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BCVS
Basic Cardiovascular Sciences
2012 Scientific Sessions: Frontiers in
Cardiovascular Science and Novel Therapy
Call for Abstracts and
Preliminary Program
July 23–26, 2012 I Hilton New Orleans Riverside I New Orleans, LA
Visit my.americanheart.org/bcvssessions
Sponsored by the American Heart Association’s Council on Basic Cardiovascular Sciences, Council on Clinical
Cardiology and Council on Functional Genomics and Translational Biology
Program at a Glance
Monday
July 23
7:00 AM
Tuesday
July 24
Wednesday
July 25
Thursday
July 26
Continental
Breakfast
Continental
Breakfast
Continental
Breakfast
Calcium and
Microsignaling
Domains in
the Heart
Clinical Trials
in Gene and
Cell Therapies
Refreshment Break
Refreshment Break
Refreshment Break
Mitochondrial
Biology
Tissue
Engineering
Molecular
Imaging and
Nanomedicine
Career
Development
Workshop/
Luncheon
Career
Development
Workshop/
Luncheon
Adjourn
7:45 AM
Molecular
Based Therapies
10:00 AM
Registration Opens
NOON
Exhibits Open
1:45 PM
Welcome and
Introduction
Myocardial Aging
Keynote Lecture
Refreshment Break
Outstanding Early
Career Award
Competition
Molecular
Signaling
Refreshment Break
Novel
Mechanisms
of Cardiac
Relaxation
Poster Sessions
Systems Approach
To Discovery
Mechanisms
of Cardiac
Remodeling:
Fibrosis and
Angiogenesis
Cellular
Reprogramming/
Induced
Pluripotent
Stem Cells
Keynote Lecture
7:30 PM
Oral Sessions
Refreshment Break
4:00 PM
6:00 PM
Legend
Poster Session
Poster Session
Poster Session
BCVS
Council Dinner
Become an AHA/ASA Professional Member and save
up to $300 off registration. (Promo code DBJ146ZZ)
my.americanheart.org/membership
Meals/Breaks
Important Dates
Jan. 10
Abstract and award
submission opens
March 14 Online registration opens
March 19 Abstract submission
deadline
March 23 Award application deadline
June 6
Last day to become an
AHA professional member
and qualify for a registration
discount of up to $300
(Promo code DBJ146ZZ)
June 20 Advance registration
deadline (on-site rates apply
after this date)
June 29 Hotel reservation deadline
(higher rates will apply
after this date)
Program Description
The primary sponsor of this premier research
conference is the American Heart Association
Scientific Council on Basic Cardiovascular
Sciences, the world’s leading organization of
cardiovascular scientists. The symposium,
titled “Frontiers in Cardiovascular Science
and Novel Therapy,” is designed to provide
state-of-the art coverage of the most exciting
scientific advances in cardiovascular medicine
and place these scientific insights in the
context of impact upon clinical medicine and
patient care.
The 2012 meeting brings together leading
scientists employing the most current
technologies for presentations ranging from
genomic technologies, molecular techniques,
stem cell science, and in vivo and proof of
concept studies in animal models and patients.
Over the past several years, there has been an
exponential growth in our understanding of the
molecular pathways that govern cardiovascular
physiology and disease, creating a translational
opportunity to move this knowledge into novel
therapeutic strategies. At the same time, there
have been major technological advances in
molecular imaging and nanomedicine that have
ushered in a new era of cardiovascular therapy.
The frontier of cardiovascular translational
science and medicine lies at the interface of
these parallel fields.
A diverse group of invited speakers from
within and outside the immediate field of
cardiovascular disease will present state-ofthe-art lectures on rapidly progressing areas of
wide interest, including genetics, non-coding
RNAs, proteomics, systems approaches
to biology, novel imaging modalities, tissue
regeneration, programmed cell death, and
subcellular compartmentalization of cell
signaling pathways, and will be presented
in the context of their relevance to the
pathophysiology of cardiac disease. The
meeting is structured to provide investigators
with diverse areas of expertise familiarity
with the novel conceptual approaches and
state-of-the-art technological applications
that are driving the most advanced biological
discovery. Accordingly, in addition to sessions
dealing with specific topics, such as ”miR
and Cardiovascular Therapeutics” and
“Myocyte Proliferation/Tissue Engineering,”
there are interdisciplinary sessions on leading
translational research applications covering
a broad array of topics. Additionally, this
year’s program features luncheon sessions
devoted to career development. This threeday conference is designed for a broad
audience of basic, translational and clinical
investigators, promoting interaction among
participants from diverse disciplines through
lectures, poster presentations, and informal
discussions. Special emphasis is placed upon
the inclusion of trainees and junior investigators
and the program features uniquely designed
mentorship sessions.
