner institutes
(M12)
11.2 At least 4 research training programmes on diagnosis, epidemiology, prevention and control of NZ
conducted (M18, M24, M30, M36)
11.3 Electronic-learning module on prevention and control of zoonoses clusters for different target groups
produced (M36 -60).
11.4 Tailored distance learning exercises using relevant ICONZ data for GIS-Epidemiology module (M36-60).
11.5 Community level training programme “toolkits” for each of the 4 disease control and prevention strategies
packages produced (M42)
37
FP7-KBBE-2007-1-3-09
Part B
ICONZ
WP12 COMMUNICATION AND DISSEMINATION
Month 1
Workpackage number
WP12
Workpackage title:
Communication and dissemination
Activity Type:
Other
1
4
8
12
13
14
15
16
17
Participant number
UEDIN
AFSSA
UNAV
LCV
IAVH2 UEM
NVRI
MAK
SU
2
2
46
37
45
46
90
15
18
19
20
22
Participant number
SUA
UNZA AVIA-GIS ILRI
46
6
6
Objectives
1. To secure the commitment of governments and donor bodies to control neglected zoonoses.
2. To ensure effective communication among all stakeholders within and outwith ICONZ, through publications,
reports, meetings and workshops.
3. To promote the establishment and acceptance and support the activities of the Scientific Advisory Committee
for Neglected Zoonoses.
4. To maximise the impact of the research investment by improving the availability of information on all aspects
of neglected zoonoses covered by this project and by disseminating the project results by means of guidelines,
tools, workshops, learning materials, policy briefings and research publications.
T12.1 Written agreement by all partners (at first consortium meeting) regarding data sharing, rights for
dissemination of data and tools, acknowledgement and publication policy and joint authorship arrangements (P1).
T12.2. Design and maintenance of the ICONZ web-site, providing project updates, advocacy materials and links
to all project publications (P1).
T12.3 Develop and implement a centralized web-based data archive linked to the ICONZ website (P20).
T12.4 Publication of a bi-annual ICONZ newsletter, to include progress reports of all workpackages (WPs) (P1)
T12.5 Co-ordination of project planning and research dissemination meetings including the annual project coordination meeting, stakeholder forum in conjunction with WP1, inaugural workshops between European and
African partners for WP3&4, 5&6, 7&8, joint meetings with the WHO Zoonoses Working Group and other
health service policy external consultative groups, such as the Scientific Advisory Committee for NZ (P1)
T12.6 Co-ordination of ICONZ publications including workshop reports, guidelines for control and prevention of
neglected zoonoses (best practice and newly developed control tools and strategies), advocacy materials,
summaries of knowledge and scientific publications) (P1,4,8,12,13,14,15,16,17,18,19,20,22).
T12.7 Co-ordination with national stakeholders and policy makers as recipients of new knowledge generated by
the project, including Ministries of Health and Ministries of Livestock and Agriculture in all ICPS, by inclusion
of officials in stakeholder workshops and joint meetings (P1).
T12.8 Media engagement in European & African partner countries, to raise public awareness and create political
and donor interest for the importance of controlling neglected zoonoses in achieving the Millenium Goals(P1).
T12.9 Co-ordination and close collaboration with global partners in zoonotic disease control such as EFSA,
WHO, OIE, FAO, ILRI, ASARECA, AU-IBAR etc., by invitation of representatives to research planning and
dissemination meetings (P1,4,8,12,13,14,15,16,17,18,19,20,22).
12.1 Policy-makers appraised of importance of NZ including burdens and cost in humans & animals (continuous)
12.2 Active website, including online stakeholder forum (M6)
12.3 Operational ICONZ data archive (M24)
12.4 Bi-annual ICONZ newsletter (M6 & every 6months hereafter)
12.5 Reports of inaugural and annual ICONZ project co-ordination meetings (M3 & every 12 months hereafter)
12.6 Report series of guidelines for control and prevention of individual NZ and NZ clusters (completed by M60)
12.7 National reports for all ICPC, appraising control options and policy implications (delivery of specific
advocacy materials, national reports on current zoonoses, policy implications & cost-effectiveness of
interventions, provision of project data for planning of public health interventions) (M 48)
12.8 Media engagement (continuous)
12.9 Scientific publication in form of individual research papers and dedicated journal issues (continuous).
38
FP7-KBBE-2007-1-3-09
B1.3(vi)
Part B
ICONZ
EFFORTS FOR THE FULL DURATION OF THE PROJECT
No
PARTNER
WP1
WP2
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
UEDIN
ITM
UCPH
AFSSA
UCBL
FLI
UMINHO
UNAV
KI
STI
ULIV
LCV
IAVH2
UEM
NVRI-VOM
MAK
SU
SUA
UNZA
AVIA-GIS
LAB901
ILRI
Total
50
2
2
2
1
WP4
2
1
5
11
7
22
4
8
40
50
15
6
15
50
2
2
2
WP3
29
10
8
10
10
10
2
10
10
2
50
41
50
50
50
20
40
50
24
127
6
486
21
21
21
25
20
24
33
20
30
40
40
30
WP5
WP6
WP7
WP8
WP9
WP10
2
4
6
1
1
60
38
12
25
25
15
8
100
40
40
50
35
30
25
WP11
WP12
Total
10
32
36
12
2
102
30
51
89
89
74
60
72
60
66
31
370
303
399
370
475
120
399
370
50
12
30
3622
12
24
50
10
10
30
60
30
34
30
70
29
28
70
30
25
48
3
3
40
33
39
40
40
41
33
40
41
41
38
40
15
60
41
20
12
10
2
35
28
35
35
44
23
35
35
3
46
37
45
46
90
15
45
46
6
6
379
6
418
12
100
405
39
405
222
12
246
232
289
313
FP7-KBBE-2007-1-3-09
Part B
ICONZ
Project Effort Form 2 - indicative efforts per activity type per beneficiary (Beneficiaries 1-11)
Project number (acronym): 221948 (ICONZ)
Activity
UEDIN
ITM
UCPH
AFFSA
UCBL
2
1
5
11
22
4
8
40
FLI
UMINHO
UNAV
KI
STI
15
6
15
25
20
25
15
ULIV
…
TOTAL
RTD/Innovation activities
WP3
WP4
7
WP5
12
WP6
60
WP7
WP8
4
25
486
405
8
405
38
222
6
246
2
232
WP9
1
WP10
Total 'research'
50
50
3
1
12
89
74
40
56
50
289
3
313
64
2598
9
28
13
73
WP1
50
2
2
2
2
2
2
127
Total 'management'
50
2
2
2
2
2
2
127
29
100
Demonstration activities
Total 'demonstration'
Consortium management activities
Other activities
WP2
1
WP11
10
WP12
32
Total 'other'
43
TOTAL BENEFICIARIES
102
40
36
12
20
2
30
36
14
51
89
12
10
379
2
89
74
418
20
14
10
60
72
60
66
29
897
31
3622
FP7-KBBE-2007-1-3-09
Part B
ICONZ
Project Effort Form 2 - indicative efforts per activity type per beneficiary (Beneficiaries 12-22)
Project number (acronym): 221948 (ICONZ)
Activity
…
LCV
IAHV2
UEM
NVRI-VOM
MAK
SU
SUA
UNZA
AVIA-GIS
24
LAB901
ILRI
TOTAL
RTD/Innovation activities
WP3
50
41
50
50
50
WP4
24
33
20
30
40
WP5
100
40
40
50
35
WP6
24
50
10
10
60
30
WP7
WP8
WP9
40
33
20
40
50
40
30
30
25
6
12
405
405
30
34
29
28
70
39
40
40
WP10
41
33
40
41
41
Total 'research'
279
230
288
279
310
30
30
80
486
222
70
25
48
38
40
60
41
288
279
12
246
232
15
289
313
39
12
18
2598
Demonstration activities
Total 'demonstration'
Consortium management activities
WP1
21
21
21
2
127
Total 'management'
21
21
21
2
127
Other activities
WP2
10
8
10
10
10
2
10
10
WP11
35
28
35
35
44
23
35
35
3
6
379
WP12
46
37
45
46
90
15
45
46
6
6
418
Total 'other'
91
73
90
91
144
40
90
91
9
12
897
TOTAL BENEFICIARIES
370
303
399
370
475
120
399
370
50
30
3622
41
100
12
FP7-KBBE-2007-1-3-09
Part B
ICONZ
B1.3(vii) LIST OF MILESTONES AND PLANNING OF REVIEWS
List of milestones
Milestone
no.
Milestone name
WP
No’s.
Lead
Beneficiary
Delivery
date
1.1
1.2
Management board
Advisory Council
1
1
1
1
M3
M6
1.3
1.4
Stakeholder forum
Interim financial & scientific
reports
Final scientific report
Database mapping global
research
Gap analysis of global research
1
1
1
1
1
2
1
11
M6
M12, 30,
48, 60
M60
M27
2
11
M36
Standardised method of
quantifying burden
Impact on livestock productivity
3
10
M18
3
10
M54
3
10
M60
3
10
M54
4
2
M12
4
2
M36
4,5-8
2
M60
Gap analysis of strategies for
bacterial zoonoses
Improved integrated strategies
for bacterial zoonoses
5
8
M12
5
8
M24
5.3
Operational research results for
bacterial zoonoses
5
8
M454
6.1
dog/ small ruminant-associated
zoonoses
Improved strategies for dog/
small ruminant-associated
zoonoses
dog/ small zoonoses
6
4
M12
6
4
M24
6
4
M54
1.5
2.1
2.2
3.1
3.2
3.3
3.4
4.1
4.2
4.3
5.1
5.2
6.2
6.3
Estimate of level of underreporting
Main determinants of
transmission
Gap analysis of NZ control
tools
Laboratory validation of control
tools
Field validation of control tools
42
Comments
Management board established
Advisory Council (Steering Group)
established
Stakeholder forum established
Interim financial and scientific reports
charting progress of ICONZ
Final scientific report
Database mapping global research in NZ
populated and active
Gap analysis of global research on NZ
completed
Standardised method of quantifying burden
of NZ established
Established impact of NZ on livestock
productivity
Estimate of level of under-reporting of NZ
Main determinants of transmission of NZ
between animal hosts identified
Gap analysis of NZ control tools
Laboratory validation of new/improved NZ
control tools
Field validation of new/improved NZ control
tools
Gap analysis of control and prevention
strategies for neglected bacterial zoonoses
Formulation of improved integrated control
and prevention strategies for neglected
bacterial zoonoses
Operational research results validating
efficacy and cost-effectiveness of improved
integrated control and prevention strategies
for neglected bacterial zoonoses
strategies for dog/ small ruminant-associated
neglected zoonoses
and prevention strategies for dog/ small
ruminant-associated neglected zoonoses
for neglected pig-associated parasitic
zoonoses
FP7-KBBE-2007-1-3-09
Part B
ICONZ
List of milestones (continued)
Milestone
no.
WP
No’s.
Lead
Beneficiary
Delivery
date
Comments
pig-associated parasitic
zoonoses
Improved strategies for pigassociated parasitic zoonoses
7
14
M12
7
14
M24
7.3
pig-associated parasitic
zoonoses
7
14
M54
8.1
vector-borne zoonoses
8
16
M12
8.2
Improved strategies for vectorborne zoonoses
8
16
M24
8.3
8
16
M54
9.1
Standardisation of socioeconomic data
Guidelines and
recommendations for public
health and veterinary systems
9
20
M18
9
20
M60
10.1
KAP for control of NZ and role
of women
10
18
M12
10.2
Identification of messaging
materials and channels for
interventions
Health messaging tool kits
10
18
M24
10
18
M60
Gap analysis of training for
control
Community level training
programme toolkits
Pig training programme for
control
Policy makers appraised
11
3
M12
11
3
M42,
11
3
M48
12
1
12
12
1
1
M12, 30,
48, 60
M6
M24
strategies for neglected pig-associated
parasitic zoonoses
and prevention strategies for neglected pigassociated parasitic zoonoses
for neglected pig-associated parasitic
zoonoses
strategies for neglected vector-borne
zoonoses
and prevention strategies for neglected
for neglected vector-borne zoonoses
Standardisation of collection of socioeconomic data
Guidelines and recommendations for efficient
collaboration and cost-sharing between
public health and veterinary systems to
control NZ
Assessment of current knowledge, attitudes
and practices with respect to control of NZ
and assessment of the role of women in the
control of NZ
Identification of available messaging
materials and appropriate messaging
channels for public health NZ interventions
Health messaging tool kits for NZ developed,
field tested and available to policy makers
and public health personnel in central data
repository
Gap analysis of available training for control
of NZ
Community level training programme toolkits
for the control of NZ available
Pig training programme for the control of NZ
available
Policy makers appraised of importance of NZ
12
1
7.1
7.2
9.2
10.3
11.1
11.2
11.3
12.1
12.2
12.3
12.4
Milestone name
Active ICONZ website
Operational ICONZ data
archive
Scientific publications
43
M12, 30,
48, 60
Active ICONZ website
Operational ICONZ data archive
Scientific publications (individual research
papers and dedicated journal issues)
FP7-KBBE-2007-1-3-09
Part B
ICONZ
Planning of reviews
Tentative schedule of project reviews
Review
no.
1
Planned venue
of review
Edinburgh
Tentative timing
After project month: 30
44
Comments , if any
FP7-KBBE-2007-1-3-09
Part B
ICONZ
B2. Implementation
B2.1. Management structure and procedures
ICONZ will be broken down into the work packages described in section B1. A major work
package will be devoted to project management and coordination and a flexible but
comprehensive management and advisory structure will be developed to take into account the
needs of the different participating groups. Management of the project will be directed by a
Management Board comprising the Coordinator and work package leaders. The Management
Board will be guided by an Advisory Council (Steering Group) comprising key stakeholder
group representatives, supplemented by observers. General day-to-day organisation of
ICONZ will be conducted by a Secretariat comprising the coordinator and an executive
assistant based in Edinburgh. The project management and coordination activities will be
undertaken in close association with the activities to be conducted under WP12,
COMMUNICATION AND DISSEMINATION. The establishment of a Stakeholder Forum and
Mirror Groups in the ICPCs will be the responsibility of WP12, with support from WP1. The
project management and coordination secretariat will assist with the organisation of ICONZ
project Workshops, in collaboration with the various workpackage leaders. Finally, the
project management and coordination secretariat will take responsibility for scientific and
financial reporting to the Commission.
The implementation of this work package will lead to: a) An appropriate governance structure;
b) Establishment of a Management Board (Coordinator & WP Leaders);
c) Establishment of an Advisory Council (Steering Group) comprising key stakeholder group
representatives & observers;
d) Interim Reports (month 12, 24, 36, 48 etc.) ; and
e) Final Report – Scientific.
MANAGEMENT BOARD
A board consisting of a maximum of 12 representatives will be established to support the
coordinator and agree the way forward for the project. The board will comprise the ICONZ
Coordinator and leaders of the other 11 work package. There will also be observers from the
relevant Commission DG as appropriate. The activities of the ICONZ Management Board
will be:•
•
•
•
•
•
•
To review and monitor the entire programme
To decide on strategies within the framework of the project
To develop the strategies for the exploitation and dissemination of information from the
project
To receive recommendations from the Scientific Advisory Council
To accept responsibility to run the workshops, chairing meetings and identifying, on the
advice of the Scientific Advisory Council, the participants at the workshops
To provide regular statements on the implementation of the activities of the Project
To approve all detailed and provisional budgets.
The ICONZ Management Board will meet quarterly or more frequently if necessary.
Meetings will be face to face at least once a year but more generally by teleconference. The
project co-ordinator will chair the meetings.
SCIENTIFIC ADVISORY COUNCIL
The Scientific Advisory Council is at the core of ICONZ. The Scientific Advisory Council
will be available to advise on technical, financial, administrative and dissemination issues. It
45
FP7-KBBE-2007-1-3-09
Part B
ICONZ
will meet physically on three occasions during the life of the project and will be asked for
advice on a range of issues. Other methods of communication, in particular teleconferences,
will be used as appropriate. It is also envisaged that the Advisory Council will endorse the
outputs of the project. For the successful outcome of the project, it is essential that the
Scientific Advisory Council which represents all the main stakeholders should endorse the
recommendations and output from this project.
The Scientific Advisory Council is a network connecting the project to the major stakeholders
and the pool of ideas. The Scientific Advisory Council will oversee the project in an advisory
capacity and will act to move the project forward. It will be the main point of contact for all
other stakeholders. The role of the Scientific Advisory Council will be:•
To assist in the development of the project
•
To assist in the development of the work packages, chairing groups as necessary
•
To improve information sharing and coordination between the stakeholders
•
To support and provide expertise for specific expert and working groups
•
To ensure active involvement of the ICPCs, EU Member States, European institutions and
other organisations
•
To organise activities as necessary.
