Run Bins Run Details Motif Z- score Known Match

Transcription

Run
protein_40_YPR119W
protein_40_YBR160W
yeast-256_GO-0016462
yeast-238_GO-0017111
yeast-335_GO-0016772
yeast-335_GO-0016772
yeast-335_GO-0016772
protein_40_YAR019C
protein_40_YDL153C
protein_40_YNL272C
yeast-1974_GO-0005634
yeast-685_GO-0016740
protein_40_YAR019C
yeast-685_GO-0016740
yeast-238_GO-0017111
protein_40_YNL272C
yeast-335_GO-0016772
yeast-335_GO-0016772
protein_40_YDL153C
yeast-1074_GO-0044428
protein_40_YNL186W
yeast-335_GO-0016772
yeast-335_GO-0016772
ubiquitin_peng2003
yeast-1433_GO-0006139
protein_40_YNL186W
protein_40_YJR059W
protein_40_YDL153C
protein_40_YNL186W
matsuyama_nucleolus
yeast-335_GO-0016772
yeast-661_GO-0050789
yeast-335_GO-0016772
yeast-335_GO-0016772
protein_40_YDL153C
yeast-593_GO-0031981
yeast-648_GO-0050791
protein_40_YAR019C
protein_40_YDL153C
protein_40_YGL105W
yeast-256_GO-0016462
protein_40_YGL245W
yeast-1074_GO-0044428
yeast-752_GO-0016787
yeast-335_GO-0016772
yeast-1547_GO-0043283
protein_40_YAR019C
protein_40_YNL272C
protein_40_YAR019C
protein_40_YJL164C
protein_40_YNL272C
yeast-685_GO-0016740
protein_40_YAR019C
yeast-462_GO-0019222
matsuyama_ER
yeast-299_GO-0005730
protein_40_YFR024C-A
protein_40_YNL272C
protein_40_YNL186W
yeast-335_GO-0016772
protein_40_YGL105W
protein_40_YPL093W
yeast-436_GO-0031323
yeast-1062_GO-0016020
protein_40_YAR019C
yeast-685_GO-0016740
yeast-470_GO-0006259
yeast-335_GO-0016772
protein_40_YAR019C
yeast-685_GO-0016740
yeast-462_GO-0019222
yeast-335_GO-0016772
yeast-255_GO-0007028
yeast-255_GO-0042254
yeast-376_GO-0019219
yeast-217_GO-0007046
protein_40_YAR019C
protein_40_YKL014C
oshea_nucleolus
matsuyama_ER
protein_40_YPR119W
protein_40_YNL186W
protein_40_YIL035C
yeast-335_GO-0016772
yeast-685_GO-0016740
yeast-661_GO-0050789
matsuyama_ER
protein_40_YBR160W
matsuyama_ER
protein_40_YBR160W
yeast-341_GO-0045449
yeast-238_GO-0017111
protein_40_YDL153C
yeast-335_GO-0016772
yeast-335_GO-0016772
yeast-504_GO-0006350
yeast-312_GO-0006414
yeast-685_GO-0016740
yeast-1939_GO-0003824
protein_40_YOR061W
yeast-1115_GO-0006996
yeast-256_GO-0016462
protein_40_YLL008W
yeast-335_GO-0016772
yeast-685_GO-0016740
protein_40_YER125W
protein_40_YBL007C
oshea_spindle_pole
yeast-1216_GO-0009058
yeast-942_GO-0043232
yeast-942_GO-0043228
yeast-376_GO-0019219
yeast-248_GO-0016072
yeast-1062_GO-0016020
protein_40_YGL245W
protein_40_YOR206W
protein_40_YPR119W
yeast-238_GO-0017111
yeast-200_GO-0006519
protein_40_YMR290C
protein_40_YOR063W
protein_40_YGL120C
matsuyama_periphery
oshea_bud_neck
yeast-299_GO-0005730
protein_40_YAR019C
protein_40_YDL153C
protein_40_YPL093W
yeast-685_GO-0016740
yeast-222_GO-0009308
protein_40_YMR047C
Bins
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Mutual
Robust
information
ness
(MI)
0.055
10
CDC28: Catalytic subunit of the main cell cycle cyclin-dependent
SP.[RK]
kinase (CDK); alternately
295 SP.[RK]
associates with G1CDK
cyclins
kinase
(CLNs)
substrate
and G2/Mmotif
cyclins (CLBs)
Y which direct
Pkinase
the CDK to specific
1.E-04
substrates-3.5
cell cycle (1e-17)
0.053
10
pyrophosphatase activity
G.GK[TS]
227 SG.G
Glycosaminoglycan attachment site
ABC_tran
1.E-19
4.5
nucleoside-triphosphatase activity (1e-11)
0.047
10
nucleoside-triphosphatase activity
G.GK[ST]
221 SG.G
AAA
1.E-18
5.5
0.048
10
transferase activity, transferring phosphorus-containing
[KVY][LIY].DFG
groups
205
Pkinase
1.E-85
8.1
protein kinase activity (1e-85)
0.046
10
transferase activity, transferring phosphorus-containing groups
H.D[LIC]K
197
Pkinase
1.E-09
8.5
0.044
10
H[RCW]D[ILMV]
groups
168
Pkinase
1.E-90
8.3
Y
0.038
10
CDC15: Protein kinase of the Mitotic Exit Network that
H[RQS]D[ILM]K
is localized to the spindle pole
167bodies at late anaphase; promotes mitotic exit by directly switching
Y
on thePkinase
kinase activity of Dbf2p
1.E-29
5.4
Y
0.018
10
SAS10: Component of the small (ribosomal) subunitH[RCS]D[ILV]K
(SSU) processosome required
165
for pre-18S rRNa processing; essential nucleolar protein that, when overproduced,
Pkinase
disrupts silencing
1.E-27
4.8
0.017
10
SEC2: Guanyl-nucleotide exchange factor for the small
[HVY]RD[LIM]K
G-protein Sec4p, located 154
on cytoplasmic vesicles; essential for post-Golgi vesicle transport
Pkinase
1.E-30
5
Y
0.017
10
nucleus
K[KRP].K
154 K[KR].[KR]
Nuclear localization motif
Zn_clus
1.E-07
6.4
nuclear lumen (1e-10)
0.032
10
transferase activity
H[RCG]D[ILMV]K
151
Pkinase
1.E-09
8.7
0.033
10
[KLY][ILY].DFG
148bodies at late anaphase; promotes mitotic exit by directly switching
Y
on thePkinase
1.E-28
4.9
0.015
10
[KVY][LIV].DFG
148
Pkinase
1.E-89
8
0.033
10
[WFL]D..GQ[EDP]
136 D..G
motif that binds phosphate in GDP and GTP binding
Ras proteins1.E-37
2.7
GTPase activity (1e-38)
0.020
10
[KVE][ILV].DFG
G-protein Sec4p, located 136
on cytoplasmic vesicles; essential for post-Golgi vesicle transport
Pkinase
1.E-28
4.5
0.014
10
transferase activity, transferring phosphorus-containing Y.[ASG]PE
groups
132 E.Y.[QSG]
Protease TEVProtease TEV
Pkinase
1.E-89
7.4
Y
0.030
10
D[ILMV]W[SAQ]
groups
132 PWDLW
LIG_Clathr_ClatBox_2
Pkinase
1.E-85
8
Y
0.029
10
SAS10: Component of the small (ribosomal) subunitDFG[LSF][ACV]
131
Pkinase
disrupts silencing
1.E-23
4.4
0.014
10
nuclear part
DE[EDK][ED]
131 YDE[PDV]
SH2 ligand for Nck1 and Nck2 (Tyr
Y must be phosphorylated)
Y
0.026
10
UBP10: Ubiquitin-specific protease that deubiquitinates
[RSL]D[LIV]KP
ubiquitin-protein moieties;129
may regulate
DALDL
silencing by acting
14-3-3
onbinding
Sir4p; involved
motif in
in ExoS
posttranscriptionally regulating
Pkinase
Gap1p and 1.E-28
possibly other transporters;
3.9
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-25)
0.014
10
[ILMV]K..N[ILV]L
groups
129
Pkinase
1.E-83
7.9
Y
0.029
10
KP.N[IVL][LMF]
groups
128
Pkinase
1.E-72
6.6
0.028
10
ubiquitin_peng2003
L..[LDS]A
125
Y
IBN_N
1.E-05
-0.4
Golgi apparatus (1e-08)
0.021
10
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
K[KRH].K
124 K[KR].[KR]
Helicase_C
1.E-06
-1.9
DNA metabolism (1e-11)
Y
0.027
10
KP.N[LIV][LM]
may regulate silencing by acting on Sir4p; involved in posttranscriptionally
Y
regulating
Pkinase
Gap1p and 1.E-25
3.8
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-22)
Y
0.012
10
PTK2: Putative serine/threonine protein kinase involvedRR.[SHP]
in regulation of ion transport
122across
[KR]R
plasma membrane;
CLV_PCSK_KEX2_1
enhances spermine uptake
phosphotransferase activity, alcohol group as acceptor (0.01)
0.022
10
SAS10: Component of the small (ribosomal) subunitK[LIV].D[FW]G
121
Pkinase
disrupts silencing
1.E-23
4.2
Y
0.013
10
K..D[FWP]G
may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating
Pkinase
Gap1p and 1.E-27
4.9
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-23)
Y
0.013
10
matsuyama_nucleolus
KK.[KR][KRS]
119 K[KR].[KR]
Helicase_C
1.E-03
-1.2
nucleolus (1e-98)
0.029
10
W[SAQ].G[CVI]
groups
117
Y
Pkinase
1.E-79
7.4
Y
0.027
10
regulation of biological process
N[NSE]N[SNV]
111
Zn_clus
1.E-06
-1.1
regulation of metabolism (1e-09)
0.023
10
W[SA][LVC]G
groups
111 WA.G[SH][LF]MBOMBESIN PATTERN
Pkinase
1.E-68
7.2
Y
0.025
10
transferase activity, transferring phosphorus-containingRD[LIV][KT]
groups
111 MR[DE][IL]
TUBULIN_B_AUTOREG PATTERN
Pkinase
1.E-86
7.8
kinase activity (1e-85)
Y
0.024
10
SAS10: Component of the small (ribosomal) subunitW[SAG].G[ICV]
109
Pkinase
disrupts silencing
1.E-25
4.4
0.012
10
nuclear lumen
DE[DEK][DEI]
107 YDE[PDV]
Y must be phosphorylated)
0.022
10
regulation of physiological process
N[SNE]N[SNV]
105
Zn_clus
1.E-06
-1.1
0.022
10
W[SAG][LCI]G
104bodies at late anaphase; promotes mitotic exit by directly switching on thePkinase
1.E-26
5.1
Y
0.012
10
SAS10: Component of the small (ribosomal) subunitY[RMA][AS]PE
103
for pre-18S
SP rRNa processing;
ERK1,
essential
ERK2nucleolar
Kinase protein
substrate
that,motif
when
Y overproduced,
Pkinase
disrupts silencing
1.E-19
3.6
Y
0.012
10
ARC1: Protein that binds tRNA and methionyl- and K[ILV].[DCG]FG
glutamyl-tRNA synthetases (Mes1p
103 and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuringPkinase
their localization to1.E-20
the cytoplasm; 4.7
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-20)
Y
0.010
10
TA.Q[ERV][RED]
101
Y
Ras
1.E-30
2.5
Y
0.014
10
GUS1: Glutamyl-tRNA synthetase (GluRS), forms a[HYA]RD[ILMV]K
complex with methionyl-tRNA101
synthetase
[AG]R
(Mes1p) and Arc1p;
Protease
complex
matriptase
formation protease
increases the
sitecatalytic efficiency
Pkinase
of both tRNA1.E-29
synthetases and
5.4
ensuresprotein
their correct
kinase
localization
activity
to the
(1e-26)
cytoplasm
0.013
10
nuclear part
[KRN]KR[KSR]
99 KR
CLV_PCSK_PC1ET2_1
Bromodomain
1.E-03
-1.1
Y
0.021
10
hydrolase activity
G.GK[TSH]
99 SG.G
AAA
1.E-19
5.5
Y
0.021
10
[IVW]W..G[VCI]
groups
99 [FW]W
EH(3) EF hand domain binding motif of EPS15,
Pkinase
Class II
1.E-56
6.9
Y
0.022
10
biopolymer metabolism
K[KRN].K
98 K[KR].[KR]
Helicase_C
1.E-05
-1.8
0.020
10
GT..[WY][MRI]A
98 bodies
[ST]FCGT.[ED]Y
at late anaphase;PDK1
promotes
phosphorylation
mitotic exit by directly
motif switching on thePkinase
1.E-13
4.2
0.011
10
[KN]P.N[LIF]L
G-protein Sec4p, located on
97cytoplasmic vesicles; essential for post-Golgi vesicle transport
Pkinase
1.E-18
3.9
Y
0.011
10
CDC15: Protein kinase of the Mitotic Exit Network that is
Y.[ASF]PE
localized to the spindle pole
96 bodies
E.Y.[QSG]
at late anaphase;Protease
promotes TEVProtease
mitotic exit by directly
TEV switching on thePkinase
1.E-25
4
0.012
10
TPK1: cAMP-dependent protein kinase catalytic subunit;R[RK].S
promotes vegetative growth
96 in response
R[KER].S
to nutrients PKC
via theepsilon
Ras-cAMP
kinase
signaling
substrate
pathway;
motif
inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p
Y
0.017
10
[LIM]K..N[ILF]L
Pkinase
1.E-25
4.6
Y
0.012
10
Y.[ASQ]PE
95 E.Y.[QSG]
Pkinase
1.E-81
7.3
Y
0.021
10
[ILA]K..N[IVC]L
94 bodies at late anaphase; promotes mitotic exit by directly switching on thePkinase
1.E-20
4
0.010
10
regulation of metabolism
N[NEI]N
93
Zn_clus
1.E-09
-1.4
Y
0.020
10
matsuyama_ER
FF[TLG]
93 [FYWS][RK].GFF.R
INTEGRIN_ALPHA PATTERN
MFS_1
1.E-03
0.4
endoplasmic reticulum part (1e-31)
Y
0.023
10
nucleolus
[KVA]K..K[KRH]
92 KR
CLV_PCSK_PC1ET2_1
Helicase_C
1.E-02
-1
nucleolus (1e-11)
Y
0.019
10
LSB3: Protein containing a C-terminal SH3 domain;[PQ]P..P[PTM]R
binds Las17p, which is a homolog
92 of P..P
human Wiskott-Aldrich
SH3
Syndrome
generalprotein
ligand,involved in actin patch assembly and actin polymerization
actin cytoskeleton organization and biogenesis (1e-05)
0.010
10
W[SGA].G[CVI]
Pkinase
1.E-25
4.3
0.011
10
W[SA].G[CVI]
ubiquitin-protein moieties; 91
Pkinase
Gap1p and 1.E-25
4.4
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-25)
0.011
10
[GA][LVG].YLH
groups
91 Y[LI]
SH2 ligand for PLCgamma1 N-term.)groupPkinase
3(phospho-peptide)
1.E-24
4.5
0.015
10
ARC1: Protein that binds tRNA and methionyl- and glutamyl-tRNA
[HYE]RD[ILM]K
synthetases (Mes1p
the cytoplasm; 4.7
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-20)
Y
0.010
10
NOG1: Putative GTPase that associates with freeGR..[RKA][AGL]G
60S ribosomal subunits in the nucleolus
89 [AG]R
and is required for Protease
60S ribosomal
matriptase
subunit biogenesis;
protease site
constituent of 66S
DEAD
pre-ribosomal particles;
1.E-08 member
-1.6
of the ODN
RNA
family
helicase
of nucleolar
activity
G-proteins
(1e-07)
0.009
10
regulation of cellular metabolism
N[NEI]N
89
Zn_clus
1.E-08
-1.3
regulation of cellular metabolism (1e-26)
Y
0.020
10
membrane
L[LAF]G
89 LLG
Beta2-Integrin binding motif
Mito_carr
1.E-06
0.3
intrinsic to membrane (1e-67)
Y
0.018
10
CDC15: Protein kinase of the Mitotic Exit Network that[MRI][AM]PE
1.E-20
4.5
0.010
9
D[ILMV]W[SAQ]
89 PWDLW
Pkinase
1.E-76
7.8
Y
0.019
10
DNA metabolism
KR.[KRM]
87 KR
CLV_PCSK_PC1ET2_1
BRCT
1.E-02
-1.4
0.018
10
Y[CY]..G[DSE]L
groups
87
Pkinase
1.E-13
3
0.011
10
D[IL]..EN[VIL]
87 bodies
KEN
at late anaphase;LIG_APCC_KENbox_2
promotes mitotic exit by directly switching on thePkinase
1.E-15
3.7
Y
0.008
10
W[SAQ].G[CVI]
87
Y
Pkinase
1.E-75
7.6
Y
0.019
10
[SAQ]S..[NSP]S
86 S..[ST]
Casein Kinase I consensus phosphorylationZn_clus
site (N-term Ser1.E-09
must first be -0.9
phosphorylated)
0.017
10
G[TSN]..Y[ILMV]A
groups
86 Y[VLTFIC]
LIG_SH2_STAT5
Pkinase
1.E-34
5.3
0.017
10
cytoplasm organization and biogenesis
[KVQ]K..K[KRH]
85 KR
CLV_PCSK_PC1ET2_1
DEAD
1.E-03
-0.9
cytoplasm organization and biogenesis (1e-10)
Y
0.018
10
ribosome biogenesis and assembly
[KVQ]K..K[KRH]
85 KR
CLV_PCSK_PC1ET2_1
DEAD
1.E-03
-0.8
Y
0.018
10
regulation of nucleobase, nucleoside, nucleotide and nucleic
N[NEI]N
acid metabolism
84
Zn_clus
1.E-08
-1.4
Y
acid metabolism
0.017 (1e-24)
10
ribosome biogenesis
[KVQ]K..K[KRH]
84 KR
CLV_PCSK_PC1ET2_1
DEAD
1.E-04
-1.2
ribosome biogenesis (1e-10)
Y
0.018
10
KP[EQA]N[IVF]
84 bodies
FKPY
at late anaphase;TLA
promotes
binding
mitotic
motif
exit
inby
Brinker
directlytranscription
switching on the
factor
Pkinase
kinase
foractivity
binding
of TLA
Dbf2p
1.E-16
domain in Groucho
3.4
Y
0.009
10
URB1: Nucleolar protein required for the normal accumulation
[TEA]RE[LH]A
of 25S and 5.8S rRNAs,
84 associated
[AG]R with the 27SA2
Protease
pre-ribosomal
matriptase
particle;
protease
proposed
site
Yto be involved
DEAD
in the biogenesis1.E-06
of the 60S ribosomal
3.5 subunit
ATP-dependent RNA helicase activity (1e-07)
Y
0.009
10
oshea_nucleolus
[KAV]K..K[KRH]
84 KR
CLV_PCSK_PC1ET2_1
nucleolus (1e-76)
0.017
10
matsuyama_ER
I..[FLT]F
84 D..SII.FF
CK I delta kinase phosphorylation site (peptide screen)
Y
0.020
10
CLB2: B-type cyclin involved in cell cycle progression; activates
E.E[DKY]
Cdc28p to promote
83the transition
Y.E.E from G2 to M
Src
phase;
phosphorylation
accumulates during
site G2 and M, then targeted
PHvia a destruction
1.E-03
box motif for -1.2
ubiquitin-mediated
cell cycle
degradation
(1e-15)by the proteasome
0.015
10
[ILMV]W..G[VCI]
Pkinase
Gap1p and 1.E-23
4.4
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-23)
Y
0.009
10
CKA1: Alpha catalytic subunit of casein kinase 2, a ED..[EVK][EDQ]
Ser/Thr protein kinase with roles
82in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription
nuclearfactors
lumen
and(1e-11)
all RNA polymerases
0.015
10
[LIR]K.[EQW]N
groups
81 [VILAFP]K.E Motif recognized for modification by SUMO-1
Pkinase
1.E-58
6.2
Y
(1e-86)0.017
10
[LIM]K..N[ILV]L
81
Y
Pkinase
1.E-76
8
Y
0.018
10
Q[QHD]Q
80 GQDQTKQQI 43_KD_POSTSYNAPTIC PATTERN
zf-C2H2
1.E-04
0
0.017
10
matsuyama_ER
L..F[LFI]
80
MFS_1
1.E-03
0.9
Y
0.020
10
E.E[KDY]
79 Y.E.E
associates with G1Src
cyclins
phosphorylation
(CLNs) and G2/M
sitecyclins (CLBs) which direct
Pkinase
the CDK to specific
1.E-03
substrates 0
cell cycle (1e-19)
Y
0.014
10
matsuyama_ER
I...[LFY]F
79 L...I...[IL]
Corepressor nuclear box motif binds to nuclear
MFS_1
receptors
1.E-06
1.4
Y
0.019
10
V..[TSP]P
78 [ST]P
associates with G1LIG_WW_4LIG_WW_4
cyclins (CLNs) and G2/M cyclins (CLBs) which direct
Pkinase
the CDK to specific
1.E-05
substrates-1.7
site of polarized growth (1e-11)
Y
0.014
10
regulation of transcription
N[NEI]N
78
Zn_clus
1.E-09
-1.3
regulation of transcription (1e-23)
Y
0.016
10
TA..E[RED][FY]
78
Ras
1.E-33
2.6
Y
0.012
10
SAS10: Component of the small (ribosomal) subunit (SSU)
K[PV].N.L
processosome required
78for pre-18S rRNa processing; essential nucleolar protein that, when overproduced,
Pkinase
disrupts silencing
1.E-17
3.6
0.010
10
[ILV]G.G[SAT]F
groups
78 G[GA]G[ASC][FY]S.K[DE]
ADOMET_SYNTHETASE_2 PATTERN
Y
Pkinase
1.E-36
5.2
0.016
10
[YW][RMI].PE
groups
78 [IVL].Y[FM].P SHP2 N-terminal SH2 domain binding motifPkinase
1.E-65
6.7
Y
0.018
10
transcription
N[NTP]N[NAP]
77 PNAY
CrkII motif in C-terminal SH3 domain
Y required
Zn_clus
for Abl activation
1.E-03
-0.7
transcription (1e-10)
0.016
10
translational elongation
D[VM].F[GQ]
77
Y
Ribosomal_60s
1.E-11
1.6
translational elongation (1e-21)
Y
0.010
10
K[PTA].N[ILMV]L
77
Pkinase
1.E-62
7.3
Y
0.017
10
catalytic activity
HRD[ILMV][KIP]
77 [LIVMF]PCHR[LIVMF][LIVMF]
MGMT PATTERN
Pkinase
1.E-82
7.8
0.016
10
CKA2: Alpha' catalytic subunit of casein kinase 2, a Ser/Thr
D[EDC][ESH]D
protein kinase with roles
77in cell
DEHD
growth and proliferation;
Protease
the holoenzyme
Caspase 1also
/ICEcontains CKA1, CKB1 and CKB2, the many substrates include transcription
RNA elongation
factors and from
all RNA
RNA
polymerases
polymerase II promoter (1e-09)
0.015
10
organelle organization and biogenesis
EE[DRN][EDI]
76 EED
Ankyrin B C-terminal motif that binds internal
Helicase_C
Ankyrin repeats1.E-03
-0.7
chromosome organization and biogenesis (1e-51)
0.016
10
I[LWF]D[ETM]A
76
Ras
1.E-12
1.7
Y
0.013
10
DRS1: Nucleolar DEAD-box protein required for ribosome
KP.N[LFV][LMK]
assembly and function, 76
including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal
Pkinase
particles
1.E-15
3.4
0.008
10
[YWQ][RMI]AP
groups
76
Pkinase
1.E-46
6.4
Y
0.017
10
[ILMV]W..G[VCI]
76
Pkinase
1.E-67
7.2
Y
0.016
10
RSP5: Ubiquitin-protein ligase involved in ubiquitin-mediated
PP.Y
protein degradation; 76
functions
PP.Y
in multivesicular body
LIG_WW_1LIG_WW_1
sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain
Y
0.014
10
SLA1: Cytoskeletal protein binding protein required [PQR]PP[LRI]P
for assembly of the cortical actin
76cytoskeleton;
PPLP interacts with
LIG_WW_2LIG_WW_2
proteins regulating actin dynamicsYand proteins required for endocytosis; found in the nucleus
actin
and cell
cortical
cortex;patch
has 3 SH3
(1e-05)
domains
0.008
10
oshea_spindle_pole
L[LGP]..[SMR]LR
76
spindle (1e-13)
0.008
10
biosynthesis
N.[SNY]S
75 N.[TS]
N-linked glycosylation site
Y
Pkinase
1.E-03
-3.4
0.016
10
intracellular non-membrane-bound organelle
[KSA]K..K[KRV]
75 KR
CLV_PCSK_PC1ET2_1
DEAD
1.E-03
-2
nucleolus (1e-70)
Y
0.015
10
non-membrane-bound organelle
[KSA]K..K[KRV]
75 KR
CLV_PCSK_PC1ET2_1
DEAD
1.E-03
-2
nucleolus (1e-70)
Y
0.015
10
regulation of nucleobase, nucleoside, nucleotide and[SAP]S..[NSP]S
nucleic acid metabolism
75 S..[ST]
Casein Kinase I consensus phosphorylation
zf-C2H2
must first be -1.5
phosphorylated)
Y
acid metabolism
0.015 (1e-18)
10
rRNA metabolism
[AKV]K..K[RKH]
75 KR
CLV_PCSK_PC1ET2_1
Helicase_C
1.E-02
-1.1
rRNA metabolism (1e-09)
0.016
10
membrane
V[GFA].F
75 F.FP
LIG_MAPK_2LIG_MAPK_2
MFS_1
1.E-04
1
transporter activity (1e-45)
Y
0.015
10
GUS1: Glutamyl-tRNA synthetase (GluRS), forms aDFG[LMS][ACE]
complex with methionyl-tRNA 75
synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency
Pkinase
of both tRNA1.E-16
synthetases and
3.7
ensuresprotein
their correct
kinase
localization
activity
to the
(1e-15)
cytoplasm
Y
0.008
10
NOC2: Protein that forms a nucleolar complex with R[VAL]G[RQC]T
Mak21p that binds to 90S and 75
66S pre-ribosomes, as well as a nuclear complex with Noc3p that
Y binds to Helicase_C
66S pre-ribosomes; both
1.E-07
complexes mediate
7.8 intranuclear
RNA helicase
transportactivity
of ribosomal
(1e-08)
precursors
0.008
10
L..SPCdc28p to promote
74the transition
SP
from G2 to M
ERK1,
phase;ERK2
accumulates
Kinaseduring
substrate
G2 and
motif
M, then targeted
Pkinase
via a destruction
1.E-03
box motif for -1.4
ubiquitin-mediated
bud neck
degradation
0.013
10
[LFI][YHD].PPG
74
AAA
1.E-18
4.4
ATPase activity (1e-15)
0.009
10
amino acid and derivative metabolism
KM[SW][KA]S
74
amino acid activation (1e-16)
Y
0.009
10
HAS1: ATP-dependent RNA helicase; localizes to both
K[KVM]..K[KRE]
the nuclear periphery and nucleolus;
74 KRhighly enriched inCLV_PCSK_PC1ET2_1
nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
Y
0.013
10
RPL3: Protein component of the large (60S) ribosomal
DV[AV]A[RKQ]
subunit, has similarity to E.73
coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance
DEAD
of killer double1.E-04
stranded RNA virus
-1.2
nucleolus (1e-06)
0.008
9
PRP43: RNA helicase in the DEAH-box family, functions
[KDA]K.[KVA]K
in both RNA polymerase 73
I and polymerase
P.[ST]PKK.KK
II transcript
Cdc2
metabolism,
like protein
involved
kinase
in release
substrate
of themotif
lariat-intron
Helicase_C
from the spliceosome
1.E-02
-0.9
nucleolus (1e-33)
Y
0.013
10
matsuyama_periphery
S[LSF]..[VGK]S
73 S[ST]
MDC1 BRCT domain binding motif
Y
Pkinase
1.E-04
-0.7
barrier septum (1e-53)
Y
0.018
10
oshea_bud_neck
S[STV][SVK]S
73 S[ST]
RhoGAP
1.E-04
0.2
Y
0.014
10
nucleolus
DE[ADE][DSE]
73 YDE[PDV]
Y must be DEAD
phosphorylated) 1.E-08
2.5
nucleolus (1e-12)
Y
0.016
10
HP[NWP][IVF]
73 bodies
HPQ
at late anaphase;Biotin
promotes
binding
mitotic
motif
exit in
by streptavidin
directly switching
Y
on thePkinase
1.E-19
3.2
Y
0.008
10
SAS10: Component of the small (ribosomal) subunitKP[EDQ]N[ILF]
73for pre-18S
FKPYrRNa processing;
TLAessential
binding nucleolar
motif in Brinker
protein that,
transcription
when overproduced,
factor
Pkinase
fordisrupts
bindingsilencing
TLA
1.E-14
domain in Groucho
3.6
0.008
10
NOG1: Putative GTPase that associates with free 60S
[PET][TSE]REL
ribosomal subunits in the nucleolus
73 RE..E
and is required for Iron
60S ribosomal
binding motif
subunit
in biogenesis;
ferritin L-chain
constituent
Y and yeast
of 66S
DEAD
Iron
pre-ribosomal
transport particles;
protein
1.E-10 member4.5
of the ODN
ribosome
family of assembly
nucleolar G-proteins
(1e-12)
Y
0.008
9
W[SAG][LVC]G
73
Pkinase
1.E-65
6.9
Y
0.016
10
amine metabolism
[KD]MS[KAI]S
73 YMPMS
PI3 Kinase p85 SH2 domain binding motif
Y
0.009
10
NUP116: Subunit of the nuclear pore complex (NPC)
[AGE]FSF[GHK]
that is localized to both sides73
of the F.F
pore; contains a repetitive
WASPGLFG
Homology
motif that
1 binding
interacts motif
with mRNA export factor Mex67p and with karyopherin Kap95p;rRNA
homologous
exportto from
Nup100p
nucleus (1e-17)
Y
0.008
10
Run Details
Motif
ZKnown Match
score
Match details
Pos.
Bias
Best Domain
Best
Domain
pval
Domain
Overlap
Z-score
Best GO term
SP.[RK]
Cdc28p to promote
312
the transition
SP.[RK]
from G2 to M
CDK
phase;
kinase
accumulates
substrate
during
motif
G2 andYM, then targeted
Pkinase
via a destruction
1.E-04
box motif for -3.5
ubiquitin-mediated
cell cycle
degradation
Motif-Motif
Interaction?
Y
Y
Y
Y
yeast-413_GO-0005215
2 transporter activity
IA..[FIG][GFA]
72
Mito_carr
1.E-07
1.6
Y
0.015
10
protein_40_YDR060W
2 MAK21: Constituent of 66S pre-ribosomal particles,P[TLG]R[EQF]L
required for large (60S) ribosomal
72 subunit
[AG]R
biogenesis; involved
Protease
in nuclear
matriptase
export of
protease
pre-ribosomes;
site required DEAD
for maintenance of 1.E-06
dsRNA virus; homolog
3.5 of ATP-dependent
human CAATT-binding
RNA
protein
helicase activity (1e-07)
0.007
10
protein_40_YAR019C
2 CDC15: Protein kinase of the Mitotic Exit Network that
G[ILMV]..[LMY]H
1.E-20
4.8
Y
0.010
10
yeast-335_GO-0016772
2 transferase activity, transferring phosphorus-containing groups
[MRI]APE
72 P[TS]AP
LIG_PTAPLIG_PTAP
Pkinase
1.E-55
6.5
Y
0.016
10
yeast-565_GO-0006464
2 protein modification
HRD[ILMV][KLS]
MGMT PATTERN
Pkinase
1.E-55
6.7
protein amino acid phosphorylation (1e-63)
0.016
10
protein_40_YMR139W
2 RIM11: Protein kinase required for signal transduction
[GSQ]S..[ANV]SP
during entry into meiosis; promotes
72 SP
the formation of theERK1,
Ime1p-Ume6p
ERK2 Kinase
complexsubstrate
by phosphorylating
motif Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta
0.008
10
protein_40_YBR017C
2 KAP104: Transportin, cytosolic karyopherin beta 2 GG.[FGT]G[NSK]
involved in delivery of heterogeneous
72 nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role
nuclear
in cell-cycle
organization
progression and biogenesis (1e-06)
0.008
10
yeast-217_GO-0007046
2 ribosome biogenesis
[HFV]R.GR[TSA]
71 [AG]R
Protease matriptase protease site
DEAD
1.E-20
-2.2
Y
0.011
10
yeast-413_GO-0005215
[VGI]GI[VGA]
71
MFS_1
1.E-07
1.2
Y
0.015
10
yeast-238_GO-0017111
2 nucleoside-triphosphatase activity
LDE[PCH][TS]
71
ABC_tran
1.E-12
3.4
0.009
10
protein_40_YGL105W
2 ARC1: Protein that binds tRNA and methionyl- and glutamyl-tRNA
K[PAS].N[ILF]L
synthetases (Mes1p
the cytoplasm; 4.3
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-18)
Y
0.008
10
yeast-248_GO-0016072
2 rRNA metabolism
[HFG]R.GR[TRS]
71 [AG]R
Helicase_C
1.E-19
9.1
0.012
10
yeast-462_GO-0019222
2 regulation of metabolism
QQ[QIP]
70 S[QT]Q
ATM phosphorylation of this motif on Chk2 zf-C2H2
1.E-03
-1.6
Y
0.015
10
yeast-341_GO-0045449
2 regulation of transcription
[SAP]S..[NSP]S
70 S..[ST]
must first be -1.1
phosphorylated)
Y
0.014
10
protein_40_YPR119W
2 CLB2: B-type cyclin involved in cell cycle progression; activates
[EPA]K.R
Cdc28p to promote
70the transition
F.F.LK...K.R
from G2 to M
Phosphatidylserine
phase; accumulates binding
during G2motif
andYM,
in PKC
then targeted
Pkinase
via a destruction
1.E-07
box motif for ubiquitin-mediated
-1
cell cycle
degradation
Y
0.013
10
yeast-1062_GO-0016020
2 membrane
I[FIW]..V
70
Adaptin_N
1.E-03
0.6
Y
0.015
10
protein_40_YGR252W
2 GCN5: Histone acetyltransferase, acetylates N-terminal
RL.[RIY][RGL]G
lysines on histones H2B and
70 H3; RGG
catalytic subunit of the
Alternative
ADA and SAGA
integrin
histone
binding
acetyltransferase
site in FMDVcomplexes;
virus
Histone
founding member
1.E-06
of the Gcn5p-related
1.6
nuclear
N-acetyltransferase
nucleosome
superfamily
(1e-05)
0.007
10
protein_40_YNL186W
2 UBP10: Ubiquitin-specific protease that deubiquitinates
[TAI]D[FW]G
Y
regulating
Pkinase
Gap1p and 1.E-21
4.1
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-18)
Y
0.008
10
protein_40_YAR019C
[YWD][MLR].PE
70 bodies
[VIL].Y[MLF].P
at late anaphase;SHP1,
promotes
SHP2
mitotic
SH2
exitdomain
by directly
binding
switching
Y motif
on thePkinase
1.E-24
4.4
Y
0.011
10
protein_40_YOL012C
2 HTZ1: Histone variant H2AZ, exchanged for histone [VQ]LE[YFR]L
H2A in nucleosomes by the SWR1
70 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.007
10
protein_40_YFR034C
2 PHO4: Basic helix-loop-helix (bHLH) transcription factor
A[AGT]R[KYW]A
of the myc-family; binds cooperatively
70 [AG]R
with Pho2p to the
Protease
PHO5 promoter;
matriptase
function
protease
is regulated
site by phosphorylation at multiple sites and by phosphateribosome
availability (1e-04)
0.007
10
protein_40_YER110C
2 KAP123: Karyopherin beta, mediates nuclear import
GG.F[GWV][SRL]
of ribosomal proteins prior to 70
assembly
GGQ
into ribosomes and
N-methylation
import of histones
motifH3inand
E. coli,
H4; localizes
Gln
Y residue
to the in
nuclear
methylated,
pore, nucleus,
mimics
and
CCA
cytoplasm;
motif atexhibits
the end
snRNP
genetic
of tRNA
interactions
protein
molecule
import
with RAI1
into nucleus (1e-04)
Y
0.008
10
oshea_nuclear_periphery
2 oshea_nuclear_periphery
F[GDT].K[PHD]A
70
nuclear pore (1e-12)
0.009
10
yeast-217_GO-0007046
E[EDS]D[EID]
69 E[ST]D
Ankyrin G binding motif in KNCQ2 and KNCQ3
Helicase_C
potaqssium channels
1.E-03
-1
Y
0.015
10
yeast-413_GO-0005215
L[FYG].G[LIT]
69
Mito_carr
1.E-16
1.5
Y
0.015
10
protein_40_YNL186W
Y[RMT].P[EK]
may regulate
Y..P silencing by acting
SH2 ligand
on Sir4p;
group
involved
1B-Crk,
in posttranscriptionally
SH2 binding motif
regulating
Pkinase
for ITK,
Gap1p
Nckand
and1.E-23
possibly
RasGAP
other
to transporters;
Doc-R
3.5 (needs
protein
primarily
to be
kinase
located
Tyr phosphorylated)
activity
in the nucleus
(1e-20)
0.009
10
protein_40_YLL008W
2 DRS1: Nucleolar DEAD-box protein required for ribosome
DFG[MFL][ATV]
Pkinase
particles
1.E-15
3.7
0.007
10
yeast-324_GO-0030528
2 transcription regulator activity
R.[RPK]K
69
Zn_clus
1.E-16
13.5
transcription regulator activity (1e-19)
Y
0.014
10
protein_40_YOR174W
2 MED4: Subunit of the RNA polymerase II mediator complex;
M[QMV][QRI]Q
associates with core polymerase
69
subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
RNA polymerase II transcription mediator activity (1e-11)
0.007
10
protein_40_YHR196W
2 UTP9: Nucleolar protein, component of the small subunit
DE..[NAI]E[KGY]
(SSU) processome containing
69 the U3 snoRNA that is involved in processing of pre-18S rRNA
snoRNA binding (1e-08)
0.007
10
protein_40_YPL093W
2 NOG1: Putative GTPase that associates with free 60S
GR[TEF][AGK]R
68 [AG]R
60S ribosomal
matriptase
subunit biogenesis;
protease site
constituent of 66S
DEAD
1.E-11 member
-1.7
of the ODN
RNA
family
helicase
of nucleolar
activity
G-proteins
(1e-11)
0.007
10
yeast-504_GO-0006350
2 transcription
Q[QNH]Q
68
zf-C2H2
1.E-11
-0.9
0.014
10
oshea_nucleolus
2 oshea_nucleolus
[VSE][LES]DE
68 SEDEE
CKII kinase phosphorylation siteY(peptide screen)
DEAD
1.E-06
1.3
nucleolus (1e-72)
0.013
10
yeast-413_GO-0005215
A[LVI]..G[LFV]
68
Mito_carr
1.E-10
1.4
Y
0.014
10
yeast-1062_GO-0016020
2 membrane
I..[LFV]I
68
Y
MFS_1
1.E-08
1.5
Y
0.014
10
yeast-312_GO-0006414
2 translational elongation
D[DGN][DKQ]M
68
Y
Ribosomal_60s
1.E-11
1.6
Y
0.008
9
protein_40_YKL014C
2 URB1: Nucleolar protein required for the normal accumulation
T[GHW]..[KGH]TL
68 associated
PTL with the 27SA2
Motifpre-ribosomal
in Fos for proteosome
particle; proposed
degredation
to be involved
DEAD
2.9 subunit
0.007
10
yeast-1939_GO-0003824
2 catalytic activity
T..Y
68 [ST]FCGT.[ED]YPDK1 phosphorylation motif
Y
Pkinase
1.E-19
3.6
Y
(1e-61)0.015
10
protein_40_YNL272C
2 SEC2: Guanyl-nucleotide exchange factor for the small
[LKM]G..H[RDP]
Pkinase
1.E-12
3.7
Y
0.008
10
yeast-255_GO-0042254
2 ribosome biogenesis and assembly
E[EDK]..E[EKD]
67
WD40
1.E-02
-2.3
0.014
10
yeast-255_GO-0007028
2 cytoplasm organization and biogenesis
E[EDK]..E[EKD]
67
WD40
1.E-02
-2.3
0.014
10
protein_40_YOR272W
2 YTM1: Constituent of 66S pre-ribosomal particles, [RGT]R.[AGY]RA
required for maturation of the large
67 ribosomal
[AG]Rsubunit
DEAD
1.E-04
-1.1
ribosomal large subunit assembly and maintenance (1e-05)
Y
0.007
10
yeast-1974_GO-0005634
2 nucleus
LK
67 F.F.LK...K.R
Phosphatidylserine binding motif in PKC
WD40
1.E-07
-0.4
0.014
10
yeast-1721_GO-0016043
2 cell organization and biogenesis
Q.L[LSQ]
67
HEAT
1.E-06
1.4
cellular localization (1e-74)
0.013
10
yeast-312_GO-0006414
AA.G[DG]A
67
Ribosomal_60s
1.E-08
1.5
0.009
9
yeast-335_GO-0016772
[ILG]G.G
67 LG.GD
Aspartyl protease active site in Presenilin also
Pkinase
a YD motif 1.E-64
6
Y
(1e-16)0.014
10
yeast-685_GO-0016740
2 transferase activity
[ILH]G.G
67 LG.GD
Aspartyl protease active site in Presenilin
Y
also
Pkinase
a YD motif 1.E-48
6.8
Y
(1e-94)0.014
10
yeast-799_GO-0043233
2 organelle lumen
K[KRE][REH]K
67 KR
CLV_PCSK_PC1ET2_1
Y
0.014
10
yeast-799_GO-0031974
2 membrane-enclosed lumen
K[KRE][REH]K
67 KR
CLV_PCSK_PC1ET2_1
Y
0.014
10
yeast-240_GO-0006807
2 nitrogen compound metabolism
[KD]MS[KAI]S
67 YMPMS
Y
0.009
10
protein_40_YPL131W
2 RPL5: Protein component of the large (60S) ribosomal
[DAK]E.[EGW]DA
subunit with similarity to E. 67
coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly
ribosome assembly (0.01)
0.006
9
protein_40_YIL094C
2 LYS12: Homo-isocitrate dehydrogenase, an NAD-linked
[SYK]V..AL[NLA]
mitochondrial enzyme required
67 for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
Y
0.007
10
protein_40_YHR135C
2 YCK1: Palmitoylated, plasma membrane-bound casein
[SEN]D.D[SDE]
kinase I isoform; shares redundant
67 D.D
functions with Yck2p
Ribose
in morphogenesis,
moiety of UDP
proper
and
septin
manganese
assembly,binding
endocytic
site
trafficking;
in glucuronyl
provides
transferase
an essential function overlapping with that of Yck2p
0.012
10
protein_40_YGL180W
2 ATG1: Protein serine/threonine kinase, required for vesicle
[SNG]D..S
formation during autophagy
67 and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; forms a complex with Atg13p and Atg17p
0.012
10
yeast-235_GO-0009653
2 morphogenesis
[STL]S..[SAD]S
66 S..[ST]
Pkinase
must first be -4.6
phosphorylated)
cellular morphogenesis (1e-15)
0.014
10
yeast-235_GO-0000902
2 cellular morphogenesis
[STL]S..[SAD]S
66 S..[ST]
Pkinase
must first be -4.6
phosphorylated)
0.014
10
protein_40_YPR119W
L..T[QPD]
Cdc28p to promote
66the transition from G2 to M phase; accumulates during G2 and M, then targeted
Pkinase
via a destruction
1.E-02
box motif for -2.1
ubiquitin-mediated
mitotic degradation
cell cycle by
(1e-08)
the proteasome
0.012
10
protein_40_YDR145W
2 TAF12: Subunit (61/68 kDa) of TFIID and SAGA complexes,
NN[VNI][ELG]E
involved in RNA polymerase
66
II transcription initiation and in chromatin modification, similar to histone
Bromodomain
H2A
1.E-02
-0.6
transcription factor TFIID complex (1e-07)
0.007
10
yeast-413_GO-0005215
I[IFG].[LAI]V
66
AA_permease
1.E-05
0.5
0.014
10
yeast-1974_GO-0005634
2 nucleus
Q[QEK]Q
66
Helicase_C
1.E-04
0.5
Y
0.013
10
protein_40_YLL008W
EN..[LKG][DKG]K
including synthesis of 60S ribosomal subunits; constituent of 66SYpre-ribosomal
Pkinase
particles
1.E-03
2.5
cytoplasm organization and biogenesis (0.001)
0.007
10
protein_40_YGL135W
2 RPL1B: N-terminally acetylated protein component [TEA]RE[LAT]A
of the large (60S) ribosomal subunit,
66 nearly
[AG]R
identical to Rpl1Ap
Protease
and has
matriptase
similarity to
protease
E. coli L1site
and
Y rat L10a ribosomal
DEAD proteins; rpl1a
1.E-04
rpl1b double3null mutation
RNAishelicase
lethal
activity (0.001)
0.007
10
protein_40_YDL153C
2 SAS10: Component of the small (ribosomal) subunit (SSU)
[LIA]K..N.L
66for pre-18S rRNa processing; essential nucleolar protein that, when
Y overproduced,
Pkinase
disrupts silencing
1.E-24
4.2
Y
0.012
10
yeast-335_GO-0016772
2 transferase activity, transferring phosphorus-containing
PE[VNR][ILMV]
groups
66
Y
Pkinase
1.E-51
5.7
Y
(1e-74)0.014
10
yeast-544_GO-0016070
2 RNA metabolism
[KQG]K.[KSQ]K
66 P.[ST]PKK.KK Cdc2 like protein kinase substrate motif
RNA metabolism (1e-12)
Y
0.014
10
protein_40_YMR047C
2 NUP116: Subunit of the nuclear pore complex (NPC)
KP..[STG][FTH]G
of the KP..[QK]
LIG_SH3_4LIG_SH3_4
GLFG motif that interacts with Y
mRNA export factor Mex67p and with karyopherin Kap95p;snRNP
homologous
protein
to Nup100p
import into nucleus (1e-15)
0.007
10
protein_40_YML007W
2 YAP1: Basic leucine zipper (bZIP) transcription factor
QQ..M[QIV][QTA]
required for oxidative stress 66
tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus;
general
mediates
RNA
resistance
polymerase
to cadmium
II transcription factor activity (1e-06)
0.008
10
protein_40_YDR510W
2 SMT3: Ubiquitin-like protein of the SUMO family, conjugated
A[DVA]A
to lysine residues of target
66 proteins;
FED[LV]IA[DE][PA]
regulates chromatid
CAVEOLIN
cohesion,
PATTERN
chromosome segregation,
Y
APC-mediated proteolysis, DNA replication and septin
carboxylic
ring dynamics
acid metabolism (1e-07)
0.012
10
protein_40_YBR106W
2 PHO88: Probable membrane protein, involved in phosphate
VS.L[VW][LCW]
transport; pho88 pho86
66double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
0.007
10
protein_40_YKL021C
2 MAK11: Protein involved in an early, nucleolar step ofH[RM].G[RDC]
60S ribosomal subunit biogenesis;
65 essential for cell growth and replication of killer M1 dsRNAYvirus; contains
DEAD
four beta-transducin
1.E-07
repeats -1.4
rRNA processing (1e-10)
0.007
10
protein_40_YKL014C
T[GQ].[GRE]KT
65 associated with the 27SA2 pre-ribosomal particle; proposed to be involved
Helicase_C
-1 subunit
Y
0.007
9
protein_40_YNL061W
2 NOP2: Probable RNA m(5)C methyltransferase, essential
K[KPV]..K[KRA]
for processing and maturation
65 ofP.[ST]PKK.KK
27S pre-rRNA andCdc2
large ribosomal
like protein
subunit
kinase
biogenesis;
substrate
localized
motif to the
DEAD
nucleolus; constituent
1.E-05
of 66S pre-ribosomal
-0.8
cytoplasm
particles
organization and biogenesis (1e-28)
Y
0.012
10
yeast-437_GO-0044429
2 mitochondrial part
D[ESD]D
65 D[SGDN]D[PE][LIVMF]D[LIVMGAC]
PPASE PATTERN
HEAT
1.E-02
0
cell cycle (1e-12)
0.014
10
oshea_microtubule
2 oshea_microtubule
DL.[GSF]S[EPQ]
65 DLL
Binding motif for clathrin heavy chain
Y
ear Kinesin
1.E-07
2.2
microtubule (1e-10)
0.009
10
yeast-685_GO-0016740
[KMN]P.[NVY]I
65
Y
Pkinase
1.E-31
4.5
Y
(1e-40)0.014
10
protein_40_YNL272C
[AS]PE[ILMV]
65cytoplasmic
SP vesicles; essential
ERK1,forERK2
post-Golgi
Kinase
vesicle
substrate
transport
motif
Pkinase
1.E-25
4.8
Y
0.012
10
protein_40_YJR002W
2 MPP10: Component of the SSU processome, which
LE..D[EQA][EDY]
is required for pre-18S rRNA processing,
65
interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
processing of 20S pre-rRNA (1e-12)
0.007
9
protein_40_YHR135C
2 YCK1: Palmitoylated, plasma membrane-bound casein kinase
S.[SEV]D
I isoform; shares redundant
65 HSTSDD
Branched
in morphogenesis,
chain alpha-ketoacid
proper septin assembly,
dehydrogenase
endocytickinase
trafficking;
substrate
provides
motif
an essential function overlapping with that of Yck2p
0.012
10
protein_40_YDL213C
2 NOP6: Putative RNA-binding protein implicated in [GPE]G..RG[GEI]
ribosome biogenesis; contains an
65RNARGG
recognition motif (RRM)
Alternative
and hasintegrin
similaritybinding
to hydrophilins;
site in
Y FMDV
NOP6 may
virus
be a fungal-specific gene as no homologs have
rRNA
beenprocessing
yet identified (0.01)
in higher eukaryotes
Y
0.007
10
yeast-388_GO-0007275
2 development
S[SGF]S[SRN]
64 S[ST]
Pkinase
1.E-05
-2.2
multicellular organismal development (1e-16)
0.013
10
yeast-251_GO-0005886
2 plasma membrane
TA[GSI]
64 [LIVM][ST]A[STAG]HC
TRYPSIN_HIS PATTERN
MFS_1
1.E-05
-0.5
plasma membrane (1e-15)
Y
0.013
10
matsuyama_nuclear_envelope_or_dots
2 matsuyama_nuclear_envelope_or_dots
S..[PDA]S
64 S...S
WD40 binding motif, Ser residues must be phosphorylated
IBN_N
1.E-03
0.3
nuclear envelope (1e-41)
0.015
10
yeast-312_GO-0006414
G[FTR]..[FQA]D
64 R..[PA]DG
LIG_TNKBMLIG_TNKBM
Y
Ribosomal_60s
1.E-11
1.6
Y
0.008
10
yeast-238_GO-0017111
[AVC]G...L
64
Ras
1.E-19
1.7
Y
0.013
10
yeast-238_GO-0017111
A[GDC]Q[ECM]
64
Y
Ras
1.E-32
2.6
Y
0.014
10
yeast-706_GO-0043412
2 biopolymer modification
HRD[ILMV][KLS]
MGMT PATTERN
Pkinase
1.E-53
6.9
0.014
10
yeast-685_GO-0016740
[DW][LI]KP
64 FKPY
TLA binding motif in Brinker transcription
Y
factor
Pkinase
for binding TLA
1.E-65
domain in Groucho
7
Y
0.014
10
yeast-335_GO-0016772
[ER]A..FK[LRP]
groups
64 KR
CLV_PCSK_PC1ET2_1
Y
transferase activity, transferring phosphorus-containing groups (1e-10)0.008
10
protein_40_YMR117C
2 SPC24: Component of the evolutionarily conservedEI.N[KSR][EVQ]
kinetochore-associated Ndc8064
complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.006
9
protein_40_YLL011W
2 SOF1: Essential protein required for biogenesis of 40S
[SDL][KCQ].KNI
(small) ribosomal subunit; has
64 similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
nucleolus (1e-07)
0.007
10
protein_40_YER177W
2 BMH1: 14-3-3 protein, major isoform; controls proteome
[DFK]NNS[NHM]
at post-transcriptional level,
64binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
Y
0.007
10
yeast-388_GO-0007275
2 development
T..[SQP]N
63 T..[SA]
FHA of KAPP binding motif, Thr must be phosphorylated
SH3_1
1.E-02
-1.2
Y
0.013
10
yeast-436_GO-0031323
2 regulation of cellular metabolism
Q.Q
zf-C2H2
1.E-08
-0.8
regulation of cellular metabolism (10)
0.013
10
yeast-1134_GO-0044249
2 cellular biosynthesis
N.[SNY]S
63 N.[TS]
PH
1.E-04
-0.8
0.013
10
oshea_actin
2 oshea_actin
PPP.[PHY]
63 [DE]FPPP
EVH binding motif of Mena
Y
SH3_1
1.E-04
-0.7
actin cortical patch (1e-14)
0.007
10
protein_40_YHR052W
2 CIC1: Essential protein that interacts with proteasome
[VKY]K..K[KRH]
components and has a potential
63 role
KR
in proteasome substrate
CLV_PCSK_PC1ET2_1
specificity; also copurifies with 66S pre-ribosomal
Helicase_C
particles
1.E-04
0.2
Y
0.012
10
protein_40_YER148W
2 SPT15: TATA-binding protein, general transcription R[LAH].R[RYI]G
factor that interacts with other factors
63 to
R.[RK]R
form the preinitiation
CLV_PCSK_FUR_1
complex at promoters, essential for viability Histone
1.E-03
1.4
nuclear nucleosome (0.01)
0.007
10
protein_40_YBL002W
2 HTB2: One of two nearly identical (see HTB1) histone
RL.[RLT][RAP]G
H2B subtypes required for chromatin
63
assembly and chromosome function; Rad6p-Bre1p-Lge1p mediatedHistone
ubiquitination regulates
1.E-08
transcriptional
1.8 activation,
nuclear
meiotic
nucleosome
DSB formation
(1e-08)
and H3 methylation
Y
0.007
10
yeast-238_GO-0017111
NK.[DM][LVR]
63 NK.D
Motif for specificity of guanine in purine binding
Ras
proteins
1.E-14
2.4
Y
0.014
10
protein_40_YHR030C
2 SLT2: Serine/threonine MAP kinase involved in regulating
V[DWP].W[SAQ]
the maintenance of cell 63
wall integrity
VP and progression
Interleukin
through the
converting
cell cycle; regulated
enzyme protease
by the PKC1-mediated
Pkinasesignaling pathway
1.E-07
3.8
10
yeast-335_GO-0016772
HP[NFW][ILT]
groups
63 HPQ
Biotin binding motif in streptavidin
Pkinase
1.E-30
4.6
Y
(1e-42)0.014
10
yeast-799_GO-0043233
2 organelle lumen
EED[EAK][DGL]
63 EED
Ankyrin B C-terminal motif that binds internal Ankyrin repeats
0.013
10
yeast-799_GO-0031974
2 membrane-enclosed lumen
EED[EAK][DGL]
63 EED
0.013
10
protein_40_YLR175W
2 CBF5: Pseudouridine synthase catalytic subunit of RGG[SAK][RSE]
box H/ACA small nucleolar ribonucleoprotein
63 GGRGG
particles (snoRNPs),
Arginineacts
methyl
on both
transferease
large and small
substrate
rRNAs and
motif
on(PRMT1)
snRNA U2
0.006
10
protein_40_YHR099W
2 TRA1: Subunit of SAGA and NuA4 histone acetyltransferase
[LGF]L..Q[QFS]Q
complexes; interacts 63
with acidic
SQactivators (e.g., ATM
Gal4p)kinase
which leads
substrate
to transcription
motif
activation; similar to human TRRAP, which is a cofactor for c-Myc
histone
mediated
acetylation
oncogenic
(1e-08)
transformation
0.007
8
yeast-792_GO-0006412
2 protein biosynthesis
N.[NSY]S
62 N.[TS]
Y
Zn_clus
1.E-04
-2.1
0.013
10
oshea_bud_neck
2 oshea_bud_neck
S..N[SRF]
62
Y
RhoGAP
1.E-06
-0.6
Y
0.012
10
yeast-376_GO-0019219
2 regulation of nucleobase, nucleoside, nucleotide and nucleic
QQ..[LPN]
acid metabolism
62
zf-C2H2
1.E-10
-0.5
Y
acid metabolism
0.013 (1e-14)
10
protein_40_YOL069W
2 NUF2: Component of the evolutionarily conserved kinetochore-associated
K[LQM]N[DNE] Ndc80 complex
62 KEN
(Ndc80p-Nuf2p-Spc24p-Spc25p);
LIG_APCC_KENbox_2
involved in chromosome segregation,
SMC_N
spindle checkpoint
1.E-03
activity and kinetochore
0.2
microtubule
clustering
cytoskeleton (1e-06)
0.012
10
yeast-1062_GO-0016020
2 membrane
AF..[LGS]
62 F..LF
Androgen receptor motif that interacts
Y
with AF2
MFS_1
1.E-11
0.9
endomembrane system (1e-43)
Y
0.013
10
protein_40_YLR340W
2 RPP0: Conserved ribosomal protein P0 similar to rat
SD[DGS][DVK]M
P0, human P0, and E. coli L10e;
62 shown to be phosphorylated on serine 302
Ribosomal_60s
1.E-07
0.9
0.007
8
yeast-312_GO-0006414
EE..DD[MV]
62 EED
Ankyrin B C-terminal motif that binds internal
Ribosomal_60s
1.6
Y
0.008
10
protein_40_YGR252W
V[LYG]EY[LY]
62 H3; [DE]YY
TyrADA
phosphorylated
and SAGA histone
in activation
acetyltransferase
loop of complexes;
JakHistone
founding member
1.E-03
1.6
SAGA
N-acetyltransferase
complex (0.01)
superfamily
0.007
10
protein_40_YPL031C
2 PHO85: Cyclin-dependent kinase, with ten cyclin partners;
[RHN]D..P[ELW]N
involved in regulating the
62cellular response to nutrient levels and environmental conditions and progression
Pkinase
through the cell
1.E-07
cycle
3.4
0.007
9
yeast-207_GO-0003677
2 DNA binding
KR[KRA]
62 KR
CLV_PCSK_PC1ET2_1
Zn_clus
1.E-09
6.5
DNA binding (1e-17)
Y
0.013
10
protein_40_YMR229C
2 RRP5: Protein required for the synthesis of both 18SKK[SDL][KRA]
and 5.8S rRNA; C-terminal region
62 isKKSRGDYMTMQIG
crucial for the formation
Insulin
of 18S
receptor
rRNA and
kinase
N-terminal
substrate
region
motif
is required for the 5.8S rRNA; component of small ribosomal
nucleolus
subunit(1e-28)
(SSU) processosome
0.011
10
protein_40_YGL180W
2 ATG1: Protein serine/threonine kinase, required for vesicle
KK[KRS]
62 and
KKKKKK[ST]
the cytoplasm-to-vacuole
TGF beta
targeting
receptor
(Cvt)kinase
pathway;
substrate
structurally
motif
required for pre-autophagosome formation; forms arRNA
complex
processing
with Atg13p (0.01)
and Atg17p
0.011
10
protein_40_YGL120C
2 PRP43: RNA helicase in the DEAH-box family, functions
E[EDV].E[EDK]
I and polymerase
SEDEE II transcript
CKII
metabolism,
kinase phosphorylation
involved in releasesite
of the
(peptide
lariat-intron
screen)
nucleolus (1e-30)
0.011
10
protein_40_YGL059W
2 PKP2: Mitochondrial protein kinase that negatively regulates
R[RQK][ARK]S
activity of the pyruvate
62dehydrogenase
R[KER].Scomplex PKC
by phosphorylating
epsilon kinase
the substrate
ser-133 residue
motifof the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p
0.012
10
protein_40_YGL030W
NK.[KQR][KFN]V
subunit, has similarity to rat
62L30 ribosomal protein; involved in pre-rRNA processing in the Y
nucleolus; autoregulates splicing of its transcript
nucleolus (0.01)
Y
0.007
10
oshea_mitochondrion
2 oshea_mitochondrion
[DNEQ]EE[DCS]
61 EED
Ankyrin B C-terminal motif that binds internalHEAT
-1.1
0.012
10
yeast-1721_GO-0016043
NK..[ERK][LSA]
61 K[KR].[KR]
PI3_PI4_kinase
1.E-02
-0.8
Y
0.012
10
protein_40_YPR119W
E...D[LSI]
Cdc28p to promote
Pkinase
via a destruction
1.E-04
box motif for -0.3
ubiquitin-mediated
cell cycle
degradation
Y
0.011
10
protein_40_YOR063W
2 RPL3: Protein component of the large (60S) ribosomal K..[AKR]A
coli L3K[KR].[KR]
and rat L3 ribosomal
Nuclear
proteins;localization
involved in the
motif
replication and maintenance
DEAD
of killer double1.E-02
stranded RNA virus
0.2
cytosolic ribosome (sensu Eukaryota) (1e-35)
Y
0.011
10
yeast-312_GO-0006414
[FRG]G.F[DN]
61 GCF
Motif for covalent cholesterol attachment
Y
Ribosomal_60s
at Cys
1.E-11
1.6
Y
0.007
10
protein_40_YNL031C
2 HHT2: One of two identical histone H3 proteins (seeR[LST].[RLV]RG
also HHT1); core histone required
61 for[KR]R
chromatin assembly,
CLV_PCSK_KEX2_1
involved in heterochromatin-mediated telomericHistone
and HM silencing; regulated
1.E-06 by acetylation,
1.6
methylation,
nuclear chromatin
and mitotic phosphorylation
(1e-05)
Y
0.007
8
yeast-248_GO-0031966
2 mitochondrial membrane
[LFV]D..[KR]TR
61
Y
Mito_carr
1.E-26
1.9
mitochondrial membrane (1e-15)
0.010
10
protein_40_YML073C
2 RPL6A: N-terminally acetylated protein component TRE[LTV][AQK]
61 has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
DEAD
1.E-04
2.9
RNA helicase activity (1e-04)
0.006
10
protein_40_YGR128C
2 UTP8: Nucleolar protein required for export of tRNAs[IMP]K.W[DNP]
from the nucleus; also copurifies
61 with the small subunit (SSU) processome containing the U3 snoRNA that WD40
is involved in processing
1.E-07
of pre-18S3.1
rRNA small nucleolar ribonucleoprotein complex (1e-11)
Y
0.006
10
protein_40_YDL153C
2 SAS10: Component of the small (ribosomal) subunit[IWF]K.EN[VCI]
61for pre-18S
[VILAFP]K.E
rRNa processing;
Motifessential
recognized
nucleolar
for modification
protein that, when
by SUMO-1
overproduced,
Pkinase
disrupts silencing
1.E-08
3.2
0.007
9
protein_40_YGL105W
W[SA].G[ICV]
synthetases (Mes1p
the cytoplasm; 4.5
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-20)
Y
0.008
10
protein_40_YPL153C
2 RAD53: Protein kinase, required for cell-cycle arrest [NIT]SN[NRA]
in response to DNA damage; 61
activated by trans autophosphorylation when interacting with hyperphosphorylated
Y
Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
Y
0.011
10
matsuyama_vacuole
2 matsuyama_vacuole
LY.[LAD]F[TID]
61 [IVL]Y..[PF]
ABL phosphorylation site
vacuole (1e-12)
0.009
8
protein_40_YBR160W
2 CDC28: Catalytic subunit of the main cell cycle cyclin-dependent
I[NDM][EY]LG
60
associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
0.007
9
yeast-256_GO-0016462
protein_40_YPL131W
protein_40_YHR052W
yeast-251_GO-0005886
protein_40_YDR303C
yeast-248_GO-0016072
protein_40_YMR229C
yeast-238_GO-0017111
yeast-256_GO-0016462
yeast-706_GO-0043412
yeast-335_GO-0016772
yeast-324_GO-0030528
protein_40_YMR236W
protein_40_YLR432W
protein_40_YIL094C
protein_40_YGL019W
protein_40_YDL055C
protein_40_YBR106W
yeast-630_GO-0051244
yeast-460_GO-0006351
protein_40_YOR117W
protein_40_YJL109C
protein_40_YDL140C
yeast-256_GO-0016462
protein_40_YGL245W
yeast-1939_GO-0003824
yeast-685_GO-0016740
yeast-504_GO-0006350
protein_40_YNL178W
protein_40_YMR047C
protein_40_YJL187C
protein_40_YFR001W
protein_40_YER177W
protein_40_YDL083C
protein_40_YDL014W
protein_40_YLR029C
yeast-631_GO-0050794
yeast-294_GO-0006366
yeast-345_GO-0006396
matsuyama_Golgi
yeast-980_GO-0051179
yeast-251_GO-0005886
protein_40_YNL031C
protein_40_YPL211W
protein_40_YBL007C
protein_40_YGL245W
protein_40_YNL272C
protein_40_YOR181W
yeast-685_GO-0016740
yeast-565_GO-0006464
yeast-1939_GO-0003824
protein_40_YER165W
protein_40_YEL063C
oshea_ambiguous
protein_40_YPL211W
yeast-661_GO-0050789
protein_40_YLR029C
yeast-324_GO-0030528
protein_40_YLR293C
protein_40_YGR275W
protein_40_YDR224C
yeast-312_GO-0006414
protein_40_YDL213C
protein_40_YOR181W
yeast-248_GO-0016072
matsuyama_Cytosol
protein_40_YHR052W
yeast-685_GO-0016740
yeast-256_GO-0016462
yeast-648_GO-0050791
yeast-304_GO-0019752
yeast-304_GO-0006082
yeast-262_GO-0031224
yeast-256_GO-0016021
protein_40_YPL153C
protein_40_YOL127W
protein_40_YOL120C
protein_40_YMR308C
protein_40_YJL092W
protein_40_YER133W
protein_40_YDR477W
protein_40_YDR145W
protein_40_YDL055C
protein_40_YBR247C
oshea_vacuole
ucsf_loc_k_means_G6
protein_40_YPL211W
protein_40_YOR310C
protein_40_YPL043W
yeast-436_GO-0031323
protein_40_YOR272W
protein_40_YNL061W
protein_40_YKR081C
yeast-1721_GO-0016043
yeast-216_GO-0006325
yeast-216_GO-0006323
protein_40_YHR148W
yeast-251_GO-0005886
yeast-251_GO-0005886
yeast-312_GO-0006414
yeast-312_GO-0006414
yeast-284_GO-0005740
protein_40_YLR429W
yeast-256_GO-0016462
protein_40_YBR031W
protein_40_YOL139C
yeast-685_GO-0016740
yeast-301_GO-0044451
yeast-262_GO-0031224
protein_40_YPR144C
protein_40_YNL110C
protein_40_YMR093W
protein_40_YLR002C
protein_40_YJL010C
protein_40_YIL094C
protein_40_YHR114W
protein_40_YBR142W
protein_40_YBR106W
protein_40_YBR017C
protein_40_YBR160W
protein_40_YKL021C
matsuyama_nucleolus
yeast-256_GO-0016462
yeast-248_GO-0016072
protein_40_YOL127W
protein_40_YNL175C
protein_40_YDR060W
protein_40_YGL120C
yeast-856_GO-0009059
protein_40_YPL129W
yeast-1547_GO-0043283
protein_40_YJR002W
protein_40_YOL069W
yeast-413_GO-0005215
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
6
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
60 K..[ST]
PKA kinase substrate motif
E1-E2_ATPase
1.E-09
-1.2
0.009
1.E-05
-1.1
0.007
1.E-08
-0.9
0.006
F...F[AWC]
60 F..LF
Androgen receptor motif that interacts withSugar_tr
AF2
1.E-05
1
0.013
RSC3: Component of the RSC chromatin remodeling
RL.R[RSQ][GQV]
complex; essential gene required
60 for maintenance of proper ploidy and regulation of ribosomal protein genes
Histone
and the cell wall/stress
1.E-03response;1.4
highly similar
nuclear
to Rsc30p
nucleosome (0.001)
0.007
rRNA metabolism
[DKS]E[AED]D
60 EED
Ankyrin B C-terminal motif that binds
Y internalDEAD
3.1
Y
0.013
RRP5: Protein required for the synthesis of both 18S
[REV]D.KP[EHQ]
60 isP.[IV][ND]R..KP
SH3ofbinding
18S rRNA
motif
andfor
N-terminal
HBP STAM
region
and
is required
GRB2
Pkinase
for the 5.8S rRNA;1.E-13
component of small
3.7 ribosomal
protein
subunit
kinase
(SSU)
activity
processosome
(1e-13)
0.008
A[LIR]..P[GDI]R
60
Y
AAA
1.E-12
4.2
Y
0.008
[AER][RHE]..DIP
60
Y
Helicase_C
1.E-07
4.4
0.007
biopolymer modification
[KYF]..DFG
60
Pkinase
1.E-48
6.7
0.013
D[IWV]..[LVC]G
groups
60
Pkinase
1.E-54
6.9
phosphotransferase activity, alcohol group as acceptor (1e-57)
Y
0.013
transcription regulator activity
C[NDA].C[GRQ]L
60 C..C
Motif on TIM mitochondrial translocation proteins
GATA
1.E-16
7.8
0.010
TAF9: Subunit (17 kDa) of TFIID and SAGA complexes,
[QRE]Q..Q[GIT]Q
60 II transcription initiation and in chromatin modification, similarYto histone H3
SLIK (SAGA-like) complex (1e-07)
0.007
IMD3: Inosine monophosphate dehydrogenase, catalyzes
[AIL][ESP]..AAE
the first step of GMP biosynthesis,
60
member of a four-gene family in S. cerevisiae, constitutively expressed
0.006
LYS12: Homo-isocitrate dehydrogenase, an NAD-linked
SE.[KHV]E[NAR]
60 for[ST]E
the fourth step in the
G protein-coupled
biosynthesis of lysine,
receptor
in which
kinase
homo-isocitrate
1 substrate
is oxidatively
motif
decarboxylated to alpha-ketoadipate
Y
0.006
CKB1: Beta regulatory subunit of casein kinase 2, a DE[ESA][DRT]
60 in cell
SEDEE
CKII kinase
the holoenzyme
phosphorylation
also contains
site CKA1,
(peptide
CKA2
screen)
and CKB2, the many substrates include transcription
RNA elongation
factors andfrom
all RNA
RNA
polymerases
0.012
PSA1: GDP-mannose pyrophosphorylase (mannose-1-phosphate
E[IGD]LD[LMA]
guanyltransferase),
60 synthesizes GDP-mannose from GTP and mannose-1-phosphate
Y
in cell wall biosynthesis; required for normal cell wall structure
0.007
PHO88: Probable membrane protein, involved in phosphate
IL[YC]L[LTM]
0.006
regulation of cellular physiological process
EE[DEI]
59 EE[DE]IYFFFF CSK kinase substrate motif
Zn_clus
1.E-03
-1.1
0.012
transcription, DNA-dependent
N[NHP]..N[SDQ]
59
Zn_clus
1.E-04
-0.8
transcription, DNA-dependent (1e-91)
0.012
RPT5: One of six ATPases of the 19S regulatory particle
L[KID][NPG]DL
of the 26S proteasome involved
59 WDL
in the degradation ofBinding
ubiquitinated
motifsubstrates;
for AP-2 and
recruited
clathrin
to the
heavy
GAL1-10
chain
promoter
PCI
ear region upon
1.E-06
induction of0.1
transcription
proteasome complex (sensu Eukaryota) (1e-10)
0.006
UTP10: Nucleolar protein, component of the small subunit
[LQR]LA[VIP]G
WD40
1.E-05
0.8
small nucleolar ribonucleoprotein complex (1e-06)
0.006
RPO21: RNA polymerase II largest subunit B220, part
[FLN]GL[AKL]R
of central core; phosphorylation
59 of [KR]R
C-terminal heptapeptide
CLV_PCSK_KEX2_1
repeat domain regulates association
Y with transcription
Pkinaseand splicing
1.E-02
factors; similar1.4
to bacterial
cyclin-dependent
beta-prime
protein kinase activity (0.001)
0.006
[NTH]K.D[LQM]
59 [NT]K.D
Motif for binding guanine nucleotides
Y
Ras
1.E-18
2.5
pyrophosphatase activity (1e-56)
Y
0.013
GUS1: Glutamyl-tRNA synthetase (GluRS), forms aW[SAR][LCM]G
Pkinase
of both tRNA1.E-15
synthetases and
4.4
ensuresprotein
their correct
kinase
localization
activity
to the
(1e-15)
cytoplasm
0.008
catalytic activity
[WHV]S[LFV]G
59 RR.S[MILVFY] PKA kinase substrate motif
Y
Pkinase
1.E-25
5.4
Y
0.012
[LIG]K.[EMA]N
59 [VILAFP]K.E Motif recognized for modificationYby SUMO-1
Pkinase
1.E-65
7.9
Y
0.012
transcription
[CAF]R.[RKW]K
59 R.RKGSF
PKC delta kinase substrate motifY
Zn_clus
1.E-20
18.1
0.013
RPS3: Protein component of the small (40S) ribosomal
A[PA]..K[VEG]V
subunit, has apurinic/apyrimidinic
59
(AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
ribosome (0.001)
0.006
FG..N[NKT][NM]
of the G[SA]LNK
GDP-mannose
GLFG motifbinding
that interacts
motifwith
in transporter
Y
mRNA export factor Mex67p and with karyopherin Kap95p;snRNP
homologous
protein
to Nup100p
0.007
SWE1: Protein kinase that regulates the G2/M transition
SD.[SDW][DSR]
by inhibition of Cdc28p kinase
59 activity;
D.D localizes to theRibose
nucleusmoiety
and to of
theUDP
daughter
andside
manganese
of the mother-bud
bindingneck;
site in
homolog
glucuronyl
of S. pombe
transferase
Wee1p; potential Cdc28p substrate
0.011
LOC1: Nuclear protein involved in asymmetric localization
[KRT]K..K[EGA]Q
of ASH1 mRNA; binds double-stranded
59 P.[ST]PKK.KK
RNA in vitro;
Cdc2
constituent
like protein
of 66Skinase
pre-ribosomal
substrate
particles
motif
0.006
BMH1: 14-3-3 protein, major isoform; controls proteome
[SQP]S..T[SMF]N
59bindsS..[ST]
proteins and DNA,Casein
involvedKinase
in regulation
I consensus
of many processes
phosphorylation
including site
exocytosis,
(N-term
vesicle
Ser must
transport,
first Ras/MAPK
be phosphorylated)
signaling, and rapamycin-sensitive signaling
Y
0.006
RPS16B: Protein component of the small (40S) ribosomal
[VMY][APL]KKR
subunit; identical to Rps16Ap
59 and
KRhas similarity to E.
CLV_PCSK_PC1ET2_1
coli S9 and rat S16 ribosomal proteins
ribonucleoprotein complex (1e-04)
Y
0.006
NOP1: Nucleolar protein, component of the small subunit
E[EDS]..E[ERD]
processome complex, which
59 is required
[ST]..Efor processing
Casien
of pre-18S
kinase
rRNA;
II consensus
has similarity
phosphorylation
to mammalian fibrillarin
site
nucleolus (1e-40)
0.011
RPL15A: Protein component of the large (60S) ribosomal
GR..[RSV]A[GRA]
subunit, nearly identical 58
to Rpl15Bp
[AG]R
and has similarity
Protease
to rat L15
matriptase
ribosomal protein;
protease
binds
site
to 5.8 S rRNA
DEAD
1.E-05
-1.3
0.006
regulation of cellular process
EE[DEI]
Zn_clus
1.E-03
-1.1
0.012
transcription from RNA polymerase II promoter
N[DNS].[SNH]N
58
Zn_clus
1.E-03
-0.9
transcription from RNA polymerase II promoter (1e-10)
0.012
RNA processing
[KNP]K.K[RKT]
DEAD
1.E-03
-0.8
RNA processing (1e-12)
0.012
matsuyama_Golgi
I..[LFV]F
58 D..SII.FF
CK I delta kinase phosphorylation site (peptide
zf-DHHC
screen)
1.E-03
0
Y
0.014
localization
I..[LFW]I
58
MFS_1
1.E-09
0.8
Y
0.012
plasma membrane
I[GAD]..[VFI]G
58
MFS_1
1.E-02
1.2
0.012
HHT2: One of two identical histone H3 proteins (see I[RIS].[DIE]DE
58 forSEDEE
chromatin assembly,
CKII
involved
kinase
in heterochromatin-mediated
phosphorylation site (peptide
telomeric
screen)
Histone
1.6
methylation,
establishment
and mitotic
and/or
phosphorylation
maintenance of chromatin architecture
Y (0.001) 0.006
NIP7: Nucleolar protein required for 60S ribosome subunit
K[TIR]AA[FLS]
biogenesis, constituent 58
of 66S KR
CLV_PCSK_PC1ET2_1
physically interacts with Nop8p and the exosome
DEAD
subunit Rrp43p 1.E-02
2.8
0.006
SLA1: Cytoskeletal protein binding protein required [HMT]RD[LIM]K
for assembly of the cortical actin
58cytoskeleton; interacts with proteins regulating actin dynamics and proteinsPkinase
required for endocytosis;
1.E-13
found in the
3.8nucleusprotein
and cellkinase
cortex; has
activity
3 SH3(1e-13)
domains
0.007
GUS1: Glutamyl-tRNA synthetase (GluRS), forms a complex
D[FW]G[LMF]
with methionyl-tRNA 58
synthetase
[GD][FYWA]G[LIVM][LIVMFYD]G[KN][NHW]
(Mes1p) and Arc1p;
CAP_GLY_1
complex formation
PATTERN
increases the catalytic efficiency
Pkinase
of both tRNA1.E-19
synthetases and4ensuresprotein
their correct
kinase
localization
activity
to the
(1e-18)
cytoplasm
0.008
[VFM]A[IVQ]K
58cytoplasmic vesicles; essential for post-Golgi vesicle transportY
Pkinase
1.E-19
4.4
Y
0.010
LAS17: Actin assembly factor, activates the Arp2/3 protein
[FI][PC].NYV
complex that nucleates 58
branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog
SH3_1 of the human
1.E-14
Wiskott-Aldrich
5.2syndrome protein (WASP)
0.007
[VAC]D.WS
58
Pkinase
1.E-37
5.6
0.013
protein modification
K[ILY].[DSP]FG
58
Pkinase
1.E-47
6.4
0.013
catalytic activity
W[SAD].G[CVL]
58
Y
Pkinase
1.E-50
6.4
0.012
PAB1: Poly(A) binding protein, part of the 3'-end RNA-processing
ST..G[GQA][LSM]
complex, mediates
58 interactions
S[ST] between theMDC1
5' cap structure
BRCT domain
and the binding
3' mRNAmotif
poly(A) tail, involved in control of poly(A) tail length, interactsprotein
with translation
exportfactor
from
eIF-4G
nucleus (1e-06)
0.007
CAN1: Plasma membrane arginine permease, requires
I[TAM][YMC]N
phosphatidyl ethanolamine58
(PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance
endoplasmic reticulum (0.01)
0.006
oshea_ambiguous
SS.[SEF][STA]
58 S[ST]
bud (1e-07)
Y
0.011
R[GS].[DAQ]IP
of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome
DEAD
-1.1
Y
0.007
EE[DIE]
Zn_clus
1.E-02
-1
0.012
DV[AVE]A[RKP]
to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
DEAD
1.E-02
-1
nucleolus (0.001)
0.006
[SNV]P.T[TNM]
57 [ST]P
LIG_WW_4LIG_WW_4
zf-C2H2
1.E-04
-0.9
0.012
GSP1: GTP binding protein (mammalian Ranp homolog)
F[LYH]S[QKA]L
involved in the maintenance
57 of nuclear
SQ organization,ATM
RNA processing
kinase substrate
and transport;
motif regulated by Prp20p,
HEAT
Rna1p, Yrb1p, Yrb2p,
1.E-02
Yrp4p, Yrb30p,
-0.8 Cse1p
protein
and Kap95p;
carrieryeast
activity
Gsp2p
(1e-05)
homolog
0.006
RTT102: Component of both the SWI/SNF and RSC
L[QSK]..[QDT]QQ
chromatin remodeling complexes,
57 suggested role in chromosome maintenance; possible weak regulator
Bromodomain
of Ty1 transposition 1.E-04
-0.8
chromatin remodeling complex (1e-13)
0.006
HTB1: One of two nearly identical (see HTB2) histone
[LER]T..LE[YVA]
57 T..[IL]
assembly and chromosome
FHA2 binding
function;
motif,
Rad6p-Bre1p-Lge1p
Thr must be phosphorylated
mediatedHistone
1.E-03
transcriptional
1.5 activation,
nuclear
meiotic
chromatin
DSB formation
(0.001)
and H3 methylation
Y
0.006
M[GP]..L[FC]
57 M...L
PMSA motif for internalization Y
Ribosomal_60s
1.E-12
1.6
Y
0.008
NOP6: Putative RNA-binding protein implicated in ribosome
DG[TKR][VKI]R
biogenesis; contains an
57RNA[KR]R
CLV_PCSK_KEX2_1
and has similarity to hydrophilins;
Y NOP6 may WD40
be a fungal-specific1.E-02
gene as no homologs
2.4 have
ribosome
been yet biogenesis
identified in higher
(0.001)
eukaryotes
0.006
LAS17: Actin assembly factor, activates the Arp2/3 [LAG]Q.S[DSL]I
protein complex that nucleates 57
branched
S[ST]
actin filaments; localizes
MDC1 BRCT
with thedomain
Arp2/3 complex
bindingtomotif
actin patches; homolog
SH3_1 of the human
1.E-05
Wiskott-Aldrich
2.5syndrome
cellprotein
cortex(WASP)
(0.001)
0.006
rRNA metabolism
P[TGY]RE[LTQ]
57 [AG]R
DEAD
1.E-11
3.9
Y
0.008
matsuyama_Cytosol
D[FSV].L[SAM]
57
Pkinase
1.E-08
4.1
0.014
CIC1: Essential protein that interacts with proteasome
[DQG]EAD[RLS]
57 role
[LIVMF][LIVMF]DEAD[RKEN].[LIVMFYGSTN]
DEAD_ATP_HELICASE
specificity; also copurifies
PATTERN
with 66S pre-ribosomal
DEADparticles 1.E-09
4.2
0.006
KP[EQW][NR]
57 [WFY][KR]P[WFY]
LIG_WRPW_2
Pkinase
1.E-47
5.8
Y
0.012
R[GLT].DI[PN]
57
Helicase_C
1.E-09
5.9
Y
0.008
E[DNEQ][EDN]E
57 [KRHQSA][DENQ]EL
ER_TARGET PATTERN
0.012
carboxylic acid metabolism
[KD]MS[KAI]S
57 YMPMS
Y
0.008
organic acid metabolism
[KD]MS[KAI]S
57 YMPMS
Y
0.008
intrinsic to membrane
L[LIF]I[LFI]
57 L[IVLMF].[IVLMF][DE]
Y
0.012
integral to membrane
L[LIF]I[LFI]
57 L[IVLMF].[IVLMF][DE]
Y
integral to membrane (1e-88)
0.012
RAD53: Protein kinase, required for cell-cycle arrest in
E[DQ]I[GIM]E
response to DNA damage; 57
activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays
heterochromatin
a role in initiation of
formation
DNA replication
(0.001)
Y
0.006
RPL25: Primary rRNA-binding ribosomal protein component
N[KNV].[KQM]KV
of the large (60S) ribosomal
57 subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal nucleolus
motif
(0.001)
0.006
QK..[LAY]S[LKI]
subunit, identical to Rpl18Bp
57 and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation
0.006
PSE1: Karyopherin/importin that interacts with the nuclear
FG.K[PHV][ALV]
pore complex; acts as the
57nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
snRNP protein import into nucleus (1e-09)
0.006
SRS2: DNA helicase and DNA-dependent ATPase involved
N[VRA][LCE]AS
in DNA repair, needed57
for proper
YASI
timing of commitment
SHP2tophosphatase
meiotic recombination
substrate
andmotif
transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
Y
0.006
GLC7: Catalytic subunit of type 1 serine/threonine protein
P[SIM]..RS[RK]
phosphatase, involved in
57many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
Y
0.006
SNF1: AMP-activated serine/threonine protein kinase[SLV]S[SND]S
found in a complex containing
57Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
0.010
TAF12: Subunit (61/68 kDa) of TFIID and SAGA complexes,
L[ADW]..[RND]AK
57
II transcription initiation and in chromatin modification, similar
Y to histone H2A
0.006
A[DAV]..LL[DEH]
guanyltransferase),
57 synthesizes
[DE]..LLGDP-mannose
Di-Leu
from
acidic
GTP and
motif
mannose-1-phosphate
for receptor endocytosis
in cell wall
(recognized
biosynthesis;
by required
VHS domain
for normal
of GGA
cell wall
proteins)
structure
0.006
ENP1: Protein associated with U3 and U14 snoRNAs,
[LEW]KV[LPI]K
required for pre-rRNA processing
57 and
VP40S ribosomal subunit
Interleukin
synthesis;
converting
localizedenzyme
in the nucleus
protease
and concentrated in the nucleolus
35S primary transcript processing (0.001)
0.007
oshea_vacuole
V[FGY].[LAT]VG
57
storage vacuole (0.001)
0.007
Sub-cellular localization, 6 clusters
K[KRP].K
57 K[KR].[KR]
PHD
1.E-04
-1.3
0.035
KK..[KNH][KEV]
of 66S RKK.[ST]
ZIP physically
interacts with Nop8p
motif
and the exosome
DEAD
-1.5
0.010
NOP58: Protein involved in pre-rRNA processing, 18S
[GS]F..[RKH]GG
rRNA synthesis, and snoRNA
56synthesis;
RGGcomponent of Alternative
the small subunit
integrin
processome
binding complex,
site in FMDV
which virus
is required
RRM_1for processing
1.E-02
of pre-18S rRNA
-1.4
nucleolus (0.01)
0.006
NOP4: Nucleolar protein, essential for processing and
K[EKS]K[KIR]
maturation of 27S pre-rRNA56
and large
[KR][LIM]K[DE]K[LIM]PG
ribosomal subunit
DEHYDRIN_2
biogenesis; constituent
PATTERN
of 66S pre-ribosomal particles;
DEADcontains four1.E-02
RNA recognition
-1.3
motifs (RRMs)
nucleolus (1e-23)
Y
0.011
ND.[KDF]
56 D.D
Ribose moiety of UDP and manganese binding
zf-C2H2
site in glucuronyl
1.E-04
transferase
-1.1
Y
0.012
YTM1: Constituent of 66S pre-ribosomal particles, required
R[GPT].[DQF]IP
for maturation of the large
56 ribosomal subunit
Y
DEAD
1.E-05
-1.1
Y
0.007
NOP2: Probable RNA m(5)C methyltransferase, essential
R[GST].[DQF]IP
56 of 27S pre-rRNA and large ribosomal subunit biogenesis; Y
localized to the
DEAD
1.E-05
-1.1
ribosome
particles biogenesis (1e-08)
0.006
RPF2: Essential protein involved in the processing of
[KVH]K..K[KES]
pre-rRNA and the assembly 56
of the 60S
P.[ST]PKK.KK
ribosomal subunit;
Cdc2
interacts
like protein
with ribosomal
kinaseprotein
substrate
L11; localizes
motif Helicase_C
predominantly to the 1.E-03
-0.9 of 66S
cytoplasm
pre-ribosomal
organization
particles and biogenesis (1e-23)
0.010
cell organization and biogenesis
L[ETN]..L[EKV]
56 L..LL
Motif for interaction with nuclear receptors, docking
IBN_N motif for 1.E-03
p300 on p53 to
-0.8
promote
cellular
acetylation
localization (1e-37)
Y
0.012
establishment and/or maintenance of chromatin architecture
KR.[KLG]
56 KR
CLV_PCSK_PC1ET2_1
Bromodomain
1.E-04
-0.3
establishment and/or maintenance of chromatin architecture (1e-18) 0.012
DNA packaging
KR.[KLG]
56 KR
CLV_PCSK_PC1ET2_1
Bromodomain
1.E-04
-0.3
IMP3: Component of the SSU processome, which is[LQK]LA[VIA]G
required for pre-18S rRNA processing,
56
essential protein that interacts with Mpp10p and mediates interactions
WD40
of Imp4p and Mpp10p
1.E-04
with U3 snoRNA
1
nucleolus (1e-07)
0.006
plasma membrane
I..F[LAF]
56 D..SII.FF
CK I delta kinase phosphorylation site (peptide
MFS_1
screen)
1.E-07
1.1
0.012
plasma membrane
LG.[VGC][LTA]
56
MFS_1
1.E-06
1.1
0.012
G[FMY]G[LEI]
56 SG.G
Glycosaminoglycan attachment Y
site Ribosomal_60s
1.E-11
1.6
0.007
[AGT]A.[PKG]A
56
Y
Ribosomal_60s
1.E-10
1.6
Y
0.010
mitochondrial envelope
[DKP][VTC].KTR
56
Mito_carr
1.E-24
2
mitochondrial envelope (1e-17)
0.011
CRN1: Coronin, cortical actin cytoskeletal component
IG.[GRT][STI]F
that associates with the Arp2p/Arp3p
56
complex to regulate its activity; plays a role in regulation of actin patch
Pkinase
assembly
1.E-06
2.4
protein serine/threonine kinase activity (1e-07)
0.006
IF..[EVF][IRQ]D
56
AAA
1.E-05
2.6
Y
0.007
RPL4A: N-terminally acetylated protein component of
[GIK]KT[LIK]A
the large (60S) ribosomal subunit,
56 nearly
KTPAKEE
identical to Rpl4Bp
GSK-3,
andERK1,
has similarity
ERK2,
to CDK5
E. coli L4
substrate
and
Y rat L4motif
ribosomal
DEADproteins 1.E-04
3.1
nucleolus (1e-04)
Y
0.006
CDC33: Cytoplasmic mRNA cap binding protein; the
RD..[PLS][EDV]N
eIF4E-cap complex is responsible
56 for mediating cap-dependent mRNA translation via interactions with thePkinase
translation initiation 1.E-13
factor eIF4G (Tif4631p
4
orprotein
Tif4632p)kinase activity (1e-11)
0.006
PE[VNL][ILMV]
56
Pkinase
1.E-58
6.5
Y
(1e-60)0.012
nucleoplasm part
E[DRG].[DGN]E
56
nucleoplasm part (1e-89)
0.012
FG.K[PH][AN]
56
rRNA export from nucleus (1e-12)
0.007
NOC4: Nucleolar protein, forms a complex with Nop14p
KR..[ED][DEK]D
that mediates maturation 56
and nuclear
KR export of 40S ribosomal
CLV_PCSK_PC1ET2_1
subunits
Y
0.006
NOP15: Constituent of 66S pre-ribosomal particles,SEL[KGC][SMQ]
involved in 60S ribosomal subunit
56 biogenesis;
[ST]E localizes toGboth
protein-coupled
nucleolus and cytoplasm
receptor kinase 1 substrate motif
0.006
[KPY]K.LL[RFG]
56 DLL
the U3 snoRNA thatBinding
is involved
motif
in processing
for clathrin
of pre-18S
heavy chain
rRNA ear
nucleolus (0.001)
0.006
NOC3: Protein that forms a nuclear complex with Noc2p
[AGQ]T.KK[SDG]
that binds to 66S ribosomal
56precursors
RKK.[ST]
to mediate their
ZIPintranuclear
transport; also binds
motifto chromatin to promote the association of DNA replication factors and replication initiation
0.006
NOP9: Essential component of pre-40S ribosomes that
[GS]GR[GSV]G
is required for early cleavages
56 of 35S
[AG]R
pre-rRNA and hence
Protease
formation
matriptase
of 18S rRNA;
protease
bindssite
RNA in vitro and contains multiple pumilio-like repeats
0.007
[VGH][LC]GQ
56 forGGQ
N-methylation
biosynthesis of
motif
lysine,
in in
E.which
coli, Gln
homo-isocitrate
residue in ismethylated,
oxidatively decarboxylated
mimics CCA to
motif
alpha-ketoadipate
at the end of tRNA molecule
Y
0.007
BZZ1: SH3 domain protein implicated in the regulation
PPP[PIL][PGT]
of actin polymerization, able
56to recruit
[DE]FPPP
actin polymerization
EVHmachinery
binding motif
through
ofits
Mena
SH3 domains, colocalizes with cortical actin patches and Las17p, interacts
actin with
cortical
type Ipatch
myosins(0.001)
0.006
MAK5: Essential nucleolar protein, putative DEAD-box
[AD]D.E[RE]L
RNA helicase required for maintenance
56 D.E of M1 dsRNA virus;
Sec24pSec24pSec24p
involved in biogenesis of large (60S)
Y ribosomal subunits
nucleolus (0.001)
0.006
IG.[IAC][IVG]
0.011
KAP104: Transportin, cytosolic karyopherin beta 2 LF..K[PSF][AEK]
involved in delivery of heterogeneous
56 nuclear
LFG ribonucleoproteins
Protease
to the
Papain
nucleoplasm,
substrate,
bindsarg-nuclear
prototype
localization
cysteine signals
proteinase
on Nab2p and Hrp1p, plays a role
protein
in cell-cycle
import
progression
0.006
L..L[QEP]
55
associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct
Pkinase
the CDK to specific
1.E-06
substrates 0.3
cell cycle (1e-15)
0.010
MAK11: Protein involved in an early, nucleolar step EE..[EKD][KEY]
of 60S ribosomal subunit biogenesis;
55 essential
EED for cell growth
Ankyrin
and replication
B C-terminal
of killer
motif
M1 that
dsRNA
binds
virus;internal
contains
DEAD
Ankyrin
repeats1.E-02
repeats -1.8
nucleolus (1e-32)
Y
0.010
matsuyama_nucleolus
[RV][GP].DIP
55
DEAD
1.E-10
-1.6
0.008
DE[AVI][DHC]
55 YDE[PDV]
Y must Helicase_C
be phosphorylated) 1.E-24
-1.5
Y
0.012
rRNA metabolism
DV[AQW]A[RQ]
55
DEAD
1.E-07
-1.5
0.007
K..[RAK]A
55 subunit,
K[KR].[KR]
has similarity
Nuclear
to E. coli
localization
L23 and rat motif
L23a ribosomal proteins;
Ribosomal_60s
binds to 26S rRNA via
1.E-02
a conserved C-terminal
-1.4
cytosolic
motif
ribosome (sensu Eukaryota) (1e-41)
Y
0.010
NOP13: Protein of unknown function, localizes to the
G[RLS]TA[RPG]
nucleolus and nucleoplasm; 55
contains
KSGST
an RNA recognition
eIF4
motifmotif
(RRM)
phosphorylation
and has similaritymotif
to Nop12p, which DEAD
is required for processing
1.E-07of pre-18S
-1.2
rRNA RNA helicase activity (1e-06)
0.006
MAK21: Constituent of 66S pre-ribosomal particles,DV..R[GAD][LVA]
55 subunit biogenesis; involved in nuclear export of pre-ribosomes;
Y required DEAD
-1.2 of ATP-dependent
human CAATT-binding
RNA
protein
0.005
KR..[EDK][DKE]
I and polymerase
KR
II transcript
CLV_PCSK_PC1ET2_1
metabolism, involved in release of the lariat-intron
Helicase_C
1.E-03
-0.9
nucleolus (1e-29)
0.010
macromolecule biosynthesis
N.[SNY]S
55 N.[TS]
Y
PH
1.E-05
-0.6
0.011
TAF14: Subunit of TFIID, TFIIF, INO80, SWI/SNF, and
T[LPT].LE[SQN]
NuA3 complexes, involved 55
in RNA P.L
polymerase II transcription
Motif ininitiation
C-Fos and
for protein
in chromatin
instability
modification;Bromodomain
contains a YEATS domain
1.E-02
-0.4
0.006
N.[LDF]K
55
Helicase_C
1.E-03
0.1
protein modification (1e-80)
0.012
MPP10: Component of the SSU processome, whichLNK[LEP][ATP]
55 G[SA]LNK
interacts with and
GDP-mannose
controls the stability
binding
of Imp3p
motif and
in transporter
Imp4p, essential
WD40
for viability; similar
1.E-02
to human Mpp10p
0.1
0.006
NUF2: Component of the evolutionarily conserved [KEV]L..E[VKF]E
kinetochore-associated Ndc80 complex
55
(Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation,
SMC_N
spindle checkpoint
1.E-02
0.2
clustering
Y
0.006
transporter activity
FA[LVW][AVH]
55
MFS_1
1.E-06
0.8
Y
0.013
[DGE]K..T[LAH]T
R[GST].[DAQ]IP
coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60SDEAD
subunit assembly
[ILR]A.P[GYQ]R
60 role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal
Helicase_C
particles
plasma membrane
10
10
10
10
10
10
10
10
10
10
10
10
9
9
10
10
9
8
10
10
9
10
9
10
9
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
9
10
10
10
10
10
10
10
10
7
10
10
9
10
10
10
10
9
10
10
9
9
9
10
10
10
10
10
10
10
10
10
9
8
10
9
10
9
10
9
10
10
10
10
10
7
10
10
10
10
10
10
10
10
9
10
10
10
10
10
10
9
10
8
10
10
10
9
9
9
10
10
10
10
9
10
9
10
10
10
10
10
10
10
10
10
10
10
10
8
10
10
protein_40_YDR449C
protein_40_YLR197W
yeast-752_GO-0016787
protein_40_YKL021C
protein_40_YLL008W
protein_40_YJR066W
yeast-324_GO-0030528
yeast-322_GO-0005654
protein_40_YPR161C
protein_40_YPR034W
protein_40_YPL204W
protein_40_YPL153C
protein_40_YPL153C
protein_40_YPL093W
protein_40_YMR117C
protein_40_YML073C
protein_40_YML010W
protein_40_YLR429W
protein_40_YLR180W
protein_40_YIL144W
protein_40_YGR218W
protein_40_YGR086C
protein_40_YFR034C
protein_40_YER118C
protein_40_YDR448W
protein_40_YCR009C
protein_40_YBR059C
protein_40_YAR007C
yeast-410_GO-0007049
yeast-399_GO-0003723
oshea_mitochondrion
protein_40_YOL077C
yeast-410_GO-0007049
protein_40_YKL014C
yeast-207_GO-0003677
yeast-1721_GO-0016043
protein_40_YLR002C
protein_40_YPL198W
protein_40_YOR181W
yeast-661_GO-0050789
protein_40_YOR206W
yeast-312_GO-0006414
protein_40_YFL039C
matsuyama_periphery
protein_40_YNL186W
protein_40_YBR198C
protein_40_YDR356W
protein_40_YNL186W
yeast-1062_GO-0016020
yeast-304_GO-0019752
yeast-304_GO-0006082
protein_40_YKR048C
protein_40_YML069W
protein_40_YNL272C
protein_40_YPR137W
protein_40_YKL009W
protein_40_YKL021C
yeast-256_GO-0016462
protein_40_YAR019C
yeast-628_GO-0043037
protein_40_YOR326W
protein_40_YOR039W
protein_40_YOL120C
protein_40_YNL124W
protein_40_YNL118C
protein_40_YMR093W
protein_40_YLL011W
protein_40_YHR196W
protein_40_YGL173C
protein_40_YBR036C
protein_40_YAL024C
yeast-1166_GO-0005488
yeast-345_GO-0006396
yeast-1547_GO-0043283
protein_40_YDR496C
yeast-648_GO-0050791
yeast-238_GO-0017111
yeast-238_GO-0017111
protein_40_YOL127W
yeast-460_GO-0006351
protein_40_YJR066W
yeast-1721_GO-0016043
protein_40_YNL272C
protein_40_YBR106W
protein_40_YJR002W
protein_40_YAR019C
protein_40_YNL002C
protein_40_YGL245W
yeast-345_GO-0006396
yeast-685_GO-0016740
yeast-685_GO-0016740
yeast-685_GO-0016740
yeast-255_GO-0007028
yeast-255_GO-0042254
yeast-336_GO-0005783
yeast-335_GO-0016772
yeast-285_GO-0012505
yeast-256_GO-0016462
yeast-251_GO-0005886
yeast-234_GO-0006605
protein_40_YPR119W
protein_40_YPL240C
protein_40_YPL153C
protein_40_YPL153C
protein_40_YOL127W
protein_40_YMR093W
protein_40_YLR175W
protein_40_YKL009W
protein_40_YJR066W
protein_40_YJL095W
protein_40_YHR169W
protein_40_YGL173C
protein_40_YFL037W
protein_40_YER082C
protein_40_YDR381W
protein_40_YDR303C
protein_40_YDR174W
protein_40_YDL148C
protein_40_YDL148C
protein_40_YBR142W
protein_40_YAL032C
oshea_bud
protein_40_YDL188C
yeast-345_GO-0006396
protein_40_YML069W
yeast-460_GO-0006351
protein_40_YOL127W
yeast-256_GO-0016021
yeast-462_GO-0019222
protein_40_YML085C
protein_40_YKR081C
protein_40_YMR236W
yeast-942_GO-0043232
yeast-942_GO-0043228
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
[LQK]LA[VIA]G
WD40
1.E-04
1
nucleolus (1e-07)
0.006
10
0.010
10
2.7
0.013
10
2.7
nucleolus (1e-07)
0.006
10
I[GQL].G[SHQ]F
including
GCF
synthesis of 60S ribosomal
Motif for covalent
subunits; constituent
cholesterol
of attachment
66S pre-ribosomal
atPkinase
Cys
particles
1.E-04
3.3
Y
0.006
9
TOR1: PIK-related protein kinase and rapamycin target;
LF.[KHF][LM]H
subunit of TORC1, a complex
55 thatLFG
controls growth in Protease
response toPapain
nutrients
substrate,
by regulating
a prototype
translation,cysteine
transcription,
GATA
proteinase
ribosome1.E-06
biogenesis, nutrient
7 transport
regulation
and autophagy;
of nitrogen
involved
utilization
in meiosis (1e-07)
0.006
10
[ASG]C..C[RIQ]
55 C..C
Motif on TIM mitochondrial translocation
Y
proteins
Zn_clus
1.E-36
20.7
0.012
10
nucleoplasm
ED[EAK][DEG]
55 SEDEE
CKII kinase phosphorylation siteY(peptide screen)
nucleoplasm (1e-10)
Y
0.012
10
SGV1: Cyclin (Bur2p)-dependent protein kinase that
[EVA][ERD]..GDE
functions in transcriptional regulation;
55 RGD
phosphorylates theLIG_RGDLIG_RGD
carboxy-terminal domain of Rpo21p, which is the largest subunit of RNA polymerase II; regulated
nucleolus
by Cak1p(1e-06)
0.006
10
ARP7: Component of both the SWI/SNF and RSC L[QWG].[LTE]LK
chromatin remodeling complexes;
55 actin-related protein involved in transcriptional regulation
SWI/SNF complex (1e-05)
0.006
9
HRR25: Protein kinase involved in regulating diverse
[KHY]V[KDP]KV
events including vesicular trafficking,
55 VP
DNA repair, and chromosome
Interleukinsegregation;
converting binds
enzyme
the CTD
protease
of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
0.006
10
RAD53: Protein kinase, required for cell-cycle arrest in response
EQ[KVQ]
to DNA damage; 55
activated
[PG].[GS]C[GA]E[EQ].[LIVM]
by trans autophosphorylation
ALPHA_2_MACROGLOBULIN
when interacting with hyperphosphorylated
PATTERN
Rad9p; also interacts with ARS1 and plays
DNA
a role
integrity
in initiation
checkpoint
of DNA replication
(0.001)
Y
0.010
10
RAD53: Protein kinase, required for cell-cycle arrest
NN[SQL][NQK]R
activated
[KR]R
CLV_PCSK_KEX2_1
when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
Y
0.006
8
[KRH]K..K[EAR]
55 KR
and is required for CLV_PCSK_PC1ET2_1
60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN
cytoplasm
family of nucleolar
organization
G-proteins
and biogenesis (1e-30)
0.011
10
SPC24: Component of the evolutionarily conserved
[DHW]K..K[DMK]I
complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore
cytoskeletal
clustering part (0.01)
0.006
8
RPL6A: N-terminally acetylated protein component VVV[VSE][GHY]
55 has
VEHD
similarity to Rpl6Bp
Protease
and to rat
Caspase
L6 ribosomal
6-stringent
protein; binds to 5.8S rRNA
cytosol (0.001)
0.005
9
SPT5: Protein that forms a complex with Spt4p and[DGF]D..E[EDK]
mediates both activation and inhibition
55
of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing
Y
0.010
10
NK.[ELF][KCT]L
55
complex to regulate its activity; plays a role in regulation of actin patch assembly
0.006
10
SAM1: S-adenosylmethionine synthetase, catalyzes[IDF]LA[AWT]L
transfer of the adenosyl group55
of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
Y
0.006
9
TID3: Component of the evolutionarily conserved kinetochore-associated
[NPQ][EQL]..RLKNdc80 complex
55
(Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint
microtubule
activity, kinetochore
cytoskeleton
assembly
(0.001)
and clustering
0.006
8
CRM1: Major karyopherin, involved in export of proteins,
L[FHI].[NSI]NN
RNAs, and ribosomal subunits
55 from the nucleus
rRNA export from nucleus (0.001)
Y
0.006
9
PIL1: Primary component of eisosomes, which are[LPR]N..[QSG]QQ
large immobile cell cortex structures
55 associated
S[QT]Q with endocytosis;
ATM phosphorylation
null mutants showofactivation
this motif
of on
Pkc1p/Ypk1p
Chk2
stress resistance pathways; detected in phosphorylated state in mitochondria
0.006
9
PHO4: Basic helix-loop-helix (bHLH) transcription factor
A[LT].RA[LVC]
55
with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphatecytosol
availability
(0.01)
0.006
10
SHO1: Transmembrane osmosensor, participates inS[SFV]AS[RTG]
activation of both the Cdc42p-55
and MAP
S[ST]
kinase-dependent
MDC1
filamentous
BRCTgrowth
domain
pathway
binding
andmotif
the high-osmolarity glycerol response pathway
0.006
10
ADA2: Transcription coactivator, component of the L[LEK]..[QIV]QQ
ADA and SAGA transcriptional 55
adaptor/HAT (histone acetyltransferase) complexes
SAGA complex (1e-09)
0.006
10
RVS161: Amphiphysin-like lipid raft protein; subunit of
P[PIT].P[PN]R
a complex (Rvs161p-Rvs167p)
55 thatPPR
regulates polarization
LIG_WW_3LIG_WW_3
of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation
actin
or osmotic
cytoskeleton
stress
organization and biogenesis (0.01)
0.007
10
AKL1: Ser-Thr protein kinase, member (with Ark1p [SVI]S.DE[SWH]
and Prk1p) of the Ark kinase family;
55 involved
S.D in endocytosisCAMKII
and actin
phosphorylation
cytoskeleton organization
site
0.006
10
RFA1: Subunit of heterotrimeric Replication Protein P[EKF]LV[PTL]
A (RPA), which is a highly conserved
55 single-stranded
LVPRG
DNAProtease
binding protein
Thrombin
involved in DNA replication, repair, and recombination
replication fork (sensu Eukaryota) (0.01)
0.006
10
cell cycle
[SYI]S...S
54 S...S
WD40 binding motif, Ser residues must be Pkinase
phosphorylated 1.E-04
-4.8
cell cycle (10)
Y
0.011
10
RNA binding
RGG[FNQ][RFA]
54 GGRGG
Arginine methyl transferease substrate
Y
motif
RRM_1
(PRMT1)
1.E-07
-2.6
RNA binding (1e-09)
0.007
10
oshea_mitochondrion
N.N[SEN]
54
Zn_clus
1.E-11
-2.3
0.011
10
BRX1: Nucleolar protein, constituent of 66S pre-ribosomal
KK.[SVR][KEG]
particles; depletion leads
54to defects
RKK.[ST]
in rRNA processing
ZIP kinase
and a block
phosphorylation
in the assembly
motif
of large ribosomalBrix
subunits; possesses
1.E-02
a sigma(70)-like
-1.5 RNA-binding
cytoplasm
motif organization and biogenesis (1e-25)
0.010
10
cell cycle
L[LSQ]Q
54 LSQE
ATM kinase substrate motif
Pkinase
1.E-04
-1.4
cell cycle (1e-25)
Y
0.011
10
KK..[KDF][KEH]
54 associated
RKK.[ST]
with the 27SA2
ZIP kinase
pre-ribosomal
phosphorylation
particle; proposed
motif to be involved
Helicase_C
-1.3 subunit
0.010
10
DNA binding
N.N[TNF]
54
Zn_clus
1.E-08
-1.2
DNA binding (1e-15)
Y
0.011
10
[KNV]K.S[KEN]
54 RKK.[ST]
ZIP kinase phosphorylation motif
Helicase_C
1.E-02
-1.1
Y
0.011
10
[RVT]A[AG]R
54precursors
[AG]Rto mediate their
Protease
intranuclear
matriptase
transport;
protease
also bindssite
to chromatin toDEAD
promote the association
1.E-03of DNA replication
-1.1
nucleolus
factors and replication
(1e-06) initiation
0.007
10
RPL7B: Protein component of the large (60S) ribosomal
DVA[AQC][RTP]
subunit, nearly identical to54
Rpl7Ap
DVAD
and has similarity Protease
to E. coli L30
Caspase
and rat L7
2 -stringent
ribosomal proteins;
Y
contains
DEAD
1.E-02Nucleic acid
-1 Binding
ribosomal
Domain (NDB2)
large subunit assembly and maintenance (1e-05)
Y
0.006
9
[AVI]P..PP[AP]
branched
P..P
SH3 general
with theligand,
Arp2/3 complex to actin patches; homolog
SH3_1 of the human
1.E-05
Wiskott-Aldrich
-0.9syndrome
actin
protein
cortical
(WASP)
patch (1e-05)
Y
0.006
9
L.Q[DEP]
54 LSQE
Y
Zn_clus
1.E-02
-0.8
0.011
10
NOC2: Protein that forms a nucleolar complex with [TRI][GER].GKT
Mak21p that binds to 90S and 54
66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to Helicase_C
66S pre-ribosomes; both
1.E-09
complexes mediate
-0.8 intranuclear
RNA helicase
transportactivity
of ribosomal
(1e-10)
precursors
0.006
10
RGITI
54 FRGGT
Phosphoinositide binding motif in ATG18
GTP_EFTU_D2
and ATG21
1.E-08
-0.7
translation elongation factor activity (1e-08)
0.006
9
ACT1: Actin, structural protein involved in cell polarization,
[SLD]KR[YAD]S
endocytosis, and other 54
cytoskeletal
KR functions
CLV_PCSK_PC1ET2_1
SH3_1
1.E-02
-0.7
actin cytoskeleton organization and biogenesis (0.001)
0.006
10
matsuyama_periphery
A[SFD]S
54 C[SA]DSR[LIVM].[AP]
PROK_CO2_ANHYDRASE_1 PATTERN
PH
1.E-04
-0.7
Y
0.013
10
S[SI]PL[NKV]
may regulate
SP silencing by acting
ERK1,
onERK2
Sir4p; involved
Kinase in
substrate
posttranscriptionally
motif
regulating
Pkinase
Gap1p and 1.E-02
-0.6
primarily located in the nucleus
Y
0.005
8
NN[VNI]E[EV]
54 II transcription initiation and in chromatin modification
Bromodomain
1.E-02
-0.6
0.006
9
SPC110: Inner plaque spindle pole body (SPB) component,
[DS]V..AL[KGP]
ortholog of human kendrin;
54 involved in connecting nuclear microtubules to SPB; interacts
Y with Tub4p-complex
Kinesin and calmodulin;
1.E-02phosphorylated
0.3 byspindle
Mps1p inpole
cell cycle-dependent
body (1e-04)manner
Y
0.006
10
N[PKF]..R[IPD]
Pkinase
Gap1p and 1.E-10
0.9
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-10)
Y
0.009
10
membrane
A..F[GLA]
54
MFS_1
1.E-06
1
Y
0.011
10
V.[STA]G
54
PALP
1.E-02
1.4
carboxylic acid metabolism (1e-15)
0.011
10
V.[STA]G
54
PALP
1.E-02
1.4
0.011
10
NAP1: Protein that interacts with mitotic cyclin Clb2p;
YL..E[ILMV][LVM]
required for the regulation of54
microtubule
Y[LI]dynamics during
SH2
mitosis;
ligand
controls
for PLCgamma1
bud morphogenesis;
N-term.)group
involved Histone
in
3(phospho-peptide)
the transport of H2A
1.E-03
and H2B histones
1.5 to the nucleus; phosphorylated by CK2
Y
0.006
10
POB3: Subunit of the heterodimeric FACT complex [RT]L.R[RGV]G
(Spt16p-Pob3p), which facilitates
54 RNARGG
Pol II transcription Alternative
elongation through
integrin
nucleosomes
binding site
by in
destabilizing
FMDV virus
and
Histone
then reassembling
1.E-06
nucleosome 1.6
structure;nuclear
interacts with
nucleosome
DNA polymerase
(1e-06)
alpha (Pol1p)
0.006
10
K[IHR][IVP]H
54cytoplasmic
KR vesicles; essential
CLV_PCSK_PC1ET2_1
for post-Golgi vesicle transport
Pkinase
1.E-09
1.9
0.007
10
RRP9: Protein involved in pre-rRNA processing, associated
[IPM][KHG].WD
with U3 snRNP; component
54 ofPWDLW
small ribosomal subunit
(SSU) processosome; ortholog of the humanWD40
U3-55k protein 1.E-05
2.1
Y
0.006
8
MRT4: Protein involved in mRNA turnover and ribosome
[GKR]K.AA[FMS]
assembly, localizes to the54
nucleolus
DEAD
1.E-03
3.2
0.006
9
MAK11: Protein involved in an early, nucleolar step of[PT][TDE]REL
54 essential
RE..E for cell growth
Ironand
binding
replication
motifofinkiller
ferritin
M1 dsRNA
L-chain
Yvirus;
andcontains
yeast
DEAD
Iron
four transport
beta-transducin
protein
1.E-05
repeats
3.3
Y
0.007
10
PTR[EM][LIT]
54 P[ST]
DNA dependent Protein kinase substrate motif
DEAD
1.E-16
3.9
Y
0.008
10
CDC15: Protein kinase of the Mitotic Exit Network thatG[AST].G.V
1.E-20
4.5
0.008
9
translation
[KWV]MS[KAE]S
54 WM
Substrate binding motif of barley alpha-amylase 1 (AMY1) enzyme
0.009
10
MYO2: One of two type V myosin motors (along with[LM]EN[VAP]Q
MYO4) involved in actin-based
54transport
KENof cargos; required
LIG_APCC_KENbox_2
for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle
Y
0.007
9
CKB2: Beta' regulatory subunit of casein kinase 2,D[EDY]..DE[EDG]
a Ser/Thr protein kinase with roles
54 in cell
YDE[PDV]
SH2 ligand
the holoenzyme
for Nck1 and
also Nck2
contains
(Tyr
CKA1,
mustCKA2
be phosphorylated)
and CKB1, the many substrates include transcription
transcription
factorselongation
and all RNA polymerases
factor complex (1e-04)
0.008
10
[NIK]K.V[VMI]V
54 and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target
cytosolic
for Rnt1p large
cleavage
ribosomal
leading to subunit
degradation
(sensu Eukaryota) (1e-04)
0.006
8
NAF1: Protein required for the assembly of box H/ACA
ET.[KAY][ED]E
snoRNPs and for pre-rRNA54
processing,
T.Y forms a complex
MEK
withphosphorylation
Shq1p and interacts
of MAPK
with H/ACA
activation
snoRNPsite
components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins
0.006
8
DCP2: Catalytic subunit of the Dcp1p-Dcp2p decapping
D[DPK]..S[KQM]I
enzyme complex, which removes
54 DDDD..S
the 5' cap structureCasein
from mRNAs
kinase
prior
1 phosphorylation
to their degradation;
Ymotif
member of the Nudix hydrolase family
Y
0.006
9
[TIV]D.SK[RIY]
54 KR
the U3 snoRNA thatCLV_PCSK_PC1ET2_1
is involved in processing of pre-18S Y
rRNA
Y
0.006
7
SOF1: Essential protein required for biogenesis of [LDG]E..D[EKL]E
40S (small) ribosomal subunit; has
0.006
10
IS[KEC]A[SKR]
Y
0.006
9
KEM1: Evolutionarily-conserved 5'-3' exonuclease component
[GRK][GT]RGG
of cytoplasmic processing
54 (P)
RGG
bodies involved in
Alternative
mRNA decay;
integrin
plays binding
a role in microtubule-mediated
site in
Y FMDV virus processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance
0.006
9
CSG2: Endoplasmic reticulum membrane protein, required
GL..L[IFM][VRN]
for mannosylation of inositolphosphorylceramide
54 L..L.L..L
and
Leucine
for growth
rich at
repeat
high calcium
common
concentrations
in protein protein interactions. They are normally 24 amino acids long
0.006
8
LTE1: Putative GDP/GTP exchange factor required for
KL[IP]D[EWG]
mitotic exit at low temperatures;
54 acts
LPDEL
as a guanine nucleotide
Motif inexchange
CBP forfactor
interaction
(GEF) for
with
Tem1p,
PPARg-LBD
which is a(secondary
key regulatorsite)
of mitotic exit; physically associates with Ras2p-GTP
0.006
8
binding
Q..[QVT]Q
53 [ST]Q
ATM kinase phosphorylation site
RRM_1
1.E-03
-3.2
protein binding (1e-58)
0.011
10
RNA processing
H[RHL].G[RCL]T
53
Y
DEAD
1.E-19
-2
Y
0.010
10
KL.[SEI]
53 NKLY
LIM3 domain in enigma binds to this site in Ret
BRCT
1.E-05
-1.8
0.011
10
PUF6: Pumilio-homology domain protein that binds KK.[SVR][KGE]
ASH1 mRNA at PUF consensus
53sequences
RKK.[ST]
in the 3' UTR ZIP
and kinase
represses
phosphorylation
its translation, resulting
motif in proper asymmetric
Brix localization
1.E-02
of ASH1 mRNA
-1.4
0.010
10
L..[PNM]S
53
Y
Zn_clus
1.E-05
-1.2
0.011
10
DE[AVI][DHR]
53 YDE[PDV]
Y must Helicase_C
-1.2
Y
0.011
10
L[YIV]..P[GPT]
53 [PV]..P
LIG_SH3_3LIG_SH3_3
Helicase_C
1.E-12
-1.2
Y
0.012
10
DV[AVE]A[RFK]
53 subunit, has similarity to E. coli L23 and rat L23a ribosomal
Y proteins; binds
DEAD
to 26S rRNA via
1.E-04
-1.2
RNA
motif helicase activity (1e-04)
0.006
9
Q[QNH]Q
53
zf-C2H2
1.E-09
-0.6
0.011
10
[SE]D..[GPE]TL
53 thatPTL
controls growth in Motif
response
in Fos
to nutrients
for proteosome
by regulating
degredation
translation,
Cation_ATPase_N
transcription, ribosome1.E-02
-0.4 transport
ATPase
and autophagy;
activity, coupled
involved into
meiosis
transmembrane movement of ions, phosphorylative
0.006
mechanism
7
(0.01)
N[SGT].[STN]S
53
PH
1.E-02
-0.3
Y
0.011
10
Q[ITW][LHG]R
53cytoplasmic
[AG]Rvesicles; essential
Protease
for post-Golgi
matriptase
vesicle
protease
transport
site
Pkinase
1.E-13
0.5
Y
0.008
10
I..[VIL]V
53double null mutant exhibits enhanced synthesis of repressible acid phosphatase
MFS_1
at high inorganic
1.E-08
phosphate concentrations
1.6
0.010
10
MPP10: Component of the SSU processome, which [IMP][KH].WD
53 PWDLW
interacts with and
controls the stability of Imp3p and Imp4p, essential
WD40
1.E-07
to human Mpp10p
1.9
0.006
9
CDC15: Protein kinase of the Mitotic Exit Network thatHP.[IV][VIC]
53 bodies
HPQ
at late anaphase;Biotin
promotes
binding
mitotic
motif
exit in
by streptavidin
directly switching on thePkinase
1.E-14
3.2
0.006
10
RLP7: Nucleolar protein with similarity to large ribosomal
GK[TQG][LAF]A
subunit L7 proteins; constituent
53 of 66S pre-ribosomal particles; plays an essential role in processing of DEAD
precursors to the large
1.E-05
ribosomal subunit
3.3 RNAs
Y
0.006
9
GUS1: Glutamyl-tRNA synthetase (GluRS), forms a[VSM]D.W[SAR]
Pkinase
of both tRNA1.E-18
synthetases and
3.8
ensuresprotein
their correct
kinase
localization
activity
to the
(1e-17)
cytoplasm
0.007
8
RNA processing
[DY]EAD[RFQ]
53 YE
TPK-IIB/P38Syk kinase phosphorylation siteDEAD
(peptide screen)1.E-13
4.8
0.009
9
[LRM]AP[ECM]
53 P[TS]AP
LIG_PTAPLIG_PTAP
Pkinase
1.E-30
5.7
Y
0.011
10
[MRH][AKS]PE
53 FP.[PAILSK]P LIG_EVH1_ILIG_EVH1_I
Pkinase
1.E-33
5.8
Y
0.011
10
D[ILC]..[EQA]N
53
Pkinase
1.E-71
8.2
Y
0.011
10
[HFG]R.GR[TER]
53 [AG]R
Helicase_C
1.E-16
9.8
0.010
10
[HFG]R.GR[TER]
53 [AG]R
Helicase_C
1.E-16
9.9
0.010
10
endoplasmic reticulum
L..[LIV]F
53
endoplasmic reticulum (1e-22)
Y
0.012
10
[QRC]L..R[LE]P
groups
53
Y
9
endomembrane system
F[GQ].K[PHT]A
53
0.007
9
DE..[ELM]T[AP]
53
0.007
8
plasma membrane
S[SCV].[AFM]S
53 S[ST]
Y
0.011
10
protein targeting
FG.K[PEH][AN]
53 KEN
LIG_APCC_KENbox_2
0.006
8
L..D[ENT]
Cdc28p to promote
53the transition from G2 to M phase; accumulates during G2 andYM, then targeted via a destruction box motif for ubiquitin-mediated
cell cycle
degradation
0.009
10
HSP82: Hsp90 chaperone required for pheromone signalingL.G
and negative regulation
53of Hsf1p;
LFGdocks with Tom70p
Protease
for mitochondrial
Papain substrate,
preproteinadelivery;
prototype
promotes
cysteine
telomerase
proteinase
DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
Y
0.009
10
RAD53: Protein kinase, required for cell-cycle arrest in [ATR]S...D
DNA
a role
damage
in initiation
response,
of DNA replication
signal transduction (0.001)
Y
0.010
10
RAD53: Protein kinase, required for cell-cycle arrest[DES]E[DEK]E
activated
EEEYF
EGFR kinase
when
phosphorylation
interacting with hyperphosphorylated
site (peptide screen)
regulation
a role in initiation
of gene
of expression,
DNA replicationepigenetic (0.001)
Y
0.010
10
G[KIR]KV[TAK]
53 subunit,
G[KR][KR]
has similarity
Amidation
to E. coli L23
after
and
cleavage
rat L23a ribosomal
after Gly proteins;
(must bebinds
in secretory
to 26S rRNA
pathway)
via a conserved C-terminal cytosolic
motif
0.006
9
[LEM][LAV].KLS
nucleolus (1e-06)
Y
0.006
10
CBF5: Pseudouridine synthase catalytic subunit of EE..[KGP][DEK]
53 EED particles (snoRNPs),
Ankyrinacts
B C-terminal
on both large
motif
andthat
smallbinds
rRNAs
internal
and on Ankyrin
snRNA U2
repeats
nucleolus (1e-13)
0.010
10
AR..[ASH]K[EIK]
nucleolus
[AG]R
0.006
10
[DVF]I..F[DNG]D
53 thatDF.DF
controls growth in EF
response
hand to
innutrients
gamma-synergin
by regulating
binding
translation,
motiftranscription, ribosome biogenesis, nutrient transport
cellular
and autophagy;
morphogenesis
involved in
(0.01)
meiosis
0.006
10
BCK1: Mitogen-activated protein (MAP) kinase kinase
K[LFA]..G[SQE]K
kinase acting in the protein 53
kinase [LI][IVCAP]D.K[LIFY]E[FI]G
C signaling pathway,SAICAR_SYNTHETASE_2
which controls cell integrity; upon
PATTERN
activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.005
9
DBP8: Putative ATP-dependent RNA helicase of the[SMP]EV[DTP]A
DEAD-box family involved in 53
biogenesis
[ST]E
G protein-coupled
subunit
0.006
10
KEM1: Evolutionarily-conserved 5'-3' exonuclease [PKA]P.P[QKF]Q
component of cytoplasmic processing
53 (P)
P.Pbodies involved in
motif
mRNA
in interleukin
decay; plays5a receptor
role in microtubule-mediated
necessary for signaling
processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance
0.006
8
TUB2: Beta-tubulin; associates with alpha-tubulin (Tub1p
VQ..[TDP][TFW]
and Tub3p) to form tubulin
53dimer, which polymerizes to form microtubules
Y
0.007
10
ES..[DGR][ED]K
53 the
S..[ED]
U3 snoRNA that isCasein
involved
kinase
in processing
II substrate
of pre-18S
motifrRNA
0.006
10
YRA1: Nuclear protein that binds to RNA and to Mex67p,
ED[EKD].E
required for export of poly(A)+
53 mRNA
SEDEE
from the nucleus;
CKIImember
kinaseofphosphorylation
the REF (RNA and
site
export
(peptide
factor screen)
binding proteins) family; another family member,
rRNA
Yra2p,metabolism
can substitute (1e-05)
for Yra1p function
0.010
10
RSC3: Component of the RSC chromatin remodeling[FM]EV[LCM]
53 for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p
0.006
9
HMO1: Chromatin associated high mobility group (HMG)
[IQY]K..K[RMF]S
family member involved in
53genome
KRmaintenance; rDNA-binding
CLV_PCSK_PC1ET2_1
component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
0.005
9
NOP14: Nucleolar protein, forms a complex with Noc4p
L[KAP]V[LWI]K
that mediates maturation and
53 nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for small
processing
nucleolar
of pre-18S
ribonucleoprotein
rRNA
complex (1e-04)
0.005
9
L[NDA]K[LRV]A
53 nuclear
G[SA]LNK
export of 40S ribosomal
GDP-mannose
subunits;binding
also present
motifininthe
transporter
small subunit processome complex, which is required for rRNA
processing
processing
of pre-18S (1e-04)
rRNA
Y
0.005
8
MAK5: Essential nucleolar protein, putative DEAD-box
[TVA]E.[EVF]ED
53 EEDof M1 dsRNA virus;
Ankyrin
involved
B C-terminal
in biogenesis
motif
of that
largebinds
(60S) ribosomal
internal Ankyrin
subunitsrepeats
0.006
10
PRP45: Protein required for pre-mRNA splicing; associates
LE..S[IFL][SIR]
with the spliceosome and
53 interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
0.006
7
oshea_bud
S[SVI][STR]S
53 S[ST]
bud (1e-27)
0.010
10
PPH22: Catalytic subunit of protein phosphatase 2A,SP.[GD]R[LYN]
functionally redundant with Pph21p;
52 SP
methylated at C terminus;
ERK1,forms
ERK2
alternate
Kinasecomplexes
substratewith
motif
several Proteasome
regulatory subunits; involved
1.E-08
in signal transduction
-3.7
proteasome
and regulationcore
of mitosis
complex, alpha-subunit complex (sensu Eukaryota) (1e-10)
0.007
9
RNA processing
E[EVD].E[KDI]
52 SEDEE
CKII kinase phosphorylation site (peptide screen)
DEAD
1.E-07
-2.1
0.011
10
POB3: Subunit of the heterodimeric FACT complexK[ACQ].A[ERA]K
52 RNA Pol II transcription elongation through nucleosomes by destabilizing and
Histone
then reassembling
1.E-03
nucleosome-1.9
structure;establishment
interacts with DNAand/or
polymerase
maintenance
alpha (Pol1p)of chromatin architecture (0.001) 0.006
9
N.D[DST]
52
zf-C2H2
1.E-06
-1.5
Y
0.011
10
[RMS][GSW].DIP
52 subunit,
S.D has similarity
CAMKII
to E. coli
phosphorylation
L23 and rat L23a site
ribosomal proteins; binds
DEAD
to 26S rRNA via
1.E-07
-1.3
RNA
0.005
10
F.[FLY]L
52 YF.[FPLY]
SH2 ligand for PTPN6-N (Tyr must be phosphorylated)
ABC_tran
1.E-03
-1.2
0.011
10
EE[DIT]
52 EE[END]Y[MF][MF][MFIE][MF]
Insulin receptor kinase substrate motif
Zn_clus
1.E-05
-0.9
0.011
10
TUB1: Alpha-tubulin; associates with beta-tubulin (Tub2p)
L[LIG].[NAP]VL
to form tubulin dimer, which
52 polymerizes to form microtubules
HEAT
1.E-02
-0.7
0.005
8
RPF2: Essential protein involved in the processing of
E[EKY]..[EDG]E
of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizesHelicase_C
-0.7 of 66S
cytoplasm
pre-ribosomal
organization
0.009
10
[ND]N[VNI]EE
52 II transcription
Y[DE]N[IFV]
initiation and
SH2inligand
chromatin
for modification,
SYK-C (Tyrsimilar
must be
to histone
phosphorylated)
Bromodomain
H3
1.E-02
-0.6
Y
0.006
10
[KDQ]E[DNEQ]E
52 EEEYF
EGFR kinase phosphorylation site
Y (peptide screen)
HEAT
1.E-03
-0.5
nucleolus (1e-55)
Y
0.011
10
[KDQ]E[DNEQ]E
52 EEEYF
EGFR kinase phosphorylation site
Y (peptide screen)
HEAT
1.E-03
-0.4
nucleolus (1e-55)
Y
0.011
10
SIK1: Essential evolutionarily-conserved nucleolar protein
K[ETM][KVL]K
component of the box C/D
55 snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation;
WD40overexpression
1.E-02
causes spindle
1.7 orientation
nucleolus
defects(1e-28)
hydrolase activity
[WL]D..GQ[EDP]
55
D..G
motif that binds phosphate in GDP and GTP binding
Ras proteins1.E-34
MAK11: Protein involved in an early, nucleolar step [GEI]K[TWK]LA
55 essential for cell growth and replication of killer M1 dsRNA virus; contains
DEAD
1.E-02
repeats
yeast-376_GO-0019219
protein_40_YPL131W
yeast-939_GO-0051234
yeast-312_GO-0006414
protein_40_YNL031C
yeast-200_GO-0006519
yeast-413_GO-0005215
yeast-379_GO-0031975
yeast-379_GO-0031967
yeast-413_GO-0005215
yeast-1547_GO-0043283
yeast-752_GO-0016787
protein_40_YGL105W
yeast-341_GO-0045449
protein_40_YDR496C
protein_40_YER006W
protein_40_YML010W
protein_40_YLL008W
protein_40_YOL127W
yeast-468_GO-0051276
yeast-343_GO-0005198
yeast-234_GO-0006605
protein_40_YPR119W
protein_40_YPL209C
protein_40_YOR310C
protein_40_YOL120C
protein_40_YNL118C
protein_40_YNL110C
protein_40_YNL002C
protein_40_YMR049C
protein_40_YJL190C
protein_40_YHR152W
protein_40_YHR114W
protein_40_YGL135W
protein_40_YGL019W
protein_40_YDR450W
protein_40_YDR382W
protein_40_YDR145W
protein_40_YDL055C
protein_40_YDL014W
protein_40_YBR017C
oshea_mitochondrion
genetic_YLR262C
yeast-217_GO-0007046
protein_40_YPL093W
protein_40_YGL111W
yeast-262_GO-0031224
protein_40_YHR052W
protein_40_YDR496C
protein_40_YNL061W
yeast-215_GO-0007010
yeast-1433_GO-0006139
yeast-457_GO-0007001
yeast-413_GO-0005215
yeast-1062_GO-0016020
protein_40_YML085C
yeast-939_GO-0051234
protein_40_YPL126W
yeast-413_GO-0005215
protein_40_YBR031W
protein_40_YBR031W
protein_40_YGL207W
protein_40_YPL217Cs
protein_40_YGL207W
yeast-376_GO-0019219
yeast-256_GO-0016462
protein_40_YMR229C
yeast-504_GO-0006350
yeast-379_GO-0031975
yeast-379_GO-0031967
yeast-256_GO-0016462
yeast-213_GO-0009719
yeast-207_GO-0006974
protein_40_YPL153C
protein_40_YPL093W
protein_40_YMR047C
protein_40_YMR047C
protein_40_YLR293C
protein_40_YLL034C
protein_40_YLL011W
protein_40_YKL065C
protein_40_YJR145C
protein_40_YHR099W
protein_40_YGR252W
protein_40_YEL037C
protein_40_YDR382W
protein_40_YDL213C
protein_40_YDL148C
protein_40_YDL147W
protein_40_YDL055C
protein_40_YBR200W
protein_40_YBR198C
protein_40_YBR059C
genetic_YPL055C
genetic_YPL055C
protein_40_YPR103W
protein_40_YLR197W
yeast-410_GO-0007049
protein_40_YMR049C
protein_40_YJR145C
yeast-238_GO-0017111
protein_40_YHR052W
protein_40_YER006W
protein_40_YGR128C
protein_40_YGL112C
protein_40_YDR167W
yeast-468_GO-0051276
yeast-921_GO-0006810
protein_40_YLR180W
protein_40_YML010W
protein_40_YBL002W
protein_40_YPL211W
protein_40_YLL045C
protein_40_YNL186W
protein_40_YPL211W
protein_40_YHR052W
yeast-630_GO-0051244
yeast-631_GO-0050794
yeast-1062_GO-0016020
protein_40_YPL153C
protein_40_YPL153C
protein_40_YOR016C
protein_40_YNL308C
protein_40_YNL298W
protein_40_YNL298W
protein_40_YMR186W
protein_40_YMR047C
protein_40_YML069W
protein_40_YLR423C
protein_40_YLR180W
protein_40_YLR175W
protein_40_YKR081C
protein_40_YKR001C
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
N..D[DET]
acid metabolism
52 NK.D
Motif for specificity of guanine in purine binding
PUF
proteins
1.E-02
-0.2
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
0.011 (1e-20)
10
1.E-02
0.3
0.010
10
LV..[LVF][ILMV]
52
MFS_1
1.E-05
0.4
0.011
10
A[ES]..KE[EH]
52 KEN
LIG_APCC_KENbox_2
Ribosomal_60s
1.E-08
0.9
0.007
8
HHT2: One of two identical histone H3 proteins (seeLE..[GRA][NI]A
52 for chromatin assembly, involved in heterochromatin-mediated telomericHistone
1.6
methylation,
establishment
and mitotic
and/or
phosphorylation
maintenance of chromatin architecture (0.01) 0.006
10
[GAC]L...G
52
PALP
1.E-05
1.7
amino acid and derivative metabolism (1e-13)
0.011
10
EG..[AGS]L[YFW]
52
Mito_carr
1.E-31
1.8
Y
0.010
10
envelope
[DKP][VTC].KTR
52
Mito_carr
1.E-23
1.9
envelope (1e-17)
0.011
10
organelle envelope
[DKP][VTC].KTR
52
Mito_carr
1.E-23
2
envelope (1e-17)
0.011
10
[LFI]D..K[TVF]R
52
Y
Mito_carr
1.E-46
2.2
Y
0.012
10
V.[ELI]K
52 P.V.L
Shadow-Chromo domain binding motif
Pkinase
1.E-05
2.2
0.011
10
hydrolase activity
G[KYI]..L[LAD]
52 Y..L
Motif for down regulation of the CD46
Y
receptor
ABC_tran
1.E-06
2.5
hydrolase activity, acting on acid anhydrides (1e-43)
Y
0.011
10
[LIA]K..N
synthetases (Mes1p
the cytoplasm; 2.9
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-19)
Y
0.009
10
KR...[KGE]
52 KR
CLV_PCSK_PC1ET2_1
Zn_clus
1.E-08
3.1
Y
0.011
10
PUF6: Pumilio-homology domain protein that binds[GVS]K.AA[FSG]
52sequences in the 3' UTR and represses its translation, resulting in proper asymmetric
DEAD localization
1.E-03
of ASH1 mRNA
3.1
nucleolus (1e-07)
0.006
8
NUG1: GTPase that associates with nuclear 60S pre-ribosomes,
DEA[DRA][RLS]
required for export
52of 60S ribosomal subunits from the nucleus
DEAD
1.E-02
3.2
0.005
8
SPT5: Protein that forms a complex with Spt4p and[SIK]P..E[LCY]A
52 [ST]P
of transcription elongation;
LIG_WW_4LIG_WW_4
Spt4p-Spt5p complex also plays a role in DEAD
pre-mRNA processing
1.E-05
3.4
0.006
8
[TRV]G.GK[TIY]
including
[SAG]GGTG[SA]G
TUBULINsubunits;
PATTERN
constituent of 66S pre-ribosomal
DEAD
particles
1.E-04
3.4
0.006
10
[PTD][TES]REL
52 subunit,
RE..E has similarity
Iron
to E.
