2015 Annual Report - Institute for Women`s Health

Transcription

LONDON’S GLOBAL UNIVERSITY
UCL EGA
Institute for
Women’s
Health
2015 Annual Report
Our Vision
better lives for women and
babies across the world.
Our Mission
150th anniversary
celebrations
Elizabeth Garrett Anderson
To bring together the expertise of clinicians
2015 was the year of 150th anniversary since Elizabeth
and researchers from a diverse range
Garrett Anderson became the first woman to qualify as a
of disciplines so that they can deliver
doctor in Britain.
excellence and innovation in research,
Elizabeth Garrett Anderson was a pioneer of women’s
clinical practice, education and training
rights in medicine and society. Born in 1836, she made
in order to make a real and sustainable
history in 1865 by becoming the first woman to become
difference to women’s and babies’ health
locally, nationally and worldwide.
a doctor in the UK despite vigorous opposition from the
medical establishment. She was also Britain’s first woman
mayor and an early suffragette. She fought tirelessly for
We believe that things
could be better for women
and their families.
women to have access to high quality health care and
The objective of the Institute is to make
maternity and neonatal services moved to the new UCLH
a difference to the health of women,
babies and their families in the UK and
internationally by creation of a leading
centre of excellence for research, clinical
care, education and training.
From birth to puberty, motherhood to
menopause, maturity to old age, the
life course of women around the world
is filled with opportunities to improve
health and wellbeing.
The Institute team are dedicated to
making things better. We believe that
health care must be holistic. We aim
to improve knowledge, practice and
education in all aspects of women’s and
babies’ health.
for the right of women to practise medicine. In 1872, at
the age of 36, she founded the first British hospital for
women in London – which became the Elizabeth Garrett
Anderson Hospital after her death. In 2008 the hospital’s
Elizabeth Garrett Anderson Wing.
Contents
Our Mission
inside front cover
Contents1
Director’s Report
2
Athena SWAN at IfWH
3
People4
Current Structure
6
Education8
The UCLH Division of Women’s Health
12
Centre for Ethics in Women’s Health
14
Global Health
16
Research Department of Reproductive Health
19
Research Department of Maternal and Fetal Medicine
23
Research Department of Neonatology
27
Research Department of Women’s Cancer
31
External Appointments
35
Publications37
Facebook: www.facebook.com/ucl.ega.ifwh
Twitter: @ifwhUCL
Youtube: www.youtube.com/user/UCLIfWH
1 • 2015 Annual Report
UCL EGA Institute for Women’s Health
Director’s Report
Welcome to the
third annual
report from the
EGA Institute for
Women’s Health.
There are a number of issues to draw your attention to in
In September 2015 we celebrated the 150th anniversary of
this report, both academic and personal. Starting with the
Elizabeth Garrett Anderson becoming the first woman to
academic: after many anxious years of waiting, the results from
qualify as a doctor in Britain. The Elizabeth Garrett Anderson
UKCTOCS, the huge trial of ovarian cancer screening, reported
Hospital Charity together with UCLH Women’s Health
in the Lancet in December 2015. The results, as is often the
Division and the Institute co-ordinated a series of events to
case with large trials, are not entirely straightforward, but show
mark this important event.
promise that multimodal screening for ovarian cancer could
prevent women dying from ovarian cancer. Further follow-up
will be necessary to confirm or refute these initial findings.
Usha Menon, Ian Jacobs and the entire UKCTOCS team have
successfully delivered the largest individually randomised trial
ever done. This is a truly outstanding contribution to science.
Onto more personal issues, I am delighted to report that
Judith Stephenson received a Woman of Achievement award
for her outstanding contribution to health care from Women
in the City (page 19); Nikki Robertson gave a really excellent
inaugural lecture in May 2015, surrounded by family, friends
and colleagues; and congratulations to Marcia Jacks, Institute
Congratulations to Davor Jurkovic, consultant gynaecologist
Manager, who was awarded the Provost’s Excellence Award
at UCLH, who was awarded a large grant from the NIHR
in the Sir Stephen Wall equality award category for her long-
Health Services & Delivery Research programme to compare
standing commitment and proactive involvement in race
outcomes between different configurations of Early Pregnancy
equality at UCL.
Assessment Units (page 21). This ambitious programme of
work will hopefully report in 2018.
And finally, I will be leaving the Institute, and UCL, at the end
of June 2016 after more than five years as Institute Director.
Education is a strength of the Institute and I am delighted to
I have had a fantastic time at the Institute. It has been a
say that we will be starting an integrated BSc in Women’s
hugely rewarding role, which has challenged me on a daily
Health for the third year medical students in the autumn of
basis. The Institute has consolidated its position as the UK’s
2016. Melissa Whitten, Joyce Harper and many others have
leading centre for research and education across the breadth
made this possible (page 8). In future years we hope to be able
of Women’s Health, and it will continue to develop and grow
to accept students from outside UCL.
to achieve its mission to improve women’s health locally,
nationally and internationally. I want to pay tribute to all the
staff of the Institute for their dedication to this cause, and for
supporting me over the past five years. I will be starting my
new role as Director of the Birmingham Clinical Trials Unit at the
University of Birmingham in July.
Peter Brocklehurst
2015 Annual Report • 2
Athena SWAN at IfWH
At UCL EGA Institute for Women’s Health
the pursuit of gender equality underpins
The IfWH aims to:
our working culture and is fundamental
Promote science to all – women and men
to our research. We are committed to
Provide tailored support for the development needs of every
delivering the principles of the Athena SWAN Charter and to
actively foster the skills, talent and professional development of
women in science. We were awarded an Athena SWAN Silver
award in April 2013.
The Athena Scientific Women’s Academic Network (Athena
staff member – with a focus on key career transition points
Provide a supportive, flexible and family-friendly workplace
Always be open and transparent in our recruitment and
working practices
SWAN) Charter recognises commitment to advancing women’s
careers in science, technology, engineering, maths and
medicine employment in higher education.
The beliefs underpinning the Charter are: The advancement
of science, technology, engineering, maths and medicine is
fundamental to quality of life across the globe.
It is vitally important that women are adequately represented in
what has traditionally been, and is still, a male-dominated area.
Science cannot reach its full potential unless it can benefit from
Did you know?
In 2015 we have increased the proportion of female staff
in senior research positions
We have implemented open-to-all career advice
surgeries with senior staff, providing guidance on career
development
We have continued to promote flexible working,
the talents of the whole population, and until women and men
discussion of work-life balance and career development
can benefit equally from the opportunities it affords.
at appraisals, mentoring, transparency in promotion
opportunities and unbiased recruitment
In our recent staff survey, most staff members reported
that they were happy in their jobs and had sufficient
support and flexibility
The IfWH has signed up to the Race Equality Charter
Mark
We plan to go for an Athena SWAN Gold Award in 2016
For more information go to the Athena SWAN pages:
www.instituteforwomenshealth.ucl.ac.uk/aboutus/athena-swan
People
On the 31 December 2015 there were 93 staff employed by the
UCL EGA Institute for Women’s Health. In addition we had 96
honorary staff members, many who work at University College
London Hospitals NHS Foundation Trust. During 2015 we had 77
academic visitors to the Institute, hosted 38 postgraduate taught
students and 43 postgraduate research students.
11th IfWH Annual Conference, 14 July 2016
Current
Structure
UCLH Women’s Health Division
Women’s Health Division
Clinical Director
Donald Peebles
Divisional Manager
Amelia Godson
Breast
Jenny Gattuso
Gynaecology
Davor Jurkovic
Education
Joyce Harper
Postgraduate Studies
Eric Jauniaux
Sioban SenGupta
Graduate Research Advisor
Suzy Buckley
Undergraduate Studies
Melissa Whitten
Neonatology
Sara Watkin
Obstetrics
Ruwan Wimalasundera
Global Women’s Health
Gwyneth Lewis
Gynae Oncology
Nicola McDonald
May 2016
IfWH Director
Peter Brocklehurst
Institute Manager
Marcia Jacks
Professional
Services Staff
Reproductive Health
Judith Stephenson
Maternal and
Fetal Medicine
Anna David
Methodological
Support
Alexey Zaikin
Neonatology
Nikki Robertson
Women’s Cancer
Martin Widschwendter
Gynaecological
Development
and Function
Sarah Creighton
Perinatal Brain
Mariya Hristova
Preclinical Neonatal
Neuroprotection
Nikki Robertson
Gynaecological
Cancer Research
Centre
Usha Menon
Sexual and
Reproductive Health
Judith Stephenson
Maternal Medicine
David Williams
Neonatal Pain
Judith Meek
Translational
Research Centre
Reproductive Health
in Chronic Diseases
Ratna Chatterjee
Gene Transfer
Technology
Simon Waddington
Suzy Buckley
Neonatal
Neuroimaging
and Biomarkers
Nikki Robertson
Cancer Proteomics
Group
John Timms
Polycystic
Ovary Syndrome
Paul Hardiman
Prenatal Cell and
Gene Therapy
Anna David
Neonatal Seizures
Janet Rennie
Patient Care
Research Group
Anne Lanceley
Embryology, IVF
and Reproductive
Genetics
Joyce Harper
Preterm Labour
Donald Peebles
Neonatal
Clinical Trials
Neil Marlow
Preimplantation
Genetics
Sioban SenGupta
Cellular
Reprogramming and
Perinatal Therapy
Pascale Guillot
Neurodevelopmental
and Neurocognitive
Outcomes
Neil Marlow
Clinical Trials
in Pregnancy
Peter Brocklehurst
Education
The Institute for Women’s Health has a strong programme of teaching at both
undergraduate and graduate level and is a recognized centre for postgraduate clinical
training. Melissa Whitten is the Clinical Education Lead, Joyce Harper is the Director of
Education and Faculty Graduate Tutor (Taught), Sioban SenGupta is the Departmental
Graduate Tutor (Research) and Chair of the Board of Examiners, Eric Jauniaux is the
Departmental Graduate Tutor (Taught) and Helen O’Neill is the Teaching Fellow.