Register online at my.americanheart.org/bcvssessions
Program Committee
Yibin Wang, MD, Co-Chair
University of California, Los Angeles,
Los Angeles, CA
Roger Hajjar, MD, FAHA, Co-Chair
Mount Sinai School of Medicine, New York, NY
Annarosa Leri, MD, FAHA, Co-Chair
Brigham and Women’s Hospital, Boston, MA
Burns C Blaxall, PhD, FAHA
University of Rochester School of Medicine &
Dentistry, Rochester, NY
Asa B Gustafsson, PhD
University of California San Diego, La Jolla, CA
Joshua M Hare, MD, FAHA
University of Miami Miller School of Medicine,
Miami, FL
Lorrie A Kirshenbaum, PhD, FIACS,
FAHA, FISHR
University of Manitoba, Winnipeg, Canada
Walter J Koch, PhD, FAHA
Thomas Jefferson University, Philadelphia, PA
Michael Marber, MD, PhD, FAHA
King’s College London, London, UK
Kinya Otsu, MD, PhD, FAHA
Osaka University Graduate School of Medicine,
Suita, Japan
Who Should Attend
The program will be of special interest to
basic cardiovascular scientists, molecular/
cellular biologists, physiologists, translational
investigators, clinical trialists, practicing
cardiologists, cardiovascular nurses and
pharmacists. In addition, the symposium will
be of great value to scientists and executives of
pharmaceutical companies and biotechnology
firms who are in the cardiovascular space.
Continuing Medical Education
Continuing Medical Education
Accreditation — Physicians
The American Heart Association is accredited
by the Accreditation Council for Continuing
Medical Education (ACCME) to provide
continuing medical education for physicians.
Continuing Medical Education
Accreditation — Physician Assistants
AAPA accepts Category I credit from
AOACCME, Prescribed credit from AAFP,
and AMA PRA Category 1 Credit™ from
organizations accredited by ACCME.
Continuing Education
Accreditation — Pharmacists
The American Heart Association is
accredited by the Accreditation Council for
Pharmacy Education as a provider of continuing
pharmacy education.
Junichi Sadoshima, MD, PhD, FAHA
University of Medicine & Dentistry of New
Jersey, New Jersey Medical School,
Newark, NJ
Hiroyuki Tsutsui, MD, PhD
Hokkaido University Graduate School
of Medicine, Sapporo, Japan
Abstract Submission
Information
Rui-ping Xiao, MD, PhD
Peking University, Beijing, China
Interested investigators are invited to submit
abstracts for poster and oral presentation
beginning Tuesday, Jan. 10. Major media outlets
that reported on BCVS 2011 included WebMD,
US News & World Report, Yahoo!News,
Medical News Today, MedicineNet.com
and DailyLife.com. Their articles created
more than 424 million media impressions.
Wolfram Zimmermann, MD, FAHA
University Medical Center, Göttingen, Germany
Deadline: 5:00 PM CST, Monday, March 19
Become an AHA/ASA Professional Member and save
up to $300 off registration. (Promo code DBJ146ZZ)
my.americanheart.org/membership
Abstracts may be submitted in
these categories:
• Cardiac Regeneration, Stem Cells and
Tissue Engineering
• Cardiac Reprogramming and iPS Cells
• Cell Death Mechanisms, Apoptosis,
Necrosis and Autophagy
• Clinical/Translational Research
• Contractility and Calcium-Handling
• Genetics and Genomics of
Cardiovascular Disease
• Growth and Development
• Heart Failure Biology
• Hypertrophic Signaling Pathways
• Mechanisms of Cardiac Aging
• Mitochondria and Metabolism
• Myocardial Ischemia and Cardioprotection
• Myofilament Proteins
• Systems Approach to Cardiovascular Biology
• Transcriptional and Epigenetic Regulation
of Gene Expression
To submit your abstract, go to
my.americanheart.org/bcvssessions
beginning Tuesday, Jan. 10. Abstracts
accepted for presentation will be published
in the AHA journal Circulation Research.
Embargo Guidelines
Basic Cardiovascular Sciences Conference
abstract presentations are embargoed for
release at the date and time of presentation
or time of AHA news event. Information may
not be released before the scheduled
presentation time.
Conference Awards
Application deadline: Friday, March 23
Early Career Investigator Awards recognize
promising and outstanding investigators in
the early stages of their careers, stimulate
continued interest in basic or clinical research,
and help them participate in AHA/ASA
meetings. The Council on Basic Cardiovascular
Sciences proudly sponsors the awards listed
below and invites council members to apply. Detailed information about these awards
may be located on the conference website at
my.americanheart.org/bcvssessions.
