Solstas PMP FolderR9-OUT

Transcription

Solstas PMP FolderR9-OUT
Why Monitor Prescription Drugs? What is the Issue?
In a period of nine months, a tiny Kentucky county of fewer than 12,000 people sees a 53-year-old mother, her
35-year-old son, and seven others die by overdosing on pain medications obtained from pain clinics in Florida.1
In Utah, a 13-year-old fatally overdoses on oxycodone pills taken from a friend’s grandmother. A 20-year-old
Boston man dies from an overdose of methadone, only a year after his friend also died from a prescription drug
overdose.2
These events are not uncommon. Drug overdose death rates in the United States have more than tripled since
1990 and have never been higher. In 2008, more than 36,000 people died from drug overdoses, and most of
these deaths were caused by prescription drugs.3
When a physician is about to prescribe a potentially addictive or mind altering drug, whether it is a central
nervous system (CNS) depressant or stimulant, is it valuable to know what else the patient has not told you?
Here are some interesting points to consider.4
• Should a pain reliever be prescribed without a complete picture of the patient’s health history, including
knowledge of the potential presence of other prescription drugs?
• Do patients always tell you the truth about what antibiotics and other drugs they are taking?
• Do patients always tell you the truth about their alcohol consumption?
• Do patients always tell you the truth about any possible drugs they take that might give them a “good feeling”?
What are the consequences of patients giving you incomplete information and you never realizing it?
Patients frequently are not willing to share some practices or behaviors with their physicians. The physician
needs to perform some investigative work to identify potentially unhealthy practices. What happens when a
patient is using one or more CNS depressants and it is not identified by testing? Here are some facts to consider:
• There were nearly 2.1 million Emergency Room (ER) visits in 2009 for misuse or abuse of drugs.5
• Misuse of pharmaceuticals was involved in 1.2 million ER visits in 2009.5
• In 2009, nearly 200,000 medical emergencies resulting in ER visits were for drug-related suicide attempts.6
This is a list of CNS depressants that may be present with the drugs routinely prescribed. Are you ignoring
Oxycodone, Hydrocodone, Fentanyl, Carisoprodol, Meperidine, Ambien, Buprenorphine, ETG (4-5 day alcohol
biomarker), Tramadol, Nucynta? What are the consequences of not knowing?
A number of charts and graphs showing the statistics of drug overdoses and abuse are found in the subsequent
pages. Please contact your Solstas representative with further questions or inquiries.
References:
1. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. (2012). Policy Impact: Prescription
Painkiller Overdoses. Retrieved from http://www.cdc.gov/homeandrecreationalsafety/rxbrief.
2. O’Brien, K. Man fights what son could not. Boston Globe. (2008). Retrieved from
http://www.boston.com/news/local/articles/2008/01/12/man_fights_what_son_could_not/?page=1.
3. Centers for Disease Control and Prevention. Vital Signs: Overdoses of Prescription Opioid Pain Relievers—United States,
1999-2008. MMWR 2011;60:1-6. Retrieved from http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6043a4.htm.
4. Reddy, S. ‘I Don’t Smoke, Doc,’ and Other Patient Lies. The Wall Street Journal. (2013). Retrieved from
http://online.wsj.com/article/SB10001424127887323478004578306510461212692.html#articleTabs%3Darticle.
5. Substance Abuse and Mental Health Services Administration, Drug Abuse Warning Network, 2009: The DAWN Report: Highlights of the
2009 Drug Abuse Warning Network (DAWN) Findings on Drug-Related Emergency Department Visits. Retrieved from
http://www.oas.samhsa.gov/2k10/DAWN034/EDHighlights.htm.
6. Substance Abuse and Mental Health Services Administration, Drug Abuse Warning Network, 2009: National Estimates of Drug-Related
Emergency Department Visits. HHS Publication No. (SMA) 11-4659, DAWN Series D-35. Rockville, MD: Substance Abuse and Mental
Health Services Administration, 2011.
