Solstas PMP FolderR9-OUT
Transcription
Solstas PMP FolderR9-OUT
Why Monitor Prescription Drugs? What is the Issue? In a period of nine months, a tiny Kentucky county of fewer than 12,000 people sees a 53-year-old mother, her 35-year-old son, and seven others die by overdosing on pain medications obtained from pain clinics in Florida.1 In Utah, a 13-year-old fatally overdoses on oxycodone pills taken from a friend’s grandmother. A 20-year-old Boston man dies from an overdose of methadone, only a year after his friend also died from a prescription drug overdose.2 These events are not uncommon. Drug overdose death rates in the United States have more than tripled since 1990 and have never been higher. In 2008, more than 36,000 people died from drug overdoses, and most of these deaths were caused by prescription drugs.3 When a physician is about to prescribe a potentially addictive or mind altering drug, whether it is a central nervous system (CNS) depressant or stimulant, is it valuable to know what else the patient has not told you? Here are some interesting points to consider.4 • Should a pain reliever be prescribed without a complete picture of the patient’s health history, including knowledge of the potential presence of other prescription drugs? • Do patients always tell you the truth about what antibiotics and other drugs they are taking? • Do patients always tell you the truth about their alcohol consumption? • Do patients always tell you the truth about any possible drugs they take that might give them a “good feeling”? What are the consequences of patients giving you incomplete information and you never realizing it? Patients frequently are not willing to share some practices or behaviors with their physicians. The physician needs to perform some investigative work to identify potentially unhealthy practices. What happens when a patient is using one or more CNS depressants and it is not identified by testing? Here are some facts to consider: • There were nearly 2.1 million Emergency Room (ER) visits in 2009 for misuse or abuse of drugs.5 • Misuse of pharmaceuticals was involved in 1.2 million ER visits in 2009.5 • In 2009, nearly 200,000 medical emergencies resulting in ER visits were for drug-related suicide attempts.6 This is a list of CNS depressants that may be present with the drugs routinely prescribed. Are you ignoring Oxycodone, Hydrocodone, Fentanyl, Carisoprodol, Meperidine, Ambien, Buprenorphine, ETG (4-5 day alcohol biomarker), Tramadol, Nucynta? What are the consequences of not knowing? A number of charts and graphs showing the statistics of drug overdoses and abuse are found in the subsequent pages. Please contact your Solstas representative with further questions or inquiries. References: 1. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. (2012). Policy Impact: Prescription Painkiller Overdoses. Retrieved from http://www.cdc.gov/homeandrecreationalsafety/rxbrief. 2. O’Brien, K. Man fights what son could not. Boston Globe. (2008). Retrieved from http://www.boston.com/news/local/articles/2008/01/12/man_fights_what_son_could_not/?page=1. 3. Centers for Disease Control and Prevention. Vital Signs: Overdoses of Prescription Opioid Pain Relievers—United States, 1999-2008. MMWR 2011;60:1-6. Retrieved from http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6043a4.htm. 4. Reddy, S. ‘I Don’t Smoke, Doc,’ and Other Patient Lies. The Wall Street Journal. (2013). Retrieved from http://online.wsj.com/article/SB10001424127887323478004578306510461212692.html#articleTabs%3Darticle. 