New Investigator Travel Awards
New investigators who hold an academic
(or equivalent) rank below assistant professor
(postdocs and fellows) are encouraged to apply
for New Investigator Travel Awards. Travel
awards permit investigators to attend scientific
conferences where they can present their
research and engage in discussion with senior
investigators. Up to 20 competitive awards of
$500 each will be presented to qualified
new investigators from those who are accepted
to present abstracts.
Outstanding Early Career Investigator Awards
Up to three finalists will be selected based on
the originality, quality, and the impact of the work
presented in the abstracts, and the curriculum
vitaes. The finalists will present 10-minute oral
reviews of their abstracts during the conference.
The winner will receive $1500 and a one-year
subscription to Circulation Research; the
runners-up will receive $500 each and a oneyear subscription to Circulation Research.
Cardiovascular Outreach Awards
The awards encourage minority early career
investigators and students to participate in
the conference. Although preference will be
given to investigators and trainees with a
successful research abstract, a submission
is not required for consideration. Up to 10
competitive awards of $500 each will be
presented to qualified applicants.
Registration Information
Registration will open on Wednesday,
March 14. The conference registration site
may be accessed at my.americanheart.
org/bcvssessions. The deadline for advance
registration is June 20. After this date,
the registration fee will increase by $100.
AHA/ASA professional members pay
significantly discounted registration fees.
To qualify for the AHA membership rate,
you must join or renew by June 6, 2012.
Visit my.americanheart.org/membership,
(Promo code DBJ146ZZ). Affiliate with the
Council on Basic Cardiovascular Sciences,
responsible for the development of the
conference program content, or one of the
other 15 scientific councils.
Conference Venue/
Hotel Reservations
Experience the best the Crescent City has to
offer from the beautiful Hilton New Orleans
Riverside. Located on the banks of the
Mississippi, this full–service New Orleans French
Quarter hotel is adjacent to the Convention
Center, Riverwalk Marketplace and countless
French Quarter attractions and restaurants.
Enjoy the expansive health club and dine within
legendary restaurants. The AHA has arranged
reduced rates for conference attendees,
beginning at $139 per night. The rate will be
honored by the hotel July 20–29, based
on availability. Rooms will be available on a
first-come, first-served basis until all are filled
or until June 29. After this date, reservations
may be at the prevailing rate and will be subject
to availability. The guest room rate doesn’t
include applicable taxes. Guests booking with
the AHA group will have discounted access to
the hotel’s fitness facilities and complimentary
wireless access in their rooms. To take advantage of the reduced rates,
call (800) HILTONS (toll free) or (504) 561-0500,
or contact the Hilton by email [email protected] and ask for the
group rate for the American Heart Association
July 2012 conference, Group Code AHB.
The rates cannot be changed at check-in
or check-out for guests who don’t identify
their affiliation with the AHA when they make
their reservations.
Hilton New Orleans Riverside
Two Poydras Street
New Orleans, LA 70130
Phone: (504) 561-0500
Program Highlights
Keynote Lectures
• Eugene Braunwald, MD, FAHA, Brigham
and Women’s Hospital, Boston, MA
• Valentin Fuster, MD, PhD, FAHA, Mount Sinai
School of Medicine, New York, NY
Monday, July 23
Myocardial Aging
• The Role of Stem Cells in Cardiac Aging
• Overview of Cellular Senescence and
its Role in Tissue and Organ Aging
• Sirt1 Controls Stress Resistance and
Aging in the Heart
• Abstract presentation
Systems Approach to Discovery
• Systems Approach to Probe the Metabolic
Basis of Heart Failure
• Systems Genetics of Cardiovascular Diseases
• Zebrafish for Systems Studies of
Cardiovascular Biology and Diseases
• GMAS — Uncovering Novel Gene Modules for
Heart Diseases
• Computational Electrophysiology in Heart
• Abstract presentation
Tuesday, July 24
Molecular Based Therapies
• Interstitial Proteolytic Systems as Therapeutic
Targets in Cardiovascular Remodeling
• Biased GPCR Signaling: A Novel Concept
for Future Therapy of Heart Failure
• Isoform Specific bAR Signaling:
From Mechanism to Clinic Translation