Undergraduate Education
Obstetrics, Gynaecology and Breast Surgery are part of the
core curriculum for all UCL 5th year medical students, and
development and delivery of the teaching programme is a key
part of the IfWH’s work. Clinical and academic staff lead in the
organisation, administration and delivery of the programme
on behalf of the Medical School, with students participating
in clinical activities across the three core teaching sites at
Bloomsbury, Archway and Royal Free campuses, as well as
at linked district general hospitals and community teaching
practices. The teaching faculty is drawn from across the clinical
and academic staff at the IfWH. Students are encouraged to get
involved with IfWH activities, and regularly stay involved once
In 2015, student surveys have put the Institute as one of the
they have moved into later clinical or postgraduate studies.
leading education providers in UCL. Our students are highly
The Institute has established a dedicated fund to support
satisfied as they have two very well organised programmes,
students to present work at external conferences, aiming to
outstanding education by leaders in the field (they are taught
encourage and support early career interest in Women’s Health.
by the scientists and clinicians whose papers they have read
In addition to the 5th
before coming to UCL), inspiring academic leadership, an
year UCL students,
outstanding careers programme and a unique network with
the IfWH supports
alumni. Our Graduate Administrator, Angela Poulter, received
the provision of short
a UCLU Student Choice Teaching Award in June 2015. The
term programmes of
education team was awarded a School of Life and Medical
teaching for 6th year
Sciences Education Award in recognition of their development
UCL students wishing
of a suite of Moodle pages for our MSc programmes, including
to undertake Student
an innovative welcome page for offer holders.
Selected Components
This year we also set up the Institute for Women’s Health
Education Fund. Donations will be used to sponsor students,
contribute to the purchase of educational equipment, and
assist in the provision of events for students and alumni
(www.instituteforwomenshealth.ucl.ac.uk/education/edu-funds).
in areas of Women’s
Health, and also hosts
external students from
all over the world who
wish to undertake
an elective period
in obstetrics and
gynaecology.
Recent developments in the core curriculum have included:
implementation of interactive clinical reasoning and casebased teaching sessions in conjunction with Pathological
Sciences
leading on the development of a Person-Centred Pathway
subspecialty training programmes (maternal and fetal medicine,
gynaecological oncology, urogynaecology), as well as rarely
available fellowship opportunities in Advanced Minimal Access
Surgery, Paediatric and Adolescent Gynaecology, Maternal
Medicine and Gynaecological Ultrasound. Junior doctors are
encouraged to be involved with the Institute’s academic and
where students engage with patients, including women
teaching activities. Short term observer and clinical attachment
booked for antenatal care and delivery at our linked Trusts,
opportunities are also available for junior doctors who are
to learn more about shared decision-making and supporting
interested in a career in obstetrics and gynaecology. Training
self-management for long-term health conditions
opportunities are also provided for junior doctors training in
implementation of a clinical leadership session in conjunction
genito-urinary medicine and sexual and reproductive health,
with the Clinical Skills Units to help develop leadership skills
in conjunction with colleagues at the Mortimer Market and
at an early stage of training
Margaret Pyke Centres.
In September 2016, we will be commencing our new Integrated
There is a wide range of regular teaching activities within the
BSc in Women’s Health for UCL 3rd year medical students. This
clinical unit, from perinatal and obstetric morbidity meetings to
is a really exciting development which will enable students
high-fidelity multiprofessional simulation training in obstetric
to learn about and get involved in many areas of practice
emergencies. UCLH, the Whittington and the Royal Free all
and research within Women’s Health, and which we hope will
regularly host regional teaching activities on behalf of the North
stimulate the interest and engagement of potential doctors and
East Thames Training Programme Management Committee.
researchers of the future!
The UCLH Fetal Medicine Unit has also developed a number
of nationally and internationally attended ultrasound training
Clinical Postgraduate Education
courses. UCLH is also one of the London centres which
Clinical postgraduate training and educational supervision
Emergencies and Trauma, and in advanced laparoscopic skills.
offers senior postgraduate courses in Managing Obstetric
in obstetrics and gynaecology is provided by IfWH clinical
staff and colleagues at UCLH, the Whittington and Royal
Free Hospitals. The junior doctor faculty is wide-ranging,
Postgraduate Education
incorporating Specialty Trainees at all levels of training,
Taught Master’s Programmes
Foundation Doctors, General Practice Vocational Trainees, and
Prenatal Genetics and Fetal Medicine, and Reproductive
senior clinical trainees in obstetrics and gynaecology who are
Science and Women’s Health Master’s Programmes
undertaking advanced programmes of training in specialist
and subspecialty areas of training. UCLH is one of only a
few UK centres to be able to offer the full range of RCOG
These programmes offer a comprehensive theoretical
understanding of these specialised topics, taught by clinical
and scientific research leaders in the field. The ethos of these
programmes is not just to teach the theory of each module,
but to teach the scientists to think like a clinician and
the clinicians to think like a scientist. A variety of key skills
are taught that give students a grounding that is essential
for their future careers, such as peer assessment, written
and oral communication skills, basic laboratory techniques,
how to referee a paper and patient case studies. There are
also opportunities for clinic or laboratory-based project
work, and for observation days following specialists
in fetal medicine, reproductive health, and IVF clinics
(www.instituteforwomenshealth.ucl.ac.uk/education/masters).
Our students
In 2014-15 we had 38 students from the UK and from Bulgaria,
Postgraduate Education Research
Our students
Canada, Chile, China, Greece, India, Iraq, Israel, Japan,
Our graduate research students numbered around 43 in 2015,
Malaysia, Nigeria, Saudi Arabia, Spain, and the USA. It was
with almost two thirds of those students studying for a PhD and
another high achieving year with 15 distinctions and 10 merits.
just over a third for an MD(Res). 74% of these students were
Their research covered a broad range of topics including
female and 26% male.
the effect of E-cigarette flavorings on sperm parameters
and chromatin integrity in vitro, egg freezing, VEGF gene
therapy in fetal growth restriction, obstetric outcomes post
oocyte donation in women with Turners syndrome, hypoxicischemic (HI) brain injury, and chemical conversion of human
mesenchymal stem cells to an earlier state of pluripotency.
Our students have received funding for their reseach degrees
from a variety of sources including public funding bodies
(MRC and NIHR), charities (Wellbeing of Women, Wellcome
Trust/SPARKS Research Training Fellowship, Action Medical
Research, Rosetrees Trust), UCL studentships (Overseas
Research Scholarship, Grand Challenges and IMPACT
Our MSc students,
Studentships), and Commonwealth and overseas government
Natasha Liou, Amy
scholarships.
Duruji, Karimah
Douglas, Shrina
Patel, were active
student academic
representatives
(StARs). Natasha
was appointed
Faculty of Population
Health StAR, and
awarded both the
university-wide Staff
Eight research students (four PhD, one MBPhD, and three
MD(Res)) submitted their theses in 2015. While the majority
of these were submitted in the latter part of the year and so
were still in the process of viva and award as the year drew to
a close, one student, Penny James, was awarded her PhD in
September. Penny’s research project, Cervical antimicrobial
immnunity in pregnancy was supervised by Donald Peebles
and she has gone on to pursue a qualification in Public Health
and Medical History funded by the Wellcome Trust at the
London School of Hygiene and Tropical Medicine.
Choice StAR of the
The Institute has sought to create new support and networking
Year award and the UCL Union’s StAR of the Year award.
opportunities for research students. A peer mentoring scheme
Graduates from 2014-15 have taken up diverse career
opportunities, for example, joining the NHS Scientist Training
Programme in Clinical Embryology, pursuing lab based
work in an academic context in London, and training as a
clinical research associate at Quintiles. Several students have
for new students ran for the second year in 2015 and a new
research student led session at Institute seasonal meetings was
introduced in September 2015. These sessions are intended
to bring research students together quarterly for a range of
presentations, networking and training events.
continued in higher education, starting their research degrees
Panicos Shangaris (PhD student with Anna David) won prizes
at UCL and Oxford. A number of students have begun or
for his presentations at the Neonatal Society and at the Society
continued their clinical careers for example embarking on
for Reproductive Investigation in March 2015. He also won the
a medical degree in Swansea, taking up a resident medical
Joe Leigh Simpson Young Investigator award at International
officer post in Manchester, and pursuing specialty training in
Society for Prenatal Diagnosis and Therapy conference 2015 in
Obstetrics & Gynaeology in London.
Washington DC for his talk on treating thalassaemia in utero.
Research student’s annual day
The 7th annual
research student
Life Learning, Outreach
& Public Engagement
day took place
CPD and face to face courses
on 4 March
Two online distance learning CPD programmes were developed
2015, organised
with the help of the IVF and PGD teams: Preimplantation
by Dimitrios
Genetic Diagnosis and The IVF Laboratory. You can find out
Koutoukidis
more about these programmes on the UCL Life Learning
(Women’s Cancer),
webpages:
Penny James
(Maternal & Fetal
Medicine), Bola Grace (Reproductive Health) and Subha Mitra
(Neonatology). This one day meeting, organised by research
students for research students, is an opportunity for PhD and
MD(Res) students to present their research and to network, and
provides a forum for the exchange of research ideas.
www.ucl.ac.uk/lifelearning/courses/preimplantation-geneticdiagnosis
www.ucl.ac.uk/lifelearning/courses/clinical-ivf-laboratory
In May 2015, the Institute also ran a face-to-face short course
on research methods Making Research Work for Women’s
Health Services. The PGD team ran two workshops in April and
The committee put together an impressive programme of
four in September. We are aiming to develop our CPD and face
IfWH student oral presentations and a diverse range of
to face courses in the future.
invited speakers from Medical Physics and Bioengineering,
Outreach and public engagement
Epidemiology and Public Health, and the Eastman Dental
Hospital at UCL, and the Institue of Cancer Sciences at the
We continue to develop our outreach programme. In 2015 this
University of Manchester. Oral presentation prizes were won
included staff visiting schools of all stages to talk about UCL
by Maria Memtsa (PhD student with Peter Brocklehurst), Harita
and our research. We also ran our third summer school, with
Ghevaria (PhD student with Joy Delhanty) and Jane Currie
15 students from three schools visiting the Institute for a week.
(MD(Res) student with Anna David). Mini oral presentation
The students spent time in different laboratories, research
prizes were won by: Anna Maria Ranzoni (PhD student with
groups and clinical units, meeting students and getting a feel
Pascale Guillot), Julient Baruteau (PhD student with Simon
for life at UCL. Helen was a special guest at Women in Science
Waddington), Razan Jawdat (PhD student with Sioban
– forging new pathways, held at the University of Westminster
SenGupta) and Panicos Shangaris (PhD student with Anna
in February 2015. Joyce Harper set up Global Women
David). As first prize winner of the oral presentation, Maria
Connected with the help of three alumni: Helen O’Neill, Tharni
Memtsa went on to present her research at the Institute Annual
Vasavan and Keeley Monsen. Global Women Connected (www.
Conference in July 2015.
globalwomenconnected.com) is a web based forum to increase
Staying in touch
awareness, learn, share experiences and ask questions
concerning any women’s health issue.