• To identify appropriate additional funding from public or private sources.
In order to create an efficient organisation, the Scientific Advisory Council will consist of 5
members drawn from key stakeholders groups. Membership of the Council will be balanced
and there will be representation from the main stakeholder groups; because of the breadth of
the topic it is possible that not all minor stakeholders will be on the Advisory Council.
Scientific Advisory Council representatives may be drawn from: •
Academia: representatives of the European research community from the Universities
•
Research institutions
•
Industry: e.g. agriculture. biotechnology, animal health, diagnostics
•
SMEs
•
Related interest groups, veterinary profession, specialist groups
•
Chief Veterinary and Medical Officers in ICPCs
•
International organisations
• Networks of Excellence
Supplementing the Scientific Advisory Council will be a number of observers; for this group
a number of regional and international bodies will be invited to nominate representatives,
including:•
Relevant services of the EC (e.g. RTD, DEV, SANCO)
•
ECDC
•
ETPGAH
•
EFSA
•
WHO
•
FAO
•
OIE
46
FP7-KBBE-2007-1-3-09
Part B
•
ASARECA
•
AU-IBAR, etc; (see Appendix I. List of abbreviations).
ICONZ
THE SECRETARIAT
An essential element supporting ICONZ project will be the project secretariat. The secretariat
will deal with the administrative matters of organising and running the day-to-day
arrangements for the large collaborative project. The ICONZ secretariat will consist of the
Coordinator to run the project supported by an executive assistant. The responsibilities of the
secretariat will be:•
•
•
•
•
•
General organisation of the ICONZ collaborative project including progress and
milestones meetings
Organisation of workshops in cooperation with workpackage leaders, although those
should bear the responsibility for the workshop programme and content
Guarantee smooth flow of information between participants, the ICONZ Management
Board and the Scientific Advisory Council
Receive and allocate the grant from the Commission
Overall Budget responsibility, refunding in agreement and under the control of the
ICONZ Management Board
Assist in reporting to the European Commission
STAKEHOLDER WORKSHOPS
Key to the coordination of the project will be regular stakeholder workshops for the benefit of
the consortium partners and associated groups. Existing stakeholders networks in the various
neglected zoonoses targeted in the call will be utilised and supported. Examples of these
networks include CWGESA, EchinoNet, ETPGAH, ICPTV, MED-VET-NET, MZCP,
SWGL, and GCCC; (see Appendix I. List of abbreviations). Individual kick-off workshops
will be conducted for each of the three vertical scientific integration themes B–D, comprising
work packages 3–10, namely THEME B, DIAGNOSIS, BURDEN & CONTROL TOOLS, THEME C,
CONTROL & PREVENTION STRATEGIES: INTEGRATED INTERVENTION PACKAGES (2 workshops)
and THEME D, OVERARCHING SUPPORT MEASURES: ECONOMIC, SOCIOLOGICAL & CULTURAL
ASPECTS. Hence under THEME B, the introductory workshop will cover the topics of WP3,
KNOWLEDGE & INFORMATION ON NEGLECTED ZOONOSES and WP4, IMPROVEMENT &
DEVELOPMENT OF DISEASE CONTROL TOOLS. Under THEME C, two introductory workshops
will be held, one addressing WP5 BACTERIAL ZOONOSIS CLUSTER and WP6 SMALL RUMINANT /
DOG- ASSOCIATED ZOONOSIS CLUSTER and another to address WP7, PIG-ASSOCIATED
PARASITE CLUSTER and WP8, VECTOR-BORNE ZOONOSIS CLUSTER. Under THEME D, the
introductory workshop will address WP9, SOCIOECONOMIC & INSTITUTIONAL ASPECTS OF THE
CONTROL OF NEGLECTED ZOONOSES and WP10, CULTURAL ASPECTS, GENDER ISSUES,
TRADITIONAL KNOWLEDGE AND MESSAGING IN THE CONTROL OF NEGLECTED ZOONOSES.
These workshops will be held consecutively, enabling participants contributing to more than
theme to engage fully with the process.
REPORTING
The ICONZ Coordinator and secretariat will have responsibility to the Commission for timely
submission of interim scientific and financial reports and for the final scientific report at the
end of the ICONZ project cycle.
B2.2. Beneficiaries
See following pages:-
47
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 1: UNIVERSITY OF EDINBURGH (UEDIN), UK
The University of Edinburgh is one of the largest (26,000 students, 8000 staff) and most
successful research universities in the UK with an international reputation as a centre of
academic excellence. The College of Medicine and Veterinary Medicine (CMVM) aims to
produce leading edge, internationally recognised research and teaching.
Within the Centre for Infectious Diseases (CID), which integrates all research disciplines
within the University of Edinburgh working on infectious diseases (bacteriology, virology,
epidemiology, immunology & infection, pathway medicine, medical microbiology, medical
sciences and veterinary clinical studies), the Centre for Tropical Veterinary Medicine
(CTVM) is a leading partner in longstanding research on the integrated control of neglected
zoonoses including trypanosomiasis, brucellosis and rabies. The University of Edinburgh
brings substantial capabilities and expertise in project coordination to the ICONZ consortium,
with vast experience in large collaborative activities between CMVM and African centres e.g.
Cameroon: Control of Onchocerciasis; Uganda: 'Stamp Out Sleeping Sickness’ public-private
partnership; The Gambia: prospective case control molecular profiling studies; Kenya:
Infectious Diseases of East African Livestock; Malawi: e-learning for capacity for healthcare
professional education; primary care development; Pan sub-Saharan Africa: African
Universities Veterinary e-learning Consortium (AUVEC); Alliance for Rabies Control.
SCIENTIFIC LEADER
Mark Charles Eisler, BA, Vet MB, MSc, PhD, MRCVS, Head of Section of Animal Health
and Veterinary Public Health, Diplomate of the European Veterinary Parasitology College, is
a veterinary epidemiologist based at the CTVM, UEDIN, with > 20 years of experience in
international animal health and the epidemiology of endemic infectious diseases of cattle in
the tropics including tick-borne diseases, trypanosomiasis, cysticercosis, brucellosis,
echinococcosis. Research focus: infectious diseases in multi-host communities, risk factors
for disease emergence, true burden of disease in human & livestock populations and
optimization of zoonotic disease control. Under pervious EU Framework Programmes, Mark
has been Coordinator of the ICPTV Concerted Action and other Collaborative Research
Projects on trypanosomiasis, & participant in a number of other EU –funded projects.
KEY PERSONNEL
Prof. Sue C. Welburn, Professor of Molecular Epidemiology, based at the CTVM, UEDIN,
UK. Over the past 20 years, her research work has been centered on the epidemiology of
human sleeping sickness and interactions at the trypanosome / tsetse fly interface. Research
focus: assessment of the animal reservoir of disease for human sleeping sickness and to
delineate the policy implications for control options.
Dr. Sarah Cleaveland is a Senior Lecturer in Veterinary Epidemiology based at the Royal
(Dick) School of Veterinary Science, UEDIN. Research focus: epidemiology of rabies and
other infectious diseases at the human-wildlife-domestic animal interface in Tanzania.
Contributor to the 2005 WHO expert consultation on rabies.
Dr. Kim Picozzi, Senior Post Doctoral Researcher at the CTVM, UEDIN, Laboratory
Manager. Research focus: Development of new molecular methodologies and diagnostic
techniques to investigate the molecular epidemiology of trypanosomiasis.
Dr. Beatrix von Wissmann, Post Doctoral Researcher at the CTVM, UEDIN. Research
focus: Spatial and molecular epidemiology of zoonotic trypanosomiasis in East Africa.
48
FP7-KBBE-2007-1-3-09
Part B
PARTNER 2: DEPARTMENT OF ANIMAL HEALTH, INSTITUTE
MEDICINE (ITM), ANTWERP, BELGIUM
ICONZ
OF
TROPICAL
The helminthology and protozoology units of the Department of Animal Health have a large
experience in the field of teaching and research on tropical diseases of livestock, particularly
trypanosomiasis and cysticercosis, two important zoonotic diseases which are included in this
project. The staff is involved in the organization of an annual Master course in Tropical
Animal Health for veterinarians and agronomists from developing countries. In the field of
research the Department has ongoing projects in Asia, Latin America and Africa. Many staff
members have a longstanding experience in research projects in collaboration with African
universities and research institutes. Currently, research projects in the field of trypanosomiasis
or cysticercosis on the African continent are going on in Burkina Faso, Cameroon, the D.R.
Congo, The Gambia, Mozambique, Zambia and South Africa. These projects focus on the
epidemiology and control of both parasitic diseases, improved diagnostic tools (e.g. molecular
tools for the detection of resistant trypanosome strains, a monoclonal antibody or nanobody
based antigen detection ELISA for cysticercosis). Currently, a field trial is going on in
Cameroon to assess the efficacy of a vaccine against porcine cysticercosis (in collaboration
with the University of Melbourne).
SCIENTIFIC LEADER
Stanny Geerts, DVM, PhD, Dipl. EVPC, is head of the protozoology unit of ITM, which is a
FAO reference Centre for trypanosomiasis. He has a longstanding experience in the field of
trypanosomiasis and human and porcine cysticercosis.
KEY PERSONNEL
Pierre Dorny, DVM, PhD, Dipl. EVPC, is head of the helminthology unit of ITM, Antwerp
and professor (part-time) in tropical veterinary medicine at the University of Ghent. He is
mainly involved in research on parasitic zoonoses.
Nicolas Praet, DVM, and Nynke Deckers are PhD students in the helminthology unit of
ITM, working on epidemiology and immunodiagnosis of cysticercosis, respectively.
49
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 3: DEPARTMENT OF VETERINARY PATHOBIOLOGY, FACULTY OF LIFE
SCIENCES, UNIVERSITY OF COPENHAGEN (UCPH), DENMARK
The department serves as WHO/FAO Collaborating Centre for Emerging and Other
Parasitic Zoonosis, and senior scientists from two divisions are allocated for the project: M.
V. Johansen (DBL - Centre for Health Research and Development (DBL)), and A. L.
Willingham & S. M. Thamsborg (Danish Centre for Experimental Parasitology (DCEP)). Our
department has extensive experience with work in developing countries (particularly in
Africa) and close links to African research institutions and universities, e.g. Makerere
University, Muhimbili Medical College, Sokoine Agricultural University, University of
Zambia and Eduardo Mondlane University. All scientists have specialist knowledge (>20
years) on aspects of applied and experimental parasitology with a focus on helminths in
livestock, mainly zoonotic parasites. The team has extensive national and international
teaching and research capacity building experience, e.g. DBL has for 10 years performed an
annual course on advanced research methodology for overseas students, and DCEP runs a
M.Sc. programme on Parasitology and is partaking in a Marie Curie training network
focusing on traditional medicine against helminths. In addition the DCEP/DBL team has
facilitated the establishment of the Cysticercosis Working Group in Eastern and Southern
Africa which has been promoting communication, collaboration and coordination of
integrated research and control activities to combat cysticercosis in that region for more than
5 years. Our research covers a wide range from developing of diagnostic assays, assessing
host responses, experimental infections to epidemiological investigations and control
programs in developing countries with extensive international collaboration, e.g. EU-projects.
The team is thus well equipped to carry out the planned investigations and has sufficient
laboratories and human and technical resources. Over the last 15 years, >110 national and
international (>25 African) Ph.D. students have graduated from DCEP/DBL and >300 papers
were published in internationally refereed journals 2003-7. The team has long standing
collaboration with teams 1, 2, 9, 10, 14, 16, 18, 19 and 22.
SCIENTIFIC LEADER
Stig M. Thamsborg (M), DVM, Ph.D., Dipl. EVPC, is professor in veterinary parasitology,
director of DCEP. Co-ordinator EU-project WORMCOPS (2001-4). Expert on applied and
experimental parasitology, alternative control and parasite population dynamics with >80
international papers.
KEY PERSONNEL
Maria Vang Johansen (F), DVM, Ph.D., Dipl. EVPC, senior researcher with >20-years
experience in parasitology and numerous publications (>80), mainly on development and
validation of parasitological methods, host/parasite relationships, epidemiology and control of
zoonotic helminths in livestock and man.
Arve Lee Willingham (M), DVM, Ph.D., associate professor with 20 years experience in
parasitology and numerous publications (>50), mainly on epidemiology, impact and control
of zoonotic helminths of both public health and agricultural importance in developing
countries. Involved in coordination of helminth zoonoses research capacity building and
networking in Africa and Asia for over 10 years.
50
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 4: AGENCE FRANÇAISE DE SÉCURITÉ SANITAIRE DES ALIMENTS
(AFSSA) LABORATORY OF RESEARCH ON RABIES AND WILDLIFE DISEASES
(LERRPAS), FRANCE
AFSSA is a governmental institution created in 1999 from the former CNEVA. The Agency
is jointly answerable to the Ministries of Health, Agriculture and Consumer Affairs and is
tasked to contribute to ensuring food safety, from the production of raw materials through to
distribution to the final consumer. The main objective of the laboratory was historically to
combat rabies. In the 1980's, the activities of the laboratory were enlarged to research on
zoonotic diseases with high impact on human health (mainly Echinococcosis) and the
development of a national database recording epidemiological results on wildlife diseases.
Activities are conducted in Nancy at LERRPAS (Laboratory for Studies and Research on
Rabies and Wild Animal Disease) with a multidisciplinary approach, (epidemiology,
virology, immunology and vaccinology, molecular biology, pathogenesis and animal-animal /
animal-human transmission of viruses, field work).
LERRPAS is the national reference institute mandated by the Ministry of Agriculture since
January 1999 for monitoring the epidemiosurveillance of rabies on domestic and wild
animals. The LERRPAS is also the national reference laboratory for Echinococcus since
2006. The laboratory is a WHO Collaborating Centre for Research and Management in
Zoonoses Control since September 1983. It is an OIE reference laboratory for rabies since
June 1999 and the Community Reference Institute for rabies serology since March 2000. The
laboratory provides scientific and technical expert support at the European level (EU, EDQM)
and to international organisations (OIE, OMS) through assigned activities.
The team has extensive teaching and research capacity for rabies and echinococcosis. The
laboratory has extensive experience in collaborations with countries in Europe, Americas,
Asia and Africa. Our research covers a range from diagnosis, vaccine control, serology
assays, experimental infection and epidemiological investigation and management of controls
programs in domestic animal and wildlife in developing countries. In the last 10 years the
laboratory has published more than 350 scientific papers.
SCIENTIFIC LEADER
Dr Franck Boué, Senior Research, PhD in biology of reproduction, has 15 years of
experience in research in biochemistry and molecular biology. He is head of the unit on
research on rabies and emerging diseases and is implicated in parasitic studies on
Echinococcus with > 30 international papers.
KEY PERSONNEL
Dr Florence Cliquet, Research Director, PhD in immunology has 15 years of experience in
rabies and is Head of the laboratory. She is expert in rabies for OIE and WHO. She is
involved in research rabies on domestic and wildlife animals with > 150 international papers.
Dr Jacques Barrat, DVM, has 26 years of experience in rabies. He is Head, of
Epidemiosurveillance of Diseases in Wildlife and Domestic carnivores Unit, of wildlife
diseases monitoring and of animal experimentation with > 150 international papers. Expert
OIE for Rabies.
51
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 5: DEPARTMENT OF PARASITOLOGY (ISPBL) - UNIVERSITY CLAUDE
BERNARD LYON 1 (UCBL), FRANCE
The Department of Parasitology of the Pharmacy Department (ISPBL) fosters collaboration
between researchers and students from different training backgrounds (veterinarians,
pharmacists) and of different nationalities, working on zoonotic diseases with a special focus
on echinococcosis, for which the service developed internationally recognised expertise
through different contracts, including EU contracts, Franco-Tunisian collaborations as well as
patents in fields of diagnosis, treatment and prevention.
We also participated in the training of researchers (doctors, veterinarians & pharmacists) from
developing countries in the framework of training in tropical medicine and parasitology
organized by UNESCO in Granada (Spain), or Panama. Our department has been working for
many years in Morocco and Tunisia collaborating closely with the IAV and the Veterinary
Faculty of Sidi Tabet on experimental aspects and applied solutions for the diagnosis,
prevention and treatment of the hydatic cyst in sheep and dogs. The laboratory is well
equipped and has access to various transversal services in the University. Our department has
developed several international collaborations and published more than 200 papers in
international or national journals.
