Summer 2010 - Medical Alumni Association

Transcription

University of Maryland
Summer 2010 • Volume 95 • Number 1
Transforming
Medicine
Bulletin Editorial Board
Joseph S. McLaughlin, ’56
Chairman
Roy Bands, ’84
Frank M. Calia, MD, MACP
Nelson H. Goldberg, ’73
Donna S. Hanes, ’92
Joseph M. Herman, ’00
Harry C. Knipp, ’76
Morton D. Kramer, ’55
Morton M. Krieger, ’52
Jennifer Litchman
Philip Mackowiak, ’70
Michael K. McEvoy, ’83
Martin I. Passen, ’90
Gary D. Plotnick, ’66
Larry Pitrof
Maurice N. Reid, ’99
Ernesto Rivera, ’66
Jerome Ross, ’60
Luette S. Semmes, ’84
James Swyers
MedicineBulletin
Discovery & Innovation 10
Research Capable of Transforming Medical Care
Maryland research has surged over the past two decades.
In the short term it has dramatically expanded the school’s
physical plant, and insiders—including alumni—have
enjoyed Maryland’s elevated stature among the nation’s 133
medical schools. In the long run, however, these initiatives are undertaken to relieve suffering, eradicate disease,
and improve the health of every individual on our planet.
In this feature, writer Jim Swyers provides updates on four
game-changing research projects.
10
Medical Alumni Association
Board of Directors
(cover illustration: Fotolia)
Otha Myles, ’98
President
Tamara Burgunder, ’00
President-Elect
Vice President
Victoria W. Smoot, ’80
Treasurer
George M. Boyer, ’83
Secretary
Protagoras N. Cutchis, ’83
Jerome Ross, ’60
Luette S. Semmes, ’84
Elizabeth Tso, ’79
Directors
Geoffrey B. Liss, ’76
Richard Keller, ’58
Robert M. Phillips, ’82
Robert R. Rosen, ’49
Honorary Regional Vice Presidents
Ronald Goldner, ’65
Peter MacArthur, ’11
Dr. E. Albert Reece, Dean
Ex-Officio
Larry Pitrof
Executive Director
University of Maryland School of Medicine
Board of Visitors
Michael E. Cryor
Chair
Peter G. Angelos, Esq.
Morton D. Bogdonoff, MD
Jocelyn Cheryl Bramble
Frank C. Carlucci, III
William M. Davidow, Jr., Esq.
Robert C. Embry, Jr.
Robert E. Fischell, ScD
Ronald E. Geesey
Ronald Goldner, ’65
Stewart J. Greenebaum
Willard Hackerman
John R. Kelly
Harry C. Knipp, ’76
Carolyn McGuire-Frenkil
Edward Magruder Passano, Jr.
Timothy J. Regan
Melvin Sharoky, ’76
Richard L. Taylor, ’75
features
University of Maryland Medical Alumni Association & School of Medicine
An Extra Mile for the Extra Edge
Epidemiology and Public Health
15
departments
Dean’s Message
2
News & Advances
4
20
Recollections 34
Faculty News
Student Activities
Advancement
35
36
3239
Managing Wealth
40
In Memoriam 42
Class Notes
Supported by $15 million in research funding and now offering 12 degree programs, Maryland’s department of epidemiology and public health is out to shatter the perception
that this discipline is nothing more than abstract science. Its
58-member department, consisting of epidemiologists, biostatisticians, and behavioral and social scientists is laboring
to incorporate public health into virtually every professional
school on the Baltimore campus.
The 135th Medical Alumni Association
Reunion 24
Clinicopathological Conference, Crab Cakes
& Comradery
3
Remembered
15
The University of Maryland Medicine Bulletin, America’s
oldest medical alumni magazine, is jointly sponsored
by the Medical Alumni Association of the University of
Maryland, Inc., and the University of Maryland School
of Medicine.
The acceptance of advertising by this publication
does not in any way constitute endorsement or approval by the Medical Alumni Association or medical
school. Requests to reproduce articles should be made
to: Editor, Medicine Bulletin, 522 W. Lombard Street,
Baltimore, Maryland 21201-1636, or by email:
[email protected].
Subscriptions are $20 per year (domestic) and $25
(overseas)
For information on advertising, please contact:
The Medical Alumni Association of the University of
Maryland, Inc. email: [email protected]
Simon Bolivar, regarded as the George Washington of
South America, was this year’s subject during the historical Clinicopathological Conference—centerpiece of the
Medical Alumni Association’s annual reunion. The two-day
celebration included tours, lectures, and social events targeting classes ending in “0” and “5.”
Alumna Profile: Sangeeta Pati, ’90
A Singular Path
32
A prolonged hospital stay at age 16 due to a near fatal attack
of hepatic encephalitis would profoundly impact Sangeeta
Pati, ’90, in her pursuit of a balanced medical practice.
Today she is president and medical director of the Sajune
Institute for Restorative and Regenerative Medicine in
Orlando where her therapies combine conventional and
natural medicine for thousands of patients each year.
Editor-in-Chief
Larry Pitrof
Medical Editor
Morton M. Krieger, ’52
Design
Brushwood Graphics Design Group
Art Director
Nancy Johnston
Summer 2010 • Volume 95 • Number 1
dean’s message
I
Remembered
believe that we are on the verge of a second “Golden Age”
of biomedicine, one in which a new set of wonder tools and
innovative approaches to treating diseases and medical conditions, such as genomics, stem cells, structural biology, etc.,
will allow medicine to become much more personalized and
better targeted; so that it is not only more effective but far
less toxic to the patient. Just as antibiotics heralded in the
first Golden Age of medicine in the latter part of the 20th
Century by greatly extending life as well as quality of life
for people around the world, I believe these new tools and
approaches will allow us to live longer, happier, and more
productive lives.
This issue of the University of Maryland Medicine
Bulletin features five imaginative projects highlighting discovery and innovation at our medical school. I believe they
will catalyze fundamental changes at many different levels
in their respective fields and help transform the practice of
medicine and health care delivery in ways we cannot yet
imagine.
The first feature entitled “Discovery and Innovation”
presents four short vignettes of recently launched projects
E. Albert Reece, MD, PhD, MBA
Vice President for Medical Affairs, University of Maryland
by faculty and their collaborators that offer to transform
John Z. and Akiko K. Bowers Distinguished Professor and
how specific diseases or medical conditions are viewed and
Dean, School of Medicine
treated, as well as how whole fields of investigation are conActing President, University of Maryland Baltimore
ducted. Indeed, these innovative research projects have the
potential to catalyze literally “quantum leaps” not only in
their respective fields but in many related fields of biomedical research and clinical practice. More importantly, they offer to significantly accelerate the development of life-saving therapies for conditions where no acceptable treatments currently exist.
The second feature focuses on our department of epidemiology and public health, headed
by Jay S. Magaziner, PhD, professor and chairman. His department is redefining itself by a
method that not only changes the way students
view diseases and patients but also how they
ultimately will practice medicine and, hopefully, conduct research to improve the practice
of medicine.
Just as the discovery and development of
penicillin and other antibiotics in the late
1930s and early 1940s virtually eliminated
death from bacterial infections in the latter half of the 20th Century, I believe these types of investigations have the potential to alleviate a great deal of unnecessary deaths and human suffering in the
not-too-distant future, and that we are truly blessed to be able to witness the dawn of this second Golden
Age of biomedicine.
These innovative research projects have the potential
to catalyze literally “quantum leaps” not only in
their respective fields but in many related fields of
biomedical research and clinical practice.
Larry Anderson, PhD
Baltimore Teacher of the Year, serving as chairman of
the Maryland State Anatomy Board, and being named a
charter member of the University of Maryland School of
Medicine Academy of Educational Excellence.
In addition to serving as professor of anatomy and
neurobiology and course director for structure & development, Anderson continued his funded research with
graduate students and post-doctoral fellows. Two of his
research efforts were associated with reproduction—the
role of androgens in regulating various cellular and molecular characteristics involved in the growth, development, and differentiation of one compartment within the
follicle of the ovary, the granulosa cells; and a collaboration with the department of epidemiology and toxicology on the effect of paternal lead exposure on embryo
development and subsequent
generations.
Since he was a youngster,
Anderson had a passion for
race cars and was the owner
of a 1965 AC Cobra, 1964
Pontiac GTO, and 2005
GTO which he maintained
himself.
Survivors include wife
Shirley, two children, and
two grandchildren. The family has established a memorial fund to benefit medical
students. Gifts are warmly
received by the Medical
Alumni Association of the
University of Maryland,
Inc., 522 W. Lombard Street,
Baltimore, MD 21201-1636
or on our website:
www.medicalalumni.org.
Larry Anderson, PhD, anatomy instructor at Maryland
since the late 1970s, died unexpectedly at his home on
May 15. He was 62.
Born in a suburb of Detroit, Anderson received a
PhD in physiology and biochemistry from Wayne State
University in 1976. He came to Maryland later that year
as an NIH postdoctoral fellow in reproductive endocrinology in the department of physiology, working with
Cornelia Channing, PhD, and her study of the hormone
inhibin.
Upon completion of his fellowship, Anderson was
encouraged to apply for a faculty position in the department of anatomy. After teaching a seminar in the
department for one year, he was offered the position.
Anderson taught anatomy as
well as structure & development to freshmen students
for 30 years, serving as course
master for the past decade. It
is estimated that he instructed more than 4,500 medical
students—more than half of
the school’s living alumni—
during his tenure.
Alumni recall fondly Anderson’s words at the beginning of his anatomy course:
“This is your first patient.
I expect you to extend the
same respect to the cadaver
on the dissection table as you
will to patients who will later
fill your offices.”
They also remember
him for his compassion,
friendship, and enduring
encouragement. He also
advised them to maintain a
balanced perspective on life.
Anderson received countless
awards and honors, including being named the 2006
Alumni remember him for his compassion,
friendship, and enduring encouragement.
A memorial service has been
scheduled for Larry Anderson
on Thursday, September 16,
at 4:30 p.m., at Westminster
Hall. All are welcome.
E. Albert Reece, MD, PhD, MBA
Medicine Bulletin Summer 2010
[2]
[3]
news&advances
events
Shock Trauma Expanding
Vaginal Microbes Vary Among Healthy Women
in Different Ethnic Groups
T
A groundbreaking ceremony on May 13 featuring Maryland governor Martin O’Malley, state senator Francis X.
Kelly, and Baltimore Orioles icon Cal Ripken Jr., marked
the start of expansion for the R Adams Cowley Shock
Trauma Center. Considered phase IV of the medical center’s strategic facilities development plan, the nine story,
$160 million addition includes 10 state-of-the-art operating rooms and 64 new and replacement beds, as well as
another rooftop landing pad.
The present Shock Trauma Center opened in 1989,
and by 2008 was handling nearly 64,000 visits; this number is expected to grow to 80,000 by 2016. The State of
Maryland is contributing $50 million over five years, with
additional support coming from the federal government
and from medical center operating funds. Thirty-five million will be raised privately with help from Ripken, who
agreed to serve as honorary campaign chairman. Construction is expected to be completed by 2013.
events
A rendering of the Shock Trauma addition on Lombard Street
Mallott, Kaper Inducted into Academy of Educational Excellence
David B. Mallott, MD, and James B. Kaper,
PhD, were inducted into Maryland’s Academy of Educational Excellence in spring. The
academy was established in 2008 by Carolyn J.
Pass, ’66, and Richard M. Susel, ’66, to promote and reward superlative teaching. Mallott
is an associate professor of psychiatry and since
1997 has served as associate dean for medical
education. Kaper is professor and chair of the
department of microbiology and immunology.
Richard M. Susel, ’66, Carolyn J. Pass, ’66, James B. Kaper, PhD, David B. Mallott, MD, and
SOM dean E. Albert Reece, MD, PhD, MBA
events
Twaddell Awarded Firminger
Prize
William S. Twaddell, MD, an assistant professor in
the department of pathology, was awarded the 2010
Harlan I. Firminger Faculty Teaching Prize. The annual award recognizes a faculty member in the department for excellence in teaching. Twaddell’s research
interests include liver disease—primarily malignancies—as well as pancreatic and colorectal malignancies. The award was established two years ago by
Wilson A. Heefner, ’60. Firminger served as chair of
the department of pathology from 1958 to 1967.
William S. Twaddell, MD, with 2009 award winner Olga B. Ioffe, MD, department chair
Sanford A. Stass, MD, Patricia Heefner, and Wilson A. Heefner, ’60
[4]
he delicate balance of microbes in the
“We’ve found we can actuvagina can vary greatly among healthy
ally group women by the type
women, according to a new study led
of microbes they have in the
by the University of Maryland School
vagina,” says Ravel. “The study
of Medicine Institute for Genome Scishows that doctors should not
ences. Researchers hope further study
assume every woman is the
will lead to personalized reproductive
same. We may not need to per- Jacques Ravel, PhD
medicine for women, allowing doctors
sonalize reproductive medicine
to tailor each woman’s treatment and
down to the individual woman, but by which microbial
health maintenance strategies to her
group to which they belong. The information about each
individual microbial make-up.
woman’s vaginal microbial community could inform how
The study, published online the week of May 31
doctors treat her for vaginal conditions. It could help
in the journal Proceedings of the National Academy of
drive the development of better treatments to reestablish
Sciences, used genomics-based technologies to examine
vaginal health. Understanding these microbial communithe vaginal microbes in 400 women. The work, a colties could also help us determine which women might be
laboration between Maryland’s institute and researchers
at higher risk for infections.”
at the University of Idaho, is
Yeast infections or
the first in-depth, large-scale
bacterial
vaginosis cause
If we could identify women as being at a
molecular characterization
discomfort in patients
high risk for developing bacterial vaginoof vaginal microbial comand can have serious
munities. The research is an
sis, we could develop preventive methods health effects. About 25
example of an emerging field
to 30 percent of women
to lower the risk of infection.
of genomics, the study of the
have bacterial vaginosis
human microbiome. The huon any given day, and it
man microbiome refers to all of the microbes that live
is the most common vaginal infection that causes women
on and in the human body. Scientists believe these tiny
of reproductive age to visit their primary care physician.
organisms interact closely with the human genome and
“If we could identify women as being at a high risk for
play a critical role in human health and disease. In the
developing bacterial vaginosis, we could develop prevenvagina, these communities of microbes play a critical
tive methods to lower the risk of infection,” says Ravel.
role in maintaining and promoting a woman’s health
The study involved vaginal samples taken from 400
and in protecting her against disease. Vaginal microbes
women representing four ethnic groups equally: black,
provide protection mainly by producing lactic acid to
Hispanic, Asian and white. Ligia Peralta, MD, associate
create an acidic environment that is hostile to certain
professor of pediatrics and microbiology and immunolharmful microbes or infection.
ogy, collaborated with clinicians at Emory University
“The surprising finding here is that some women
to collect the tissue samples. Ravel and his group at the
can be healthy while still harboring different communiinstitute worked with a co-investigator at the University
ties of microbes,” said Jacques Ravel, PhD, associate
of Idaho to use advanced genomics and bioinformatics
professor of microbiology and immunology and associtechnology to gather information on the microbes in the
ate director of the institute. “Even microbes that were
samples and analyze the data.
previously believed to be detrimental to a woman’s
The researchers found five main groups of microbial
health seem to be part of a normal ecosystem in some
communities, and the proportion of women in each
women, according to this study. Further research is
community varied by ethnicity. They also found that
needed to establish the function of these microbes and
microbial communities that may not offer women optithe communities in which they appear. Some of the
mal protection were more common among Hispanic and
seemingly beneficial microbial communities seem to be
black women than they were in Asian and white women.
associated with a higher pH which is usually considered
to be unhealthy.”
“
”
[5]
news&advances
events
M
Davidge Key Presented to MAA
Another precious Davidge Hall keepsake has come home. In May,
Joseph W. Cavallaro, ’55, presented the Medical Alumni Association
with an original key to the front door of Davidge Hall.