We pride ourselves on keeping in close contact with our alumni,
through various social media forums and various face to face
meetings. In the academic year 2014-2015, many alumni
returned to UCL for a series of career afternoons to offer
current students advice. We held our second alumni network
event on 8th July 2015. It was a great evening with a BBQ
and networking activities. And it was a
pleasure to see the students from 201314 graduate on that day at the Royal
Festival Hall. We look forward to the
graduation ceremony and alumni network
event on 8th July 2016 where we will be
celebrating 20 years of the MSc Prenatal
Genetics and Fetal Medicine.
The UCLH Division
of Women’s Health
Amelia
Godson
Natilla Henry
Divisional
Manager
Head of
Midwifery
Ruwan
Wimalasundera
Clinical Lead
– Obstetrics
Davor
Jurkovic
Donald Peebles
Clinical Director
Clinical Lead
– Gynaecology
Jennifer
Gattuso
Sara Watkin
Clinical Lead
– Neonatology
Clinical Lead
– Breast
For more details go to the UCLH Women’s Health Division website
www.uclh.nhs.uk/OurServices/ServiceA-Z/WH/Pages/Home.aspx
2015 saw increases in clinical activity in maternity,
neonatology, gynaecology and breast.
In gynaecology this was facilitated by a highly successful
move to a dedicated 15 bedded ward (T6 in the UCLH Tower),
a successful business case for new consultant posts in urogynaecology, gynae-oncology and reproductive medicine
and an increase in theatre capacity (from September 2015).
Service changes now ensure that all in-patients are reviewed
by a consultant 7 days a week.
In maternity we welcome Natilla Henry, who takes over
from Vivienne Knight as Head of Midwifery. Two obstetric
consultant posts have been created to increase consultant
presence on the labour ward to 96 hours a week but
substantive appointments are yet to be made.
We welcome Cally Tan as a new consultant neonatologist.
As a first step in a strategy to expand the breast service we
We have also strengthened our safety team with the
have strengthened the consultant workforce and plan to do
appointment of a safety midwife and a Risk Manager who
the same in nursing next year.
joins us in June 2016.
In September the Division played a major role in co-ordinating
Offering choice of place of birth resulted in 17.4% of women
celebrations for the 150th anniversary of Elizabeth Garrett-
using our service giving birth in our midwifery led birthing
Anderson, the UK’s first female doctor and after whom a wing
centre in 2015; our aim is to increase this to at least 20%.
of UCLH is named.
We welcome Jan Deprest, a world leading expert on fetal
Many congratulations to Melissa Whitten on being voted
surgery, who has started a part-time appointment to lead a
Regional Trainer of the Year by the trainees themselves (she
multidisciplinary team of clinicians and scientists to develop
came runner up nationally) and Georgina Fox on winning the
treatments for spina bifida and congenital diaphragmatic
Kindness Award at the Trust Celebrating Excellence awards.
hernia.
Engagement in national research in Women’s Health remains
Neonatology saw a record 1028 admissions in 2015 as well as
high with over 5,000 women recruited to Portfolio studies,
impressive performance figures in the National Neonatal Audit
supported by the CRN funded Research Team who are
Programme.
increasingly enabling us to recruit well to such studies.
Centre for Ethics
in Women’s Health
Throughout 2015, work on developing a
fully-fledged Centre for Ethics in Women’s
Health at IfWH has continued, with exciting
early results in the three main areas of
intended work: research, education and
public engagement. Research Research in ethics of women’s health is already embedded
into several major research programmes at the Institute. The
Centre for Ethics is intended as a hub where this knowledge
and insights can be promoted and shared across departments
and institutions.
One such example that was started in April 2015 is an
audit of the management of women who have undergone
female genital mutilation (FGM). The audit involved a group
of final-year medical students interviewing consultants,
junior doctors and nurse practitioners at UCLH’s Emergency
Department. They were asked about their communication,
documentation and management of women with FGM, as well
as safeguarding girls at risk. The audit uncovered low levels
of knowledge and confidence about FGM. Strikingly, over the
previous 12 months, none of the 51 healthcare professionals
interviewed had referred anyone with FGM to UCLH’s own
specialist FGM Clinic, even when women had presented
with relevant symptoms, such as recurrent UTIs or problems
following labour.
The audit led to new training sessions and improved paediatric
management guidelines for staff, the introduction of posters
and patient leaflets in the Emergency Department, as well as
clearer referral pathways. The UCLH FGM training module,
developed with Sarah Creighton, was adopted by Health
Education England and made part of national mandatory
training (http://fgmtoolkit.org). The audit was presented at the
RCOG National Trainee Conference in December 2015, where it
won a price for best audit in its category. UCL EGA Institute for Women’s Health
Education Public engagement In April 2015 Anthony Smith, Vice-Provost (Education &
In January, the Institute hosted an evening
Student Affairs) issued a call for applications for UCL’s first
for FGM survivors and asylum-seekers
ever ‘massive online open course’ call. So-called MOOCs are
affected by FGM. Over 100 people
free online courses, open to everyone, made possible through
attended and were able to listen first-
a collaboration with FutureLearn, a non-profit learning platform
hand to personal experiences of women
and a wholly owned subsidiary of the Open University. UCL
forced to flee their communities due to
wanted to create three initial courses, as part of the Connected
the practice. In March, as part of the weeklong events marking
Curriculum strategy to support a research-based approach
International Women’s Day, the Centre for Ethics hosted a
to education. Our application for a course on the ethics of
successful debate on the topic of egg freezing and fertility
assisted reproduction was successful, and £20,000 funding
planning. Joyce Harper debated the issue of egg freezing with
was made available for course development. Due to launch in
Nicky Hudson, a social scientist and an expert on the ethics
June 2016, the course is expected to form part of the blended
of fertility preservation from De Montfort University. Over 120
learning components on the current MSc programmes and the
people attended the session, which amongst other things
new iBSc course in Women’s Health.
highlighted the difficulties that women encounter when their
employers encourage them to freeze their eggs. Coming up
Next year will see several more ethics-oriented MSc
projects, and further development of the Ethics in Women’s
Health teaching programme. Anyone interested in being
part of this, whether current members or alumni, should
contact Dan Reisel ([email protected]).
Global Health
The IfWH programme for helping improve
women’s and newborn health worldwide
Apart from the specific international research and other
initiatives undertaken in each of the Institute’s four main
departments, we also work more generally, on a cross-cutting
basis, towards improving maternal and newborn health
worldwide. This work has a renewed focus with the introduction
of the new United Nations Sustainable Development Goals;
Goal 3 of which covers universal access to health care with its
specific WHO driven sub targets relating to maternal and child
health. Our work involves collaboration with many national and
international agencies and professional organisations, specific
Governments and academic institutions in both resource rich
and resource poor countries of the world.
The programme is led by Gwyneth Lewis, an expert on
international women’s, maternal, and public health with
many years’ experience in the UK and globally. Her particular
interests lie in the area of health care quality improvement and
guideline development, implementation and evaluation and
using the results of maternal and perinatal death and near miss
audits and reviews to generate beneficial changes in clinical
Last year’s report highlighted the development and introduction
practice as well health care policies and local and national
of the highly successful film “Why Did Mrs X Die; retold”. This
priority settings. She is also in interested in the development
year, again working with the charity Hands On for Mothers and
and evaluation of appropriate educational programmes, tools
Babies (www.hofmab.com/about) an already widely acclaimed
and technologies for health care staff and the communities
board game, based on the film entitled “Walking with Mrs X”
which they serve.
has been published. It is available in hard copy or to download
Over the past year Gwyneth Lewis, with other, has run several
workshops in the Balkans, Southern and Eastern Europe and
Central Asia for the development and introduction of suitable
methodologies to review maternal and perinatal deaths and
near miss severe obstetric morbidity to improve the quality of
care provided in these setting. A toolkit based on 15 years’
practical experience is in preparation for the Regional European
Offices of UNFPA, UNICEF and WHO which will offer realistic
and practical advice on the development, implementation and
evaluation of such programmes. It is planned to pilot near
miss reviews in obstetric haemorrhage and pre-eclampsia in
at least one of these countries in the forthcoming year. Work
for free and was launched at the global Safe Motherhood
meeting in Mexico in December 2015. Offers to translate it into
over 20 languages have already been received. It is planned
to evaluate its impact as a teaching tool very shortly. Together
with Medical Aid Films (www.medicalaidfilms.org), another
charity which develops innovative media programmes to
enable learning and education, and which is closely associated
with the IfWH, is developing a “walk through” virtual game
which can reach out on a variety of platforms to make these
messages even more accessible to all. MAF has now develop
over 190 teaching and training films in the area of adolescent,
reproductive, maternal and newborn health.
is also ongoing with collaboration with several US States and
Future plans include developing a teaching centre and
professional associations to share learning on the practicalities
comprehensive educational programme for doctors and
of developing quality maternal and newborn health care
midwives in West Africa which will then be evaluated in specific
programmes, particularly in the public sector, through the use
settings. Work on evaluating the impact of different teaching
of reviews and guideline development. More generally, advice
methodologies is also in its initial phase of development.
and support for the development of nationwide consistent
high quality maternal and newborn health services has been
provided to the Government of Mauritius.
Research Department of
Reproductive Health
Joyce
Harper
Sioban
SenGupta
Embryology,
IVF and
Reproductive
Genetics
Preimplantation
Genetics
Judith Stephenson
Head of Research Department;
Sexual and Reproductive Health
The Research Department of
Reproductive Health hosts a
multidisciplinary team of clinicians
and scientists with expertise in a wide
range of disorders affecting womens’
reproductive health.
Our research portfolio spans molecular
investigation into the health of oocytes
(eggs) and embryos, through clinical
research of common gynaecological
conditions, such as endometriosis
and polycystic ovary syndrome, and
rare disorders of sexual development,
to public health issues such as preconception health and control of
sexually transmitted infections.
Sarah
Creighton
Paul
Hardiman
Gynaecological
Development
and Function
Polycystic Ovary
Syndrome
Ratna
Chatterjee
Reproductive
Health in Chronic
Diseases
For more details go to the Reproductive Health website
www.instituteforwomenshealth.ucl.ac.uk/reproductive-health
Improving young women’s
informed choice of
contraception
New Seed Funding scheme
for Sexual & Reproductive
Health (SRH) clinical research
Stephenson J, Bailey J, Gubijev A
Stephenson J, Mann S.
A commissioned NIHR HTA funded study (PI Stephenson) to
With funding from Central and North West London NHS
help young women optimize their choice of contraception. We
Foundation Trust linked to an NIHR senior investigator award,
will conduct qualitative research with young women to develop
Judith Stephenson started a seed funding scheme to help
a new online intervention suitable for use in five service settings
frontline Sexual and Reproductive Health clinicians bring to life
– general practice, Sexual and Reproductive Health services,
their ideas for clinical research. IfWH staff support colleagues
abortion services, maternity care and community pharmacies.
to submit high quality research proposals to the scheme.
