November 2014 Advanced Healing Lotion

Advanced Healing Lotion
November 2014
Thinning/aging skin is a concern for almost 80 million Americans and growing
very rapidly, creating a market for anti-aging products that will reach $114
billion next year
PATHOLOGY
Dermal thinning and atrophy
Decrease in hydration
Dramatic decrease in capillary loops (microcirculation)
Decrease in skin oxygen tension
PREVALENCE
Every day 10,000 Baby Boomers turn 65 now thru 2030
The 79-million-member Baby Boomer generation
accounts for 26% of the total U.S. population
Baby boomers seeking to keep the dreaded signs of
aging at bay, will push the U.S. market for anti-aging
products to more than $114 billion by 2015
TYPICAL APPEARANCE
To effectively treat these skin conditions we established diabetic skin as a
model since elevated blood sugar induces premature aging
Average sugar
consumption of 150 lbs
per year for adults
According to the American Heart Association (AHA), “the average adult in the United
States takes in 22 teaspoons of added sugar a day, or a whopping 150 pounds a year,
while teens pile in 34 teaspoons a day.”
Sugar can make skin dull
and wrinkled and leads to
AGE production
Experts now believe that a lifetime of overeating sugar can make skin dull and wrinkled.
At blame is a natural process known as glycation, in which the sugar in your bloodstream
attaches to proteins to form harmful new molecules called advanced glycation end
products (AGEs for short). The more sugar you eat, the more AGEs you develop.
AGEs damage collagen
and elastin and leave skin
vulnerable to sun damage
that causes aging
AGEs accumulate and damage adjacent proteins, mostly collagen and elastin, the protein
fibers that keep skin firm and elastic. Moreover, AGEs deactivate your body's natural
antioxidant enzymes, leaving you more vulnerable to sun damage—still the main cause of
skin aging. By the time you reach your mid-30s a build-up of sun damage, environmental
oxidative stress, hormonal changes, and the accumulation of AGEs begins to take its toll
at the same time your ability to repair the damage declines.
Diabetics, due to blood
sugar, can have up to 50
times more AGEs!
One group that knows all too well sugar's ravaging effects: people with diabetes, who—
because they can suffer from years of undetected high blood sugar—often show early
signs of skin aging. In fact, it is estimated that diabetics can have up to 50 times the
number of AGEs in their skin as those who don't have diabetes.
Sources: Prevention.com, SkinInc.com, Elle.com, NBCnews.com, doctoroz.com
SkinClinical is a proprietary, patented formulation created under an NIH grant
for preventing and healing skin conditions associated with diabetes, with
proven results in treating conditions of thinning/aging skin
SkinClinical was scientifically developed and clinically proven to:
Reduce AGEs
Promote healthy, resilient skin
Improve overall appearance
Promote collagen formation
Increase skin thickness and elasticity
Decrease trans-dermal water loss
Increase microcirculation and oxygenation
Heal severely dry, cracked, damaged skin
Heal moderate to severe diabetic ulcers
The results are dramatic.
Sample before and after pictures from NIH funded study
BEFORE TREATMENT (DAY 0)
AFTER TREATMENT (DAY 45)
In fact, SkinClinical has been vetted by some of the most reputable
diabetes-related associations and pharmacy wholesalers/retailers in the
U.S. and Mexico
Approved and presented at national events of:
Approved for sale at the following retailers/wholesalers:
Our core management team has a strong background and extensive
experience in health and beauty products
Herminio Llevat (CEO)
Mr. Llevat began his career in Brand Management at Procter & Gamble and later at the DuPont Company. In addition to his role as CEO of
Thibiant Beverly Hills, Mr. Llevat is also the founder and CEO of True North Equity, LLC, a private investment firm focused on the acquisition
and creation of brands with high growth potential in health, beauty and personal care. He received a BA degree from Harvard and an MBA
from Harvard Business School.