4380 Federal Drive, Suite 100
Greensboro, NC 27410
888-664-7601
www.solstas.com
4380 Federal Drive, Suite 100
Amps
Amps
Amps
Amps
Amps
Prescription Abuse Monitoring
(17 Panel)
Prescription Abuse Monitoring
(18 Panel)
Prescription Abuse Monitoring
(19 Panel)
66079
66080
66081
66082
66076
Prescription Abuse Monitoring
(16 Panel)
66075
66078
Prescription Abuse Monitoring
(12 Panel)
66074
Amps
Amps
Prescription Abuse Monitoring
(11 Panel)
66073
Prescription Abuse Monitoring
(15 Panel)
Amps
Prescription Abuse Monitoring
(10 Panel)
66072
66077
Amps
Prescription Abuse Monitoring
(9 Panel)
66071
Amps
Amps
Prescription Abuse Monitoring
(8 Panel)
66038
Prescription Abuse Monitoring
(14 Panel)
Amps
Prescription Abuse Monitoring
(7 Panel)
66089
Prescription Abuse Monitoring
(13 Panel)
Amps
Prescription Abuse Monitoring
(6 Panel)
66037
Amps
Description
Prescription Monitoring Profile
(5 Panel)
Order Code
Greensboro, NC 27410
888-664-7601
Barbs
Barbs
Barbs
Barbs
Barbs
Barbs
Barbs
Barbs
Barbs
Barbs
Barbs
Barbs
Barbs
Barbs
Benz
Benz
Benz
Benz
Benz
Benz
Benz
Benz
Benz
Benz
Benz
Benz
Benz
Benz
Benz
THC
THC
THC
THC
THC
THC
THC
THC
THC
THC
THC
THC
THC
THC
Cocaine
Cocaine
Cocaine
Cocaine
Cocaine
Cocaine
Cocaine
Cocaine
Cocaine
Cocaine
Cocaine
Cocaine
Cocaine
Methadone Opiates
Methadone Opiates
Methadone Opiates
Methadone Opiates
Methadone Opiates
Methadone Opiates
Methadone Opiates
Methadone Opiates
Methadone Opiates
Methadone Opiates
Methadone Opiates
Methadone Opiates
Methadone Opiates
Methadone Opiates
Oxy
Oxy
Oxy
Oxy
Oxy
Oxy
Oxy
Oxy
Oxy
Oxy
Oxy
Oxy
Oxy
Oxy
Cocaine Methadone Opiates Oxy
Poxy
Poxy
Poxy
Poxy
Poxy
Poxy
Poxy
Poxy
Poxy
Poxy
Poxy
Poxy
Bup
Bup
Bup
Bup
Bup
Bup
Bup
Bup
Bup
Bup
Bup
Tram
Tram
Tram
Tram
Tram
Tram
Tram
Tram
Tram
Tram
Tram
Mepr
Mepr
Mepr
Mepr
Mepr
Mepr
Mepr
Mepr
Mepr
Mepr
Fty
Fty
Fty
Fty
Fty
Fty
Fty
Fty
Fty
Soma
Soma
Soma
Soma
Soma
Soma
Soma
Soma
Zol
Zol
Zol
Zol
Zol
Zol
Zol
Tap
Tap
Tap
Tap
Tap
Tap
XTC
XTC
XTC
XTC
Pcp
Pcp
Pcp
Lude
Lude
PMP Panels
www.solstas.com
Drug Screen Cutoffs
ELISA
Screening
Cut Off
GC/MS or
LC/MS/MS
Quantitation
Cut Off
500 ng/ml
100 ng/ml
200 ng/ml
150 ng/ml
200 ng/ml
100 ng/ml
Cannabinoid metabolite
(marijuana/THC)
Cocaine (as benzoylecon)
50 ng/ml
150 ng/ml
15 ng/ml
100 ng/ml
Fentanyl
Meperidine/metabolite
2 ng/ml
200 ng/ml
10 ng/ml
100 ng/ml
Methadone/Metabolite (EDDP)
300 ng/ml
100 ng/ml
Methaqualone
300 ng/ml
150 ng/ml
Opiates (Codeine, morphine,
hydrocodone, hydromorphene)
300 ng/ml
100 ng/ml
Oxycodone
Phencyclidine
100 ng/ml
25 ng/ml
100 ng/ml
25 ng/ml
Propoxyphene
300 ng/ml
100 ng/ml
Tramadol
200 ng/ml
100 ng/ml
Ecstacy (MDA,MDMA,MDEA)
500 ng/ml
100 ng/ml
Heroin (6-am)
Ambien (Zolpidem)
10 ng/ml
20 ng/ml
10 ng/ml
100 ng/ml
Tapentadol (NUCYNTA)
200 ng/ml
Carisoprodol (Meprobamate, OMA)
100 ng/ml
100 ng/ml
Buprenorphine
10 ng/ml
10 ng/ml
Ethanol
ETG(Alcohol Metabolite)
.04 gms%
500 ng/ml
.04 gms%
500 ng/ml
SPICE
5 ng/ml *
1 ng/ml
Precription Monitoring
Amphetamine (amphetamine,
methamphetamines)
Barbiturate (amobarbital,
butabarbital, phenobarbital,
pentobarbital, secobarbital)
Benzodiazepines/metabolites
(alprazolam metabolite, flurazepam