This development phase will be followed by a series of
Projects funded so far include an evaluation of routinely offering
pilot randomized controlled trials – one in each setting – to
extended use of the combined contraceptive pill, evaluation
determine which approaches are most likely to be successful
of routine enquiry about domestic violence, improving access
in helping choose an effective contraceptive method that suits
to specialist services and understanding why women choose
women’s needs.
Long-Acting Reversible Contraception (LARC) which includes
contraceptive implants, intra-uterine methods and injections.
Top 10 Priorities for Research
in Contraceptive Care
Stephenson J
In 2015, Judith Stephenson
Embryology, IVF and
Reproductive Genetics
Harper J, O’Neill H
was awarded funding from
In 2015, two initiatives were developed with the British Fertility
the Faculty of Sexual &
Society (BFS) of which Joyce Harper is an executive board
Reproductive Health to set up
member. Joyce led on a joint BFS and Association of Clinical
a Priority Setting Partnership
Embryologists (ACE) position paper on embryo selection
(PSP) in Contraceptive Care,
about how to choose the ‘best’ embryo (Bolton, V.N., Leary,C.,
supported by the James Lind
Harbottle, S., Cutting, R., Harper, J.C. (2015) How should we
Alliance. The PSP follows
choose the “best” embryo? Human Fertility, 18(3), 156-164.)
a robust, evidence based
Joyce became a key member of the Fertility Health Task Force,
process of establishing the top
a group of senior professionals from health, education and
10 priorities for research in contraceptive care jointly with users
government who want to improve young people’s knowledge of
and clinicians. This is the first time that the specialty of Sexual
fertility and reproductive health in the UK.
and Reproductive Health (SRH) has systematically engaged
with the public about the kind of contraceptive research they
think we should be doing on their behalf.
Global Women Connected
Fertility Awareness Research
Grace B, Stephenson J
In 2015 Joyce Harper
established Global Women
Connected with the help of
With funding from
Elena Kontogianni, Laura
Clearblue SPD
Witjens Helen O’Neill, and
for a new PhD
alumni Tharni Vasavan,
studentship, Bola
Keeley Monsen. (www.
Grace is investigating the current level of fertility knowledge,
globalwomenconnected.com).
attitudes and awareness of secondary school pupils, men and
women of reproductive age and health care professionals.
The project aims to identify opportunities to improve fertility
knowledge and awareness to enable men and women achieve
their desired fertility intentions.
Global Women Connected
Global Women Connected is an interactive forum which discuss
a wide range of women’s health issues including puberty, sex,
fertility, pregnancy, menopause, cancer, global issues, gender
equality and mental health.
VESPA (Variations in
the organization of Early
Pregnancy Assessment Units)
Jurkovic D
Davor Jurkovic was awarded NIHR funding from the Health
Services and Delivery Research Programme for a study to
examine the different configurations of Early Pregnancy
Assessment Units (EPAUs) and their impact on key outcomes.
EPAUs provide a specialised clinical service for women with
UCLH/UCL Centre for
Human Reproduction
In 2015 Joyce Harper established the UCLH/UCL Centre for
Human Reproduction to bring together the IfWH research
department of Reproductive Health and the University College
London Hospital clinical departments of Reproductive Medicine
(RMU), the Centre for Reproductive and Genetic Health
(CRGH), UCH Urology and related departments. The Centre
suspected early pregnancy complications, predominantly
miscarriage and ectopic pregnancy. Across the country there is
significant variation in organisational structure, size and staffing
levels. VESPA will examine how this variation affects rates of
emergency hospital admission and non-diagnostic ultrasound
scans, patient satisfaction with quality of care received and
staff experience of providing care.
Global reproductive health
Hall J, Stephenson J
aims to be a global leader in the life course of reproductive
Using data from a Wellcome Trust funded study of 4244
health by working on clinical, scientific, educational and public
pregnant women in Malawi, we have shown that unplanned
engagement projects.
pregnancies are associated with postnatal depression and,
possibly stillbirth. Unplanned pregnancies were also associated
Preimplantation
Genetics Research
SenGupta S, Delhanty J
We are investigating how chromosomal abnormalities arise in
with lower uptake of preventative care before, during and
after pregnancy. We are planning to take this work forward to
explore the longer term impacts of unplanned pregnancy on the
mother and child in Malawi.
Morroni C
human oocytes and embryos to determine causes of infertility.
As part of UCL’s Global Engagement Strategy, a formal
Analysis of single oocytes showed that 30% were aneuploid due
collaboration has been established between UCL and the Wits
to germinal mosaicism, independent of maternal age. Over 60% of
Reproductive Health and HIV Institute. The current research
embryos from chromosome translocation carriers had widespread
programme, led by Chelsea Morroni, centres on five key
additional aneuploidies contributing to the couple’s infertility.
areas: contraception and HIV; use of long-acting reversible
Inefficient energy production may lead to aneuploidy therefore we
contraceptives; understanding of pregnancy intention/
are studying the interaction between the mitochondrial genome
planning; safe abortion access; and management of sexually-
and the nuclear genome in embryos using sequencing.
transmitted infections.
Since it was established in 1997, the PGD Centre has had over
Chatterjee R
1200 referrals, leading to 545 treatment cycles, 154 deliveries and
the birth of 170 healthy babies. There have been no misdiagnoses.
Female Genital Mutilation
Creighton S
In their programme of haemoglobinopathy research, including
reproductive health, puberty and public health implications,
Ratna Chatterjee and Rekha Bajoria are collaborating with
colleagues in Tanzania (Julie Makhani), China (Pan, University of
Guanxei) and the UK (James Moon and Amna Abdel).
Sarah Creighton was awarded £160,000 from University
College London Hospitals Trustees to study “Clitoral
reconstruction following Female Genital Mutilation (FGM): the
first inter-disciplinary scientific evaluation.”
Highlights
Pateman K., Holland T.K., Knez J., Derdelis, G., Cutner,
Judith Stephenson received a ‘women of achievement’
ultrasound examination of the complete urinary tract
A., Saridogan, E., Jurkovic, D. (2015) Should a detailed
award for health care from Women-in-the-City.
be routinely performed in women with suspected pelvic
www.citywomenwoaaward.co.uk/judith-stephenson
endometriosis? Human Reproduction, 30(12):2802-7.
Chelsea Morroni was appointed special advisor in sexual &
Phelan, N., Williams, E.L., Cardamone, S., Lee, M., Creighton,
reproductive health to the Botswana Ministry of Health and
S.M., Rumsby, G., Conway, G.S. (2015). Screening for
set up the first doctor-led referral service in Botswana.
mutations in 17b-hydroxysteroid dehydrogenase and
Ertan Saridogan was a Congress President of the 24th Annual
androgen receptor in women presenting with partially virilised
Congress of the European Society for Gynaecological
46,XY disorders of sex development. European Journal of
Endoscopy 2015.
Endocrinology, 172 (6), 745-751.
Gerry Conway was a Chair of Adult Section of International
Sarri G., Davies M., Lumsden M.A. (2015) Diagnosis and
Guidelines for Management of Turner Syndrome – European
Management of Menopause: summary of NICE guidance. BMJ,
Society for Endocrinology.
351:h5746.
Sarah Creighton, Sohier El-Neil and Judith Stephenson
SenGupta, S.B., Dhanjal, S., Harper, J.C. (2015) Quality
authored chapters in the Chief Medical Officer’s Annual
control standards in PGD and PGS. Reproductive BioMedicine
Report on Women’s Health.
Online, epub.
Lisa Webber and Melanie Davies co-chaired the ESHRE
Tulay, P., Naja, R.P., Cascales-Roman, O., Doshi, A., Serhal, P.,
Guideline Development Group on the Management of
SenGupta, S.B. (2015). Investigation of microRNA expression
Premature Ovarian Insufficiency.
and DNA repair gene transcripts in human oocytes and
Melanie Davies was appointed as a Medical Advisory
Committee member for the British Menopause Society.
blastocysts. Journal of Assisted Reproduction and Genetics, 32
(12), 1757-1764.
Wellings, K., Brima, N., Sadler, K., Copas, A.J., McDaid, L.,
Important publications
Mercer, C.H., ...Stephenson, J., Glasier, A. (2015). Stopping
Barrett, G., Shawe, J., Howden, B., Patel, D., Ojukwu, O.,
a prospective longitudinal study of women of reproductive age
Pandya, P., Stephenson, J. (2015). Why do women invest in
in England. Contraception, 91 (1), 57-66.
and switching contraceptive methods: Findings from Contessa,
pre-pregnancy health and care? A qualitative investigation with
women attending maternity services. BMC Pregnancy and
Childbirth, 15 (1).
Bolton, V.N., Leary,C., Harbottle, S., Cutting, R., Harper, J.C.
(2015) How should we choose the “best” embryo? Human
Fertility, 18(3), 156-164.
Coming up
The Rank Prize Funds Mini-Symposium on
Developmental Programming for Human Disease:
Preconception Nutrition & Lifelong Health to be co-
Chronopoulou, E., Harper, J.C. (2015). IVF culture media: past,
chaired by Judith Stephenson and Mary Barker,
present and future. Human Reproduction Update, 21 (1), 39-55.
Associate Professor of Psychology at Southampton
Girardet, A., Viart, V., Plaza, S., Daina, G., De Rycke, M., Des
Georges, M., ...SenGupta, S.B., …Claustres, M. (2015). The
improvement of the best practice guidelines for preimplantation
General Hospital.
Chelsea Morroni will be leading an introduction of
contraceptive implants into Botswana.
genetic diagnosis of cystic fibrosis: toward an international
consensus. European Journal of Human Genetics, epub.
Hodes, D., Armitage, A., Robinson, K., Creighton, S.M. (2015).
Female genital mutilation in children presenting to a London
safeguarding clinic: a case series. Archives of Disease in
Childhood, epub.
Liao, L.M., Wood, D., Creighton, S.M. (2015). Parental choice
on normalising cosmetic genital surgery. BMJ, 351.
Maternal and Fetal Medicine
Peter
Brocklehurst
Anna David
Prenatal Cell and
Gene Therapy
Clinical Trials in
Pregnancy
Donald Peebles
Preterm Birth
2015 has been an exciting year with
advances being made in a number of new
gene or cell based therapies for perinatal
treatment of congenital disease. The EU
funded EVERREST project to deliver first
in human gene therapy to treat severe fetal
growth restriction received a favourable
scientific review by the European Medicines
agency and is recruiting well to its first stage.
