Patient Stratification - Biomax Informatics AG

PATIENT STRATIFICATION
TREAT THE INDIVIDUAL WITH THE KNOWLEDGE OF ALL
The Life Sciences Knowledge Management Company
www.biomax.com
Patient Stratification
Tailoring treatment of the individual using the knowledge of all
Patient stratification involves the use of biomarkers, genetic
profiles, research data and clinical information to create subsets
within a patient population allowing patients to be grouped in terms
of a therapeutic response.
Stratification reaches beyond current statistical patient evaluation
methods and epidemiological predictions to integrate and bring
thousands of clinical data points and intrinsic and extrinsic
parameters to the patient evaluation process. The result is better
decision making on behalf of the individual patient as well as the
healthcare delivery organization — a true win-win situation.
Biomax enables patient stratification by providing a computational
and conceptual infrastructure as well as solution building for the
integration and analysis of diverse data to elicit usable patient
knowledge. Benefits include the following:
Genetics
Biology
Biochemistry
Medicine
Lifestyle
Behavior
Sociology
Improvement of patient care and quality of life
Reduction of costs, unnecessary treatments and patient discomfort
etc.
Development of novel approaches to business management
and risk reduction
Biomax creates value for clients by eliminating software coding, reducing implementation time
and providing a means to bring critical insights to patient stratification.
The impact of being able to exploit clinical knowledge effectively
using state-of-the-art technology cannot be overestimated.
This applies to both improved patient care and better
management of treatment costs.
Prof. Wouters, Chairman Board of Directors, CIRO+
The Life Sciences Knowledge Management Company
Systems Medicine
Improving patient care by understanding
the intrinsic biology of disease
Systems medicine is the holistic approach to a patient’s care.
It incorporates evidence-based medicine with the interactions
between all components of health, disease, human genetics,
environment and behavior.
Prognosis
Prophylaxis
Diagnosis
Therapy
Not only does a systems approach improve therapeutic outcomes
for individual patients, it leads to significant reductions in both
healthcare delivery and clinical management costs.
By deciphering the functional and regulatory networks underlying
the behavior of complex biological systems and combining them
with clinical data, Biomax is helping organizations succeed
in bringing personalized medicine to their operations.
Most importantly, Biomax enables, in a few hours or days,
information to be extracted, fine-tuned and ultimately
realized as knowledge in the clinical environment.
Biomax has worked independently and in partnership with public and private organizations
for several years to develop computational and mathematical tools for disease-specific,
systems-wide approaches. Current project examples follow:
• SYNERGY — Modeling and simulation environment for systems medicine using
Chronic Obstructive Pulmonary Disease (COPD) as a use case
• AirPROM — Airway Disease PRedicting Outcomes through Patient-Specific Computational
Modeling
• MeDALL — Mechanisms of the Development of ALLergy
• SysCLAD — Systems prediction of Chronic Lung Allograph Dysfunction
• BIOBRIDGE — Integrative Genomics and Chronic Disease Phenotypes: Modeling and
Simulation Tools for Clinicians
• STATegra — User-driven development of statistical methods for experimental planning, data
gathering and integrative analysis of next-generation sequencing, proteomics and
metabolomics data
www.biomax.com
Biomax™ Health Informatics
Solutions for effective management of clinical knowledge
Biomax provides both conceptual and computational
infrastructure for an evidence-based and diseasecentric approach to healthcare delivery. Biomax
solutions are highly flexible and provide integrated
knowledge management using the versatile BioXM™
platform for patient stratification and targeted
therapy.
Biomax™ Health Informatics enables clinicians to
comprehensively evaluate clinical activity and use this
knowledge for better patient care, therapeutic and
business management decisions.
Biomax is enabling organizations to achieve the
following:
Profile patients against all previously
treated patients
Predict therapeutic outcome based on
holistic assessment
Deliver full transparency on any
clinical activity
Compare Biomax Health Informatics
Traditional Software Development
Adaptable Biomax Health Informatics
Recruit, interview and hire a team of developers
No new hires required
Write code
No need to write code
Long development time of months to years
Fully configurable by user within a few weeks or by
Biomax as a service
Inflexible to changing requirements and rapid
data growth
Evolving requirements built into the design (reconfigure
“on-the-fly”); unlimited scalability
Requires large project groups as domain experts
along with local IT expertise
Solution building process driven by lean teams or domain
experts; does not require local IT expertise
Results (hence success) become visible only at
the end of a (long) project
Fast turnaround times with first results becoming available
immediately
Download and configure life science data repositories
Life science data repositories included and pre-configured
Uncertain outcome
Proven technology and guaranteed outcome
Long-term maintenance costs may increase
significantly over the course of a project
Proven low maintenance cost over time and high ROI
The Life Sciences Knowledge Management Company
Biomax™ Health Informatics
Applying semantic integration to clinical data to achieve
patient stratification and personalized medicine
Case Study — Chronic Obstructive
Pulmonary Disease (COPD)
Objectives
Enable granular patient stratification scheme
Move away from standard therapeutic approaches
Improve individual patient therapy outcomes
Reduce costs and improve risk management
Clinical data
Methods
Using a customized Biomax solution, clinical data was
semantically integrated and transformed into practical
information and insights.Data consisted of 6,000
parameters per COPD patient, which was collected
on thousands of patients over six years.