metabolite, nordiazepam,
oxazepam, temazepam, triazolam
metabolite)
Specimen Validity Testing Profile
Creatinine
> 20 mg/dl
PH
4.5-9.0
Specific gravity
General Oxidants
<1.003
>200
* Screen by LC/MS/MS
4380 Federal Drive, Suite 100
Greensboro, NC 27410
888-664-7601
www.solstas.com
Drug Metabolism Chart (1 of 5)
Common/Brand Name
Generic
Parent Drug
Drug Metabolite(s)
Detection Period (€)
Reference Source
6-AM
Heroin
Diacetylmorphine
6-AM
2-4 hours after use
1
AceTam w/ Codeine
Codeine
Codeine
Hydrocodone, Norhydrocodone, Morphine
2-3 days after use
1
Actiq
Fentanyl
Fentanyl
Norfentanyl
Fentanyl (1 day),
Norfentanyl (up to 3 days)
1
ADAM
MDMA
Amphetamine
1-2 days after use
1
Adderall
Amphetamine
Amphetamine
1-2 days after use
1
Adepril
Amitriptyline
Amitriptyline
Nortriptyline
5-15 days after use
2
Alcohol
Ethyl Alcohol
Ethyl Alcohol
ETG
4 days after use
3
Alepam
Oxazepam
Oxazepam
1-14 days after use
1
Allegron
Nortriptyline
Nortriptylene
5-15 days after use
2
Alupram
Diazepam
Diazepam
Nordiazepam, Temazepam, Oxazepam
1-14 days after use
1
Amidon
Methadone
Methadone
EDDP
5-10 days after use
1
Amitril
Amitriptyline
Amitriptyline
Nortriptyline
5-15 days after use
2
Amrix
Cyclobenzaprine
Cyclobenzaprine
5-15 days after use
2
Anafranil
Clomipramine
Clomipramine
5-15 days after use
2
Anexsia
Hydrocodone
Hydrocodone
2-3 days after use
1
Angel Dust
Phencyclidine
Phencyclidine
10-20 days after use
1
Ansiolin
Diazepam
Diazepam
Nordiazepam, Temazepam, Oxazepam
1-14 days after use
1
Antideprine
Imipramine
Imipramine
Desipramine
5-15 days after use
2
Aspirin w/ Codeine
Codeine
Codeine
Hydrocodone, Morphine
2-3 days after use
1
Astramorph
Morphine
Morphine
Hydromorphone
2-3 days after use
1
Atensine
Diazepam
Diazepam
Nordiazepam, Temazepam, Oxazepam
1-14 days after use
1
Norhydrocodone, Hydromorphone
Ativan
Lorazepam
Lorazepam
1-14 days after use
1
Aventyl
Nortriptyline
Nortriptylene
5-15 days after use
2
Avinza
Morphine
Morphine
Hydromorphone
2-3 days after use
1
Balacet
Propoxyphene
Propoxyphene
Norpropoxyphene
5-10 days after use
1
Benzadrine
Amphetamine
Amphetamine
1-2 days after use
1
Benzphetaime
Methamphetamine
Methamphetamine
Amphetamine
1-2 days after use
1
Buprenex
Buprenorphine
Buprenorphine
Norbuprenorphine
2-4 days after use
1
Buprenorphine
Buprenorphine
Buprenorphine
Norbuprenorphine
2-4 days after use
1
Butalbital
Butalbital
Butalbital
2-20 days after use
1
Butrans
Buprenorphine
Buprenorphine
Norbuprenorphine
2-4 days after use
1
Carisoma
Carisoprodol
Carisoprodol
Meprobamate
2-3 days after use
4
Centrex
Prazepam
Nordiazepam
Oxazepam
1-14 days after use
1
Clonopin
Clonazepam
Clonazepam
7-Amino-Clonazepam
1-14 days after use
1
Cocaine
Cocaine
Cocaine
Benzoylecgonine
2-5 days after use
1
Codal-DH
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
References:
1 - "Clinical Toxicology Testing" A Guide for Laboratory Professionals - CAP Press
2 - WIKITOX
3 - allhealthsite.com
4 - drugs.com
€ -The biological half-life or elimination half-life of a substance is the time it takes for a substance to lose half of its pharmacologic activity, as per the MeSH definition.