Anna David was a successful applicant on a
Swedish grant to treat brittle bone disease.
The GIFT-Surg collaboration with the newly
formed Institute of Healthcare Engineering
is proving really successful with new PhD
students and projects commencing; the
potential for introducing new imaging and
operative techniques to deliver these new
therapies early in pregnancy is getting
closer. At the same time the work of David
Williams’s group investigating the complex
relationship between maternal genetics,
epigenetics, immunology and vascular and
hepatic physiology continues to provide new
insights into the pathophysiology of rare
but important pregnancy syndromes. Our
ability to translate these findings into clinical
practice took a major step forward with
the part-time appointment of Jan Deprest,
Professor of Obstetrics and Gynaecology, a
world leading expert in fetal surgery.
David
Williams
Simon
Waddington
Maternal
Medicine
Gene Transfer
Technology
Pascale V
Guillot
Mariya
Hristova
Cellular
Reprogramming
and Perinatal
Therapy
Perinatal Brain
For more details go to the Maternal and Fetal Medicine website
www.instituteforwomenshealth.ucl.ac.uk/maternal-fetal-medicine
New molecular targets for
reduction and prevention of
hypoxia-ischaemia induced
brain damage
to plan fetal surgical procedures, with little evidence that they
Hristova M, Rocha-Ferreira E, Fontana X, Thei L, Buckle R,
Tracking the needle
during ultrasound guided
procedures made easy
Christou M, Hompoonsup S, Gostelow N, Raivich G, Peebles D
Hypoxic-ischemic (HI) encephalopathy is leading cause of
child mortality and morbidity. Hypoxia-ischemia (HI) strongly
up-regulates Signal Transducer and Activator of Transcription 3
(STAT3) in the immature brain. The Perinatal Brain Repair Group
has recently shown that neuron-specific and astroglia-specific
have improved outcomes. With the GIFT-Surg team, members
of the Institute for Women’s Health are developing fetalspecific technology for surgical planning that is likely to play an
important role in the future for complex fetal surgeries.
Xia W, Mari JM, West SJ, Ginsberg Y, David AL, Ourselin S,
Desjardins AE
STAT3-deletion, and systemic pre-insult STAT3-inhibition at
tyrosine 705 (Y705) improves neuronal survival and reduces
HI induced brain damage. These findings, recently published
in the Journal of Neurochemistry suggest that STAT3 is a
crucial factor in neonatal HI-brain damage and its removal in
neurons or astrocytes, and inhibition of its phosphorylation via
JAK2-blockade reduces inflammation and tissue loss. Thus
the protective effects of STAT3 inactivation make it a possible
target for a therapeutic strategy in neonatal HI.
Accurate and efficient guidance of needles is critically important
during ultrasound guided fetal medicine interventional
procedures. Uncertainties about the location of the needle
tip within the image plane can lead to significant difficulties
especially, if the target is deep or the operator is inexperienced.
Working with the GIFT-Surg medical physicists, Yuval Ginsberg, a
visiting clinical research fellow from Israel tested out a method for
directly visualizing the needle tip using a fiber-optic ultrasound
receiver integrated into the needle cannula in conjunction with
the imaging probe used to acquire B-mode ultrasound images.
In a preclinical study published in the journal Medical Physics,
the needle tip could be easily visualized at steep insertion angles
and large tissue depths. Further work is developing a method to
visualize the needle when it is out of plane.
Computer-assisted fetal
surgical planning to
improve outcomes
Pratt R, Deprest J, Vercauteren T, Ourselin S, David AL
Fetal surgery interventions such as laser treatment for twinto-twin transfusion syndrome (TTTS) and open fetal surgery
for spina bifida have demonstrated in randomised controlled
trials that they improve neonatal outcome. Other specialities
Development of rAAVmediated gene therapy for a
severe paediatric metabolic
liver disease: Ornithine
Transcarbamylase deficiency
Gissen P, Thrasher A, Waddington S, Baruteau J, Ridout D,
Chan-Porter F, Alexander I
are increasingly using computer-assisted surgical planning
Ornithine transcarbamylase
software to improve outcome. Rosalind Pratt, a clinical PhD
is a devastating inherited
student in the GIFT-Surg research team published a systematic
metabolic disease. Severe
review in Prenatal Diagnosis about fetal surgical planning. She
mutations result in elevation
found that studies are currently limited to creating 3D models
of blood ammonia levels in
the blood of the infant which may cause irreversible damage to
the brain and even death. Liver transplantation is the only curative
Highlights
option at the moment. This preclinical project aims to use gene
therapy to support the infant until a donor can be found.
Acute fatty liver of pregnancy
Kaler M, Williams DJ
Mandeep Kaler, a clinical PhD student, is investigating the
pathogenesis of acute fatty liver of pregnancy. This rare
gestational condition affects only 1:10,000 pregnancies, but
can have catastrophic effects on both maternal and fetal
wellbeing. Mandeep is searching for sub-clinical defects in fatty
acid oxidation in affected families. Phenotyping studies are
linked with whole genome sequencing of affected families.
The 2nd International Conference on In Utero Transplantation
and Fetal Gene Therapy was organised by members of
the Institute for Women’s Health (Anna David, Simon
Waddington and Pascale Guillot) and Institute of Child
Health in October 2015.
Anna David was an Invited Speaker and Panel Member at
Turning amniotic fluid
into lungs
Guillot P, Tommasini F
Fabio Tommasini, a
second year UCLfunded PhD student,
the European Commission Conference: Together for the
Next Generation: Research and Innovation for Maternal and
Newborn Health. Brussels, December 2015.
Anna also spoke at the 14th World Congress in Fetal
Medicine, Crete, Greece in June 2015 on Maternal gene
therapy to improve fetal growth.
Panicos
working with Pascale
Shangaris won
Guillot, has shown that
the Joe Leigh
human amniocytes
Simpson Young
are more efficiently
Investigator
reprogrammed to pluripotency than more commonly used
Award 2015 at
fibroblasts and also have a higher efficiency to differentiate
the International
down the definitive endoderm pathway, making the cells ideal
Society of
candidate for the development of lung tissue.
Prenatal
diagnosis and
therapy.
Glowing bacteria and
preterm birth
Rajvinder Karda was a runner-up in the British Society for Gene
Suff N, Waddington S, Peebles D
Simon Waddington gave a talk
and Cell Therapy Fairbairn Young Investigator Award 2015.
With the help of funding from Magnus Growth, Natalie Suff,
on “Gene Therapy: Hacking
a clinical PhD student on a Wellbeing of Women funded
our genetic code”, as part of
fellowship has demonstrated that bacteria tagged with a
The Darwin Centre’s British
bioluminescent marker will ascend into the uterus (see picture
Science Week and to the Tasker
below) from the mouse vagina. This occurs even if the mouse
Millward School’s pupils in
is pregnant and can lead to premature delivery. She is now
Pembrokeshire in March 2015.
seeing whther this process can be prevented with the use of
endogenous proteins that are known to kill bacteria.
Sara Hillman was appointed
as an NIHR Clinical lecturer for
4 years. Sara had previously
completed her PhD under the
supervision of David Williams.
Penny James was awarded her PhD.
Di Trapani, M., Bassi, G., Fontana, E., Giacomello, L.,
Pozzobon, M., Guillot, P.V., ...Krampera, M. (2015). Immune
regulatory properties of CD117(pos) amniotic fluid stem
cells vary according to gestational age. Stem Cells and
Development, 24 (1), 132-143.
Coming up
The INFANT trial is comparing the effect of a computer
based ‘intelligent’ system to support decision making
in the management of labour using the cardiotocogram
(CTG) by clinicians (midwives and doctors) versus
review by clinicians (midwives and doctors) with no
Finer, S., Mathews, C., Lowe, R., Smart, M., Hillman, S.,
computer based decision support in women who
Foo, L., …Williams, D., …Hitman, G.A. Maternal gestational
require continuous CTG monitoring of their labour. The
diabetes is associated with genome-wide DNA methylation
trial recruited over 46,000 women and will reveal its
variation In placenta and cord blood of exposed offspring.
finindings in 2016.
(2015). Human Molecular Genetics, 24 (11), 3021-9.
Hunter, P.J., Sheikh, S., David, A.L., Peebles, D.M., Klein, N.
(2015). Cervical leukocytes and spontaneous preterm birth.
Journal of Reproductive Immunology, epub. doi:10.1016/j.
jri.2015.11.002
Mattar, C.N., Wong, A.M.S., Hoefer, K., Alonso-Ferrero, M.E.,
Buckley, S.M.K., Howe, S.J., …Waddington, S.N., ...Rahim,
A.A. (2015). Systemic gene delivery following intravenous
administration of AAV9 to fetal and neonatal mice and lategestation nonhuman primates. FASEB Journal, 29 (9), 3876-3888.
Rocha-Ferreira, E., Phillips, E., Francesch-Domenech, E.,
Thei, L., Peebles, D.M., Raivich, G., Hristova, M. (2015). The
Role Of Different Strain Backgrounds In Bacterial EndotoxinMediated Sensitization To Neonatal Hypoxic-Ischemic Brain
Damage. Neuroscience, 311, 292-307.
Xia, W., Mari, J.M., West, S.J., Ginsberg, Y., David, A.L.,
Ourselin, S., Desjardins, A.E. (2015). In-plane ultrasonic needle
tracking using a fiber-optic hydrophone. Medical Physics, 42
(10), 5983-5991.
Research Department
of Neonatology
Neil
Marlow
Judith
Meek
Neurodevelopment and
Neurocognitive
Outcomes;
Neonatal Clinical
Trials
Neonatal Pain
Nicola J Robertson
Head of Neonatology Research
Department; Pre-clinical Neonatal
Neuroprotection; Neonatal
Neuroimaging and Biomarkers
The Research Department
of Neonatology hosts a
multidisciplinary team of
neonatologists, scientists,
physicists and engineers all
focused on optimising the care
of the newborn baby with a
particular focus on protecting
the developing brain.
Our research portfolio includes preclinical studies in a translational
model of birth asphyxia with the
view to developing a pipeline of
neuroprotective treatments for
babies, basic neuroscience and
molecular investigation into brain
injury and protection, biomarker
development and validation
studies using magnetic resonance
techniques, pain studies, studies of
neonatal seizures, neonatal clinical
trials, research into neurocognitive
outcomes and global health
research in Sub Saharan Africa.