5. Substance Abuse and Mental Health Services Administration, Drug Abuse Warning Network, 2009: The DAWN Report: Highlights of the 2009 Drug Abuse Warning Network (DAWN) Findings on Drug-Related Emergency Department Visits. Retrieved from http://www.oas.samhsa.gov/2k10/DAWN034/EDHighlights.htm. 6. Substance Abuse and Mental Health Services Administration, Drug Abuse Warning Network, 2009: National Estimates of Drug-Related Emergency Department Visits. HHS Publication No. (SMA) 11-4659, DAWN Series D-35. Rockville, MD: Substance Abuse and Mental Health Services Administration, 2011. 4380 Federal Drive, Suite 100 Greensboro, NC 27410 888-664-7601 www.solstas.com 4380 Federal Drive, Suite 100 Amps Amps Amps Amps Amps Prescription Abuse Monitoring (17 Panel) Prescription Abuse Monitoring (18 Panel) Prescription Abuse Monitoring (19 Panel) 66079 66080 66081 66082 66076 Prescription Abuse Monitoring (16 Panel) 66075 66078 Prescription Abuse Monitoring (12 Panel) 66074 Amps Amps Prescription Abuse Monitoring (11 Panel) 66073 Prescription Abuse Monitoring (15 Panel) Amps Prescription Abuse Monitoring (10 Panel) 66072 66077 Amps Prescription Abuse Monitoring (9 Panel) 66071 Amps Amps Prescription Abuse Monitoring (8 Panel) 66038 Prescription Abuse Monitoring (14 Panel) Amps Prescription Abuse Monitoring (7 Panel) 66089 Prescription Abuse Monitoring (13 Panel) Amps Prescription Abuse Monitoring (6 Panel) 66037 Amps Description Prescription Monitoring Profile (5 Panel) Order Code Greensboro, NC 27410 888-664-7601 Barbs Barbs Barbs Barbs Barbs Barbs Barbs Barbs Barbs Barbs Barbs Barbs Barbs Barbs Benz Benz Benz Benz Benz Benz Benz Benz Benz Benz Benz Benz Benz Benz Benz THC THC THC THC THC THC THC THC THC THC THC THC THC THC Cocaine Cocaine Cocaine Cocaine Cocaine Cocaine Cocaine Cocaine Cocaine Cocaine Cocaine Cocaine Cocaine Methadone Opiates Methadone Opiates Methadone Opiates Methadone Opiates Methadone Opiates Methadone Opiates Methadone Opiates Methadone Opiates Methadone Opiates Methadone Opiates Methadone Opiates Methadone Opiates Methadone Opiates Methadone Opiates Oxy Oxy Oxy Oxy Oxy Oxy Oxy Oxy Oxy Oxy Oxy Oxy Oxy Oxy Cocaine Methadone Opiates Oxy Poxy Poxy Poxy Poxy Poxy Poxy Poxy Poxy Poxy Poxy Poxy Poxy Bup Bup Bup Bup Bup Bup Bup Bup Bup Bup Bup Tram Tram Tram Tram Tram Tram Tram Tram Tram Tram Tram Mepr Mepr Mepr Mepr Mepr Mepr Mepr Mepr Mepr Mepr Fty Fty Fty Fty Fty Fty Fty Fty Fty Soma Soma Soma Soma Soma Soma Soma Soma Zol Zol Zol Zol Zol Zol Zol Tap Tap Tap Tap Tap Tap XTC XTC XTC XTC Pcp Pcp Pcp Lude Lude PMP Panels www.solstas.com Drug Screen Cutoffs ELISA Screening Cut Off GC/MS or LC/MS/MS Quantitation Cut Off 500 ng/ml 100 ng/ml 200 ng/ml 150 ng/ml 200 ng/ml 100 ng/ml Cannabinoid metabolite (marijuana/THC) Cocaine (as benzoylecon) 50 ng/ml 150 ng/ml 15 ng/ml 100 ng/ml Fentanyl Meperidine/metabolite 2 ng/ml 200 ng/ml 10 ng/ml 100 ng/ml Methadone/Metabolite (EDDP) 300 ng/ml 100 ng/ml Methaqualone 300 ng/ml 150 ng/ml Opiates (Codeine, morphine, hydrocodone, hydromorphene) 300 ng/ml 100 ng/ml Oxycodone Phencyclidine 100 ng/ml 25 ng/ml 100 ng/ml 25 ng/ml Propoxyphene 300 ng/ml 100 ng/ml Tramadol 200 ng/ml 100 ng/ml Ecstacy (MDA,MDMA,MDEA) 500 ng/ml 100 ng/ml Heroin (6-am) Ambien (Zolpidem) 10 ng/ml 20 ng/ml 10 ng/ml 100 ng/ml Tapentadol (NUCYNTA) 200 ng/ml Carisoprodol (Meprobamate, OMA) 100 ng/ml 100 ng/ml Buprenorphine 10 ng/ml 10 ng/ml Ethanol ETG(Alcohol Metabolite) .04 gms% 500 ng/ml .04 gms% 500 ng/ml SPICE 5 ng/ml * 1 ng/ml Precription Monitoring Amphetamine (amphetamine, methamphetamines) Barbiturate (amobarbital, butabarbital, phenobarbital, pentobarbital, secobarbital) Benzodiazepines/metabolites (alprazolam metabolite, flurazepam metabolite, nordiazepam, oxazepam, temazepam, triazolam metabolite) Specimen Validity Testing Profile Creatinine > 20 mg/dl PH 4.5-9.0 Specific gravity General Oxidants <1.003 >200 * Screen by LC/MS/MS 4380 Federal Drive, Suite 100 Greensboro, NC 27410 888-664-7601 www.solstas.com Drug Metabolism Chart (1 of 5) Common/Brand Name Generic Parent Drug Drug Metabolite(s) Detection Period (€) Reference Source 6-AM Heroin Diacetylmorphine 6-AM 2-4 hours after use 1 AceTam w/ Codeine Codeine Codeine Hydrocodone, Norhydrocodone, Morphine 2-3 days after use 1 Actiq Fentanyl Fentanyl Norfentanyl Fentanyl (1 day), Norfentanyl (up to 3 days) 1 ADAM MDMA Amphetamine 1-2 days after use 1 Adderall Amphetamine Amphetamine 1-2 days after use 1 Adepril Amitriptyline Amitriptyline Nortriptyline 5-15 days after use 2 Alcohol Ethyl Alcohol Ethyl Alcohol ETG 4 days after use 3 Alepam Oxazepam Oxazepam 1-14 days after use 1 Allegron Nortriptyline Nortriptylene 5-15 days after use 2 Alupram Diazepam Diazepam Nordiazepam, Temazepam, Oxazepam 1-14 days after use 1 Amidon Methadone Methadone EDDP 5-10 days after use 1 Amitril Amitriptyline Amitriptyline Nortriptyline 5-15 days after use 2 Amrix Cyclobenzaprine Cyclobenzaprine 5-15 days after use 2 Anafranil Clomipramine Clomipramine 5-15 days after use 2 Anexsia Hydrocodone Hydrocodone 2-3 days after use 1 Angel Dust Phencyclidine Phencyclidine 10-20 days after use 1 Ansiolin Diazepam Diazepam Nordiazepam, Temazepam, Oxazepam 1-14 days after use 1 Antideprine Imipramine Imipramine Desipramine 5-15 days after use 2 Aspirin w/ Codeine Codeine Codeine Hydrocodone, Morphine 2-3 days after use 1 Astramorph Morphine Morphine Hydromorphone 2-3 days after use 1 Atensine Diazepam Diazepam Nordiazepam, Temazepam, Oxazepam 1-14 days after use 1 Norhydrocodone, Hydromorphone Ativan Lorazepam Lorazepam 1-14 days after use 1 Aventyl Nortriptyline Nortriptylene 5-15 days after use 2 Avinza Morphine Morphine Hydromorphone 2-3 days after use 1 Balacet Propoxyphene Propoxyphene Norpropoxyphene 5-10 days after use 1 Benzadrine Amphetamine Amphetamine 1-2 days after use 1 Benzphetaime Methamphetamine Methamphetamine Amphetamine 1-2 days after use 1 Buprenex Buprenorphine Buprenorphine Norbuprenorphine 2-4 days after use 1 Buprenorphine Buprenorphine Buprenorphine Norbuprenorphine 2-4 days after use 1 Butalbital Butalbital Butalbital 2-20 days after use 1 Butrans Buprenorphine Buprenorphine Norbuprenorphine 2-4 days after use 1 Carisoma Carisoprodol Carisoprodol Meprobamate 2-3 days after use 4 Centrex Prazepam Nordiazepam Oxazepam 1-14 days after use 1 Clonopin Clonazepam Clonazepam 7-Amino-Clonazepam 1-14 days after use 1 Cocaine Cocaine Cocaine Benzoylecgonine 2-5 days after use 1 Codal-DH Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 References: 1 - "Clinical Toxicology Testing" A Guide for Laboratory Professionals - CAP Press 2 - WIKITOX 3 - allhealthsite.com 4 - drugs.com € -The biological half-life or elimination half-life of a substance is the time it takes for a substance to lose half of its pharmacologic activity, as per the MeSH definition. In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ("plasma half-life") its steady-state. The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, active metabolites, and receptor interactions. The detection periods noted are general and may noy apply for everyone. 