Curriculum 2015/16 - Medizinische Hochschule Hannover
Transcription
Curriculum 2015/16 - Medizinische Hochschule Hannover
Hannover Medical School Hannover Biomedical Research School Curriculum MD/PhD Program “Molecular Medicine” PhD Programs “Infection Biology” and “DEWIN: Dynamics of Host-Pathogen Interactions” PhD Program “Regenerative Sciences” PhD Program “Auditory Sciences” PhD Program “Epidemiology” Marie Curie Initial Training Network ITN-TECAS: “Tissue Engineering for Cardiovascular Surgery” Winter and Summer Semester 2015/2016 2 Hannover Medical School Hannover Biomedical Research School Curriculum MD/PhD Program “Molecular Medicine” PhD Programs “Infection Biology” and “DEWIN: Dynamics of Host-Pathogen Interactions” PhD Program “Regenerative Sciences” PhD Program “Auditory Sciences” PhD Program “Epidemiology” Marie Curie Initial Training Network ITN-TECAS: “Tissue Engineering for Cardiovascular Surgery” Winter and Summer Semester 2015/2016 www.mh-hannover.de/hbrs.html 3 PhD Curriculum Hannover Medical School Academic Year Winter Semester 2015/2016 Start: October 12th, 2015 (Opening ceremony October 19th) End: February 26th, 2016 MD/PhD “Molecular Medicine” intermediate examination: February 26th, 2016 (students organize date) from January 15th to PhD “Infection Biology” intermediate examination: March 16th, 2016 PhD “Regenerative Sciences” intermediate examination: by March 31st, 2016 PhD “Epidemiology” and PhD “Auditory Sciences” intermediate examination: To be decided on an individual basis, depending also on status of PhD thesis Summer Semester 2016 Start: April 4th, 2016 End: July 8th, 2016 4 Organization of Hannover Biomedical Research School Members of the International Advisory Board: Prof. Dr. Nathalie Cartier (INSERM U986 MIRCen CEA, Fontenay aux Roses, France) Prof. Michael Carroll (Harvard Medical School, Childrens Hospital, Boston, USA) Prof. Joachim R. Kalden (University of Erlangen, Germany) Prof. Dr. Steve Keyse (University of Dundee, UK) Prof. Dr. Hans-Gustaf Ljunggren (Karolinska Institute, Stockholm, Sweden) Prof. Dr. Seppo Meri (University of Helsinki, Finland) Prof. Dr. Stanislas Pol (Département des maladies du foie Cochin, University Hospital Paris, France) 5 Dean of the HBRS and chairman of MD/PhD program “Molecular Medicine”: Reinhold E. Schmidt, MD Professor of Medicine, Immunology and Rheumatology Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected] Tel.: 0049-511-532-6656 Fax: 0049-511-532-9067 Coordination of HBRS and MD/PhD program “Molecular Medicine”: Dr. Susanne Kruse and Birgit Müller HBRS Office of the MHH Tel.: 0049-511-532-6011 Präsidalamt, OE 9117 Fax: 0049-511-532-2611 Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected]; [email protected] Web: www.mh-hannover.de/md-phd.html ------------------------------------------------------------------------------------Chairman of PhD programs “Infection Biology” and “DEWIN”: Prof. Dr. Reinhold Förster Tel.: 0049-511-532-9721 Institute of Immunology Fax: 0049-511-532-9722 Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected] Coordination of PhD programs “Infection Biology” and “DEWIN”: Dr. Sabine Johann and Simone Zimmer Tel.: 0049-511-532-9742 Zentrum für Infektionsbiologie – ZIB Fax: 0049-511-532-9722 Institut für Immunologie, OE 5240 Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected] Web: www.mh-hannover.de/zib.html 6 Chairman of PhD program “Regenerative Sciences”: Prof. Dr. Ulrich Martin Tel.: 0049-511-532-8821 LEBAO Fax: 0049-511-532-8819 Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected] Coordination of PhD program “Regenerative Sciences”: Dr. Daniela Pelz Tel.: 0049-511-532-5206 Steffi Gomm Tel.: 0049-511-532-5202 „REBIRTH“, OE 8880 Fax: 0049-511-532-5205 Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected] Web: www.rebirth-hannover.de/en/phd-program.html ------------------------------------------------------------------------------------Chairman of PhD program “Auditory Sciences”: Prof. Dr. Andrej Kral Institut für AudioNeurotechnologie (VIANNA) & Abt. für experimentelle Otologie, HNO-Klinik Medizinische Hochschule Hannover Feodor-Lynen Str. 35 D-30625 Hannover E-mail: [email protected] Tel: 0049-511-532-7272 Fax: 0049-511-532-7274 Coordination of PhD program “Auditory Sciences”: Dr. Odett Kaiser Tel.: 0049-511-532-7234 HNO Clinics, OE 6500 Medizinische Hochschule Hannover Carl-Neuberg Str. 1 D- 30625 Hannover E-Mail: [email protected] ------------------------------------------------------------------------------------Chairman of PhD program “Epidemiology”: Prof. Dr. Gérard Krause Tel: 0049-531-6181-3101 Head of Department of Epidemiology and Professor for Infectious Diesease Epidemiology at the Medical University Hannover Helmholtz Centre for Infection Research Inhoffenstr. 7 D-38124 Braunschweig E-mail: [email protected] 7 Coordination of PhD program “Epidemiology”: Dr. Stefanie Castell & Dr. Jördis Ott Tel.: 0049-531-6181-3115 Helmholtz Centre for Infection Research Tel: 0049-531-6181-3104 Department of Epidemiology Inhoffenstr. 7 D- 38124 Braunschweig E-Mail: [email protected]; [email protected]; [email protected] Web: http://www.helmholtz-hzi.de/de/karriere/phd_studiengang_epidemiologie/ziele/ -------------------------------------------------------------------------------------Members of the MD/PhD program “Molecular Medicine” Commission: Prof. Dr. Reinhold E. Schmidt (Chairman) Prof. Dr. Georg Behrens Prof. Dr. Mathias Gaestel Prof. Dr. Axel Schambach Alexandra Ingendoh Natalie Weber Prof. Dr. Thomas Thum (Vice Chairman) Prof. Dr. Armin Braun Prof. Dr. Dietmar Manstein Prof. Dr. Siegfried Weiss Katharina Lobschat NN Contact/coordination: Dr. Susanne Kruse and Birgit Müller, Medizinische Hochschule Hannover, PhD Office, OE 9117, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-9844; Fax. -2611; [email protected]; [email protected] Members of the PhD programs “Infection Biology” and “DEWIN” Commission: Prof. Dr. Reinhold Förster (Chairman) Prof. Dr. Susanne Häußler Dr. Matthias Lochner Prof. Dr. Reinhold E. Schmidt Prof. Dr. Sebastian Suerbaum (Vice Chairman) Bettina Buchmann Dr. Günter Bernhardt Prof. Dr. Georg Herrler Prof. Dr. Thomas Pietschmann Prof. Dr. Thomas F. Schulz Prof. Dr. Peter Valentin-Weigand Brenda Raud Contact/coordination: Dr. Sabine Johann and Simone Zimmer, Medizinische Hochschule Hannover. ZIB at Institute of Immunology, OE 5240, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-9742; Fax. -9722; [email protected] Members of the PhD program “Regenerative Sciences” Commission: Prof. Dr. Ulrich Martin (Chairman) Prof. Dr. Tobias Cantz Prof. Dr. Birgit Glasmacher Prof. Dr. Axel Schambach, PhD Dr. Gerald Dräger Ralf Haller Janika Viereck Karsten Cirksena Prof. Dr. Renata Stripecke (Vice Chairwoman) Prof. Dr. Boris Chichkov Prof. Dr. Heiner Niemann Prof. Dr. Dagmar Wirth PD Dr. Ina Gruh Christina Müller Hanna Möller Contact/coordination: Dr. Daniela Pelz, Steffi Gomm, Medizinische Hochschule Hannover, REBIRTH Office, OE 8880, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-5206 / -5202; Fax. -5205, [email protected] 8 Members of the PhD program “Auditory Sciences” Commission: Prof. Dr. Andrej Kral (Chairman) Prof. Dr. Andreas Büchner Prof. Dr. Holger Blume Prof. Dr. Lili Geworski (Vice Chairwoman) Christoph Kantzke Advisory: Dr. V. Hamacher, head, Advanced Bionics GmbH ERC Prof. Dr. Thomas Lenarz Prof. Dr. Peter Behrens Prof. Dr. Reinhard Dengler PD Dr. Athanasia Warneke Contact/coordination: Dr. Odett Kaiser, Medizinische Hochschule Hannover, OE 6500, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-7234; [email protected] Members of the PhD program “Epidemiology” Commission: Prof. Dr. Gérard Krause (chairman) Prof. Dr. Rafael Mikolajczyk Prof. Dr. Marie-Luise Dierks Prof. Dr. Armin Koch Prof. Dr. Thomas Pietschmann (guest) Prof. Dr. Reinhold Schmidt (guest) Dr. Stefanie Castell & Dr. Jördis Ott (coordinators) Nicole Rübsamen, Mahrrouz Hoodgarzadeh (students) Programme Coordination: Dr. Stefanie Castell & Dr. Jördis Ott Helmholtz Centre for Infection Research, Department of Epidemiology, Inhoffenstr. 7, D- 38124 Braunschweig; [email protected]; [email protected] Programme Assistance: Helga Brink; Helmholtz Centre for Infection Research, Department of Epidemiology, Inhoffenstr. 7, D- 38124 Braunschweig; phd-epidemiology@helmholtz-hzi; phone: +49-531-6181-3105 Marie Curie Initial Training Network “ITN-TECAS: Tissue Engineering for Cardiovascular Surgery” Dr. Sotiris Korossis (Chairman) Department of Cardiac, Thoracic, Transplantation and Vascular Surgery Email: [email protected] Contact/coordination: Ms Eirini Chatzigeorgiou, TECAS-ITN Research Manager, Lower Saxony Centre for Biomedical Engineering Implant Research and Development, Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Feodor-Lynen-Straße 31, Hannover, 30625, Germany, Tel: +49 511 532 7798, Email: [email protected] Members of the Doctorate Training Programme ITN-TECAS Committee: Dr. Sotiris Korossis (Chairman) Prof. Dr. Axel Haverich (Vice Chairman) Prof. Dr. Christopher Baum Prof. Dr. Reinhold E. Schmidt Prof. Dr. Gino Gerosa (University of Padua) Prof. Dr. Stefan Jockenhoevel (University Hospital Aachen) Prof. Frank Baaijens (Eindhoven University of Technology) Prof. Demosthenes Mavrilas (University of Patras) Dr. Michael Harder (Corlife GbR) 9 Content: Page Obligatory seminars for PhD programs ......................................................................... 14 1st Semester MD/PhD „Molecular Medicine“ ............................................................... 