In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ("plasma half-life") its steady-state.
The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, active
metabolites, and receptor interactions.
The detection periods noted are general and may noy apply for everyone.
4380 Federal Drive, Suite 100
Greensboro, NC 27410
888-664-7601
www.solstas.com
Drug Metabolism Chart (2 of 5)
Common/Brand Name
Generic
Parent Drug
Drug Metabolite(s)
Detection Period (€)
Reference Source
Codclear-DH
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Codeine Cough Syrup
Codeine
Codeine
Hydrocodone, Norhydrocodone, Morphine
2-3 days after use
1
Codimal-DH
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Co-Gesic
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Combunox
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Contin
Morphine
Morphine
Hydromorphone
2-3 days after use
1
Conzip
Tramadol
Tramadol
2-3 days after use
4
Cyndal-HD
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Cytuss-HC
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Darvocet
Propoxyphene
Propoxyphene
Norpropoxyphene
5-10 days after use
1
Darvon
Propoxyphene
Propoxyphene
Norpropoxyphene
5-10 days after use
1
Demerol
Meperidine
Meperidine
Normeperidine
1-2 days after use
4
Deprenyl
Selegilene
Selegilene
Amphetamine, Methamphetamine
1-2 days after use
1
Deprimin
Imipramine
Imipramine
Desipramine
5-15 days after use
2
Deprinol
Imipramine
Imipramine
Desipramine
5-15 days after use
2
Depsonil
Imipramine
Imipramine
Desipramine
5-15 days after use
2
Desoxyn
Methamphetamine
Methamphetamine
Amphetamine
1-2 days after use
1
Destim
Methamphetamine
Methamphetamine
Amphetamine
1-2 days after use
1
Detussin
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Dexedrine
Amphetamine
Amphetamine
1-2 days after use
1
Dextrostat
Amphetamine
Amphetamine
1-2 days after use
1
Diastat
Diazepam
Diazepam
Nordiazepam, Temazepam, Oxazepam
1-14 days after use
1
Didrex
Benzphetamine
Benzphetamine
Amphetamine, Methamphetamine
1-2 days after use
1
Dilaudid
Hydromorphone
Hydromorphone
2-3 days after use
1
Dipam
Diazepam
Diazepam
Nordiazepam, Temazepam, Oxazepam
1-14 days after use
1
Emprin w/ Codeine
Codeine
Codeine
Hydrocodone, Norhydrocodone, Morphine
2-3 days after use
1
Endal-HC
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Endep
Amitriptyline
Amitriptyline
Nortriptyline
5-15 days after use
2
Endocet
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Endodan
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Enovil
Amitriptyline
Amitriptyline
Nortriptyline
5-15 days after use
2
Etrafon
Amitriptyline
Amitriptyline
Nortriptyline
5-15 days after use
2
Exalgo
Hydromorphone
Hydromorphone
2-3 days after use
1
Faustan
Diazepam
Diazepam
Nordiazepam, Temazepam, Oxazepam
1-14 days after use
1
Fentanyl
Fentanyl
Fentanyl
Norfentanyl
Fentanyl (1 day),
Norfentanyl (up to 3 days)
1
Fentora
Fentanyl
Fentanyl
Norfentanyl
Fentanyl (1 day)
Norfentanyl (up to 3 days)
1
References:
1 - "Clinical Toxicology Testing" A Guide for Laboratory Professionals - CAP Press
2 - WIKITOX
3 - allhealthsite.com
4 - drugs.com
€ -The biological half-life or elimination half-life of a substance is the time it takes for a substance to lose half of its pharmacologic activity, as per the MeSH definition.
In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ("plasma half-life") its steady-state.
