Amyotrophic Lateral Sclerosis (Lou Gehrig`s Disease)
Transcription
Amyotrophic Lateral Sclerosis (Lou Gehrig`s Disease)
Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) ALS What is ALS? ALS is a form of motor neuron disease caused by the degeneration of neurons located in the ventral horn of the spinal cord and the cortical neurons that provide their afferent input. ALS The disorder is characterized by rapidly progressive weakness, muscle atrophy and fasciculations, spasticity, dysarthria, dysphagia, and respiratory compromise. Sensory function generally is spared, as is autonomic, and oculomotor activity. ALS is a progressive, fatal, neurodegenerative disease with most affected patients dying of respiratory compromise and pneumonia after 2 to 3 years; although occasional individuals have a more indolent course and survive for many years. Symptoms The earliest symptoms of ALS are typically obvious weakness and/or muscle atrophy. Other presenting symptoms include muscle twitching, cramping, or stiffness of affected muscles; muscle weakness affecting an arm or a leg; and/or slurred and nasal speech. To be diagnosed with ALS, patients must have signs and symptoms of both upper and lower motor neuron damage that cannot be attributed to other causes. ALS The very high presence of the disease among Italian soccer players, more than five times higher than normally expected, has raised the concern of a possible link between the disease and the use of pesticides on the soccer fields. Conclusion For patients without a family history of the disease, which includes 95% of cases, there is no known cause for ALS. No test can provide a definite diagnosis of ALS, although the presence of upper and lower motor neuron signs in a single limb is strongly suggestive. Instead, the diagnosis of ALS is primarily based on the symptoms and signs the physician observes in the patient and a series of tests to rule out other diseases.