14 - in-depth seminars for medical students ...................................................................... 17 - in-depth seminars for life scientists............................................................................. 17 2nd Semester MD/PhD „Molecular Medicine“ ............................................................... 19 3rd Semester MD/PhD “Molecular Medicine” .......................................................... 22 - Focus Immunology ........................................................................................................ 22 - Focus Genetics and Cell Biology ................................................................................. 26 4th Semester MD/PhD “Molecular Medicine” .......................................................... 28 - Focus Infection and Immunity ...................................................................................... 28 - Focus Differentiation and Oncology ............................................................................ 30 1st Semester PhD “Infection Biology / DEWIN”.................................................... 32 2nd Semester PhD “Infection Biology / DEWIN” ................................................... 34 3rd Semester PhD “Infection Biology/ DEWIN”........................................................ 36 4th Semester PhD “Infection Biology/ DEWIN” ........................................................ 38 1st Semester PhD “Regenerative Sciences” ............................................................ 40 2nd Semester PhD “Regenerative Sciences” ........................................................... 43 3rd Semester PhD “Regenerative Sciences” ............................................................ 46 4th Semester PhD “Regenerative Sciences” ............................................................ 48 Additional Offers PhD “Regenerative Sciences” .................................................... 50 PhD program “Auditory Sciences” ........................................................................... 51 PhD program “Epidemiology” ................................................................................... 55 Obligatory program for Research Training Groups [(E)GRKs] .................................... 56 ITN-TECAS ........................................................................................................................ 56 Specific seminars ............................................................................................................ 59 - organized by HBRS........................................................................................................ 59 Optional courses .............................................................................................................. 60 Requirements and Rules ................................................................................................. 61 Map .................................................................................................................................... 67 10 Curriculum MD/PhD “Molecular Medicine” 1st year 2nd sem. 1st sem. Immunology/Stem Cell Biology/ Bacteriology/ Virology Basics in Molecular Medicine (Focus on Methods); Seminar, 2h Cell Biology/ Genetics/ Biochemistry/ Methods Tutorial, 1h In parallel: special in-depth seminars for medical students and students from life sciences, respectively 2nd year 3rd sem. Tutorial for the respective seminar/tutorial series 4th sem. 1. Focus: Immunology or 2. Focus: Genetics & Cell Biology 3. Focus: Infection or 4. Focus: Differentiation & Oncology For all: Seminar, 2h and Tutorial, 1h 3rd year: concentration on individual research projects Structure of the MD/PhD program „Molecular Medicine“ Year 1 Year 2 Year 3 • Sem. + Lect. In basic sciences Monday (4.30 - 6.00 p.m.; 6 cp) • Tutorials Monday; till Christmas separate tutorials for edical students and life scientists (3.15 – 4.15 p.m.; 2 cp) • Complex and clinical system; choice between the foci Immunology, Infection, Oncology and Differentiation, Cell Biology/Genetics, Biochemistry Mondays, Seminar and Tutorial (3.00 – 6.00 p.m.; 8 cp) • 3-year PhD project work (125 cp) • Three presentations in department over three years (10 cp) • Three presentations of manuscripts at the departments Journal Club over three years (3 cp) • Public annual presentation/project report (10 cp) •Talk / presentation at international congress (2 cp) • Project-orientated seminars/courses; including practicals (80 h, 8 cp) • Participation in summer schools / interdisciplinary seminars (e.g. soft skills)/ congress (60 h, 6 cp) Intermediate exam after 18 months cp: credit points PhD thesis and final exam after 3 years 11 Curriculum PhD “Infection Biology” and “DEWIN” 1st Year 1st Semester 2nd Semester Weekly seminars: Immunology/Microbiology/ Virology/Cell Biology Project Reports & Special topic lectures 2nd Year 3rd Semester 4th Semester Presentation of original manuscripts & reviews Project Reports Structure of the PhD Program “Infection Biology“ and “DEWIN” Year 1 • Sem. + Lect. Monday (16.30 - 18.00 hrs; 6 cp) • Journal Club in students own department (15 h) + attendance of 15 scientific lect. At MHH/HZI/ TiHo (such as SFB-Sem. or Immunol. Colloquium; 2 cp) Year 2 Year 3 • Seminar based on reviews and original manuscripts (Monday 16.15 or 16.30 – 18.00) (4 cp) • Presentation of one review and one original manuscript during these seminars (4 cp) • Journal Club in students own department (15 h) + attendance of 15 scientific lect. at MHH/HZI/ TiHo (such as SFB-Sem. or Immunol. Colloquium; 2 cp) • 3-year PhD project work (125 cp) • Public presentations/project reports (i.e. Retreat) (10 cp) • Three presentations in department over three years (10 cp) • Three presentations of manuscripts at the departments Journal Club over three years (3 cp) • Talk / presentation at international congress (2 cp) • Practical courses (80 hours) (10 cp) • Participation in summer schools / interdisciplinary seminars (e.g. soft skills) / congress (20h) (2 cp) cp: credit points Intermediate exam after 18 months PhD thesis and final exam after 3 years 12 Structure of the PhD-Program “Regenerative Sciences” Year 1 Year 2 Year 3 • Seminars + Lectures in basic sciences Thursday (4.15 - 5.45 p.m.) • Seminars + Lectures in basic sciences Thursday (4.15 - 5.45 p.m.) • Tutorials Thursday (3.00 – 4.00 p.m.) • Tutorials Thursday (3.00 – 4.00 p.m.) • • • 3-year PhD project work • • • • Focus on experimental work Three presentations in department within three years (regular attendance) 3 Presentations of manuscripts at the department’s Journal Club within three years (regular participation, i.e. 10 times per year) Public annual presentation/project report (i.e. retreat) Talk/presentation at international congress Project-orientated seminars/courses; including practicals and summer schools (80 h) Participation in interdisciplinary seminars (e.g. soft skills/congresses) (40h) Intermediate exam after 18 months PhD thesis and final exam after 3 years You may replace up to 30 hours of the Thursday seminars and tutorials by the additional offers ”Meet the Investigator” or “Method based seminar” see page 50 13 - three year research project - three project presentations over the three year time period - active participation in Journal Clubs, i.e. presentation of manuscripts or workshop outcomes - active participation in scientific conferences, i.e. poster or oral presentation - annual PhD-Retreats - soft skill courses - program modules (lectures, field work, and courses) Æ total accompanying program of a minimum of 300 hrs. 14 Obligatory MD/PhD ”Molecular Medicine” 1st Semester Note: The curriculum of the first year is more orientated towards basics and methods in the different diciplines. MD/PhD “Molecular Medicine”: There are some alternative in-depth seminars/ tutorials on Mondays for medical students and students from life sciences till Christmas (see pages 17/18) and the respectives tutorial for the seminars. 1.) General Immunology Episode I: The hematopoetic wonderland Monday, 12.10.15 HBRS Opening Ceremony Lecture Hall “R” Monday, 19.10.15 5.00 p.m. What innate immune cells can do for you Monday, 26.10.15 4.30 – 6 p.m. 2 hrs Monday, 02.11.15 4.30 – 6 p.m. 2 hrs Monday, 09.11.15 4.30 – 6 p.m. 2 hrs Monday, 16.11.15 4.30 – 6 p.m. 2 hrs Monday 23.11.15 4.30 – 6 p.m. 2 hrs Andreas Krüger Lecture hall B (building J2) Immo Prinz B-cells and antibody responses Georgios-Leandros Moschovakis Multiple choices: Induction and function of T helper cells 4.30 – 6 p.m. 2 hrs Matthias Lochner Divide and Conquer: Antigen presentation and cytotoxic T cells Georg Behrens 2.) General Bacteriology Introduction to Medical Microbiology: Common themes in bacterial pathogenesis Sebastian Suerbaum 15 Paradigms of Infection Biology: Mycobacteria Monday, 30.11.15 4.30 – 6 p.m. 2 hrs Monday, 07.12.15 4.30 – 6 p.m. 2 hrs Paradigms of Infection Biology: The gastrointestinal Monday, habitat and its microbiota; Helicobacter and Campoylobacter as specific pathogens of the niche 14.12.15 4.30 – 6 p.m. 2 hrs Monday, 04.01.16 4.30 – 6 p.m. 2 hrs Monday 11.01.16 4.30 – 6 p.m. 2 hrs Monday, 18.01.16 4.30 – 6 p.m. 2 hrs Monday, 25.01.16 3.15 – 4.15 p.m. 1 hr Monday, 25.01.16 4.30 – 6 p.m. 2 hrs Monday, 01.02.16 3.15 – 4.15 p.m. 1 hr Monday, 01.02.16 4.30 – 6 p.m. 2 hrs Monday, 08.02.16 3.15 – 4.15 p.m. 1 hr Monday, 08.02.16 4.30 – 6 p.m. 2 hrs Franz Bange Paradigms of