The brass key is seven inches long and once unhinged a large bolt
securing the two large wooden doors. The original lock, although no
longer in use, was remounted during the 1980s renovation project
under the direction of dean John M. Dennis, ’45.
“There obviously wasn’t a need for the key,” Cavallaro recalled.
“And it wasn’t unusual back then for custodial staff to simply discard
old keys; so I asked for it and the janitor gladly obliged.”
Recognizing its historical significance, Cavallaro had the key
framed and displayed at his home in Frankford, WVa. He decided to
bring it along in spring for presentation to the MAA during his 55th
medical school reunion.
Joseph W. Cavallaro, ’55
events
Second Generation Davidge Elms
It’s been nearly a decade since the Davidge Elm was removed from
Lombard Street, but now a second generation is sprouting up throughout the state of Maryland.
The effort began in December 2001 when the tree was taken down
due to old age. Clippings were harvested and transported to a North
Carolina nursery where they were carefully nurtured by Bartlett Tree
Service. Last year they were deemed healthy for transplantation, and
alumni and friends were
invited to obtain their
piece of history with a
portion of the proceeds
benefitting Davidge
Hall restoration efforts.
The distribution began
in March when the
elms were transported
back to Baltimore. Four
were taken to Maryland’s eastern shore and
one was delivered to a
local country club; the
balance were planted at
private residences. An
English elm can grow as
tall as 95 feet.
Rick Taylor, ’75, and wife Kathie
beside their Davidge Elm
[6]
2010 CPC
If you missed the 2010
Historical CPC, it is now
available on DVD. To
order, mail an $18.00
check to:
522 W. Lombard St.
Baltimore, MD 21201-1636
or visit our website:
www.medicalalumni.org
2010
Simon Boliver ($18)
2008
Akhenaten ($18)
2009
John Paul Jones ($18)
Vatican Supporting Stem Cell Initiative
edical school researchers are leading
and epithelial cells. And they can be harvested easily
a new international research initiausing endoscopy. As a result, patients could have their
tive, funded in part by the Vatican,
own intestinal cells harvested and used to treat bowel
to explore the therapeutic potential
disease, reducing the risk of rejection or a reaction to
of intestinal stem cells. The Internathe transplant.
tional Intestinal Stem Cell Consor“We just want to take advantage of what nature is
tium includes scientists from Maryalready doing in the intestines,” Fasano concludes. “To
land’s center for stem cell biology
study this, though, takes multidisciplinary teams of
and regenerative medicine as well as
experts in stem cell research, experts in gastrointestinal
several institutes in Italy. The Vatican
medicine, experts in molecular biology and bioengineerand the Istituto Superiore di Sanita,
ing. We need all the pieces of the puzzle, and we need
the Italian equivalent to the National
to communicate freely, sharing our ideas and findings.
Institutes of Health, announced the
That is the intention of our consortium.”
partnership at a news conference in Rome.
The group is working to answer two critical ques“This new coalition brings together scientists from
tions: how intestinal stem cells can be kept alive and
both sides of the Atlantic to ensure we are exploring
made to replicate in the laboratory; and once healthy
every avenue of stem cell research in order to bring real
and flourishing, how they can be transformed into diftreatments as quickly as possible to patients
suffering from deadly conditions such as
Alzheimer’s disease and multiple sclerosis,”
says Alessio Fasano, MD, professor of pediatrics, medicine and physiology and director
of the mucosal biology research center and
the center for celiac research at the medical
school. “All of the partners have shown a
tremendous amount of energy and enthusiasm into putting this consortium together,
and we are thankful to the Vatican for making this research possible,” adds Fasano, who
is coordinating the consortium.
Prof. Garaci, director of the Istituto Superiore di Sanita, Prof. Bonanni, director of the Italian FDA, and
In addition to Maryland, the group
Alessio Fasano, MD
includes researchers from the Istituto Superiore di Sanita, the University of Salerno in
Fasano’s hometown, and the Bambin Gesúú in Rome,
ferent types of cells. If laboratory research goes well, the
the largest children’s hospital in Europe.
consortium could move forward with clinical research.
The ideal type of stem cells for medical use has
“I am confident that this partnership will facilitate
unlimited pluripotency—virtual blank slates that can
new discoveries about intestinal stem cells that will
become any kind of cell. Embryonic stem cells and the
lead to a better understanding of all types of stem cells,
newer induced pluripotent stem cells are prized for their
their function and potential to treat disease,” says Curt
pluripotency. Adult stem cells are not as pluripotent,
Civin, MD, professor of pediatrics, director of the cenbut harvesting them from a patient’s skin, muscle, bone
ter for stem cell biology and regenerative medicine, and
marrow—and now intestines—may be an important
associate dean for research at Maryland.
alternative, according to Fasano.
“Our center is dedicated to pursuing every promisIntestinal stem cells are highly active and support the
ing avenue of stem cell science using multidisciplinary
shedding and replacing of all the cells in the lining once
research partnerships between our faculty and the
every four to seven days. They are multipotent, already
construction of core facilities to support all types of stem
programmed to generate all the various kinds of cells
cell research. We hope this new funding will help us
necessary to line the intestine, including mucus cells
reach our goals.”
[7]
news&advances
Transitions
Hugh E. Mighty, ’82, associate professor and chairman of the department
of obstetrics, gynecology & reproductive sciences since 2000, was named vice
chancellor for clinical affairs at Louisiana State University Health Science Center
in Shreveport where he will also serve as professor of obstetrics and gynecology.
An expert in maternal medical disorders and critical care medicine, Mighty held
multiple leadership roles at Maryland including president of the medical staff and
chair of the women’s health collaborative. Christopher Harman, MD, is serving as interim chair of
the department, and a national search is underway
for Mighty’s replacement.
BOOKS
Stephen B. Liggett, MD, was named associate dean for interdisciplinary research. Liggett is
professor of medicine and physiology and is retaining the title of director of the cardiopulmonary genomics program. In his role as
associate dean, Liggett is fostering scientific collaboration between faculty members
from throughout the institution in order to develop a broad range of interdisciplinary basic science and translational research, which will both broaden institutional
basic research and lead to clinical applications for those basic science discoveries.
He thinks he’s just
slowing down with age.
Alignment
* * *
The Key to the Success of
The University of Maryland
Medical System
Co-authors Morton I.
Rapoport, ’60, former CEO
of UMMS, and Stephen
Schimpff, MD, former
CEO of UMMC, trace the
growth of University of
Maryland Hospital from
its birth as a private,
not-for-profit enterprise
in 1984 to a thriving, ninehospital system today.
$29.20 (with shipping)
To order on Amazon,
log on to:
http://www.amazon.com/Alignment-Success-University-Maryland-Medical/dp/0961911956/
What he doesn’t know is that shakiness and stiffness
are both early signs of Parkinson’s. He doesn’t know that
he’ll become a patient of the Parkinson’s Disease and
Movement Disorders Center, where an experienced team and
the latest medications will enable him to manage his
Neda H. Frayha, ’06, in
addition to recent appointments as assistant professor in
internal medicine and associate program director for the
internal medicine residency
program, is spending 50
percent of her time in the office of student affairs. Frayha
recently completed a year as
chief resident at Maryland.
In the office of student affairs
she replaces Gina Perez, MD.
symptoms for a number of years. And he doesn’t know that
when the time is right he’ll have Deep Brain Stimulation
surgery to significantly improve his quality of life.
w e h e a l . w e t e a c h . w e d i s c o v e r. w e c a r e .
*
Contributors to News & Advances include: Sharon Boston • Karen A. Buckelew • Ellen Beth Levitt • Larry Roberts • Bill Seiler • Karen Warmkessel Photos by: John Seebode • Mark Teske
[8 ]
u mm.edu / p a rki n so n s | 80 0 - 49 2 - 5 5 3 8
*
Discovery
By Jim Swyers, MA
Innovation
A snapshot of game-changing Maryland
research initiatives
Research funding at Maryland continues to surge, paving the way for
breakthrough discoveries and novel approaches to treating disease.
Writer Jim Swyers provides updates on four such initiatives currently
underway.
Unraveling Melanoma
M
Melanoma is the deadliest type of skin cancer, and the incidence of cutaneous melanoma
is increasing faster than any other common cancer, with an approximate doubling of rates
every 10 to 20 years in countries with Caucasian populations. Although melanoma is quite
curable in its early stages, once it has metastasized it is extremely difficult to treat.
“Thankfully, most cases of melanoma are caught in the early stages,” says Edward A.
Sausville, MD, PhD, professor of medicine and associate director for clinical research at
Maryland’s Marlene & Stewart Greenebaum Cancer Center. “However, if undiagnosed and
untreated, the tumor can spread downward into deeper skin layers and to lymph nodes and
internal organs. Once that happens, patients’ therapeutic options are very limited.”
People diagnosed with stage IV melanoma have an average life expectancy of only six
to nine months. However, this grim scenario may soon change for some advanced-stage
melanoma patients if a clinical trial led by Sausville proves promising. The trial is in a small
group of stage IV melanoma patients using a drug called pentamidine. It has previously been
approved by the FDA for treating certain types of parasitic infections.
Sausville’s main collaborator in the trial is David J. Weber, PhD, professor of biochemistry
and molecular biology. Weber’s laboratory previously discovered that pentamidine might be
effective against melanoma cells using structural biology techniques.
“A few years ago, my laboratory demonstrated that a calcium-binding protein known
as S100B, frequently found in high concentrations of melanoma cells, binds and inhibits
the function of a well-known tumor suppressor
protein, p53. We then hypothesized that if we
could interfere with S100B’s ability to bind to
p53, we might be able to restore p53’s normal
function and return melanoma cells to their
non-cancerous state,” explains Weber.
Armed with that knowledge as well as an
atomic resolution three-dimensional structure
of an S100B-p53 complex, Weber’s laboratory
began using nuclear magnetic resonance spectroscopy to screen already available chemicals
that might be able to disrupt the ability of
S100B to tightly bind to p53. After screening
a number of candidates, they came upon
pentamidine.
“Pentamadine was an extremely
exciting candidate,” explains Weber. “It
is often used to treat infections in AIDS
patients. Therefore, it has a demonstrated
safety profile. We didn’t want to use
something that was effective in blocking
the S100B-p53 interaction but was toxic
to patients.”
In subsequent studies, Weber’s laboratory demonstrated that pentamidine was
both highly effective in interfering with
S100B’s ability to bind to p53 in melanoma and was able
to restore the normal tumor suppression activities of p53.
He then contacted Sausville about collaborating on a grant
to test pentamidine in a clinical trial for patients with
advanced stage melanoma. The grant was funded by the
National Cancer Institute late last year.
Sausville and Weber are currently enrolling approximately 16 stage IV melanoma patients for a phase II clinical trial. The only caveat is that the treatment is not for
every patient who has melanoma. Patients enrolled in the
trial must have the p53 biotype—that is, they must have
S100B complexed with wild type p53. Although they are
reluctant to predict the outcome of the trial, they suggest it
has significant potential to be more effective than previously available therapies.
“Because we are selecting only those patients with a
very specific biotype, this is a very personalized approach
and is much more targeted therapy than any available to
date,” Sausville explains.
Above: David J. Weber, PhD, with Edward A. Sausville,
MD, PhD
At left: The two sites where the drug pentamidine interferes with S100B’s ability to bind to and inactivate the
tumor suppressor protein p53 in melanoma cells
Understanding
the Prion Theory
In 1982, UCSF researcher Stanley B. Prusiner published a paper in the journal Science
suggesting that a protein-only particle, or “prion” as he
dubbed it, could cause a neurodegenerative infection.
Specifically, Prusiner’s theory held that a normal, or
wild-type prion protein, which occurs naturally in all mammals as well as birds and fish, somehow becomes misfolded
and has the ability to convert other normal prion Proteins
into this misfolded structure and cause Transmissible
Spongiform Encephalopathies (TSE), a group of fatal diseases that, as they progress, riddle the brain with spongelike holes.
Even though Prusiner received the prestigious Nobel
Prize in 1997 for this work, the idea that a protein alone
could be an infectious agent remained a contentious issue
until just recently. Previously, only viruses and bacteria
were believed to have the ability to cause such an infection.
One of the most consistent skeptics of this prion theory
was Robert G. Rohwer PhD, associate professor of neurology at Maryland and director of the molecular neurovirology
Dr. Sausville can be contacted at [email protected] and Dr. Weber at [email protected]
[11]
protein, fold it into its infectious form, and show that it
would cause a TSE disease when inoculated into normal
animals. The interpretation of prior work had been confounded by the use of mutant prion proteins and abnormal
transgenic animals for assay,” Rohwer explains.
Over several years they tested numerous constructs
which resulted in long happy lives for the test animals.
Then 500 days after inoculation, hamsters inoculated
with one particular prion construct began to look “different” from the control animals. The experimental animals
displayed a repeated startle response, characteristic of neurodegenerative disease, and their brains were riddled with
amyloid plaques. Baskakov’s prion construct also produced
a prion disease in hamsters whose clinical course was in
some ways more similar to that in human
prion diseases than the prion diseases typically found in lab animals.
According to Rohwer, this experiment was convincing. “There was no
other explanation other than that the
synthetic misfolded prion protein was
causing the disease and that the protein
was both necessary and sufficient to
cause disease,” he says.
Although Baskakov is happy that the
prion theory has finally been exonerated, he is even more thrilled about the
(a)
(b)
prospects of using this technology and
the new animal model to answer various
Above: Robert G. Rohwer, PhD, and Ilia V. Baskakov, PhD
At right: Normal (a) versus misfolded (b) prion capable of causing neurodegenerative disease
questions about prion disease pathogenesis and, possibly, even intervene in its
course.
However, Rohwer is now a firm if still incredulous be“Now that we have an animal model,” Baskakov exliever. The person to change his mind was Ilia V. Baskakov,
plains, “we can address a number of quite puzzling issues,
PhD, who joined Maryland’s biotechnology institute in
such as the mechanism that these misfolded prions use
2001 from Prusiner’s laboratory. Baskakov, associate professor and head of the program in prion diseases at the institute, had developed a novel method of making abnormal
prions from wild-type ones.
Rohwer, who had spent 35 years searching for a viral cause for TSE diseases, attended a lecture given by
Baskakov and says he was “immediately impressed” by his
thoughtful approach to proving the prion hypothesis.
“I figured if anyone was going to succeed it was likely
to be him,” Rohwer says. “His laboratory was making
recombinant prion proteins in bacteria, isolating them,
to recruit normal prion proteins to their cause and which
and then utilizing various means to misfold them followed
parts of the brain are targeted by a particular strain of
by rigorous biophysical and biochemical characterizations
prion. We also hope to understand the structural features
of the resulting structures. However, he had no way to test
of prions that are important to infectivity. Furthermore,
them for infectivity. I convinced him to let me put his variin the long term, if we can understand the mechanism of
ous constructs into hamsters and see what happens. I also
action of prion propagation, it might be possible to design
won him over to the idea that to prove the prion theory to
interventions or even protective vaccines against these terskeptics like myself, he had to synthesize a wild-type prion
rible diseases,” he says.
In the long term, if we can understand the
mechanism of action of prion propagation,
it might be possible to design interventions or
even protective vaccines against these
terrible diseases.
Dr. Rohwer can be contacted at [email protected] and Dr. Baskakov at [email protected]
[12]
Orchestrating Stem Cell Research
S
“
Stem cells, which have the ability under certain conditions
to change, or differentiate, to any cell type, hold the promise of treating and even curing a myriad of debilitating and
life-threatening human diseases, such as diabetes, stroke,
and Parkinson’s disease. Until recently, however, progress
in bringing these potentially life-altering treatments to the
clinic has been hampered not only by funding shortages
but also because stem cell researchers worked in relative
isolation and advances have largely come in fits and starts.