The team is well equipped both in experience and personnel to conduct the planned
investigations on the epidemiology of echinococcosis in ruminants and dogs, including
vaccination trials (in collaboration with M. Lightowler), anthelmintic control and community
awareness to verify the effectiveness of the triple bottom line “education – worming –
vaccination” on the hydatid disease in the broader context of the fight against livestock
diseases and the improvement of animal welfare. This approach has the advantage of being
potentially extended to other countries, and it allows us to refine our knowledge of the
behaviour of canine populations for a secondary use of outside contract dog vaccine against
echinococcosis developed by our team
SCIENTIFIC LEADER
Anne-Françoise Petavy – Professor in Parasitology at Université Claude Bernard Lyon 1 –
section pharmaceutical sciences. Head of Laboratory
Doctor in Pharmaceutical sciences: specialist in ParasitologyDoctor in Veterinary sciences. Long experience of Parasitology in developing countries
(Tunisia, Morocco but also Burkina or Ivory coast).
KEY PERSONNEL
Ph. Lawton PhD Pharmaceutical sciences - Specialist in Parasitology and immunological
methods mainly Cestode and Protozoan Apicomplexa
S. Azzouz PhD- Granada University –Scientist specialist in genetic and biochemical methods
Good knowledge of developing countries mainly Morocco where she worked many years and
she also worked in tropical diseases (Chagas disease, leishmaniasis) during her stay in the Lab
of Professor Osuna in Spain
52
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 6: NATIONAL VETERINARY REFERENCE LABORATORY ON
TUBERCULOSIS, FRIEDRICH-LOEFFLER-INSTITUTE (FLI), FEDERAL RESEARCH
INSTITUTE FOR ANIMAL HEALTH, JENA, GERMANY
The Friedrich-Loeffler-Institute is an independent higher federal authority affiliated with the
Federal Ministry for Food, Agriculture and Consumer Protection consisting of eleven subinstitutes. Different national reference laboratories including the National Veterinary
Reference Laboratory on Tuberculosis, which is integrated in the mycobacterial working
group, are located within the FLI and the institute serves as OIE Collaborating Centre. The
NRLs fulfil official tasks including the surveillance and improvement of the diagnostics for
notifiable animal diseases and zoonoses. The scientific leader of the project, Irmgard Moser,
has specialist knowledge (> 20 years) on aspects of different bacterial diseases with focus on
tuberculosis and campylobacteriosis. She has many years of experience in national and
international teaching at the university and training of Ph.D. and Diploma students. The
research of the tuberculosis reference laboratory covers bacterial diagnostics as well as
epidemiological investigations with international collaboration. Experience in assessing host
response exists as well. The FLI panel of experts comprises a wide variety of expertise, both
in the field of laboratory diagnostics as well as in practical field implementation of disease
surveillance and control measures.
SCIENTIFIC LEADER
Irmgard Moser (Dr. med. vet., Ph.D.),
Head of the National Veterinary Reference Laboratory on Tuberculosis
KEY PERSONNEL
Manfred Tanner (Dr. med. vet.),
Working Group International Animal Health (WGIAH) at FLI Riems, expert on zoo and
wildlife diseases (>10 years), spent more than 5 years in African national parks and game
reserves and worked as state veterinarian in South Africa as well as zoo veterinarian in
Germany. Doctoral thesis on the viability of M. bovis in the Kruger National Park.
Wolfgang Böhle (Dr. med vet.),
Head of WGIAH at FLI Riems, worked more than 20 years in Africa and Asia (GTZ, EU and
FAO projects), 2003-2006 Animal Production and Health Officer of FAO for East and
Southern Africa.
D. Höreth-Böntgen (Dr. med. vet.),
WGIAH at FLI Riems, worked more than 15 years in GTZ and FAO projects in East and
Southern Africa, expert on control policies of animal epidemics and vector borne diseases.
53
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 7: LIFE AND HEALTH SCIENCES RESEARCH INSTITUTE (ICVS)
SCHOOL OF HEALTH SCIENCES, UNIVERSITY OF MINHO (UMINHO), BRAGA,
PORTUGAL
At the Microbiology and Infection Research Domain (MIRD) at ICVS research is focused on
host-pathogen interactions in mycobacterial infections (Mycobacterium tuberculosis, M.
bovis, M. bovis BCG, M. avium and M. ulcerans). More specifically on the improvement of
our understanding of the immune response to mycobacterial infections and of the
effectiveness of tuberculosis diagnosis in Portugal (one group members is part of the
Portuguese National Board for Tuberculosis Control). MIRD activities have recently
expanded to the epidemiology of tuberculosis in wildlife in Portugal. Researchers at MIRD
have established collaborations with Mozambique, Democratic Republic of Congo (DRC) and
Benin. In Mozambique the collaboration has been mostly dedicated to training activities in
partnership with the Ministry of Agriculture and the Faculty of Veterinary Medicine. The
collaboration with Benin and DRC has brought samples from patient infected with M.
ulcerans to the ICVS, where ongoing work is aiming at characterizing the physiopathology of
the Buruli Ulcer (BU). Additionally, samples collected from the environment in endemic
areas, as well as insects, are being tested to identify the sources of M. ulcerans.
The ICVS is a research unit within the School of Health Sciences, an institution that is
strongly committed to comply with the most recent international recommendations for
undergraduate medical education. The school developed its own electronic learning
management system (LMS) which is under the responsibility of the Medical Education Unit
(MEU). Manuel João Costa is the Head of the MEU which is also in charge of the monitoring
and development of every aspect of the educational programme.
SCIENTIFIC LEADER
Margarida Correia-Neves, veterinary, PhD, is Assistant professor of Microbiology and
Immunology and principal investigator of tuberculosis projects. As a member of the NGO,
Science for Development, she has promoted training courses on tuberculosis and other animal
diseases in Mozambique (2001, 2002 and 2004) and has established the collaborations with
Mozambique.
KEY PERSONNEL
Jorge Pedrosa, PhD, is Associate Professor of Microbiology and Immunology. He is
principal investigator in various projects on BU, and has established collaborations with
endemic countries, namely DRC (Ministère de la Santé) and Benin (Centre Sanitaire et
Nutritionel Gbemoten, Zagnanado). From 2002 to 2003 was a Member of the Steering
Committee of the “European and Developing countries Clinical Trial Programme for povertyrelated diseases”, as Portuguese representative-Delegate.
Nuno Santos, veterinary, is the head veterinary of the largest Portuguese National Park
(Parque Nacional Peneda Gerês). During is master thesis he has shown, for the first time, the
presence of tuberculosis in the wild life in Portugal (wild board). Nuno Santos will join the
present team as a PhD student.
Manuel João Costa, PhD, is Assistant Professor and the head of the Medical Education Unit,
with long-time expertise in learning/teaching methodologies and evaluation. He is member of
the Editorial board of Educational Journals and is member of the Education Committee of the
International Union of Biochemistry and Molecular Biology.
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FP7-KBBE-2007-1-3-09
PARTNER 8: DEPARTMENT
(UNAV), SPAIN
Part B
OF
MICROBIOLOGY, UNIVERSITY
ICONZ
OF
NAVARRA
The Department is a National Participating Centre of the Mediterranean Zoonoses Control
Programme (MZCP) of the WHO. The Department has experience in cooperating with
scientists in ICPC countries through the organization of international workshops on
brucellosis diagnosis and prophylaxis in cooperation with WHO, FAO, MZCC and the
International Center for Advanced Mediterranean Agronomic Studies (CIHEAM – IAMZ).
Three senior scientists of the Department, Professors I. Moriyón, I. López-Goñi and M. Iriarte
will participate in the project, all of them with long experience in Brucella genetics and
physiology as well as in the diagnosis and immunoprophylaxis of the disease with over 150
publications in internationally refereed journals. In these topics, the team has ongoing
cooperation with laboratories in several EU countries as well as in Central America and
Kazakhstan. Current research is focused on Brucella cell surface virulence factors and the
development of alternative Brucella vaccines, the genetic control of virulence and physiology,
and the development of molecular tools for Brucella identification and typing. The
Department is well equipped to carry out the planned investigations and has sufficient
laboratories and human and technical resources.
SCIENTIFIC LEADER
Ignacio Moriyón, Ph.D., Chairman of the Department; Professor, has participated in several
EU funded project and acted as coordinator of the EU project QLK2-CT-2002-00918-BRUVAC on the genetic design of R Brucella vaccines. Expert in Brucella antigens, serological
diagnosis and brucellosis vaccines, with over 80 papers in internationally refereed journals.
Current member of the International Committee on Systematics of Prokaryotes.
Subcommittee on the taxonomy of Brucella.
KEY PERSONNEL:
Ignacio López-Goñi, Ph.D., Professor, with over 15 years of research experience on Brucella
virulence factors, genetics, and molecular diagnosis and typing, has published over 30 papers
on these topics in internationally refereed journals.
Maite. Iriarte, Ph.D., Professor, with over 15 years of research experience on Yersinia and
Brucella virulence factors and genetics; she has published over 30 papers on these topics in
internationally refereed journals.
Collaborating researcher
José María Blasco Martínez, DVM, PhD, Permanent Researcher at the Health Animal Unit
of CITA (Gobierno de Aragón, Spain) will cooperate with the UNAV team. Expert in
brucellosis diagnosis and vaccination with over 20 years of experience and more than 70
papers on these topics.
55
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 9: KAROLINSKA INSTITUTET (KI) / SWEDISH INSTITUTE
INFECTIOUS DISEASE CONTROL, SWEDEN
FOR
The TB group at the Karolinska Institutet/Swedish Institute for Infectious Disease Control has
several decades of experience in TB research. The group consists of about 15 people, devoted
to research on diagnostics, (molecular) epidemiology and new vaccines. The laboratory is also
the WHO reference laboratory for surveillance of drug resistance in several high TB endemic
countries.
For the purpose of studying the molecular epidemiology and diagnostics of human and bovine
TB in Africa, we are collaborating with four African partners, Makerere University in Uganda
(Dr Moses Joloba), Eduardo Mondlane University in Mozambique (Dr Adelina Machado),
Laboratorio Nacional de Saude Publica in Guinea Bissau (Dr Francisco Dias) and
Stellenbosch University in South Africa (Dr Paul van Helden).
Of particular interest is the development in our institute of a rapid and simple urine test for
diagnosis of TB, which in principle can also be applied to any animal species, as it is an
antigen detection test. The work concerning human TB is supported by the Foundation for
Innovative New Diagnostics (FIND), which is a Bill and Melinda Gates sponsored
Foundation. We are also working on the development of a new carbohydrate microchip
serological screening diagnostic test and a new tuberculosis vaccine (funded by AERAS,
another Bill and Melinda Gates sponsored Foundation). Our team has collaboration with
teams 7 and 15 (bovine TB).
SCIENTIFIC LEADER
Gunilla Källenius, MD, PhD, professor in Bacteriology at Karolinska Institutet and
Smittskyddsinstitutet (SMI): Swedish Institute for Infectious Disease Control. Co-ordinator
EU project THIDOC (2006-2009). As head of the Swedish TB reference laboratory she has
for more than 20 years been working in the field of diagnosis, epidemiology and pathogenesis
of TB, with a special interest in bovine TB, with >130 internationally peer reviewed
publications.
KEY PERSONNEL
Tuija Koivula (PhD) is working on molecular epidemiology and evolution of M. tuberculosis
in Africa.
Stefan B. Svenson (Dr Med. Sci, PhD) is professor at the Swedish University of Agricultural
Sciences, in Uppsala and consultant at SMI in infectious disease control. He has a broad
background including molecular biology, organic chemistry (in particular bacterial
carbohydrates), biochemistry and protein/peptide chemistry, with close to 200 articles
published in peer reviewed international scientific journals. He is also inventor/co-inventor of
more than 20 patents in the area of diagnostics, biotechnology and vaccines, several of which
are applicable for the current proposal.
Beston Hamasur (PhD) has been working the last 15 years on TB, mainly on rapid diagnosis
of TB, for which he is instrumental. He has been the laboratory bench leader for two EU
supported TB diagnostic projects and has an outstanding expert knowledge in this field.
Andrzej Pawlowski (M.D. PhD) has been working for the last 15 years mainly on the
development of new TB vaccines. He also has a vast experience of TB diagnostics, chemistry
and immunology.
56
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 10: SWISS TROPICAL INSTITUTE, BASEL (STI), SWITZERLAND
The Swiss Tropical Institute (STI) is associated to the University of Basel, but has also
mandate to contribute to the health of populations at an international level. The human and
animal health (HAH) research group is a unit within the Department of Public Health and
Epidemiology and coordinates the work on the epidemiology and economics of brucellosis
control. This unit collaborated closely with the Swiss Centre for International Health, which is
the department of health development at STI, on brucellosis control in Mongolia, mandated
by WHO and FAO. Jakob Zinsstag is a veterinary epidemiologist leading the HAH group
with a strong focus of zoonoses control in developing countries from a “one health”
perspective, integrating as far as possible animal and public health. He developed the animalhuman brucellosis transmission model for Mongolia and together with Felix ROTH and
Mongolian partners performed the economic analysis of brucellosis control in Mongolia. His
main interest is the control of zoonoses in developing countries with work on rabies control in
developing countries, brucellosis and Q-fever and the molecular epidemiology of bovine
tuberculosis. He currently builds up a network on bovine tuberculosis in Africa, funded by the
Wellcome Trust.
SCIENTIFIC LEADER
Prof. Marcel Tanner (M), professor of epidemiology and public health, University of Basel.
Expert in Control of Malaria and Schistosomiasis, International health and health systems
with >100 peer reviewed papers
KEY PERSONNEL
Jakob Zinsstag, DVM, Ph.D., Dipl. ECVPH, senior researcher with >20-years experience in
international animal health, parasitology and zoonoses control, over eight years field
experience in West-Africa and numerous publications (>80), mainly on health of nomadic
people and zoonoses control.
Esther Schelling, DVM, Ph.D., senior researcher with 10 year experience in international
animal health, health of nomadic people and zoonoses research.
57
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 11: NATIONAL CENTRE FOR ZOONOSIS RESEARCH (NCZR),
UNIVERSITY OF LIVERPOOL (ULIV), UK
The NCZR specialises in a range of activities of which the creation and maintenance of
genomic and epidemiological databases, spatial-temporal analysis and modelling, the
provision of evidence-based information and the identification of gaps in evidence and
knowledge are relevant to this proposal. The Centre has an array of projects focussing on
zoonotic pathogen transmission and evolution using the recent developments in modelling
and network-theory to describe the complex interactions that drive the dissemination of
pathogens through populations. Projects have included funding from EU, UK and Wellcome
Trust.
Our IT expertise includes developing large and complex dynamic websites and databases
including the analysis of the latter. We run a dedicated server that hosts a powerful database
management system (SQL Server 2005), a content management system (Confluence) and a
web server (IIS) apart from other things. The server is administrated by the University's
computer service department to ensure security, regular backups and performance. Dynamic
web-sites are implemented using mainly ASP.NET 2.0 and JavaScript. The data analysis is
performed using statistical programs such as R, SAS, Pajek and MATLAB. Data are
generated using queries (T-SQL, stored procedures) that are executed in our database
management system. The team is well equipped to carry out the planned investigations and
has sufficient technical resources.
SCIENTIFIC LEADER
Jim M. Scudamore (M) CB. BVSc., BSc. (Hons), MRCVS., Dipl ECVPH. Professor of
livestock and veterinary public health. Former UK Chief Veterinary Officer and Director
General for Animal Health and Welfare. Consultant to the European Technology Platform for
Global Animal Health and involved in the detailed preparation and production of the strategic
research agenda and action plan for the platform. Worked on surveillance and control of
animal diseases in particular zoonoses and has interests in developing research which will
deliver new and improved tools to control priority animal diseases and zoonoses. Consultant
to the DISCONTOOL FP7 programme to develop prioritisation and gap analysis for the
priority diseases
KEY PERSONNEL
Christian Setzkorn BSc (computer science), MSc (computer science), PhD (computer
science/data
analysis) has 5 years experiences in developing large and complex database and dynamic web
sites for international collaborations. He is also experienced in analyzing and modelling large
databases. Major achievements include the implementation, publication and application of
several novel approaches to analyse data.
Caroline Harcourt, BSc MSc PhD (Zoology, Primatology) is currently working as the
research and information officer for the UK North West Zoonoses Group and the NCZR. She
has been involved with work on zoonotic diseases for the last five years. This involves
frequent updating of websites with the addition of new information. She arranges numerous
meetings and several workshops and conferences each year, produces a weekly report on
emerging diseases, which is widely circulated in the UK. She contributes to a major project
on Emerging Infectious Diseases, being funded by Defra, in particular collecting and entering
data. She has a wide network of contacts, both nationally and internationally in relation to
zoonotic diseases.