Infection Biology: Chlamydia and Listeria Andreas Klos Christine Josenhans Paradigms of Infection Biology: Salmonella Guntram Graßl Metabolism and Virulence Dirk Hofreuter 3.) General Virology Different Viruses and Viral Diseases Anke Kraft Tutorial Kraft (Viral Disease) (HBRS seminar room 1140, J4) Virus Entry and Structural Virology Thomas Krey Tutorial Krey (HCV, Fusion proteins) HBRS seminar room 1140, J4) Virus Assembly, Maturation and Egress Eike Steinmann (TwinCore) Tutorial Steinmann (NOT FLAVIVIRIDAE) (HBRS seminar room 1140, J4) Transcription and Replication of DNA Viruses Jens Bohne 16 Tutorial Bohne (Journal Club, Replication of HIV) Monday, 15.02.16 3.15 – 4.15 p.m. 1 hr Monday, 15.02.16 4.30 – 6 p.m. 2 hrs Monday, 22.02.16 3.15 – 4.15 p.m. 1 hr Monday, 22.02.16 4.30 – 6 p.m. 2 hrs (HBRS seminar room 1140, J4) Transcription and Replication of RNA Viruses Thomas Pietschmann Tutorial Pietschmann (NOT FLAVIVIRIDAE) (HBRS seminar room 1140, J4) Pathogenesis, Host defense and viral interference Abel Viejo-Borbolla Location Hannover Biomedical Research School, Lecture hall B, I 2 17 *only for MD/PhD “Molecular Medicine” medical students: Some more basics in Life Sciences As there are not many medical students this year, we will arrange an individual program for you! Or you visit the tutorials for life scientists or PhD “Infection Biology” Mondays, 3.15 – 4.15 p. m. [Microbiology, Developmental Biology (Kispert), Biochemistry (Kotlyarov), Virology (Verhagen), Genetics (Schubert)] Location ask at PhD office ** only for PhD students from life sciences: Some basics in Medicine/Techniques Opening ceremony, October 19th ONLY for PhD “Molecular Medicine”: Monday, 12.10.15 3.15 - 4.15 p.m. 1 hr No tutorial because of opening ceremony Monday, 19.10.15 Clinical Immunology: pathogenesis of an autoimmune disease (Lupus erythematosus) Monday, 26.10.15 3.15 - 4.15 p.m. 1 hr Monday, 02.11.15 3.15 - 4.15 p.m. 1 hr Monday, 09.11.15 3.15 - 4.15 p.m. 1 hr No tutorial because of Animal course Monday, 16.11.15 Protein tyrosine kinases and human cancer Monday, 23.11.15 3.15 - 4.15 p.m. 1 hr Monday, 30.11.15 3.15 - 4.15 p.m. 1 hr Monday, 07.12.15 3.15 - 4.15 p.m. 1 hr Monday, 14.12.15 3.15 - 4.15 p.m. 1 hr General introduction, lectures, expectations etc.; answering of all last questions, election of class speaker Susanne Kruse Torsten Witte Hematology: pathogenesis of malignant diseases Matthias Eder Gene Technology and Biosafety Ruth Knorr Zhixiong Li Super resolution light microscopy Rudolf Bauerfeind Electron Microscopy Stephanie Groos FACS analysis Roland Jacobs 18 Chip cytometry Monday, 04.01.16 3.15 - 4.15 p.m. 1 hr Monday, 11.01.16 3.15 - 4.15 p.m. 1 hr Monday, 18.01.16 2.15 - 3.15 p.m. 1 hr Christian Hennig Cell Sorting Mathias Ballmaier Is it Allergy? Clinical presentations and diagnostic workups Ulrike Raap Location (level 01) Hannover Biomedical Research School, HBRS seminar room 1140, I 4, 2nd floor 19 2nd Semester Curriculum MD/PhD Molecular Medicine MD/PhD MM: please attend the whole of the seminars and tutorials listed below. 4. ) General Cell Biology Tutorial Borbolla (Neurotropic Viruses) Monday 04.04.16 3.15 – 4.15 p.m. 1 hr Monday 04.04.16 4.30 – 6 p.m. 2 hrs Monday, 11.04.16 3.15 – 4.15 p.m 1 hr Monday 11.04.16 4.30 – 6 p.m. 2 hrs Monday, 18.04.16 3.15 – 4.15 p.m. 1 hr Monday, 18.04.16 4.30 – 6 p.m. 2 hrs Tutorial Stradal Monday, 25.04.16 3.15 – 4.15 p.m. 1 hr Next generation sequencing Monday, 25.04.16 4.30 – 6 p.m. 2 hrs Monday, 02.05.16 3.15 – 4.15 p.m. 1 hr Using genome wide screening methods to identify the Monday, genetic basis of syndromic cancer predisposition 02.05.16 4.30 – 6 p.m. 2 hrs (HBRS seminar room 1140, J4) The cell cycle and its implication in disease Hans J. Hauser Lecture hall B Tutorial Hauser (HBRS seminar room 1140, J4) Intracellular trafficking Melanie Brinkmann Lecture hall B Tutorial Brinkmann (HBRS seminar room 1140, J4) The structure of the cell’s interior Theresia Stradal (HZI) Lecture hall B (Now only for MD/PhD MM) All seminars and tutorials in HBRS seminarroom 5.) Biochemistry and Genetics; methods Robert Geffers (HZI) No tutorial Ruthild Weber 20 Tutorial Weber Monday, 09.05.16 3.15 – 4.15 p.m. 1 hr Strategies to analyse gene function in vivo Monday, 09.05.16 4.30 – 6 p.m. 2 hrs No seminar and tutorial, public holiday! Monday 16.05.16 Tutorial Gossler Monday 23.05.16 3.15 – 4.15 p.m. 1 hr Mass spectrometry and protein analysis Monday 23.05.16 4.30 – 6 p.m. 2 hrs Monday, 30.05.16 3.15 – 4.15 p.m. 1 hr Monday, 30.05.16 4.30 – 6 p.m. 2 hrs Tutorial Tiedje Monday, 06.06.16 3.15 – 4.15 p.m. 1 hr Transcriptomics Monday, 06.06.16 4.30 – 6 p.m. 2 hrs Monday, 13.06.16 3.15 – 4.15 p.m. 1 hr Monday, 13.06.16 4.30 – 6. p.m. 2 hrs Achim Gossler Andreas Pich Tutorial Shot gun and targeted mass spectrometry Pich The complex world of RNA Christopher Tiedje (Mathias Gaestel) Oliver Dittrich-Breiholz Building J3, Level 1, Room 2020 Tutorial Dittrich-Breiholz Building J3, Level 1, Room 2020 Physical Methods in Biochemistry: Spectroscopy, hydrodynamics, structure Ute Curth Building J3, Level 1, Room 2020 21 Tutorial Curth Monday, 20.06.16 3.15 – 4.15 p.m. 1 hr Stem cells Monday, 20.06.16 4.30 – 6. p.m. 2 hrs Tutorial Schambach Monday, 27.06.16 3.15 – 4.15. p.m. 1 hr Techniques of miRNAs and lncRNAs Monday, 27.06.16 4.30 – 6.30 p.m. Jan Fiedler seminar + tutorial (or 2 sessions?) Axel Schambach Location Hannover Biomedical Research School, I 4, 2nd floor, HBRS seminar room 1140 (HBRS seminar room) 2 hrs 22 MD/PhD program “Molecular Medicine” 3rd Semester Note: The curriculum of the second year is more orientated towards research and applied aspects in the different diciplines. Every student has the choice between two major foci each semester. You may vary in the choice of modules between the two foci. Please, choose the ones most appropriate for you and your project! 1. Focus: Immunology 1. Immune cells and organs Regulation and function of NK cells Monday, 12.10.15 3 – 5 p.m. 2 hrs Monday, 12.10.15 5 – 7 p.m. 2 hr Opening ceremony of HBRS Monday, 19.10.15 5 p.m. HS R No seminar Monday 26.10.15 3 – 5 p.m. 2 hrs Tutorial Jacobs Monday 26.10.15 5 - 6 p.m. 1 hr Calcium signaling and autoimmune inflammation (topic 2) Monday, 02.11.15 3 – 5 p.m. 2 hrs Tutorial Berod de Sparwasser Monday, 02.11.15 5 – 6 p.m. 1 hr T and B cell differentiation Monday, 09.11.15 3 – 6 p.m. 3 hrs Fritz Melchers (Berlin/Basel) Seminar+Tutorial Roland Jacobs Metabolic regulation of immune cells Luciana Berod de Sparwasser Georgios Sogkas 2. Autoimmunity Major histocompatibility complex in tolerogenic cell therapies Monday 16.11.15 3 – 5 p.m. 2 hrs Monday 16.11.15 5 – 6 p.m. 2 hr Constanza Figueiredo Tutorial Sogkas 23 Transplantation, Tolerance and Tregs Monday, 23.11.15 3 – 5 p.m. 2 hrs Monday, 23.11.15 5 – 6 p.m. 1 hr Monday, 30.11.15 3 – 5 p.m. 2 hrs Tutorial Hardtke-Wolenski Monday, 30.11.15 5 – 6 p. m. 1 hr Allergic skin diseases Monday 07.12.15 3 – 5 p.m. 2 hrs Tutorial Dijkstra Monday 07.12.15 5 – 6 p.m. 1 hr Neuroimmune interactions in asthma bronchiale Monday, 14.12.15 3 – 5 p.m. 2 hrs Tutorial Werfel Monday, 14.12.15 5 – 6 p.m. 1 hr Studying allergic airway inflammation: of mice and man Monday, 04.01.16 3 – 5 p.m. 2 hrs Tutorial Braun Monday, 04.01.16 5 – 6 p.m. 1 hr Primary Immunodeficiencies in humans – what can they teach us about the immune system? Monday 11.01.16 3 – 5 p.m. 2 hrs Monday 11.01.16 5 – 6 p.m. 1 hr Monday, 18.01.16 3 – 5 p.m. 2 hrs Monday, 18.01.16 5 – 6 p.m. 1 hr Matthias Hardtke-Wolenski Tutorial Figueiredo 3. Allergy and Asthma, Immunological diseases Basophils revisited Dorrit Dijkstra Thomas Werfel Armin Braun (Fraunhofer Institute) Melanie Albrecht / Anna-Maria Dittrich Almut Meyer-Bahlburg Tutorial Albrecht/Dittrich 5. Signaling and therapy Immune Checkpoints as therapeutic target for cancer Engin Gürlevik Tutorial Meyer-Bahlburg 24 Regulation of immune responses by CD45 molecules Monday, 25.01.16 3 – 5 p.m. 2 hrs Reinhard Schwinzer Tutorial Gürlevik Monday, 25.01.16 5 – 6 p.m. 1 hr The complement system and its regulation Monday 01.02.16 3 – 5 p.m. 2 hrs Tutorial Schwinzer Monday 01.02.16 5 – 6 p.m. 1 hr Acute renal failure – mechanisms of disease Monday, 08.02.16 3 – 5 p.m. 2 hrs Tutorial Klos Monday, 08.02.16 5 – 6 p.m. 1 hr Tumor immunity and oncogenic signaling Monday, 15.02.16 3 – 5 p.m. 2 hrs Tutorial Güler Monday, 15.02.16 5 – 6 p.m. 1 hr Tutorial Falk Monday, 22.02.16 5 – 6 p.m. 1 hr Andreas Klos Faikah Güler Christine Falk Location entrance) Building I4, level SO (ground floor), seminar room S1400 (right to the main 25 2. Focus: Genetics and Cell Biology 1. Techniques and diagnostics/therapy Embryonic and somatic cloning in mammals Monday 12.10.15 3 – 5 p.m. 2 hrs No tutorial Monday 12.10.15 Opening ceremony Monday, 19.10.15 5 p.m. HS R Signal-dependent regulation of mRNA translation and non-coding RNAs by RNA-binding proteins Monday, 26.10.15 3 – 5 p.m. 2 hrs Tutorial Niemann Monday, 26.10.15 5 – 6 p.m. 1 hr Molecular mechanisms of vascular aging in health and disease Monday, 02.11.15 3 – 5 p.m. 2 hrs Monday, 02.11.15 5 – 6 p.m. 1 hr Monday 09.11.15 3 – 5 p.m. 2 hrs Tutorial Kiyan Monday 09.11.15 5 – 6 p.m. 2 hrs Molecular mechanisms of heart failure Monday, 16.11.15 3 – 5 p.m. 2 hrs Tutorial Emmrich Monday, 16.11.15 5 – 6 p.m. 1hrs Molecular biology of heart failure Monday, 23.11.15 3 – 5 p.m. 2 hrs Monday, 23.11.15 5 –6 p.m. 1 hr Heiner Niemann Christopher Tiedje (Matthias Gaestel) Yulia Kiyan Tutorial Tiedje 2. Genetics Cell tracing