Harry Glassman M.D. (Medical Director)
Dr. Glassman received his M.D. degree from Hahnemann Medical College, Plastic and Reconstructive Surgery training at U.C.L.A. Medical Center and
Clinique du Belvedere in Paris, France. Dr. Harry Glassman has been practicing plastic surgery in Beverly Hills for the past thirty years and has achieved
recognition and worldwide esteem as a noted authority in his field . He has used his talents to enhance the appearance of some of the most famous
people in the world and to reconstruct birth defects, damage from injuries, and defects caused by cancer. Dr. Glassman is the author of numerous
scientific papers and textbook chapters on the correction of facial aging, eyelid surgery, and breast implantation and explanation (implant removal). Dr.
Glassman has been featured in news segments on NBC, ABC, Nighltline and 20/20. He maintains his expertise, keeping current on the latest procedural
advancements and breakthroughs. He is a distinguished specialist in state-of-the-art plastic surgical procedures including: facelift, brow lift, eyelid
surgery, nasal surgery, endoscopic surgery, laser resurfacing, chin and cheek augmentation, liposuction, breast augmentation, and breast reduction.
Founder of highly regarded NOVA Surgicenter and Medical Director of Thibiant Institute of Aesthetic Medicine.
Niv Carmi (Vice President)
Management consulting at Booz Allen Hamilton in Latin America for 9 years, with an industry focus in consumer goods, sales and marketing.
BS in Mechanical and Industrial Engineering from ITESM and MBA from the Kellogg School of Management at Northwestern University.
Dominique Rivera (Brand Manager)
Sales, brand and market management experience at P&G Mexico. BA in International Management from Anahuac University, an International
Markets Certificate from the ESCIP University in France and a Business and Marketing Strategy Certificate from the University of Bremen in Germany.
While our advisory board combines the scientific depth and experience to
support the development of our products
Krys Bojanowski, Ph.D
Clinical investigator with laboratories in Santa Paula and Santa Clara California. Previously a scientist at the life Science Division of Lawrence Berkeley
National Laboratory, in the Department of Surgery at Harvard Medical School, and the National Cancer Center in Tokyo, Japan. Earned a BS in
Biochemistry and Molecular Biology, a Masters in Molecular and Cellular Pharmacology, as well as a Masters in Marketing in Pharmaceutical Industry,
and a PhD (cum laude) in Molecular and Cellular Pharmacology. Received numerous scientific awards and honors and has been a principal investigator
on 7 research grants from the National Institute of Health, including 2 from the National Institute of Aging. Co-authored 25 peer reviewed scientific
articles and book chapters and has numerous patents.
Dr. Martin J. Abrahamson
Dr. Abrahamson is an Associate Professor of Medicine at Harvard Medical School and Medical Director at the Joslin Diabetes Center in Boston,
Massachusetts. Dr. Abrahamson is board certified in internal medicine and in endocrinology, diabetes and metabolism, and is a Fellow of the College of
Physicians of South Africa. He has been cited in Boston Magazine as one of Boston’s top doctors on numerous occasions.
Stephen Palacios
Mr. Palacios leads Cheskin Added Value’s Hispanic market practice group serving Fortune 100 companies. Mr. Palacios has over 15 years of business
development and consulting experience and has led marketing initiatives and organizational consulting efforts for global brand leaders in consumer
goods, financial services, retail and media. He is a frequent national speaker on the U.S. Hispanic Market, including keynoting national conferences. Mr.
Palacios has been cited in the LA Times, NY Times and has appeared on ABC News Nightline and PBS. He is a blogger on The Huffington Post’s Latino
Voices. Mr. Palacios holds a BA from Saint Joseph's University (PA), where he was Valedictorian and an MA from American University, where he was
awarded a Fellowship.
APPENDIX
Clinical Study to Evaluate the Effectiveness of
a Topical Product on Diabetic Skin Condition
Clinical Study to Evaluate the Effectiveness of
a Topical Product on Crepey Neck Skin
National Institutes of Health Clinical Study
Testimonials
SBD.4 – The ingredient behind the results
“Clinical Study to Evaluate the Effectiveness of a Topical
Product on Diabetic Skin Condition” - Results
1. Objective Findings
By Moisture Meter 100% of subjects improved in hydration immediately
By Cutometer 90% of subjects improved firmness in 24 hours
By TruAge Scanner 70% of subjects improved in AGEs (Anti-Glycation End Products) by week 4.