The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, active
metabolites, and receptor interactions.
The detection periods noted are general and may noy apply for everyone.
4380 Federal Drive, Suite 100
Greensboro, NC 27410
888-664-7601
www.solstas.com
Drug Metabolism Chart (3 of 5)
Detection Period (€)
Reference Source
Cyclobenzaprine
5-15 days after use
2
Butalbital
2-20 days after use
1
Fiorinal
Butalbital
Butalbital
2-20 days after use
1
Flexeril
Cyclobenzaprine
Cyclobenzaprine
5-15 days after use
2
G-Tuss
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Heroin
Heroin
Diacetylmorphine
6-AM
2-4 hours after use
1
Histinex-HC
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Histussin-HC
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Hycet
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Hycodan
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Hycomine
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Hydrocodone APAP
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Hydromet
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Hydromophan
Hydromorphone
Hydromorphone
2-3 days after use
1
Hydromorphone
Hydromorphone
Hydromorphone
2-3 days after use
1
Infumorph
Morphine
Morphine
Hydromorphone
2-3 days after use
1
Ionsys
Fentanyl
Fentanyl
Norfentanyl
Fentanyl (1 day),
Norfentanyl (up to 3 days)
1
Kadian
Morphine
Morphine
Hydromorphone
2-3 days after use
1
Klonopin
Clonazepam
Clonazepam
7-Amino-Clonazepam
1-14 days after use
1
Laudanum
Morphine
Morphine
Hydromorphone
2-3 days after use
1
Lembrol
Diazepam
Diazepam
Nordiazepam, Temazepam, Oxazepam
1-14 days after use
1
Common/Brand Name
Generic
Parent Drug
Fexmid
Cyclobenzaprine
Fioricet
Butalbital
Drug Metabolite(s)
Librax
Chlordiazepoxide
Chlordiazepoxide
Nordiazepam, Oxazepam
1-14 days after use
1
Librium
Chlordiazepoxide
Chlordiazepoxide
Nordiazepam, Oxazepam
1-14 days after use
1
Limbetrol
Amitriptyline
Amitriptyline
Noramitriptyline
5-15 days after use
2
Limbial
Oxazepam
Oxazepam
1-14 days after use
1
Lorabenz
Lorazepam
Lorazepam
1-14 days after use
1
Lorcet
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Lortab
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Madar
Nordiazepam
Nordiazepam
Oxazepam
1-14 days after use
1
Marijuana
Cannabinoids
Cannabis Sativa
THC Delta-9
2-7 days after use (up to a
month after heavy chronic use)
1
Marinol
Cannabinoids
Cannabis Sativa
THC Delta-9
2-7 days after use (up to a
month after heavy chronic use)
1
Maxidone
Methadone
Methadone
EDDP
5-10 days after use
1
Medopam
Oxazepam
Oxazepam
1-14 days after use
1
Melipramin
Imipramine
Imipramine
Desipramine
5-15 days after use
2
Methadone
Methadone
Methadone
EDDP
5-10 days after use
1
Methadose
Methadone
Methadone
EDDP
5-10 days after use
1
References:
1 - "Clinical Toxicology Testing" A Guide for Laboratory Professionals - CAP Press
2 - WIKITOX
3 - allhealthsite.com
4 - drugs.com
€ -The biological half-life or elimination half-life of a substance is the time it takes for a substance to lose half of its pharmacologic activity, as per the MeSH definition.
In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ("plasma half-life") its steady-state.
The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, active
metabolites, and receptor interactions.
The detection periods noted are general and may noy apply for everyone.