All that is about to change and in a big way, thanks to
a $30 million, seven-year grant awarded recently by the
This is an extremely forward-thinking and
innovative project because it will allow these
high-quality stem cell research programs to
exchange information and ideas in real time
rather than waiting until any publish papers or
present data at conferences.
”
National Heart, Lung, and Blood Institute (NHLBI) to
Maryland to serve as the administrative coordinating center for a consortium of the nation’s most prominent stem
cell research centers. The idea of the consortium, known
as the NHLBI Progenitor Cell Biology Consortium, is to
bring together the best and brightest stem cell researchers
from around the country in cardiology, hematology, and
pulmonary medicine, to jump start and accelerate cutting
edge research in this exciting new field.
Michael L. Terrin, MD, CM, MPH, professor of epidemiology and preventive medicine, who was chosen to head
the coordinating center for the consortium, says that this
project has the potential to greatly accelerate the pace of
stem cell research and, more importantly, the development
of therapies based on stem cells.
“This is an extremely forward-thinking and innovative project because it will allow these high-quality stem
cell research programs to exchange information and ideas
in real time rather than waiting until any publish papers
or present data at conferences. Thus, it will establish an
extraordinarily robust level of communication and cooperation among these programs and ultimately accelerate
the development of stem cell therapies in this country and
elsewhere,” he explains.
A majority of the $30 million grant ($24 million) will
actually be distributed by the coordinating center to the
various consortium partners for pilot and collaborative
research projects. The remaining $6 million will allow the
coordinating center to provide capabilities for the consor-
Above: Michael L. Terrin, MD, CM, MPH
At right: A colony of human embryonic stem cells
(center). These cells are capable of differentiating
into any of the 220 types of cells in the human
body.
tium members to communicate by
voice, video conference and digital
media, as well as have access 24-7
to highly secure computer facilities to work on their projects together. At the heart of the
project is a website that will provide stem cell researchers
with tools they need to be successful, including immediate
access to databases, bioinformatics expertise, the ability to
share strategies and biological samples, and even tools for
publishing their results in scientific journals.
“From top to bottom, this project is about increasing
and expanding the level of communication and collaboration among stem cell researchers around the nation. This
one-stop website is designed to facilitate the ability of consortium members to communicate rapidly and easily among
themselves and the outside world, while still protecting the
security of their data,” says Terrin.
Additionally, the website will use peer pressure to
encourage collaboration among consortium members by
sharing “metrics” showing which programs are doing the
best job of collaborating and sharing information. This
peer pressure with be reinforced by NHLBI itself, which
may encourage consortium members who collaborate the
most productively by increasing their funding. In other
words, the more they collaborate the more funding they
will be eligible to put to good use. This incentive will also
spur individual programs to combine their data and start
research in new areas and in ways that would previously
have been impossible, explains Terrin.
Photo credit for stem cell image:
Clay Glennon, University of Wisconsin-Madison
laboratory at VA Medical Research Service in Baltimore.
“I never really believed the hypothesis that you could
have a huge spectrum of diseases that are caused by the
malformation of a single protein,” says Rohwer.
Dr. Terrin can be contacted at [email protected]
[13]
“Programs that may have found it convenient in the
past to keep their data to themselves will now find it more
beneficial to share,” says Terrin. “The result will be that
stem cell researchers will advance on parallel tracks rather
than sequentially as they have in the past. This is good for
everyone involved in the field, but especially for patients
who will benefit from the accelerated pace of therapeutic
development.”
Revolutionary Trauma Therapies
A
Approximately 1.4 million people sustain a traumatic brain
injury (TBI) each year in the United States, and at least
5.3 million have lifelong disabilities as a result of a TBI.
As many as 300,000 Americans currently are living with
a spinal cord injury (SCI). The cost of caring for these
individuals with TBI and SCI is in the hundreds of billions
of dollars each year.
When there is a significant injury to the brain or spinal
cord, a lesion occurs at the initial site of injury. Cells in
this lesion, often referred to as the “core” of the injury, undergo rapid loss of integrity and die. This sets off a cascade
of events that leads to even more damage in surrounding
tissue, resulting in a life-long, chronically degenerative
condition. Traditionally, it has been assumed little can be
done to reverse
either the shortterm or longerterm damage
caused by such
trauma.
“Recent studies that we and
others around
the world have
conducted suggest that there is
much more we
can do for these
patients,” says
Alan I. Faden,
Alan I. Faden, MD
MD, the David S. Brown Professor in Trauma and director
of the center for shock, trauma and anesthesiology research
(STAR) & National Study Center for Shock and EMS.
People who study TBIs and SCIs have typically assumed
there is nothing that could be done for the cells in the core
of an injury and have instead focused on ways to prevent
further damage to the cells immediately adjacent to the core.
“Our studies have determined that there is a type of programmed cell death, or apoptosis, which occurs in the core
of a TBI or SCI within 24 to 72 hours of the initial injury,
says Faden, a neurologist. “This type of cell death is regulated by a factor called apoptosis-inducing factor. We have
utilized a drug strategy for stopping this process and, in
animal studies, we have been able to reduce the size of the
core of the lesion and produce a significant improvement
in outcome. Therefore, we believe we may be able to treat
or even prevent cell death in the lesion core of a brain or
spinal cord injury patient if we can intervene as late as 24
hours or more after the initial injury,” Faden explains.
In addition to intervening in the immediate aftermath
of a TBI or SCI, Faden and his collaborators are working
on ways to prevent the long-term sequence of events that
occur after such an injury. Recently they identified a cluster of genes involved in inflammation that is switched on,
or “upregulated,” and reach maximum activity within one
to two weeks after injury. These genes remain chronically
upregulated thereafter.
One gene in particular is highly upregulated and seems
to remain that way permanently after a TBI or SCI. Faden’s
laboratory has identified a novel drug strategy for inhibiting this gene. Furthermore, on animal studies, his group
has shown that the drug regimen can protect the animals
from the long-term consequences of such an injury long
after the trauma.
“We gave animals with a TBI the drug regimen one
month after their initial injury,” Faden continues. “One
month later, the lesions in the control group had continued to grow while the lesions in the treated animals had
stopped growing. Imaging studies also showed that white
matter was markedly degenerated in the control animals
compared to the treated animals. Additionally, the drugtreated animals were significantly better off in terms of
cognitive and motor abilities. So, we now believe it may be
possible to treat a patient with a TBI or SCI even months
after their initial injury and affect a significant improvement in their status by—at minimum—halting any further
growth of their lesion and further degeneration of their
brain or spinal cord,” he says.
With wars in Afghanistan and Iraq, Faden says the
incidence of TBIs and SCIs undoubtedly will increase in
the near future. “Hopefully we soon may have effective
treatments to offer limiting their long-term disabilities.”
An Extra Mile
for the Extra Edge
Epidemiology and Preventive Health
By Rita M. Rooney
Photos by Richard Lippenholz
Webster’s has short-changed
epidemiology by a long-shot. The
dictionary defines the science
as a branch of medicine dealing
with the incidence and prevalence of disease in large populations. Of course, that’s true as far
as it goes. A more finely tuned
definition, however, might be that
epidemiology is the engine that
drives advances in public health.
Dr. Faden can be contacted at [email protected]
[14]
Jay Magaziner, PhD, MSHyg
t Maryland, the department of epidemiology and public health is supported by a
58-member faculty directing education and
research in six divisions in which 12 degrees
are awarded in master, PhD and dual-degree
programs. A wide range of research initiatives earns $15 million in direct research
funding annually from the National
Institutes of Health (NIH), the Center
for Disease Control, Veteran’s Administration, the Agency for Health Care
Research Quality, and other funding
organizations.
“We have a dual MPH degree
program with every school on the
Baltimore campus,” reports chair, Jay
Magaziner, PhD, MSHyg. “Our goal is to
integrate public health within the professions, rather than
training in the abstract. In essence, that charges us with
developing a whole new model of public health training.”
The faculty responsible for this ambitious undertaking is
strengthened by diversity among their backgrounds, complexity of their research, and uniformity when it comes to
achievement. They represent epidemiologists, physicians,
biostatisticians, behavioral and social scientists. Their
students are doctors, lawyers, nurses, pharmacists, dentists,
and social workers. Not all started out to take on prevention or public health issues. Many made a deliberate switch
at some point, going that extra mile for the additional
edge that equips them to tackle the tough questions that
inevitably precede and follow every medical dilemma and
research discovery. For instance, beyond looking at bench
research and clinical trials that determine what causes
breast cancer and how to treat it, students in the department question why many women still get the disease, and
why some don’t get optimal treatment in spite of clinical
practice guidelines.
Professor Mary-Claire Roghmann MD, MS, went from
medical school to a residency in internal medicine to a
fellowship in infectious diseases and then a master’s degree
in epidemiology.
“What I really enjoyed during my training was taking
my course work in epidemiology while working on my first
clinical research project,” she says. “I think it’s the same for
many of our students.”
Roghmann heads an NIH sponsored clinical research
curriculum award. Called the K30 program, it parallels
her own experience in that it is a curriculum that teaches
health care professionals how to do clinical research.
Initially, the program was focused on physicians interested
in clinical and translational studies in academic settings.
Their students are doctors, lawyers, nurses,
pharmacists, dentists, and social workers. Not
all started out to take on prevention or public
health issues. Many made a deliberate switch at
some point, going that extra mile for the additional edge that equips them to tackle the tough
questions that inevitably precede and follow
every medical dilemma and research discovery.
While the core group remains MDs, the master’s program
has expanded to include students from the schools of
pharmacy, dentistry and nursing. It’s designed to apply to
any type of study the student chooses, as long as it employs
the research methods learned through the program. An upcoming K30 initiative is one that will train PhD scientists
in the translational process, with the intent that such understanding will encourage them to continue their research
through to the next stage, enabling their discoveries to
follow a seamless path toward improving human health.
Renee Royak-Schaler, PhD, MEd, associate professor
and director of the master of public health program, says
the program is an important one which received a five-year
accreditation from the Council on Education for Public
Health in July 2009.
“Recent attention to public health issues, a surge in
volunteerism in the U.S. and overseas, and employment
opportunities in the public health workforce have probably
all contributed to the increased interest in and application
to public health degree programs,” she says.
She adds that what sets the MPH program at UMB
apart from others is its granting of dual degrees across all
professional schools, including masters of public health
degrees in the schools of dentistry, law, medicine, nursing,
social work and pharmacy. Classrooms facilitate multidisciplinary learning among the students, which is identified
as a unique educational opportunity by those seeking the
MPH degree. Students leave with methodological skills in
one of two concentrations—epidemiology or community
and population health. A new concentration in global
health is under development.
Anthony Harris, MD, MPH, a professor who heads the
division of health care outcomes research, reports that
news accounts of hospital-related bloodstream infections
have popularized a once “non-chic” interest, and that
consequently, infections have become a priority concern
among the public as well as by those in public health.
“We have an NIH grant studying risk factors for
antibiotic-resistant bacteria among intensive care patients,” he says. “We’re trying to determine whether certain
antibiotics are causing resistance or emergence, or whether
[16]
by this student has opened up
new, more cost-effective ways
to screen for MRSA among a
specific group of patients, rather
than screening every hospital
patient.”
He explains that, with regard
to the antibiotic resistant gram
negative bacteria, it was once
felt that antibiotics were driving the emergence of MRSA
more than transmission by the
patient, and therefore, infection control wasn’t a paramount
concern.
“However, I think the body
of research we’ve done has raised
awareness of a complicated interplay between antibiotics and
patient-to-patient transmission,”
Harris says. “That’s a paradigm
shift in many ways.
Roghmann adds that clinical
and translational research allows
a student interested in vaccine
development to look first at
the animal and human studies,
then to the drug’s initial safety
evaluation and effectiveness.
After this, the research becomes
an integral part of the practice
of implementation science, as
students get to see how clinical
and translational studies lead to
the practice of medicine—and
what needs to follow.
“It’s at this point that those
involved in the study of public
health begin to look for appropriate ways to implement evidence-based recommendations,” she says. “It may be through guidelines for clinical
Renee Royak-Schaler, PhD, MEd
the infection is due to a patient’s poor health, such as
comorbid conditions and severity of illness, or patient-topatient transmission via environmental factors within the
hospital.”
Another project that interests Harris’ group revolves
around an emerging bacterium, acinetobacter baumannii, a
global infection additionally seen among returning military
personnel. He says this project is funded by the NIH and
partially studied by medical students, and that early stages
of published findings are underway.
“One of our PhD students has been successful in working on a MRSA project, in which he made significant
progress in changing the conventional thought process
about the infection,” Harris says. “The work undertaken
“
Recent attention to public health issues, a
surge in volunteerism in the U.S. and overseas,
and employment opportunities in the public
health workforce have probably all contributed
to the increased interest in and application to
public health degree programs.
[17]
practice published by professional societies, or ultimately
through changes in public policy.”
A primary mission of the epidemiology department is
the provision of educational programs that prepare physicians and other health professionals to provide care based
on sound scientific evidence, specifically with regard to
Mary-Claire Roghmann, MD, MS
issues that have a big impact on patients’ lives. As the
first medical school in the country to teach preventive
medicine in 1833, Maryland has taken that objective and
directed it to activities embracing some of today’s major
health concerns. In every case, the classroom becomes a
laboratory for students who conduct studies as they learn.
Patricia Langenberg, PhD, professor, vice chair for academic programs, and director of the epidemiology doctoral
program, discusses an NIH career development award
which she directs. Targeting those interested in the field
of women’s health, the $500,000 yearly NIH grant supports four faculty scholars who devote 75 percent of their
efforts toward a research project. Recruited externally and
from among UMB faculty, they tackle a variety of women’s
health issues during their two-year or longer appointments.
Langenberg says issues have run the gamut from hormonal
influences on mood disorders to HPV and cervical cancer,
to effects of maternal diabetes on the embryo.
“These are important areas of concern,” she says. “It’s
amazing to me that, until recently, there had been little
research on the symptoms of menopause. We still don’t
know much about hot flashes and what causes them. But
that’s beginning to change.”
Langenberg points out that, until about 12 years ago,
most medical research operated on the theory that if existing knowledge about symptoms and vulnerability to certain
diseases worked for men, they worked for women as well.
She attributes the change to women in the U.S. Congress
who began to demand funding for research on gender issues.
The women’s health research group (WHRG), based in
the department but extending to a multidisciplinary consortium throughout the Baltimore campus, is examining
women’s health concerns from the perspectives of medicine, law, pharmacy, nursing, dentistry and social work.
Lauren Levy, who coordinates the WHRG, reports
that a series of symposia are directed to faculty members
throughout the campus, and that speakers address concerns
from career development to inconsistencies in research
affecting men and women.
“Our goal is to provide information about the ways in
which conventional research often has failed to consider
the differential impact of gender on outcomes,” she says.
“We hope such awareness will foster an environment in
which gender differences will become intrinsic to research
efforts.”
Department faculty also are engaged in training the
next generation of scholars in gerontology through the
gerontology doctoral program—one of only eight such programs in the country—which is funded by an NIH institutional training grant in the epidemiology of aging.
Gerontology doctoral program co-director, Denise
Orwig, PhD, points out, “The interdisciplinary nature of
the program provides a necessary foundation in preparing
students for serving the diverse older adult population,
which will increase over the coming decades.”
Commenting on the quality of the student body represented by the department, Royak-Schaler reports admission
criteria are heavily weighted.
“We look for students with credible reasons for seeking the degrees we offer,” she says. “We examine their
quantitative skills including grades and related experience.
Our access to all the professional schools on the Baltimore
campus enables the kind of multidisciplinary education
that attracts top students.”
“
We’re training researchers who will span
an entire health issue from bench to bedside
to community, and back again. They are the
ones who will evaluate research, who will
question whether a specific study has had an
impact on people, and whether we can say
we’re making a difference.