strategies with fluorescent proteins Stephan Emmrich Arash Haghikia Denise Hilfiker Tutorial Haghikia 26 3. Transmembrane Signaling Functions of Syndecans in inflammatory diseases Monday 30.11.15 3 – 5 p.m. 2 hrs Tutorial Hilfiker Monday 30.11.15 5 – 6 p.m. 1 hr Small GTPases as targets of bacterial toxins Monday, 07.12.15 3 – 5 p.m. 2 hrs Tutorial Echtermeyer Monday, 07.12.15 5 – 6 p.m. 1 hr Glycosylation and diseases Monday, 14.12.15 3 – 5 p.m. 2 hrs Tutorial Genth Monday, 14.12.15 5 – 6 p.m. 1 hr Membrane domains Monday 04.01.16 3 – 5 p.m. 2 hrs Monday 04.01.16 5 – 6 p.m. 1 hr Looking closely at the lung and its surfactant system Monday, (refers to topic 1) 11.01.16 3 – 5 p.m. 2 hrs Frank Echtermeyer Harald Genth Hans Bakker Robert Lindner Tutorial Bakker 4. Cell Biology and disease Matthias Ochs / Elena Lopes-Rodriguez Tutorial Lindner Monday, 11.01.16 5 – 6 p.m. 2 hr How molecular motors work Monday, 18.01.16 3 – 5 p.m. 2 hrs Tutorial Ochs / Lopes-Rodriguez Monday, 18.01.16 5 - 6 p.m. 2 hr Pathophysiology of arteriosclerosis Monday 25.01.16 3 – 5 p.m. 2 hrs Tutorial Manstein Monday 25.01.16 5 – 6 p.m. 1 hr Micro RNAs from disease mechanisms to therapeutic approaches Monday, 01.02.16 3 – 5 p.m. 2 hrs Monday, 01.02.16 5 – 6 p.m. 1 hr Dietmar Manstein Daniel Sedding Thomas Thum Tutorial Sedding 27 Genomic Alterations and Cancer Predisposition Monday, 08.02.16 3 – 5 p.m. 2 hrs Tutorial Jan Fiedler Monday, 08.02.16 5 – 6 p.m. 1 hr Stem cells in renal injury Monday, 15.02.16 3 – 5 p.m. 2 hrs Tutorial Steinemann Monday, 15.02.16 5 – 6 p.m. 1 hr Tutorial Schmitt Monday, 22.02.16 5 – 6 p.m. 1 hr Doris Steinemamn Roland Schmitt Location Building I4, 2nd floor (Ebene 1), seminar room 1031 (Master program) 28 MD/PhD program “Molecular Medicine” 4th Semester 3. Focus: Infection and Immunity 1. Innate Immunity; Infection and disease Evolutionary aspects of the Immune System Monday 04.04.16 3 – 5 p.m. 2 hrs No tutorial Monday, 04.04.16 5 – 6 p.m. 1 hr From Virus pathogenesis to viral therapy Monday, 11.04.16 3 – 5 p.m. 2 hrs Tutorial Weiss Monday, 11.04.16 5 – 6 p.m. 1 hr Innate Immunity to Viral Infections Monday, 18.04.16 3 – 5 p.m. 2 hrs Monday, 18.04.16 5 – 6 p.m. 1 hr Acute and chronic bacterial infection of the lung Monday (Location: Experimental Pneumology, Feodor-LynenStraße 21; building M05, level 2, room 213) 25.04.16 3 – 5 p.m. 2 hrs Siegfried Weiss (HZI) Thomas Pietschmann Christine Goffinet Tutorial Pietschmann/ Gerold Ulrich Maus Tutorial Goffinet Monday 25.04.16 5 – 6 p.m. 1 hr Immune response in HIV Monday, 02.05.16 3 – 5 p.m. 2 hrs Tutorial Maus ditto location Monday, 02.05.16 5 – 6 p.m. 1 hr Inflammasomes and Autoinflammation Monday, 09.05.16 3 – 5 p.m. 2 hrs Tutorial Schmidt Monday, 09.05.16 5 – 6 p.m. 2 hrs No seminars, public holiday Monday 16.05.16 Reinhold E. Schmidt Lukas Bossaller 29 2. Genetics and disease Genetic susceptibility of infectious disease Monday 23.05.16 3 – 5 p.m. 2 hrs Tutorial Bossaller Monday 23.05.16 5 – 6 p.m. 1 hr Genetic engineering of cells and mice for development of disease models Monday, 30.05.16 3 – 5 p.m. 2 hrs Monday, 30.05.16 5 – 6 p.m. 1 hr Monday, 06.06.16 3 – 5 p.m. 2 hrs Tutorial Wirth Monday, 06.06.16 5 – 6 p.m. 1 hr Basic concepts in vaccinology Monday 13.06.16 3 – 5 p.m. 2 hrs Tutorial Stripecke Monday 13.06.16 5 – 6 p.m. 1 hr Innate lymphoid cells and their role in viral infection and vaccine design Monday, 20.06.16 3 – 5 p.m. 2 hrs Tutorial Guzman (HZI) Monday, 20.06.16 5 – 6 p.m. 1 hr Host-pathogen interactions Monday, 27.06.16 3 – 5 p.m. 2 hrs Tutorial Riese (HZI) Monday, 27.06.16 5 – 6 p.m. 1 hr Tutorial Medina Monday, 04.07.16 5 – 6 p.m. 1 hr Burkhard Tuemmler Dagmar Wirth (HZI) Tutorial Tuemmler 3. Infection and immune system Viral vectors for gene transfer in vitro and vivo Renata Stripecke Carlos Guzman (HZI) Peggy Riese (HZI) Eva Medina (HZI) Location entrance) Building I4, level SO (ground floor), seminar room S1400 (right to the main 30 4. Focus: Differentiation and Oncology 1. Development and cancer Cellular senescence as a barrier for cancer development Monday 04.04.16 3 – 5 p.m. 2 hrs No tutorial Monday 04.04.16 Liver organogenesis and hepatic stem cell differentiation Monday, 11.04.16 3 – 5 p.m. 2 hrs Tutorial Yevsa Monday, 11.04.16 5 – 6 p.m. 1 hr Epigenetics in cancer Monday, 18.04.16 3 – 5 p.m. 2 hrs Monday, 18.04.16 5 – 6 p.m. 1 hr Monday 25.04.16 3 – 5 p.m. 2 hrs Tutorial Lehmann Monday 25.04.16 5 – 6 p.m. 1 hr Metabolism and Cancer: Concept, Players,Therapy Monday, 02.05.16 3 – 5 p.m. 2 hrs Monday, 02.05.16 5 – 6 p.m. 1 hr Adoptive T cell therapies in hematopoietic stem cell Monday, transplantation 09.05.16 3 – 5 p.m. 2 hrs 09.05.16 5 – 6 p.m. 1 hr Tetyana Yevsa Michael Ott Ulrich Lehmann Tutorial Ott 2. Stem cells and cancer Tumor stem cells Matthias Christgen Anuhar Chaturvedi Tutorial Christgen Martin Sauer Tutorial Chaturvedi Monday, No seminars, public holiday Monday 16.05.16 T-box genes in development and disease Monday 23.05.16 3 – 5 p.m. 2 hrs Monday 23.05.16 5 – 6 p.m. 1 hr A. Kispert Tutorial Sauer 31 3. Signaling (and cancer) Oncogenes and myeloproliferation Monday, 30.05.16 3 – 5 p.m. 2 hrs Monday, 30.05.16 5 – 6 p.m. 1 hr Fibulin-G affects TGF signalling in context of cardiac Monday, remodelling 06.06.16 3 – 5 p.m. 2 hrs Matthias Eder Tutorial Kispert Christine Herzog Tutorial Eder Monday, 06.06.16 5 – 6 p.m. 1 hr Molecular mechanisms of senescence and their importance for aging in vivo Monday 13.06.16 3 – 5 p.m. 2 hrs Tutorial Herzog Monday 13.06.16 5 – 6 p.m. 1 hr Physiological functions of the septin cytoskeleton Monday, 20.06.16 3 – 5 p.m. 2 hrs Tutorial Hömme Monday, 20.06.16 5 – 6 p.m. 1 hr Molecular basis of leukemogenesis Monday, 27.06.16 3 – 5 p.m. 2 hrs Tutorial Menon Monday, 27.06.16 5 – 6 p.m. 1 hr Tutorial Schwarzer Monday, 04.07.16 5 – 6 p.m. 1 hr Meike Hömme Manoj Menon Adrian Schwarzer Location building I4, 2nd floor (Ebene 1), seminar room 1031 (Master program) 32 PhD programs “Infection Biology / DEWIN” 1st Semester Tutorials: Mondays, 15:15-16:15 hrs Location: Room 1140, Building J4, level1 Seminars: Mondays, 16:30-18:00 hrs Location: Lecture Hall B, Building J2 DATE TYPE FOCUS LECTURER SUBJECT 12.10.2015 Seminar Immunology I Krueger Episode I - The hematopoetic wonderland 19.10.2015 HBRS Opening: 17:00 - 19:00 hrs (Building J6, Level S0, Lecture Hall R) 26.10.2015 Seminar Immunology II Prinz What innate immune cells can do for you 02.11.2015 Seminar Immunology III Moschovakis B cells and antibody responses 09.11.2015 Seminar Immunology IV Lochner Multiple Choices - Induction and function of T helper cells 16.11.2015 Seminar Immunology V Behrens Divide and Conquer - Antigen presentation and cytotoxic T cells 23.11.2015 Seminar Microbiology I Suerbaum Introduction to Medical Microbiology Common themes in bacterial pathogenesis 30.11.2015 Seminar Microbiology II Bange Paradigms of Infection Biology: Mycobacteria 07.12.2015 Seminar Microbiology III Klos Paradigms of Infection Biology 33 DATE TYPE FOCUS LECTURER SUBJECT Paradigms of Infection Biology: The gastrointestinal habitat and its microbiota; Helicobacter and Campylobacter as specific pathogens of the niche 14.12.2015 Seminar Microbiology IV Josenhans 04.01.2016 Seminar Microbiology V Graßl Paradigms of Infection Biology Salmonella 11.01.2016 Seminar Microbiology VI Hofreuter Metabolism and Virulence 18.01.2016 Seminar Virology I Kraft 25.01.2016 Seminar Virology II Krey Virus Entry and Structural Virology 01.02.2016 Seminar Virology III Steinmann Virus Assembly, Maturation and Egress 08.02.2016 Seminar Virology IV Bohne Transcription and Replication of DNA Viruses 15.02.2016 Seminar Virology V Pietschmann Transcription and Replication of RNA Viruses 22.02.2016 Seminar Virology VI Viejo-Borbolla Pathogenesis, Host defense and viral interference Different Viruses and Viral Diseases 34 PhD Programs “Infection Biology / DEWIN” 2nd Semester Tutorials: Mondays, 15:15-16:15 hrs Location: Room 1140, Building J4, level1 Seminars: Mondays, 16:30-18:00 hrs Location: Lecture Hall B, Building J2 DATE TYPE FOCUS LECTURER SUBJECT 04.04.2016 Seminar Cell Biology I Hauser The cell cycle and its implications in disease 11.04.2016 Seminar Cell Biology II Brinkmann Intracellular trafficking 18.04.2016 Seminar Cell Biology III Stradal The structure of the cell's interior Times & Location: Mondays, 16:30-18:00 hrs, MHH, TPFZ/I-11, Seminar Room S0-1420 DATE FOCUS Project Presentation 25.04.2016 Project Presentation Project Presentation 02.05.2016 Project Presentation Project Presentation 09.05.2016 17.05.2016 Tuesday!! Topic Focus Project Presentation Project Presentation Project Presentation 23.05.2016 Project Presentation SUPERVISOR STUDENT Sodeik Otoo Schulz Nivia Wedemeyer Aregay Wedemeyer Soon Prinz Wilharm Prinz Martins Tümmler Pienkowska Goffinet Franz von Hahn Zapatero SUBJECT Characterization of functional domains in the large tegument protein pUL36 of Herpes-Simplex Virus Type 1 Developing Inhibitors of the Kaposi Sarcoma-associated Herpesvirus LANA protein Effect of anti-viral therapy and liver transplantation on T and NK cells during chronic hepatitis C Role of hepatitis E virus (HEV) infection in the induction of autoimmune hepatitis (AIH) Sentinels of the Oral Epithelium - Elucidating the Development and Function of Oral γδ T Cells and their Interplay with Langerhans Cells How γδ T cells regulate immune responses and immune tolerance Co-evolution of the intestinal and airways microbial metagenomes in people with cystic