binding
coli L23motif
and rat
in ferritin
L23a ribosomal
L-chainproteins;
and yeast
binds
DEAD
Iron
to 26S
transport
rRNA via
protein
1.E-09
4.1
RNA
0.005
10
chromosome organization and biogenesis
D[EDG]..E[DNEQ]
52 Q[MLVI]DG..[DE]
CLV_TASPASE1
0.011
10
structural molecule activity
FG.[KR][PGH]A
52 G[KR][KR]
Amidation after cleavage after Gly (must be in secretory pathway)
0.007
9
protein targeting
[AGE]FSFG
52 F.F
WASP Homology 1 binding motif
0.006
10
I..[QKC]R
Cdc28p to promote
52the transition
[KR]R from G2 to M
CLV_PCSK_KEX2_1
phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated
cell cycle
degradation
0.009
10
IPL1: Aurora kinase involved in regulating kinetochore-microtubule
[EDT]K..[KNS]AA
attachments; helps
52 maintain
K..[ST]
condensed chromosomes
PKA kinaseduring
substrate
anaphase
motifand early telophase; associates with Sli15p, which promotes Ipl1p association with mitotic spindle
Y
0.006
10
NOP58: Protein involved in pre-rRNA processing, LE..D[EQA][EQD]
18S rRNA synthesis, and snoRNA
52synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
0.006
9
KK[VDQ][EVF]D
52 and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target
cytoplasm
for Rnt1p cleavage
organization
leading to
and
degradation
biogenesis (0.001)
0.006
10
L[SDT]..E[IEF]S
52 [ST]..E
the 5' cap structureCasien
from mRNAs
kinase
prior
II consensus
phosphorylation
member of site
the Nudix hydrolase family
0.006
7
NOP15: Constituent of 66S pre-ribosomal particles,
[ELG]E..E[ENG]E
52 biogenesis; localizes to both nucleolus and cytoplasm
0.009
10
S[DSW].E[ESL]E
52 QPS..E
of 66S pre-ribosomalPhosphorylation
particles; plays anmotif
essential
in alpha
role in3A,
processing
Y alpha 6A,
of precursors
alpha 7AtoIntegrin
the large
tails
ribosomal subunit RNAs
nucleolus (1e-13)
0.007
10
ERB1: Protein required for maturation of the 25S and
AR..[ASP]K[EIV]
5.8S ribosomal RNAs; constituent
52 of[AG]R
66S pre-ribosomalProtease
particles; homologous
matriptasetoprotease
mammalian
siteBop1
nucleolus (0.001)
0.005
9
RPS22A: Protein component of the small (40S) ribosomal
AE..[AS]A[ENL]
subunit; nearly identical52
to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
ribonucleoprotein complex (0.001)
0.006
10
SPO12: Nucleolar protein of unknown function, positive
D[QC].R[DSY]
regulator of mitotic exit; involved
52 in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis
0.005
8
BZZ1: SH3 domain protein implicated in the regulation
[LF]R[TQM]LG
52to recruit
R.Lactin polymerization
Cyclin
machinery
A motifthrough
that binds
its SH3
cdk2
domains,
complexes
colocalizes with cortical actin patches and Las17p, interacts with type I myosins
0.006
9
RPL1B: N-terminally acetylated protein component [KAP]GK[KLT]V
52 nearly
G[KR][KR]
identical to Rpl1Ap
Amidation
and has
after
similarity
cleavage
to E. coli
after
L1Gly
and (must
rat L10a
beribosomal
in secretory
proteins;
pathway)
rpl1a rpl1b double null mutation
cytosolic
is lethal
0.005
10
CKB1: Beta regulatory subunit of casein kinase 2, [KGR]P..K[VHR]L
a Ser/Thr protein kinase with roles
52 in cell
KP..[QK]
LIG_SH3_4LIG_SH3_4
the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases
0.006
10
[RPD]R.[AY]R
to Rps18Bp
[AG]R
and has similarity
Protease
to E. coli
matriptase
S13 and ratprotease
S18 ribosomal
site proteins
0.006
9
RPP2B: Ribosomal protein P2 beta, a component KK..[FQG]T[KNG]
of the ribosomal stalk, which is involved
52
in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap
cytosolic
and Rpp1Bp)
ribosome
in the(sensu
cytoplasm
Eukaryota) (0.01)
0.006
8
SVL[PFY][KNG]
52 LPKY
II transcription initiation
WWand
motif
in chromatin
(non-conventional
modification,) similar
in spt23
to histone
for binding
H2A to WW domain of RSP5p, also for NEDD4 WW domain
Y
0.005
8
[FAR]D..P[EQ]D
guanyltransferase),
52 synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
0.006
9
[SEA]D.D[SEN]
52 is required
D.D for processing
Ribose
of pre-18S
moiety
rRNA;
of UDP
has similarity
and manganese
to mammalian
binding
fibrillarin
site in glucuronyl transferase
nucleolus (1e-22)
0.010
10
KAP104: Transportin, cytosolic karyopherin beta 2 involved
LF.N[NAC][NKF]
in delivery of heterogeneous
52 nuclear
LFG ribonucleoproteins
Protease
to the
Papain
nucleoplasm,
substrate,
bindsarg-nuclear
prototype
localization
cysteine signals
proteinase
on Nab2p and Hrp1p, plays a role
tRNA
in cell-cycle
splicing
progression
(0.01)
0.006
8
[FLT]G..N[NT]N
52
0.006
10
oshea_mitochondrion
R[FYL].[SWT]T
52
Y
mitochondrial part (1e-16)
Y
0.010
10
YPT6: GTPase, Ras-like GTP binding protein involved
EN..[KDL][EAQ]
in the secretory pathway, required
52 for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity
nucleoplasm
to the human
part
GTPase,
(1e-05)
Rab6
0.009
10
ribosome biogenesis
DV.[AS]R[GR]
51 [AG]R
DEAD
1.E-14
-1.9
0.007
10
RG.[DAQ][IL]P
51 RGD
and is required for LIG_RGDLIG_RGD
60S ribosomal subunit biogenesis; constituent of 66S
DEAD
1.E-08 member
-1.3
of the ODN
ATP-dependent
family of nucleolar
RNA
G-proteins
0.006
10
NSA1: Constituent of 66S pre-ribosomal particles, involved
HR.[GLE][RDC]
in 60S ribosomal subunit
51biogenesis
R.L
Cyclin A motif that binds cdk2 complexes DEAD
1.E-06
-1.3
Y
0.006
9
F.[FLY]L
51 YF.[FPLY]
ABC_tran
1.E-03
-1.2
0.011
10
[TR]G.[GMS]KT
Helicase_C
particles
1.E-11
-1
0.007
10
PUF6: Pumilio-homology domain protein that bindsD[VML]AA[RLT]
51sequences in the 3' UTR and represses its translation, resulting in proper asymmetric
DEAD localization
1.E-02
of ASH1 mRNA
-1
0.006
10
[TRM]G.GK[TI]
51 of[SAG]GGTG[SA]G
27S pre-rRNA andTUBULIN
large ribosomal
PATTERN
subunit biogenesis; localized to
Helicase_C
the nucleolus; constituent
1.E-10
-0.8
ATP-dependent
particles
0.006
9
cytoskeleton organization and biogenesis
PPP[LRH][PRQ]
51 [DE]FPPP
EVH binding motif of Mena
SH3_1
1.E-02
-0.6
cytoskeleton organization and biogenesis (1e-15)
0.009
10
QQ...[QKH]
51
zf-C2H2
1.E-06
-0.1
Y
0.011
10
chromosome organization and biogenesis (sensu Eukaryota)
KR[KPM]
51 KR
CLV_PCSK_PC1ET2_1
Bromodomain
1.E-02
0.2
Y
(1e-19) 0.011
10
[LAC]L..A[FVA]
51
Mito_carr
1.E-08
0.3
Y
0.011
10
membrane
F..Y
51
Y
Mito_carr
1.E-08
0.4
Y
0.011
10
IV..[LPF][LRA]S
HEAT
1.E-04
0.5
protein carrier activity (0.001)
0.005
7
establishment of localization
I..[LAI]I
51
MFS_1
1.E-06
0.6
establishment of cellular localization (1e-10)
Y
0.010
10
NAN1: U3 snoRNP protein, component of the small LL[ACF][VIA]G
(ribosomal) subunit (SSU) processosome
51 FIGQY
containing U3 snoRNA;
Ankryn G
required
binding
for motif
the biogenesis
in neurofascin
of18S rRNA WD40
1.E-04
0.7
nucleolus (1e-07)
Y
0.006
9
VV.[LVF][LVY]
51
MFS_1
1.E-03
1.5
Y
0.011
10
RPL4A: N-terminally acetylated protein component[LQE]V..EA[DKT]
51 nearly
IEADidentical to Rpl4Bp
Protease
and has
Caspase
similarity10
to E. coli L4 and rat L4 ribosomal
DEADproteins 1.E-02
2.6
0.005
10
RPL4A: N-terminally acetylated protein component of[PFS]T.E[LF]A
51 nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal
DEADproteins 1.E-07
3.2
Y
0.005
10
SPT16: Subunit of the heterodimeric FACT complexR[DRI].K[PIL]E
(Spt16p-Pob3p), facilitates RNA
51Polymerase II transcription elongation through nucleosomes by destabilizing
Pkinase
and then reassembling
1.E-07
nucleosome
3.4structure
Y
0.006
10
BMS1: Essential conserved nucleolar GTP-binding E[YR]..GG[SFD]
protein required for synthesis of
5140S ribosomal
G[FL]PGER..G
subunits and
LIG_IBS_1LIG_IBS_1
for processing of the 35S pre-rRNA at sites A0,Pkinase
A1, and A2; interacts
1.E-03
with Rcl1p, has
3.6
similarity
protein
to Tsr1pserine/threonine kinase activity (0.001)
0.006
9
SPT16: Subunit of the heterodimeric FACT complex (Spt16p-Pob3p),
W[SA].G[ITC]facilitates RNA
Pkinase
1.E-10
nucleosome
3.7structure
0.007
10
K[KPR].K
acid metabolism
51 K[KR].[KR]
Zn_clus
1.E-06
3.8
0.011 (1e-26)
10
KT.[LTA][LAI]
51 DKTGT[LIVM][TI]
ATPASE_E1_E2 PATTERN
Y
AAA
1.E-10
3.8
Y
0.011
10
RRP5: Protein required for the synthesis of both 18SR[DIE].K[PTL]
51 isMR[DE][IL]
TUBULIN_B_AUTOREG
of 18S rRNA and N-terminal
PATTERN
region is required
Pkinase
component of small
3.9 ribosomal
protein
subunit
kinase
(SSU)
activity
processosome
(1e-15)
0.010
10
transcription
C..C[RGE]
51 C..C
Y
proteins
Zn_clus
1.E-24
19.8
Y
0.011
10
envelope
[SHW][GMF]GLF
51
envelope (1e-08)
0.008
9
organelle envelope
[SHW][GMF]GLF
51
envelope (1e-08)
0.008
9
EN.[LP]K[DT]
51
0.007
9
response to endogenous stimulus
K[KRI][RVP]K
51 KR
CLV_PCSK_PC1ET2_1
response to endogenous stimulus (1e-91)
Y
0.011
10
response to DNA damage stimulus
K[RIK][VRP]K
51 KR
CLV_PCSK_PC1ET2_1
response to DNA damage stimulus (1e-91)
Y
0.011
10
RAD53: Protein kinase, required for cell-cycle arrestG[TQN][TPI]TT
activated
YTT[ILM]
Syk N-terminal
whenSH2
interacting
domain
withbinding
hyperphosphorylated
motif
0.005
10
DI..E[IA][ALG]
51
and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN
cytoplasm
family of nucleolar
organization
G-proteins
0.006
10
A[ALI]K[PQV]S
of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p;mRNA
homologous
export
to Nup100p
from nucleus (1e-07)
0.005
10
G[GN].FG[NSF]
of the LFG
Protease
GLFG
Papain
motif that
substrate,
interacts a
with
prototype
mRNA export
cysteine
factorproteinase
Mex67p and with karyopherin Kap95p;snRNP
homologous
protein
to Nup100p
Y
0.005
9
L[EIG]LS[ANQ]
51 of nuclear
LSQEorganization,ATM
RNA processing
kinase substrate
and transport;
motif regulated by Prp20p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog
0.005
8
RIX7: Putative ATPase of the AAA family, required E[DKA].E[DNA]E
for export of pre-ribosomal large51
subunits
SEDEE
from the nucleus;CKII
distributed
kinasebetween
phosphorylation
the nucleolus,
sitenucleoplasm,
(peptide screen)
and nuclear periphery depending on growth conditions
nucleolus (1e-07)
0.007
10
SOF1: Essential protein required for biogenesis of 40S
[TVI]D.SK[RYI]
51 similarity
KR to the beta subunit
CLV_PCSK_PC1ET2_1
of trimeric G-proteins and the splicing factor Prp4p
0.005
10
YET1: Endoplasmic reticulum transmembrane protein;
V[SGL].L[VWI]L
may interact with ribosomes,
51based on co-purification experiments; homolog of human BAP31 protein
0.006
10
[KGR]E..E[KDI]T
subunit; mutation affects 51
20S pre-rRNA
RE..E processing; identical
Iron binding
to Rps4Bp
motifand
in ferritin
has similarity
L-chain
to rat
andS4yeast
ribosomal
Iron protein
transport protein
Y
0.005
10
TRA1: Subunit of SAGA and NuA4 histone acetyltransferase
VLE[YD][LV]
complexes; interacts 51
with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc
establishment
mediated oncogenic
and/or transformation
8
GCN5: Histone acetyltransferase, acetylates N-terminal
NN.[TEP][NIG]T
51 H3; N.[TS]
N-linked
ADA and
glycosylation
SAGA histonesite
acetyltransferase complexes; founding member of the Gcn5p-relatedSLIK
N-acetyltransferase
(SAGA-like)superfamily
complex (0.01)
0.005
8
RAD23: Protein with ubiquitin-like N terminus, recognizes
K[TAY].[DQA]LL
and binds damaged DNA
51(with Rad4p)
DLL during nucleotide
Binding
excision
motifrepair;
for clathrin
regulates
heavy
Rad4p
chain
levels,
earsubunit of Nuclear Excision Repair Factor 2 (NEF2);
proteasome
homolog of human
complex
HR23A
(sensu
and HR23B
Eukaryota)
proteins (1e-05)
0.005
8
RPP2B: Ribosomal protein P2 beta, a component of
[KLA]G.KV[TVG]
the ribosomal stalk, which is involved
51
in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap
cytosolic
and Rpp1Bp)
ribosome
in the(sensu
cytoplasm
Eukaryota) (1e-06)
0.006
10
KL[DVW][SKY]F
51RNANKLY
LIM3and
domain
has similarity
in enigma
to hydrophilins;
binds to this
NOP6
sitemay
in Ret
be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.005
10
[LYD]Q[ECT]EE
51 nuclear
EEEYF
EGFR kinase
subunits;
phosphorylation
also present in the
sitesmall
(peptide
subunitscreen)
processome complex, which is required for cytoplasm
processing of organization
pre-18S rRNA and biogenesis (0.001)
0.006
10
RPN5: Essential, non-ATPase regulatory subunit of
KG..L[YQN][GSV]
the 26S proteasome lid, similar
51
to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p
0.006
8
[QAD]E..[EAK]A
guanyltransferase),
51 synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell walltranslation
structure
(0.01)
Y
0.010
10
BEM1: Protein containing SH3-domains, involved inK[SRG]A[SK]S
establishing cell polarity and morphogenesis;
51 KR
functions asCLV_PCSK_PC1ET2_1
a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
incipient bud site (0.001)
0.006
9
[EVM]DE[DNV]E
51 II transcription
S[DE][DE]E
initiation and
BARD1
in chromatin
BRCT modification
domain binding motif
transcription factor complex (1e-13)
0.006
9
AKL1: Ser-Thr protein kinase, member (with Ark1pQQQ[PDK][QAP]
51 involved in endocytosis and actin cytoskeleton organization
endocytosis (1e-04)
0.006
9
LGE1: Protein of unknown function; null mutant forms abnormally
D[NLQ].N
large cells, and homozygous
51
diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
Y
(1e-16) 0.009
10
L..E[LEF]
51 S[LW]LD[DE]EL[LM]
diploid null mutant
TRG_LysEnd_GGAAcLL_2
displays delayed premeiotic DNAYsynthesis and reduced efficiency of meiotic nuclear division
Y
(1e-21) 0.009
10
PRE2: Beta 5 subunit of the 20S proteasome, responsible
S[PG].G[RNK]L
for the chymotryptic activity
50 of the
SG.G
proteasome
site
Proteasome
1.E-08
-3.9
proteasome core complex, alpha-subunit complex (sensu Eukaryota) (1e-10)
0.006
9
E...[ELP]E
50 snoRNP complexes that direct 2'-O-methylation of pre-rRNA during
Y
its maturation;
WD40overexpression
1.E-05
causes spindle
-2.2orientation
nucleolus
defects(1e-43)
0.009
10
cell cycle
K[KRL]..[TPI]S
50 K[KR].[KR]
Pkinase
1.E-02
-1.3
cell cycle (1e-10)
0.010
10
ERB1: Protein required for maturation of the 25S and 5.8S
K[KSV]K
ribosomal RNAs; constituent
50 ofP.[ST]PKK.KK
66S pre-ribosomalCdc2
particles;
likehomologous
protein kinase
to mammalian
substrateBop1
motif
Brix
1.E-03
-1.3
0.009
10
G[LQN]DIP
20S pre-rRNA processing; identical to Rps4Bp and has similarityYto rat S4 ribosomal
DEADprotein
1.E-02
-1.2
ribosome biogenesis (0.01)
Y
0.006
9
[LVD]I.[DFN]EA
50
Helicase_C
1.E-05
-0.8
Y
0.008
10
L[DGV].A[DLI]R
Helicase_C
particles
1.E-03
-0.8
0.006
9
[TRK]G.G[KNF]T
required for export
50of 60S
[SAG]GGTG[SA]G
ribosomal subunits
TUBULIN
from the nucleus
PATTERN
Y
Helicase_C
1.E-05
-0.7
0.006
7
UTP8: Nucleolar protein required for export of tRNAs[LQR]LA[VI]G
1.E-06
of pre-18S
-0.6
rRNA snoRNA binding (1e-07)
Y
0.006
10
NN[VNL][ES]E
involved in transcription initiation
50 [ST]E
of RNA polymerase G
II and
protein-coupled
in chromatin modification,
receptor kinase
similar
Y 1to substrate
histone
Bromodomain
H4 motif
1.E-02
-0.6
G1-specific transcription in mitotic cell cycle (1e-08)
0.005
10
[NV]N[VNL]EE
50 II Y[IV]N[ILV]
transcription initiation
SH2
andligand
in chromatin
for Grb2
modification
(Tyr must be
Y phosphorylated)
Bromodomain
1.E-02
-0.6
Y
0.006
10
K[KRN][RPV]K
50 KR
CLV_PCSK_PC1ET2_1
Y
Bromodomain
1.E-04
-0.2
0.011
10
transport
I..[LAI]I
50
MFS_1
1.E-07
0.3
intracellular transport (1e-10)
Y
0.010
10
SAM1: S-adenosylmethionine synthetase, catalyzes transfer
AR.[ADG]
of the adenosyl group50
of ATP[AG]R
to the sulfur atom of
Protease
methionine;
matriptase
one of twoprotease
differentially
siteregulated isozymes
GATase(Sam1p and1.E-02
Sam2p)
1.2
Y
0.010
10
SPT5: Protein that forms a complex with Spt4p and[KHL]K..VV[DIS]
50
of transcription elongation; Spt4p-Spt5p complex also plays a role in DEAD
pre-mRNA processing
1.E-02
1.3
Y
0.006
9
L[ED]..GN[ALG]
50 D..G
motif that function;
binds phosphate
Rad6p-Bre1p-Lge1p
in GDP
Y and
mediated
GTPHistone
ubiquitination
binding proteins
regulates
1.E-04
transcriptional
1.5 activation, meiotic DSB formation and H3 methylation
0.005
9
[DQH]EAD
of 66S [LIVMF][LIVMF]DEAD[RKEN].[LIVMFYGSTN]
DEAD_ATP_HELICASE
physically interacts with PATTERN
Nop8p and
Y the exosome
DEAD
3.6
0.005
8
RPL8B: Ribosomal protein L4 of the large (60S) ribosomal
IA[TR]P[GNI]
subunit, nearly identical50
to Rpl8Ap
[ST]P
and has similarity
LIG_WW_4LIG_WW_4
to rat L7a ribosomal protein; mutation
Y results in decreased
DEAD amounts1.E-05
of free 60S subunits
3.6
0.005
8
[MRE][ASK]PE
may regulate
FP.[PAILSK]P
silencing by acting
LIG_EVH1_ILIG_EVH1_I
on Sir4p; involved in posttranscriptionally regulating
Pkinase
Gap1p and 1.E-18
3.7
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-18)
Y
0.009
10
[TR]G.[GMS]KT
DEAD
3.9
0.005
10
CIC1: Essential protein that interacts with proteasomeIA[TR][PM]G
3.9
0.006
8
[ASV]C..C[RDV]
50 C..C
Zn_clus
1.E-27
19.7
0.011
10
[ASV]C..C[RDV]
50 C..C
Zn_clus
1.E-27
19.9
0.011
10
membrane
W..[AIW]I
50 W..[WFY]
AP1 binding site for endosomal trafficking
0.010
10
RAD53: Protein kinase, required for cell-cycle arrest in A...Q[PEY]
cellacortex
role in initiation
part (0.01)
of DNA replication
Y
0.009
10
TN[VMT]
to DNA damage; 50
activated
CP[ST]N[ILV]GT
GUANIDO_KINASE
when interacting
PATTERN
with hyperphosphorylated
Y
DNA
a role
integrity
in initiation
checkpoint
of DNA replication
(0.001)
Y
0.009
10
ERP4: Protein with similarity to Emp24p and Erv25p,
G[LMD]..L[IYC]V
member of the p24 family involved
50 in ER to Golgi transport
Y
0.006
10
KRI1: Essential nucleolar protein required for 40S ribosome
E[EQS].K[KHI]A
biogenesis; physically50
and functionally
KEESEK
interacts with
14-3-3
Krr1pgamma, epsilon nonphosphorylated binding motif in Ammodytoxin C, not confirmed
0.005
10
CLA4: Cdc42p activated signal transducing kinase [AKP]KK[RTQ]L
of the PAK (p21-activated kinase)
50 family,
KKKKKK[ST]
involved in septinTGF
ring assembly
beta receptor
and cytokinesis;
kinase substrate
directly
Y phosphorylates
motif
septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
0.005
9
CLA4: Cdc42p activated signal transducing kinaseSS..[KSQ][SRT]D
50 family,
S[ST]
involved in septinMDC1
ring assembly
BRCT and
domain
cytokinesis;
bindingdirectly
motif phosphorylates septins Cdc3p and Cdc10p; other yeastestablishment
PAK family members
of cell
are Ste20p
polarity
and(sensu
Skm1p Fungi) (0.01)
0.006
10
HSC82: Cytoplasmic chaperone of the Hsp90 family,[NEV]I[KTM]LS
redundant in function and nearly
50 identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
0.006
8
[DAK]I.[LEV]KA
of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p
Y
0.005
8
POB3: Subunit of the heterodimeric FACT complex (Spt16p-Pob3p),
[TC][KCM].AI
which facilitates
50 RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure;RNA
interacts
elongation
with DNA polymerase
from RNAalpha
polymerase
(Pol1p)
II promoter (0.001)
0.005
8
ATG17: Scaffold potein responsible for pre-autophagosomal
[RQY]RLS[ILW]
structure organization;
50interacts
R.Swith and is required
PKA
forkinase
activation
substrate
of Apg1pmotif
protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway
0.006
9
SAM1: S-adenosylmethionine synthetase, catalyzesA[GSF].[VLC]K
Y
0.010
10
CBF5: Pseudouridine synthase catalytic subunit of [KSF]K..K[KHN]
50 P.[ST]PKK.KK
particles (snoRNPs),
Cdc2 like
acts
protein
on bothkinase
large and
substrate
smallY
rRNAs
motifand on snRNA U2
nucleolus (1e-13)
0.009
10
RPF2: Essential protein involved in the processing [KHM]E[LAH]LS
of pre-rRNA and the assembly 50
of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
0.005
9
VPS1: Dynamin-like GTPase required for vacuolar ND..E[DRN][DTI]
sorting; also involved in actin cytoskeleton
50
organization, late Golgi-retention of some proteins, regulating
Y
peroxisome biogenesis
0.005
9
[NGK]K.K[NKP]
coli L18P.[ST]PKK.KK
Cdc2
proteins;
like protein
binds 5Skinase
rRNA and
substrate
is required
motif
for 60S
Helicase_C
subunit assembly
protein_40_YJR145C
protein_40_YJR022W
protein_40_YJL164C
protein_40_YJL033W
protein_40_YHR088W
protein_40_YHR066W
protein_40_YDR447C
protein_40_YDR145W
protein_40_YDR025W
protein_40_YDL147W
protein_40_YDL147W
protein_40_YDL043C
protein_40_YCR034W
protein_40_YCL059C
protein_40_YBR159W
protein_40_YBR009C
genetic_YNL153C
yeast-341_GO-0045449
protein_40_YPL153C
protein_40_YGL111W
yeast-410_GO-0007049
protein_40_YNL175C
protein_40_YLR002C
yeast-238_GO-0017111
yeast-1433_GO-0006139
yeast-304_GO-0019752
yeast-304_GO-0006082
protein_40_YGL105W
protein_40_YMR049C
protein_40_YDR060W
protein_40_YLR175W
yeast-240_GO-0006807
protein_40_YLR222C
matsuyama_ER
protein_40_YGL207W
yeast-320_GO-0006355
protein_40_YNL186W
yeast-217_GO-0007046
protein_40_YGL245W
protein_40_YGL245W
yeast-462_GO-0019222
yeast-335_GO-0016772
yeast-685_GO-0016740
yeast-631_GO-0050794
yeast-630_GO-0051244
yeast-238_GO-0017111
protein_40_YPR137W
protein_40_YPR119W
protein_40_YPL240C
protein_40_YOR310C
protein_40_YNL308C
protein_40_YMR236W
protein_40_YMR117C
protein_40_YMR117C
protein_40_YML069W
protein_40_YML010W
protein_40_YLR429W
protein_40_YLR347C
protein_40_YKL101W
protein_40_YJL109C
protein_40_YJL092W
protein_40_YJL033W
protein_40_YHR197W
protein_40_YHR052W
protein_40_YHR052W
protein_40_YFR037C
protein_40_YFR037C
protein_40_YFR034C
protein_40_YER082C
protein_40_YDR496C
protein_40_YDR448W
protein_40_YDR145W
protein_40_YDL083C
protein_40_YDL055C
protein_40_YDL031W
protein_40_YDL029W
protein_40_YCR031C
protein_40_YBR106W
protein_40_YAL032C
protein_40_YAL032C
oshea_vacuolar_membrane
oshea_cytoplasm
oshea_cell_periphery
matsuyama_Cytosol
matsuyama_Cytosol
genetic_YNL153C
genetic_YNL153C
yeast-1166_GO-0005488
protein_40_YGR252W
protein_40_YDL153C
yeast-661_GO-0050789
protein_40_YER006W
protein_40_YML010W
protein_40_YPL211W
protein_40_YKL014C
protein_40_YPL093W
protein_40_YPL043W
protein_40_YGR128C
yeast-752_GO-0016787
yeast-320_GO-0006355
protein_40_YNL002C
protein_40_YLR293C
protein_40_YPL004C
protein_40_YGL048C
protein_40_YDR328C
yeast-921_GO-0006810
yeast-413_GO-0005215
protein_40_YDR224C
protein_40_YJL081C
protein_40_YLL008W
protein_40_YLL008W
matsuyama_Cytosol
protein_40_YAR019C
yeast-648_GO-0050791
protein_40_YOL133W
yeast-322_GO-0005654
yeast-294_GO-0006366
yeast-261_GO-0016491
yeast-235_GO-0009653
yeast-235_GO-0000902
protein_40_YPR144C
protein_40_YPR119W
protein_40_YPL153C
protein_40_YPL042C
protein_40_YOR181W
protein_40_YOL013C
protein_40_YOL001W
protein_40_YNL209W
protein_40_YNL110C
protein_40_YMR242C
protein_40_YMR001C
protein_40_YML063W
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
RPS4A: Protein component of the small (40S) ribosomalA.K[AGF]
20S pre-rRNA
ARKGSLRQ
processing; identical
PKC alpha
to Rps4Bp
kinaseand
substrate
has similarity
motifto rat S4 ribosomal protein
(0.01)
Y
0.009
0.006
0.009
0.006
RPF1: Nucleolar protein involved in the assembly [EDQ]E..A[KQR]K
of the large ribosomal subunit; constituent
50 WAQKW
Motifparticles;
in Cet1contains
RNA triphosphosphatase
a sigma(70)-like motif,for
which
binding
is thought
to RNA
to bind
guanylyltransferase
RNA
Ceg1nucleolus (1e-07)
0.005
SSF1: Constituent of 66S pre-ribosomal particles, required
QR..K[ELY][ETD]
for ribosomal large subunit
50 maturation;
R..K functionallySH3
redundant
binding
withmotif
Ssf2p;
formember
GADS of
SH3
the Brix
recognizing
family
slp-76 motif (nonconventional)
0.006
RPS17B: Ribosomal protein 51 (rp51) of the small (40s)AR..[AR]
subunit; nearly identical to50
Rps17Ap
AR..R[RK]RSFRR
and has similarity
PKC
to rat
eta
S17
kinase
ribosomal
substrate
protein motif
Y
0.009
LN.S[LDI][SKQ]
50 N.[TS]
N-linked
and inglycosylation
chromatin modification,
site
similar to histone H2A
0.005
[RHL]R.[AGW]R
subunit; identical to Rps11Bp
50 and
[AG]R
has similarity to E.
Protease
coli S17 and
matriptase
rat S11 ribosomal
proteaseproteins
site
0.009
RPN5: Essential, non-ATPase regulatory subunit of the
L[QA].IN[DCS]
26S proteasome lid, similar
50
to mammalian p55 subunit and to another S. cerevisiae regulatory
Y subunit, Rpn7p
0.005
S[LEP][ATD]IS
50
to mammalian
SP
p55 subunitERK1,
and to ERK2
anotherKinase
S. cerevisiae
substrate
regulatory
motifsubunit, Rpn7p
0.006
PRP11: Subunit of the SF3a splicing factor complex,
L[RY]..K[NDK]S
required for spliceosome assembly
50 R..K
SH3 binding motif for GADS SH3
Y recognizing slp-76 motif (nonconventional)
0.005
FEN1: Fatty acid elongase, involved in sphingolipid biosynthesis;
FI..[IE]I[SGV]
acts on fatty acids
50of up to 24 carbons in length; mutations have regulatory effectsYon 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
0.006
KRR1: Essential nucleolar protein required for the synthesis
EE[SQK]S[GNH]
of 18S rRNA and for the
50 assembly
YEE[IV]
of 40S ribosomal
SH2
subunit
ligand group 1A, Src FGR SH2 domain (needs to be Tyr phosphorylated)
0.005
IFA38: Microsomal beta-keto-reductase; contains oleate
VS.[LVT][VWI]L
response element (ORE) sequence
50
in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
0.005
HHF1: One of two identical histone H4 proteins (see KD..[SM]K[IT]
also HHF2); core histone required
50 for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
0.005
GIM3: Subunit of the heterohexameric cochaperone prefoldin
KK[LTP]
complex which binds50
specifically
KKKKKK[ST]
to cytosolic chaperonin
TGF beta
andreceptor
transfers kinase
target proteins
substrate
to it motif
cell cycle (1e-12)
0.009
LP[SHP]
49 DLPPP
EVH1 binding motif
zf-C2H2
1.E-10
-2
0.010
RAD53: Protein kinase, required for cell-cycle arrest in [QKP]R..S
activated
R..SFF
Phosphorylase
when kinase
interacting
phosphorylation
site (peptide
PHRad9p;
screen)
also interacts
1.E-02with ARS1
-1.3and plays a role in initiation of DNA replication
0.009
[KRY]K..K[KER]
49biogenesis
KR
CLV_PCSK_PC1ET2_1
DEAD
1.E-04
-1.3
Y
0.009
cell cycle
D[SKY]I
49
Pkinase
1.E-05
-1.2
cell cycle (1e-21)
0.010
[EAV]K..[AKT]K
contains
K..[ST]
an RNA recognition
PKA
motifkinase
(RRM)substrate
and has similarity
motif to Nop12p, which DEAD
1.E-02of pre-18S
-1.2
rRNA cytoplasm organization and biogenesis (1e-16)
Y
0.009
R[GC]..I[PMY]
49precursors to mediate their intranuclear transport; also binds to
Y chromatin toDEAD
-1.2
nucleolus
(1e-05) initiation
Y
0.005
V[AIM]..[DCP]G
49
Y
ABC_tran
1.E-03
-0.6
Y
0.011
L.[LEI]D
49
Helicase_C
1.E-05
-0.5
0.010
[DEY]A..[AVR]G
49
GATase
1.E-02
0
0.011
[DEY]A..[AVR]G
49
GATase
1.E-02
0
0.011
S[DE]..LL[NCY]
synthetases (Mes1p
49 and
[DE]..LL
Gus1p), deliveringDi-Leu
tRNA toacidic
them, motif
stimulating
for receptor
catalysis,endocytosis
Yand ensuringPkinase
(recognized
their localization
by to
VHS
1.E-07
the cytoplasm;
domain ofalso
GGA
0 binds
proteins)
protein
quadruplex
kinase
nucleic
activity
acids (1e-06)
0.005
ED.[DIE][EDM]
49 ofYEDP
66S pre-ribosomalFyn
particles;
SH2 homologous
domain binding
to mammalian
motif Bop1
Brix
1.E-02
0.1
0.009
MAK21: Constituent of 66S pre-ribosomal particles, [AVK]K.A[KTR]
49 subunit biogenesis; involved in nuclear export of pre-ribosomes; required DEAD
0.1 of nucleolus
human CAATT-binding
(1e-18) protein
0.009
CBF5: Pseudouridine synthase catalytic subunit of box H/ACA
R.[GVA]K
small nucleolar ribonucleoprotein
49 GR.A particles (snoRNPs),
Protease
acts
tPA
onproteolytic
both large and
sitesmall rRNAsRibosomal_L7Ae
and on snRNA U2
1.E-02
0.2
0.009
nitrogen compound metabolism
GA.[IKV][VAI]
49
PALP
1.E-05
0.6
nitrogen compound metabolism (1e-62)
Y
0.010
[LQR]LA[VI]G
WD40
1.E-06
0.8
Y
0.006
matsuyama_ER
F[VFL].[GAI]I
49
MFS_1
1.E-03
1.5
endoplasmic reticulum membrane (1e-13)
Y
0.012
SPT16: Subunit of the heterodimeric FACT complex[RP]L.R[RGV]G
49Polymerase
RGG II transcription
Alternative
elongationintegrin
through binding
nucleosomes
site in
byFMDV
destabilizing
virus
Histone
1.E-06
nucleosome
1.6structure
regulation of transcription, DNA-dependent
KR...[KGE]
49 KR
CLV_PCSK_PC1ET2_1
Zn_clus
1.E-06
2.3
regulation of transcription, DNA-dependent (1e-19)
Y
0.010
I[LAV]..LG[TNF]
Pkinase
Gap1p and 1.E-08
2.4
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-08)
Y
0.005
ribosome biogenesis
PT.E[LH][AV]
49 P[ST]
DNA dependent Protein kinase substrate
Y
motif
DEAD
1.E-17
4.2
Y
0.007
K..DF[GHM]
Pkinase
of both tRNA1.E-16
synthetases and
4.3
ensuresprotein
their correct
kinase
localization
activity
to the
(1e-16)
cytoplasm
0.007
GUS1: Glutamyl-tRNA synthetase (GluRS), forms aW[SAG].G[CIV]
Pkinase
of both tRNA1.E-23
synthetases and
4.6
ensuresprotein
their correct
kinase
localization
activity
to the
(1e-23)
cytoplasm
0.008
K.[DPF]S
49 [NT]K.D
zf-C2H2
1.E-06
4.7
Y
0.010
[GNK][IVW]IH
groups
49
Pkinase
1.E-31
4.8
Y
(1e-39)0.011
[GKN][ICH]IH
49
Pkinase
1.E-24
4.9
Y
0.010
KR[KRE]
49 KR
CLV_PCSK_PC1ET2_1
Zn_clus
1.E-08
5.3
0.010
KR[KRE]
49 KR
CLV_PCSK_PC1ET2_1
Zn_clus
1.E-08
5.4
0.011
FL.[ESM][PRY]T
49
Y
0.006
[LMS]E.[DSE]DE
49 ofSEDEE
small ribosomal subunit
CKII kinase
(SSU) processosome;
phosphorylation
ortholog
site of
(peptide
the human
screen)
U3-55k protein
0.005
CLB2: B-type cyclin involved in cell cycle progression;
GK..[FEA][GIN]K
activates Cdc28p to promote
49the transition from G2 to M phase; accumulates during G2 andYM, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
0.006
HSP82: Hsp90 chaperone required for pheromone [FMI]G..[IGE]PK
signaling and negative regulation
49of Hsf1p;
GP docks with Tom70p
Protease
for mitochondrial
TTP cleavage
preprotein
site delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
0.007
L[KGA]..G[LTN]T
0.005
[GN]G.RG[RGN]
and functionally
RGG interacts with
Alternative
Krr1p
integrin binding site in
Y FMDV virus
small nucleolar ribonucleoprotein complex (0.001)
0.005
[ELP]FLE[RYA]
49 II transcription
F.E
initiation and
DNA
in binding
chromatin
motif
modification,
in MutSsimilar to histone H3
Y
0.005
SPC24: Component of the evolutionarily conserved[LVE]E.F[NQV]K
complex
EEEYF
EGFR kinase phosphorylation
involved in chromosome
site
Y (peptide
segregation,
screen)
spindle checkpoint activity and kinetochore clustering
0.005
SPC24: Component of the evolutionarily conserved [QLD]EL[QEK]
complex
[KRHQSA][DENQ]EL
ER_TARGET PATTERN
involved in chromosome segregation, spindle checkpoint activity and kinetochore
chromosome
clustering
segregation (0.001)
0.009
POB3: Subunit of the heterodimeric FACT complex[TDI][SAG]..GKK
49 RNAG[KR][KR]
Pol II transcription Amidation
elongation through
after cleavage
nucleosomes
afterbyGly
destabilizing
(must beand
in secretory
then reassembling
pathway)
nucleosome structure;DNA
interacts
binding
with DNA
(0.01)
polymerase alpha (Pol1p)
0.005
SPT5: Protein that forms a complex with Spt4p and[SPE]T..AN[IGH]
49 T..[SA]
FHA of KAPP
Spt4p-Spt5p
binding
complex
motif,also
Thrplays
Y
musta be
rolephosphorylated
in pre-mRNA processing
0.005
E[SFP].SE[PCR]
49 [ST]E
complex to regulate
G its
protein-coupled
activity; plays a role
receptor
in regulation
kinaseof1actin
substrate
patch assembly
motif
0.005
KAP95: Karyopherin beta, forms a dimeric complex with
FG[AW][NE]
Srp1p (Kap60p) that mediates
49 nuclear import of cargo proteins via a nuclear localization signal
Y (NLS), interacts with nucleoporins to guide transport across
nuclear
thepore
nuclear
(1e-09)
pore complex
0.006
HSL1: Nim1p-related protein kinase that regulates [LRT]A..[IMG]ET
the morphogenesis and septin checkpoints;
49
associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
0.005
UTP10: Nucleolar protein, component of the small [KRE]A.KT[KHQ]
subunit (SSU) processome containing
49 the U3 snoRNA that is involved in processing of pre-18S Y
rRNA
0.005
E.[LPF]D
for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
Y
0.009
HCA4: Putative nucleolar DEAD box RNA helicase; [NEC]I.S[SEL]T
high-copy number suppression49
of a U14
S[ST]
snoRNA processing
MDC1
mutant
BRCT
suggests
domain
an involvement
binding motif
in 18S rRNA synthesis
mRNA cleavage factor complex (1e-04)
0.005
RIX1: Essential component of the Rix1 complex (Rix1p,
[TFV][EN].EED
Ipi1p, Ipi3p) that is required
49for processing
EED of ITS2 sequences
Ankyrin from
B C-terminal
35S pre-rRNA;
motifRix1
thatcomplex
binds
Y internal
associates
Ankyrin
with Mdn1p
repeats
in pre-60S ribosomal particles
0.005
N[KNP].[KMI]KV
49 role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
nucleolus (0.001)
0.005
SEL[KGM][SMQ]
49 role
[ST]E
G protein-coupled
specificity; alsoreceptor
copurifies
kinase
with 66S
1 substrate
pre-ribosomal
motif
particles
Y
0.005
RSC8: Component of the RSC chromatin remodeling [LD][IM]..GP
complex; essential for viability
49and mitotic
GP growth; homolog
Protease
of SWI/SNF
TTP subunit
cleavage
Swi3p,
sitebut unlike Swi3p, does not activate transcription of reporters
0.005
I[DQN]..KD[TPA]
49and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.005
G[FTG]G[GVE]R
49 GGRGG
with Pho2p to the
Arginine
PHO5 methyl
promoter;
transferease
function is regulated
substrate
by phosphorylation
motif (PRMT1)at multiple sites and by phosphate availability
Y
0.005
GL[RAN][IK]G
49and has similarity to E. coli L2 and rat L8 ribosomal proteins
0.005
SK.[KSC][NQF]I
49 the
KRKQISVR
U3 snoRNA that isPhosphorylase
involved in processing
kinaseofsubstrate
pre-18S rRNA
motif
0.005
PUF6: Pumilio-homology domain protein that bindsDE.[EMT]I[EYW]
49sequences
IY in the 3' UTR cFGR
and represses
and Csk
its kinase
translation,
phosphorylation
resulting in proper
siteasymmetric
(peptide screen)
localization of ASH1 mRNA
nucleolus (1e-07)
0.005
ADA2: Transcription coactivator, component of the ADA
[YWM][DW]DV
and SAGA transcriptional 49
adaptor/HAT
Y[DQ]DV
(histone acetyltransferase)
SH2 ligand complexes
for Blnk (Tyr must beYphosphorylated)
0.005
QK[KDS][RV]K
49
II transcription initiation and in chromatin modification, similar to histone H2A
0.006
[RKV]V.RR
49 and
[KR]R
CLV_PCSK_KEX2_1
coli S9 and rat S16 ribosomal proteins
0.006
[TYQ]K..EE[IAS]
guanyltransferase),
49 synthesizes
YEEI GDP-mannose
SH2 from
ligand
GTP
group
and mannose-1-phosphate
1A (Src,Fyn,Lck) (phospho-peptide)
Y
0.005
DBP10: Putative ATP-dependent RNA helicase of the
K[RKD]..[VEK]E
DEAD-box protein family, constituent
49 K[KR].[KR]
Nuclear
particles;
localization
essential protein
motif involved in ribosome biogenesis
0.009
ARP2: Essential component of the Arp2/3 complex,[AVW]L.[LRG]SD
which is a highly conserved actin
49 nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
Y
0.006
RPS14A: Ribosomal protein 59 of the small subunit,
AR..A[KNM][KVS]
required for ribosome assembly
49and [AG]R
20S pre-rRNA processing;
Protease
mutations
matriptase
confer protease
cryptopleurine
site resistance; nearly identical to Rps14Bp and similar to E.cytosolic
coli S11 andribosome
rat S14 ribosomal
(sensuproteins
Eukaryota) (1e-04)
0.005
[FLI]F..[FLI]I
Y
0.009
[LNA]S..N[VSY]F
49 interacts with splicing factors Prp22p and Prp46p; orthologous
Y to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
Y
0.005
E.[TES]Q
49 interacts
[ST]Q
with splicing factors
ATM Prp22p
kinase and
phosphorylation
Prp46p; orthologous
site to human transcriptional coactivator SKIP and can activate
nuclear
transcription
mRNA
of asplicing,
reporter gene
via spliceosome (1e-11)
Y
0.009
S[ED]E[LTA]S
49 S[DE][DE][DE] Casein Kinase II substrate motif Y
vacuole (1e-06)
0.006
[SRM][AQF].GT
49 [SAG]GGTG[SA]G
TUBULIN PATTERN
Y
0.009
oshea_cytoplasm
P..[FVR]E
49 PP..F
LIG_EVH1_IILIG_EVH1_II
Y
0.009
[STH]SS[SAP]
49 S[ST]
Y
0.010
matsuyama_Cytosol
GK[VTY]
49 [GA]....GK[ST] Purine nucleotide triphosphate binding
Y
motif
purine nucleotide binding (1e-14)
Y
0.011
matsuyama_Cytosol
V[ESK]E
49 [ST]E
G protein-coupled receptor kinase 1 substrate motif
Y
0.012
GIM3: Subunit of the heterohexameric cochaperone[QE]Q..[QIW]QT
prefoldin complex which binds49
specifically to cytosolic chaperonin and transfers target proteins to it
Y
0.005
NS[VNK]
specifically to cytosolic chaperonin and transfers target proteinsY
to it
cell cycle (1e-16)
Y
0.009
binding
N.N[NAL]
48
RRM_1
1.E-09
-2.8
nucleic acid binding (1e-10)
0.010
[EQR]K..AS[KVQ]
48 H3; SQ
ATM
ADA
kinase
and SAGA
substrate
histonemotif
acetyltransferase complexes;
Histone
founding member
1.E-03
-1.9
establishment
N-acetyltransferase
and/or
superfamily
SAS10: Component of the small (ribosomal) subunitEDE[TEY][LYF]
48for pre-18S
SEDEE
rRNa processing;
CKIIessential
nucleolar protein that,
sitewhen
(peptide
overproduced,
screen)
Pkinase
disrupts silencing
1.E-04
-1.7
0.006
L.S[LDN]
48 WLNS
Lipid binding motif in C-terminus of Apolipoprotein
Zn_clus
AII
1.E-06
-1.6
0.010
[KVR]K..K[KEV]
required for export
48of 60S
P.[ST]PKK.KK
ribosomal subunits
Cdc2
from like
the nucleus
protein kinase substrate motif
DEAD
1.E-02
-1.6
0.009
SPT5: Protein that forms a complex with Spt4p and mediates
K[KAY]K[SYA]
both activation and inhibition
48 KKKKKK[ST]
TGF beta
Spt4p-Spt5p
receptor kinase
complexsubstrate
also plays motif
a role in DEAD
pre-mRNA processing
1.E-03
-1.4
Y
0.009
H[RM].G[RDC]
of 66S pre-ribosomal particles; physically interacts with Nop8p and
Y the exosome
DEAD
-1.3
0.005
[RYM]G.DI[PNK]
DEAD
-1.3 subunit
nucleolus (1e-06)
0.005
D[VMS]AA[RDA]
48
and is required for 60S ribosomal subunit biogenesis; constituent of 66S
DEAD
1.E-04 member
-1.2
of the ODN
RNA
family
helicase
of nucleolar
activity
G-proteins
(1e-04)
0.005
[PYD]S..[KER]KV
and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles;
RNA recognition-1motifs (RRMs)
Y
0.005
UTP8: Nucleolar protein required for export of tRNAs[WC]D..[STL]G
48 with
DH[YF]LGK[EQK]
the small subunit (SSU)
G6P_DEHYDROGENASE
processome containing the
PATTERN
U3 snoRNA that WD40
1.E-10
of pre-18S-1
rRNA processing of 20S pre-rRNA (1e-07)
0.005
hydrolase activity
D.L[EVF]
48 DLL
Binding motif for clathrin heavy chain earHelicase_C
1.E-05
-0.9
Y
0.010
QQ..[LSP]
48
Zn_clus
1.E-03
-0.9
0.010
[KNG]K[SEG]K
48 of 66S pre-ribosomal particles; plays an essential role in processingMMR_HSR1
of precursors to the large
1.E-02
ribosomal subunit
-0.9 RNAs
0.009
[DRA]ISN[STA]
48 of nuclear organization, RNA processing and transport; regulated
Y by Prp20p,
IBN_N
1.E-02
Yrp4p, Yrb30p,
-0.4 Cse1p
nucleocytoplasmic
and Kap95p; yeast Gsp2p
transport
homolog
(0.001)
0.005
LSP1: Primary component of eisosomes, which are large
L[VKM]RA
immobile patch structures
48at the[KR]R
cell cortex associated
CLV_PCSK_KEX2_1
with endocytosis, along with Pil1p and Sur7p;
Cpn60_TCP1
null mutants show activation
1.E-02 of Pkc1p/Ypk1p
-0.1
stress resistance pathways
0.006
Q[PVY][QNW]E
48
in the degradation of ubiquitinated substrates; bound by ubiquitin-proteinPCI
ligases Ubr1p and
1.E-03
Ufd4p; localized
0.4mainlyproteasome
to the nucleus throughout
complex the
(sensu
cell cycle
Eukaryota) (1e-08)
0.007
SKP1: Evolutionarily conserved kinetochore protein that
[VI]K.LT[GNI]
is part of multiple protein complexes,
48
including the SCF ubiquitin ligase complex, the CBF3Ycomplex that
ubiquitin
binds centromeric1.E-04
DNA, and the RAVE
1.4 complex
protein
that regulates
tag (0.001)
assembly of the V-ATPase
0.005
transport
L..[GIM]L
48
Y
Mito_carr
1.E-13
1.5
Y
0.010
L.[WFV]A
48 PLARTLSVAGLP
Calmodulin-dependent protein kinase
Y
IV substrate
MFS_1motif
1.E-13
1.6
Y
0.010
HTB1: One of two nearly identical (see HTB2) histoneLE..[GV][NI]A
48
1.E-04
transcriptional
1.6 activation, meiotic DSB formation and H3 methylation
Y
0.006
ARP4: Nuclear actin-related protein involved in chromatin
[RQV]L.[RIY]RG
remodeling, component 48
of chromatin-remodeling
[KR]R
enzyme
CLV_PCSK_KEX2_1
complexes
Histone
1.E-07
1.7
HR..[KRC][PTL]
including
R..K
SH3 binding
subunits;
motifconstituent
for GADSofSH3
66S pre-ribosomal
recognizing
Pkinase
slp-76
particlesmotif (nonconventional)
1.E-14
2.8
0.008
R[DLI].K
including
L..RR..KK
ERK docking
subunits;
motif
constituent
in RSK stringent
of 66SYpre-ribosomal
Pkinase
particles
1.E-12
2.9
0.009
matsuyama_Cytosol
I..[RNE]D
48
Pkinase
1.E-02
3.4
Y
0.012
W..G[CVI]
48 bodies at late anaphase; promotes mitotic exit by directly switching
Y
on thePkinase
1.E-26
4.5
Y
0.008
KR[KRE]
48 KR
CLV_PCSK_PC1ET2_1
Zn_clus
1.E-07
4.9
0.010
HRT1: RING finger containing subunit of Skp1-Cullin-F-box
LP.[EAT][IYA]
ubiquitin protein ligases
48(SCF);
P.LP.K
required for Gic2p,SH3
Far1p,
binding
Sic1p motif,
and Cln2p
stringent
degradation;
Crk SH3
maybinding
tether Cdc34p
F-box
site (Class
(a ubiquitin
2) 1.E-06
conjugating enzyme
7.8 or E2)
cellular
and Cdc53p
protein
(a cullin)
catabolism
subunits of
(1e-07)
SCF
0.009
nucleoplasm
[QIM]Q..Q
48
nucleoplasm (1e-11)
0.010
Q[QNI].Q[QNH]
48
0.010
oxidoreductase activity
SS.[SNQ][SNT]
48 S[ST]
0.010
morphogenesis
[STY]ST[LNV]H
48 S[ST]
0.008
cellular morphogenesis
[STY]ST[LNV]H
48 S[ST]
0.008
[NQG][SDG]NKI
and nuclear
NK.D
Motif for subunits
specificity of guanine in purine binding proteins
Y
0.005
KSK[RQY][SNM]
48the transition
KR
from G2 to M
CLV_PCSK_PC1ET2_1
phase; accumulates during G2 andYM, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
0.006
RAD53: Protein kinase, required for cell-cycle arrest LD.[IET]S[TPI]
activated
WLDLE
14-3-3 binding
whenmotif
interacting
from with
peptide
hyperphosphorylated
screen
DNA
a role
integrity
in initiation
checkpoint
of DNA replication
(0.01)
Y
0.005
SSN3: Cyclin-dependent protein kinase, component[QLR]Q[QST]QL
of RNA polymerase II holoenzyme;
48 involved
[ST]Q in phosphorylation
ATM kinase
of the RNA
phosphorylation
polymerase II C-terminal
site
domain; involved in glucose repression
transcription regulator activity (0.001)
0.006
[STV]LA[PVH]E
branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
Y
0.005
HRD1: Ubiquitin-protein ligase required for endoplasmic
[AYE]LAK[LGM]
reticulum-associated degradation
48
(ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger
0.005
PHO80: Cyclin, negatively regulates phosphate metabolism;
K[AVY]..I[DTM]L
Pho80p-Pho85p (cyclin-CDK
48 YIDL
complex) phosphorylates
SH2 ligand
Pho4pfor
andSyp
Swi5p;
(also
deletion
tyr is of
phosphorylated
PHO80 leads to by
aminoglycoside
the insulin receptor)
supersensitivity; truncated form of PHO80 affects vacuole inheritance
0.007
SSB2: Cytoplasmic ATPase that is a ribosome-associated
K[EPR].[LEV]YQ
molecular chaperone, functions
48 [EDY]Y
with J-protein partner
TC-PTP
Zuo1p;phosphatase
may be involved
substrate
in the folding
Y
motif
of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1
0.006
NOP15: Constituent of 66S pre-ribosomal particles,[KVG]K..[KRE]K
48 biogenesis;
K[KR].[KR]
localizes toNuclear
both nucleolus
localization
and cytoplasm
motif
0.009
K..[AKR]A
to Rpl20Bp
K[KR].[KR]
and has similarity
Nuclear
to rat L18a
localization
ribosomalmotif
protein
Y
0.009
CDC5: Polo-like kinase with similarity to Xenopus Plx1
L[DCF].N[GQA]N
and S. pombe Plo1p; found48
at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate
0.006
RPS1B: Ribosomal protein 10 (rp10) of the small (40S)
IA.[SQ][RKM]R
Rps1Ap
[KR]R
and has similarity CLV_PCSK_KEX2_1
to rat S3a ribosomal protein
Y
translation (1e-04)
0.005
LSM8: Lsm (Like Sm) protein; forms heteroheptameric
A[KCP]..KV[LMT]
complex (with Lsm2p, Lsm3p,
50 Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA,
U4/U6
pre-snoRNA,
x U5 tri-snRNP
and pre-rRNA
complex
TPK1: cAMP-dependent protein kinase catalytic subunit;
EK..[KSQ]
50 in response
K..[ST]to nutrients PKA
via the
kinase
Ras-cAMP
substrate
signaling
motif
pathway;Yinhibited by regulatory subunit Bcy1p in the absence of cAMP;
RNApartially
binding
redundant
(0.01) with Tpk2p and Tpk3p
HCA4: Putative nucleolar DEAD box RNA helicase;
KK..[KSM]S[KDP]
high-copy number suppression50
of a U14
RKK.[ST]
snoRNA processing
ZIPmutant
kinasesuggests
phosphorylation
an involvement
motifin 18S rRNA synthesis
10
9
10
9
10
10
10
9
10
10
9
8
9
8
10
9
10
10
10
10
10
10
8
10
10
10
10
7
10
10
10
10
9
10
9
10
9
10
10
10
10
10
10
10
10
8
9
10
10
7
9
9
8
10
9
7
7
10
9
9
10
8
9
9
9
7
8
9
10
10
10
8
10
9
9
10
9
9
10
9
10
9
10
10
10
10
10
10
10
10
9
10
10
10
10
8
8
7
9
10
10
10
10
9
9
10
8
10
10
10
8
10
10
10
10
10
10
10
10
10
10
10
9
8
10
10
8
9
10
8
10
10
10
9
protein_40_YLR180W
protein_40_YLR009W
protein_40_YLL045C
protein_40_YKL014C
protein_40_YJR066W
protein_40_YIL019W
protein_40_YGL200C
protein_40_YFR052W
protein_40_YFR028C
protein_40_YFL037W
protein_40_YDR427W
protein_40_YDR324C
protein_40_YDR225W
protein_40_YDR174W
protein_40_YDR172W
protein_40_YDR145W
protein_40_YCR031C
protein_40_YCL059C
matsuyama_Cytosol
genetic_YNL153C
genetic_YER083C
protein_40_YBR160W
protein_40_YGR252W
matsuyama_nucleolus
yeast-324_GO-0030528
yeast-504_GO-0006350
protein_40_YPL093W
yeast-261_GO-0016491
oshea_cytoplasm
matsuyama_Golgi
yeast-413_GO-0005215
protein_40_YOL133W
protein_40_YAR019C
protein_40_YNL031C
yeast-222_GO-0009308
protein_40_YJR002W
yeast-261_GO-0016491
protein_40_YPR103W
protein_40_YPR103W
protein_40_YML010W
protein_40_YAR019C
protein_40_YDR496C
yeast-685_GO-0016740
protein_40_YJR066W
yeast-706_GO-0043412
yeast-238_GO-0017111
yeast-648_GO-0050791
yeast-388_GO-0007275
yeast-240_GO-0006807
yeast-223_GO-0003735
protein_40_YPR110C
protein_40_YPL204W
protein_40_YPL076W
protein_40_YOR326W
protein_40_YOR326W
protein_40_YMR242C
protein_40_YLR372W
protein_40_YLR186W
protein_40_YLR180W
protein_40_YKL021C
protein_40_YJR145C
protein_40_YJL138C
protein_40_YJL081C
protein_40_YIL094C
protein_40_YHR079C
protein_40_YGR218W
protein_40_YGR086C
protein_40_YDR510W
protein_40_YDR510W
protein_40_YDR496C
protein_40_YDR388W
protein_40_YDR356W
protein_40_YBR009C
protein_40_YBL026W
protein_40_YAR007C
protein_40_YPR103W
protein_40_YDL188C
protein_40_YDR087C
yeast-410_GO-0007049
protein_40_YBR031W
yeast-238_GO-0017111
yeast-248_GO-0016072
protein_40_YCL059C
yeast-410_GO-0007049
protein_40_YNL061W
protein_40_YLL008W
yeast-437_GO-0044429
yeast-294_GO-0006366
protein_40_YPL240C
protein_40_YBR159W
protein_40_YPR119W
protein_40_YBR106W
protein_40_YDR324C
yeast-238_GO-0017111
protein_40_YNL186W
protein_40_YDR224C
yeast-216_GO-0006325
yeast-216_GO-0006323
yeast-207_GO-0003677
yeast-980_GO-0051179
yeast-601_GO-0005829
protein_40_YLR197W
oshea_microtubule
oshea_microtubule
yeast-261_GO-0016491
protein_40_YPL203W
protein_40_YKR048C
protein_40_YDL013W
yeast-256_GO-0016462
protein_40_YNL175C
yeast-335_GO-0016772
yeast-335_GO-0016772
yeast-335_GO-0016772
yeast-661_GO-0050789
yeast-942_GO-0043232
yeast-942_GO-0043228
yeast-596_GO-0044425
yeast-301_GO-0044451
yeast-233_GO-0006629
yeast-223_GO-0003735
yeast-220_GO-0044255
yeast-205_GO-0005856
protein_40_YPL211W
protein_40_YPL076W
protein_40_YOR133W
protein_40_YOL139C
protein_40_YOL077C
protein_40_YNL118C
protein_40_YMR290C
protein_40_YMR128W
protein_40_YMR049C
protein_40_YLL039C
protein_40_YLL008W
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
SAM1: S-adenosylmethionine synthetase, catalyzesEV..[AEF][TGN]
of ATP to the sulfur atom of methionine; one of two differentiallyYregulated isozymes (Sam1p and Sam2p)
0.009
10
0.009
10
0.009
10
0.005
10
[LFM]L..N[LRV]G
48 that controls growth in response to nutrients by regulating translation,
Y
transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis
0.005
9
FAF1: Protein required for pre-rRNA processing and[LNF]S.I[KFW]L
40S ribosomal subunit assembly
48
0.005
9
EMP24: Integral membrane component of endoplasmic
[AQ][AIL]..YG
reticulum-derived COPII-coated
48 vesicles, which function in ER to Golgi transport
secretory pathway (0.01)
0.007
9
RPN12: Subunit of the 19S regulatory particle of the[LPN]DIL[EFD]
26S proteasome lid; synthetically
48 lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
0.005
10
CDC14: Protein phosphatase required for mitotic exit;
RK.S[LKI][EPR]
located in the nucleolus until48
liberated
RRK.[ST]
by the FEAR andZIP
Mitotic
kinase
Exit Network
phosphorylation
in anaphase,
motif
enabling it to act on key substrates to effect a decrease in CDK/B-cyclin
regulationactivity
of exitand
from
mitotic
mitosis
exit (1e-04)
0.005
9
E[TNR]K[EGL]K
Y
Y
0.005
8
RPN9: Non-ATPase regulatory subunit of the 26S proteasome,
LA.[GLR][GDR]E
has similarity to putative
48 proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly
proteasome
defectscomplex (sensu Eukaryota) (0.001)
Y
0.005
9
S[GWH]E[GVK]V
48 the
[ED]GSG[DE]
U3 snoRNA that isGlycosaminoglycan
involved in processingattachment
of pre-18S rRNA
site
0.005
8
HTA1: One of two nearly identical (see also HTA2) DE.[EYT][ERG]E
histone H2A subtypes; core histone
48 required
E[ST][EA]REA[RK].[LI]
for chromatinRIBOSOMAL_S28E
PATTERN
function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.007
10
K[SNG]..N[DVY]S
48genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
0.005
8
SUP35: Translation termination factor eRF3; alteredV[LHK].[GE]GS
protein conformation creates 48
the [PSI(+)]
R.GSF
prion, a dominant
PKCdelta
cytoplasmically
kinaseinherited
phosphorylation
protein aggregate
Y site (peptide
that alters
screen)
translational fidelity and creates a nonsense suppressor phenotype
0.006
10
E[ALP]K[EHA]L
48
0.005
10
RPS14A: Ribosomal protein 59 of the small subunit,
S[KGF].[LKV]RA
48and [KR]R
CLV_PCSK_KEX2_1
mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E.cytosolic
rat S14 ribosomal
(sensuproteins
Eukaryota) (1e-06)
0.005
7
[SQT]L[DPT]AT
48 assembly
LP.TG
of 40S ribosomal
C-terminal
subunit sorting signal which targets surface proteins of Staphylococcus aureus to
ribonucleoprotein
the cell wall peptidoglycan;
complex Sortase
(1e-05)cleaves between Thr and Gly and C-termini
0.005
is used for 10
crosslinking in cell wall
matsuyama_Cytosol
[SVH]L.D[LSP]
48 LFDLM
Binding motif in Clint for clathrin TD domain
regulation of cell cycle (0.01)
0.011
10
N..[DMT]K
cytoskeletal part (1e-07)
Y
0.009
10
GET2: Subunit of the GET complex; required for meioticL...[ILMV]E
nuclear division and for the
48retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function chromosome organization and biogenesis (sensu Eukaryota) (1e-23) 0.009
10
[QDY]Y..[ETP]LP
48 [EDY]Y
associates with G1TC-PTP
cyclins (CLNs)
phosphatase
and G2/Msubstrate
cyclins (CLBs)
motifwhich direct the CDK to specific substrates
0.006
10
GK.[GRP][ARS]K
47 H3; KTPAKEE
GSK-3,
ADA and
ERK1,
SAGA
ERK2,
histoneCDK5
acetyltransferase
substrate
Y
motif
complexes;
Histone
founding member
1.E-13
-3
nuclear
N-acetyltransferase
nucleosome
superfamily
(1e-08)
0.005
9
matsuyama_nucleolus
[HM]R.[GKP]R
47 R.[RK]R
CLV_PCSK_FUR_1
DEAD
1.E-10
-1.8
nucleolus (1e-24)
0.013
10
HT.[EQS]K[PNY]
47
zf-C2H2
1.E-18
-1.4
0.009
10
transcription
T..N[DSR]
47
Zn_clus
1.E-11
-1.3
0.010
10
T[DR].A[ASL]R
47 [AG]R
60S ribosomal
matriptase
subunit biogenesis;
protease site
constituent
Y
of 66S
DEAD
1.E-07 member
-1.3
of the ODN
ribosomal
family of nucleolar
large subunit
G-proteins
assembly and maintenance (1e-08)
0.006
9
G[PLY].[GV]L
47 GP
Protease TTP cleavage site
Ferric_reduct
1.E-05
-0.9
oxidoreductase activity (1e-52)
0.010
10
oshea_cytoplasm
PQ[QEH]
47 HPQ
zf-C2H2
1.E-02
-0.9
Y
0.009
10
matsuyama_Golgi
Y.L[GFY]
47
MFS_1
1.E-03
-0.9
Y
0.011
10
AV[VMG][TIA]
47
MFS_1
1.E-02
-0.5
0.010
10
E[LIF]..A[IAC]
47(SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p
F-box (a ubiquitin1.E-02
conjugating enzyme
-0.4 or E2)
cullin-RING
and Cdc53p ubiquitin
(a cullin) subunits
ligaseofcomplex
SCF
(1e-04)
Y
0.009
10
I[SPK][SRT]KS
1.E-02
-0.2
protein amino acid phosphorylation (0.01)
0.005
10
HHT2: One of two identical histone H3 proteins (see
L[AEF]..A[ACS]R
47 for[AG]R
chromatin assembly,
Protease
involved matriptase
protease site telomericHistone
0.4
methylation,
nuclear chromatin
(0.001)
Y
0.005
8
amine metabolism
GA.[IKV][VIA]
47
PALP
1.E-03
0.5
amine metabolism (1e-61)
0.010
10
MPP10: Component of the SSU processome, which [LQR]LA[VI]G
47
interacts with and controls the stability of Imp3p and Imp4p, essential
WD40
1.E-06
to human Mpp10p
0.7
Y
0.005
10
VV.[GLV][AGP]
47
ADH_N
1.E-03
0.9
0.010
10
P[FPY]G[VAW]
47 of the
LVPRG
proteasome
Protease Thrombin
Y
Proteasome
1.E-12
1.5
Y
0.006
9
[ASG]G..[APG]D
47 of the proteasome
Y
Proteasome
1.E-20
1.8
proteasome core complex (sensu Eukaryota) (1e-19)
0.008
10
[KEG]K.[IAL]A
47
pre-mRNA processing
1.E-05
1.8
Y
0.009
10
A[GRS]GS[VLF]
47 bodies
G[SA]LNK
at late anaphase;GDP-mannose
promotes mitoticbinding
exit by directly
motif in
switching
transporter
on thePkinase
1.E-05
2.6
0.005
9
PUF6: Pumilio-homology domain protein that binds P[TGL]R[EFQ]L
47sequences
[AG]Rin the 3' UTR Protease
and represses
matriptase
its translation,
protease
resulting
site in proper asymmetric
DEAD localization
1.E-07
of ASH1 mRNA
3.6
ribosome assembly (1e-09)
0.005
10
[ILV]G.G[STA]F
47 G[GA]G[ASC][FY]S.K[DE]
ADOMET_SYNTHETASE_2 PATTERN
Pkinase
1.E-28
4.8
0.011
10
[TYN]P..R[RVF]
47 thatP..R..KP
controls growth in SH3
response
binding
to nutrients
motif for
by regulating
GRB2 C-term
translation, transcription,
GATA ribosome1.E-02
5.3 transport
regulation
and autophagy;
of nitrogen
involved
utilization
in meiosis (1e-05)
0.008
10
KP.N[ILF][LMG]
47
Pkinase
1.E-39
5.5
0.011
10
[HGL]R.G[RYQ]
47 RGG
Alternative integrin binding site in
Y FMDV virus
Helicase_C
1.E-25
11.6
Y
0.011
10
[AVY]C..C[RDE]
47 C..C
Zn_clus
1.E-19
17.4
0.010
10
development
A[PH].[PSE]P
47 [ST]P
LIG_WW_4LIG_WW_4
0.010
10
A.[IEV]L
47 [FHYM].A[AV].[VAC]L[MV].[MI]
LIG_Sin3_2LIG_Sin3_2
Y
0.010
10
structural constituent of ribosome
P..P[SIQ]
47 [RKY]..P..P
LIG_SH3_1LIG_SH3_1
0.010
10
RPC40: RNA polymerase subunit, common to RNAT[LFA].IN[GKC]
polymerase I and III
47
0.005
9
S[VQG]..[PLA]QN
47 SQ
ATM kinase
segregation;
substratebinds
motifthe CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
0.005
9
GPI2: Protein involved in the synthesis of N-acetylglucosaminyl
[VIA]G.LI[IYT]
phosphatidylinositol
47(GlcNAc-PI),
IY
the first intermediate
cFGR and
in the
Csk
synthesis
kinase of
phosphorylation
glycosylphosphatidylinositol
site (peptide
(GPI)
screen)
anchors; homologous to the human PIG-C protein
0.005
8
MYO2: One of two type V myosin motors (along with[RIE]I[RWF]NL
47transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle
0.005
8
MYO2: One of two type V myosin motors (along with MYO4)
E[LS].GI[DL]
involved in actin-based
0.006
10
N[KNI].[KQ]KV
to Rpl20Bp and has similarity to rat L18a ribosomal protein
0.005
8
SUR4: Elongase, involved in fatty acid and sphingolipid
V[SLK].LV[LIV]
biosynthesis; synthesizes 47
very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
0.005
9
EMG1: Protein required for the maturation of the 18SD[TAK]LL[TAI]
rRNA and for 40S ribosome 47
production;
LLTP
associated withWD40
spindle/microtubules;
domain of Cdc4
nuclear
binding
localization
motif,depends
Thr must
onbe
physical
phosphorylated,
interaction with
CPD
Nop14p;
motifmay bind
small
snoRNAs
nucleolar ribonucleoprotein complex (1e-09)
Y
0.005
8
SAM1: S-adenosylmethionine synthetase, catalyzesG[IKY].[DRI]EL
Y
0.005
10
MAK11: Protein involved in an early, nucleolar step of
[KNR]K[SDE]K
47 essential
for cell growth
DEHYDRIN_2
and replication
PATTERN
of killer M1 dsRNA virus; contains four beta-transducin repeats
nucleolus (1e-28)
Y
0.009
10
KA..[AEV]E[IVQ]
20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
ribonucleoprotein complex (0.01)
0.006
9
TIF2: Translation initiation factor eIF4A, identical to Tif1p;
[SCT][NTE]IDE
DEA(D/H)-box RNA helicase
47 that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
0.006
10
[NPL]EN[DES]E
[ST]E
enzyme
G protein-coupled
complexes
nucleoplasm part (0.01)
0.005
9
[KYV][SIQ]KNK
Y
0.005
7
IRE1: Serine-threonine kinase and endoribonuclease;
[IRD][PRQ].ATT
transmembrane protein that47
mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.005
9
SN.T[NQK][SGP]
47 from
N.[TS]
the nucleus
Y
Y
0.005
7
PIL1: Primary component of eisosomes, which are large
[VIA]D[SMN]DD
immobile cell cortex structures
47 associated
D.D
with endocytosis;
Ribosenull
moiety
mutants
of UDP
show and
activation
manganese
of Pkc1p/Ypk1p
bindingstress
site in
resistance
glucuronyl
pathways;
transferase
detected in phosphorylated state in mitochondria
0.005
9
SMT3: Ubiquitin-like protein of the SUMO family, conjugated
DP[AKR]V[TAE]
47 proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
0.005
9
V.[DKG]A
47 proteins; regulates chromatid cohesion, chromosome segregation,
Y
carboxylic
ring dynamics
acid metabolism (1e-04)
0.008
10
PUF6: Pumilio-homology domain protein that binds [DKE]D.[EKD]E
47sequences
D.D in the 3' UTR Ribose
and represses
moietyitsoftranslation,
UDP andresulting
manganese
in proper
binding
asymmetric
site inlocalization
glucuronyl
of transferase
ASH1 mRNA
0.009
10
RVS167: Actin-associated protein, subunit of a complex
P[PLR].[PAV]P
(Rvs161p-Rvs167p) involved
47 in regulation
[RK]SP[RP][RKH]
of actin cytoskeleton,
Cdc2 kinase
endocytosis,
substrateand
motif
viability following starvation or osmotic stress; homolog of mammalian
cellamphiphysin
cortex (1e-06)
Y
0.009
10
L[KLE].N[IQT]S
47 involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated bymicrotubule
Mps1p in cell cycle-dependent
nucleation (1e-06)
manner
0.005
9
HHF1: One of two identical histone H4 proteins (see also
E..[DVP]E
HHF2); core histone required
47 for chromatin assembly and chromosome function; contributes
Y to telomeric silencing; N-terminal domain involved in maintaining
chromatin
genomic
modification
integrity (1e-11)
0.009
10
LSM2: Lsm (Like Sm) protein; part of heteroheptameric
A[KCH]..[KGM]VL
complexes (Lsm2p-7p and47
either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP andU4/U6
possiblyxinvolved
U5 tri-snRNP
in processing
complex
tRNA, snoRNA,
(0.01) and rRNA
0.006
9
RFA1: Subunit of heterotrimeric Replication Protein A (RPA),
[VRQ]LRG
which is a highly conserved
47 single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.005
8
IS[VRG]S[TIG]
47 S[ST]
vacuole (1e-07)
Y
0.006
10
PRE2: Beta 5 subunit of the 20S proteasome, responsible VEYA
46 of the
VIYAAPF
proteasome
Abl kinase substrate motif
Y
Proteasome
1.E-09
-3.8
proteasome core complex, alpha-subunit complex (sensu Eukaryota) (1e-11)
0.005
9
PPH22: Catalytic subunit of protein phosphatase 2A, functionally
VE[YCR]A
redundant with Pph21p;
46
methylated at C terminus; forms alternate complexes with
Yseveral Proteasome
1.E-08
-3.1
proteasome
and regulationcore
of mitosis
complex, alpha-subunit complex (sensu Eukaryota) (1e-10)
0.005
10
RRP1: Essential evolutionarily conserved nucleolar protein
K..K[KYG]
necessary for biogenesis
46of 60S
P.[ST]PKK.KK
ribosomal subunits
Cdc2
and like
processing
proteinofkinase
pre-rRNAs
substrate
to mature
motif
rRNAs, associated
Brix
with several
1.E-04
distinct 66S-2.7
pre-ribosomal
cytoplasm
particlesorganization and biogenesis (1e-24)
0.008
10
cell cycle
L..N[SKN]
46
Y
Pkinase
1.E-04
-1.8
cell cycle (1e-26)
Y
0.010
10
RPL4A: N-terminally acetylated protein component
GR..[RGA][AYG]G
46 nearly
[AG]R
identical to Rpl4Bp
Protease
and has
matriptase
similarity to
protease
E. coli L4site
DEADproteins 1.E-07
-1.8
0.005
10
L[AYM]K
46 LLKIL
AP-2 binding motif in CXCR2 receptor Helicase_C
1.E-11
-1.6
Y
0.010
10
rRNA metabolism
T[GCS].GK[TVN]
46 [SAG]GGTG[SA]G
TUBULIN PATTERN
Helicase_C
1.E-17
-1.2
Y
0.009
10
KRR1: Essential nucleolar protein required for the TD..A[RSV][GEY]
synthesis of 18S rRNA and for the
46 assembly of 40S ribosomal subunit
DEAD
1.E-03
-1.2
0.005
9
cell cycle
KR...[SKM]
46 KR
CLV_PCSK_PC1ET2_1
Pkinase
1.E-05
-1.1
cell cycle (1e-19)
Y
0.009
10
K..[EVK]E
46 of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to theBrix
1.E-03
-1
cytoplasm
particles
Y
0.008
10
[DTE]V[AF]AR
including
[AG]R
Proteasesubunits;
matriptase
constituent
protease
of 66S
sitepre-ribosomal
DEAD
particles
1.E-03
-1
0.005
10
mitochondrial part
K[RNH]K
46 KRKQISVR
Phosphorylase kinase substrate motif Helicase_C
1.E-03
-0.8
0.010
10
[QN]Q.[LSN]L
46
Zn_clus
1.E-03
-0.6
0.010
10
HSP82: Hsp90 chaperone required for pheromone signaling
V[DVA]L
46of Hsf1p;
DLLdocks with Tom70p
Binding
for mitochondrial
motif for clathrin
preprotein
heavy
delivery;
chainpromotes
ear
AA_permease
telomerase DNA binding
1.E-02and nucleotide
-0.2 addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
Y
0.008
10
L[GLI]..[LIA]F
46
in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate
MFS_1 high levels
1.E-04
of dihydrosphingosine,
0
transporter
phytosphingosine
activity
and medium-chain
(1e-07)
ceramides
Y
0.009
10
[LQI]L[ESG]K
Pkinase
via a destruction
1.E-03
0.1
cell cycle
degradation
Y
0.008
10
[AYI]F.G
46double
FIGQY
null mutant exhibits
Ankryn
enhanced
G binding
synthesis
motif
of repressible
in neurofascin
Yacid phosphatase
MFS_1
at high inorganic
1.E-06
0.1
Y
0.009
10
K..[KTD]L
46 the
K..[ST]
U3 snoRNA that isPKA
involved
kinase
in processing
substrateofmotif
pre-18S rRNA
WD40
1.E-06
0.2
0.008
10
E.[YDG]R
46 [AG]R
Helicase_C
1.E-11
0.5
Y
0.010
10
NT..[AT][ERM]
may regulate
T..[SA]
silencing by acting
FHA of
on KAPP
Sir4p; involved
bindinginmotif,
Thr must be phosphorylated
regulating
Pkinase
Gap1p and 1.E-07
0.8
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-06)
Y
0.006
10
L[ARE].[NQK]AA
46
1.E-06
transcriptional
0.8 activation,
nuclear
meiotic
chromatin
DSB formation
(1e-06)
and H3 methylation
Y
0.005
7
[ENK]EE
46 EED
Ankyrin B C-terminal motif that binds Myb_DNA-binding
internal Ankyrin repeats1.E-05
1
Y (1e-19) 0.010
10
DNA packaging
[ENK]EE
46 EED
Ankyrin B C-terminal motif that binds Myb_DNA-binding
internal Ankyrin repeats1.E-05
1
Y (1e-19) 0.010
10
DNA binding
T[GHT][EKA]K
46 GAKRH
HISTONE_H4 PATTERN
zf-C2H2
1.E-07
1.1
DNA binding (1e-59)
0.010
10
localization
LS.[IAL][FGI]
46
Adaptin_N
1.E-02
1.4
0.009
10
cytosol
[EL][EQV]..DDM
46
Ribosomal_60s
1.E-11
1.6
0.006
8
[LYM]LSA[SRD]
Y
its maturation;
WD40overexpression
1.E-04
causes spindle
1.7 orientation
cytoplasm
defects organization and biogenesis (1e-06)
0.005
8
oshea_microtubule
SK.[TY][RY]L
46
Kinesin
1.E-09
2.1
microtubule (1e-07)
0.006
10
oshea_microtubule
KL[TND][RYI]L
46
Kinesin
1.E-08
2.1
microtubule motor activity (1e-10)
0.006
8
[LGF]G.[KMI]G
46
2-Hacid_dh_C
1.E-05
2.2
0.010
10
GG[ED]LF
46 in response to nutrients via the Ras-cAMP signaling pathway; inhibited byPkinase
regulatory subunit Bcy1p
1.E-06
in the absence
2.3 of cAMP;
protein
partially
amino
redundant
acid phosphorylation
with Tpk1p and Tpk3p
(1e-06)
0.005
8
KP.[NEV][LID]L
microtubule dynamics during mitosis; controls bud morphogenesis; involvedPkinase
in the transport of H2A
1.E-12
and H2B histones
2.4 to the
protein
nucleus;
kinase
phosphorylated
activity by
(1e-10)
CK2
0.006
10
SLX5: Subunit of the Slx5-Slx8 substrate-specific ubiquitin
H[RSW]..K[PKW]
ligase complex; stimulated
46 by prior
R..Kattachment of SUMO
SH3 binding
to the substrate
motif for GADS SH3 recognizing
Pkinase
1.E-05
2.8
Y
0.006
10
[VIH]LD[ETG]
46
ABC_tran
1.E-09
2.9
Y
0.010
10
[LNK]FSA[TFD]
contains an RNA recognition motif (RRM) and has similarity to Nop12p, which DEAD
1.E-05of pre-18S4rRNA RNA helicase activity (1e-04)
0.005
8
[LCD]G..[LHR]Y
groups
46
Pkinase
1.E-19
4.8
10
transferase activity, transferring phosphorus-containingT...[MRC]AP
groups
46
Pkinase
1.E-28
5.1
Y
0.010
10
E[YFV]..G[GV]
groups
46
Pkinase
1.E-28
5.5
10
[AVY]C..C[RDE]
46 C..C
Zn_clus
1.E-19
17.2
0.010
10
R[LRS]K[VET]
46
0.010
10
R[LRS]K[VET]
46
0.010
10
membrane part
[IFE]L.L[IGW]
46
0.010
10
nucleoplasm part
[QIM]Q..Q[QHD]
46
0.010
10
lipid metabolism
[KQ]K.L[NP]P
46 DLPPP
EVH1 binding motif
cellular lipid metabolism (1e-08)
0.006
9
P...T
46
0.010
10
cellular lipid metabolism
F.F[GLM]
46 F.F
WASP Homology 1 binding motifY
0.010
10
cytoskeleton
SP[TSR][KEP]
46 SP
ERK1, ERK2 Kinase substrate motif
0.010
10
[DKG]D.[EKC]E
of 66S D.E
Sec24pSec24pSec24p
physically interacts with Nop8p and the exosome subunit Rrp43p
0.009
10
S[LRF][LKF]VL
46(GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human
nuclear
PIG-C envelope-endoplasmic
protein
reticulum network (0.001)
0.005
8
EFT1: Elongation factor 2 (EF-2), also encoded by F[DQI]..[ATV]KE
EFT2; catalyzes ribosomal translocation
46 KTKEGC
during protein synthesis;
Repeating
contains
motif
diphthamide,
in alpha-synuclein
the uniquethat
posttranslationally
binds apolipoproteins
modified histidine residue specifically ADP-ribosylated by diphtheria toxin
0.005
8
CDC33: Cytoplasmic mRNA cap binding protein; the[GVN]G.[RF]GR
46 for[AG]R
mediating cap-dependent
Protease
mRNA
matriptase
translation
protease
via interactions
site with the translation initiation factor eIF4G (Tif4631p or Tif4632p)
0.005
10
E[ETI][ERH]E
46to defects
EEEEYFELV
in rRNA processing
EGFR
and
kinase
a blocksubstrate
in the assembly
motif of large ribosomal subunits; possesses a sigma(70)-like RNA-binding
cytoplasm
Y
0.009
10
LK[KT][AGH]I
46
the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family
Y
0.005
9
EE..[EKG][EKN]
46 EED
highly enriched inAnkyrin
nuclear pore
B C-terminal
complex fractions;
motif that
constituent
binds
Y internal
Ankyrin repeats
particles
Y
0.008
10
ECM16: Essential DEAH-box ATP-dependent RNAE[DLK].[SHM]AL
helicase specific to the U3 snoRNP,
46 predominantly nucleolar in distribution, required for 18S rRNA
Y synthesis
Y
0.005
8
[ATD]V..ET[LHV]
46 of 66S pre-ribosomal particles; homologous to mammalian Bop1
0.005
9
UBI4: Ubiquitin, becomes conjugated to proteins, marking
S[ILA]DK[LQT]
them for selective degradation
46 via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
Y
0.005
10
EE..[DGK][GEK]
including
EED
Ankyrin Bsubunits;
C-terminal
constituent
motif that
of 66S
binds
pre-ribosomal
internal Ankyrin
particlesrepeats
0.009
10
RLP24: Essential protein with similarity to Rpl24Ap EE..[EDK][EKM]
and Rpl24Bp, associated with 48
pre-60SEED
ribosomal subunitsAnkyrin
and required
B C-terminal
for ribosomal
motif
large
that
subunit
bindsbiogenesis
internal Ankyrin repeats
[ATG]R..A
to Rpl8Ap
[AG]R
and has similarity
Protease
to rat L7amatriptase
ribosomal protein;
protease
mutation
site results in decreased amounts of free 60S subunits
[AFV]K[SWR]DE
48 associated
KR
with the 27SA2
CLV_PCSK_PC1ET2_1
pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
Y
Y
protein_40_YLL008W
protein_40_YKL014C
protein_40_YJR066W
protein_40_YJL109C
protein_40_YIL144W
protein_40_YIL061C
protein_40_YIL018W
protein_40_YGR274C
protein_40_YGR086C
protein_40_YGR085C
protein_40_YGL147C
protein_40_YGL106W
protein_40_YGL105W
protein_40_YGL030W
protein_40_YFL037W
protein_40_YFL002C
protein_40_YER148W
protein_40_YER112W
protein_40_YER018C
protein_40_YER006W
protein_40_YER006W
protein_40_YDR356W
protein_40_YDR303C
protein_40_YDL147W
protein_40_YDL055C
protein_40_YDL055C
protein_40_YCL059C
protein_40_YBR159W
protein_40_YBL027W
oshea_ER
oshea_bud
genetic_YPL055C
genetic_YNL153C
oshea_nucleolus
protein_40_YMR242C
protein_40_YNL061W
protein_40_YLR222C
protein_40_YPL153C
protein_40_YPL131W
yeast-1433_GO-0006139
protein_40_YGR090W
oshea_nucleus
yeast-470_GO-0006259
oshea_bud_neck
protein_40_YMR047C
protein_40_YLR276C
matsuyama_Golgi
protein_40_YOL069W
protein_40_YKR081C
yeast-251_GO-0005886
yeast-240_GO-0006807
protein_40_YNL186W
protein_40_YBR245C
protein_40_YNL030W
yeast-312_GO-0006414
protein_40_YOL012C
yeast-980_GO-0051179
yeast-256_GO-0016462
protein_40_YDL153C
protein_40_YNL272C
protein_40_YLR002C
protein_40_YLL034C
protein_40_YDL153C
yeast-661_GO-0050789
yeast-436_GO-0031323
protein_40_YHR052W
protein_40_YMR229C
yeast-1939_GO-0003824
yeast-1340_GO-0044267
protein_40_YHR052W
yeast-1036_GO-0005739
protein_40_YPR119W
protein_40_YPL153C
protein_40_YPL153C
protein_40_YPL012W
protein_40_YOR326W
protein_40_YOR181W
protein_40_YOR096W
protein_40_YOL135C
protein_40_YNL308C
protein_40_YNL308C
protein_40_YNL189W
protein_40_YNL118C
protein_40_YNL118C
protein_40_YMR128W
protein_40_YMR047C
protein_40_YMR047C
protein_40_YML063W
protein_40_YML063W
protein_40_YLR197W
protein_40_YLR075W
protein_40_YKL203C
protein_40_YKL009W
protein_40_YJL164C
protein_40_YJL092W
protein_40_YJL081C
protein_40_YJL074C
protein_40_YIL144W
protein_40_YIL094C
protein_40_YGR090W
protein_40_YGL207W
protein_40_YGL106W
protein_40_YGL076C
protein_40_YER133W
protein_40_YER110C
protein_40_YER110C
protein_40_YER018C
protein_40_YDR496C
protein_40_YDR225W
protein_40_YDR167W
protein_40_YDL055C
protein_40_YDL031W
protein_40_YDL031W
protein_40_YDL029W
protein_40_YBR010W
protein_40_YBL003C
oshea_vacuole
oshea_bud
oshea_bud
matsuyama_ER
genetic_YPL055C
genetic_YER083C
ucsf_loc_k_means_G6
protein_40_YNL061W
protein_40_YHR052W
yeast-410_GO-0007049
protein_40_YBR031W
yeast-544_GO-0016070
yeast-207_GO-0003677
yeast-256_GO-0016462
protein_40_YPL211W
yeast-320_GO-0006355
protein_40_YKL172W
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
6
2
2
2
2
2
2
2
2
2
2
K[RKP][SRA]K
including
KRsynthesis of 60S ribosomal
CLV_PCSK_PC1ET2_1
subunits; constituent of 66S pre-ribosomal particles
(1e-32)
E[ESD].[KIE]E
46 associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
nucleolus
T[LHA]..AN[SDK]
46 that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis
Y
E[LKI]..L[EAF]T Ndc80 complex
46
(Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint
microtubule
nucleation
assembly
(0.01)and clustering
SNP1: Component of U1 snRNP required for mRNA[TFN]S[YLQ]KK
splicing via spliceosome; may46
interact
SQ
with poly(A) polymerase
ATM kinase
to regulate
substrate
polyadenylation;
motif homolog of human U1 70K protein
nuclear mRNA splicing, via spliceosome (0.001)
NK.[KQR][KF]V
subunit, identical to Rpl2Ap
46and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression
Y
is upregulated at low temperatures
TAF1: TFIID subunit (145 kDa), involved in RNA polymerase
P[LDE]LT[SEI]
II transcription initiation,
46 has P.L
histone acetyltransferase
Motif activity,
in C-Fos
involved
for protein
in promoter
instability
binding
Y and G1/S progression
PIL1: Primary component of eisosomes, which areR[STR]..R[STK]S
46 associated
R.S
with endocytosis;
PKA kinase
null mutants
substrate
showmotif
activation of
Y Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
K..[ARK]A
to Rpl11Ap;
K[KR].[KR]
involved in ribosomal
Nuclear
assembly;
localization
depletion
motif
causes degradation of proteins and RNA of the 60S subunit; has similarity
cytosolic
to E. coli
ribosome
L5 and rat
(sensu
L11
Eukaryota) (1e-47)
RPL9A: Protein component of the large (60S) ribosomalS.[LSG]S
Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
MLC1: Essential light chain for Myo1p, light chain for
LS..S[AKT][IQR]
Myo2p; stabilizes Myo2p by binding
46 S..S
to the neck region; interacts
Casien kinase
with Myo1p,
I phosphorylation
Iqg1p, and Myo2p
site,
to coordinate
1st Ser must
formation
be phosphorylated
and contraction of the actomyosin ring with targeted membrane deposition
Y
ARC1: Protein that binds tRNA and methionyl- andFL..[KRD][NQP]L
46 and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
Y
[SVK][KHM]KA
46L30 ribosomal
RRRK[GK]SF[RK][RK]KA
protein; involved
PKC gamma
in pre-rRNA
kinase
processing
substrate
in the
motif
nucleolus; autoregulates splicing of its transcript
[LDT]ALI[IGQ]
Y
SPB4: Putative ATP-dependent RNA helicase, nucleolar
EE.E[EAG][EKW]
protein required for synthesis
46 of 60S
RE..E
ribosomal subunits
Ironatbinding
a late step
motif
in the
in ferritin
pathway;
L-chain
sediments
andwith
yeast
66SIron
pre-ribosomes
transport in
protein
sucrose gradients
Y
SPT15: TATA-binding protein, general transcription ET.L[KTQ][IGQ]
46 to form the preinitiation complex at promoters, essential for viability
[RHY]E..RL[RED]
either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
SPC25: Component of the evolutionarily conserved [QEI][QMA].LQ
microtubule
clustering cytoskeleton (0.001)
E[ENI]E[EMG]
required for export
46of 60S
S[DE][DE]E
ribosomal subunits
BARD1
from theBRCT
nucleus
KQ.[LWK][DEF]A
required for export
nucleolus (1e-06)
KI.[KG][LMY]N
nucleation (1e-07)
manner
RSC3: Component of the RSC chromatin remodelingH[LPQ]Q[LGY]
46 forHPQ
maintenance of proper
Biotin
ploidy
binding
and regulation
motif in streptavidin
of ribosomal protein genes and the cell wall/stress response; highly similar
RSCtocomplex
Rsc30p (0.01)
RPN5: Essential, non-ATPase regulatory subunit of[ILD]A.[LNV]DE
46
to mammalian
AEVD p55 subunitProtease
and to another
Caspase
S. cerevisiae
10
regulatory subunit, Rpn7p
D[FAG].SE[LVI]
guanyltransferase),
46 synthesizes
[ST]E GDP-mannose
G protein-coupled
from GTP and mannose-1-phosphate
receptor kinase 1 substrate
in cell wallmotif
biosynthesis; required for normal cell wall structure
V[LRD]..L[SPA]E
guanyltransferase),
46 synthesizes
[ST]E GDP-mannose
G protein-coupled
receptor kinase 1 substrate
in cell wallmotif
biosynthesis; required for normal cell wall structure
E[ETF].DQ
[IVA]G.[ALC]I
46
in the promoter region; mutants exhibit reduced VLCFAYsynthesis, accumulate high levels of dihydrosphingosine,transporter
phytosphingosine
activity
and medium-chain
(1e-07)
ceramides
[VYN]A[KNA]KR
to Rpl19Ap
KR and has similarity
CLV_PCSK_PC1ET2_1
to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while
cytosolic
the double
ribosome
null mutation
(sensu
is lethal
Eukaryota) (1e-07)
oshea_ER
L[VIY]F
46 ENLYFQ[GS] Protease TEV - stringent
Y
Y
oshea_bud
N[KSN].L[KTD]T
46
bipolar bud site selection (0.001)
Y
LGE1: Protein of unknown function; null mutant forms
[QID]IQQ[QAN]
abnormally large cells, and homozygous
46
[NER]D..E
cell cycle (1e-10)
oshea_nucleolus
K[LEN]D
45 [NT]K.D
Y
WD40
1.E-02
-1.9
nucleolus (1e-09)
[GQ][LI]DIP
DEAD
1.E-07
-1.5
[DNR]VA[AS]R
45 of[AG]R
27S pre-rRNA andProtease
large ribosomal
matriptase
subunitprotease
biogenesis;
site
localized to the
DEAD
1.E-05
-1.1
ATP-dependent
particles
[ARM]GG[DH]
45 GGRGG
the U3 snoRNA thatArginine
is involvedmethyl
in processing
transferease
of pre-18S
substrate
rRNA motifWD40
(PRMT1)
1.E-04
-1.1
snoRNA binding (0.001)
Y
[SPA]S.E
to DNA damage; 45
PHRad9p; also interacts
1.E-02with ARS1
-1and plays
DNA
a role
damage
in initiation
response,
of DNA replication
signal transduction (1e-05)
Y
DVA[ACQ][RTP]
coli L18DVAD
Protease
proteins;Caspase
binds 5S rRNA
2 -stringent
and is required
Y
for 60SDEAD
subunit assembly 1.E-03
-1
S.N
45 [LF][HQ]SENG[LIVF][LIVF][GA]
COA_TRANSF_2 PATTERN
Helicase_C
1.E-04
-0.9
UTP22: Possible U3 snoRNP protein involved in maturation
E..[EDW]D
of pre-18S rRNA, based
45on computational
P.E..[FYWHDE]
analysis
LIG_TRAF6LIG_TRAF6
of large-scale protein-protein interaction data WD40
1.E-02
-0.8
Y
oshea_nucleus
LF[LFY]
45 PL[YF][FY]..N Trafficks functional nicotinic acetylcholine
PI3_PI4_kinase
receptors from ER 1.E-02
to cell surface-0.7
DNA metabolism
QQ..[GLS][QKL]
45
Myb_DNA-binding 1.E-02
-0.6
oshea_bud_neck
EA.[KF][LMG]E
45
PH
1.E-03
-0.5
establishment of cell polarity (sensu Fungi) (1e-06)
LE.[DAR][EPD]
of the LEHD
Protease
GLFG
Caspase
motif that9interacts with mRNA exportIBN_N
factor Mex67p and1.E-02
with karyopherin
-0.4
Kap95p;nucleocytoplasmic
homologous to Nup100p
transport (1e-07)
DBP9: ATP-dependent RNA helicase of the DEAD-box
K[KLI]..[KRV]K
family involved in biogenesis
45of the 60S ribosomal subunit
Brix
1.E-02
-0.3
matsuyama_Golgi
I[LFV]..V[AIY]
45
Y
MFS_1
1.E-02
0
NUF2: Component of the evolutionarily conserved kinetochore-associated
E[ESY][LN]K Ndc80 complex
45
SMC_N
spindle checkpoint
1.E-03
0.1
condensed
clustering nuclear chromosome (1e-07)
Y
RPF2: Essential protein involved in the processing of pre-rRNA
RK[RHT]
and the assembly 45
of the 60S
KAPRK[QH][LI]
ribosomal subunit;
HISTONE_H3_1
interacts with ribosomal
PATTERN
protein L11; localizesHelicase_C
0.1 of 66S
cytoplasm
pre-ribosomal
organization
plasma membrane
VL[GTI]
45 LTP
RAF1 kinase substrate motif
MFS_1
1.E-05
0.5
L..[ILMV]G
45
tRNA-synt_2b
1.E-05
0.5
VLG[TG][PHK]
may regulate
LGG[HD]S[LI]
silencing by acting
Thioester
on Sir4p;
binding
involved
motif
for non-ribosomal regulating
peptide
Pkinase
synthesis
Gap1p andof
1.E-06
possibly
gramicidin
other transporters;
0.8
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-04)
ISW1: Member of the imitation-switch (ISWI) class R[LNV].RR[GHL]
of ATP-dependent chromatin remodeling
45 [KR]R
complexes; ATPase
CLV_PCSK_KEX2_1
that forms a complex with Ioc2p and Ioc4p to regulate
Histone
transcription1.E-04
elongation, and1.3
a complex
chromatin
with Ioc3p to
assembly
repress transcription
or disassembly
initiation (0.001)
HHF2: One of two identical histone H4 proteins (seeL[EQ]LA[GER]
45 forDALDL
chromatin assembly
14-3-3
and chromosome
binding motif
function;
in ExoS
contributes
Y to telomeric
Histone
silencing; N-terminal
1.E-04
domain involved
1.5 in maintaining
nuclear chromatin
genomic integrity
(0.001)
G[LM]FD
45 LFDLM
Binding motif in Clint for clathrin Y
TD domain
Ribosomal_60s
1.E-12
1.6
Y
HTZ1: Histone variant H2AZ, exchanged for histone H2A
RL.[RI][RA]G
in nucleosomes by the SWR1
45 complex; involved in transcriptional regulation through prevention of theHistone
spread of silent heterochromatin
1.E-07
1.6
nuclear nucleosome (1e-06)
localization
L..[GYM]L
45
Y
Mito_carr
1.E-11
1.8
L..A[KRM]
45 L.YA.L
SHP1 N-terminal SH2 domain binding
Y
motif
ABC_tran
1.E-10
1.8
Y
SAS10: Component of the small (ribosomal) subunit[KQC]P.N[ILMV]
45for pre-18S
CP[ST]N[ILV]GT
rRNa processing;
GUANIDO_KINASE
essential nucleolar PATTERN
protein that, when
Y overproduced,
Pkinase
disrupts silencing
1.E-20
2.7
Y
[KA]P.N[ILV]
Pkinase
1.E-22
2.9
[GRE]K.AA[FKS]
45precursors to mediate their intranuclear transport; also binds to chromatin toDEAD
3.2
cytoplasm
organization
initiationand biogenesis (1e-06)
Y
RIX7: Putative ATPase of the AAA family, required for
G[KHL][TGI]AA
export of pre-ribosomal large45
subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and
DEAD
nuclear periphery
1.E-03
depending on3.2
growth conditions
ATP-dependent RNA helicase activity (0.01)
SAS10: Component of the small (ribosomal) subunit
K[PHS][DNEQ]N
Pkinase
disrupts silencing
1.E-24
3.4
Y
E..[LSH]L
45
Pkinase
1.E-04
3.5
Y
K..R
45 R...K..R
Motif in Ebola virus that eliminates
Y IFN-betazf-C2H2
production
1.E-07
3.6
LFS[AEM][TPF]
3.6
[DK]V..R[GAM]L
45 isR.L
Cyclin
of 18S
A motif
rRNA
that
andbinds
N-terminal
cdk2region
complexes
is required
Helicase_C
component of small
4 ribosomal
rRNAsubunit
processing
(SSU) processosome
(1e-05)
catalytic activity
Y[RML].P[EQV]
45 [VIL].Y[MLF].P SHP1, SHP2 SH2 domain binding motif Pkinase
1.E-30
5.1
cellular protein metabolism
HRD[ILMV][KLS]
MGMT PATTERN
Pkinase
1.E-55
6.7
[HLG]R.G[RTK]
45 role
RGG
Alternative
specificity;
integrin
alsobinding
copurifies
site
with
in66S
FMDV
pre-ribosomal
virus
Helicase_C
particles
1.E-08
6.9
Y
mitochondrion
ML[RAS]
45 LRT
LKB1 Kinase substrate motif
Y
QY..[ETV][LA]P
45the transition
Y..[LIV]from G2 to M
JAK2
phase;
autophosphorylation
accumulates during G2
signal
and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
RAD53: Protein kinase, required for cell-cycle arrestS[ESN]..[DEL]N
activated
S[ST]
MDC1 BRCT
when
domain
interacting
binding
motif
Y
Y
SP..[NST]
to DNA damage; 45
activated
SPby trans autophosphorylation
ERK1, ERK2
when
Kinase
interacting
substrate
motif
cellacortex
role in initiation
part (0.01)
of DNA replication
Y
RRP12: Protein required for export of the ribosomal[RWG]H..F[LCH]
subunits; associates with the RNA
45 components of the pre-ribosomes; contains HEAT-repeats
nucleolus (1e-08)
MYO2: One of two type V myosin motors (along with
[DPV]A.[KFG]KL
45transport of cargos; required for the polarized delivery of secretory
Y vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle
LAS17: Actin assembly factor, activates the Arp2/3[SAK][SMN]..QLQ
branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome
actin
protein
cytoskeleton
(WASP)
(0.01)
Y
RA.[RKG]
subunit, nearly identical to
45Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal
ribonucleoprotein
proteins
complex (1e-30)
Y
MED7: Subunit of the RNA polymerase II mediator complex;
V[APF]..[IY]Q
45 VP subunits to formInterleukin
the RNA polymerase
converting
II holoenzyme;
enzyme protease
essential for transcriptional regulation
[GKL]L[RAT]IG
and functionally
FIGQY interacts with
Ankryn
Krr1pG binding motif in neurofascin
nucleolus (0.01)
K[DIN].[KNY]EK
and functionally
YE
interacts with
TPK-IIB/P38Syk
Krr1p
kinase phosphorylation site (peptide screen)
SRP1: Karyopherin alpha homolog, forms a dimer with
[LVS]DN[LSA]E
karyopherin beta Kap95p to
45mediate
[ST]E
import of nuclear G
proteins,
protein-coupled
binds the nuclear
receptor
localization
kinase signal
1 substrate
of the substrate
motif during import; may also play a role in regulation of protein degradation
[LNV]K..E[LER]D
45 EED
the 5' cap structureAnkyrin
from mRNAs
B C-terminal
prior to their
motif
degradation;
that binds
member
internal
of the
Ankyrin
Nudix repeats
hydrolase family
Y
GF.[ACP][GYQ]
45
Y
ECM16: Essential DEAH-box ATP-dependent RNAK[KRA]..SK[DPH]
45 predominantly
KKR..S nucleolar
Phosphorylation
in distribution, required
site forfor
MLCK
18S rRNA synthesis
S[KW].A[FGP]S
of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p;protein
homologous
import
to Nup100p
NUP116: Subunit of the nuclear pore complex (NPC)T[TQ]..[GP]LF
of the F..LF
Androgen
GLFGreceptor
motif thatmotif
interacts
thatwith
interacts
mRNA export
with AF2
factor Mex67p and with karyopherin Kap95p;nuclear
homologous
pore
to (1e-08)
Nup100p
[KGL]G.KV[TKV]
Rps1Ap and has similarity to rat S3a ribosomal protein
KK.[APE]F[TIR]
translation (1e-05)
DE..[PDS][KEQ]
Y
its maturation; overexpression causes spindle orientation
nucleolus
defects(1e-21)
[AKL]A[REG]KA
subunit, responsible for joining
45 the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of
cytosolic
the QM gene
ribosome
family (sensu Eukaryota) (1e-07)
L[IYV]F[KDG]K
45 that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis
Y
N[KNF].K[KF]V
nucleolus
nucleolus (0.01)
TPK1: cAMP-dependent protein kinase catalytic subunit;T.T[TNK]
45 in response
[KR].TQT
to nutrients LIG_Dynein_DLC8_1
via the Ras-cAMP signaling pathway;Yinhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p
KP[EVS]
for proper
KP..[QK]
LIG_SH3_4LIG_SH3_4
to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
A[AQI]EI[LKA]
of chromatin-remodeling enzyme complexes
SMC3: Subunit of the multiprotein cohesin complex required
[VDM]T.[IDC]P