”
Her observations on the high education standards
within the department are reflected by Magaziner, who
agrees that a superior student body is critical to the department’s mission.
“We’re training researchers who will span an entire
health issue from bench to bedside to community, and back
again,” he says. “They are the ones who will evaluate research, who will question whether a specific study has had
an impact on people, and whether we can say we’re making
a difference.”
There is no question Magaziner himself has made a difference in the department he leads and in a larger perspective as well. His gerontology studies are highly regarded
throughout the country, and his work on hip fractures places him among the top authorities on the subject nationally.
One of his colleagues refers to the reputation he commands
at the NIH, saying that Magaziner is one of a few researchers the NIH has selected to receive two MERIT awards—a
personal distinction that provides support to key investigators whose productivity and excellence in research are
likely to continue in the future. The award is intended to
foster long-term expansion of a research program.
“Most of our gerontology studies target secondary and
tertiary prevention,” Magaziner says. “We’re interested in
the management of conditions after symptoms appear or
the patient first presents for treatment. The end goal is to
maximize how people recover from skeletal hip fractures
and other disabling conditions.”
Other gerontology research in the department includes
studies relative to new technology in the management of
diabetes, specifically evaluating the effectiveness of telehealth technology that monitors blood glucose levels, and
provides feedback on appropriate management to patients.
Scientists in the department also have authored a considerable amount of work on cognitive problems among older
adults, and new work on trauma and emergency medicine
in older persons.
Applauding the contributions of students, Magaziner
says research conducted by one former student determined
that the cause of death following hip fracture is substantially different in men and women. While men account for
only 25 percent of all hip fractures, death from infection is
substantially higher in men than in women.
Orwig, who is associate director of the Baltimore hip
studies program, explains the depth of the research and its
importance in targeting a critical health issue for men.
“The unique aspect of our current research is that we
are recruiting 200 men and 200 women for comparison
within a network of 25 hospitals in the area, giving us one
of the largest networks of recruitment sites in the world”
she says. “We already have shown some small differences
between men and women suffering hip fractures, and we
have reason to anticipate that the incidence of these fractures among men will increase significantly over the next
several years.”
She believes that, because men are living longer and experiencing osteoporosis in greater numbers, it is projected
that by 2040 they will suffer hip fractures as frequently as
women do today.
“Our research is exciting in that it is a fast-forwarding
focus on a significant health problem as its incidence
increases,” she says. “We are looking at a broad series of
assessments from physical functioning to cognitive issues,
and we’re following these patients for a year after their
fracture.”
One of the more unique courses in the department is
a tribute to the creativity and resourcefulness of a highly
innovative faculty. Langenberg explains that the required
course for MS and PhD students includes the participation
of five faculty members. Conducted through the graduate
program in life sciences, it is taught by department faculty
members who present a dataset and research questions that
have not yet been researched in that dataset. The concept
is that the student will have a publishable paper at the
conclusion of the course.
“This is a wonderful preparation for a student’s dissertation,” Langenberg says. “They start with a question,
they check the literature, refine it and create a hypothesis.
They question some more, make presentations to the class,
do complex analysis, do all that needs to be done before
writing a paper and presenting the results. Many wind up
publishing their paper.”
Magaziner believes that understanding of the value of
public health research and training is increasing and that
the future for epidemiology programs is favorable.
“The NIH is looking more and more as to how its
funding down through the years can be applied to larger
and more diverse groups of people,” he says. “What that
amounts to is a mindset that is concerned not only in developing studies focused on which interventions work, and
on strategies to deliver them to select groups of people—
but research that determines how well those interventions
affect the health of the public.”
Jay S. Magaziner, PhD, can be contacted at 410.706.3552 or [email protected]
[18]
[19]
f ac u l t y
news
Appointments to National Organizations
Toby Chai, MD, has been appointed to a
four-year term as a senior editorial consultant
for the American Board of Urology Examination Committee. He will be helping construct
the written exams that are given by the board.
Ziv Haskal, MD,
professor, departments of diagnostic
radiology & nuclear
medicine and surgery,
has been named
editor of The Journal
of Vascular and Interventional Radiology,
published by the SoZiv Haskal, MD
ciety of Interventional
Radiology. His five-year term begins in January
2011. The monthly, peer-reviewed scientific
journal—published since 1989—focuses
on the critical and cutting-edge medical,
minimally invasive, radiological, pathological
and socioeconomic issues of importance to
vascular and interventional radiologists.
Geoffrey Rosenthal, MD, professor,
department of pediatrics, who has been
a member of the
Food and Drug Administration Pediatric
Advisory Committee
(PAC) since July 2007,
is chair of the PAC
for a two-year term
ending June 30, 2011.
Geoffrey Rosenthal, MD
Recognized for his
fair and thoughtful perspective during committee deliberations and his expertise in many
sectors across the complex arena of pediatric
health, including cardiology, general medicine
and devices, Rosenthal’s appointment will be
critical as the committee extends its scope
beyond drugs to encompass biologics and
devices.
William Stanley,
PhD, professor,
William Stanley, PhD
department of
medicine, has been
appointed editor of
the American Journal
of Physiology: Heart
and Circulatory
Physiology (AJP). His
term begins January
of 2011 and runs through December 2016.
The AJP publishes original investigations on
the physiology of the heart, blood vessels,
and lymphatics, including experimental and
theoretical studies of cardiovascular function
at all levels of organization ranging from the
intact animal to the cellular, sub-cellular, and
molecular levels. The American Journal of
Physiology has been published since 1898,
and is one of the largest cardiovascular
research journals in the world.
Awards & Honors
Claire Fraser-Liggett, PhD, professor,
departments of medicine and microbiology & immunology
and director, institute
for genome sciences,
was inducted into
the 2010 Maryland
Women’s Hall of
Fame in March.
Fraser-Liggett was
Claire Fraser-Liggett, PhD
one of six women
selected for this
award, which recognizes Maryland women
who have made outstanding contributions
to the state and are visible models for future
female leaders.
David Jerrard, MD,
the first member of
this family, regulates
the assembly of
other proteins and
is important in the
movement of minerals and electrolytes
across cells, and the
function and signalEdward Weinman, MD
ing of a number of
hormones. Mutations
in the NHERF-1 gene have been identified in
patients with kidney stones and in estrogenreceptor-positive breast cancer and may also
be involved in psoriasis, schizophrenia and
some forms of deafness. The Middleton Award
is the highest honor awarded annually by the
Biomedical Laboratory Research and Development Service to Veterans Administration
biomedical research scientists in recognition
of outstanding scientific contributions and
achievements in the areas of biomedical and
bio-behavioral research relevant to the healthcare of veterans. It was established in 1960 to
honor Middleton, an educator and physicianscientist who served as the VA’s chief medical
director from 1955 to 1963. Recipients receive
a cash award of $5,000 and an inscribed
plaque, as well as $50,000 per year for 3 years
in additional research support. The award was
presented to Weinman in April by Undersecretary for Health, Dr. Robert A Petzel, at a
ceremony in Washington, DC.
associate professor,
and Joseph Martinez, ’98, assistant
professor, both from
the department of
emergency medicine,
were named “Top
Reviewers for 2009”
Joseph Martinez, ’98
by The Journal of
Emergency Medicine. Jerrard is editor of the
journal’s clinical laboratory section, while
Martinez edits the clinical reviews section.
Events, Lectures
& Workshops
Edward Weinman, MD, professor, depart-
all from the department of otorhinolaryngology—head &
Bryan Ambro, MD, MS
neck surgery, recently
returned from a surgical mission to Cambodia
that was sponsored by the American Academy
ment of medicine, is the 2010 recipient of
the William S. Middleton Award. Weinman and
his research associates isolated and cloned a
protein called the Sodium-Hydrogen Exchanger Regulatory Factor or NHERF. NHERF-1,
[20]
Bryan Ambro,
MD, MS, assistant
professor; Jeffrey
Wolf, MD, associate
professor, and Hernan Goldsztein,
MD, PGY-4 resident,
of Facial Plastic and
Reconstructive
Surgery Face to Face
International Humanitarian Program.
Ambro’s focus was to
surgically reconstruct
external ears of
children and adults
Jeffrey Wolf, MD
with congenital or
traumatic deformities. Wolf provided much-needed surgical
treatment of large head and neck tumors.
The doctors plan on making this an annual
mission, intended to help patients as well as
educate and train their Cambodian surgical
colleagues there.
Wilbur Chen, MD,
assistant professor, department of
medicine and center
for vaccine development, presented
“Overview of U.S.
Pandemic H1N1
Vaccine Development” at the Taiwan
Wilbur Chen, MD
Centers for Disease
Control, and “Hypersusceptibility to Lethal
Bacterial Pneumonia Post-Influenza Recovery” at the XII International Symposium on
Respiratory Virus Infections in Taipei, Taiwan,
in March.
Steven Czinn, MD,
professor and chair;
along with Maureen
Black, PhD, professor; Debra Counts,
MD, associate
professor; Virginia
Keane, MD, associate professor; and
Alessio Fasano.
MD, professor, all
from the department
of pediatrics, and
Yvette Rooks, MD,
assistant professor, department of
family & community
medicine, had the
opportunity to attend a special event
featuring First Lady
Michelle Obama
at the Newseum in
Washington, DC on
March 17. The First
Lady has begun a
nationwide campaign
called “Let’s Move,”
with the goal of solvAlessio Fasano. MD
ing the problem of
obesity among this
generation’s children. The event was sponsored by Newsweek magazine. Czinn spoke
with Claudia Kalb, senior writer for Newsweek,
who covers health and medicine. She is writing
stories about obesity-related outreach programs in various cities, and the two discussed
programs in our pediatrics department that
tackle this problem in Baltimore.
Claire Fraser-Liggett, PhD, professor,
departments of medicine and microbiology &
immunology and director, institute for genome
sciences, was invited to present “The human
gut microbiome and obesity in the Old Order
Amish,” at the 2010 MetaHit—International
Conference on Human Metagenomics in Shenzhen, China, in March. Also invited to speak
at the conference was Jacques Ravel, PhD,
associate professor, department of microbiology & immunology and institute for genome
sciences, who presented “The Temporal
Dynamics of the Human Vaginal Microbiota.”
Jennifer Russo Wortman, MS, assistant
professor, department of medicine, and associate director of bioinformatics, institute for
genome sciences, presented “A Data Analysis
and Coordination Center for the Human Microbiome Project,” at the conference.
Anthony Gaspari,
MD, the Albert Sha-
Steven Czinn, MD
piro, MD, professor
and chair, department of dermatology,
was featured on the
February 1 episode
of The Dr. Oz Show.
Gaspari discussed his
continuing treatment
of Dede, the Indonesian “tree man.”
Visiting Surgeon in Combat Care Program.
Her duties included providing surgical care for
wounded U.S. soldiers, Marines and airmen,
and teaching U.S. military medical personnel at Landstuhl Regional Medical Center in
Ramstein, Germany.
Julie Dunning
Hotopp, PhD,
assistant professor,
department of microbiology & immunology and institute for
genome sciences,
was invited to present “Gene Transfer
from Bacteria to
Julie Dunning Hotopp, PhD
Eukaryotes” at the
European Cooperation in Science and Technology Workshop on
Arthropod Symbiont Genomics and Metagenomics, held in January in Madeira, Portugal.
Thomas Scalea,
MD, Francis X. Kelly
Professor of Trauma
Surgery, department of surgery, and
director, program in
trauma, presented
“Damage Control
Orthopaedics: What
is it and Why is it imThomas Scalea, MD
portant?”; also “Difficult Case Management”; and “Where Does
Operative Control of Pelvic Fracture Bleeding
Fit In?” at the point counterpoint conference
in Doha, Qatar. Scalea also presented “Timing
of Fracture Fixation in Patients with Multiple
Trauma” at the trauma update entitled “Damage Control Strategy in Trauma,” in MilanoMalpensa, Italy.
Terez Shea-Donohue, PhD, professor,
Anthony Gaspari, MD
department of medicine, presented “Immune Regulation of
Intestinal Epithelial
Cell Function” at the
USA/Ireland Functional Foods Conference in Cork City,
Ireland in March.
Lisa Shulman,
MD, professor,
Sharon Henry, ’85, associate professor,
Maureen Black, PhD
department of surgery, participated in the
American College of Surgeons Distinguished
[21]
Terez Shea-Donohue, PhD
department of
f ac u l t y
news
neurology, was quoted in a March 31 New York
Times article on the phenomena of Parkinson’s
patients unable to walk because of their disease, yet are somehow able to ride a bicycle
with perfect coordination.
presented “Aspergillus Genome Database:
Comparative Genomics and Visualization
Tools,” at the 10th European Conference on
Fungal Genetics in The Netherlands, in March.
Scott Strome, MD,
professor and chair,
and David Eisenman, MD, associate
professor and vicechairman, department of otorhinolaryngology—head
& neck surgery were
invited lecturers at
Scott Strome, MD
the annual meeting
of the Israeli Society
of Otolaryngology—
Head & Neck Surgery
in Eilat, Israel. Strome
presented “Targeted
Monoclonal Antibody
Therapy for Head &
Neck Squamous Cell
Carcinoma: Current
David Eisenman, MD
Challenges and
Future Directions,”
while Eisenman spoke on “Pulsatile Tinnitus:
Evaluation and Management.”
Book/Textbook
Publications
Marc Hochberg,
MD, MPH, professor, department of
medicine, is lead editor of the textbook
Rheumatoid Arthritis
which received a
stellar review in the
November 4, 2009
issue of JAMA,
Marc Hochberg, MD,
MPH
302(17):1910-11. The
book was also awarded first prize under the category rheumatology
and orthopaedic textbooks published in 2009
by the British Medical
Journal.
John Kastor, MD,
Rodney Taylor
MD, MSPH, FACS
and Jeffrey Wolf,
MD, both associate
professors, department of otorhinolaryngology—Head
& Neck Surgery,
were invited to
lecture at the Ben
Rodney Taylor MD,
Gurion UniverMSPH, FACS
sity of the Negev,
Beersheva, Israel, on “Surgical Management
of Obstructive Sleep
Apnea.”
Jennifer Russo
Wortman, MS,
Jennifer Russo Wortman,
MS
assistant professor,
department of medicine, and associate
director of bioinformatics, institute for
genome sciences,
John Kastor, MD
professor and former
chairman, department of medicine,
published The
National Institutes of
Health. 1981–2008
(Oxford University
Press).
E. Albert Reece, MD, PhD, MBA, acting president of the University of Maryland,
Baltimore, and dean of the medical school,
co-authored with Robert L. Barbieri a textbook entitled Obstetrics and Gynecology: The
Essentials of Clinical Care, (Thieme Publishing
Group).
Grants & Contracts*
George Lewis, PhD, professor, institute of
human virology and department of microbiol-
[22]
ogy & immunology,
received a five-year
$2,955,849 grant
from NIAID for
his work entitled
“Broadly Neutralizing
Monoclonal Antibodies Against HIV-1.”
The goal is to identify
George Lewis, PhD
novel monoclonal antibodies that broadly
recognize the HIV-1 envelope glycoprotein
(Env) and block infection in vitro to guide vaccine development.
Mandeep Mehra,
MBBS and William
Stanley, PhD, both
professors, department of medicine,
received a two-year
$1.3 million award
from the National
Institutes of Health,
National Heart, Lung
Mandeep Mehra, MBBS
and Blood Institute
for a project entitled “Docosahexaenoic Acid
for Treatment of Heart Failure.”
Andrea Meredith,
PhD, assistant professor, department of
physiology, received a
five-year, $1,875,000
grant from the NIH
and Blood Institute to support her
research proposal
Andrea Meredith, PhD
entitled “Daily Regulation of Ionic Currents.”