When compared to baseline for TruAge Reading and AGE Reading, treated subjects showed a
numerical improvement from baseline and trend wise data suggest a significant improvement
from baseline and trend wise data suggest a significant improvement from untreated test sites.
By Cutometer and Moisture Meter applied to the face: 80% of subjects responded positively
immediately in firmness, elasticity and hydration (23% mean improvement in firmness, 63%
mean improvement in hydration)
“Clinical Study to Evaluate the Effectiveness of a Topical
Product on Diabetic Skin Condition” - Results
2. Responses to Subject Questionnaire
Improved the texture/
smoothness of facial skin
Improved the radiance/
luminosity of facial skin
Improved the crepeyness of
arm skin
Improved the texture/
smoothness of arm skin
Improved the overall
appearance of arm skin
Improved the texture/
smoothness of leg skin
“Clinical Study to Evaluate the Effectiveness of a Topical
Product on Diabetic Skin Condition” - Results
Image Analysis – Skin Dryness
BASELINE
Variable
Dryness Score
WEEK 4
Baseline
Week 4
% Reduction
38
19
50%
“Clinical Study to Evaluate the Effectiveness of a Topical
Product on Diabetic Skin Condition” - Results
Image Analysis – Skin Texture
WEEK 4
BASELINE
Variable
Texture/Roughness Score
Baseline
Week 4
% Reduction
62.8
31.9
49.2%
“Clinical Study to Evaluate the Effectiveness of a Topical
Product on Diabetic Skin Condition” - Results
Conclusion
“After two and four weeks of repeated applications, the majority of
subjects agreed or strongly agreed with all statements regarding
efficacy on the face, arms and legs. Additionally, after four weeks,
100% of subjects responded favorably to improved “texture /
smoothness” and “radiance / luminosity”
on the face, arms and legs.
In conclusion, SkinClinical showed the potential to improve skin
appearance and condition on the face, dorsal forearm and lower
lateral leg when evaluated by subjective and objective measures ”
APPENDIX
Clinical Study to Evaluate the Effectiveness of
a Topical Product on Diabetic Skin Condition
Clinical Study to Evaluate the Effectiveness of
a Topical Product on Crepey Neck Skin
National Institutes of Health Clinical Study
Testimonials
SBD.4 – The ingredient behind the results
“Clinical Study to Evaluate the Effectiveness of a Topical
Product on Crepey Neck Skin” - Results
1. Objective Findings
By Clinical Grading 78% of subjects improved in skin texture by 4 weeks
By Clinical Grading 82% of subjects improved in skin texture by 8 weeks
By Clinical Grading 65% of subjects improved in skin crepeyness by 8 weeks
By Cutometer 77% of subjects improved in firmness by 8 weeks
By Cutometer 74% of subjects improved in elasticity by 8 weeks
2. Responses to Subject Questionnaire
79% of subjects improved in firmness by 8 weeks
73% of subjects improved in texture/smoothness by 8 weeks
68% of subjects improved in appearance of crepeyness by 8 weeks
“Clinical Study to Evaluate the Effectiveness of a Topical
Product on Crepey Neck Skin” - Results
Before and After Photos
BASELINE
WEEK 8
“Clinical Study to Evaluate the Effectiveness of a Topical
Product on Crepey Neck Skin” - Results
Conclusion
“Significant improvements in neck skin’s texture, elasticity, firmness,
and crepeyness as revealed by visual and instrumental assessment
results. Additionally, consumer perception corroborated these findings
after eight weeks of use.”