for sister chromatid cohesion
45
in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
L[QKD].[EQM]N Ndc80 complex
45
(Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein
Y
involved in chromosome segregation, spindle checkpoint
microtubule
cytoskeleton
assembly
(1e-06)
and clustering
[VLQ]LAA[RVF]
45 for the fourth step in the biosynthesis of lysine, in which homo-isocitrate
Y
is oxidatively decarboxylated to alpha-ketoadipate
Y
K..[KRT]R
45on computational
[KR]R
analysis
CLV_PCSK_KEX2_1
of large-scale protein-protein interaction data
SPT16: Subunit of the heterodimeric FACT complex[KNA]L.Q[SQR]I
45Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure
MLC1: Essential light chain for Myo1p, light chain forN[EN]..PL[LFA]
45 RPL
VEGFRwith
andMyo1p,
neuropilin
Iqg1p,binding
and Myo2p
peptide
Y to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
EK..[AC]S[LSR]
Rpl7Bp
S[ST]
and has similarity MDC1
to E. coliBRCT
L30 and
domain
rat L7 ribosomal
binding motif
proteins;
Y
contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
V[VKG]V[VSD]G
cytosol (1e-04)
GLC7: Catalytic subunit of type 1 serine/threonine [EQM]P..[KPR]EE
protein phosphatase, involved in
45manyP..P
processes includingSH3
glycogen
general
metabolism,
ligand, sporulation, and
Y mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
KAP123: Karyopherin beta, mediates nuclear import[GTN]L.GN[KY]
assembly
LFG
into ribosomes and
Protease
import ofPapain
histonessubstrate,
H3 and H4;alocalizes
prototype
to the
cysteine
nuclearproteinase
pore, nucleus, and cytoplasm; exhibitssnRNP
genetic interactions
protein import
with RAI1
KAP123: Karyopherin beta, mediates nuclear importGK.[TS]F[VGC]
assembly
[RK].[ST]
into ribosomes and
PKA
import
kinase
of histones
substrate
H3 and
motif
H4; localizes
Y to the nuclear pore, nucleus, and cytoplasm; exhibitsnuclear
organization
with RAI1
and biogenesis (0.001)
Y
SPC25: Component of the evolutionarily conservedTL.[PNG]N[DGM]
complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome
Y segregation, spindle checkpoint activity and kinetochore clustering
PUF6: Pumilio-homology domain protein that binds ASH1
SE.D[KL][KF]
mRNA at PUF consensus
45sequences
E[ST]D
in the 3' UTR Ankyrin
and represses
G binding
its translation,
motif in resulting
KNCQ2inand
proper
KNCQ3
asymmetric
potaqssium
localization
channels
of ASH1 mRNA
nucleolus (1e-06)
HTA1: One of two nearly identical (see also HTA2) histone
KRI[SIK][GNE]
H2A subtypes; core histone
45 required
KR for chromatinCLV_PCSK_PC1ET2_1
assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
[SQE]LI[EAG]D
Y
V[VFE]..V[SLT]L
guanyltransferase),
45 synthesizes
P.V.L GDP-mannose
Shadow-Chromo
domain binding motifin cell wall biosynthesis; required for normal cell wall structure
Y
[SKQ]K..K[RKS]
45 KR
CLV_PCSK_PC1ET2_1
particles; essential protein involved
Y in ribosome biogenesis
EE..[DKG][GEK]
45 EED
Ankyrin
particles;
B C-terminal
essential protein
motif involved
that binds
in ribosome
internal biogenesis
Ankyrin repeats
ARP2: Essential component of the Arp2/3 complex,E[AD].[KRM]KG
HHT1: One of two identical histone H3 proteins (see
[EVD]S..S[EQG]D
45 forS..S
chromatin assembly,
Casien
involved
kinase
I phosphorylation site,
telomeric
1st Serand
must
HMbe
silencing;
phosphorylated
regulated by acetylation, methylation, and mitotic phosphorylation
HTA2: One of two nearly identical (see also HTA1)EN..[TKV]N[DPV]
45 required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
Y
oshea_vacuole
S[TFM]..[SLQ]TL
45 PLTLP
RAF1 kinase substrate motif
storage vacuole (1e-04)
oshea_bud
[DIK]L..[EVF]ID
45 VEID
Protease Caspase 6 -stringent
bud (1e-08)
oshea_bud
I[ECP].[LQY]LV
45
exocyst (1e-06)
Y
matsuyama_ER
G..F[YFL]
45
Y
Y
E..[DIG]E
45
chromosome organization and biogenesis (sensu Eukaryota) (1e-17)
GET2: Subunit of the GET complex; required for meiotic SK[RLP]
45retrieval
SKRKYRK
of HDEL proteinsTP1
fromPATTERN
the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function chromosome organization and biogenesis (sensu Eukaryota)
Y
(1e-13)
LF[LTW]
45
MFS_1
1.E-05
1.1
EE..[EKG][EKV]
44 ofEED
27S pre-rRNA andAnkyrin
large ribosomal
B C-terminal
subunit motif
biogenesis;
that binds
localized
internal
to the
DEAD
Ankyrin
nucleolus;
repeats
constituent
1.E-02
-1.8
cytoplasm
particles
CIC1: Essential protein that interacts with proteasome components
AR..[ARD]and has a potential
44 role
[AG]R
Protease
specificity;
matriptase
also copurifies
proteasewith
site
Y66S pre-ribosomal
-1.7
Y
cell cycle
T...N[SEG]
44
Pkinase
1.E-03
-1.6
cell cycle (1e-20)
Y
RPL4A: N-terminally acetylated protein component of the
AR..[ARD]
large (60S) ribosomal subunit,
44 nearly
[AG]R
identical to Rpl4Bp
Protease
and has
matriptase
similarity to
protease
E. coli L4site
and
Y rat L4 ribosomal
DEADproteins 1.E-02
-1.6
Y
RNA metabolism
DE[EAD][EDH]
44 YDE[PDV]
SH2 ligand for Nck1 and Nck2 (Tyr must Helicase_C
-1.5
Y
DNA binding
P.S[SLA]
44 YMPMS
PI3 Kinase p85 SH2 domain binding motif zf-C2H2
1.E-09
-1.5
DNA binding (1e-17)
[LIP]T[GKR]E
44 CP[LP]T.E[ST].CGM_CSF PATTERN
Y
Helicase_C
1.E-12
-1.3
Y
H[RTF]..R[TKF]
DEAD
-1.3
Y
LP[SKH]
44 [KR].LP..P
SH3 ligand motif for Sho1p
Y
Zn_clus
1.E-09
-1.2
Y
EBP2: Essential protein required for the maturation of 25S
K..[KIM]K
rRNA and 60S ribosomal
44subunit
P.[ST]PKK.KK
assembly, localizes
Cdc2
to the
like
nucleolus;
protein constituent
kinase substrate
motif
Brix
particles
1.E-04
-1.2
Y
D[TKF][LHK]LT
46 LLTP
the U3 snoRNA thatWD40
is involved
domain
in processing
of Cdc4ofbinding
pre-18Smotif,
Y
rRNA Thr must be phosphorylated, CPD motif
0.009
0.008
0.005
0.005
0.005
0.005
0.005
0.005
0.005
0.009
0.008
0.005
0.005
0.009
0.005
0.007
0.005
0.005
0.009
0.009
0.005
0.005
0.005
0.005
0.005
0.005
0.006
0.009
0.005
0.009
0.005
0.005
0.008
0.009
0.005
0.005
0.005
0.008
0.005
0.009
0.008
0.009
0.010
0.006
0.008
0.009
0.011
0.009
0.008
0.009
0.009
0.005
0.005
0.005
0.006
0.006
0.009
0.010
0.007
0.008
0.005
0.005
0.009
0.009
0.010
0.005
0.005
0.009
0.009
0.009
0.009
0.005
0.008
0.008
0.005
0.005
0.005
0.008
0.005
0.005
0.005
0.005
0.005
0.005
0.005
0.006
0.005
0.005
0.005
0.008
0.006
0.005
0.005
0.008
0.008
0.005
0.005
0.009
0.005
0.008
0.005
0.005
0.005
0.005
0.005
0.005
0.005
0.005
0.005
0.005
0.005
0.005
0.009
0.009
0.005
0.005
0.005
0.007
0.005
0.005
0.011
0.008
0.008
0.027
0.008
0.008
0.009
0.008
0.009
0.009
0.009
0.005
0.009
0.008
10
10
9
10
9
9
8
9
10
10
10
10
9
10
9
10
9
7
10
10
9
9
10
10
7
9
9
10
9
10
9
10
10
10
9
8
9
10
10
10
10
10
10
8
10
10
10
10
10
10
10
9
10
9
10
8
10
10
10
10
7
10
10
10
10
8
9
10
10
10
10
9
10
10
10
9
9
10
9
7
9
10
7
9
10
10
10
9
8
10
8
10
8
10
10
9
9
10
8
10
9
7
7
10
10
9
9
10
9
7
7
7
10
10
9
10
9
9
10
9
10
10
10
10
10
10
10
10
10
10
10
8
10
10
protein_40_YOR206W
protein_40_YGL111W
protein_40_YDL153C
protein_40_YAR019C
protein_40_YPL153C
protein_40_YNL186W
protein_40_YKR081C
yeast-251_GO-0005886
yeast-244_GO-0000279
yeast-1433_GO-0006139
protein_40_YPR144C
protein_40_YLR129W
yeast-255_GO-0042254
yeast-255_GO-0007028
yeast-244_GO-0000279
half_life_belle_q3
protein_40_YPR119W
yeast-251_GO-0005886
yeast-1115_GO-0006996
protein_40_YBL002W
yeast-256_GO-0016462
protein_40_YGL105W
protein_40_YLL034C
yeast-299_GO-0005730
yeast-238_GO-0017111
protein_40_YLR002C
protein_40_YLL045C
yeast-942_GO-0043232
yeast-942_GO-0043228
yeast-217_GO-0007046
protein_40_YGL111W
yeast-335_GO-0016772
yeast-335_GO-0016772
yeast-685_GO-0016740
yeast-460_GO-0006351
yeast-341_GO-0045449
yeast-792_GO-0006412
yeast-457_GO-0007001
yeast-284_GO-0005740
yeast-267_GO-0000003
yeast-238_GO-0017111
yeast-235_GO-0000278
yeast-233_GO-0006629
yeast-233_GO-0006629
yeast-1062_GO-0016020
protein_40_YPR144C
protein_40_YPL203W
protein_40_YPL153C
protein_40_YOR061W
protein_40_YOL069W
protein_40_YOL001W
protein_40_YNL307C
protein_40_YNL124W
protein_40_YNL110C
protein_40_YMR240C
protein_40_YMR117C
protein_40_YLR432W
protein_40_YLR423C
protein_40_YLR423C
protein_40_YLR423C
protein_40_YLR340W
protein_40_YLR180W
protein_40_YLR180W
protein_40_YLL011W
protein_40_YKL203C
protein_40_YKL104C
protein_40_YJR022W
protein_40_YJL081C
protein_40_YIL095W
protein_40_YHR196W
protein_40_YHR196W
protein_40_YHR135C
protein_40_YHR041C
protein_40_YHR041C
protein_40_YGR128C
protein_40_YGR086C
protein_40_YGL106W
protein_40_YGL076C
protein_40_YGL048C
protein_40_YGL019W
protein_40_YER177W
protein_40_YER133W
protein_40_YER110C
protein_40_YER110C
protein_40_YER036C
protein_40_YDR447C
protein_40_YDR145W
protein_40_YDL213C
protein_40_YDL147W
protein_40_YDL055C
protein_40_YDL055C
protein_40_YCR086W
protein_40_YCL059C
protein_40_YAR007C
oshea_cytoplasm
matsuyama_Spindle_or_SPB
matsuyama_Cytosol
matsuyama_Cytosol
genetic_YLR262C
yeast-299_GO-0005730
matsuyama_Cytosol
protein_40_YHR066W
yeast-235_GO-0000278
protein_40_YPL126W
protein_40_YGL111W
protein_40_YNL272C
yeast-217_GO-0007046
protein_40_YDR356W
yeast-200_GO-0006519
protein_40_YHR066W
protein_40_YDR388W
yeast-631_GO-0050794
yeast-630_GO-0051244
yeast-235_GO-0009653
yeast-235_GO-0000902
protein_40_YCL059C
yeast-244_GO-0000279
yeast-752_GO-0016787
protein_40_YDL014W
protein_40_YER082C
protein_40_YOL069W
protein_40_YDL013W
oshea_bud_neck
protein_40_YPL153C
yeast-1721_GO-0016043
protein_40_YBR159W
yeast-980_GO-0051179
protein_40_YPR137W
protein_40_YBR106W
protein_40_YNL031C
protein_40_YBR106W
protein_40_YHR030C
yeast-685_GO-0016740
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
NOC2: Protein that forms a nucleolar complex with Mak21p
E[EKD].E.E
that binds to 90S and 44
66S pre-ribosomes,
SEDEE as wellCKII
as a nuclear
kinase complex
phosphorylation
with Noc3psite
that(peptide
binds to 66S
screen)
Brix
pre-ribosomes; both
1.E-02
complexes mediate
-1.1 intranuclear
nucleolus
transport
(1e-26)
of ribosomal precursors
Y
0.009
-1.1
Y
0.005
-1.1
protein serine/threonine kinase activity (0.001)
Y
0.005
-1
0.007
N.K[ARY]
to DNA damage; 44
activated
KRby trans autophosphorylation
CLV_PCSK_PC1ET2_1
AnkRad9p; also interacts
1.E-02with ARS1
-0.8and plays a role in initiation of DNA replication
Y
0.008
QA..[QWR][SYF]
Pkinase
Gap1p and 1.E-02
-0.7
primarily located in the nucleus
Y
0.005
RPF2: Essential protein involved in the processing[TRM]G.[GMS]KT
of pre-rRNA and the assembly 44
of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizesHelicase_C
-0.7 of 66S
ribosome
pre-ribosomal
biogenesis
particles (1e-07)
0.005
plasma membrane
S..[SHF]T
44 S..[ST]
Y
MFS_1
must first be -0.6
phosphorylated)
0.009
M phase
N..I[NLP]
44
Y
MutS_III
1.E-03
-0.6
M phase (1e-16)
0.009
I..[EKA]R
44 [KR]R
CLV_PCSK_KEX2_1
Helicase_C
1.E-04
-0.3
0.009
LL[ACF][VIA]G
and nuclear
FIGQY
Ankryn Gsubunits
binding motif in neurofascin
WD40
1.E-02
-0.2
Y
0.005
DIP2: Nucleolar protein, specifically associated with A[QM]..K[EIN]
the U3 snoRNA, part of the large
44 ribonucleoprotein complex known as the small subunit (SSU) processome,WD40
required for 18S rRNA
1.E-03
biogenesis,-0.2
part of the
snoRNA
active pre-rRNA
binding
processing
(1e-15)complex
Y
0.006
KR..[KVG]
44 KR
CLV_PCSK_PC1ET2_1
DEAD
1.E-02
0.2
0.009
KR..[KVG]
44 KR
CLV_PCSK_PC1ET2_1
DEAD
1.E-02
0.2
0.009
M phase
[SQN]L..[KER]K
44
MutS_III
1.E-02
0.2
M phase (1e-90)
0.009
half_life_belle quantized 3
S..D[GNT]
44 S..D
Pyruvate dehydrogenase kinaseYsubstrate zf-C2H2
motif
1.E-02
0.4
regulation of biological process (1e-04)
0.018
I.D Cdc28p to promote
44the transition
[IV].DS[GAS][GASC][GAST][GA]T
from G2 to M
ALKALINE_PHOSPHATASE
phase; accumulates during G2 and
PATTERN
M, then targeted
Pkinase
via a destruction
1.E-06
0.5
cell cycle
degradation
Y
0.008
plasma membrane
F..[AVW]Y
44
MFS_1
1.E-02
0.6
0.010
G..[GNL]K
44 G.G..G
Phosphate, FAD, NADH, binding motif
WD40
1.E-05
1
chromosome organization and biogenesis (sensu Eukaryota) (1e-57) 0.009
V[LQW]E[YRQ]L
44
1.E-03
transcriptional
1.5 activation,
chromatin
meiotic DSB
assembly
formation
orand
disassembly
H3 methylation
(0.001)
0.005
T[AGC]..[ETL]R
44
Y
Ras
1.E-12
2
Y
0.010
ARC1: Protein that binds tRNA and methionyl- and E[YQF]..G[GQD]
44 and
[FYW]..G.GY[KR]F
Gus1p), deliveringENT_VIR_OMP_2
tRNA to them, stimulating
PATTERN
catalysis, and ensuring
Pkinase
the cytoplasm; 2.7
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-11)
Y
0.007
D[EIN]AD[RPL]
subunits
from the nucleus;DEAD_ATP_HELICASE
distributed between the nucleolus,
PATTERN
nucleoplasm, and
DEAD
nuclear periphery
1.E-03
depending on 3
growth conditions
rRNA processing (0.001)
0.005
nucleolus
[GEI]K[TWK]LA
44
DEAD
1.E-08
3.1
nucleolus (1e-17)
0.009
[VIF]LD[EAG]
44
ABC_tran
1.E-13
3.4
Y
0.010
[SK]GKT[AGN]
3.5
RNA
factorshelicase
and replication
activity
initiation
(1e-04)
0.005
[RTE]A[ADG]R
to Rpl8Ap
[AG]R
and has similarity
Protease
to rat L7amatriptase
ribosomal protein;
protease
mutation
site results in decreased
DEAD amounts1.E-04
3.6
0.009
[DAR]EA[DNR]
44 E[ST][EA]REA[RK].[LI]
RIBOSOMAL_S28E PATTERN
DEAD
1.E-08
3.8
nucleolus (1e-20)
0.009
[DAR]EA[DNR]
44 E[ST][EA]REA[RK].[LI]
RIBOSOMAL_S28E PATTERN
DEAD
1.E-08
3.8
nucleolus (1e-20)
0.009
ribosome biogenesis
[PTF]TRE[LKY]
44 RE..E
Iron binding motif in ferritin L-chain and yeast
DEAD
Iron transport protein
1.E-10
3.8
Y
0.008
[TR]G.[GM]KT
44biogenesis
DEAD
1.E-08
3.9
0.005
Y[LMC]H
44 Y[VLTFIC]
LIG_SH2_STAT5
Pkinase
1.E-47
4.7
Y
(1e-58)0.009
G[YKH].P[FWY]
groups
44 [WFY][KR]P[WFY]
LIG_WRPW_2
Pkinase
1.E-24
5.5
Y
(1e-32)0.010
[YVW]A[ILMV]K
44
Y
Pkinase
1.E-52
5.8
Y
0.009
RK[RPD]
44 VRKRTLRRL PAK1 kinase substrate motif
Zn_clus
1.E-05
7.7
0.009
CR.[RKS][KCH]
44 R.[ST]
PKA consensus phosphorylationYsite
Zn_clus
1.E-24
17.9
0.010
protein biosynthesis
[KW]MS[KA]S
44 WM
Substrate binding motif of barley alpha-amylase 1 (AMY1) enzyme
ligase activity, forming aminoacyl-tRNA and related compounds (1e-16)
0.007
EE[DNS][EKQ]
44 EED
S..[DNEQ]E
44 S..[ED]
Casein kinase II substrate motif
0.009
reproduction
[SPT]S[SFG]S
44 S[ST]
reproduction (1e-12)
0.009
KT..A[KIY][AGS]
44 T..[SA]
0.006
mitotic cell cycle
[NEV]D.D[EDV]
44 D.D
Ribose moiety of UDP and manganese binding site in glucuronyl transferase
mitotic cell cycle (1e-96)
0.009
lipid metabolism
F.F[LGV]
44 F.F
WASP Homology 1 binding motifY
lipid metabolism (1e-09)
0.010
lipid metabolism
P[LPR].L[LFH]I
44 P.L
Motif in C-Fos for protein instability
0.006
membrane
[SLA]Y[ILMV]V
44 Y[VLTFIC]
LIG_SH2_STAT5
Y
0.009
AK..[KHM][KSI]V
and nuclear export of 40S ribosomal subunits
0.005
[RHG]R.S[VFS]
44 in response
R.S to nutrients PKA
via the
kinase
Ras-cAMP
substrate
signaling
motif
pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk3p
0.009
RAD53: Protein kinase, required for cell-cycle arrestSI[LEP]P[VRA]
activated
PPR
LIG_WW_3LIG_WW_3
Y
Y
0.004
CKA2: Alpha' catalytic subunit of casein kinase 2, aK[LHY]..K[STM]K
44in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
0.005
EI..[LMI][KEC] Ndc80 complex
44
(Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore
microtubule
clustering
0.009
[DWP]G..[LNS]VN
44 HLVNK
Motif for
Pho4p
targeting
and Swi5p;
CD44
deletion
to basolateral
of PHO80 membranes
leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance
0.005
MCK1: Protein serine/threonine/tyrosine (dual-specificity)
R..S[VIN]
kinase involved in control
44of chromosome
KKR..S segregation
Phosphorylation
and in regulatingsite
entry
forinto
MLCK
meiosis;
Y related to mammalian glycogen synthase kinases of the GSK-3 family
0.008
[RKA]A..[VKG]A
processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity cytosolic
to Gar1p and
ribosome
other RNA-binding
(sensu proteins
Eukaryota) (1e-19)
0.009
NOP15: Constituent of 66S pre-ribosomal particles, [LA][EHW].INN
44 biogenesis; localizes to both nucleolus and cytoplasm
0.005
CUS1: Protein required for assembly of U2 snRNP T[VEG]FS[EKT]
into the spliceosome, forms a complex
44 S[ST]
with Hsh49p and Hsh155p
RNA splicing factor activity, transesterification mechanism (0.001)
0.005
SPC24: Component of the evolutionarily conservedD[STH].[LDY]KI
0.005
L[LG]R[RID]G
44 [AG]R
member of a four-gene
Protease
family
matriptase
in S. cerevisiae,
protease
constitutively
site
expressed
0.005
[VEK]T.LL[TYI]
44interacts
DLL
with and is required
Binding
for activation
motif for
of clathrin
Apg1p protein
heavykinase;
chaininvolved
ear
in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway
0.005
Q[QEM].[QPW]I
44interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway
0.006
QE.[EQD]E[LVD]
0.005
RPP0: Conserved ribosomal protein P0 similar to rat
A[PAD]..[KYA]VV
Y
cytosolic large ribosomal subunit (sensu Eukaryota) (1e-04)
0.005
SAM1: S-adenosylmethionine synthetase, catalyzes[LEA]T.E[TGE]
of ATPCP[LP]T.E[ST].C
GM_CSF
methionine;
PATTERN
one of two differentially regulated isozymes (Sam1p and Sam2p)
0.009
FG[IE][NCE]
0.006
SOF1: Essential protein required for biogenesis of E[DKL].[SHM]AL
40S (small) ribosomal subunit; has
44 similarity to the beta subunit of trimeric G-proteins and the splicing
Y
factor Prp4p
0.005
[HCW]K..V[VCW]
44 that regulates growth in response to nutrients and TORC2, aYcomplex that regulates cell-cycle dependent polarization plasma
of the actinmembrane
cytoskeleton;(1e-04)
involved in meiosis
Y
0.005
GFA1: Glutamine-fructose-6-phosphate amidotransferase,
A..A[FDN]
catalyzes the formation44
of glucosamine-6-P
A.AA.VP....VP........P
and glutamate
PLU-1 transcription
from fructose-6-P
factor
andbinding
glutamine
motif
in the
infirst
BF-1
step
and
of chitin
PAX9biosynthesis
amino acid metabolism (1e-04)
Y
0.008
DI..[LCN][EPS]D
44 Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.005
SE.[KVD][EQG]N
[ST]E
enzyme
G protein-coupled
complexes
0.005
PRK1: Protein serine/threonine kinase; regulates the S[PD]SR[SG]
organization and function of the
44 actinSP
cytoskeleton through
ERK1,
the phosphorylation
ERK2 Kinaseofsubstrate
the Pan1p-Sla1p-End3p
motif
protein complex
0.005
M[SCT]..[SPG]SL
44 the
RSSLHL
U3 snoRNA that isMotif
involved
in beta-arrestin
in processing 2
of for
pre-18S
interaction
rRNA with Jnk3
0.005
VS.L[SMT][DWF]
0.005
YCK1: Palmitoylated, plasma membrane-bound casein kinase
SA[NDH]
44 [EDA][DE][ED][ED]S[EDA][DEA][ED][ED]
Casein
in morphogenesis,
Kinase II substrate
proper septin
motifassembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p
0.008
SRB2: Subunit of the RNA polymerase II mediator[NFP]N..[QAL]QQ
complex; associates with core polymerase
44
subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
general RNA polymerase II transcription factor activity (1e-05)
0.005
SRB2: Subunit of the RNA polymerase II mediator complex;
E[EMR]..SL[LN]
44
0.005
UTP8: Nucleolar protein required for export of tRNAsD[TAK]LL[TA]
44 with
LLTP
WD40processome
domain ofcontaining
Cdc4 binding
the U3motif,
snoRNA
Thrthat
must
is involved
be phosphorylated,
in processing ofCPD
pre-18S
motif
0.005
PIL1: Primary component of eisosomes, which are [KNR]DDD[DVY]
44 associated
DDDD..S
with endocytosis;
Caseinnull
kinase
mutants
1 phosphorylation
show activation ofmotif
Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
0.006
L[LWF]..[AVH]EK
44
to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
0.005
LR..[RTA][LYA]K
Rpl7Bp
LRT
and has similarity LKB1
to E. coli
Kinase
L30 and
substrate
rat L7 ribosomal
motif proteins; contains a conserved C-terminal Nucleic acid Binding
cytosolic
Domain (NDB2)
0.005
[LK]R[DCH]F
44 KR
in the degradation ofCLV_PCSK_PC1ET2_1
ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainlyproteasome
complex the
(sensu
cell cycle
Eukaryota) (1e-04)
0.006
CKB1: Beta regulatory subunit of casein kinase 2, a [SDY]D[SEM]D
44 in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription
RNA elongation
factors andfrom
all RNA
RNA
polymerases
0.008
N[LVS]S[LSK]N
44bindsS[ST]
proteins and DNA,MDC1
involvedBRCT
in regulation
domain
of many
binding
processes
motif including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
0.006
[KSQ]K[SKE]K
44manyKKKKKK[ST]
processes includingTGF
glycogen
betametabolism,
receptor kinase
sporulation,
substrate
and mitosis;
motif interacts with multiple regulatory subunits; predominantly isolated with Sds22p
0.008
KAP123: Karyopherin beta, mediates nuclear import
[EQK]E.GK[KAF]
assembly
G[KR][KR]
into ribosomes and
Amidation
import of histones
after cleavage
H3 and H4;
afterlocalizes
Gly (must
to thebe
nuclear
in secretory
pore, nucleus,
pathway)
and cytoplasm; exhibits genetic interactions with RAI1
0.005
KAP123: Karyopherin beta, mediates nuclear import
L[FSR].AK[PAQ]
assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibitssnRNP
protein import
with RAI1
into nucleus (0.01)
0.005
ARB1: ATPase of the ATP-binding cassette (ABC) family
KK[LTW][RQA]A
involved in 40S and 60S 44
ribosome
KKKLPATGDYMNMSPVGD
biogenesis, has similarity
Insulin receptor
to Gcn20p;kinase
shuttles
substrate
from nucleus
Ymotif
to cytoplasm, physically interacts with Tif6p, Lsg1p
0.005
RPS17B: Ribosomal protein 51 (rp51) of the small (40s)
AK[AVK][KAR]V
Rps17Ap and has similarity to rat S17 ribosomal protein
Y
0.005
[LQS][NSC]EC
44 [ST]E
G protein-coupled
and in chromatin receptor
modification,
kinase
similar
1 to
substrate
histone H2A
motif
SAGA complex (0.01)
0.005
D[DQI]E[EVL]
44RNAS[LW]LD[DE]EL[LM]
and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have
nucleolus
been yet identified
(1e-18) in higher eukaryotes
Y
0.008
I[LS].K[VKY]V
44
0.005
[IKW]V[KDR]A
guanyltransferase),
44 synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wallcytosol
structure(0.001)
Y
0.009
V[AK].[EGD]AA
guanyltransferase),
0.005
CSM1: Nucleolar protein that forms a complex with[GSV]G..G[SDG]A
Lrs4p which binds Mam1p at kinetochores
44
during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
0.005
S[GK]AK[GND]
0.005
RFA1: Subunit of heterotrimeric Replication ProteinK[VNK]V[DTF]S
A (RPA), which is a highly conserved
44 single-stranded DNA binding protein involved in DNA replication,
Y
repair, and recombination
0.005
oshea_cytoplasm
F[FLR]F[FLV]
0.008
[SPT]L[LNS]D
44 LLDLL
Clathrin binding motif in AP1
spindle (1e-82)
0.011
SK..[SEH]
44 K..[ST]
spindle (1e-16)
0.011
matsuyama_Cytosol
D..[GSV]N
44 DDDD..S
Casein kinase 1 phosphorylation motif
cell septum (0.001)
Y
0.011
matsuyama_Cytosol
L.K[VEH]
44 G[SA]LNK
GDP-mannose binding motif in transporter
ATP binding (1e-08)
Y
0.011
YPT6: GTPase, Ras-like GTP binding protein involved inQ.[SED]Q
the secretory pathway, required
44 for
[ST]Q
fusion of endosome-derived
ATM kinase
vesicles
phosphorylation
with the late Golgi,
site maturation of the vacuolar carboxypeptidase Y; has similarity
DNAtometabolism
the human GTPase,
(1e-08)
Rab6
Y
0.008
nucleolus
[HG]R.G[RFC]
43 [AG]R
DEAD
1.E-19
-2.5
nucleolus (1e-30)
0.010
matsuyama_Cytosol
V[ANP]...S
43 VP
Interleukin converting enzyme protease Pkinase
1.E-05
-2.3
ATP binding (1e-08)
0.010
E[DEQ]..[EGK]E
43 maturation; functionally redundant with Ssf2p; member of the Brix family Brix
1.E-03
-2.2
nucleolus (1e-25)
0.008
mitotic cell cycle
S..E[DNEQ]
43 QPS..E
Phosphorylation motif in alpha 3A, alpha 6A,HEAT
alpha 7A Integrin
1.E-02
tails
-1.8
0.009
NAN1: U3 snoRNP protein, component of the small (ribosomal)
K..E[RDQ]
subunit (SSU) processosome
43
containing U3 snoRNA; required for the biogenesis of18S rRNA WD40
1.E-05
-1.8
0.008
[EIT]EE[EGY]
43biogenesis
EEEYF
EGFR kinase phosphorylation site (peptide screen)
DEAD
1.E-02
-1.6
nucleolus (1e-24)
Y
0.008
[NWY]DH[LHA]
Pkinase
1.E-07
-1.5
0.005
ribosome biogenesis
[TFD][GLS]SGK
43 SG.G
site
Helicase_C
1.E-18
-1.3
Y
0.010
L[ST]..SP[KNR]
43 involved
SP in connectingERK1,
nuclearERK2
microtubules
Kinasetosubstrate
SPB; interacts
motif
with Tub4p-complex
Kinesin and calmodulin;
1.E-02phosphorylated
-1.2 byspindle
Mps1p inpole
body (0.001)manner
Y
0.005
A.[IVE]L
tRNA-synt_2b
1.E-02
-1.1
Y
0.009
G[RH]TA[RQ]
43 maturation; functionally redundant with Ssf2p; member of the Brix family DEAD
1.E-05
-1.1
0.005
RVS167: Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p)
K[AIS]E
involved
43 in regulation
[VILMAFP]K.E
MOD_SUMOMOD_SUMO
endocytosis, and viability following starvation
HEATor osmotic stress;
1.E-02
homolog of
-0.9
mammalian
cellamphiphysin
cortex (1e-06)
0.008
T..[DNQ]E
43 PT..[DI]
FHA binding motif
Zn_clus
1.E-04
-0.8
0.009
T..[DNQ]E
43 PT..[DI]
FHA binding motif
Zn_clus
1.E-04
-0.8
0.009
morphogenesis
[PES]A..[PHY]P
43
Pkinase
1.E-03
-0.8
0.009
[PES]A..[PHY]P
43
Pkinase
1.E-03
-0.8
0.009
T[GRH]S[GIF]K
Helicase_C
1.E-06
-0.8
0.005
M phase
E[KDI]L
43 DLL
Binding motif for clathrin heavy chain ear MutS_III
1.E-05
-0.6
M phase (1e-22)
0.009
hydrolase activity
R.V
43 [RK].V.F
PPI binding sites
UCH
1.E-09
-0.5
Y
0.009
K[AQT]...L
43 is required for processing of pre-18S rRNA; has similarity to mammalian
Helicase_C
fibrillarin
1.E-03
-0.3
nucleolus (1e-43)
0.008
A.[LGK]V
43 the
RALAHGVRVL
U3 snoRNA that isMitochondrial
targetting
of pre-18S
motif inrRNA
hepititis C core
WD40
protein
1.E-02
-0.2
0.008
SD..[NM]K[ELQ] Ndc80 complex
43 SD.E
Casein kinaseinvolved
II substrate
in chromosome
motif
segregation,
Kinesin
spindle checkpoint
1.E-02
0.2
spindle
clustering
(1e-05)
0.005
[SNT][SYQ]..KSR
43 by prior attachment of SUMO to the substrate
Pkinase
1.E-03
0.5
Y
0.005
oshea_bud_neck
S..[EQY]L
43 S..[ED]
RhoGAP
1.E-06
0.7
0.008
E[LQN]..N
to DNA damage; 43
Septin
Rad9p; also interacts
1.E-02with ARS11 and plays
cellacortex
role in initiation
part (1e-04)
of DNA replication
0.008
N.T[ANS]
43 N.[TS]
HEAT
1.E-02
1.2
0.009
IFA38: Microsomal beta-keto-reductase; contains oleateF..[ILMV]G
43
MFS_1 high levels
1.E-07
1.2
transporter
phytosphingosine
activity
and medium-chain
(1e-11)
ceramides
Y
0.008
localization
LF[VGR][SIG]
43 LFG
Protease Papain substrate, a prototype cysteine
MFS_1
proteinase 1.E-02
1.4
Y
0.009
D[GDP]..K[VYW]
43 of small ribosomal subunit (SSU) processosome; orthologYof the humanWD40
U3-55k protein 1.E-04
1.4
0.007
G[LFI].[VFW]G
Sugar_tr
at high inorganic
1.E-03
1.4
0.008
HHT2: One of two identical histone H3 proteins (seeAI..D[DNE][EFI]
1.5
methylation,
nuclear chromatin
(0.001)
0.005
I[FLG]..L[AGM]
43double
L...I...[IL]
Corepressor
enhanced synthesis
nuclearofbox
repressible
motif binds
acid phosphatase
to nuclear
MFS_1
receptors
at high inorganic
1.E-06
1.6
0.008
SLT2: Serine/threonine MAP kinase involved in regulating
H[RYE].I[KFA]
wall integrity and progression through the cell cycle; regulated by the PKC1-mediated
1.E-05
3
kinase activity (0.001)
0.006
PE..[LIF][LGR]
43
Pkinase
1.E-27
3.3
Y
0.009
[GY][RH]TAR
44biogenesis
[AG]R
DEAD
1.E-05
SAS10: Component of the small (ribosomal) subunit[RDK]RSS[LAE]
44for pre-18S
[KR]RrRNa processing;
CLV_PCSK_KEX2_1
essential nucleolar protein that, when overproduced,
Pkinase
disrupts silencing
1.E-04
H[KHT]..S[SHN]
44 bodies
S[ST]
at late anaphase;MDC1
promotes
BRCT
mitotic
domain
exit bybinding
directly switching
motif on thePkinase
1.E-10
10
9
10
10
10
8
10
10
10
10
8
10
10
10
10
10
10
10
10
9
10
10
7
10
10
9
10
10
10
9
9
10
10
10
10
10
10
10
10
10
7
10
10
8
10
7
10
8
10
10
9
10
10
9
10
8
7
9
9
8
8
10
10
10
7
10
9
9
8
9
9
10
9
8
9
9
8
8
10
10
10
10
8
10
9
8
8
10
7
10
8
8
9
8
10
10
10
10
10
10
10
10
10
10
10
10
9
10
9
10
8
10
10
10
10
10
8
10
10
10
10
8
8
10
10
10
10
10
10
10
8
10
9
10
protein_40_YNL061W
yeast-685_GO-0016740
yeast-462_GO-0019222
yeast-410_GO-0007049
yeast-462_GO-0019222
yeast-437_GO-0044429
yeast-341_GO-0045449
yeast-324_GO-0030528
yeast-251_GO-0005886
yeast-235_GO-0009653
yeast-235_GO-0000902
yeast-217_GO-0007046
yeast-216_GO-0006325
yeast-216_GO-0006323
protein_40_YPR144C
protein_40_YPR144C
protein_40_YPL213W
protein_40_YPL198W
protein_40_YPL093W
protein_40_YNR054C
protein_40_YNR054C
protein_40_YNL118C
protein_40_YMR047C
protein_40_YML085C
protein_40_YML069W
protein_40_YML048W
protein_40_YML007W
protein_40_YLR180W
protein_40_YLL008W
protein_40_YKR026C
protein_40_YKL203C
protein_40_YJR066W
protein_40_YJR002W
protein_40_YJL138C
protein_40_YJL092W
protein_40_YJL081C
protein_40_YJL074C
protein_40_YIL144W
protein_40_YIL095W
protein_40_YIL061C
protein_40_YHR197W
protein_40_YHR052W
protein_40_YHR052W
protein_40_YGR218W
protein_40_YGR086C
protein_40_YGL195W
protein_40_YGL112C
protein_40_YGL051W
protein_40_YFR052W
protein_40_YFR010W
protein_40_YFL037W
protein_40_YER177W
protein_40_YER146W
protein_40_YER133W
protein_40_YER133W
protein_40_YER102W
protein_40_YDR303C
protein_40_YDR145W
protein_40_YDR145W
protein_40_YDR091C
protein_40_YDR060W
protein_40_YDL185W
protein_40_YDL015C
protein_40_YBR200W
protein_40_YBR017C
oshea_spindle_pole
matsuyama_Microtubule
matsuyama_Golgi
genetic_YLR200W
genetic_YGL058W
genetic_YGL058W
genetic_YEL003W
genetic_YAL024C
protein_40_YBR160W
protein_40_YDL153C
protein_40_YLR029C
protein_40_YDR060W
yeast-376_GO-0019219
protein_40_YPL043W
protein_40_YHR052W
protein_40_YPR016C
protein_40_YLL008W
protein_40_YMR229C
yeast-251_GO-0005886
oshea_bud_neck
protein_40_YBR106W
yeast-1115_GO-0006996
yeast-312_GO-0006414
protein_40_YGR086C
yeast-413_GO-0005215
yeast-1974_GO-0005634
yeast-295_GO-0016192
oshea_bud_neck
yeast-410_GO-0007049
yeast-413_GO-0005215
protein_40_YGR128C
protein_40_YBR106W
yeast-256_GO-0016462
yeast-244_GO-0000279
protein_40_YDL140C
protein_40_YNR054C
yeast-205_GO-0005856
protein_40_YER125W
protein_40_YPL031C
protein_40_YHR082C
yeast-267_GO-0044265
yeast-256_GO-0016462
protein_40_YNL272C
protein_40_YOR181W
matsuyama_Cytosol
protein_40_YKR048C
protein_40_YGL207W
protein_40_YNL186W
protein_40_YGR103W
protein_40_YNL272C
yeast-345_GO-0006396
protein_40_YLR002C
yeast-685_GO-0016740
yeast-238_GO-0017111
protein_40_YNL272C
protein_40_YMR229C
protein_40_YGL105W
protein_40_YNL061W
yeast-685_GO-0016740
yeast-939_GO-0051234
yeast-792_GO-0006412
yeast-628_GO-0043037
yeast-324_GO-0030528
yeast-235_GO-0009653
yeast-235_GO-0000902
yeast-205_GO-0005856
yeast-1721_GO-0016043
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
[PNR][TH].IQ
43 ofGIQVD
27S pre-rRNA anddynein
large ribosomal
light chain
subunit
LC8biogenesis;
interactinglocalized
motif -alternative
to the
DEAD
1.E-04
3.6
cytoplasm
particles
0.006
9
[GAH]L.Y[LMC]H
43 Y[VLTFIC]
LIG_SH2_STAT5
Pkinase
1.E-24
4.7
Y
0.010
10
KR[KRY]
43 KR
CLV_PCSK_PC1ET2_1
Zn_clus
1.E-07
4.8
0.009
10
H..[ILF]KP
43
Pkinase
1.E-27
4.8
cell cycle (1e-31)
0.009
10
[ASW][CDI]..CR
43 C..C
Zn_clus
1.E-26
19.1
0.010
10
mitochondrial part
T.[SFQ]S
43 T..[SA]
0.009
10
[RI]KFLL
43
0.006
8
S[ENT][EGM]E
43 S[DE][DE]E
BARD1 BRCT domain binding motif
Y
0.009
10
plasma membrane
[IGH]FG[LTQ]
43 FGRA
DNA binding motif in ssDNA binding proteins
0.010
9
morphogenesis
T[VRD]..A[AW]T
43
0.006
9
T[VRD]..A[AW]T
43
0.006
9
ribosome biogenesis
EK.N[AMH][LFP]
43 KEN
LIG_APCC_KENbox_2
0.006
7
[QMW]Q..[SLK]K
43
Y (1e-42) 0.010
10
DNA packaging
[QMW]Q..[SLK]K
43
Y (1e-42) 0.010
10
[LMR]ISI[LDF]
and nuclear
RR.SI
PKA kinase
subunits
phosphorylation site (peptide screen)
0.005
8
D[TAK]LL[TAI]
and nuclear
LLTP
WD40 domain
subunitsof Cdc4 binding motif, Thr must be phosphorylated, CPD motif
Y
0.005
9
LEA1: Component of U2 snRNP; disruption causes[DQF]P[SRV]LN
reduced U2 snRNP levels; physically
43 P[ST]
interacts with Msl1p;DNA
invovled
dependent
in telomere
Protein
maintenance;
kinase putative
substrate
homolog
motif of human U2A' snRNP protein
spliceosome (1e-09)
0.005
8
[AKM]R...K
Rpl7Ap
R...K..R
and has similarity Motif
to E. coli
in Ebola
L30 and
virus
rat L7
that
ribosomal
eliminates
proteins;
Y IFN-beta
contains
production
a conserved C-terminal Nucleic acid Binding
cytosolic
Domain (NDB2)
0.008
10
K[KLV]..G[IK]
43
and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN
cytoplasm
family of nucleolar
organization
G-proteins
0.008
10
ESF2: Essential nucleolar protein involved in pre-18S
[EAM]E.[EQY]K
rRNA processing; component
43of the small subunit (SSU) processome; has sequence similarity
Y to mABT1, a mouse transcription activator
nucleolus (1e-14)
Y
0.008
10
ESF2: Essential nucleolar protein involved in pre-18SA[FCM]..[KY]I
43of the small subunit (SSU) processome; has sequence similarity to mABT1, a mouse transcription activator
nucleolus (1e-07)
0.005
9
D[HCF].[FPN]Q
43
cytoplasmic mRNA processing body (0.001)
0.005
8
R[SLP].S[KWR]K
of the KKR..S
Phosphorylation
GLFG motif that
siteinteracts
for MLCK
with Y
mRNA export factor Mex67p and with karyopherin Kap95p;nuclear
homologous
pore
to organization
Nup100p
Y
0.004
9
[KG]K.S[SYQ]D
43 polymerizes
RKK.[ST]
to form microtubules
Y
0.005
9
[SWH]R[VC]E
which facilitates
43 RNA Pol II transcription elongation through nucleosomes by destabilizing
Y
and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p)
0.005
8
GSF2: ER localized integral membrane protein that TL[GHI][TAN]G
may promote secretion of certain
43 hexose
PLTLP
transporters, including
RAF1 Gal2p;
kinaseinvolved
substrate
in glucose-dependent
motif
repression
Y
0.005
7
YAP1: Basic leucine zipper (bZIP) transcription factor
TT[SNT]V[NMQ]
RNA
mediates
polymerase
resistance
II to
transcription
cadmium
mediator activity (0.01)
0.005
9
SAM1: S-adenosylmethionine synthetase, catalyzesK[ITH]SI[KGQ]
of ATPRKK.[ST]
ZIP
methionine;
one of two differentially
motif regulated isozymes (Sam1p and Sam2p)
0.005
8
RTL[LNS][ITY]
including
R.L
Cyclin A motif
subunits;
thatconstituent
binds cdk2
of 66S
complexes
Ypre-ribosomal particles
0.005
9
GCN3: Alpha subunit of the translation initiation factor
AG[LCA][DYM]
eIF2B, the guanine-nucleotide
43 exchange
G[GA]G[ASC][FY]S.K[DE]
factor for eIF2;ADOMET_SYNTHETASE_2
activity subsequently regulated by
PATTERN
phosphorylated eIF2; first identified as a positive regulator of
eukaryotic
GCN4 expression
translation initiation factor 2B complex (0.001)
0.006
7
I[YMI]S[ARD]L
43 thatIYregulates growth incFGR
response
andtoCsk
nutrients
kinase
andphosphorylation
TORC2, a complex
site
that
(peptide
regulatesscreen)
cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis
Y
0.005
10
TOR1: PIK-related protein kinase and rapamycin target;AS..[SEG]
43 thatYASI
controls growth in SHP2
response
phosphatase
to nutrients by
substrate
regulatingmotif
translation, transcription, ribosome biogenesis, nutrient transport
plasma
and autophagy;
membrane
involved
(1e-20)
in meiosis
Y
0.008
10
MPP10: Component of the SSU processome, which[AYN]L[LKG]TI
43 GTALL
interacts with and
Receptor
controls recycling
the stabilitymotif
of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
0.005
9
K[EID][FLG]EG
43 that
IEGR
couples ATPase activity
Protease
to RNA
Protease
binding and
Factor
unwinding;
X a forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
Y
0.005
7
SRS2: DNA helicase and DNA-dependent ATPase SS[SDG][PRM]F
involved in DNA repair, needed43
0.005
9
DQ.[VIR][TRF]
0.005
8
Q[QYS].[VR]N
43
in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved
cohesin
SMC chromosomal
complex (1e-06)
ATPase family member
0.006
9
L[ETS].[EAQ]TE Ndc80 complex
43 [ST]E
G protein-coupled
conserved
receptor
coiled-coil
kinase
protein
1 substrate
involved in
motif
chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
0.004
9
PRK1: Protein serine/threonine kinase; regulates the
EK..L[EGY][DQY]
43 actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex
0.005
10
SNP1: Component of U1 snRNP required for mRNAL[REF][LEN]PF
interact
NPF
EH EFtohand
regulate
domain
polyadenylation;
binding motif,
homolog
Class
of human
I
U1 70K protein
0.005
8
[RSC]G..I[PY]
43for processing
IY
of ITS2 sequences
cFGR and
from
Csk
35Skinase
pre-rRNA;
phosphorylation
Rix1 complex
Y
associates
site (peptide
with screen)
Mdn1p in pre-60S ribosomal particles
0.005
9
[GQV]K[IAV]LG
0.005
8
E[ETN]E[EWM]
43 role
[ST]E
G protein-coupled
specificity; alsoreceptor
copurifies
kinase
with 66S
1 substrate
pre-ribosomal
motif
particles
0.008
10
[SN]GG[LT]F
43 from
GGQ
the nucleus
N-methylation motif in E. coli, Gln
Y residue in methylated, mimics CCA motif at the end
snRNP
of tRNA
protein
molecule
0.005
7
[ECL]KLS[TKP]
43 associated
S[ST] with endocytosis;
MDC1 null
BRCT
mutants
domain
showbinding
activation
motif
of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
0.005
10
GCN1: Positive regulator of the Gcn2p kinase activity,
[ICK]T.D[AHM]
forms a complex with Gcn20p;
43 proposed to stimulate Gcn2p activation by an uncharged tRNA
0.006
8
[VRP]LE[YFQ]L
43 L..[LM]E
of RNA polymerase Sec24pSec24pSec24p
II and in chromatin modification, similar
Y to histone H4
SLIK (SAGA-like) complex (0.01)
0.005
8
MST27: Putative integral membrane protein, involved
[YCM][GAW]RR
in vesicle formation; forms complex
43 [AG]R
with Mst28p; member
Protease
of DUP240
matriptase
gene family;
protease
binds COPI
site and COPII vesicles
0.004
7
RPN12: Subunit of the 19S regulatory particle of the 26S
[ST][AK]VAS
proteasome lid; synthetically
43 lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
0.005
9
UBP6: Ubiquitin-specific protease situated in the base
DE[AGN]K[EW]
subcomplex of the 26S proteasome,
43 YDE[PDV]
releases free ubiquitin
SH2from
ligand
branched
for Nck1
polyubiquitin
and Nck2
chains;
(Tyr must
deletion
becauses
phosphorylated)
hypersensitivity to cycloheximide and other toxic compounds
Y
0.005
9
[KW]Y..[TVA]F
43dimer,
Y..[LIV]
which polymerizesJAK2
to form
autophosphorylation
microtubules
signalY
Y
0.005
9
[QLP]F[KAF]SK
0.005
9
[RIA][DQT].ILT
possiblyxinvolved
U5 tri-snRNP
in processing
complex
tRNA, snoRNA,
(0.01) and rRNA
0.005
8
EK..[RAS]A[LM]
43manyK..[ST]
processes includingPKA
glycogen
kinase
metabolism,
substratesporulation,
motif
and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
0.005
7
KK..G[EIF][IYK]
43manyRKK.[ST]
processes includingZIP
glycogen
kinase
metabolism,
phosphorylation
sporulation,
motif
and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
0.005
9
K[LID].A[KFV]R
43 and[KR]R
has similarity to rat CLV_PCSK_KEX2_1
S8 ribosomal protein
0.005
10
RSC3: Component of the RSC chromatin remodeling[SHK]II[NSK]N
43 forSYII
RAD9
ploidy
BRCT
and domain
regulationbinding
of ribosomal
motif
Y protein genes and the cell wall/stress response; highly similar
RSCtocomplex
Rsc30p (0.001)
0.005
10
[DRN]I[STW]M
43 WM
Substrate
and in chromatin
binding motif
modification,
of barley
similar
alpha-amylase
to histone H2A1 (AMY1) enzyme
0.006
10
Q[QKR]Q[LST]
43
Y
0.009
10
RLI1: Essential iron-sulfur protein required for ribosome
AE..[DAW][DHA]
biogenesis and translation43
initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted
cytosolic
ABC
ribosome
family ATPase
0.007
10
MAK21: Constituent of 66S pre-ribosomal particles, required
AR..[ARY]
for large (60S) ribosomal
43 subunit
[AG]R
Protease
in nuclear
matriptase
export of
protease
pre-ribosomes;
site required for maintenance of dsRNA virus; homolog of cytoplasm
human CAATT-binding
organization
proteinand biogenesis (1e-14)
0.008
10
TFP1: Vacuolar ATPase V1 domain subunit A containing
E[LKH]..L[QKG]T
the catalytic nucleotide binding
43 sites;
[IV]DLGT[ST].[SC]
protein precursor
HSP70_1
undergoes
PATTERN
self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
0.005
7
TSC13: Enoyl reductase that catalyzes the last step inM[LMP].[LT]I
each cycle of very long chain
43fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p
0.005
7
BEM1: Protein containing SH3-domains, involved in
DK.[QSA]L[DQV]
establishing cell polarity and morphogenesis;
43
functions as a scaffold protein for complexes thatYinclude Cdc24p, Ste5p, Ste20p, and Rsr1p
cytokinesis, site selection (0.001)
0.004
10
KAP104: Transportin, cytosolic karyopherin beta 2 involved
SGG[LFT]F
43 nuclear
[ED]GSG[DE]
ribonucleoproteins
Glycosaminoglycan
to the nucleoplasm,
attachment
binds rg-nuclear
site localization signals on Nab2p and Hrp1p, plays a role
snRNP
in cell-cycle
protein
progression
0.005
8
oshea_spindle_pole
EI..[LHY][KGQ]
43
microtubule cytoskeleton (1e-22)
0.009
10
D[MF]..[SFT]SG
43
Y
spindle (1e-05)
0.006
7
ENG[SPD][PAM]
43 GP
spindle (1e-09)
Y
0.008
10
KT..[KHM][DGK]L
43
0.006
9
matsuyama_Golgi
I[VIF].[ICA]I
43
Y
0.011
10
YKE2: Subunit of the heterohexameric Gim/prefoldinYF[NW]D[SYC]
protein complex involved in the
43folding of alpha-tubulin, beta-tubulin, and actin
Y
0.005
8
RAD6: Ubiquitin-conjugating enzyme (E2), involved in postreplication
E..[KQF]K repair (with Rad18p),
43
sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)
Y
0.008
10
N.N
repair (with Rad18p),
43
0.008
10
E[LNQ]E
specifically
KENto cytosolic chaperonin
LIG_APCC_KENbox_2
and transfers target proteins to it
establishment of organelle localization (1e-07)
Y
0.008
10
LTE1: Putative GDP/GTP exchange factor required for mitotic
S.[PQH]S
exit at low temperatures;
43 acts
SGHSL
14-3-3-zeta
exchange
binding
factor motif
(GEF)in
forplatelet
Tem1p, adhesion
which is a key
receptor,
regulator
glycoprotein
of mitotic exit;
(GP)
physically
Ib-IX associates
cell cycle
with Ras2p-GTP
(1e-20)
0.008
10
V.[KNY]R
43
Pkinase
the CDK to specific
1.E-02
substrates-0.2
cell cycle (1e-06)
0.008
10
SAS10: Component of the small (ribosomal) subunitPR[TNG][TFH]
42for pre-18S
LVPRG
rRNa processing;
Protease
essential
Thrombin
nucleolar protein that, when overproduced,
Pkinase
disrupts silencing
1.E-09
-1.7
Y
0.005
8
[VLD][AQ]..GLD
to Rpl15Bp
[AC]GL.FPV
and has similarity
HISTONE_H2A
to rat L15 ribosomal
PATTERN
protein; binds to 5.8 S rRNA
DEAD
1.E-05
-1.4
0.005
9
MAK21: Constituent of 66S pre-ribosomal particles, G[RQY][TMK]A
42 subunit
G[KR][KR]
Amidation
in nuclear
afterexport
cleavage
of pre-ribosomes;
after Gly (must
required
be DEAD
for
in secretory
maintenance
pathway)
of 1.E-05
-1.4 of ATP-dependent
human CAATT-binding
RNA
protein
0.007
10
S..[TQE]T
acid metabolism
42 S..[ST]
must first be -1.2
phosphorylated)
Y
acid metabolism
0.009 (1e-20)
10
[HA]R..R[TI]A
and large
R.[RK]R
ribosomal subunit
CLV_PCSK_FUR_1
biogenesis; constituent of 66S pre-ribosomal particles;
RNA recognition
-1.2
motifs (RRMs)
Y
0.005
8
VAA[RA][GWH]
-1.2
Y
0.005
10
TIF6: Constituent of 66S pre-ribosomal particles, has similarity
K.[KQE]R
to human translation
42initiation
[KR]R
factor 6 (eIF6); may
CLV_PCSK_KEX2_1
be involved in the biogenesis andYor stability of 60S
Brixribosomal subunits
1.E-02
-1.1
Y
0.007
10
[ALI]R..DI[PW]
including
[AG]R
Proteasesubunits;
matriptase
constituent
protease
of 66S
sitepre-ribosomal
DEAD
particles
1.E-03
-1
0.005
8
RRP5: Protein required for the synthesis of both 18STG[SPL][GIA]K
42 is[SAG]GGTG[SA]G
TUBULIN
of 18S PATTERN
rRNA and N-terminal region is required
Helicase_C
component of -0.9
small ribosomal
helicase
subunit
activity
(SSU) (1e-08)
processosome
Y
0.006
10
plasma membrane
WG
42 [DE]AT..[DE]PWG[PA]
PI(4,5)P2 binding motif in epsin
MFS_1
1.E-07
-0.7
0.009
10
oshea_bud_neck
[NRH]I.Q[NPV]
42
PH
1.E-04
-0.6
Y
0.009
10
F..A[VTI]
MFS_1
at high inorganic
1.E-10
-0.4
Y
0.008
10
VN[HDP]
42 Y[VI]N
SH2 ligand for Grb2 in IRS-1, EGFR, and
PI3_PI4_kinase
Shc
1.E-03
-0.3
Y
0.009
10
[TWN]V[KRW]A
42
Ribosomal_60s
1.E-02
-0.2
0.006
9
[AHY][SFN]LSK
42 associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p
Cpn60_TCP1
stress resistance1.E-02
pathways; detected
-0.1 in phosphorylated state in mitochondria
0.004
9
I..G[LAI]
42
Y
MFS_1
1.E-09
0.1
Y
0.009
10
nucleus
I..[KNE]N
42
Y
SMC_N
1.E-03
0.1
0.009
10
vesicle-mediated transport
Q..[LST]Q
42 [ST]Q
SNARE
1.E-05
0.3
vesicle-mediated transport (1e-13)
0.009
10
oshea_bud_neck
P.I[PNR]
42 PWI
Motif in SRM160 for binding DNA and RNARhoGAP
1.E-03
0.3
Y
0.008
10
cell cycle
S.[KDT]R
42 RRK.S.KR
PKCgamma kinase phosphorylation site (peptide
MutS_III
screen) 1.E-02
0.6
cell cycle (1e-18)
0.009
10
A.[LFG]L
42 LMA[EQ]GLYN ENGRAILED PATTERN
Mito_carr
1.E-16
1
Y
0.009
10
UTP8: Nucleolar protein required for export of tRNAs
GS.[GDI]G[FNL]
42 with
[ED]GSG[DE]
Glycosaminoglycan
processome containing
attachment
the U3site
snoRNA that WD40
1.E-02
of pre-18S1.1
0.005
7
I[AYG]..[GIA]F
42double
IYnull mutant exhibits
cFGR
enhanced
and Csk
synthesis
kinase
of repressible
phosphorylation
acid phosphatase
site MFS_1
(peptide
at high
screen)
inorganic
1.E-05
1.6
Y
0.009
10
SA..[GLP][EN]
42
ABC_tran
1.E-08
1.8
0.009
10
M phase
E[FES]L[NSK]
42
MutS_III
1.E-04
1.8
M phase (1e-09)
Y
0.009
10
RPO21: RNA polymerase II largest subunit B220, part
YR.P[ELK][LIT]
42 of Y..P
SH2repeat
liganddomain
groupregulates
1B-Crk, association
SH2 binding
withmotif
transcription
Pkinase
for ITK,and
Nck
splicing
and1.E-05
RasGAP
factors; similar
to Doc-R
1.8
to bacterial
(needs
protein
beta-prime
to be
serine/threonine
Tyr phosphorylated)
0.004
7
ESF2: Essential nucleolar protein involved in pre-18S rRNA
[IPA]K.WD
processing; component
42of thePWDLW
small subunit (SSU)
processome; has sequence similarity to mABT1, WD40
a mouse transcription
1.E-02
activator
1.9
0.005
8
cytoskeleton
[LWD]A[GVH]SE
42 [ST]E
G protein-coupled receptor kinase 1 substrate
Kinesin
motif
1.E-08
2.1
0.006
9
RSP5: Ubiquitin-protein ligase involved in ubiquitin-mediated
K[IA]AD[FLG]
functions in multivesicular body sorting, heat shock response and ubiquitylation
Pkinase
of arrested RNAPII;
1.E-03
contains a hect
2.1(homologous
protein
to E6-AP
kinasecarboxyl
activity
terminus)
(0.01)domain
0.005
9
PHO85: Cyclin-dependent kinase, with ten cyclin partners;
AK..[NR]D[SH]
42cellular response to nutrient levels and environmental conditions and progression
Cyclin_N
through the cell
1.E-04
cycle
2.2
cyclin-dependent protein kinase regulator activity (0.01)
0.005
9
KSP1: Nonessential putative serine/threonine protein
[LGF]K.[QED]N
kinase of unknown cellular role;
42 overproduction
[VILAFP]K.E
causes Motif
allele-specific
recognized
suppression
for modification
of the prp20-10
by SUMO-1
mutation
Pkinase
1.E-04
2.3
0.008
10
cellular macromolecule catabolism
G[NTY].[VS]IQ
42
Y
PUF
1.E-07
2.5
mRNA catabolism (1e-07)
0.005
9
I[PIV][VFL]I
42 RRRRSIIFI
DEAD
1.E-04
2.6
Y
0.009
10
I[TWN].[FIC]G
Pkinase
1.E-10
2.7
Y
0.006
10
LAS17: Actin assembly factor, activates the Arp2/3A[EPG]..D[EVD]L
branched actin filaments; localizes with the Arp2/3 complex to actin
Y patches; homolog
SH3_1 of the human
1.E-03
Wiskott-Aldrich
2.8syndrome protein (WASP)
Y
0.005
8
matsuyama_Cytosol
D..[SAC]L
42 DDDD..S
Casein kinase 1 phosphorylationYmotif
Pkinase
1.E-06
2.9
ATP binding (1e-09)
Y
0.010
10
R[DMW].K[PQ]
1.E-10
and H2B histones
3 to the
protein
nucleus;
kinase
phosphorylated
activity by
(1e-10)
CK2
0.006
8
SPT16: Subunit of the heterodimeric FACT complex [ATD]D[FYD]G
Pkinase
1.E-07
nucleosome
3 structure
Y
0.008
10
UBP10: Ubiquitin-specific protease that deubiquitinates [YLD]..PE
Pkinase
Gap1p and 1.E-29
3.1
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-29)
Y
0.008
10
NOP7: Nucleolar protein involved in rRNA processing
P[NAV]..KS[SQE]
and 60S ribosomal subunit biogenesis;
42 S[ST]
constituent of several
MDC1different
BRCTpre-ribosomal
domain binding
particles;
motifrequiredMMR_HSR1
for exit from G0
1.E-03and the 3.1
initiation of
ribosome
cell proliferation
biogenesis (0.001)
0.005
7
K[PSI][EDS]N
Pkinase
1.E-24
3.4
0.008
10
RNA processing
I[VIM]..TP[GP]
42 [ST]P
LIG_WW_4LIG_WW_4
DEAD
1.E-11
3.5
0.007
9
DEA[DAI][RL]
3.5
RNA
factorshelicase
and replication
activity
initiation
(1e-04)
0.004
7
IK..[NAM][LI]
42
Pkinase
1.E-27
3.7
Y
(1e-40)0.009
10
DE.[DCT][RAS]
42 LPDEL
Motif in CBP for interaction with Y
PPARg-LBD AAA
(secondary site)1.E-13
3.7
Y
0.010
10
[LIW]K.[EDQ]N
42cytoplasmic
[VILAFP]K.E
vesicles; essential
Motif recognized
for post-Golgifor
vesicle
modification
transport by SUMO-1
Pkinase
1.E-29
3.9
Y
0.008
10
RRP5: Protein required for the synthesis of both 18SK[PAF].N[LIF]L
42 is crucial for the formation of 18S rRNA and N-terminal region is required
Pkinase
component of small
4.2 ribosomal
protein
subunit
kinase
(SSU)
activity
processosome
(1e-16)
0.007
10
D.W[SAR]
synthetases (Mes1p
42 and
PWDLW
Gus1p), deliveringLIG_Clathr_ClatBox_2
tRNA to them, stimulating catalysis, and ensuring
Pkinase
the cytoplasm; 4.6
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-19)
Y
0.008
10
R.[GKA]R
42 of[AG]R
27S pre-rRNA andProtease
large ribosomal
matriptase
subunitprotease
biogenesis;
site
localized to
Helicase_C
the nucleolus; constituent
1.E-05
5.4
cytoplasm
particles
Y
0.008
10
G..P[FWY]
42 [ILVM]LG..P
LIG_RRM_PRI_1
Pkinase
1.E-44
7.2
Y
(1e-52)0.009
10
LF[VGR][SGI]
42 LFG
Protease Papain substrate, a prototype cysteine proteinase
0.009
10
D[DKS]N
42 Y.D.NHKPE
PMI_I_1 PATTERN
0.009
10
translation
[AEK]AA[KR]K
42
translation (1e-18)
0.009
10
RHN[LRW][SIL]
42
0.007
10
morphogenesis
Q[SEN]..[VSQ]N
42
0.009
10
Q[SEN]..[VSQ]N
42
0.009
10
cytoskeleton
IR.E[KPR][IDK]
42 [DET]E[RK].PL[LI]
TRG_LysEnd_APsAcLL_3
0.005
9
LD.[SLI][IAQ]
42 DALDL
14-3-3 binding motif in ExoS
Y
0.009
10
cell cycle
protein_40_YPL204W
2 HRR25: Protein kinase involved in regulating diverse[LR]G[ETH]LE
42
DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
0.004
8
protein_40_YPL141C
2 FRK1: Putative protein kinase; similar to Kin4p; green
D[EDF]..[EFL]E
fluorescent protein (GFP)-fusion
42 protein localizes to the cytoplasm; YPL141C is not an essential gene
0.008
10
protein_40_YPL129W
2 TAF14: Subunit of TFIID, TFIIF, INO80, SWI/SNF, andN[IA].[NSD]NI
in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain
0.004
8
protein_40_YPL043W
2 NOP4: Nucleolar protein, essential for processing and
[LRY][RVQ]..KEL
and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal
Y
particles; contains four RNA recognition motifs (RRMs)
Y
0.004
7
protein_40_YOR326W
2 MYO2: One of two type V myosin motors (along with
[REK]LS[SAG]V
42transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes,
Rho
and
protein
the mitotic
signal
spindle
transduction (0.01)
Y
0.005
8
protein_40_YOR133W
2 EFT1: Elongation factor 2 (EF-2), also encoded by EFT2;
SE.[IFS]E[KAV]
catalyzes ribosomal translocation
42 [ST]E
G protein-coupled
contains diphthamide,
receptorthe
kinase
unique1 posttranslationally
substrate motif modified histidine residue specifically ADP-ribosylated by diphtheria toxin
Y
0.005
10
protein_40_YNL308C
2 KRI1: Essential nucleolar protein required for 40S ribosome
[FAT]G.A[RHC]
and functionally
FGRA interacts with
DNA
Krr1p
binding motif in ssDNA binding proteins
0.005
10
protein_40_YNL209W
2 SSB2: Cytoplasmic ATPase that is a ribosome-associated
NK.[TLA]D[ADL]
42
with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1
0.004
8
protein_40_YMR236W
2 TAF9: Subunit (17 kDa) of TFIID and SAGA complexes,
[NYM][SC]TQ
42 II transcription
S[QT]Q initiation and
ATMin phosphorylation
of this
similar
motiftoon
histone
Chk2H3
0.005
9
protein_40_YMR236W
[RAY]D[GCH]T
42 II transcription
Q[DEK]..[LIVMGTA][GA]DGT
initiation and
TCP1_3
in chromatin
PATTERN
modification, similar to histone H3
0.005
8
protein_40_YMR116C
2 ASC1: G-protein beta subunit and guanine nucleotide[EPF]E.[VPI]E
dissociation inhibitor for Gpa2p;
42 ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
0.008
10
protein_40_YLR293C
2 GSP1: GTP binding protein (mammalian Ranp homolog)
IIT[SQK][LAI]
42 of nuclear organization, RNA processing and transport; regulated by Prp20p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p
nuclear
and Kap95p;
transport
yeast(0.01)
Gsp2p homolog
0.005
8
protein_40_YLR186W
2 EMG1: Protein required for the maturation of the 18S
[RWE]H..[FIE]L
production; associated with spindle/microtubules; nuclear localization depends on physical interaction with Nop14p; may bind
snoRNA
snoRNAs
binding (1e-12)
Y
0.006
9
protein_40_YLR180W
2 SAM1: S-adenosylmethionine synthetase, catalyzes[TGA]G..[IDT]V
carboxylic acid metabolism (0.001)
Y
0.008
10
protein_40_YLR180W
2 SAM1: S-adenosylmethionine synthetase, catalyzesS[ECN].LE[AE]
0.005
7
protein_40_YLR166C
2 SEC10: Essential 100kDa subunit of the exocyst complex
K[VH][LI]SA
(Sec3p, Sec5p, Sec6p, 42
Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
0.005
10
protein_40_YLR029C
2 RPL15A: Protein component of the large (60S) ribosomal
K..[RAK]A
to Rpl15Bp
K[KR].[KR]
and has similarity
Nuclear
to rat L15
localization
ribosomal motif
Y
0.007
10
protein_40_YLL011W
2 SOF1: Essential protein required for biogenesis of 40S
A[EN][KRP]AL
42 similarity
DALDL
to the beta subunit
14-3-3
of trimeric
bindingG-proteins
motif in ExoS
and the splicing
Y
factor Prp4p
35S primary transcript processing (1e-05)
0.005
8
protein_40_YKR026C
2 GCN3: Alpha subunit of the translation initiation factor
A[KN].AA[SRM]
42 exchange factor for eIF2; activity subsequently regulated by phosphorylated
Y
eIF2; first identified as a positive regulator of GCN4 expression
0.005
10
protein_40_YKR001C
2 VPS1: Dynamin-like GTPase required for vacuolar sorting;
PA..[AKW][PTY]
also involved in actin cytoskeleton
42
organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis
establishment and/or maintenance of chromatin architecture (0.01) 0.006
9
protein_40_YKL180W
[RGW]A[AYI]R
to Rpl17Bp
[AG]R
and has similarity
Protease
to E. colimatriptase
L22 and rat protease
L17 ribosomal
siteproteins; copurifies with the Dam1 complex (aka DASH complex)
0.007
10
protein_40_YKL173W
2 SNU114: GTPase component of U5 snRNP involved
[TAV]G..[DRF]LK
in mRNA splicing via spliceosome;
42 binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal
mRNA
translocation
metabolism
factor(1e-06)
EF-2
0.005
9
protein_40_YKL104C
2 GFA1: Glutamine-fructose-6-phosphate amidotransferase,
[TYW]Q.[VHY]V
of glucosamine-6-P
[ST]Q
and glutamate
ATM kinase
from fructose-6-P
phosphorylation
and glutamine
site
in the first step of chitin biosynthesis
0.005
7
protein_40_YJR123W
2 RPS5: Protein component of the small (40S) ribosomal
A[AKG]..[KAR]A
subunit, the least basic of the
42 non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal
cytosolic
proteinsribosome (sensu Eukaryota) (1e-25)
Y
0.008
10
protein_40_YJL203W
2 PRP21: Subunit of the SF3a splicing factor complex,LRE[ENK][IG]
42
0.004
7
protein_40_YJL074C
2 SMC3: Subunit of the multiprotein cohesin complex[KMP]T..V[KNR]
required for sister chromatid cohesion
42
Y
0.007
10
protein_40_YIL133C
2 RPL16A: N-terminally acetylated protein component IA.S[RT][RYK]
42 S[ST]
binds to 5.8 S rRNA;
MDC1
has similarity
BRCT to
domain
Rpl16Bp,
binding
E. coli motif
L13 and rat L13a ribosomal proteins; transcriptionally regulated
ribosome
by Rap1p(0.001)
0.004
8
protein_40_YIL075C
2 RPN2: Subunit of the 26S proteasome, substrate ofL[ADI].[GML]GE
the N-acetyltransferase Nat1p42
EGGELGY
PHOSPHOKETOLASE_1 PATTERN
proteasome regulatory particle (sensu Eukaryota) (0.01)
0.005
8
protein_40_YHR152W
2 SPO12: Nucleolar protein of unknown function, positive
[QV]Y..[SE]V
regulator of mitotic exit; involved
42 in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis
0.005
9
protein_40_YHR140W
2 YHR140W: Putative integral membrane protein of unknown
V[LVD]..LV[LAH]
function
42
0.005
9
protein_40_YHR135C
PTI isoform; shares redundant
42 LPTSY
SMAD
in morphogenesis,
interacting motifproperFM1
septininassembly,
motif for endocytic
binding in
trafficking;
XFoxH1provides an essential function overlapping with that of Yck2p
0.008
10
protein_40_YHR010W
KK.[KAL][KAS]
to Rpl27Bp
K[KR].[KR]
and has similarity
Nuclear
to rat L27
localization
ribosomal motif
protein
Y
0.008
10
protein_40_YGR218W
2 CRM1: Major karyopherin, involved in export of proteins,
[KER]K.[EKF]E
42 from
KTKEGC
the nucleus
Repeating motif in alpha-synuclein that binds apolipoproteins
Y
0.008
10
protein_40_YGR086C
2 PIL1: Primary component of eisosomes, which are large
KQ[KVE][LSN]E
42 associated
[ST]E with endocytosis;
G protein-coupled
null mutants show
receptor
activation
kinase
of Pkc1p/Ypk1p
1 substrate stress
motif resistance pathways; detected in phosphorylated
SWR1 complex
state in(0.001)
mitochondria
0.005
9
[IAQ]D..R[NLA]S
42and has
R.Ssimilarity to E. coli
PKA
L2 kinase
and rat L8
substrate
ribosomalmotif
proteins
0.004
8
protein_40_YFL002C
2 SPB4: Putative ATP-dependent RNA helicase, nucleolar
R[KAV].A[KLV]E
42 of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
nucleolus (1e-04)
0.005
7
protein_40_YER082C
[SAI]S..LA[INE]
0.005
8
protein_40_YER082C
VG.[SK]T[RI]
0.005
7
protein_40_YEL037C
2 RAD23: Protein with ubiquitin-like N terminus, recognizes
T[IPS].NV[KC]
42(with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins
0.005
10
protein_40_YDR471W
2 RPL27B: Protein component of the large (60S) ribosomal
[KLG]G.KV[TK]
to Rpl27Ap and has similarity to rat L27 ribosomal protein
0.004
8
protein_40_YDR450W
2 RPS18A: Protein component of the small (40S) ribosomal
E[SIG]..EE[GHK]
to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
preribosome (0.001)
0.005
9
protein_40_YDR356W
2 SPC110: Inner plaque spindle pole body (SPB) component,
S[VHR]..DS[VLD]
42 involved in connecting nuclear microtubules to SPB; interacts
Y with Tub4p-complex and calmodulin; phosphorylated bynuclear
Mps1p inchromosome
partmanner
(0.001)
Y
0.004
8
protein_40_YDR224C
2 HTB1: One of two nearly identical (see HTB2) histoneN[EFH]T[PC]
42
assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.005
8
protein_40_YDR172W
2 SUP35: Translation termination factor eRF3; alteredA[SWY][LV]EK
protein conformation creates 42
the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype
0.005
8
protein_40_YDL185W
2 TFP1: Vacuolar ATPase V1 domain subunit A containing
[ID]N..PS[LP]
42 sites;
SPSP
protein precursor
Motif
undergoes
for hydroxylation
self-catalyzed
ofsplicing
Prolinetoresidues,
yield the extein
whichTfp1p
can and
further
the intein
be modified
Vde (PI-SceI),
with arabinogalactan
which is a site-specific endonuclease
0.005
9
protein_40_YDL148C
2 NOP14: Nucleolar protein, forms a complex with Noc4p
N[RVS]D[TQR]L
42 nuclear
DLLexport of 40S ribosomal
Binding subunits;
motif for also
clathrin
present
heavy
in the
chain
smallear
subunit processome complex, which is required for processing
processing of pre-18S
of 20SrRNA
pre-rRNA (0.001)
0.005
7
protein_40_YDL140C
2 RPO21: RNA polymerase II largest subunit B220, part
[ST]N..NL[IWP]
42 of C-terminal heptapeptide repeat domain regulates association
Y with transcription and splicing factors; similar to bacterial
RNA
beta-prime
polymerase II transcription elongation factor activity (0.01)
0.005
9
protein_40_YDL083C
2 RPS16B: Protein component of the small (40S) ribosomal
[KNL][GY].KVT
42 and has similarity to E. coli S9 and rat S16 ribosomal proteins
Y
0.005
10
protein_40_YDL055C
2 PSA1: GDP-mannose pyrophosphorylase (mannose-1-phosphate
DG.[TSA][SCR]A
guanyltransferase),
Y
0.005
10
protein_40_YDL055C
VA[YFC][GVA]
guanyltransferase),
42 synthesizes
DVAD GDP-mannose
Protease
from GTP
Caspase
2 -stringent
Y
0.007
10
protein_40_YBR159W
2 IFA38: Microsomal beta-keto-reductase; contains oleate response
I.F[VMG]
element (ORE) sequence
42 [RK].[VI].F
in the promoter region;
PP1 protein
mutants phosphatase
exhibit reducedsubstrate
VLCFA synthesis,
recognition
accumulate
motif high levels of dihydrosphingosine,endoplasmic
phytosphingosine
reticulum
and medium-chain
(1e-07)ceramides
0.008
10
protein_40_YBR159W
2 IFA38: Microsomal beta-keto-reductase; contains oleate
LV.G[FMR][QSP]
42
in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
0.004
8
protein_40_YBL026W
2 LSM2: Lsm (Like Sm) protein; part of heteroheptameric
N[PRW].[GC]W
either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA
Y decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.005
8
protein_40_YAL032C
2 PRP45: Protein required for pre-mRNA splicing; associates
IQ..[NC][TEA]
Y
0.005
10
protein_40_YAL032C
K[RLQ]K
42 interacts
KRKQISVR
Phosphorylase
Prp22p and kinase
Prp46p;substrate
orthologousmotif
to human transcriptional coactivator SKIP and can activate
nuclear
transcription
mRNA
of asplicing,
reporter gene
Y
0.008
10
protein_40_YAL032C
KA..[QIM][FHN]
Y
0.007
10
PP[SAF][SHR]
42
Y
Y
0.011
10
genetic_YNL153C
2 GIM3: Subunit of the heterohexameric cochaperone prefoldin
D.I[GNL]
to it
cell cycle (1e-11)
0.008
10
genetic_YLR200W
2 YKE2: Subunit of the heterohexameric Gim/prefoldin[LMV]G..[LK]DG
42folding
Q[MLVI]DG..[DE]
of alpha-tubulin, beta-tubulin,
CLV_TASPASE1
and actin
Y
0.005
8
genetic_YLR200W
2 YKE2: Subunit of the heterohexameric Gim/prefoldin protein
R.L[KSE]
complex involved in the
42folding
R.L
Cyclin A motif
and that
actin binds cdk2 complexes
cell cycle (1e-09)
0.008
10
genetic_YLR200W
S[TDQ]N
42folding
S[ST]
MDC1 BRCT
anddomain
actin
binding motif
0.007
10
genetic_YLR039C
2 RIC1: Protein involved in retrograde transport to the cis-Golgi
E..D[ERT]
network; forms heterodimer
42
with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.008
10
genetic_YGL058W
2 RAD6: Ubiquitin-conjugating enzyme (E2), involved in
[SPW]K[DVK]D
postreplication repair (with Rad18p),
42
DNA metabolism (0.001)
Y
0.008
10
protein_40_YPR103W
2 PRE2: Beta 5 subunit of the 20S proteasome, responsible
E[YQL].LE[ASD]
Y
Proteasome
1.E-11
-3.1
proteasome core complex (sensu Eukaryota) (1e-11) Y
0.004
8
protein_40_YGR103W
2 NOP7: Nucleolar protein involved in rRNA processing
KR..[VEK][EKN]
41 KR constituent of several
CLV_PCSK_PC1ET2_1
different pre-ribosomal particles; required for exit
Brixfrom G0
1.E-02and the-2.3
initiation of
cytoplasm
cell proliferation
0.008
10
yeast-376_GO-0019219
2 regulation of nucleobase, nucleoside, nucleotide andH[TS].E[KRN]P
41
zf-C2H2
1.E-20
-1.2
0.009 (1e-14)
10
yeast-345_GO-0006396
2 RNA processing
TG.[GMV]K[TV]
41 TGY
ERK6/SAPK3 activation sites forYHOG/p38
Helicase_C
activation
1.E-21
-1.2
0.009
10
oshea_bud_neck
2 oshea_bud_neck
S..[PTF]Q
41 [ST]Q
RhoGAP
1.E-05
-1.2
0.008
10
yeast-504_GO-0006350
2 transcription
LP[PKT]
41 LPKY
WW motif (non-conventional ) inYspt23 for binding
Zn_clus
to WW domain
1.E-06
of RSP5p,
-1.1
also for
transcription
NEDD4 WW(1e-25)
domain
0.009
10
yeast-200_GO-0006519
2 amino acid and derivative metabolism
[LIC][VGA].SG
41 KSGST
eIF4 motif phosphorylation motifY
GATase
1.E-02
-1.1
0.009
10
protein_40_YOR272W
2 YTM1: Constituent of 66S pre-ribosomal particles, required
K[ESR]K[KVD]
41 ribosomal
KR subunit
CLV_PCSK_PC1ET2_1
Y
DEAD
1.E-02
-1.1
nucleolus (1e-22)
0.008
10
protein_40_YMR290C
2 HAS1: ATP-dependent RNA helicase; localizes to both
[HAR]R..R[TAD]A
41 R.[RK]R
highly enriched inCLV_PCSK_FUR_1
nuclear pore complex fractions; constituent of 66SDEAD
pre-ribosomal particles
1.E-05
-1.1
0.004
8
yeast-504_GO-0006350
2 transcription
TT[AND]
41 [DGH][IVSAC]T[ST]NP[STA][LIVMF][LIVMF]
TRANSALDOLASE_1 PATTERN
Zn_clus
1.E-05
-1
Y
0.009
10
protein_40_YPL043W
[AIL]R..D[IA]P
and large
[AG]R
ribosomal subunit
Protease
biogenesis;
matriptase
constituent
protease
site
particles;
RNA recognition-1motifs (RRMs)
0.005
8
protein_40_YKL009W
2 MRT4: Protein involved in mRNA turnover and ribosome
[RML][GS].DIP
nucleolus
S.D
CAMKII phosphorylation site
DEAD
1.E-03
-0.9
0.005
7
yeast-312_GO-0006414
GK[STN][TP]
41 K[ST]P.K
GSK-3, ERK1, ERK2, CDK5 substrate
Y
GTP_EFTU_D2
motif
1.E-05
-0.8
0.006
9
yeast-235_GO-0009653
2 morphogenesis
AP..[VPN][SFT]
41 P..P
SH3 general ligand,
SH3_1
1.E-02
-0.8
0.009
10
yeast-235_GO-0000902
AP..[VPN][SFT]
41 P..P
SH3 general ligand,
SH3_1
1.E-02
-0.8
0.009
10
yeast-1074_GO-0044428
2 nuclear part
D..[TDR]K
41
Helicase_C
1.E-03
-0.8
Y
0.009
10
yeast-388_GO-0007275
2 development
[ASN][QTK]..KS
41
RasGEF_N
1.E-02
-0.6
0.009
10
protein_40_YOL133W
2 HRT1: RING finger containing subunit of Skp1-Cullin-F-box
AI[DEC]
conjugating enzyme
-0.6 or E2)
protein
and Cdc53p
catabolism
(a cullin)(1e-04)
subunits of SCF
Y
0.008
10
protein_40_YMR047C
2 NUP116: Subunit of the nuclear pore complex (NPC) that
D..[GLD]D
is localized to both sides41
of the D..G
motif that
GLFG
binds
motif phosphate
that interactsinwith
GDP
mRNA
andexport
GTPIBN_N
factor
binding
Mex67p
proteins
and1.E-05
with karyopherin
-0.6
Kap95p;nuclear
homologous
transport
to Nup100p
(1e-24)
Y
0.007
10
protein_40_YER110C
2 KAP123: Karyopherin beta, mediates nuclear import
SE.[SVQ]E[NDT]
assembly
[ST]E
into ribosomes and
G protein-coupled
import of histones H3
receptor
and H4;kinase
localizes
1 substrate
to the nuclear
Sec7
motif
pore, nucleus,
1.E-02
and cytoplasm;
-0.5
exhibitsmRNA-binding
genetic interactions(hnRNP)
with RAI1 protein import into nucleus (0.01)
0.004
7
yeast-1062_GO-0016020
2 membrane
S..L[TIF]
41
Y
MFS_1
1.E-03
-0.3
0.008
10
matsuyama_Cytosol
2 matsuyama_Cytosol
E.[LAK]T
41
Pkinase
1.E-03
-0.3
ATP binding (1e-07)
Y
0.010
10
protein_40_YLR276C
2 DBP9: ATP-dependent RNA helicase of the DEAD-box
[ETG]EE[EDG]
41of theEED
60S ribosomal subunit
Ankyrin B C-terminal motif that binds
Y internal Brix
0
nucleolus (1e-18)
0.008
10
protein_40_YPR144C
2 NOC4: Nucleolar protein, forms a complex with Nop14pK..K[LRK]
and nuclear
CLV_PCSK_PC1ET2_1
subunits
WD40
1.E-05
0.1
nucleolus (1e-37)
Y
0.007
10
protein_40_YOL069W
S[ERL].NS[SLK] Ndc80 complex
41 S[ST]
MDC1 BRCT involved
domain inbinding
chromosome
motif segregation,
SMC_N
spindle checkpoint
1.E-02
0.1
clustering
0.005
9
yeast-213_GO-0009719
2 response to endogenous stimulus
L[SER]T[QHI]
41 LRT
Y
SMC_N
1.E-04
0.3
0.008
10
protein_40_YJL081C
2 ARP4: Nuclear actin-related protein involved in chromatin
[LMN]A..[AE]AR
[AG]R
enzyme
Protease
complexes
matriptase protease site
Histone
1.E-04
0.4
9
yeast-244_GO-0000279
2 M phase
L..N[KNS]
41
Y
MutS_III
1.E-03
0.5
M phase (1e-20)
Y
0.009
10
protein_40_YBR159W
I..[VFL]Ielement (ORE) sequence
41
MFS_1 high levels
1.E-05
0.6
transporter
phytosphingosine
activity
and medium-chain
(1e-09)
ceramides
0.008
10
matsuyama_Nucleus
2 matsuyama_Nucleus
F[LFA]F
41 A[EA]EEY[FV]F[LFMIV]F
FGFR kinase substrate motif
MFS_1
1.E-06
0.6
0.010
10
matsuyama_Spindle_or_SPB 2 matsuyama_Spindle_or_SPB
L.[RQS]S
41
Y
Pkinase
1.E-02
0.8
spindle (1e-19)
Y
0.010
10
yeast-238_GO-0017111
[ATR]L..E[LIS]
41
AAA
1.E-08
0.9
Y
0.009
10
protein_40_YLR340W
2 RPP0: Conserved ribosomal protein P0 similar to ratE[EVQ].K[EGI]E
Ribosomal_60s
1.E-07
0.9
0.006
10
genetic_YLR262C
2 YPT6: GTPase, Ras-like GTP binding protein involved inGN[DSE]
41 for
[LIVMA]G[EQ]HG[DN][ST]
L_LDH PATTERN
vesicles with the late Golgi, maturation
Myb_DNA-binding
of the vacuolar carboxypeptidase
1.E-02
Y;0.9
has similarity
chromatin
to the human
modification
GTPase, Rab6
(1e-10)
0.007
10
protein_40_YGR103W
[DGN]L..L[LRG]P
41 L..LL
Motif different
for interaction
pre-ribosomal
with nuclear
particles;receptors,
required fordocking
exit
Brixfrommotif
G0
for 1.E-02
p300 on
and
p53
theto
1.1
initiation
promote
of
cytoplasm
cell
acetylation
proliferation
Y
0.005
8
protein_40_YGR275W
2 RTT102: Component of both the SWI/SNF and RSCVL..[LPN]A[AD]
41 suggested role in chromosome maintenance; possible weak regulator ofHistone
Ty1 transposition 1.E-02
1.2
0.005
7
protein_40_YCL059C
2 KRR1: Essential nucleolar protein required for the synthesis
I[KHC].W[DCT]
WD40
1.E-07
1.3
0.005
8
protein_40_YBR010W
2 HHT1: One of two identical histone H3 proteins (see
RL.[RTD]R[GAL]
41 for[KR]R
chromatin assembly,
CLV_PCSK_KEX2_1
involved in heterochromatin-mediated
Y telomericHistone
1.4
methylation,
nuclear nucleosome
(0.001)
Y
0.004
8
yeast-610_GO-0031090
2 organelle membrane
G[LVA].[FAI]G
41
Mito_carr
1.E-09
1.5
envelope (1e-29)
0.008
10
protein_40_YER110C
2 KAP123: Karyopherin beta, mediates nuclear importSS.I[ARK][ANG]
assembly
S[ST]
into ribosomes and
MDC1
importBRCT
of histones
domain
H3 and
binding
H4; localizes
motif to the nuclear
Sec7pore, nucleus,
1.E-02
and cytoplasm;
1.6
exhibits genetic interactions with RAI1
0.004
10
protein_40_YLL008W
[LAP]LK[AHK]L
including
LLKIL
AP-2 binding
subunits;
motif
constituent
in CXCR2
of 66S
receptor
pre-ribosomal
Pkinase
particles
1.E-02
2.1
0.006
10
protein_40_YGR128C
2 UTP8: Nucleolar protein required for export of tRNAs[DET]K.[VTD]K
1.E-05
of pre-18S2.1
0.008
10
yeast-1939_GO-0003824
[DEQ]T[AID]GQ
41
Ras
1.E-36
2.7
0.009
10
protein_40_YAR019C
FG[SLF][ACW]
1.E-16
3
0.006
8
protein_40_YPL211W
2 NIP7: Nucleolar protein required for 60S ribosome subunit
GK.A[AL][FKP]
DEAD
3.1
0.005
9
protein_40_YNL272C
2 SEC2: Guanyl-nucleotide exchange factor for the smallY..[PMW]E
41cytoplasmic
Y..[ILM]
vesicles; essential
SH2 ligand
for post-Golgi
FOR Shc
vesicle
group
transport
3 (phospho-peptide)
Pkinase
Syk also 1.E-26
3.2
Y
0.008
10
protein_40_YOL127W
2 RPL25: Primary rRNA-binding ribosomal protein component
IA[TK][PMS]G
41 subunit,
KSGSThas similarity
eIF4
to E.motif
coli L23
phosphorylation
and rat L23a ribosomal
motif proteins; binds
DEAD
to 26S rRNA via
1.E-05
3.6
RNA
0.004
8
protein_40_YNL061W
2 NOP2: Probable RNA m(5)C methyltransferase, essential
[TCF]PG[RW]
41 of[ST]P
27S pre-rRNA andLIG_WW_4LIG_WW_4
large ribosomal subunit biogenesis; localized to the
DEAD
1.E-07
4
ribosomal
particles large subunit assembly and maintenance (1e-08)
0.004
10
protein_40_YOL127W
2 RPL25: Primary rRNA-binding ribosomal protein component
[TRF][GNY].GKT
41 subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds
DEAD
to 26S rRNA via
1.E-09
4.2
RNA
0.005
9
yeast-1389_GO-0044260
2 cellular macromolecule metabolism
HRD[ILMV][KLS]
MGMT PATTERN
Pkinase
1.E-55
6.9
0.009
10
yeast-544_GO-0016070
2 RNA metabolism
[HFG]R.G[RFW]
41 RGG
Alternative integrin binding site in
Y FMDV virus
Helicase_C
1.E-23
10.9
0.009
10
yeast-294_GO-0006366
2 transcription from RNA polymerase II promoter
[CFA]R.[RKD]K
41 R.RKGSF
PKC delta kinase substrate motifY
Zn_clus
1.E-11
13.3
0.009
10
yeast-460_GO-0006351
2 transcription, DNA-dependent
CR.[RKT][KWH]
41 R.[ST]
PKA consensus phosphorylation site
Zn_clus
1.E-21
17.9
0.009
10
yeast-589_GO-0050896
2 response to stimulus
[LPV]E.P[KMR]
41 [ST]P[KR]
Growth associated histone HI kinase substrate motif
response to stress (1e-24)
Y
0.009
10
yeast-388_GO-0007275
2 development
K[NIM]K[NMH]
41
0.009
10
yeast-320_GO-0006355
2 regulation of transcription, DNA-dependent
Q[VMS]L[LTP]
41
0.009
10
yeast-295_GO-0016192
2 vesicle-mediated transport
SL..[LVE][PQH]
41
Y
0.009
10
yeast-251_GO-0005886
2 plasma membrane
C..[SYF]G
41
Y
Y
0.009
10
yeast-248_GO-0031966
2 mitochondrial membrane
S..S[DHN]
41 S..S
Casien kinase I phosphorylation site, 1st Ser must be phosphorylated
0.009
10
yeast-235_GO-0009653
2 morphogenesis
Q..[SQN]H
41
Y
0.009
10
yeast-235_GO-0000902
Q..[SQN]H
41
Y
0.009
10
yeast-223_GO-0003735
2 structural constituent of ribosome
T[ETV]T
41 YTV
14-3-3 domain binding motif
0.009
10
yeast-219_GO-0046903
2 secretion
D[FHV]L[LIW]K
41 LLKIL
AP-2 binding motif in CXCR2 receptor
secretion (1e-13)
0.007
10
yeast-1547_GO-0043283
2 biopolymer metabolism
KF[GKN]
41 KFG.GDG
NMT_2 PATTERN
0.009
10
yeast-1134_GO-0044249
A[AGQ].[KER]A
41
Y
macromolecule biosynthetic process (1e-33)
0.009
10
yeast-1134_GO-0044249
E..[NQC]E
41
Y
0.009
10
yeast-1036_GO-0005739
2 mitochondrion
D[EDS]D
41 D[SGDN]D[PE][LIVMF]D[LIVMGAC]
PPASE PATTERN
Y
cell cycle (1e-15)
0.009
10
protein_40_YPL146C
2 NOP53: Nucleolar protein; involved in biogenesis of [EWF]IL[RIP]S
the 60S subunit of the ribosome;
41 interacts
LLKIL
with rRNA processing
AP-2 binding
factors Cbf5p
motif and
in CXCR2
Nop2p; null
receptor
mutant is viable but growth is severely impaired
Y
0.004
8
protein_40_YPL129W
2 TAF14: Subunit of TFIID, TFIIF, INO80, SWI/SNF, and
[LVK]A[ENH]LI
in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain
0.004
9
protein_40_YPL090C
R[RGA].A[RQM]
41 and has similarity to rat S6 ribosomal protein
0.007
10
protein_40_YOR310C
2 NOP58: Protein involved in pre-rRNA processing, 18S
SE[SVT][EGM]S
41synthesis; component of the small subunit processome complex,
Y which is required for processing of pre-18S rRNA
nucleolus (1e-08)
0.005
9
protein_40_YOR181W
2 LAS17: Actin assembly factor, activates the Arp2/3 [PMN]E..[RAM]Y
Y patches; homolog of the human Wiskott-Aldrich syndrome
endocytosis
protein (WASP)
(0.01)
Y
0.005
protein_40_YOR039W
2 CKB2: Beta' regulatory subunit of casein kinase 2, aSN.[GP]G[NHK]
41 in cell growth and proliferation; the holoenzyme also containsYCKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
0.005
protein_40_YOL012C
2 HTZ1: Histone variant H2AZ, exchanged for histone[YMG][EPW]EV
41 complex;
[YW]EVD
involved in transcriptional
Protease Caspase
regulation
1 /ICE
through prevention of the spread of silent heterochromatin
protein_40_YNL209W
2 SSB2: Cytoplasmic ATPase that is a ribosome-associated
[AFP]S.KA[IDV]
41
with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1
0.004
protein_40_YNL154C
PP[PHN]K[PN]
41 [DE]FPPP
EVH
in morphogenesis,
binding motif of
proper
Mena
septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p
0.004
protein_40_YMR290C
2 HAS1: ATP-dependent RNA helicase; localizes to both
[DKQ]D.[EGK]E
41
highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
0.008
protein_40_YMR236W
[EMV]DE[DNV]E
41 II transcription
S[DE][DE]E
initiation and
BARD1
in chromatin
BRCT modification,
domain binding
similar
motif
to histone H3
0.006
protein_40_YMR139W
2 RIM11: Protein kinase required for signal transductionE[KT][LHN]IN
41
the formation of the Ime1p-Ume6p complex by phosphorylating
Y
Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta
0.005
protein_40_YMR012W
2 CLU1: eIF3 component of unknown function; deletion
R[ETP]..[IQG]P
causes defects in mitochondrial
41 organization
GP
but not in growth
Protease
or translation
TTP cleavage
initiation,
site
can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
0.006
protein_40_YML085C
2 TUB1: Alpha-tubulin; associates with beta-tubulin (Tub2p)
SS..[LEN]N[KWQ]
41 polymerizes
S[ST] to form microtubules
Y
0.004
protein_40_YLR429W
2 CRN1: Coronin, cortical actin cytoskeletal componentSS..[IK][LP]N
41 S[ST]
complex to regulate
MDC1
its activity;
BRCT
plays
domain
a rolebinding
in regulation
motifof actin patch assembly
0.004
protein_40_YLR347C
2 KAP95: Karyopherin beta, forms a dimeric complex with
[IVS]G.G[LA]F
Srp1p (Kap60p) that mediates
41 nuclear
SG.Gimport of cargoGlycosaminoglycan
proteins via a nuclearattachment
localization signal
site (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex
0.005
protein_40_YLR347C
2 KAP95: Karyopherin beta, forms a dimeric complexGG.[FAS][GHF]S
with Srp1p (Kap60p) that mediates
41 nuclear
GGQimport of cargoN-methylation
proteins via a nuclear
motif inlocalization
E. coli, Gln
signal
residue
(NLS),ininteracts
methylated,
with nucleoporins
mimics CCA
to guide
motiftransport
at the end
across
protein
of tRNA
theimport
nuclear
molecule
into
pore nucleus
complex (1e-05)
0.004
protein_40_YKL203C
2 TOR2: PIK-related protein kinase and rapamycin target;
I[LTE]..IL[PEQ]
41 that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization actin
of the actin
cytoskeleton
cytoskeleton;
organization
involved in meiosis
and biogenesis (0.001) Y
0.004
protein_40_YKL145W
2 RPT1: One of six ATPases of the 19S regulatory particle
[DYQ]MI[LQG]
41 YM
in the degradation ofSH2
ubiquitinated
ligand for
substrates;
Vav1 (group
required
II) (phospho-peptide)
for optimal CDC20 transcription; interacts with Rpn12p and the
proteasome
E3 ubiquitin-protein
complex
ligase
(sensu
Ubr1p Eukaryota) (0.001)
Y
0.005
protein_40_YJL130C
2 URA2: Bifunctional carbamoylphosphate synthetase[TV]V[AYM]AL
(CPSase)-aspartate transcarbamylase
41 DALDL
(ATCase), catalyzes
14-3-3
the first
binding
two enzymatic
motif in ExoS
steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
0.005
protein_40_YJL130C
2 URA2: Bifunctional carbamoylphosphate synthetaseED[AR]D[DKA]
41 D.D
(ATCase), catalyzes
Ribose
the first
moiety
two enzymatic
of UDP and
stepsmanganese
in the
Yde novobinding
biosynthesis
site inofglucuronyl
pyrimidines;transferase
both activities are subject to feedback inhibition by UTP
0.005
protein_40_YJL081C
K[LQ]..N[VFA]T
protein_40_YJL074C
2 SMC3: Subunit of the multiprotein cohesin complex required
[EDV]V.[EMI]I
41
in mitotic cells; also required, with Rec8p, for cohesion and
Y recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
Y
0.007
protein_40_YJL010C
2 NOP9: Essential component of pre-40S ribosomes E[SDQ]..[EGP]E
that is required for early cleavages
41 of 35S pre-rRNA and hence formation of 18S rRNA; binds RNA in vitro and contains multiple pumilio-like repeats
nucleolus (1e-24)
0.008
protein_40_YIL094C
[EMP]K.[FH]V
0.005
protein_40_YIL094C
[SY]TYA[DA]
41 for[LN][RI]TY
PDGFR
biosynthesis
kinaseofsubstrate
lysine, in which
motifhomo-isocitrate
Y
0.005
protein_40_YIL094C
A[KAY]..E[REG]
Y
0.008
protein_40_YHR196W
T[NL]..DD[NYK]
41 the
DDDK[ACDEFGHIKLMNQRSTVWY]
U3 snoRNA that isProtease
involved in
Enterokinase
processing of pre-18S rRNA
nucleolus (0.01)
0.005
protein_40_YHR148W
2 IMP3: Component of the SSU processome, which is[RWE]H..[FIE]L
41
essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA nucleolus (1e-13)
Y
0.006
protein_40_YHR135C
KT[GKS]
41 [FY]PS[AGMS]CGKT[NS]
PEPCK_GTP
in morphogenesis,
PATTERN
proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p
0.008
protein_40_YHR088W
2 RPF1: Nucleolar protein involved in the assembly ofI[SGV]..LR[DTN]
the large ribosomal subunit; constituent
41 LRT
LKB1
particles;
Kinasecontains
substrate
a sigma(70)-like
motif
motif, which is thought to bind RNA
0.004
protein_40_YHR052W
2 CIC1: Essential protein that interacts with proteasome
[KQC]KS[LV]E
0.005
protein_40_YGR252W
[LSG]K.V[PLQ]T
41 H3; VP
Interleukin
ADA and SAGA
converting
histone
enzyme
acetyltransferase
proteasecomplexes; founding member of the Gcn5p-related N-acetyltransferase superfamily
0.004
protein_40_YGR252W
L[IHW].[DC]AI
41 H3; EDAIY
AblADA
kinase
and SAGA
substrate
histone
motif
acetyltransferase complexes; founding member of the Gcn5p-relatedSAGA
N-acetyltransferase
complex (0.01)
superfamily
0.005
protein_40_YGR218W
EE.[KLA]S[SLK]
41 from
EED
the nucleus
0.006
protein_40_YGR218W
G[NFT].N[TKN]
41 from the nucleus
Y
0.008
protein_40_YGR218W
2 CRM1: Major karyopherin, involved in export of proteins,L..Q[LPR]
41 from the nucleus
Y
0.007
protein_40_YGR103W
[DER][EGN]EE
41 EEEYF
EGFRdifferent
kinasepre-ribosomal
phosphorylation
particles;
siterequired
(peptide
forscreen)
exit from G0 and the initiation of
cytoplasm
cell proliferation
Y
0.008
protein_40_YGR103W
[KHR]K..K[ARQ]
41 KR constituent of several
CLV_PCSK_PC1ET2_1
different pre-ribosomal particles; required for exit from G0 and the initiation of
cytoplasm
cell proliferation
Y
0.008
protein_40_YGR103W
E[DEP]..D[EGM]
41
constituent of several different pre-ribosomal particles; required for exit from G0 and the initiation of
cytoplasm
cell proliferation
Y
0.008
protein_40_YGR090W
2 UTP22: Possible U3 snoRNP protein involved in maturation
SD[DYE][EHQ]
41on computational
S[DE][DE][DE]
analysis
Casein
of large-scale
Kinaseprotein-protein
II substrate motif
interaction data
0.007
protein_40_YGR086C
[KPI]RRS[LEV]
41 associated
[KR]R with endocytosis;
CLV_PCSK_KEX2_1
null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
0.005
protein_40_YGL158W
2 RCK1: Protein kinase involved in the response to oxidative
SS[DQY]D[EKQ]
stress; identified as suppressor
41 S.D
of S. pombe cell cycle
CAMKII
checkpoint
phosphorylation
mutations site
0.005
protein_40_YGL147C
[RIW]AA[RS]
Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
0.007
protein_40_YGL111W
2 NSA1: Constituent of 66S pre-ribosomal particles, involved
G[FP]..V[TMN]
41biogenesis
GP
0.005
protein_40_YGL105W
2 ARC1: Protein that binds tRNA and methionyl- and[LGV]K..[TEM]LT
41 and
K..[ST]
Gus1p), deliveringPKA
tRNAkinase
to them,
substrate
stimulating
motif
catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
Y
0.005
protein_40_YGL076C
T[KDP][KSP]GL
Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins;
Y
contains a conserved C-terminal Nucleic acid Binding
ribosomal
Domain (NDB2)
large subunit biogenesis (1e-04)
0.005
protein_40_YFR034C
[IGD]G[APC]R
41 [AG]R
with Pho2p to the
Protease
PHO5 promoter;
matriptase
function
protease
is regulated
site by phosphorylation at multiple sites and by phosphate availability
Y
0.008
protein_40_YFL039C
2 ACT1: Actin, structural protein involved in cell polarization,
[EHT]LE[SEV]T
cytoskeletal
L..[LM]E
functions
Sec24pSec24pSec24p
response to osmotic stress (0.001)
0.005
protein_40_YER172C
2 BRR2: RNA-dependent ATPase RNA helicase (DEIH[LKF]KL[ER]S
box); required for disruption 41
of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.004
protein_40_YER133W
2 GLC7: Catalytic subunit of type 1 serine/threonine protein
E.[VDG]D
41manyYE.[IV]
processes includingSH2
glycogen
ligand
metabolism,
for Fes (Tyr
sporulation,
must beand
phosphorylated)
mitosis; interacts with multiple regulatory subunits; predominantly
mRNA cleavage
isolated with
and
Sds22p
polyadenylation specificity factor complex (1e-08)0.008
protein_40_YER006W
2 NUG1: GTPase that associates with nuclear 60S pre-ribosomes,
L[EWL].I[NGH]N
required for export
Y
nucleolus (0.01)
0.004
protein_40_YDR449C
T[DKL].SK[RK]
41 the
KRU3 snoRNA that isCLV_PCSK_PC1ET2_1
involved in processing of pre-18S rRNA
0.004
protein_40_YDR388W
2 RVS167: Actin-associated protein, subunit of a complexP.[RQS]E
41 in regulation
[ST]E of actin cytoskeleton,
G protein-coupled
endocytosis,
receptor
and viability
kinase
following
1 substrate
starvation
motif
or osmotic stress; homolog of mammalian
cellamphiphysin
cortex (1e-04)
0.007
protein_40_YDR303C
2 RSC3: Component of the RSC chromatin remodeling
Q[DWM].D[SDP]
41 forP.Q..D
LIG_TRAF2_2
ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p
0.005
protein_40_YDR225W
2 HTA1: One of two nearly identical (see also HTA2) histone
[SCI]I[LE]SP
41 required
SP for chromatinERK1,
assembly
ERK2
and chromosome
Kinase substrate
function;
motif
DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.005
protein_40_YDR174W
2 HMO1: Chromatin associated high mobility group (HMG)
[IKA]S..F[SQY]I
41genome
S..F
maintenance; rDNA-binding
LIG_BRCT_BRCA1_1
component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
Y
0.004
protein_40_YDR064W
2 RPS13: Protein component of the small (40S) ribosomalR..[VAK]R
subunit; has similarity to E.