58
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 12: CENTRAL VETERINARY LABORATORY (LCV), BAMAKO, MALI
LABORATOIRE CENTRAL VÉTÉRINAIRE
LCV is a national laboratory that has an established track record of performing diagnostic and
research activities of animal diseases and production of animal vaccines in West Africa. It
was established in 1979 with the primary assignments: 1) to contribute to the prevention and
eradication of animal diseases through diagnostic and research activities, 2) screening for
zoonoses and quality control of food, water and beverages, 3) production of vaccines and
sanitary protection of livestock against infectious diseases and 4) technical training and
continuous education of technicians in the field of laboratory techniques. The Department of
Animal Vaccine Production, the Department of Diagnostic and Research and the Department
of Administrative and Engineering services constitute the LCV. At LCV, research activities
are concentrated on infectious and parasitic diseases in particular 1) the prevalence of animal
disease of economic importance in Mali, 2) development of simple and sensitive diagnostic
methods for field conditions, 3) development of new effective vaccines against these diseases.
The Mycoplasma laboratory, is today considered as one of the leading CBPP diagnostic and
research laboratory in West Africa. Interdisciplinary and collaborative linkages are
established with the world’s leading scientists in their respective field. Frequently, the CVL
scientists are called upon to collaborate with research teams not only in the developed
countries (Europe, USA), but also in developing countries. Therefore, through the continuing
partnership with international agencies around the world including USAID, AIEA, FAO and
international research centers such as CIRAD-EMVT (France), ILRI (Nairobi, Kenya),
CIRDES (Bobo, Burkina Faso) and many others, the CVL has became one of the leading
Institute in the diagnosis and research in animal diseases, and production of animal vaccines
in west Africa. Locally, the CVL is in contact with the Institute of Agronomic Research, the
Animal Health Department, the Medical Research School & others institutions.
SCIENTIFIC LEADER
Saidou Tembely, Ing. Sci. Appl., MS, PhD, Director of Research (CAMES-2007) and
Director General of the LCV (2003-present). Prior to this position Dr Tembely has served as
an Associate Scientist at the International Livestock Research Institute (ILRI) and Head of the
ILRI Parasitology Laboratory in Addis Ababa (1992 to 1997) working on genetic resistance
of small ruminants to endoparasites, parasite population dynamics in ruminants and control
strategies of parasites in livestock with > 20 international publications in refereed journals.
KEY PERSONNEL
Abdel Kader Traore, Professor of Internal Medicine and Medical Scientific Communication
at the School of Medicine. Participant of the WHO training of coordinators for the national
control programme for HAT. Key investigator on studies of brucellosis, rift valley fever;
member of the international network of rabies.
M. Niang, MSc, PhD, senior scientist with >20 years experience in the field of laboratory
and field work including microbiology, immunology, epidemiology and bacterial zoonotic
diseases, participant in several INCO collaborative projects.
A. Fane, Ing. Sci. Appl., DEA, MSc senior scientist with >20 years experience in laboratory
and field work including microbiology, immunology & bacterial zoonotic diseases.
Participant of "Lait Sain pour le Sahel "collaborative research project.
Abdallah Traoré, MSc, research associate, >20 years experience in laboratory work.
Research focus : zoonoses (brucellosis, rift valley fever), working on the development of a
marker vaccine and ELISA for the control of PPP as part of a EU funded project.
59
FP7-KBBE-2007-1-3-09
Part B
PARTNER 13: INSTITUT AGRONOMIQUE
RABAT, MOROCCO
ICONZ
ET
VETERINAIRE HASSAN II (IAVH2),
The IAV was established by a royal decree in 1968 as a university-level Agronomy and
Veterinary Medicine training and research institution. With 350 faculty members, 2,300
students and two campuses (Rabat and Agadir), the IAV has 6 sections: Agronomy,
Veterinary Medicine, Topography, Agricultural & Food technology, Horticulture and Rural
equipment. The Veterinary Medicine Section (VMS) is composed of 4 specific departments:
Biologic, Pharmacy & Veterinary Science, Pathology and Veterinary Public Health
(DPVPH), Medicine and Surgery, University Veterinary Hospital Centre. Two departments
(Animal sciences, Rural economics & Human Sciences) are shared with the other sections.
VMS field activities include all animal health, zoonoses and food hygiene problems related to
the specific ecological and socio-economic conditions of Morocco.
The DPVPH is an OIE Reference Laboratory for Echinococcosis/Hydatidosis. Two
DPVPH Laboratories are partner in ICONZ. Laboratory of Parasitology (units:
Epidemiology and Ecology, Pathophysiology, Immunology and Molecular Biology) is
actively involved in training, research and consultancy services for Veterinary Parasitology
and Parasitic Zoonoses (with focus on Leishmaniasis and Echinococcosis /Hydatidosis).
Laboratory Bacteriology & Virology (units: Bacteriology, Serology and Virology) is
actively involved training, research and consultancy services for Veterinary infectious
diseases with special reference to tuberculosis, respiratory diseases, abortive diseases
(including brucellosis), arboviroses, West Nile, sheep pox, rabies, and bluetongue. The
faculty members participating in this project have strong linkages with the Ministry of
Agriculture and the Ministry of Health providing consultancy in Parasitology and Infectious
Diseases.
SCIENTIFIC LEADER
Allal Dakkak DVM BSc, PhD Professor of Parasitology and Parasitic Zoonoses at the
PVPH, IAVH2. Invited lecturer of the Ecole Nationale Vétérinaire de Toulouse, France
(major parasitic diseases in livestock and zoonoses in the Mediterranean), leading author of
>70 scientific articles, contributor in 3 books on Parasitology and Parasitic Diseases, principal
investigator of 12 research projects on animal parasitic diseases and on parasitic zoonosis
(mainly Leishmaniasis & Echinococcosis) and he is an OIE expert for echinococcosis.
KEY PERSONNEL
Mrs Ouafaa Fassi Fihri DVM MSc PhD. Professor of Infectious Diseases at IAVH2, FAO
consultant for rabies, West Nile and Bluetongue. Research interests: epidemiology & control
of veterinary infectious diseases.
Jaouad Berrada DVM PhD PhD Professor of Infectious Diseases, FAO consultant for
tuberculosis. Research interests: epidemiology & control of veterinary infectious diseases
(focus: tuberculosis, paratuberculosis & brucellosis).
Mohamed Bouslikhane DVM Professor of Infectious Diseases, epidemiology & control of
veterinary infectious diseases (focus: tuberculosis, brucellosis, theileriosis and
echinococcosis/hydatidosis)
Mrs Touriya Atarhouch BSc PhD associate scientist in DPVPH, research interests:
immunology, molecular biology and serology (focus: diagnostic, typing and finger printing
molecular tools, population genetics).
60
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 14: VETERINARY FACULTY, EDUARDO MONDLANE UNIVERSITY
(UEM), MAPUTO, MOZAMBIQUE
The Veterinary Faculty is one of the Faculties from Eduardo Mondlane University, Maputo,
Mozambique. Staff members involved on this project are from the area of microbiology,
parasitology, pathology, food hygiene and the Centre of Biotechnology recently established in
coordination with the faculties of Medicine, Biology and Agronomy and also Masters
students. In Mozambique a number of zoonotic diseases such as tuberculosis, rabies,
brucellosis, cysticercosis trypanosomiasis, toxoplasmosis and Rift Valley fever are frequently
reported and considered extremely important, making the country a suitable location for
research in this area.
The Veterinary Faculty of the Eduardo Mondlane University has been involved in research
and other activities in the area of zoonoses in collaboration with the Medical Faculty and
animal and human health authorities. Presently, the faculty has established the sero-diagnosis
of cysticercosis (Ab-ELISA) that is being used in the study of cases of human epilepsy. Serosurveys for toxoplasmosis have been conducted in sheep, goats, pigs and dogs in several
regions of Mozambique. A recombinant protein was recently cloned and purified with the
ultimate goal of developing a diagnostic assay for Rift Valley fever. Regarding tuberculosis,
the role of apoptosis in bovine, the assessment of γ-interferon assay for diagnosis and the
molecular typing of Mycobacterium strains are the main research lines.
The Faculty intends to be a national reference institution in Zoonosis Research. To reach this
aim the faculty has applied and received a grant SAREC for a large collaborative programme
on zoonosis research with 3 institutions from Mozambique and 3 from Sweden, coordinated
by the Karolinska Institute. This together with the participation in the Cysticercosis working
group of Eastern and Southern Africa are examples of the faculty experience in collaborative
research. The Faculty is in process of establishing a Masters course with 3 specialization
areas: Animal Health, Laboratory diagnosis and Veterinary Public Health. The start of this
course in 2009 will increase the number of junior researchers available to conduct the
activities of the proposed research application.
SCIENTIFIC LEADER
Sonia M.S. Afonso (F), DVM, MSc is lecturer in veterinary parasitology. Working with
helminthes and member of Cysticercosis Working Group of Eastern and Southern and Africa
(CWGESA)
KEY PERSONNEL
A. Machado (F), DVM, MSc, senior researcher with 15 years of experience in Hygiene and
Public Health.
Luis Neves (M), DVM, PhD., associate professor with 20 years of experience in parasitology
and molecular biology. Actually is head of Preclinical Department at Veterinary Faculty and
Dean of Eduardo Mondlane Biotechnology Centre
J.M. Fafetine (M), DVM, MSc, senior researcher with more than 15 years of experience in
Microbiology.
61
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 15: BRUCELLOSIS RESEARCH LABORATORY, NATIONAL VETERINARY
RESEARCH INSTITUTE (NVRI VOM), VOM, NIGERIA
The National Veterinary Research Institute, Vom is involved in Vaccine production, Research
and Diagnosis of animal diseases. In 2007, it became recognized by FAO and OIE Regional
Center for animal Disease and OIE reference lab for Avian influenza. The Bacterial Research
Department conduct research into the epidemiology, prevention and develop methods for the
treatment and control of major endemic bacterial diseases of livestock and poultry in Nigeria,
identified as priority diseases of economic importance by the Institute. It also conducts
research towards improving upon the existing bacterial vaccines as well as development of
reagents and media for research and diagnosis. Additionally, there is provision of Surveillance
services to livestock farmers supported by applied and fundamental research studies. The
Department maintains qualified staff and basic facilities for detecting and investigating
endemic bacterial diseases. There are 5 bacterial diseases of particular importance;
mycoplasmosis, pasteurellosis, brucellosis, infectious coryza and dermatophilosis. In addition,
the Department is involved in collaboration on specific projects supported by the International
Atomic Energy Agency (IAEA) and the OAU-IBAR.
SCIENTIFIC LEADER
Reuben A. Ocholi, (M), DVM, M.Sc, Ph.D., Is a research officer with particular interest in
the epidemiology, and infection and immunity in animal brucellosis. He is the Assistant
Director (Quality Control) in the Institute.
KEY PERSONNEL
W. J. Bertu, (M) DVM, a researcher in epidemiology of animal brucellosis especially in
sheep and goats. Currently rounding up his MSc studies on brucellosis
A. M Gusi, (M) DVM, A researcher with interest on brucellosis of animal especially in
camels and dogs.
S. S. Ngulukun, (M) DVM, MSc, Veterinary Research Officer II
E. Mwankon, (F) MLA, BMLS, Medical Lab Scientist
M. Hassan, (M) MLT, Medical Lab Technician
62
FP7-KBBE-2007-1-3-09
Part B
PARTNER 16: MAKERERE UNIVERSITY FACULTY
(MAK), UGANDA
ICONZ
OF
VETERINARY MEDICINE
Makerere University has been a leading African centre of Higher learning since 1922, and is
rapidly becoming a strategic regional hub to address infectious diseases and Global zoonotic
health challenges.The MAK Veterinary Faculty (FVM) runs research and training
programms in molecular biology & biotechnology, wildlife-, tourism- and ecosystem-health,
alternative medicine, integrated animal resources development, biosecurity & food safety,
diagnostics, systems research, socioeconomics and indigenous knowledge systems. Makerere
has reasonably advanced molecular biology and other diagnostic laboratories, and animal
containment facilities. FVM graduates 50 MSc & PhDs annually and is a pillar in the National
Animal Disease Diagnosis and Control System. Our Faculty’s extensive experience with work
in the Sub-Saharan Africa tropical ecosystems and close links to regional and European
research institutions and universities, e.g. Edinburgh University, Faculty of Life Sciences University of Copenhagen, Free University of Berlin, University of Bergen, Norway,
Karolinska Institute, Sweden and Swiss Tropical Institute, Berne, will greatly benefit the
project. Staff have national and international teaching and research exposure hosting summer
school activities with several European and American universities including Edinburgh, North
Dakota State, California Davis, Manitoba, Saskatoon. MAK scientists act as visiting
professors, scientists and examiners in overseas Universities and have research grants from
the EU, Rockefeller, Carnegie, Wellcome Trust, WHO, FAO, IFS, NUFU and ASERECA.
Makerere has facilitated zoonotic research networks in TB, trypanosomiasis and
Cysticercosis. The faculty is the chair of the international network on animal and biomedical
sciences for Africa, and is partner for the Edinburgh e – DL Masters in International Animal
Health. Collaborative research covers a wide range from epidemio-surveillance, developing of
diagnostic assays, assessing host responses, experimental infections to epidemiological
investigations and control, socio-economic and gender studies, alternative medicine,
community development and supply chain study programs. The University has a longstanding
collaboration with The University of Edinburgh and is a partner in Public Private Partnership
to Stamp Out Sleeping Sickness (stampoutsleepingsickness.org). MAK has long standing
collaboration with ICONZ partners 1, 2, 3, 9, 10, 14, 18, 19 & 22.
SCIENTIFIC LEADER
John David Kabasa (M), BVM, MSc, Ph.D., Cert Res Mgt., associate professor, research
and facilitator in animal health and production, systems science and community development
studies. He is Chair of the Faculty Research & Higher Degrees Board, Dean of Faculty and
Chair of International Network on Animal and Biomedical Sciences for Africa. Has >35
international papers.
KEY PERSONNEL:
Charles Waiswa (M), BVM, MSc., Ph.D., Senior lecturer and Head of Department of
Veterinary Medicine with >15-years experience in parasitology and several publications
(>20), mainly on trypanosomiasis research, development and validation of parasitological
methods, host/parasite relationships.
Christine Amongi BSc. MSc. Junior Lecturer with >2years experience of molecular
diagnosis of the animal reservoir of zoonotic trypanosomiasis
63
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 17: SOUTH AFRICAN CENTRE FOR EPIDEMIOLOGICAL MODELLING
AND ANALYSIS, FACULTY OF SCIENCE, STELLENBOSCH UNIVERSITY (SU),
SOUTH AFRICA
SACEMA is a national Centre of Excellence established by the South African Department of
Science and Technology, mandated to research the modelling of disease transmission and
progression, focusing on southern Africa’s major health challenges. The purpose of this
modelling is to provide policy makers with a sound scientific basis for policy decisions.
SACEMA works with a network of partner universities and organisations around the country,
including in neighbouring countries (Botswana and Zimbabwe) to pursue research in the areas
of malaria, trypanosomiasis, TB and HIV. SACEMA also has an agreement in place with the
Onderstepoort Veterinarian Institute in South Africa to pursue tsetse and malaria-related
research.
Relevant research projects include assessing the impact of synthetic tsetse repellents on
trypanosomiasis, analyses of mosquito behaviour, modelling the bait control of tsetse flies,
modelling the role of immunity in the spread of malaria, and modelling the population
dynamics of tsetse flies.
SACEMA personnel will also be co-chairing the International Congress of Entomology to be
held in Durban, South Africa, in July 2008.
SCIENTIFIC LEADER
Prof John W. Hargrove holds a chair in the Department of Mathematical Sciences at the
University of Stellenbosch. He is an expert in the field of tsetse fly biology and control,
applying mathematical analytical and modelling techniques in the field of physiology,
behaviour and population dynamics. He is also involved in the analysis and modelling of
HIV/AIDS data, particularly developing mathematical adjustments of use in estimating HIV
incidence from cross-sectional surveys.
KEY PERSONNEL
Prof Glynn Vale is a visiting research fellow at SACEMA and is also an expert in the vectors
of trypanosomiasis and malaria.
Dr Simon Childs is a postdoctoral fellow at SACEMA, currently working on a general model
for the population dynamics of the tryanosomiases and their vectors, Glossina spp.
Ms Claire Geoghegan is a PhD student working in KwaZulu-Natal, South Africa, on Bovine
TB.
Margaret Ward is responsible for project co-ordination and management of SACEMA
research activities.
64
FP7-KBBE-2007-1-3-09
Part B
ICONZ
PARTNER 18: DEPARTMENT OF VETERINARY MEDICINE AND PUBLIC HEALTH,
FACULTY OF VETERINARY MEDICINE, SOKOINE UNIVERSITY OF AGRICULTURE,
MOROGORO, TANZANIA
The Department of Veterinary medicine and Public Health at Sokoine university of
Agriculture, has a section responsible with teaching and research in the field of public health,
which includes zoonoses. This section has four members of staff with a support of four
laboratory technicians and two field staff.
The section has been involved in a number of research projects regarding zoonotic diseases.