Janet
Rennie
Cally Tann
Neonatal
Global Health
Neonatal
Seizures
For more details go to the Neonatology website
www.instituteforwomenshealth.ucl.ac.uk/neonatology
Reducing the burden of
neonatal brain injury: testing
neuroprotective agents in an
inflammation sensitised model
TOBY Xenon Baby study
reported in Lancet Neurology
Dec 2015
Robertson NJ, Dinan, M, Kendall G
Robertson NJ, Golay X, Tachtisidis I
The sensitizing effect of inflammation and infection in neonatal
encephalopathy (NE) and neurodisability is increasingly
recognized. Therapeutic hypothermia is only partially effective
and may not be effective in inflammation-sensitized NE.
We started an MRC funded project to develop a new model
of inflammation sensitized NE in which we can test novel
neuroprotective agents such as melatonin. We envisage
these studies leading to the future tailoring of neuroprotective
treatments to specific babies.
Total Body hypothermia plus Xenon (TOBY-Xe) was a proofof-concept, randomised, open-label, parallel-group trial done
at four intensive-care neonatal units in the UK, including UCL.
We enrolled 92 infants, 46 of whom were randomly assigned
to cooling only and 46 to Xenon plus cooling. The mean age of
starting xenon was 10 hours. Administration of xenon within the
Magnesium sulfate for hypoxic- delayed timeframe used in this trial is feasible and apparently
safe, but is unlikely to enhance the neuroprotective effect of
ischaemic encephalopathy at
cooling after birth asphyxia.
term: A safety and efficacy
study of single and combined
EPICure@19
therapy with cooling
Marlow N, Morris J, Johnson S, Wolke D, Golay X, Ourselin S,
Robertson NJ, Golay X, Tachtsidis I, Lingam I
Walker S, Rees G, Hurst J, Cockcroft J, Beckmann J, O’Reilly
H, McCormack L, Bennett K, Morgan A, Dyer J
There is an important, unmet need for adjunct therapies to
further improve the outcome of neonatal encephalopathy
(NE). Meta-analyses of large controlled trials now suggest
that maternal magnesium sulfate therapy is associated with
This national cohort study concludes data collection during
reduced risk of cerebral palsy and gross motor dysfunction
the Autumn of 2016. All young people who were born at 22-25
after premature birth. It is unknown whether MgSO4 is
weeks gestation in 1995 have been invited to an assessment
beneficial in term infants. We started a study to determine
over two days in the Clinical Research Facility in the EGA wing
whether a magnesium infusion is safe and whether it augments
of UCLH. We are studying a broad selection of outcomes from
hypothermic neuroprotection. The insights gained through
psychology, pain sensitivity, lung and cardiovascular function
this study will validate the potential of magnesium mono-
to determine the effect on preterm birth. Andrei Morgan
and combined therapy for NE; provide a more complete
completed his PhD based on EPICure 2 data.
understanding of magnesium’s neuroprotective mechanisms;
See www.epicure.ac.uk.
provide vital information on pharmacokinetics and optimal
dosing of magnesium.
Mitogent – understanding
deafness in preterm children
Chant K, Bitner-Glindzicz M, Marlow N
Optimal techniques for noninvasive measurement of
jaundice
Meek J, Leung T (Medical Physics)
In this study we are examining the role of m.1555 A>G mutation
in the genesis of hearing loss among very preterm children,
among a range of other factors including the use of gentamicin.
This study completed data collection in 2015 and is part of K
Chant’s PhD thesis. See www.ucl.ac.uk/mitogent.
Parents and Neonatal
Decisions Study
Marlow N, Gallagher K, Shaw C, Alagandagy N
This study used the colour of a baby’s sclerae to screen for
jaundice. This method of estimating jaundice was seen to be as
effective as current methods (eg. transcutaneous).
During 2015 we continued to develop this project evaluating the
conversational dynamics of end of life conversations between
doctors and parents in neonatal intensive care. In partnership
Global Newborn Health
Tann CJ, Robertson NJ
with Elizabeth Stokoe of Loughborough University we designed
and ran the first workshop using Conversational Analytic Role
Play methods with 25 neonatologists. This work has formed the
basis of an application to NIHR in Autumn 2015.
See www.ucl.ac.uk/pnd.
British Pediatric Surveillance
Unit Methodology for Exchange
blood transfusion
Rennie J, Hannan S
The ABAaNA study, which examines risk factors for and
longer-term outcomes from neonatal encephalopathy
The aim of this
in Uganda, completed follow-up of the study children
study is to ascertain
at two years of age. A quarter of survivors of neonatal
the incidence and
encephalopathy were found to have significant learning
outcome of babies
disability or cerebral palsy by two years. An ABAaNA Open
undergoing neonatal
Day was held in March to communicate the study findings
exchange blood
to participating families and key-stakeholders. Cally Tann is
transfusions in the
currently funded to develop and pilot an early intervention
UK and Republic
programme to improve the health, well-being and quality of
of Ireland. We have
life of affected children and their families.
used standard
British Paediatric
Surveillance Unit
methodology for our data capture.
See www.rcpch.ac.uk/bpsu/ebt.
Highlights
Ezzati, M., Bainbridge, A., Broad, K.D., Kawano, G., Oliver-
Nikki Robertson was awarded the UK Neonatal Society
Hristova, M., Bennett, K., …Robertson, N.J. (2015). Immediate
Taylor, A., Rocha-Ferreira, E., ...Alonso-Alconada, D., …
David Harvey Senior Fellowship in March 2015. She
remote ischemic postconditioning after hypoxia ischemia
was selected by the Committee who were looking
in piglets protects cerebral white matter but not grey
for candidates that have improved the wellbeing of
matter. Journal of cerebral blood flow and metabolism: official
underserved populations or addressed understudied
journal of the International Society of Cerebral Blood Flow and
problems, through high quality research.
Metabolism, epub.
Nikki Robertson delivered her Inaugural Lecture in May 2015.
Lees, C.C., Marlow, N., Van Wassenaer-LeemhuiArabin, B.,
Bilardo, C.M., Brezinka, C., ...Duvekot, J.J. (2015). 2 year
Nikki Robertson and her research team.
neurodevelopmental and intermediate perinatal outcomes in
Inaugural lecture May 2015, UCL
infants with very preterm fetal growth restriction (TRUFFLE): A
randomised trial. The Lancet, 385 (9983), 2162-2172.
Linsell, L., Malouf, R., Morris, J., Kurinczuk, J.J., Marlow, N.
(2015). Prognostic Factors for Poor Cognitive Development in
Children Born Very Preterm or With Very Low Birth Weight A
Systematic Review. Jama Pediatrics, 169 (12), 1162-1172.
Marlow, N. (2015). The elephant in the delivery room. New
England Journal of Medicine, 372 (19), 1856-1857.
Pressler, R.M., Boylan, G.B., Marlow, N., Blennow, M.,
Chiron, C., Cross, J.H., ...Jullien, V. (2015). Bumetanide for
the treatment of seizures in newborn babies with hypoxic
ischaemic encephalopathy (NEMO): An open-label, dose
Cally Tann successfully defended her PhD and was presented
with a Young Investigator Award at Neonatal Update 2015:
“the science of newborn care” conference where she
presented a resume of her research achievements.
finding, and feasibility phase 1/2 trial. The Lancet Neurology, 14
(5), 469-477.
Stevenson, N.J., Clancy, R.R., Vanhatalo, S., Rosen, I., Rennie,
J.M., Boylan, G.B. (2015) Interobserver agreement for neonatal
seizure detection using multi-channel EEG. Annals of Clinical
and Translational Neurology, 2 (11),1002-11.
Alonso-Alconada, D., Broad, K.D., Bainbridge, A.,
Chandrasekaran, M., Faulkner, S.D., Kerenyi, Á., ... RochaFerreira, E., Hristova, M., …Bennett, K., …Robertson, N.J.
(2015). Brain cell death is reduced with cooling by 3.5°C to
5°C but increased with cooling by 8.5°C in a piglet asphyxia
model. Stroke, 46 (1), 275-278.
Azzopardi, D., Robertson, N.J., Bainbridge, A., Cady, E.,
Charles-Edwards, G., Deierl, A., …Edwards, A.D. (2015)
Moderate hypothermia within 6 h of birth plus inhaled xenon
versus moderate hypothermia alone after birth asphyxia (TOBYXe): a proof-of-concept, open-label, randomised controlled trial.
Lancet Neurology, epub.
Eaton-Rosen, Z., Melbourne, A., Orasanu, E., Cardoso, M.J.,
Modat, M., Bainbridge, A., ...Kendall, G.S., Robertson, N.J.,
Coming up
Collaboration with Boris Kramer, University of Maastricht,
who is seconded to UCL part time in 2016 to develop
his interests in lung inflammation and trials of ventilation
strategies in preterm babies.
Nikki Robertson and Subha Mitra will visit University
of Auckland in August 2016 to develop research
collaborations around brain protection.
Public engagement project to improve communication
between parents of newborn babies with acute brain
injuries and the professionals caring for them (NJ
Robertson, J Hassell, M Dinan, K Gray).
Marlow, N., Ourselin, S. (2015). Longitudinal measurement of
the developing grey matter in preterm subjects using multimodal MRI. NeuroImage, 111 580-589.
Women’s Cancer
Usha
Menon
John
Timms
Gynaecological
Cancer Research
Centre (GCRC)
Cancer
Proteomics
Group
Translational Research Centre.
Working For Women,
Working Against Cancer
Anne
Lanceley
Patient Care
Research Group
The Department of Women’s Cancer
has four research groups: (i) the
Gynaecological Cancer Research
Centre (GCRC - led by Usha Menon);
(ii) the Women’s Cancer Translational
Research Centre (led by Martin
Widschwendter); (iii) the Cancer
Proteomics Group (led by John Timms)
and (iv) the Patient Care Research
Group (led by Anne Lanceley).
Each group brings its own distinctive
approach and perspective to the risk,
detection, prevention and treatment of
women’s cancers.
For more details go to the Women’s Cancer website
www.ucl.ac.uk/instituteforwomenshealth/womens-cancer
UK Collaborative Trial
on Ovarian Cancer
Screening (UKCTOCS)
first mortality results
Studies involving trial biobanks
Menon U, Jacobs I, Parmar M, Skates S, Campbell S,
Gynaecological Cancer Research Centre
Fallowfield F, McGuire AJ
(iv) Surgical trends in endometrial cancer treatment with a
key focus on trends in pelvic lymphadenectomy in the
UKCTOCS cohort.