41coli S15
[KR]R
and rat S13 ribosomal
CLV_PCSK_KEX2_1
proteins
Y
0.008
protein_40_YDR060W
2 MAK21: Constituent of 66S pre-ribosomal particles,[NVY]E..SD[SVA]
41 subunit
YE biogenesis; involved
TPK-IIB/P38Syk
in nuclear export
kinase
of pre-ribosomes;
phosphorylation
required
sitefor
(peptide
maintenance
screen)
of dsRNA virus; homolog of nucleolus
human CAATT-binding
(1e-06) protein
0.004
protein_40_YDR012W
[LAR]G.K[AKV]
Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins
Y
0.008
protein_40_YDL213C
2 NOP6: Putative RNA-binding protein implicated in ribosome
[KNG]K.K[KVQ]
41RNAP.[ST]PKK.KK
Cdc2and
likehas
protein
similarity
kinase
to hydrophilins;
substrateNOP6
motif may be a fungal-specific gene as no homologs have
nucleolus
been yet identified
Y
0.008
protein_40_YDL213C
EE[SLV]S[GFK]
41RNAYEE[IV]
SH2 and
ligand
has group
similarity
1A,
to Src
hydrophilins;
FGR SH2
Y NOP6
domain
may be
(needs
a fungal-specific
to be Tyr phosphorylated)
gene as no homologs have
RNA
been
metabolism
yet identified (1e-05)
in higher eukaryotes
0.005
protein_40_YDL055C
A.D[VEI]guanyltransferase),
41 synthesizes
HAVDI GDP-mannose
N-Cadherin
from GTPligand
Y
in cell wall biosynthesis; required for normal cell wallcarboxylic
structure
acid metabolism (0.01)
Y
0.007
protein_40_YBR142W
2 MAK5: Essential nucleolar protein, putative DEAD-box
[KGL]K..K[EVT]
41 P.[ST]PKK.KK
of M1 dsRNA virus;
Cdc2involved
like protein
in biogenesis
kinase substrate
of large (60S)
motif
ribosomal subunits
0.008
protein_40_YBR048W
[KAL]K.[AP]FT
ribosome (0.01)
0.005
protein_40_YBL016W
2 FUS3: Mitogen-activated serine/threonine protein kinase
[EGN]FA[SPW]L
involved in mating; phosphoactivated
41
by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation
Y
0.004
protein_40_YBL016W
2 FUS3: Mitogen-activated serine/threonine protein kinaseK..S[RPA]
41 K..[ST]
by Ste7p; substrates
PKA kinase
includesubstrate
Ste12p, Far1p,
motifBni1p, Sst2p; inhibits invasive growth during mating by phosphorylating
response
Tec1p,topromoting
pheromone
its degradation
(1e-06)
0.008
protein_40_YBL003C
D[ENY]E[EAG]
41 required
SEDEE
for chromatinCKII
assembly
kinase
andphosphorylation
chromosome function;
site (peptide
DNA damage-dependent
screen)
phosphorylation by Mec1p facilitates
chromosome
DNA repair; (1e-04)
acetylated by Nat4p
Y
0.008
protein_40_YAL032C
[SEK]D..I[PHT]
0.008
protein_40_YAL032C
K[MPW]..L[EMW]
Y
0.006
oshea_nucleolus
2 oshea_nucleolus
[TEM]D.SK[RQP]
41 KR
CLV_PCSK_PC1ET2_1
nucleolus (1e-09)
0.005
oshea_cytoplasm
2 oshea_cytoplasm
S.[KDT]P
41 [ST]P
LIG_WW_4LIG_WW_4
0.008
oshea_ambiguous
2 oshea_ambiguous
E..N[SQW]
41
bud (1e-05)
Y
0.008
matsuyama_ER
2 matsuyama_ER
Y.[IFW]I
41 [IVL]Y.[PF]
ABL phosphorylation site
nuclear envelope-endoplasmic reticulum network (1e-09)
0.010
genetic_YPL055C
2 LGE1: Protein of unknown function; null mutant formsE[FEH].[EHN]S
41
0.008
genetic_YLR200W
2 YKE2: Subunit of the heterohexameric Gim/prefoldin proteinN.E
41folding
[LIVMFY][DN]G[LIVMF][DN][LIVMF][DN].E
CHITINASE_18
and actin
PATTERN
cell cycle (1e-18)
0.008
genetic_YGL058W
2 RAD6: Ubiquitin-conjugating enzyme (E2), involved in SI[IM]D[IYC]
41
sporulation, telomere silencing, and ubiquitin-mediated N-end
Y
rule protein degradation (with Ubr1p)
Y
0.005
protein_40_YBR160W
[EA]M.RL[EKF]
41
0.005
yeast-649_GO-0003676
2 nucleic acid binding
Q[QKM]Q
40
RRM_1
1.E-08
-3.5
0.009
yeast-235_GO-0000278
2 mitotic cell cycle
S[SPN][SLV]K
40 S[ST]
Pkinase
1.E-03
-1.6
0.009
yeast-1721_GO-0016043
T.[SNK]S
40
HEAT
1.E-03
-1.6
0.008
protein_40_YKL014C
A[RPE][AGE]G
DEAD
-1.4 subunit
0.008
yeast-513_GO-0005515
2 protein binding
E.[NLT]K
40
SH3_1
1.E-02
-1.3
Y
0.008
protein_40_YKL014C
[AEY]A..LD[IQ]
DEAD
-1.2 subunit
nucleolus (1e-05)
0.005
[QPD]AL
40 DALDL
IBN_N
1.E-06
-1.2
0.010
protein_40_YPL093W
[TRM]G..K[TGV]
40
and is required for 60S ribosomal subunit biogenesis; constituent of
Helicase_C
66S pre-ribosomal particles;
1.E-08 member-1
of the ODN
cytoplasm
family of nucleolar
organization
G-proteins
0.008
protein_40_YKR001C
2 VPS1: Dynamin-like GTPase required for vacuolar AT..[THK]S[KPN]
40 SP organization, late
ERK1,
Golgi-retention
ERK2 Kinase
of some
substrate
proteins, regulating
motif
peroxisome
SNF2_Nbiogenesis1.E-02
-0.9
Y
0.005
protein_40_YHR196W
2 UTP9: Nucleolar protein, component of the small subunitK..[KFL]R
40 the
[KR]R
U3 snoRNA that isCLV_PCSK_KEX2_1
S4
1.E-02
-0.9
nucleolus (1e-29)
0.007
yeast-312_GO-0006414
[IV]D.PGH
40 D..G
motif that binds phosphate in GDP andGTP_EFTU_D2
GTP binding proteins1.E-08
-0.8
translation elongation factor activity (1e-08)
0.005
yeast-294_GO-0006366
TT...[NPK]
40
Zn_clus
1.E-03
-0.8
0.008
yeast-215_GO-0005694
2 chromosome
L[LY].[LR]FD
40
SNF2_N
1.E-02
-0.8
chromosome (1e-09)
0.006
protein_40_YHR088W
2 RPF1: Nucleolar protein involved in the assembly of theA..A[EKF]
large ribosomal subunit; constituent
40 A.AA.VP....VP........P
PLU-1
particles;
transcription
containsfactor
a sigma(70)-like
binding motif
motif,in
which
BF-1
IBN_N
is and
thought
PAX9
to bind1.E-02
RNA
-0.8
0.008
yeast-238_GO-0017111
[TDG]I[GKD]V
40
Ras
1.E-05
-0.7
Y
0.009
protein_40_YBR010W
2 HHT1: One of two identical histone H3 proteins (seeAL.[ERQ][LVT]A
40 for chromatin assembly, involved in heterochromatin-mediated telomeric HEAT
-0.7
methylation, and mitotic phosphorylation
0.004
protein_40_YLR293C
[EHQ]LL[ET]V
40 of nuclear
[DE]..LL
organization,Di-Leu
RNA processing
acidic motif
and transport;
for receptor
regulated
endocytosis
by Prp20p,
IBN_N
(recognized
Rna1p, Yrb1p,
by VHS
Yrb2p,
1.E-02
domain
Yrp4p, Yrb30p,
of-0.5
GGACse1p
proteins)
protein
and Kap95p;
importyeast
into Gsp2p
nucleus
homolog
(0.001)
Y
0.005
protein_40_YJR066W
[RKA]P..LK[TR]
40 thatKR
controls growth in CLV_PCSK_PC1ET2_1
response to nutrients by regulating translation, transcription,
GATA ribosome1.E-04
-0.5 transport
nitrogen
and autophagy;
utilization
involved
(1e-06)
in meiosis
Y
0.005
protein_40_YMR093W
[DHM]E[SEK]D
40 E[ST]D
the U3 snoRNA thatAnkyrin
is involved
G in
binding
processing
motifofin
pre-18S
KNCQ2
rRNA
and KNCQ3
WD40
potaqssium channels
1.E-04
-0.3
nucleolus (1e-20)
0.008
yeast-610_GO-0031090
L[LAM]G
40 LLG
Mito_carr
1.E-08
-0.1
envelope (1e-69)
0.008
yeast-1115_GO-0006996
2 organelle organization and biogenesis
Q.S[SGQ]
40 S[ST]
PI3_PI4_kinase
1.E-03
-0.1
0.008
yeast-341_GO-0045449
L..[PNH]S
40
zf-C2H2
1.E-08
0
0.009
protein_40_YJL109C
K..K[RL]
40 KR
is involved in processing of pre-18S Y
rRNA
WD40
1.E-06
0.1
0.007
protein_40_YJL074C
[VEN].TE
40 [ST]E
in mitotic cells; alsoGrequired,
protein-coupled
with Rec8p,
receptor
for cohesion
kinase
and1recombination
substrate
SMC_N
motif
during meiosis;1.E-02
phylogenetically
0.1
conserved
cohesin
SMC chromosomal
complex (1e-04)
Y
0.007
yeast-1433_GO-0006139
2 nucleobase, nucleoside, nucleotide and nucleic acid metabolism
G..K
40 G..G..K
Sulfonate donor binding site in sulfotransferases
Y
Helicase_C
1.E-05
0.2
Y
0.008
protein_40_YCL059C
K..K[RL]
40 assembly
KR of 40S ribosomal
CLV_PCSK_PC1ET2_1
subunit
Y
WD40
1.E-05
0.2
0.007
protein_40_YGL105W
E.[IFD]Lsynthetases (Mes1p
40 and
YE.[IV]
Gus1p), deliveringSH2
tRNAligand
to them,
forstimulating
Fes (Tyr must
catalysis,
be phosphorylated)
and ensuring
Pkinase
the cytoplasm; 0.3
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-13)
Y
0.007
protein_40_YBR009C
2 HHF1: One of two identical histone H4 proteins (see also
R..R[RYQ]
40 forR.[RK]R
chromatin assembly
CLV_PCSK_FUR_1
and chromosome function; contributes to telomeric
Histone
1.E-07
domain involved
0.4 in maintaining
nuclear chromatin
genomic integrity
(1e-08)
0.007
oshea_bud_neck
2 oshea_bud_neck
R..D
40
RhoGAP
1.E-05
0.6
Y
0.008
yeast-413_GO-0005215
L..[TGI]A
40
MFS_1
1.E-14
0.7
Y
0.008
yeast-335_GO-0016772
[KHA]Y..PS[NEK]
groups
40 Y..P
SH2 ligand group 1B-Crk, SH2 binding motif
Pkinase
for ITK, Nck and1.E-02
RasGAP to Doc-R
0.7 (needs
transferase
to be Tyr
activity,
phosphorylated)
transferring phosphorus-containing groups (1e-09)0.006
yeast-513_GO-0005515
2 protein binding
Q[QSE]L
40
HEAT
1.E-03
0.8
Y
0.008
protein_40_YBR159W
V..[FAI]F
40
in the promoter region; mutants exhibit reduced VLCFAYsynthesis, accumulate
MFS_1 high levels
1.E-05
1
transporter
phytosphingosine
activity
and medium-chain
(1e-08)
ceramides
Y
0.007
yeast-980_GO-0051179
2 localization
F..[VAL]F
40 F..LF
Androgen receptor motif that interacts with AF2
MFS_1
1.E-11
1.1
Y
0.008
yeast-235_GO-0009653
2 morphogenesis
D[GNW]..[GNL]KT
40
Ras
1.E-05
1.1
0.005
yeast-235_GO-0000902
D[GNW]..[GNL]KT
40
Ras
1.E-05
1.1
0.005
protein_40_YPL217Cs
2 BMS1: Essential conserved nucleolar GTP-binding protein
K..K[RKI]
required for synthesis of
4040S ribosomal
KR
subunits and
CLV_PCSK_PC1ET2_1
for processing of the 35S pre-rRNA at sites A0, WD40
1.E-03
with Rcl1p, has
1.1
similarity
rRNA
to Tsr1p
processing (1e-36)
0.007
protein_40_YDL126C
2 CDC48: ATPase in ER, nuclear membrane and cytosol
GI..[DG]Q[QP]
with homology to mammalian
40 p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation ubiquitin
of ubiquitinated proteins
1.E-02
from the ER1.1
into the cytosol for degradation by the proteasome
0.005
yeast-255_GO-0042254
K.[LKA]A
40
Y
DEAD
1.E-05
1.2
Y
0.009
yeast-238_GO-0017111
E.[SNF]A
40
Ras
1.E-17
1.2
Y
0.009
yeast-255_GO-0007028
K.[LKA]A
40
Y
DEAD
1.E-05
1.3
Y
0.009
yeast-274_GO-0005840
2 ribosome
A[ARE].GD[AFI]
40 RGD
LIG_RGDLIG_RGD
Ribosomal_60s
1.E-08
1.5
ribosome (1e-08)
0.006
protein_40_YJL081C
A[IK]..DD[EH]
[VA]P[IL]A..E[SD]D
enzyme
Ankryn
complexes
G binding motif in voltage gated sodium
Histone
channels 1.E-04
1.6
protein_40_YDR224C
2 HTB1: One of two nearly identical (see HTB2) histoneIR.[DL]D[EA]
40 R.L
Cyclin A motif
function;
thatRad6p-Bre1p-Lge1p
binds cdk2 complexes
Y mediatedHistone
1.E-04
transcriptional
1.6 activation,
establishment
meiotic DSB formation
and/or maintenance
and H3 methylation
of chromatin architecture
Y (1e-05) 0.005
protein_40_YER012W
2 PRE1: Beta 4 subunit of the 20S proteasome; localizes
[PA][FYR]GV
to the nucleus throughout 40
the cell LVPRG
cycle
Protease Thrombin
Y
Proteasome
1.E-11
1.7
0.007
yeast-238_GO-0017111
I.I[LDV]
40
Y
AAA
1.E-11
2.3
Y
0.009
protein_40_YGL105W
[IGN][HMC]..IK
synthetases (Mes1p
the cytoplasm; 2.6
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-08)
0.006
protein_40_YGR103W
2 NOP7: Nucleolar protein involved in rRNA processingR[EQK][LIE]A
40 MR[DE][IL]
TUBULIN_B_AUTOREG
different pre-ribosomal PATTERN
particles;
Y required forDEAD
exit from G0
1.E-02and the 2.8
initiation of
cytoplasm
cell proliferation
Y
0.008
protein_40_YDL013W
2 SLX5: Subunit of the Slx5-Slx8 substrate-specific ubiquitin
[KM][PIT]EN
40 by prior
[ST]E
attachment of SUMO
G protein-coupled
to the substratereceptor kinase 1 substrate
Pkinase
motif
1.E-07
3.1
Y
0.007
yeast-436_GO-0031323
L.Q[DHE]
40 LSQE
Y
zf-C2H2
1.E-05
3.3
Y
0.009
protein_40_YDL153C
AP[EAN][VL]
40for pre-18S rRNa processing; essential nucleolar protein that, when
Y overproduced,
Pkinase
disrupts silencing
1.E-16
3.4
Y
0.007
protein_40_YDR496C
2 PUF6: Pumilio-homology domain protein that binds[TRQ]G.GK[TIE]
40sequences
[SAG]GGTG[SA]G
in the 3' UTR TUBULIN
and represses
PATTERN
its translation, resulting in proper asymmetric
DEAD localization
1.E-07
of ASH1 mRNA
3.9
0.005
protein_40_YMR229C
2 RRP5: Protein required for the synthesis of both 18S and
D[FGD]G
5.8S rRNA; C-terminal region
40 isD.G.T..K.I
Pyrophosphate
of 18S rRNA binding
and N-terminal
motif,region
activeissite
required
forPkinase
S-Adenosylmethionine
component
(AdoMet)
of small
4.6synthetase
ribosomal
rRNAsubunit
metabolism
(SSU) processosome
(1e-14)
Y
0.007
protein_40_YDL014W
2 NOP1: Nucleolar protein, component of the small subunit
[RSG]R.[AKQ]R
40 is required
R.[RK]R
for processing
CLV_PCSK_FUR_1
of pre-18S rRNA; has similarity to mammalian
Helicase_C
fibrillarin
1.E-03
4.6
nucleolus (1e-10)
0.007
protein_40_YGL120C
2 PRP43: RNA helicase in the DEAH-box family, functionsR..R[TER]
I and polymerase
R.[RK]RII transcript
CLV_PCSK_FUR_1
metabolism, involved in release of the lariat-intron
Helicase_C
1.E-02
5.5
nucleolus (1e-25)
0.007
yeast-256_GO-0016462
2 pyrophosphatase activity
[RLF]G[LID]D
40 RGD
LIG_RGDLIG_RGD
Helicase_C
1.E-11
6.4
0.008
yeast-1939_GO-0003824
[ILMV]K..NI[LFA]
40
Y
Pkinase
1.E-49
6.4
0.008
yeast-1389_GO-0044260
2 cellular macromolecule metabolism
K[LIE].[DEP]FG
40
Pkinase
1.E-45
6.4
0.009
protein_40_YKL014C
[HGA]R..R[TEY]
40 associated
Protease
pre-ribosomal
matriptase
particle;
protease
proposed
site
Yto be involved
Helicase_C
6.6 subunit
nucleolus (1e-11)
0.007
yeast-341_GO-0045449
[ASL]C..C[RGE]
40 C..C
Y
proteins
Zn_clus
1.E-21
17.8
Y
0.009
7
8
9
7
8
10
9
7
8
7
9
8
7
8
10
10
7
9
10
10
10
9
10
7
10
10
7
9
10
9
10
10
10
10
10
10
10
9
10
10
10
8
7
10
9
8
10
9
7
10
8
9
9
10
9
10
10
8
10
10
7
8
10
10
10
10
9
10
10
10
10
10
9
8
10
10
10
10
10
7
10
10
8
10
7
10
8
10
10
8
7
8
10
10
10
10
10
10
10
10
10
10
10
10
8
10
10
10
8
8
10
7
10
10
10
10
10
9
10
10
9
10
10
10
9
10
9
10
10
10
10
10
10
10
yeast-376_GO-0019219
yeast-523_GO-0030529
yeast-462_GO-0019222
yeast-388_GO-0007275
yeast-267_GO-0000003
yeast-235_GO-0009653
yeast-235_GO-0000902
yeast-205_GO-0005856
yeast-1721_GO-0016043
yeast-1062_GO-0016020
protein_40_YPR144C
protein_40_YPL198W
protein_40_YPL153C
protein_40_YPL012W
protein_40_YOR272W
protein_40_YOL133W
protein_40_YNL244C
protein_40_YNL178W
protein_40_YNL118C
protein_40_YML063W
protein_40_YLR180W
protein_40_YLR096W
protein_40_YLR029C
protein_40_YLL034C
protein_40_YLL011W
protein_40_YLL011W
protein_40_YKL203C
protein_40_YKL166C
protein_40_YKL145W
protein_40_YKL101W
protein_40_YJR145C
protein_40_YJR010C-A
protein_40_YJR002W
protein_40_YJR002W
protein_40_YJL164C
protein_40_YJL138C
protein_40_YJL095W
protein_40_YJL092W
protein_40_YIL094C
protein_40_YIL061C
protein_40_YHR135C
protein_40_YHR114W
protein_40_YHR088W
protein_40_YHR088W
protein_40_YHL030W
protein_40_YHL001W
protein_40_YGR245C
protein_40_YGR218W
protein_40_YGL179C
protein_40_YFR034C
protein_40_YEL037C
protein_40_YDR477W
protein_40_YDR450W
protein_40_YDR388W
protein_40_YDR381W
protein_40_YDR324C
protein_40_YDR224C
protein_40_YDL147W
protein_40_YDL083C
protein_40_YDL055C
protein_40_YBR059C
protein_40_YBR009C
protein_40_YBL026W
protein_40_YAR007C
oshea_Total__
oshea_bud
oshea_bud
matsuyama_Cytosol
genetic_YPL055C
genetic_YNL153C
genetic_YLR200W
genetic_YLR200W
genetic_YAL024C
yeast-1433_GO-0006139
protein_40_YNL002C
protein_40_YPR161C
protein_40_YOL077C
protein_40_YHR066W
yeast-341_GO-0045449
protein_40_YGL111W
protein_40_YOR181W
yeast-341_GO-0045449
oshea_bud_neck
yeast-388_GO-0007275
yeast-1115_GO-0006996
protein_40_YLL008W
protein_40_YLR293C
protein_40_YDL213C
yeast-233_GO-0006629
protein_40_YNL186W
matsuyama_ER
protein_40_YNL132W
yeast-256_GO-0016462
yeast-238_GO-0017111
protein_40_YOL069W
matsuyama_Mitochondria
matsuyama_Cytosol
yeast-238_GO-0017111
yeast-240_GO-0006807
yeast-1493_GO-0043234
protein_40_YDR427W
yeast-1974_GO-0005634
protein_40_YOL018C
yeast-661_GO-0050789
yeast-1062_GO-0016020
protein_40_YDR449C
yeast-1721_GO-0016043
protein_40_YDL013W
protein_40_YBR009C
yeast-648_GO-0050791
yeast-335_GO-0016772
protein_40_YLL008W
protein_40_YER036C
protein_40_YLR186W
protein_40_YAR019C
protein_40_YNL298W
yeast-238_GO-0017111
protein_40_YDR324C
genetic_YNL153C
protein_40_YER006W
protein_40_YPL203W
yeast-1974_GO-0005634
protein_40_YKL021C
yeast-1115_GO-0006996
yeast-335_GO-0016772
yeast-565_GO-0006464
yeast-706_GO-0043412
yeast-294_GO-0006366
yeast-256_GO-0016462
yeast-320_GO-0006355
yeast-436_GO-0031323
yeast-376_GO-0019219
yeast-628_GO-0043037
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
8
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
regulation of nucleobase, nucleoside, nucleotide and[ASL]C..C[RGE]
40 C..C
Y
proteins
Zn_clus
1.E-21
18.9
Y
acid metabolism
0.008 (1e-34)
10
[KGR]K.R[GAT]
40
0.008
10
[EA][ENV]DEV
40 DEVD
Protease Caspase 2, 3, 7
0.009
10
I[DPT]N[SPH]
40
0.009
10
reproduction
[STH]PA[SAG]
40 [ST]P
LIG_WW_4LIG_WW_4
Y
Y
0.009
10
morphogenesis
[PSQ]QQ[SIT]
40 S[QT]Q
ATM phosphorylation of this motif
Y on Chk2
0.009
10
[PSQ]QQ[SIT]
40 S[QT]Q
ATM phosphorylation of this motif
Y on Chk2
0.009
10
cytoskeleton
E[LEC][LDM]K
40 EED
Y
0.009
10
Q[KQD]I[LGA]
40
Y
0.008
10
membrane
T.[TGA]F
40
Y
0.008
10
[ENH][ETR].DQ
Y
0.006
10
[NQG][KCY].VVV
Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding
cytosolic
Domain (NDB2)
ribosome (sensu Eukaryota) (0.001)
0.004
7
RAD53: Protein kinase, required for cell-cycle arrest
[VQE]K..K[KSQ]
activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
0.008
10
RRP12: Protein required for export of the ribosomal[KTV]K..K[KRV]
40 components
KR
of the pre-ribosomes;
CLV_PCSK_PC1ET2_1
contains HEAT-repeats
nucleolus (1e-19)
Y
0.008
10
E[ETV][EHR]E
40 ribosomal
EEEEYFELV
subunit
EGFR kinase substrate motif
Y
0.008
10
[VKF]E.Y[IRP]
40(SCF);
[DE].Y
required for Gic2p,SHP1
Far1p,phosphatase
Sic1p and Cln2p
substrate
degradation;
motifmay tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF
Y
0.007
10
SUI1: Translation initiation factor eIF1; component of
K[VEW].[EFG]V
a complex involved in recognition
40 of the initiator codon; modulates translation accuracy at the initiation phase
translation initiation factor activity (1e-04)
0.007
10
R[RAV].A[RKL]
40
(AP) endonuclease activity; essential for viability; has similarity
Y
to E. coli S3 and rat S3 ribosomal proteins
0.008
10
M[ALH].L[TEY]
40
the 5' cap structure from mRNAs prior to their degradation;
Y member of the Nudix hydrolase family
Y
0.006
7
R[VAT].[GIR]G
0.008
10
E..K[EQV]
Y
0.007
10
KIN2: Serine/threonine protein kinase involved in regulation
Y[GAM]..[EYD]D
of exocytosis; localizes
40to theYM
cytoplasmic face ofSH2
the plasma
ligandmembrane;
for Vav1 (group
closely II)
related
(phospho-peptide)
to Kin1p
0.005
10
AR[AYP][GKY]
to Rpl15Bp
[AG]R
and has similarity
Protease
to rat L15
matriptase
ribosomal protein;
protease
binds
site
to 5.8 S rRNA
0.007
9
[TK]AFT[KDC]
subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
0.005
9
RKR[SGL][KD]
40 similarity
KR to the beta subunit
CLV_PCSK_PC1ET2_1
of trimeric G-proteins and the splicing factor Prp4p
0.005
8
VS.L[SYT][DFL]
0.004
9
AS..[STG][SFM]
40 thatS..[ST]
regulates growth inCasein
response
Kinase
to nutrients
I consensus
and TORC2,
phosphorylation
a complex thatsite
regulates
(N-term
cell-cycle
Ser must
dependent
first be
polarization
phosphorylated)
plasma
involved in meiosis
0.008
10
DS.V[VAG][KLI]
40 in response
R.DSPVR
to nutrients 14-3-3
via the Ras-cAMP
binding motif
signaling
on N-terminal
pathway; inhibited
domainbyofregulatory
Nitrate Reductase
subunit Bcy1p
necessary
in the absence
for 14-3-3
of cAMP;
binding
partially
forredundant
inactivation
with Tpk1p
in the and
darkTpk2p
0.005
9
YD.[AWM][LYT]
40
in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the
proteasome
complex
ligase
(sensu
Ubr1p Eukaryota) (1e-05)
0.005
8
HSL1: Nim1p-related protein kinase that regulates the
SV[EDK][EDI]
morphogenesis and septin checkpoints;
40 YRSVDE
associates withBranched
the assembled
chainseptin
alpha-ketoacid
filament; required
dehydrogenase
along with Hsl7p
kinase
for bud
substrate
neck recruitment,
motif
phosphorylation, and degradation of Swe1p
0.008
10
[ADG]E.[EAN]A
0.008
10
SPC1: Subunit of the signal peptidase complex (SPC),
I[GID]..[LYM]LV
which cleaves the signal sequence
40 D..LL
from proteins targeted
Di-Leu
to the
motif
endoplasmic
for receptor
reticulum
endocytosis
(ER), homolog
(recognized
of the SPC12
by VHS
subunit
domain
of mammalian
of GGA signal
proteins)
peptidase complex
0.004
7
MPP10: Component of the SSU processome, which[DGP][TAL]LLT
40 LLTP
interacts with and
WD40
controls
domain
the stability
of Cdc4
of Imp3p
binding
andmotif,
Imp4p,Thr
essential
must be
for viability;
phosphorylated,
similar to human
CPD motif
Mpp10p
0.004
8
MPP10: Component of the SSU processome, which [LE]K..G[LN]T
40
0.005
8
K...A[SKN]
40 in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p
0.007
10
L[DE][EIK]PT
40 that
P[ST]
DNA dependent
to RNA binding
Protein
and unwinding;
kinase substrate
Yforms a dumbbell
motif structure of two compact domains connected
ATPase
by a activity
linker; interacts
(0.01)with eIF4G
0.005
10
PE..[SVH][YH]
kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.006
10
[PIY]S..E
for proper
QPS..E
Phosphorylation
to meiotic recombination
motif in alpha
and transition
3A,
Y alphafrom
6A,Meiosis
alpha I7A
to II;
Integrin
affects tails
genome stability by suppressing
DNA metabolism
unscheduled(0.01)
homologous recombination
Y
0.007
10
I[TDF].E[LTE]
40 forF.E
DNA
biosynthesis
binding motif
of lysine,
in MutS
in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
0.008
10
SNP1: Component of U1 snRNP required for mRNA
L[LAV]..AD[NKS]
interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein
0.004
8
T.[NSR]D
40 T..D
FHA1
in morphogenesis,
binding motif,proper
Thr must
septinbe
assembly,
phosphorylated,
endocytic trafficking;
binding motif
provides
of proteins
an essential
binding
function
to Chk2
overlapping with that of Yck2p
0.007
10
BZZ1: SH3 domain protein implicated in the regulation[ETI][TC]YE
40to recruit
YEactin polymerization
TPK-IIB/P38Syk
machinery through
kinase
its SH3
phosphorylation
domains, colocalizes
site (peptide
with cortical
screen)
actin patches and Las17p, interacts with type I myosins
0.004
8
RPF1: Nucleolar protein involved in the assembly of[DKG]D.[EDN]E
40 D.D
Ribose
particles;
moiety
contains
of UDP
a sigma(70)-like
and manganese
motif,binding
which is site
thought
in glucuronyl
to bind RNAtransferase
0.008
10
RPF1: Nucleolar protein involved in the assembly ofEA..[DS][SHF]D
40
of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
0.005
9
ECM29: Major component of the proteasome; tethersLV.Q[LY][NK]
the proteasome core particle40
to the regulatory particle, and enhances the stability of the proteasome
0.005
9
K[AT]..AE[ICQ]
cytosolic ribosome (sensu Eukaryota) (0.001)
0.005
8
SDA1: Highly conserved nuclear protein required for
[THG][KWT]..KQ
actin cytoskeleton organization
40and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis ribosome biogenesis (1e-04)
Y
0.005
9
[NEG]P..[FPC]A
40 from
P..Pthe nucleus
SH3 general ligand,
0.006
10
TOS3: Protein kinase, related to and functionally redundant
S[AEQ].S[SLG]
with Elm1p and Sak1p40
for theS[ST]
phosphorylation and
MDC1
activation
BRCT
of Snf1p;
domain
functionally
binding orthologous
motif
to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
0.008
10
A[RAE]K[AVF]
40
with Pho2p to the PHO5 promoter; function is regulated
Y by phosphorylation at multiple sites and by phosphatecytosolic
availability part (1e-07)
Y
0.007
10
IV..[GT][GWY]S
40(with Rad4p) during nucleotide excision repair; regulates Rad4pYlevels, subunit of Nuclear Excision Repair Factor 2 (NEF2);
Arp2/3
homolog
protein
of human
complex
HR23A (1e-04)
and HR23B proteins
0.005
7
SNF1: AMP-activated serine/threonine protein kinase found
D.[FLE]N
in a complex containing
40Snf4pSD.E
and members of the
Casein
Sip1p/Sip2p/Gal83p
kinase II substrate
family; required
motif for transcription of glucose-repressed genes, thermotolerance,
response
sporulation,
to external
and peroxisome
stimulusbiogenesis
(0.01)
0.007
10
[AVG]RV[TGR]
to Rps18Bp
[AG]R
and has similarity
Protease
to E. coli
matriptase
S13 and ratprotease
S18 ribosomal
site proteins
eukaryotic 43S preinitiation complex (0.001)
0.006
10
RVS167: Actin-associated protein, subunit of a complex ED[LVP]
40 in regulation
EED of actin cytoskeleton,
Ankyrin B endocytosis,
C-terminal motif
and viability
that binds
following
internal
starvation
Ankyrin
or osmotic
repeats
stress; homolog of mammalian
cellamphiphysin
cortex (1e-07)
Y
0.007
10
YRA1: Nuclear protein that binds to RNA and to Mex67p,R.[ISQ]K
40 mRNA
R.[ST]
from the nucleus;
PKAmember
consensus
of the phosphorylation
REF (RNA and export
sitefactor binding proteins) family; another family member,nuclear
Yra2p, can
lumen
substitute
(1e-05)
for Yra1p function
0.007
10
[EM][ETF].DQ
0.005
9
S[EQ].DK[KRM]
40 SQ
ATM kinase
function;
substrate
Rad6p-Bre1p-Lge1p
motif
mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.004
8
RPN5: Essential, non-ATPase regulatory subunit of [SHF]L.[EIK]AS
40
proteasome complex (sensu Eukaryota) (0.001)
0.004
7
RA.[KRG][VGA]
0.008
10
KI[SPD][IPY]K
guanyltransferase),
0.004
9
AKL1: Ser-Thr protein kinase, member (with Ark1p SNN[PAS][FEQ]
40 involved
NPF in endocytosisEH
and
EFactin
hand
cytoskeleton
domain binding
organization
motif,
Y Class I
endocytosis (1e-05)
0.004
9
HHF1: One of two identical histone H4 proteins (see[RLD]AA[RPE]
40 for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining
cytosolicgenomic
part (1e-05)
integrity
0.007
10
ET..[KEY][LK]R
either KR
Lsm1p or 8p): cytoplasmic
CLV_PCSK_PC1ET2_1
Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
Y
0.004
10
RFA1: Subunit of heterotrimeric Replication Protein A K[EN][VW]Y
(RPA), which is a highly conserved
0.004
7
Q[VD]F[EW]G
40
vacuolar membrane (1e-05)
0.006
8
oshea_Total__
F[FLW]F[LFV]
40 F.F
WASP Homology 1 binding motif
0.017
10
oshea_bud
[VES][PVL]..QQQ
40
bud neck (0.001)
0.005
9
oshea_bud
E[VHY]..K[LG]E
40
Y
0.005
9
matsuyama_Cytosol
[RQG]S..[VGW]S
40 S...S
0.009
10
T[NQD]..[EYL]E
40 YE diploid null mutant
TPK-IIB/P38Syk
displays delayed
kinase
premeiotic
phosphorylation
DNA synthesissite
and(peptide
reduced efficiency
screen) of meiotic nuclear division
0.007
10
GIM3: Subunit of the heterohexameric cochaperoneKE..[QHE]S[IQP]
specifically
KENto cytosolic chaperonin
LIG_APCC_KENbox_2
and transfers target proteins to it
0.006
10
YKE2: Subunit of the heterohexameric Gim/prefoldin protein
K.[PLG]S
40folding
KSGST
eIF4 motif and
phosphorylation
actin
motif
cell cycle (1e-08)
Y
0.007
10
S[DHP]D
40folding
S.D
CAMKII phosphorylation
and actin
site
cell cycle (1e-08)
0.007
10
Q.Q[REK]
40 acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates
mitotic
with
cell
Ras2p-GTP
cycle (1e-06)
0.007
10
I[NRA]K
39 RRT[IV][ATN]KYR
SIGMA54_2 PATTERN
Helicase_C
1.E-05
-1.6
0.008
10
E[EDQ]..[MDK]E
39 of 66S pre-ribosomal particles; plays an essential role in processing of precursors
Brix
to the large
1.E-03
ribosomal subunit
-1.5 RNAs
0.007
10
SGV1: Cyclin (Bur2p)-dependent protein kinase that[LQR][EDK].KK
39 RKK.[ST]
phosphorylates theZIP
carboxy-terminal
domain of Rpo21p,
motifYwhich is the
HMG_box
largest subunit of RNA
1.E-02
polymerase-1.4
II; regulated
nucleic
by Cak1p
acid binding (1e-04)
0.007
10
KR..[VEA][EKD]
39to defects
KR in rRNA processing
CLV_PCSK_PC1ET2_1
and a block in the assembly of large ribosomalBrix
subunits; possesses
1.E-03
a sigma(70)-like
-1.4 RNA-binding
cytoplasm
0.008
10
[KVH]K..K[KRQ]
39 maturation;
KR
functionallyCLV_PCSK_PC1ET2_1
redundant with Ssf2p; member of the Brix family DEAD
1.E-03
-1.4
0.008
10
S[ETN]E[ELR]
39 [ST]E
bZIP_1
motif
1.E-06
-1.2
0.008
10
G[RTY]..R[AIW]
39biogenesis
DEAD
1.E-04
-1.1
Y
0.005
8
LAS17: Actin assembly factor, activates the Arp2/3 Q[QAH]..[QFG]A
SH3_1 of the human
1.E-06
Wiskott-Aldrich
-1syndrome
endocytosis
protein (WASP)
(1e-07)
0.006
10
E.E[NVM]
39 Y.E.E
Src phosphorylation site
Zn_clus
1.E-05
-0.8
0.008
10
oshea_bud_neck
L[NQS]..[ANS]T
39
SH3_1
1.E-02
-0.8
bud (1e-30)
0.008
10
development
[ASD]N.[SQR]L
39 N.[TS]
RasGEF_N
1.E-02
-0.6
0.008
10
S.[IQH]E
39
Helicase_C
1.E-03
-0.5
0.008
10
K.[EVY]E
including
YEsynthesis of 60S ribosomal
TPK-IIB/P38Syk
subunits; kinase
constituent
phosphorylation
site
Pkinase
(peptide
particles screen)1.E-07
-0.5
0.007
10
[NMT]E[TSC]SK
39 of nuclear organization, RNA processing and transport; regulated by Prp20p,
IBN_N
1.E-02
Yrp4p, Yrb30p,
-0.4 Cse1p
nuclear
and Kap95p;
pore (1e-05)
yeast Gsp2p homolog
0.004
8
EL[AM]K[HTI]
39RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may HEAT
be a fungal-specific1.E-02
gene as no homologs
-0.4 have been yet identified in higher eukaryotes
Y
0.004
9
lipid metabolism
L[LFM]G
39
PAP2
1.E-03
-0.2
0.008
10
[EDR]E.L[YW]
may regulate
ENLYFQ[GS]
silencing by acting
Protease
on Sir4p;
TEVinvolved
- stringent
in posttranscriptionally regulating
Pkinase
Gap1p and 1.E-03
-0.1
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-04)
0.005
10
matsuyama_ER
Y.L[GFW]
39
MFS_1
1.E-03
-0.1
Y
0.010
10
KRE33: Essential protein of unknown function; heterozygous
K..K[RLA]
mutant shows haploinsufficiency
39 KR in K1 killer toxinCLV_PCSK_PC1ET2_1
resistance
Y
WD40
1.E-05
0
0.007
10
V.E[LAY]
39
Helicase_C
1.E-14
0.1
Y
0.008
10
V..[DAP]E
39
Helicase_C
1.E-11
0.1
0.008
10
LK[DLI][SEL] Ndc80 complex
39 LLKIL
AP-2 binding motif
involved
in in
CXCR2
chromosome
receptor
segregation,
SMC_N
spindle checkpoint
1.E-03
0.1
microtubule
clustering
Y
0.008
9
D.[VPN]L
39 D.D.[TV]
Motif in PRS1 and PRS-2 required for phosphatase
HEAT activity and
1.E-04
salt stress 0.3
response
GTPase regulator activity (0.01)
0.010
10
matsuyama_Cytosol
QR[ARC]
39 RRR
ER retention signal in NR1 glutamate receptor
RhoGEF
1.E-02
0.3
cell septum (0.01)
Y
0.010
10
V.E[LAY]
39
Helicase_C
1.E-11
0.4
Y
0.008
10
G..[IAV]A
39
GATase
1.E-02
0.6
Y
0.008
10
protein complex
[DIL]E..[DLS]E
39 [ST]E
HEAT
motif
1.E-02
0.6
0.008
10
RPN9: Non-ATPase regulatory subunit of the 26S proteasome,
[NRQ]N.[SEI]LL
has similarity to putative
39 proteasomal
N.[TS] subunitsN-linked
in other species;
glycosylation
null mutant
siteis temperature sensitive
PCI
and exhibits cell1.E-02
cycle and proteasome
0.9 assembly
proteasome
defectsregulatory particle (sensu Eukaryota) (0.01)
0.004
8
nucleus
S..[PKG]S
39 S...S
WD40
1.E-10
1.1
0.008
10
TLG2: Syntaxin-like t-SNARE that forms a complex with
[GP]Q[EDN]R
Tlg1p and Vti1p and mediates
39 fusion of endosome-derived vesicles with the late Golgi; binds
Y Vps45p, which
Rasprevents Tlg2p1.E-05
degradation and
1.1also facilitates
GTPase
t-SNARE
activity
complex
(1e-05)
formation
0.004
7
H..[ITN]I
39
Pkinase
1.E-03
1.3
0.008
10
membrane
L..V[AFP]
39 VP
Interleukin converting enzyme protease
MFS_1
1.E-05
1.3
Y
0.008
10
[FT][SRM].DG
39 the
S.D
U3 snoRNA that isCAMKII
involvedphosphorylation
in processing of pre-18S
site rRNA
WD40
1.E-06
1.3
0.006
10
L..[LAS]N
39
Y
IBN_N
1.E-04
1.5
0.008
10
[LVI]N[HR]P
39 by prior
Y[ILV]N[VP]
attachment of SUMO
SH2 ligand
to the substrate
for SEM5 (C.elegans Grb2) (TyrPkinase
must be phosphorylated)
1.E-04
1.5
0.005
8
HHF1: One of two identical histone H4 proteins (see
LE..[GMA][NKE]A
39 for chromatin assembly and chromosome function; contributes to telomeric
Histone
1.E-03
domain involved
1.5 in maintaining genomic integrity
0.005
10
H..[INT]I
39
Pkinase
1.E-04
2
0.008
10
GS..[VKT][YDV]
groups
39 S..[ST]
Pkinase
must first be phosphorylated)
2
10
LLDK[NMT]
Pkinase
particles
1.E-03
2.2
Y
0.004
8
[TE][RIS]ELA
ribosome
[ST]E
biogenesis, has similarity
G protein-coupled
to Gcn20p; shuttles
receptor
from
kinase
nucleus
Y 1 substrate
to cytoplasm,
DEAD
motif
physically interacts
1.E-03
with Tif6p,2.3
Lsg1p RNA helicase activity (0.01)
0.004
7
EMG1: Protein required for the maturation of the 18S
[DGT]G.[IVN]K
production; associated with spindle/microtubules; nuclear localization dependsWD40
on physical interaction
1.E-07
with Nop14p;
2.4may bind
rRNA
snoRNAs
processing (1e-19)
Y
0.007
10
PE..[LTV][LSI]
1.E-18
2.4
Y
0.008
10
CLA4: Cdc42p activated signal transducing kinase ofV[KQ]..D[FY]G
the PAK (p21-activated kinase)
39 family, involved in septin ring assembly and cytokinesis; directly phosphorylates
Pkinase
septins Cdc3p1.E-03
and Cdc10p; other
2.7 yeastprotein
PAK family
kinase
members
activity
are Ste20p
(0.01)
and Skm1p
0.005
9
A..[AGR]L
ABC_tran
1.E-13
2.8
0.008
10
D[KG][TRH]VK
Y
WD40
1.E-04
2.9
0.005
7
[THD]R.[KIL]K
specifically
R..Kto cytosolic chaperonin
SH3 binding
and transfers
motif for
target
GADS
proteins
SH3torecognizing
it
Pkinase
1.E-04
2.9
Y
0.007
10
GK.[AS]A[FMK]
required for export
DEAD
1.E-03
3.1
ribosome assembly (0.001)
0.005
8
[AIC][DAH]FG
39 in response
LFG to nutrients Protease
via the Ras-cAMP
Papainsignaling
substrate,
pathway;
a prototype
inhibitedcysteine
byPkinase
regulatory
proteinase
subunit Bcy1p
1.E-07
in the absence
3.2 of cAMP;
protein
partially
kinase
redundant
activity
with(1e-06)
Tpk1p and Tpk3p
0.005
9
nucleus
R[DKE]I
39 MR[DE][IL]
TUBULIN_B_AUTOREG PATTERN
Zn_clus
1.E-05
3.3
0.008
10
MAK11: Protein involved in an early, nucleolar step of[PR][THS].IQ
39 essential
GIQVD for cell growth
dynein
and light
replication
chainofLC8
killerinteracting
M1 dsRNA virus;
motifcontains
-alternative
DEAD
1.E-06
repeats
3.7
Y
0.005
8
D..I[RKQ]
39
WD40
1.E-14
5.1
0.008
10
M[EDH]Y
39 [DE]YY
Tyr phosphorylated in activation Y
loop of JakPkinase
1.E-32
5.2
Y
(1e-49)0.008
10
[ILMV]K..N[ILR]L
39
Pkinase
1.E-42
6.3
0.008
9
[ILMV]K..N[ILF]L
39
Pkinase
1.E-49
6.5
0.008
10
R[KYF]R
39 HHH[RK]SPR[RK]R
Cdc2 kinase substrate motif
Zn_clus
1.E-02
8.4
transcription from RNA polymerase II promoter (1e-11) Y
0.008
10
[GW]R..R[AGK]
39 R.[RK]R
CLV_PCSK_FUR_1
Y
Helicase_C
1.E-22
9.2
0.009
10
[ASY]C..C[RDE]
39 C..C
Y
proteins
Zn_clus
1.E-21
17.2
0.009
10
[ALS]C..C[REG]
39 C..C
Y
proteins
Zn_clus
1.E-20
17.7
0.008
10
regulation of nucleobase, nucleoside, nucleotide andCR.[RKT][KHY]
39 R.[ST]
Zn_clus
1.E-22
18.2
0.009 (1e-24)
10
translation
E..F
39
0.008
10
ribonucleoprotein complex
development
yeast-468_GO-0051276
yeast-468_GO-0051276
yeast-343_GO-0005198
yeast-295_GO-0016192
yeast-244_GO-0000279
yeast-235_GO-0009653
yeast-235_GO-0000902
yeast-1721_GO-0016043
protein_40_YPL146C
protein_40_YPL093W
protein_40_YOR310C
protein_40_YOR290C
protein_40_YOL133W
protein_40_YOL133W
protein_40_YOL120C
protein_40_YOL069W
protein_40_YOL041C
protein_40_YOL018C
protein_40_YOL001W
protein_40_YNL154C
protein_40_YNL132W
protein_40_YNL118C
protein_40_YNL002C
protein_40_YMR242C
protein_40_YMR236W
protein_40_YMR236W
protein_40_YMR116C
protein_40_YMR012W
protein_40_YLR180W
protein_40_YLR180W
protein_40_YLR009W
protein_40_YLL039C
protein_40_YLL008W
protein_40_YKL014C
protein_40_YJR145C
protein_40_YJR022W
protein_40_YJL138C
protein_40_YJL106W
protein_40_YJL010C
protein_40_YIL095W
protein_40_YHR135C
protein_40_YHR088W
protein_40_YGR086C
protein_40_YGL173C
protein_40_YGL137W
protein_40_YGL105W
protein_40_YGL031C
protein_40_YFR034C
protein_40_YFL039C
protein_40_YFL037W
protein_40_YER177W
protein_40_YER148W
protein_40_YER110C
protein_40_YDR471W
protein_40_YDR388W
protein_40_YDR172W
protein_40_YDR099W
protein_40_YDR099W
protein_40_YDR087C
protein_40_YDL213C
protein_40_YDL212W
protein_40_YDL055C
protein_40_YDL055C
protein_40_YDL043C
protein_40_YDL030W
protein_40_YDL013W
protein_40_YDL013W
protein_40_YBR245C
protein_40_YBR059C
protein_40_YBR048W
protein_40_YBR036C
protein_40_YBR031W
protein_40_YAL032C
protein_40_YAL032C
oshea_vacuole
oshea_mitochondrion
oshea_ambiguous
matsuyama_Cytosol
genetic_YNL153C
genetic_YLR200W
genetic_YGL058W
genetic_YGL058W
protein_40_YBL003C
protein_40_YGR128C
oshea_bud_neck
yeast-388_GO-0007275
yeast-1547_GO-0043283
yeast-649_GO-0003676
yeast-649_GO-0003676
protein_40_YNL002C
yeast-322_GO-0005654
yeast-320_GO-0006355
yeast-320_GO-0006355
yeast-504_GO-0006350
yeast-513_GO-0005515
yeast-436_GO-0031323
protein_40_YGR085C
protein_40_YAL032C
yeast-256_GO-0016462
yeast-752_GO-0016787
matsuyama_periphery
protein_40_YOL069W
yeast-630_GO-0051244
yeast-215_GO-0005694
protein_40_YBR009C
yeast-921_GO-0006810
yeast-661_GO-0050789
yeast-752_GO-0016787
protein_40_YNL298W
yeast-939_GO-0051234
protein_40_YMR047C
yeast-312_GO-0006414
protein_40_YNL031C
protein_40_YLR197W
yeast-939_GO-0051234
yeast-939_GO-0051234
yeast-235_GO-0000278
protein_40_YOL133W
yeast-238_GO-0017111
oshea_microtubule
protein_40_YAR019C
protein_40_YGL245W
protein_40_YOL139C
protein_40_YPR016C
protein_40_YGL207W
protein_40_YDR324C
yeast-460_GO-0006351
yeast-335_GO-0016772
yeast-335_GO-0016772
yeast-1340_GO-0044267
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
[DNC]R..S[TFK]T
39 R..S
Calmodulin-dependent protein kinase II substrate motif
Y
0.008
10
ND.EL[SP]
39 D.E
Sec24pSec24pSec24p
0.006
8
L[SFI]L
39
0.008
10
DD[LNF][LFY]
39
Y
0.008
10
M phase
N..[VDH]D
39
Y
M phase (1e-13)
0.008
10
morphogenesis
[PVT]T[TPD]T
39 TPTP
Motif for hydroxylation of Pro residues, which can further be modified with arabinogalactan
0.008
10
[PVT]T[TPD]T
39 TPTP
Motif for hydroxylation of Pro residues, which can further be modified with arabinogalactan
0.008
10
A[TEM]N
39
0.008
10
NOP53: Nucleolar protein; involved in biogenesis of K[EH][AGY]LE
39 interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
0.004
7
[DGV]D.[EK]E
39 D.E
and is required for Sec24pSec24pSec24p
60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN
cytoplasm
family of nucleolar
organization
G-proteins
Y
0.008
10
[GMS]K..VQ[LN]
0.005
7
SNF2: Catalytic subunit of the SWI/SNF chromatin remodeling
[AD][KVE]VEE
complex involved in39
transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
0.004
7
[YI][KR].PE
39(SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF
Y
0.005
9
VQ..I[PQ][LQK]
Y
0.004
8
[ITF]A.G[KTI]S
39 and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation
Y
0.004
8
[IQG]K.L[KEQ] Ndc80 complex
39
(Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome
Y segregation, spindle checkpoint activity and kinetochore
microtubule
clustering
0.008
10
NOP12: Nucleolar protein, required for pre-25S rRNA
[GAM][SPK]RP
processing; contains an RNA
39recognition
[KR]R
motif (RRM) and
CLV_PCSK_KEX2_1
has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe
Y
0.006
9
TLG2: Syntaxin-like t-SNARE that forms a complex LNK[IFT][KVQ]
with Tlg1p and Vti1p and mediates
39 fusion
G[SA]LNK
of endosome-derived
GDP-mannose
vesicles with
binding
the latemotif
Golgi;in
binds
transporter
Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation
0.004
9
PE[EHG]
39 EED
Ankyrin
Pho4p
B C-terminal
and Swi5p;motif
deletion
thatofbinds
PHO80
internal
leads toAnkyrin
aminoglycoside
repeatssupersensitivity; truncated form of PHO80 affects vacuole inheritance
0.007
10
NA[TDS]
39
functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p
Y
0.007
10
R..A[RKN]
39
in K1 killer toxin resistance
0.007
10
V[DAP].[VA]N
39 VP
the 5' cap structureInterleukin
from mRNAsconverting
prior to theirenzyme
degradation;
protease
0.006
9
DD.[EKP][EYT]
39 D.E
of 66S pre-ribosomalSec24pSec24pSec24p
particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
0.008
10
RA[AGP][RSK]
0.008
10
[IMV][LI]GKL
39 II transcription initiation and in chromatin modification, similar to histone H3
transcription from RNA polymerase II promoter (0.01) Y
0.005
7
I[LVS]..L[QYE]N
39 II transcription
L...I...[IL]initiation and
Corepressor
in chromatin
nuclear
modification,
box motif
similar
binds
to histone
to nuclear
H3
receptors
0.004
8
ASC1: G-protein beta subunit and guanine nucleotide
A[SEC].[KVR]I
39 ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the
RNA
absence
metabolism
of amino acid
(0.01)
starvation
0.007
9
CLU1: eIF3 component of unknown function; deletion
[EMH]Q.[VCE]D
39 organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
0.005
10
SAM1: S-adenosylmethionine synthetase, catalyzesK[EGM].V[SGH]
Y
0.007
9
SAM1: S-adenosylmethionine synthetase, catalyzes R[IFG][LQM]A
0.007
10
RLP24: Essential protein with similarity to Rpl24Ap and[KDM]R...E
Rpl24Bp, associated with 39
pre-60SRE..E
ribosomal subunitsIron
and required
binding for
motif
ribosomal
in ferritin
large
L-chain
subunitand
biogenesis
yeast Iron transport protein
Y
0.007
9
UBI4: Ubiquitin, becomes conjugated to proteins, marking
[DPK]D[ED]LQ
39 LPDEL
via the ubiquitin-26SMotif
proteasome
in CBPsystem;
for interaction
essential with
for thePPARg-LBD
cellular stress(secondary
response; encoded
site) as a polyubiquitin precursor
actincomprised
cortical patch
of 5 head-to-tail
(0.01) repeats
0.005
9
NT..[AL][EWA]T
including
T..[IL]
FHA2 binding
subunits;
motif,
constituent
Thr must
of 66S
be phosphorylated
0.004
8
S[NR].[KVE]KD
0.004
9
A[FM]..K[IQ]
20S pre-rRNA processing; identical to Rps4Bp and has similarityYto rat S4 ribosomal protein
0.005
10
[DV][ALS]..KIS
0.004
9
G[RQV]F[GCR]
Y
0.005
9
IME2: Serine/threonine protein kinase involved in activation
[KIV]D..AL[ANG]
of meiosis, associates39
with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
0.004
10
NOP9: Essential component of pre-40S ribosomes [SKG]K..K[KLS]
39 of 35S
P.[ST]PKK.KK
pre-rRNA and hence
Cdc2formation
like protein
of 18S
kinase
rRNA;substrate
binds RNAmotif
in vitro and contains multiple pumilio-like repeats
Y
0.007
10
PRK1: Protein serine/threonine kinase; regulates the
S[RNT]..[SWE]NA
39 actinS[ST]
MDC1
the phosphorylation
BRCT domainofbinding
the Pan1p-Sla1p-End3p
motif
protein complex
0.004
7
YCK1: Palmitoylated, plasma membrane-bound caseinN..[RNG]R
39 [KR]R
CLV_PCSK_KEX2_1
in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function
nucleic
overlapping
acidwith
binding
that of(0.001)
Yck2p
0.007
10
RPF1: Nucleolar protein involved in the assembly of
EN..[KPL][KTQ]K
39
of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
nucleolus (1e-05)
0.004
7
EA[KQF]L[LVN]
39 associated
IEAD with endocytosis;
Protease
nullCaspase
mutants show
10 activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
0.005
7
[RM]EV[KQM]
39 (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomalRNA
RNA maturation,
metabolism
and telomere
(1e-04)maintenance
0.005
8
SEC27: Essential beta'-coat protein of the COPI coatomer,
[IHS]K[EYV]VI
involved in ER-to-Golgi39
and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian
COPI vesicle
beta'-COP
coat (0.001)
0.004
8
[EQL]DGD[VE]
synthetases (Mes1p
39 and
D.D
Gus1p), deliveringRibose
tRNA tomoiety
them, stimulating
of UDP and
catalysis,
manganese
Yand ensuring
binding
theirsite
localization
in glucuronyl
to the cytoplasm;
transferase
also binds quadruplex nucleic acids
Y
0.004
7
RPL24A: Ribosomal protein L30 of the large (60S) ribosomal
K[ATQ]..AE[IQ]
subunit, nearly identical
39 to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation
cytosolicrate
ribosome (sensu Eukaryota) (0.001)
0.005
10
Q[TQ]K[LDS]T
39 [KR].TQT
with Pho2p to the
LIG_Dynein_DLC8_1
PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability
0.004
7
K[SD]Q[LPR]D
cytoskeletal
SQ functions
0.004
7
[DPY]R..[DCR]E
Y
0.005
10
R[KGT].S[FPN]
39bindsKKR..S
proteins and DNA,Phosphorylation
involved in regulation
siteoffor
many
MLCK
processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
Y
0.007
10
SPT15: TATA-binding protein, general transcription N[IGE].[QDE]SL
39 to form the preinitiation complex at promoters, essential for viability
RSC complex (0.01)
0.004
8
KAP123: Karyopherin beta, mediates nuclear import[PQG][SDK]TG
assembly
STG
into ribosomes and
EH(3)
import
EFofhand
histones
domain
H3 and
binding
H4; localizes
motif to
of the
EPS15,
nuclearClass
pore, II
nucleus, and cytoplasm; exhibitssnRNP
protein import
with RAI1
Y
0.007
10
S.[ILMV]S
0.007
10
RVS167: Actin-associated protein, subunit of a complex E..[LIQ]K
39 in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian
cellamphiphysin
cortex (1e-05)
Y
0.007
10
SUP35: Translation termination factor eRF3; altered protein
LA[LIS]N[NF]
conformation creates 39
the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype
0.005
7
BMH2: 14-3-3 protein, minor isoform; controls proteome
A[TQD]..[SEW]S
0.008
9
D[NT].N[EGW]
0.007
10
RRP1: Essential evolutionarily conserved nucleolar protein
[SEI]E.E[EAM]
39of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal
nucleolus
particles
(1e-18)
0.008
10
LI..[LMP]D[PAL]
39RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.005
8
SHR3: Endoplasmic reticulum packaging chaperone,F[IQC]..G[LIF]
required for incorporation of 39
amino acid permeases into COPII coated vesicles for transport to the cell surface
amine transporter activity (0.001)
0.006
10
[GDL]VE[TFA]
guanyltransferase),
39 synthesizes
VEHD GDP-mannose
Protease
from GTP
Caspase
6-stringent
Y
0.008
10
SN.[TEY][KSD]F
guanyltransferase),
39 synthesizes
N.[TS] GDP-mannose
N-linked
from glycosylation
GTP and mannose-1-phosphate
site
0.004
7
PRP11: Subunit of the SF3a splicing factor complex,
I[PMF]..DL[SEA]
39 WDL
Binding motif for AP-2 and clathrin heavy chain ear
RNA binding (1e-04)
Y
0.004
8
PRP9: Subunit of the SF3a splicing factor complex, required
TG..[DF]L[KF]
for spliceosome assembly;
39 acts
TGY
after the formation
ERK6/SAPK3
of the U1 snRNP-pre-mRNA
activation sites
complex
forYHOG/p38 activation
0.005
7
K[KQT]SK[IML]
39 by prior
RKK.[ST]
attachment of SUMO
ZIP kinase
to the substrate
phosphorylation motif
Y
0.004
7
Y[NWI]NN[NL]
39 by prior
Y.N attachment of SUMO
LIG_SH2_GRB2
to the substrate
0.005
7
ISW1: Member of the imitation-switch (ISWI) class ofE[IR].[KFQ]EI
ATP-dependent chromatin remodeling
39 EEEIYEEIE
complexes; ATPase
cFPS/FES
that formskinase
a complex
phosphorylation
with Ioc2p and Ioc4p
site to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation
0.005
10
AKL1: Ser-Thr protein kinase, member (with Ark1p and
S[SEN]TP[AE]
Prk1p) of the Ark kinase family;
39 involved
[ST]Pin endocytosisLIG_WW_4LIG_WW_4
and actin cytoskeleton organization
0.005
7
R[ARG][AQH]R
39 and
[AG]R
Protease
coli S17 and
matriptase
rat S11 ribosomal
proteaseproteins
site
0.007
10
CSG2: Endoplasmic reticulum membrane protein, required
YY.[YCV][VL]
39 [DE]YY[RK] and
PTP1B
for growth
phosphatase
at high calcium
substrate
concentrations
motif
0.004
8
ID..[RDQ][NI]S
39 nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins
0.004
8
AN..[LDP][KSF]
0.008
10
N..I[IRY]
39 interacts
IY with splicing factors
cFGRPrp22p
and Csk
and kinase
Prp46p;phosphorylation
orthologous to human
site transcriptional
(peptide screen)
coactivator SKIP and can activate
spliceosome
transcription of
(1e-08)
a reporter gene
Y
0.007
10
oshea_vacuole
F.[LYV]V
39 YF.[FPLY]
vacuole (1e-13)
0.008
10
[SYE]L[QGI]SS
39 S[ST]
0.006
9
S[NDI]..S[LPF]
39 SP
0.008
10
oshea_mitochondrion
[KEQ]K[KRY]K
39 KKKKKK[ST] TGF beta receptor kinase substrate
Y motif
0.008
10
L[SNY][PYA]V
39
Y
0.008
10
oshea_ambiguous
[NSK]T..L
39 T..[IL]
FHA2 binding motif, Thr must be phosphorylated
0.008
10
D..[LEP]E
39
spindle (1e-13)
0.010
10
matsuyama_Cytosol
A..[FAD]R
39 [AG]R
Y
0.010
9
NL[RKQ]
cell cycle (1e-08)
0.007
10
DI[TSI]
microtubule-based process (1e-08)
0.007
10
D.K[KIL] repair (with Rad18p),
39 [LI][IVCAP]D.K[LIFY]E[FI]G
sporulation, telomere
SAICAR_SYNTHETASE_2
silencing, and ubiquitin-mediated
PATTERN
N-end rule protein degradation (with Ubr1p)
Y
0.007
10
LR[ELP] repair (with Rad18p),
39 RPL
VEGFR
silencing,
andand
neuropilin
ubiquitin-mediated
binding peptide
N-end rule protein degradation (with Ubr1p)
0.007
10
K[APV].[RSL]K
38 required
KAPRK[QH][LI]
for chromatinHISTONE_H3_1
PATTERN
function; DNA damage-dependent
Histone phosphorylation
1.E-02 by Mec1p
-2.3 facilitates
DNADNA
metabolism
repair; acetylated
(1e-08)
by Nat4p
0.007
10
E[ELD].E[KED]
38 with
SEDEE
CKII kinase
processome
phosphorylation
containing thesite
U3 snoRNA
(peptidethat
screen)
WD40
1.E-05
of pre-18S
-2.2
Y
0.007
10
oshea_bud_neck
N.[QDS]Q
38 [ST]Q
Pkinase
1.E-04
-1.7
Y
0.007
10
development
P.[SLM]P
38 P.[ST]P
Erk p44 MAP kinase phosphorylation site Pkinase
1.E-02
-1.6
0.008
10
R..F[DNEQ]
38
PI3_PI4_kinase
1.E-03
-1.6
0.008
10
nucleic acid binding
N[NHA]..[NVH]N
38
zf-C2H2
1.E-05
-1.4
0.008
10
E[NES]E[DSF]
38 [ST]E
RRM_1
motif
1.E-04
-1.2
Y
0.008
10
H[RFG]..R[TGK]
38 of 66S pre-ribosomal particles; plays an essential role in processing
Y
of DEAD
1.E-04
ribosomal subunit
-1.2 RNAs
0.005
8
nucleoplasm
KR.[KRQ]
38 KR
CLV_PCSK_PC1ET2_1
PHD
1.E-03
-1
nucleoplasm (1e-17)
Y
0.008
10
[HYP]TG[END]K
38 LP.TG
C-terminal sorting signal which targets surface
zf-C2H2
proteins of Staphylococcus
1.E-09
aureus
-1
to
regulation
the cell wall
of peptidoglycan;
Sortase cleaves between
(1e-10)Thr and Gly and C-termini
0.007
is used for 10
E.E[VEK]
38 Y.E.E
Zn_clus
1.E-07
-0.9
Y
0.008
10
transcription
T.[ATY]P
38 [ST]P
LIG_WW_4LIG_WW_4
Zn_clus
1.E-04
-0.8
0.008
10
protein binding
SS[EDA][LKW]
38 S[ST]
HEAT
1.E-02
-0.6
0.008
10
[DNI]AT[NIL]
38
Zn_clus
1.E-02
-0.5
0.008
10
[KLF]G.K[VS]T
to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation
Ribosomal_L7Ae
of proteins and RNA of1.E-02
the 60S subunit;
-0.5
has similarity
cytosolic
to E. coli
ribosome
L5 and rat
(sensu
L11
Eukaryota) (1e-07)
0.004
9
D[SFC].[DIH]D
38 interacts with splicing factors Prp22p and Prp46p; orthologous to human
Helicase_C
transcriptional coactivator
1.E-02
SKIP and-0.5
can activate
spliceosome
transcription of
(0.001)
a reporter gene
0.007
10
L[IWG]D
38 WDL
Binding motif for AP-2 and clathrin heavy chain
ABC_tran
ear
1.E-12
-0.2
0.008
10
hydrolase activity
L..D[AVY]
38
Y
AAA
1.E-04
-0.1
hydrolase activity, acting on ester bonds (1e-54)
Y
0.008
10
matsuyama_periphery
K[LPT]S
38 RK.SF
PKCepsilon kinase phosphorylation site (peptide
PH screen) 1.E-06
-0.1
0.009
10
[DKQ]L..K[LVI] Ndc80 complex
38
SMC_N
spindle checkpoint
1.E-03
0.2
microtubule
clustering
0.008
10
K..[KSA]P
38 K..[ST]
Zn_clus
1.E-03
0.4
Y
0.008
10
chromosome
D..Q[GQI]
38
SMC_N
1.E-06
0.4
chromosome (1e-89)
0.008
10
HHF1: One of two identical histone H4 proteins (see alsoR[EKT]I
38 forLRT
chromatin assembly
LKB1
and chromosome
Kinase substrate
function;
motif
contributes to telomeric
Histone
1.E-02
domain involved
0.4 in maintaining
DNA metabolism
genomic integrity
(1e-07)
Y
0.007
10
transport
F..[VAL]F
38 F..LF
MFS_1
1.E-10
0.6
Y
0.008
10
K..[KSA]P
38 K..[ST]
Zn_clus
1.E-02
0.6
Y
0.008
10
hydrolase activity
P..[LRG]I
38
Y
UCH
1.E-05
1.1
Y
0.008
10
CLA4: Cdc42p activated signal transducing kinase ofN[VGQ]I[DI]T
the PAK (p21-activated kinase)
38 family,
[IL][ILP]TP[RK]
involved in septinCDC4
ring assembly
WD40 and
domain
cytokinesis;
bindingdirectly
motif
Y phosphorylates
Septin
septins Cdc3p1.E-05
and Cdc10p; other
1.1 yeastphospholipid
PAK family members
binding
are Ste20p
(1e-05)
and Skm1p
0.004
8
S..[TFI]G
38 S..[ST]
Y
MFS_1
1.3
Y
0.008
10
NUP116: Subunit of the nuclear pore complex (NPC) that
L..[KEP]D
of the pore; contains a repetitive GLFG motif that interacts with mRNA exportIBN_N
with karyopherin
1.3
transport (1e-33)
Y
0.007
10
[EPD]SV[GC]
38 R..[ST]V
CamKII consensus phosphorylation siteRibosomal_60s
more stringent
1.E-05
1.5
Y
0.005
8
HHT2: One of two identical histone H3 proteins (see[RFH]H[LPV]Q
38 forHPQ
chromatin assembly,
Biotin
involved
binding
motif in streptavidin
Y telomericHistone
1.5
methylation,
establishment
and mitotic
and/or
phosphorylation
8
K.L[ADM]
38 snoRNP
LLKIL
complexes thatAP-2
direct binding
2'-O-methylation
motif in of
CXCR2
pre-rRNA
receptor
during
Y
its maturation;
WD40overexpression
1.E-04
causes spindle
1.8 orientation
nucleolus
defects(1e-34)
0.007
10
F.G[ILG]
38 FRGGT
Phosphoinositide binding motif in ATG18 and
Mito_carr
ATG21
1.E-11
1.9
Y
0.008
10
[LFS]D..K[TVS]R
38
Mito_carr
1.E-27
2
0.008
9
mitotic cell cycle
K[LSF][QRT]R
38 [KR]R
CLV_PCSK_KEX2_1
Kinesin
1.E-02
2
Y
0.008
10
L..[ILR]D
conjugating enzyme
2 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(1e-13)
of SCF
Y
0.007
10
A..[GEQ]R
38 [AG]R
Y
Ras
1.E-12
2.1
Y
0.008
10
oshea_microtubule
SSRSH
38 S[ST]
Kinesin
1.E-09
2.1
microtubule motor activity (1e-08)
0.005
8
CDC15: Protein kinase of the Mitotic Exit Network thatPE.[INY][LTI]
38 bodies at late anaphase; promotes mitotic exit by directly switching
Y
on thePkinase
1.E-19
2.6
Y
0.007
10
GUS1: Glutamyl-tRNA synthetase (GluRS), forms a [HWN]P.[ISH]V
Pkinase
of both tRNA1.E-04
synthetases and
2.8
ensuresprotein
their correct
kinase
localization
activity
to the
(1e-06)
cytoplasm
0.006
9
CDC33: Cytoplasmic mRNA cap binding protein; the
EN.[LEN]L[DTN]
3.2 orprotein
Tif4632p)kinase activity (0.001)
0.004
10
TIF6: Constituent of 66S pre-ribosomal particles, has PN..KS[SLK]
similarity to human translation
38initiation
KSP...K
GSK-3,
be involved
ERK1,inERK2,
the biogenesis
CDK5 substrate
andYor stability
motif
MMR_HSR1
of 60S ribosomal subunits
1.E-04
3.3
0.004
9
SPT16: Subunit of the heterodimeric FACT complex (Spt16p-Pob3p),
RD.[KRV] facilitates RNA
Pkinase
1.E-10
nucleosome
3.5structure
0.007
10
[DAW]G.I[RKE]
Y
WD40
1.E-04
3.7
Y
0.007
10
K..R
38 R...K..R
Motif in Ebola virus that eliminates IFN-beta
zf-C2H2
production
1.E-07
3.8
transcription, DNA-dependent (10)
0.008
10
M.YC
38
Pkinase
1.E-13
3.8
Y
(1e-14)0.007
9
[GHA]V.[LTI]Y
groups
38 IY
cFGR and Csk kinase phosphorylation sitePkinase
(peptide screen) 1.E-13
4.2
Y
(1e-35)0.009
10
K[LIA].[DGS]FG
38
Pkinase
1.E-43
6.2
0.008
9
yeast-1464_GO-0019538
2 protein metabolism
K[ILY].D[FLT]G
38
Pkinase
1.E-46
6.7
0.008
10
yeast-589_GO-0050896
NS.[LMY][NEG]
38
0.008
10
yeast-523_GO-0030529
2 ribonucleoprotein complex
I..[ILMV]L
38 [LIV]..[LM]L.AA.[FY][LI]
0.008
10
yeast-513_GO-0005515
2 protein binding
G[TC].DV[SLY]
38
0.005
9
yeast-470_GO-0006259
2 DNA metabolism
KS[TGQ][TIR]
38 S[ST]
Y
0.008
10
yeast-410_GO-0007049
2 cell cycle
L[IER].[EMH]D
38
cell cycle (1e-58)
0.008
10
yeast-410_GO-0007049
2 cell cycle
T[LSF].K[MAP]
38
cell cycle (1e-54)
0.008
10
yeast-388_GO-0007275
2 development
L[SNP]..K[NTC]
38
0.008
10
yeast-320_GO-0006355
DD.[IQY]E[DGR]
38 DD.Y
Shb PTB domain binding motif
0.008
10
yeast-284_GO-0005740
2 mitochondrial envelope
E.[DSH]S
38 [LIVMA].EG[DN]SA.[STAG]
TOPOISOMERASE_II PATTERN
0.008
10
yeast-284_GO-0005740
2 mitochondrial envelope
KR[KHV]
38 KR
CLV_PCSK_PC1ET2_1
0.008
10
yeast-256_GO-0016021
2 integral to membrane
[AGP]S..[ILF]IL
38 S..F
LIG_BRCT_BRCA1_1
0.007
9
yeast-255_GO-0042254
[LSE]TR[NTQ]I
38
0.005
8
yeast-255_GO-0007028
[LSE]TR[NTQ]I
38
0.005
8
yeast-248_GO-0043285
2 biopolymer catabolism
TLN[SM][IHP]
38
biopolymer catabolism (1e-07)
0.005
7
yeast-244_GO-0000279
2 M phase
P.[IQN]R
38 P..R..KP
SH3 binding motif for GRB2 C-term
M phase (1e-90)
0.008
10
yeast-235_GO-0009653
2 morphogenesis
T[KAS]..[NQK]N
38
Y
0.008
10
yeast-235_GO-0000902
T[KAS]..[NQK]N
38
Y
0.008
10
yeast-215_GO-0007010
2 cytoskeleton organization and biogenesis
[ILG]Q[EAI]E
38
Y
0.008
10
yeast-207_GO-0006974
2 response to DNA damage stimulus
L[SEC]T[QIR]
38 IRRLSTRRR Nek 2 kinase substrate motif
0.008
10
yeast-1547_GO-0043283
IY..[DQG][IVF]
38 IY
cFGR and Csk kinase phosphorylation site (peptide screen)
0.008
10
protein_40_YPR120C
2 CLB5: B-type cyclin involved in DNA replication during
[VK]H..[LNK]K
S phase; activates Cdc28p 38
to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
Y
0.006
10
protein_40_YPR080W
2 TEF1: Translational elongation factor EF-1 alpha; also
Q[RWQ][GFP]G
encoded by TEF2; functions38
in the RGG
binding reaction of aminoacyl-tRNA
Alternative integrin
(AA-tRNA)
binding
to ribosomes
site in FMDV virus
0.005
10
protein_40_YPL209C
2 IPL1: Aurora kinase involved in regulating kinetochore-microtubule
PK..[KQG][ECW]
attachments; helps
38 maintain condensed chromosomes during anaphase and early telophase; associates with Sli15p, which promotes Ipl1p association with mitotic spindle
0.006
10
protein_40_YPL141C
2 FRK1: Putative protein kinase; similar to Kin4p; greenDIR[SPD][LQ]
38 protein localizes to the cytoplasm; YPL141C is not an essential gene
0.004
7
protein_40_YPL093W
2 NOG1: Putative GTPase that associates with free 60S ribosomal
A.[GVR]K
subunits in the nucleolus
38 KAPRK[QH][LI]
and is required for HISTONE_H3_1
PATTERN
biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN
cytoplasm
family of nucleolar
organization
G-proteins
0.007
10
protein_40_YOR294W
2 RRS1: Essential protein that binds ribosomal protein[ENT]R..A[FRM]
L11 and is required for nuclear
38export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's
cytoplasm
disease
organization
model mice and biogenesis (1e-07)
Y
0.006
10
protein_40_YOR133W
D[KPT]R[EV]
38 [KR]R
CLV_PCSK_KEX2_1
contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
0.005
9
protein_40_YOL133W
NF[VLW][SRH]
38(SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation;
Y may tether Cdc34p (a ubiquitin conjugating enzyme or E2)
macromolecule
and Cdc53p (a cullin)
catabolism
subunits of(1e-04)
SCF
Y
0.007
10
protein_40_YOL086C
2 ADH1: Alcohol dehydrogenase, fermentative isozyme
KLN[NM][GKS]
active as homo- or heterotetramers;
38
required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
Y
0.005
7
protein_40_YOL004W
2 SIN3: Component of the Sin3p-Rpd3p histone deacetylase
N[NKA].[NDL]S
complex, involved in transcriptional
38 NK.Drepression andMotif
activation
for specificity
of diverse processes,
of guanineincluding
in purine
mating-type
binding proteins
switching and meiosis; involved in the maintenance
histone deacetylase
of chromosomal
complex
integrity (1e-08)
Y
0.008
10
protein_40_YNR054C
2 ESF2: Essential nucleolar protein involved in pre-18S
DV..[RIP][GDK]
nucleolus (1e-14)
0.007
9
protein_40_YNL298W
2 CLA4: Cdc42p activated signal transducing kinase [LD]A.NK[GMK]
38 family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
0.004
9
protein_40_YNL289W
2 PCL1: Pho85 cyclin of the Pcl1,2-like subfamily, involved
D..S[VDG]
in entry into the mitotic cell
38cycleDDDD..S
and regulation of morphogenesis,
Casein kinaselocalizes
1 phosphorylation
to sites of polarized
motif cell growth
0.007
10
protein_40_YNL118C
2 DCP2: Catalytic subunit of the Dcp1p-Dcp2p decapping
D[LHQ].N[FAY]
38
Y
0.006
8
protein_40_YMR194W
2 RPL36A: N-terminally acetylated protein componentA[RAG].[KRV]A
38
nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal
Y
Y
0.008
10
protein_40_YMR139W
2 RIM11: Protein kinase required for signal transduction[TAI]NT[SNV]
38
the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta
0.007
10
protein_40_YMR116C
2 ASC1: G-protein beta subunit and guanine nucleotide
[IKD]S..SD[EC]
38 ortholog
S..S of RACK1 thatCasien
inhibits kinase
translation;
I phosphorylation
core component of
site,
the 1st
small
Ser
(40S)
must
ribosomal
be phosphorylated
subunit; represses Gcn4p in the absence of amino acid starvation
0.004
9
protein_40_YMR001C
2 CDC5: Polo-like kinase with similarity to Xenopus Plx1 YQ.T[LCQ]
at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate
0.004
9
protein_40_YML063W
2 RPS1B: Ribosomal protein 10 (rp10) of the small (40S)
R[RAE].A[RLV]
Y
0.007
10
protein_40_YLR448W
RA..[VKM][KAF]
subunit, has similarity to Rpl6Ap
38
and to rat L6 ribosomal protein; binds to 5.8S rRNA
Y
Y
0.007
10
protein_40_YLR429W
2 CRN1: Coronin, cortical actin cytoskeletal component
IE.[ESR][AYR]E
38 IEGR
complex to regulate
Protease
its activity;
Protease
plays a role
Factor
in regulation
Xa
of actin patch assembly
0.004
7
protein_40_YLR180W
2 SAM1: S-adenosylmethionine synthetase, catalyzesA[IGR].[VWP]L
Y
0.007
10
protein_40_YLR029C
RA.[RAP][AFK]
to Rpl15Bp and has similarity to rat L15 ribosomal protein; bindsY
to 5.8 S rRNA
0.007
10
protein_40_YLR002C
2 NOC3: Protein that forms a nuclear complex with Noc2p
EE.E[EAG][EKW]
38precursors
RE..Eto mediate their
Iron
intranuclear
binding motif
transport;
in ferritin
also binds
L-chain
to chromatin
and yeast
to promote
Iron transport
the association
proteinof DNA replication nucleolus
(1e-09) initiation
Y
0.006
10
protein_40_YKL021C
2 MAK11: Protein involved in an early, nucleolar step of 60S
R[VMR]..IV
ribosomal subunit biogenesis;
38 essential
RR.SI for cell growth
PKAand
kinase
replication
phosphorylation
of killer M1 dsRNA
siteY(peptide
virus; contains
screen)
four beta-transducin repeats
nucleolus (1e-06)
0.004
9
protein_40_YJR002W
2 MPP10: Component of the SSU processome, whichR[HEQ]..F[LVD]
38 RQ.SFD
interacts with and
CAM
controls
Kinase
the II
stability
kinase
of phosphorylation
Imp3p and Imp4p, site
essential
(peptide
for viability;
screen)
similar to human Mpp10p
0.006
10
protein_40_YJL164C
2 TPK1: cAMP-dependent protein kinase catalytic subunit;
G[KFG].[KPQ]Q
Y
0.007
10
protein_40_YJL130C
2 URA2: Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate
V[EPA].Y[IH] transcarbamylase
38 Y[LI]
(ATCase), catalyzes
SH2
theligand
first two
forenzymatic
PLCgamma1
steps in
N-term.)group
the de novo biosynthesis
3(phospho-peptide)
of pyrimidines; both activities are subject to feedback inhibition by UTP
0.004
9
protein_40_YJL109C
LL.[KAE][LDT]S
38 LLG
the U3 snoRNA thatBeta2-Integrin
binding of
motif
pre-18S Y
rRNA
0.005
10
protein_40_YIL094C
[AV]N..[KVW]T
0.006
9
protein_40_YIL094C
[SCE][VCM].QD
0.004
8
protein_40_YHR196W
2 UTP9: Nucleolar protein, component of the small subunitV..[TIL]K
nucleolus (1e-31)
0.007
10
protein_40_YHR088W
2 RPF1: Nucleolar protein involved in the assembly ofKK[SDA][KVR]
38 KKSRGDYMTMQIG
Insulin
particles;
receptor
contains
kinase
a sigma(70)-like
substrate motif
motif, which is thought to bind RNA
0.008
10
protein_40_YHR079C
2 IRE1: Serine-threonine kinase and endoribonuclease; transmembrane
D..N[DPG] protein that38
mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.007
10
protein_40_YHR010W
A..[KAP]K
to Rpl27Bp and has similarity to rat L27 ribosomal protein
0.007
10
protein_40_YHL030W
2 ECM29: Major component of the proteasome; tethers
LA.[GL][GRL]E
the proteasome core particle38
to the regulatory particle, and enhances the stability of the proteasome
0.004
8
protein_40_YGR218W
FG..[NGQ]
38 from
G..G..K
the nucleus
Sulfonate donor binding site in sulfotransferases
Y
0.007
10
protein_40_YGR218W
S..[SVW]G
38 from
S..[ST]
the nucleus
Y
site (N-term Ser must first be phosphorylated)
0.007
10
protein_40_YGR060W
2 ERG25: C-4 methyl sterol oxidase, catalyzes the firstIS[GTW][FPI]I
of three steps required to remove
38 two
S[ST]
C-4 methyl groupsMDC1
from anBRCT
intermediate
domain
in binding
ergosterolmotif
biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
0.004
7
protein_40_YGL105W
[FM]SSVS
synthetases (Mes1p
38 and
S[ST]
Gus1p), deliveringMDC1
tRNA toBRCT
them, domain
stimulating
binding
catalysis,
motif
and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
0.005
10
protein_40_YGL076C
[EL]SD[DQ]D
Rpl7Bp
DDDK[ACDEFGHIKLMNQRSTVWY]
to E. coli L30
Enterokinase
and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding
ribosome
Domain (NDB2)
assembly (0.01)
0.004
7
protein_40_YGL076C
[GK]K[TA]LA
Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding
nucleolus
Domain (NDB2)
(0.01)
0.004
7
protein_40_YFR052W
2 RPN12: Subunit of the 19S regulatory particle of the 26S
TNR[PF]D
proteasome lid; synthetically
38 lethal
RGD
with RPT1, whichLIG_RGDLIG_RGD
is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
Y
0.004
7
protein_40_YFR034C
2 PHO4: Basic helix-loop-helix (bHLH) transcription factorK..[ARK]A
38 K[KR].[KR]
with Pho2p to the
Nuclear
PHO5localization
promoter; function
motif is regulated by phosphorylation at multiple sites and by phosphatecytosolic
availability part (1e-19)
0.007
9
G[YWR]..[VQ]GK
Y
0.005
8
protein_40_YER177W
KV[ED][DFS]I
0.004
7
protein_40_YER148W
2 SPT15: TATA-binding protein, general transcription[SNL]A.N[TAG]P
38 to
[ST]P
LIG_WW_4LIG_WW_4
complex at promoters, essential for viability
0.004
8
protein_40_YER125W
2 RSP5: Ubiquitin-protein ligase involved in ubiquitin-mediated
[YFG][VGT]DDT
functions
DD.Y
Shbsorting,
PTB domain
heat shock
binding
response
motifand ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain
0.004
8
protein_40_YDR388W
2 RVS167: Actin-associated protein, subunit of a complex A[TAP]N
38 in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian
protein
amphiphysin
amino acid phosphorylation (0.01)
Y
0.007
10
protein_40_YDR145W
I[ESG].[PS]QL
38 SQ
ATMand
kinase
in chromatin
substrate
modification,
motif similar to histone H2A
transcription from RNA polymerase II promoter (0.01) Y
0.004
7
protein_40_YDL213C
K.[LEH]A
38RNA[VILMAFP]K.E
MOD_SUMOMOD_SUMO
nucleolus
been yet identified
Y
0.007
10
protein_40_YDL140C
K[EPG]..SL[IFN]
38 of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.004
10
protein_40_YDL055C
[LMR]SK[DIS]L
guanyltransferase),
Y
in cell wall biosynthesis; required for normal cell wallligase
structure
activity (0.01)
0.005
9
protein_40_YDL055C
[SWH]F.[DAS]FL
guanyltransferase),
0.004
7
protein_40_YDL055C
GG[GDY]
guanyltransferase),
38 synthesizes
RGG GDP-mannose
Alternative
from GTP
integrin
binding site in FMDV
in cell
virus
wall biosynthesis; required for normal cell wall structure
Y
0.007
10
protein_40_YDL055C
R..[EVY]E
guanyltransferase),
38 synthesizes
YE
GDP-mannose
TPK-IIB/P38Syk
from GTP and kinase
mannose-1-phosphate
phosphorylation
in cell
site
wall
(peptide
biosynthesis;
screen)
required for normal cell wallproteasome
structure
regulatory particle, base subcomplex (sensuYEukaryota) (1e-04)
0.007
10
protein_40_YDL047W
2 SIT4: Type 2A-related serine-threonine phosphatase
D[PRW]..L[RFD]
that functions in the G1/S transition
38 of
R..L
the mitotic cycle; cytoplasmic
LIG_APCC_Dbox_1
and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
0.007
10
protein_40_YBR181C
2 RPS6B: Protein component of the small (40S) ribosomalS.L[STP]
0.007
10
protein_40_YBL027W
S.[LSA]S
to Rpl19Ap
S..Sand has similarity
Casien
to rat L19
kinase
ribosomal
I phosphorylation
protein; rpl19asite,
and rpl19b
1st Ser
single
must
null
bemutations
phosphorylated
result in slow growth, while the double null mutation is lethal
0.007
10
protein_40_YAL032C
[RSM]I...L
38 interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate
nuclear
transcription
mRNA
of asplicing,
reporter gene
Y
0.007
10
protein_40_YAL032C
ED.[ERY][ERI]
38 interacts
YEDP
Fyn SH2
Prp22p
domain
and Prp46p;
binding
orthologous
motif
nuclear
transcription
mRNA
of asplicing,
reporter gene
0.007
10
matsuyama_Nucleus
2 matsuyama_Nucleus
KR[KRM]
38 KR
CLV_PCSK_PC1ET2_1
0.009
10
matsuyama_Nucleus
2 matsuyama_Nucleus
LG[LHA]
38 LLG
0.009
10
SN.[RTQ]
38 N.[TS]
Y
0.009
10
matsuyama_Cytosol
2 matsuyama_Cytosol
[RPC]RL[NR]
38 [KR]R
CLV_PCSK_KEX2_1
purine nucleotide binding (0.01)
0.009
10
genetic_YLR262C
2 YPT6: GTPase, Ras-like GTP binding protein involved
S[QDK].L[KED]
38 for
SQfusion of endosome-derived
ATM kinase
vesicles
substrate
with the
motif
late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity
regulation
to the human
of metabolism
GTPase, Rab6
(1e-08)
Y
0.007
10
genetic_YLR200W
2 YKE2: Subunit of the heterohexameric Gim/prefoldin protein complex
KI
involved in the
38folding
LLKIL
AP-2 binding
andmotif
actin in CXCR2 receptor
cell cycle (1e-19)
0.007
10
protein_40_YBR160W
SK[LDP]N[NQE]
37
0.007
10
protein_40_YER012W
VE[YWN][AHM]
the cell cycle
Y
Proteasome
1.E-09
-4.1
Y
0.006
8
protein_40_YJR059W
2 PTK2: Putative serine/threonine protein kinase involved ST[SAP]
37across
HSTSDD
plasma membrane;
Branched
enhanceschain
spermine
alpha-ketoacid
uptake
dehydrogenase
Pkinase
kinase substrate
1.E-02
motif
-2.6
0.007
10
matsuyama_nucleolus
2 matsuyama_nucleolus
[HG]R..R[TH]A
37 R.[RK]R
CLV_PCSK_FUR_1
Y
DEAD
1.E-10
-1.6
0.006
9
yeast-220_GO-0044255
2 cellular lipid metabolism
V.[ILW]L
37 P.V.L
Shadow-Chromo domain bindingYmotifPI3_PI4_kinase
1.E-02
-1.5
0.008
10
yeast-256_GO-0016462
VV..[EPC]
37
Y
Helicase_C
1.E-06
-1.3
0.008
10
protein_40_YAR019C
2 CDC15: Protein kinase of the Mitotic Exit Network that[AR]PK[PQ]P
37 bodies
K[ST]P.K
at late anaphase;GSK-3,
promotes
ERK1,
mitoticERK2,
exit by CDK5
directly substrate
switching on
motif
thePkinase
1.E-03
-1.3
0.005
7
yeast-1166_GO-0005488
2 binding
R..[QKN]K
37 L..RR..KK
ERK docking motif in RSK stringent
Y
HEAT
1.E-02
-1.1
0.008
10
yeast-294_GO-0006366
[SNY]S.S[PKQ]
37 SPSP
Motif for hydroxylation of Proline residues, zf-C2H2
which can further 1.E-04
be modified with
-1 arabinogalactan
0.008
10
protein_40_YOL133W
L[SVC]..E[PFY]
37(SCF);
[ST]..E
required for Gic2p,Casien
Far1p, Sic1p
kinase
and
II consensus
Cln2p degradation;
phosphorylation
may tether Cdc34p
F-box
site (a ubiquitin1.E-06
conjugating enzyme
-0.7 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(0.001)
of SCF
Y
0.007
10
yeast-648_GO-0050791
2 regulation of physiological process
[RSV]P..[LKE]K
37 [ST]P
LIG_WW_4LIG_WW_4
Y
GATA
1.E-02
-0.6
0.008
10
yeast-521_GO-0051649
2 establishment of cellular localization
N[ENK]..E[DAM]
37
IBN_N
1.E-03
-0.6
0.008
10
yeast-324_GO-0030528
[IQT]P.N[SPM]
37 [ST]P
LIG_WW_4LIG_WW_4
Y
Zn_clus
1.E-07
-0.6
0.008
10
protein_40_YOR294W
2 RRS1: Essential protein that binds ribosomal proteinS[IW]..Q[AKM]
37export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse
Helicase_C
homolog shows altered
1.E-02
expression
-0.6
in Huntington's
cytoplasm
disease
organization
model mice and biogenesis (0.01)
0.004
7
protein_40_YMR047C
SA.[GQV][TPM]
with karyopherin
-0.5
Kap95p;nuclear
homologous
pore
to (1e-13)
Nup100p
Y
0.007
10
protein_40_YFR052W
2 RPN12: Subunit of the 19S regulatory particle of the S[VY]..[TY]LL
37 lethal
[DE]..LL
with RPT1, whichDi-Leu
is an ATPase
acidiccomponent
motif for receptor
of the 19Sendocytosis
regulatory particle;
HEAT
(recognized
physically
byinteracts
VHS
1.E-03
domain
with Nob1p
of-0.5
GGA
and Rpn3p
proteins)
0.004
7
yeast-1115_GO-0006996
S..[SGI]N
37 S..[ST]
Casein Kinase I consensus phosphorylationWD40
must first be -0.1
phosphorylated)
0.008
10
yeast-410_GO-0007049
2 cell cycle
[LRD]FE[KTR]
37
SMC_N
1.E-02
0.2
cell cycle (1e-61)
0.008
10
yeast-222_GO-0009308
2 amine metabolism
E.A[KSG]
37
PALP
1.E-03
0.4
Y
0.008
10
yeast-631_GO-0050794
2 regulation of cellular process
K..[KSA]P
37 K..[ST]
Zn_clus
1.E-03
0.5
Y
0.008
10
protein_40_YHR010W
[APK]R..[AKV]K
to Rpl27Bp
[KR]R
and has similarity
CLV_PCSK_KEX2_1
to rat L27 ribosomal protein
Y
MMR_HSR1
1.E-02
0.5
nucleolus (1e-08)
0.007
10
yeast-1216_GO-0009058
2 biosynthesis
AG[AGF][RAC]
37
Ribosomal_60s
1.E-04
0.9
0.008
10
protein_40_YLR340W
2 RPP0: Conserved ribosomal protein P0 similar to rat[AE]A..[EMF]KE
Ribosomal_60s
1.E-08
0.9
Y
0.004
8
yeast-304_GO-0019752
2 carboxylic acid metabolism
G[NVE]P
37 G[FL]PGER..G LIG_IBS_1LIG_IBS_1
Zn_clus
1.E-02
1.1
0.008
10
yeast-215_GO-0005694
2 chromosome
AG[NS]A[AWT]
37
Y
Histone
1.E-03
1.1
chromosome (1e-07)
0.005
10
yeast-921_GO-0006810
2 transport
S..[TFI]G
37 S..[ST]
Y
MFS_1
1.2
Y
0.008
10
yeast-304_GO-0006082
2 organic acid metabolism
G[NVE]P
Zn_clus
1.E-02
1.2
0.008
10
protein_40_YBR159W
2 IFA38: Microsomal beta-keto-reductase; contains oleate A..[TLS]F
37
MFS_1 high levels
1.E-02
1.2
transporter
phytosphingosine
activity
and medium-chain
(1e-07)
ceramides
0.007
9
yeast-295_GO-0016192
[DVH]T..[QKF]E
37
Y
Ras
1.E-11
1.4
0.008
10
yeast-610_GO-0031090
L[DQW]..[KSM]TR
37
Mito_carr
1.E-18
1.5
mitochondrial inner membrane (1e-11)
0.008
10
genetic_YLR200W
2 YKE2: Subunit of the heterohexameric Gim/prefoldin[WRQ]YR[AV]P
37folding
VP
Interleukin and
converting
actin
enzyme protease Pkinase
1.E-03
1.5
cyclin-dependent protein kinase activity (1e-04)
0.004
10
yeast-238_GO-0017111
E..S[AVG]
Helicase_C
1.E-12
1.6
Y
0.008
10
yeast-565_GO-0006464
HP[NPF][IV]
37 HPQ
Y
UQ_con
1.E-16
1.7
0.008
10
yeast-1721_GO-0016043
A[AES]S
37 RPVSSAASVY 14-3-3 domain binding motif
PI3_PI4_kinase
1.E-04
1.7
0.008
10
protein_40_YLR197W
2 SIK1: Essential evolutionarily-conserved nucleolar protein
D[QKM].[VTR]K
WD40overexpression
1.E-02
causes spindle
1.7 orientation
rRNAdefects
processing (1e-14)
0.007
10
protein_40_YKL014C
K[TEQ][LAV]A
DEAD
1.8 subunit
nucleolus (1e-14)
0.007
10
yeast-376_GO-0019219
2 regulation of nucleobase, nucleoside, nucleotide andDE[ELD][DKR]
37 YDE[PDV]
SH2 ligand for Nck1 and Nck2 (Tyr must bezf-C2H2
phosphorylated) 1.E-02
1.9
0.008 (1e-10)
10
yeast-921_GO-0006810
2 transport
D[VLA].[KRI]TR
37
Mito_carr
1.E-23
2.1
Y
0.008
10
yeast-1134_GO-0044249
N.[DSG]D
37 N.[TS]
SRP1_TIP1
1.E-05
2.6
0.008
10
protein_40_YDR449C
DG.[IVY][KRL]
WD40
1.E-09
2.7
0.007
10
protein_40_YPL203W
[KSH]PE[NPM]
37 in response
[ST]P to nutrients LIG_WW_4LIG_WW_4
via the Ras-cAMP signaling pathway; inhibited byPkinase
1.E-07
in the absence
2.9 of cAMP;
phosphotransferase
partially redundant with
activity,
Tpk1p alcohol
and Tpk3pgroup as acceptor (1e-08)
0.006
10
yeast-1115_GO-0006996
S.D[ARS]
37 S.D
WD40
1.E-15
3.1
0.008
10
yeast-255_GO-0007028
[PTF]TRE[LKY]
37 RE..E
DEAD
1.E-06
3.2
Y
0.006
10
yeast-255_GO-0042254
[PTF]TRE[LKY]
37 RE..E
DEAD
1.E-06
3.3
Y
0.006
10
protein_40_YNL186W
DF..[ATN][KRM]
Y
regulating
Pkinase
Gap1p and 1.E-14
3.6
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-16)
Y
0.006
10
protein_40_YNL186W
IG[ERK][GHF]
Pkinase
Gap1p and 1.E-12
3.8
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-11)
Y
0.006
9
protein_40_YNL186W
2 UBP10: Ubiquitin-specific protease that deubiquitinates ubiquitin-protein
A[PQ]E
moieties; 37
may regulate
A[EA]EEY[FV]F[LFMIV]F
silencing by acting
FGFRonkinase
Sir4p; involved
substrate
motif Y
regulating
Pkinase
Gap1p and 1.E-17
4
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-17)
Y
0.007
yeast-565_GO-0006464
W[SQV][LFE]G
37
Y
Pkinase
1.E-19
4.3
0.008
yeast-1939_GO-0003824
KP.N[ILV][LMK]
37
Pkinase
1.E-59
6.5
0.008
yeast-601_GO-0005829
2 cytosol
[RPG]AA[RKG]
37
cytosol (1e-47)
0.008
yeast-470_GO-0006259
2 DNA metabolism
[TLD]S[EQG]E
37 [PLIM].[LIDE]SQATM kinase substrate motif
0.008
yeast-470_GO-0006259
2 DNA metabolism
T[TPG]..K[KDR]
37 KR
CLV_PCSK_PC1ET2_1
Y
0.008
yeast-410_GO-0007049
2 cell cycle
ET..[KSN][INR]
37 T..[SA]
cell cycle (1e-76)
0.008
yeast-388_GO-0007275
2 development
[TRQ]S.TT[EWC]
37
Y
0.007
yeast-343_GO-0005198
2 structural molecule activity
[GPQ]G.[FM]GN
37
0.005
yeast-301_GO-0044451
2 nucleoplasm part
[LVA]ENN[DMG]
37 KEN
LIG_APCC_KENbox_2
0.007
yeast-301_GO-0044451
2 nucleoplasm part
D..D[DGI]
37
Y
0.008
yeast-262_GO-0031224
2 intrinsic to membrane
A[SFR]..I[IL]L
37
0.006
yeast-244_GO-0000279
2 M phase
NS[FRD][KMH]
37
M phase (1e-46)
0.008
yeast-238_GO-0017111
[HDE]V.[HTC]GK
37
Y
Y
0.005
yeast-238_GO-0017111
I[SVL].E[ELI]G
37
0.006
yeast-235_GO-0009653
2 morphogenesis
TG.[TPM][TPH]
37 TGY
ERK6/SAPK3 activation sites for HOG/p38 activation
0.008
yeast-235_GO-0000902
TG.[TPM][TPH]
37 TGY
ERK6/SAPK3 activation sites for HOG/p38 activation
0.008
yeast-223_GO-0003735
2 structural constituent of ribosome
E..G[VNF]
37
0.008
yeast-220_GO-0044255
L.[LVR]T
37 PLARTLSVAGLP
Calmodulin-dependent protein kinase
Y
IV substrate motif
0.008
yeast-205_GO-0005856
2 cytoskeleton
L[QEN]E
37
0.008
yeast-205_GO-0005856
2 cytoskeleton
TL[DNM]D[LQ]
37 LFDLM
Y
0.005
yeast-1493_GO-0043234
2 protein complex
F[LSW]F
37 F.FP
LIG_MAPK_2LIG_MAPK_2
0.008
yeast-1433_GO-0006139
2 nucleobase, nucleoside, nucleotide and nucleic acidS[DFK]..[SYN]D
metabolism
37
0.008
protein_40_YPR144C
2 NOC4: Nucleolar protein, forms a complex with Nop14p
[SL]T[LIT]EP
and nuclear
IEPD
Proteasesubunits
Granzyme B
processing of 20S pre-rRNA (0.001)
0.004
protein_40_YPR110C
2 RPC40: RNA polymerase subunit, common to RNA polymerase
D..[TRL]I
I and III
37
RNA polymerase complex (1e-09)
0.007
protein_40_YPL240C
2 HSP82: Hsp90 chaperone required for pheromone signaling
A[LKE].D[EDM]
37of Hsf1p;
AEVD
docks with Tom70p
Protease
for mitochondrial
Caspase 10
preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
0.007
protein_40_YPL240C
2 HSP82: Hsp90 chaperone required for pheromone signaling
Q..V[EPN]
37of Hsf1p;
VP docks with Tom70p
Interleukin
for mitochondrial
converting
preprotein
enzymedelivery;
protease
promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
0.007
protein_40_YPL240C
2 HSP82: Hsp90 chaperone required for pheromone TL.[DNEQ][LVA]
37of Hsf1p;
PLTLP
docks with Tom70p
RAF1
forkinase
mitochondrial
substrate
preprotein
motif delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
0.006
protein_40_YPL153C
2 RAD53: Protein kinase, required for cell-cycle arrest AN[LIA][EQM]
Y
Y
0.007
protein_40_YPL153C
2 RAD53: Protein kinase, required for cell-cycle arrestQ[QKS].L[LPM]
Y
0.007
protein_40_YPL043W
2 NOP4: Nucleolar protein, essential for processing EE..V[EGD][EMK]
and maturation of 27S pre-rRNA37
and large
EED
ribosomal subunit
Ankyrin
biogenesis;
B C-terminal
constituentmotif
of 66S
that
pre-ribosomal
binds
Y internal
particles;
Ankyrin
contains
repeats
four RNA recognition motifs (RRMs)
Y
0.004
protein_40_YPL043W
2 NOP4: Nucleolar protein, essential for processing NE..[SDM][DKE]S
and maturation of 27S pre-rRNA37
and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.004
protein_40_YPL012W
2 RRP12: Protein required for export of the ribosomal subunits;
E.E[EK]
associates with the RNA
37 components
Y.E.E of the pre-ribosomes;
Src phosphorylation
contains HEAT-repeats
site
nucleolus (1e-34)
Y
0.007
protein_40_YOR310C
2 NOP58: Protein involved in pre-rRNA processing, 18S rRNA
E..[EC]D
synthesis, and snoRNA
37synthesis;
RE..Ecomponent of Iron
the small
binding
subunit
motif
processome
in ferritin complex,
L-chain and
whichyeast
is required
Iron transport
for processing
protein
of pre-18S rRNA
nucleolus (1e-21)
0.007
protein_40_YOR151C
2 RPB2: RNA polymerase II second largest subunit B150,
[SHL]TGRK
part of central core; similar
37to bacterial
[AG]R
beta subunit Protease matriptase protease site
0.004
protein_40_YOR133W
2 EFT1: Elongation factor 2 (EF-2), also encoded by T[RQG]..V[EGA]
37
during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically
carboxylic
ADP-ribosylated
acid by
metabolism
diphtheria toxin
(0.01)
Y
0.007
protein_40_YOR117W
[LKA][FIY]ESL
37
in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription
0.004
protein_40_YOL120C
SV.[EPR]V
37 and
YRSVDE
has similarity to rat
Branched
L18 ribosomal
chain
protein;
alpha-ketoacid
intron of RPL18A
dehydrogenase
Y pre-mRNA forms
kinase
stem-loop
substrate
structures
motif that are a target for Rnt1p cleavage leading to degradation
Y
0.006
protein_40_YOL069W
SK.[LEH][SNM] Ndc80 complex
37
(Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome
condensed
clustering nuclear chromosome (0.001)
0.007
protein_40_YOL012C
2 HTZ1: Histone variant H2AZ, exchanged for histoneSE.[KD][EQG]N
37 complex;
[ST]E involved in transcriptional
G protein-coupled
regulation
receptor
throughkinase
prevention
1 substrate
of the spread
motifof silent heterochromatin
SWR1 complex (1e-06)
0.004
protein_40_YNR054C
2 ESF2: Essential nucleolar protein involved in pre-18S
E[ETY].D[QAV]
0.007
protein_40_YNL308C
2 KRI1: Essential nucleolar protein required for 40S ribosome
[GT][LNT]DIP
and functionally interacts with Krr1p
0.004
protein_40_YNL298W
2 CLA4: Cdc42p activated signal transducing kinase S[KDT]..[SW]NV
37 family,
S[ST]
involved in septinMDC1
ring assembly
BRCT and
domain
cytokinesis;
bindingdirectly
motif phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
0.004
protein_40_YNL289W
2 PCL1: Pho85 cyclin of the Pcl1,2-like subfamily, involvedP[PDN]P
37cycleQHR.P[PL]PP[GS]H[RH]
Motif recognized
localizes
by GYF
to sites
domains
of polarized cell growth
0.007
protein_40_YNL154C
[VKA]K..[TDM]L
37 K..[ST]
PKA
in morphogenesis,
kinase substrate
proper
motif
septin assembly,
Y
endocytic trafficking; provides an essential function overlapping with that of Yck1p
0.007
protein_40_YNL154C
2 YCK2: Palmitoylated, plasma membrane-bound casein Q..[STD]P
37 [ST]P
LIG_WW_4LIG_WW_4
in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p
0.007
protein_40_YNL118C
D[ERF].[VSE]Y
37 [EDY]Y
the 5' cap structureTC-PTP
from mRNAs
phosphatase
prior to theirsubstrate
degradation;
Y
motif
0.006
protein_40_YMR308C
2 PSE1: Karyopherin/importin that interacts with the nuclear
FG[QN]N[NG]
37nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.005
protein_40_YMR304W
2 UBP15: Ubiquitin-specific protease that may play a role
[GPM]SG[VRF]
in ubiquitin precursor processing
37
0.007
protein_40_YMR128W
2 ECM16: Essential DEAH-box ATP-dependent RNAT[DKR].[SRK]KR
37 predominantly
KR
nucleolar
CLV_PCSK_PC1ET2_1
in distribution, required for 18S rRNA synthesis
RNA processing (0.001)
0.004
protein_40_YMR047C
N.A[SKQ]
of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p;nuclear
homologous
pore
to (1e-36)
Nup100p
0.007
protein_40_YML049C
2 RSE1: Protein involved in pre-mRNA splicing; component
[EY]K.KK[VMP]
of the pre-spliceosome; 37
associates
P.[ST]PKK.KK
with U2 snRNA;Cdc2
involved
likeinprotein
ER to Golgi
kinase
transport
substrate motif
nuclear mRNA splicing, via spliceosome (1e-07)
0.004
protein_40_YLR429W
2 CRN1: Coronin, cortical actin cytoskeletal component
Q[IKP].[PIA]LS
37
0.004
protein_40_YLR372W
2 SUR4: Elongase, involved in fatty acid and sphingolipid biosynthesis;
W[LTF]F synthesizes 37
very long
LFG
chain 20-26-carbon
Protease
fatty acids
Papain
from C18-CoA
substrate,
primers;
a prototype
involved cysteine
in regulation
proteinase
of sphingolipid biosynthesis
Y
0.007
protein_40_YLR340W
EK..K[KRH][ELY]
37 shown
KR to be phosphorylated
CLV_PCSK_PC1ET2_1
on serine 302
nucleolus (0.01)
Y
0.005
protein_40_YLR287C-A
R[RA].[AFQ]R
to Rps30Bp
[AG]R
and has similarity
Protease
to rat S30
matriptase
ribosomalprotease
protein site
0.005
protein_40_YLR180W
2 SAM1: S-adenosylmethionine synthetase, catalyzesI[SMY].K[NFI]L
of ATPIY
cFGR
methionine;
and Csk
onekinase
of two differentially
phosphorylation
regulated
siteisozymes
(peptide(Sam1p
screen)
and Sam2p)
Y
0.004
protein_40_YLR106C
2 MDN1: Huge dynein-related AAA-type ATPase (midasin),
K[VQY]E[KH]E
forms extended pre-60S37
particle[VILMAFP]K.E
with the Rix1 complex
MOD_SUMOMOD_SUMO
(Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm
Y
0.004
protein_40_YLR002C
2 NOC3: Protein that forms a nuclear complex with Noc2p
[DVG]D.[EKQ]E
37precursors
D.E to mediate their
Sec24pSec24pSec24p
intranuclear transport; also binds to chromatin to promote the association of DNA replication cytoplasm
organization
0.007
protein_40_YKR001C
2 VPS1: Dynamin-like GTPase required for vacuolar LK..[KVD]L[ISD]
37
organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis
0.004
protein_40_YJR066W
E[VY]..V[EFS]N
37 that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis
0.004
protein_40_YJR022W
2 LSM8: Lsm (Like Sm) protein; forms heteroheptameric
F[LDN]..D[SR]V
Y
0.004
protein_40_YJL095W
2 BCK1: Mitogen-activated protein (MAP) kinase kinase[GMY]HP[SV]
kinase P[ST]
C signaling pathway,DNA
whichdependent
controls cellProtein
integrity;kinase
upon activation
substrate
bymotif
Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.005
protein_40_YIL133C
2 RPL16A: N-terminally acetylated protein componentR[AGW][AIP]R
37 [AG]R
Protease
has similarity
matriptase
to Rpl16Bp,
protease
E. coli L13
site and rat L13a ribosomal proteins; transcriptionally regulated
cytosolic
by Rap1p
Y
0.007
protein_40_YIL133C
2 RPL16A: N-terminally acetylated protein componentV[KVA][KRY]A
37 AEV[IVLF]YAA[PF]F
Abl
haskinase
similarity
substrate
to Rpl16Bp,
motif
E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated
cytosolic
by Rap1p
0.007
protein_40_YIL094C
S[KQW].V[PG]
37 forVP
Interleukin
biosynthesis
converting
of lysine, enzyme
in which homo-isocitrate
protease
0.005
protein_40_YIL061C
2 SNP1: Component of U1 snRNP required for mRNA
[LDK]L..[QKS]NY
0.004
protein_40_YIL018W
[ATG]R.[KGQ]A
37and has
[AG]R
similarity to E. coli
Protease
L2 and rat
matriptase
L8 ribosomal
protease
proteins;site
expression is upregulated at low temperatures
0.007
protein_40_YHR197W
2 RIX1: Essential component of the Rix1 complex (Rix1p,
[EMY][EKD]..EE
37for processing
[EDTY].YEE
of ITS2 sequences
Syk kinase
fromsubstrate
35S pre-rRNA;
motifRix1 complex associates with Mdn1p in pre-60S ribosomal particles
0.007
protein_40_YHR196W
Q[IGA]..[KLV]L
0.007
protein_40_YHR135C
2 YCK1: Palmitoylated, plasma membrane-bound casein A.[TSD]G
37
0.007
protein_40_YHL007C
2 STE20: Signal transducing kinase of the PAK (p21-activated
N.S[SVY]
kinase) family, involved
37in pheromone
N.[TS] response and
N-linked
pseudohyphal/invasive
glycosylation site
growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif bud
present
(0.01)
in noncatalytic domains of PAK kinases
0.007
protein_40_YGR274C
2 TAF1: TFIID subunit (145 kDa), involved in RNA polymerase
KQ.[ALE][LED]
37 has histone acetyltransferase activity, involved in promoter binding and G1/S progression
0.007
protein_40_YGR274C
2 TAF1: TFIID subunit (145 kDa), involved in RNA polymerase
QK[ADT][LI]E
37 has W[KDN]..K[KRE][LI]E[RKN]
CECROPIN
activity, involved
PATTERN
in promoter binding and G1/S progression
0.004
protein_40_YGR218W
[AGD][FSY].FG
37 from
LFG
the nucleus
Y
0.007
protein_40_YGR218W
N[NPV].[FIR]G
37 from the nucleus
Y
Y
0.007
protein_40_YGR086C
[IT]VKD[LP]
37 associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
0.005
protein_40_YGL106W
2 MLC1: Essential light chain for Myo1p, light chain for[FRC]DD[EPQ]
37 DD.Y
Shb PTB
with
domain
Myo1p,binding
Iqg1p, and
motif
Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
Y
0.006
protein_40_YGL103W
2 RPL28: Ribosomal protein of the large (60S) ribosomalK..[AKR]A
coli L15
K[KR].[KR]
Nuclear
proteins;
localization
may have
motif
peptidyl transferase activity; can mutate to cycloheximide resistance cytosolic ribosome (sensu Eukaryota) (1e-40)
Y
0.007
protein_40_YGL051W
2 MST27: Putative integral membrane protein, involved[IE]L.V[GQ]S
in vesicle formation; forms complex
37
with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.004
protein_40_YGL031C
2 RPL24A: Ribosomal protein L30 of the large (60S) ribosomal
[EHW]K[RMH]A
37 to Rpl24Bp
KR
and has similarity
CLV_PCSK_PC1ET2_1
to rat L24 ribosomal protein; not essential for translation but may be required for normal translation
cytosolicrate
large ribosomal subunit (sensu Eukaryota) (1e-10)
0.005
protein_40_YGL019W
2 CKB1: Beta regulatory subunit of casein kinase 2, a[AQK]L.YL[EV]
37 in cell
Y[LI]
SH2 ligand
the holoenzyme
for PLCgamma1
also contains
N-term.)group
CKA1, CKA23(phospho-peptide)
and CKB2, the many substrates include transcription factors and all RNA polymerases
0.004
2 LSB3: Protein containing a C-terminal SH3 domain; [QYA][LGD]QQ
binds Las17p, which is a homolog
37 of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
0.006
protein_40_YFL037W
2 TUB2: Beta-tubulin; associates with alpha-tubulin (Tub1p
[TVY]Q.[VQA]V
37dimer,
[ST]Q
which polymerizesATM
to form
kinase
microtubules
phosphorylation site
Y
0.006
protein_40_YFL037W
T[IR].A[GQV]
0.005
protein_40_YER177W
[PST][PS]KSP
37bindsSP
proteins and DNA,ERK1,
involvedERK2
in regulation
Kinaseofsubstrate
many processes
Y
0.004
protein_40_YER148W
2 SPT15: TATA-binding protein, general transcription factor
[SHF]L.DY[VR]
that interacts with other factors
37 to
DYR
cCbl
complex
and Cbl-b
at promoters,
TKB domain
essential
binding
for viability
motif for Met receptor, Tyr must be PO4
histone acetyltransferase complex (1e-06)
0.004
protein_40_YER112W
S[LGQ]..[DHE]SL
0.005
protein_40_YER074W
S.[LSR]S
37 and
S..S
Casien
S24 ribosomal
kinase I protein
phosphorylation site, 1st Ser must be phosphorylated
0.007
protein_40_YDR388W
2 RVS167: Actin-associated protein, subunit of a complexL..[GYP]D
37 in regulation
LG.GD of actin cytoskeleton,
Aspartyl protease
endocytosis,
active
and site
viability
in Presenilin
following starvation
also a YD
or osmotic
motif stress; homolog of mammalian
actin
amphiphysin
cytoskeleton (0.001)
Y
0.006
protein_40_YDR388W
2 RVS167: Actin-associated protein, subunit of a complex
P[SAQ]..[SVT]AA
37 in regulation
P[ST] of actin cytoskeleton,
DNA dependent
endocytosis,
Protein
andkinase
viabilitysubstrate
motif or osmotic stress; homolog of mammalian
actin
amphiphysin
cortical patch (1e-04)
0.005
protein_40_YDR365C
2 ESF1: Nucleolar protein involved in pre-rRNA processing;
RG[GPR][RIM]
depletion causes severely
37decreased
GGRGG
18S rRNA levels
Arginine methyl transferease substrate motif (PRMT1)
nucleolus (1e-04)
0.006
protein_40_YDR356W
E[LIH][ELK]E
37 involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated byspindle
Mps1p inpole
body (1e-25)manner
0.007
protein_40_YDR145W
[SKH]..EN
37 KEN
LIG_APCC_KENbox_2
and in chromatin modification, similar to histone H2A
0.007
protein_40_YDL140C
[DSN]E[DMG]D
37 of E[ST]D
Ankyrin
repeat
G domain
bindingregulates
motif in association
KNCQ2 and
withKNCQ3
transcription
potaqssium
and splicing
channels
factors; similar to bacterial
nucleoplasm
beta-prime (1e-19)
0.007
protein_40_YDL075W
G[KIY]K[VAY]
to Rpl31Bp
G[KR][KR]
and has similarity
Amidation
to rat L31after
ribosomal
cleavage
protein;
after
associates
Gly
Y (must
with be
the in
karyopherin
secretorySxm1p
pathway)
0.007
protein_40_YDL060W
2 TSR1: Protein required for processing of 20S pre-rRNA
[GRT]R[GFD]G
in the cytoplasm, associates
37with RGG
pre-40S ribosomal particles
Alternative integrin binding site in FMDV virus
0.006
protein_40_YDL055C
[IRG]AL[DTQ]
guanyltransferase),
Y
0.007
protein_40_YDL055C
L.[QEP]G
guanyltransferase),
37 synthesizes
P.L.P GDP-mannose
motiffrom
for interaction
with MYND domain
in cell
of BS69
wall biosynthesis; required for normal cell wallproteasome
structure
regulatory particle, base subcomplex (sensuYEukaryota) (1e-04)
0.007
protein_40_YDL029W
2 ARP2: Essential component of the Arp2/3 complex, which
[VP]P.[DPM]L
is a highly conserved actin
37 nucleation
P.DLScenter required
Binding
for themotif
motility
onand
TGIF
integrity
for CtBP
of actin patches; involved in endocytosis and membrane growth and polarity
Y
0.005
protein_40_YCR086W
2 CSM1: Nucleolar protein that forms a complex with Lrs4p
[LQ]P.I[TH]
which binds Mam1p at kinetochores
37 PWIduring meiosis Motif
I to mediate
in SRM160
accurate
forchromosome
binding DNA
segregation,
Y and RNAmay be involved in premeiotic DNA replication; possible role in telomere maintenance
0.005
protein_40_YCR086W
2 CSM1: Nucleolar protein that forms a complex with Lrs4p
Y[SFA].Q[SAP]
which binds Mam1p at kinetochores
37 Y..Qduring meiosis LIG_SH2_STAT3
I to mediate accurate chromosome segregation,
Y
may be involved in premeiotic DNA replication; possible role in telomere maintenance
0.004
protein_40_YBR247C
2 ENP1: Protein associated with U3 and U14 snoRNAs,K[LIY][RW]A
37 and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
0.006
protein_40_YBL026W
[RHG]E..R[LQ]R
0.004
protein_40_YAL032C
[ESQ][EPV]..NSS
37 interacts
S[ST]
MDC1
Prp22p
BRCT
and
domain
Prp46p;binding
orthologous
motifto human transcriptional coactivator SKIP and can activate transcription of a reporter gene
Y
0.004
protein_40_YAL032C
NT[QSE]
37 interacts
TEY with splicing factors
MEK Prp22p
phosphorylation
and Prp46p;oforthologous
MAPK activation
to humansites
transcriptional
- stringent
coactivator SKIP and can activate
spliceosome
transcription of
(1e-08)
a reporter gene
Y
0.007
oshea_ER
2 oshea_ER
F..[AIV]V
37
Y
0.007
oshea_cytoplasm
2 oshea_cytoplasm
Y..G
37 Y..GL
Tyr-based receptor endocytosis motif, noncanonical
0.007
2 oshea_cell_periphery
[TPF]T.[LKA]N
37
0.007
oshea_ambiguous
2 oshea_ambiguous
[KFG]LY[GMR]L
37 NKLY
0.005
N.Q[AQS]
37
Y
Y
0.009
matsuyama_ER
2 matsuyama_ER
[AGI]Y[GYF]L
37
0.009
matsuyama_Cytosol
2 matsuyama_Cytosol
A.L[SED]
37 GTALL
Receptor recycling motif
Y
ATP binding (1e-09)
Y
0.009
genetic_YLR262C
2 YPT6: GTPase, Ras-like GTP binding protein involved inK..[NKD]L
37 for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity
chromatin
to the human
modification
GTPase, Rab6
(1e-15)
0.007
genetic_YLR262C
2 YPT6: GTPase, Ras-like GTP binding protein involved in L.S[LKI]
37 for
WLNS
Lipid binding
vesicles
motifwith
in C-terminus
the late Golgi,ofmaturation
Apolipoprotein
of the vacuolar
AII
carboxypeptidase Y; has similarity
chromatin
to the human
modification
GTPase, Rab6
(1e-18)
0.007
genetic_YLR200W
D..[FNE]L
37folding
[DE]...L[LI]
AP complex
and
deleucine
actin
sorting motif
0.006
genetic_YLR200W
KK[LTH]
37folding
KKKKKK[ST]
TGF beta receptor
and actin kinase substrate motif
Y
0.007
genetic_YLR200W
T[LQV]Q
37folding
PTL
Motif in Fos
and
foractin
proteosome degredation
0.007
genetic_YLR039C
GN[NEY]
37 [GD][FYWA]G[LIVM][LIVMFYD]G[KN][NHW]
with Rgp1p that actsCAP_GLY_1
as a GTP exchange
PATTERN
factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.007
genetic_YLR039C
2 RIC1: Protein involved in retrograde transport to the SQ..[YKE][ILK]
cis-Golgi network; forms heterodimer
37 SQ
with Rgp1p that actsATM
as a kinase
GTP exchange
substrate
factor
motif
for Ypt6p;Yinvolved in transcription of rRNA and ribosomal protein genes
0.007
genetic_YGL058W
2 RAD6: Ubiquitin-conjugating enzyme (E2), involved in postreplication
E..E[TNF] repair (with Rad18p),
37 RE..E
Ironsilencing,
bindingand
motif
ubiquitin-mediated
in ferritin L-chain
N-end
and
rule
yeast
protein
Iron
degradation
transport(with
protein
Ubr1p)
Y
0.007
genetic_YGL058W
L.D[IET] repair (with Rad18p),
37 LPDEL
Motif
silencing,
in CBPand
forubiquitin-mediated
interaction with N-end
PPARg-LBD
rule protein
(secondary
degradation
site)
(with Ubr1p)
0.006
genetic_YER083C
2 GET2: Subunit of the GET complex; required for meioticS..L[EQT]
genetic_YAL024C
2 LTE1: Putative GDP/GTP exchange factor required for mitotic
N[IGS]N
cell cycle
with Ras2p-GTP
(1e-19)
0.007
protein_40_YBR160W
S[DPQ].[DNK]DS
37
bud (0.001)
0.006
protein_40_YDL188C
2 PPH22: Catalytic subunit of protein phosphatase 2A, functionally
[TIV][FH]SP
redundant with Pph21p;
36 SP
ERK1,forms
ERK2
alternate
Kinasecomplexes
substratewith
motif
Yseveral Proteasome
1.E-12
-4.5
proteasome
and regulationcore
of mitosis
complex, alpha-subunit complex (sensu
Y Eukaryota) (1e-16)
0.005
protein_40_YDL188C
2 PPH22: Catalytic subunit of protein phosphatase 2A, EY.[LS]E[AS]
functionally redundant with Pph21p;
36 [DE]Y
EGFRforms
kinase
alternate
substrate
complexes
motif withYseveral Proteasome
1.E-10
-4.1
proteasome
and regulationcore
of mitosis
complex (sensu Eukaryota) (1e-09) Y
0.004
protein_40_YPL031C
2 PHO85: Cyclin-dependent kinase, with ten cyclin partners;
SS[PTG]
36cellular
S[ST]
response to nutrient
MDC1
levels
BRCT
and environmental
domain binding
conditions
motif and progression
Cyclinthrough the cell
1.E-09
cycle
-2.1
cyclin-dependent protein kinase regulator activity (1e-18)
0.007
protein_40_YDR099W
2 BMH2: 14-3-3 protein, minor isoform; controls proteome
N[NYM]..S[SED]
36bindsS[ST]
involvedBRCT
in regulation
domain
of many
binding
processes
motif including
Pkinase
exocytosis, vesicle1.E-02
transport, Ras/MAPK
-1.7 signaling,
phosphotransferase
and rapamycin-sensitive
activity,
signaling
alcohol group as acceptor (0.01)
0.007
protein_40_YPL093W
H[RGF]..R[TGK]
36
and is required for 60S ribosomal subunit biogenesis; constituent of 66S
DEAD
1.E-10 member
-1.6
of the ODN
ribosomal
family of nucleolar
large subunit
G-proteins
assembly and maintenance (1e-11)
0.006
oshea_nucleus
2 oshea_nucleus
Q[QEK]Q
36
zf-C2H2
1.E-03
-1.6
Y
0.007
yeast-468_GO-0051276
2 chromosome organization and biogenesis
E.D[ELG]
36 AEVD
Protease Caspase 10
Bromodomain
1.E-03
-1.4
Y
0.008
yeast-345_GO-0006396
2 RNA processing
AR..D[IFS][PLR]
36 [AG]R
DEAD
1.E-06
-1.4
0.006
yeast-220_GO-0044255
V[ITA]..L[IAF]
36
PAP2
1.E-02
-1.4
0.008
10
10
10
10
10
10
10
7
8
10
10
10
10
7
9
10
10
10
10
10
9
10
10
9
9
10
10
10
9
9
7
8
10
9
9
10
8
9
10
10
10
8
7
10
10
10
9
8
10
10
10
7
9
10
9
10
7
7
10
8
9
7
9
10
10
10
7
10
10
10
10
10
10
7
10
10
7
9
9
8
9
7
10
10
10
8
7
9
10
10
8
10
10
10
10
10
8
10
10
7
8
9
10
8
7
10
10
10
10
7
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
8
9
10
10
10
10
10
9
10
protein_40_YIL035C
oshea_bud_neck
protein_40_YPL131W
protein_40_YOL012C
protein_40_YPL153C
protein_40_YDL148C
yeast-513_GO-0005515
yeast-460_GO-0006351
protein_40_YMR047C
protein_40_YGR128C
yeast-593_GO-0031981
protein_40_YKL203C
yeast-235_GO-0000278
yeast-752_GO-0016787
yeast-1134_GO-0044249
yeast-251_GO-0005886
protein_40_YML085C
protein_40_YOL133W
oshea_bud_neck
yeast-341_GO-0045449
yeast-939_GO-0051234
protein_40_YOR181W
yeast-251_GO-0005886
protein_40_YGR128C
yeast-244_GO-0000279
protein_40_YER082C
protein_40_YBR159W
protein_40_YMR001C
yeast-685_GO-0016740
yeast-235_GO-0009653
yeast-235_GO-0000902
yeast-238_GO-0017111
protein_40_YLR180W
yeast-706_GO-0043412
yeast-649_GO-0003676
protein_40_YER110C
yeast-942_GO-0043232
yeast-942_GO-0043228
protein_40_YJR059W
protein_40_YIL094C
yeast-235_GO-0000278
yeast-235_GO-0009653
yeast-685_GO-0016740
yeast-235_GO-0000902
yeast-335_GO-0016772
protein_40_YPL240C
protein_40_YNL272C
protein_40_YLR186W
protein_40_YMR229C
yeast-462_GO-0019222
protein_40_YGR128C
yeast-648_GO-0050791
yeast-335_GO-0016772
yeast-256_GO-0016462
protein_40_YAR019C
yeast-752_GO-0016787
protein_40_YDL153C
yeast-1340_GO-0044267
matsuyama_Cytosol
yeast-649_GO-0003676
protein_40_YGL120C
yeast-649_GO-0003676
yeast-436_GO-0031323
yeast-792_GO-0006412
yeast-648_GO-0050791
yeast-470_GO-0006259
yeast-457_GO-0007001
yeast-376_GO-0019219
yeast-343_GO-0005198
yeast-336_GO-0005783
yeast-267_GO-0000003
yeast-267_GO-0000003
yeast-267_GO-0000003
yeast-240_GO-0006807
yeast-223_GO-0003735
yeast-207_GO-0006974
ubiquitin_peng2003
protein_40_YPR182W
protein_40_YPR120C
protein_40_YPR034W
protein_40_YPL240C
protein_40_YPL217Cs
protein_40_YPL204W
protein_40_YPL204W
protein_40_YPL131W
protein_40_YPL126W
protein_40_YPL090C
protein_40_YPL042C
protein_40_YPL004C
protein_40_YOR181W
protein_40_YOR096W
protein_40_YOR061W
protein_40_YOR061W
protein_40_YOL139C
protein_40_YOL133W
protein_40_YOL086C
protein_40_YOL041C
protein_40_YOL018C
protein_40_YOL013C
protein_40_YNL308C
protein_40_YNL154C
protein_40_YNL069C
protein_40_YMR308C
protein_40_YMR304W
protein_40_YMR288W
protein_40_YMR216C
protein_40_YMR215W
protein_40_YMR047C
protein_40_YML073C
protein_40_YML069W
protein_40_YML010W
protein_40_YML007W
protein_40_YLR429W
protein_40_YLR222C
protein_40_YLR222C
protein_40_YLR180W
protein_40_YLR180W
protein_40_YLR180W
protein_40_YLR180W
protein_40_YLR009W
protein_40_YKL203C
protein_40_YKL180W
protein_40_YKL145W
protein_40_YJR145C
protein_40_YJL164C
protein_40_YJL138C
protein_40_YJL092W
protein_40_YJL074C
protein_40_YJL033W
protein_40_YJL010C
protein_40_YIL069C
protein_40_YIL035C
protein_40_YIL016W
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
CKA1: Alpha catalytic subunit of casein kinase 2, a Ser/Thr
K..R[KIG]
36in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1Histone
and CKB2, the many
1.E-04
substrates include
-1.2 transcription
nuclearfactors
lumen
and(1e-12)
all RNA polymerases
Y
0.007
10
-1.2
Y
0.007
10
-1
0.007
10
-1
nuclear nucleosome (1e-08)
0.004
8
RAD53: Protein kinase, required for cell-cycle arrest in QQ..[PDQ]
1.E-02with ARS1
-0.9and plays
cellacortex
role in initiation
part (0.001)
of DNA replication
0.007
10
NOP14: Nucleolar protein, forms a complex with Noc4pK..K[RLQ]
36 nuclear
CLV_PCSK_PC1ET2_1
subunits; also present in the small subunitWD40
processome complex,
1.E-05
which is required
-0.9 for cytoplasm
processing of organization
pre-18S rRNA and biogenesis (1e-35)
0.007
10
protein binding
S[TKL][IAY]E
36 [KRHEQSTAG]G[FYLIVM][ST][LT][LIVP]E[LIVMFWSTAG]
N-terminal methylation site in prokaryotes. Residue
HEAT after G is1.E-02
methylated -0.8
0.008
10
TT[ANR]
zf-C2H2
1.E-04
-0.8
Y
0.008
10
NUP116: Subunit of the nuclear pore complex (NPC) thatIA[NFQ]
of the FED[LV]IA[DE][PA]
CAVEOLIN
GLFG motif
PATTERN
that interacts with mRNA exportIBN_N
with karyopherin
-0.7
Kap95p;nuclear
homologous
pore
to (1e-26)
Nup100p
Y
0.007
10
UTP8: Nucleolar protein required for export of tRNAs[LSQ]T[GLI]Q
36 with
STG
EH(3)processome
EF hand domain
containing
binding
the U3motif
snoRNA
of EPS15,
that WD40
is involved
Class in
II processing
1.E-02
of pre-18S
-0.6
rRNA rRNA processing (1e-12)
0.007
10
nuclear lumen
I[NRL]K
36 RRT[IV][ATN]KYR
SIGMA54_2 PATTERN
Helicase_C
1.E-03
-0.4
0.008
10
SD..[GPL]T[LM]
36 thatSD.E
regulates growth inCasein
response
kinase
to nutrients
II substrate
and TORC2,
motif a complex
Cation_ATPase_N
that regulates cell-cycle
1.E-02
dependent polarization
-0.4
ATPase
of the actinactivity,
cytoskeleton;
coupled
involved
to intransmembrane
meiosis
movement of ions, phosphorylative
0.004
mechanism
9
(0.001)
mitotic cell cycle
KR[KLR]
36 KR
CLV_PCSK_PC1ET2_1
HEAT
1.E-03
-0.2
0.008
10
hydrolase activity
SK[IYW]
36 ES[RK][FY][YST]FH[PS][IV][ES]D
LIG_WH1LIG_WH1
ABC_tran
1.E-06
0.1
Y
0.008
10
cellular biosynthesis
[HRA].AG
36 GR.A
Protease tPA proteolytic site
Ribosomal_60s
1.E-04
0.1
0.008
10
plasma membrane
P..W[VLP]
36
Y
MFS_1
1.E-06
0.2
0.008
10
[DPL]EL[NTL]
36 polymerizes
LPDEL to form microtubules
Motif in CBP for interaction with Y
PPARg-LBDHEAT
0.3
microtubule (0.01)
Y
0.007
10
T.T[TSI]
36(SCF);
[KR].TQT
required for Gic2p,LIG_Dynein_DLC8_1
Far1p, Sic1p and Cln2p degradation; may tether Cdc34p
conjugating enzyme
0.4 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(1e-12)
of SCF
0.007
10
oshea_bud_neck
E..K[RFT]
36 KR
CLV_PCSK_PC1ET2_1
RhoGAP
1.E-04
0.5
bud (1e-51)
Y
0.007
10
E.[KQT]P
Zn_clus
1.E-06
0.6
Y
0.008
10
F..[VAL]F
36 F..LF
MFS_1
1.E-10
0.7
Y
0.008
10
DG.[YTM][DRH]
branched actin filaments; localizes with the Arp2/3 complex to actin patches;Pkinase
homolog of the human
1.E-02
Wiskott-Aldrich
0.7syndrome
endocytosis
protein (WASP)
(1e-04)
0.005
10
plasma membrane
F.G[YLT]
Sugar_tr
1.E-05
0.8
0.008
10
[NQP]G.L[KEN]
36 with
G[SA]LNK
GDP-mannose
processomebinding
containing
motif
thein
U3transporter
snoRNA that WD40
1.E-04
of pre-18S0.8
0.007
10
M phase
I.D[LVD]
36
MutS_III
1.E-03
0.9
M phase (1e-17)
0.008
10
KV[LIW][TKD]
WD40
1.E-04
0.9
0.007
10
IFA38: Microsomal beta-keto-reductase; contains oleate response
FT[MFL]
36 F..F[ST][FY]
Rsks mutants
are phosphorylated
exhibit reducedatVLCFA
this Y
bulky
synthesis,
ring Sugar_tr
site,
accumulate
Ser/Thr
high
must
levels
1.E-02
beofphosphorylated.