However, the major strength is on Bovine tuberculosis, brucellosis, Cysticercosis, Rabies, and
Campylobacteriosis. The Department has a long standing collaboration with the Centre for
Tropical Veterinary Medicine, University of Edinburgh in research on Bovine tuberculosis,
Brucellosis and Rabies. While work in porcine cysticercosis has jointly been done with Dept.
of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen. Our
department is involved in creation of subject specialist networks in field of zoonoses. We are
engaged in Bovine tuberculosis network for Africa (Prof. Rudovick Kazwala), and in the
Cysticercosis Working Group in Eastern and Southern Africa (Dr. Helena Ngowi) which has
been promoting communication, collaboration and coordination of integrated research and
control activities to combat cysticercosis in that region. Apart from the subject specialist
groups, the department is hosting a section on zoonosis in the Norwegian Government funded
NUFU Collaborative research in environmental toxicology and zoonotic diseases in the
Human – Domestic animal – Wildlife interface areas of Eastern and Southern Africa - A
South-North Veterinary Network. Within this network staff in our department are providing
supervisory and mentoring to young scientists pursing PhD. Over the last 10 year our
department has produced over 5 PhD and 14 Masters students working in the field of
zoonoses and realated fields. There are over 50 peer-reviewed publications among the
researchers in the Section of Veterinary Public Health in the department.
SCIENTIFIC LEADER
Prof. Rudovic R. Kazwala, BVSc, MVM, PhD is Professor in Veterinary Public Health.
Coordinator of Bovine Tuberculosis Network for Africa and Coordinator for Zoonoses
section of NUFU Collaborative research in environmental toxicology and zoonotic diseases in
the Human – Domestic animal – Wildlife interface areas of Eastern and Southern Africa - A
South-North Veterinary Network. Expert on molecular epidemiology of bovine tuberculosis
with > 50 international publications.
KEY PERSONNEL
Dr. Helena Ngowi, BVM, MVM, PhD is a lecturer in Veterinary Public Health, Secretary of
the Cysticercosis Working Group in Eastern and Southern Africa, with about 10-years
experience in working with various rural communities in research and control of zoonotic
diseases, and with more than 10 peer-reviewed publications mainly on the epidemiology and
control of important zoonoses. She is experienced with the development and application of
various health extension materials including pamphlets, radio and video programmes for
control of public-health problems.
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PARTNER 19: DEPARTMENT OF PARACLINICAL STUDIES, SCHOOL
VETERINARY MEDICINE, UNIVERSITY OF ZAMBIA, LUSAKA (UNZA), ZAMBIA
OF
The University of Zambia was established in 1966 and the School of Veterinary Medicine
was established in 1982. The School of Veterinary Medicine has excellent research facilities
and laboratories including an infectious disease unit as well as an established postgraduate
programme and capacity to offer and supervise postgraduate studies leading to MSc. and
PhD. The School has four (4) departments: Biomedical, Paraclinical, Disease Control and
Clinical studies. The Department of Paraclinical Studies is responsible for teaching and
research in the field of Parasitology (among other courses) with emphasis on parasitic
zoonotic diseases. Since 2002, the Department has been conducting studies on
immunodiagnosis of Taenia solium cysticercosis in both humans and pigs. The laboratory has
been designated a regional immunodiagnostic laboratory for Taenia solium by the
Cysticercosis Working Group in Eastern and Southern African (CWGESA). As a regional
laboratory, it has analysed over 7,000 human and pig samples from the CWGESA member
countries. More recently studies on immuno-pathological responses to T. solium in infected
pigs including post-treatment with oxfendazole have been conducted in collaboration with the
University of Copenhagen. Pig confinement and experimental facilities have been
incorporated at the school to enable these studies. The section of Parasitogy has four members
of staff with support of two laboratory technicians. The Section of Parasitology has in recent
past also been actively involved in mapping Lymphatic Filariasis, schistosomiasis and soiltransmitted helminthiasis (STH). The Department serves as a FAO Reference Laboratory on
Epizootic Ulcerative Syndrome (EUS) a fungal disease afflicting fish in the Southern Africa
Development Coordination Conference (SADCC) region. The School itself serves as a FAO
Reference Laboratory on Avian Influenza in the SADCC region.
SCIENTIFIC LEADER
Prof. Isaac K. Phiri, (PhD) is Professor of Parasite Immunology and Clinical Medicine. Prof
Phiri has been coordinator of Danish- and Belgian-funded Research Capacity Building
parasitology projects and has been coordinating research on cysticercosis in Zambia. He has
also been serving as head of the CWGESA regional reference laboratory for
immunodiagnosis of Taenia solium infections. He has authored over 30 peer reviewed
publications. Prof Phiri also serves as Permanent Secretary of the Ministry of Agriculture and
Cooperatives.
KEY PERSONNEL
Chummy S. Sikasunge, BVM, MVM, PhD student is a lecturer in Veterinary Parasitology
(Helminthology). He has 5 years of experience in the immunodiagnosis of T. solium
infections. Currently is working on the immuno-pathological responses to T. solium infected
in pigs including post-treatment with oxfendazole.
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PARTNER 20: AGRICULTURE
(AVIA-GIS), BELGIUM
Part B
AND
VETERINARY INFORMATION
ICONZ
AND
ANALYSIS
Avia-GIS is a Belgian SME founded in 2001 that specializes in the collection, processing and
analysis of spatial information, and the development of space-time information systems
(STIS) with particular reference to animal health and production, agriculture, public health
and health-environment (focus: vector-borne diseases, zoonoses and emerging diseases). The
company specialises in the application of state of the art techniques that broaden the scope of
conventional analyses and decision-making through the inclusion of geographical information
systems (GIS), satellite imagery methodologies, data warehousing and custom software
development. It has recently broadened its scope to include the socio-economic dimensions of
this work (focus: livestock, animal health and human health economics).
In ICONZ Avia-GIS will be responsible, firstly, for spatial data management, statistical
spatial models and spatial information systems, in particular for mapping disease risk under
WP3. Secondly it will lead WP9, providing over-arching socio-economic support to other
WPs and analyzing institutional issues and cost-sharing with a view to enhancing
medical/veterinary collaboration for the control of NZs.
Avia-GIS has initiated and/or is partner in several research projects involving spatial
modelling of insect vectors of disease (Culicoides, Tsetse, Ticks, Mosquitoes), parasites
(Trypanosoma sp., Fasciola, Ostertagia sp.), and is currently developing a spatial veterinary
disease management information system and linked distance learning course (VetGeoTools).
Its involvement in economics began with a pioneering project funded by FAO and DFID
which mapped the potential economic benefits from controlling trypanosomiasis in West
Africa (MAPBEN). This work is now being extended to East Africa with funding from
FAO’s Pro-poor Livestock Policy Initiative. Current projects include “Emerging diseases in a
changing European environment” (EDEN) 2004-2009, funded by the European Commission,
FP6 and, with funding from Belspo from 2007-2010: “Remote Sensing tools to study the
EPIdemiology and Space/TIme dynamicS of diseases” (Epi-STIS) and “Mosquito vectors of
disease: spatial biodiversity, drivers of change, and risk” (MODIRISK) – see www.aviagis.com for further details.
SCIENTIFIC LEADER
Guy Hendrickx, DVM, PhD, founder and managing director of AVIA-GIS is a spatial
epidemiologist specialized in GIS and spatial information systems, with particular application
to integrated vector-borne disease control, risk mapping and livestock geography. He has
over 20 years professional experience in Europe and Overseas, including long term postings
in Rwanda, Tanzania, Togo and Burkina Faso.
KEY PERSONNEL
Alexandra Shaw, BA, MA, PhD is an economist, with over 30 years experience of analyzing
the economics of health programmes in both the medical and veterinary sectors, working in
over 20 African countries for a wide range of bilateral and multilateral development agencies.
Member of the Programme Against African Trypanosomiasis’s Programme Advisory Group
and has served on WHO’s working groups on the economics of Human African
Trypanosomiasis and Rabies. She will be leading the work in WP9.
Further support will be provided by Els Ducheyne, MSc, PhD and Els Goossens, MSc, bioengineers specialized in GIS and Bart De Groot, BSc, an ICT specialist.
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PARTNER 21: LAB901, EDINBURGH, UK
Lab901 Ltd. is an emerging SME in the bio-analysis field. It is a developer of innovative
automation systems for the life sciences, with a number of products on the market and under
development. Lab901 currently has 45 staff covering a highly multi-disciplinary range of
activity which includes molecular biology, chemistry, laboratory automation, electronics,
mechanics, optics, control and analysis software. The company has its own laboratory and
instrument workshop facilities to support development work. It also produces its proprietary
ScreenTape® devices within its own in-house clean room facility. Most recently, Lab901 has
been working with several companies in the area of PCR diagnostics.
SCIENTIFIC LEADER
Richard Rowling is the Sales and Marketing Director of Lab901 and joined in 2007 to begin
commercial operations. Richard has over 19 years of experience in life science sales,
marketing and general management roles with R&D Systems, Novex, PAGEgel and
Invitrogen. He will undertake the nominated representative role on ICONZ and he will be
assisted by Jonathan Salmon and Donna McDade
KEY PERSONNEL
Dr Donna McDade, has been the Applications Scientist for Lab901 since 2006. She has a
PhD in molecular neurobiology and is involved with applications, product management &
product development for the DNA research and diagnostic markets.
Dr Jonathan Salmon is a Senior Project Manager within Lab901 as well as being Team
Leader for all software development activity. He is a graduate in Physics from Imperial
College, London then within The University of Edinburgh he acquired an MSc then PhD in
topics relating to artificial intelligence followed by several years at the university in research
and teaching roles. Since then, he has held senior positions in three early stage technology
development companies prior to joining Lab901 in 2005.
Stuart Polwart is Co-founder and Technical Director of Lab901 and he has played a major
role in driving product architecture and in recruiting a world class development team. A
graduate in Mechanical Engineering from the University of Glasgow, he has over 30 years of
industrial experience in product development including the management of teams producing
military thermal imaging equipment, high speed banking equipment (Unisys) and the high
volume automated manufacture of cellular phones (Motorola). He also has two previous
successful start ups, the most recent developing membrane keypads for cell phones which was
the catalyst for one of the core technologies behind ScreenTape.
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PARTNER 22: INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE (ILRI),
KENYA
The International Livestock Research Institute (ILRI) is a non-profit and non-governmental,
international organization with headquarters in Nairobi, Kenya. ILRI works at the crossroads
of livestock and poverty, bringing high-quality science and capacity - building to bear on
poverty reduction and sustainable development. All ILRI work is conducted in extensive and
strategic partnerships that facilitate and add value to the contribution of many other players in
livestock research for development work. A major focus of ILRI’s work is to contribute to
poverty alleviation by enhancing the health and productivity of livestock and livestock
products by developing/improving and adopting appropriate biotechnological tools for disease
control. Activities include developing and improving vaccines and diagnostic tools for
priority livestock diseases, and designing and evaluating improved strategies for their control,
including their vectors and emerging and re-emerging zoonotic diseases. ILRI has expertise
and research capacity in immunology, vaccinology, diagnostics, bioinformatics,
genetics/genomics, vector biology, epidemiology, and economics. With good laboratory
facilities and longstanding collaboration with the majority of ICONZ partners, African
veterinary authorities and a long list of other European and African Universities, ILRI is
placed well to facilitate networking and collaborations between important institutes active in
the control of zoonotic diseases.
Scientific Leader
John J. McDermott (M) DVM, MPVM, PhD is the Deputy Director General – Research of
ILRI. He is a veterinarian and epidemiologist with over 30 years of experience, almost all in
research on infectious diseases in developing countries. He has authoured or co-authoured
over 200 publications including over 80 papers in international journals and has supervised
over 20 PhD students. He is also Professor or Epidemiology (on leave of absence) at the
Department of Population Medicine, University of Guelph, Canada.
Key Personnel
Phil Toye (M) BVM PhD is Leader of the Animal Health Research group (vaccines and
diagnostics) in the Biotechnology Theme at the ILRI. He has held postdoctoral appointments
to the Harvard Medical School and ILRAD, followed by a core scientist position at ILRAD.
His research interests have focussed on the molecular immunology of parasitic infections.
Up until December 2006, he was Research Manager at Agen Biomedical Limited, a
biotechnological company in Brisbane, Australia, which specializes in in vitro diagnostic
assays. The responsibilities of this position included managing the company’s Research
activities, the Intellectual Property portfolio and the collaborations with external academic
and corporate partners.
Jeff Mariner (M) DVM PhD is a veterinary epidemiologist with over 15 years experience in
Africa and Asia. He is the ILRI Team Leader for Animal Health and International Trade. Jeff
is specialized in disease modelling and participatory approaches to epidemiology.
Tom Randolph (M) PhD is an Agricultural Economist and Operating Project Leader in the
Market Opportunities Research Theme. His areas of interest include policy analysis, animal
health economics, and evaluation of human health impacts of livestock keeping.
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B2.3. Consortium as a whole
The ICONZ Project will be conducted by an international consortium comprising eleven
participants in EU and associated countries; eight ICPC participants, two SMEs and one
international organisation. Participating beneficiary institutes in EU and associated countries
represent a network of existing institutional linkages. ICPC beneficiaries were selected on the
basis that each ICPC institute has linkages to at least two, typically three to four, of the
EU/associated beneficiary country institutes. Moreover, for each one of the eight NZ covered
in the call, there is breadth and depth of expertise among both the EU and associated country
institutes and among the ICPC institutes. The consortium also involves the International
Livestock Research Institute (ILRI) in Nairobi and two SMEs, each with a specific role to
play in achieving the projects objectives.
The ICONZ consortium will be coordinated by Mark Eisler at the University of Edinburgh,
who has previous experience of coordination of an EU Concerted Action (ICPTV) and of
several other multi-partner international collaborative projects in Europe and Africa funded by
the EC and DFID (UK). A secretariat established in Edinburgh comprising the coordinator
and an executive assistant will be responsible for day to day management and coordination of
the consortium. Management and coordination will reflect the decisions of the ICONZ
Management Board chaired by the Coordinator and comprising leaders of all twelve work
packages, as shown in the following table:
WP#
1
2
3
11
WP Title
Project Management & Coordination
Map Global Research on Neglected Zoonoses
Knowledge & Information on Neglected
Zoonoses
Improve & Develop Disease Control Tools
Bacterial zoonoses cluster
Small ruminant / dog cluster
Pig-associated parasite cluster
Vector-borne disease cluster
Socioeconomic & institutional aspects
Messaging, cultural aspects & traditional
knowledge
Technology Transfer & Training
12
Communication & Dissemination
4
5
6
7
8
9
10
WP Leader
Mark Eisler
Jim Scudamore
Jakob Zinsstag
Lead institution
University of Edinburgh
University of Liverpool
Swiss Tropical Institute
Stanny Geerts
Ignacio Moriyón
Franck Boué
Sonia Alfonso
Charles Waiswa
Alex Shaw
Helena Ngowi
ITM, Antwerp
University of Navarra
AFFSA
Eduardo Mondlane University
Makerere University
Avia-GIS
Sokoine University of Agriculture
Maria Vang
Johansen
Sue Welburn
University of Copenhagen
University of Edinburgh
Each work package leader has extensive expertise and experience in the area of his or her
work package, and is affiliated to an ICONZ partner institution with a leading international
reputation in the field concerned. This expertise, experience and reputation comprehensively
covers all eight of the NZ listed in the call. Five of the work package leaders are women.
Work package leaders will be responsible for the coordination of activities within their
respective work packages, with the assistance of the coordinator and secretariat. Key to the
coordination of these activities will be themed stakeholder workshops as described in section
B1.3(i) Overall Strategy of the Work Plan. Work package leaders will interact with each
other, particularly within the thematic groupings shown in Figure 2 (p. 14), and with
individual ICONZ participants contributing towards their work packages (summary
information shown in Table 1.3d).
UEDIN also will be responsible for Communication and Dissemination of ICONZ activities
and outputs both within the consortium and externally. All available media will be used to
promote the cohesiveness of the consortium and to maximise synergy within it, including
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physical meetings, virtual meetings by teleconferencing, an active website with downloadable
reports and newsletters, discussion forums, and by physical copies of communications and
newsletters to anyone requiring them.
Another important role in maintaining the consortium as a whole will be coordination of
technology transfer and training within ICONZ. These activities will be led by the University
of Copenhagen that has extensive capability and an outstanding track record in this area
through the DBL training programme. Also of note in this respect are the online International
Animal Health MSc programme run by the University of Edinburgh in partnership with
Makerere University and the new Masters in Public Health at Eduardo Mondlane University
to which the University of Minho and the Swedish Institute for Infectious Disease Control
will make significant contributions.