APPENDIX
Clinical Study to Evaluate the Effectiveness of
a Topical Product on Diabetic Skin Condition
Clinical Study to Evaluate the Effectiveness of
a Topical Product on Crepey Neck Skin
National Institutes of Health Clinical Study
Testimonials
SBD.4 – The ingredient behind the results
Clinical Study – NIH (National Institutes of Health)
PHASE I: Scientific Data
Significant improvement in skin oxygenation measured with Radiometer ® TCM30
No increase in trans-epidermal water loss after 30 days measured by cyberDERM RG-1 Evaporimeter
Significant improvement in skin thickness measured by Ultrasound Cortex DermaScan C
Significant improvement in skin elasticity measured by indentometry with Gas-bearing Dynamometer GBE1
PHASE II: Clinical Trial by Springhouse Skin Research Center
Improvement in diabetic skin structure
Clinical improvement of elasticity, dryness and appearance, as well as small wound healing
Found to be especially effective with high response rate for diabetic skin
Found in comparison study to be superior to the leading diabetic skin care product Neoteric
Results – NIH Clinical Study
(case study 1)
Before and After Photos
BEFORE TREATMENT (DAY 0)
AFTER TREATMENT (DAY 15)
Results – NIH Clinical Study
(case study 2)
Before and After Photos
DAY 0
DAY 15
DAY 30
DAY 45
Results – NIH Clinical Study
(case study 3)
Before and After Photos
BEFORE TREATMENT (DAY 0)
AFTER TREATMENT (DAY 45)
Results – NIH Clinical Study
(case study 4)
Before and After Photos
BEFORE TREATMENT (DAY 0)
AFTER TREATMENT (DAY 45)
Additional Before and After Photos
Treated with
Treated with
Leading Brand
Treated with
Treated with
Leading Brand
APPENDIX
Clinical Study to Evaluate the Effectiveness of
a Topical Product on Diabetic Skin Condition
Clinical Study to Evaluate the Effectiveness of
a Topical Product on Crepey Neck Skin
National Institutes of Health Clinical Study
Testimonials
SBD.4 – The ingredient behind the results
The efficacy of this formulation is best expressed by the
Testimonials of those who have used it
Crepey / Thinning Skin
“My 78-year old mother had paper-thin skin that was constantly tearing. It was heartbreaking to see, so I started scouring the internet for any
topical products that might fortify her skin. After much searching, I found SkinClinical and contacted the company to buy some. I was very happy to
find that the cream quickly helped my mother and, after a month's use, the amount of tearing she experienced was reduced by about 50%.
Separately, my husband (who is non-diabetic but has thin skin on his lower legs) tried the cream, and found he had many fewer cuts and gashes.”
L. Greenberg – Pasadena, CA
“My daughter was undergoing chemo/radiation treatment when I ran out of my facial moisturizer. She suggested I try the lotion she was using for
her skin during treatment, SkinClnical Healing Lotion. I am eighty nine years old and after several weeks I noticed a change taking place with my
skin. My face was no longer scaly and dry, the red patches have gone away and my skin actually feels thicker. I just ordered my second tube of
SkinClinical Healing Lotion, it’s an amazing product.”
L. May – Encinitas, CA
Diabetes
“I have diabetes and am recently going through menopause, which causes my skin to be extremely dry. After applying my first sample of
SkinClinical I recovered the elasticity in my skin overnight! I’ve tried everything and my heels and legs have never felt and looked so good. After two
days I still can’t believe the improvement I’m seeing on my skin!”
L. Bistre – Mexico City, Mexico
“My husband Paul is diabetic 72 years old and since 2005 he developed pressure sores and his feet need extra care. We have been using
SkinClinical and my husband’s feet became more supple and the pressure sores went away, scaling was reduced to minimum, no other product
worked that well!”
Alison B. – Santa Paula, CA
The efficacy of this formulation is best expressed by the
Testimonials of those who have used it (continued)
Psoriasis
“I have suffered from psoriasis for eight years now. My psoriasis manifests and creates breakouts according to my level of stress. As it breaks out,
the itching starts and the psoriasis get worst over time. It was very frustrating for me, since I own a jewelry shop to show my clients the jewelry
when I had scales all over my hands. You can imagine how unattractive that was! After using all different types of lotions, a friend of mine
recommended SkinClinical. I saw results OVERNIGHT. I applied the lotion on my hands, and the next morning I didn't even notice until later that
afternoon that I had not itched or scratched my hands all day! Thank you SkinClinical, you have not only helped me but my business as well!”