dihydrosphingosine,
0.9 This
endoplasmic
phytosphingosine
motif recruits
reticulum
and
PDK1
medium-chain
kinase
(1e-05)ceramides
0.007
10
DF.[LDM][DA]
at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis
Pkinase
through phosphorylation
1.E-02 of substrates;
1
may
M phase
be a Cdc28p
(1e-04)
substrate
Y
0.006
10
F..E
36
Pkinase
1.E-47
1.2
Y
(1e-14)0.007
10
morphogenesis
D[SVG].[VSH]L
36
Pkinase
1.E-02
1.4
Y
0.007
10
D[SVG].[VSH]L
36
Pkinase
1.E-02
1.4
Y
0.007
10
[SDC]A.T[GQI]
36
Ras
1.E-08
1.5
Y
0.008
10
SAM1: S-adenosylmethionine synthetase, catalyzes[GLT]I..G[RHV]
of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes
Sam2p)
1.5
Y
0.007
10
[GLK]P..TP[YLG]
36 [ST]P
LIG_WW_4LIG_WW_4
UQ_con
1.E-12
1.6
0.008
10
R[LGC].[RFN]RG
36 [KR]R
CLV_PCSK_KEX2_1
Y
Histone
1.E-05
1.6
Y
0.008
9
KAP123: Karyopherin beta, mediates nuclear import[LNF]A[RAW]R
assembly
[KR]R
into ribosomes and
CLV_PCSK_KEX2_1
import of histones H3 and H4; localizes to the nuclear
Histone
pore, nucleus,
1.E-05
and cytoplasm;
1.6
exhibitsnuclear
nucleosome
with RAI1
(1e-04)
0.007
9
LF[HYG]
36 LFG
Protease Papain substrate, a prototype
Y
cysteine
UCHproteinase 1.E-02
1.8
0.007
10
LF[HYG]
36 LFG
Y
cysteine
UCHproteinase 1.E-02
1.8
0.007
10
PTK2: Putative serine/threonine protein kinase involvedG.[THP]P
36across
[ILVM]LG..P
plasma membrane;
LIG_RRM_PRI_1
Pkinase
1.E-04
1.8
Y
0.007
10
[LGE][SKE]..LA
36 for the fourth step in the biosynthesis of lysine, in which homo-isocitrate IBN_N
is oxidatively decarboxylated
1.E-02 to alpha-ketoadipate
1.9
0.007
10
mitotic cell cycle
[SEC]L..L[GKM]
36
Kinesin
1.E-04
2
0.008
10
morphogenesis
K[PQ][DSH]N
36
Pkinase
1.E-03
2.1
Y
0.008
9
L..[KPW]Y
36
Pkinase
1.E-08
2.2
Y
(1e-47)0.008
10
K[PQ][DSH]N
36
Pkinase
1.E-03
2.2
Y
0.008
9
H.N[NIL]
36 DHKNLD.D
PTPS_2 PATTERN
Pkinase
1.E-48
2.3
Y
(1e-91)0.008
10
EN[LIQ]
36of Hsf1p;
KENdocks with Tom70p
LIG_APCC_KENbox_2
for mitochondrial preprotein delivery; promotes
Pkinase
2.5 addition;
kinase
interacts
activity
with
(0.001)
Cns1p, Cpr6p, Cpr7p, Sti1p
0.006
10
SEC2: Guanyl-nucleotide exchange factor for the smallGV[IF][LT]Y
36cytoplasmic
FTYP vesicles; essential
Docking
for post-Golgi
motif on c-Fos
vesiclefor
transport
Erk
Pkinase
1.E-06
2.5
0.004
9
EMG1: Protein required for the maturation of the 18SA[TV]..[YAH]D
production; associated with spindle/microtubules; nuclear localization
Y dependsWD40
1.E-03
with Nop14p;
2.6may bind
snoRNA
snoRNAs
binding (1e-13)
Y
0.005
10
K[PAM]..LL[LTN]
36 is[DE]..LL
Di-Leu
of 18S
acidic
rRNA
motif
and for
N-terminal
receptor
region
endocytosis
is required
Pkinase
(recognized
for the 5.8S rRNA;
by VHS
1.E-04
component
domainofofsmall
3.1
GGA
ribosomal
proteins)
protein
subunit
kinase
(SSU)
activity
processosome
(0.001)
0.005
8
L.Q[DHE]
36 LSQE
Y
zf-C2H2
1.E-05
3.2
Y
0.008
10
A[TVS]..[YAH]D
36 with the small subunit (SSU) processome containing the U3YsnoRNA that WD40
1.E-05
of pre-18S3.2
Y
0.005
8
[IYQ]..DIK
36 P.Q..D
LIG_TRAF2_2
Pkinase
1.E-08
3.4
0.008 (1e-12)9
L.H[PKF]
36
Y
Pkinase
1.E-36
3.7
Y
(1e-97)0.008
10
[RFQ]EL[APR]
36 [KRHQSA][DENQ]EL
ER_TARGET PATTERN
DEAD
1.E-12
4.2
Y
0.008
10
[GKN]..HR
1.E-21
4.2
Y
0.007
10
hydrolase activity
[LRF][YF].PPG
36
AAA
1.E-15
4.3
0.007
9
W.[ILMV]G
Pkinase
disrupts silencing
1.E-18
4.4
0.007
10
[VAY]K..D[FLA]G
36
Pkinase
1.E-24
4.9
0.008
10
matsuyama_Cytosol
Y..P[EKV]
36 Y..P
SH2 ligand group 1B-Crk, SH2 binding motif
Pkinase
for ITK, Nck and1.E-13
RasGAP to Doc-R
5
(needs
purine
to nucleotide
be Tyr phosphorylated)
binding (1e-13)
Y
0.009
10
[CIV]NA[CQI]G
36
GATA
1.E-11
6.2
0.007
9
GR.[AGN][RKA]
I and polymerase
[AG]R II transcript
Protease
metabolism,
matriptase
involved protease
in release of
site
the lariat-intron
Helicase_C
1.E-06
6.8
nucleolus (1e-09)
0.007
10
R..K[QKC]
36 R..K
SH3 binding motif for GADS SH3 recognizing
Zn_clus
1.E-07
9.5
0.008
10
CR..K[ITE][KGA]
36 R..K
Y recognizing
Zn_clus
1.E-11
13.2
Y
0.007
9
K[AWF].[KAQ]A
36
translation (1e-52)
0.008
10
Q..E[KTD]
36
0.008
10
DNA metabolism
K[EFP].Q[QIS]
36
0.008
9
E[EKH].D[ESW]
36
10
regulation of nucleobase, nucleoside, nucleotide andE[ENT][DLG]EV
36 [YL]EVD
Protease Caspase 1 and 4
Y
0.008 (1e-18)
10
L.[GQP]I
36 PL[ST]PIP[KRH]CDK4 kinase substrate motif
0.008
10
F.I
36 F.[IV][WFY][WFY][IL][ILM]
EH1 motif binds to groucho/TLE corepressors
endoplasmic reticulum (10)
Y
0.008
10
reproduction
[PFD]Y[QET]L
36 [EDY]Y
TC-PTP phosphatase substrate motif
0.008
10
reproduction
P[AYQ]..[PGV]P
36 GP
Y
0.008
10
reproduction
TT[KGT][IHW]
36 YTT[ILM]
Syk N-terminal SH2 domain binding motif
0.008
10
AD[IHT][QVF]
36
0.008
10
A[KVN]..KK[VWR]
36 KR
CLV_PCSK_PC1ET2_1
structural constituent of ribosome (1e-11)
0.006
9
[EIC]NE[DVR]
36
0.007
10
ubiquitin_peng2003
LL.[FGN][TVS]I
36 LLG
0.007
10
SMX3: Core Sm protein Sm F; part of heteroheptameric
LL.L[SCA][KNH]
complex (with Smb1p, Smd1p,
36 Smd2p,
LLG Smd3p, Sme1p,
Beta2-Integrin
and Smx2p) that
binding
is partmotif
of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human
nuclear
Sm F mRNA splicing, via spliceosome (1e-08)
0.004
8
CLB5: B-type cyclin involved in DNA replication during
[EMT]E.E[EIY]
to promote
EEEYF
initiation of DNAEGFR
synthesis;
kinase
functions
phosphorylation
in formation ofsite
mitotic
(peptide
spindles
screen)
along with Clb3p and Clb4p; most abundant during late G1 phase
0.007
10
ARP7: Component of both the SWI/SNF and RSC chromatin
[QG]L.K[LQ]N
remodeling complexes;
36 actin-related
KEN protein involved
LIG_APCC_KENbox_2
in transcriptional regulation
chromatin remodeling complex (0.001)
0.004
9
L.E[TVI]
36of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition;
protein
interacts
folding
with(0.01)
Cns1p, Cpr6p, Cpr7p, Sti1p
0.006
10
BMS1: Essential conserved nucleolar GTP-binding protein
[ETD]E.[INF]A
3640S ribosomal
[ST]E subunits and
G protein-coupled
for processing of the
receptor
35S pre-rRNA
kinaseat1sites
substrate
A0, A1,motif
and A2; interacts with Rcl1p, has similarity
rRNA
to Tsr1p
processing (1e-17)
0.007
10
HRR25: Protein kinase involved in regulating diverse[TVP]KTS[IKF]
36
DNA repair, and chromosome segregation; binds the CTD
Y of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
0.004
7
HRR25: Protein kinase involved in regulating diverseDE[NV][SHI]K
36 YDE[PDV]
SH2 ligandsegregation;
for Nck1 and
binds
Nck2
the CTD
(Tyrofmust
RNAbe
polphosphorylated)
II; homolog of mammalian casein kinase 1delta (CK1delta)
0.004
7
R[EKT][LVI]A
coli L18MR[DE][IL]
TUBULIN_B_AUTOREG
proteins; binds 5S rRNA and
PATTERN
is required for 60S subunit assembly
0.007
10
NAN1: U3 snoRNP protein, component of the smallR[HRW]..F[LND]
36 W..Fcontaining U3 snoRNA;
VPR binding
required
motif
for the
in uracil
biogenesis
DNAof18S
glycosylase
rRNA
nucleolus (1e-08)
0.005
10
DV..I[EIK][LNV]
0.004
8
SSN3: Cyclin-dependent protein kinase, component of
P[QPT]Y[IVF]
RNA polymerase II holoenzyme;
36 involved
NP.Y in phosphorylation
LIG_PTB_1LIG_PTB_1
of the RNA polymerase II C-terminal domain; involved in glucose repression
0.005
9
IE.[GK][DC]
36at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways
0.004
8
N[FPV]AS[TG]
branched
S[ST]
MDC1 BRCT
with thedomain
Arp2/3 complex
bindingtomotif
actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
Y
0.004
7
K[LIK][RAV]A
36Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal
ribonucleoprotein
proteins
complex (1e-17)
Y
0.007
10
CKA2: Alpha' catalytic subunit of casein kinase 2, a[KVQ][RVF]..KP
RNA elongation
factors and from
all RNA
RNA
polymerases
0.007
9
CKA2: Alpha' catalytic subunit of casein kinase 2, a [LHD]V..E[DSY]
RNA polymerase
factors and allIIRNA
transcription
polymeraseselongation factor activity (1e-05)
0.007
10
CDC33: Cytoplasmic mRNA cap binding protein; the eIF4E-cap
I[TR].Q[DA]L
complex is responsible
36 for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p)
0.004
10
V[IPN]E[IPW]
36(SCF);
VP
required for Gic2p,Interleukin
Far1p, Sic1p
converting
and Cln2p enzyme
degradation;
protease
may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF
Y
0.007
10
ADH1: Alcohol dehydrogenase, fermentative isozyme
M[SLE]D[SLR]
36 DMQD
required for the reduction
Protease
of acetaldehyde
Caspase 3 to
-stringent
ethanol, the last step in the glycolytic pathway
Y
0.006
10
NOP12: Nucleolar protein, required for pre-25S rRNA
K[KEL]K[KRA]
36recognition
KKKKKK[ST]
motif (RRM) and
TGF
hasbeta
similarity
receptor
to Nop13p,
kinaseNsr1p,
substrate
and putative
motif orthologs in Drosophila and S. pombe
Y
0.007
10
TLG2: Syntaxin-like t-SNARE that forms a complex with
F[IMY][VTM]F
Tlg1p and Vti1p and mediates
Y Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation
0.004
8
HRD1: Ubiquitin-protein ligase required for endoplasmicD[QVA]V
36 [IVT][LIVMC][IVT][HS]D[SGAV][AV]R
(ERAD) of misfolded
ISPD
proteins;
PATTERN
genetically linked to the unfolded protein response (UPR); regulated through association
carboxylic
with Hrd3p;
acid
contains
metabolism
an H2 ring
(0.01)
finger
0.007
9
K[YS]L[SDE]E
and functionally
[ST]E interacts with
G protein-coupled
Krr1p
0.004
8
N[NDF]S
36 N.[TS]
N-linked
in morphogenesis,
glycosylation
proper
siteseptin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p
Y
0.006
10
RPL16B: N-terminally acetylated protein componentRA.[KRQ][VGA]
36
binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated
cytosolic
by Rap1p
Y
0.007
10
S[NAF]SF[TE]
36nuclear import receptor for specific proteins, including Pdr1p, Y
Yap1p, Ste12p, and Aft1p
0.004
8
UBP15: Ubiquitin-specific protease that may play a role
D[FYQ][DPY]G
36
Y
0.005
10
HSH155: U2-snRNP associated splicing factor that forms
EI.[VR]S[FL]
extensive associations with
36 the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated
nuclearsplicing
mRNA
factor
splicing,
SAP155via spliceosome (1e-04)
0.004
8
SKY1: SR protein kinase (SRPK) involved in regulatingG[ILMV]AV
proteins involved in mRNA36
metabolism and cation homeostasis; similar to human SRPK1
0.005
8
GAS3: Putative 1,3-beta-glucanosyltransferase, has similarity
I[LYS]Y[LTC]
to Gas1p; localizes 36
to the cell
Y[VLTFIC]
wall
LIG_SH2_STAT5
integral to membrane (0.001)
0.006
10
[KPT]K.K[SLR]R
of the [KR]R
CLV_PCSK_KEX2_1
GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p
Y
0.004
9
K..[RAK]A
36 has
K[KR].[KR]
Nuclear
and tolocalization
rat L6 ribosomal
motif
Y
0.007
10
GE[LYQ][ARD]
which facilitates
36 RNA[WFY]G[PDE][WFYLM]
Pol II transcription gamma-adaptin
elongation throughear
nucleosomes
binding motif
by destabilizing
Y
and then reassembling nucleosome structure;RNA
interacts
elongation
with DNA polymerase
from RNAalpha
polymerase
(Pol1p)
II promoter (0.001)
0.006
10
S.[AEQ]D
36
0.007
10
YAP1: Basic leucine zipper (bZIP) transcription factor required
Y[IN].R[LQ]
for oxidative stress 36
nucleoplasm
mediates resistance
part (1e-06)
to cadmium
0.004
8
CRN1: Coronin, cortical actin cytoskeletal component that
E..E[ATG]
associates with the Arp2p/Arp3p
36 RE..E
complex to regulate
Iron
its binding
activity; plays
motifain
role
ferritin
in regulation
L-chainofand
actinyeast
patch Iron
assembly
transport protein
endocytosis (0.001)
0.007
10
S..[SND]S
to Rps30Bp
S..[ST]
and has similarity
Casein
to ratKinase
S30 ribosomal
I consensus
protein phosphorylation site (N-term Ser must first be phosphorylated)
0.007
10
K[ERW]D[DT]
36 KR
is involved in processing of pre-18S rRNA
nucleolus (1e-05)
0.005
10
T[DHC][LQ]D
0.005
10
SAM1: S-adenosylmethionine synthetase, catalyzes I[KEC].V[GIV]
0.007
9
SAM1: S-adenosylmethionine synthetase, catalyzesLA.[NKA][DPT]
Y
0.007
10
P..[GKF]V
of ATPKP..[QK]
LIG_SH3_4LIG_SH3_4
methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
0.007
10
SAM1: S-adenosylmethionine synthetase, catalyzes
V[VTN]..[MVK]G
Y
0.006
10
RLP24: Essential protein with similarity to Rpl24Ap and
[ES]DD[DEG]
pre-60SDDDK[ACDEFGHIKLMNQRSTVWY]
ribosomal subunitsProtease
and required
Enterokinase
for ribosomal large subunit biogenesis
0.007
10
[GVD][QYG]..DS
36 thatR.DSPVR
regulates growth in14-3-3
response
binding
to nutrients
motif and
on N-terminal
TORC2, a complex
domainthat
of regulates
Nitrate Reductase
cell-cycle dependent
necessary
polarization
for 14-3-3
plasma
of the
binding
actinmembrane
cytoskeleton;
for inactivation
(1e-07)
involved
in the
in meiosis
dark
0.007
9
RPL17A: Protein component of the large (60S) ribosomalS.S[SNI]
to Rpl17Bp
R.S.S.P
and has similarity
14-3-3
to E. coli
binding
L22 and
motifs,
rat L17
Serribosomal
must beproteins;
phosphorylated
copurifies with the Dam1 complex (aka DASH complex)
0.007
10
TI[IMA][RQ]
36
in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the
proteasome
complex
ligase
(sensu
Ubr1p Eukaryota) (1e-04)
Y
0.005
10
S[KAE].A[AEQ]
20S pre-rRNA processing; identical to Rps4Bp and has similarityYto rat S4 ribosomal protein
0.007
10
TPK1: cAMP-dependent protein kinase catalytic subunit;T.[SEQ]P
36 in response
[ST]P to nutrients LIG_WW_4LIG_WW_4
via the Ras-cAMP signaling pathway;Yinhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p
Y
0.007
10
TIF2: Translation initiation factor eIF4A, identical to HL..[AWC][IMG]
Tif1p; DEA(D/H)-box RNA helicase
0.004
10
E.[SRA]S
for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing
response
unscheduled
to DNA damage
homologous
stimulus
recombination
(1e-04)
0.007
10
SMC3: Subunit of the multiprotein cohesin complex[RAM]EK[ASW]
36
Y
0.006
9
HCA4: Putative nucleolar DEAD box RNA helicase; high-copy
A..K[KIC]
number suppression36
of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
mRNA cleavage and polyadenylation specificity factor complex
Y
(1e-10)0.007
10
NOP9: Essential component of pre-40S ribosomes[MWQ]S..[SG]SL
36 of 35S
RSSLHL
pre-rRNA and hence
Motifformation
in beta-arrestin
of 18S rRNA;
2 forbinds
interaction
RNA in with
vitro and
Jnk3contains multiple pumilio-like repeats
Y
0.004
10
K[RYG]A
36 and
KRhas similarity to rat
CLV_PCSK_PC1ET2_1
Y
0.006
10
K[KER]..K[KIT]
36in cellK[KR].[KR]
Nuclear
thelocalization
holoenzyme also
motifcontains CKA2, CKB1 and CKB2, the many substrates include transcription
nucleolus
factors
(1e-09)
and all RNA polymerases
0.007
10
SNL1: Protein of unknown function proposed to be involved
[NGA][ELH].FF
in nuclear pore complex
36biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
0.005
9
oshea_bud_neck
T.D[TDL]
36
HSTSDD
Branched chain alpha-ketoacid dehydrogenase
RhoGAP
kinase substrate
1.E-03
motif
RPL5: Protein component of the large (60S) ribosomal E..E[DAG]
coli L18RE..E
Iron
proteins;
binding
binds
motif
5Sin
rRNA
ferritin
and L-chain
is required
and
foryeast
60S subunit
Brix
Iron transport
assembly protein
1.E-02
HTZ1: Histone variant H2AZ, exchanged for histone H2A
G[GW]V[KL]
1.E-10
protein_40_YHR203C
R[VAG].[GKI]G
protein_40_YHR041C
2 SRB2: Subunit of the RNA polymerase II mediator complex;
[NV]I.[NPK]NI
36
protein_40_YHL007C
2 STE20: Signal transducing kinase of the PAK (p21-activated
Y[APM].G[SN]
36in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases
protein_40_YGR085C
2 RPL11B: Protein component of the large (60S) ribosomalS.[SLI]S
to Rpl11Ap;
S..Sinvolved in ribosomal
Casien
assembly;
kinase Idepletion
phosphorylation
causes degradation
site, 1st Ser
of proteins
must be
andphosphorylated
RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
protein_40_YGR060W
2 ERG25: C-4 methyl sterol oxidase, catalyzes the first of
IL[YVI][LVF]
three steps required to remove
36 two
L[IVLMF][IVLMF][DE]
C-4 methyl groupsClathrin
from an box
intermediate
motif onincargo
ergosterol
adapter
biosynthesis;
proteinsmutants accumulate the sterol intermediate 4,4-dimethylzymosterol
protein_40_YGL147C
G[KIY]K[VAY]
Rpl9Bp
G[KR][KR]
and has similarity Amidation
to E. coli L6 after
and rat
cleavage
L9 ribosomal
afterproteins
Gly
Y (must be in secretory pathway)
protein_40_YGL120C
K[LER]SD[SVA]
I and polymerase
KR
II transcript
CLV_PCSK_PC1ET2_1
metabolism, involved in release of the lariat-intron from the spliceosome
protein_40_YGL120C
R[ACN][LEI]KT
I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
protein_40_YGL106W
2 MLC1: Essential light chain for Myo1p, light chain for
[RAS][LGN]..DLE
36 D.E
Sec24pSec24pSec24p
with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
Y
protein_40_YGL105W
GG[EA][LV]F
synthetases (Mes1p
36 and
FRGGT
Gus1p), deliveringPhosphoinositide
tRNA to them, stimulating
binding
catalysis,
motif inand
ATG18
ensuring
andtheir
ATG21
localization to the cytoplasm; also binds quadruplex nucleic acids
Y
protein_40_YGL076C
D[KQ]..[EH]DL
Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins;
Y
contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
protein_40_YER148W
[KPL]S.Q[SQ]S
36 to
S[QT]Q
ATM
complex
phosphorylation
at promoters,ofessential
this motif
for on
viability
Chk2
transcription factor complex (0.001)
protein_40_YER133W
2 GLC7: Catalytic subunit of type 1 serine/threonine protein
[DET]D..[SKP]S
36many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly
phosphatase
isolated
regulator
with Sds22p
activity (1e-07)
Y
protein_40_YER112W
[VFI]R.E[IFP]
protein_40_YER110C
2 KAP123: Karyopherin beta, mediates nuclear importAV..[AQF][IKG]
assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
Y
protein_40_YER021W
2 RPN3: Essential, non-ATPase regulatory subunit of E[EV]..[KLD]FT
36
to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
protein_40_YER018C
2 SPC25: Component of the evolutionarily conserved kinetochore-associated
K[EIF]ED[AN]
Ndc8036
complex
EDAIY
Abl kinase substrate
involvedmotif
in chromosome segregation, spindle checkpoint activity and kinetochore clustering
protein_40_YER018C
Q..[QEH]E
Ndc8036
complex
[PSAT].[QE]E
LIG_TRAF2_1 involved in chromosome segregation, spindle checkpoint activity and kinetochore
transcription
clustering
regulator activity (0.001)
protein_40_YER012W
2 PRE1: Beta 4 subunit of the 20S proteasome; localizesL[GC][TM]P
the cell [ST]P
cycle
LIG_WW_4LIG_WW_4
Y
proteasome regulatory particle (sensu Eukaryota) (0.01)
protein_40_YDR510W
V..V[GEQ]
36 proteins; regulates chromatid cohesion, chromosome segregation,
Y
macromolecule
ring dynamics biosynthetic process (0.01)
protein_40_YDR477W
2 SNF1: AMP-activated serine/threonine protein kinase[DFY]D.E[EVF]
found in a complex containing
36Snf4pD.E
and members of the
Sec24pSec24pSec24p
Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
protein_40_YDR418W
[NGE]K.[KQ]KV
to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 cytosolic
ribosomal proteins
protein_40_YDR418W
A[RAG].[KYV]A
to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 cytosolic
ribosomal proteins
protein_40_YDR388W
2 RVS167: Actin-associated protein, subunit of a complex S[GTS]D
36 in regulation
S[ST] of actin cytoskeleton,
MDC1 BRCT
endocytosis,
domain and
binding
viability
motif
following starvation or osmotic stress; homolog of mammalian
actin
amphiphysin
cortical patch (1e-04)
protein_40_YDR303C
2 RSC3: Component of the RSC chromatin remodelingP[VQA].[LH]T
36 for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p
protein_40_YDR224C
[DES][PQ].AVS
36
assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
protein_40_YDR224C
[EDY]D.[THM]G
36 D..G
motif that function;
binds phosphate
Rad6p-Bre1p-Lge1p
in GDP and
mediated
GTP ubiquitination
binding proteins
regulates transcriptional activation, meiotic DSB formation and H3 methylation
protein_40_YDR174W
2 HMO1: Chromatin associated high mobility group (HMG)
KL..[LFT][RYP]T
36genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
protein_40_YDR099W
[KPR]A.[NCP]N
protein_40_YDR012W
2 RPL4B: Protein component of the large (60S) ribosomalR..[RAK]A
Rpl4Ap
R..K
and has similarity SH3
to E. coli
binding
L4 and
motif
rat L4
forribosomal
GADS SH3
proteins
recognizing slp-76 motif (nonconventional)
Y
protein_40_YDL213C
AP..[KLR][KEM]
36RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have
nucleolus
been yet identified
Y
protein_40_YDL147W
2 RPN5: Essential, non-ATPase regulatory subunit of the
A[APE].I[AS]L
36
protein_40_YDL055C
A[EAD].[ATF]G
guanyltransferase),
Y
Y
protein_40_YDL055C
G..V[TEK]
guanyltransferase),
36 synthesizes
D[DE].G..[VI][TS]
GDP-mannose
DNAfrom
polymerase
interaction motif in Cdc27
in cell wall biosynthesis; required for normal cell wallcytosol
structure(1e-05)
protein_40_YDL047W
2 SIT4: Type 2A-related serine-threonine phosphataseK[IG]..K[PHM]
36 of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
protein_40_YDL029W
2 ARP2: Essential component of the Arp2/3 complex, I[GHM]..[IPM]K
protein_40_YDL014W
[IVN]L.VD[ENA]
36 is required
LEVD for processing
Protease
of pre-18S
Caspase
rRNA; has
4-stringent
similarity to mammalian fibrillarin
protein_40_YCR009C
2 RVS161: Amphiphysin-like lipid raft protein; subunit[EGM]A.[EVQ]Q
of a complex (Rvs161p-Rvs167p)
36 that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
protein_40_YBR036C
2 CSG2: Endoplasmic reticulum membrane protein, required
II..[FTV][FYM]
36 D..SII.FF
and
CKfor
I delta
growth
kinase
at highphosphorylation
calcium concentrations
site (peptide screen)
protein_40_YBR017C
2 KAP104: Transportin, cytosolic karyopherin beta 2 involved
[EY]I..ES[KYM]
36 nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role in cell-cycle progression
protein_40_YBL092W
RV.[RAD][RN]
36L32 ribosomal protein; overexpression disrupts telomeric silencing
protein_40_YBL027W
[RGY]A.K[VGY]
to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while
cytosolic
the double
ribosome
null mutation
(sensu
is lethal
Eukaryota) (1e-19)
protein_40_YAL032C
DP..[VNT][EPW]
36 interacts
DP[FW]
LIG_AP2alpha_2
Prp22p and Prp46p; orthologous
Y to human transcriptional coactivator SKIP and can activate
spliceosome
transcription of
(1e-04)
a reporter gene
Y
protein_40_YAL032C
I.[DQW]T
nuclear
transcription
mRNA
of asplicing,
reporter gene
Y
oshea_punctate_composite
2 oshea_punctate_composite
[LVD]TF[LFN]I
36
[STA]FT[KQA]
36
nuclear membrane part (1e-18)
Y
oshea_Golgi_or_Golgi_to_vacuole
2 oshea_Golgi_or_Golgi_to_vacuole
L..[EFQ]I
36 L...I...[IL]
Corepressor nuclear box motif binds to nuclear receptors
Y
oshea_ER
2 oshea_ER
F[FLM].V[AVQ]
36
oshea_cytoplasm
2 oshea_cytoplasm
K..S[SEA]
36 K..[ST]
oshea_cytoplasm
2 oshea_cytoplasm
L.P[NEQ]
36 P.L.P
motif for interaction with MYND domain of BS69
[GIM]G.I[ALT]
36
oshea_bud
2 oshea_bud
R[ANK][SPV]S
36
Y
L[STE]P[SRW]K
36 [ST]P
LIG_WW_4LIG_WW_4
spindle (1e-10)
matsuyama_Cytosol
2 matsuyama_Cytosol
SK[HSD]
36 SKRKYRK
TP1 PATTERN
cell septum (1e-08)
Y
matsuyama_Cytoplasmic_dots 2 matsuyama_Cytoplasmic_dots
SS.[QLG][SQH]
36 S[ST]
cell septum (1e-13)
genetic_YPL055C
2 LGE1: Protein of unknown function; null mutant formsI[RL].LI[ECK]
36 R.L diploid null mutant
Cyclin
displays
A motif
delayed
that binds
premeiotic
cdk2DNA
complexes
Ysynthesis and reduced efficiency of meiotic nuclear division
genetic_YNL153C
S[EDQ]I
specifically
S[YILQP]II
BRCT domain
and transfers
of RAD9
targetbinding
proteinsmotif,
to it first Ser must be phosphorylated
cell cycle (1e-09)
genetic_YLR200W
2 YKE2: Subunit of the heterohexameric Gim/prefoldin[NSC]DF[SG]S
36folding
DF.DF
EF hand inand
gamma-synergin
actin
binding motif
Y
genetic_YLR200W
E..[NEG]N
cell cycle (1e-13)
genetic_YLR200W
S.[SLR]H
36folding
RSSLHL
Motif in beta-arrestin
and actin 2 for interaction with Jnk3
cell cycle (1e-14)
Y
genetic_YLR039C
2 RIC1: Protein involved in retrograde transport to the [VLN]T..L[EVY]
36 T..[IL]
with Rgp1p that actsFHA2
as a GTP
binding
exchange
motif,factor
Thr for
must
Ypt6p;
be phosphorylated
involved in transcription of rRNA and ribosomal protein genes
vesicle-mediated transport (0.001)
genetic_YLR039C
I..L[ITA]
36
Y
genetic_YLR039C
K.[LDG]E
36 G.[DN]F.K.DE
with Rgp1p that actsRUBISCO_LARGE
as a GTP exchange factor
PATTERN
for Ypt6p;Yinvolved in transcription of rRNA and ribosomal protein genes
genetic_YLR039C
S.E[YGK]
36 LSQE
with Rgp1p that actsATM
as a kinase
GTP exchange
substrate
factor
motif
for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
genetic_YEL003W
K.L[EPG]
specifically
LLKIL
AP-2 binding
and transfers
motif in
target
CXCR2
proteins
receptor
to it
genetic_YEL003W
T..[LKT]E
specifically
[ST]E
G protein-coupled
and transfersreceptor
target proteins
kinase
to 1
it substrate motif
Y
genetic_YDL020C
2 RPN4: Transcription factor that stimulates expression
K[SGD]..[LKP]Q
of proteasome genes; Rpn4p36
levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated
chromosome
by various
organization
stress responses
and biogenesis (sensu Eukaryota) (1e-04)
ucsf_loc_k_means_G6
6 Sub-cellular localization, 6 clusters
Q.Q[QEL]
36
Y
protein_40_YBR160W
A[YPD]..[TDQ]G
36
Kinesin
the CDK to specific
1.E-03
substrates 1.9
cytoskeleton organization and biogenesis (0.001)
protein_40_YBR160W
K[LIQ].D[FAY]G
35
Pkinase
the CDK to specific
1.E-18
substrates 5
protein_40_YDR224C
2 HTB1: One of two nearly identical (see HTB2) histoneG[GSR][KP]G
35 [ST]PG[ST]PGTP
CDK5 kinase
function;
substrate
Rad6p-Bre1p-Lge1p
motif
mediatedHistone
1.E-05
transcriptional
-2.4activation,
establishment
meiotic DSB formation
and/or maintenance
and H3 methylation
Y (1e-04)
yeast-207_GO-0003677
2 DNA binding
Q[QIN]Q
35
zf-C2H2
1.E-07
-1.7
DNA binding (1e-09)
yeast-462_GO-0019222
L.[SHN]L
35 L..L..L.L
Nuclear export signal
Zn_clus
1.E-07
-1.6
regulation of metabolism (10)
Y
protein_40_YMR125W
2 STO1: Large subunit of the nuclear mRNA cap-binding
[RTA]G..R[GY]
protein complex, interacts with
35 Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear
RRM_1
mRNA degradation
1.E-02
and telomere
-1.6
maintenance;
RNA binding
orthologous
(1e-06)
to mammalian CBP80
protein_40_YKR001C
[DRH][PIF]..PK
35 P.[ST]PKK.KK
organization, late
Cdc2
Golgi-retention
like protein
of kinase
some proteins,
substrate
regulating
motif peroxisome
HMG_box
biogenesis1.E-04
-1.6
chromatin remodeling (0.001)
yeast-631_GO-0050794
2 regulation of cellular process
H[TSD].E
35
zf-C2H2
1.E-11
-1.5
Y
yeast-630_GO-0051244
2 regulation of cellular physiological process
H[TSD].E
35
zf-C2H2
1.E-11
-1.5
Y
protein_40_YNL272C
[SET]T..Q[NKR]
Pkinase
1.E-12
-1.4
Y
yeast-1115_GO-0006996
S.T[KIN]
35 RS.[ST].P
14-3-3 binding motif (Ser must be phosphorylated)(eta)
WD40
1.E-04
-1.3
Y
protein_40_YCL059C
G[LIK]DI[PI]
DEAD
1.E-03
-1.2
nucleolus (1e-05)
protein_40_YPL043W
V[GWI]..[AHQ]R
and large
[AG]R
ribosomal subunit
Protease
biogenesis;
matriptase
constituent
protease
site
particles;
RNA recognition
-1.1
motifs (RRMs)
nucleolus (1e-05)
protein_40_YER102W
[ADT]A..LD[IQ]
DEAD
1.E-03
-1.1
nucleolus (0.01)
protein_40_YER102W
VAA[RTP][GK]
DEAD
1.E-03
-1.1
RNA helicase activity (0.01)
yeast-436_GO-0031323
H[TYV]G[ERV]K
35 G[KR][KR]
Amidation after cleavage after Gly (must bezf-C2H2
in secretory pathway)
1.E-12
-1
yeast-238_GO-0017111
I[FDT].[ASL]T
35
Helicase_C
1.E-05
-1
Y
protein_40_YNL002C
2 RLP7: Nucleolar protein with similarity to large ribosomal
[ANV]R..[DEW]I
35 [AG]R
of 66S pre-ribosomalProtease
particles; matriptase
plays an essential
protease
role in
site
processing of DEAD
1.E-02
ribosomal subunit
-1 RNAs
Y
yeast-752_GO-0016787
2 hydrolase activity
V[LVR]D[EIL]
35
Helicase_C
1.E-04
-0.9
Y
yeast-589_GO-0050896
N.N[STP]
35
Pkinase
1.E-03
-0.9
yeast-301_GO-0044451
2 nucleoplasm part
[KHQ]R.K[LER]
35 [KR]R
CLV_PCSK_KEX2_1
Bromodomain
1.E-02
-0.9
yeast-388_GO-0007275
2 development
[QKS]E[LAK]E
35 [ST]E
SH3_1
motif
1.E-02
-0.7
Y
protein_40_YOL133W
N.[GQF]E
conjugating enzyme
-0.7 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(1e-05)
of SCF
Y
protein_40_YML010W
2 SPT5: Protein that forms a complex with Spt4p and mediates
R.K[DEA]
35 [KR][LIM]K[DE]K[LIM]PG
DEHYDRIN_2
Spt4p-Spt5p
PATTERN
complex also plays
Y a role in DEAD
pre-mRNA processing
1.E-04
-0.7
yeast-661_GO-0050789
2 regulation of biological process
[RSV]P..[LKE]K
35 [ST]P
LIG_WW_4LIG_WW_4
Y
GATA
1.E-02
-0.6
protein_40_YOL133W
L[LKS]..[VPQ]D
35(SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation;
Y may tether Cdc34p
conjugating enzyme
-0.6 or E2)
cullin-RING
(a cullin) subunits
ligaseofcomplex
SCF
(1e-06)
protein_40_YOL133W
[NST]G[KAI]L
35(SCF);
G[SA]LNK
required for Gic2p,GDP-mannose
Far1p, Sic1p andbinding
Cln2p degradation;
motif in transporter
may tether Cdc34p
conjugating enzyme
-0.5 or E2)
macromolecule
and Cdc53p (a cullin)
catabolism
subunits of(1e-04)
SCF
Y
protein_40_YLR293C
I[RQ][LFK]T
IBN_N
1.E-03
Yrp4p, Yrb30p,
-0.5 Cse1p
protein
and Kap95p;
carrieryeast
activity
Gsp2p
(1e-05)
homolog
yeast-235_GO-0000278
L.Q[DSH]
35
HEAT
1.E-02
-0.4
Y
protein_40_YGL207W
2 SPT16: Subunit of the heterodimeric FACT complex[SPG]K.P[ATP]
35Polymerase
P[ST] II transcription
DNA
elongation
dependent
through
Protein
nucleosomes
kinase substrate
by destabilizing
motif
Pkinase
1.E-06
nucleosome
-0.4structure
yeast-752_GO-0016787
S..V[DNE]
35
Helicase_C
1.E-05
-0.3
protein_40_YER082C
2 UTP7: Nucleolar protein, component of the small subunitDL[EKV]
35 the
WDL
U3 snoRNA that isBinding
involvedmotif
in processing
for AP-2ofand
pre-18S
clathrin
rRNA
heavy chain
WD40
ear
1.E-04
-0.2
protein_40_YMR117C
L..Q[RVE]
Ndc8035
Y segregation,
SMC_N
spindle checkpoint
1.E-02
activity and0.1
kinetochore
chromosome
clustering
segregation (1e-04)
protein_40_YLR197W
D..[ESR]D
35 snoRNP
DDDD..S
complexes thatCasein
direct 2'-O-methylation
kinase 1 phosphorylation
of pre-rRNA during
motifits maturation;
WD40overexpression
1.E-03
causes spindle
0.1 orientation
nucleolus
defects(1e-33)
protein_40_YJL074C
2 SMC3: Subunit of the multiprotein cohesin complex K[TEV].A[VKL]
35 KTPAKEE
in mitotic cells; alsoGSK-3,
required,ERK1,
with Rec8p,
ERK2,
forCDK5
cohesion
substrate
and recombination
motifSMC_N
phylogenetically
0.2
conserved
cohesin
SMC chromosomal
complex (0.01)
Y
protein_40_YML069W
2 POB3: Subunit of the heterodimeric FACT complex (Spt16p-Pob3p),
[LP][AE]..AAR
which facilitates
35 RNA[AG]R
Pol II transcription Protease
elongation matriptase
through nucleosomes
proteasebysite
destabilizing and
Histone
then reassembling
1.E-04
nucleosome 0.4
structure;nuclear
interacts with
chromatin
DNA polymerase
(1e-04)alpha (Pol1p)
yeast-240_GO-0006807
2 nitrogen compound metabolism
VD.[LTK][YMF]
35 HAVDI
N-Cadherin ligand
Cys_Met_Meta_PP 1.E-02
0.5
Y
yeast-980_GO-0051179
2 localization
VL[LRP]
35 LRT
MFS_1
1.E-05
0.6
yeast-649_GO-0003676
L[NPR]K
35 G[SA]LNK
GDP-mannose binding motif in transporter RRM_1
1.E-06
0.6
protein_40_YNL272C
EI..[QAD][TIC]
Pkinase
1.E-07
0.6
Y
protein_40_YLR340W
KE..[AVD]A[LED]
35 shown
KEN
to be phosphorylated
LIG_APCC_KENbox_2
on serine 302
Y
Ribosomal_60s
1.E-02
0.6
protein_40_YIL019W
2 FAF1: Protein required for pre-rRNA processing andK[LKP]L[AKP]
35 KKKLPATGDYMNMSPVGD
Insulin receptor kinase substrate motif
WD40
1.E-02
0.6
oshea_bud_neck
2 oshea_bud_neck
I.[IRD]D
35
PH
1.E-03
0.6
Y
yeast-470_GO-0006259
2 DNA metabolism
I..[LVI]K
35
Y
BRCT
1.E-03
0.7
Y
yeast-251_GO-0005886
2 plasma membrane
V..[CIL]V
35
Y
MFS_1
1.E-03
0.7
protein_40_YKL065C
2 YET1: Endoplasmic reticulum transmembrane protein; may
F[AGF]..L
interact with ribosomes,
35based[FW]..L[FWY]
on co-purification experiments;
Regulatory homolog
motif in androgen
of human BAP31
receptors
protein Sugar_tr
1.E-03
0.9
oshea_bud_neck
2 oshea_bud_neck
P..R[FYW]
35 P.[PA]..R
SH3 binding for binding CIN85/SETA/Ruk SH3PH
domains (nonconventional)
1.E-03
0.9
Y
yeast-248_GO-0016072
2 rRNA metabolism
K.[LKA]A
35
DEAD
1.E-07
1
Y
yeast-215_GO-0005694
2 chromosome
L..E[ILMV]
35
Y
Histone
1.E-07
1
chromosome (1e-20)
yeast-1721_GO-0016043
T..[LEV]D
35 T..[IL]
WD40
1.E-04
1
protein_40_YPL153C
2 RAD53: Protein kinase, required for cell-cycle arrest in response
G[NFI]G
to DNA damage; 35
activated
G.G..G
Phosphate,when
FAD,
interacting
NADH, binding
motif
Septin
1.E-02with ARS11 and plays
DNA
a role
integrity
in initiation
checkpoint
of DNA replication
(0.001)
Y
protein_40_YOL012C
2 HTZ1: Histone variant H2AZ, exchanged for histone H2A
I[TE].P[AG]I
1.E-02
1
nuclear chromatin (0.01)
oshea_bud_neck
2 oshea_bud_neck
R.L[EKT]
35 R.L
Cyclin A motif that binds cdk2 complexes RhoGAP
1.E-04
1
Y
yeast-251_GO-0005886
2 plasma membrane
G..C
35
Sugar_tr
1.E-06
1.1
Y
protein_40_YER012W
LY..[NEA][PDL]
the cell cycle
Y
Proteasome
1.E-06
1.2
protein_40_YKR001C
IY[KP][VN]L
35 IY organization, late
cFGR
Golgi-retention
and Csk kinase
of some phosphorylation
proteins, regulatingsite
peroxisome
Histone
(peptidebiogenesis
screen) 1.E-02
1.3
N..P
35
Y
IBN_N
1.E-05
1.3
Y
protein_40_YAR019C
2 CDC15: Protein kinase of the Mitotic Exit Network that isR..[KPR]P
35 bodies
R..RPLPPLP.P
at late anaphase;SH3
promotes
binding
mitotic
motif
exitfor
byLyn
directly switching on thePkinase
1.E-22
1.5
Y
yeast-593_GO-0031981
2 nuclear lumen
A.[RGK]R
35 [KR]R
CLV_PCSK_KEX2_1
Helicase_C
1.E-04
1.6
Y
protein_40_YDL153C
KP...[LPF]
35for pre-18S
KP..[QK]
rRNa processing;
LIG_SH3_4LIG_SH3_4
essential nucleolar protein that, when
Y overproduced,
Pkinase
disrupts silencing
1.E-25
1.6
yeast-565_GO-0006464
L.[HIM]L
35 L..L..L.L
Nuclear export signal
Pkinase
1.E-11
1.7
protein_40_YER148W
K[RVA][LTV]K
35 to
KR
CLV_PCSK_PC1ET2_1
complex at promoters, essential for viability
Bromodomain
1.E-04
1.7
yeast-1036_GO-0005739
2 mitochondrion
[KPG]TR[LIC]Q
35
Mito_carr
1.E-18
2
mitochondrial envelope (1e-09)
yeast-281_GO-0016788
2 hydrolase activity, acting on ester bonds
[GK]NHE
35 [LIVMN][KR]GNHE
SER_THR_PHOSPHATASE PATTERN Metallophos
1.E-07
2.2
Y
protein_40_YJR002W
2 MPP10: Component of the SSU processome, whichD[KGF].V[KRT]
35
interacts with and controls the stability of Imp3p and Y
Imp4p, essential
WD40
1.E-05
to human Mpp10p
2.3
yeast-630_GO-0051244
2 regulation of cellular physiological process
H..[INT]I
35
Y
Cyclin
1.E-02
2.4
0.007
0.004
0.005
0.006
0.007
0.007
0.004
0.004
0.004
0.004
0.004
0.004
0.007
0.006
0.007
0.004
0.004
0.007
0.005
0.007
0.007
0.004
0.007
0.006
0.005
0.004
0.006
0.004
0.006
0.007
0.007
0.004
0.007
0.007
0.006
0.005
0.004
0.005
0.006
0.004
0.004
0.006
0.006
0.007
0.005
0.008
0.007
0.007
0.007
0.007
0.007
0.008
0.007
0.009
0.009
0.005
0.007
0.004
0.006
0.007
0.007
0.006
0.007
0.007
0.007
0.006
0.006
0.022
0.007
0.007
0.006
0.007
0.007
0.006
0.005
0.008
0.008
0.007
0.007
0.004
0.005
0.004
0.004
0.007
0.008
0.006
0.007
0.008
0.007
0.008
0.006
0.006
0.008
0.007
0.007
0.005
0.008
0.007
0.007
0.007
0.006
0.006
0.007
0.004
0.008
0.007
0.008
0.006
0.004
0.007
0.007
0.007
0.008
0.007
0.007
0.007
0.008
0.007
0.006
0.004
0.007
0.008
0.007
0.004
0.009
0.007
0.007
0.006
0.008
0.007
0.008
0.006
0.007
0.008
9
8
8
10
10
10
7
8
7
8
8
9
10
10
10
8
7
10
8
10
10
8
10
10
8
9
9
7
9
10
9
8
9
10
9
9
8
7
10
7
7
10
10
10
8
10
10
10
10
10
10
10
9
10
10
7
10
7
10
10
10
10
10
10
10
10
10
10
10
9
8
10
10
9
10
10
10
10
10
7
9
8
9
10
10
10
10
10
10
10
10
10
9
10
10
8
10
9
10
10
10
10
10
9
10
10
10
9
8
10
10
10
10
10
10
10
10
10
10
9
10
10
10
9
10
10
10
10
10
10
10
9
10
10
protein_40_YPL126W
yeast-631_GO-0050794
protein_40_YJR145C
protein_40_YLL008W
protein_40_YNL002C
yeast-335_GO-0016772
yeast-244_GO-0000279
protein_40_YGL111W
protein_40_YDR060W
yeast-299_GO-0005730
Oshea_mcl
yeast-335_GO-0016772
yeast-565_GO-0006464
yeast-706_GO-0043412
yeast-238_GO-0017111
yeast-1547_GO-0043283
yeast-207_GO-0003677
yeast-460_GO-0006351
yeast-856_GO-0009059
yeast-752_GO-0016787
yeast-661_GO-0050789
yeast-648_GO-0050791
yeast-648_GO-0050791
yeast-544_GO-0016070
yeast-462_GO-0019222
yeast-388_GO-0007275
yeast-341_GO-0045449
yeast-322_GO-0005654
yeast-248_GO-0016072
yeast-244_GO-0000279
yeast-244_GO-0000279
yeast-235_GO-0000278
yeast-233_GO-0006629
yeast-223_GO-0003735
yeast-216_GO-0006325
yeast-216_GO-0006323
yeast-215_GO-0005694
yeast-207_GO-0006974
yeast-1547_GO-0043283
protein_40_YPR182W
protein_40_YPR161C
protein_40_YPR120C
protein_40_YPR119W
protein_40_YPR080W
protein_40_YPR034W
protein_40_YPR034W
protein_40_YPL240C
protein_40_YPL204W
protein_40_YPL203W
protein_40_YPL146C
protein_40_YPL043W
protein_40_YPL031C
protein_40_YOR326W
protein_40_YOR310C
protein_40_YOR294W
protein_40_YOL127W
protein_40_YOL120C
protein_40_YOL013C
protein_40_YOL013C
protein_40_YNL301C
protein_40_YNL289W
protein_40_YNL209W
protein_40_YNL178W
protein_40_YNL124W
protein_40_YNL118C
protein_40_YNL031C
protein_40_YMR216C
protein_40_YMR125W
protein_40_YMR093W
protein_40_YML085C
protein_40_YML073C
protein_40_YML069W
protein_40_YML049C
protein_40_YML010W
protein_40_YLR448W
protein_40_YLR432W
protein_40_YLR432W
protein_40_YLR372W
protein_40_YLR197W
protein_40_YLR180W
protein_40_YLR180W
protein_40_YLR180W
protein_40_YLR175W
protein_40_YLR106C
protein_40_YKR001C
protein_40_YKL203C
protein_40_YKL172W
protein_40_YJR059W
protein_40_YJL203W
protein_40_YJL164C
protein_40_YJL106W
protein_40_YJL095W
protein_40_YJL092W
protein_40_YIL094C
protein_40_YIL061C
protein_40_YIL035C
protein_40_YHR196W
protein_40_YHR196W
protein_40_YHR169W
protein_40_YHR148W
protein_40_YHR141C
protein_40_YHR082C
protein_40_YHR079C
protein_40_YHR030C
protein_40_YHL001W
protein_40_YGR252W
protein_40_YGR218W
protein_40_YGR218W
protein_40_YGR218W
protein_40_YGR103W
protein_40_YGR074W
protein_40_YGL173C
protein_40_YGL076C
protein_40_YGL031C
protein_40_YER165W
protein_40_YER146W
protein_40_YDR477W
protein_40_YDR450W
protein_40_YDR449C
protein_40_YDR418W
protein_40_YDR394W
protein_40_YDR388W
protein_40_YDR388W
protein_40_YDR365C
protein_40_YDR303C
protein_40_YDR025W
protein_40_YDL213C
protein_40_YDL213C
protein_40_YDL213C
protein_40_YDL148C
protein_40_YDL148C
protein_40_YDL148C
protein_40_YDL055C
protein_40_YDL055C
2
2
2
2
2
2
2
2
2
2
13
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
NAN1: U3 snoRNP protein, component of the smallD[GKS].[VDT]K
35
containing U3 snoRNA; required for the biogenesis of18S rRNA
2.4
Y
0.007
2.5
0.008
Y
0.007
1.E-11
3.2
Y
0.006
R[EK][LIE]A
35 MR[DE][IL]
of 66S pre-ribosomalTUBULIN_B_AUTOREG
particles; plays an essentialPATTERN
role in processing of DEAD
1.E-03
ribosomal subunit
3.3 RNAs
0.007
VY[LKY][PAV]
groups
35 Y[LI]
3(phospho-peptide)
1.E-14
3.4
Y
(1e-32)0.007
M phase
L[SLN]Q
35 LSQE
MutS_III
1.E-05
3.5
M phase (1e-18)
0.008
L[FM]SA
35biogenesis
WLNS
Lipid binding motif in C-terminus of Apolipoprotein
DEADAII
1.E-05
3.5
nucleolus (1e-07)
Y
0.004
MAK21: Constituent of 66S pre-ribosomal particles, [REW]E[LDY]A
35 subunit
EDAIY
Abl kinase
in nuclear
substrate
export of
motif
pre-ribosomes; required DEAD
3.5 of cytoplasm
human CAATT-binding
organization
Y
0.007
nucleolus
[PTG][TSD]REL
35 RE..E
DEAD
1.E-13
3.8
0.006
Oshea_mcl
K[KPR].K
35 K[KR].[KR]
Zn_clus
1.E-07
4.1
0.035
I..[RQI]D
35
Pkinase
1.E-47
4.9
Y
(1e-12)0.007
[KNA]PE[NVR]
35
Pkinase
1.E-26
5.5
Y
0.007
D[LIK]KP
35 FKPY
TLA binding motif in Brinker transcription factor
Pkinase
for binding TLA
1.E-39
domain in Groucho
5.6
0.008
[RTI]V.[RLQ]T
35
Helicase_C
1.E-11
5.8
0.008
[IVD]H[RPN]D
35
Y
Pkinase
1.E-24
6
0.007
DNA binding
C..C[RGL]
35 C..C
Y
proteins
Zn_clus
1.E-15
13.8
DNA binding (1e-59)
0.008
[AMH]C..C[RIP]
35 C..C
Y
proteins
Zn_clus
1.E-19
16.9
0.008
A[ATG].K[AKT]
35
0.008
hydrolase activity
D[AEH]..[FCR]F
35
0.007
E[IGD]..T[FNH]
35
Y
0.007
E[IGD]..T[FNH]
35
Y
0.007
E[VKN]L[LEV]
35
0.008
RNA metabolism
[GKF]KVS[SY]
35 S[ST]
0.007
[DNP]AT[NLQ]
35
0.008
development
E[NMD].I[ENC]
35
0.007
[SLG]S.R[LPQ]E
35 S.R
PKC phosphorylation motif
0.008
nucleoplasm
[LVA]ENN[DMG]
35 KEN
LIG_APCC_KENbox_2
0.007
rRNA metabolism
R[KAE]..Q[KW]
35
0.008
M phase
[LEN]D.D[LVM]K
35 D.D
M phase (1e-15)
0.007
M phase
S[PQI].S[KMR]
35 SQ
M phase (1e-66)
0.008
mitotic cell cycle
SP.[NRH][DSK]
35 SP
Y
0.007
lipid metabolism
[AHF]F[IAC]Y
35 F[MLVI]Y
PTPRJ phosphatase substrate motif
0.008
LK[KDN]
35 F.F.LK...K.R
Phosphatidylserine binding motif in PKC
0.007
[AIF]I.Q[EG]L
35
DNA packaging
[AIF]I.Q[EG]L
35
chromosome
EL.K[LQI][LQG]
35 LLKIL
chromosome (1e-26)
0.008
R[IRV].[STM]R
35 [KR].R..[ST]
p70s6k phosphorylation site
Y
0.008
[YND]G..E[EIS]
35 Q[MLVI]DG..[DE]
CLV_TASPASE1
0.007
SMX3: Core Sm protein Sm F; part of heteroheptameric
[TF][ST].MDL
35 Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of humanU2-dependent
Sm F
spliceosome (1e-04)
0.004
SGV1: Cyclin (Bur2p)-dependent protein kinase that E[EIY][AER]E
35 EEEEYFELV
phosphorylates theEGFR
carboxy-terminal
kinase substrate
domain ofmotif
Rpo21p, which is the largest subunit of RNA polymerase II; regulated
nucleolus
by Cak1p(1e-10)
0.007
S[SKP]K[SKI]
to promote
S[ST]
initiation of DNAMDC1
synthesis;
BRCT
functions
domain
in formation
binding of
motif
mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.007
EY[LHI][EKQ]D
35the transition
Y[LI] from G2 to M
SH2
phase;
ligand
accumulates
for PLCgamma1
during G2 N-term.)group
andYM, then targeted
3(phospho-peptide)
via a destruction box motif for ubiquitin-mediated degradation by the proteasome
0.004
TEF1: Translational elongation factor EF-1 alpha; also
R[DTV]A[IPC]
encoded by TEF2; functions35
in the GR.A
binding reaction of aminoacyl-tRNA
Protease tPA proteolytic
(AA-tRNA) to
site
ribosomes
Y
0.006
[AYH]Q.Q[LFA]
Y
0.004
E[NAI]M[NLG]
0.005
[PKM]T.[DAY]E
35of Hsf1p;
YE docks with Tom70p
TPK-IIB/P38Syk
for mitochondrial
kinase
preprotein
phosphorylation
delivery; promotes
site (peptide
telomerase
screen)
DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
0.006
[QAR][LGQ]LDI
35 GTALL
Receptor recycling
segregation;
motif
binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
0.004
[SNA]Q.[EQD]S
35 in response
[ST]Q to nutrients ATM
via thekinase
Ras-cAMP
phosphorylation
signaling pathway;
site inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk3p
0.006
NOP53: Nucleolar protein; involved in biogenesis of the
S[PV]F[LM]D
60S subunit of the ribosome;
35 interacts
SP with rRNA processing
ERK1, factors
ERK2Cbf5p
Kinase
andsubstrate
Nop2p; null
motif
mutant is viable but growth is severely impaired
Y
0.004
[TSK]E..E[DEF]
and large
[ST]E
ribosomal subunit
G biogenesis;
protein-coupled
constituent
receptor
of 66Skinase
pre-ribosomal
1 substrate
particles;
motif
contains four RNA recognition motifs (RRMs)
0.007
F[KNH].[EC]D
35cellular response to nutrient levels and environmental conditions and progression through the cell cycle
0.005
MYO2: One of two type V myosin motors (along with D[IAE][ENF]V
35transport
SEDEE
of cargos; required
CKIIforkinase
the polarized
phosphorylation
delivery of secretory
site (peptide
vesicles,
screen)
the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle
Y
0.007
S[NGP]..L[KQP]I
35synthesis;
LLKILcomponent of AP-2
the small
binding
subunit
motif
processome
in CXCR2
complex,
receptor
which is required for processing of pre-18S rRNA
0.004
RRS1: Essential protein that binds ribosomal protein
[SEA]K..[KTY]K
35exportK..[ST]
of the 60S pre-ribosomal
PKA kinase
subunitsubstrate
during ribosome
motif biogenesis;
Y
mouse homolog shows altered expression in Huntington's
nucleolus
disease
(1e-12)
model mice
0.007
RA.[KRA][VAE]
35 subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal cytosolic
motif
0.007
R..A[GRF]
35 and has similarity to rat L18 ribosomal protein; intron of RPL18A
Y pre-mRNA forms stem-loop structures that are a target
cytosolic
for Rnt1p large
cleavage
ribosomal
leading to subunit
degradation
0.007
HRD1: Ubiquitin-protein ligase required for endoplasmicE.A[EVW]
35
(ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association
amino
withacid
Hrd3p;
and
contains
derivative
an H2 ring
metabolism
finger
(0.01)
0.007
LL[LWD][YV]L
35 LLDLL
(ERAD) of misfolded
Clathrin
proteins;
binding
genetically
motif
linked
in AP1
to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger
0.004
AR..[AR]
35 and
AR..R[RK]RSFRR
PKC
L18 eta
ribosomal
kinase
protein
substrate motif
Y
0.007
PCL1: Pho85 cyclin of the Pcl1,2-like subfamily, involved
E[NLP][ESA]N
35cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
Y
0.006
SSB2: Cytoplasmic ATPase that is a ribosome-associated
[SNL][SE].FGS
35 LFG
with J-protein partner
Protease
Zuo1p; may
Papain
be involved
substrate,
in the
a folding
prototype
of newly-synthesized
cysteine proteinase
polypeptide chains; member of the HSP70 family; homolog of SSB1
0.004
R[VAT].[GRQ]G
35
0.007
[GQP]G.[RMT]G
processing,
GGRGG
forms a complex
Arginine
with Shq1p
methyl
andtransferease
interacts with H/ACA
substrate
snoRNP
motifcomponents
(PRMT1) Nhp2p and Cbf5p; has similarity ribonucleoprotein
to Gar1p and other RNA-binding
complexproteins
(1e-07)
0.006
DI..[LR][EHW]
35
Y
0.005
HHT2: One of two identical histone H3 proteins (see [NPE]P..E[LIP]
35 for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation,
chromatinand
modification
mitotic phosphorylation
(1e-05)
0.006
SKY1: SR protein kinase (SRPK) involved in regulating
[RGF]R.[GWA]R
metabolism
[AG]R
and cation homeostasis;
Protease similar
matriptase
to human
protease
SRPK1site
ATP-dependent helicase activity (0.001)
0.005
STO1: Large subunit of the nuclear mRNA cap-binding
AD.[KWY][RWM]
35 Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
0.004
[IKF]E..[EIL]G
0.007
I[KTV]..G[VMN]
Y
0.007
RA[AGP][RKS]
35 has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
Y
0.007
POB3: Subunit of the heterodimeric FACT complexD[EYH]..D[ECN]
35 RNAD..D...D
Pol II transcription Protein
elongation
phosphatase
through nucleosomes
1 binding
by motif
destabilizing
Y
and then reassembling nucleosome structure;RNA
interacts
elongation
with DNA polymerase
from RNAalpha
polymerase
(Pol1p)
II promoter (1e-18)
0.007
RSE1: Protein involved in pre-mRNA splicing; component
[YWV]D..[IQW]K
of the pre-spliceosome; 35
associates with U2 snRNA; involved in ER to Golgi transport
RNA splicing (1e-15)
0.006
SPT5: Protein that forms a complex with Spt4p and [LEV]L..K[LHP]
35
Y
0.007
K..[AKW]A
35
Y
0.006
K[KPD][RQS]K
35
member of a four-gene family in S. cerevisiae, constitutively
Y
expressed
rRNA metabolism (0.01)
0.006
NL[NA][ETR]E
35 [ST]E
G protein-coupled
family in S. cerevisiae,
receptorconstitutively
kinase 1 substrate
expressed
motif
0.004
SUR4: Elongase, involved in fatty acid and sphingolipid[IF]TL[IMC]
very long
T[LF]CGT
chain 20-26-carbon
PDK1
fatty phosphorylation
acids from C18-CoA
site
primers;
on AGC
involved
kinase
in regulation
activationof loop
sphingolipid biosynthesis
0.006
[KSD]T.LL[NAK]
35 snoRNP
DLLcomplexes thatBinding
motif for clathrin
of pre-rRNA
heavy chain
during ear
its maturation; overexpression causes spindle orientation
nucleolus
defects(0.001)
0.005
SAM1: S-adenosylmethionine synthetase, catalyzes [PV]L..[EAQ]L
of ATPL..LL
Motif
methionine;
for interaction
one of two
with
differentially
nuclear receptors,
regulated isozymes
docking(Sam1p
motif for
andp300
Sam2p)
on p53 to promote
carboxylic
acetylation
acid metabolism (0.001)
0.007
G..T[IEN]
Y
0.007
VL[RAV]
of ATPLRT
LKB1
methionine;
Kinaseone
substrate
motif
Yregulated isozymes (Sam1p and Sam2p)
cytosol (0.001)
Y
0.006
CBF5: Pseudouridine synthase catalytic subunit of box
A[KDE][RKG]D
H/ACA small nucleolar ribonucleoprotein
35
particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2
0.007
MDN1: Huge dynein-related AAA-type ATPase (midasin),
[IDM]E.[LMQ]A
particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p), may mediate Y
ATP-dependent remodeling of 60S subunits and subsequent
ribosome
export from
assembly
nucleoplasm
(0.001)
to cytoplasm
Y
0.006
VPS1: Dynamin-like GTPase required for vacuolar sorting;
[SHQ]Q.S[MPI]
35 [ST]Q
organization, late
ATM
Golgi-retention
of some proteins,
site
regulating peroxisome biogenesis
0.006
TOR2: PIK-related protein kinase and rapamycin target;L.L[MAW]
35 thatDALDL
regulates growth in14-3-3
response
binding
to nutrients
motif and
in ExoS
TORC2, a complex that regulates cell-cycle dependent polarization plasma
involved in meiosis
Y
0.006
EBP2: Essential protein required for the maturation D[DVW]E[EGM]
of 25S rRNA and 60S ribosomal
35subunit
SD.E
assembly, localizes
Casein
to the kinase
nucleolus;
II substrate
constituentmotif
of 66S pre-ribosomal particles
Y
0.007
PTK2: Putative serine/threonine protein kinase involved
EK..[SEV][RAY]S
35across
K..[ST]
plasma membrane;
PKA
enhances
kinasespermine
substrate
uptake
motif
0.005
PRP21: Subunit of the SF3a splicing factor complex, [TIH]PL[LP]E
small nuclear ribonucleoprotein complex (1e-05)
0.004
TPK1: cAMP-dependent protein kinase catalytic subunit; promotes
Q..P vegetative growth
35 in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP;
phosphotransferase
partially redundant with
activity,
Tpk2p alcohol
and Tpk3pgroup as acceptor (0.01)
0.006
[QER]P.[PHA]H
with Ime1p
P.P and mediates its
motif
stability,
in interleukin
activates Ndt80p;
5 receptor
IME2necessary
expression is
forpositively
signaling
regulated by Ime1p
0.004
[LI]L.V[LCP]G
0.004
E.[ETQ]N
for proper
Y.E.E
Src phosphorylation
site and transition from Meiosis I to II; affects genome stability by suppressing
DNA metabolism
unscheduled(1e-05)
homologous recombination
0.007
[AEW]T.[EID]G
Y
0.006
SNP1: Component of U1 snRNP required for mRNAR[SPF][RQV]D
interact
YRSVDE
Branched
to regulate
chainpolyadenylation;
alpha-ketoacidhomolog
dehydrogenase
of human U1
kinase
70K protein
substrate motif
0.006
CKA1: Alpha catalytic subunit of casein kinase 2, a K[KPF]KS[KQV]
35in cellKKKKKK[ST]
TGF beta
the holoenzyme
receptor kinase
also contains
substrate
CKA2,
motif
CKB1 and CKB2, the many substrates include transcription
nuclearfactors
lumen
and(0.01)
all RNA polymerases
Y
0.006
A.[GFK]K
35 the
VPGKARKKSSCQLL
U3 snoRNA that isCalmodulin-dependent
involved in processing of protein
pre-18S kinase
rRNA IV substrate motif
nucleolus (1e-21)
0.007
E[KIM][KVL]D
Y
0.007
DBP8: Putative ATP-dependent RNA helicase of the DEAD-box
E..A[AFK]
family involved in 35
biogenesis of the 40S ribosomal subunit
cytosol (1e-05)
0.006
IMP3: Component of the SSU processome, which is [LE]K..G[LN]T
35
essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA processing of 20S pre-rRNA (1e-04)
0.004
S.L[STF]
35 and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
0.006
KSP1: Nonessential putative serine/threonine protein kinase
N.E[GYC]
of unknown cellular role;
35 overproduction causes allele-specific suppression of the prp20-10 mutation
0.006
PA[SEH][PRS]
mediates
APAP
the unfolded protein
Motif
response
for hydroxylation
(UPR) by regulating
of Pro residues,
Hac1p synthesis
whichthrough
can further
HAC1be
mRNA
modified
splicing;
with
Kar2p
arabinogalactan
binds inactive Ire1p and releases from it upon ER stress
0.007
E[GQW]..D[ASY]
wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
0.006
S..[SNL]S
to Rpl14Ap
S..[ST]
and has similarity
Casein
to rat L14
Kinase
ribosomal
I consensus
protein phosphorylation site (N-term Ser must first be phosphorylated)
0.007
EL..[LQG]L[GIA]
35 H3; L..LL
Motif
ADA
forand
interaction
SAGA histone
withacetyltransferase
nuclear receptors,
complexes;
docking
founding
motif for
member
p300 of
onthe
p53
Gcn5p-related
to promoteN-acetyltransferase
acetylation
superfamily
0.004
[LIN]A[AGV]L
35 from the nucleus
Y
0.007
[SKT]T[PMC]A
35 from
KTPAKEE
the nucleus
GSK-3, ERK1, ERK2, CDK5 substrate
Y
motif
0.007
GS[TDM][GHR]
35 from
KSGST
the nucleus
eIF4 motif phosphorylation motif
protein import into nucleus (1e-05)
0.007
[KGV]KK[KAV]
35 KKKKKK[ST]
TGF beta
different
receptor
pre-ribosomal
kinaseparticles;
substrate
Y required
motif for exit from G0 and the initiation ofcytoplasm
cell proliferation
Y
0.007
SMD1: Core Sm protein Sm D1; part of heteroheptameric
[DIE]GQ[LRT]
35 GGQ
Smd3p, Sme1p, Smx3p,
N-methylation
and Smx2p)motif
that isinpart
E. coli,
of theGln
spliceosomal
residue inU1,
methylated,
U2, U4, andmimics
U5 snRNPs;
CCAhomolog
motif atofthe
human
end
nuclear
Sm
of tRNA
D1mRNA
molecule
splicing, via spliceosome (1e-14)
0.006
QQ[PAH][SYM]
35 (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomalcytoplasmic
RNA maturation,
mRNA
and telomere
processing
maintenance
body (1e-05)
0.005
RPL7A: Protein component of the large (60S) ribosomalK..[KAR]A
Rpl7Bp
K[KR].[KR]
and has similarity Nuclear
to E. coli L30
localization
and rat L7motif
ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding
cytosolic
Domain (NDB2)
0.006
RPL24A: Ribosomal protein L30 of the large (60S) ribosomal
RA.[KRG][VGT]
cytosolicrate
0.006
[LF]F[GF]AK
complex, mediates
35 interactions
GAKRH
between theHISTONE_H4
5' cap structure PATTERN
and the 3' mRNA poly(A)
Y tail, involved in control of poly(A) tail length, interactssnRNP
with translation
protein
factor
import
eIF-4G
into nucleus (0.01)
0.004
[LWV]S..[GAK]Y
possiblyxinvolved
U5 tri-snRNP
in processing
complex
tRNA, snoRNA,
(1e-04)and rRNA
0.006
SNF1: AMP-activated serine/threonine protein kinase found
TP[EFK]
35Snf4pLTP
and members of the
RAF1
Sip1p/Sip2p/Gal83p
kinase substrate
family;
motif
required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
0.006
[KRD][EA]YQ
to Rps18Bp
[DE]Y
and has similarity
EGFR
to E.kinase
coli S13substrate
and rat S18
motif
ribosomal proteins
0.004
[LIS]TSK[LAD]
0.004
S.L[STQ]
to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
0.007
[IMC]D[QPI]Y
35 IY
in the degradation ofcFGR
ubiquitinated
and Csk
substrates;
substrate of N-acetyltransferase
site (peptideBscreen)
0.004
[IF]..AK
involved
35 in regulation
GAKRHof actin cytoskeleton,
HISTONE_H4
endocytosis,
PATTERN
and viability following starvation or osmotic stress; homolog of mammalian
bipolar
amphiphysin
bud site selection (1e-05)
0.007
RVS167: Actin-associated protein, subunit of a complex S[NVG]K
35 in regulation
RRK.S.KR
PKCgamma
endocytosis,
and viability following
site starvation
(peptide or
screen)
osmotic stress; homolog of mammalian
bipolar
amphiphysin
bud site selection (1e-05)
0.006
ESF1: Nucleolar protein involved in pre-rRNA processing;
K..[KNQ]K
35decreased
P.[ST]PKK.KK
18S rRNA levels
Cdc2 like protein kinase substrate motif
nucleolus (1e-14)
Y
0.006
[LDK][LCG].EC
35 for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar
RSCtocomplex
Rsc30p (1e-05)
0.004
[GRE]AA[KRS]
translation (1e-11)
Y
0.007
E[AEK]..[GEA]S
nucleolus
been yet identified
Y
0.007
EG.[ESR][EAN]
35RNAIEGR
Protease
and has
Protease
similarityFactor
to hydrophilins;
Xa
NOP6 may be a fungal-specific gene as no homologs have
nucleolus
been yet identified
0.007
F[LTV]..LE[SDK]
35RNAF..LL
A nuclear
and has
receptor
similaritybox
to hydrophilins;
in the FF domain
NOP6 may
which
be abinds
fungal-specific
nuclear receptors
gene as no and
homologs
are components
have
ribosome
been yetofbiogenesis
identified
transcriptional
in higher
(0.01)
coactivators
eukaryotes
Y
0.004
[ST]L[DHP]AT
35 nuclear
PLTLP
RAF1 kinase
subunits;
substrate
also present
motifin the small subunit processome complex, which is required for snoRNA
processing binding
of pre-18S(1e-07)
rRNA
0.004
DE[ESR][DFK]
35 nuclear
SEDEE
CKII kinase
subunits;
phosphorylation
also present insite
the (peptide
small subunit
screen)
processome complex, which is required for nucleolus
processing of(1e-21)
pre-18S rRNA
0.007
LSV[VKI][SNK]
35 nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for small
processing
nucleolar
of pre-18S
ribonucleoprotein
rRNA
complex (1e-05)
0.004
[TGP]K..L[EAM]
guanyltransferase),
Y
0.007
V.[VGY]E
guanyltransferase),
35 synthesizes
YE
GDP-mannose
TPK-IIB/P38Syk
from GTP and kinase
mannose-1-phosphate
phosphorylation
in cell
site
wall
(peptide
biosynthesis;
screen)
required for normal cell wallATPase
structure activity (0.01)
Y
0.007
H..[INT]I
35
Y
WD40
Cyclin
1.E-08
1.E-02
R..[AKR]A
20S pre-rRNA
R..K processing; identical
SH3 binding
to Rps4Bp
motifand
forhas
GADS
similarity
SH3torecognizing
rat S4 Helicase_C
ribosomal
slp-76
protein
motif (nonconventional)
1.E-03
2.9
[TIS]DF[GRY]
including
DF.DF
EF hand subunits;
in gamma-synergin
constituent of binding
66S pre-ribosomal
motif Pkinase
particles
10
10
10
10
10
10
9
8
9
10
10
10
9
10
10
10
10
10
10
10
10
10
10
10
10
10
10
9
10
9
10
10
9
10
9
9
10
10
10
7
10
10
9
9
8
9
10
9
10
9
10
9
10
8
10
10
10
10
8
10
10
8
9
10
8
10
9
7
10
10
10
10
9
10
10
10
7
10
8
10
9
10
10
9
8
10
10
9
7
10
8
7
10
10
10
9
10
10
10
7
10
10
10
10
10
8
10
10
10
10
10
8
10
10
7
10
10
9
8
10
9
10
10
9
7
10
10
10
8
8
10
8
10
10
protein_40_YDL029W
protein_40_YDL015C
protein_40_YCR057C
protein_40_YBR154C
protein_40_YBR109C
protein_40_YBR009C
protein_40_YBL003C
protein_40_YBL003C
protein_40_YBL002W
protein_40_YAL032C
protein_40_YAL032C
oshea_bud_neck
oshea_ambiguous
matsuyama_periphery
matsuyama_ER
genetic_YLR200W
genetic_YLR200W
genetic_YLR039C
genetic_YGL058W
genetic_YGL058W
genetic_YER083C
genetic_YER083C
genetic_YAL024C
protein_40_YBL002W
yeast-207_GO-0006974
protein_40_YLL045C
yeast-544_GO-0016070
yeast-436_GO-0031323
yeast-460_GO-0006351
protein_40_YHR196W
protein_40_YKL014C
protein_40_YIL019W
yeast-462_GO-0019222
yeast-222_GO-0009308
protein_40_YML010W
oshea_bud_neck
yeast-460_GO-0006351
yeast-460_GO-0006351
protein_40_YOL133W
matsuyama_nucleolus
protein_40_YNL175C
yeast-1166_GO-0005488
protein_40_YOL133W
protein_40_YLR293C
yeast-216_GO-0006325
yeast-216_GO-0006323
protein_40_YJR002W
protein_40_YGR090W
protein_40_YDL031W
yeast-238_GO-0017111
protein_40_YOL133W
protein_40_YJL130C
protein_40_YHR196W
protein_40_YOR310C
protein_40_YML010W
yeast-631_GO-0050794
yeast-630_GO-0051244
yeast-301_GO-0044451
yeast-256_GO-0016462
protein_40_YKL101W
yeast-388_GO-0007275
protein_40_YJL074C
protein_40_YJL074C
protein_40_YER082C
yeast-630_GO-0051244
yeast-462_GO-0019222
protein_40_YPL240C
protein_40_YLR340W
protein_40_YLR293C
protein_40_YLR276C
yeast-1166_GO-0005488
protein_40_YDR388W
protein_40_YOL018C
yeast-752_GO-0016787
yeast-256_GO-0016462
protein_40_YER012W
yeast-589_GO-0050896
protein_40_YLR293C
yeast-437_GO-0044429
yeast-274_GO-0005840
protein_40_YFR052W
yeast-752_GO-0016787
yeast-256_GO-0016462
yeast-980_GO-0051179
protein_40_YNL272C
protein_40_YHR148W
yeast-1939_GO-0003824
protein_40_YNL186W
protein_40_YPL093W
protein_40_YML007W
yeast-376_GO-0019219
protein_40_YMR093W
yeast-593_GO-0031981
yeast-1974_GO-0005634
yeast-1340_GO-0044267
yeast-565_GO-0006464
protein_40_YAR019C
protein_40_YGL245W
yeast-1389_GO-0044260
yeast-345_GO-0006396
protein_40_YER006W
yeast-565_GO-0006464
yeast-631_GO-0050794
yeast-630_GO-0051244
protein_40_YJR066W
protein_40_YJR066W
yeast-792_GO-0006412
yeast-589_GO-0050896
yeast-548_GO-0051641
yeast-548_GO-0051641
yeast-470_GO-0006259
yeast-437_GO-0044429
yeast-336_GO-0005783
yeast-295_GO-0016192
yeast-285_GO-0012505
yeast-284_GO-0005740
yeast-262_GO-0031224
yeast-256_GO-0016021
yeast-251_GO-0005886
yeast-248_GO-0031966
yeast-235_GO-0000278
yeast-212_GO-0045045
yeast-205_GO-0005856
yeast-1115_GO-0006996
yeast-1036_GO-0005739
protein_40_YPR120C
protein_40_YPL240C
protein_40_YPL240C
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
ARP2: Essential component of the Arp2/3 complex, [HMA]R.I[KAY]
35 nucleation
[AG]Rcenter required
Protease
for the motility
matriptase
and integrity
protease
of actin
sitepatches; involved in endocytosis and membrane growth and polarity
0.005
9
0.006
10
0.007
10
0.005
10
CMD1: Calmodulin; Ca++ binding protein that regulates
[GIQ][ID]DLG
Ca++ independent processes
35 (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
0.004
7
HHF1: One of two identical histone H4 proteins (see[IWP]L..[FQY]E
35 forYE
chromatin assembly
TPK-IIB/P38Syk
and chromosomekinase
function;phosphorylation
contributes to telomeric
site (peptide
silencing;screen)
N-terminal domain involved in maintaining genomic integrity
Y
0.007
10
ED.[SAT][LAQ]
35 required
YEDPfor chromatinFyn
assembly
SH2 and
domain
chromosome
binding function;
motif DNA damage-dependent phosphorylation by Mec1p facilitates
establishment
DNA repair; acetylated
and/or maintenance
by Nat4p
Y (0.001) 0.007
10
R[KFH]R
35 required
HHH[RK]SPR[RK]R
for chromatinCdc2
assembly
kinase
and substrate
chromosome
motif
function; DNA damage-dependent phosphorylation by Mec1p facilitates
establishment
DNA repair; acetylated
and/or maintenance
by Nat4p
of chromatin architecture (1e-10) 0.006
9
DE[ELA][ERV]
35 SEDEE
CKII kinase
function;
phosphorylation
Rad6p-Bre1p-Lge1p
site (peptide
mediated
screen)
ubiquitination regulates transcriptional activation,
nucleoplasm
meiotic DSB(0.001)
formation and H3 methylation
Y
0.007
10
E..[LSA]N
nuclear
transcription
mRNA
of asplicing,
reporter gene
Y
0.007
10
I.[AGS]K
nuclear
transcription
mRNA
of asplicing,
reporter gene
Y
0.006
9
PI[SMA]S[TE]
35 S[ST]
0.004
7
N..N[TLN]
35
Y
Y
0.007
10
oshea_bud_neck
[IEW]LM[NKY]
35 LFDLM
Y
0.007
10
oshea_ambiguous
S[FNV].QL[EQD]
35
Y
receptor activity (0.01)
0.006
10
L[QDL]..[KRV]E
35
spindle (1e-67)
Y
0.009
10
P.N[ALH]
35
spindle (1e-92)
Y
0.009
10
Q..L[KVR]
35
spindle (1e-12)
0.009
10
matsuyama_periphery
[FAW]F..L[FTN]
35 F..LF
0.009
10
matsuyama_ER
K.[KLI]R
35 [KR]R
CLV_PCSK_KEX2_1
0.009
10
YKE2: Subunit of the heterohexameric Gim/prefoldin[KLR]E..L[TPD]
Y
0.006
9
[RYQ]TI[KRE]
establishment of organelle localization (0.001)
0.007
10
RIC1: Protein involved in retrograde transport to the cis-Golgi
TE.[QIK][KSF]
35 [ST]E
with Rgp1p that actsGasprotein-coupled
a GTP exchange receptor
factor for Ypt6p;
kinaseinvolved
1 substrate
in transcription
motif of rRNA and ribosomal protein genes
0.006
10
D[LEV]L repair (with Rad18p),
35 DLL
Binding
silencing,
motif
and
forubiquitin-mediated
clathrin heavy chain
N-end ear
rule protein degradation (with Ubr1p)
Y
0.007
10
I..[LYA]K repair (with Rad18p),
35
0.006
10
GET2: Subunit of the GET complex; required for meiotic
[AQ]E[SGE]S
35retrieval
[ED]GSG[DE]
of HDEL proteinsGlycosaminoglycan
from the Golgi to the ER
attachment
in an ERD2site
dependent fashion; may be involved in cell wall function telomere organization and biogenesis (0.01)
0.006
10
GET2: Subunit of the GET complex; required for meiotic
[NFP]L[KFD]D
35retrieval
LFDLM
of HDEL proteinsBinding
from the motif
Golgi to
in the
Clint
ERfor
in an
clathrin
ERD2TD
dependent
domainfashion; may be involved in cell wall function Golgi apparatus part (1e-04)
0.007
10
E..T[LEI]
mitotic
with
cell
Ras2p-GTP
cycle (1e-11)
0.007
10