The ICONZ consortium includes eight ICPC institutes. These institutes, in Mali, Morocco,
Mozambique, Nigeria, South Africa, Tanzania, Uganda and Zambia, all share mutual benefits
with more than one of the EU and Associated Country participants in ICONZ through long
standing North-South collaborative linkages. The ICPC institutes also enjoy strong SouthSouth collaborative linkages, both within the West, East and South African regions, and
across regions through the activities of various networks and organisations such as AU-IBAR,
CWGESA, FAO, ICPTV, PACE, OIE etc.
The two SME participants in the ICONZ bring particular expertise to the consortium from the
commercial research sector. Avia-GIS is a Belgian SME founded in 2001 that specializes in
the collection, processing and analysis of spatial information in relation to livestock and
disease, and also economics assessment of zoonotic disease control in humans and animals.
Lab901 develops and refines technology for molecular diagnostics of human and animal
diseases, including zoonoses. Both these participants work closely with researchers and see
engagement in ICONZ as essential to their business development plans.
i) Sub-contracting: None of the work is to be sub-contracted by the participant responsible
for it.
ii) Other countries: None of the participants requesting EU funding is based in a country that
is outside the EU, and is not an Associated country, and is not on the list of International
Cooperation Partner Countries.
iii) Additional partners: There are no as-yet-unidentified participants in the project.
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B2.4. Resources to be committed
The consortium will have access to sufficient resources to implement the tasks specified in the
work plan to achieve the objectives of ICONZ. All participants are major organisations of
international renown, well resourced in terms of personnel, equipment and infrastructure and
already working on various aspects of control of NZ in developing countries. For this reason
there will be few major items of capital expenditure from the EC contribution to the ICONZ
budget, most of which will be used for personnel costs, travel, consumables and minor items
of equipment. The ICONZ work programme will be supported by a number of resources that
will complement the EC contribution. Committing additional resources will enable the
consortium to improve disease control through an integrated approach using funds from the
EC together with significant funding from other sources.
UEDIN will undertake PCR screening of > 10,000 cattle for T. b. rhodesiense in Uganda in
partnership with MAK under ‘Stamp Out Sleeping Sickness’ (www.sleepingsickness.org;)
providing an operational research platform for ICONZ (DFID: €150,000). UEDIN will
contribute use of a fully equipped category 3 molecular facility for molecular diagnostics and
epidemiology to ICONZ. Resources, materials and lessons learned from a public engagement
award for animal health and human health messaging (Wellcome Trust: €200,000) will
complement ICONZ. The UEDIN online MSc in International Animal Health for which 15
studentships are available for African veterinary and related professionals for 2008 to 2011,
may also contribute to ICONZ staff development and contribute to building a global
community for zoonoses research (Commonwealth Commission: > €200,000).
ICONZ is a multi-partner project based around delivering scientific innovation and public
engagement that demands significant management and other inputs by UEDIN. Budgetary
support is requested for 10% of the Coordinator salary for time that will be dedicated to for
ICONZ coordination and management. Support is also required for a full-time ICONZ
administrator (50% management, 50% other costs) to be based with the Co-ordinator who will
manage the project secretariat, assist with and ensure deliverables (D1.1-1.6) such as
Management Board and Advisory Council meetings and scientific and financial reports. This
post is a new position dedicated to ICONZ. Professor Sue Welburn at UEDIN, for whom 10%
salary is required for dedicated time, will lead WP12 (Communication and Dissemination;
other costs), to which the administrator will also provide support in providing deliverables
(D12.1-12.9), including the ICONZ website, data archive, newsletters, scientific meeting
reports, NZ control guidelines etc. Deliverables (D1.1-1.6, D12.1-12.9) will incur significant
non-salary management (D1.1-1.6) and other (D12.1-12.9) costs including management
meetings and scientific workshop organisation, meeting reports, website design and
maintenance, newsletter editing and production, press releases, etc.
ITM will contribute institutional funds (€50,000) towards ICONZ costs, including an ELISA
reader (€15000) and RT-PCR (€25000) and support a workshop on tools for zoonoses control
under WP4 (Belgian Development Cooperation: €25,000).
UCPH facilitates the Cysticercosis Working Group in Eastern and Southern Africa
(CWGESA) in promoting communication and coordination of integrated research and control
activities to combat cysticercosis. The department performs an annual course on advanced
research methodology for overseas students and runs a M.Sc. programme on Parasitology.
The WP 11 (technology transfer and training) led by UCPH has been set to implement 5 tasks
within the five year period. As this WP is one of the overarching WPs it involves all 22
partners in the full five year period. Its objective is to build capacity in African countries at all
levels (from researchers to livestock keepers and householders). Deliverables include
inventory of currently available relevant training courses, development and implementation of
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at least 4 training courses, development of electronic learning modules on specific diseases,
GIS and interventions. In order to achieve these deliverables UCPH has requested a part-time
salary for the WP coordinator (other costs). Additionally, included in the WP 11 budget will
be the cost of workshops and courses, travel funds (as substantial travel is expected), salary
for technical assistance to produce and test specific educational packages, facilitators at local
level to develop and test toolkits, and educational materials (other costs).
AFSSA will contribute the full facilities of its LERRPAS laboratory in Nancy.
UCBL will contribute institutional funds to ICONZ (€105,600) and use of a category 3
laboratory, cell culture unit and biochemical, immunological and molecular biology facilities.
FLI will contribute use of a fully equipped category 3 laboratory equipped for PCR and RTPCR for molecular diagnostics and epidemiology (VNTR-typing) for bovine TB (value of
contribution c. €200,000). FLI will provide software for molecular typing of mycobacterial
isolates funded by a National Zoonotic Research Programme (€24 000).
UMINHO will develop a Masters in Public Health at UEM (see below), promoting active
teaching/learning and student self-awareness for lifelong learning. UMINHO and KI will hold
a 2-week annual module for epidemiological design for NZ for African and/or European
country researchers. UMINHO will contribute laboratory classes in diagnosis of infectious
diseases. UMINHO will interact on-line and in Mozambique and with UEDIN to integrate
lusophone Mozambican students in the programme. A PhD studentship to support ICONZ is
under negotiation (Portuguese Science Foundation: €47,520).
UNAV will contribute PCR equipment (€40,000) and antigen preparation kit: bio-safety area
with incubators and centrifuges (€200,000). ICONZ EC budget will purchase consumables for
brucellosis diagnosis, vaccine quality control (WP4) and follow-up tests (WP5).
KI will contribute to the MSc in Public Health at UEM (see under UMINHO) and support
ICONZ with a range of facilities (from sequencing to proteomics). KI will contribute to
ICONZ with support from SIDA: (i) collaboration with UEM on bovine TB, cysticercosis and
RVF (SIDA 2008 to 2009: €247,000) and (ii) MAK for M. tuberculosis (SIDA 2008 to 2009:
€100,000). These collaborations involve PhD joint studentships with Karolinska Institutet. KI
has fully equipped P2-P4 laboratories for zoonoses. For TB work SMI has the National
Reference Laboratory, and WHO “supranational” TB reference laboratory for drug
susceptibility surveillance with equipment for diagnosis and susceptibility testing; facilities
for P3 work with TB; equipment for genome sequencing, microarray studies and mass spec.
STI will contribute to ICONZ with financial support from Swiss National Science Foundation
(€300,000) and the Wellcome Trust (€200,000, ongoing) to contribute to bovine tuberculosis
research and the building of an Afro-European network of cooperation.
ULIV will provide ICONZ with access to the University and National Centre for Zoonosis
Research computers and systems (c. €10,000 per project year).
LCV Full laboratory facilities, infrastructure and vehicles will be provided for ICONZ use.
IAVH2 will purchase a field vehicle (€15,000), ELISA plate reader (€5,000) and computers
(€3,500) from EC funds, as well as travel (€65,500), consumables (€30,460); total cost
€119,460. IAVH2 will provide a fully equipped biosafety laboratory. Linkages with the
Ministries of Agriculture and Health will be exploited for field investigations.
UEM will launch a Masters programme in Public Health in 2009 with a focus on zoonoses to
which KI and UMINHO will contribute. UEM will provide a fully equipped laboratory for
ICONZ use including electrophoresis equipment, ELISA reader, sonicator, PCR machine,
centrifuges etc. Vehicles will be provided for fieldwork.
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NVRI-VOM Will provide a bacteriology and serology lab with PCR and electrophoresis
facilities. Vehicles will be provided for fieldwork.
MAK will provide full molecular biology laboratory facilities and vehicles for fieldwork.
SU will provide support for training, communication and dissemination in epidemiological
modelling of NZ. Regional datasets on tuberculosis will be made available.
SUA Hosts the Cysticercosis Working Group in Eastern and Southern Africa (CWGESA)
secretariat and the DANIDA-funded Cross-Disciplinary Risk Assessment of Taenia solium
Cysticercosis in Eastern and Southern Africa (CESA). DBL and DANIDA provide office
equipment, LCD projector, laptop computer, screen and large battery pack for messaging
campaigns in rural areas not served with electricity. Vehicles will be provided for fieldwork.
UNZA Will provide essential equipment (biosafety cabinets, PCR machines etc.). Associated
projects funded by VLIR-IUC (Flemish aid) and DBL-CHRD (Denmark) will provide a range
of lab equipment (value €40,000). Vehicles will be provided for fieldwork.
AVIA-GIS will strengthen its Multi-terra data storage system providing computational backup, acquire a fast computation processing box, and purchase additional GIS software licenses
(ESRI and IDRISI packages) total estimated value € 24.800 from EC funds. AVIA-GIS will
contribute the full computing power and specialist expertise of its permanent collaborators.
Lab901 will make available 2 TapeStations for fully automated DNA, RNA or protein gel
electrophoresis delivering results in 10 minutes (value: €50,000) and collaborate with ICONZ
participants in optimising their use for PCR-based diagnosis of NZ.
ILRI is an unfunded partner in ICONZ, with an annual US$40M in international donor
funding (including EU and bilateral funding from EU member states). A project is under
negotiation with the Portuguese Government to work on porcine cysticercosis in Mozambique
(US$ 150,000 p/a). ILRI will provide lab facilities and expertise for collaborative support of
ICONZ. A vehicle will be provided for ICONZ use.
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B3. Potential Impact
B3.1. Expected impacts listed in the work programmes
ICONZ is expected to have a major impact on the implementation and effectiveness of
controls for the NZ in developing countries. This will result in a reduction in the incidence of
these diseases in the developing countries of Africa with the potential to extend the
programmes to Asia and S America at later stages. A reduction in the level of NZ will meet
the objectives of the FP7 work programme by improving human and animal health, improving
the livelihoods of the poorest communities, contributing to the reduction of poverty and the
Millennium Development Goals.
B3.1(i) CONTRIBUTION TOWARDS THE EXPECTED IMPACTS LISTED IN THE WORK
PROGRAMME
A successful outcome to ICONZ will be increased awareness of the burdens and significance
of the NZ and the availability of cost effective and practical strategies for their control.
ICONZ will provide a logical progression through a number of stages necessary to develop
control strategies for the NZ. These stages run concurrently in terms of the mapping of
research, collection of information and the delivery of new and improved control tools. By
providing acceptable, validated and stakeholder endorsed methodologies for gap analysis,
information gathering, assessment of burdens and evaluation of tools, this project will make a
major contribution to the delivery of the objectives of the FP7 work programme.
An overview of current worldwide research activities will reduce duplication of effort, lead to
a more effective use of resources and limited funds, encourage synergies and enable major
gaps in research to be identified and filled. This will enable more targeted research
programmes to be introduced and efforts made to obtain appropriate funding either from
within this project or from other donor agencies in order to strengthen the programmes and
fill the gaps.
ICONZ will ensure the availability of more comprehensive and validated information on the
epidemiology and distribution of each disease. By involving all stakeholders and utilising the
expertise in research institutes around Europe and in developing countries it will be possible
to produce detailed summaries for each disease.
Current estimates of the burden of these diseases in humans and livestock are inadequate and
new methods need to be developed. ICONZ will play a very important role in providing
detailed information of the burdens in animals and humans associated with each disease in
different circumstances. Standardised methodologies and models will be developed. The
availability of these methodologies for determining burden and cost (e.g. standardised way of
determining the disability weights due to a particular infection) will be a major contribution
and enable more detailed analysis of costs and benefits to be made. The provision of high
quality validated scientific evidence demonstrating the burdens imposed by the NZ will act as
a stimulus to policy makers and donor agencies to consider the importance of these diseases.
ICONZ will provide details of the current tools for surveillance, diagnosis, treatment and
prevention of NZ and identify whether new tools are needed for more effective control. The
development of cost effective diagnostic tools applicable and easy to use in the field will lead
to better understanding on the distribution of the diseases. Other tools which may become
available include vaccines and improved veterinary medicines in general although it must be
recognised that existing tools properly deployed in effective strategies may be acceptable
without the need for new expensive technological developments. For some zoonoses the tools
already exist and control is relatively simple provided there is a desire to take action.
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The project will develop and evaluate strategies for the prevention, control and elimination of
the NZ using existing tools and where appropriate incorporating the use of newly developed
tools. Innovative measures involving integrated controls, inter-programme and inter-sectoral
activities will be explored and developed to ensure the effective use of human and financial
resources. To be successful the strategies must based on case studies or/and small scale pilot
programmes, which can be evaluated to assess their effectiveness in reducing the levels of
disease and consequent burdens on the population. The evaluation will include an assessment
of sociological and cultural as well as economic aspects. Case studies and pilot projects will
provide the evidence that new measures are cost-effective. The project will be instrumental in
providing better access to the information on control measures which can be used by decision
makers in developing countries. One of the most important outcomes will be the ability to
tackle zoonoses as a group rather than as individually. Results can then be used to inform
policy making and decision taking by medical and veterinary authorities in the developing
countries, enabling the authorities to justify the investment necessary to implement control
strategies.
The outcome will be the delivery and implementation of clear, rational and cost effective
sustainable strategies to optimise the control of NZ. ICONZ will work in partnership with all
stakeholders to ensure that the information is made available in a format which can be utilised
by national governments to develop their policies to control the diseases and to securing
commitment at the national level. The establishment of a broad consortium involving
researchers in developing countries will promote information and technology transfer and
training, especially for surveillance, diagnostic tests and control strategies thereby supporting
and integrating research from Europe with that in the developing ICPC.
ICONZ will have a major impact by ensuring full participation of all stakeholders including
government (directors of both livestock and health services), district officials, traditional and
religious authorities and representatives of the general population. An inter-sectoral (human
and animal health) and trans-disciplinary (reaching all actors across each discipline) approach
will also be introduced. The project intends to avoid the potential pitfall of presenting
communities with a ready-made case and programme, which is apparently accepted while not
really meeting the community’s real needs and wishes.
It will be essential to provide an opportunity for the community to express themselves and for
effective dialogue to take place. Consulting stakeholders throughout the project is an iterative
process and will result in the achievement of greater understanding of the impact of the NZ.
This is an issue where the role of women in the society involved will be crucial to success
especially the need to involve women’s groups both in the development of the programmes
and in their implementation at a local level. The analysis of the cultural and social impact of
the diseases and the proposed control measures will provide a basis for deciding how to
engage the local population in the programmes.
B3.1(ii) STEPS THAT WILL BE NEEDED TO BRING ABOUT THESE IMPACTS
To be successful in bringing about the impact required by this work programme a number of
general steps are required. An innovative approach will be developed by tackling zoonoses as
a group, rather than as individual diseases. There is the possibility of tackling the disease
either on a production system or a host species approach. The integrated approach will also
enable the most effective use of resources.
Criteria will be established for conducting the various analyses with appropriate links to other
groups such as the ERA-Net and the ETPGAH. Information on the NZ will be collected in a
standardised format and validated. Methodologies for gap analysis and calculation of the
burdens will be developed along with where appropriate models which should be available for
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all to use. Preliminary outputs from the models will provide a detailed indication of the
burdens resulting for each of the NZ included in this project.
A rational methodology will be needed to identify the current tools and then to assess where
there are gaps and where there is potential to develop new or improved control tools. The
collection of information using a standardised questionnaire will make a major contribution
by ensuring the collection of high quality information to initiate the process. An analysis of
this information for each neglected zoonosis will identify those areas where full details are not
available. Additional work can then be implemented to fill these gaps.
The development and improvement of disease control strategies applicable to different parts
of the developing world is a critical component of the project. Policy makers, research funders
and other stakeholders will be involved in all these processes. The outputs will be discussed
with the interested parties which will include in particular; many of these groups will be
involved with the project as stakeholders and with the proposed governance arrangements for
the project.
Pilot projects will be designed to assess the control strategies and the various methods for
implementation. This will involve developing the methods for implementation which may be
carried out joint medical/veterinary teams during household visits, with a common
infrastructure and shared resources (transport, cold chain, diagnostics, sampling). The pilot
projects will consider how to integrate the information on control of the NZ into existing
medical primary care and veterinary extension service provision. Within the pilot control trial,
a full societal economic assessment will be conducted, which should include human, nonhuman benefits, monetary and non-monetary benefits, and the full benefits – including local
and international trade and other disease impacts, such as on tourism via wildlife. As a result
the full societal returns from the intervention could be calculated.