• Neuregulin: A Case of Translation
• cGMP Modulators as Novel Targets
for Heart Failure
• Abstract presentation
Mitochondrial Biology
• An Omics Approach to Study
Mitochondrial Biology
• Mitochondria Metabolic Regulation
in Heart Failure
• Discover the Molecular Basis of
Mito-ca-Uniporter
• Identification of the Molecular Basis of
Mitochondria Ion Channels
• PTM of Mitoproteome in Injury and
Protection: Case Study
• Abstract presentation
Career Development Workshop
Molecular Signaling
• Signaling Pathway In Heart Disease
• Protein Nitrosylation in Cardiac Therapy
• PTM in the Cardiac Mitochondrial Proteome
in Heart Failure
• Protein Aggregation: A Culprit in Heart Failure
• Ubiquitination and UPS: Mechanism of
Heart Failure
• Abstract presentation
Mechanisms of Cardiac Remodeling:
Fibrosis and Angiogenesis
• Fibrosis in HCM
• Role of Angiogenesis in Stem Cell Therapy
• Angiogenesis
• Novel Innate Immune Modulators
of Cardiac Remodeling
• Cardiac Fibroblast Signaling and Fibrosis
• Abstract presentation
Wednesday, July 25
Molecular Imaging and Nanomedicine
Calcium and Microsignaling Domains
in the Heart
• Molecular Imaging of Cardiac Stem Cells
• Nanoparticulate Drug Delivery
• Imaging Metabolic Switch in Heart
• Nanoparticles and Vessel Homeostasis
• Abstract presentation
• STIM1 in Local Calcium Regulation:
A Critical Role in Cardiac Hypertrophy
• X-ROS Signaling in the Heart
• PLN Regulatory Partners: New Players in
SR Calcium Cycling
• TRPC 6-Calcium-Calcineurin Pathway
Controls Myofibroblast Formation and Fibrosis
• Local Calcium Signaling Through CaM
Kinase Signaling
• Abstract presentation
Tissue Engineering
• Cardiac Cell Sheet, Development and
Therapeutic Application
• Re-celluarization of Hearts
• Cardiac Microenvironment
• Engineered Heart Muscle from Stem Cells
• Three Dimensional Engineered
Cardiac Tissues
• Abstract presentation
Career Development Workshop
View my.americanheart.org/
bcvssessions for the most updated
program information.
Contact Information
If you have questions after reading this program,
contact the American Heart Association
National Center, Dallas, Texas:
Telephone
Fax
Email
Website
(888) 242-2453 (toll free)
(214) 570-5935
(214) 706-5255
[email protected]
my.americanheart.org/bcvssessions
Registration Information
Convention Data Services, Inc.
Outstanding Early Career
Award Competition
Telephone
• Featuring oral abstract presentations
from the award finalists.
Email
Novel Mechanisms of Cardiac Relaxation
• Titin In Regulation of Diastolic Function
• Cross-bridge Cycling and Cardiac Relaxation
• Heart Failure with Preserved Ejection Fraction
• Thin Filament Cardiomyopathies: an
Integrative Approach to a Complex Disorder
• Abstract presentation
Cellular Reprogramming/induced
Pluripotent Stem Cells
• iPS Cells Derived from Patients with
Long QT Syndrome
• Chemical and Functional Genomics
of Cardiomyocyte Differentiation from
Progenitor Cells
• Transcription Regulation of Cardiogenesis
• Abstract presentation
[email protected]
(General Inquires)
Lodging Information
Telephone
Email
Group
Code
Website
(800) HILTONS (toll free)
(504) 561-0500
[email protected]
AHB
NewOrleansRiversideHotel.com
Professional Membership
Customer Service
Lippincott Williams & Wilkins
Telephone
Email
Thursday, July 26
(866) 639-7214 (toll free)
(508) 743-8528
(800) 787-8984 (toll free)
(301) 223-2307
[email protected]
Clinical Trials in Gene and Cell Therapies
• Mixing Cells for Better Repair
• Use of Cardiac Stem Cells in Patients with
Ischemic Cardiomyopathy: The SCIPIO Trial
• Modified Cells for Therapy
• Stem Cell Based Therapy
• Clinical Trials in Stem Cells
Register online at my.americanheart.org/bvcssessions
©2011, American Heart Association 11/11DS4965
free of cardiovascular diseases and stroke.
to achieve our mission: building healthier lives,
energy, perspective and inspiration we need
that such diversity will enrich us with the talent,
reflect the world’s diverse population. We know
to ensuring that our workforce and volunteers
The American Heart Association is committed
sexual orientations, national origins and disabilities.
of all races, ethnicities, genders, religions, ages,
Cardiovascular diseases and stroke afflict people
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Join or renew your AHA/ASA Professional
Membership by June 6 and save up to $300
on registration. Promo Code DBJ146ZZ
Register today!
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BCVS