S. Blancato – La Conner, WA
“Hi Harry!! Yes LOVE the product very much and Kim saw great results as well!!!”
Kris J. – Calabasas, CA
Eczema
“Highly recommended! I have eczema, my skin is very dry and I have to be careful not to use products with perfumes or harsh chemicals. I use this
product on my body and I never have any burning sensations as I do with other products. This product actually works from within the skin, not just
on the surface!”
A. Hollbrock – San Francisco, CA
Radiation Dermatitis
“I was diagnosed with a rare form of skin cancer which required 7 weeks of radiation treatment on my head, neck and ear. The area is very
sensitive and burns easily. I was given a sample of the Daily Therapy at my Radiation Oncologist's office. I am happy to say that this is the only
topical that helps with the discomfort. It is odor free, absorbs easily and has a cooling effect. I am now ordering from the website, can't wait for the
larger size. I am a true believer! Thank you.”
S. Andrews - Julian, CA
Wound Healing
“SkinClinical worked on my father marvelously. My dad has 78 stitches up his leg bypass and three of them would not heal, leading to infection and
much concern after there was no progress 2 weeks after surgery. I administered the lotion you sent while I was in NYC last week and to our great
surprise the wound healed within 3 days!!!! It completed sealing the wound, eliminated the infected fluid, and my dad was completed healed!!!
Thank you.”
P. Gabbard - El Paso, Texas
APPENDIX
Clinical Study to Evaluate the Effectiveness of
a Topical Product on Diabetic Skin Condition
Clinical Study to Evaluate the Effectiveness of
a Topical Product on Crepey Neck Skin
National Institutes of Health Clinical Study
Testimonials
SBD.4 – The ingredient behind the results
SBD.4 is based on a root extract from Angelica Sinensis, a plant used in
traditional Chinese medicine for thousands of years
SBD.4
The SBD.4 ingredient is extracted by a patented
method from a specific compartment of the
Angelica Sinensis roots.
This root compartment isolate contains the
combination of arginine, phosphorus,
α-hydroxy acids and carbohydrates along with
other organic phytochemicals and minerals.
This combination delivers a powerful healing
and nutritional supplementation to aged and
damaged skin by increasing microcirculation
and increasing oxygenation.
The efficacy of SBD.4, our proprietary phyto-angiostimulator ingredient, has
been studied and reported in international peer reviewed publications
SBD.4 activity shown effective in human dermal wounds in vivo.
Day 6
•Control Group - no wounds were closed
•SBD.4 Group - all wounds were bridged.
Day 16
•Dramatic difference between SBD.4 and control group post-wounding
Magnified cross-sections of the skin during the NIH study provide proof for
collagen formation and angiogenesis
LOW MAGNIFICATION
CONTROL
TREATED
CONTROL
TREATED
Control
Micro-Circulation
Control Collagen
Formation
(blue stain)
HIGH MAGNIFICATION
(red stain)
Increased Collagen
Formation
(blue stain)
Increased
Micro-Circulation
(red stain)
Pro-angiogenic effect of SBD.4 on developing vasculature
of zebrafish embryo
LOW MAGNIFICATION
HIGH MAGNIFICATION
(A) Control: live fluorescence
microscopy expressing
intersegmental blood vessels (ISV)
(white arrow) and
dorsal longitudinal anastomotic
vessels (DLAV) (red arrow)
(B) VRI (VEGFR tyrosine kinase inhibitor
II) reduced blood vessel formation in
ISV and DLAV
(C-F) VRI pretreated zebrafish embryos,
treated with 10 μg/ml SBD.4 (C), 30
μg/ml SBD.4 (D), 100 μg/ml SBD.4
(E), 300 μg/ml SBD.4 (F), 500 μg/ml
SBD.4 (G)