4380 Federal Drive, Suite 100 Greensboro, NC 27410 888-664-7601 www.solstas.com Drug Metabolism Chart (2 of 5) Common/Brand Name Generic Parent Drug Drug Metabolite(s) Detection Period (€) Reference Source Codclear-DH Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Codeine Cough Syrup Codeine Codeine Hydrocodone, Norhydrocodone, Morphine 2-3 days after use 1 Codimal-DH Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Co-Gesic Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Combunox Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Contin Morphine Morphine Hydromorphone 2-3 days after use 1 Conzip Tramadol Tramadol 2-3 days after use 4 Cyndal-HD Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Cytuss-HC Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Darvocet Propoxyphene Propoxyphene Norpropoxyphene 5-10 days after use 1 Darvon Propoxyphene Propoxyphene Norpropoxyphene 5-10 days after use 1 Demerol Meperidine Meperidine Normeperidine 1-2 days after use 4 Deprenyl Selegilene Selegilene Amphetamine, Methamphetamine 1-2 days after use 1 Deprimin Imipramine Imipramine Desipramine 5-15 days after use 2 Deprinol Imipramine Imipramine Desipramine 5-15 days after use 2 Depsonil Imipramine Imipramine Desipramine 5-15 days after use 2 Desoxyn Methamphetamine Methamphetamine Amphetamine 1-2 days after use 1 Destim Methamphetamine Methamphetamine Amphetamine 1-2 days after use 1 Detussin Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Dexedrine Amphetamine Amphetamine 1-2 days after use 1 Dextrostat Amphetamine Amphetamine 1-2 days after use 1 Diastat Diazepam Diazepam Nordiazepam, Temazepam, Oxazepam 1-14 days after use 1 Didrex Benzphetamine Benzphetamine Amphetamine, Methamphetamine 1-2 days after use 1 Dilaudid Hydromorphone Hydromorphone 2-3 days after use 1 Dipam Diazepam Diazepam Nordiazepam, Temazepam, Oxazepam 1-14 days after use 1 Emprin w/ Codeine Codeine Codeine Hydrocodone, Norhydrocodone, Morphine 2-3 days after use 1 Endal-HC Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Endep Amitriptyline Amitriptyline Nortriptyline 5-15 days after use 2 Endocet Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Endodan Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Enovil Amitriptyline Amitriptyline Nortriptyline 5-15 days after use 2 Etrafon Amitriptyline Amitriptyline Nortriptyline 5-15 days after use 2 Exalgo Hydromorphone Hydromorphone 2-3 days after use 1 Faustan Diazepam Diazepam Nordiazepam, Temazepam, Oxazepam 1-14 days after use 1 Fentanyl Fentanyl Fentanyl Norfentanyl Fentanyl (1 day), Norfentanyl (up to 3 days) 1 Fentora Fentanyl Fentanyl Norfentanyl Fentanyl (1 day) Norfentanyl (up to 3 days) 1 References: 1 - "Clinical Toxicology Testing" A Guide for Laboratory Professionals - CAP Press 2 - WIKITOX 3 - allhealthsite.com 4 - drugs.com € -The biological half-life or elimination half-life of a substance is the time it takes for a substance to lose half of its pharmacologic activity, as per the MeSH definition. In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ("plasma half-life") its steady-state. The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, active metabolites, and receptor interactions. The detection periods noted are general and may noy apply for everyone. 