Results
The resulting patient map confidently identifies
parameters for therapy outcome predictions.
A better understanding of the disease and effect
of treatment was established.
Biomax
Health Informatics
Transparency on patient care and resource
allocation was achieved.
Costs of patient care through more efficient
treatment and management were reduced.
COPD is a huge and growing burden for public health
worldwide… in Europe, an annual cost of
treatment of approximately 20 billion euros. The
CIRO+ Data Center allows for the first time a
better understanding of patient outcome based on
systematic pre- and post-assessment data of more
than 3,000 patients over the past 6 years with up to
6,000 clinical data points captured for each patient.
Therapeutic outcomes
Patient stratification
Prof. Wouters, Chairman Board of Directors, CIRO+
www.biomax.com
BioXM™ Knowledge Management
Ready-to-go software platform provides fast and flexible solution building
Biomax Health Informatics solutions are built using
the BioXM™ Knowledge Management
Environment. This ready-to-go software platform
transforms complex and diverse data into usable
information and knowledge by allowing
practitioners and business analysts to address
specific questions without cost-intensive and timeconsuming programming projects.
Flexible BioXM technology drives knowledge
management toward your specific needs such as:
Expand knowledge — semantically integrate
any data from any source seamlessly
Refine decision making — connect the dots
explaining biomedical systems
Create new hypotheses — visualize novel
relationships between data networks
Applications using the BioXM platform with virtually limitless possibilities:
Keep repositories of scientific data such as experimental results, a corporate gene index,
a phenotype catalog, a patient register or a compound database
Keep track of ongoing projects with one click to generate table reports and overview graphs
Generate networks from multiple sources in one step and find previously undetected links in the
data
Identify biomarker candidates based on automated literature analysis and compare the results to
experimental results in the same software platform
Connect clinical data and statistical analyses
Organize, review, compare, annotate and modify biological pathways originating from different
sources
Classify biological functions using ontologies specific to focused scientific areas
Easily integrate external statistical packages (R, BioConductor), bioinformatics tools,
chemoinformatic algorithms, Web services and more
The Life Sciences Knowledge Management Company
BioXM™ Knowledge Management
A graphical representation
Step 1: Design the data model
Step 3: Query and refine results
Step 2: Import
the specific information
Diverse data
Step 4: Deploy Web apps
to end users
See more details about each step
by visiting: www.biomax.com/agile
www.biomax.com
About Biomax
Biomax Informatics AG is a leading provider of customized
bioinformatics solutions. The company’s flagship product,
the BioXM Knowledge Management Environment, is
a powerful decision-support tool enabling measurable
productivity increases in biomedical R&D and clinical practice.
The easy-to-use and highly configurable software allows domain
experts, rather than programmers, to create, structure and
visualize complex scientific models. The product is supplemented
with sequence analysis, data integration, and text-mining software
modules and domain-specific biomedical content solutions, for
example in oncology.
Biomax creates value for clients by eliminating the coding
process, slashing the implementation time of complex projects,
and helping users to harness the information overload and distill
critical insights from data. The Biomax worldwide customer
community includes companies and research organizations that
are successful in the areas of drug discovery, diagnostics, fine
chemicals, food production and plant production.
Germany
USA
UK
Robert-Koch-Str. 2
82152 Planegg
T: +49 89 895574-0
F: +49 89 895574-825
1101 Highway 69, Suite 5
New Glarus, WI 53574
T: +1 608 636 2222
F: +1 608 636 0315
93 Boss House
2 Boss Street
London SE1 2PT
T: +44 7832 965 326
www.biomax.com
[email protected]
Biomax and BioXM are registered trademarks of Biomax Informatics AG in Germany and other countries. Viscovery is a registered trademark of Viscovery Software GmbH.
Registered names, trademarks, etc., used in this document, even when not specifically marked as such, are not to be considered unprotected by law.
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