fibrosis Impact of Type I Interferons on Maintaining HIV-1 Latency Definition of a minimal set of cell surface molecules required for filovirus cell entry 35 DATE FOCUS Project Presentation 30.05.2016 Project Presentation Project Presentation 06.06.2016 Project Presentation Project Presentation 13.06.2016 Project Presentation Project Presentation 20.06.2016 Topic Focus Project Presentation 27.06.2016 Topic Focus SUPERVISOR STUDENT SUBJECT Graßl Sharma Bleich Meier Josenhans Ludwig Environmental dynamics of Helicobacter pylori in novel rodent models Förster Eckert Role of CCRL1 in controlling intestinal immunity Krey Naniima Molecular characterization of the capsid vertex specific component of herpesviruses Kalinke Ghita Virus control and pathology in herpes simplex encephalitis N.N. Identification of novel natural compounds as modulators of Dendritic cell activation Susceptibility of toll like receptor-11 deficient mice to Salmonella infections Cdcs1-determined colitis susceptibility: microbial factors Josenhans Kalinke Sparwasser 36 PhD Programs “Infection Biology / DEWIN” 3rd Semester Times & Location: Mondays, 16:30-18:00 hrs, MHH, TPFZ/I-11, Seminar Room S0-1420 DATE FOCUS SUPERVISOR STUDENT Topic Förster Raud 12.10.2015 Schirdewahn Original Paper 19.10.2015 26.10.2015 Costa Steinmann Original Paper 09.11.2015 16.11.2015 Topic focus Topic Focus Topic Original Paper Topic Topic focus Hickford 23.11.2015 Weiß Goffinet Nikolova B cell responses during infection Venugopalan Dejnirattisai et al., Nature Immunology Bhushal Functions of IFN-Lambda Nahrevanian Sodeik Original Paper Zhu Joecks Topic 30.11.2015 Ciesek Original Paper Topic Topic Focus Novel HCV inhibitors: from basic mechanisms to clinical use Gerold et al., Cell Reports, Quantitative proteomics identifies Krey Graßl Topic 07.12.2015 Differentiation and function of T-helper cells during infection Kashem et al., Immunity, Candida albicans Morphology HBRS Opening: 17:00 - 19:00 hrs (Building J6, Level S0, Lecture Hall R) Topic 02.11.2015 SUBJECT Villalvazo Bange Estibariz Assembly and maturation of herpesvirus capsids Rosato et al., PLOS Pathogens, Neuronal Interferon Signaling Epidemiology of HCV and its transmission Jurgeit et al., PLOS Pathogens, Niclosamide is a proton carrier Horizontal gene transfer in pathogenic bacteria and within the gastrotintestinal microbiota – mechanisms and biological relevance 37 DATE 14.12.2015 STUDENT SUBJECT Schirdewahn Activation and modulation of PAMPs + inflammasome during infection Original Paper Nikolova Härtlova et al., Immunity, DNA damage Topic Hickford FOCUS Topic 04.01.2016 SUPERVISOR Sparwasser Schulz Original Paper Costa Topic Samarina 11.01.2016 Cicin-Sain Kutle Original Paper Topic 18.01.2016 Original Paper Kalinke Topic 25.01.2016 Original Paper Hühn Topic 01.02.2016 08.02.2016 Restriction factors interfering with HSV infection Sheahan et al., Cell Host & Microbe, Interferon Lambda Alleles Molecular mechanisms of herpesvirus reactivation Stanton et al., Cell Host & Microbe, HCMV pUL135 Remodels Zhu Joecks Postherpetic neuralgia – underlying patho-mechanisms Ren et al., Scientific Reports, A DualReporter system Venugopalan Limiting the immune response Raud Kalia et al., Immunity, Quiescence of Memory CD8+ T Cells Villalvazo Viejo-Borbolla Cellular Entry Pathways used by different virus families van der Linden et al., PLOS Pathogens, The RNA Template Original Paper Nahrevanian Original Paper Bhushal Yang et al., Nature, Mesenchymal stem cells Estibariz LeRoux et al., eLife, Kin cell lysis is a danger signal Kutle Viral interference with the cellular ubiquitination system Hauser Topic focus 15.02.2016 22.02.2016 Original Paper Topic focus Topic Original Paper Suerbaum Brinkmann 38 PhD Programs “Infection Biology / DEWIN” 4th Semester Times & Location: Mondays, 16:30-18:00 hrs, MHH, TPFZ/I-11, Seminar Room S0-1420 DATE 04.04.2016 11.04.2016 18.04.2016 FOCUS SUPERVISOR STUDENT SUBJECT Project Presentation Pietschmann Joecks Pathways of Intracellular Lipoprotein Recruitment During Hepatitis C Virus Assembly and Maturation Topic Focus Pietschmann Project Presentation Sparwasser Raud Metabolic influences that regulate CD4 T cell function Topic Focus Sparwasser Project Presentation Ciesek Costa Impact of host variation in the SCARB1 gene on the development and maintenance of chronic hepatitis C Topic Focus Ciesek Project Presentation Förster Nikolova Project Presentation Förster Venugopalan Project Presentation Schulz Samarina A genetic approach to identifying host factors involved in herpesviral reactivation in humans Topic Focus Schulz Project Presentation Suerbaum Estibariz The dynamics of the methylome of Helicobacter pylori during human infection Topic Focus Suerbaum Project Presentation Wedemeyer Schirdewahn The role of NK cells and T cells in the pathogenesis of hepatitis delta Topic Focus Wedemeyer Project Presentation Messerle Kutle Project Presentation Messerle Nahrevanian 25.04.2016 02.05.2016 09.05.2016 17.05.2016 Tuesday!!! 23.05.2016 Role of memory T cells in adaptive immune responses Immune mechanisms controlling latent MCMV infections in mice Role of tegument proteins on acute and chronic mouse cytomegalovirus infection Strategies for identification and characterization of antivirals against cytomegalovirus 39 DATE 30.05.2016 06.06.2016 FOCUS SUPERVISOR STUDENT SUBJECT Project Presentation Hauser Bhushal Dynamics of IFN-virus interplay Topic Focus Hauser Project Presentation Viejo-Borbolla Zhu Modulation of the immune and nervous system mediated by human alphaherpesviruses Topic Focus Viejo-Borbolla Topic Focus Sodeik HickfordMartinez Topic Focus Sodeik VillalvazoGuerrero Topic Focus N.N. N.N. Topic Focus N.N. N.N. Topic Focus N.N. N.N. 13.06.2016 20.06.2016 27.06.2016 Retreats: November 11th, 2015 for the Class of 2014 February 3rd, 2016 for the Class of 2013 Intermediate Exam for the Class of 2014: March 16th, 2016 PhD Final Exams: January 22nd, 2016 June 17th, 2016 Cell-type specific cytosolic host factors interacting with HSV1 capsids Molecular characterization of small chemical compounds blocking HSV1 replication 40 PhD Program “Regenerative Sciences” Chairman of program committee: Vice-chairwoman: Professor Ulrich Martin Professor Renata Stripecke Times (in general): Tutorials Thursday, 3.00 – 4.00 pm Seminars Thursday, 4.15 – 5.45 pm 5th May 2016 is Ascension Day (‘Christi Himmelfahrt’) which is a public holiday. Therefore, this week’s teaching is changed to 3rd May 2016 (4th semester) or cancelled (2nd semester). Exceptions in day and time are printed in bold. Locations (in general) Semester 1 & 2 MHH, building I/J 04, level 01, HBRS seminar room 1140 Semester 3 & 4 MHH, building I/J 11, Hans-Borst-Zentrum (HBZ), level S0, seminar room 6040 Exceptions in location are marked * and **. 1st semester Introductory lecture 1 Welcome address, the curriculum of REBIRTH & HBRS, Q & A seminar * Thursday, 15.10.2015 4.15 – 5.45 pm Ulrich Martin Introductory lecture 2 Principles of regenerative sciences and the REBIRTH approach Seminar Thursday, 22.10.2015 2.30– 4.00 pm Ulrich Martin Seminar Thursday, 22.10.2015 4.15 – 5.45 pm Andreas Kispert Tutorial Thursday, 29.10.2015 3.00 – 4.00 pm Andreas Kispert Seminar Thursday, 29.10.2015 4.15 – 5.45 pm Thomas Thum Tutorial Thursday, 05.11.2015 3.00 – 4.00 pm Jan Fiedler Seminar Thursday, 05.11.2015 4.15 – 5.45 pm Amar Deep Sharma Tutorial Thursday, 12.11.2015 3.00 – 4.00 pm Amar Deep Sharma Principles of developmental biology and organogenesis 1 - Commitment, differentiation, apoptosis, patterning - Morphogenetic gradients and cell-cell communication - Genetic and epigenetic mechanisms Principles of cell engineering 1 - MicroRNAs (miRNA) and downstream targets - technical approaches - Use of miRNA target identification software - Design of miRNA - Luciferase-gene reporter assays (tutorial) Principles of stem cell biology 1 - Tumor stem cells and mechanisms of transformation - Principles of cell cycle regulation 41 Principles of stem cell biology 2 - Embryonic derivation of stem cells - Culture methods Principles of developmental biology and organogenesis 2 - Model systems in developmental biology - Embryogenesis and fetal development Seminar Thursday, 12.11.2015 4.15 – 5.45 pm Thomas Müller Tutorial Thursday, 19.11.2015 3.00 – 4.00 pm Thomas Müller Seminar Thursday, 19.11.2015 4.15 – 5.45 pm Achim Gossler Tutorial Thursday, 26.11.2015 3.00 – 4.00 pm Achim Gossler Seminar Thursday, 26.11.2015 4.15 – 5.45 pm Axel Schambach Tutorial Thursday, 03.12.2015 3.00 – 4.00 pm Axel Schambach Seminar Thursday, 03.12.2015 4.15 – 5.45 pm Siegfried Weiß Tutorial Thursday, 10.12.2015 3.00 – 4.00 pm Siegfried Weiß Seminar Thursday, 10.12.2015 4.15 – 5.45 pm Rainer Niedenthal Tutorial Thursday, 17.12.2015 3.00 – 4.00 pm Rainer Niedenthal Seminar Thursday, 17.12.2015 4.15 – 5.45 pm Michael Morgan Tutorial Thursday, 07.01.2016 3.00 – 4.00 pm Michael Morgan Seminar Thursday, 07.01.2016 4.15 – 5.45 pm Dagmar Wirth Tutorial Thursday, 14.01.2016 3.00 – 4.00 pm Dagmar Wirth Seminar Thursday, 14.01.2016 4.15 – 5.45 pm Wolfgang Ziegler Tutorial Thursday, 21.01.2016 3.00 – 4.00 pm Wolfgang Ziegler Seminar Thursday, 21.01.2016 4.15 – 5.45 pm Gudrun Göhring Tutorial Thursday, 28.01.2016 3.00 – 4.00 pm Gudrun Göhring Principles of cell engineering 2 - Transient DNA delivery - Episomal maintenance - Stable DNA delivery - Homologous recombination - Site-specific DNA modification Basic mechanisms of inflammation 1 - Innate and adaptive immunity Principles of growth factor signalling 1 - Paracrine and juxtacrine signalling - Signalling pathways involved in the regulation of growth and differentiation Principles of growth factor signalling 2 - Cytokines, hormones, and their receptors Synthetic biology and options for regeneration Cell polarity & cytoskeleton Principles of chromosomal instability 42 Basic mechanisms of inflammation 2 Infection & cancer Seminar Thursday, 28.01.2016 4.15 – 5.45 pm Ulrich LehmannMühlenhoff Tutorial Thursday, 04.02.2016 3.00 – 4.00 pm Ulrich LehmannMühlenhoff Principles of cell engineering 3 - Cell expansion - Bioreactors Seminar Thursday, 04.02.2016 4.15 – 5.45 pm Thomas Scheper tutorial** Thursday, 11.02.2016 3.00 – 4.00 pm Thomas Scheper Seminar Thursday, 11.02.2016 4.30 – 6.00 pm Anette Melk / Meike Hömme Tutorial Thursday, 18.02.2016 3.00 – 4.00 pm Anette Melk / Meike Hömme Cellular senescence, tumor suppression and organismal aging Please note the following changes: * The seminar (Ulrich Martin) on Thursday, 15th October 2015 will take place at MHH building I/J 11 (TPFZ), level S0, seminar room 1420. ** The tutorial (Thomas Scheper) on Thursday, 11th February 2016 will NOT take place at MHH but at the Institute of Technical Chemistry Leibniz Universität Hannover (LUH) Callinstr. 