A number of nested case control studies involving the trial
The team presented the initial mortality results at a public
biobanks were undertaken both as part of academic and
meeting on 17th December 2015, held at the Royal College of
industry collaborations, with those led by the GCRC group
Obstetricians and Gynaecologists in London and published
including testing and validation of new serial biomarker
simultaneously online in The Lancet. The trial differs from
algorithms and biomarker panels in UKCTOCS sample sets.
those conducted previously by incorporating a serial biomarker
algorithm (ROCA) in one (multimodal screening) of the
of 15% and 11% on comparing each of the two screening
EC H2020 FORECEE (Female
cancer prediction using
cervical omics to individualise
screening and prevention)
arms with the control group which was not significant using the
Jones A, Reisel D, Teschendorff AE, Ghazali S, Knapp S, Evans
primary Cox analysis. However, there was evidence for the first
I, Bennett J, Widschwendter M
screening strategies tested during the trial. In the multimodal
but not the ultrasound group, there was a larger proportion
of early stage ovarian/peritoneal cancers than control (no
screening). There was a reduction in ovarian cancer mortality
time that screening had resulted in a significant reduction in
ovarian cancer deaths (22%) in the multimodal group using the
weight log rank analysis. There was also a significant reduction
in deaths in the multimodal arm when women who had ovarian
cancer at recruitment (prevalent cases) were excluded. Despite
the encouraging findings that 1 in 5 (20%) ovarian cancer
deaths may be prevented if women undergo annual multimodal
screening, this needs to be confirmed on further follow up.
The Endometrial Cancer Cohort
within UKCTOCS
FORECEE is a clinical research programme funded by the
European Commission and The Eve Appeal (www.eveappeal.
org) and potentially could radically change preventative
healthcare globally, by focusing on individual risk predictors for
cancer that are hormone-associated and specific to women
(breast, ovarian, endometrial and cervical cancers). These
represent more than 47% of all cancers in women and amongst
them are cancers with a 5-year survival rate of less than 40%.
Martin Widschwendter is the UCL Principal Investigator and
Coordinator of the FORECEE Consortium comprising of 13
partners. The programme seeks to introduce an augmented
screening process using cells
Gynaecological Cancer Research Centre
collected in the cervical smear
Over 1600 women in UKCTOCS have been identified to have
test to predict the development of
developed endometrial cancer in the course of the trial. A
3 other women-only cancers by
huge effort was made in 2015 to retrieve medical notes and
tracking each individual woman’s
characterise these cancers. This has contributed to a number
risk factors and how her own
of studies, key among them being:
body responds to them. This is
(i) Quality of life in endometrial cancer survivors – Over 1000
innovative research and based
on the outcomes over the next 4
of these women were sent quality of life questionnaires.
Preliminary findings were presented at the European Society
years, the FORECEE team seeks to translate the outputs into
of Gynaecological Oncology annual meeting in Lisbon
recommendations for new clinical pathways for screening and
in September 2015 and the final analysis and drafting of
prevention of the 3 key hormone-associated female cancers
manuscript is underway.
(ovarian, womb, breast) for implementation nationally and
(ii)Costs and survival over five years following endometrial
internationally.
cancer diagnosis in collaboration with Mark Pennington and
Rosa Legood from London School of Hygiene & Tropical
Medicine (LSHTM) is currently in press.
(iii)The lifetime effects, costs and cost effectiveness of
endometrial cancer screening in collaboration with LSHTM.
BRCA PROTECT Research Clinic Mainstreamed Genetic Testing
Reisel D, Rosenthal A, Ghazali S, Widschwendter M.
Lanceley A, Rahman B, Side L, Kristeleit R
A new research clinic
Ovarian cancer is the
funded by The Eve
fifth most common
Appeal was launched
cancer amongst
in November 2015
women in the UK,
at University College
and accounts for
London Hospital
more deaths than
to facilitate sample
all other gynaecological cancers combined. Mutations in the
collection for the FORECEE programme, amongst others.
cancer susceptibility genes BRCA1 and BRCA2 are associated
The BRCA Protect Research Clinic will recruit women from a
with ovarian cancer. To date BRCA genetic testing has been
variety of backgrounds including women with no known risk of
the domain of clinical genetics services. Moving genetics
cancer and those who are at higher risk as they have a BRCA1/
into mainstream medicine is a key strategy in response to the
BRCA2 mutation or Lynch syndrome. The clinic is also open
increasing demand for genetic testing in conditions such as
to mothers, sisters, daughters and female cousins of women
ovarian cancer, where there is a substantial element of inherited
carrying gene mutations but who have tested negative for that
disease. Ovarian cancer patients and their families will benefit
mutation. Women provide a blood sample, cervical smear and
from knowledge of their BRCA genetic status. It can guide
cheek swab as well as providing detailed clinical data. In total,
treatment options for ovarian cancer and prevent new ovarian
across 6 clinical sites in the FORECEE project, samples and
cancers in the population by identifying relatives at risk and
associated data from more than 6,000 women are needed.
providing them with options to reduce their risk of developing
Their contribution is integral to the project and vital if we are
cancer in the future. Despite the benefits and increasing
to understand who is at risk from women’s cancers (see www.
availability of mainstreamed genetic testing, the impact of
brcaprotect.org for further information).
moving testing from the specialised service of clinical genetics
and genetic counselling to the acute oncology setting remains
Discovery of Biomarkers for
the Early Detection of Cancer
unknown. This study will explore the psychosocial impact of
mainstreamed BRCA testing for women with ovarian cancer
using a mixed-methods approach.
Timms J, Cuenco J, Whitwell H, Kazarian A, Irungu S, Blyuss, O
The early detection of cancer is critical to
reducing mortality. The identification and
development of blood-borne biomarkers
may hold the key. 2015 has seen the group
Conversation Analysis
of CALM Therapy
Lanceley A, Shaw C, Davis S, Gessler S, Chrysikou V, Rodin G
progressing several projects in ovarian,
Managing Cancer and Living
breast and pancreaticobiliary cancers
Meaningfully (CALM) is a therapeutic
towards the validation of multi-marker models that improve on
approach, uniquely designed for
the performance of single marker tests. Research is focused
individuals and their partners facing
on the use of pre-diagnosis samples sourced from UKCTOCS
advanced cancer that is intended
following discovery efforts using a variety of proteomic
to alleviate distress and to promote
technologies. Novel methods of combining markers serially
psychological growth. With our
and using network approaches that consider all measurements
international collaborators we have completed our first study
have been tested within the PROMISE (Predicting Risk of
which demonstrates how talk about end of life occurs in the
Ovarian Malignancies,
first session of therapy, typically in response to nonspecific
Improved Screening
open questions by the therapist. The emergence of these
and Early detection)
concerns may occur so early in the therapy because of the
and Pancreatic Cancer
urgent and felt need of patients to raise such issues, and the
UK programmes,
reflective space created by the therapy. The study is part of a
whilst markers for
wider research programme designed to systematically examine
prognostication in pre-
the therapeutic approach of CALM with results that are
clinical breast cancer
transferrable to wider therapeutic contexts where patients face
have been developed.
the end of their life.
Highlights
Meisel, S.F., Pashayan, N., Rahman, B., Side, L., Fraser, L.,
Martin Widschwendter was nominted for a FRCOG (Fellows
frequency of mammography screening on the basis of genetic
ad eundem) of the The Royal College of Obstetricians and
Gynaecologists (RCOG) in 2015 and received an invitation
from RCOG to become a FRCOG in February 2016.
Usha Menon gave the Keynote Lecture at AACR Advances in
Gessler, S., Lanceley, A., ...Wardle, J. (2015). Adjusting the
risk: Attitudes among women in the UK. Breast, 24 (3), 237-241.
Menon, U., Ryan, A., Kalsi, J., Gentry-Maharaj, A., Dawnay,
A., Habib, M. Apostolidou, S., ...Burnell, M., Davies, S.K.,
…Jacobs, I. (2015). Risk algorithm using serial biomarker
Ovarian Cancer Research: Exploiting Vulnerabilities meeting
measurements doubles the number of screen-detected cancers
on ”Ovarian cancer screening” on 19th October 2015 in
compared with a single-threshold rule in the United Kingdom
Florida, USA.
Collaborative Trial of Ovarian Cancer Screening. Journal of
Aleksandra Gentry-Maharaj gave the Keynote Lecture at
Clinical Oncology, 33 (18), 2062-2071.
the 2nd Sino-European Conference on Immune Biomarkers
Teschendorff, A.E., Yang, Z., Wong, A., Pipinikas, C.P., Jiao,
for Personalized Medicine in Oncology, Fudan University
Y., Jones, A., ...Widschwendter, M. (2015). Correlation of
Shanghai Cancer Center on ”Population Screening and Early
Smoking-Associated DNA Methylation Changes in Buccal Cells
Detection of Ovarian Cancer Using CA125” on 13th November
With DNA Methylation Changes in Epithelial Cancer.. JAMA
2015 in Shanghai, China.
oncology, 1 (4), 476-485.
Rema Iyer passed her MD (Surgical Outcomes in
Gynaecological Oncology) viva in November 2015.
John Timms was promoted to Reader in Cancer Proteomics.
Dimitrios Koutoukidis participated in a workshop organised
by the Womb Cancer Alliance in the University of Manchester
in December 2015. The workshop aimed to set the top
Thomas, D.S., Fourkala, E.O., Apostolidou, S., Gunu, R.,
Ryan, A., Jacobs, I., Menon, U., …Gentry-Maharaj, A.,
...Timms, J.F. (2015). Evaluation of serum CEA, CYFRA21-1
and CA125 for the early detection of colorectal cancer using
longitudinal preclinical samples. British Journal of Cancer, 113
(2), 268-274.
20 priorities in research on endometrial cancer based on
Widschwendter, M., Burnell, M., Fraser, L., Rosenthal, A.N.,
extensive feedback from patients, relatives, health care
Philpott, S., Reisel, D., Jacobs, I., Menon, U., ...Dougall, W.C.
professionals, and researchers. Dimitrios’ contribution was to
(2015). Osteoprotegerin (OPG), The Endogenous Inhibitor of
successfully advocate research on the link between healthy
Receptor Activator of NF-κB Ligand (RANKL), is Dysregulated in
lifestyle and endometrial cancer survivorship to be placed
BRCA Mutation Carriers. EBioMedicine, 2 (10), 1331-1339.
among the top 10 research priorities.
Coming up
The results of the more intensive ROCA-driven screening
Jacobs, I.J., Menon, U., Ryan, A., Gentry-Maharaj, A.,
programme offered to high risk women in the second
Burnell, M., Kalsi, J.K., …Apostolidou, S., …Crump,
phase of UK Familial Ovarian Cancer Screening Study are
D.N., …Davies, S.K., …Gunu, R., …Karpinskyj, C., …b …
due to be published in the Spring of 2016.
Moult, T., …Taylor, J., …Widschwendter, M., ...Skates, S.J.
(2015). Ovarian cancer screening and mortality in the UK
Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a
randomised controlled trial. The Lancet, epub.