The involvement of women both as researchers and policy makers will be important for the
success of the project. In many countries women’s groups lead in this area of influence. The
project will identify in areas where pilot projects or case studies are introduced local women’s
groups and involve them in the design and running of the pilots. Input from women’s groups
will assist in developing the most appropriate methods for communication and publicity for
these projects when they are extended to more regional or national areas.
Technology transfer and training will be delivered in a number of ways. The overall objective
is to facilitate technology transfer and provide training opportunities either in developing
ICPC or in EU laboratories to enable scientists and policy makers to respond to the problems
of the NZ. Personal contacts will be valuable; knowledge and training will be offered to the
participants from developing countries and information will be provided. The diverse skills
and resources of the participating laboratories will be available to the participants through the
different work packages. This will be advantageous for the transfer of technology between
laboratories at an EU and developing ICPC beneficiary level. Existing disease and
geographical networks will be strengthened and where necessary new networks will be
established. The networks will involve representatives from the veterinary and medical
sectors to ensure that policies are developed which cover both people and animals.
B3.1(iii) WHY THIS CONTRIBUTION REQUIRES A EUROPEAN APPROACH
NZ are a world wide problem especially in the developing world. To have the greatest impact
the project must take a European and global approach and focus research at both an EU and
developing ICPC level. It is impractical for a project of this importance and scope to be
limited to a local or national level as the capacity, expertise and funding which are necessary
for research, collaboration and coordination do not exist. The European approach is the most
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appropriate at which to coordinate the extensive and multidisciplinary activities of this
project.
Much of the current expertise in the field of NZ is concentrated in the EU. This knowledge
and experience of working with the NZ is not evenly distributed around Europe or within the
wider international community. The value of carrying out the work at the European level is
illustrated by the membership of the consortium which will bring together organisations from
within Member States, INCO and third countries.. Each group will bring to the project
expertise on a specific disease or in specialist technical or scientific areas such as sociology,
economics parasitology, epidemiology, risk analysis, and modelling.
The inclusion of non EU Member States in this project supports the stated EU aim of
involving developing countries and recognises the importance they have to play as part of the
consortium. The collaboration which ICONZ will generate will ultimately lead to the
improved control strategies for the NZ throughout the world.
B3.1(iv) HOW ACCOUNT IS TAKEN OF OTHER NATIONAL OR INTERNATIONAL RESEARCH
ACTIVITIES
This project builds on the recommendations from WHO, DFID and ETPGAH which
identified the research programmes required for the NZ. It also takes into account the research
activities in a number of EU Member States which are funded by national authorities as well
as the EU. The consortium brings together a range of expertise for each of the NZ and
includes individuals and groups who are leaders in their fields and have a wide knowledge of
current research programmes.
To ensure a coordinated approach the consortium will work closely with other groups and
organisations involved with the NZ both in Europe and in the developing ICPCs. This
includes Networks of Excellence such as MED-VET-NET, the ERA-Net EMiDAon emerging
and major infections of animals and the ETPGAH. Active steps will be taken to collaborate
with other organisations and groups as appropriate.
The mapping of research will provide detailed information on research into NZ around the
world. In order to obtain this information ICONZ will need to work closely with international
and national funding agencies. These close links will enable the national and international
research activity to be monitored and incorporated into this project. These links will enable
the project to be up to date on international and national activities.
B3.1(v) ASSUMPTIONS AND EXTERNAL FACTORS THAT MAY DETERMINE WHETHER THE
IMPACTS WILL BE ACHIEVED
The proposed project should provide the support needed to enable the stakeholders especially
decision makers in developing countries, to actively support programmes to control and
prevent NZ. Provided the information is obtained, validated and presented in a suitable
format, the impacts will be achieved. Management of a large group will be a challenge but the
expertise to deal with each of the NZ and the more generic issues is available from within the
multidisciplinary consortium.
B3.2. Dissemination and/or exploitation of project results, and
management of intellectual property
ICONZ outputs will be disseminated through the activities of two specific work packages:
WP11: Technology Transfer and Training, and WP12: Communication and Dissemination.
The dissemination of the expected outputs from ICONZ will be achieved through a number of
methods. Publications both in peer and non-peer reviewed journals will enable the technical
outputs to be made available. Presentations at conferences and workshops will be encouraged.
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Briefing documents for policy makers, on (i) the size of the problem and (ii) options for
control will be prepared and widely disseminated through a range of channels.
A web site will be important for dissemination of knowledge especially as it will be used by
all the stakeholders who represent the whole spectrum of interests. Information and progress
reports will be posted on the web site.
ICONZ will lend support to an international Scientific Advisory Committee on NZ, as
recommended by the WHO/DFID Animal Health Programme meeting (Geneva, 2005). It is
anticipated that this body will be established as an output of a follow up meeting to be held by
WHO in Nairobi in November 2007, and supported by WHO, FAO and OIE.
ICONZ will contribute to an International Resource Centre if established under the aegis of
WHO, FAO and OIE, as recommended by the Joint WHO and DFID Animal Health
Programme meeting held in Geneva in September 2005. The International Resource Centre
would be responsible for gathering existing educational and advocacy material for public
engagement in zoonotic diseases, such as booklets, leaflets, handbooks, health education
posters etc.
Dissemination via the Project Management Board and the Advisory Council will be of
specific importance especially as the main stakeholders will be represented on these
governing bodies for the project. ICONZ will bring together partners from small biotech
companies, academia, research institutes, and policy makers it will result in a partnership
covering the whole chain from innovative research through development, production,
manufacture to the distribution of more effective tools for controlling animal disease. Using
this partnership, the knowledge and results can be disseminated throughout the chain very
quickly and very effectively.
Close links will be established with policy makers in developing countries. Specific links with
the proposed ERA-Net for infectious diseases of animals will be of importance as this will
permit access to the Member State organisations which fund research. By disseminating the
information on gaps and technologies in this way it is anticipated that a more coherent and EU
wide funding policy will be developed to ensure best use of limited resources.
STAKEHOLDER FORUM
ICONZ will enable the establishment of a stakeholder forum to gather all relevant
stakeholders from both the public and private sectors that have an interest in NZ. The forum
which will be a multi-disciplinary consortium including industry, public and private research
institutions, universities, public authorities, livestock producers, civil society, consumers,
funding bodies, third countries and international organizations (e.g. OIE, FAO, ILRI). It will
be focussed on developing the project. Ultimately this should increase coherence and obtain
the critical mass required to achieve increased effectiveness in the development and
distribution of new vaccines and diagnostic tests.
A Stakeholder Forum will be established with representation from all interested parties. The
active and committed involvement of all the Stakeholders is vital to the success and
credibility of the project. Participation is envisaged from constructive Stakeholders
representing various groups but it will be important to develop specific criteria for the
involvement of Stakeholders where no specific European or representative organisation
exists. Good communication channels will be established using electronic methods and an
active up to date website for those who are not invited to participate at meetings. A separate
list will be maintained of the Interested Parties to facilitate communications. Members of
existing stakeholders networks in the various neglected zoonoses targeted in the call such as
CWGESA, EchinoNet, ETPGAH, ICPTV, MED-VET-NET, MZCP, SWGL, and GCCC (see
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Appendix I. List of abbreviations) will be contacted through these networks and invited to
join the ICONZ stakeholder forum.
A stakeholder database will be maintained as will information on all interested parties. This
will enable the rapid transfer of information and knowledge when necessary. Intellectual
property issues will addressed in a Consortium Agreement that will be put in place among
partners.
A final stakeholder conference or workshop at the end of the project will present and
disseminate the outputs from ICONZ to all stakeholders and members of the public with an
interest. Specific meetings will be convened with policy makers in the developing countries to
update them on the outputs and discuss practical application of the project methodologies and
conclusions.
MIRROR GROUPS
ICONZ will encourage the formation of ICPC partner Mirror Groups, with membership
drawn from key stakeholder groups at all levels, including government ministerial, human and
animal health implementation agencies, research organisations, NGOs and community-based
organisations. The importance of the role of women in both the veterinary profession and the
communities concerned will be reflected in the composition of these groups. The Mirror
Groups will facilitate the interface with national programmes and reflect regional interests, as
well as promote inter-sectoral collaboration between human, animal and environmental health
agencies. Their roles and tasks are co-operation/co-ordination with national regulatory
initiatives, co-operation/co-ordination with national R&D initiatives and to provide opinion
and advice to the ICONZ Management Board when setting goals and targets, inputs are
expected in relation to the strategic research agenda, implementation of the action plan,
integration of control and prevention strategies, networking activities, training and
communication and dissemination of knowledge and technologies.
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B4. Ethical Issues
ICONZ will involve collection of human data, but not of human biological specimens. All
principles set out in the Declaration of Helsinki and the Council for International
Organisations of Medical Sciences (CIOMS) International Ethical Guidelines for Biomedical
Research Involving Human Subjects will be strictly adhered to. Ethical clearance will be
sought from the ethical committee of the National Medical Board in each country involved.
Protocols will include: study justification; objectives; statement of hypotheses/research
questions; assurance that sample sizes are statistically determined to capture sufficient
subjects to reach valid conclusions; that participant confidentiality is assured; and that there
are no conflicts of interest. ICONZ participants will be supported to attend research ethics
courses and local permissions will be sought prior to project implementation.
ETHICAL ISSUES TABLE
Yes
Informed Consent
• Does the proposal involve children?
• Does the proposal involve patients or persons not able to give consent?
• Does the proposal involve adult healthy volunteers?
• Does the proposal involve Human Genetic Material?
• Does the proposal involve Human biological samples?
• Does the proposal involve Human data collection?
Research on Human embryo/foetus
• Does the proposal involve Human Embryos?
• Does the proposal involve Human Foetal Tissue / Cells?
• Does the proposal involve Human Embryonic Stem Cells?
Privacy
• Does the proposal involve processing of genetic information or personal
data (e.g. health, sexual lifestyle, ethnicity, political opinion, religious or
philosophical conviction)
• Does the proposal involve tracking the location or observation of people?
Research on Animals
• Does the proposal involve research on animals?
• Are those animals transgenic small laboratory animals?
• Are those animals transgenic farm animals?
• Are those animals cloning farm animals?
• Are those animals non-human primates?
Research Involving Developing Countries
• Use of local resources (genetic, animal, plant etc)
• Benefit to local community (capacity building i.e. access to healthcare,
education etc)
Dual Use
• Research having potential military / terrorist application
No
x
x
x
x
x
x
x
x
x
x
x
x
x
x
x
x
x
x
x
I CONFIRM THAT NONE OF THE ABOVE ISSUES APPLY TO MY PROPOSAL
Informed consent Meetings with stakeholders will explain the project and information will be
provided to study participants to include study objectives, rights (e.g. participation is
voluntary), foreseen risks, benefits, and general recommendations. Information will be
provided in English, Kiswahili or local language and the respondent will reiterate consent in
the presence of a witness to confirm comprehension. Confidentiality will be ensured and
written informed consent will be sought from all adult participants (or, in the case of children,
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their parents or guardians). Information collected will only be used for the purpose of the
study and there are no genetic results being sought in this study. Confidentiality and Privacy
will be assured during recruitment; individual data will be coded and any images will be
masked (Council for International Organisations of Medical Sciences (CIOMS)).
Confidentiality agreements will acknowledge individual rights to privacy. Research on
animals will be with clearance from the relevant national authorities and with owner consent.
Field sampling of animals will be statistically determined and experimental studies will be
conducted in accordance with the Directive 86/609/EEC. Animals may be treated as part of
planned interventions and will be treated if they show clinical signs of disease during the
course of studies by trained veterinary personnel and with consent of the owner. Research
involving developing countries - The project has explicit objectives to build diagnostic and
control capacity, to train individual health personnel, to foster effective working partnerships,
and to provide training packages for diagnosis, epidemiology and control of NZ in developing
countries (Council for International Organisations of Medical Sciences (CIOMS), Nuffield
Council of Bioethics). The expected benefits to the general population will be much more
knowledge gained on zoonoses. (See References - Ethical Issues ).
Issues raised in the ethical issues review report
The proposed project is entitled Integrated control of neglected zoonoses: improving human
health and animal production through scientific innovation and public engagement, acronym
ICONZ. The ICONZ project addresses the Work Programme topic KBBE-2007-1-3-09:
Neglected zoonoses in developing countries: Integrated approach for the improvement of
their control in animals. The focus of the proposed project is control of the reservoir of
neglected zoonoses in domestic and wild animals. Fully in keeping with the work programme
topic, and the proposed project title, the ICONZ proposal involves no collection of biological
specimens of any kind whatsoever from human subjects, nor any pharmaceutical, medical or
surgical interventions or trials on humans, neither adult nor children, and neither healthy
volunteers nor patients. The proposed work will also encourage intersectoral collaboration
between the veterinary, medical and public health services in the participating ICPCs.
Specifically, the research will be fully cognisant of relevant data collected by the existing incountry medical services, including importantly metrics of levels of disease in the population,
and of interventions practiced by these medical services. Through appropriate intersectoral
collaborations, combined measures of disease in man and livestock will be developed in an
attempt to quantify the overall burden, and through the results of the research integrated
intervention packages may be suggested in which existing human health interventions may be
co-delivered with animal health interventions. However, the responsibility for delivering and
assessing human health interventions in the participating ICPCs will remain with the incountry medical authorities before, during and after the ICONZ project.
The following sections highlight some of the issues (or non-issues) that may be relevant for
the ethical screening of the project proposal.
INFORMED CONSENT
DOES THE PROPOSAL INVOLVE CHILDREN?
No. The proposal per se does not involve children. The proposal does give consideration to
integrated intervention packages where animal health interventions might be combined with
existing medical interventions, one of which might be childhood vaccination, as in the
example on page 18 of part B of the proposal:
‘(i) intersectoral approaches for joint animal and public health interventions, for example
inter-ministerial cooperation for societal benefit of brucellosis control, combining anthrax
and childhood vaccination, and coordinated cysticercosis control in man and animals;’
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In this example, and throughout the project, the proposed integrated intersectoral approaches
entail harmonisation of administration of animal and human vaccinations in communities,
rather than the current practice of each sector working independently. However, the project
would not be responsible for instigation a programme of childhood vaccination where one did
not already exist, or changing it in any substantive manner from the modality already under
implementation by the in-country medical authorities prior to the inception of the project.
The proposal is also cognisant of the importance of children in terms of their role as ‘future
cooks, carers, milkers and livestock keepers’, and hence the importance of education in the
control of neglected zoonoses, but again the activities proposed under the project proposal per
se do not involve children. The impact of the ICONZ activities will be nevertheless be of
particular benefit to children through progress towards achieving millennium goals 3, 4 and 5.
DOES THE PROPOSAL INVOLVE ADULT HEALTHY VOLUNTEERS?
In the original stage 2 proposal document this question was answered ‘yes’, but on closer
examination it would appear that the correct answer is ‘no’. The reason for the original
affirmative answer was that collection of data by questionnaire survey (see below) would be
conducted on adults, who would do so voluntarily, and would generally be healthy
individuals. However, the ICONZ coordinators now realise that this is almost certainly not
what was meant by the original question, and it must be emphasised that the proposal does
not involve collection of biological specimens, pharmaceutical trials or medical or surgical
procedures on any human subjects whatsoever.
DOES THE PROPOSAL INVOLVE HUMAN DATA COLLECTION?
Yes, but only in the collection of household data by questionnaire survey or similar. It must
be re-emphasised that this proposal does not involve collection of biological specimens of
any kind whatsoever from human subjects. Collection of information by questionnaire or
similar (e.g. key-informant interviews or focus-group discussions) will be entirely on a
voluntary basis, and will be conducted by trained enumerators from local communities under
the supervision of qualified and experienced sociologists and socio-economists with relevant
backgrounds to ensure appropriate ethical standards are maintained at all times.
Finally, the ICONZ project proposal Part B states on P. 78 ‘written informed consent will be
sought from all adult participants (or, in the case of children, their parents or guardians)’.
This wording is possibly over-cautious, in that this would be the usual practice for the
consortium members involved in research involving human subjects, but in fact none of the
activities proposed under ICONZ involve adult participants (other than respondents in
questionnaire surveys or similar) and certainly not children.
PRIVACY
It is not anticipated that personal data will be collected/processed under the Project.
However, in case any is the Coordinator will ensure that the Consortium Agreement to be
entered into amongst the project partners will include provision that any personal data
ingathered will be processed only for the limited purposes of the project and in accordance
with relevant national data protection legislation.