Against Heat-Stable Enterotoxin of E. coli.”
The overall goal of this project is the development of a conjugate ST toxoid vaccine candidate against enterotoxigenic E. coli, the major
cause of traveler’s diarrhea and of bacterial
watery diarrhea among children in developing
countries.
Christopher
Plowe, MD, MPH,
professor, department of medicine
and center for vaccine development,
received a three-year
$1.5 million contract
from USAID for his
work entitled “MolecChristopher Plowe, MD,
MPH
ular Surveillance of
Drug Resistant Malaria in the Greater Mekong
Subregion.” The contract has a two-year
option period for an additional $1 million. Additionally, Plowe received a five-year $970,000
grant from the University of Oxford, funded by
Bill and Melinda Gates Foundation, to oversee
the Molecular Module of the Worldwide AntiMalarial Drug Resistance Network, whose
purpose is to develop and manage a global
database to validate new research tools for
efficacious use of anti-malarial drugs.
Jean-Pierre
Raufman MD,
Jean-Pierre Raufman MD
James Nataro MD/
PhD, ’87, MBA,
professor, department of pediatrics
and center for vaccine development,
received a two-year
$1,099,740 grant
through the enteric
vaccine initiative of
James Nataro MD/PhD,
’87, MBA
the Program for Appropriate Technology
in Health (PATH) entitled “A Toxoid Vaccine
professor, department of medicine,
received a five-year
T32 Training Grant
Competitive Renewal
in the amount of
$1,848,308 as
program director for
research training in
gastroenterology.
Aging R01 grant to study “Lateral Stability and
Falls in Aging.” This is the first R01 grant ever
awarded to the department.
Lisa Shulman, MD,
professor, department of neurology,
has been awarded a
four-year, $2,625,592
grant from NIH to
create a research
site for the PatientReported Outcomes
Measurement InforLisa Shulman, MD
mation System Project. The grant will be used to develop a new
measure of self-efficacy for self-management
of chronic disease and to perform validation
studies of this new measure in five chronic
neurologic disorders (epilepsy, multiple sclerosis, Parkinson’s disease, peripheral neuropathy, and stroke) at the University of Maryland
Neurology Ambulatory Center.
Hervé Tettelin,
PhD, associate
professor, department of microbiology
& immunology and
institute for genome
sciences, is the
principal investigator on a two-year,
$1,504,050 project
Hervé Tettelin, PhD
entitled “Comparative
Genomic Analyses of Streptococcus Pneumonia: Emergence of Multidrug Resistant and
Vaccine Replacement Serotypes.” Tettelin’s
project is part of the “Genome Sequencing
Centers for Infectious Diseases,” a major
federal contract under the overall direction of
Claire Fraser-Liggett, PhD.
Stefanie Vogel,
PhD, professor,
Mark Rogers, PT,
PhD, professor and
Mark Rogers, PT, PhD
acting chair, department of physical
therapy & rehabilitation science, has
been awarded a
two-year $1,156,662
National Institute on
department of microbiology & immunology, was awarded a
five-year, competing
renewal award totaling $3.7 million on
an NIH R37 grant en-
titled “Differentiative Signals for Macrophage
Activation.”
Owen White, PhD,
professor, department of epidemiology & preventive
medicine and
institute for genome
sciences (IGS) and
co-investigators
Jacques Ravel,
PhD, associate
Owen White, PhD
professor, department of microbiology & immunology,
Anup Mahurkar,
director of software
engineering, and
Samuel Angiuoli, bioinformatics
software manager,
received a three-year,
Jacques Ravel, PhD
ARRA, $1,894,381
grant for a project entitled, “MRI-R2: Acquisition of Data Intensive Academic Grid (DIAG).”
The DIAG project will serve as a resource for
investigators and will include a computational
infrastructure, a high-performance storage
network, and optimized data sets generated
by mining the data from public data repositories.
W. Gil Wier, PhD,
professor, department of physiology,
was been awarded a
four-year, $1,491,000
grant from the NIH
and Blood Institute.
The grant supports
his research proposal
W. Gil Wier, PhD
entitled “Physiological Regulation of MLCK in Intact Arteries.”
This study utilizes novel in vivo imaging of
transgenic mice to study mechanisms of
hypertension.
*Grants & Contracts of $1 million
and above
Stefanie Vogel, PhD
[23]
reunion
2010
2010–11
Medical Alumni Board
Otha Myles, ’98
President
Tamara Burgunder, ’00
President-Elect
Vice President
Victoria W. Smoot, ’80
Treasurer
George M. Boyer, ’83
Secretary
Protagoras Cutchis, ’83
Jerome Ross, ’60
Luette Semmes, ’84
Elizabeth Tso, ’79
Directors
Did we take your
picture?
Photographs from the
135th Medical Alumni
Reunion are available on
the MAA website: www.
medicalalumni.org. Please
visit our website to copy
your favorites.
Message from the MAA President
The 135th Recognition Luncheon
Practicing physicians remain on the cutting edge of scientific advancement by attending continuing medical education courses, reading publications, and attending grand
rounds and seminars. It is my pleasure to report that our
Medical Alumni Association is exploring another tool to
keep up-to-date: viewing medical school lectures through
the world-wide web. Whether it has been one year or 71
years since graduation, we believe alumni will appreciate
access to these classes taught by our world-class faculty.
Otha Myles, ’98
It is our hope to have as many as 50 lectures on line and
136th President
available to dues-paying members of the MAA by late 2010.
Most of these lectures were presented during the past year
to first- and second-year students in Taylor Lecture Hall of
the Bressler Research Laboratory. Many of them explore subjects involving advances in
understanding the human genome and other discoveries that have occurred since completing our medical school educations. Also included in the package for your enjoyment
will be historical pieces featuring the late Theodore E. Woodward, ’38, former chairman
of the department of medicine.
So, in addition to receiving four issues of the alumni Medicine Bulletin magazine and
enjoying a wide-range of services, your $85 membership will include this priceless offering. Once your dues are tendered, registration will take just a couple of minutes on our
website, www.medicalalumni.org.
It is an honor and a pleasure to serve as your president this year, representing more
than 7,500 living alumni of the University of Maryland School of Medicine. Please
join us in our work for this great medical school.
Elijah Saunders, ’60, Selvin Passen, ’60, and members of the golden anniversary class of 1960
were the guests of honor at the MAA Recognition Luncheon on April 30 at the Southern Management Corporation Campus Center. Saunders was recipient of the 2010 MAA Honor Award
& Gold Key, awarded for outstanding contributions to medicine and distinguished service to
mankind. Passen received the 2010 MAA Distinguished Service Award, presented for contributions to the medical school and alumni association. There were three additional honorees this
year: Allen R. Myers, ’60, Bernice Sigman, ’60, and Morton I. Rapoport, ’60. They received
the University of Maryland School of Medicine Alumni Leadership Award, presented to graduates who distinguish themselves in their chosen profession. Myers is the former dean at Temple
University; Sigman for 20 years served as associate dean for student affairs at Maryland; and
Rapoport was named CEO of the University of Maryland Medical System in 1982, a post he
held until retirement in 2003. During the luncheon, which also served as the annual business
meeting of the Medical Alumni Association, Otha Myles, ’98, was elected 136th president.
Otha Myles, ’98, completed an internal medicine residency and fellowship training in infectious
diseases at the Walter Reed Army Medical Center in Washington, D.C., He worked in the U.S.
Army as an infectious disease physician/investigator in the U.S. Military HIV Research Program/
Walter Reed Army Institute of Research until 2009. Myles recently returned to Maryland as
an assistant professor in the department of medicine. He has been serving on the alumni board
since 2003.
Our Medical Alumni Association
Mission: The Medical Alumni Association of the University of Maryland, Inc., in continuous operation since 1875, is an independent
charitable organization dedicated to supporting the University of Maryland School of Medicine and Davidge Hall.
Structure: The board consists of five officers and nine board members. Each year more than 100 alumni participate on its seven
standing committees and 13 reunion committees.
Membership: Annual dues are $85. Dues covering basic services are waived for emeritus members (graduated more than 50 years
or have reached 70 years of age). Recently graduated alumni in training pay $25. Revenues support salaries for two full-time and five
part-time employees, as well as general office expenses to maintain the alumni data base; produce the quarterly Medicine Bulletin
magazine; stage social events for alumni and students (including the annual Reunion); administer the revolving student loan funds;
and oversee conservation work on Davidge Hall and maintain its museum. These expenses are partially offset by the Passen Family
MAA Endowment Fund.
Counter-clockwise from top: Selvin Passen, ’60, recipient of the 2010 MAA
Distinguished Service Award; Elijah Saunders, ’60, receives the 2010 MAA
Honor Award & Gold key from MAA president Martin I. Passen, ’90; Some of
the more than 30 surviving members of the class of 1960 at the luncheon;
Sylvia Patterson, husband Ted, ’62, and Wendy Paul, ’95; SOM dean E.
Albert Reece, MD, MBA, PhD, with award recipients Allen R. Myers, ’60,
Bernice Sigman, ’60, and Morton I. Rapoport, ’60.
Annual Fund: The association administers the annual fund on behalf of the medical school. Gift revenues support student loans
and scholarships, lectureships, professorships, capital projects—including Davidge Hall conservation—and unrestricted support to
the dean.
[24]
[25]
reunion
2010
17th Historical Clinicopathological Conference
I
By Wayne Millan
Bolivar Died from Arsenic Poisoning
Paul G. Auwaerter, MD, MBA, FACP
It was arsenic and not tuberculosis that killed Simon Bolivar, one of South America’s
greatest military figures. This was the conclusion of Paul G. Auwaerter, MD, MBA,
FACP, clinical discussant at Maryland’s historical clinicopathological conference on
April 30.
Born in Caracas, Venezuela, in 1783, Bolivar died of a mysterious illness at age 47.
The common belief until now is that he died of consumption, a common condition
of the day, after suffering a long illness with a variety of symptoms. These included
frequent bouts of losing consciousness, skin darkening, weight loss, coughing, exhaustion, and persistent headaches.
In carefully reviewing the case, Auwaerter concluded that most of Bolivar’s symptoms point to a slow, chronic poisoning—the kind that results from drinking contaminated water.
“He spent a lot of time in Peru,” stated Auwaerter, associate professor and clinical
director in the division of infectious diseases at Johns Hopkins University School of
Medicine. “And there have been Columbian mummies found there that have tested
positive for high levels of arsenic.”
It is also believed that doctors were treating Bolivar with arsenic as a treatment for
some of his illnesses.
According to Auwaerter, there were no reports of Bolivar coughing up blood, and a green
fluid later found around his heart suggests a bacterial infection. There were also reports of a
tumor in his lungs that caused him to be severely hoarse. Auwaerter’s
conclusion: chronic arsenic intoxication complicated by bronchiectasis and lung cancer.
The diagnosis was embraced, at least in part, by Venezuelan
president Hugo Chavez. In a televised speech to his country after the
announcement of Auwaerter’s
findings, Chavez restated his
belief that it wasn’t tuberculosis that killed the general but
something more sinister: “I
don’t know if we’ll be able to
prove it, but I think they assassinated Bolivar,” he said.
Two representatives of the Venezuelan embassy
were dispatched to the event, including an individual serving on the presidential commission formally
investigating the death.
John Dove, MBBS, LRCP, FRCS, MSc, a retired
orthopaedic spine surgeon and Bolivar scholar from
Acharacle, Scotland, agreed that Bolivar had his
share of enemies and had avoided a few assassination attempts. Dove was invited to present a
historical perspective.
The conference serves as the centerpiece for the Medical Alumni
John Dove, MBBS, LRCP, FRCS, MSc
Association’s annual reunion.
Venezuelan president Hugo Chavez restated his belief that it wasn’t tuberculosis that
killed the general but something more sinister:
“I don’t know if we’ll be able to prove it, but
I think they assassinated Bolivar.”
[26]
Simon Bolivar: More of a Caesar than a Washington?
El Libertador:
his education, if rather casually; but he would always be an
enthusiastic reader. According to close associates in adult
life, whenever he could recline in his hammock he would
always have a book in his hands.
While in Spain, and only just turned 18, Bolivar met
and married an aristocratic woman a few years his senior,
Maria Teresa Rodriguez del Toro y Alaysa. They returned
together to Venezuela, but there she died (probably of yellow fever) within a year. Simon himself was not even age
20, and he vowed never to remarry. He kept the vow.
“Without the death of my wife, I would not have made
my second journey to Europe, and it is probable that the
ideas I acquired would not have taken root…the death of
my wife early propelled me on the road to politics,” he had
written.
He was said to be “desolate” at this time, but his eventual response was to cross the Atlantic once more and go
further with his education. He conducted a version of the
Grand Tour—again made possible by considerable inherited wealth. While visiting Italy in 1805, he showed his
developing ideology by swearing an oath to the ideals of
liberty within sight of the ancient Roman Forum. He then
visited the United States during the presidential term of
Thomas Jefferson and saw, as he later wrote, “for the first
time in my life…rational liberty at first hand.” But he did
not regard the Federal model of the U.S. Constitution
as practical in the society of Spanish America: his own
people would always need a strong military figure to lead
them. This was a principal to which, like his vow never to
remarry, he would definitely hold.
Spain was an illusory imperial power by the end of the
18th century, and after forces of Napoleon took control
over the Iberian peninsula in 1808, rebel leaders across
South America began to spark movements to free themselves. Initial success came to the “patriots” of Venezuela
by 1811, and the young Bolivar, now back at home, was
among their leaders. A royalist backlash ensued, however,
and eventually Bolivar fled to the Caribbean and spent
the better part of two years in exile—much of it in Haiti,
where he gained material support from freed slaves. After
his return to Venezuela in 1817, he would embark on a
decade-long series of struggles that resulted in the com-
The Liberator. He is still known that way today across his
native continent of South America two centuries after his
military and political career. One of the nation states that
he liberated from Spanish colonialism—Bolivia—bears
his surname, as does the currency of his home country,
The Bolivarian Republic of Venezuela. Heroic statues and
busts of him adorn cities in the United States, much of
Europe, and even some Asian capitals. Most often portrayed on horseback, Simon Bolivar is seen as the man who
will come riding to free the masses and grant them a form
of self-government. He is frequently compared to other
revolutionaries, military and political leaders who left
permanent marks: Napoleon, Alexander, and Washington.
His legacy endures in the nations of South America, whose
very existence as independent states depended on his peculiar strengths. Yet are such grand comparisons justified?
His full name was Simon Jose Antonio de la Santissima
Trinidad Bolivar Palacios y Blanco, and he was born in
July 1783, just months after the conclusion of the United
States’ war of independence. Bolivar’s family had been in
Venezuela since the 16th century and owned sugar and
cacao plantations, copper mines, and hundreds of slaves.
The Bolivars and their kin held high offices, and they
lived at the top of the Criollo elite, i.e., the ruling class
who were ethnically Spanish but born and raised in the
colonies of Spain’s vast American empire. Bolivar’s parents
died young; the future Liberator was an orphan before the
age of 10. Because his father had been among the richest
men in Caracas, however, the young Bolivar had extensive
opportunities for travel and education. His schooling was
along the lines of the pre-industrial era, when privileged
pupils arrived on their own time at small schools run by
tutors who were sometimes paid directly by their pupils. As
an adolescent he already showed a proud streak of independence. According to his older sister, Simon would “wander
the streets of Caracas, on foot and on horseback, associating with boys not of his own class.”
Bolivar spent time training with a local military unit
before departing for Europe at age 16. There he continued
[27]
To be fair, Bolivar faced a set of challenges that Washington did not: a society
larger, more diverse, and even more hidebound with traditional rules of class and
caste than was true in the 13 colonies of
British North America… Indeed, a
closer personal comparison may be to the life
and career of Julius Caesar.
reunion
2010
plete defeat of Spain. Not only did his home country gain
independence, but so too did Colombia, Ecuador, Peru, and
Bolivia, all due at least in part to Simon Bolivar’s skill and
determination.