4380 Federal Drive, Suite 100
Greensboro, NC 27410
888-664-7601
www.solstas.com
Drug Metabolism Chart (4 of 5)
Common/Brand Name
Generic
Parent Drug
Drug Metabolite(s)
Detection Period (€)
Reference Source
Methadrine
Methamphetamine
Methamphetamine
Amphetamine
1-2 days after use
1
Methampex
Methamphetamine
Methamphetamine
Amphetamine
1-2 days after use
1
Mitran
Chlordiazepoxide
Chlordiazepoxide
Nordiazepam, Oxazepam
1-14 days after use
1
MS Contin
Morphine
Morphine
Hydromorphone
2-3 days after use
1
MSER
Morphine
Morphine
Hydromorphone
2-3 days after use
1
Norco
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Nordaz
Nordiazepam
Nordiazepam
Oxazepam
1-14 days after use
1
Norpramin
Desipramine
Desipramine
5-15 days after use
2
Norpress
Nortriptyline
Nortriptylene
5-15 days after use
2
Nortrilen
Nortriptyline
Nortriptylene
5-15 days after use
2
Novolaudon
Hydromorphone
Hydromorphone
2-3 days after use
1
Nucynta
Tapentadol
Tapentadol
1-2 days after use
4
Numorphan
Oxymorphone
Oxymorphone
1-4 days after use
1
Opana
Oxymorphone
Oxymorphone
1-4 days after use
1
Oramorph
Morphine
Morphine
2-3 days after use
1
Oxabenz
Oxazepam
Oxazepam
1-14 days after use
1
Oxpam
Oxazepam
Oxazepam
1-14 days after use
1
Oxycodone w/ AceTam
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Oxycodone w/ ASP
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Oxycontin
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Oxydose
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Hydromorphone
Oxyfast
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Oxyir
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Pamelor
Nortriptyline
Nortriptylene
5-15 days after use
2
Paregoric
Morphine
Morphine
Hydromorphone
2-3 days after use
1
PC Cap
Propoxyphene
Propoxyphene
Norpropoxyphene
5-10 days after use
1
PCP
Phencyclidine
Phencyclidine
10-20 days after use
1
Percocet
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Percodan
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Percolone
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Perloxx
Oxycodone
Oxycodone
Oxymorphone
1-4 days after use
1
Pertofane
Desipramine
Desipramine
5-15 days after use
2
Phenadone
Methadone
Methadone
5-10 days after use
1
Phenobarbital
Phenobarbital
Phenobarbital
2-20 days after use
1
Planum
Temazepam
Temazepam
Oxazepam
1-14 days after use
1
Polygesic
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Poxi
Chlordiazepoxide
Chlordiazepoxide
Nordiazepam, Oxazepam
1-14 days after use
1
EDDP
References:
1 - "Clinical Toxicology Testing" A Guide for Laboratory Professionals - CAP Press
2 - WIKITOX
3 - allhealthsite.com
4 - drugs.com
€ -The biological half-life or elimination half-life of a substance is the time it takes for a substance to lose half of its pharmacologic activity, as per the MeSH definition.
In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ("plasma half-life") its steady-state.
The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, active
metabolites, and receptor interactions.
The detection periods noted are general and may noy apply for everyone.
4380 Federal Drive, Suite 100
Greensboro, NC 27410
888-664-7601
www.solstas.com
Drug Metabolism Chart (5 of 5)
Common/Brand Name
Generic
Parent Drug
Drug Metabolite(s)
Detection Period (€)
Reference Source
Primalex
Oxycodone
Oxycodone
Oxymorphone
1-4 days after use
1
Pro Dorm
Lorazepam
Lorazepam
1-14 days after use
1
Pro-Pam
Diazepam
Diazepam
1-14 days after use
1
Propax
Oxazepam
Oxazepam
1-14 days after use
1
Propocet
Propoxyphene
Propoxyphene
Norpropoxyphene
5-10 hours after use
1
Propo-N
Propoxyphene
Propoxyphene
Norpropoxyphene
5-10 days after use
1
Proxagesic
Propoxyphene
Propoxyphene
Norpropoxyphene
5-10 days after use
1
Nordiazepam, Temazepam, Oxazepam
Remestan
Temazepam
Temazepam
Oxazepam
1-14 days after use
1
Reprexain
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
Restoril
Temazepam
Temazepam