3 30167 Hannover Callinstr. 3 (LUH) can easily be reached by tram no. 4 directly from MHH to stop Schneiderberg/Wilhelm-BuschMuseum (20 minutes tram) 43 PhD Program “Regenerative Sciences” 2nd semester Principles of growth factor engineering - Engineering growth factors and their receptors for regenerative medicine - Molecular and structural approaches (tutorial) Principles of materials sciences for regenerative medicine 1 Introduction to biomaterials - Ceramic materials (seminar) - Chemistry (tutorial) Principles of materials sciences for regenerative medicine 2 - Nanoparticles (NPs) in medicine (seminar) - Nano-manufacturing & nanoanalytics using lasers (tutorial) Laser technology in medicine 1 Imaging - Basics of microscopy - Contrast mechanisms - Modern approaches in imaging - Superresolution microscopy Laser technology in medicine 2 Laser manipulation/machining - Surface treatment, structuring, polymerization - Laser-tissue interaction - Laser manipulation of cells Cardiovascular tissue engineering: Principles Principles of materials sciences for regenerative medicine 3 - Polymeric and metallic materials (seminar) - Cell-biomaterial interactions (seminar) - Cell technologies (tutorial) seminar* Thursday, 07.04.2016 3.00 – 4.30 pm Michael Morgan tutorial* Thursday, 07.04.2016 4.45 – 5.45 pm Michael Morgan / Trevor Huyton seminar* Thursday, 14.04.2016 3.00 – 4.30 pm Peter Behrens tutorial* Thursday, 14.04.2016 4.45 – 5.45 pm Peter Behrens seminar* Thursday, 21.04.2016 3.00 – 4.30 pm Laszlo Sajti tutorial** Thursday, 21.04.2016 4.45 – 5.45 pm Laszlo Sajti seminar* Thursday, 28.04.2016 3.00 – 4.30 pm Alexander Heisterkamp tutorial** Thursday, 28.04.2016 4.45 – 5.45 pm Alexander Heisterkamp seminar* Thursday, 12.05.2016 3.00 – 4.30 pm Boris Chichkov tutorial** Thursday, 12.05.2016 4.45 – 5.45 pm Boris Chichkov seminar Thursday, 19.05.2016 4.15 – 5.45 pm Andres Hilfiker tutorial Thursday, 26.05.2016 3.00 – 4.00 pm Andres Hilfiker seminar* Monday, 23.05.2016 3.00 – 4.30 pm Birgit Glasmacher tutorial* Monday, 23.05.2016 4.45 – 5.45 pm Birgit Glasmacher seminar Thursday, 26.05.2016 4.15 – 5.45 pm Willem Wolkers tutorial Thursday, 02.06.2016 3.00 – 4.00 pm Willem Wolkers Tissue processing and preservation 44 Animal models of human disease 1 - Murine models of human disease Animal models of human disease 2 - Primate models - Humanized mouse models Principles of organ transplantation 1 - Heart, lung, and vessels Animal models of human disease 3 - Transgenic pigs - Xenotransplantation - Donor animal engineering seminar Thursday, 02.06.2016 4.15 – 5.45 pm Achim Gossler tutorial Thursday, 09.06.2016 3.00 – 4.00 pm Achim Gossler seminar Thursday, 09.06.2016 4.15 – 5.45 pm Thomas Moritz / Nico Lachmann tutorial*** Tuesday, 14.06.2016 4.45 – 5.45 pm Thomas Moritz / Nico Lachmann seminar*** Tuesday, 14.06.2016 3.00 – 4.30 pm Axel Haverich et al. tutorial Thursday, 23.06.2016 3.00 – 4.00 pm Axel Haverich et al. seminar* Thursday, 16.06.2016 3.00 – 4.30 pm Heiner Niemann tutorial* Thursday, 16.06.2016 4.45 – 5.45pm Heiner Niemann seminar Thursday, 30.06.2016 4.15 – 5.45 pm Michael Ott tutorial Thursday, 07.07.2016 3.00 – 4.00 pm Michael Ott seminar Thursday, 07.07.2016 4.15 – 5.45 pm Robert Zweigerdt tutorial Thursday, 14.07.2016 3.00 – 4.00 pm Robert Zweigerdt Principles of organ transplantation 2 - Liver, pancreas, and ß-cells Stem cell based organ regeneration - Heart and ß-cells, and clinical translation Please note the following changes * The seminars on 7th, 14th, 21st, 28th April 2016 and 12th, 23rd May 2016 and 16th June 2016 will be immediately followed by the associated tutorial. The seminars and tutorials on 14th, 21st , 28th April and 12th and 23rd May 2016 will NOT take place at MHH, please find the respective addresses below. ** Teaching taking place at the Laser Centre requires registration one week in advance, i.e. Register until April 14th for the seminar on April 21st (Laszlo Sajti) Register until April 21st for the seminar on April 28th (Alexander Heisterkamp) Register until April 26th for the seminar on May 12th (Boris Chichkov) Please register with [email protected]; you may of course register for all 3 seminars at the same time. *** The seminar and tutorial will take place at building I/J 11 (HBZ) level S0, seminar room 6040. 45 Additional information on ‘Principles of materials sciences for regenerative medicine’, part 1, 2 and 3 General topics: - materials engineering, biomaterials in medicine - ex vivo and in vivo application - degradable materials - cell-biomaterial interactions Literature: Biomaterials Science (Third Edition), BD Ratner, AS Hoffman, FJ Schoen, JE Lemons (eds.) Elsevier Amsterdam 2013; available online, MHH library Lecturers and locations of lectures and tutorials: 14.04.2016 Prof. Dr. Peter Behrens Leibniz Universität Hannover (LUH) Institute for Inorganic Chemistry Callinstrasse 9, 30167 Hannover Tel.: +49 (0) 511 762 3660 Secr.: +49 (0) 511 762 3697; Fax: +49 (0) 511 762 3006 Email: [email protected] Callinstrasse 9 (LUH) can easily be reached by tram no. 4 directly from MHH to stop Schneiderberg/WilhelmBusch-Museum (20 minutes tram) 21.04.2016 PD Dr. Laszlo Sajti Laser Zentrum Hannover e.V. (LZH) Department: Nanotechnology Hollerithallee 8, 30419 Hannover Tel. +49 (0) 511 2788 149; Fax: +49 (0) 511 2788 100 Email: [email protected] LZH can easily be reached by tram no. 4 directly from MHH to stop Marienwerder/Wissenschaftspark (35 minutes tram) 28.04.2016 Prof. Dr. Alexander Heisterkamp Leibniz Universität Hannover (LUH) Institut für Quantenoptik Welfengarten 1, 30167 Hannover Tel. +49 (0) 0511 762 2231; Fax: +49 (0) 0511 762 2211 Email: [email protected] LUH can easily be reached by tram no. 4 directly from MHH to stop Leibniz Universität (20 minutes tram), Main Building, Building 1101, Room F 442 12.05.2016 Prof. Dr. Boris Chichkov Laser Zentrum Hannover e.V. (LZH) Department: Nanotechnology Hollerithallee 8, 30419 Hannover Tel. +49 (0) 511 2788 316; Fax: +49 (0) 511 2788 100 Email: [email protected] LZH can easily be reached by tram no. 4 directly from MHH to stop Marienwerder/Wissenschaftspark (35 minutes tram) 23.05.2016 Prof. Dr. Birgit Glasmacher Leibniz Universität Hannover (LUH) Institute for Multiphase Processes & Centre for Biomedical Engineering (zbm) Callinstraße 36, 30167 Hannover Secr.: Tel. +49 (0) 511 762 3828 ; Fax: +49 (0) 511 762 3031 Email: [email protected] Callinstrasse 36 (LUH) can easily be reached by tram no. 4 directly from MHH to stop Schneiderberg/WilhelmBusch-Museum (20 minutes tram) 46 PhD Program “Regenerative Sciences” 3rd semester Regenerative approaches: Blood and immunity 1 - Embryonic stem cell derived hematopoiesis Regenerative approaches: Blood and immunity 2 - Thymus and T-cell development - B-cell development - Flow cytometry Regenerative approaches: Blood and immunity 3 - Principles of hematopoietic stem cell transplantation and lymphocyte infusions - HLA system and HLA compatibility (tutorial) Regenerative approaches: Blood and immunity 4 - Genetic disorders of hematopoiesis - Leukemia and leukemogenic stem cells Regenerative approaches: Liver 1 - Physiology and pathophysiological changes of the liver - Liver cell therapy, basics in translation seminar Thursday, 08.10.2015 4.15 – 5.45 pm Bernhard Schiedlmeier tutorial Thursday, 15.10.2015 3.00 – 4.00 pm Bernhard Schiedlmeier seminar Thursday, 15.10.2015 4.15 – 5.45 pm Siegfried Weiß tutorial Thursday, 22.10.2015 3.00 – 4.00 pm Siegfried Weiß seminar Thursday, 22.10.2015 4.15 – 5.45 pm Matthias Eder tutorial Thursday, 29.10.2015 3.00 – 4.00 pm Constanca Figueiredo seminar Thursday, 29.10.2015 4.15 – 5.45 pm Axel Schambach tutorial Thursday, 05.11.2015 3.00 – 4.00 pm Axel Schambach seminar Thursday, 05.11.2015 4.15 – 5.45 pm Michael Ott tutorial Thursday, 12.11.2015 3.00 – 4.00 pm Michael Ott seminar Thursday, 12.11.2015 4.15 – 5.45 pm Michael Rothe tutorial Thursday, 19.11.2015 3.00 – 4.00 pm Michael Rothe seminar Thursday, 19.11.2015 4.15 – 5.45 pm Christine Falk tutorial Thursday, 26.11.2015 3.00 – 4.00 pm Christine Falk seminar* Thursday, 03.12.2015 3.00 – 4.30 pm André Bleich tutorial* Thursday, 03.12.2015 4.45 – 5.45 pm André Bleich seminar Thursday, 26.11.2015 4.15 – 5.45 pm Clemens