Imbued with a strong sense of noblesse oblige—made
easier perhaps by the early death of his parents and his
own childless state—Bolivar viewed his personal ambition in light of service to every class of society. He was
clearly anti-slavery in a way that Jefferson was not, and
he offered freedom to any slaves who were willing to join
his army of liberation. Yet he was formally named dictator
of Peru in 1824 and attempted to create a presidency-forlife in Bolivia. He believed that the people around him
would continue to need a ruler with an iron hand. He was
in such a frame of mind that, in 1828, he was even able
to presume for himself the title of dictator over much of
the territory he had helped to free, known then as Gran
Colombia. At similar times in his career, George Washington had behaved very differently, giving up his command
of the Continental Army in 1783 (the year of Bolivar’s
birth), and later departing at his own volition the powerful
new presidency of the United States in 1797. Whatever
his personal motivations, Washington set an example of
temperance in the use of power that would never be easy
for future leaders to follow.
Bolivar, faced with internal dissent in the aftermath
of his extensive victories, tried to force himself onto the
new nations of South America and instead was ostracized.
Within a month of his declaration of dictatorial powers—
in September 1828—there was a conspiracy to assassinate
him. The conspirators may have included his own righthand man and vice president, Francisco Santander, and
without the intervention of Bolivar’s longtime mistress
Manuela Saenz they could well have succeeded. Soon
Bolivar had resigned all offices, left Venezuela for good, and
made plans to return to Europe. But his health increasingly
deteriorated, and he died at Santa Marta, Colombia, in
December 1830. He was just 47 years old, and, like George
Washington, he left no direct descendants.
To be fair, Bolivar faced a set of challenges that Washington did not: a society larger, more diverse, and even
more hide-bound with traditional rules of class and caste
than was true in the 13 colonies of British North America.
Bolivar’s world was closer to that of the ancient Mediterranean. Indeed, a closer personal comparison may be to the
life and career of Julius Caesar. Like Bolivar, Caesar was
a member of his nation’s elite who nonetheless identified
himself with a “popular” party. After some initial setbacks,
he achieved a decade-long series of military successes and
was eventually declared dictator (albeit a formal office
The Happening at the Harbor
The Baltimore Museum of Industry at the inner harbor
was the venue for Friday’s all-comers event on April 30
featuring jazz music and crab cakes.
with legal precedent in ancient Rome). Caesar then gained
some political successes, such as his reform of the calendar;
but the envy he engendered within the Roman elite was so
strong that he was the victim of a broad assassination plot
in March 44 BCE. It was probably the most famous, and
famously successful, plot in world history. Bolivar escaped a
similar plan of assassination but still lost power and indeed
did not live long after his narrow escape.
Caesar’s united Roman world would only be secured by
his great-nephew and heir, the man we know as the first
Roman emperor, Augustus. Bolivar had no such figure to
follow him, yet like Augustus, El Libertador would advertise
his achievements in grand but precise terms. As early as
the summer of 1813, after he had led patriot forces in the
retaking of Caracas from Spanish royalists, he declared to
the masses:
Your liberators have arrived, from the banks of the swollen
Magdalena to the flowering valleys of the Aragua and the precincts
of this great capital...victorious they have forded rivers...crossed
bleak and icy plateaus...they have triumphed seven times...they
have beaten five armies and 10,000 men.
Augustus, in a statement of achievement intended to be
a kind of political last will & testament, had written:
My fleet sailed through the ocean to a land which no Roman had
visited before...I pacified the sea and freed it of pirates...under my
auspices, two of our armies penetrated Ethiopia, and we defeated
an enemy force that had crossed the Danube...I gave eight gladiatorial games in which 10,000 men took part in combat...I celebrated
three triumphs.
Bolivar knew the language of power, but his plan of
political union proved to be fragile: it began to collapse
almost immediately after its founding. Not so the Roman
Empire, and not so the United States. Yet the Liberator’s
dream of free societies in South America, of Enlightenment liberty tempered by the need for strong leadership,
continues to show life into the 21st century.
Author Wayne Millan has been working behind the scenes of Maryland’s historical CPC for the past decade. A teacher and historian, he
has recently gone to work at the George Washington University as part
of their on-line teaching initiative.
[28]
C alls f or
2011 Awards Nominations!
Alumni, faculty, and friends are invited to send in their nominations for
two MAA-sponsored awards by November 1, 2010. The Honor Award &
Gold Key is presented to a living graduate for outstanding contributions
to medicine and distinguished service to mankind. Factors considered in
the selection process include impact of accomplishments, local, national,
and international recognition, supporting letters, and publications. The
Distinguished Service Award is presented for outstanding service to
the Medical Alumni Association and University of Maryland School
of Medicine. The awards will be presented during the annual Reunion
Recognition Luncheon on Friday, May 6, 2011. Letters of nomination for
both awards must include a curriculum vitae and should be addressed to:
Elizabeth Tso, ’79,
Chair, MAA Awards Committee
522 W. Lombard Street, Baltimore, MD 21201-1636
or emailed to: [email protected]
Honor Award & Gold Key & MAA Service Award
[29]
Clockwise: Jessica Campbell with husband Terence, ’80, and
son Earl, ’12; Joanne Saxour, ’00, with her party of six; C.
Ronald Koons, wife Shirlee, Maxine Morse, and Leonard
Morse, ’55; Candace Mainor, ’11 and Charelle Carter, ’11
reunion
2010
Reunion Class Parties
Class of 1975 at the Home of Rick & Kathie Taylor
Class of 1945 at the Maryland Club
Class of 1950 at the Hopkins Club
Class of 1990 at Tabrizi’s Restaurant
Class of 1960 at Tabrizi’s Restaurant
Class of 1995 at Turp’s Sport Bar
Did we take your picture?
Class of 1970 at the St. Paul Plaza Conference Center
Class of 1965 at the St. Paul Plaza Conference Center
[Reunion photographs can be downloaded on our website: www.medicalalumni.org by clicking “Photo Gallery.”]
[30]
Photographs from the 135th
Medical Alumni Reunion are
available on the MAA website:
www.medicalalumni.org. Please
visit our website to copy your
favorites.
Class of 2000 at the home of Tammy & Tripp Burgunder
[31]
By Rita M. Rooney
As an obstetrician, she worked with midwives and
became impressed by the results of the natural approaches they applied to childbirth. If all this makes
Pati seem a renegade physician, at odds with the medical profession, nothing could be further from the truth.
In fact, she credits her medical training at Maryland and
Georgetown for giving her the wherewithal to follow a
somewhat atypical approach to care.
“It is only because I have a solid foundation in
traditional medicine that I can be effective in what I am
doing today,” she says. “I have come to realize that there
is a continuum of interventions that allows restoration of good health—and they extend from increasing
oxygen and breathing to pharmacy, surgery, and beyond
to the interventions I have found useful. My experience
convinces me that the entire continuum has its place in
sound medical practice.”
Prior to establishing her practice, Pati spent a yearand-a-half researching hormone replacement therapy.
She prescribes hormones that are identical to the
human body including estrogen, progesterone, testosterone, thyroid, cortisol, and insulin. She saw five patients
during the first month the institute, then called the
Sajune Medical Center, opened. Six years later, that
number has increased to almost 50 patients daily.
A Singular Path
Alumna
Profile:
While that undergraduate exposure
to the National
Cancer Institute
played a role in
turning her sights
toward medicine,
so did the illness
she suffered as a
teenager.
Throughout her
undergraduate years, medical
school and life itself, Sangeeta
Pati, ’90, has exhibited the kind
of individualist thinking that
places her in the league of those
who march to the beat of their own drum. A cum laude graduate with honors from UM College Park in 1986, she graduated Alpha Omega Alpha from
the medical school and completed an OB/GYN residency at Georgetown
four years later. If her career path has taken turns some might call nonconformist, it is her educational pedigree that makes that course compatible
with that of more traditional colleagues.
As president and medical director of the Sajune Institute for Restorative
and Regenerative Medicine in Orlando, Pati heads a program that provides
integrative, evidence-based medical therapies combining conventional and
natural medicine to almost 7,000 patients a year.
Pati’s father was a physicist who traveled extensively and, as a result,
she attended school in Switzerland and a British boarding school in India,
where she mastered some of life’s important lessons—cooking, dancing and
singing. At 16, while in training for competitive sports, she was vaccinated
for cholera with a contaminated needle. As the result of a near fatal attack
of hepatic encephalitis, she was comatose for weeks, had numerous blood
transfusions, and was bedridden for six months. Following her recovery, she
returned to the U.S. and enrolled at College Park.
“I started out as a computer science major, and took a position at NASA
working on weather and the temperature satellite during my freshman year,”
Pati recalls. “It was a terrific opportunity for someone in computer science.
But it didn’t take long for me to realize that wasn’t for me.”
She promptly changed direction to electrical engineering. Soon after
that, she switched to the zoology honors program where she had the chance
to work at the National Institutes of Health a couple of days a week. It probably was at that point that she began to find herself in terms of her future.
“I had the chance to work in Michael Potter’s immunology laboratory at
the National Cancer Institute, she says. “I wound up spending time at Litton
Bionetics Research Laboratory in Rockville. It was an incredible opportunity, and undoubtedly set me on the road to a medical career.”
While that undergraduate exposure to the National Cancer Institute
played a role in turning her sights toward medicine; so did the illness she
suffered as a teenager.
“Because my condition was extremely grave, the medical staff didn’t want
to transfer me to a private hospital,” she says. “I was in a general ward in an
Indian hospital where I was surrounded by the poorest people who could not
afford care. This had a profound impact on me, and I kept coming back to it.
Sangeeta Pati, ’90
[32]
Although she has full privileges at a local hospital, she refers patients for surgery as needed, but
claims a 90 to 95 percent complete recovery as
a result of optimizing the body through a health
restorative program pioneered by her.
I wanted to help people.”
Her first experience following residency was at a
group practice in the Washington DC area. In a word,
she says it just wasn’t her concept of the way she wanted
to practice medicine.
“The other doctors in the practice weren’t happy
with the money I was bringing in,” she admits. “And
to be honest, I wasn’t all that happy either. Mine was a
more natural approach to pain control, for instance.”
She left that practice and accepted a position as
medical director for Engender Health, where she worked
with Columbia University under a $50 million Bill and
Melinda Gates Foundation grant to improve maternal
health worldwide. For several years, she spent as many
as 154 days a year in countries that included Kenya,
Tanzania, Nepal, India, Bangladesh, the Dominican
Republic, Thailand, Morocco, and Egypt.
“That was a turning point for me,” she says. “I realized during my time abroad that nothing I had learned
through my training prepared me to restore optimal
health to the body in a way that would allow the body
to cure itself. Medications don’t cure the underlying
intestinal and liver imbalances that cause cholesterol to
rise. This whole experience became an epiphany for me.
I was compelled to look beyond, to find other answers.”
Among the most common complaints she hears from
patients are fatigue, insomnia, weight gain, decreased
sex drive, anxiety, depression, and joint pain. She sees
patients suffering from osteoporosis, cognitive decline,
Alzheimer’s, cancer, stroke, and heart disease. She
says the institute uses medications when appropriate.
Although she has full privileges at a local hospital, she
refers patients for surgery as needed, but claims a 90 to
95 percent complete recovery as a result of optimizing
the body through a health restorative program pioneered by her.
As for life beyond her medical practice, Pati says it’s
a full one. She has a 19-year-old daughter and, when
time allows, she likes to paint, dance, laugh and play
with her dogs.
For additional information on Dr. Pati’s program, visit her
website at www.sajune.com
[33]
195 Years Ago
In 1815, a medical school library
opened on the first floor of the
medical building. It was created
after the medical faculty purchased
a collection owned by the late Dr.
John Crawford. He taught courses
on natural history, and his introductory lecture “The Cause, Seat,
and Cure of Diseases” correctly
predicted a relationship between insects and human illness. More than
500 volumes were acquired from
the Crawford family.
activities
A Salute to the Class of 2010
One hundred sixty-one graduates from the class of 2010 headed off to residency
training after graduation ceremonies on May 21. Ashley S. Huber Kinder
was recipient of both the faculty gold medal and Balder Scholarship Award for
outstanding academic achievement. The keynote address was delivered by Neal
Baer, MD, executive producer of the NBC television series Law & Order: Special
Victims Unit and formerly executive producer of NBC’s ER. This year’s graduating
class, 63 percent female, is training at 72 different hospitals in 27 states.
100 Years Ago
In 1910, James J. Richardson, Class
of 1889, became personal physician
to U.S. president William H. Taft.
Recognized as one of the leading
nose and throat specialists in the
country, Richardson served in this
same capacity for presidents Theodore Roosevelt and Warren Harding.
t William H. Taft
siden
Pre
25 Years Ago
In 1985, Morton M. Mower,
class of 1959, co-invented the
implantable automatic defibrillator. The device monitored and,
if necessary, corrected abnormal
heart rhythms. Mower was a
cardiologist at Baltimore’s Sinai
Hospital and began developing the device with Dr. Michel
Mirowski in 1969.
From left: Bonike Oloruntoba; Faculty Gold Medalist
Ashley S. Huber Kinder; Michael C. Grant, president
of the Class of 2010
A look back at America’s fifth oldest medical school and its illustrious alumni
[34 ]
[35]
a dv a n cement
JBDA
a dv a n cement
FY2010 New Members
Davidge Alliance Luncheon
Elm Society
The Medical Alumni Association and school welcomed 59 new members into
their society for major donors on April 29, bringing the total number to more
than 950 since its formation in 1978. The luncheon was held at the new Southern Management Corporation Campus Center. About 140 members were in
attendance for the event.
($10,000–$24,999)
Alumni
Timothy D. Baker, ’52
Robert J. Dawson, ’59
Allen R. Myers, ’60
Joel S. Mindel, ’64
John W. Maun, ’65
Larry A. Snyder, ’65
Richard M. Weisman, ’73
Charles P. Adamo, ’74
M.C. Kowalewski, ’75
Andrew P. Fridberg, ’78
Marianne N. Fridberg, ’78
Karen C. Carroll, ’79
Bruce C. Marshall, ’79
Peter J. Golueke, ’80, &
Valerie Golueke
Michael R. Kessler, ’80
George Thomas Grace, ’83
Mary T. Behrens, ’84
Robert C. Greenwell Jr., ’85
Merdad V. Parsey, ’89
Tuanh Tonnu, ’90
Kathryn M. Connor, ’93
David Chiu, ’98
Andrew C. Kramer, ’99
Faculty
Dr. Robert H. Christenson
Dr. Richard P. Dutton
Dr. Robert Liss
Dr. Chris Papadopoulos
Andrew Kramer, ’99, with father Morton, ’55, and Joseph S. McLaughlin, ’56
Friends
Dr. Lee Abramson
Dr. Akshay N. Amin
Mrs. Jean B. Clayton
Dr. Quintina Corteza
Mr. Jay Goozh
Dr. Nathan Levin
Mr. Michael E. Marino
Dr. Theodore T. Otani
Mr. Howard Saval
The Hon. Michael L. Subin
Mr. Robert Watt
Mr. Charles A. Wunder
Jean Clayton (second from left) with daughters Kay and Gina and son–in-law Jonathan
[36]
Cedric X. Yu, ScD, with Harry Knipp, ’76
Silver Circle
Friends
Mrs. Joan Dominique
Ms. Megan E. Hills
Drs. Dan & Nancy S. Longo
Dr. A. Harry Oleynick
Mr. Richard C. Smith
Mr. Karl Zheng
($25,000–$49,999)
Alumni
Henry D. Perry, ’51
Brian S.. Saunders, ’69
Thomas F. Krajewski, ’75
Robert E. Roby, ’75
Michael B. Stewart, ’75
Faculty
Dr. Frederic Huppe-Gourgues
W
MMMMMMMMMMMM
Rona and Larry Snyder, ’65
1807 Circle
($50,000 & Above)
John R. Rowell, ’67
Gordon I. Levin, ’68
Faculty
Dr. Cedric Yu
Friends
Dr. George C. Button
Mrs. Hilda Perl Goodwin
Dr. Cheriyath R. Nath
Mr. Gunther Wertheimer
Alumni
Allen J. O’Neill, ’45
Akshay N. Amin, MD, with wife Diane
Scholarships a Priority
What if any bright student could afford to live the dream of
becoming a doctor regardless of their financial situation because scholarships were available? Scholarships provide vital resources that help
keep the cost of a medical education affordable.