Jenkinson, C., Elliott, V., Evans, A., Oldfield, L., Jenkins, R.E.,
O’Brien, D.P., Apostolidou, S., Gentry-Maharaj, A., Fourkala,
E.O., Jacobs, I.J., Menon, U., …Timms, J.F., ...Costello,
E. (2015). Decreased serum thrombospondin-1 levels in
pancreatic cancer patients up to 24 months prior to clinical
In Cancer Proteomics, validation of the developed
biomarker models is planned for 2016 along with grant
applications to develop the novel network analysis
biomarker approach.
The EC FP7 EpiFemCare (EPIgenetics for FEMale
personalised cancer CARE) programme will be completed
by the end of April 2016. Currently a large number of
papers are being produced for publication in 2016.
diagnosis: association with diabetes mellitus. Clinical cancer
research: an official journal of the American Association for
Cancer Research, epub.
Koutoukidis DA, Knobf T, Lanceley A. (2015) Obesity,
Diet, Physical Activity and Health-Related Quality of Life in
Endometrial Cancer Survivors: A Systematic Review. Nutrition
Reviews, 73(6), 399-408.
Current External
Appointments
Grant giving bodies
Specialist societies committees
Peter Brocklehurst is:
Anne Lanceley is a member of the NCRI Psychosocial
• Chair of the MRC/NIHR Methodology Research Programme
panel.
• Chair of the NIHR Health Technology Assessment Maternal,
Neonatal and Child Health panel.
Editors of journal
Aleksandra Gentry-Maharaj is Section Editor of BMC
Women’s Health.
Martin Widschwendter is:
• Founding Editorial Board member for the American Journal
of Clinical and Experimental Obstetrics and Gynecology,
• Senior Editor of the International Journal of Gynecological
Cancer (IJGC).
Nikki Robertson is a member of the Editorial Board for
Neonatology.
Oncology and Survivorship Clinical Studies Group.
Gwyneth Lewis is:
• a member of Population Council Action of pre-eclampsia,
• a member of the Royal College of Obstetricians and
Gynaecologists Global Advisory Board,
• a member of the United Nations Population Fund/UNICEF/
World Health Organisation for Europe; Regional committee
for maternal, newborn, adolescent and reproductive health
for Southern Europe, the Balkans and Central Asia.
John Timms is:
• a member of the Steering Committee of the London
Biological Mass Spectrometry Discussion Group,
• a board member and Secretary of the British Society for
Proteome Research.
Judith Stephenson is:
• Chair of the National Clinical Studies Group for Sexual &
Reproductive Health.
• a trustee of the Margaret Pyke & Population Sustainability
Network Trust.
Melanie Davies is the National Institute for Health and Care
Excellence (NICE) Clinical Director for Women and Children’s
Health.
Pascale Guillot is President of the International Fetal
Transplantation and Immunology Society (IFETIS).
Usha Menon is co-Chair of the International Cancer
Benchmarking Partnership, Module 4.
Miscellaneous
Anne Lanceley is Clinical Supervisor at St. Joseph’s Hospice,
London.
Donald Peebles is a member of the Complex Obstetrics
Clinical Reference Group.
Gwyneth Lewis is:
• a board member and a trustee of Medical Aid Films,
• a board member and a trustee of Merck for Mothers global
advisory board,
• Director and a board member of Hands on for Mothers and
Babies charity.
• an expert advisor of the Pre-empt programme: Preeclampsia and eclampsia monitoring, prevention and
treatment sponsored by the Bill and Melinda Gates
foundation.
John Timms is a member of the Scientific Advisory Board of
the CRUK-CRT-Abcodia Early Diagnosis Consortium.
Martin Widschwendter is:
• a member of the Medical Advisory Board for BRCA
Umbrella,
• European Commission Expert Reviewer for the Horizon
Pascale Guillot is:
• a member of the Medical Advisory Committee, Sparks, the
children’s medical research charity,
• a trustee of Tommy’s Charity.
• the UCL lead for Fetal Medicine, Rare Disease Paediatric
domain in the 100,000 Genomes Project, part of the
Genomics England Clinical Interpretation Partnership.
Peter Brocklehurst is:
• a member of the Health Research Authority, Collaboration
and Development Steering Group,
• Chair of the UK Clinical Research Collaboration Regulatory
and Governance Forum,
• a trustee of The EGA Hospital Charity,
• a trustee of Hands on for Mothers and Babies charity,
• a trustee of Wellbeing of Women charity.
Ratna Chatterjee is a visiting Professor and Consultant in
Medicine and genetics in Youjiang University, China.
Rekha Bajoria is a visiting Professor and Consultant in
Medicine and genetics in Youjiang University, China.
Usha Menon is Honorary Senior Consultant at the Tata
Medical Centre, Kolkata, India.
2020 Framework Programme,
• FRCOG (Fellows ad eundem) of The Royal College of
Obstetricians and Gynaecologists,
• a research lead of Gynaecological Oncology for London
Cancer,
• an scientific adviser to The Eve Appeal.
Neil Marlow is:
• a board member of the NHS England Safe Sustainable
Staffing Review - Children and Young People’s Work
Stream,
• a member of the Executive Board of the European
Foundation for the Care of Newborn Infants,
• a member of the International Neonatal Consortium Seizure
working group (Critical Path Inc.),
• an expert adviser to the NICE Guideline Committees on
Long term follow up of preterm infants and Child Abuse
and Protection,
• Chair of the Independent Advisory Group for the Each Baby
Counts Programme (RCOG),
• Chair of the NHS England Neonatal Critical Care Clinical
Reference Group,
• Chair of the Study Steering Group for the DRIFT10 study at
the University of Bristol.
Publications
1.
2.
3.
Abbott, D.S., Hezelgrave, N.L., Seed, P.T., Norman, J.E.,
Fibronectin to Predict Preterm Birth in Asymptomatic Women
of post mortem MRI for abdominal abnormalities in foetuses
at High Risk. Obstetrics and Gynecology, 125 (5), 1168-1176.
and children. European Journal of Radiology, 84 (3), 474-
doi:10.1097/AOG.0000000000000754
481. doi:10.1016/j.ejrad.2014.11.030
Abu-Hayyeh, S., Ovadia, C., Lieu, T., Jensen, D.D., Cham-
6.
Charles-Edwards, G., Deierl, A., … Edwards, A.D. (2015). Mod-
mechanistic potential of progesterone sulfates in intrahepatic
erate hypothermia within 6 h of birth plus inhaled xenon versus
cholestasis of pregnancy and pruritus gravidarum. Hepatology,
moderate hypothermia alone after birth asphyxia (TOBY-Xe): a
doi:10.1002/hep.28265
proof-of-concept, open-label, randomised controlled trial. Lan-
Ahmed, S.F., Achermann, J.C., Arlt, W., Balen, A., Conway,
cet Neurology, epub. doi:10.1016/S1474-4422(15)00347-6
8.
11. Bailey, J.V., Webster, R., Hunter, R., Freemantle, N., Rait, G.,
UK guidance on the initial evaluation of an infant or an adoles-
Michie, S., ...Stephenson, J. (2015). The Men’s Safer Sex
cent with a suspected disorder of sex development (Revised
(MeNSS) trial: Protocol for a pilot randomised controlled trial
2015). Clinical Endocrinology, doi:10.1111/cen.12857
of an interactive digital intervention to increase condom use in
Akintomide, H., Brima, N., Sewell, R.D.E., Stephenson, J.M.
men. BMJ Open, 5 (2), doi:10.1136/bmjopen-2014-007552
12. Bailey, K., Ryan, A., Apostolidou, S., Fourkala, E., Burnell, M.,
pain during intrauterine device insertion. European Journal of
Gentry-Maharaj, A., ...Pikhart, H. (2015). Socioeconomic indica-
Contraception and Reproductive Health Care, 20 (4), 319-326.
tors of health inequalities and female mortality: A nested cohort
doi:10.3109/13625187.2015.1031885
study within the United Kingdom Collaborative Trial of Ovarian
Alonso-Alconada, D., Broad, K.D., Bainbridge, A., Chan-
Cancer Screening (UKCTOCS). BMC Public Health, 15 (253),
drasekaran, M., Faulkner, S.D., Kerenyi, Á., ...Robertson, N.J.
doi:10.1186/s12889-015-1609-5
(2015). Brain cell death is reduced with cooling by 3.5°C to
13. Bailey, S.R., Field, N., Townsend, C.L., Rodger, A.J., Brock-
5°C but increased with cooling by 8.5°C in a piglet asphyx-
lehurst, P. (2015). Antibiotic prophylaxis for women un-
ia model. Stroke, 46 (1), 275-278. doi:10.1161/STROKEA-
dergoing caesarean section and infant health. BJOG: An
HA.114.007330
International Journal of Obstetrics and Gynaecology, epub.
Amankwah, E.K., Lin, H.Y., Tyrer, J.P., Lawrenson, K., Dennis,
J., Chornokur, G., ...Bruinsma, F. (2015). Epithelial-Mesen-
7.
10. Azzopardi, D., Robertson, N.J., Bainbridge, A., Cady, E.,
bers, J., Dixon, P.H., ...Kremer, A.E. (2015). Prognostic and
(2015). Patients experiences and providers observations on
5.
Arthurs, O.J., Thayyil, S., Owens, C.M., Olsen, O.E., Wade,
A., Addison, S., …Sebire, N.J. (2015). Diagnostic accuracy
G., Edwards, Z., ...Krone, N. (2015). Society for Endocrinology
4.
9.
David, A.L., Bennett, P.R., ...Carter, J. (2015). Quantitative Fetal
doi:10.1111/1471-0528.13701
14. Banerji, C.R.S., Severini, S., Caldas, C., Teschendorff, A.E.
chymal Transition (EMT) Gene Variants and Epithelial Ovarian
(2015). Intra-Tumour Signalling Entropy Determines Clinical
Cancer (EOC) Risk. Genetic Epidemiology, 39 (8), 689-697.
Outcome in Breast and Lung Cancer. PLoS Computational
doi:10.1002/gepi.21921
Biology, 11 (3). doi:10.1371/journal.pcbi.1004115
Arthurs, O.J., Guy, A., Thayyil, S., Wade, A., Jones, R., Norman,
15. Barrett, G., Shawe, J., Howden, B., Patel, D., Ojukwu, O.,
W., ...Chong, W.K. (2015). Comparison of diagnostic perfor-
Pandya, P., Stephenson, J. (2015). Why do women invest in
mance for perinatal and paediatric post-mortem imaging: CT
pre-pregnancy health and care? A qualitative investigation with
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UCL EGA
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2015 Annual Report

2015 Annual Report - Institute for Women`s Health

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