G[GSM]K[GWH]
34
1.E-07
transcriptional
-2.8activation,
chromatin
meiotic DSB
assembly
formation
orand
disassembly
H3 methylation
(1e-04)
Y
0.006
8
I[SRC]..[EDI]S
34
SMC_N
1.E-02
-2.3
0.007
10
A.[GAI]K
to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased
Brix
amounts1.E-02
-2.2
0.006
10
RNA metabolism
[HIK]..GR
34 [AG]R
DEAD
1.E-10
-2
0.007
10
L.S[LKQ]
34 WLNS
Lipid binding motif in C-terminusYof Apolipoprotein
Zn_clus
AII
1.E-10
-1.6
0.007
10
L..P[SN]
34 P[ST]
zf-C2H2
1.E-05
-1.4
0.007
10
R[RLE]K[EQY]
WD40
1.E-03
-1.4
nucleolus (1e-16)
0.007
10
DV[AH][AS]R
34 associated
Protease
pre-ribosomal
matriptase
particle;
protease
proposed
siteto be involved
DEAD
-1.3 subunit
0.004
8
FAF1: Protein required for pre-rRNA processing and 40S
[DMV]E[ES]D
ribosomal subunit assembly
34 EED
Ankyrin B C-terminal motif that binds internalWD40
-1.3
Y
0.007
10
H[TS].E[KRN]P
34
zf-C2H2
1.E-20
-1.2
0.008 (1e-14)
10
amine metabolism
L..[KGD]A
34
tRNA-synt_2b
1.E-03
-1.2
Y
0.007
10
[RP]T.R[KGR]
34
pre-mRNA processing
1.E-03
-1.2
nuclear lumen (0.001)
0.007
10
oshea_bud_neck
E[HLF]S
34 R[RH][RH][RE]RE[RH]SR[RD]L
CLK2 kinase substrate motif
RhoGAP
1.E-03
-1.2
bud (1e-59)
Y
0.007
10
K.[DKR]S
34 [NT]K.D
Zn_clus
1.E-06
-1.1
0.007
10
LP[PDK]
34 LPDEL
Motif in CBP for interaction with PPARg-LBD
Zn_clus
-1.1
0.007
10
I.[NDV]N
conjugating enzyme
-1.1 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(1e-08)
of SCF
Y
0.006
10
matsuyama_nucleolus
T[GN][SMF]GK
34 [SAG]GGTG[SA]G
TUBULIN PATTERN
Helicase_C
1.E-14
-1.1
0.008
9
E[EKA]..[KSL]D
1.E-02of pre-18S-1rRNA ribosome biogenesis (1e-13)
0.007
10
binding
S..[QTN]E
34 S..[ST]
Casein Kinase I consensus phosphorylationRRM_1
must first be -0.8
phosphorylated)
0.007
10
[FKC]D.L
34(SCF);
DLL
required for Gic2p,Binding
Far1p, Sic1p
motifand
for Cln2p
clathrin
degradation;
heavy chain
mayear
tether Cdc34p
conjugating enzyme
-0.8 or E2)
protein
and Cdc53p
catabolism
(a cullin)(1e-07)
subunits of SCF
Y
0.007
10
D..E[TAW]
IBN_N
1.E-11
Yrp4p, Yrb30p,
-0.8 Cse1p
nuclear
and Kap95p;
transport
yeast(1e-18)
Gsp2p homolog
Y
0.006
9
[SFG]N.[NPE]N
34
-0.7
9
DNA packaging
[SFG]N.[NPE]N
34
-0.7
9
MPP10: Component of the SSU processome, which[DHM]E[ESK]D
34 E[ST]D
interacts with and
Ankyrin
controls
Gthe
binding
stability
motif
of Imp3p
in KNCQ2
and Imp4p,
and essential
KNCQ3
WD40
for
potaqssium
viability; similar
channels
1.E-04
to human Mpp10p
-0.7
nucleolus (1e-24)
0.007
10
K[KHP].[SNF]G
34on computational analysis of large-scale protein-protein interaction
Y dataHelicase_C
1.E-02
-0.7
Y
0.007
10
T[GEH][SK]GK
34 [SAG]GGTG[SA]G
TUBULIN
particles;PATTERN
essential protein involved in ribosome
Helicase_C
biogenesis
1.E-04
-0.7
0.004
8
I[NML].I[DGQ]
34
ABC_tran
1.E-06
-0.6
0.008
10
I[DSI]L
34 YIDL
SH2 ligand for Syp (also tyr is phosphorylated
HEAT
by the insulin receptor)
1.E-05
-0.6
ATP binding (0.001)
0.008
10
[IVQ]D[APR]L
34(SCF);
DALDL
required for Gic2p,14-3-3
Far1p, binding
Sic1p and
motif
Cln2p
in degradation;
ExoS
may tether Cdc34p
conjugating enzyme
-0.5 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(0.001)
of SCF
0.007
10
URA2: Bifunctional carbamoylphosphate synthetase I[DLC].[EHC]E
34
(ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis
IBN_N of pyrimidines;
1.E-03
both activities
-0.5are subject
protein
to feedback
carrier activity
inhibition (1e-05)
by UTP
0.006
10
F[TNQ].K[YEF]
WD40
1.E-02
-0.4
0.006
9
NOP58: Protein involved in pre-rRNA processing, 18S rRNA
K..K[RLV]
34synthesis;
KR component of CLV_PCSK_PC1ET2_1
the small subunit processome complex,
Y which is required
WD40for processing
1.E-04
of pre-18S rRNA
-0.2
nucleolus (1e-46)
0.007
10
G..[GPM]R
34 [AG]R
Protease
Spt4p-Spt5p
matriptasecomplex
protease
alsosite
plays
Y a role in DEAD
pre-mRNA processing
1.E-03
-0.2
0.006
10
I..[LPI]K
34
Zn_clus
1.E-05
-0.1
0.007
10
I..[LPI]K
34
Zn_clus
1.E-05
-0.1
0.007
9
nucleoplasm part
KR[KRE]
34 KR
CLV_PCSK_PC1ET2_1
Bromodomain
1.E-04
-0.1
0.007
10
[TDG]I[GKD]V
34
Ras
1.E-04
0
Y
0.008
10
HSL1: Nim1p-related protein kinase that regulates the
E[NQ]..K[KAI]
morphogenesis and septin checkpoints;
34
associates with the assembled septin filament; required along with
DnaJ_C
Hsl7p for bud neck
1.E-03
recruitment, phosphorylation,
0.1
and degradation of Swe1p
0.007
9
development
E..T[DPS]
34
Y
SH3_1
1.E-02
0.2
Y
0.007
10
D[AFR][GAN]L
34
in mitotic cells; also required, with Rec8p, for cohesion and recombination
SMC_N
phylogenetically
0.2
conserved
cohesin
SMC chromosomal
complex (1e-05)
0.006
9
SMC3: Subunit of the multiprotein cohesin complex VS.[KEN][LEQ]
34
in mitotic cells; also required, with Rec8p, for cohesion and recombination
SMC_N
phylogenetically
0.2
conserved
cohesin
SMC chromosomal
complex (1e-05)
0.007
10
G.E[KDM]
WD40
1.E-04
0.2
0.007
10
T..[RIN]R
34 [KR]R
CLV_PCSK_KEX2_1
Zn_clus
1.E-02
0.6
0.007
10
G..N[GSD]
34
Zn_clus
1.E-02
0.6
0.007
10
F..[LAT]K
34of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery;
Y promotes
Pkinase
0.6 addition;
protein
interacts
amino
with
acid
Cns1p,
phosphorylation
Cpr6p, Cpr7p, Sti1p
(0.01)
0.006
10
A[GQV]..A[EAQ]
Ribosomal_60s
1.E-03
0.6
Y
0.007
10
GSP1: GTP binding protein (mammalian Ranp homolog)L.D[ESL]
34 of nuclear
LPDEL
organization,Motif
RNA processing
in CBP forand
interaction
transport; with
regulated
Y
PPARg-LBD
by Prp20p,
IBN_N
(secondary
Rna1p, Yrb1p,
site)
Yrb2p,
1.E-13
Yrp4p, Yrb30p,
0.6 Cse1p
nucleocytoplasmic
transport
homolog
(1e-19)
0.006
10
DBP9: ATP-dependent RNA helicase of the DEAD-box family
E..[ELN]D
involved in biogenesis
Pkinase
1.E-02
0.6
0.006
9
binding
D..L[LSP]
34 D..LL
Di-Leu motif for receptor endocytosis (recognized
IBN_Nby VHS domain
1.E-02
of GGA 0.7
proteins)nucleic acid binding (1e-10)
0.007
10
RVS167: Actin-associated protein, subunit of a complex
[GVC]S..E[EHT]
34 in regulation
[ST]..E of actin cytoskeleton,
Casien kinase
endocytosis,
II consensus
and viability
phosphorylation
HEAT
site or osmotic stress;
1.E-02
homolog of 1
mammalian amphiphysin
0.007
10
TLG2: Syntaxin-like t-SNARE that forms a complex [DRN]T[ARE]G
with Tlg1p and Vti1p and mediates
Y Vps45p, which
Rasprevents Tlg2p1.E-04
degradation and
1.1also facilitates
GTPase
t-SNARE
activity
complex
(1e-04)
formation
0.006
9
hydrolase activity
T..E
34 [DE]AT..[DE]PWG[PA]
PI(4,5)P2 binding motif in epsin
UCH
1.E-08
1.2
0.007
10
E..S[AVG]
Helicase_C
1.E-14
1.2
Y
0.007
10
PRE1: Beta 4 subunit of the 20S proteasome; localizes
A[RIQ].[ALK]A
the cell EAIYAAPF
cycle
Abl kinase substrate motif
Proteasome
1.E-03
1.2
0.007
10
response to stimulus
K..S[ESP]
34 K..[ST]
BRCT
1.E-02
1.3
Y
0.007
10
[KAD]K..[NIM]D
IBN_N
1.E-02
Yrp4p, Yrb30p,
1.3 Cse1p
nuclear
and Kap95p;
transport
yeast(1e-04)
Gsp2p homolog
0.007
10
mitochondrial part
LD..[KAR][TVM]R
34
Mito_carr
1.E-20
1.5
0.008
9
ribosome
A[ARG].[KPY]A
34
Ribosomal_60s
1.E-02
1.5
ribosome (1e-49)
0.007
10
RPN12: Subunit of the 19S regulatory particle of the[ARQ]A.G[LRM]
34 lethal with RPT1, which is an ATPase component of the 19SYregulatory particle;
HEATphysically interacts
1.E-02with Nob1p
1.5and Rpn3p
0.006
10
hydrolase activity
E[IRC]L
34 GFRGE[AG]L DNA_MISMATCH_REPAIR_1 PATTERN ABC_tran
1.E-05
1.6
Y
0.007
10
N.[ISC]D
34 N.[TS]
Y
Ras
1.E-08
1.6
Y
0.007
10
localization
[LFS]D..K[TVC]R
34
Mito_carr
1.E-32
2
0.008
10
[GKM][DKV]DT
34cytoplasmic
[ASL][FY]SGG[LV]DT[ST]
vesicles; essential
ARGININOSUCCIN_SYN_1
for post-Golgi vesicle transport
PATTERN
Y
Pkinase
1.E-09
2.2
0.006
9
IMP3: Component of the SSU processome, which isD[KGW].[VTA]K
34
essential protein that interacts with Mpp10p and mediates
Y interactions
WD40
of Imp4p and Mpp10p
1.E-04
with U3 snoRNA
2.3
Y
0.007
8
catalytic activity
WD.A[GQK][QPE]
34 WDL
Binding motif for AP-2 and clathrin heavy chain
Ras
ear
1.E-27
2.4
0.008
10
UBP10: Ubiquitin-specific protease that deubiquitinates ubiquitin-protein
E..[LIC]L
moieties; 34
may regulate
[DE]...L[LI]
silencing by acting
AP complex
on Sir4p;deleucine
involved in sorting
motif
regulating
Pkinase
Gap1p and 1.E-21
2.6
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-21)
Y
0.006
9
P[TNV].I[QC]
34
and is required for 60S ribosomal subunit biogenesis; constituent
Y
of 66S
DEAD
1.E-09 member3.2
of the ODN
RNA
family
helicase
of nucleolar
activity
G-proteins
(1e-08)
0.005
9
YAP1: Basic leucine zipper (bZIP) transcription factor N[IN][NEL]T
tolerance;
IETD
activated by H2O2
Protease
through the
Caspase
multistep
8-stringent
formation of disulfide Bromodomain
bonds and transit from the
1.E-03
cytoplasm to3.2
the nucleus;
nucleoplasm
mediates resistance
part (1e-11)
to cadmium
Y
0.007
10
L.Q[DHE]
acid metabolism
34 LSQE
zf-C2H2
1.E-06
3.4
Y
acid metabolism
0.007 (1e-15)9
D[GDS].I[KRA]
WD40
1.E-04
3.9
nucleolus (1e-19)
Y
0.007
10
nuclear lumen
[RNK]E[LTN]A
34
DEAD
1.E-08
4
Y
0.007
10
nucleus
WY..[RSN][LFI]
34 PWY[ST][ST]RLSRP1_TIP1 PATTERN
SRP1_TIP1
1.E-55
4
cell wall (0.001)
0.007
10
[ACM][DW]FG
34 LFG
Y
cysteine
Pkinase
proteinase 1.E-26
4.1
0.007
9
G[LMQ].Y[LDE]H
34 Y[AGSTDE]
Src kinase substrate motif
Pkinase
1.E-14
4.2
0.007
10
E[NIW].L[LIR]
1.E-22
4.2
0.007
10
[VFY]A[IVE]K
Pkinase
of both tRNA1.E-17
synthetases and
4.3
ensuresprotein
their correct
kinase
localization
activity
to the
(1e-17)
cytoplasm
Y
0.007
10
cellular macromolecule metabolism
[ACV]D[FHT]G
34 [LIVMFGAC][LIVMTADN][LIVFSA]D[ST]G[STAV][STAPDENQ]
ASP_PROTEASE PATTERN
Pkinase
1.E-23
4.4
0.007
10
RNA processing
P[TDG]R[ENF]L
34 [AG]R
DEAD
1.E-13
4.6
0.006
9
R.[GKA]R
required for export
34of 60S
[AG]R
ribosomal subunits
Protease
from the nucleus
Helicase_C
1.E-02
5
Y
0.006
10
[KMT]P.N[ILMV]
34 [ST]P
LIG_WW_4LIG_WW_4
Y
Pkinase
1.E-32
5.2
Y
0.007
8
F.[QRC]R
34 [KR]R
CLV_PCSK_KEX2_1
zf-C2H2
1.E-03
6
0.007
10
F.[QRC]R
34 [KR]R
CLV_PCSK_KEX2_1
zf-C2H2
1.E-03
6
0.007
10
A[CIF].[LGV]F
34 that controls growth in response to nutrients by regulating translation, transcription,
GATA ribosome1.E-05
6.8 transport
regulation
and autophagy;
of nitrogen
involved
utilization
in meiosis (1e-05)
Y
0.007
10
L[MCQ][INL]A
34 thatYL[VMAY]I
controls growth in Sorting
responsenexin
to nutrients
1 (Binding
by regulating
motif),translation,
Lysosomal
transcription,
targeting
GATA motif
ribosome
in EGFR
1.E-04
6.8 transport
plasma
and autophagy;
membrane
involved
(1e-06)
in meiosis
Y
0.007
10
N.[DSG]D
34 N.[TS]
0.007
10
[ISN]S..[VTQ]T
34 S..[ST]
Casein Kinase I consensus phosphorylation site (N-term Ser must first be phosphorylated)
Y
0.007
10
cellular localization
[EMV]N..[KMS]E
34
0.007
10
[QDE]L.Q[EFS]
34
0.007
10
DNA metabolism
PS[TND][KVG]
34
0.007
9
mitochondrial part
T..N[AHN]
34
0.007
10
[VIG]I..L[ILF]
34
0.007
9
I[NDG].L[KMS]
34
0.007
10
endomembrane system
[FLI]SF[GNL]
34 RK.SF
PKCepsilon kinase phosphorylation site (peptide screen)
0.007
10
E.I[DNEQ]
34 YE.[IV]
SH2 ligand for Fes (Tyr must be phosphorylated)
0.007
10
FG[SIT][GIK]
34 RRFGS[MLVIF]RR[MLVIF]
MEKK kinase substrate motif
Y
0.007
10
FG[SIT][GIK]
34 RRFGS[MLVIF]RR[MLVIF]
MEKK kinase substrate motif Y
Y
0.008
10
plasma membrane
W..[RVT]L
34
0.007
10
mitochondrial membrane
KR[KHR]
34 KR
CLV_PCSK_PC1ET2_1
0.007
10
mitotic cell cycle
Q.[QLV]Q
34
Y
0.007
10
secretory pathway
I[ALV]..L[ELD]
34
Y
secretory pathway (1e-89)
Y
0.007
10
cytoskeleton
[LNT]DK[KDY]F
34
0.005
7
[LTK]QR[KQH]
34 [ST]Q
0.007
10
mitochondrion
R.[YFM]S
34 R.[FY]S.P
14-3-3 binding motifs, Ser must Y
be phosphorylated
0.007
10
CLB5: B-type cyclin involved in DNA replication during SDD[EFN]
phase; activates Cdc28p 34
to promote
G[IVT][LVAC][LVAC][IVT]D[DE][FL][DNST]
initiation of DNAMCM_1
synthesis;
PATTERN
functions in formation of mitotic
Y
spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.007
10
HSP82: Hsp90 chaperone required for pheromone [KMW]S.G[TRF]
34of Hsf1p;
STGdocks with Tom70p
EH(3)
forEF
mitochondrial
hand domain
preprotein
binding
delivery;
motif promotes
of EPS15,
telomerase
Class II DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
0.006
9
HSP82: Hsp90 chaperone required for pheromone [PTW][QNE]..KV
34of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
Y
0.006
10
TSC13: Enoyl reductase that catalyzes the last step in
F[VLH].V[ISN]
each cycle of very long chain
35fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p
PWP2: Conserved 90S pre-ribosomal component essential
[KAV]K..K[RHF]
for proper endonucleolytic
35 cleavage
KR of the 35 S rRNA
CLV_PCSK_PC1ET2_1
precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects
rRNA
in cell
processing
cycle and bud
(1e-22)
morphogenesis
RPB5: RNA polymerase subunit ABC27, common to[GWV]R[LVG]P
RNA polymerases I, II, and III;35
contacts
[AG]R
DNA and affects Protease
transactivation
protein_40_YPL204W
2 HRR25: Protein kinase involved in regulating diverse[NF]IL[KPL]K
34 LLKIL
AP-2 binding
segregation;
motif in CXCR2
binds the receptor
CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
0.004
8
protein_40_YPL204W
2 HRR25: Protein kinase involved in regulating diverse[TRI]EF[PFV]D
34 F.D.F
LIG_AP2alpha_1
segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
0.004
8
protein_40_YPL153C
2 RAD53: Protein kinase, required for cell-cycle arrest [AIN]TG[NEY]
activated
LP.TG
C-terminal when
sorting
interacting
signal which
targets surface proteins
Rad9p; also
of Staphylococcus
interacts with ARS1
aureus
and plays
to the
a role
cellinwall
initiation
peptidoglycan;
of DNA replication
Sortase cleaves between Thr and
Y Gly and C-termini
0.007
is used for 10
protein_40_YPL153C
2 RAD53: Protein kinase, required for cell-cycle arrest[TDE]N..[SKH]H
Y
0.006
10
protein_40_YPL018W
2 CTF19: Outer kinetochore protein, required for accurate
L[LSD][EIL]E
mitotic chromosome segregation;
component of the kinetochore
sub-complex COMA (Ctf19p,
Y Okp1p, Mcm21p, Ame1p) that functions as a platform for
chromosome,
kinetochore assembly
pericentric region (1e-11)
0.007
9
protein_40_YOR310C
2 NOP58: Protein involved in pre-rRNA processing, 18S
SD..S[SED][GIK]
34synthesis;
SD.Ecomponent of Casein
the smallkinase
subunitIIprocessome
substrate motif
complex, which is required for processing of pre-18S rRNA
nucleolus (1e-04)
0.005
8
protein_40_YOR133W
2 EFT1: Elongation factor 2 (EF-2), also encoded by [VGH]G..[ATS]G
34
carboxylic
ADP-ribosylated
acid by
metabolism
diphtheria toxin
(0.01)
0.007
10
protein_40_YOR133W
L..[ART]G
34 LP.TG
C-terminal
contains
sorting
diphthamide,
signal which
the unique
targets
posttranslationally
surface proteins
modified
of Staphylococcus
histidine residue aureus
specifically
to
translation
the
ADP-ribosylated
cell wall
elongation
peptidoglycan;
by diphtheria
factor
toxin
Sortase
activitycleaves
(0.001)
between Thr and Gly and C-termini
0.006
is used for 10
protein_40_YOR061W
2 CKA2: Alpha' catalytic subunit of casein kinase 2, aK[PEY]..AK[AKI]
34in cell
[PT]GKHG.AK
IF5A_HYPUSINE
the holoenzyme
PATTERN
also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
0.004
8
protein_40_YOR039W
2 CKB2: Beta' regulatory subunit of casein kinase 2, a Ser/Thr
[SY][LI].RLR
34 in cell growth and proliferation; the holoenzyme also containsYCKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
0.004
7
protein_40_YOR039W
2 CKB2: Beta' regulatory subunit of casein kinase 2, aR[ARI].L[KN]S
34 in cell
R.L
Cyclin A
themotif
holoenzyme
that binds
alsocdk2
contains
complexes
CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
0.004
7
protein_40_YOR016C
2 ERP4: Protein with similarity to Emp24p and Erv25p, member
II..[ITV][IFA]
of the p24 family involved
34 in ER to Golgi transport
0.007
10
protein_40_YOL086C
2 ADH1: Alcohol dehydrogenase, fermentative isozyme
[KDM]TQ[KNR]
34 [ST]Q
ATM kinase
of acetaldehyde
phosphorylation
to ethanol,site
the last step in the glycolytic pathway
0.005
8
protein_40_YNL289W
2 PCL1: Pho85 cyclin of the Pcl1,2-like subfamily, involved inG.G
entry into the mitotic cell
34cycleG.G..G
Phosphate, FAD,
localizes
NADH,
to sites
binding
of polarized
motif cell growth
0.006
10
protein_40_YNL154C
[IDT]K.V[KSG]
34
Y
0.006
10
protein_40_YNL154C
E[GNQ]..[PIE]K
34
Y
0.006
10
protein_40_YNL118C
L[DNC]..N[FQP]
34
cytoplasmic mRNA processing body (1e-05)
0.006
9
protein_40_YNL118C
R[RN]S[KP]R
34 SPRK
the 5' cap structureCDK2
from mRNAs
kinaseprior
phosphorylation
site (peptide
member of
screen)
the Nudix hydrolase family
Y
0.004
8
protein_40_YNL096C
R[RAH].[AGF]R
34Rps7Ap;
[AG]R
interacts with Kti11p;
Protease
deletion
matriptase
causes hypersensitivity
protease siteto zymocin; has similarity to rat S7 and Xenopus S8 ribosomal
cytosolic
proteins
0.006
10
protein_40_YMR216C
2 SKY1: SR protein kinase (SRPK) involved in regulating
[DSQ]A.[QAP]E
metabolism and cation homeostasis; similar to human SRPK1 Y
0.006
9
protein_40_YMR049C
2 ERB1: Protein required for maturation of the 25S and 5.8S
A.[GRE]K
ribosomal RNAs; constituent
34 ofKAPRK[QH][LI]
66S pre-ribosomalHISTONE_H3_1
PATTERN
to mammalian Bop1
nucleolus (1e-21)
0.006
9
protein_40_YMR047C
SG..[FNC][GKP]
of the SG.G
Glycosaminoglycan
GLFG motif that interacts
attachment
with Y
site
mRNA export factor Mex67p and with karyopherin Kap95p;protein
homologous
export
to Nup100p
from nucleus (1e-22)
Y
0.007
9
protein_40_YML085C
L[VCE][GQH]G
0.006
9
protein_40_YML085C
T[RDW]..[VLK]E
0.007
10
protein_40_YML010W
V.R[TEY]
34
of transcription elongation; Spt4p-Spt5p complex also plays
Y a role in pre-mRNA processing
0.006
10
protein_40_YLR423C
2 ATG17: Scaffold potein responsible for pre-autophagosomal
[RF]I.[KQ]AQ
0.004
7
protein_40_YLR249W
2 YEF3: Translational elongation factor 3, stimulates the
D[SAE].R[EFG]
binding of aminoacyl-tRNA 34
(AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal
Y complex; contains two ABC cassettes; binds and hydrolyses ATP
Y
0.007
10
protein_40_YLR197W
D[TIY]LL[TFP]
34 snoRNP
LLTP
complexes thatWD40
domain of Cdc4
of pre-rRNA
binding motif,
duringThr
its maturation;
must be phosphorylated,
overexpression causes
CPDspindle
motif orientation
snoRNA
defects
binding (1e-04)
Y
0.004
8
protein_40_YLR129W
2 DIP2: Nucleolar protein, specifically associated with [IQC]I..[TMQ]P
34 ribonucleoprotein
[ST]P
complex
LIG_WW_4LIG_WW_4
known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the
rRNA
activeprocessing
pre-rRNA processing
(1e-08)complex
0.004
8
protein_40_YLR075W
2 RPL10: Protein component of the large (60S) ribosomalR..A[RGN]
subunit, responsible for joining
34 the 40S and 60S subunits; regulates translation initiation; has
Y similarity to rat L10 ribosomal protein and to members of
cytosolic
the QM gene
ribosome
family (sensu Eukaryota) (1e-19)
0.006
10
protein_40_YLL034C
2 RIX7: Putative ATPase of the AAA family, required for[KAT]EK[KIM]
subunits
[ST]E
from the nucleus;Gdistributed
protein-coupled
between receptor
the nucleolus,
kinase
nucleoplasm,
1 substrate
andmotif
nuclear periphery depending on growth conditions
nucleolus (1e-07)
0.007
10
protein_40_YKL014C
[QV]T.L[SE]K
0.004
9
protein_40_YJR145C
2 RPS4A: Protein component of the small (40S) ribosomalK..[KAE]A
Y
0.006
9
protein_40_YJR066W
2 TOR1: PIK-related protein kinase and rapamycin target; subunit
F.[IAV]A
of TORC1, a complex
34 that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport
plasma
and autophagy;
membrane
involved
(1e-15)
in meiosis
0.006
9
protein_40_YJL177W
RA.[KRG][VYG]
to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins
0.007
10
protein_40_YJL095W
2 BCK1: Mitogen-activated protein (MAP) kinase kinase
[KQW][TYS].SP
kinase SP
C signaling pathway,ERK1,
which controls
ERK2 Kinase
cell integrity;
substrate
upon activation
motif by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.007
10
protein_40_YJL092W
2 SRS2: DNA helicase and DNA-dependent ATPase involved
Q..E[KQV]
0.006
10
protein_40_YJL074C
EV..[IVG][EKL]
34
in mitotic cells; also required, with Rec8p, for cohesion and
Y recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
Y
0.007
10
protein_40_YJL074C
F[TRH][VYI]K
34 FTY
in mitotic cells; alsomTOR
required,
kinase
with Rec8p,
substrate
for cohesion
motif and recombination during meiosis; phylogenetically conserved
cohesin
SMC chromosomal
complex (0.001)
Y
0.005
10
protein_40_YIL094C
F[IKM].G[DQY]
0.005
8
protein_40_YIL035C
2 CKA1: Alpha catalytic subunit of casein kinase 2, a [VG][LFK]..TSA
34in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
0.004
7
protein_40_YHR196W
[DIE][TAK]LLT
34 the
LLTP
U3 snoRNA that isWD40
involved
domain
in processing
of Cdc4
of binding
pre-18S rRNA
motif, Thr must be phosphorylated, CPD motif
0.004
10
protein_40_YHR196W
[SRA]VA[QDC]
Y
0.006
10
protein_40_YHR196W
2 UTP9: Nucleolar protein, component of the small subunitE.[SVQ]G
Y
nucleolus (1e-22)
0.006
9
protein_40_YHR082C
2 KSP1: Nonessential putative serine/threonine protein kinase
[IRT]G.S
Y
0.006
10
protein_40_YHR064C
2 SSZ1: Hsp70 protein that interacts with Zuo1p (a DnaJ A..[APC]K
homolog) to form a ribosome-associated
34
complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential
translation
activation
(1e-04)
of PDR1 and PDR5; binds ATP
0.006
10
protein_40_YHR064C
2 SSZ1: Hsp70 protein that interacts with Zuo1p (a DnaJ G.[KYR]A
34 G[KR][KR]
complex thatAmidation
binds the ribosome
after cleavage
via the Zuo1p
after subunit;
Gly (must
alsobe
involved
in secretory
in pleiotropic
pathway)
drug resistance via sequential
cytosolic
activation
ribosome
of PDR1(sensu
and PDR5;
Eukaryota)
binds ATP (1e-04)
Y
0.006
9
protein_40_YHL033C
S[LSI]S
to Rpl8Bp
R.S.S.P
and has similarity
14-3-3
to rat binding
L7a ribosomal
motifs,
protein;
Ser must
mutation
be phosphorylated
results in decreased amounts of free 60S subunits
0.006
10
protein_40_YGR218W
[PFG]K[PQC]L
34 from the nucleus
Y
0.007
10
protein_40_YGR218W
A[GNA].T[GSM]
34 from the nucleus
Y
0.007
10
protein_40_YGR218W
2 CRM1: Major karyopherin, involved in export of proteins,D[IPE]A
34 from
the nucleus
DEAD_ATP_HELICASE PATTERN
0.006
10
protein_40_YGL120C
AK.[LTV][ASN]S
RNA processing (0.01)
0.005
9
protein_40_YGL031C
G[KIM]K[VAY]
cytosolicrate
0.006
10
protein_40_YFL039C
2 ACT1: Actin, structural protein involved in cell polarization,
P[PSK]..PA
cytoskeletal
P[ST]
functions
cortical cytoskeleton (1e-08)
Y
0.006
9
protein_40_YER110C
2 KAP123: Karyopherin beta, mediates nuclear import [SGM]F[GDI]A
assembly
[DE][DES][DEGAS]F[SGAD][DEAP][LVIMFD]
into ribosomes and
LIG_AP_GAE_1
import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibitsrRNA
geneticexport
interactions
fromwith
nucleus
RAI1 (1e-09)
0.006
9
protein_40_YER074W
RA.[KRQ][VGK]
Y
0.006
10
protein_40_YER036C
2 ARB1: ATPase of the ATP-binding cassette (ABC) family
AA.[KGS][KVD]
ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p translation (1e-08)
0.007
10
protein_40_YER018C
A.[NVE]N
Ndc8034
microtubule
clustering associated complex (0.001)
Y
0.006
9
protein_40_YER018C
Q[RN].K[TFW] Ndc8034
Y
0.005
10
protein_40_YEL037C
AA.[GFW][LTH]
34(with Rad4p)
[LIV]..[LM]L.AA.[FY][LI]
during nucleotide
excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins
0.006
9
protein_40_YDR510W
[HMR]H..H[HPE]
0.006
10
protein_40_YDR471W
[KQR]..AA
Y
0.006
10
protein_40_YDR388W
2 RVS167: Actin-associated protein, subunit of a complexK.[TLA]D
34 in regulation
RKK.[ST]
ZIP kinaseendocytosis,
phosphorylation
and viability
motiffollowing starvation or osmotic stress; homolog of mammalian
cellamphiphysin
cortex part (1e-04)
Y
0.006
10
protein_40_YDR324C
L[DE]..[DTE]DA
Y
0.004
8
protein_40_YDL082W
[RKI][ARG]AR
to Rpl13Bp;
[AG]R
not essential for
Protease
viability; has
matriptase
similarity protease
to rat L13 ribosomal
site
protein
0.007
9
protein_40_YDL015C
2 TSC13: Enoyl reductase that catalyzes the last step L[IYW].[SVF]Y
in each cycle of very long chain
34fatty [ILV][ILV][IFV]Y[TV][IL][ILVP]
acid elongation, localizes
SH2 ligand
to the ER,
for highly
SHP-2N
enriched
(PTP11n)(Tyr
in a structure
must
marking
be phosphorylated)
nuclear-vacuolar junctions, coimmunoprecipitates
fatty acid
with
biosynthetic
elongases Fen1p
process
and Sur4p
(0.01)
0.006
9
protein_40_YCR009C
2 RVS161: Amphiphysin-like lipid raft protein; subunit ofKS.[ED][EP]I
a complex (Rvs161p-Rvs167p)
34 thatS.D
regulates polarization
CAMKII
of the actin
phosphorylation
cytoskeleton, site
endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
0.004
8
protein_40_YBR217W
2 ATG12: Ubiquitin-like modifier, conjugated via an isopeptide
V[KIE]..G[TIS]
bond to a lysine residue
34of Atg5p by the E1 enzyme, Atg7p, and the E2 enzyme, Atg10p,
Y a step that is essential for autophagy
0.007
10
protein_40_YBR109C
2 CMD1: Calmodulin; Ca++ binding protein that regulates
LK[KGP]F[TEK]
0.004
8
protein_40_YBR055C
2 PRP6: Splicing factor, component of the U4/U6-U5 snRNP
T[PIA].E[AFV]
complex
34 [ST]..E
Casien kinase II consensus phosphorylation site
spliceosome (1e-04)
Y
0.007
10
protein_40_YBR010W
2 HHT1: One of two identical histone H3 proteins (see[LNE][LY].TSS
34 forS[ST]
chromatin assembly,
MDC1
involved
BRCT
domain binding motif telomeric and HM silencing; regulated by acetylation, methylation,
regulationand
of mitotic
nucleobase,
phosphorylation
nucleoside, nucleotide and nucleic acid metabolism
0.004 (1e-06)8
protein_40_YBL026W
[ILD]G..A[TAY]G
either GR.A
Protease
Lsm1p
tPAcomplex
proteolytic
involved
site in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.004
7
protein_40_YAR007C
2 RFA1: Subunit of heterotrimeric Replication Protein A (RPA),
D..[LEF]G
34 single-stranded
DH[YF]LGK[EQK]
DNAG6P_DEHYDROGENASE
binding protein involved in DNA
PATTERN
replication, repair, and recombination
0.006
10
protein_40_YAL035W
2 FUN12: GTPase, required for general translation initiation
G[KNI][KYC]V
by promoting Met-tRNAiMet
34 binding to ribosomes and ribosomal subunit joining; homolog
Y of bacterial IF2
0.006
10
protein_40_YAL032C
[KYR][KRQ]..SR
spliceosome
transcription of
(1e-06)
a reporter gene
Y
0.007
10
protein_40_YAL032C
AI..[LYP][LYT]
nuclear
transcription
mRNA
of asplicing,
reporter gene
via spliceosome (0.01)
0.007
10
protein_40_YAL032C
E..I[QIN]
spliceosome
transcription of
(1e-05)
a reporter gene
Y
0.006
10
protein_40_YAL032C
E[SIY]R
34 interacts
[LIVM][ST][KR][LIVMF]E[ST]RP
PREPHENATE_DEHYDR_2
Prp22p and Prp46p; orthologous
PATTERN
nuclear
transcription
mRNA
of asplicing,
reporter gene
Y
0.006
10
protein_40_YAL032C
KI[VPI]
34 interacts
IP[IV]with splicing factors
Crystallin
Prp22p
motif
and for
Prp46p;
dimerization
orthologous to human transcriptional coactivator SKIP and can activate
nuclear
transcription
mRNA
of asplicing,
reporter gene
0.006
10
N[KYQ]..N[ITF]
34
nucleocytoplasmic transport (1e-12)
Y
0.007
9
Q[KSA]S
34 RQ.SFD
CAM Kinase II kinase phosphorylation site (peptide screen)
Y
0.007
10
oshea_Golgi
2 oshea_Golgi
[LV][LI]..PNL
34 P.L
0.004
8
oshea_endosome
2 oshea_endosome
RK..[ECW][NWR]
34 RRK.[ST]
vacuolar transport (1e-11)
0.006
10
matsuyama_vacuole
2 matsuyama_vacuole
[VQY][SD]NTL
34 N.LY
Dok1 PTB domain binding motif
vacuole (0.001)
0.006
9
E..N[NLM]
34
spindle (1e-10)
0.009
10
S..[LKH]N
34
spindle (1e-13)
Y
0.008
10
matsuyama_Nucleus
2 matsuyama_Nucleus
D.[EMW]E
34 D.[WF]EH[STA][FY][FY]
SOD_MN PATTERN
0.008
10
matsuyama_Golgi
2 matsuyama_Golgi
[LVM]L.[TGV]V
34
Y
0.009
9
matsuyama_Cytosol
2 matsuyama_Cytosol
[TIE]V.[SET]V
34
0.008
10
matsuyama_Cytosol
2 matsuyama_Cytosol
S.[QVM]R
34 R.DSPVR
14-3-3 binding motif on N-terminal
Y domain of Nitrate Reductase necessary for 14-3-3
purine
binding
nucleotide
for inactivation
binding
in the
(1e-04)
dark
Y
0.008
10
genetic_YPL055C
2 LGE1: Protein of unknown function; null mutant forms abnormally
F.[KTR]D
34
Y
0.006
10
genetic_YNL153C
2 GIM3: Subunit of the heterohexameric cochaperone[NEG]I..N[SCV]L
telomere organization and biogenesis (0.01)
0.005
10
genetic_YLR200W
2 YKE2: Subunit of the heterohexameric Gim/prefoldinPP..[SKN][SVH]
34folding
PP.Y
LIG_WW_1LIG_WW_1
and actin
asexual reproduction (0.01)
Y
0.006
10
genetic_YGL058W
E.[KFR]T repair (with Rad18p),
34
Y
0.006
10
genetic_YGL020C
2 GET1: Subunit of the GET complex; required for the retrievalE.L
of HDEL proteins from
34the Golgi
ENLYFQ[GS]
to the ER in an ERD2
Protease
dependent
TEV -fashion
stringent
and for normal mitochondrial morphology and inheritance
Y
(1e-26) 0.006
10
genetic_YER083C
2 GET2: Subunit of the GET complex; required for meiotic I..L[KQN]
10
genetic_YER083C
2 GET2: Subunit of the GET complex; required for meiotic nuclear
I.K[NFP]
division and for the
34retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function telomere organization and biogenesis (1e-06)
Y
0.006
10
genetic_YEL003W
S[TNR]N
specifically
S[ST]
MDC1 BRCT
and transfers
domain
target
binding
proteins
motif
to it
Y
0.006
10
genetic_YAL024C
2 LTE1: Putative GDP/GTP exchange factor required E[ELN]..[QWY]L
for mitotic exit at low temperatures;
cell cycle
with Ras2p-GTP
(1e-06)
0.006
9
yeast-589_GO-0050896
[PVN]S..[SNP]S
33 S..[ST]
Pkinase
must first be -3.2
phosphorylated)
0.007
10
protein_40_YLR074C
2 BUD20: Protein involved in bud-site selection; diploid
K[KPR].A[KFE]
mutants display a random budding
33 pattern
KR instead of theCLV_PCSK_PC1ET2_1
wild-type bipolar pattern
Histone
1.E-02
-1.9
Y
0.007
10
protein_40_YML069W
2 POB3: Subunit of the heterodimeric FACT complex (Spt16p-Pob3p),
[GH]S..KA[SI]
which facilitates
33 RNA Pol II transcription elongation through nucleosomes by destabilizing and
Histone
then reassembling
1.E-02
nucleosome-1.6
structure;establishment
interacts with DNAand/or
polymerase
maintenance
alpha (Pol1p)of chromatin architecture (0.001) 0.004
8
yeast-341_GO-0045449
H[TFS].E
33 F.E
DNA binding motif in MutS
Y
zf-C2H2
1.E-15
-1.5
0.007
10
half_life_belle_q3
3 half_life_belle quantized 3
L...Q
33 [DE][DE][FL][FL][DE][LM][IL]...Q[GS].R[LM][DE][DE]QR
GoLoco motif, a G alpha binding motif
Zn_clus
1.E-03
-1.5
cell cycle (0.001)
Y
0.014
9
protein_40_YDR324C
[KDN]ED[DEG]
33 the
EDAIY
U3 snoRNA that isAbl
involved
kinase
in substrate
processing motif
of pre-18S rRNA
Y
WD40
1.E-04
-1.4
nucleolus (1e-29)
Y
0.006
10
yeast-544_GO-0016070
2 RNA metabolism
T[GNC].[GLN]KT
33
Helicase_C
1.E-22
-1.3
0.008
10
protein_40_YDR496C
2 PUF6: Pumilio-homology domain protein that binds [HNR]R.[GAP]R
33sequences
[AG]Rin the 3' UTR Protease
and represses
matriptase
its translation,
protease
resulting
site
Y in proper asymmetric
DEAD localization
1.E-05
of ASH1 mRNA
-1.3
0.006
10
matsuyama_periphery
2 matsuyama_periphery
RK[FSP]
33
Y
Pkinase
1.E-03
-1.3
0.008
10
yeast-752_GO-0016787
DK..[TLG][LEW]T
33 K..[ST]
E1-E2_ATPase
1.E-11
-1.2
ATPase activity, coupled to transmembrane movement ofY ions, phosphorylative
0.008
mechanism
10
(1e-12)
yeast-752_GO-0016787
GG..L[NCY][LY]
33 GGQ
N-methylation motif in E. coli, Gln residue in
SNF2_N
methylated, mimics
1.E-03
CCA motif-1.2
at the end of tRNA molecule
0.006
8
yeast-661_GO-0050789
T[AST]A
33 KTPAKEE
GSK-3, ERK1, ERK2, CDK5 substrate motifZn_clus
1.E-04
-1.2
Y
0.007
10
protein_40_YOR181W
2 LAS17: Actin assembly factor, activates the Arp2/3 protein
A[IQT]..[ASL]G
Y patches; homolog
SH3_1 of the human
1.E-10
Wiskott-Aldrich
-1.1syndrome
endocytosis
protein (WASP)
(1e-04)
0.006
10
protein_40_YHR148W
2 IMP3: Component of the SSU processome, which is required
D[ELI]E[DIR]
for pre-18S rRNA processing,
33 WLDLE
essential protein that
14-3-3
interacts
binding
with motif
Mpp10p
from
andpeptide
mediates
screen
interactions
WD40
of Imp4p and Mpp10p
1.E-03
with U3 snoRNA
-1.1
0.007
10
protein_40_YPL153C
Q..L[PKS]
to DNA damage; 33
PHRad9p; also interacts
1.E-02with ARS1
-1and plays a role in initiation of DNA replication
0.006
10
protein_40_YKL021C
2 MAK11: Protein involved in an early, nucleolar stepR[TLW]..A[GQK]
33 essential for cell growth and replication of killer M1 dsRNA virus; contains
DEAD
1.E-02
repeats
-1
0.005
9
yeast-470_GO-0006259
2 DNA metabolism
[IDV]ID[LEG]
33 VEID
Helicase_C
1.E-03
-0.9
Y
0.007
10
protein_40_YPL153C
I...P to DNA damage; 33
Septin
1.E-02with ARS1
-0.8and plays
DNA
a role
damage
in initiation
response,
of DNA replication
Y
0.006
10
protein_40_YNR054C
2 ESF2: Essential nucleolar protein involved in pre-18SK[KVI].K[LAH]
33of theK[KR].[KR]
small subunit (SSU)
Nuclear
processome;
localization
has sequence
motif similarity to mABT1,
Helicase_C
a mouse transcription
1.E-02
activator
-0.8
Y
0.006
10
protein_40_YOL133W
D..[AVK]T
conjugating enzyme
-0.7 or E2)
cullin-RING
(a cullin) subunits
ligaseofcomplex
SCF
(1e-10)
Y
0.006
10
Y..Q
33 Y..Q
LIG_SH2_STAT3
IBN_N
1.E-04
-0.7
Y
0.008
9
half_life_belle_q3
3 half_life_belle quantized 3
I.P
33 YIPP
AT(1) receptor motif necessary for activation
Zn_clus
of Jak/Stat pathway
1.E-02
-0.7
0.014
10
yeast-548_GO-0051641
2 cellular localization
N[ENK]..E[DAM]
33
IBN_N
1.E-03
-0.6
0.007
10
yeast-320_GO-0006355
Q..I[NPY]
33 IY
cFGR and Csk kinase phosphorylation
Y
site Zn_clus
-0.6
0.007
10
yeast-312_GO-0006414
RE..[LA][LK]A
33
GTP_EFTU_D2
1.E-02
-0.6
0.004
8
protein_40_YOL133W
Y[GVK][SEC]N
33(SCF);
KEN
required for Gic2p,LIG_APCC_KENbox_2
Far1p, Sic1p and Cln2p degradation; may tether Cdc34p
conjugating enzyme
-0.6 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(1e-04)
of SCF
Y
0.006
9
protein_40_YMR047C
2 NUP116: Subunit of the nuclear pore complex (NPC) thatSN[PKQ]
of the NPC
N-glycosylation
GLFG motif sitethat interacts
aberrantwith mRNA exportIBN_N
with karyopherin
-0.6
transport (1e-25)
Y
0.006
10
oshea_bud_neck
2 oshea_bud_neck
K[LSP][GSP]T
33 LPTSY
SMAD interacting motif- FM1 in motif for binding
PHin XFoxH1 1.E-03
-0.6
bud neck (1e-25)
0.007
10
protein_40_YOL133W
[DNC]I..[AIQ]V
conjugating enzyme
-0.5 or E2)
cullin-RING
(a cullin) subunits
ligaseofcomplex
SCF
(1e-04)
0.006
10
protein_40_YLR293C
[APR]F[GAW]S
IBN_N
1.E-03
Yrp4p, Yrb30p,
-0.5 Cse1p
nuclear
and Kap95p;
transport
yeast(1e-14)
Gsp2p homolog
Y
0.006
10
protein_40_YJL092W
2 SRS2: DNA helicase and DNA-dependent ATPase involved
S[DKP].I[NTS]
for proper
SP timing of commitment
ERK1,
to ERK2
meioticKinase
recombination
substrate
and transition
motif from IBN_N
Meiosis I to II; affects
1.E-02
genome stability
-0.5by suppressing unscheduled homologous recombination
0.006
10
protein_40_YIL094C
[DVQ]V..[IDG]E
-0.5
Y
0.007
10
protein_40_YBL003C
AV.[KFR][SYP]
33 required for chromatin assembly and chromosome function;YDNA damage-dependent
1.E-04 by Mec1p
-0.5 facilitates
nuclear
DNAnucleosome
repair; acetylated
(1e-05)
by Nat4p
0.007
9
protein_40_YOL133W
DE.[QSR][RSG]
33(SCF);
LPDEL
required for Gic2p,Motif
Far1p,
in Sic1p
CBP and
for interaction
Cln2p degradation;
with PPARg-LBD
may tether Cdc34p
F-box
(secondary
(a ubiquitin
site)1.E-02
conjugating enzyme
-0.4 or E2)
protein
and Cdc53p
catabolism
(a cullin)(0.01)
subunits of SCF
Y
0.006
10
protein_40_YDR328C
2 SKP1: Evolutionarily conserved kinetochore proteinL[LGN].RL[VFE]
that is part of multiple protein complexes,
33
including the SCF ubiquitin ligase complex, the CBF3Ycomplex thatF-box
DNA, and the RAVE
-0.4 complex
ubiquitin
that regulates
ligase assembly
complexof(0.001)
the V-ATPase
0.004
7
protein_40_YBR159W
protein_40_YOR272W
protein_40_YJL074C
protein_40_YJL074C
yeast-215_GO-0005694
yeast-470_GO-0006259
yeast-335_GO-0016772
matsuyama_K_G15
yeast-631_GO-0050794
protein_40_YOR181W
protein_40_YDL014W
protein_40_YLR372W
protein_40_YGL106W
yeast-457_GO-0007001
yeast-255_GO-0042254
yeast-255_GO-0007028
yeast-1433_GO-0006139
protein_40_YNL189W
protein_40_YMR093W
protein_40_YMR047C
protein_40_YBR159W
protein_40_YML007W
genetic_YNL153C
yeast-921_GO-0006810
yeast-290_GO-0009057
yeast-921_GO-0006810
protein_40_YLR222C
protein_40_YMR304W
oshea_spindle_pole
Oshea_mcl
yeast-939_GO-0051234
protein_40_YLL008W
yeast-706_GO-0043412
protein_40_YOL133W
protein_40_YMR093W
protein_40_YKR001C
protein_40_YJR002W
matsuyama_Cytosol
yeast-565_GO-0006464
protein_40_YLL008W
yeast-1721_GO-0016043
protein_40_YBR031W
protein_40_YPL043W
protein_40_YNL186W
protein_40_YER165W
yeast-410_GO-0007049
protein_40_YCR057C
yeast-376_GO-0019219
yeast-752_GO-0016787
yeast-649_GO-0003676
yeast-548_GO-0051641
yeast-523_GO-0030529
yeast-470_GO-0006259
yeast-437_GO-0044429
yeast-436_GO-0031323
yeast-424_GO-0006950
yeast-424_GO-0006950
yeast-271_GO-0045184
yeast-267_GO-0000003
yeast-256_GO-0016021
yeast-244_GO-0000279
yeast-213_GO-0009719
yeast-213_GO-0009719
yeast-1974_GO-0005634
ubiquitin_peng2003
ubiquitin_peng2003
protein_40_YPR144C
protein_40_YPR120C
protein_40_YPR119W
protein_40_YPR010C
protein_40_YPL240C
protein_40_YPL209C
protein_40_YPL153C
protein_40_YPL153C
protein_40_YPL153C
protein_40_YPL146C
protein_40_YPL131W
protein_40_YPL004C
protein_40_YOR181W
protein_40_YOR133W
protein_40_YOL139C
protein_40_YOL135C
protein_40_YOL133W
protein_40_YNL308C
protein_40_YNL308C
protein_40_YNL289W
protein_40_YNL244C
protein_40_YNL154C
protein_40_YNL118C
protein_40_YNL096C
protein_40_YNL069C
protein_40_YNL055C
protein_40_YMR308C
protein_40_YMR128W
protein_40_YMR047C
protein_40_YMR001C
protein_40_YML069W
protein_40_YML056C
protein_40_YLR441C
protein_40_YLR429W
protein_40_YLR197W
protein_40_YLR074C
protein_40_YLR009W
protein_40_YKL203C
protein_40_YKL203C
protein_40_YKL203C
protein_40_YKL180W
protein_40_YKL166C
protein_40_YKL104C
protein_40_YKL065C
protein_40_YKL009W
protein_40_YJR145C
protein_40_YJR066W
protein_40_YJR002W
protein_40_YJL138C
protein_40_YJL095W
protein_40_YJL092W
protein_40_YJL074C
protein_40_YIL133C
protein_40_YIL075C
protein_40_YIL061C
protein_40_YIL035C
protein_40_YIL018W
protein_40_YIL018W
protein_40_YHR079C
protein_40_YHR079C
protein_40_YHR041C
protein_40_YHR010W
protein_40_YHL007C
protein_40_YGR274C
protein_40_YGR274C
protein_40_YGR218W
protein_40_YGR162W
protein_40_YGR040W
2
2
2
2
2
2
2
15
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
13
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
L[PAI].[ITY]A
33
MFS_1 high levels
1.E-02
-0.3
transporter
phytosphingosine
activity
and medium-chain
(1e-07)
ceramides
0.006
10
0.006
10
0.006
9
0.007
10
chromosome
Q.D[LDY]
33 GIQVD
dynein light chain LC8 interacting motif -alternative
SMC_N
1.E-06
0.3
chromosome (1e-97)
0.007
10
DNA metabolism
V[SKQ].[KQP]D
33
SMC_N
1.E-02
0.4
Y
0.007
10
[KDA]K..KR[EAD]
groups
33 KR
CLV_PCSK_PC1ET2_1
Pkinase
1.E-04
0.4
9
matsuyama_K_G15
IF.[VIY]
33 F.[YF]P
DEF motif for ERK docking
MFS_1
1.E-05
0.5
0.030
10
T..[RIN]R
33 [KR]R
CLV_PCSK_KEX2_1
Zn_clus
1.E-02
0.6
0.007
10
[NEA]T..V[PY]
branched
VPactin filaments; localizes
Interleukin
with converting
the Arp2/3 complex
enzyme
to protease
actin
Y patches; homolog
SH3_1 of the human
1.E-04
Wiskott-Aldrich
0.6syndrome
actin
protein
cortical
(WASP)
patch (1e-07)
0.005
9
V..[KNV]D
33 is required for processing of pre-18S rRNA; has similarity toYmammalian fibrillarin
WD40
1.E-02
0.6
nucleolus (1e-34)
0.006
10
II..[ILMV][GWI]
very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation
Sugar_trof sphingolipid
1.E-02
biosynthesis
0.8
integral to membrane (0.01)
0.007
10
[ENC]Q.A[ENT]
33
to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate
UCH
formation and contraction
1.E-02 of the0.8
actomyosin
ubiquitin-specific
ring with targeted membrane
proteasedeposition
activity (0.01)
Y
0.005
9
[AG]Q[ANM]Q
33
Helicase_C
1.E-02
1
Y
(1e-24) 0.007
10
G..[ENG]K
33 Q[MLVI]DG..[DE]
CLV_TASPASE1
WD40
1.E-05
1
0.007
10
G..[ENG]K
33 Q[MLVI]DG..[DE]
CLV_TASPASE1
WD40
1.E-05
1
0.007
10
L[LAV]N
33 HLVNK
Motif for targeting CD44 to basolateral membranes
BRCT
1.E-03
1
0.007
10
SRP1: Karyopherin alpha homolog, forms a dimer with
[NMG]S[LEF]EE
karyopherin beta Kap95p to
33mediate
EEEYF
import of nuclear EGFR
proteins,
kinase
binds the
phosphorylation
nuclear localization
site signal
(peptide
RNase_PH_C
of the
screen)
substrate during import;
1.E-02may also play
1 a role in regulation of protein degradation
0.005
9
[KRQ]L[LYR]A
WD40
1.E-05
1
Y
0.007
10
Q..E[QNR]
with karyopherin
1.1
transport (1e-24)
Y
0.006
10
IFA38: Microsomal beta-keto-reductase; contains oleate L[LWM]G
33 LLG
Beta2-Integrin
mutants exhibit
binding
reduced
motifVLCFAYsynthesis, accumulate
MFS_1 high levels
1.E-02
1.1
transporter
phytosphingosine
activity
and medium-chain
(1e-09)
ceramides
Y
0.006
10
LT.[QLP][QYG]
tolerance;
LLTP
activated by H2O2
WD40
through
domain
the multistep
of Cdc4
formation
bindingofmotif,
disulfide
Thr
Bromodomain
bonds
mustand
be transit
phosphorylated,
from the
1.E-03
cytoplasm
CPD motif
to1.3
the nucleus;
nucleoplasm
mediates resistance
part (1e-13)
to cadmium
Y
0.007
10
S.[RSM]H
specifically
S.R to cytosolic chaperonin
PKC phosphorylation
and transfers target
motif
proteins to it
Kinesin
1.E-02
1.3
cell cycle (1e-07)
Y
0.006
10
transport
V..[VFI]V
33
MFS_1
1.E-04
1.4
Y
0.007
10
macromolecule catabolism
GP..T[PED][YSA]
33 GP
Y
UQ_con
1.E-08
1.4
macromolecule catabolism (1e-08)
0.005
7
transport
A..F[GFW]
33
MFS_1
1.E-08
1.5
Y
0.007
10
[FID]K.[FWY]D
WD40
1.E-02
1.5
0.006
10
UBP15: Ubiquitin-specific protease that may play a role S[NLM]G
33 STG
EH(3) EF hand domain binding motif of EPS15,
Pkinase
Class II
1.E-03
1.6
0.006
10
oshea_spindle_pole
DL..[SPQ][EMI]
33 DLL
Binding motif for clathrin heavy chain ear Kinesin
1.E-03
1.6
0.007
10
Oshea_mcl
I..[FLV]I
33
MFS_1
1.E-11
1.6
0.034
10
[LQV]Y[RTW]G
33 YIGPY
PTB binding motif for NUMB-PTB
Y domain Mito_carr
(does not need to 1.E-14
be Tyr phosphorylated)
1.7
Y
0.007
10
[IKS]G..S[FED]
including
DSG..S
WD40 binding
subunits;
motif,
constituent
Ser residues
of 66SYpre-ribosomal
must be Pkinase
phosphorylated
particles
1.E-11
1.7
Y
0.007
10
H[PEY]N[IVH]
33
Y
UQ_con
1.E-16
1.8
0.007
10
L[PCH]N
33(SCF);
[IL].NP.Y
required for Gic2p,PTB
Far1p,
of Sic1p
Shc interaction
and Cln2p degradation;
motif, Mustmay
be Tyr
tether
phosphorylated,
Cdc34p
F-box (a ubiquitin
motif
1.E-14
conjugating
on autophosphorylated
enzyme
1.8 or E2)
ubiquitin
andNGFR
Cdc53p
ligase
recognized
(a cullin)
complex
subunits
by PI
(1e-11)
domain
of SCF of Src- stringent
Y
0.006
9
[TIA]G..[DYM]K
WD40
1.E-04
1.8
0.006
9
GK..[QY]T[IS]
33
organization, late Golgi-retention of some proteins, regulating peroxisome
SNF2_Nbiogenesis1.E-02
2.3
ATPase activity (0.001)
0.004
7
MPP10: Component of the SSU processome, which
[DGM]G..K[VYN]
33 G..G..K
interacts with and
Sulfonate
controls the
donor
stability
binding
of Imp3p
site and
in sulfotransferases
Imp4p, essential
WD40
1.E-07
to human Mpp10p
2.5
0.006
9
matsuyama_Cytosol
R[LQD]L
33 R[RH][RH][RE]RE[RH]SR[RD]L
CLK2 kinase substrate motif
Y
Pkinase
1.E-04
2.5
ATP binding (1e-11)
0.008
10
I...D
33
Pkinase
1.E-19
2.7
protein modification (10)
Y
0.007
10
[GW]S[FCD]G
including
R.GSF
PKCdeltasubunits;
kinase constituent
phosphorylation
site (peptide
Pkinase
particles
screen)
1.E-10
2.9
0.005
10
V[RQV].[WYN]D
33
WD40
1.E-10
3.1
10
[LFR]DE[AK]D
33 nearly
identical to Rpl4Bp
DEAD_ATP_HELICASE
and has similarity to E. PATTERN
coli L4 and rat L4 ribosomal
DEADproteins 1.E-07
3.3
0.004
7
[RNE]E[LEW]A
and large
[KRHQSA][DENQ]EL
ribosomal subunit
ER_TARGET
biogenesis; constituent
PATTERN
Y
particles;
RNA recognition
3.4
motifs (RRMs)
0.007
10
[LIM]K.[EHD]N
may regulate
[VILMAFP]K.E
silencing by acting
MOD_SUMOMOD_SUMO
on Sir4p; involved in posttranscriptionally
Y
regulating
Pkinase
Gap1p and 1.E-24
3.7
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-22)
Y
0.007
9
KG[TYC][GAH]
complex, mediates
33 interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved
RRM_1
in control of poly(A)
1.E-05
tail length,3.9
interactsmRNA
with translation
metabolism
factor eIF-4G
(0.001)
Y
0.006
10
cell cycle
K[LEY].DF[GSN]
33
Pkinase
1.E-15
4.1
cell cycle (1e-19)
0.008
10
PWP2: Conserved 90S pre-ribosomal component essential
[RHG]R.[AGQ]R
for proper endonucleolytic
33 cleavage
[AG]Rof the 35 S rRNA
Protease
precursor
matriptase
at A0, A1,protease
and A2 sites;
sitecontains Helicase_C
eight WD-repeats; PWP2
1.E-04
deletion leads
5.2
to defects
rRNA
in cell
processing
cycle and bud
(1e-10)
morphogenesis
Y
0.007
10
C[VQA]K
acid metabolism
33 CKPCLK.TC CLUSTERIN_1 PATTERN
Zn_clus
1.E-11
8.4
0.007 (1e-60)
10
hydrolase activity
[DVT]E.[KC]LT
33 [ST]E
ATPase activity (0.01)
0.007
9
[IKY]K..DE[LN]
33
0.008
10
S[SWQ].F[GTM]
33 S..F
LIG_BRCT_BRCA1_1
0.007
10
[KQA]K..K[KRV]
33 KR
CLV_PCSK_PC1ET2_1
0.007
10
DNA metabolism
G[GEY][TNP]TS
33 FRGGT
Phosphoinositide binding motif in ATG18 and ATG21
0.006
10
mitochondrial part
F[QIN]I
33 F.[IV][WFY][WFY][IL][ILM]
EH1 motif binds to groucho/TLE corepressors
0.007
10
QD.[TNY]
0.007
10
response to stress
S[KFQ].R[KSQ]
33
0.007
10
response to stress
VS.[IGA]E
33 [ST]..E
Casien kinase II consensus phosphorylation
Y
site
Y
0.007
10
establishment of protein localization
[LTP]FGS[KNP]
33 LFG
0.006
8
reproduction
S[GHQ].S[THN]
33 S[ST]
Y
0.007
10
[TIG]S..F[TGL]
33 S..F
LIG_BRCT_BRCA1_1
0.007
8
M phase
Q[DIC]D
33 Q[MLVI]DG..[DE]
CLV_TASPASE1
M phase (1e-89)
0.007
9
[IEQ]D.F[NIK]
33 DPF
AP2 binding motif in Synaptojanin
Y 1 and EPS15
0.007
10
[KIR][SER]TI
33
Y
0.007
9
nucleus
G[AGR].[FLY]A
33
plasma membrane (0.01)
0.007
9
ubiquitin_peng2003
I[AYM]..[SVF]NG
33 IY
0.006
10
ubiquitin_peng2003
IL.[LCW][VAL]P
33 VP
0.006
9
ES.[IVE][EWD]
and nuclear
YESP
Vav SH2subunits
nucleolus (1e-14)
Y
0.007
10
KM..[IPT][DVQ]
Y
0.004
8
LN..[VRN]E[ESM]
33the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
0.005
10
RPA135: RNA polymerase I subunit A135
[YHW]G.A[SYN]
33
0.004
7
D[SGV][KWV]S
Y
0.006
10
GA..[ERC][NQH]
attachments; helps
0.004
8
RAD53: Protein kinase, required for cell-cycle arrest[EYP]T..[KWA]P
activated
T..[SA]
FHA of KAPP
when
binding
interacting
motif,
withThr
hyperphosphorylated
must be phosphorylated
0.006
9
RAD53: Protein kinase, required for cell-cycle arrest [LIC]PQ[AMK]
activated
HPQ
Biotin binding
when
motif
interacting
in streptavidin
Y
0.006
10
RAD53: Protein kinase, required for cell-cycle arrestD[TMW][KLN]T
0.006
10
NOP53: Nucleolar protein; involved in biogenesis of L[LWV].[EGI]H
Y
0.005
10
RPL5: Protein component of the large (60S) ribosomal subunit
AR..[ART]
with similarity to E. 33
coli L18[AG]R
Protease
proteins;matriptase
binds 5S rRNA
protease
and is required
site
Y
for 60S subunit assembly
0.006
9
[IGR][SH]..GE
Y
0.005
7
L[AM]..L[AR]A
branched
[LV][DE].[LM][LM]..L
LIG_PXLLIG_PXLLIG_PXL
with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
0.004
7
EFT1: Elongation factor 2 (EF-2), also encoded by EFT2;
G[VGI]E[TLC]
33 EGGELGY
PHOSPHOKETOLASE_1
contains diphthamide, the
PATTERN
unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
Y
0.006
8
CDC33: Cytoplasmic mRNA cap binding protein; theK[NRI]..T[GAT]
33 forKR
CLV_PCSK_PC1ET2_1
mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p)
0.007
10
[MIG]N..[NMT]N
33
subunits to form the RNA polymerase II holoenzyme;Yessential for transcriptional regulation
0.006
10
E[TWI][VFK]K
Y
0.007
10
[AIL][LPV].DLD
and functionally
D.D
interacts with
Ribose
Krr1pmoiety of UDP and manganese binding site in glucuronyl transferase
0.004
7
[VDH]K..[RKI]K
and functionally
K[KR].[KR]
interacts with
Nuclear
Krr1p localization motif
nucleolus (1e-08)
0.007
10
PCL1: Pho85 cyclin of the Pcl1,2-like subfamily, involvedP.[NDY]A
33cycleNP.Y
LIG_PTB_1LIG_PTB_1
localizes to sites of polarized cell growth
0.006
10
SUI1: Translation initiation factor eIF1; component of a QVN[ECQ]
complex involved in recognition
33 of the initiator codon; modulates translation accuracy at the initiation phase
0.004
7
L.E[GNE]
33
0.006
10
F[IRP]..L[RM]
33 DFR..L
the 5' cap structureActin
from mRNAs
bindingprior
motif
to on
theirMyosin
degradation;
light chain
member
kinase
of the Nudix hydrolase family
Y
0.004
9
RPS7B: Protein component of the small (40S) ribosomalS.L[SPF]
33Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
0.006
10
RPL16B: N-terminally acetylated protein component of the
SL[SLG]
has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
0.006
10
POR1: Mitochondrial porin (voltage-dependent anion
[EHS]P..[NHF]E
channel), outer membrane protein
33 required
[ST]P for the maintenance
LIG_WW_4LIG_WW_4
of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
0.005
8
[TGA]G..F[GQP]
33nuclear
[AC]GL.FPV
import receptor for
HISTONE_H2A
specific proteins,
PATTERN
including Pdr1p, Yap1p, Ste12p, and Aft1p
0.006
10
ECM16: Essential DEAH-box ATP-dependent RNA helicase
E[KEI]K[DM]
specific to the U3 snoRNP,
33 predominantly nucleolar in distribution, required for 18S rRNA
Y synthesis
0.006
10
[TMN]T..F[GVW]
of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p;nucleocytoplasmic
transport (1e-10)
Y
0.006
10
DT..[APM][KQF]
at budT..[SA]
neck, nucleus and SPBs;
FHA of
has
KAPP
multiple
binding
functions
motif,
in mitosis
Thr must
and cytokinesis
be phosphorylated
through phosphorylation of substrates; may
mitotic
be a Cdc28p
cell cycle
substrate
(0.01)
0.005
9
[ESM]E[DKT]E
which facilitates
33 RNA[ST]E
Pol II transcription G
elongation
protein-coupled
through nucleosomes
receptor kinase
by destabilizing
1 substrate
and motif
then reassembling nucleosome structure;RNA
interacts
elongation
with DNA polymerase
from RNAalpha
polymerase
(Pol1p)
II promoter (1e-19)
0.007
10
G[SAK][RF]P
33 [RHQ][ST]W[GSA]GARPE
NODA family
PATTERN
in S. cerevisiae, constitutively expressed
0.004
8
RPS1A: Ribosomal protein 10 (rp10) of the small (40S)
[AKG]A..[ADC]E
Rps1Bp and has similarity to rat S3a ribosomal protein
0.007
9
CRN1: Coronin, cortical actin cytoskeletal componentL[SLI]R[AGK]
33
0.006
10
[DTI]S[LKR]D
33 snoRNP
S.D complexes thatCAMKII
phosphorylation
of pre-rRNA
site during its maturation; overexpression causes spindle orientation
nucleolus
defects(1e-16)
0.006
10
BUD20: Protein involved in bud-site selection; diploid
[KRA]P..[KRC]A
33 pattern
KP..[QK]
instead of theLIG_SH3_4LIG_SH3_4
wild-type bipolar pattern
0.005
9
RLP24: Essential protein with similarity to Rpl24Ap KQ.[RKH][LER]
and Rpl24Bp, associated with 33
pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis
0.006
10
[AIM]LA[EYA]
33 that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization plasma
involved in meiosis
0.006
10
[LQV]T..Q[DCA]
33 that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization actin
of the actin
cytoskeleton
cytoskeleton;
organization
involved in meiosis
0.005
9
V[INF]..[NYW]V
33 that regulates growth in response to nutrients and TORC2, aYcomplex that regulates cell-cycle dependent polarization plasma
involved in meiosis
0.005
9
[AK]A..[ACD]E
to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
Y
0.006
10
M[KY]..A[LVK]
33 in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP;
endocytosis
partially redundant
(0.01) with Tpk1p and Tpk2p
0.005
9
A[AGC].[LVC]K
of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis
translational elongation (0.01)
0.006
8
YET1: Endoplasmic reticulum transmembrane protein;[FIG]I..[IYV]I
33based on co-purification experiments; homolog of human BAP31 protein
0.007
10
KR..[VTE][EKD]
nucleolus
KR
CLV_PCSK_PC1ET2_1
Y
0.006
10
[HER]R.[GAL]R
20S pre-rRNA
[AG]Rprocessing; identical
Protease
to matriptase
Rps4Bp and protease
has similarity
siteto rat S4 ribosomal protein
0.007
10
A[LGF].G[EFV]
plasma
and autophagy;
membrane
involved
(1e-13)
in meiosis
0.006
9
MPP10: Component of the SSU processome, which is
Q[ITG]..K[KL]
33
nucleolus (1e-12)
0.006
9
TIF2: Translation initiation factor eIF4A, identical to[TWC]N..D[LMC]
Tif1p; DEA(D/H)-box RNA helicase
33 that
NK.D
Motif for
to RNA
specificity
binding of
andguanine
unwinding;
in purine
forms a binding
dumbbellproteins
structure of two compact domains connected by a linker; interacts with eIF4G
0.004
8
[DNW]E..[EKG]E
kinase C signaling pathway, which controls cell integrity; upon activation
Y
by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.006
10
RK[LY]Q[EVS]
for proper
[RK]R[RK]L
Cyclin/CDK2
to meioticbinding
recombination
motif and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
0.004
7
R[GF][KED]D
33 RGD
in mitotic cells; alsoLIG_RGDLIG_RGD
required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
0.005
9
AG[KR]
33 G[KR][KR]
Amidation
has similarity
after
to Rpl16Bp,
cleavageE.after
coli L13
Glyand
(must
rat L13a
be inribosomal
secretory
proteins;
pathway)
transcriptionally regulated
cytosolic
by Rap1p
0.006
10
RPN2: Subunit of the 26S proteasome, substrate of the
[LQM]K.[YC]E
N-acetyltransferase Nat1p33
YE
TPK-IIB/P38Syk kinase phosphorylation site (peptide screen)
protein modification (0.01)
0.004
8
SNP1: Component of U1 snRNP required for mRNA[AYC]E..G[DHP]
interact
YE
TPK-IIB/P38Syk
to regulate polyadenylation;
homolog of human
site (peptide
U1 70Kscreen)
protein
0.005
10
CKA1: Alpha catalytic subunit of casein kinase 2, a KEL[IRM][SRA]
33in cellL[IVLMF].[IVLMF][DE]
the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription
establishment
factors and
and/or
all RNAmaintenance
polymerases of chromatin architecture (1e-04) 0.005
9
[ALH][GVC]..RG
33and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures
0.005
10
RPL2B: Protein component of the large (60S) ribosomalS[SNK]S
33and has
R.S.S.P
14-3-3
L2 and
binding
rat L8 ribosomal
motifs, Ser
proteins;
must expression
be phosphorylated
is upregulated at low temperatures
0.006
10
[SDH][SLP]..ED
mediates
EED
Ankyrin
response
B C-terminal
(UPR) by regulating
motif thatHac1p
bindssynthesis
internalthrough
AnkyrinHAC1
repeats
mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.006
9
IRE1: Serine-threonine kinase and endoribonuclease; transmembrane
S[AKI]S protein that33
mediates
R.S.S.P
14-3-3
response
binding
(UPR)
motifs,
by regulating
Ser must
Hac1p
be phosphorylated
synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
Y
0.006
9
TI..[TV]S[IP]
33 SP subunits to formERK1,
the RNA
ERK2
polymerase
KinaseII holoenzyme;
substrate motif
general transcription factor involved in telomere maintenance
0.004
7
[IMG]E.V[ECV]
0.006
10
STE20: Signal transducing kinase of the PAK (p21-activated
S..[APR]K
33in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif bud
present
(0.01)
0.006
10
[INQ]Q.[LFS]Q
33 has [ST]Q
ATM kinase
activity, involved
phosphorylation
in promotersite
binding
Y and G1/S progression
0.007
10
QT..[SHD][KVN]
33 has T..[SA]
FHA of
activity,
KAPP
involved
binding
in promoter
motif, Thrbinding
must and
be phosphorylated
G1/S progression
0.006
7
CRM1: Major karyopherin, involved in export of proteins,R.S[EQH]
33 from
RRR.S
the nucleus
MAPKAPK1 kinase substrate motif
Y
0.006
9
TIF4631: Translation initiation factor eIF4G, subunit GR[GKV][GKY]
of the mRNA cap-binding protein
33 complex
[AG]R
(eIF4F) that also
Protease
contains matriptase
eIF4E (Cdc33p);
protease
associates
site with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p
0.006
10
KSS1: Mitogen-activated protein kinase (MAPK) involved
E[GEQ][TDE]D
in signal transduction pathways
33 EED
that control filamentous
Ankyrin
growth
B C-terminal
and pheromone
motif
response;
that binds
the KSS1
internal
gene
Ankyrin
is nonfunctional
repeats in S288C strains and functional in W303 strains
Y
0.006
10
K.[ARW]K
33 ribosomal
SKRKYRK
subunit
TP1 PATTERN
Brix
1.E-02
-0.2
Y
[RLT]E.L[VQT]
33 [ST]E
in mitotic cells; alsoGrequired,
protein-coupled
with Rec8p,
receptor
for cohesion
kinase
and1recombination
substrate
SMC_N
motif
phylogenetically
0.1
conserved
nuclear
SMC chromosomal
chromosome
ATPase
partfamily
(0.001)
member
K[LTI]..[MCL]E
33 L..[LM]E
in mitotic cells; alsoSec24pSec24pSec24p
required, with Rec8p, for cohesion and
Y recombination
SMC_N
phylogenetically
0.2
conserved
cohesin
SMC chromosomal
complex (0.01)
Y
protein_40_YGR040W
2 KSS1: Mitogen-activated protein kinase (MAPK) involved
K.[DAQ]V
33 [NT]K.D
Motifgrowth
for binding
and pheromone
guanineresponse;
nucleotides
the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
0.006
protein_40_YGL180W
2 ATG1: Protein serine/threonine kinase, required for vesicle formation
T..K
during autophagy
33 and
D.G.T..K.I
Pyrophosphate
targeting (Cvt)
binding
pathway;
motif,structurally
active site
required
for S-Adenosylmethionine
for pre-autophagosome (AdoMet)
formation; forms
synthetase
a complex with Atg13p and Atg17p
0.006
protein_40_YGL137W
2 SEC27: Essential beta'-coat protein of the COPI coatomer,
SAG[DA][DNM]
and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
0.004
protein_40_YGL112C
D[EPW]..[DVR]E
33
of RNA polymerase II and in chromatin modification, similar
Y to histone H4
0.007
protein_40_YGL106W
2 MLC1: Essential light chain for Myo1p, light chain for P[VMY]I[INQ]
33 PWI
Motif in with
SRM160
Myo1p,for
Iqg1p,
binding
and Myo2p
DNA and
to coordinate
RNA
formation and contraction of the actomyosin ring with targeted membrane deposition
Y
0.006
protein_40_YGL031C
[NKC][KQN]TR
cytosolicrate
large ribosomal subunit (sensu Eukaryota) (1e-09)
0.005
protein_40_YFR037C
[FMY]E..[FGA]Q
33and mitotic
YE growth; homolog
TPK-IIB/P38Syk
of SWI/SNF subunit
kinase
Swi3p,
phosphorylation
but unlike Swi3p,
site
does
(peptide
not activate
screen)
transcription of reporters
0.004
R[AGP][APR]R
33and has
[KR]R
CLV_PCSK_KEX2_1
L2 and rat L8 ribosomal proteins
0.006
protein_40_YFR028C
2 CDC14: Protein phosphatase required for mitotic exit;
[VHR]L.[PAE]P
located in the nucleolus until33
liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin
mitotic cellactivity
cycleand
(1e-04)
mitotic exit
0.006
protein_40_YFL037W
K[YFQ].[KQL]M
Y
0.004
protein_40_YER177W
2 BMH1: 14-3-3 protein, major isoform; controls proteomeS.P[QNP]
33bindsKSPP
proteins and DNA,ERK1,
involvedERK2,
in regulation
SAPK,
of CDK5
many processes
and GSK3
including
kinaseexocytosis,
substratevesicle
motif transport, Ras/MAPK signaling,
bud (0.01)
and rapamycin-sensitive signaling
0.006
protein_40_YER165W
2 PAB1: Poly(A) binding protein, part of the 3'-end RNA-processing
N..[GML]N
complex, mediates
33 interactions between the 5' cap structure and the 3' mRNA poly(A)
Y tail, involved in control of poly(A) tail length, interactsmRNA
with translation
metabolism
factor eIF-4G
(1e-11)
Y
0.006
protein_40_YER125W
2 RSP5: Ubiquitin-protein ligase involved in ubiquitin-mediated
ES[PK][RM]Y
functions
YESP
Vav sorting,
SH2 domain
heat shock
binding
response
motifand ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain
0.004
protein_40_YER082C
2 UTP7: Nucleolar protein, component of the small subunitA[ERA]E
33 the
U3 snoRNA that isFGFR
involved
kinase
in processing
substrate
of pre-18S
motif rRNA
Y
0.006
protein_40_YER082C
KA[RVQ][IGD]
0.007
protein_40_YER006W
[EW]I..[SCG]T
required for export
Y
0.005
protein_40_YER006W
Y[KAN].[IT]KS
required for export
0.004
protein_40_YDR510W
A[RAI]R
33 proteins;
[KR]R regulates chromatid
CLV_PCSK_KEX2_1
cohesion, chromosome segregation,
Y
cytosol
ring dynamics
(1e-07)
Y
0.006
protein_40_YDR477W
2 SNF1: AMP-activated serine/threonine protein kinase found
D.[EFT]V
33Snf4pD.D.[TV]
and members of the
Motif
Sip1p/Sip2p/Gal83p
in PRS1 and PRS-2
family; required
required
Y for
fortranscription
phosphatase
of glucose-repressed
activity and saltgenes,
stressthermotolerance,
response
sporulation, and peroxisome biogenesis
0.006
protein_40_YDR414C
2 ERD1: Predicted membrane protein required for the retention
[NFT]V.[LD]F
of lumenal endoplasmic
33 reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.006
protein_40_YDR388W
2 RVS167: Actin-associated protein, subunit of a complexK.[LEG]L
33 in regulation
[VILMAFP]K.E
MOD_SUMOMOD_SUMO
endocytosis, and viability following starvation or osmotic stress; homolog of mammalian
cellamphiphysin
cortex part (1e-04)
Y
0.006
protein_40_YDR365C
[AS]P.[VE]K
33decreased
SP 18S rRNA levels
nucleolus (0.001)
0.005
protein_40_YDR365C
EE..[EAR][ENF]
33decreased
EED 18S rRNA levels
0.007
protein_40_YDR365C
I[SN].F[DI]N
33decreased 18S rRNA levels
Y
0.004
protein_40_YDR356W
[DYE]Q..[VEG]I
cytoskeleton manner
Y
0.005
protein_40_YDR091C
2 RLI1: Essential iron-sulfur protein required for ribosome
[AME][LA]..PA
biogenesis and translation33
initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted
cytosolic
ABC
ribosome
family ATPase
0.005
protein_40_YDR025W
[KGI]RA[IFD]
33 and
FGRA
DNA
coli binding
S17 and rat
motif
S11inribosomal
ssDNA binding
proteins proteins
0.007
protein_40_YDL213C
E[FEM].[EKD]A
nucleolus
been yet identified
0.007
protein_40_YDL212W
2 SHR3: Endoplasmic reticulum packaging chaperone, required
[FIY]I..I[IPC]
for incorporation of 33
amino acid permeases into COPII coated vesicles for transport to the cell surface
amine transporter activity (0.001)
0.006
protein_40_YDL185W
2 TFP1: Vacuolar ATPase V1 domain subunit A containing
QE.[SAD][LVI]
33 sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), whichhydrogen
is a site-specific
ion homeostasis
endonuclease (1e-04)
0.006
protein_40_YDL136W
G[KIP]K[VAK]
33 and
GP
Protease
L35 ribosomal
TTP protein
cleavage site
Y
0.007
protein_40_YDL082W
G[KIY]K[VAY]
to Rpl13Bp;
G[KR][KR]
not essential for
Amidation
viability; has
after
similarity
cleavage
to ratafter
L13 ribosomal
Gly (must
protein
be in secretory pathway)
0.007
protein_40_YDL047W
2 SIT4: Type 2A-related serine-threonine phosphataseG[GYR][NLM]S
33 of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
0.006
protein_40_YBR247C
2 ENP1: Protein associated with U3 and U14 snoRNAs,R[AIE].R[ICT]
33 and
R.[RK]R
CLV_PCSK_FUR_1
synthesis; localized in the nucleus and concentrated in the nucleolus
0.007
protein_40_YBR245C
2 ISW1: Member of the imitation-switch (ISWI) class of[EH]V..[QFL]V
ATP-dependent chromatin remodeling
33
complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex
chromatin
with Ioc3p to
modification
repress transcription
(0.001)
initiation
0.004
protein_40_YBR217W
2 ATG12: Ubiquitin-like modifier, conjugated via an isopeptide
VR..[REF][REP]
33of Atg5p by the E1 enzyme, Atg7p, and the E2 enzyme, Atg10p,
Y a step that is essential for autophagy
0.005
protein_40_YBR154C
2 RPB5: RNA polymerase subunit ABC27, common to [DW]VD[MPS]
RNA polymerases I, II, and III;33
contacts
AEVD
DNA and affects Protease
transactivation
Caspase 10
0.005
protein_40_YBR109C
[ST]EL[SG]N
33 (mitosis,
[ST]Ebud growth, actin
G protein-coupled
organization, endocytosis,
receptoretc.)