This year our graduating seniors head to training with $150,000 in
average indebtedness, and it is no secret that these obligations are also
impacting choices of medical specialty.
During the 2010 school year more than $1.2 million was available
at Maryland to deserving students through scholarships and awards.
Despite this, the school still lags behind peer institutions and unfortu-
nately loses some quality applicants to other institutions offering more
competitive financial packages.
The impact of scholarship support is far reaching. Since more than
half of the State of Maryland’s practicing physicians were either educated or training on our campus, we can help to ensure that the quality
of medical care in the state remains among the best anywhere. For
these reasons, raising money for scholarships is an important part of
the school’s fund raising campaign.
For more information on how you can help support our student
scholarship program, please contact the development office at
410-706-8503.
[37]
a dv a n cement
700 Attend Fund for Medicine Gala
New Waves in Medicine was the theme of the 2010 Fund for
Medicine Gala held by the medical school on March 27
at the Baltimore Marriott Waterfront Hotel. The annual
event was the largest yet in its six-year history with a crowd
topping 700, including a significant number of medical
alumni and university leaders. John and Tee Kelly served
as honorary co-chairs of the black-tie event, emceeing
the program that highlighted several excellent research
and clinical programs in the school. Kelly is president and
senior consultant at Kelly Benefit Strategies and a member
of the school’s board of visitors.
A video presented the theme featuring several faculty
members who described the new waves of discovery and
breakthroughs taking place at the school. The video can be
viewed on the school’s website http://medschool.umaryland.
edu. The program included a presentation about the dramatic, lifesaving work that faculty and medical center staff,
along with Catholic Relief Services, have been performing
in Haiti in the aftermath of the massive earthquake that
devastated the country earlier this year. Thomas Scalea,
MD, the Francis X. Kelly Chair in Trauma Surgery and
physician-in-chief of the R Adams Cowley Shock Trauma
Center, described the challenges his staff continue to
experience in Haiti. Musical entertainment was provided by
Mood Swings and lead Jack Vaeth ’92.
The gala raised more than $376,000, thanks to the participation of many generous corporate sponsors. The Whiting-Turner Contracting Company served as the presenting
sponsor for the 2010 gala. Platinum Sponsors included PNC
Bank and University of Maryland
Medical System.
Gold sponsors were
Joseph Farda and
family and M&T
Bank. Silver sponsors included Baker
Hostetler, LLP; BD
Diagnostics; Mr. and
Mrs. Frank Carlucci;
Comcast Corporation; Kelly Benefit
Strategies; Mercy
Medical Health
Martin I. Passen, ’90, and wife Amy
Services; Roche
Diagnostics, Inc., Skanska USA Building and University
Physicians, Inc. Bronze sponsors were the Association of
American Medical Colleges; Bevel Design; Dynasplint
Systems, Inc.; Illumina, Inc.; Lockheed Martin Corporation; University of Maryland Baltimore Foundation, Inc.;
University System of Maryland Foundation, Inc. and Webb
Mason. Gordon Feinblatt sponsored the entertainment and
Echo Communications was a Patron sponsor.
Next year’s Fund for Medicine Gala will be held on
Saturday, March 12, at the Baltimore Hilton Hotel, a short
walk from the University of Maryland campus.
Below: Michael Cryor, chairman of the SOM Board of Visitors, welcomes guests to the Fund
for Medicine Gala.
[38]
Managing
C
wealth
Protect Your Assets
ertain wealthy individuals, such as physicians, directors, business owners and other professionals are
more likely than others to have their personal assets
attacked by creditors. Popular asset protection tools,
including offshore trusts, limited liability business
structures and various asset titling techniques have
limitations and may involve risks. A domestic asset
protection trust (“APT”), when used in conjunction
with other techniques, may balance the risks and
protections offered and may therefore be the best
strategy to fulfill one’s asset protection objectives.
In 1997, Delaware enacted one of the first domestic
APT statutes (the Delaware Qualified Dispositions in
Trust Act) and since then, 10 other states have enacted
similar laws. Delaware has a long tradition as a leader in
personal trust law, and Delaware courts have proven their
competence and willingness to uphold the state’s law.
An APT permits an individual (commonly called the
Settlor) to create a trust, fund it with his or her assets,
and have the ability to receive distributions from the
trust, while the assets in the trust are protected from the
individual’s future creditors. The Settlor does not have to
be a Delaware resident; an increasing number of individuals from all over the U.S. and beyond create Delaware
APTs. To enjoy the creditor protection offered by a
Delaware APT, the trust must be irrevocable and it must
be administered under Delaware law. The trust instrument has to contain a spendthrift clause, which provides
that the interest of the beneficiaries of the trust may not
be transferred, assigned, pledged or mortgaged, whether
voluntarily or involuntarily, before the trustee actually
distributes trust property or income to the beneficiary.
The trustee of the trust must be either a Delaware resident or a bank or trust company authorized to conduct
trust business in Delaware.
Under Delaware law, the Settlor may retain the following rights to distributions from the trust: The ability
to receive income or principal distributions pursuant to
the trustee’s or an advisor’s broad discretion or a standard
as determined by the trustee and/or the advisors; the
annual right to receive current income distributions and/
or a specified percentage (5% or less) of the value of the
trust property; and as applicable an interest in a charitable remainder trust (“CRT”), a qualified annuity interest
in a grantor retained annuity trust (“GRAT”) or a grantor
retained unitrust (“GRUT”) and the use of real property
under a qualified
personal residence
trust (“QPRT”).
The Settlor may
name other beneficiaries of the trust as
well, including the
Settlor’s spouse and
children. Delaware
law also permits the
Settlor of an APT
to retain certain
additional rights, including a testamentary special power
of appointment, the
right to remove and
replace trustees or
This column is prepared by Ken Pittman, a senior
advisors, the right to vice president and wealth planner at PNC Wealth
Management. Ken provides fee-based wealth
consent to or direct
services, and he can be reached at
investments, and the planning
410-237-5324 or [email protected]
power to veto distributions. The trust instrument may also contain provisions
for the distribution of income or principal to the Settlor
to pay the taxes due on the trust income.
Physicians and other professionals may have personal
liability arising from malpractice claims to the extent that
the judgment exceeds available insurance coverage or if
the claim is not covered by insurance. Business owners
and corporate directors may be subject to personal liability for their actions or inactions. All wealthy individuals
are concerned about protecting their hard-earned assets
from judgments arising out of lawsuits, such as for personal injury or property damage caused by a car accident.
Still others may have a concern about protecting assets
from the claims of a future spouse in a divorce settlement,
particularly because of the limitations of prenuptial agreements. Delaware offers individuals a unique climate for
protecting and perpetuating wealth, and a Delaware
Asset Protection Trust may be an appropriate tool to
address these concerns.
The PNC Financial Services Group, Inc. (“PNC”) provides investment and wealth management, fiduciary services, FDIC-insured banking products and services and lending and borrowing
of funds through its subsidiary, PNC Bank, National Association, which is a Member FDIC,
and provides certain fiduciary and agency services through PNC Delaware Trust Company. PNC
does not provide legal, tax or accounting advice.
Investments Not FDIC Insured. No Bank or Federal Government Guarantee. May Lose Value.
© 2010 The PNC Financial Services Group, Inc. All rights reserved.
[39]
classnotes
1940s 1945:
Robert F. Byrne of
Wichita, Kans., reports that his
health has been good since retirement in
2001. He stays busy with his seven children
and 29 grandchildren and great grandchildren, reads medical journals and exercises
daily at the YMCA.
1950s
1954: Robert H. Ellis of
Fort Collins, Colo., continues to interpret electrocardiograms on a
daily schedule for a local hospital since
retirement in 1995. He also stays active
with garden maintenance, woodworking,
volunteering at a church and food bank,
and fund raising for the athletics department at Colorado State University. 1956:
C. Herschel King of Ashland, Ore., reports
that brother Daniel, ’55, of Sun City, Ariz.,
recently retired. v Mathew H.M. Lee of
New York City had his poem “My Pupukea”
published in Avocet, a quarterly journal
of nature poems. 1957: Charles R.
Oppegard and wife Juanita have lived in
the same Denver house for 47 years. He reports that gardening, politics, and learning
continue to occupy their time. For 25 years
Oppegard has been conducting disability
evaluations and is a volunteer in treating
the homeless. 1959: Joseph L. Darr of
Indian Wells, Calif., reports that after two
authorized breakins to his chest, he is still
able to recite the alphabet and tell funny
stories. He has had cardiac revascularization and a heart transplant. Darr extends
best wishes to classmates.
1960s 1960:
Merrill T. Syphus of
St. George, Utah, is performing body sculpting procedures at a medical
spa. 1963: Eric E. Lindstrom of Laurel,
Miss., continues practicing part time
and serves on the state medical association delegation to the AMA. Beginning in
November, Lindstrom begins his term as
president of the Southern Medical Association. 1965: Ann Robinson Wilke
reports that life is good in Advance, N.C.
1967: Boyd D. Myers of Annandale, Va.,
is spending more time at his second home
in Ft. Lauderdale, Fla., following recent volunteer work in South and Central America.
He looks forward to seeing everyone at the
50th reunion in 2017; until then he wishes
everyone well!
1970s 1970:
John P. Caulfield of
Los Altos, Calif., is consulting in research & development for biotech
and small pharmaceutical companies since
retiring from Hoffmann-La Roche in January. He enjoys the company of a grandson
More details are available at http://medschool.umaryland.edu/jpsychiatry/anniversary.asp
[40]
in Phoenix, a granddaughter in Italy, and
birding worldwide. v Walker L. Robinson
of Champaign, Ill., is a physician advisor at
the Carle Foundation Hospital after retiring
from there as head of neurological surgery
in December 2009. 1971: Daniel L.
Cohen of Alexandria, Va., is a senior partner for the international healthcare consulting firm Martin, Blanck and Associates,
with focus on patient safety and population
health management strategies. v Robert
E. Greenspan of Alexandria, Va., was
featured in the May 2010 Internal Medicine
News. The piece focused on his collection
of books and medical antiques. v Michael
J. Maloney of Cincinnati invites classmates
to read his blog NewPsychWithDrMike.Blogspot.com. v Robert J. Neborsky of Del Mar,
Calif., presented his model of attachment
based short-term dynamic psychotherapy
at the PPNOW Conference in London in
2009 and at St. John’s College at Oxford in
May. 1972: Robert J. Bauer of Hollywood, Md., has a grandson Alexander, born
to daughter Karen, ’02, and son-in-law David on March 3. Bauer and his daughter are
in practice together in southern Maryland.
v Brian J. Winter and wife Pat of Ellicott
City, Md., report that son Greg is receiving
additional training at the University of Pittsburgh School of Dental Medicine following
graduation from Maryland’s dental school
in spring. 1973: Nelson H. Goldberg of
Baltimore spoke at a volunteer appreciation celebration in Chestertown on April
20. Goldberg is professor of plastic surgery
at Maryland and a plastic surgery specialist
at Chester River Hospital Center. The event
ran in conjunction with National Volunteer
Week 2010. Goldberg also serves as vice
president of the Medical Alumni Association. 1976: Harry C. Knipp of Reisterstown, Md., reports that son David will be
attending medical school at Maryland in
fall, following graduation from the University of Pennsylvania summa cum laude. He
becomes the fifth straight generation of
Knipps to attend Maryland. 1977: Richard
Feldman of Lanham, Md., helped form
a new internal medicine practice group
along with available multi-specialty. 1979:
William O. Richards of Mobile, Ala., is
professor and chair of the department of
surgery at the University of South Alabama
College of Medicine. v Thomas B. Volatile
of Tyler, Tex., is an orthopaedic surgeon
at the Trinity Clinic, a 250-doctor multispecialty group.
1980s
1980: William J. Oktavec
of St. Augustine, Fla., enters
his 25th year of practice in the sunshine
state. He is director of the San Augustine
Eye Foundation. Oktavec and wife Kathryn
have four children living in Baltimore.
Daughter Kathleen is entering her fourth
year of medical school at Maryland, while
Billy, John, and Colleen are students at
Loyola University. 1981: Maura K.
Dollymore has been re-assigned to the
U.S. Coast Guard headquarters in Washington, DC. v Marc A. Jaffe of Barrington,
R.I., reports that son David graduated
from Maryland in spring as a member of
the class of 2010, while son Jonathan
begins in fall as a member of the class of
2014. v Stephen Ozanne of Cedar Hill,
Tex., is president of the Dallas County
Medical Society. 1982: Christopher M.
Aland of Newtown, Pa., reports that his
oldest child is an incoming freshman at
New York Medical School. 1984: Heidi
Gorsuch Rafferty and family recently
migrated to Penn Laird, Va., where she
serves as medical director of breast care
at the local hospital. Her children, ages 14,
11, and seven, are thriving after the initial
angst at yet another move. Rafferty reports
that they will stay put for the foreseeable
future. v Martin L. Schwartz of Irondale,
Ala., is a fellow in the American College of
Radiology. Schwartz is vice president and
musculoskeletal radiologist at Radiology Associates of Birmingham, clinical
professor of radiology at the University of
Alabama School of Medicine, and chairman
of radiology and musculoskeletal fellowship co-director at St. Vincent’s Hospital.
v Mitchell H. Weiss of Knoxville, Tenn.,
is chairman of the cardiology department
for 2010–2011 at Parkwest Medical Center.
He is privileged to work with cardiovascular surgeon Robert Helsel, ’69. 1985:
Charles S. Hames of Spring Valley, Calif.,
returned from an eight-month deployment
to Landstul Medical Center in Germany,
providing gastroenterology services to sick
and wounded U.S. soldiers evacuated from
Iraq and Afghanistan. Hames is a captain in
the U.S. Navy. v Steven Schoenfelder of
Lewisburg, Pa., is retired and was recently
hiking the Appalachian Trail. 1988: Jeffrey
P. Ross of Albuquerque, who specializes
in infectious disease, is president of the
Greater Albuquerque Medical Association.
He was in Tucson recently to compete in a
marathon. 1989: Tracy A. Berg has been
practicing vascular surgery in her home
town of Spokane Valley, Wash., for 15 years.
She reports that son Brian Magnuson is a
freshman in college.
What is LinkMD?
v
v
v
v
1990s 1991:
Marjorie K. Warden
of Woodstock, Md.,is a partner
in Physicians Eye Care Center. 1995:
Edward L. McDaniel of San Antonio
has deployed to Iraq for a second tour of
duty. 1996: Eric Carr of Owings Mills,
Md., delivered the keynote address at the
2010 pre-commencement ceremony for
the University of Maryland Department of
Medical and Research Technology. Carr is
an internist with Greater Baltimore Medical
Associates in Timonium. v Teresa Cox and
husband Alan are enjoying travel throughout Europe during Cox’s two-year assignment at the U.S. Naval Hospital in Naples,
Italy. She is in her 14th year of active duty
and was recently elected assistant chief
medical officer. v Mollie (Kelly) Kauffman
reports that she and husband Jonathan
live in Seattle with children Chuck, age
eight, Alice, age five, and two sub-standard
poodles. She works in family medicine
at the University of Washington. 1997:
Barbara Piasecki of Denver is a gastroenterologist, enjoying clinical practice and
all that the Rocky Mountains have to offer.