4380 Federal Drive, Suite 100 Greensboro, NC 27410 888-664-7601 www.solstas.com Drug Metabolism Chart (3 of 5) Detection Period (€) Reference Source Cyclobenzaprine 5-15 days after use 2 Butalbital 2-20 days after use 1 Fiorinal Butalbital Butalbital 2-20 days after use 1 Flexeril Cyclobenzaprine Cyclobenzaprine 5-15 days after use 2 G-Tuss Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Heroin Heroin Diacetylmorphine 6-AM 2-4 hours after use 1 Histinex-HC Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Histussin-HC Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Hycet Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Hycodan Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Hycomine Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Hydrocodone APAP Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Hydromet Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Hydromophan Hydromorphone Hydromorphone 2-3 days after use 1 Hydromorphone Hydromorphone Hydromorphone 2-3 days after use 1 Infumorph Morphine Morphine Hydromorphone 2-3 days after use 1 Ionsys Fentanyl Fentanyl Norfentanyl Fentanyl (1 day), Norfentanyl (up to 3 days) 1 Kadian Morphine Morphine Hydromorphone 2-3 days after use 1 Klonopin Clonazepam Clonazepam 7-Amino-Clonazepam 1-14 days after use 1 Laudanum Morphine Morphine Hydromorphone 2-3 days after use 1 Lembrol Diazepam Diazepam Nordiazepam, Temazepam, Oxazepam 1-14 days after use 1 Common/Brand Name Generic Parent Drug Fexmid Cyclobenzaprine Fioricet Butalbital Drug Metabolite(s) Librax Chlordiazepoxide Chlordiazepoxide Nordiazepam, Oxazepam 1-14 days after use 1 Librium Chlordiazepoxide Chlordiazepoxide Nordiazepam, Oxazepam 1-14 days after use 1 Limbetrol Amitriptyline Amitriptyline Noramitriptyline 5-15 days after use 2 Limbial Oxazepam Oxazepam 1-14 days after use 1 Lorabenz Lorazepam Lorazepam 1-14 days after use 1 Lorcet Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Lortab Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Madar Nordiazepam Nordiazepam Oxazepam 1-14 days after use 1 Marijuana Cannabinoids Cannabis Sativa THC Delta-9 2-7 days after use (up to a month after heavy chronic use) 1 Marinol Cannabinoids Cannabis Sativa THC Delta-9 2-7 days after use (up to a month after heavy chronic use) 1 Maxidone Methadone Methadone EDDP 5-10 days after use 1 Medopam Oxazepam Oxazepam 1-14 days after use 1 Melipramin Imipramine Imipramine Desipramine 5-15 days after use 2 Methadone Methadone Methadone EDDP 5-10 days after use 1 Methadose Methadone Methadone EDDP 5-10 days after use 1 References: 1 - "Clinical Toxicology Testing" A Guide for Laboratory Professionals - CAP Press 2 - WIKITOX 3 - allhealthsite.com 4 - drugs.com € -The biological half-life or elimination half-life of a substance is the time it takes for a substance to lose half of its pharmacologic activity, as per the MeSH definition. In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ("plasma half-life") its steady-state. The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, active metabolites, and receptor interactions. The detection periods noted are general and may noy apply for everyone. 4380 Federal Drive, Suite 100 Greensboro, NC 27410 888-664-7601 www.solstas.com Drug Metabolism Chart (4 of 5) Common/Brand Name Generic Parent Drug Drug Metabolite(s) Detection Period (€) Reference Source Methadrine Methamphetamine Methamphetamine Amphetamine 1-2 days after use 1 Methampex Methamphetamine Methamphetamine Amphetamine 1-2 days after use 1 Mitran Chlordiazepoxide Chlordiazepoxide Nordiazepam, Oxazepam 1-14 days after use 1 MS Contin Morphine Morphine Hydromorphone 2-3 days after use 1 MSER Morphine Morphine Hydromorphone 2-3 days after use 1 Norco Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Nordaz Nordiazepam Nordiazepam