DOES THE PROPOSAL INVOLVE PROCESSING OF GENETIC INFORMATION OR PERSONAL DATA
(e.g. health, sexual lifestyle, ethnicity, political opinion, religious or philosophical conviction)
The proposal involves collection of data by questionnaire survey or similar (eg key-informant
interviews or focus-group discussions). These will encompass questions about health and
ethnicity, but not sexual lifestyle, political opinion, or philosophical conviction. Religious
conviction will be of interest only insofar as it affects people’s dietary habits, which is
obviously of relevance to risk of acquiring food-borne neglected zoonoses such as taeniosis.
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DOES THE PROPOSAL INVOLVE TRACKING THE LOCATION OR OBSERVATION OF PEOPLE?
The proposal will involve collection of geo-referenced data at household level: (i) livestockowning households, where livestock keeping and interventions to control neglected zoonoses
are investigated, and (ii) households (whether or not they own livestock) to be included in
questionnaire surveys. Strictly speaking these activities cannot be described as either tracking
or observation of people.
RESEARCH ON ANIMALS
DOES THE PROPOSAL INVOLVE RESEARCH ON ANIMALS?
The title of topic KBBE-2007-1-3-09 is ‘Neglected zoonoses in developing countries:
integrated approach for the improvement of their control in animals’, and the funding scheme
is a large collaborative project; this by definition involves research on animals. However, the
animal subjects of the research are existing populations of domestic and wild animals in the
ICPCs participating in the project, rather than experimental animals specifically kept for the
purposes of the research. Research on these animal populations will be conducted with
clearance from the relevant national authorities in keeping with national and EU ethical
standards and with owner consent. Field sampling of live animals, generally limited to
collection of blood specimens for diagnostic purposes, will be statistically determined and
experimental studies will be conducted in accordance with the Directive 86/609/EEC.
Animals may be administered veterinary pharmaceutical products approved for use by the
veterinary authorities in the ICPCs as part of planned interventions, and individual animals
will be treated therapeutically by trained veterinary personnel if they show clinical signs of
disease during the course of these studies, and always with consent of the owners.
RESEARCH INVOLVING DEVELOPING COUNTRIES
USE OF LOCAL RESOURCES (GENETIC, ANIMAL, PLANT ETC)
The topic by definition concerns animals in developing countries, and specifically integrated
approaches for the control of neglected zoonoses in animals; local resources, i.e. domestic and
wild animals, are the subjects of interventions for the control of zoonotic diseases. The
potential beneficiaries of this activity are the human populations living among these animals
in the ICPCs, whose health, socioeconomic conditions and hence livelihoods will be
improved by the control of neglected zoonoses. Moreover, the zoonotic diseases targeted by
ICONZ, namely anthrax, rabies, brucellosis, bovine TB, zoonotic trypanosomiasis,
echinococcosis, cysticercosis and leishmaniasis, have adverse health and welfare implications
for the reservoir animal populations, and hence their control will lead to improvements in the
value of these resources for local communities.
BENEFIT TO LOCAL COMMUNITY (CAPACITY BUILDING I.E. ACCESS TO HEALTHCARE,
EDUCATION ETC)
As well as the benefits to local communities described above under Use of local resources,
the ICONZ project has explicit objectives to build diagnostic and control capacity, to train
individual health personnel, to foster effective working partnerships, and to provide training
packages for diagnosis, epidemiology and control of NZ in developing countries (Council for
International Organisations of Medical Sciences (CIOMS), Nuffield Council of Bioethics).
The expected benefits to the general population will be much more knowledge gained on
zoonoses.
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B5. Gender Issues
B5.1. Actions related to the project consortium
The ICONZ consortium includes leading women scientists and will ensure activities are
undertaken by female researchers where feasible. The socio-cultural context of zoonoses and
associated control strategies dictates that primarily women should be involved in contacting
households for research, public awareness and teaching communities how to prevent disease.
Prevention of disease often involves measures such as cooking and hygiene (cysticercosis),
washing of wounds (rabies), boiling milk (bovine tuberculosis and brucellosis) where women
are primarily responsible for implementation or teaching children and supervising family
members. The consortium is aware of the importance of zoonotic disease control to women in
poor communities (see below); female researchers, students and field workers are particularly
interested in the topic. We will build on this to create a greater awareness of the subject within
our institutions and to involve and recruit female staff.
B5.2. Actions aimed at a wider public
B5.2(i) EVENTS ORGANISED IN SCHOOLS OR UNIVERSITIES
Consortium members have experience of targeting schoolchildren for livestock disease
control in Africa and have produced appropriate literature, which is important for diseases
such as rabies, tapeworm, cysticercosis and cystic echinococcosis. As future cooks, carers,
milkers and livestock keepers the preventive messages are particularly important for girls. At
the university level, the scientists involved in this project have a long track record of
promoting graduate and particularly postgraduate education of women both in EU and ICPCs
in the science and social science disciplines relevant to NZ.
B5.2(ii) IMPLICATIONS FOR WOMEN IN ICPCS
Achieving gender equality in the developing world is one of the most daunting measures to
reduce poverty identified by the MDGs; goal 3 seeks to “promote gender equality and
empower women” and the larger correlation between unequal treatment of women and global
poverty is irrefutable. Women who cannot escape poverty because of pervading cultural
constraints often set into motion a cycle of poverty that can extend to children and to
generations of families. The work to be undertaken under this project will directly involve and
benefit women. Zoonotic diseases pose a particular burden on women in poor societies. In
poor societies, women are responsible for milking cattle, own and rear animals and can keep
the money they make from selling milk and milk products, eggs and their own animals.
• Livestock provide women with an independent source of both cash and protein which they
can directly channel to their children and themselves. Livestock thus support both
maternal and child health and empower women (MDGs 3, 4 and 5).
• Livestock are a popular form of investment for women who participate in credit
programmes, and are widely favoured by NGOs as a means of reducing poverty.
• Because of their work milking and rearing livestock, which involves close contact with
the animals, women are particularly at risk and are often those infected.
• Where zoonoses lower livestock productivity, especially milk yield, this directly lowers
women’s incomes and their and their children’s protein intake.
• Livestock are an integral part of poor households’ coping strategy, to be sold in times of
need or disaster, such as ill health or harvest failure. Where zoonoses lead to livestock
deaths, this not only stops output from these animals but removes this vital source of
emergency funds. The burden of coping then usually falls on the household’s women.
• Women are the primary carers for sick household members, many zoonoses are gradual
wasting diseases leading to long term disability and care needs.
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Appendix I: References
References - General
Alvar, J., Yactayo, S. & Bern C. (2007) Leishmaniasis and poverty, Trends in Parasitolgy 22, 552557.
Bechir, M., Schelling, E., Wyss, K., Daugla, D. M., Daoud, S., Nicolet, J., Tanner, M. & Zinsstag, J.
(2004) Approche novatrice des vaccinations en santé publique et en médecine vétérinaire chez
les pasteurs nomades au Tchad: expériences et coûts. Médecine Tropicale 64, 497-502.
Carabin, H., Budke, C. M., Cowan, L. D., Willingham, A. L. III, Torgerson, P. R. (2005) Methods for
assessing the burden of parasitic zoonoses: echinococcosis and cysticercosis. Trends in
Parasitolgy 21, 327-333.
Coleman, P. (2002). Zoonotic diseases and their impact on the poor. In: Perry, B. D., Randolph, T. F.,
McDermott, J. J., Sones, K. R. & Thornton, P. K. (2002) “Investing in animal health research to
alleviate poverty”. International Livestock Research Institute (ILRI), Nairobi.
Coleman, P.G., Fevre, E. M. & Cleaveland, S. (2004) Estimating the public health impact of rabies.
Emerging Infectious Diseases 10,140-142.
Eisler, M. C., Torr, S, Coleman, P. G., Morton J. & Machila, N. (2003) Integrated control of ticks and
tsetse. Trends in Parasitolgy 19, 341-345.
European Parliament resolution on Major and Neglected Diseases in Developing Countries,
(2005/2047(INI)), Adopted Thursday, 8 September 2005 – Strasbourg.
Holveck, J. C., Ehrenberg, J. P., Ault, S. K., Rojas, R., Vasquez, J., Cerqueira, M. T., IppolitoShepherd, J., Genovese, M. A. & Periago, M. R. (2007) Prevention, control, and elimination of
neglected diseases in the Americas: Pathways to integrated, inter-programmatic, inter-sectoral
action for health and development. BMC Public Health 7, 6.
Kayali, U., Mindekem, R., Hutton, G., Ndoutamia, A. G. & Zinsstag, J. (2006) Cost-description of a
pilot parenteral vaccination campaign against rabies in dogs in N'Djamena, Chad. Tropical
Medicine and International Health, 11, 1058-1065.
Knobel, D. L., Cleaveland, S., Coleman, P. G., Fèvre, E. M., Meltzer, M. I., Miranda, E. G., Shaw, A.,
Zinsstag, & J. Meslin, F. X. (2005) Re-evaluating the burden of rabies in Africa and Asia.
Bulletin of the World Health Organization 85, 360-368.
Kuboki, N., Inoue, N., Sakurai, T., Di Cello, F., Grab, D.J., Suzuki, H., Sugimoto, C. & Igarashi, I.
(2003). Loop-mediated isothermal amplification for detection of African trypanosomes. Journal
of Clinical Microbiology 41, 5517–5524.
Lembo, T., Niezgoda, M., Velasco-Villa, A., Cleaveland, S., Ernest, E. & Rupprecht, C. E. (2006).
Evaluation of a direct, rapid immunohistochemical test for rabies. . Emerging Infectious
Diseases 12, 310-313.
Lutumba, P, Robays, J, Miaka, C, Kande, V, Simarro, P. P, Shaw, A. P. M., Dujardin, B. & Boelaert,
M (2005) Efficience de différentes stratégies de détection de la Trypanosomiase Humaine
Africaine à T. b. gambiense. Tropical Medicine and International Health 10, 347-356
Machila, N., Emongor, R., Shaw, A. P., Welburn, S. C., McDermott, J. J., Maudlin, I. & Eisler, M. C.
(2007) A community education intervention to improve bovine trypanosomiasis knowledge and
appropriate use of trypanocidal drugs on smallholder farms in Kenya. Agricultural Systems 94,
261-272.
Ngowi, H.A., Tolma, E.L., Kassuku, A.A., Mlozi, M.R.S., Mlangwa, J.E.D., Carabin, H. &
Willingham, A.L. III (2007). Using the PRECEDE model to plan a health promotion strategy
for control of Taemia solium infections in northern Tanzania. International Journal of Health
Promotion & Education 45, 41-48.
Notomi, T., Okayama, H., Masubuchi, H., Yonekawa, T., Watanabe, K., Amino, N. & Hase, T.
(2000). Loop-mediated isothermal amplification of DNA. Nucleic Acids Research 28, E63-e63.
86
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Odiit, M., Shaw, A., Welburn, S. C., Fèvre, E. M., Coleman, P. G., & McDermott, J. J. (2004)
Assessing the patterns of health-seeking behaviour and awareness among sleeping-sickness
patients in eastern Uganda. Annals of Tropical Medicine and Parasitology 98, 339-348.
Pawlowski, Z., Allan, J. and Sarti, E. (2005) Control of Taenia solium taeniasis/cysticercosis: From
research towards implementation. International Journal for Parasitology 35, 1221-1232.
Roth, F., Zinsstag, J., Orkhon, D., Chimed-Ochir, G., Hutton, G., Cosivi, O., Carrin, G. & Otte, J.
(2003) Human health benefits from livestock vaccination for brucellosis: case study. Bulletin of
the World Health Organization 81, 867-876.
Schelling, E., Diguimbaye, C., Daoud, S., Nicolet, J., Boerlin, P., Tanner, M. & Zinsstag, J. (2003)
Brucellosis and Q-fever seroprevalences of nomadic pastoralists and their livestock in Chad.
Preventive Veterinary Medicine 61, 279-293.
Schelling, E., Wyss, K., Diguimbaye, C., Bechir, M., Ould-Taleb, M., Bonfoh, B., Tanner, M. &
Zinsstag, J. (2008) Towards integrated and adapted health services for nomadic pastoralists and
their animals: A North-South partnership. In: Hirsch Hadorn G, Hoffmann-Riem H, BiberKlemm S, Grossenbacher W, Joye D, Pohl C et al., editors. Handbook of Transdisciplinary
Research. Heidelberg: Springer, 277-291.
Shaw, A. P. M. & Sibanda, L. (2000) Evaluation of Selected Livestock Research Themes.
Consultancy report prepared for DFID by Landell Mills Ltd. Landell Mills, Trowbridge.
Shaw, A. P. M. & Cattand P (2001) Analytical tools for planning cost-effective surveillance in
gambiense sleeping sickness. Médecine Tropicale 61, 412-421.
Welburn, S. C., Coleman, P. G., Maudlin, I., Fèvre, E. M., Odiit M. & Eisler, M. C. (2006) Crisis,
what crisis? Control of Rhodesian sleeping sickness. Trends in Parasitolgy 22, 123-128.
WHO (2002). Future Trends In Veterinary Public Health. WHO Technical Report Series 907, Geneva.
WHO (2006). The Control of Neglected Zoonotic Diseases: a route to poverty alleviation. Report of a
joint WHO/DFID-AHP Meeting. 20 and 21 September 2005, WHO Headquarters Geneva, with
the participation of FAO and OIE. WHO, Geneva. Pp. 62.
Zinsstag, J. (2007) Animal health research. Science 315, 1193.
Zinsstag, J., Roth, F., Orkhon, D., Chimed-Ochir, G., Nansalmaa, M., Kolar, J. & Vounatsou, P.
(2005) A model of animal-human brucellosis transmission in Mongolia. Preventive Veterinary
Medicine 69, 77-95.
Zinsstag, J., Schelling, E., Wyss, K. & Mahamat M. B. (2005) Potential of cooperation between
human and animal health to strengthen health systems. Lancet 366, 2142-2145.
Zinsstag, J., Schelling, E., Roth, F., Kazwala, R. R. (2006) Economics of bovine tuberculosis. In:
Thoen CO, Steele JH, Gilsdorf MJ, editors. Mycobacterium bovis infection in animals and
humans. London: Blackwell Science, 68-84.
Zinsstag, J., Schelling, E., Roth, F., Bonfoh, B., de-Savigny, D. & Tanner, M. (2007) Human Benefits
of Animal Interventions for Zoonosis Control. Emerging Infectious Diseases 13, 527-531.
References - Ethical Issues
World Medical Association. Declaration of Helsinki. Edinburgh, 2000.
Council for International Organisations of Medical Sciences (CIOMS). International Ethical
Guidelines for Biomedical Research Involving Human Subjects. Geneva, 2000.
Council of Europe. Convention on Human Rights and Biomedicine. Oviedo, 1997.
UNESCO. Universal Declaration on Bioethics and Human Rights. Paris: UNESCO, 2005
Nuffield Council of Bioethics. The ethics of research related to healthcare in developing countries.
London: Nuffield Foundation, 2002.
Directive 86/609/EEC (The well-being of laboratory animals)
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Appendix II: List of abbreviations
AFSSA
ASARECA
AU-IBAR
CWGESA
DALY
DBL
DCEP
DFID-UK
DG-SANCO
EchinoNet
EFSA
ETPGAH
FAO
GCCC
GIS
ICONZ
ICPC
ICPTV
ILRI
LAMP
MED-VET-NET
MDG
MZCP
NZ
OIE
PACE
SADC
SACEMA
SME
SWGL
TB
WHO
French Food Safety Agency (Agence Française de Sécurité
Sanitaire des Aliments)
Association for Strengthening Agricultural Research in Eastern
and Central Africa
African Union – Inter-African Bureau of Animal Resources
Cysticercosis Working Group in Eastern and Southern Africa
Disability-Adjusted Life Year
Danish Centre for Health Research and Development
Danish Centre for Experimental Parasitology
UK Department for International Development
Directorate General for Health and Consumer Affairs
EU Echinococcosis Network
European Food Standards Agency
European Technology Platform for Global Animal Health
Food and Agriculture Organization of the United Nations
Global Campaign for Combating Cysticercosis
Geographical information systems
Integrated Control of Neglected Zoonoses
International Cooperation Partner Country
EU Concerted Action on Integrated Control of Pathogenic
Trypanosomes and their Vectors
International Livestock Research Institute
Loop-mediated isothermal amplification
European Network of Excellence for Zoonoses Research
Millennium Development Goal
Mediterranean Zoonoses Control Programme
Neglected zoonoses
World Organisation for Animal Health
Pan African Control of Epizootics
Southern African Development Community
South African Centre of Excellence for Epidemiological
Modelling and Analysis
Small or medium sized enterprise
WHO Scientific Working Group on Leishmaniasis
Tuberculosis
World Health Organization of the United Nations
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Appendix III: Detailed Gantt Chart
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