kinase
and 1
Ca++
substrate
dependent
motif
processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
0.004
protein_40_YBL027W
A[RAG].[KRY]A
to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while
cytosolic
the double
ribosome
null mutation
(sensu
is lethal
Eukaryota) (1e-23)
0.006
protein_40_YBL002W
P[SAV][KET]K
33 P[ST]
DNA dependent
function;Protein
Rad6p-Bre1p-Lge1p
kinase substrate
mediated
motif
ubiquitination regulates transcriptional activation,
chromatin
meiotic DSB
assembly
formation
orand
disassembly
H3 methylation
(1e-04)
0.006
protein_40_YAR007C
2 RFA1: Subunit of heterotrimeric Replication Protein AQ[LVQ][SRD]P
(RPA), which is a highly conserved
33 single-stranded
[ST]P
DNALIG_WW_4LIG_WW_4
binding protein involved in DNA replication, repair, and recombination
0.005
protein_40_YAL032C
FE[EIM][LRD]
nuclear
transcription
mRNA
of asplicing,
reporter gene
0.006
protein_40_YAL032C
IP[DHN]
33 interacts
PL[ST]PIP[KRH]
CDK4Prp22p
kinase
and
substrate
Prp46p; orthologous
motif
nuclear
transcription
mRNA
of asplicing,
reporter gene
Y
0.006
oshea_mitochondrion
RF[YNK]S
33 RRF.SLR
SLK1 kinase phosphorylation site
Y (peptide screen)
0.007
oshea_cytoplasm
2 oshea_cytoplasm
[LQH][LQT]RP
33 FRPW
TLA domain binding motif in Hkb transcription factor
0.006
oshea_cytoplasm
2 oshea_cytoplasm
[SED]LT[DQM]
33 [PG][LVIPME][DENS]L[VASTRGE]
LIG_CtBPLIG_CtBP
0.006
oshea_ambiguous
2 oshea_ambiguous
E.[NDC]S
Y
site of polarized growth (0.001)
Y
0.006
matsuyama_vacuole
2 matsuyama_vacuole
L[GLI]PS[LSF]
33 P[ST]
vacuole (1e-13)
0.007
K[YRA]..S
33 KKR..S
Phosphorylation site for MLCK Y
spindle (1e-13)
0.008
N[RNK]..D[DYF]
33
spindle (1e-32)
0.008
QQ.[VYC][EKH]
33
Y
0.009
matsuyama_Cytosol
2 matsuyama_Cytosol
N..[TYD]P
33 [ST]P
LIG_WW_4LIG_WW_4
ligase activity, forming aminoacyl-tRNA and related compounds
Y
(0.01)0.008
matsuyama_Cytosol
2 matsuyama_Cytosol
RY
33 DRY
Binding motif for interaction of G-proteins
Y
or Phospholipase D with G-alpha
Y
0.008
E[NMC]L
33 ENLYFQ[GS] Protease TEV - stringent
0.008
Q.[QEM]L
33
cell cortex (1e-09)
Y
0.008
T[ED]I[LTQ]
33
Y
0.008
genetic_YNL153C
P[ITG]P
specifically
TPTP
Motif forand
hydroxylation
transfers target
of proteins
Pro residues,
Yto it which can further be modified with arabinogalactan
chromosome organization and biogenesis (0.001)
Y
0.006
genetic_YLR262C
2 YPT6: GTPase, Ras-like GTP binding protein involved
KN.V[LNP][TGR]
33 for
VPfusion of endosome-derived
Interleukinvesicles
converting
with the
enzyme
late Golgi,
protease
maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.005
genetic_YLR262C
2 YPT6: GTPase, Ras-like GTP binding protein involved in TT[ADS]
33 for
GRART[ST]SFAE
Akt kinasevesicles
substrate
with motif
the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity
establishment
to the humanand/or
GTPase,maintenance
Rab6
of chromatin architecture (1e-14) 0.006
genetic_YLR200W
I.[LDG]Q
33folding
INPISGQ
N-Cadherinand
ligand
actin
Y
0.006
genetic_YLR200W
KR[ELI]
33folding
KR
CLV_PCSK_PC1ET2_1
and actin
0.006
genetic_YDL020C
2 RPN4: Transcription factor that stimulates expressionD[MNR]D[DET]
levels D.D
are in turn regulatedRibose
by the 26S
moiety
proteasome
of UDPinand
a negative
manganese
feedback
binding
controlsite
mechanism;
in glucuronyl
RPN4 transferase
is transcriptionally regulated
DNA metabolism
by various stress
(1e-09)
responses
0.006
ucsf_loc_k_means_G6
6 Sub-cellular localization, 6 clusters
F...[FVY]I
33
MFS_1
1.E-04
1
0.020
protein_40_YBR160W
M..T[TPQ]
32
cellular morphogenesis (0.01)
Y
0.006
protein_40_YBR009C
2 HHF1: One of two identical histone H4 proteins (see alsoK.[SEP]A
32 forRKK.[ST]
chromatin assembly
ZIP
and
kinase
chromosome
phosphorylation
function; contributes
motif to telomeric
Histone
1.E-02
domain involved
-3.6 in maintaining
nuclear chromatin
genomic integrity
(1e-04)
Y
0.006
protein_40_YOL012C
2 HTZ1: Histone variant H2AZ, exchanged for histone[GVH]G[KYQ]G
32 complex;
GGQ involved in transcriptional
N-methylation
regulation
motif inthrough
E. coli,prevention
Gln
Y residue
of the
inHistone
spread
methylated,
of silentmimics
heterochromatin
1.E-05
CCA motif-2.5
at the end
nuclear
of tRNA
chromatin
molecule(1e-06)
0.005
yeast-649_GO-0003676
P.P[SHP]
32 P.P
motif in interleukin 5 receptor necessary forRRM_1
signaling
1.E-08
-2.3
Y
0.007
protein_40_YHR196W
[EDF]E...E
WD40
1.E-02
-2.1
nucleolus (1e-34)
Y
0.006
yeast-248_GO-0016072
2 rRNA metabolism
[ASF]R..D[IVA]
32 [AG]R
DEAD
1.E-12
-2
Y
0.007
protein_40_YFR037C
D[PMD]..[PGE]K
32and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p,HMG_box
does not activate transcription
1.E-03 of reporters
-1.9
protein_40_YER110C
2 KAP123: Karyopherin beta, mediates nuclear import[GSM]AK[PRA]
assembly
GAKRH
into ribosomes and
HISTONE_H4
import of histones
PATTERN
H3 and H4; localizes to the nuclear
Histone
pore, nucleus,
1.E-05
and cytoplasm;
-1.9
exhibitsrRNA
geneticexport
interactions
fromwith
nucleus
RAI1 (1e-08)
Y
0.006
yeast-255_GO-0042254
D[VLK].AR[GRE]
32 [AG]R
DEAD
1.E-08
-1.7
0.006
yeast-255_GO-0007028
D[VLK].AR[GRE]
32 [AG]R
DEAD
1.E-08
-1.7
0.006
yeast-255_GO-0042254
VIN[YGV][DRS]
32
DEAD
1.E-02
-1.3
0.005
yeast-255_GO-0007028
VIN[YGV][DRS]
32
DEAD
1.E-02
-1.3
0.005
protein_40_YPL126W
2 NAN1: U3 snoRNP protein, component of the small (ribosomal)
SK.[IAL][QAP]
32
containing U3 snoRNA; required for the biogenesis of18S rRNA WD40
1.E-02
-1.3
nucleolus (1e-20)
0.006
protein_40_YMR093W
E..E[DKE]
32 RE..E
the U3 snoRNA thatIron
is involved
binding
in processing
motif in ferritin
of pre-18S
L-chain
rRNA
and yeast
WD40
1.E-07
-1.3
nucleolus (1e-35)
0.006
yeast-649_GO-0003676
K.[QDL]E
32 G.[DN]F.K.DE RUBISCO_LARGE PATTERN
RRM_1
1.E-05
-1.1
Y
0.007
yeast-255_GO-0042254
T[GH].[GMY]K
32
Y
Helicase_C
1.E-12
-1.1
Y
0.007
yeast-255_GO-0007028
T[GH].[GMY]K
32
Y
Helicase_C
1.E-12
-1.1
Y
0.007
yeast-1433_GO-0006139
Q.P[TIA]
32 P[ST]
zf-C2H2
1.E-03
-1.1
Y
0.007
protein_40_YLR186W
2 EMG1: Protein required for the maturation of the 18SD[EYL][ESY]D
production;
P.DLS
associated withBinding
spindle/microtubules;
motif on TGIF
nuclear
for CtBP
localization dependsWD40
1.E-02
with Nop14p;
-1.1
may bind
nucleolus
snoRNAs (1e-18)
0.006
protein_40_YGL120C
2 PRP43: RNA helicase in the DEAH-box family, functionsGR[LDV]
I and polymerase
[NS][TS]DAEGR[LVMI]
II transcript
CYTOSOL_AP
metabolism, involved
PATTERN
in release of the lariat-intron
Helicase_C
1.E-02
-1.1
0.006
protein_40_YMR047C
2 NUP116: Subunit of the nuclear pore complex (NPC) thatSA[FLH]
of the [LIVMA].EG[DN]SA.[STAG]
TOPOISOMERASE_II
PATTERN
with mRNA exportIBN_N
with karyopherin-1
Kap95p;nuclear
homologous
transport
to Nup100p
(1e-35)
0.006
protein_40_YGL120C
2 PRP43: RNA helicase in the DEAH-box family, functionsQ.K[QKF]
I and polymerase
GQDQTKQQI
II transcript
43_KD_POSTSYNAPTIC
metabolism, involved in release
PATTERN
of the lariat-intron
Helicase_C
1.E-02
-1
nucleolus (1e-27)
Y
0.006
protein_40_YDL014W
R.[TNL]A
32 is required
R.[ST] for processing
PKA
of consensus
pre-18S rRNA;
phosphorylation
has similarity to mammalian
site
Helicase_C
fibrillarin
1.E-02
-1
Y
0.006
yeast-410_GO-0007049
2 cell cycle
F[DNEQ]K
32
Y
Pkinase
1.E-07
-0.8
cell cycle (1e-19)
0.007
yeast-238_GO-0017111
LV.[VEN][GQM]
32
Helicase_C
1.E-03
-0.7
0.007
yeast-205_GO-0005856
2 cytoskeleton
T..[QSM]E
32 T..[SA]
SH3_1
1.E-02
-0.7
Y
0.007
[EIK]L..[FSC]V
32
RhoGAP
1.E-02
-0.7
bud (1e-06)
0.007
yeast-238_GO-0017111
R.I[TMG]
32
Y
Ras
1.E-06
-0.6
Y
0.007
protein_40_YPL153C
2 RAD53: Protein kinase, required for cell-cycle arrest in K..[NPE]G
1.E-02with ARS1
-0.6and plays
protein
a role kinase
in initiation
activity
of DNA(0.001)
replication
0.006
protein_40_YOL133W
K[SFK]..[EVC]Y
32(SCF);
[EDY]Y
required for Gic2p,TC-PTP
Far1p, Sic1p
phosphatase
and Cln2p substrate
degradation;
motif
may tether Cdc34p
conjugating enzyme
-0.6 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(1e-04)
of SCF
0.006
protein_40_YML085C
VI[SQN][ENI]
IBN_N
1.E-02
-0.6
0.006
protein_40_YLR293C
[TWA]Q..E[LDA]
32 of nuclear
[ST]Qorganization,ATM
RNA processing
and transport; regulated
site
by Prp20p,
IBN_N
1.E-05
Yrp4p, Yrb30p,
-0.6 Cse1p
nucleocytoplasmic
transport
homolog
(1e-06)
Y
0.006
yeast-548_GO-0051641
2 cellular localization
QQ[IEG]
32 S[QT]Q
ATM phosphorylation of this motif on Chk2 IBN_N
1.E-02
-0.5
0.007
protein_40_YOR181W
2 LAS17: Actin assembly factor, activates the Arp2/3 R[EFL]..[EDW]G
SH3_1 of the human
1.E-02
Wiskott-Aldrich
-0.5syndrome
endocytosis
protein (WASP)
(0.001)
0.005
protein_40_YOL133W
D[SIQ]..[KIN]F
conjugating enzyme
-0.5 or E2)
cullin-RING
(a cullin) subunits
ligaseofcomplex
SCF
(1e-04)
Y
0.006
protein_40_YLR293C
[ILA]K..[EYQ]N
IBN_N
1.E-03
Yrp4p, Yrb30p,
-0.5 Cse1p
nuclear
and Kap95p;
transport
yeast(1e-07)
Gsp2p homolog
Y
0.006
protein_40_YGL105W
E..R[NSD]
synthetases (Mes1p
the cytoplasm;-0.1
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-11)
Y
0.006
protein_40_YDL153C
2 SAS10: Component of the small (ribosomal) subunit[NYQ]Q..E[KEH]
Pkinase
disrupts silencing
1.E-05
-0.1
0.005
yeast-648_GO-0050791
I..[LPV]K
32
Zn_clus
1.E-06
0.1
Y
0.007
protein_40_YJL074C
EI.[SLM][LKR]
32 VEID
in mitotic cells; alsoProtease
required, with
Caspase
Rec8p,6for
-stringent
cohesion and recombination
SMC_N
phylogenetically
0.1
conserved
cohesin
SMC chromosomal
complex (0.01)
0.007
yeast-1062_GO-0016020
2 membrane
V.A[VYF]
32
E1-E2_ATPase
1.E-02
0.2
Y
0.007
oshea_bud_neck
2 oshea_bud_neck
L[CSK]I
32 LLKIL
Y
RhoGAP
1.E-06
0.2
0.006
protein_40_YOL133W
A..L[SNV]
conjugating enzyme
0.5 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(1e-10)
of SCF
Y
0.006
protein_40_YML048W
2 GSF2: ER localized integral membrane protein that may
[FIG]I..[IVL]I
promote secretion of certain
32 hexose transporters, including Gal2p; involved in glucose-dependent repression
Sugar_tr
1.E-02
0.7
Y
0.006
protein_40_YER165W
D..[ERP]E
complex, mediates
32 interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved
RRM_1
1.E-05
tail length,0.7
interactsRNA
with translation
metabolism
factor (1e-09)
eIF-4G
Y
0.006
protein_40_YBR106W
L..[YIM]L
MFS_1
at high inorganic
1.E-08
0.7
Y
0.006
yeast-512_GO-0046907
2 intracellular transport
L[ISD].L[IMF]
32 LLDLL
Clathrin binding motif in AP1
IBN_N
1.E-04
0.8
0.007
oshea_bud_neck
2 oshea_bud_neck
E[DVM]L
32 DLL
Binding motif for clathrin heavy chain ear RhoGAP
1.E-04
0.8
Y
0.006
yeast-413_GO-0005215
SV.[AQW][VTF]
32
Mito_carr
1.E-04
0.9
Y
0.007
protein_40_YLR180W
2 SAM1: S-adenosylmethionine synthetase, catalyzesL[REC]..G[LAS]
of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes
Sam2p)
0.9
0.006
protein_40_YGR252W
[RT]A.L[KW]S
32 H3; GTALL
Receptor
ADA andrecycling
SAGA histone
motifacetyltransferase complexes;
Histone
founding member
1.E-02
0.9
SAGA
N-acetyltransferase
complex (0.001)
superfamily
0.004
yeast-468_GO-0051276
[AG]Q[ANM]Q
32
Helicase_C
1.E-02
1
Y
(1e-24) 0.007
protein_40_YOL133W
VK[SFA]
conjugating enzyme
1 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(1e-05)
of SCF
Y
0.006
protein_40_YLR372W
2 SUR4: Elongase, involved in fatty acid and sphingolipid F..[FSL]A
very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation
MFS_1 of sphingolipid
1.E-03
biosynthesis1
Y
0.006
protein_40_YGL105W
2 ARC1: Protein that binds tRNA and methionyl- and G[GTD]..D[AKL]
32 and
T..D
Gus1p), deliveringFHA1
tRNA to
binding
them, stimulating
motif, Thr catalysis,
must beand
phosphorylated,
ensuring
Pkinase
their localization
binding motif
to1.E-04
theofcytoplasm;
proteins also
binding
1 bindsto
protein
quadruplex
Chk2 kinase
nucleic
activity
acids (0.001)
0.006
protein_40_YER112W
[SQY]I..[NRH]G
either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear
LSMLsm8p complex
1.E-02
part of U6 snRNP
1.1 andU4/U6
possiblyxinvolved
U5 tri-snRNP
in processing
complex
tRNA, snoRNA,
(1e-06)and rRNA
0.006
yeast-980_GO-0051179
2 localization
V.T[LVW]
32
MFS_1
1.E-03
1.2
0.007
yeast-523_GO-0030529
2 ribonucleoprotein complex
[RKA]A..[VDR]A
32 LK[EAD]AE.RA[ET]
TROPOMYOSIN PATTERN
Ribosomal_60s
1.E-04
1.2
0.007
protein_40_YLL008W
D..[DPH]E
Pkinase
particles
1.E-05
1.2
0.006
protein_40_YDR099W
[PRQ]P.[AKR]A
32bindsP..P.[KR]
proteins and DNA,LIG_SH3_2LIG_SH3_2
involved in regulation of many processes including
Pkinase
transport, Ras/MAPK
1.2 signaling, and rapamycin-sensitive signaling
0.005
protein_40_YBR159W
2 IFA38: Microsomal beta-keto-reductase; contains oleateA.F[GVM]
32
MFS_1 high levels
1.E-02
1.2
transporter
phytosphingosine
activity
and medium-chain
(1e-09)
ceramides
Y
0.006
oshea_bud_neck
2 oshea_bud_neck
G.L[KQY]
32 IYG.L
Lck kinase phosphorylation site (peptide screen)
RhoGAP
1.E-03
1.2
bud (1e-47)
Y
0.006
yeast-939_GO-0051234
2 establishment of localization
[ALE]S...A
32
IBN_N
1.E-04
1.3
0.007
yeast-939_GO-0051234
[QGF]L.G[AFM]
32 LFG
Protease Papain substrate, a prototype cysteine
Mito_carr
proteinase 1.E-04
1.3
0.007
yeast-413_GO-0005215
A.[SYL]V
MFS_1
1.E-12
1.4
Y
0.007
protein_40_YPR120C
2 CLB5: B-type cyclin involved in DNA replication during
LK.[EWT][NLS]
to promote initiation of DNA synthesis; functions in formation of mitotic spindles
Pkinase
along with Clb3p 1.E-02
and Clb4p; most1.5
abundant during late G1 phase
0.006
yeast-238_GO-0017111
AR[AVS]
32 [AG]R
Y
ABC_tran
1.E-16
1.6
0.007
yeast-589_GO-0050896
L.D
32 LPDEL
Pkinase
1.7
response to stress (10)
Y
0.006
protein_40_YOL012C
2 HTZ1: Histone variant H2AZ, exchanged for histone H2ADF[GI]LA
32 complex; involved in transcriptional regulation through prevention of thePkinase
1.E-04
1.7
0.004
yeast-649_GO-0003676
[VK].VK
32
RRM_1
1.E-06
2
0.007
protein_40_YGL245W
2 GUS1: Glutamyl-tRNA synthetase (GluRS), forms a KP[ESP][NVA]
synthetase
P[ST]
(Mes1p) and Arc1p;
DNAcomplex
dependent
formation
Protein
increases
kinasethesubstrate
catalytic efficiency
motif
Pkinase
of both tRNA1.E-15
synthetases and
2.1
ensuresprotein
their correct
kinase
localization
activity
to the
(1e-12)
cytoplasm
0.006
10
10
8
10
9
9
8
10
10
7
10
10
8
10
10
10
7
10
9
8
10
10
10
7
9
8
10
10
10
10
10
10
10
9
9
7
10
7
10
10
8
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
8
10
10
9
10
10
9
10
9
10
10
10
10
10
9
9
8
8
10
9
10
10
10
10
10
10
10
9
9
10
10
10
10
10
10
10
10
9
10
8
10
10
10
7
10
10
10
10
10
10
10
10
9
10
10
9
8
9
10
7
10
10
10
9
10
9
10
10
10
10
10
10
10
9
8
10
10
yeast-215_GO-0005694
oshea_bud_neck
protein_40_YGL111W
protein_40_YER012W
protein_40_YNL272C
protein_40_YLR002C
protein_40_YGL245W
matsuyama_nucleolus
protein_40_YDL014W
yeast-1115_GO-0006996
yeast-980_GO-0051179
yeast-856_GO-0009059
yeast-649_GO-0003676
yeast-648_GO-0050791
yeast-596_GO-0044425
yeast-589_GO-0050896
yeast-544_GO-0016070
yeast-521_GO-0051649
yeast-513_GO-0005515
yeast-436_GO-0031323
yeast-410_GO-0007049
yeast-388_GO-0007275
yeast-388_GO-0007275
yeast-388_GO-0007275
yeast-371_GO-0009056
yeast-345_GO-0006396
yeast-341_GO-0045449
yeast-324_GO-0030528
yeast-294_GO-0006366
yeast-267_GO-0000003
yeast-261_GO-0016491
yeast-244_GO-0000279
yeast-235_GO-0009653
yeast-235_GO-0000902
yeast-220_GO-0044255
yeast-219_GO-0046903
yeast-216_GO-0006325
yeast-216_GO-0006323
yeast-215_GO-0007010
yeast-205_GO-0005856
yeast-200_GO-0006519
yeast-1721_GO-0016043
yeast-1433_GO-0006139
yeast-1036_GO-0005739
protein_40_YPR144C
protein_40_YPR144C
protein_40_YPR119W
protein_40_YPR119W
protein_40_YPR110C
protein_40_YPR110C
protein_40_YPR016C
protein_40_YPL256C
protein_40_YPL220W
protein_40_YPL209C
protein_40_YPL204W
protein_40_YPL204W
protein_40_YPL204W
protein_40_YPL153C
protein_40_YPL153C
protein_40_YPL153C
protein_40_YPL153C
protein_40_YPL153C
protein_40_YPL153C
protein_40_YPL146C
protein_40_YPL141C
protein_40_YOR326W
protein_40_YOR181W
protein_40_YOR133W
protein_40_YOR096W
protein_40_YOL086C
protein_40_YOL041C
protein_40_YOL013C
protein_40_YNL307C
protein_40_YNL289W
protein_40_YNL154C
protein_40_YNL118C
protein_40_YNL118C
protein_40_YNL118C
protein_40_YMR304W
protein_40_YMR216C
protein_40_YMR194W
protein_40_YMR106C
protein_40_YML085C
protein_40_YML073C
protein_40_YML007W
protein_40_YML007W
protein_40_YLR372W
protein_40_YLR249W
protein_40_YLR180W
protein_40_YLR180W
protein_40_YLR166C
protein_40_YLR166C
protein_40_YLR129W
protein_40_YLR002C
protein_40_YKR001C
protein_40_YKR001C
protein_40_YKL180W
protein_40_YKL104C
protein_40_YKL104C
protein_40_YJR059W
protein_40_YJR059W
protein_40_YJL177W
protein_40_YJL177W
protein_40_YJL092W
protein_40_YJL081C
protein_40_YJL074C
protein_40_YJL074C
protein_40_YJL033W
protein_40_YIL095W
protein_40_YIL061C
protein_40_YIL019W
protein_40_YHR196W
protein_40_YHR121W
protein_40_YHR082C
protein_40_YHR041C
protein_40_YHL007C
protein_40_YHL007C
protein_40_YGR275W
protein_40_YGR218W
protein_40_YGR218W
protein_40_YGR218W
protein_40_YGR092W
protein_40_YGR074W
protein_40_YGL180W
protein_40_YGL179C
protein_40_YFL039C
protein_40_YFL037W
protein_40_YFL037W
protein_40_YFL002C
protein_40_YFL002C
protein_40_YER177W
protein_40_YER177W
protein_40_YER172C
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
HMG_box
1.E-02
2.4
chromosome (1e-43)
PH
1.E-03
2.6
bud (1e-25)
Y
DEAD
1.E-03
3.1
nucleolus (0.001)
Y
PCI
1.E-03
3.2
SEC2: Guanyl-nucleotide exchange factor for the small Y.[ASK]P
32cytoplasmic
E.Y.[QSG]
vesicles; essential
Protease
for post-Golgi
TEVProtease
vesicleTEV
transportY
Pkinase
1.E-24
3.5
Y
T[PVD][GF]R
32precursors
[AG]Rto mediate their
Protease
intranuclear
matriptase
transport;
protease
also bindssite
to chromatin toDEAD
3.5
ribosomal
large subunit
initiationassembly and maintenance (1e-08)
GUS1: Glutamyl-tRNA synthetase (GluRS), forms aFG.[ACN][KAR]
synthetase
FGRA
(Mes1p) and Arc1p;
DNAcomplex
bindingformation
motif in increases
ssDNA binding
the catalytic
proteins
efficiency
Pkinase
of both tRNA1.E-13
synthetases and
3.8
ensuresprotein
their correct
kinase
localization
activity
to the
(1e-13)
cytoplasm
matsuyama_nucleolus
[PNL]TRE[LR]
32 RE..E
DEAD
1.E-11
4.1
[DHN]V..R[GAY]
32 is required for processing of pre-18S rRNA; has similarity to mammalian
Helicase_C
fibrillarin
1.E-03
4.7
nucleolus (1e-12)
V[RKE].W[DI]
32
WD40
1.E-20
5.4
localization
[AEG]F[SMT]FG
32 F..F[ST][FY]
Rsks are phosphorylated at this bulky ring site, Ser/Thr must be phosphorylated. This
rRNA
motif
export
recruits
from
PDK1
nucleus
kinase(1e-14)
K[MFY][SVQ]KS
32 F..KY[DE]KSL Nucletodie binding motif in Annexin
Y 6 for ATP/GTP
[AEN]D.[DAK]E
32 D.D
Y
S[STA].[RDW]LE
32 S[ST]
membrane part
S[FIT]..Y[LVT]
32 Y[VLTFIC]
LIG_SH2_STAT5
T..K[NLH]
32 TP.K
CDK5 kinase substrate motif
RNA metabolism
S[SQV].S[TPY]
32 S[ST]
establishment of cellular localization
Q.[LQF]S
32
Y
protein binding
KL.[QAN][FNI]
32 NKLY
LIM3 domain in enigma binds toYthis site in Ret
[KQC]P..IK[KTA]
32
cell cycle
K.T[NIR]
32 RKK.[ST]
cell cycle (1e-16)
development
[TSN]H[KQL]K
32
development
G[AMG][NKL]S
32
Y
development
TT[KGT][IHM]
32 YTT[ILM]
Syk N-terminal SH2 domain binding motif
Y
catabolism
K[KMW]..K[SRI]
32 KR
CLV_PCSK_PC1ET2_1
RNA processing
[NAL]D..[SM]ES
32 RSESEE
14-3-3 binding motif in inositol polyphosphate
Y
5-phosphatase
[LDA]S[QDV]H
32 [PLIM].[LIDE]SQATM kinase substrate motif
KA..L[SYM][VQT]
32
K[IRD].S[EDP]
32 [DE]S[DE].[DE] Casein Kinase II substrate motif
reproduction
S[DLQ]E[DAG]
32 LSQE
KR[KIR]
32 KR
CLV_PCSK_PC1ET2_1
M phase
K.Q
M phase (1e-28)
morphogenesis
Q[DTL][AQT]S
32
Q[DTL][AQT]S
32
cellular lipid metabolism
L..[HFC]F
32
secretion
[KGR]LI[TQW]
32
secretion (1e-47)
ND.E[LEK][SRY]
32 D.E
Sec24pSec24pSec24p
chromatin modification (1e-12)
DNA packaging
ND.E[LEK][SRY]
32 D.E
Sec24pSec24pSec24p
chromatin modification (1e-12)
P.[PNI]R
32 P..R..KP
SH3 binding motif for GRB2 C-term
cytoskeleton
[LNC][NFC]LND
32
[AHV]E..G[LAC]
32
R.N[VEP]
32
Y
nucleobase, nucleoside, nucleotide and nucleic acid [REK]D.[NEH]T
metabolism
32 D.E
Sec24pSec24pSec24p
Y
mitochondrion
IR[TAP][LSV]
32 RPL
VEGFR and neuropilin binding peptide
nucleoside-triphosphatase activity (0.01)
DIS[DY][DF]
Y
EE.[ERA][KFE]
and nuclear
EEDexport of 40S ribosomal
Ankyrin B
subunits
C-terminal motif that binds
Y internal Ankyrin repeats
Y
[GSE]D.T[FYA]
32the transition
D.D.[TV]
from G2 to M
Motif
phase;
in PRS1
accumulates
and PRS-2
during G2
required
and M,for
then
phosphatase
targeted via aactivity
destruction
andbox
saltmotif
stress
for ubiquitin-mediated
response
bud neck
degradation
(0.001)by the proteasome
Y
R[GYM].P[RNA]
32the transition from G2 to M phase; accumulates during G2 andYM, then targeted via a destruction box motif for ubiquitin-mediated
cell cycle
degradation
(0.01) by the proteasome
Y
RPC40: RNA polymerase subunit, common to RNA HG[VRN][ALD]
32
Y
RPC40: RNA polymerase subunit, common to RNA polymerase
R.[LYK]G
I and III
RNA polymerase complex (0.01)
Y
TIF6: Constituent of 66S pre-ribosomal particles, has similarity
E.[KER]A
32initiation
LK[EAD]AE.RA[ET]
TROPOMYOSIN
be involved in the
PATTERN
biogenesis and or stability of 60S ribosomal subunits
CLN2: G1 cyclin involved in regulation of the cell cycle;
LI..G[LS][VY]
activates Cdc28p kinase to32
promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
[GTV]K[KYN]V
32 nearly
G[VT][EK][FY]VCCP
identical to Rpl1Bp
A4_EXTRA
and has PATTERN
similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation
ribonucleoprotein
is lethal
complex (1e-05)
F[EAC]..[EGD]G
attachments; helps
Y
[NRY]SN[NLT]G
32 SNHG[AG]RQ
FMN_HYDROXY_ACID_DH_1
segregation; binds the CTD
PATTERN
DE..E[EKS][VNF]
32
DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
HRR25: Protein kinase involved in regulating diverse events
G[KEY]..A
including vesicular trafficking,
32
DNA repair, and chromosome segregation; binds the CTD
Y of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
RAD53: Protein kinase, required for cell-cycle arrest[IEQ]H..G[SEY]
RAD53: Protein kinase, required for cell-cycle arrest [KRI]K[APY]P
activated
K[ST]P.K
GSK-3, ERK1,
whenERK2,
interacting
CDK5
withsubstrate
hyperphosphorylated
motif
A..[LSD]N
to DNA damage; 32
Y
RAD53: Protein kinase, required for cell-cycle arrestPL.[DVP][FPY]
activated
PPLP
LIG_WW_2LIG_WW_2
Y
RAD53: Protein kinase, required for cell-cycle arrestS[AHY]P[NYE]
activated
P[TS]AP
LIG_PTAPLIG_PTAP
RAD53: Protein kinase, required for cell-cycle arrest inTI[NIS][NTV]
Y
NOP53: Nucleolar protein; involved in biogenesis ofK[KQV].K[SFN]
32 interacts
K[KR].[KR]
Nuclearfactors
localization
Cbf5p and
motif
Nop2p; null mutant is viable but growth is severely impaired
FRK1: Putative protein kinase; similar to Kin4p; green
E[NDV]..D[DAY]
32 protein localizes to the cytoplasm; YPL141C is not an essential
Y gene
MYO2: One of two type V myosin motors (along with
[GHN]E.[GRM]V
Y
IV.[HRY][KVT]
Y patches; homolog of the human Wiskott-Aldrich syndrome
endocytosis
protein (WASP)
(0.001)
[SL]D..[PV]KE
32
during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
Y
G[KRM]K[VGM]
32Rps7Bp;
G[KR][KR]
interacts with Kti11p;
Amidation
deletionafter
causes
cleavage
hypersensitivity
after Gly
to (must
zymocin;
behas
in secretory
similarity topathway)
rat S7 and Xenopus S8 ribosomal
ribonucleoprotein
proteins
complex (1e-11)
Y
ADH1: Alcohol dehydrogenase, fermentative isozyme[DIY]A.D[TIG]
32
Y
NOP12: Nucleolar protein, required for pre-25S rRNAAF[TV][KTQ]
32recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe
nucleolus (1e-04)
HRD1: Ubiquitin-protein ligase required for endoplasmicA..[LEY]G
32
carboxylic
with Hrd3p;
acid
contains
metabolism
an H2 ring
(1e-04)
finger
[STF]P..[SAQ]P
32of chromosome
[ST]P segregation
LIG_WW_4LIG_WW_4
and in regulating entry into meiosis;
Y related to mammalian glycogen synthase kinases of the GSK-3 family
PCL1: Pho85 cyclin of the Pcl1,2-like subfamily, involvedTP[RAN]
32cycleLTP
RAF1 kinase localizes
substrate
to motif
sites of polarized
Y
cell growth
YCK2: Palmitoylated, plasma membrane-bound casein A..P[PKE]
32
Y
[DNV]P.I[SWK]
32 PWI
the 5' cap structureMotif
from mRNAs
in SRM160
prior to
fortheir
binding
degradation;
DNA and
member
RNAof the Nudix hydrolase family
LV..[QL][TC]L
32
QQ.[QND][NGS]
32 Q[MLVI]DG..[DE]
the 5' cap structureCLV_TASPASE1
from mRNAs prior to their degradation; member of the Nudix hydrolase family
Y
[TPL][DHT]PF
32 DPF
AP2 binding motif in Synaptojanin 1 and EPS15
SKY1: SR protein kinase (SRPK) involved in regulating proteins
P.[ESR]E
involved in mRNA32
metabolism
[DE]FPPPP.[DE][DE]
and cation homeostasis;
EVH1 binding
similarsite
to human
in ActA
SRPK1
proteinYof Listeria monocytogenes
helicase activity (0.01)
Y
S.L[FST]
32
nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YKU80: Subunit of the telomeric Ku complex (Yku70p-Yku80p),
A[SAN]..[KIR]P
involved in telomere
32length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
[ADC]P.[IEL]A
32 polymerizes
P.L
Y
R.[AHK]R
32 has
R.[RK]R
CLV_PCSK_FUR_1
Y
GN.[NTS][NKF]
tolerance;
N.[TS]
activated by H2O2
N-linked
throughglycosylation
the multistep formation
site
of disulfide bonds and transit from the cytoplasm to the nucleus;
general
mediates
RNA
resistance
polymerase
to cadmium
SN[APG][NRE]
general
mediates
RNA
resistance
polymerase
to cadmium
I[AIV][ILMV]Y
very long
[ILV][ILV][IFV]Y[TV][IL][ILVP]
chain 20-26-carbon
SH2
fatty
ligand
acids for
fromSHP-2N
C18-CoA(PTP11n)(Tyr
primers; involved
must
in regulation
be phosphorylated)
of sphingolipid biosynthesis
YEF3: Translational elongation factor 3, stimulates the binding
E[VYG]K
of aminoacyl-tRNA 32
(AA-tRNA)
[QGF][WLCF]GDE[GA]K[GA]
to ribosomes byADENYLOSUCCIN_SYN_1
releasing EF-1 alpha from the ribosomal
PATTERN
Y complex; contains two ABC cassettes; binds and hydrolyses ATP
GK[TPG]
of ATP[GA]....GK[ST]
Purine
methionine;
nucleotide
one of triphosphate
two differentially
binding
regulated
motif
isozymes (Sam1p and Sam2p)
cytosol (0.01)
R.[TAE]V
of ATPR.[ST]
PKA
methionine;
consensus
one of
phosphorylation
two differentially regulated
site
isozymes (Sam1p and Sam2p)
Y
SEC10: Essential 100kDa subunit of the exocyst complex
[GVC]R..[ETN]D
Sec8p, R..[PA]DG
Sec10p, Sec15p, Exo70p,
LIG_TNKBMLIG_TNKBM
and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
E[SRC]F[ERG]
Sec8p, EEEYF
Sec10p, Sec15p, Exo70p,
EGFRand
kinase
Exo84p),
phosphorylation
which has the site
essential
(peptide
function
screen)
of mediating polarized targeting of secretory
exocyst
vesicles(0.01)
to active sites of exocytosis
DIP2: Nucleolar protein, specifically associated with GV..[TIH][KLM]
32 ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the
rRNA
activeprocessing
pre-rRNA processing
(1e-15)complex
[KPV]K..[KSM]K
32precursors
K..[ST]
to mediate their
PKA
intranuclear
kinase substrate
transport; motif
also binds to
Y chromatin to promote the association of DNA replication cytoplasm
organization
VPS1: Dynamin-like GTPase required for vacuolar [GN]L..N[VWK]V
32 PN[VA]V[AM]P[LP]
organization, late
SMAD-interacting
Golgi-retention of some
motifproteins,
-FM2 inregulating
motif forperoxisome
binding in biogenesis
XFoxH1
K[VFG].[KHS]Q
32 [ST]Q
organization, late
ATM
Golgi-retention
of some proteins,
site
regulating peroxisome biogenesis
establishment and/or maintenance of chromatin architecture (0.001)
K..[AKR]A
to Rpl17Bp
K[KR].[KR]
and has similarity
Nuclear
to E. coli
localization
L22 and ratmotif
L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
Y
[VDS]E..P[KA]
of glucosamine-6-P
[ST]E
and glutamate
G protein-coupled
from fructose-6-P
receptor
and glutamine
kinase 1insubstrate
the first step
motif
of chitin biosynthesis
V..[AYN]G
of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis
Y
PTK2: Putative serine/threonine protein kinase involvedEQ[QAR]
32across
[DE][DE][FL][FL][DE][LM][IL]...Q[GS].R[LM][DE][DE]QR
plasma membrane;
GoLoco
enhances
motif,
spermine
a G alpha
uptakebinding motif
PTK2: Putative serine/threonine protein kinase involvedS..P[TSK]
32across
P[ST]
plasma membrane;
DNA
enhances
dependent
spermine
Protein
uptake
kinase substrate motif
L..[SFD]I
to Rpl17Ap
L...I...[IL]
and has similarity
Corepressor
to E. coli L22nuclear
and rat L17
boxribosomal
motif binds
proteins
to nuclear receptors
N..[LNM]L
Q[EFP]S
for proper
QPS..E
Phosphorylation
motif in alpha
and transition
3A, alphafrom
6A,Meiosis
alpha I7A
to II;
Integrin
affects tails
genome stability by suppressing unscheduled homologous recombination
E[EI].[LD]RI
A[NDE]T[ERA]
32
Y
SMC3: Subunit of the multiprotein cohesin complexV[NKT]..[GFH]G
32
Y
HCA4: Putative nucleolar DEAD box RNA helicase; high-copy
E..A[AEG]
number suppression32
of a U14
LK[EAD]AE.RA[ET]
snoRNA processing
TROPOMYOSIN
mutant suggestsPATTERN
an involvement in 18S rRNA synthesis
mRNA polyadenylylation (1e-07)
Y
PRK1: Protein serine/threonine kinase; regulates the[SQN]PA[QVI]
32 actin[ST]P
LIG_WW_4LIG_WW_4
the phosphorylation of the Pan1p-Sla1p-End3p protein complex
actin cortical patch assembly (0.01)
SNP1: Component of U1 snRNP required for mRNA splicing
EA.[DIV][ATI]
via spliceosome; may32
interact
IEAD
Protease
to regulate
Caspase
polyadenylation;
10
homolog of human U1 70K protein
U2-dependent spliceosome (1e-08)
FAF1: Protein required for pre-rRNA processing and[AQE]DG[VGY]
32
Y
nucleolus (1e-13)
E[ADW].[DMV]I
nucleolus (1e-06)
LSM12: Protein of unknown function that may function
HE..[IRS][KQC]
in RNA processing; interacts
32with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS
S.[ADY]D
32 overproduction
S.D
causes CAMKII
allele-specific
phosphorylation
suppression ofsite
the prp20-10 mutation
TL.[LH][ESF]S
32
S..[TND]N
32in pheromone
S..[ST] response and
Casein
Kinase I consensus
growth
phosphorylation
pathways, activated
site by
(N-term
Cdc42p;
Ser
binds
must
Ste4p
firstatbe
a GBB
phosphorylated)
motif bud
present
(0.001)
S.[PLD]K
32in pheromone
S.D
response and
CAMKII
phosphorylationgrowth
site pathways, activated by Cdc42p; binds Ste4p at a GBB motif regulation
present in noncatalytic
of conjugation
domains with
of PAK
cellular
kinases fusion (0.01)
RTT102: Component of both the SWI/SNF and RSCNS..K[RA][AK]
32 suggested
KR
role in chromosome
CLV_PCSK_PC1ET2_1
maintenance; possible weak regulator of Ty1 transposition
EE..[QKS][TAS]
32 from
EED
the nucleus
cellular localization (0.01)
CRM1: Major karyopherin, involved in export of proteins,EL[EPW]
32 from
S[LW]LD[DE]EL[LM]
the nucleus
Y
G[TNK]A[NLA]
32 from the nucleus
DBF2: Ser/Thr kinase involved in transcription and [LNK]E.E[DMY]E
stress response; functions as part
32 of aSEDEE
network of genes inCKII
exit from
kinase
mitosis;
phosphorylation
localization is cell
sitecycle
(peptide
regulated;
screen)
activated by Cdc15p during the exit from mitosis
SMD1: Core Sm protein Sm D1; part of heteroheptameric
IF[ITA][RQ]
32
Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human
small
Sm D1
nuclear ribonucleoprotein complex (1e-13)
ATG1: Protein serine/threonine kinase, required for vesicle
R[PA][PDG]P
32 and
PPPGHRPPPGHR
SH3 binding
targeting
motif(Cvt)CD2
pathway;
and structurally
Sm B/B' motif
required
in C-terminus
for pre-autophagosome
(potential Class
formation;
2 SH3
forms
motif)
a complex with Atg13p and Atg17p
[PKT][SKW].RA
for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
A[AKQ][LKF]R
32and has
[KR]R
CLV_PCSK_KEX2_1
L2 and rat L8 ribosomal proteins
KR[RP][TMP]
cytoskeletal
KR functions
CLV_PCSK_PC1ET2_1
actin cortical patch (0.01)
[GVE][SQI].PD
32dimer,
LPDEL
which polymerizesMotif
to form
in microtubules
CBP for interaction with PPARg-LBD (secondary site)
K[SPA].D[PRM]
32dimer,
S.D
which polymerizesCAMKII
Y
Y
KK.[SAE][KFW]
32 of 60S
RKK.[ST]
ribosomal subunits
ZIPatkinase
a late step
phosphorylation
in the pathway;motif
sediments with 66S pre-ribosomes in sucrose gradients
P[NV].[GR]KS
32 of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
[INQ]D.N[SGM]
Y
P[TAY].A[KGY]
32bindsP[ST]
proteins and DNA,DNA
involved
dependent
in regulation
Protein
of many
kinase
processes
substrate
Y including
motif
exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
BRR2: RNA-dependent ATPase RNA helicase (DEIH
[EGH][AVP].HK
spliceosome (1e-09)
Y
chromosome
oshea_bud_neck
[IED]I..K[NWM]
R[RSE]..L[EIS]
32
32
R..L
GK.[AS]A[FK]
32biogenesis
[EY]A..N[AHR]
the cell cycle
LIG_APCC_Dbox_1
0.007
0.007
0.004
0.005
0.006
0.004
0.006
0.006
0.006
0.007
0.007
0.007
0.007
0.007
0.007
0.007
0.007
0.007
0.007
0.006
0.007
0.007
0.007
0.007
0.007
0.006
0.007
0.006
0.007
0.007
0.007
0.007
0.007
0.007
0.007
0.007
0.006
0.006
0.007
0.005
0.007
0.007
0.007
0.007
0.004
0.006
0.006
0.006
0.005
0.006
0.006
0.004
0.006
0.005
0.004
0.005
0.006
0.005
0.006
0.006
0.006
0.007
0.006
0.006
0.006
0.004
0.005
0.004
0.007
0.006
0.005
0.006
0.006
0.006
0.006
0.006
0.004
0.006
0.005
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.005
0.006
0.005
0.006
0.004
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.004
0.005
0.005
0.006
0.005
0.007
0.005
0.006
0.004
0.006
0.004
0.006
0.006
0.004
0.006
0.006
0.006
0.005
0.004
0.006
0.006
0.007
0.006
0.005
0.005
0.006
0.004
0.006
0.005
0.005
10
9
7
8
9
7
9
10
10
9
9
10
9
10
9
10
10
10
10
9
10
10
10
10
10
8
10
10
10
10
10
10
10
10
10
10
9
9
10
7
10
10
10
10
8
10
10
10
8
9
10
7
9
10
7
8
10
9
9
9
10
10
10
10
10
9
10
7
10
10
9
10
10
10
10
10
9
10
8
10
10
10
10
9
10
10
10
10
10
9
10
10
9
10
7
10
10
10
10
10
10
10
10
10
7
10
10
9
10
9
9
10
9
10
7
10
10
9
10
10
9
7
8
8
10
10
9
10
9
10
7
9
10
9
protein_40_YER133W
protein_40_YER102W
protein_40_YER102W
protein_40_YER025W
protein_40_YDR510W
protein_40_YDR447C
protein_40_YDR388W
protein_40_YDR356W
protein_40_YDR303C
protein_40_YDR174W
protein_40_YDR167W
protein_40_YDR064W
protein_40_YDL148C
protein_40_YDL136W
protein_40_YDL055C
protein_40_YDL055C
protein_40_YDL029W
protein_40_YCR086W
protein_40_YCL059C
protein_40_YBR189W
protein_40_YBR031W
protein_40_YBR009C
protein_40_YBL026W
protein_40_YBL016W
protein_40_YAR007C
protein_40_YAL032C
oshea_vacuole
oshea_vacuole
oshea_spindle_pole
matsuyama_ER
matsuyama_ER
genetic_YNL153C
genetic_YNL153C
genetic_YNL153C
genetic_YNL153C
genetic_YLR262C
genetic_YLR200W
genetic_YGL020C
genetic_YGL020C
genetic_YDL020C
genetic_YAL024C
genetic_YAL024C
genetic_YAL024C
protein_40_YER165W
matsuyama_Cytoplasmic_dots
yeast-217_GO-0007046
yeast-939_GO-0051234
protein_40_YLR186W
matsuyama_Golgi
protein_40_YML010W
protein_40_YML085C
protein_40_YLR340W
yeast-752_GO-0016787
yeast-661_GO-0050789
yeast-648_GO-0050791
yeast-460_GO-0006351
yeast-294_GO-0006366
yeast-216_GO-0006325
yeast-216_GO-0006323
yeast-1464_GO-0019538
protein_40_YPL126W
protein_40_YOL133W
protein_40_YJL095W
yeast-512_GO-0046907
yeast-256_GO-0016462
protein_40_YJL092W
yeast-213_GO-0009719
protein_40_YPL129W
protein_40_YML010W
protein_40_YLL008W
protein_40_YGL120C
protein_40_YDL013W
protein_40_YPL031C
yeast-256_GO-0016462
protein_40_YMR093W
protein_40_YHR148W
yeast-215_GO-0005694
yeast-1493_GO-0043234
protein_40_YMR117C
protein_40_YGR128C
yeast-222_GO-0009308
protein_40_YBL004W
yeast-213_GO-0009719
yeast-1974_GO-0005634
protein_40_YMR117C
protein_40_YJL109C
yeast-222_GO-0009308
yeast-513_GO-0005515
protein_40_YML048W
protein_40_YER165W
matsuyama_Cytosol
yeast-235_GO-0000278
yeast-238_GO-0017111
protein_40_YPL240C
protein_40_YJL130C
yeast-205_GO-0005856
protein_40_YLR026C
yeast-610_GO-0031090
yeast-335_GO-0016772
protein_40_YMR128W
protein_40_YER012W
yeast-256_GO-0016462
yeast-240_GO-0006807
matsuyama_Nucleus
genetic_YPL240C
yeast-335_GO-0016772
yeast-1721_GO-0016043
protein_40_YGL105W
protein_40_YDR510W
yeast-685_GO-0016740
genetic_YLR200W
yeast-752_GO-0016787
protein_40_YJR145C
protein_40_YGL245W
protein_40_YJL010C
protein_40_YNL272C
protein_40_YDL013W
matsuyama_periphery
yeast-410_GO-0007049
protein_40_YDR328C
protein_40_YNL175C
yeast-1974_GO-0005634
protein_40_YKL021C
oshea_cytoplasm
yeast-706_GO-0043412
matsuyama_nucleolus
yeast-238_GO-0017111
yeast-942_GO-0043232
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
VD.[PEA][EFS]
32manyHAVDI
processes includingN-Cadherin
glycogen metabolism,
ligand sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly
phosphatase
isolated
regulator
with Sds22p
activity
0.006
0.006
0.007
0.004
PS[GKQ]
32 proteins;
QPS..E
regulates chromatid
Phosphorylation
cohesion, chromosome
motif in alpha
segregation,
3A, alphaAPC-mediated
6A, alpha 7A
proteolysis,
Integrin tails
DNA replication and septin ring dynamics
0.006
RPS17B: Ribosomal protein 51 (rp51) of the small (40s)
G[KMI]K[VAG]
Y
0.006
RVS167: Actin-associated protein, subunit of a complexR..[KGY]V
32 in regulation
R..K of actin cytoskeleton,
SH3 binding
endocytosis,
motif for and
GADS
viability
SH3following
recognizing
starvation
slp-76
or osmotic
motif (nonconventional)
stress; homolog of mammalian amphiphysin
0.006
R[RDI].I[PQE]
32 involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated bystructural
Mps1p in cell
constituent
cycle-dependent
of cytoskeleton
manner
(1e-07)
0.006
PA..[SDQ][FCV]
RSCtocomplex
Rsc30p (1e-05)
0.004
[EKS]A..K[RWL]
32genome
KRmaintenance; rDNA-binding
CLV_PCSK_PC1ET2_1
component of the Pol I transcription
Y
system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
Y
0.006
QI.[QHI][QNI]
Y
0.005
[KYH][LIN]RA
32coli S15
Y[LIVAC]R[VA]S[ST]..Q
RECOMBINASES_1
proteins
PATTERN
0.006
[EI]E[PLS]S
32 nuclear
Y[MLE]EP
SH2 ligand
subunits;
for Vav1
also (Tyr
present
must
in the
besmall
phosphorylated)
subunit processome complex, which is required for rRNA
processing
processing
of pre-18S (1e-16)
rRNA
0.006
[RK]A.[KTF]V
32 and has similarity to rat L35 ribosomal protein
0.005
E.[ATR]F
guanyltransferase),
Y
0.006
RP[DEG]
guanyltransferase),
32 synthesizes
P.RP.[RH][RH]
GDP-mannose
SH3 from
binding
GTPmotif
for amphiphysin-general
Y
0.006
ARP2: Essential component of the Arp2/3 complex, [QYD]I.Q[VQY]
0.005
CSM1: Nucleolar protein that forms a complex with G[PKQ].G[VSN]
32 GP during meiosis Protease
I to mediateTTP
accurate
cleavage
chromosome
site
segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
Y
0.006
AR[IGE]
32 assembly
[AG]R
of 40S ribosomal
Protease
subunit matriptase protease site
nucleolus (1e-29)
0.006
[ARG]K..[AKF]A
subunit; nearly identical to
32Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins
0.006
RPL4A: N-terminally acetylated protein component [LAK]G.K[AVM]
32 nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins
0.006
HHF1: One of two identical histone H4 proteins (seeL[GPV]..[LKS]D
Y
0.006
V[QP]..L[LRT]S
either VP
Interleukin
Lsm1p
converting
complex involved
enzyme
in mRNA
protease
decay; nuclear Lsm8p complex part of U6 snRNP andsnRNP
possibly U5
involved
(0.001)
in processing tRNA, snoRNA, and rRNA
0.004
FUS3: Mitogen-activated serine/threonine protein kinaseE.[EFD]D
32 Y.E.Eby Ste7p; substrates
Src phosphorylation
include Ste12p, Far1p,
site Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating
regulation
Tec1p,of
promoting
conjugation
its degradation
with cellular fusion (1e-04)
0.006
RFA1: Subunit of heterotrimeric Replication Protein A (RPA),
A[VPE]K
response to DNA damage stimulus (0.001)
0.006
[NDC]IG[KMH]
32 interacts
EFYA.[VI]G[RKH]S
SHP2Prp22p
phosphatase
and Prp46p;
substrate
orthologous
motif
Y
0.005
oshea_vacuole
I..[FLH]I
32
vacuole (1e-25)
0.006
oshea_vacuole
L..[AGW]S
32
vacuole (1e-31)
0.006
oshea_spindle_pole
N[EML]..[ED]L
32
0.007
KE.[KAC][ILK]
32 KEN
LIG_APCC_KENbox_2
Y
0.007
S[TAY]S
32 R.S.S.P
14-3-3 binding motifs, Ser must be phosphorylated
Y
0.006
[GPN]I.Q[ENP]
32
Y
0.007
[RAP]KP[SPY]
32 KP..[QK]
LIG_SH3_4LIG_SH3_4
0.007
N..[DVW]R
32
0.007
N.[TQD]D
32 N.[TS]
Y
0.008
matsuyama_ER
[SIM]Y.V[FAV]
32 YTV
14-3-3 domain binding motif
Y
Y
0.008
matsuyama_ER
W..[GFC]T
32 W..[WFY]
AP1 binding site for endosomal trafficking
endoplasmic reticulum membrane (1e-08)
Y
0.008
GIM3: Subunit of the heterohexameric cochaperone [SEL][LPG].ERI
cell cortex (0.01)
Y
0.005
GIM3: Subunit of the heterohexameric cochaperone QE..[RSP][SNI]
establishment of cell polarity (sensu Fungi) (0.01)
Y
0.006
GIM3: Subunit of the heterohexameric cochaperone
S[ERN]..SL[EMH]
specifically
[ST]R..S
GSK3-BETA
and transfers
phosphorylation
target proteins
siteto it
Y
0.005
Y..[LED]Q
specifically
[DN].Y..[DE]
cCBl TKB
anddomain
transfersbinding
target proteins
motif, Tyr
to it must be PO4
mitotic cell cycle (0.001)
0.006
YPT6: GTPase, Ras-like GTP binding protein involved inP.[KNY]K
32 for
[ST]P.[KR]
Cyclin D1/CDK1,2,4,5
vesicles with the
phosphorylation
late Golgi, maturation
site of the vacuolar carboxypeptidase Y; has similarity
DNAtometabolism
the human GTPase,
(1e-09)
Rab6
Y
0.006
YKE2: Subunit of the heterohexameric Gim/prefoldinT[VHE].[LMG]M
Y
0.006
GET1: Subunit of the GET complex; required for the retrieval
L.[LDI]I
32the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
Y
(1e-10) 0.006
GET1: Subunit of the GET complex; required for theL[ETK]..[RSP]K
retrieval of HDEL proteins from
RPN4: Transcription factor that stimulates expression[NLC]L.[EHV]E
levels S[LW]LD[DE]EL[LM]
are in turn regulatedTRG_LysEnd_GGAAcLL_2
by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated
chromosome
by various
organization
stress responses
and biogenesis (sensu Eukaryota) (0.001) 0.006
K..[ADR]S
32 acts
KR.RS
ZIP kinase
exchange
substrate
factor (GEF)
motif for Tem1p,
Y which is a key regulator of mitotic exit; physically associates
telomere
with Ras2p-GTP
0.006
LTE1: Putative GDP/GTP exchange factor required for mitoticKL
32 acts
NKLY
LIM3 domain
exchangeinfactor
enigma
(GEF)
binds
for Tem1p,
to thiswhich
site inis Ret
a key regulator of mitotic exit; physically associates
chromosome
with Ras2p-GTP
organization and biogenesis (sensu Eukaryota) (1e-19) 0.006
V.N[DKA]
32 acts as a guanine nucleotide exchange factor (GEF) for Tem1p,
Y which is a key regulator of mitotic exit; physically associates
cell cycle
with Ras2p-GTP
(1e-09)
Y
0.006
G.[PRT]G
complex, mediates
31 interactions
IQ.RG.RG.RRR
between theBinding
5' cap structure
motif on
and
Calmodulin
the 3' mRNA poly(A) tail, involved
RRM_1
1.E-03
tail length,-4.1
interactsRNA
with translation
metabolism
factor (1e-09)
eIF-4G
Y
0.006
P.[SPM]S
31 P.P
motif in interleukin 5 receptor necessary for SH3_1
signaling
1.E-03
-2.1
0.007
ribosome biogenesis
[ASF]R..D[IVA]
31 [AG]R
DEAD
1.E-11
-1.9
Y
0.007
G.[ALM]S
31 GP[QM]SPI
JNK1 Kinase substrate motif
Mito_carr
1.E-06
-1.6
Y
0.006
[KAG]K..K[RHL]
production;
KR associated withCLV_PCSK_PC1ET2_1
spindle/microtubules; nuclear localization dependsWD40
1.E-02
with Nop14p;
-1.3
may bind
rRNA
snoRNAs
processing (1e-21)
0.006
matsuyama_Golgi
VL[IFL]
31 E.IYGVLF
Lck kinase substrate motif
zf-DHHC
1.E-03
-1.3
Y
0.008
SPT5: Protein that forms a complex with Spt4p and EA.[TVA][PKS]
31 IEAD
Protease
Spt4p-Spt5p
Caspase complex
10
also plays a role in DEAD
pre-mRNA processing
1.E-02
-1.2
0.006
E.I[GSH]
31 polymerizes
YE.[IV] to form microtubules
HEAT
1.E-02
-1.1
microtubule (0.01)
Y
0.006
[RGW]R.A[RCY]
31 shown
GR.A
to be phosphorylated
Protease
on serine
tPA proteolytic
302
site
DEAD
1.E-02
-1.1
0.006
hydrolase activity
H..P
31 QHR.P[PL]PP[GS]H[RH]
Motif recognized by GYF domains
UCH
1.E-04
-1
0.006
HT.[EHR]K[PLI]
31
zf-C2H2
1.E-11
-1
Y
0.007
HT.[EHR]K[PLI]
31
zf-C2H2
1.E-11
-1
Y
0.007
E..L[LEQ]
31 [DE]..LL
Di-Leu acidic motif for receptor endocytosisZn_clus
(recognized by VHS
1.E-06
domain of-0.9
GGA proteins)
0.006
T[GFT]E[KDI]P
31 [ST]E
zf-C2H2
motif
1.E-06
-0.9
0.005
PS[TNV][KGV]
31 P[ST]
Bromodomain
motif
1.E-02
-0.9
Y (1e-51) 0.007
DNA packaging
PS[TNV][KGV]
31 P[ST]
Bromodomain
motif
1.E-02
-0.9
Y (1e-51) 0.007
protein metabolism
S[FEH].S[SHA]
31 S[ST]
Zn_clus
1.E-02
-0.9
0.006
NAN1: U3 snoRNP protein, component of the small[WEY]D..S[GKE]
31 D..SII.FF
CK I delta
required
kinase
forphosphorylation
the biogenesis of18S
siterRNA
(peptide
WD40
screen)
1.E-05
-0.9
0.006
I.E[FTQ]
31(SCF);
IYE
required for Gic2p,cFPS/FES
Far1p, Sic1p
kinase
and Cln2p
phosphorylation
degradation; may
sitetether
(peptide
Cdc34p
F-box
screen)
(a ubiquitin1.E-11
conjugating enzyme
-0.9 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(1e-09)
of SCF
Y
0.006
P[VPI]..S[QSK]
kinase S[ST]
C signaling pathway,MDC1
which controls
BRCT domain
cell integrity;
binding
uponmotif
activation by Pkc1p
Pkinase
phosphorylates1.E-02
downstream kinases
-0.9 Mkk1p and Mkk2p
0.006
intracellular transport
N[KTY]L
31 NKLY
IBN_N
1.E-06
-0.8
0.007
[ELR]I.D[TNA]
31
ABC_tran
1.E-06
-0.8
0.007
I[LAQ]S
for proper
K[AI][CL]SGK[FI].[PQ]
UBIQUITIN_ACTIVAT_1
PATTERN
and transition from
Metallophos
Meiosis I to II; affects
1.E-02
genome stability
-0.8by suppressing
response
unscheduled
to DNA damage
homologous
stimulus
recombination
(0.001)
0.006
[IVD]ID[LEG]
31 VEID
Helicase_C
1.E-02
-0.7
0.007
TAF14: Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3
Q[QEF]Q
complexes, involved 31
in RNA GQDQTKQQI
43_KD_POSTSYNAPTIC
initiation and in chromatin
PATTERN
modification; contains
Actina YEATS domain
1.E-04
-0.7
0.006
SPT5: Protein that forms a complex with Spt4p and DV.[ASL][RME]
31
pre-mRNA processing
1.E-04
-0.2
0.006
KV..[SKE][AKE]
Pkinase
particles
1.E-03
-0.2
0.006
PRP43: RNA helicase in the DEAH-box family, functionsRK[RME]
I and polymerase
VRKRTLRRL
II transcript
PAK1
metabolism,
kinase involved
substrate
in release
motif of the lariat-intronBrix
1.E-02
-0.2
0.006
SLX5: Subunit of the Slx5-Slx8 substrate-specific N[DNEQ]..[NWC]T
ubiquitin ligase complex; stimulated
Pkinase
1.E-04
-0.2
0.005
TP[PMA]
31cellular
LTP
response to nutrient
RAF1
levels
kinase
and environmental
substrate motif
conditions and progression
Cyclin_N
through the cell
1.E-02
cycle
-0.1
kinase regulator activity (1e-05)
0.006
R.V[TRF]
31 [RK].V.F
PPI binding sites
Helicase_C
1.E-09
0
Y
0.007
[GNY]K[TIM]K
WD40
1.E-02
0
Y
0.006
IMP3: Component of the SSU processome, which is required
K..K[LE]
31 K..K.K
Nuclear
interacts
Localization
with Mpp10p and mediates interactions
WD40
of Imp4p and Mpp10p
1.E-07
with U3 snoRNA
0
0.006
chromosome
K.R[KIE]
31 [IL]Q..C....K.R.WMyosin light chain binding motifs Type 2B Ca
SMC_N
independent 1.E-05
0.1
chromosome (1e-14)
0.007
protein complex
K.[RLA]K
31 SKRKYRK
TP1 PATTERN
SMC_N
1.E-02
0.1
0.007
SPC24: Component of the evolutionarily conserved kinetochore-associated
K[TEH]D
Ndc8031
complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation,
SMC_N
spindle checkpoint
1.E-02
activity and0.1
kinetochore clustering
0.006
UTP8: Nucleolar protein required for export of tRNAs from
SD[IDQ]
the nucleus; also copurifies
31 with
E[ST]D
Ankyrin
processome
G bindingcontaining
motif in the
KNCQ2
U3 snoRNA
and KNCQ3
that WD40
is involved
potaqssium
in processing
channels
1.E-07
of pre-18S0.1
Y
0.006
amine metabolism
K..[DYH]V
31
PALP
1.E-02
0.2
Y
0.007
UTP20: Component of the small-subunit (SSU) processome,
K..K[RLW]
which is involved in the
31biogenesis
KR of the 18S rRNA
CLV_PCSK_PC1ET2_1
WD40
1.E-05
0.2
nucleolus (1e-33)
0.006
I.[NTI]E
31 [ST]E
BRCT
motif
1.E-05
0.3
0.007
nucleus
Q[LKN]A
31
HEAT
1.E-03
0.3
Y
0.007
Q[RED]R
Ndc8031
complex
[KR]R
CLV_PCSK_KEX2_1
involved in chromosome
Y segregation,
SMC_N
spindle checkpoint
1.E-03
activity and0.3
0.006
A..[DRA]R
31 [KR]R
the U3 snoRNA thatCLV_PCSK_KEX2_1
WD40
1.E-03
0.4
0.006
amine metabolism
I..[TAD]G
31
Iso_dh
1.E-03
0.5
0.007
protein binding
AL[PTC][SNM]
31 GTALL
Receptor recycling motif
HEAT
1.E-03
0.7
0.007
GSF2: ER localized integral membrane protein that[PVQ]F..[GFQ]A
may promote secretion of certain
31 hexose transporters, including Gal2p; involved in glucose-dependent repression
Sugar_tr
1.E-03
0.7
0.005
EA[ERP]
complex, mediates
31 interactions
E[ST][EA]REA[RK].[LI]
between theRIBOSOMAL_S28E
5' cap structure and thePATTERN
3' mRNA poly(A) tail, involved
RRM_1
1.E-03
tail length,0.7
interactsRNA
with translation
metabolism
factor (1e-10)
eIF-4G
0.006
matsuyama_Cytosol
N.L[QPI]
31
Y
RhoGEF
1.E-02
0.7
cell septum (1e-06)
Y
0.007
mitotic cell cycle
R..[TKD]S
31 [KR].R..[ST]
p70s6k phosphorylation site
HEAT
1.E-02
0.8
Y
0.007
I[PIL]V[IMY]
31 IP[IV]
Crystallin motif for dimerization
E1-E2_ATPase
1.E-05
0.9
Y
0.007
G.[IDC]I
31of Hsf1p;
VIG..G..I
docks with Tom70p
KH domain,
for mitochondrial
RNA binding
preprotein
motif
delivery; promotes
AA_permease
0.9 addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
0.006
URA2: Bifunctional carbamoylphosphate synthetaseE[TRQ][AWC]L
31
(ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis
HEAT of pyrimidines;
1.E-02
both activities
1 are subject
protein
to feedback
carrier activity
inhibition (0.01)
by UTP
0.005
cytoskeleton
D[KQL]..[KRS]D
31
Y
SH3_1
1.E-02
1.1
Y
0.007
SED5: cis-Golgi t-SNARE syntaxin required for vesicular
TA[GCF][QD]
transport between the ER31
and the Golgi complex, binds at least 9 SNARE proteins
Ras
1.E-05
1.1
0.004
organelle membrane
F[SFY].[FIG]V
31
Mito_carr
1.E-02
1.2
0.006
L[AHP]D
31 LPDEL
Pkinase
1.2
[IPF]K.[WFP]D
31 predominantly nucleolar in distribution, required for 18S rRNA synthesis WD40
1.E-02
1.4
Y
0.005
R[LPF].[QGY]V
the cell cycle
Y
Proteasome
1.E-17
1.4
0.006
[LAM]FA[ITM]
31
Y
E1-E2_ATPase
1.E-03
1.5
Y
0.007
V[GFE]G[GYC]
31
PALP
1.E-02
1.5
0.007
matsuyama_Nucleus
G.[VAF]F
31
MFS_1
1.E-02
1.5
0.007
N[SLC]V[RSN]
31of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes
RasGEF_N
1.5 addition;
signal
interacts
transduction
with Cns1p,
(0.01)
Cpr6p, Cpr7p, Sti1p
0.006
Q[VGM]L[KEY]
groups
31
Pkinase
1.E-21
1.6
Y
(1e-42)0.007
I.D[FST]
31
HEAT
1.E-04
1.7
Y
0.006
A.[EDP]V
synthetases (Mes1p
31 and
IYA.P
Gus1p), deliveringc-Abl
tRNAkinase
to them,phosphorylation
stimulating catalysis,
siteand
(peptide
ensuring
screen)
Pkinase
the cytoplasm; 1.8
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-07)
Y
0.006
G.[PAD]G
31 proteins;
G[FL]PGER..G
regulates chromatid
LIG_IBS_1LIG_IBS_1
cohesion, chromosome segregation,GTP_EFTU_D2
APC-mediated proteolysis,
1.E-02
DNA replication
1.8and septin
protein
ring dynamics
sumoylation (0.001)
Y
0.006
C.L
31 VPGKARKKSSCQLL
Calmodulin-dependent protein kinase IV substrate
Pkinasemotif
1.E-26
1.9
D.[GLP]T
SH3_1
1.E-02
2
cell cycle (1e-06)
Y
0.006
hydrolase activity
Y.[NGQ]A
31 E.Y.[QSG]
Ras
1.E-05
2.1
Y
0.007
G.[KRN]G
20S pre-rRNA
IQ.RG.RG.RRR
processing; identical
Binding tomotif
Rps4Bp
on Calmodulin
and has similarity to rat S4 ribosomal
KH_1protein
1.E-02
2.2
0.006
EN[ILE][LSW]
synthetase
YEN[FIV]
(Mes1p) and Arc1p;
SH2complex
ligand for
formation
Tns (Tyr
increases
must be
thephosphorylated)
catalytic efficiency
Pkinase
of both tRNA1.E-15
synthetases and
2.5
ensuresprotein
their correct
kinase
localization
activity
to the
(1e-14)
cytoplasm
0.006
NOP9: Essential component of pre-40S ribosomes that
D[VKG]..R[GAI]
31 of 35S pre-rRNA and hence formation of 18S rRNA; binds RNA in vitro and
WD40
contains multiple1.E-05
pumilio-like repeats
2.6
0.006
G[SAY][FYM]G
31cytoplasmic
R.GSFvesicles; essential
PKCdelta
for post-Golgi
vesicle transportY site (peptide
Pkinase
screen)
1.E-12
2.8
0.005
YC..G[DS]L
Pkinase
1.E-04
2.8
0.004
matsuyama_periphery
D[LAE]..E[NWP]I
31
Pkinase
1.E-06
2.8
0.008
cell cycle
[HAL]R.I[KSL]
31 [AG]R
Y
Pkinase
1.E-11
3
cell cycle (1e-68)
Y
0.007
SKP1: Evolutionarily conserved kinetochore protein thatD..[TPY]L
31
including the SCF ubiquitin ligase complex, the CBF3 complex thatF-box
DNA, and the RAVE
3 complex
ubiquitin
that regulates
ligase assembly
complexof(1e-09)
the V-ATPase
0.006
NOP13: Protein of unknown function, localizes to theI[AG].PG[RA]
1.E-06of pre-18S
3.6rRNA RNA helicase activity (1e-05)
Y
0.004
nucleus
[GEM]V.W[YIF]
31
SRP1_TIP1
1.E-50
3.7
cell wall (1e-04)
0.006
MAK11: Protein involved in an early, nucleolar step of 60S
GS.KT[LA]
ribosomal subunit biogenesis;
31 essential
YIYGSFK
for cell growth
Src and
kinase
replication
substrate
of killer
motif
M1 dsRNA virus; contains
DEAD
1.E-09
repeats
3.7
Y
0.004
oshea_cytoplasm
V[PLR]W[YFK]
31 VP
Interleukin converting enzyme protease SRP1_TIP1
1.E-50
3.9
cell wall (0.01)
0.006
[GTP]L.Y[LID]H
31 Y[LI]
3(phospho-peptide)
1.E-12
4
0.007
matsuyama_nucleolus
[LVS]V.DE[AGM]
31
DEAD
1.E-10
4.3
nucleolus (1e-10)
0.007
Q[EAM]..R[ATS]
31
Helicase_C
1.E-06
5.2
Y
0.007
WY[SYA]
0.007
[SGQ][KH]KA
R[AGS][AKG]R
32 and[AG]R
has similarity to rat Protease
S8 ribosomal
matriptase
protein protease site
GCD11: Gamma subunit of the translation initiation factor
FL.R[RT]L
eIF2, involved in the identification
32 R.L
of the start codon;Cyclin
binds GTP
A motif
when
that
forming
bindsthe
cdk2
ternary
complexes
complex with GTP and tRNAi-Met
(0.01)
Y
Y
10
8
10
7
10
10
10
10
7
10
8
10
10
10
10
10
9
9
9
10
10
9
7
10
9
10
10
9
10
10
10
9
10
10
10
10
10
9
10
8
10
9
9
10
9
9
10
10
9
10
10
10
10
10
10
10
10
10
10
10
10
9
7
10
10
8
10
10
10
10
10
10
10
9
9
10
9
9
9
10
9
10
10
10
10
8
8
9
10
10
10
10
10
10
9
10
10
10
10
8
9
10
9
10
10
9
10
10
10
9
9
9
10
10
10
10
9
8
10
8
9
8
7
10
10
9
8
10
7
10
9
10
10
10
yeast-942_GO-0043228
yeast-921_GO-0006810
yeast-792_GO-0006412
yeast-610_GO-0031090
yeast-548_GO-0051641
yeast-470_GO-0006259
yeast-468_GO-0051276
yeast-436_GO-0031323
yeast-424_GO-0006950
yeast-424_GO-0006950
yeast-410_GO-0007049
yeast-341_GO-0045449
yeast-304_GO-0019752
yeast-304_GO-0006082
yeast-267_GO-0044265
yeast-251_GO-0005886
yeast-238_GO-0017111
yeast-238_GO-0017111
yeast-235_GO-0000278
yeast-233_GO-0006629
yeast-222_GO-0009308
yeast-216_GO-0006325
yeast-216_GO-0006325
yeast-216_GO-0006323
yeast-216_GO-0006323
yeast-215_GO-0007010
yeast-215_GO-0007010
yeast-205_GO-0005856
yeast-1493_GO-0043234
protein_40_YPR144C
protein_40_YPR119W
protein_40_YPR110C
protein_40_YPL217Cs
protein_40_YPL211W
protein_40_YPL209C
protein_40_YPL204W
protein_40_YPL153C
protein_40_YPL126W
protein_40_YPL012W
protein_40_YPL004C
protein_40_YOR308C
protein_40_YOR174W
protein_40_YOR174W
protein_40_YOR061W
protein_40_YOR039W
protein_40_YOL133W
protein_40_YOL133W
protein_40_YOL133W
protein_40_YNL289W
protein_40_YNL244C
protein_40_YNL175C
protein_40_YNL118C
protein_40_YMR242C
protein_40_YMR242C
protein_40_YMR236W
protein_40_YMR229C
protein_40_YMR186W
protein_40_YMR186W
protein_40_YMR117C
protein_40_YMR116C
protein_40_YMR106C
protein_40_YMR106C
protein_40_YMR093W
protein_40_YMR001C
protein_40_YMR001C
protein_40_YML010W
protein_40_YML010W
protein_40_YLR372W
protein_40_YLR249W
protein_40_YLR129W
protein_40_YLL011W
protein_40_YKL203C
protein_40_YJR066W
protein_40_YJR002W
protein_40_YJL164C
protein_40_YJL164C
protein_40_YJL109C
protein_40_YJL109C
protein_40_YJL092W
protein_40_YJL092W
protein_40_YJL074C
protein_40_YJL074C
protein_40_YJL074C
protein_40_YIL061C
protein_40_YIL035C
protein_40_YHR197W
protein_40_YHR165C
protein_40_YHR135C
protein_40_YHR135C
protein_40_YHR082C
protein_40_YHR052W
protein_40_YHL007C
protein_40_YHL001W
protein_40_YGR218W
protein_40_YGR103W
protein_40_YGR086C
protein_40_YGR040W
protein_40_YGR040W
protein_40_YGR040W
protein_40_YGL179C
protein_40_YGL179C
protein_40_YGL179C
protein_40_YGL120C
protein_40_YGL106W
protein_40_YGL030W
protein_40_YFR034C
protein_40_YFL039C
protein_40_YFL037W
protein_40_YER177W
protein_40_YER082C
protein_40_YER036C
protein_40_YEL037C
protein_40_YDR510W
protein_40_YDR448W
protein_40_YDR448W
protein_40_YDR448W
protein_40_YDR414C
protein_40_YDR365C
protein_40_YDR324C
protein_40_YDR303C
protein_40_YDR225W
protein_40_YDR145W
protein_40_YDR099W
protein_40_YDR012W
protein_40_YDL213C
protein_40_YDL213C
protein_40_YDL213C
protein_40_YDL213C
protein_40_YDL055C
protein_40_YDL047W
protein_40_YDL047W
protein_40_YBR251W
protein_40_YBR181C
protein_40_YBR159W
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
WY[SYA]
[TKG]G..[FRE]GN
31
protein export from nucleus (0.001)
TT[TNR]
E[EFS].E[DGW]
31 F.E
DNA binding motif in MutS
Q.[LQF]S
31
Y
DNA metabolism
[KAG]S[EIM]S
31
Y
[KAI]R..[ENH]EE
31 [KR]R
CLV_PCSK_KEX2_1
[SLQ]S.R[LQP]E
31 S.R
PKC phosphorylation motif
Y
response to stress
D.D[EKV]
31 D.D
response to stress
E[LEW].[NDK]L
31
cell cycle
R..[IEA]T
31
Y
cell cycle (1e-12)
[KQH]IR[ESM]
31
Y
PI[TAM]
31 IP[IV]
PI[TAM]
31 IP[IV]
LE.S[GFV][SHM]
31
cellular macromolecule catabolism (1e-09)
plasma membrane
C..A[TIC]
31
D[AR][QH]S
31
E.[IRV]K
31 YE.[IV]
Y
mitotic cell cycle
K..[DLP]Q
31
lipid metabolism
AF[IAS]
31 F[MLVI]Y
amine metabolism
T[ISQ]..EK[VPD]
31 [ST]..E
[VI]Q..Q[QPI]
31
establishment and/or maintenance of chromatin architecture (1e-30)
L[LTM][EAG]Q
31 LLG
DNA packaging
[VI]Q..Q[QPI]
31
DNA packaging
L[LTM][EAG]Q
31 LLG
[ADC]P.[PSH]P
31 P.[ST]P
Erk p44 MAP kinase phosphorylation
Y
site
Q..E[ILP]
31
cytoskeleton
K[REV]LN[DFN]
31 KR
CLV_PCSK_PC1ET2_1
Y
protein complex
[SMP]L[SFC]S
31
[LE]K..G[LN]T
I[DSA]..LD[DKY]
31the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
Y
[EIR]V[NAP]Q
I and III
31 VP
transcription from RNA polymerase III promoter (0.01)
BMS1: Essential conserved nucleolar GTP-binding protein
K..D[FTV]
3140S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity
rRNA
to Tsr1p
processing (1e-23)
Y
[EWQ]I..[SG]T
of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
[SIV]K..[KRG]K
attachments; helps
31 maintain
K[KR].[KR]
condensed chromosomes
Nuclear localization
during anaphase
motif and early telophase; associates with Sli15p, which promotes Ipl1pspindle
association
midzone
with mitotic
(0.01)
spindle
Y
HRR25: Protein kinase involved in regulating diverseDD[DVC][VSF]
31 Y[DQ]DV
SH2 ligandsegregation;
for Blnk (Tyr
binds
must
the be
CTDphosphorylated)
RAD53: Protein kinase, required for cell-cycle arrestN[AYQ]..E[LIQ]
Y
NAN1: U3 snoRNP protein, component of the small[KAF]R..[TMQ]G
31 [KR]R
CLV_PCSK_KEX2_1
required for the biogenesis of18S rRNA
RRP12: Protein required for export of the ribosomalEK.[SMY][KAT]
31 components of the pre-ribosomes; contains HEAT-repeats
nucleolus (1e-21)
LSP1: Primary component of eisosomes, which areG[NSQ]..S[RLF]
large immobile patch structures
31at theS..S
Casien
with endocytosis,
kinase I phosphorylation
along with Pil1pY
and
site,Sur7p;
1st Ser
nullmust
mutants
be phosphorylated
show activation of Pkc1p/Ypk1p stress resistance pathways
SNU66: Component of the U4/U6.U5 snRNP complexR[IHG].[KV]R
involved in pre-mRNA splicing
31 via spliceosome;
KR
has homology
CLV_PCSK_PC1ET2_1
to human SART-1 and to an S. pombe protein; snu66 null mutation confers cold-sensitivity
U4/U6
but isxnot
U5
lethal
tri-snRNP
at normal complex
growth temperatures
(0.001)
[QMC]D[LSR]I
31
P[QPH]Y[INV]
31 NP.Y
subunits to formLIG_PTB_1LIG_PTB_1
the RNA polymerase II holoenzyme; essential for transcriptional regulation
CKA2: Alpha' catalytic subunit of casein kinase 2, aRG[SWH][KWT]
31in cell
RGD
LIG_RGDLIG_RGD
the holoenzyme also contains Y
CKA1, CKB1 and CKB2, the many substrates include transcription
establishment
factors and
and/or
all RNA
maintenance
polymerases of chromatin architecture (1e-04)
CKB2: Beta' regulatory subunit of casein kinase 2, a[TQA]KP[AEY]
31 in cell
KP..[QK]
LIG_SH3_4LIG_SH3_4
the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription
RNA polymerase
factors and all
II RNA
transcription
polymerases
elongation factor activity (1e-04)
[IND]LA[AFN]
Y
FT..[KAH][KFL]
31(SCF);
FTY
required for Gic2p,mTOR
Far1p, kinase
Sic1p and
substrate
Cln2p degradation;
motif
may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF
Y
I[RET][KSL]E
31(SCF);
[ST]E
required for Gic2p,GFar1p,
protein-coupled
Sic1p and Cln2p
receptor
degradation;
kinasemay
1 substrate
tether Cdc34p
motif(a ubiquitin conjugating enzyme or E2)
protein
and Cdc53p
catabolism
(a cullin)(0.001)
subunits of SCF
Y
PCL1: Pho85 cyclin of the Pcl1,2-like subfamily, involvedT.N[NDF]
Y
SUI1: Translation initiation factor eIF1; component of a complex
F..E[GIA]
involved in recognition
31 ofGFRGE[AG]L
the initiator codon; modulates
DNA_MISMATCH_REPAIR_1
translation accuracy at the
PATTERN
Yinitiation phase
eukaryotic translation initiation factor 3 complex (0.01)
NOP13: Protein of unknown function, localizes to theD[DSH]E[EQC]
contains
SD.E
an RNA recognition
Casein
motif (RRM)
kinase
and
II has
substrate
similarity
motif
to Nop12p, which is required for processing of pre-18S rRNA nucleolus (1e-11)
Y
K[INW]S[SMH]
31 S[ST]
the 5' cap structureMDC1
from mRNAs
BRCTprior
domain
to their
binding
degradation;
motif member of the Nudix hydrolase family
cytoplasmic mRNA processing body (0.01)
Y
A.[GAK]K
to Rpl20Bp
VPGKARKKSSCQLL
and has similarity
Calmodulin-dependent
to rat L18a ribosomal protein
protein kinase IV substrate motif
Y
R.[QGA]K
to Rpl20Bp
GR.A
and has similarity
Protease
to rat L18a
tPAribosomal
proteolytic
protein
site
Y
LT.[QLI][NQI]
31 II transcription
LLTP initiation and
WD40
in chromatin
domain modification,
of Cdc4 binding
similarmotif,
to histone
Thr must
H3 be phosphorylated, CPD motif
Y
RRP5: Protein required for the synthesis of both 18S[EPR]V.A[KLW]
31 isFGPVVA
Zyxinofmotif
18S rRNA
that and
binds
N-terminal
alpha-actinin
region is required for the 5.8S rRNA; component of small ribosomal
nucleolus
subunit(1e-13)
(SSU) processosome
HSC82: Cytoplasmic chaperone of the Hsp90 family, redundant
E.I[NEP]
in function and nearly
31 identical
YE.[IV]
with Hsp82p, and
SH2together
ligand they
for Fes
are essential;
(Tyr mustexpressed
be phosphorylated)
constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
HSC82: Cytoplasmic chaperone of the Hsp90 family,PK[LVA][EVH]
redundant in function and nearly
31 identical
LPKYwith Hsp82p, and
WWtogether
motif (non-conventional
they are essential; expressed
) in spt23constitutively
for bindingatto10-fold
WW domain
higher basal
of RSP5p,
levels than
also
HSP82
for NEDD4
and induced
WW2-3
domain
fold by heat shock
SPC24: Component of the evolutionarily conserved [LIV]D..S[RKY]
SE..[PSV]L[NEL]
31 ortholog
[ST]Eof RACK1 thatGinhibits
protein-coupled
translation; core
receptor
component
kinase
of the
1 substrate
small (40S)
motif
ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
[GWY]F..[NH]K
Q[IQM]..T[FRY]
[DV]K.[VTA]K
Y
KR..[LSA][LEN]
at budKR
neck, nucleus and SPBs;
CLV_PCSK_PC1ET2_1
has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may
cohesin
be a Cdc28p
complex
substrate
(1e-05)
LQ.[NQS][IVS]
at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may
cellbecycle
a Cdc28p
(1e-06)
substrate
[KIQ]A.[AYE]D
31
Y
L.[DSH]D
31 LEHD
Protease
Spt4p-Spt5p
Caspase complex
9
also plays
Y a role in pre-mRNA processing
Y
SUR4: Elongase, involved in fatty acid and sphingolipid biosynthesis;
A[VY]F synthesizes 31
very long
AEV[IVLF]YAA[PF]F
chain 20-26-carbon
Ablfatty
kinase
acidssubstrate
from C18-CoA
motifprimers; involved in regulation of sphingolipid biosynthesis
lipid biosynthetic process (1e-04)
Y
YEF3: Translational elongation factor 3, stimulates the binding
V.[GVF]E
of aminoacyl-tRNA 31
(AA-tRNA)
[RK].V.F
to ribosomes byPPI
releasing
binding
EF-1
sites
alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
DIP2: Nucleolar protein, specifically associated withRK..[EKH][SAD]
RRK.[ST] complex
ZIPknown
kinase
asphosphorylation
motif processome, required for 18S rRNA biogenesis, part of the
rRNA
activeprocessing
pre-rRNA processing
(1e-20)complex
LT.[DYC][GDK]
31 similarity
LLTPto the beta subunit
WD40
of trimeric
domainG-proteins
of Cdc4 binding
and the splicing
motif, Thr
factor
must
Prp4p
be phosphorylated, CPD motif
Y
TOR2: PIK-related protein kinase and rapamycin target; SF[QEV]
involved in meiosis
Y
N[KTN]I[FCT]
plasma
and autophagy;
membrane
involved
(1e-10)
in meiosis
Y
MPP10: Component of the SSU processome, which[EKP]K.S[RKE]
31 RKK.[ST]
interacts with and
ZIPcontrols
kinasethe
phosphorylation
stability of Imp3pmotif
and Imp4p, essential for viability; similar to human Mpp10p
Y
[FPR]P..[KLI]D
S..[PRV]K
[DHP]E[ESK]D
31 E[ST]D
the U3 snoRNA thatAnkyrin
is involved
G in
binding
processing
motifofin
pre-18S
KNCQ2
rRNA
and KNCQ3 potaqssium channels
E[ETC].D[QMR]
F[KTL]K
for proper
S..F.K
LIG_BRCT_BRCA1_2
to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing
response
unscheduled
to DNA damage
homologous
stimulus
recombination
(0.001)
R.I[DGS]
Y
SMC3: Subunit of the multiprotein cohesin complex DY.[DNR][LGY]
31 [DE]Y
in mitotic cells; alsoEGFR
required,
kinase
with Rec8p,
substrate
for cohesion
motif and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
Y
E.K[EQM]
31
in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved
cohesin
SMC chromosomal
complex (1e-04)
Y
R[DSI].S[FM]
31 F.R..S[FM][FM]
in mitotic cells; alsoPKC
required,
zetawith
kinase
Rec8p,
substrate
for cohesion
motifand recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
SNP1: Component of U1 snRNP required for mRNAQF.[SPY][KQP]
A[TPI][GEK]S
31in cell growth and proliferation; the holoenzyme also contains Y
CKA2, CKB1 and CKB2, the many substrates include transcription
nuclearfactors
lumen
and(0.001)
all RNA polymerases
[SD][IY].NSF
31for processing
Y.N
of ITS2 sequences
LIG_SH2_GRB2
from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
PRP8: Component of the U4/U6-U5 snRNP complex,
L[ESL]..[EAS]R
involved in the second catalytic
31 step[AG]R
of splicing; mutations
Protease
of human
matriptase
Prp8 causeprotease
retinitis pigmentosa
site
RNA splicing (1e-21)
Y
PVI isoform; shares redundant
31 CPV
Heme
in morphogenesis,
binding site in
proper
mitochondrial
septin assembly,
hemeendocytic
lyases trafficking; provides an essential function overlapping with that of Yck2p
YCK1: Palmitoylated, plasma membrane-bound casein V..[NKD]K
31
functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function
RNA
overlapping
processing
with that
(0.01)
of Yck2p
K..[GVN]G
Y
EE..[DNG][GYI]
31 role
EED
Ankyrin
specificity;
B C-terminal
also copurifies
motif that
with
binds
66S pre-ribosomal
internal Ankyrin
particles
repeats
[ELR]Q..Q[QKH]
31in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif bud
present
(0.01)
[KDR]AG[KCM]
CRM1: Major karyopherin, involved in export of proteins,S.[QTF]Q
31 from the nucleus
R[GEF]..I[PNK]
31
cytoplasm
cell proliferation
PIL1: Primary component of eisosomes, which are largeK..[EVF]V
31 associated with endocytosis; null mutants show activation of
Y Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated
SWR1 complex
state in(0.01)
mitochondria
[KHW]T..F[LRY]
31
that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
A[STA]..N
31
Y
KSS1: Mitogen-activated protein kinase (MAPK) involved in T.E
signal transduction pathways
31 CP[LP]T.E[ST].C
GM_CSF
growth PATTERN
and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional
invasive
in W303
growth
strains
(sensu Saccharomyces) (1e-04)
D.E[DTY]
for theSD.E
phosphorylation and
Casein
activation
kinase
of Snf1p;
II substrate
functionally
motif
orthologous
Y
to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
E[DTW].H[ETY]
for theHE.GH
phosphorylation and
Protease
activationAAA
of Snf1p;
proteases
functionally
- cutorthologous
membranetoproteins
LKB1, a mammalian
metal binding
kinase
site
associated with Peutz-Jeghers cancer-susceptibility syndrome
N.N[ESQ]
P[NER].[KAV]A
nucleolus (1e-18)
Y
MLC1: Essential light chain for Myo1p, light chain for S[QE]F[ICW]
31 SQ
ATM kinase
with Myo1p,
substrate
Iqg1p,
motif
and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
RPL30: Protein component of the large (60S) ribosomalA.[GAK]K
31L30 ribosomal
VPGKARKKSSCQLL
protein; involved
in pre-rRNA processing
protein
in thekinase
nucleolus;
IV substrate
autoregulates
motif
splicing of its transcript
Y
[PTS]P[PGD]H
31 [ST]P
with Pho2p to the
LIG_WW_4LIG_WW_4
PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability
E.[EYV]I
cytoskeletal
EEEIYEEIE
functions
cFPS/FES kinase phosphorylation site
cell cortex (1e-16)
[KQT]R.[TWF]V
31dimer,
[KR]R
which polymerizesCLV_PCSK_KEX2_1
Y
S[TPA].N[LDF]
31bindsS[ST]
involvedBRCT
in regulation
domain
of many
binding
processes
UTP7: Nucleolar protein, component of the small subunitI..A[RGV]
Y
V[EQI].[EGQ]K
ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p translation (0.01)
D[PMW][AME]L
31(with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2);
protein
homolog
catabolism
of human HR23A
(0.001)
and HR23B proteins
K.[DVQ]G
31 proteins;
[EDQH].K.[DN]G.R[GACIVM]
regulates chromatid
DNA_LIGASE_A1
PATTERNsegregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
[PTM]P.N[ELQ]
adaptor/HAT
[ST]P(histone acetyltransferase)
LIG_WW_4LIG_WW_4
complexes
Y
SAGA complex (0.001)
ADA2: Transcription coactivator, component of the ADAR..Q[LGT]
R[SLR].P[NY]
ERD1: Predicted membrane protein required for the retention
[TF]N.W[IA]
EE.[SEF][DKL]
31decreased
EED 18S rRNA levels
nucleolus (1e-13)
[IFV]E..[ELT]G
[NYD][KNL]..DA
chromosome
to Rsc30p organization and biogenesis (sensu Eukaryota) (1e-04)
HTA1: One of two nearly identical (see also HTA2) A[DGP]..A[EKQ]
31 required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates
nuclear
DNAlumen
repair; acetylated
(0.001) by Nat4p
ST[QPH]
31 [KR]STQT
Light
and
chain
in chromatin
8 of dynein
modification,
bindingsimilar
motif to histone H2A
ID..[DFA][SVP]
[RSK]A.R[AVK]
Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins
[GFR]T..[ICH]G
31RNAT..[IL]
FHA2
and
binding
has similarity
motif, to
Thr
hydrophilins;
must be phosphorylated
NOP6 may be a fungal-specific gene as no homologs have
rRNA
beenmetabolism
yet identified in(1e-04)
higher eukaryotes
[VPE]G.R[VGA]
nucleolus
been yet identified
E[KFP]..A[AQP]
ribosome
been yet biogenesis
identified in higher
(1e-05)
eukaryotes
R..L[TPI]
31RNAR..L
LIG_APCC_Dbox_1
nucleolus
been yet identified
GE..[KSF][PVI]
guanyltransferase),
Y
SIT4: Type 2A-related serine-threonine phosphatase that[DIT]..IG
functions in the G1/S transition
31 of
FIGQY
the mitotic cycle; cytoplasmic
Ankryn G binding
and nuclear
motif
protein
in neurofascin
that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
SIT4: Type 2A-related serine-threonine phosphatase
A[SHY].[SCW]N
31 of the mitotic cycle; cytoplasmic and nuclear protein that modulates
Y
functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
MRPS5: Mitochondrial ribosomal protein of the smallI[PMR].[NPW]L
subunit
31
RPS6B: Protein component of the small (40S) ribosomalL.[NSY]L
31 andL..L..L.L
has similarity to rat Nuclear
S6 ribosomal
export
protein
signal
IFA38: Microsomal beta-keto-reductase; contains oleate F..[STF]L
31
in the promoter region; mutants exhibit reduced VLCFAYsynthesis, accumulate high levels of dihydrosphingosine,endoplasmic
phytosphingosine
reticulum
and medium-chain
(1e-12)ceramides
Y
transport
organelle membrane
0.007
0.007
0.007
0.007
0.007
0.007
0.007
0.007
0.007
0.006
0.007
0.007
0.007
0.007
0.005
0.007
0.006
0.007
0.007
0.007
0.005
0.007
0.007
0.007
0.007
0.007
0.007
0.006
0.007
0.004
0.005
0.006
0.006
0.005
0.006
0.006
0.006
0.005
0.006
0.006
0.004
0.005
0.004
0.004
0.005
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.004
0.004
0.005
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.005
0.006
0.005
0.005
0.006
0.004
0.006
0.006
0.006
0.006
0.006
0.006
0.005
0.006
0.006
0.006
0.006
0.006
0.006
0.006
0.005
0.006
0.006
0.004
0.006
0.006
0.006
0.004
0.006
0.006
0.006
0.005
0.006
0.005
0.006
0.004
0.004
0.006
0.006
0.006
0.006
0.005
0.006
0.006
0.005
0.005
0.006
0.006
0.006
0.006
0.005
0.006
0.006
0.006
10
10
10
10
10
10
10
10
10
10
10
9
10
10
8
10
9
9
10
10
9
10
10
10
10
10
10
10
10
9
10
10
10
7
10
10
9
10
9
10
7
8
7
8
9
10
8
10
10
10
10
10
10
9
9
9
10
8
9
7
9
9
10
10
9
10
10
10
10
10
10
10
9
9
10
10
10
10
10
10
10
10
8
9
10
7
10
10
10
9
9
9
9
10
10
10
8
10
10
10
9
9
10
9
10
10
10
9
10
10
10
8
10
8
9
9
7
10
10
9
10
9
9
10
9
10
10
10
10
9
9
9
9
10
protein_40_YBR142W
2 MAK5: Essential nucleolar protein, putative DEAD-box RNA
A.[GRP]K
helicase required for maintenance
31 IYA.Pof M1 dsRNA virus;
c-Ablinvolved
kinase in
phosphorylation
biogenesis of large
site
(60S)
(peptide
ribosomal
screen)
subunits
nucleolus (1e-13)
0.006
10
protein_40_YBR109C
[IKH]PE[FN]
Y
0.006
10
protein_40_YBR010W
2 HHT1: One of two identical histone H3 proteins (see [ETN]N..[KD]S
31 for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation,
regulationand
of mitotic
nucleobase,
phosphorylation
nucleoside, nucleotide and nucleic acid metabolism
0.006 (1e-07)9
protein_40_YBL092W
2 RPL32: Protein component of the large (60S) ribosomal S.L[SLT]
31L32 ribosomal protein; overexpression disrupts telomeric silencing
0.006
10
protein_40_YAL032C
[NAD]K..[LQN]L
nuclear
transcription
mRNA
of asplicing,
reporter gene
0.006
9
protein_40_YAL032C
L[KSP].D[FER]
31 interacts
S.D with splicing factors
CAMKII
Prp22p
phosphorylation
and Prp46p; orthologous
site
mRNA
transcription
processing
of a reporter
(1e-08)
gene
0.006
10
oshea_vacuole
2 oshea_vacuole
FF[VYI]
31 F[MLVI]Y
storage vacuole (1e-16)
0.006
10
oshea_spindle_pole
2 oshea_spindle_pole
D[STF]..[LGE]M
31
0.005
10
2 oshea_punctate_composite
ND[LRC]
31 DRY
Binding motif for interaction of G-proteins or Phospholipase D with G-alpha
0.006
10
[FST][GDL].KP
31 FKPY
TLA binding motif in Brinker transcription factor for binding TLA domain in Groucho nuclear pore (1e-16)
Y
0.007
10
A[NQI]S
nuclear membrane part (1e-38)
0.006
10
FG..[PAM][ASF]
31
0.006
8
P..A[GYR]
31
0.006
10
V[LFM]..V[FGW]
31
0.007
10
VF[AIG]
31 EEEEYVFI
PDGFR kinase substrate motif
0.006
10
oshea_bud_neck
2 oshea_bud_neck
D.M[ERL]
31 LFDLM
0.006
10
IS..E[SAC][LAR]
31 [ST]..E
spindle (1e-15)
Y
0.008
9
K.R[RET]
31 [IL]Q..C....K.R.WMyosin light chain binding motifs Type 2B Ca independent
spindle (1e-10)
0.008
10
matsuyama_periphery
I[EMC]..[EH]E
31
0.008
10
A..[PSQ]Q
31 [ST]Q
ATM kinase phosphorylation siteY
Y
0.008
10
E[TLS]K
31 ES[RK][FY][YST]FH[PS][IV][ES]D
LIG_WH1LIG_WH1
Y
0.008
10
I[IQA][KLD]D
31
0.008
9
matsuyama_ER
2 matsuyama_ER
D..[KVH]R
31 [KR]R
CLV_PCSK_KEX2_1
0.008
10
matsuyama_Cytosol
2 matsuyama_Cytosol
R.[MVG]V
31 H.R.G
Motif for cell cycle arrest in SIV virus
Y
Y
0.007
10
P..Q[VNQ]
31 KP..[QK]
LIG_SH3_4LIG_SH3_4
Y
0.008
10
genetic_YPL055C
[KNE]T.S
31 [RK].[RK][ST].S
diploid null mutant
Akt displays
kinase substrate
delayed premeiotic
motif DNA synthesis and reduced efficiency of meiotic nuclear division
10
genetic_YPL055C
R..K[RSN]
31 R..Kdiploid null mutant
SH3displays
bindingdelayed
motif for
premeiotic
GADS DNA
SH3
Ysynthesis
recognizing
and reduced
slp-76 motif
efficiency
(nonconventional)
of meiotic nuclear division
10
genetic_YNL153C
P.[TQH]S
specifically
NPK[ST]SG.AR
PROK_SULFATE_BIND_2
and transfers target proteins
PATTERN
to it
Y
0.006
10
genetic_YNL153C
Q.[GID]V
asexual reproduction (0.001)
Y
0.006
10
genetic_YLR200W
[FNL]AK
31folding
[PT]GKHG.AK
IF5A_HYPUSINE
and actinPATTERN
cell cycle (1e-09)
Y
0.006
10
genetic_YLR200W
K..[HDM]Q
cytoskeleton organization and biogenesis (0.001)
Y
0.005
10
genetic_YLR039C
E..S[IYE]
31
10
genetic_YGL058W
2 RAD6: Ubiquitin-conjugating enzyme (E2), involved in[LWP]TQ[EPN]
31 [ST]Q
ATM
silencing,
kinaseand
phosphorylation
ubiquitin-mediated
siteN-end rule protein degradation (with Ubr1p)
Y
0.006
9
genetic_YGL058W
Q.[LDS]L repair (with Rad18p),
31
0.006
9
genetic_YGL020C
2 GET1: Subunit of the GET complex; required for the retrieval
D..[DIQ]D
10
genetic_YGL020C
2 GET1: Subunit of the GET complex; required for the retrieval
L.D[ETH]
31the Golgi
LPDEL
to the ER in an ERD2
Motif dependent
in CBP forfashion
interaction
and forwith
normal
PPARg-LBD
mitochondrial
(secondary
morphologysite)
and inheritance
10
genetic_YER083C
2 GET2: Subunit of the GET complex; required for meiotic T..[DKQ]I
31retrieval
PT..[DI]
of HDEL proteinsFHA
from binding
the Golgimotif
to the ER in an ERD2 dependent fashion; may be involved in cell wall function chromosome organization and biogenesis (sensu Eukaryota)
Y
(1e-14) 0.006
10
genetic_YEL003W
R...E
specifically
RE..E
Iron binding
and transfers
motif intarget
ferritin
proteins
L-chain
to itand yeast Iron transport protein
10
genetic_YDL020C
2 RPN4: Transcription factor that stimulates expression
[LQK][KDN].LDV
levels are in turn regulated by the 26S proteasome in a negativeYfeedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
Y
0.006
10
genetic_YDL020C
2 RPN4: Transcription factor that stimulates expression ofD..[QLP]N
proteasome genes; Rpn4p31
levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated
chromosome
by various
organization
stress responses
and biogenesis (sensu Eukaryota) (1e-07) 0.006
9
genetic_YDL020C
2 RPN4: Transcription factor that stimulates expression of L..E[LEP]
levels S[LW]LD[DE]EL[LM]
are in turn regulatedTRG_LysEnd_GGAAcLL_2
by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated
chromosome
by various
organization
stress responses
10
genetic_YAL024C
2 LTE1: Putative GDP/GTP exchange factor required for mitotic
K..N[TSP]
31 acts
CK..NTF
RNASE_PANCREATIC
exchange factor (GEF)
PATTERN
for Tem1p, which is a key regulator of mitotic exit; physically associates
cell cycle
with Ras2p-GTP
(1e-11)
0.006
10
protein_40_YBR160W
A..L[ARL]
31
associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs)
Y which direct
Pkinase
the CDK to specific
1.E-06
substrates 3.3
0.006
10
yeast-235_GO-0000278
T.[EDH]L
30 T..[IL]
Kinesin
1.E-03
-2.3
0.006
10
protein_40_YBR159W
2 IFA38: Microsomal beta-keto-reductase; contains oleateV..[VFM]L
30
MFS_1 high levels
1.E-04
-2.2
endoplasmic
phytosphingosine
reticulum
and medium-chain
(1e-08)ceramides
Y
0.005
10
protein_40_YJR059W
2 PTK2: Putative serine/threonine protein kinase involvedP..[PRE]R
30across
[KR]R
plasma membrane;
CLV_PCSK_KEX2_1
Y
Pkinase
1.E-03
-2
0.006
9
protein_40_YAR019C
2 CDC15: Protein kinase of the Mitotic Exit Network that is
S..[PWH]S
30 bodies
S...S
at late anaphase;WD40
promotes
binding
mitoticmotif,
exit bySer
directly
residues
switching
must
onbe
thePkinase
phosphorylated
1.E-18
-2
0.006
9
matsuyama_periphery
T..[PSL]N
30 T..[SA]
Pkinase
1.E-04
-2
0.007
9
protein_40_YML010W
A..[KEF]R
30 [KR]R
CLV_PCSK_KEX2_1
Spt4p-Spt5p complex also plays a role in DEAD
pre-mRNA processing
1.E-03
-1.8
0.005
10
yeast-324_GO-0030528
[TNS][GHS]EK
30 [ST]E
G protein-coupled receptor kinase
Y 1 substrate
zf-C2H2
motif
1.E-17
-1.6
0.007
9
protein_40_YNL002C
2 RLP7: Nucleolar protein with similarity to large ribosomalAR[NKA]
30 [AG]R
of 66S pre-ribosomalProtease
particles; matriptase
plays an essential
protease
role in
site
processing of precursors
Brix
to the large
1.E-02
ribosomal subunit
-1.6 RNAs
0.006
10
protein_40_YGL106W
2 MLC1: Essential light chain for Myo1p, light chain forLE.[ISV][SPE]
30
to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate
UCH
formation and contraction
1.E-02 of the-1.6
actomyosin ring with targeted membrane deposition
0.006
10
protein_40_YDR087C
2 RRP1: Essential evolutionarily conserved nucleolar protein
AR[AKW]
30of 60S
[AG]R
ribosomal subunits
Protease
and processing
matriptase
of pre-rRNAs
protease
to mature
site rRNAs, associated
Brix
with several
1.E-02
distinct 66S-1.6
pre-ribosomal
nucleolus
particles
(1e-14)
0.006
9
yeast-1216_GO-0009058
2 biosynthesis
Q.Q[QNE]
30
zf-C2H2
1.E-02
-1.5
0.006
10
yeast-345_GO-0006396
2 RNA processing
T[PMQ]G[RTM]
30
Helicase_C
1.E-17
-1.4
0.007
10
yeast-1036_GO-0005739
2 mitochondrion
S[ANF]..[SNP]N
30
zf-C2H2
1.E-02
-1.4
transcriptional activator activity (1e-09)
0.006
9
protein_40_YNL069C
2 RPL16B: N-terminally acetylated protein component of K..[AKR]A
30 K[KR].[KR]
Nuclear
has similarity
localization
to Rpl16Ap,
motifE. coli L13 and rat
Ribosomal_60s
L13a ribosomal proteins;
1.E-02
transcriptionally
-1.4
regulated
cytosolic
by Rap1p
Y
0.006
9
protein_40_YGL105W
LD[DLA]synthetases (Mes1p
30 and
S[LW]LD[DE]EL[LM]
Gus1p), deliveringTRG_LysEnd_GGAAcLL_2
tRNA to them, stimulating catalysis, and ensuring
Pkinase
the cytoplasm;-1.4
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-15)
0.006
10
yeast-285_GO-0012505
2 endomembrane system
L.L[LGV]
30 DALDL
Adaptin_N
1.E-04
-1.3
0.006
10
yeast-593_GO-0031981
2 nuclear lumen
Q.K[QRA]
30 KR
CLV_PCSK_PC1ET2_1
Helicase_C
1.E-06
-1.2
0.006
10
yeast-376_GO-0019219
2 regulation of nucleobase, nucleoside, nucleotide and nucleic
Q..S[HGD]
acid metabolism
30
zf-C2H2
1.E-09
-1.2
Y
acid metabolism
0.006 (1e-11)9
yeast-294_GO-0006366
N..[TGL]T
30
bZIP_1
1.E-03
-1.2
0.006
10
protein_40_YML010W
AR[NGT]
30 [AG]R
Protease
Spt4p-Spt5p
matriptasecomplex
protease
alsosite
plays a role in DEAD
pre-mRNA processing
1.E-05
-1.2
Y
0.005
10
protein_40_YLR009W
2 RLP24: Essential protein with similarity to Rpl24Ap andK.K[VQD]
pre-60SKRKQISVR
ribosomal subunitsPhosphorylase
and required for ribosomal
kinase substrate
large subunit
motif
biogenesisBrix
1.E-03
-1.2
0.006
10
protein_40_YHR196W
2 UTP9: Nucleolar protein, component of the small subunitK[EDI]K
30 the
U3 snoRNA that isDEHYDRIN_2
PATTERN
of pre-18S rRNA
WD40
1.E-03
-1.2
Y
0.006
10
protein_40_YOR272W
2 YTM1: Constituent of 66S pre-ribosomal particles, required
E..K[LKY]
Brix
1.E-02
-1.1
0.005
10
protein_40_YAR019C
[LCG]S..P[TRF]
30 bodies
S.IP
at late anaphase;EB1EB1EB1EB1EB1EB1
promotes mitotic exit by directly switching on thePkinase
1.E-12
-1.1
Y
0.006
9
E.[DNF]E
30 EEEEYFELV EGFR kinase substrate motif
IBN_N
1.E-04
-1
Y
0.007
10
yeast-648_GO-0050791
[FTK]T...K
30
Y
Zn_clus
1.E-03
-0.9
Y
0.006
10
protein_40_YOR181W
[FCE]A.[NMT]L
SH3_1 of the human
1.E-06
Wiskott-Aldrich
-0.9syndrome protein (WASP)
0.005
9
protein_40_YOL133W
S..[KRA]I
conjugating enzyme
-0.9 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(1e-08)
of SCF
Y
0.006
10
protein_40_YMR047C
2 NUP116: Subunit of the nuclear pore complex (NPC) thatS[EYN]L
of the S[LW]LD[DE]EL[LM]
GLFG motif that interacts with mRNA exportIBN_N
with karyopherin
-0.9
Kap95p;nuclear
homologous
pore
to (1e-37)
Nup100p
0.006
10
protein_40_YDR060W
2 MAK21: Constituent of 66S pre-ribosomal particles, T[GAY].G[KVD]
30 subunit
[SAG]GGTG[SA]G
TUBULIN
in nuclear
PATTERN
export of pre-ribosomes; required
Helicase_C
-0.9 of cytoplasm
human CAATT-binding
organization
0.006
10
oshea_nucleolus
2 oshea_nucleolus
TG[SLG][GIA]K
30 [SAG]GGTG[SA]G
TUBULIN PATTERN
Helicase_C
1.E-09
-0.9
0.005
9
yeast-649_GO-0003676
S..A[NDT]
30
Y
RRM_1
1.E-10
-0.8
0.006
9
matsuyama_Cytosol
2 matsuyama_Cytosol
P..L[RNT]
30
Y
Pkinase
1.E-02
-0.8
ATP binding (1e-11)
Y
0.008
9
protein_40_YLR293C
K[SDE]..S[NQK]
30 of nuclear
S..S organization,Casien
RNA processing
kinase Iand
phosphorylation
transport; regulated
site,by
1st
Prp20p,
SerIBN_N
must
Rna1p,
be Yrb1p,
phosphorylated
Yrb2p,
1.E-07
Yrp4p, Yrb30p,
-0.7 Cse1p
nuclear
and Kap95p;
transport
yeast(1e-08)
Gsp2p homolog
0.006
10
yeast-304_GO-0019752
2 carboxylic acid metabolism
F..[APH]K
30
tRNA-synt_2b
1.E-02
-0.6
Y
0.006
10
protein_40_YOL133W
[EQL]S..S[LDC]
30(SCF);
S..S
required for Gic2p,Casien
Far1p, Sic1p
kinase
and
I phosphorylation
Cln2p degradation;site,
may1st
tether
SerCdc34p
F-box
must be
(a ubiquitin
phosphorylated
1.E-04
conjugating enzyme
-0.6 or E2)
catabolism
and Cdc53p(1e-08)
(a cullin) subunits of SCF
Y
0.006
10
protein_40_YMR128W
2 ECM16: Essential DEAH-box ATP-dependent RNA helicase
R.M[KRM]
30 predominantly nucleolar in distribution, required for 18S rRNA synthesis WD40
1.E-05
-0.6
Y
0.006
10
protein_40_YLR129W
2 DIP2: Nucleolar protein, specifically associated withSD.[EVG][ENL]
SD.E
complex
Casein
known
kinase
as the IIsmall
substrate
subunitmotif
(SSU) processome,WD40
1.E-06
biogenesis,-0.6
part of the
rRNA
activeprocessing
pre-rRNA processing
(1e-24)complex
0.006
10
protein_40_YFL037W
[KED]L.E[DIT]
Y
IBN_N
1.E-02
-0.6
0.006
10
yeast-304_GO-0006082
2 organic acid metabolism
F..[APH]K
30
tRNA-synt_2b
1.E-02
-0.5
Y
0.006
10
yeast-256_GO-0016462
T..I[DPL]
30 T..I
FHA domain bind this ligand in Chk2
ABC_tran
1.E-08
-0.4
Y
0.007
10
yeast-295_GO-0016192
S[KYQ]L
Adaptin_N
1.E-09
-0.2
Y
0.006
9
yeast-295_GO-0016192
NS[ISV]
30 RRR[RN]SII[FD]PKA kinase substrate motif
Adaptin_N
1.E-03
-0.2
0.007
10
protein_40_YLR129W
2 DIP2: Nucleolar protein, specifically associated with theK..K[LET]
U3 snoRNA, part of the large
1.E-05
biogenesis,-0.2
part of the
rRNA
activeprocessing
pre-rRNA processing
(1e-45)complex
0.006
9
yeast-462_GO-0019222
E..R
30
Zn_clus
1.E-07
-0.1
Y
0.006
10
protein_40_YDL014W
2 NOP1: Nucleolar protein, component of the small subunitSE[SKQ]
30 is required
KEESEK
for processing
14-3-3
of pre-18S
gamma,
rRNA;
epsilon
has similarity
nonphosphorylated
toYmammalian
Helicase_C
fibrillarin
binding motif in Ammodytoxin
1.E-04
C,0not confirmed
nucleolus (1e-43)
0.005
10
yeast-413_GO-0005215
V[KFL]T[RVY]
30 FTYP
Docking motif on c-Fos for Erk Y
Mito_carr
1.E-09
0.1
Y
0.007
10
yeast-256_GO-0016462
K.[LVI]A
30
Helicase_C
1.E-19
0.1
Y
0.007
9
protein_40_YOL139C
2 CDC33: Cytoplasmic mRNA cap binding protein; theR[KDA]..[TMA]K
0.1 or Tif4632p)
0.006
8
protein_40_YKL101W
2 HSL1: Nim1p-related protein kinase that regulates the morphogenesis
E[NEA]A and septin checkpoints;
30 KENassociates withLIG_APCC_KENbox_2
the assembled septin filament; required along with
DnaJ_C
Hsl7p for bud neck
1.E-02
recruitment, phosphorylation,
0.1
and degradation of Swe1p
Y
0.006
10
protein_40_YDR449C
VG.[RTH][VFD]
WD40
1.E-03
0.1
nucleolus (1e-13)
0.005
10
protein_40_YDR388W
2 RVS167: Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p)
I[PKA]P
involved
30 in regulation
YIPP of actin cytoskeleton,
AT(1) receptor
endocytosis,
motif necessary
and viabilityfor
following
activation
starvation
Pkinase
of Jak/Stat
or osmotic
pathway
stress;
1.E-03
homolog of0.1
mammalian
cellamphiphysin
cortex (1e-06)
Y
0.005
7
yeast-628_GO-0043037
2 translation
GK[KRY]
30 G[KR][KR]
Amidation after cleavage after Gly (must
HGTP_anticodon
be in secretory pathway)
1.E-03
0.2
translation (1e-14)
0.007
10
oshea_bud_neck
2 oshea_bud_neck
I..E[TKM]
30
RhoGAP
1.E-05
0.2
Y
0.006
9
protein_40_YJL010C
2 NOP9: Essential component of pre-40S ribosomes thatSA[LIF][QR]
30 of 35S
[RK].PNS[AR].R
pre-rRNA and hence
RIBOSOMAL_S12
formation of 18SPATTERN
rRNA; binds RNA in vitro and
WD40
0.3
nucleolus (1e-13)
Y
0.005
8
protein_40_YGR252W
2 GCN5: Histone acetyltransferase, acetylates N-terminalAA[AHR]
30 H3; [LIV]..[LM]L.AA.[FY][LI]
ADA and SAGA histone acetyltransferase complexes;
Histone
founding member
1.E-02
0.4
SAGA
N-acetyltransferase
complex (1e-15)
superfamily
0.006
10
yeast-596_GO-0044425
2 membrane part
I[GLV]A
30
Adaptin_N
1.E-05
0.5
Y
0.006
9
yeast-256_GO-0016462
E.[YDG]R
30 [AG]R
Helicase_C
1.E-12
0.5
Y
0.007
9
matsuyama_ER
2 matsuyama_ER
M.F
30 Y[GD][WH]M[DR]F
GASTRIN PATTERN
MFS_1
1.E-02
0.6
nuclear envelope-endoplasmic reticulum network (1e-23)Y
0.007
10
oshea_bud_neck
2 oshea_bud_neck
[INP]E..L[VYH]
30
RhoGAP
1.E-02
0.7
bud (1e-20)
0.007
9
protein_40_YPL126W
2 NAN1: U3 snoRNP protein, component of the small [IHF]K.[WEF]D
30 [VILAFP]K.E
Motif recognized
required forfor
themodification
biogenesis of18S
by SUMO-1
rRNA WD40
1.E-05
0.8
0.006
10
protein_40_YJR002W
2 MPP10: Component of the SSU processome, which is required
KK[LVD]
interacts with and
Insulin
controls
receptor
the stability
kinase
of Imp3p
substrate
and Imp4p,
motif essential
WD40
1.E-04
to human Mpp10p
0.8
Y
0.006
10
yeast-980_GO-0051179
2 localization
LY[RTG][GAK]
30 Y[AGSTDE]
Src kinase substrate motif
Mito_carr
1.E-13
0.9
0.006
10
protein_40_YPR103W
2 PRE2: Beta 5 subunit of the 20S proteasome, responsible
[GHA]V..[LG]I
Proteasome
1.E-21
0.9
proteasome core complex (sensu Eukaryota) (1e-23) Y
0.006
9
protein_40_YPL153C
2 RAD53: Protein kinase, required for cell-cycle arrest in R..[GED]D
activated
R..[PA]DG
LIG_TNKBMLIG_TNKBM
1.E-02with ARS1
1.1and plays
cellacycle
role in (0.01)
initiation of DNA replication
Y
0.006
9
protein_40_YMR308C
2 PSE1: Karyopherin/importin that interacts with the nuclear
A[NVR]..A
30nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p,
Proteasome
and Aft1p
1.E-02
1.1
proteasome core complex, alpha-subunit complex (sensu Eukaryota) (0.001)
0.006
10
protein_40_YMR047C
2 NUP116: Subunit of the nuclear pore complex (NPC) thatI..[AVY]Q
with karyopherin
1.1
Kap95p;nuclear
homologous
transport
to Nup100p
(1e-18)
0.006
10
protein_40_YGL245W
2 GUS1: Glutamyl-tRNA synthetase (GluRS), forms a complex
P[LPH]K
synthetase
P..P.K
(Mes1p) and Arc1p;
SH3complex
bindingformation
motif forincreases
Crk, general
the catalytic efficiency
Pkinase
of both tRNA1.E-10
synthetases and
1.2
ensuresprotein
their correct
kinase
localization
activity
to the
(1e-10)
cytoplasm
0.006
10
protein_40_YMR047C
L..V[AES]
with karyopherin
1.3
transport (1e-28)
Y
0.006
10
protein_40_YLR074C
2 BUD20: Protein involved in bud-site selection; diploid mutants
S[IR].NSF
display a random budding
30 pattern
R..SFF
instead of thePhosphorylase
wild-type bipolarkinase
pattern phosphorylation site Histone
1.3
0.004
8
protein_40_YER082C
D[IVY][SDF]F
WD40
1.E-04
1.3
0.006
10
yeast-939_GO-0051234
Q.[LQF]S
30
Adaptin_N
1.E-02
1.4
Y
0.006
9
protein_40_YMR047C
2 NUP116: Subunit of the nuclear pore complex (NPC)L[VAD]..[TEP]L
of the pore; contains a repetitive GLFG motif that interacts with Y
mRNA exportIBN_N
with karyopherin
1.4
Kap95p;nuclear
homologous
pore
to (1e-15)
Nup100p
Y
0.006
9
protein_40_YBR159W
G[GLF]F
30 E.IYG.F
cSrc kinase
mutantsphosphorylation
exhibit reduced VLCFA
site synthesis, accumulate
MFS_1 high levels
1.E-06
1.4
transporter
phytosphingosine
activity
and medium-chain
(1e-11)
ceramides
Y
0.006
9
yeast-358_GO-0044248
2 cellular catabolism
G.A[TAE]
30 [ED].D[ST]EG.A[LI]
Motif in sodium channel that binds ankIryn
Proteasome
G
1.E-06
1.5
cellular catabolism (1e-12)
0.006
10
protein_40_YNL031C
2 HHT2: One of two identical histone H3 proteins (seeLQ.[AMW][IAK]
1.5
methylation,
nuclear chromatin
(1e-07)
0.006
10
yeast-1340_GO-0044267
2 cellular protein metabolism
[DCF]D..[FHM]G
30
Y
Ribosomal_60s
1.E-07
1.6
0.006
9
protein_40_YOL133W
[KSR]L..[KFV]N
conjugating enzyme
1.6 or E2)
protein
and Cdc53p
catabolism
(a cullin)(0.001)
subunits of SCF
0.006
9
protein_40_YCL059C
G.K[VKG]
Helicase_C
1.E-02
1.6
0.006
10
matsuyama_Cytosol
2 matsuyama_Cytosol
[GTS][LSF]FD
30 LFDLM
Binding motif in Clint for clathrin Y
TD domain
Ribosomal_60s
1.E-07
1.6
0.008
10
protein_40_YKL021C
2 MAK11: Protein involved in an early, nucleolar step ofKT[LNE][ARM]
30 essential
[RDH][LY][LM][KA]T[QLMEV][KLIR]
for cell growth
FHAand
domain
replication
binding
of killer
motif
M1 dsRNA virus; contains
DEAD
1.E-04
repeats
1.7
0.005
8
2 matsuyama_Microtubule
[NRV]KS[LFR]
30
Kinesin
1.E-03
1.7
0.008
9
yeast-238_GO-0017111
E[TQD].[KMV]R
30 [KR]R
CLV_PCSK_KEX2_1
ABC_tran
1.E-03
1.8
Y
0.007
10
yeast-413_GO-0005215
Y.G[VLW]
30 E.Y.[QSG]
Mito_carr
1.E-27
1.9
Y
0.006
10
protein_40_YDL153C
EN[ICV][LIV]
30for pre-18S
YEN[FIV]
rRNa processing;
SH2essential
ligand for
nucleolar
Tns (Tyr
protein
must
that,
bewhen
phosphorylated)
overproduced,
Pkinase
disrupts silencing
1.E-14
2.1
0.006
8
matsuyama_Cytosol
2 matsuyama_Cytosol
H..[VFE]V
30
Pkinase
1.E-02
2.1
Y
0.007
9
protein_40_YMR047C
2 NUP116: Subunit of the nuclear pore complex (NPC) thatF.[SAT]Q
of the [ST]Q
ATM kinase
GLFG motif
phosphorylation
that interacts with
sitemRNA exportIBN_N
with karyopherin
2.2
Kap95p;protein
homologous
import
to Nup100p
0.006
10
yeast-324_GO-0030528
M..[EAD]E
30 M..E
Motif for targeting Arf1 to Golgi
Zn_clus
1.E-02
2.3
0.007
10
yeast-207_GO-0006974
[IQA]ID
30 RRR[RN]SII[FD]PKA kinase substrate motif
BRCT
1.E-02
2.3
Y
0.007
10
protein_40_YIL019W
2 FAF1: Protein required for pre-rRNA processing andA[TKV]..[YHA]D
30
Y
WD40
1.E-04
2.4
Y
0.005
8
yeast-1547_GO-0043283
PG[TWR][GEF]
30
AAA
1.E-02
2.5
0.006
9
yeast-513_GO-0005515
protein_40_YKR081C
protein_40_YGR128C
yeast-217_GO-0007046
protein_40_YHR030C
yeast-685_GO-0016740
protein_40_YBL007C
yeast-706_GO-0043412
protein_40_YOR272W
protein_40_YKL166C
yeast-565_GO-0006464
yeast-335_GO-0016772
yeast-942_GO-0043228
yeast-942_GO-0043232
yeast-1389_GO-0044260
yeast-1340_GO-0044267
yeast-324_GO-0030528
yeast-324_GO-0030528
yeast-1974_GO-0005634
yeast-939_GO-0051234
yeast-856_GO-0009059
yeast-856_GO-0009059
yeast-752_GO-0016787
yeast-596_GO-0044425
yeast-589_GO-0050896
yeast-513_GO-0005515
yeast-513_GO-0005515
yeast-504_GO-0006350
yeast-470_GO-0006259
yeast-457_GO-0007001
yeast-424_GO-0006950
yeast-413_GO-0005215
yeast-388_GO-0007275
yeast-376_GO-0019219
yeast-371_GO-0009056
yeast-358_GO-0044248
yeast-345_GO-0006396
yeast-284_GO-0005740
yeast-267_GO-0000003
yeast-262_GO-0031224
yeast-244_GO-0000279
yeast-244_GO-0000279
yeast-244_GO-0000279
yeast-238_GO-0017111
yeast-217_GO-0007046
yeast-215_GO-0007010
yeast-213_GO-0009719
yeast-212_GO-0045045
yeast-207_GO-0006974
yeast-203_GO-0005975
yeast-201_GO-0050876
yeast-201_GO-0048610
protein_40_YPR144C
protein_40_YPR120C
protein_40_YPR110C
protein_40_YPR010C
protein_40_YPL240C
protein_40_YPL240C
protein_40_YPL240C
protein_40_YPL213W
protein_40_YPL153C
protein_40_YPL146C
protein_40_YPL129W
protein_40_YPL042C
protein_40_YPL004C
protein_40_YPL004C
protein_40_YOR326W
protein_40_YOR326W
protein_40_YOR312C
protein_40_YOR294W
protein_40_YOR294W
protein_40_YOR206W
protein_40_YOR174W
protein_40_YOR174W
protein_40_YOR133W
protein_40_YOL127W
protein_40_YOL004W
protein_40_YNR054C
protein_40_YNL289W
protein_40_YNL289W
protein_40_YNL289W
protein_40_YNL154C
protein_40_YNL154C
protein_40_YNL118C
protein_40_YNL055C
protein_40_YMR186W
protein_40_YMR116C
protein_40_YMR047C
protein_40_YMR012W
protein_40_YMR001C
protein_40_YMR001C
protein_40_YML010W
protein_40_YML010W
protein_40_YLR429W
protein_40_YLR423C
protein_40_YLR276C
protein_40_YLR180W
protein_40_YLR180W
protein_40_YJR145C
protein_40_YJL177W
protein_40_YJL164C
protein_40_YJL117W
protein_40_YJL106W
protein_40_YJL106W
protein_40_YJL095W
protein_40_YJL092W
protein_40_YJL092W
protein_40_YJL074C
protein_40_YIL133C
protein_40_YIL094C
protein_40_YIL094C
protein_40_YIL075C
protein_40_YIL035C
protein_40_YHR197W
protein_40_YHR196W
protein_40_YHR169W
protein_40_YHR082C
protein_40_YHR030C
protein_40_YHL007C
protein_40_YGR274C
protein_40_YGR245C
protein_40_YGR218W
protein_40_YGR218W
protein_40_YGR218W
protein_40_YGR218W
protein_40_YGR103W
protein_40_YGR086C
protein_40_YGR086C
protein_40_YGR040W
protein_40_YGR040W
protein_40_YGR040W
protein_40_YGR034W
protein_40_YGL207W
protein_40_YGL103W
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
E..L[RKA]
30
IBN_N
1.E-04
2.6
Y
0.006
10
0.006
10
Y
0.005
10
A[LDI][DRI]L
30 DALDL
DEAD
1.E-06
3
0.006
8
E[YRP]..G[GRS]
wall integrity
G[FL]PGER..G
and progression
LIG_IBS_1LIG_IBS_1
through the cell cycle; regulated by the PKC1-mediated
1.E-03
3.2
kinase activity (0.001)
0.005
8
[FYG]G[KYT]V
30 FRGGT
Phosphoinositide binding motif in ATG18 and
Pkinase
ATG21
1.E-10
3.3
Y
(1e-21)0.007
10
SLA1: Cytoskeletal protein binding protein required for assembly
DFG[LIM]
of the cortical actin
30cytoskeleton; interacts with proteins regulating actin dynamics and proteinsPkinase
required for endocytosis;
1.E-10
found in the
3.3nucleusprotein
and cellkinase
cortex; has
activity
3 SH3(1e-10)
domains
0.004
8
Y[RMC][AKH]P
30
Pkinase
1.E-14
3.4
0.007
10
A[TH].GRF
30 ribosomal
[AG]Rsubunit
Y
DEAD
1.E-04
3.4
0.004
8
R[DFW].K[PIC]
30 in response to nutrients via the Ras-cAMP signaling pathway;Yinhibited byPkinase
1.E-10
in the absence
3.6 of cAMP;
protein
partially
kinase
redundant
activity
with(1e-10)
Tpk1p and Tpk2p
0.006
10
[MRT]AP[EM]
30 P[TS]AP
LIG_PTAPLIG_PTAP
Pkinase
1.E-22
4
0.007
10
EL[LDF]
Pkinase
1.E-51
4.7
Y
(1e-18)0.007
9
[TND]GS[GTQ]K
30 S[ST]
Y
DEAD
1.E-14
5.1
0.007
10
[TND]GS[GTQ]K
30 S[ST]
Y
DEAD
1.E-14
5.2
0.007
10
K[PTQ].N[ILK]L
30
Pkinase
1.E-33
5.6
0.007
10
KP.N[ILF][LMD]
30
Pkinase
1.E-43
5.7
0.006