Oxazepam 1-14 days after use 1 Norpramin Desipramine Desipramine 5-15 days after use 2 Norpress Nortriptyline Nortriptylene 5-15 days after use 2 Nortrilen Nortriptyline Nortriptylene 5-15 days after use 2 Novolaudon Hydromorphone Hydromorphone 2-3 days after use 1 Nucynta Tapentadol Tapentadol 1-2 days after use 4 Numorphan Oxymorphone Oxymorphone 1-4 days after use 1 Opana Oxymorphone Oxymorphone 1-4 days after use 1 Oramorph Morphine Morphine 2-3 days after use 1 Oxabenz Oxazepam Oxazepam 1-14 days after use 1 Oxpam Oxazepam Oxazepam 1-14 days after use 1 Oxycodone w/ AceTam Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Oxycodone w/ ASP Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Oxycontin Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Oxydose Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Hydromorphone Oxyfast Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Oxyir Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Pamelor Nortriptyline Nortriptylene 5-15 days after use 2 Paregoric Morphine Morphine Hydromorphone 2-3 days after use 1 PC Cap Propoxyphene Propoxyphene Norpropoxyphene 5-10 days after use 1 PCP Phencyclidine Phencyclidine 10-20 days after use 1 Percocet Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Percodan Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Percolone Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Perloxx Oxycodone Oxycodone Oxymorphone 1-4 days after use 1 Pertofane Desipramine Desipramine 5-15 days after use 2 Phenadone Methadone Methadone 5-10 days after use 1 Phenobarbital Phenobarbital Phenobarbital 2-20 days after use 1 Planum Temazepam Temazepam Oxazepam 1-14 days after use 1 Polygesic Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Poxi Chlordiazepoxide Chlordiazepoxide Nordiazepam, Oxazepam 1-14 days after use 1 EDDP References: 1 - "Clinical Toxicology Testing" A Guide for Laboratory Professionals - CAP Press 2 - WIKITOX 3 - allhealthsite.com 4 - drugs.com € -The biological half-life or elimination half-life of a substance is the time it takes for a substance to lose half of its pharmacologic activity, as per the MeSH definition. In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ("plasma half-life") its steady-state. The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, active metabolites, and receptor interactions. The detection periods noted are general and may noy apply for everyone. 4380 Federal Drive, Suite 100 Greensboro, NC 27410 888-664-7601 www.solstas.com Drug Metabolism Chart (5 of 5) Common/Brand Name Generic Parent Drug Drug Metabolite(s) Detection Period (€) Reference Source Primalex Oxycodone Oxycodone Oxymorphone 1-4 days after use 1 Pro Dorm Lorazepam Lorazepam 1-14 days after use 1 Pro-Pam Diazepam Diazepam 1-14 days after use 1 Propax Oxazepam Oxazepam 1-14 days after use 1 Propocet Propoxyphene Propoxyphene Norpropoxyphene 5-10 hours after use 1 Propo-N Propoxyphene Propoxyphene Norpropoxyphene 5-10 days after use 1 Proxagesic Propoxyphene Propoxyphene Norpropoxyphene 5-10 days after use 1 Nordiazepam, Temazepam, Oxazepam Remestan Temazepam Temazepam Oxazepam 1-14 days after use 1 Reprexain Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 Restoril Temazepam Temazepam Oxazepam 1-14 days after use 1 Roxanol Morphine Morphine Hydromorphone 2-3 days after use 1 Roxicet Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Roxicodone Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Roxiprin Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Selegiline Selegilene Selegilene