She recently saw classmate Carol Cox and
husband John, ’98, and family in Aspen
for some skiing and catching up. 1998:
Ryokei K. Imai and wife Cathy of La Palma,
Calif., continue to enjoy living in southern
California with children Brandon, age seven,
Ryan, age four, and Taryn, age one. 1999:
James L. Medina and wife Stacie of Lancaster, Pa., proudly announce the birth of
Aubrey Lauren, their third, on August 7.
[41]
v
v
v
Building a network among students,
residents, faculty, and alumni
Promoting a sense of solidarity and
pride within the University of Maryland
academic community
Enables students to bond, to discover
a mentor, and to prepare for professional life by bringing people together
in a relaxed, candid, personal atmosphere.
Interested doctors contact LinkMD
with a date, time, and venue at which
they would like to host an event, and
an electronic sign-up is posted on
MedScope, a website available to
Maryland medical students.
Hosting an event means providing
dinner at their house, at a restaurant,
meeting students for happy hour or
sharing a hobby (running, biking,
bowling, etc) with similarly interested
students.
While providing exposure to a specific
field of medicine, students are also
able to gain insight into the personalities that are drawn to different
specialties.
If you are interested in hosting an
event or learning more about LinkMD,
please email [email protected].
edu or visit http://web.me.com/linkmaryland.
2000s 2002:
Karen L. Bauer and
husband David Bowes of
Leonardtown, Md., announce the birth of
son Alexander Robert Bowes on March 3.
2003: Nathaniel Holzman and wife Joanna of Boston announce the birth of Drew
Lewis on February 25. Holzman is currently
serving a plastic surgery fellowship. 2004:
Kristina Suson, husband Boch, and son
Sage of Baltimore welcomed daughter Verity into the world on December 22, 2009.
in memoriam
in memoriam
Bernhardt J. Statman, ’37
Melvin Anchell, ’44
Pediatrics
Livingston, N.J.
January 2, 2010
Psychoanalysis & Family Medicine
Mission Viejo, Calif.
March 27, 2010
Dr. Statman trained at Newark City
Hospital. A captain in the U.S. Army
Reserves during World War II, his service
included caring for German POWs in Bavaria. He was discharged as a major and
resumed training in pediatrics before
setting up practice in Newark and West
Orange where he remained until retirement in 1996. Appointments included
director of pediatric ambulatory care at
St. Barnabas Medical Center in Livingston, consultant at Children’s Hospital,
and clinical associate professor of
pediatrics at the University of Medicine
& Dentistry of New Jersey at Newark. He
enjoyed music, history, and antiques.
Statman was preceded in death by wife
Sally.
Michael R. Ramundo, ’44
Surgery
Baltimore
May 25, 2010
After training in pathology at Baltimore
City Hospitals, Dr. Pines joined the
U.S. Army and was recruited into the
Manhattan Project. He witnessed the
first atomic bomb explosion during a
test at White Sands Missile Range in July
1945, and later was present during two
additional tests. Pines was discharged
as a captain and returned to Maryland
for surgical training at the Fort Howard
Veterans Administration Hospital. He set
up a private practice, enjoying privileges
at Sinai and South Baltimore General
hospitals as well as GBMC. He later
returned to the VA and retired in 1991
as chief of staff at Fort Howard. Pines
enjoyed reading, sailing, golf, tennis,
and travel. He also was a lecturer at the
Renaissance Institute and the Evergreen
Society, and he volunteered at Living
Classrooms Foundation where he taught
sailing. Survivors include wife Marion,
two sons, and three grandsons.
Dr. Ramundo served as a captain in the U.S.
Army during World War II after graduation,
interning at Paterson General Hospital and
receiving residency training at Franklin
Square Hospital, Jersey City Medical Center,
and at the VA in Fort Hamilton, New York.
During his career he maintained a private
thoracic cardiovascular practice in Clifton.
He was chief of thoracic surgery, director
of surgery, and senior attending in thoracic
surgery at St. Joseph’s Hospital in Paterson,
and he held similar appointments at The
General Hospital Center in Passaic where
he was also on the board of governors.
Ramundo was clinical associate professor of surgery, thoracic and cardiovascular
surgery at the University of Medicine and
BOOKS
Samuel R. Pines, ’43D
Surgery
Woodbine, N.J.
May 2, 2010
Dentistry of New Jersey. From 1973 to 1974,
he was president of the New Jersey Society
of Thoracic Surgeons. The Passaic County
Heart Association named Ramundo its
man of the year in 1980, and he received
distinguished service awards from St.
Joseph’s and the American Cancer Society
in 1982 and 1988, respectively. Ramundo
was preceded in death by wife Selma and
son Michael Jr., and he is survived by four
daughters and eight grandchildren.
Jerome Pleet, ’49
Obstetrics & Gynecology
Baltimore
June 7, 2010
Dr. Pleet served at Fort Campbell in
Kentucky during the Korean Conflict and
was discharged with the rank of captain.
In 1955, he established a private OB/GYN
practice which expanded to seven offices
throughout Baltimore. During his career,
Pleet delivered 15,000 babies and had privileges at Church Home, Lutheran, Franklin
Square, South Baltimore, and Baltimore
General hospitals. Pleet was a Baltimore
Advice to the
Young Physician
Written by Richard
Colgan, MD, Advice to the
Young Physician reveals
how to make the transition from technician to
healer as taught by some
of medicine’s greatest
teachers. Colgan is an associate professor at the
School of Medicine and
director of undergraduate
education in the department of family and community medicine.
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[42]
Orioles fan, enjoyed duckpin bowling, and
was a bridge life master who competed in
numerous bridge tournaments. He played
golf, followed thoroughbred racing, and was
a founding member of the Baltimore Glass
Club—an organization of antique glass
collectors. He is survived by wife Selma,
three children, 11 grandchildren, and six
great-grandchildren. Pleet was preceded in
death by daughter Shalom.
Bate C. Toms Jr. ’50
Surgery
Martinsville, Va.
June 4, 2010
Prior to medical school, Dr. Toms joined
the U.S. Navy in 1941 and served in both
the Atlantic and Pacific theaters. He was
discharged with the rank of lieutenant
commander. Union Memorial Hospital in
Baltimore was the location of his internship, followed by surgical training at Union,
where he was chief resident, and Maryland.
Toms moved to Martinsville, Va., in 1956,
becoming the city’s first board-certified
surgeon and member of the Virginia Surgical
Society. He enjoyed playing golf and growing orchids. Survivors include wife Margaret,
three sons, and five grandchildren.
Roy K. Skipton, ’51
Obstetrics & Gynecology
Cheverly, Md.
April 20, 2010
Prior to medical school, Dr. Skipton served
as a paratrooper in the 82nd Airborne
Division, 508 Parachute Infantry Regiment
of the U.S. Army—the famed Red Devils—
during World War II. As an infantry platoon
leader he received two Purple Hearts for
wounds suffered in Holland in September
1944 and the Battle of the Bulge in December of that same year. Upon graduation
from medical school, Skipton interned at
Maryland and also at Maryland General
Hospital where he received residency
training in OB/GYN. He practiced at Prince
George’s General Hospital until retirement
in 1984. Skipton was preceded in death
by daughter Susan and is survived by wife
Mary, one daughter, one son, five grandchildren, and three great-grandchildren.
William D. Rosson, ’52
Internal Medicine
New Carrollton, Md.
August 19, 2007
Dr. Rosson interned at Lutheran Hospital in
Baltimore and trained in internal medicine.
He operated a general practice from his
home beginning in 1962, and at the time of
his death he was seeing patients six days
a week. Rosson enjoyed painting and was
an excellent cook. He is survived by three
sons, one daughter, one stepson, and three
grandchildren. Marriages to Elaine Quarforth and Ella Seyfer ended in divorce.
James L. Banks, ’53
Family Medicine
Easley, S.C.
January 17, 2010
Memorial gifts are warmly received by:
Medical Alumni Association of the
University of Maryland, Inc.
522 West Lombard Street
Baltimore, Maryland, 21201-1636,
or for more information simply call
410.706.7454.
tory that provided blood analyses along
with toxicology screenings. Lancaster had
appointments on state and national committees including the College of American
Pathologists and the American Society of
Clinical Pathology. He enjoyed backpacking, gardening, cooking, and woodworking.
Lancaster was preceded in death by wife
Dolores and son Paul, and he is survived
by wife two sons, four daughters, and 13
grandchildren.
Robert G. Muth, ’56
William P. Houpt, ’54
Emergency Medicine
Bel Air, Md.
May 25, 2010
Baltimore’s Mercy Hospital was the site
of Dr. Houpt’s internship, before serving active duty as a medical officer in the
U.S. Air Force from 1955 to 1957. Houpt
returned to Baltimore and worked in private
practice from 1957 to 1961, and during the
next nine years was medical director for
Fisher Body & Chevrolet assembly plants.
He shifted his specialty to emergency medicine, working at Church Home & Hospital
from 1969 to 1975 and as an emergency
physician at Maryland General Hospital
from 1975 to 1985 where he was co-chief
of the department for two years. Survivors
include wife Mary Jane, four sons, and one
grandson.
Robert G. Lancaster, ’55
Pathology
Towson, Md.
April 24, 2010
Dr. Lancaster served in the U.S. Navy from
1958 to 1960. In 1961, he became laboratory director at Mercy Medical Center and
later became its department chair. He
served on Maryland’s faculty, and in the
1960s was one of the founders of the Central Laboratories of Associated Maryland
Pathologists. The group operated a labora-
[43]
Nephrology
Lutherville, Md.
January 29, 2010
Boston Naval Hospital was the location of
Dr. Muth’s internship, followed by residency
training at the National Naval Medical
Center and a nephrology fellowship at the
National Institutes of Health. In 1963, Muth
accepted a faculty appointment at the University of Missouri. He treated Harry S Truman shortly before the president’s death in
1972, and later Muth served a sabbatical in
Wurzburg, Germany. He retired in 1984. He
enjoyed travel and wildfowl carving. Survivors include wife Patricia and one son.
Robert B. Bokat, ’62
Pediatrics
Hilton Head, S.C.
March 23, 2010
Dr. Bokat interned with the United State
Public Health Service, spending time
on the Oglala Sioux Indian reservation
in Pine Ridge S.D., the Navajo reservation in Shiprock, N.M., and the Cherokee
reservation in Cherokee, N.C. A pediatrics
residency followed at the DartmouthHitchcock Medical Center in Hanover, N.H.
Bokat practiced pediatrics in Brunswick,
Maine, from 1968 to 1973 where he had
a teaching affiliation at Tufts University.
He practiced in Canton, N.Y., from 1973
to 1986, and in Hilton Head from 1986 to
2000. He enjoyed cooking, was an avid run-
in memoriam
ner and biker, built scale models of boats
and airplanes, and was a volunteer for the
SPCA. Survivors include wife Betty, three
daughters, and five grandchildren.
William E. Bruther, ’66
Ophthalmology
Annapolis, Md.
May 20, 2010
South Baltimore General Hospital was the
site of Dr. Bruther’s internship, followed
by residency training at Maryland. He was
a lieutenant commander in the U.S. Navy,
serving as an assistant medical officer
aboard the USS Shenandoah from 1965
to 1970. After his military commitment,
Bruther established a practice in Annapolis and from 1979 to 1981 was chief of
ophthalmology at Anne Arundel Medical
Center. Appointments also included associate examiner for the American Board of
Ophthalmology, member of the legislative leadership group for Medchi, board
member of CareFirst—Blue Cross and Blue
Shield of Maryland, and board member of
the Delmarva Foundation for Medical Care
Inc. Bruther enjoyed painting, hunting,
fishing, and he was a decoy carver who also
collected waterfowl and bird decoys. He
is survived by wife Sandra, one son, one
daughter, and four grandchildren.
R. Blair Garber, ’76
Family Medicine
Thomasville, Ga.
March 29, 2010
Dr. Garber received training at Tallahassee
Memorial Hospital. In 1988, he relocated to
Thomasville to serve as primary care physician and director of the Archbold Urgent
Care Center until retirement in 2002. He
enjoyed gardening and spending time with
family. Survivors include wife Laura and
three children.
Maureen C. Prendergast, ’82
Emergency Medicine
Millersville, Md.
March 14, 2010
Upon completion of training, Dr. Prendergast worked at a hospital in Three Rivers,
Michigan, and later as an emergency room
physician in Grand Rapids. She moved to
Salisbury, Maryland, in 1999 and worked at
Peninsula General Hospital for three years.
She also taught in the physician’s assistant
program at Anne Arundel Community College. Prendergast retired in 2002 due to failing health. She enjoyed reading and viewing
Hollywood movies from the 1930s, 1940s,
and 1950s. Survivors include one son and
one daughter.
who shot Gov. George Wallace during his
presidential campaign. From 1981 to 1983,
Brody served as president of the World
Federation of Mental Health and was its
secretary from 1983 to 1999. He retired in
1987. Brody enjoyed sailing and is survived
by one daughter and five grandchildren. He
was preceded in death by wife Marian and
two sons.
Rebecca E. Byrd, ’83
Geneticist/Administrator
Woodbine, Md.
March 24, 2010
Internal Medicine
Randallstown, Md.
April 8, 2010
Dr. Byrd is survived by one daughter.
Faculty
Eugene B. Brody, MD
Psychiatrist/Administrator
Baltimore
March 13, 2010
Dr. Brody joined Maryland in the late 1950s
and served as head of the department of
psychiatry for three decades on the faculty.
Born and raised in Columbia, Missouri,
Brody received a bachelor’s and master’s
degrees in experimental psychology from
the University of Missouri and his medical
degree from Harvard Medical School in
1944. He received training in psychiatry and
psychoanalysis at Yale University and the
New York Psychoanalytic Institute. Part of
his training was interrupted by World War II
when he became a captain in the U.S. Army
Medical Corps and headed the neuropsychiatric service for hospitals in the European Theater. Brody later became a consultant to the international military tribunal
conducting war-crime trials at Nuremberg.
He joined the faculty at Yale in 1948 where
he remained until moving to Baltimore in
1957. For the next 30 years Brody served as
professor of psychiatry, psychiatrist-in-chief
for Maryland’s hospital system, chairman of
the department of psychiatry, and director
of the institute of psychiatry and human
behavior. He was editor-in-chief of the
Journal of Nervous and Mental Disease and
was widely published. Brody testified for
the defense at the trial of Arthur H. Bremer
[44]
Albin O. Kuhn, PhD
Dr. Kuhn headed the University of Maryland Baltimore (UMB) campus from 1967
to 1980. Born and raised in Carroll and
Howard counties, Kuhn graduated from the
University of Maryland College Park in 1938
where he remained to earn a master’s degree in agronomy and botany. After military
service during World War II, Kuhn returned
to College Park to become chairman of
the department of agronomy and later assistant to the university president. In 1948,
he earned a doctorate in plant genetics
and physiology and performed additional
post-graduate training at the University of
Wisconsin. He was back in College Park in
1958 as executive vice president for the
University of Maryland and seven years later became vice president for the Baltimore
campus. His work in the early 1960s led to
the formation of the University of Maryland
Baltimore County (UMBC) which opened in
Catonsville in 1966. He headed both UMB
and UMBC until 1971, and continued exclusively as president of the UMB campus for
another nine years. During his tenure the
Baltimore campus expanded to 38 acres,
as the hospital doubled in size and modern
buildings were planned or erected for all
six professional schools. Kuhn returned to
College Park as executive vice president
and retired in 1982. He is survived by wife
Eileen, four sons, one daughter, 12 grandchildren, and 11 great-grandchildren. His
first wife Elizabeth died in 1986.

Summer 2010 - Medical Alumni Association

Transcription

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