Oxazepam
1-14 days after use
1
Roxanol
Morphine
Morphine
Hydromorphone
2-3 days after use
1
Roxicet
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Roxicodone
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Roxiprin
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Selegiline
Selegilene
Selegilene
Amphetamine, Methamphetamine
1-2 days after use
1
Serax
Oxazepam
Oxazepam
1-14 days after use
1
Serefax
Oxazepam
Oxazepam
1-14 days after use
1
Serenid
Oxazepam
Oxazepam
1-14 days after use
1
Seresta
Oxazepam
Oxazepam
1-14 days after use
1
Sobril
Oxazepam
Oxazepam
1-14 days after use
1
Stagesic
Hydrocodone
Hydrocodone
Hydromorphone
2-3 days after use
1
Sublimaze
Fentanyl
Fentanyl
Norfentanyl
Fentanyl (1 day),
Norfentanyl (up to 3 days)
1
Suboxone
Buprenorphine
Buprenorphine
Norbuprenorphine
2-4 days after use
1
Subutex
Buprenorphine
Buprenorphine
Norbuprenorphine
2-4 days after use
1
Symtan
Hydrocodone
Hydrocodone
Hydromorphone
2-3 days after use
1
Tazepam
Oxazepam
Oxazepam
1-14 days after use
1
Temgesic
Buprenorphine
Buprenorphine
Norbuprenorphine
2-4 days after use
1
Tofranil
Imipramine
Imipramine
Desipramine
5-15 days after use
2
Tranxene
Clorazepate
Nordiazepam
Oxazepam
1-14 days after use
1
Trepiline
Amitriptyline
Amitriptyline
Nortriptyline
5-15 days after use
2
Triavil
Amitriptyline
Amitriptyline
Nortriptyline
5-15 days after use
2
Triptyl
Amitriptyline
Amitriptyline
Nortriptyline
5-15 days after use
2
1
Tussionex
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
Tylenol 3,4,5
Codeine
Codeine
Hydrocodone, Norhydrocodone, Morphine
2-3 days after use
1
Tylox
Oxycodone
Oxycodone
Noroxycodone, Oxymorphone
1-4 days after use
1
Valium
Diazepam
Diazepam
Nordiazepam, Temazepam, Oxazepam
1-14 days after use
1
Vicodin
Hydrocodone
Hydrocodone
Norhydrocodone, Hydromorphone
2-3 days after use
1
References:
1 - "Clinical Toxicology Testing" A Guide for Laboratory Professionals - CAP Press
2 - WIKITOX
3 - allhealthsite.com
4 - drugs.com
€ -The biological half-life or elimination half-life of a substance is the time it takes for a substance to lose half of its pharmacologic activity, as per the MeSH definition.
In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ("plasma half-life") its steady-state.
The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, active
metabolites, and receptor interactions.
The detection periods noted are general and may noy apply for everyone.
4380 Federal Drive, Suite 100
Greensboro, NC 27410
888-664-7601
www.solstas.com
4380 Federal Drive Suite 100
Greenboro, NC 27410
1-888-664-7601
PATIENT NAME
TEST, MACEWINDU
REQUISITION #
REQ
OFFICE ID
443001
PATIENT ADDRESS
BILLING ACCOUNT #
ORDER #
K308150032
443001
LAB MRN
COLLECTED DATE
03/21/2013 18:39 PM
PHONE
DOB
01/22/2001
RECEIVED DATE
03/22/2013 18:39 PM
AGE
12
SEX
M
ORDERING MD
550154 Y
Prescribed Medication(s): METHADONE
LABORATORY TESTING RESULTS
Prescribed
Drugs/Metabolites
Drug Class/Drug
Amphetamine
Barbiturates
Benzodiazepines
Cannabinoids
Cocaine
Benzoylecgonine
Methadone
EDDP
Methadone
Opiates
Oxycodone
Lab
EIA
NEG
NEG
NEG
NEG
POS
Detected
Not
Detected
NON
Prescribed
Illicit
Drugs
Detected
Detected
POS
POS
LC/MS/MS (ng/mL)
Analytes
Tested &
Not
Detected
Quant
500
POS
POS
POS
800
800
NEG
NEG
Cutoff
Level
500
200
200
50
150
100
300
100
100
300
100
Lab
1
1
1
1
1
2
1
2
2
1
1
Remarks
SPECIMEN VALIDITY RESULTS
Ref Range
Creatinine, Urine
pH, Initial
Result
5.0
7.3
Ref Range
Nitrites, Initial
Result
122.0
**End of Report**
Remarks:
Clinician Comments:
Performing Laboratory Information
1
2
DLI - Doctors Laboratory, Inc. 2906 Julia Drive Valdosta GA 31602
SLN - Solstas Lab Partners 4380 Federal Drive, Suite 100 Greensboro NC 27410
Printed on: 03/25/2013 12:05 PM
** This patient result report contains confidential medical information. If you received this report in error, please contact 888-664-7601 **
pg. 1

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