Amphetamine, Methamphetamine 1-2 days after use 1 Serax Oxazepam Oxazepam 1-14 days after use 1 Serefax Oxazepam Oxazepam 1-14 days after use 1 Serenid Oxazepam Oxazepam 1-14 days after use 1 Seresta Oxazepam Oxazepam 1-14 days after use 1 Sobril Oxazepam Oxazepam 1-14 days after use 1 Stagesic Hydrocodone Hydrocodone Hydromorphone 2-3 days after use 1 Sublimaze Fentanyl Fentanyl Norfentanyl Fentanyl (1 day), Norfentanyl (up to 3 days) 1 Suboxone Buprenorphine Buprenorphine Norbuprenorphine 2-4 days after use 1 Subutex Buprenorphine Buprenorphine Norbuprenorphine 2-4 days after use 1 Symtan Hydrocodone Hydrocodone Hydromorphone 2-3 days after use 1 Tazepam Oxazepam Oxazepam 1-14 days after use 1 Temgesic Buprenorphine Buprenorphine Norbuprenorphine 2-4 days after use 1 Tofranil Imipramine Imipramine Desipramine 5-15 days after use 2 Tranxene Clorazepate Nordiazepam Oxazepam 1-14 days after use 1 Trepiline Amitriptyline Amitriptyline Nortriptyline 5-15 days after use 2 Triavil Amitriptyline Amitriptyline Nortriptyline 5-15 days after use 2 Triptyl Amitriptyline Amitriptyline Nortriptyline 5-15 days after use 2 1 Tussionex Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use Tylenol 3,4,5 Codeine Codeine Hydrocodone, Norhydrocodone, Morphine 2-3 days after use 1 Tylox Oxycodone Oxycodone Noroxycodone, Oxymorphone 1-4 days after use 1 Valium Diazepam Diazepam Nordiazepam, Temazepam, Oxazepam 1-14 days after use 1 Vicodin Hydrocodone Hydrocodone Norhydrocodone, Hydromorphone 2-3 days after use 1 References: 1 - "Clinical Toxicology Testing" A Guide for Laboratory Professionals - CAP Press 2 - WIKITOX 3 - allhealthsite.com 4 - drugs.com € -The biological half-life or elimination half-life of a substance is the time it takes for a substance to lose half of its pharmacologic activity, as per the MeSH definition. In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ("plasma half-life") its steady-state. The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, active metabolites, and receptor interactions. The detection periods noted are general and may noy apply for everyone. 4380 Federal Drive, Suite 100 Greensboro, NC 27410 888-664-7601 www.solstas.com 4380 Federal Drive Suite 100 Greenboro, NC 27410 1-888-664-7601 PATIENT NAME TEST, MACEWINDU REQUISITION # REQ OFFICE ID 443001 PATIENT ADDRESS BILLING ACCOUNT # ORDER # K308150032 443001 LAB MRN COLLECTED DATE 03/21/2013 18:39 PM PHONE DOB 01/22/2001 RECEIVED DATE 03/22/2013 18:39 PM AGE 12 SEX M ORDERING MD 550154 Y Prescribed Medication(s): METHADONE LABORATORY TESTING RESULTS Prescribed Drugs/Metabolites Drug Class/Drug Amphetamine Barbiturates Benzodiazepines Cannabinoids Cocaine Benzoylecgonine Methadone EDDP Methadone Opiates Oxycodone Lab EIA NEG NEG NEG NEG POS Detected Not Detected NON Prescribed Illicit Drugs Detected Detected POS POS LC/MS/MS (ng/mL) Analytes Tested & Not Detected Quant 500 POS POS POS 800 800 NEG NEG Cutoff Level 500 200 200 50 150 100 300 100 100 300 100 Lab 1 1 1 1 1 2 1 2 2 1 1 Remarks SPECIMEN VALIDITY RESULTS Ref Range Creatinine, Urine pH, Initial Result 5.0 7.3 Ref Range Nitrites, Initial Result 122.0 **End of Report** Remarks: Clinician Comments: Performing Laboratory Information 1 2 DLI - Doctors Laboratory, Inc. 2906 Julia Drive Valdosta GA 31602 SLN - Solstas Lab Partners 4380 Federal Drive, Suite 100 Greensboro NC 27410 Printed on: 03/25/2013 12:05 PM ** This patient result report contains confidential medical information. If you received this report in error, please contact 888-664-7601 ** pg. 1