Dasenbrock tutorial** Thursday, 10.12.2015 2.45 – 3.45 pm Clemens Dasenbrock Genotoxicity and monitoring Immunotoxicity and immunomonitoring Animal experiments 1 - Introduction to animal experiments - Presentation of the animal house Animal experiments 2 - Toxicity testing (inhalation) of biopharmaceuticals (seminar) - Animal house and equipment for inhalation toxicity testing (tutorial) 47 Measuring through the microscope: Quantitative structural assessment of organs, tissues and cells - Basic principles of design-based stereology (seminar) - Applications of stereology to the lung (tutorial) seminar Thursday, 10.12.2015 4.15 – 5.45 pm Matthias Ochs tutorial Thursday, 17.12.2015 3.00 – 4.00 pm Matthias Ochs seminar Thursday, 17.12.2015 4.15 – 5.45 pm Matthias Ballmaier tutorial Thursday, 07.01.2016 3.00 – 4.00 pm Matthias Ballmaier seminar Thursday, 07.01.2016 4.15 – 5.45 pm Renata Stripecke tutorial Thursday, 14.01.2016 3.00 – 4.00 pm Renata Stripecke Regenerative approaches: Liver 2 - Liver regeneration and stem cells - Stem cell-derived hepatocytes seminar Thursday, 14.01.2016 4.15 – 5.45 pm Michael Ott tutorial Thursday, 21.01.2016 3.00 – 4.00 pm Tobias Cantz Regenerative approaches: Liver 3 - Liver tissue engineering - Artificial liver / extracorporal devices seminar Thursday, 21.01.2016 4.15 – 5.45 pm Tobias Cantz tutorial Thursday, 28.01.2016 3.00 – 4.00 pm Tobias Cantz Regenerative Approaches: Pancreas 1 - Biochemistry/pathobiochemistry of pancreatic ß-cells seminar Thursday, 28.01.2016 4.15 – 5.45 pm Ortwin Naujok tutorial Thursday, 04.02.2016 3.00 – 4.00 pm Ortwin Naujok Regenerative approaches: Pancreas 2 - Differentiation of ES cells into insulinproducing cells seminar Thursday, 04.02.2016 4.15 – 5.45 pm Ortwin Naujok tutorial Thursday, 11.02.2016 3.00 – 4.00 pm Ortwin Naujok MicroRNAs in cardiovascular diseases - Regeneration and therapeutic approaches seminar Thursday, 11.02.2016 4.15 – 5.45 pm Thomas Thum tutorial Thursday, 18.02.2016 3.00 – 4.00 pm Thomas Thum / Sandor Batkai Cell sorting - Method based seminar - Visit to MHH sorter lab – instrumentation (tutorial) Regenerative approaches: Blood and immunity 5 - Antigen presenting cells Please note the following change * The seminar on 3rd December 2015 will be immediately followed by the associated tutorial. ** Tutorial: ‘Animal house and equipment for inhalation toxicity testing’ on 10th December 2015, 2.45 - 3:45 pm, location: Fraunhofer ITEM, Nikolai-Fuchs-Str. 1, Main entrance: Stadtfelddamm, seminar room S 1a 48 PhD Program “Regenerative Sciences” 4th semester Molecular biology of heart failure (seminar) Physiological measurements at mouse heart (tutorial) seminar Thursday, 07.04.2016 4.15 – 5.45 pm Jörg Heineke tutorial Thursday, 14.04.2016 3.00 – 4.00 pm Jörg Heineke Regenerative approaches: Heart and vessels 1 Angiogenesis und arteriogenesis in development and disease seminar Thursday, 14.04.2016 4.15 – 5.45 pm Florian Limbourg tutorial Thursday, 21.04.2016 3.00 – 4.00 pm Florian Limbourg Regenerative approaches: Heart and vessels 2 Cardiac differentiation of pluripotent stem cells & myocardial TE seminar Thursday, 21.04.2016 4.15 – 5.45 pm Ina Gruh tutorial Thursday, 28.04.2016 3.00 – 4.00 pm Ina Gruh seminar Thursday, 28.04.2016 4.15 – 5.45 pm Kai Wollert tutorial Tuesday, 03.05.2016 3.00 – 4.00 pm Kai Wollert seminar Tuesday, 03.05.2016 4.15 – 5.45 pm Ruth Olmer tutorial Thursday, 12.05.2016 3.00 – 4.00 pm Ruth Olmer seminar Thursday, 12.05.2016 4.15 – 5.45 pm Ruth Olmer tutorial Thursday, 19.05.2016 3.00 – 4.00 pm Ruth Olmer seminar Thursday, 19.05.2016 4.15 – 5.45 pm Michael Jagodzinski tutorial Thursday, 26.05.2016 3.00 – 4.00 pm Michael Jagodzinski seminar Thursday, 26.05.2016 4.15 – 5.45 pm Susanne Petri tutorial Thursday, 02.06.2016 3.00 – 4.00 pm Susanne Petri Regenerative approaches: Heart and vessels 3 Cell therapy for myocardial infarction: basic concepts and clinical applications Regenerative approaches: Lung 1 Regenerative approaches: Lung 2 Regenerative approaches: Cartilage, bone and tendon - mesenchymal stem cells, mesenchymal tissues - signaling pathways - autologous/ allogenic/ xenogenic/ prosthesis/ tissue engineering - animal models - translation: from basic research to clinical therapies - treatment options for bone fractures, osteoarthritis (articular cartilage damage), tendon ruptures Regenerative approaches: Nerve - Degeneration and regeneration in the central and peripheral nervous system - Animal models of acute and chronic neurotoxicity - Cell therapy in the nervous system: neuronal and non-neuronal cells - Application modes - Clinical trials 49 seminar Thursday, 02.06.2016 4.15 – 5.45 pm Christine Radtke tutorial Thursday, 09.06.2016 3.00 – 4.00 pm Christine Radtke seminar Thursday, 09.06.2016 4.15 – 5.45 pm Heiko von der Leyen HCTC tutorial Thursday, 16.06.2016 3.00 – 4.00 pm Heiko von der Leyen HCTC seminar Thursday, 16.06.2016 4.15 – 5.45 pm Ralf Cordes / Torben Söker Ascenion GmbH tutorial Thursday, 23.06.2016 3.00 – 4.00 pm Ralf Cordes / Torben Söker Ascenion GmbH seminar Thursday, 23.06.2016 4.15 – 5.45 pm Marc Barthold / Christoph Priesner tutorial Thursday, 30.06.2016 3.00 – 4.00 pm Marc Barthold / Christoph Priesner seminar Thursday, 30.06.2016 4.15 – 5.45 pm Ulrike Köhl / Stephan Klöss tutorial Thursday, 07.07.2016 3.00 – 4.00 pm Ulrike Köhl / Stephan Klöss seminar Thursday, 07.07.2016 4.15 – 5.45 pm Felix Hermann apceth GmbH & Co. KG seminar* Thursday, 14.07.2016 3.00 – 4.30 pm Cornelia Blume tutorial* Thursday, 14.07.2016 4.45 – 5.45 pm Cornelia Blume / Antonia Lavrentieva Regenerative approaches: Skin Design of clinical trials & regulation Patent Protection of academic inventions Quality Management – QM Good Manufacturing Practice (GMP), Advanced Therapy Medicinal Products (ATMP) Marketing and industrial partnerships Cell culture for production, testing, and tissue engineering* * The seminar on 14th July will be immediately followed by the associated tutorial. 50 Additional offers: Meet The Investigator Name Department Location Jörg Heineke Experimental Cardiology I/J 11, level S0, room 2nd June 6080 2016 Date Ulrich Martin* LEBAO MHH Elena LopezRodriguez Institute of Functional and Applied Anatomy MHH Laszlo Sajti LZH, Nanotechnology LZH Jan Fiedler IMTTS, IFB-Tx I/J 03, level 03, room 2040 Lung surfactant biology and methods in lung surfactant research Elena LopezRodriguez Institute of Functional and Applied Anatomy MHH RNA and DNA-basic methods Jörg Heineke Experimental Cardiology I/J 11, level S0, room th 9 June 2016 6080 Scientific working with Endnote and Reference Manager Ortwin Naujok Institute of Clinical Biochemistry IFB-Tx, MHH Real-time PCR & Analysis* Ortwin Naujok miRNA in thrombocytes Seema Dangwal Time Method Based Seminar Institute of Clinical Biochemistry Institute of Molecular and Translational Therapeutic Strategies (IMTTS) Basics of pathology in laboratory Susanne Rittinghausen Fraunhofer ITEM rodents *max. 8 participants Date and time for all semesters on appointment (registration required). 14th January 2016 or 21st January 2016 MHH MHH 17th February 2.00 pm 2016 Microscopy Room (ITEM) 17th November 2015 10.1511.45 am and 1.152.45 pm 51 PhD Program ”Auditory Sciences: Physics and Engineering, Physiology and Therapy of Hearing” For further information and registration please contact (if not noted elsewhere): [email protected] / [email protected] / [email protected] Obligatory courses: red: obligatory courses for all students; black: electives for UOL and LUH, obligatory for MHH Title Course organiser Credit Time and place 1.1 Clinic, Diagnostic and Therapy of Peripheral and Central Hearing Disorders Prof. Thomas Lenarz 25 hours 3 CP MHH building K6, node B, 6th floor, seminar room S66 1.2 Audiology and Physics of Hearing Prof. Hannes Maier 10 hours 1 CP MHH 1.3 Sensory Neuroscience Prof. Andrej Kral 25 hours 3 CP MHH 1.4 Imaging Methods in Medicine Prof.’in Lilli Geworski 25 hours 3 CP MHH building K7, floor S0, seminar room 1321 Participants: 5-20 students 1.5 Psychophysical Methods in Hearing Research Prof. Andreas Büchner 10 hours 1 CP MHH Seminar room “DHZ”, Hannover 1.6 Introduction to Biomaterials, Laser Spectroscopy and Microelectronics 1.7 Fundamentals of Auditory Physiology Prof. Peter Behrens Prof. Andreas Heisterkamp Prof. Holger Blume Prof.’in Christine Köppl Prof. Georg Klump 25 hours 3 CP LUH 30 hours 3 CP UOL 1.8 Summer School and Internal Retreat N.N. 20 hours 2 CP 15.-19.08.2016 Location tba 52 Elective courses at MHH: 2.1 Nanotechnology in Medicine Prof. Theo Doll 2.4 Sound Coding Strategies Jun.-Prof. Waldo Nogueira and Signal Processing Methods for Cochlear Implants and Hearing Aids 2.5 Anatomy of the Auditory Jun.