9
FSR[SIH][DYN]
30 RR.SR
SRPK2 kinase phosphorylation site (peptide
zf-C2H2
screen)
1.E-14
6.4
0.006
9
L.[RQT]H
30
Y
zf-C2H2
1.E-33
9.5
0.006
9
nucleus
C.[NIY]C
30 C..C
Zn_clus
1.E-12
16.4
0.006
9
TG.[VLA][EMS]
30 TGY
ERK6/SAPK3 activation sites forYHOG/p38 activation
0.007
10
D[KDS]N
30 Y.D.NHKPE
PMI_I_1 PATTERN
0.006
10
S[PNL]T
30 PTL
Motif in Fos for proteosome degredation
0.006
10
hydrolase activity
S[NYF]A[VKI]
30
Y
0.006
9
membrane part
IG..[GWF][DAI]
30
Y
0.007
9
D.[LRM]G
30 D..G
motif that binds phosphate in GDP and GTP binding proteins
0.006
10
protein binding
[RAT]I..F[FKT]
30
0.006
9
protein binding
PP.[PMD][PGQ]A
30 PPR
LIG_WW_3LIG_WW_3
0.006
8
transcription
A[QVS]..A[QGP]A
30
0.007
9
DNA metabolism
Q[EDF][NGW]KK
30
Y
0.006
9
L[LTK]..[QHM]Q
30
10
response to stress
[PLD]E.P[KMG]
30
0.007
10
N..K[NRK]
30 KR
CLV_PCSK_PC1ET2_1
0.006
10
development
K[KTM].[TQG]G
30
Y
0.007
9
regulation of nucleobase, nucleoside, nucleotide and
KL.N[AHM][TLH]
30
0.007 (1e-12)9
catabolism
[AGF]A..G[FYE]
30
catabolism (1e-36)
0.006
10
cellular catabolism
[LVC]E.[SQV]G
30
0.006
9
RNA processing
KN..[LSD]I[GMY]
30 IY
0.006
10
L[LFQ]Q
30 DLL
Binding motif for clathrin heavy chain ear
0.006
10
reproduction
[LNT][LIT].VN
30 YVNI
SH2 ligand for Grb2
0.007
10
I[FYN]F
30 D..SII.FF
CK I delta kinase phosphorylation
Y site (peptide screen)
0.006
9
M phase
[LAS]I[RMF]E
30 IYE
cFPS/FES kinase phosphorylation site (peptide screen)
M phase (1e-48)
Y
0.007
9
M phase
[QT]D.L[VFH]
30 DLL
M phase (1e-32)
0.007
10
M phase
T[LCM]Q[FGM]
30
M phase (1e-25)
0.007
10
[GAQ]TL[TGR]
30 PTL
Y
0.007
10
ribosome biogenesis
[EKQ]D.L[LFD]T
30 DLL
0.006
8
[INY]..LR
30 Y..L
Motif for down regulation of the CD46 receptor
Y
0.006
10
[NYM]Q.[ESQ]A
30
0.007
10
secretory pathway
[ESC]N.IK[SLD]
30
Y
0.005
9
[LEA]D.[DRN]L
30 D..LL
Di-Leu motif for receptor endocytosis (recognized by VHS domain of GGA proteins)response to DNA damage stimulus (1e-57)
Y
0.006
9
carbohydrate metabolism
F..D[TYG]
30
carbohydrate metabolism (1e-87)
0.006
10
reproductive physiological process
VN..[RVA][NLT]
30
reproductive physiological process (1e-42)
0.007
10
reproductive cellular physiological process
VN..[RVA][NLT]
30
reproductive physiological process (1e-42)
0.007
10
RG..[SK]K[IY]
and nuclear
RGDexport of 40S ribosomal
LIG_RGDLIG_RGD
subunits
0.004
7
CLB5: B-type cyclin involved in DNA replication during SK.[NQA]S
Y
0.005
10
RPC40: RNA polymerase subunit, common to RNA T[PQW][QVE]E
30 [PSAT].[QE]E LIG_TRAF2_1
0.006
10
RPA135: RNA polymerase I subunit A135
RA.[FE]E[EL]
30
0.004
8
N..[KIP]V
0.005
10
N..[NEI]T
0.005
10
S.V[LNG]
30of Hsf1p;
KKKLPATGDYMNMSPVGD
docks with Tom70p
Insulin
for receptor
mitochondrial
kinase
preprotein
substrate
delivery;
Ymotif
promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
0.006
10
LEA1: Component of U2 snRNP; disruption causes[FRM][SHQ]..ED
reduced U2 snRNP levels; physically
30 EED
interacts with Msl1p;Ankyrin
invovledBinC-terminal
telomere maintenance;
motif that binds
putativeinternal
homolog
Ankyrin
of human
repeats
U2A' snRNP protein
0.005
9
RAD53: Protein kinase, required for cell-cycle arrest in K..[ILMV]T
Y
Y
0.006
10
NOP53: Nucleolar protein; involved in biogenesis ofD[RTE]..[EGM]E
Y
0.006
10
TAF14: Subunit of TFIID, TFIIF, INO80, SWI/SNF, and
ED.[EV][NVG]
in RNA SEDEE
CKII kinase
initiation
phosphorylation
and in chromatinsite
modification;
(peptidecontains
screen)a YEATS domain
0.006
10
SSN3: Cyclin-dependent protein kinase, component[KLM]N.S[SAT]
of RNA polymerase II holoenzyme;
30 involved
S[ST] in phosphorylation
MDC1ofBRCT
the RNA
domain
polymerase
binding
II C-terminal
motif
Y
domain; involved in glucose repression
0.006
10
[RTK]AE[ANC]
0.005
9
LSP1: Primary component of eisosomes, which are Y[PNR]..[PYA]S
large immobile patch structures
Y
0.005
8
MYO2: One of two type V myosin motors (along withEL[LAH][TQV]
0.006
10
MYO2: One of two type V myosin motors (along withK[PYC].E[PRL]
Y
0.005
10
R..[RAY]A
to Rpl20Ap and has similarity to rat L18a ribosomal protein
Y
0.006
10
RRS1: Essential protein that binds ribosomal protein
[DLS]E..D[KQC]
30export[ST]E
G protein-coupled
subunit duringreceptor
ribosome kinase
biogenesis;
1 substrate
mouse homolog
motif shows altered expression in Huntington's
ribosome
disease
biogenesis
model mice(1e-07)
Y
0.006
10
RRS1: Essential protein that binds ribosomal protein L11EE[ELD]
and is required for nuclear
30exportEE[DE]IYFFFF
CSK kinase
subunitsubstrate
during ribosome
motif biogenesis; mouse homolog shows altered expression in Huntington's
nucleolus
disease
(1e-14)
model mice
0.006
10
[AGF]T.[KVG]K
66S pre-ribosomes,
[KG][AG][TID].[PVLS]K.[KR][HY]
as wellPI(4,5)P2
as a nuclear
binding
complex
motif
with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear
cytoplasm
transport
organization
of ribosomal
and
precursors
biogenesis (1e-08)
0.006
10
[NEV]S[TGM]N
30 S[ST]
subunits to formMDC1
the RNA
BRCT
polymerase
domain
II holoenzyme;
binding motif
essential for transcriptional regulation
0.006
10
MED4: Subunit of the RNA polymerase II mediator [QDP]Q..[QYA]N
30
0.005
9
AA[LGW]
30 [LIV]..[LM]L.AA.[FY][LI]
contains diphthamide, the unique posttranslationally modified histidine residue specifically
translation
ADP-ribosylated
elongation
by diphtheria
factor
toxin
activity (0.001)
0.006
10
S..[LFY]L
30 subunit,
S..F has similarity
LIG_BRCT_BRCA1_1
to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
0.005
10
SIN3: Component of the Sin3p-Rpd3p histone deacetylase
[GVK]S..[AM]R
30 [AG]R
repression andProtease
activation matriptase
of diverse processes,
proteaseincluding
site
mating-type switching and meiosis; involved in the maintenance
transcription
of chromosomal
(0.01)
integrity
0.004
7
ESF2: Essential nucleolar protein involved in pre-18S
[KFQ]I.[RNK]V
30of the small subunit (SSU) processome; has sequence similarity
Y to mABT1, a mouse transcription activator
nucleolus (1e-11)
0.005
10
[DES]FN[NIT]
0.006
8
PCL1: Pho85 cyclin of the Pcl1,2-like subfamily, involvedD.D[TFI]
30cycleD.D
Ribose moietylocalizes
of UDPtoand
sitesmanganese
of polarized cell
binding
growthsite in glucuronyl transferase
Y
0.005
9
ET..[FMW][GPI]
0.006
9
YCK2: Palmitoylated, plasma membrane-bound casein E..[VTE]P
30
Y
0.006
10
L.K[TED]
30 G[SA]LNK
GDP-mannose
in morphogenesis,
binding
proper
motif
septin
in assembly,
transporter
endocytic trafficking; provides an essential function overlapping with that of Yck1p
Y
0.005
10
[KDI]I.K[TFA]
30
0.006
10
POR1: Mitochondrial porin (voltage-dependent anionT[SMQ].D[GH]
30 required
S.D for the maintenance
CAMKIIofphosphorylation
mitochondrial osmotic
site stability and mitochondrial membrane permeability; phosphorylated
0.004
7
HSC82: Cytoplasmic chaperone of the Hsp90 family, redundant
GV[ELI]
in function and nearly
30 identical
E.IYGVLF
with Hsp82p, and
Lcktogether
kinase they
substrate
are essential;
motif expressed
Y constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
0.006
10
[VGR]E.[AIV]G
30 ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
0.005
9
NUP116: Subunit of the nuclear pore complex (NPC)T[ALT].T[KFQ]
of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p;protein
homologous
import
to Nup100p
Y
0.006
9
GK..[LGM][ELM]
0.006
9
[TLD]D..[NID]S
cohesin
be a Cdc28p
complex
substrate
(1e-05)
0.006
10
CDC5: Polo-like kinase with similarity to Xenopus Plx1 and
T..N[LEG]
S. pombe Plo1p; found30
mitosis
be a Cdc28p
(1e-04)
substrate
0.006
10
E..N[AIK]
30
0.005
7
V[IKY][NQD]L
30
Y
0.006
9
V..K[EGI]
30
cortical cytoskeleton (0.01)
0.006
9
[LHQ]E.[KC]R
30interacts
KRwith and is required
CLV_PCSK_PC1ET2_1
for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway
0.005
8
DBP9: ATP-dependent RNA helicase of the DEAD-box
R[EKQ][LEV]A
0.006
8
SAM1: S-adenosylmethionine synthetase, catalyzes[TMQ]G[FNR]K
of ATPG[KR][KR]
Amidation
methionine;
after
one cleavage
after Glyregulated
(must be
isozymes
in secretory
(Sam1ppathway)
and Sam2p)
0.005
9
Y[EPF]A
0.006
10
RPS4A: Protein component of the small (40S) ribosomalE..[AG]E
Y
0.006
10
K[GVA].K[VAY]
Y
0.006
10
TPK1: cAMP-dependent protein kinase catalytic subunit;S[DKS]Q
30 in response
[ST]Q to nutrients ATM
via thekinase
Ras-cAMP
phosphorylation
signaling pathway;
site inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p
0.005
9
PHO86: Endoplasmic reticulum (ER) resident protein required
II.[TIQ][IVH]
for ER exit of the high-affinity
30
phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles
0.006
10
[GHS][SVP].SE
with Ime1p
[ST]E
and mediates its
G stability,
protein-coupled
activates Ndt80p;
receptor
IME2
kinase
expression
1 substrate
is positively
motifregulated by Ime1p
0.006
10
[KFR][SNG].KKN
with Ime1p and mediates its stability, activates Ndt80p; IME2 expression
Y
is positively regulated by Ime1p
0.004
7
[TMS][EDG]..AS
0.006
10
K[ALT]L
for proper
K[AI][CL]SGK[FI].[PQ]
UBIQUITIN_ACTIVAT_1
PATTERN
and transition from Meiosis I to II; affects genome stability by suppressing
response
unscheduled
to DNA damage
homologous
stimulus
recombination
(1e-05)
Y
0.005
10
LK.[SQC]
0.005
10
AI.[DFR][GVI]
30 EDAIY
in mitotic cells; alsoAbl
required,
kinasewith
substrate
Rec8p, for
motif
cohesion and recombination during meiosis; phylogenetically conserved
cohesin
SMC chromosomal
complex (0.001)
0.006
10
A.[GKA]K
30 VPGKARKKSSCQLL
has similarity to Rpl16Bp,protein
E. coli L13
kinase
and rat
IV L13a
substrate
ribosomal
motifproteins; transcriptionally regulated
cytosolic
by Rap1p
Y
0.006
10
[LIE]E.[GVL]T
Y
0.006
10
V[DGN].[AET]L
Y
0.006
10
RPN2: Subunit of the 26S proteasome, substrate of the
[FTD][LQW]IE
N-acetyltransferase Nat1p30
0.006
10
E[TGQ]S[DIR]
RNA polymerase
factors and allIIRNA
transcription
polymeraseselongation factor activity (1e-08)
0.006
9
KR..[VEF][EKG]
30for processing
KR
of ITS2 sequences
CLV_PCSK_PC1ET2_1
from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
0.006
10
[PMQ]V.K[LRW]
30 the
KRU3 snoRNA that isCLV_PCSK_PC1ET2_1
0.005
9
DBP8: Putative ATP-dependent RNA helicase of the DEAD-box
G..G[ERF]
family involved in 30
biogenesis
G.G..G
Phosphate,
subunit FAD, NADH, binding motif
ribosome (0.01)
0.006
9
V..[RVP]G
0.006
9
AG[GKH][SQY]
wall integrity
GGQand progression
N-methylation
through the cell
motif
cycle;
in regulated
E. coli, Gln
by the
residue
PKC1-mediated
in methylated,
signaling
mimics
pathway
CCA motif at the end of tRNA molecule
0.005
10
K.G[DQM]
30in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases
0.005
10
Y[SL]S[IN]L
30 has R.Y.S
14-3-3
activity,
binding
involved
motifin(Ser
promoter
must binding
be
Y phosphorylated)
and G1/S progression
0.003
8
SDA1: Highly conserved nuclear protein required for
VK..[SMW][KGW]
30and passage
K..[ST]through Start,
PKA
plays
kinase
a critical
substrate
role in G1
motif
events, binds Nap1p, also involved in 60S ribosome biogenesis
Y
0.005
8
A[EAV][KSD]N
30 from the nucleus
Y
0.006
10
EI[KEM][SMW]
30 from
VEID
the nucleus
0.006
10
LA.[PTD][DIE]
30 from the nucleus
0.006
10
Q..[PNQ]S
30 from the nucleus
Y
0.005
9
KA..[ESI][LDF]
30
cytoplasm
cell proliferation
0.006
9
K[NVG][SDL]G
30 associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated
SWR1 complex
state in(1e-04)
mitochondria
0.006
10
PIL1: Primary component of eisosomes, which are largeP.P[KQN]
30 associated
P.P
with endocytosis;
motif innull
interleukin
mutants show
5 receptor
activation
necessary
of Pkc1p/Ypk1p
for signaling
stress resistance pathways; detected in phosphorylated
SWR1 complex
state in(0.001)
mitochondria
0.006
10
[EGM]D.[ENG]T
30 D.E
Sec24pSec24pSec24p
growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
0.006
9
A[PDK]..[KAG]E
30
0.006
9
V[ETV]..[STF]K
30
0.006
10
[KEH][IKL]RA
to Rpl26Ap
[KR]R
and has similarity
CLV_PCSK_KEX2_1
to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
0.006
9
SPT16: Subunit of the heterodimeric FACT complex[RKY]K.[LQF]R
30Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure
RNA polymerase II transcription elongation factor activity (1e-09)
0.006
8
RPL28: Ribosomal protein of the large (60S) ribosomal
R[VDR].[RDA]R
coli L15
[KR]R
CLV_PCSK_KEX2_1
proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance cytosolic ribosome (sensu Eukaryota) (1e-19)
0.006
10
protein binding
RPF2: Essential protein involved in the processing ofR[EKQ][LIE]A
of the 60S
MR[DE][IL]
ribosomal subunit;
TUBULIN_B_AUTOREG
interacts with ribosomal protein
PATTERN
L11; localizes predominantly
DEAD
to the 1.E-05
2.8 of 66S
nucleolus
pre-ribosomal
(1e-15)
particles
UTP8: Nucleolar protein required for export of tRNAsVK[ILH][WIR]
1.E-06
of pre-18S2.8
rRNA
ribosome biogenesis
protein_40_YGL048C
[VPG]D.[LER]A
30 D.E
in the degradation ofSec24pSec24pSec24p
ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainlyproteasome
complex the
(sensu
cell cycle
Eukaryota) (1e-09)
0.006
protein_40_YFR034C
V[SEA].[AEG]AA
30
with Pho2p to the PHO5 promoter; function is regulated
Y by phosphorylation at multiple sites and by phosphate availability
0.004
protein_40_YFL037W
2 TUB2: Beta-tubulin; associates with alpha-tubulin (Tub1pK[TEA]T
30dimer,
CKPCLK.TC
which polymerizesCLUSTERIN_1
PATTERN
Y
Y
0.006
protein_40_YFL037W
L[QHR]Q[IVN]
30dimer,
Y[MLVIF][PRKH]Q
which polymerizesSTAT3
to form SH2
microtubules
Y
0.005
protein_40_YER177W
2 BMH1: 14-3-3 protein, major isoform; controls proteomeSN[SLG]
30bindsCP[ST]N[ILV]GT
proteins and DNA,GUANIDO_KINASE
involved in regulation ofPATTERN
many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
0.005
protein_40_YER172C
2 BRR2: RNA-dependent ATPase RNA helicase (DEIHL[ERA].E[EQR]
spliceosome (1e-14)
0.006
protein_40_YER118C
2 SHO1: Transmembrane osmosensor, participates inV[RLH].[TRY]S
activation of both the Cdc42p-30
and MAP
R.[FY]S.P
kinase-dependent
14-3-3
filamentous
binding
growth
motifs,
pathway
Ser must
and the
behigh-osmolarity
phosphorylated
glycerol response pathway
0.006
protein_40_YER112W
2 LSM4: Lsm (Like Sm) protein; part of heteroheptameric Q[EAQ]Q
either GQDQTKQQI
43_KD_POSTSYNAPTIC
Lsm1p complex involved
PATTERN
in mRNA decay; nuclear Lsm8p complex part of U6 snRNP andmRNA
possiblymetabolism
(1e-07)tRNA, snoRNA, and rRNA
0.006
protein_40_YER110C
2 KAP123: Karyopherin beta, mediates nuclear import [KP]S.[EHG]G
assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
0.005
protein_40_YER082C
[EDK]E.[IWA]A
Y
0.006
protein_40_YER082C
[VAT]LL[RDH]
30 the
[DE]..LL
U3 snoRNA that isDi-Leu
involved
acidic
in processing
motif forofreceptor
pre-18S rRNA
endocytosis
Y
(recognized by VHS domain of GGA proteins)
0.006
protein_40_YER074W
2 RPS24A: Protein component of the small (40S) ribosomalL..I[LTF]
0.006
protein_40_YER018C
2 SPC25: Component of the evolutionarily conserved DL.[LRS][KMD]
complex
PWDLW
involved in chromosome segregation, spindle checkpoint activity and kinetochore
microtubule
clustering cytoskeleton (0.001)
0.006
protein_40_YER018C
EL[EQR][ELK] Ndc8030
microtubule
clustering cytoskeleton organization and biogenesis (0.01)
0.006
protein_40_YEL037C
V[VSR]D[QPG]
30(with Rad4p)
DVAD during nucleotide
Protease
excision
Caspase
repair; regulates
2 -stringent
Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2);
proteasome
homolog of human
regulatory
HR23Aparticle
and HR23B
(sensu
proteins
Eukaryota) (1e-05)
0.005
protein_40_YDR510W
D[ILT]DA[DIP]
0.005
protein_40_YDR510W
DL[TEG]
30 proteins;
WDL regulates chromatid
Bindingcohesion,
motif forchromosome
AP-2 and clathrin
segregation,
Y heavy
APC-mediated
chain ear proteolysis, DNA replication and septin
protein
ring dynamics
sumoylation (1e-04)
Y
0.005
protein_40_YDR477W
2 SNF1: AMP-activated serine/threonine protein kinase found
R[KPD]N
30Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
0.005
protein_40_YDR449C
G[KNG]..K[LAT]
0.006
protein_40_YDR448W
2 ADA2: Transcription coactivator, component of the ADA
Q[QGY]L[QVC]
adaptor/HAT
YL[VMAY]I
(histone acetyltransferase)
Sorting nexin
complexes
1 (Binding motif), Lysosomal targeting motif in EGFR
0.006
protein_40_YDR447C
2 RPS17B: Ribosomal protein 51 (rp51) of the small (40s)K.[RAK]A
Y
Y
0.006
protein_40_YDR381W
2 YRA1: Nuclear protein that binds to RNA and to Mex67p,Q[ARI]A
30 mRNA from the nucleus; member of the REF (RNA and export
Y factor binding proteins) family; another family member,cytoplasm
Yra2p, can substitute
organization
for Yra1p
and
function
biogenesis (1e-05)
Y
0.005
protein_40_YDR356W
[RKE]KI[LME]
nucleation (1e-15)
manner
0.006
protein_40_YDR328C
2 SKP1: Evolutionarily conserved kinetochore protein that
D[SG]..G[IMR]
30
including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase
0.005
protein_40_YDR328C
2 SKP1: Evolutionarily conserved kinetochore proteinS[STE].[TGD]ID
that is part of multiple protein complexes,
30 S[ST]
including the SCF
MDC1
ubiquitin
BRCT
ligase
domain
complex,
binding
the CBF3
motif
complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase
0.004
protein_40_YDR303C
2 RSC3: Component of the RSC chromatin remodeling[SQD]T..N[GQ]
RSCtocomplex
Rsc30p (1e-07)
0.004
protein_40_YDR303C
2 RSC3: Component of the RSC chromatin remodelingG[VQM]L[PTK]
30 forIYG.L
Lck kinase
ploidy and
phosphorylation
regulation of ribosomal
site (peptide
protein genes
screen)
and the cell wall/stress response; highly similar
chromosome
to Rsc30p organization and biogenesis (sensu Eukaryota)
Y
(0.01) 0.006
protein_40_YDR190C
2 RVB1: Essential protein involved in transcription regulation;
[AFP]N.[PWI]K
component of chromatin
30remodeling complexes; required for assembly and function of Y
the INO80 complex; member of the RUVB-like protein family
0.006
protein_40_YDR145W
[EKC]D.[DSK]D
30 D.D
Ribose
and in
moiety
chromatin
of UDP
modification,
and manganese
similar to histone
binding
H2A
site in glucuronyl transferase
0.006
protein_40_YDR099W
[AHW][KHR].KN
0.005
protein_40_YDR064W
2 RPS13: Protein component of the small (40S) ribosomal
K[GVA].K[VFA]
30coli S15 and rat S13 ribosomal proteins
0.006
protein_40_YDR012W
EA.[AVR][ETH]
Rpl4Ap
IEAD
to E. coli L4Caspase
and rat L410
ribosomal proteins
Y
0.006
protein_40_YCR034W
2 FEN1: Fatty acid elongase, involved in sphingolipid biosynthesis;
W.L[LFQ]
acts on fatty acids
30of upWDL
to 24 carbons in length;
Binding
mutations
motif have
for AP-2
regulatory
and clathrin
effects on
heavy
1,3-beta-glucan
chain earsynthase, vacuolar ATPase, and the secretory
endoplasmic
pathwayreticulum (0.001)
0.006
protein_40_YBR198C
[TGA]Q[QNY]Q
30 II transcription
[ST]Q initiation and
ATMin kinase
chromatin
phosphorylation
modification
site
0.005
protein_40_YBR106W
[EYG]Y..[KNV]Q
30double
[EDY]Y
TC-PTP
enhanced
phosphatase
synthesis of substrate
repressible motif
acid phosphatase at high inorganic phosphate concentrations
basic amino acid transporter activity (0.001)
0.005
protein_40_YBR059C
2 AKL1: Ser-Thr protein kinase, member (with Ark1p and
[SIA]E[DAG]E
Prk1p) of the Ark kinase family;
30 involved
[ST]Ein endocytosisGand
protein-coupled
actin cytoskeleton
receptor
organization
kinase 1 substrate motif
0.006
protein_40_YBR009C
2 HHF1: One of two identical histone H4 proteins (see also
L[QMR]Q
30 forARKGSLRQ
chromatin assembly
PKC
and alpha
chromosome
kinasefunction;
substrate
contributes
motif to telomeric silencing; N-terminal domain involved in maintaining
DNA metabolism
genomic integrity
(1e-07)
0.006
protein_40_YBR009C
2 HHF1: One of two identical histone H4 proteins (seeQ[KVN]..[LTR]D
0.006
protein_40_YBL004W
2 UTP20: Component of the small-subunit (SSU) processome,
A[QKS]..[KI]E
which is involved in the
30biogenesis of the 18S rRNA
0.006
protein_40_YAL032C
[KWQ]N..R[LKS]
spliceosome
transcription of
(1e-08)
a reporter gene
Y
0.006
protein_40_YAL032C
I..L[TRD]
nuclear
transcription
mRNA
of asplicing,
reporter gene
Y
0.006
protein_40_YAL032C
Q.[VCH]N
Y
0.006
protein_40_YAL032C
T[LTN]P
30 interacts
PLTLP
RAF1Prp22p
kinaseand
substrate
Prp46p; orthologous
motif
nuclear
transcription
mRNA
of asplicing,
reporter gene
Y
0.006
oshea_spindle_pole
2 oshea_spindle_pole
LE..[YLC][REI]
30
0.006
oshea_mitochondrion
L[FIW]L
30
0.006
oshea_Golgi_or_Golgi_to_vacuole
2 oshea_Golgi_or_Golgi_to_vacuole
I.L[IEV]
30 YIDL
SH2 ligand for Syp (also tyr is phosphorylated by the insulin receptor)
Y
0.006
oshea_bud
2 oshea_bud
[AWE][SVE]..PQ
30 HPQ
bud (1e-04)
0.005
NSI[KHS][EGW]
30 RR.SI
PKA kinase phosphorylation site (peptide screen)
spindle (1e-10)
0.006
K[SMR][YEW]L
30 KR
CLV_PCSK_PC1ET2_1
spindle pole (1e-06)
Y
0.008
genetic_YPL055C
E..I[SNM]
30
Y
0.005
genetic_YPL055C
I..[LRQ]Q
diploid null mutant
GoLoco
displays
motif,
delayed
a G premeiotic
alpha binding
DNA synthesis
motif
and reduced efficiency of meiotic nuclear division
Y
(1e-11) 0.006
genetic_YPL055C
L[SQH]T
30 IRRLSTRRR
diploid null mutant
Nekdisplays
2 kinase
delayed
substrate
premeiotic
motifDNA synthesis and reduced efficiency of meiotic nuclear division
Y
0.005
genetic_YPL055C
P.[VLE]D
30 PYVD.[AT].F
diploid null mutant
Tak1
displays
docking
delayed
site inpremeiotic
Tab1 DNAYsynthesis and reduced efficiency of meiotic nuclear division
genetic_YPL055C
2 LGE1: Protein of unknown function; null mutant formsTP.[RYC][KYD]
30 [ST]P
diploid null mutant
LIG_WW_4LIG_WW_4
displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
0.006
genetic_YNL153C
2 GIM3: Subunit of the heterohexameric cochaperone[TYR]K.L[LES]Q
specifically
[ST]Q
ATM kinase
and transfers
phosphorylation
target proteins
site to it
0.005
genetic_YNL153C
2 GIM3: Subunit of the heterohexameric cochaperoneSN.[SWE]I[SIW]
specifically
N.[TS]
N-linkedand
glycosylation
transfers target
siteproteins to it
0.005
genetic_YNL153C
V[QPY]L[NAE]
specifically
P.V.Lto cytosolic chaperonin
Shadow-Chromo
and transfers
domain
target proteins
bindingYtomotif
it
mitosis (0.01)
0.006
genetic_YLR262C
2 YPT6: GTPase, Ras-like GTP binding protein involvedP[LK].A[TIM]
30 for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.006
genetic_YLR262C
2 YPT6: GTPase, Ras-like GTP binding protein involved inR[KDA]K
30 for
L..RR.KK
ERK docking
vesicles
motif
with
in the
RSK
late
stringent
Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity
chromosome
to the human
organization
GTPase, Rab6and biogenesis (sensu Eukaryota)
Y
(1e-16) 0.006
genetic_YLR200W
2 YKE2: Subunit of the heterohexameric Gim/prefoldinS[SKG]ID[GLH]
30folding
S[ST]
MDC1 BRCT
anddomain
actin
binding motif
cytoskeleton-dependent intracellular transport (0.01)
0.005
genetic_YGL058W
L..Q[LWE] repair (with Rad18p),
30
0.006
genetic_YER083C
2 GET2: Subunit of the GET complex; required for meioticE..[ASE]N
30retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function chromosome organization and biogenesis (sensu Eukaryota)
Y
(1e-15) 0.006
genetic_YER083C
2 GET2: Subunit of the GET complex; required for meiotic
HL..[NGP][LMV]
30retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function chromosome organization and biogenesis (sensu Eukaryota) (0.001) 0.006
genetic_YDL020C
2 RPN4: Transcription factor that stimulates expression of R[DKS]K
levels L..RR.KK
are in turn regulatedERK
by the
docking
26S proteasome
motif in RSK
in a negative
stringent
feedback control mechanism; RPN4 is transcriptionally regulated
chromosome
by various
organization
stress responses
yeast-1166_GO-0005488
2 binding
P..P[SPK]
29 [RKY]..P..P
LIG_SH3_1LIG_SH3_1
RRM_1
1.E-05
-2.5
0.006
protein_40_YDR381W
2 YRA1: Nuclear protein that binds to RNA and to Mex67p,R[GVI]G
29 mRNA
FRGGT
from the nucleus;
Phosphoinositide
member of the REF
binding
(RNAmotif
and export
in ATG18
factorand
binding
DEAD
ATG21
proteins) family;
1.E-02
another family
-2.5
member,
RNA
Yra2p,
metabolism
can substitute(1e-04)
for Yra1p function
Y
0.005
protein_40_YPR016C
2 TIF6: Constituent of 66S pre-ribosomal particles, has similarity
Q..[AEK]E
29initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S
Brixribosomal subunits
1.E-04
-2.4
0.005
protein_40_YDR324C
2 UTP4: Nucleolar protein, component of the small subunitE..E[EKV]
29 the
RE..E
U3 snoRNA that isIron
involved
binding
in processing
motif in ferritin
of pre-18S
L-chain
rRNAand yeast
WD40
1.E-04
-2.2
0.005
protein_40_YPL203W
P[QIV][QRN]Q
29 in response to nutrients via the Ras-cAMP signaling pathway; inhibited byPkinase
1.E-04
in the absence
-1.9 of cAMP;
protein
partially
kinase
redundant
activity
with(0.01)
Tpk1p and Tpk3p
0.005
protein_40_YNL272C
[TNS]Q[DEP]K
29cytoplasmic
[ST]Q vesicles; essential
ATM kinase
for post-Golgi
phosphorylation
vesicle transport
site
Pkinase
1.E-12
-1.9
0.005
protein_40_YKR048C
2 NAP1: Protein that interacts with mitotic cyclin Clb2p;
K[ASQ].Q[SVM]
1.E-03
and H2B histones
-1.8 to the
protein
nucleus;
kinase
phosphorylated
activity by
(0.001)
CK2
Y
0.006
protein_40_YER082C
2 UTP7: Nucleolar protein, component of the small subunitV..[TIN]K
WD40
1.E-02
-1.7
0.005
protein_40_YDR099W
AN.[QHT][LQR]
29bindsN.[TS]
proteins and DNA,N-linked
involved inglycosylation
regulation of many
site processes including
Pkinase
transport, Ras/MAPK
-1.5 signaling, and rapamycin-sensitive signaling
0.005
yeast-649_GO-0003676
S[DAN]S[APY]
29
PUF
1.E-03
-1.4
Y
0.006
yeast-215_GO-0007010
2 cytoskeleton organization and biogenesis
P..P[NPT]
29 [RKY]..P..P
LIG_SH3_1LIG_SH3_1
SH3_1
1.E-04
-1.4
0.006
yeast-1433_GO-0006139
DA
29 DALDL
BRCT
1.E-03
-1.4
Y
0.006
protein_40_YKL009W
2 MRT4: Protein involved in mRNA turnover and ribosomeE..E[DAN]
nucleolus
RE..E
Iron binding motif in ferritin L-chain and yeastBrix
1.E-03
-1.4
0.005
protein_40_YDR388W
2 RVS167: Actin-associated protein, subunit of a complexN.[LNQ]P
29 in regulation of actin cytoskeleton, endocytosis, and viability following starvation
Pkinase
or osmotic stress;
1.E-02
homolog of
-1.4
mammalian
cellamphiphysin
cortex (0.01)
0.005
yeast-504_GO-0006350
2 transcription
HT.[EQS]K[PYF]
29
zf-C2H2
1.E-13
-1.2
0.006
yeast-256_GO-0016462
ER.[DKY][EGD]
29
ABC_tran
1.E-06
-1.1
0.007
protein_40_YPL211W
2 NIP7: Nucleolar protein required for 60S ribosome subunit
KA..[EKF][LMD]
DEAD
-1.1
Y
0.006
protein_40_YOR181W
SA..[VAP][PQD]
Y patches; homolog
SH3_1 of the human
1.E-08
Wiskott-Aldrich
-1.1syndrome
actin
protein
cytoskeleton
(WASP)
(1e-04)
0.006
protein_40_YOR181W
2 LAS17: Actin assembly factor, activates the Arp2/3 AS..[VNP][GRA]
SH3_1 of the human
1.E-07
Wiskott-Aldrich
-1.1syndrome
bipolar
protein
bud
(WASP)
site selection (1e-08)
Y
0.006
protein_40_YOR181W
[DKP]QT[SER]
branched
[KR].TQT
LIG_Dynein_DLC8_1
with the Arp2/3 complex to actin patches; homolog
SH3_1 of the human
1.E-02
Wiskott-Aldrich
-1.1syndrome
actin
protein
cytoskeleton
(WASP)
organization and biogenesis (1e-06) Y
0.005
oshea_nucleus
2 oshea_nucleus
L[NVQ]N
29 HLVNK
Motif for targeting CD44 to basolateral
Y
membranes
Zn_clus
1.E-04
-1.1
0.006
yeast-649_GO-0003676
PLS[KYH][EKT]
29
RRM_1
1.E-02
-1
0.006
yeast-460_GO-0006351
2 transcription, DNA-dependent
[TDE]G[EAR]KP
29 G[KR][KR]
Amidation after cleavage after Gly (must bezf-C2H2
in secretory pathway)
1.E-08
-1
Y
0.006
yeast-1939_GO-0003824
N[NTQ].[NRS]S
29
Zn_clus
1.E-06
-1
0.006
protein_40_YHL034C
2 SBP1: Putative RNA binding protein; involved in translational
A[AEG]K
repression and found29
in cytoplasmic
WAQKW
P bodies; found
Motifassociated
in Cet1 RNA
with small
triphosphosphatase
nucleolar RNAs snR10
for binding
RRM_1
and snR11
to RNA guanylyltransferase
1.E-02
-1 Ceg1ribonucleoprotein complex (1e-15)
0.005
yeast-335_GO-0016772
DK[YHD]
29 DKTGT[LIVM][TI]
ATPASE_E1_E2 PATTERN
Pkinase
1.E-19
-0.9
protein_40_YNL002C
2 RLP7: Nucleolar protein with similarity to large ribosomalNK[EYL]
29 NKLY
of 66S pre-ribosomalLIM3
particles;
domain
playsinan
enigma
essential
binds
role in
toprocessing
this site inofRet
precursors
Brix
to the large
1.E-02
ribosomal subunit
-0.8 RNAs
0.005
oshea_bud_neck
2 oshea_bud_neck
[QEC]LE[ENL]
29 L..[LM]E
Sec24pSec24pSec24p
RhoGAP
1.E-02
-0.8
Y
0.006
yeast-256_GO-0016462
[PGS]..VL
29
Helicase_C
1.E-12
-0.7
0.006
protein_40_YOL004W
2 SIN3: Component of the Sin3p-Rpd3p histone deacetylase
E[ICA]..D[FAW]
29
repression and activation of diverse processes, including mating-type
SWIRM
switching and 1.E-02
meiosis; involved
-0.7
in the maintenance of chromosomal integrity
Y
0.004
protein_40_YGL105W
2 ARC1: Protein that binds tRNA and methionyl- and K[VTA]..E[AHG]
29 and
[ST]..E
Gus1p), deliveringCasien
tRNA tokinase
them, stimulating
II consensus
catalysis,
phosphorylation
Yand ensuringPkinase
their
site localization to1.E-05
the cytoplasm;-0.7
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-05)
Y
0.006
yeast-216_GO-0006325
2 establishment and/or maintenance of chromatin architecture
P[ADQ]..[RKP]L
29
-0.6
yeast-216_GO-0006323
2 DNA packaging
P[ADQ]..[RKP]L
29
-0.6
protein_40_YOR181W
[ATM]A..I[SDE]
SH3_1 of the human
1.E-02
Wiskott-Aldrich
-0.6syndrome
actin
protein
cytoskeleton
(WASP)
(1e-04)
0.006
protein_40_YLL039C
2 UBI4: Ubiquitin, becomes conjugated to proteins, marking
D.[PID]N
29 D.D
via the ubiquitin-26SRibose
proteasome
moiety
system;
of UDP
essential
and manganese
for the cellularbinding
stress
F-box
response;
site in glucuronyl
encoded
1.E-03
astransferase
a polyubiquitin
-0.6 precursor
ubiquitin
comprised
cycleof(1e-10)
5 head-to-tail repeats
0.005
protein_40_YHR088W
2 RPF1: Nucleolar protein involved in the assembly of theK..K[ERV]
large ribosomal subunit; constituent
29 KRof 66S pre-ribosomal
CLV_PCSK_PC1ET2_1
particles; contains a sigma(70)-like motif, which
IBN_N
is thought to bind1.E-02
RNA
-0.6
Y
0.005
protein_40_YIL094C
V[VLI][QTV]V
-0.5
Y
0.006
protein_40_YDR225W
K[TPV].[TVQ]S
29 required for chromatin assembly and chromosome function; DNA damage-dependent
1.E-05 by Mec1p
-0.5 facilitates
nuclear
DNAnucleosome
repair; acetylated
(1e-04)
by Nat4p
0.006
protein_40_YDR225W
R[AQE]V
29 required
[RK].V.F
for chromatinPPI
assembly
binding
andsites
chromosome function; DNA damage-dependent
1.E-04 by Mec1p
-0.5 facilitates
nuclear
DNAchromatin
repair; acetylated
(1e-06)
by Nat4p
0.006
yeast-468_GO-0051276
N.[NTE]N
29 N.[TS]
Bromodomain
1.E-05
-0.4
0.006
yeast-457_GO-0007001
2 chromosome organization and biogenesis (sensu Eukaryota)
N.[NTE]N
29 N.[TS]
Bromodomain
1.E-05
-0.4
protein_40_YPL217Cs
DE[EIY]
2940S ribosomal
SEDEEsubunits and
CKII
for kinase
processing
phosphorylation
of the 35S pre-rRNA
site (peptide
at sites A0,
screen)
WD40
1.E-03
with Rcl1p, has
-0.4
similarity
rRNA
to Tsr1p
processing (1e-30)
0.005
protein_40_YJR059W
2 PTK2: Putative serine/threonine protein kinase involved in regulation
PK
of ion transport
29across
K...VPK...V
plasma membrane;
Endothelin
enhances receptor
spermine uptake
motif required for endothelin
Pkinase
stimulation 1.E-02
-0.4
0.006
yeast-207_GO-0006974
I..E[TFR]
29
BRCT
1.E-05
-0.2
0.006
protein_40_YDR060W
2 MAK21: Constituent of 66S pre-ribosomal particles, required
A.E[EKL]
29 subunit
FGFRinkinase
nuclear substrate
export of pre-ribosomes;
motif Y required
Helicase_C
-0.2 of cytoplasm
human CAATT-binding
organization
0.005
protein_40_YOL139C
2 CDC33: Cytoplasmic mRNA cap binding protein; the[VEN]Q[NQM]I
29 for mediating cap-dependent mRNA translation via interactions
Y with thePkinase
-0.1 orprotein
0.005
protein_40_YER165W
K.[EGV]K
complex, mediates
29 interactions
[VILMAFP]K.E
between theMOD_SUMOMOD_SUMO
5' cap structure and the 3' mRNA poly(A) tail, involved
RRM_1
1.E-02
tail length,-0.1
interactsRNA
with translation
metabolism
factor (1e-14)
eIF-4G
0.006
protein_40_YJL095W
2 BCK1: Mitogen-activated protein (MAP) kinase kinase kinase
D..[EVC]D
acting in the protein 29
kinase C..D..C
C signaling pathway,40Fe/4-S
which controls
cluster
cell binding
integrity;motif
upon activation by Pkc1p
Pkinase
phosphorylates1.E-02
downstream kinases
0 Mkk1p and Mkk2p
0.005
yeast-661_GO-0050789
I..[LPV]K
29
Zn_clus
1.E-06
0.1
Y
0.006
protein_40_YLR180W
2 SAM1: S-adenosylmethionine synthetase, catalyzes transfer
P.[FDQ]V
of ATPMC[LIV][GA][LIV]P.[QKR][LIV]
HUPF_HYPC
methionine; one
PATTERN
of two differentially regulated isozymes
Sam2p)
0.1
amine metabolism (0.01)
0.006
protein_40_YJL010C
2 NOP9: Essential component of pre-40S ribosomes that is
GR[LDY]
required for early cleavages
29 of 35S
[AG]R
pre-rRNA and hence
Protease
formation
matriptase
of 18S rRNA;
protease
bindssite
RNA in vitro and
WD40
0.1
nucleolus (1e-26)
0.006
yeast-470_GO-0006259
2 DNA metabolism
Q.[QPE]I
29
Y
BRCT
1.E-03
0.2
0.006
yeast-468_GO-0051276
P[PRY]K
29 SPRK
CDK2 kinase phosphorylation site (peptide
Bromodomain
screen)
1.E-02
0.2
Y
0.006
yeast-215_GO-0005694
2 chromosome
E.[DQH]S
SMC_N
1.E-05
0.2
chromosome (1e-12)
0.006
protein_40_YKR001C
E[RN].A[TMP]
29
organization, late Golgi-retention of some proteins, regulating
Y
peroxisome
Actin biogenesis1.E-02
0.2
0.004
protein_40_YJL081C
R[DHP].K[KRI]
KR
enzyme
CLV_PCSK_PC1ET2_1
complexes
Histone
1.E-03
0.2
protein_40_YDR388W
2 RVS167: Actin-associated protein, subunit of a complexS.N[VTK]
HEATor osmotic stress;
1.E-02
homolog of0.2
mammalian
cellamphiphysin
cortex (0.01)
Y
0.005
protein_40_YDR324C
2 UTP4: Nucleolar protein, component of the small subunitD..A[LVC]
Y
WD40
1.E-03
0.3
0.005
yeast-752_GO-0016787
[VDC]L[KVA]R
29 [KR]R
CLV_PCSK_KEX2_1
Helicase_C
1.E-04
0.4
Y
0.006
protein_40_YDL148C
2 NOP14: Nucleolar protein, forms a complex with Noc4pA.G[KNV]
29 nuclear
RALAHGVRVL
Mitochondrial
subunits;
targetting
also present
motif
in in
thehepititis
small subunit
C core
processome
S4protein complex,
1.E-02
which is required
0.4 for small
processing
nucleolar
of pre-18S
ribonucleoprotein
rRNA
complex (1e-27)
0.005
protein_40_YPL217Cs
I..[LKS]A
2940S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, WD40
1.E-05
with Rcl1p, has
0.5
similarity
small
to Tsr1p
0.005
yeast-513_GO-0005515
2 protein binding
NT[LEI]
29 TEY
MEK phosphorylation of MAPK activation sites
F-box
- stringent 1.E-03
0.6
0.006
yeast-424_GO-0006950
2 response to stress
D.[FGN]N
29 F.D.F
LIG_AP2alpha_1
BRCT
1.E-02
0.8
0.006
yeast-217_GO-0007046
L[LGC]..[TGQ]D
29
WD40
1.E-05
0.8
0.006
protein_40_YMR047C
2 NUP116: Subunit of the nuclear pore complex (NPC) thatQ[SQT]K
of the GQDQTKQQI
43_KD_POSTSYNAPTIC
PATTERN
with Y
mRNA exportIBN_N
with karyopherin
0.8
transport (1e-19)
0.005
yeast-752_GO-0016787
E..A
29 [ED].D[ST]EG.A[LI]
Motif in sodium channel that binds ankIryn G Ras
1.E-09
0.9
0.006
protein_40_YLR222C
I[TRY]S[LKV]
29 IY
the U3 snoRNA thatcFGR
is involved
andinCsk
processing
kinase of
phosphorylation
pre-18S rRNA site (peptide
WD40 screen) 1.E-06
0.9
0.006
protein_40_YMR128W
2 ECM16: Essential DEAH-box ATP-dependent RNA helicase
K.L[ATK]
29 predominantly
LLKIL
nucleolar
AP-2
in distribution,
binding motif
required
in CXCR2
for 18S receptor
rRNA synthesis WD40
1.E-03
1
Y
0.005
yeast-322_GO-0005654
2 nucleoplasm
K[QKS]E
29 [VILMAFP]K.E MOD_SUMOMOD_SUMO
Y
Bromodomain
1.E-04
1.1
nucleoplasm (1e-17)
0.006
yeast-301_GO-0044451
2 nucleoplasm part
K[QKS]E
29 [VILMAFP]K.E MOD_SUMOMOD_SUMO
Y
Bromodomain
1.E-04
1.1
0.006
10
8
10
10
10
10
10
9
10
10
9
10
10
10
10
8
10
10
10
10
10
9
10
9
8
10
10
9
10
10
10
10
10
7
8
9
10
10
10
9
10
10
10
10
10
10
10
8
10
10
10
8
10
10
9
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
9
9
9
9
9
10
10
9
10
9
8
10
10
10
10
9
8
9
9
10
9
10
10
8
10
10
10
10
10
10
10
9
10
9
9
9
10
9
10
8
10
10
10
10
9
9
10
10
9
10
10
10
10
8
9
10
10
9
9
9
10
10
9
10
yeast-235_GO-0009653
yeast-235_GO-0000902
protein_40_YGL120C
protein_40_YPL235W
protein_40_YKR048C
yeast-235_GO-0009653
yeast-216_GO-0006325
yeast-216_GO-0006323
protein_40_YDR224C
protein_40_YDL153C
yeast-235_GO-0000902
yeast-1340_GO-0044267
protein_40_YMR229C
protein_40_YDR225W
protein_40_YBR106W
protein_40_YML010W
yeast-205_GO-0005856
yeast-921_GO-0006810
protein_40_YFR010W
protein_40_YNL272C
yeast-631_GO-0050794
protein_40_YLL008W
protein_40_YLR429W
protein_40_YGR128C
protein_40_YDR449C
yeast-593_GO-0031981
protein_40_YLL008W
protein_40_YGL111W
protein_40_YAR019C
protein_40_YNL186W
protein_40_YNL175C
yeast-593_GO-0031981
protein_40_YMR290C
matsuyama_periphery
yeast-548_GO-0051641
protein_40_YGL245W
yeast-544_GO-0016070
protein_40_YKL172W
yeast-1464_GO-0019538
protein_40_YMR049C
yeast-661_GO-0050789
yeast-939_GO-0051234
yeast-792_GO-0006412
yeast-661_GO-0050789
yeast-649_GO-0003676
yeast-521_GO-0051649
yeast-513_GO-0005515
yeast-512_GO-0046907
yeast-470_GO-0006259
yeast-468_GO-0051276
yeast-468_GO-0051276
yeast-437_GO-0044429
yeast-410_GO-0007049
yeast-379_GO-0031975
yeast-379_GO-0031967
yeast-371_GO-0009056
yeast-336_GO-0005783
yeast-320_GO-0006355
yeast-284_GO-0005740
yeast-274_GO-0005840
yeast-262_GO-0031224
yeast-262_GO-0031224
yeast-255_GO-0042254
yeast-255_GO-0007028
yeast-251_GO-0005886
yeast-251_GO-0005886
yeast-248_GO-0043285
yeast-248_GO-0031966
yeast-238_GO-0017111
yeast-222_GO-0009308
yeast-222_GO-0009308
yeast-219_GO-0046903
yeast-215_GO-0007010
yeast-215_GO-0007010
yeast-215_GO-0007010
yeast-203_GO-0005975
yeast-1547_GO-0043283
protein_40_YPR120C
protein_40_YPR120C
protein_40_YPR119W
protein_40_YPR034W
protein_40_YPR034W
protein_40_YPL240C
protein_40_YPL240C
protein_40_YPL240C
protein_40_YPL204W
protein_40_YPL153C
protein_40_YPL151C
protein_40_YPL043W
protein_40_YPL043W
protein_40_YPL012W
protein_40_YOR326W
protein_40_YOR310C
protein_40_YOR272W
protein_40_YOR206W
protein_40_YOR174W
protein_40_YOR133W
protein_40_YOR133W
protein_40_YOL139C
protein_40_YOL133W
protein_40_YOL086C
protein_40_YOL086C
protein_40_YOL069W
protein_40_YOL069W
protein_40_YOL013C
protein_40_YNL308C
protein_40_YNL307C
protein_40_YNL307C
protein_40_YNL307C
protein_40_YNL289W
protein_40_YNL154C
protein_40_YNL154C
protein_40_YNL132W
protein_40_YNL118C
protein_40_YNL118C
protein_40_YNL055C
protein_40_YNL031C
protein_40_YMR304W
protein_40_YMR290C
protein_40_YMR288W
protein_40_YMR236W
protein_40_YMR229C
protein_40_YMR142C
protein_40_YMR047C
protein_40_YMR012W
protein_40_YMR001C
protein_40_YMR001C
protein_40_YML069W
protein_40_YLR448W
protein_40_YLR372W
protein_40_YLR222C
protein_40_YLR186W
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
0.006
0.006
nucleolus (1e-10)
0.006
remodeling complex (1e-05)
0.006
[PVA]R..Q[LTK]
microtubule
[AG]R
dynamics during
Protease
mitosis; matriptase
controls bud protease
morphogenesis;
site involved Histone
1.E-10
and H2B histones
1.4 to the
nuclear
nucleus;chromatin
phosphorylated
(1e-07)
by CK2
0.006
morphogenesis
[TPM]A[GSN]Q
29 [ST]Q
Ras
1.E-06
1.5
0.007
[VKI]LEY[LGC]
29 Y[VLTFIC]
LIG_SH2_STAT5
Histone
1.E-04
1.5
DNA packaging
[VKI]LEY[LGC]
29 Y[VLTFIC]
LIG_SH2_STAT5
Histone
1.E-04
1.5
HTB1: One of two nearly identical (see HTB2) histone[LD]Q[LTE]A
29
1.E-02
transcriptional
1.5 activation,
nuclear
meiotic
chromatin
DSB formation
(1e-04)
and H3 methylation
Y
0.005
TRWYR
Pkinase
disrupts silencing
1.E-02
1.5
Y
0.003
[TPM]A[GSN]Q
29 [ST]Q
Ras
1.E-06
1.6
0.007
[GLK]P..TP[YLC]
29 [ST]P
LIG_WW_4LIG_WW_4
UQ_con
1.E-11
1.6
ubiquitin conjugating enzyme activity (1e-11)
0.006
RRP5: Protein required for the synthesis of both 18S and 5.8S
R..A
rRNA; C-terminal region
29 isR..[PA]DG
LIG_TNKBMLIG_TNKBM
of 18S rRNA and N-terminal region
Y is required
Pkinase
component of small
1.7 ribosomal
nucleolus
subunit(1e-39)
(SSU) processosome
Y
0.005
D.[GF]L
29 required
F.D.Ffor chromatinLIG_AP2alpha_1
assembly and chromosome function; DNA damage-dependent
IBN_N
phosphorylation
1.E-02 by Mec1p
1.7 facilitates
protein
DNAcarrier
repair; acetylated
activity (1e-04)
by Nat4p
0.005
M[NFV].[YVM]L
29double null mutant exhibits enhanced synthesis of repressibleYacid phosphatase
DUP
at high inorganic
1.E-04
1.8
Y
0.005
Q..[NEG]V
29
pre-mRNA processing
1.E-03
2
Y
0.005
cytoskeleton
SS[REF]S[HID]
29 S[ST]
Kinesin
1.E-07
2.1
0.006
transport
L[YFG]V
29 LLG
MFS_1
1.E-04
2.2
0.006
I[HLT]..[LNR]K
29
Pkinase
1.E-03
2.3
spindle (1e-43)
0.007
UBP6: Ubiquitin-specific protease situated in the base
[RDW]D.K[PEQ]
subcomplex of the 26S proteasome,
29
releases free ubiquitin from branched polyubiquitin chains; deletion Pkinase
causes hypersensitivity
1.E-03
to cycloheximide
2.4 and protein
other toxickinase
compounds
activity (1e-04)
Y
0.006
SEC2: Guanyl-nucleotide exchange factor for the small G-protein
M.Y[CM]
Sec4p, located on
29cytoplasmic
YM vesicles; essential
SH2 ligand
for post-Golgi
for Vav1
vesicle
(group
transport
II) (phospho-peptide)
Pkinase
1.E-07
2.6
Y
0.003
RA[AKN][QPT]
29
bZIP_1
1.E-04
2.7
0.006
VA[IAF][KRM]
including
DVAD
Proteasesubunits;
Caspase
constituent
2 -stringent
Pkinase
particles
1.E-07
2.9
0.006
AP[EKN]
29 APAP
complex to regulate
Motif
its activity;
for hydroxylation
plays a role in
ofregulation
Pro residues,
of actinwhich
patch
Pkinase
can
assembly
further be modified
1.E-04 with arabinogalactan
3
0.005
UTP8: Nucleolar protein required for export of tRNAs from
D..[EVD]K
the nucleus; also copurifies
1.E-06
of pre-18S 3
Y
0.005
[AYV]T..[YMR]D
29 the
T..RDP.[FY][FYW]
U3 snoRNA that isHEMOCYANIN_2
PATTERN
of pre-18S rRNA
WD40
1.E-03
3
Y
0.004
nuclear lumen
TP..[VLH][LMF]D
29 [ST]P
LIG_WW_4LIG_WW_4
DEAD
1.E-06
3.2
0.006
D.K[PKE]
Pkinase
particles
1.E-11
3.3
0.005
[REQ][EQW]LA
29biogenesis
[KRHQSA][DENQ]EL
ER_TARGET PATTERN
Y
DEAD
1.E-03
3.3
Y
0.006
CDC15: Protein kinase of the Mitotic Exit Network that isY[LMH]H
1.E-19
3.3
Y
0.006
UBP10: Ubiquitin-specific protease that deubiquitinates ubiquitin-protein
[IFV].HR
moieties; 29
Y
regulating
Pkinase
Gap1p and 1.E-22
3.5
protein
primarily
kinase
locatedactivity
in the nucleus
(1e-19)
Y
0.006
NOP13: Protein of unknown function, localizes to the [LM]L.SA[TI]
contains an RNA recognition motif (RRM) and has similarity to Nop12p,
Y
which DEAD
1.E-06of pre-18S
3.5rRNA RNA helicase activity (1e-05)
0.004
nuclear lumen
TD.[SAP][KFA]R
29 [KR]R
CLV_PCSK_KEX2_1
Helicase_C
1.E-03
3.6
0.006
R[ECF][LQT]A
29
highly enriched in nuclear pore complex fractions; constituent of 66SDEAD
1.E-03
3.6
0.006
matsuyama_periphery
G..[HLY]R
29 FQ...RG...R..[FY]
Myosin light chain binding motifs Type IA - Ca
Pkinase
independent Smooth
1.E-07muscle3.9
cell septum (1e-46)
Y
0.007
KL[IVF]T
29
IBN_N
1.E-02
4
0.006
GUS1: Glutamyl-tRNA synthetase (GluRS), forms a [MRA]AP[ETR]
synthetase
P[TS]AP
(Mes1p) and Arc1p;
LIG_PTAPLIG_PTAP
complex formation increases the catalytic efficiency
Pkinase
of both tRNA1.E-12
synthetases and
4.3
ensuresprotein
their correct
kinase
localization
activity
to the
(1e-13)
cytoplasm
Y
0.005
RNA metabolism
DEA[DNP][RKQ]
29 [LIVMF][LIVMF]DEAD[RKEN].[LIVMFYGSTN]
DEAD_ATP_HELICASE PATTERN
DEAD
1.E-13
4.5
0.006
EBP2: Essential protein required for the maturation of
V[GKS]R[TRL]
25S rRNA and 60S ribosomal
29subunit
[KR]R
assembly, localizes
CLV_PCSK_KEX2_1
to the nucleolus; constituent of 66S
Ypre-ribosomal
Helicase_C
particles
1.E-02
4.5
0.006
protein metabolism
[HDG]R..[KQ]P
29 R..K
Y recognizing
Pkinase
1.E-28
5.4
0.006
[HGE]R.G[RCQ]
29 ofRGG
66S pre-ribosomalAlternative
integrin binding
to mammalian
site inBop1
FMDV virus
Helicase_C
1.E-04
6
0.006
R.[HNT]T
29 R.[ST]
zf-C2H2
1.E-07
6.7
Y
0.006
[LKQ]V..[ED]N
29
0.006
S.D[GNM]
29 S.D
0.006
[FTC]T..[TND]K
29 T..D
FHA1 binding motif, Thr must be phosphorylated, binding motif of proteins binding to
regulation
Chk2
of metabolism (1e-27)
Y
0.006
G[QPV][KHQ]R
29 [KR]R
CLV_PCSK_KEX2_1
0.006
establishment of cellular localization
E[SIV]..[DTM]A
29
Y
0.006
protein binding
GS..[PQW][FQM]
29
Y
0.006
intracellular transport
[IMW]EL[LEC]
29
0.006
DNA metabolism
R[QKA]Q
29 KRKQISVR
Phosphorylase kinase substrateYmotif
Y
0.006
L[LKT]..[QHM]Q
29
Q[KNQ]L[LEQ]
29
0.006
mitochondrial part
I..[KTP]S
29
0.006
cell cycle
LI..[EFD][SEA]L
29
cell cycle (1e-19)
0.007
envelope
E.E[LDC]
29 Y.E.E
0.006
organelle envelope
E.E[LDC]
29 Y.E.E
0.006
catabolism
[AQT]G..[TEA]A
29
catabolism (1e-50)
0.006
VA[LIF]
29
0.006
[DNH]G.[EMV]K
29
0.006
F.I[LRN]
29
0.006
ribosome
[EKV][AVE]AKK
29
ribosome (1e-22)
0.007
F[GEQ].S[AM]
29
0.007
V.A[VYF]
29
Y
0.006
R..A[RQL]
29
Y
0.006
R..A[RQL]
29
Y
0.006
plasma membrane
[SYW]T..V[TYI]
29
Y
0.006
plasma membrane
Y[GYN]G
29 GGQ
N-methylation motif in E. coli, Gln residue in methylated, mimics CCA motif at the end
plasma
of tRNA
membrane
molecule (1e-73)
0.006
biopolymer catabolism
AL.[AG][YTW]S
29
biopolymer catabolism (1e-07)
0.004
mitochondrial membrane
K.[KTI]K
0.006
I.G[PNR]
29 GP
Y
0.006
amine metabolism
A[LKF]..[MCY]G
29
0.007
amine metabolism
A[VRL]..[EYD]T
29
0.006
secretion
[ESC]N.IK[SLD]
29
Y
0.005
[LVC]E..Q[AM]
29
Y
0.007
[PNL]T[NEL]I
29 PTL
0.006
S..[IRM]N
29
Y
0.006
D..[NVL]S
29
0.006
Y[IVT]..Y[LDQ]
29 Y[VLTFIC]
LIG_SH2_STAT5
DNA metabolism (0.001)
0.006
CLB5: B-type cyclin involved in DNA replication during SL.[SRP]P
to promote
[ST]P
initiation of DNALIG_WW_4LIG_WW_4
synthesis; functions in formation of mitotic
Y
spindles along with Clb3p and Clb4p; most abundant during late G1 phase
Y
0.005
CLB5: B-type cyclin involved in DNA replication during SR.L[KSC]
to promote
R.L initiation of DNACyclin
synthesis;
A motif
functions
that binds
in formation
cdk2 of
complexes
mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
Y
0.005
[YMH]G..N[NDS]
29the transition from G2 to M phase; accumulates during G2 andYM, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
Y
0.006
[QGC]N.L[IPV]
0.005
[RF]TF[TDR]
SWI/SNF complex (0.01)
0.004
F[NIL]S[SDK]
29of Hsf1p;
S[ST]
docks with Tom70p
MDC1
for BRCT
mitochondrial
domain
preprotein
bindingdelivery;
motif promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
Y
0.005
HSP82: Hsp90 chaperone required for pheromoneLL.D[VGQ][VFQ]
29of Hsf1p;
LLGdocks with Tom70p
Beta2-Integrin
for mitochondrial
binding
preprotein
motif delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
0.005
T...Y
0.006
HRR25: Protein kinase involved in regulating diverse events
K.G[KMR]
including vesicular trafficking,
29
DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta
ribosome
(CK1delta)
biogenesis (0.01)
0.005
RAD53: Protein kinase, required for cell-cycle arrest[DAE]K..I[TNK]
Y
0.006
PRP46: Splicing factor that is found in the Cef1p subcomplex
TE[VY][LGR]
of the spliceosome 29
TEY
MEK phosphorylation of MAPK activation sites - stringent
0.005
[FGA]R.I[SPM]
and large
[AG]R
ribosomal subunit
Protease
biogenesis;
matriptase
constituent
protease
site
particles; contains four RNA recognition motifs (RRMs)
0.005
NOP4: Nucleolar protein, essential for processing and maturation
D.E[EHI]
of 27S pre-rRNA29
and large
SD.E
ribosomal subunit
Casein
biogenesis;
kinase
constituent
II substrate
of 66S
motif
pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
nucleolus (1e-28)
0.006
RRP12: Protein required for export of the ribosomal subunits;
R..[KRD]T
associates with the RNA
29 components
R..K
of the pre-ribosomes;
SH3 binding
contains
motif for
HEAT-repeats
GADS SH3 recognizing slp-76 motif (nonconventional)
nucleolus (1e-24)
Y
0.005
MYO2: One of two type V myosin motors (along withL[AMH][TGD]V
0.005
R[AVS]Q[LKF]
29synthesis;
[ST]Qcomponent of ATM
the small
kinase
subunit
phosphorylation
processome complex,
site which is required for processing of pre-18S rRNA
0.006
VG..[EIG][NTH]
0.005
E[AED].V[PKS]
66S pre-ribosomes,
EEEYV as wellPDGF
as a nuclear
receptor
complex
kinase
withphosphorylation
Noc3p that
Y binds tosite
66S
(peptide
pre-ribosomes;
screen)both complexes mediate intranuclear
nucleolus
transport
(1e-13)
of ribosomal precursors
Y
0.006
NG[SNI][SNA]
29
0.006
T[VSD].V[ELF]
29
during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
0.006
TV[AGE]
29 YTV
14-3-3 contains
domaindiphthamide,
binding motif
the unique posttranslationally modified histidine residue specifically
translation
ADP-ribosylated
elongation
by diphtheria
factor
toxin
activity (0.001)
0.005
CDC33: Cytoplasmic mRNA cap binding protein; theT[VQK]..I[LAH]
29 for mediating cap-dependent mRNA translation via interactions
Y with the translation initiation factor eIF4G (Tif4631p or Tif4632p)
0.006
[DEG]E.F[STD]
29(SCF);
EEEYF
required for Gic2p,EGFR
Far1p,kinase
Sic1p and
phosphorylation
Cln2p degradation;
sitemay
(peptide
tether screen)
Cdc34p (a ubiquitin conjugating enzyme or E2)
catabolism
and Cdc53p(0.001)
(a cullin) subunits of SCF
Y
0.006
K[QVH].N[VWT]
29
Y
0.004
P[ETF][VRD]K
29 P[ST]
DNA dependent
of acetaldehyde
Protein
to ethanol,
kinasethe
substrate
Ylast step motif
in the glycolytic pathway
0.005
[VKP]DS[TEG] Ndc80 complex
29 [DE]S[DE].[DE]
Casein Kinaseinvolved
II substrate
in chromosome
motif
segregation, spindle checkpoint activity and kinetochore clustering
0.005
RR..[EST][ETG] Ndc80 complex
29 R..[ST]
CamKII consensus
involved
phosphorylation
in chromosome segregation,
site
spindle checkpoint activity and kinetochore
microtubule
clustering
cytoskeleton (0.001)
0.006
A[NDR].I[ADF]
29
(ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger
0.005
A.R[IDP]
and functionally interacts with Krr1p
Y
0.006
MCK1: Protein serine/threonine/tyrosine (dual-specificity) kinase
E..V involved in control29of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family
0.005
MCK1: Protein serine/threonine/tyrosine (dual-specificity)P.[IAS]A
29of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family
0.005
S.E[ESY]
29of chromosome
LSQE segregation
ATM
andkinase
in regulating
substrate
entry motif
into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family
Y
0.006
S..T[SNP]
29cycleS..[ST]
Casein Kinase
localizes
I consensus
to sites phosphorylation
of polarized cell growth
site (N-term Ser must first be phosphorylated)
0.006
YCK2: Palmitoylated, plasma membrane-bound casein
GL..[DTV][RDE]
29
functions with Yck1p in morphogenesis, proper septin assembly,
Y
endocytic trafficking; provides an essential function
cytokinesis
overlapping (0.01)
with that of Yck1p
0.005
YCK2: Palmitoylated, plasma membrane-bound casein
Q[DIG]..P[SIY]
29 P[ST]
DNA
in morphogenesis,
dependent Protein
properkinase
septin assembly,
substrateendocytic
motif trafficking; provides an essential function overlapping with that of Yck1p
Y
0.006
V[RQF]V
29 RALAHGVRVL
in K1 killer toxinMitochondrial
resistance
targetting motif in hepititis C core protein
0.005
K[SAW].[TDA]F
29
Y
0.005
R[AKW]..L[LK]
29
Y
0.006
POR1: Mitochondrial porin (voltage-dependent anionRV[GHE][GQI]
29 required
VEID for the maintenance
Protease
of mitochondrial
Caspase 6 -stringent
osmotic stability and mitochondrial membrane permeability; phosphorylated
0.004
HHT2: One of two identical histone H3 proteins (seeDE[DTW][GIR]
29 forYDE[PDV]
chromatin assembly,
SH2
involved
ligandin for
heterochromatin-mediated
Nck1 and Nck2 (Tyr must
telomeric
be and
phosphorylated)
HM silencing; regulated by acetylation, methylation,
transcription,
and mitotic
DNA-dependent
phosphorylation(1e-04)
0.006
[LKM]Q[RVQ]E
29
Y
establishment and/or maintenance of cell polarity (sensu Fungi) (0.01)0.005
HAS1: ATP-dependent RNA helicase; localizes to both the nuclear
A.R periphery and nucleolus;
29 [RK].PNS[AR].R
highly enriched inRIBOSOMAL_S12
nuclear pore complexPATTERN
fractions; constituent of 66S pre-ribosomal particles
0.005
HSH155: U2-snRNP associated splicing factor that forms
K..[KQ]V
extensive associations with
29 the K...VPK...V
branch site-3' spliceEndothelin
site-3' exon region
receptor
upon
motif
prespliceosome
required forformation;
endothelin
similarity
stimulation
to the mammalian U2 snRNP-associated
nuclearsplicing
mRNA
factor
splicing,
SAP155via spliceosome (1e-38)
0.006
G[ELA][DYW]D
29 II transcription
[WFY]G[PDE][WFYLM]
initiation and
gamma-adaptin
in chromatin modification,
ear binding
similar
motifto histone H3
Y
0.005
RRP5: Protein required for the synthesis of both 18S[GPH]R[KHR]V
29 is[AG]R
Protease
of 18Smatriptase
rRNA and N-terminal
proteaseregion
site is required for the 5.8S rRNA; component of small ribosomal
nucleolus
subunit(0.001)
(SSU) processosome
0.006
K[IVT]R[AG]
to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
0.004
Q.[KQC]P
of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p;nuclear
homologous
pore
to (1e-19)
Nup100p
Y
0.006
[GTY]V..T[FHM]
0.005
N[KLV][DAN]G
microtubule
be a Cdc28pcytoskeleton
substrate
0.006
V[IKH].K[QAK]
M phase
be a Cdc28p
(1e-04)
substrate
0.005
POB3: Subunit of the heterodimeric FACT complex[DYW]E.E[DAN]
29 RNAYE
Pol II transcription TPK-IIB/P38Syk
elongation through nucleosomes
by destabilizing
site
and
(peptide
then reassembling
screen) nucleosome structure;RNA
interacts
elongation
with DNA polymerase
from RNAalpha
polymerase
(Pol1p)
II promoter (1e-10)
0.006
A[PAG]K[IGR]
29 KR
and to rat L6 ribosomal
CLV_PCSK_PC1ET2_1
Y
0.006
T[LWF]..[AGR]V
very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
0.006
A[RGA].[KPY]A
to Rps30Bp and has similarity to rat S30 ribosomal protein
0.006
L[TKN]G[QG]
29 LFG
the U3 snoRNA thatProtease
is involvedPapain
in processing
substrate,
of pre-18S
a prototype
Y
rRNA cysteine proteinase
Y
0.005
[ADT][FKN].KF
production; associated with spindle/microtubules; nuclear localization depends on physical interaction with Nop14p; may bind
rRNA
snoRNAs
processing (1e-12)
Y
0.005
morphogenesis
T..Q[EQI]
T..Q[EQI]
29
29
Ras
Ras
1.E-03
1.E-03
D[IKA]..V[ETM]
I and polymerase II transcript metabolism, involved in release of the lariat-intronBrix
1.E-03
1.3
1.3
1.3
RVB2: Essential protein involved in transcription regulation;
D.[ERA]V
component of chromatin
29remodeling
SD.E complexes; required
Casein for
kinase
assembly
II substrate
and function
motif
of the INO80 complex;
Actin member of the
1.E-04
RUVB-like protein
1.4 family
chromatin
9
9
10
10
10
10
9
9
10
7
10
10
10
10
10
10
10
9
10
8
9
10
10
10
9
9
8
8
10
10
9
7
9
10
10
10
9
8
10
9
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
9
10
10
10
10
10
9
9
9
10
10
7
10
10
10
10
8
10
10
9
10
10
10
9
10
9
9
10
10
10
8
10
10
8
10
10
9
10
9
10
9
10
10
10
8
7
8
10
10
9
9
10
10
10
10
10
10
9
8
10
9
9
9
10
10
9
10
8
10
8
10
10
10
10
10
10
9
9
protein_40_YLR180W
protein_40_YLR180W
protein_40_YLR166C
protein_40_YLR129W
protein_40_YLR129W
protein_40_YLR106C
protein_40_YLR096W
protein_40_YLR074C
protein_40_YLR074C
protein_40_YLL045C
protein_40_YKR026C
protein_40_YKL203C
protein_40_YKL203C
protein_40_YKL172W
protein_40_YKL104C
protein_40_YKL065C
protein_40_YJR123W
protein_40_YJR059W
protein_40_YJL190C
protein_40_YJL109C
protein_40_YJL095W
protein_40_YJL092W
protein_40_YJL074C
protein_40_YIL144W
protein_40_YIL133C
protein_40_YIL075C
protein_40_YIL061C
protein_40_YIL061C
protein_40_YHR203C
protein_40_YHR197W
protein_40_YHR196W
protein_40_YHR196W
protein_40_YHR082C
protein_40_YHR079C
protein_40_YHR064C
protein_40_YHR030C
protein_40_YHL034C
protein_40_YGR274C
protein_40_YGR218W
protein_40_YGR218W
protein_40_YGR128C
protein_40_YGR090W
protein_40_YGR085C
protein_40_YGR040W
protein_40_YGR040W
protein_40_YGL195W
protein_40_YGL180W
protein_40_YGL179C
protein_40_YGL173C
protein_40_YGL137W
protein_40_YGL120C
protein_40_YGL111W
protein_40_YGL076C
protein_40_YGL076C
protein_40_YFR037C
protein_40_YFR037C
protein_40_YFL037W
protein_40_YFL037W
protein_40_YER133W
protein_40_YER082C
protein_40_YER036C
protein_40_YER018C
protein_40_YER006W
protein_40_YDR510W
protein_40_YDR471W
protein_40_YDR418W
protein_40_YDR414C
protein_40_YDR388W
protein_40_YDR381W
protein_40_YDR381W
protein_40_YDR365C
protein_40_YDR356W
protein_40_YDR324C
protein_40_YDR303C
protein_40_YDR174W
protein_40_YDR145W
protein_40_YDR145W
protein_40_YDR064W
protein_40_YDR060W
protein_40_YDL213C
protein_40_YDL153C
protein_40_YDL097C
protein_40_YDL047W
protein_40_YDL013W
protein_40_YCR086W
protein_40_YCR031C
protein_40_YCL059C
protein_40_YBR247C
protein_40_YBR217W
protein_40_YBR217W
protein_40_YBR191W
protein_40_YBR079C
protein_40_YBR055C
protein_40_YBR048W
protein_40_YBR010W
protein_40_YAL035W
protein_40_YAL032C
protein_40_YAL032C
oshea_spindle_pole
oshea_mitochondrion
oshea_ER
oshea_endosome
oshea_bud
matsuyama_Nucleus
matsuyama_ER
matsuyama_Cytosol
genetic_YPL055C
genetic_YPL055C
genetic_YPL055C
genetic_YNL153C
genetic_YLR262C
genetic_YLR039C
genetic_YLR039C
genetic_YGL058W
genetic_YGL020C
genetic_YEL003W
genetic_YEL003W
genetic_YDL020C
ucsf_loc_k_means_G6
protein_40_YGL105W
protein_40_YDL153C
protein_40_YBR010W
protein_40_YPL004C
protein_40_YMR304W
protein_40_YPR144C
yeast-649_GO-0003676
yeast-648_GO-0050791
yeast-207_GO-0006974
protein_40_YMR093W
protein_40_YIL019W
protein_40_YHR052W
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
6
2
2
2
2
2
2
2
2
2
2
2
2
D.R[DRV]
0.005
9
0.003
8
0.006
10
0.006
9
DIP2: Nucleolar protein, specifically associated withK[QVA]..L[IQG]
29 ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the
rRNA
activeprocessing
pre-rRNA processing
(1e-21)complex
0.006
10
MDN1: Huge dynein-related AAA-type ATPase (midasin),
AG.[NSV][TAW]
particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p), may mediate Y
ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm
0.005
9
KIN2: Serine/threonine protein kinase involved in regulation
[SDR][TDW].SL
of exocytosis; localizes
29to the cytoplasmic face of the plasma membrane; closely related to Kin1p
0.006
10
BUD20: Protein involved in bud-site selection; diploidA[VW][TRV]K
29 pattern instead of the wild-type bipolar pattern
Y
0.005
9
BUD20: Protein involved in bud-site selection; diploid
R[AEN][APQ]R
29 pattern
[AG]Rinstead of theProtease
wild-type bipolar
matriptase
pattern
protease site
Y
ribosomal large subunit biogenesis (0.001)
0.005
9
A..V[AED]
to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
0.005
9
GCN3: Alpha subunit of the translation initiation factor
G[SAH][NKY]V
29 exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of
eukaryotic
GCN4 expression
translation initiation factor 2B complex (0.001)
0.005
10
G[IMA]..[LMD]S
involved in meiosis
Y
0.006
10
TOR2: PIK-related protein kinase and rapamycin target; subunit
I.[LMR]I
of TORC1, a complex
involved in meiosis
Y
0.006
9
EBP2: Essential protein required for the maturation ofEE[ERV][EG]
25S rRNA and 60S ribosomal
29subunit
YEE[IV]
assembly, localizes
SH2
to the
ligand
nucleolus;
groupconstituent
1A, Src FGR
of 66S
SH2
pre-ribosomal
domain (needs
particles
to be Tyr phosphorylated)
Y
0.006
10
D..L[RAQ]
of glucosamine-6-P and glutamate from fructose-6-P and glutamine
Y in the first step of chitin biosynthesis
INO80 complex (0.001)
Y
0.005
8
YET1: Endoplasmic reticulum transmembrane protein;
[GWM]L..L[IPC]
29based[LV][DE].[LM][LM]..L
on co-purification experiments;
LIG_PXLLIG_PXLLIG_PXL
homolog of human BAP31 protein
cation transporter activity (0.01)
0.005
9
AG[KRH][GFC]
subunit, the least basic of the
29 non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal
cytosolic
proteinsribosome (sensu Eukaryota) (1e-04)
0.005
10
PTK2: Putative serine/threonine protein kinase involvedA..[HET]S
29across
[VA]P[IL]A..E[SD]D
plasma membrane;
Ankryn
enhances
G binding
spermine
motif
uptake
in voltage gated sodium channels
0.005
10
K[KRP]A
to Rps22Bp
KR and has similarity
CLV_PCSK_PC1ET2_1
to E. coli S8 and rat S15a ribosomal proteins
cytosolic part (1e-23)
0.005
8
[RFY]VD[IPC]
nucleolus (1e-08)
0.005
9
A[AMI]E[VYL]
kinase AEVD
C signaling pathway,Protease
which controls
Caspase
cell integrity;
10
upon activation
Y
by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.006
9
[SER]I.[VNW]E
for proper timing of commitment to meiotic recombination and transition
Y
from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
0.006
10
SMC3: Subunit of the multiprotein cohesin complex V[DCK].A[LTY]
29
0.005
10
Q[LQE]..[LYA]E Ndc80 complex
29 YE
TPK-IIB/P38Syk
conserved
kinasecoiled-coil
phosphorylation
protein involved
site (peptide
in chromosome
screen)
segregation, spindle checkpoint
microtubule
cytoskeleton
assembly
organization
and clustering
0.006
10
RPL16A: N-terminally acetylated protein component[AHK][GV]..RG
29
binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated
cytoplasm
by Rap1p organization and biogenesis (1e-05)
0.005
9
RPN2: Subunit of the 26S proteasome, substrate ofA[TKQ].[VAM]D
the N-acetyltransferase Nat1p29
0.005
9
SNP1: Component of U1 snRNP required for mRNARL[EMW][KVI]
interact
LEVD
Protease
to regulate
Caspase
polyadenylation;
4-stringent homolog of human U1 70K protein
mRNA metabolism (0.001)
0.006
10
SNP1: Component of U1 snRNP required for mRNA splicing
Y.[RDC]E
via spliceosome; may29
interact
FRY.CEG
REL_1
to PATTERN
regulate polyadenylation; homolog of human U1 70K protein
small nuclear ribonucleoprotein complex (1e-07)
0.005
8
RPS4B: Protein component of the small (40S) ribosomalR..[VA]R
29 and[AG]R
has similarity to rat Protease
S4 ribosomal
matriptase
protein protease site
0.006
9
[VKP]K..[SKA]K
29for processing
K..[ST] of ITS2 sequences
PKA kinase
from substrate
35S pre-rRNA;
motifRix1 complex
Y
associates with Mdn1p in pre-60S ribosomal particles
0.006
8
[QYG]G.K[ILG]
Y
0.006
10
UTP9: Nucleolar protein, component of the small subunitK[LEC]D
29 the
[NT]K.D
U3 snoRNA that isMotif
involved
for binding
in processing
guanine
of pre-18S
nucleotides
rRNA
nucleolus (1e-29)
Y
0.005
10
KSP1: Nonessential putative serine/threonine protein
VT.[NDW][DFS]
kinase of unknown cellular role;
0.005
10
IRE1: Serine-threonine kinase and endoribonuclease; transmembrane
S..R[GHP] protein that29
mediates
R..[ST]..R
CLK1
response
kinase(UPR)
substrate
by regulating
motif Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
Y
0.006
10
SSZ1: Hsp70 protein that interacts with Zuo1p (a DnaJ
D[NAY]..[VR]T
29
complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.005
9
ST[DTM][DIK]
wall integrity
S[ST]and progression
MDC1
through
BRCT
the cell
domain
cycle; binding
regulatedmotif
by the PKC1-mediated signaling pathway
0.006
10
SBP1: Putative RNA binding protein; involved in translational
[RDP][VKE]AA
repression and found29
in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
0.006
10
E[KQP]D[EDF]
29 has IEPD
Protease
activity,
Granzyme
involved inBpromoter binding and G1/S progression
0.006
10
[KAT]V.[AVI]K
29 from the nucleus
Y
0.006
10
Q..[QGV]E
29 from the nucleus
Y
0.005
10
UTP8: Nucleolar protein required for export of tRNAsV[GT].[SR]TR
29 with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
Y
0.003
7
R[PGH]G[RDH]
29on computational
GGRGG analysis
Arginine
of large-scale
methyl
protein-protein
transferease
interaction
substrate
data
motif (PRMT1)
35S primary transcript processing (1e-04)
Y
0.005
10
AA..[ARC][EHA]
to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity
cytosolic
to E. coli
ribosome
L5 and rat
(sensu
L11
Eukaryota) (1e-27)
0.006
8
KSS1: Mitogen-activated protein kinase (MAPK) involvedAN[STR]
29
that control filamentous growth and pheromone response;
Y the KSS1 gene is nonfunctional in S288C strains and functional
cell growth
in W303
(0.01)
strains
Y
0.005
10
K[KGP]..L[SDE]
29
Y
0.005
9
GCN1: Positive regulator of the Gcn2p kinase activity,
G[LVC]..[NKY]V
forms a complex with Gcn20p;
29 proposed to stimulate Gcn2p activation by an uncharged tRNA
0.005
10
ATG1: Protein serine/threonine kinase, required for vesicle formation
D.P
during autophagy
29 and
DLPPP
EVH1 binding
targetingmotif
(Cvt) pathway; structurally required for pre-autophagosome formation; forms a complex with Atg13p and Atg17p
0.005
10
[SRH]DQ[NQR]
0.005
10
[ET]S.[SG]LT
29 (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance
0.003
7
SEC27: Essential beta'-coat protein of the COPI coatomer,
A[EG]A[QFE]
and Golgi-to-ER
CL[LV]A.A[LVF]A
transport;Ccontains
ASEIN_ALPHA_BETA
WD40 domains that
PATTERN
mediate
Y cargo selective interactions; 45% sequence identity to mammalian
double-strand
beta'-COP
break repair via break-induced replication (0.001)
0.005
9
LLE[DKA][DQY]
0.005
8
Q[DEF]K[QPE]
29biogenesis
FKPY
TLA binding motif in Brinker transcription factor for binding TLA domain in Groucho cytoplasm organization and biogenesis (1e-11)
0.005
7
E[DGA]..E[ISA]D
Rpl7Bp
E[ST]D
and has similarity Ankyrin
to E. coli G
L30
binding
and rat motif
L7 ribosomal
in KNCQ2
proteins;
and contains
KNCQ3apotaqssium
conserved C-terminal
channels
Nucleic acid Binding Domain (NDB2)
0.003
7
RPL7A: Protein component of the large (60S) ribosomalR..R[AKC]
Rpl7Bp
R.[RK]R
and has similarity CLV_PCSK_FUR_1
to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding
cytosolic
Domain (NDB2)
0.005
10
RSC8: Component of the RSC chromatin remodeling complex;
E..[KTS]R
essential for viability
29and mitotic
[KR]Rgrowth; homolog
CLV_PCSK_KEX2_1
of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.005
10
K[RPM]..G[LNQ]
29and mitotic
KR growth; homolog
CLV_PCSK_PC1ET2_1
of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
RSC complex (1e-04)
0.005
9
[IQM]N..[IQT]Q
29dimer,
[ST]Q
which polymerizesATM
to form
kinase
microtubules
0.005
10
[RQA][ACG]..NK
29dimer,
G[SA]LNK
which polymerizesGDP-mannose
binding motif in transporter
Y
Y
0.004
8
[TAW]A..[NRD]A
29manyLK[EAD]AE.RA[ET]
processes includingTROPOMYOSIN
glycogen metabolism,
PATTERN
sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
Y
0.006
10
[SQL]D[DI]E
29 the
S[LW]LD[DE]EL[LM]
U3 snoRNA that isTRG_LysEnd_GGAAcLL_2
Y
0.006
10
E[KPF]K[ER]
ribosome
KRbiogenesis, has similarity
CLV_PCSK_PC1ET2_1
to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p translation (0.001)
0.006
10
SPC25: Component of the evolutionarily conserved D[DNF].H[SNQ]
microtubule
clustering associated complex (0.001)
0.005
10
R..V[KPR]
required for export
0.005
10
T[TKE]T
29 proteins;
AGYGST.T
regulates chromatid
ICE_NUCLEATION
PATTERN
segregation,
Y
APC-mediated proteolysis, DNA replication and septin ring dynamics
Y
0.005
10
A[RG]K[AGV]
0.006
10
RPL12B: Protein component of the large (60S) ribosomalL..I[LTF]
to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
0.005
10
ERD1: Predicted membrane protein required for the retention
II.[TYL][ICT]
0.006
9
M[IPY]D
involved
29 in regulation
DMQD of actin cytoskeleton,
Protease Caspase
endocytosis,
3 -stringent
and viability following starvation or osmotic stress; homolog of mammalian amphiphysin
0.005
10
DI..[NVL][FRS]
29 mRNA from the nucleus; member of the REF (RNA and export
Y factor binding proteins) family; another family member,nuclear
Yra2p, can
lumen
substitute
(0.001)
for Yra1p function
Y
0.005
9
PS.[YKE][ALK]
29 mRNA
P[ST]from the nucleus;
DNAmember
dependent
of the Protein
REF (RNA
kinase
and export
substrate
factor motif
binding proteins) family; another family member, Yra2p, can substitute for Yra1p function
0.005
9
[DTP]K.[GTN]R
29decreased
[AG]R18S rRNA levels
nucleolus (1e-05)
0.006
10
L[KEW].[ATM]N
29 involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated byspindle
Mps1p inpole
body (1e-17)manner
0.006
9
UTP4: Nucleolar protein, component of the small subunitI..[APT]R
29 the
[AG]R
U3 snoRNA that isProtease
involved in
matriptase
processing protease
of pre-18Ssite
rRNA
Y
nucleolus (1e-24)
Y
0.006
10
RSC3: Component of the RSC chromatin remodelingIN..[IFV][VYC]
RSCtocomplex
Rsc30p (1e-07)
Y
0.004
7
HMO1: Chromatin associated high mobility group (HMG)E.[KIC]E
29genome
EEEIYEEIE
maintenance; rDNA-binding
cFPS/FEScomponent
of the Pol I transcription
site
system; associates with a 5'-3' DNA helicase and
nuclear
Fpr1p, alumen
prolyl isomerase
(0.001)
0.005
9
[QDS]AD[ESC]
29 DVAD
Protease
and in chromatin
Caspasemodification,
2 -stringentsimilar to histone H2A
0.006
10
N.T[NAQ]
29 N.[TS]
N-linked
and inglycosylation
site
similar to histone H2A
0.006
9
RPS13: Protein component of the small (40S) ribosomalSS[SFY]
29coli S15
S[ST]
MDC1proteins
BRCT domain binding motif
0.005
10
[VRT]VR[AVG]
29 subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of cytosolic
human CAATT-binding
ribosomeprotein
0.006
10
QK.[KRL][ICH]
29RNAWAQKW
Motifand
in Cet1
has similarity
RNA triphosphosphatase
to hydrophilins; NOP6for
may
binding
be a fungal-specific
to RNA guanylyltransferase
gene as no homologs
Ceg1
have
nucleolus
been yet identified
0.006
9
M[SR]..SSL
29for pre-18S
RSSLHL
rRNa processing;
Motifessential
in beta-arrestin
nucleolar protein
2 for interaction
that, when overproduced,
with Jnk3 disrupts silencing
0.004
8
[LYC][LYA]DK
26S proteasome lid required
29for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletionproteasome regulatory particle (sensu Eukaryota) (0.001)
0.006
10
SIT4: Type 2A-related serine-threonine phosphataseH[LPR]N[SNV]
29 of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and
phosphotransferase
activity, alcohol group as acceptor (0.01)
0.004
8
[NYK]Q..Q[QDN]
0.005
9
CSM1: Nucleolar protein that forms a complex with F[DKM].N[SEQ]
29
during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
0.005
7
RPS14A: Ribosomal protein 59 of the small subunit,[KRH]RA[RAQ]
29and [KR]R
CLV_PCSK_KEX2_1
mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E.cytosolic
rat S14 ribosomal
(sensuproteins
Eukaryota) (1e-15)
0.006
10
[VTA]E..E[EPD]
nucleolus (1e-14)
0.006
10
ENP1: Protein associated with U3 and U14 snoRNAs,
[KCA]ED[DER]
29 and
EDAIY
Abl kinase
synthesis;
substrate
localized
motif
in the nucleus and concentrated in the nucleolus
nucleolus (1e-15)
0.006
10
ATG12: Ubiquitin-like modifier, conjugated via an isopeptide
G.[TQE]A
29of Atg5p by the E1 enzyme, Atg7p, and the E2 enzyme, Atg10p, a step that is essential for autophagy
0.006
10
ATG12: Ubiquitin-like modifier, conjugated via an isopeptide
K[VAF]I
29of Atg5p
D.G.T..K.I
by the E1 enzyme,
Pyrophosphate
Atg7p, and thebinding
E2 enzyme,
motif,
Atg10p,
active
Y a step
site for
thatS-Adenosylmethionine
is essential for autophagy (AdoMet) synthetase
amine metabolism (0.01)
0.005
9
[ALT][RGH].KA
0.005
9
RPG1: Subunit of the core complex of translation initiation
V[ACH]K[SP]
factor 3(eIF3), essential29
for translation;
HLVNKpart of a subcomplex
Motif for targeting
(Prt1p-Rpg1p-Nip1p)
CD44 to basolateral
that stimulates
membranes
binding of mRNA and tRNA(i)Met to ribosomes eukaryotic 43S preinitiation complex (1e-04)
0.004
8
PRP6: Splicing factor, component of the U4/U6-U5 A[AMK]..[VDH]A
snRNP complex
29
0.006
10
RPS11B: Protein component of the small (40S) ribosomalKK[AV]
29 and
RKK.[ST]
ZIP
colikinase
S17 and
phosphorylation
rat S11 ribosomalmotif
proteins
0.005
10
HHT1: One of two identical histone H3 proteins (seeGS..[KEH][AEH]
29 forS..[ED]
chromatin assembly,
Casein
involved
kinase
II substrate motif
telomeric and HM silencing; regulated by acetylation, methylation,
establishment
and mitotic
and/or
phosphorylation
maintenance of chromatin architecture
Y (1e-10) 0.006
9
FUN12: GTPase, required for general translation initiation
V[KT].[DFW]G
by promoting Met-tRNAiMet
29 binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2
translation (0.001)
0.004
9
[ACQ]A..[VHI]A
nuclear
transcription
mRNA
of asplicing,
reporter gene
Y
0.005
9
K..[WHV]D
mRNA
transcription
processing
of a reporter
(1e-04)
gene
0.005
10
oshea_spindle_pole
Q[IHM]D[KLH]
29 Q[MLVI]DG..[DE]
CLV_TASPASE1
0.005
9
oshea_mitochondrion
ML[RGK]
29 LRT
Y
Y
0.006
10
oshea_ER
[ERC]..RT
29
0.006
10
oshea_endosome
L[NSA][PFH]E
29
Y
endosome (1e-17)
0.006
10
oshea_bud
[LKR]N..[NHY]G
29 N..Y
FRIP PTB domain binding motif
bud (1e-10)
0.006
10
S.[QLD]T
29 [KR]STQT
Light chain 8 of dynein binding motif
spindle (1e-13)
0.007
9
matsuyama_Nucleus
A.[VAY]A
29 A.AA.VP....VP........P
PLU-1 transcription factor binding motif in BF-1 and PAX9
0.007
10
matsuyama_ER
G..I[GFT]
29 D[DE].G..[VI][TS]
DNA polymerase interaction motif
Y in Cdc27
Y
0.007
10
matsuyama_Cytosol
[KNY]L[RCM]G
29 LFG
Y
0.007
10
[SMN]R..Q[NVL]
29
0.007
10
[TLG]L..I[IND]
29
Golgi apparatus (0.001)
0.007
10
DS.I[SLM][SKL]
29
regulation of gene expression, epigenetic (0.01)
0.006
9
Q..[SDN]T
29 P.Q..D
diploid null mutant
LIG_TRAF2_2
displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
10
S[INQ]K
29 RRK.S.KR
diploid null mutant
PKCgamma
displays delayed
kinasepremeiotic
phosphorylation
DNA synthesis
site (peptide
and reduced
screen)
efficiency of meiotic nuclear division
Y
0.005
9
GIM3: Subunit of the heterohexameric cochaperone [SLH]A.[KAV]P
specifically
APAP
Motif forand
hydroxylation
transfers target
of proteins
Pro residues,
to it
which can further be modified with arabinogalactan
cell cycle (1e-05)
0.005
10
YPT6: GTPase, Ras-like GTP binding protein involved inL..T[SVG]
29 for
LP.TG
C-terminalvesicles
sortingwith
signal
the late
which
Golgi,
targets
Y maturation
surface
of the
proteins
vacuolar
ofcarboxypeptidase
StaphylococcusY;aureus
has similarity
to
vesicle-mediated
thetocell
the wall
human
peptidoglycan;
GTPase,
transport
Rab6Sortase
(1e-10)cleaves between Thr andY Gly and C-termini
0.005
is used for crosslinking
9
in cell wall
RIC1: Protein involved in retrograde transport to the cis-Golgi
L..L[TRD]
29
0.006
10
RIC1: Protein involved in retrograde transport to the S[QDS].L[KET]
29 S[ST]
with Rgp1p that actsMDC1
as a GTP
BRCT
exchange
domain
factor
binding
for Ypt6p;
motif
Yinvolved in transcription of rRNA and ribosomal protein genes
0.005
10
Q..K[NRT] repair (with Rad18p),
29 KR
CLV_PCSK_PC1ET2_1
silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)
Y
0.005
10
GET1: Subunit of the GET complex; required for the retrieval
I..L[QYI]
0.005
9
D..[LNQ]S
cell cycle (1e-05)
0.005
10
GIM4: Subunit of the heterohexameric cochaperoneDDL[NTM][EFP]
to it
0.005
10
RPN4: Transcription factor that stimulates expression of proteasome
S[NTK]N genes; Rpn4p29
levels S[ST]
are in turn regulatedMDC1
by the 26S
BRCT
proteasome
domain binding
in a negative
motiffeedback control mechanism; RPN4 is transcriptionally regulated
chromosome
by various
organization
stress responses
10
V.[ILV]I
29
MFS_1
1.E-03
-0.6
Y
0.018
10
S[DQP]Ssynthetases (Mes1p
28 and
R.S.S.P
Gus1p), delivering14-3-3
tRNA tobinding
them, stimulating
motifs, Ser
catalysis,
must be
andphosphorylated
ensuring
Pkinase
the cytoplasm;-3.9
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-13)
0.005
10
SAS10: Component of the small (ribosomal) subunitS[MQN][DLK]S
28for pre-18S
SQ rRNa processing;
ATMessential
kinase nucleolar
substrateprotein
motif that, when overproduced,
Pkinase
disrupts silencing
1.E-18
-2.9
Y
0.006
10
HHT1: One of two identical histone H3 proteins (seeKP..[KFV][KHA]
28 forKP..[QK]
chromatin assembly,
LIG_SH3_4LIG_SH3_4
involved in heterochromatin-mediated telomericHistone
-2.8
methylation,
establishment
and mitotic
and/or
phosphorylation
maintenance of chromatin architecture (1e-07) 0.006
9
LSP1: Primary component of eisosomes, which are largeP[PKE]P
28at theQHR.P[PL]PP[GS]H[RH]
Motif
withrecognized
endocytosis,by
along
GYF
with
domains
Pil1pY
and Sur7p; Pkinase
null mutants show activation
1.E-02 of Pkc1p/Ypk1p
-2.3
stress
phosphotransferase
resistance pathwaysactivity, alcohol group as acceptor (0.01)
Y
0.005
10
UBP15: Ubiquitin-specific protease that may play a role A.[TSL]S
28
Pkinase
1.E-03
-2.1
0.005
10
NOC4: Nucleolar protein, forms a complex with Nop14p ES[SNA]
and nuclear
S[ST]
MDC1 BRCT
subunits
WD40
1.E-04
-1.5
nucleolus (1e-29)
0.005
8
D.[AEL]V
28 SD.E
RRM_1
1.E-08
-1.4
0.006
10
E[KVQ]P
28 VP
Interleukin converting enzyme protease zf-C2H2
1.E-04
-1.4
Y
0.006
10
E..[DLM]L
28
BRCT
1.E-04
-1.4
0.006
10
A.[RKD]L
28 DALDL
the U3 snoRNA that14-3-3
is involved
binding
in processing
motif inofExoS
pre-18S rRNA
WD40
1.E-06
-1.4
Y
0.005
9
FAF1: Protein required for pre-rRNA processing and[QGP]G[LNA]K
28 GAKRH
HISTONE_H4 PATTERN
WD40
1.E-04
-1.3
nucleolus (1e-16)
0.005
9
[REK]G..[IKA]P
-1.3
0.006
10
NL.[LP][RS]K
Y
Y
E[KEA]A[EKT]
Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory
exocyst
vesicles(1e-04)
to active sites of exocytosis
DIP2: Nucleolar protein, specifically associated with[KPF]D..[TGA]K
D..G
complex
motif
known
thatas
binds
the small
phosphate
subunit in
(SSU)
GDP
processome,
and GTP binding
required proteins
for 18S rRNA biogenesis, part of the
rRNA
activeprocessing
pre-rRNA processing
(1e-18)complex
Y
Y
protein_40_YGR128C
oshea_nucleus
yeast-1036_GO-0005739
yeast-1721_GO-0016043
protein_40_YJL010C
yeast-207_GO-0006974
yeast-1216_GO-0009058
matsuyama_nucleolus
yeast-436_GO-0031323
yeast-335_GO-0016772
yeast-256_GO-0016462
protein_40_YPL131W
protein_40_YOL133W
protein_40_YLR293C
protein_40_YML085C
protein_40_YML007W
yeast-630_GO-0051244
protein_40_YGL105W
protein_40_YER102W
yeast-631_GO-0050794
protein_40_YOL139C
protein_40_YMR229C
protein_40_YER082C
yeast-468_GO-0051276
yeast-213_GO-0009719
protein_40_YIL094C
protein_40_YHR052W
protein_40_YPR144C
protein_40_YDR328C
protein_40_YDR224C
protein_40_YLR222C
protein_40_YLR129W
protein_40_YLR197W
protein_40_YOL069W
protein_40_YMR117C
yeast-256_GO-0016462
protein_40_YMR117C
yeast-939_GO-0051234
protein_40_YDR388W
yeast-207_GO-0006974
yeast-341_GO-0045449
yeast-322_GO-0005654
yeast-213_GO-0009719
yeast-215_GO-0007010
yeast-1340_GO-0044267
protein_40_YOL133W
protein_40_YHR196W
yeast-267_GO-0044265
protein_40_YPR103W
protein_40_YIL019W
protein_40_YGL105W
oshea_bud_neck
yeast-295_GO-0016192
yeast-1389_GO-0044260
protein_40_YLR129W
yeast-1216_GO-0009058
protein_40_YHR148W
yeast-1547_GO-0043283
protein_40_YMR125W
protein_40_YLR186W
protein_40_YPL146C
protein_40_YNL272C
yeast-388_GO-0007275
protein_40_YGL105W
protein_40_YMR128W
protein_40_YGL207W
yeast-324_GO-0030528
protein_40_YOR310C
yeast-544_GO-0016070
protein_40_YMR047C
yeast-248_GO-0016072
protein_40_YDR060W
yeast-256_GO-0016462
yeast-1340_GO-0044267
protein_40_YJR066W
oshea_nucleus
yeast-1074_GO-0044428
yeast-921_GO-0006810
yeast-856_GO-0009059
yeast-799_GO-0043233
yeast-799_GO-0031974
yeast-661_GO-0050789
yeast-648_GO-0050791
yeast-630_GO-0051244
yeast-596_GO-0044425
yeast-548_GO-0051641
yeast-523_GO-0030529
yeast-470_GO-0006259
yeast-424_GO-0006950
yeast-388_GO-0007275
yeast-371_GO-0009056
yeast-358_GO-0044248
yeast-358_GO-0044248
yeast-341_GO-0045449
yeast-322_GO-0005654
yeast-304_GO-0019752
yeast-304_GO-0006082
yeast-274_GO-0005840
yeast-267_GO-0000003
yeast-262_GO-0031224
yeast-252_GO-0006886
yeast-240_GO-0006807
yeast-238_GO-0017111
yeast-235_GO-0009653
yeast-235_GO-0009653
yeast-235_GO-0009653
yeast-235_GO-0000902
yeast-235_GO-0000902
yeast-235_GO-0000902
yeast-222_GO-0009308
yeast-215_GO-0005694
yeast-203_GO-0005975
ubiquitin_peng2003
protein_40_YPR144C
protein_40_YPR120C
protein_40_YPR110C
protein_40_YPR080W
protein_40_YPL240C
protein_40_YPL240C
protein_40_YPL240C
protein_40_YPL209C
protein_40_YPL153C
protein_40_YPL153C
protein_40_YPL146C
protein_40_YPL126W
protein_40_YPL076W
protein_40_YOR133W
protein_40_YOL139C
protein_40_YOL135C
protein_40_YOL086C
protein_40_YOL077C
protein_40_YOL013C
protein_40_YOL001W
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
[LTH]L.[AHW]S
1.E-04
of pre-18S
-1.3
rRNA
0.005
I..[AKE]R
28 [KR]R
CLV_PCSK_KEX2_1
Helicase_C
1.E-03
-1.3
0.006
A.[ALG]K
28
Helicase_C
1.E-02
-1.2
0.006
P[PDY]K
28 P..P.K
SH3 binding motif for Crk, general
Helicase_C
1.E-02
-1.1
Y
0.006
NOP9: Essential component of pre-40S ribosomes N[EVM]..D[DQT]
28 of 35S pre-rRNA and hence formation of 18S rRNA; binds RNA in vitro and
WD40
-1.1
nucleolus (1e-15)
Y
0.005
V[GAV]L
28 P[MVLIRWY]V[MVLIAS][LM]
LIG_HP1_1LIG_HP1_1
MFS_1
1.E-03
-1.1
0.005
L.[DQN]I
28
BRCT
1.E-06
-1
0.006
biosynthesis
I..N[LSN]
28
HEAT
1.E-02
-1
cell cycle (1e-09)
0.006
matsuyama_nucleolus
[TKS][PG]GR
28 GGRGG
Arginine methyl transferease substrate motif
Helicase_C
(PRMT1)
1.E-09
-1
nucleolus (1e-20)
0.007
TA[APQ]
28 P[TS]AP
LIG_PTAPLIG_PTAP
Zn_clus
1.E-06
-0.9
0.006
[NDP]Q[PHC]Y
groups
28
HATPase_c
1.E-03
-0.9
T[LYK].[NFH]T
28
Helicase_C
1.E-06
-0.9
0.006
DS[DNEQ][DKA]E
coli L18S[DE][DE]E
BARD1
proteins;
BRCT
bindsdomain
5S rRNAbinding
and is required
motif for 60SDEAD
subunit assembly 1.E-02
-0.9
0.004
P.L[KVR]
28(SCF);
P.L
required for Gic2p,Motif
Far1p,
in Sic1p
C-Fosand
forCln2p
protein
degradation;
instabilitymay tether Cdc34p
conjugating enzyme
-0.9 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(1e-10)
of SCF
Y
0.006
E..[KQP]A
IBN_N
1.E-09
Yrp4p, Yrb30p,
-0.9 Cse1p
nucleocytoplasmic
transport
homolog
(1e-14)
0.005
L[YKQ]..I[ERY]
28 polymerizes
IY
cFGR and Csk kinase phosphorylation site (peptide
HEAT screen) 1.E-03
-0.8
0.006
A[ADN].A[DNK]
tolerance; activated by H2O2 through the multistep formation of disulfide bonds
HEAT
and transit from the
1.E-02
cytoplasm to-0.8
the nucleus;
nucleoplasm
mediates resistance
part (1e-08)
to cadmium
Y
0.006
I.E
28 D..IYE
Lyn kinase phosphorylation site (peptide screen)
Zn_clus
1.E-06
-0.7
Y
0.006
[SRH]K.K[ST]
synthetases (Mes1p
the cytoplasm;-0.7
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-08)
0.006
R[EVL][LTA]A
28 andC[SA]DSR[LIVM].[AP]
has similarity to rat PROK_CO2_ANHYDRASE_1
PATTERNHelicase_C
1.E-02
-0.7
0.006
I.E
28 D..IYE
Lyn kinase phosphorylation site (peptide screen)
Zn_clus
1.E-06
-0.6
Y
0.006
CDC33: Cytoplasmic mRNA cap binding protein; the eIF4E-cap
N.[KDR]R
complex is responsible
28 for[KR]R
CLV_PCSK_KEX2_1
mRNA translation via interactions with thePkinase
-0.6 orprotein
0.005
RRP5: Protein required for the synthesis of both 18S[FRI][GRE].AR
28 is[AG]R
Protease
of 18Smatriptase
rRNA and N-terminal
proteaseregion
site is required
Helicase_C
component of -0.6
small ribosomal
nucleolus
subunit(1e-09)
(SSU) processosome
Y
0.005
A[IVL].L[LPE]
28 the
DALDL
U3 snoRNA that is14-3-3
involved
binding
in processing
motif inofExoS
pre-18S rRNA
Y
WD40
1.E-02
-0.6
nucleolus (1e-16)
Y
0.006
SK[KNC][IRE]
28
HEAT
1.E-02
-0.5
0.006
L[SRL]Q
28 ARKGSLRQ PKC alpha kinase substrate motif
Y
BRCT
1.E-05
-0.5
0.006
IA.[KAL][NAT]
-0.5
Y
0.006
[DEN]V.A[RKW]
-0.5
0.005
NOC4: Nucleolar protein, forms a complex with Nop14p DL[VEL]
and nuclear
WDLexport of 40S ribosomal
Binding motif
subunits
for AP-2 and clathrin heavy chain
WD40
ear
1.E-02
-0.3
Y
0.005
SKP1: Evolutionarily conserved kinetochore protein that is
KK[DLI]
part of multiple protein complexes,
including the SCF
Insulin
ubiquitin
receptor
ligase kinase
complex,substrate
the CBF3 motif
complex thatF-box
DNA, and the RAVE
-0.3 complex
ubiquitin
that regulates
ligase assembly
complexof(1e-15)
the V-ATPase
0.005
HTB1: One of two nearly identical (see HTB2) histone H2B
G..A[KPN]
subtypes required for chromatin
28 GR.A
Protease function;
tPA proteolytic
Rad6p-Bre1p-Lge1p
site
mediatedHistone
1.E-06
transcriptional
-0.3activation,
DNAmeiotic
metabolism
DSB formation
(1e-05)
and H3 methylation
Y
0.005
K..K[RLC]
28 KR
WD40
1.E-08
-0.1
0.005
DIP2: Nucleolar protein, specifically associated with theR..[FKH]E
U3 snoRNA, part of the large
R..K
complex
SH3
known
binding
as the
motif
small
forsubunit
GADS(SSU)
SH3processome,
recognizing
WD40
required
slp-76 for
motif
18S(nonconventional)
rRNA
1.E-03
biogenesis,-0.1
part of the
rRNA
activeprocessing
pre-rRNA processing
(1e-28)complex
0.005
[LVR]T.[DFE]G
WD40overexpression
1.E-02
causes spindle
0 orientation
smalldefects
Y
0.006
D..Q[EKD]
Ndc80 complex
28
SMC_N
spindle checkpoint
1.E-03
0.1
microtubule
clustering
0.005
KK[ILMV]
Ndc8028
SMC_N
spindle checkpoint
1.E-02
activity and0.1
kinetochore
condensed
clustering chromosome (0.01)
0.005
M.G[DRC]
28
E1-E2_ATPase
1.E-05
0.2
Y
0.006
K..N[EMS]
Ndc8028
SMC_N
spindle checkpoint
1.E-02
activity and0.2
Y
0.005
[SNR]A.T[GKF]
28
E1-E2_ATPase
1.E-02
0.3
0.006
RVS167: Actin-associated protein, subunit of a complex Q.[REI]P
Pkinase
or osmotic stress;
1.E-02
homolog of0.3
mammalian
cellamphiphysin
cortex part (0.01)
0.005
[NFG]L.[ENM]E
28
SMC_N
1.E-04
0.4
0.006
[DNI]G.E[KSQ]
28
zf-C2H2
1.E-02
0.5
0.006
nucleoplasm
L[EQD]..[NAT]A
28
Bromodomain
1.E-02
0.8
nucleoplasm (1e-63)
0.006
D.[FNG]N
28 F.D.F
LIG_AP2alpha_1
BRCT
1.E-04
0.8
Y
0.006
[DNK]DL[NDE]
28 DLL
Binding motif for clathrin heavy chain ear SH3_1
1.E-02
1.1
0.006
AA..[DRW][ADT]
28
Ribosomal_60s
1.E-04
1.2
translation (1e-18)
0.006
T.[VCY]L
28(SCF);
T.Y
required for Gic2p,MEK
Far1p,
phosphorylation
Sic1p and Cln2p of
degradation;
MAPK activation
may tether
site
Cdc34p
conjugating enzyme
1.2 or E2)
ubiquitin
and Cdc53p
ligase
(a cullin)
complex
subunits
(1e-09)
of SCF
Y
0.005
D[AGK]..[IRK]L
WD40
1.E-03
1.2
nucleolus (1e-16)
Y
0.006
YP.[KSR]P[PLE]
28 P.[ST]P
Erk p44 MAP kinase phosphorylation
Y
site UQ_con
1.E-08
1.3
cellular macromolecule catabolism (1e-08)
0.005
T[ASQ]I[GQM]
Proteasome
1.E-10
1.3
0.004
FAF1: Protein required for pre-rRNA processing and 40S
G.[ERM]D
ribosomal subunit assembly
28 Q[MLVI]DG..[DE]
CLV_TASPASE1
WD40
1.E-07
1.3
0.005
L..[LIN]Ksynthetases (Mes1p
the cytoplasm; 1.3
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-16)
0.005
oshea_bud_neck
G..Q[EFY]
28
RhoGAP
1.E-04
1.4
bud (1e-25)
Y
0.005
[ILF][WIF]..AGQ
28
Ras
1.E-16
1.5
0.005
GP..[TGS]P[YGV]
28 GP
UQ_con
1.E-18
1.6
ubiquitin conjugating enzyme activity (1e-18)
0.006
DIP2: Nucleolar protein, specifically associated with[AYS]T..[YMK]D
1.E-03
biogenesis,1.8
part of the
nucleolus
active pre-rRNA
(1e-13)
processing complex
0.005
biosynthesis
G..[FGR]V
28 G.G..G
Phosphate, FAD, NADH, binding motif tRNA-synt_2b
1.E-03
1.9
0.006
IMP3: Component of the SSU processome, which is
SG..[NDW][GLS]
28 SG.G
Glycosaminoglycan
interacts with Mpp10p
attachment
and mediates
siteinteractions
WD40
of Imp4p and Mpp10p
1.E-07
with U3 snoRNA
1.9
nucleolus (1e-20)
0.006
GT..[SKY][VRY]
Pkinase
1.E-08
2
0.006
STO1: Large subunit of the nuclear mRNA cap-binding
[SCR]K.A[TFM]
28 Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear
RRM_1
mRNA degradation
1.E-03
and telomere2maintenance;
RNA binding
orthologous
(1e-07)
to mammalian CBP80
Y
0.005
EMG1: Protein required for the maturation of the 18S rRNA
K.[LWK]A
and for 40S ribosome 28
production; associated with spindle/microtubules; nuclear localization dependsWD40
1.E-03
with Nop14p;2 may bind
rRNA
snoRNAs
processing (1e-28)
Y
0.005
NOP53: Nucleolar protein; involved in biogenesis of [REI][DEW].KP
28 interacts
FKPY
TLA binding
factorsmotif
Cbf5pinand
Brinker
Nop2p;transcription
null mutant isfactor
viable
Pkinase
but
for growth
bindingis TLA
severely
1.E-05
domain
impaired
in Groucho
2.2
Y
0.005
SEC2: Guanyl-nucleotide exchange factor for the small L.S[GDH]
28cytoplasmic
WLNSvesicles; essential
Lipid binding
for post-Golgi
motifvesicle
in C-terminus
transport of Apolipoprotein
Pkinase
AII
1.E-16
2.2
Y
0.005
development
E.[IYE]I
28 EEEIYEEIE
cFPS/FES kinase phosphorylation site
Pkinase
1.E-02
2.4
0.006
Y..[RGI]G
synthetases (Mes1p
28 and
Y..[ILM]
Gus1p), deliveringSH2
tRNAligand
to them,
FOR
stimulating
Shc group
catalysis,
3 (phospho-peptide)
and ensuring
Pkinase
their localization
Syk also to1.E-10
the cytoplasm; 2.7
also bindsprotein
quadruplex
kinase
nucleic
activity
acids (1e-10)
Y
0.006
G..K[VKF]
28 predominantly
G..G..K nucleolar
Sulfonate
in distribution,
donorrequired
bindingforsite
18SinrRNA
sulfotransferases
synthesis WD40
1.E-03
2.9
0.005
SPT16: Subunit of the heterodimeric FACT complex [LIQ]H[SQC]K
Pkinase
1.E-04
nucleosome
3 structure
0.005
H.[CAI]P
28 QHR.P[PL]PP[GS]H[RH]
Motif recognized by GYF domains
zf-C2H2
1.E-13
3.1
Y
0.006
NOP58: Protein involved in pre-rRNA processing, 18S rRNA
G..[VYK]V
28synthesis;
G..G..K
component of Sulfonate
the small subunit
donorprocessome
binding sitecomplex,
in sulfotransferases
which is required
WD40for processing
1.E-03
of pre-18S rRNA
3.1
0.005
RNA metabolism
RL[DVW]
GoLoco motif, a G alpha binding motif
WD40
1.E-04
3.4
0.006
NUP116: Subunit of the nuclear pore complex (NPC)IR.[LHF][AYV]
of the R.L
CyclinGLFG
A motif
motif
that
that
binds
interacts
cdk2
with
complexes
mRNA exportIBN_N
with karyopherin
3.5
transport (1e-14)
0.006
rRNA metabolism
R[ENY][LCT]A
28
DEAD
1.E-08
3.8
0.006
[DRI]V[AVK]A
28 subunit biogenesis; involved in nuclear export of pre-ribosomes; required
Helicase_C
3.9 of cytoplasm
human CAATT-binding
organization
Y
0.006
[PAC]T.I[QM]
28
DEAD
1.E-09
4.2
0.006
[ILMV]K..NI[LYF]
28
Pkinase
1.E-33
5.8
0.006
G[LFH]..[KCV]L
28 that controls growth in response to nutrients by regulating translation, transcription,
GATA ribosome1.E-05
7 transport
regulation
and autophagy;
of nitrogen
involved
utilization
in meiosis (1e-05)
Y
0.006
oshea_nucleus
C.[NYI]C
28 C..C
zf-C2H2
1.E-09
7.9
0.006
nuclear part
[HQP][RHY].GR
28 [AG]R
Helicase_C
1.E-21
9.9
0.006
transport
LN..[FIE][SMW]S
28
0.006
[IY]A.S[RLY]R
28 [KR]R
CLV_PCSK_KEX2_1
translation (1e-05)
0.005
organelle lumen
F..[FYS]F
28 F.D.F
LIG_AP2alpha_1
Y
0.006
membrane-enclosed lumen
F..[FYS]F
28 F.D.F
LIG_AP2alpha_1
Y
0.006
DA.[IFP][DAY]
28
0.006
D[APN].I[DVI]
28
0.006
KL.[NSP]A[THM]
28
0.006
membrane part
F..[VYF]F
28 F.D.F
LIG_AP2alpha_1
Y
0.006
[NTI]E.[KLQ]T
28 [ST]E
Y
0.006
[EKG]AA[KHN]K
28
0.006
DNA metabolism
[VKF]N[KQY]V
28 Y[QVY]N[FQY] SH2 ligand for Fyn (Tyr must be phosphorylated)
0.006
response to stress
K..[SPY]E
28 [ST]E
Y
0.006
development
HR.[IEH][PGY]
28
0.006
catabolism
LG..[TNY][TKM]
28 [ILVM]LG..P
LIG_RRM_PRI_1
catabolism (1e-47)
0.006
cellular catabolism
[FDH][KFH].IA
28
0.006
cellular catabolism
DN..[RTI][ICW]
28
0.006
Q[DYQ].T[LEK]
0.006
nucleoplasm
[STF]NA[NME]
28
nucleoplasm (1e-45)
0.006
H[LMK]G[NHV]
28 P[GSTAN][DENQGAPK].[LIVMFP][HT][LIVMYAC]G[HNTG]
AA_TRNA_LIGASE_I PATTERN
0.007
H[LMK]G[NHV]
28 P[GSTAN][DENQGAPK].[LIVMFP][HT][LIVMYAC]G[HNTG]
AA_TRNA_LIGASE_I PATTERN
0.007
ribosome
K..H[EYC]
28
0.006
reproduction
NK.[NPM][ILQ]
28
Y
0.006
L..V[AQC]
28
Y
0.006
intracellular protein transport
[PFQ]G[SAW]N
28
intracellular protein transport (1e-31)
0.006
A[NKQ]G[EIF]
28
Y
0.006
L[KGA][NWA]K
28 GAKRH
HISTONE_H4 PATTERN
0.006
morphogenesis
E.[QHV]Q
28 YE.[IV]
Y
0.006
morphogenesis
L[AEM]..[AHG]SK
28
0.006
morphogenesis
P.[APM]T
28
0.006
E.[QHV]Q
28 YE.[IV]
Y
0.006
L[AEM]..[AHG]SK
28
0.006
P.[APM]T
28
0.006
amine metabolism
VD.[LDK][YMK]
28 HAVDI
N-Cadherin ligand
Y
0.006
chromosome
D[YSG].[SID]D
28
chromosome (1e-61)
0.006
K.[SAF]A
28 RKK.[ST]
0.006
ubiquitin_peng2003
L[EVD]..[DGH]FE
28
0.005
NOC4: Nucleolar protein, forms a complex with Nop14p AR[IGE]
and nuclear
[AG]R
Proteasesubunits
0.005
CLB5: B-type cyclin involved in DNA replication during SL..[DEH]E
Y
0.005
[APR]I[SD]G
I and III
28 INPISGQ
N-Cadherin ligand
0.005
TEF1: Translational elongation factor EF-1 alpha; also encoded
A..[DQF]K
by TEF2; functions28
in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
0.005
[EMI]AR[KSM]
28of Hsf1p;
[AG]R
docks with Tom70p
Protease
for mitochondrial
matriptasepreprotein
proteasedelivery;
site promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
0.005
A.[TQN]F
Y
0.005
S[LAH].V[EIH]
0.005
E[EHS]..[GNA]F
attachments; helps
28 maintain condensed chromosomes during anaphase and early telophase; associates with Sli15p, which promotes Ipl1pspindle
association
midzone
with mitotic
(0.001)
spindle
0.005
I.[KYP]S
to DNA damage; 28
DNA
a role
integrity
in initiation
checkpoint
of DNA replication
(0.001)
0.005
V.R[KTI]
to DNA damage; 28
protein
a role kinase
in initiation
activity
of DNA(0.01)
replication
0.005
NOP53: Nucleolar protein; involved in biogenesis of theE..[ENA]D
60S subunit of the ribosome;
Y
0.005
NAN1: U3 snoRNP protein, component of the small (ribosomal)
[EPF]R.I[LRT]
28
containing U3 snoRNA; required for the biogenesis of18S rRNA
nucleolus (1e-14)
0.006
F[VFI]..[LAY]I
28(GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein
0.005
[DMG]I..[AEG]V
28
carboxylic
ADP-ribosylated
acid by
metabolism
diphtheria toxin
(0.01)
0.005
CDC33: Cytoplasmic mRNA cap binding protein; theE[ETS].P[LDS]
28 for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p)
0.006
MED7: Subunit of the RNA polymerase II mediator [QDP]Q..[QYA]N
28
0.005
D[GCH]V[NEF]
28 D.D.[TV]
Motif inofPRS1
acetaldehyde
and PRS-2
to ethanol,
required
the last
forstep
phosphatase
in the glycolytic
activity
pathway
and salt stress response
0.004
RE[LTR][ANH]
28to defects
MR[DE][IL]
in rRNA processing
TUBULIN_B_AUTOREG
and a block in the assembly
PATTERN
of large ribosomal subunits; possesses a sigma(70)-like RNA-binding
nucleolus
motif(1e-11)
0.006
HRD1: Ubiquitin-protein ligase required for endoplasmicD.[PGQ]A
28
amino
withacid
Hrd3p;
metabolism
contains an H2
(0.01)
ring finger
0.006
E[AVC].[KHV]A
28
complex) phosphorylates Pho4p and Swi5p; deletion of Y
PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance
0.005
oshea_nucleus
mitochondrion
9
10
9
10
10
9
9
9
10
9
9
9
8
10
9
10
10
10
10
9
10
10
10
10
10
9
10
9
9
10
10
9
10
8
9
9
10
8
9
10
8
10
8
10
9
10
10
9
8
9
10
10
10
8
9
9
10
10
10
10
10
10
10
9
10
10
10
9
9
9
10
10
10
9
10
9
8
9
9
7
10
10
8
10
9
9
10
9
9
10
10
8
9
8
10
8
10
10
10
10
10
10
10
9
9
10
10
9
10
10
10
8
9
10
10
10
9
10
9
10
10
9
9
8
9
10
10
10
9
7
8
10
10
10
protein_40_YNR053C
protein_40_YNL307C
protein_40_YNL289W
protein_40_YNL289W
protein_40_YNL178W
protein_40_YNL154C
protein_40_YNL154C
protein_40_YNL132W
protein_40_YNL096C
protein_40_YMR304W
protein_40_YMR236W
protein_40_YMR186W
protein_40_YMR125W
protein_40_YMR093W
protein_40_YMR047C
protein_40_YMR012W
protein_40_YMR001C
protein_40_YML049C
protein_40_YML010W
protein_40_YML010W
protein_40_YML007W
protein_40_YLR347C
protein_40_YLR347C
protein_40_YLR347C
protein_40_YLR180W
protein_40_YLR129W
protein_40_YLL034C
protein_40_YLL011W
protein_40_YKL203C
protein_40_YKL203C
protein_40_YKL203C
protein_40_YKL203C
protein_40_YKL180W
protein_40_YKL172W
protein_40_YKL145W
protein_40_YKL145W
protein_40_YKL104C
protein_40_YKL104C
protein_40_YJR066W
protein_40_YJL187C
protein_40_YJL130C
protein_40_YJL106W
protein_40_YJL092W
protein_40_YJL092W
protein_40_YJL074C
protein_40_YJL074C
protein_40_YIL094C
protein_40_YIL094C
protein_40_YIL094C
protein_40_YIL094C
protein_40_YIL094C
protein_40_YIL061C
protein_40_YIL061C
protein_40_YIL061C
protein_40_YIL035C
protein_40_YHR197W
protein_40_YHR196W
protein_40_YHR079C
protein_40_YHR064C
protein_40_YHL034C
protein_40_YGR218W
protein_40_YGR162W
protein_40_YGR128C
protein_40_YGR092W
protein_40_YGR092W
protein_40_YGR040W
protein_40_YGR034W
protein_40_YGL246C
protein_40_YGL195W
protein_40_YGL179C
protein_40_YGL179C
protein_40_YGL137W
protein_40_YGL106W
protein_40_YGL106W
protein_40_YGL106W
protein_40_YGL103W
protein_40_YGL019W
protein_40_YFR034C
protein_40_YFR034C
protein_40_YFR014C
protein_40_YFR010W
protein_40_YFR010W
protein_40_YER177W
protein_40_YER133W
protein_40_YER118C
protein_40_YER110C
protein_40_YER021W
protein_40_YER018C
protein_40_YEL034W
protein_40_YDR510W
protein_40_YDR447C
protein_40_YDR427W
protein_40_YDR388W
protein_40_YDR388W
protein_40_YDR381W
protein_40_YDR365C
protein_40_YDR324C
protein_40_YDR303C
protein_40_YDR224C
protein_40_YDR224C
protein_40_YDR174W
protein_40_YDR174W
protein_40_YDR167W
protein_40_YDR145W
protein_40_YDR145W
protein_40_YDR145W
protein_40_YDR064W
protein_40_YDR025W
protein_40_YDL185W
protein_40_YDL179W
protein_40_YDL148C
protein_40_YDL140C
protein_40_YDL043C
protein_40_YDL029W
protein_40_YDL014W
protein_40_YDL013W
protein_40_YCR009C
protein_40_YBR247C
protein_40_YBR247C
protein_40_YBR247C
protein_40_YBR200W
protein_40_YBR200W
protein_40_YBR154C
protein_40_YBR142W
protein_40_YBR079C
protein_40_YBR048W
protein_40_YBR017C
protein_40_YBR009C
protein_40_YBL072C
protein_40_YBL016W
protein_40_YAL032C
protein_40_YAL032C
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
NOG2: Putative GTPase that associates with pre-60S
A[RKV]..[ATS]K
28
and is required for their nuclear export and maturation
0.006
0.006
0.005
0.005
K[AKI].R[DIG]
28
Y
0.006
YCK2:

Run Bins Run Details Motif Z- score Known Match

Transcription

Similar documents