-Prof.’in Simone Kurt System 12 hours 1 CP 15 hours 1.5 CP 10 hours 1 CP 2.6 Biomedical Technology PD Dr. Omid Majdani 10 hours 1 CP 12 hours 1-1.5 CP 2.7 Medical Image Processing for Medical Applications PD Dr. Omid Majdani Thomas Rau Georg-Jakob Lexow 2.8.1 Modulation of Basal Ganglia Activity in Movement Disorders by Functional Neurosurgery Prof. Joachim Krauss 1.5 hours 2.8.2 Animal Models for Psychiatric Disorders Prof.’in Kerstin Schwabe 1.5 hours 2.9 Auditory Plasticity Prof. Andrej Kral 25 hours 3 CP 2.10 Audiological Practical Course (incl. Stem Cell- and Molecular Biology of Hearing) Prof. Günter Reuter Prof.’in Andrea Hoffmann 25 hours 3 CP 2.11 Scientific Writing Prof. Andrej Kral 30 hours 3 CP 2.12 Lab Meeting Otolaryngology N.N. 1 hour / meeting MHH Conference room, 2nd floor, “HZH GmbH” (VIANNAbuilding), tba MHH On request NogueiraVazquez.Waldo@mh -hannover.de MHH On request Min. 4 students MHH On request MHH On request [email protected] MHH building K6, node B, 05th floor, seminar room 65 18.11.2015, 4:30 – 6:00 pm; [email protected] deadline: 13.11.2015 MHH building K6, node B, 05th floor, seminar room 65 02.12.2015, 4:30 – 6:00 pm; [email protected] deadline: 30.11.2015 MHH Conference room, 2nd floor, “HZH GmbH” (VIANNAbuilding), On request MHH, building K5, node F, 3rd floor, seminar room and labs, WS 2015 MHH VIANNA Starting 18.12.13 15:00-16:30; on request MHH Conference room, 2nd floor, “HZH GmbH” (VIANNAbuilding) Wednesdays 5-6pm 53 2.13 Journal Club (Neuroscientific Studies on Humans) N.N. 2 hours / meeting 2.14 Hearing(4all) Research N.N. Seminar 1 hour / meeting 2.15 Colloquium Medical Physics Prof.’in Lilli Geworski 1 hour / meeting 2.16 Lunchseminar Radiology Prof.’in Lilli Geworski 1 hour / meeting 2.17 Colloquium Radiology Prof.’in Lilli Geworski 1 hour / meeting 2.18 HNO-Meeting Prof.’in Lilli Geworski 1 hour / meeting MHH, building K5, node B, 3rd floor, seminar room 63, last Wednesday of the month 11am-1pm MHH Wednesdays every second month; 5 - 6pm; Place: tba Contact: [email protected] MHH, building K7, floor S0, seminar room 1321 Every second Tuesday 3 - 4pm, Registration required MHH Radiology Wednesdays, 12am - 1pm Registration required MHH Radiology Tuesdays 08:15 - 09:00am Registration required MHH Neuroradiology Date per request Registration required Elective courses at the University of Veterinary Medicine Hannover, Foundation: 2.19 Neurobiology of Acoustic Communication and Orientation Prof.’in Elke Zimmermann PD Dr. Sabine Schmitt 25 hours 3 CP TiHo, Bünteweg 17, Summer 2016 [email protected] participants: 4-8 students Prof. Holger Blume 12 hours 1 CP LUH / IMS Seminar room 335 Appelstr. 4, 3rd floor Hannover Elective courses at LUH: 2.20 Basics of Digital Systems Two days in spring 2016 10am - 1pm, 2pm - 5pm (each day) 54 2.21 Application-Specific Instruction-Set Processors for Hearing Aid Systems 2.22 Principles of Signal Processing in MATLAB Jun.-Prof. Guillermo Payá Vayá Jun.-Prof. Guillermo Payá Vayá 12 hours 1 CP 12 hours 1 CP LUH / IMS Seminar room 335 Appelstr. 4, 3rd floor Hannover Two days in spring 2016 10am - 1pm, 2pm - 5pm (each day) LUH / IMS Seminar room 335 Appelstr. 4, 3rd floor Hannover Two days in spring 2016 10am - 1pm, 2pm - 5pm (each day) Elective courses at UOL: 2.23 Signal Processing and Prof. Simon Doclo Acoustics I 40 hours 4 CP UOL Tba (February/March 2016) 2.24 Signal Processing and Prof. Simon Doclo Acoustics II 25 hours 3 CP UOL Tba (February/March 2016) 2.25 Methods in Hearing Research - Introduction to Biomedical Physics and Acoustics 25 hours 3 CP UOL Thursday: 4 - 6 pm, weekly, beginning 16.04.2015 25 hours 3 CP UOL 30.09.-01.10.2015 Prof. Birger Kollmeier, Prof. Simon Doclo 2.26 Neurophysiological Prof.’in Christiane Thiel Imaging and Data Analysis Prof. Stefan Debener (in Hearing Research) EEG and fMRI Combined electives: 2.27 Combined Hot Topic Seminar (Web Conference) Odett Kaiser Jacqueline LeßigOwlanj 2 h/seminar Dates: tba 55 PhD Program “Epidemiology” Chairman of program committee: Prof. Dr. Gérard Krause Coordination: Dr. Jördis Ott & Dr. Stefanie Castell Location: Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany Study Centre of German National Cohort and of the Helmholtz Centre for Infection Research, Hannover, Germany Epidemiologic Fieldwork: Module* Type Outbreak investigation and surveillance Good Epidemiological Practice and its practical application Data Analysis I Lectures, exercises, practical application Lecture and exercise Data Analysis II Data Analysis III Epidemiologic field work Laboratory methods in infectious disease epidemiology (“Spring School”) Journal Club Dates Semester 2015/16 Spring/summer 2016 Duration Lecturer/organizer 30 hrs (one week module) Gérard Krause and team. July 2016 5 hrs Stefanie Castell Jördis Ott Lectures and exercises Lectures and exercises Lectures and exercises Practical work in the study center of the German National Cohort or at other field locations. Lectures and practical laboratory work including site visits. 15-16 Oct 2015 22-23 Oct 2015 Summer 2016 30 hrs 30 hrs Rafael Mikolajczyk and team Rafael Mikolajczyk Summer/Fall 2016 30 hrs Rafael Mikolajczyk Individual dates for each student. One week module. Yvonne Kemmling and team. May 2016 30 hrs (one week module) Claudia Sievers Presentations by students. Ongoing on a monthly basis. 1 hr (monthly) Jördis Ott Stefanie Castell * Teaching modules in the PhD Programme Epidemiology are organized as compact courses, taught on subsequent days. Students of the PhD Programme Epidemiology and located at the HZI can attend courses and symposia offered by the HZI Grad School. Students of the PhD Programme Epidemiology are encouraged to attend courses at institutes of the MHH and of the HBRS at the MHH. CPs/hours can be accredited after consulting with the coordinating team and in line with the requirements of the program. The annual PhD retreat of the Programme Epidemiology takes place on 18 September 2015 in Braunschweig. Attendance is mandatory for all PhD students in the programme. 56 TECAS European Doctoral Academy in Regenerative Engineering Marie Curie Initial Training Network “Tissue Engineering Solutions for Cardiovascular Surgery” Chairman of program committee: Vice-chairman: Dr. Sotiris Korossis Prof. Dr. Axel Haverich Modules/activities compulsory for Marie Curie Fellows are listed in the table below (see notes 1 and 2). Courses will be delivered on the condition that there are at least 5 registered participants. Location: Building M07, level 1, seminar room Title A rookie’s guide to the PhD Degree Type Lecture Lecture Statistical analysis Tutorial Principles of material mechanics - Loading and Lecture/Tutorial support - Free body diagrams - Stress/strain concept - Elastic properties Lecture/Tutorial - Viscoelastic properties Biomaterials for tissue engineering - Biological scaffolds - Polymeric scaffolds TE bioreactors - Bioreactor types - Bioreactor design - Case studies Lecture Tutorial Lecture Date Tuesday, 10.11.2015 AND Tuesday, 17.05.2016 Tuesday, 10.11.2015 AND Tuesday, 17.05.2016 Wednesday, 11.11.2015 AND Wednesday, 18.05.2016 Wednesday, 11.11.2015 AND Wednesday, 18.05.2016 Friday, 13.11.2015 AND Friday, 20.05.2016 Tuesday, 17.11.2015 AND Tuesday, 24.05.2016 Wednesday, 18.11.2015 AND Wednesday, 25.05.2016 Tuesday, 17.11.2015 AND Tuesday, 24.05.2016 Time/Duration Lecturer/Organiser 14.00 – 15.00 Sotiris Korossis 15.00 – 18.00 Sotiris Korossis Daniele Dipresa 10.00 – 13.00 Sotiris Korossis Daniele Dipresa 14.00 – 17.00 14.00 – 17.00 Sotiris Korossis Sotiris Korossis 10.00 – 13.00 Sotiris Korossis Lucrezia Morticelli 15.00 – 18.00 Sotiris Korossis Lucrezia Morticelli 14.00 – 17.00 Sotiris Korossis 57 Friday, 20.11.2015 AND Friday, 27.05.2015 Tutorial Title Type Exchange Secondment 1 3 Laboratory practical Exchange Secondment 2 3 Seminar Clinical Secondment 4 Laboratory practical External Secondment 5 Laboratory practical Industrial Secondment 6 Industrial placement Transferable Skills Workshop 7 Translation, Commercialisation and Standardisation Workshop 8 Semester(s) To be individually arranged for each Fellow To be individually arranged for each Fellow To be individually arranged for each Fellow To be individually arranged for each Fellow To be individually arranged for each Fellow Lecture Tutorial 04.12.2015 Lecture 03.12.2015 Tutorial 14.00 – 17.00 Sotiris Korossis Duration Organiser max 3 months Sotiris Korossis max 1 month Sotiris Korossis 1 month Sotiris Korossis max 2 weeks Sotiris Korossis 1 month Sotiris Korossis Sotiris Korossis 09.00 – 17.00 RWTH Aachen University, Aachen Sotiris Korossis, Michael Harder 09.00 – 17.00 RWTH Aachen University, Aachen 58 IMPORTANT NOTES 1. TECAS Marie Curie Fellows are required to attend 300 hours of lectures and seminars from the TECAS Curriculum offered by the TECAS Partners (HBRS; Eindhoven University of Technology; RWTH Aachen University; University of Padua; University of Patras). In addition, TECAS Marie Curie Fellows are required to attend the annual Women in Science & Engineering Days and the Annual Work-in-Progress Meetings organized by the TECAS-ITN. 2. TECAS modules are offered at both Winter and Summer Semester. 3. Exchange Secondments can be organised for a maximum of 4 non-TECAS students per year after consultation and agreement with their project supervisors, provided that their travel and living expenses are covered by them. TECAS Marie Curie Fellows are required to undertake 2 Exchange Secondments to other TECAS-ITN academic partners (University Hospital Aachen, Eindhoven University of Technology, University of Padua, University of Patras) to gain training in projectspecific techniques or equipment (Exchange Secondment #1) and transferable skills (Exchange Secondment #2) not available in Hannover Medical School. The secondments of the Fellows will not exceed the 30% of their total Fellowship period. 4. Clinical Secondments can be organised for a maximum of 2 non-TECAS students per year after consultation and agreement with their project supervisors provided that their travel and living expenses are covered by them. TECAS Marie Curie Fellows are required to undertake 1 Clinical Secondment with one of the affiliated hospitals (Hanover Medical School, Padua University Hospital, Aachen University Hospital). The Clinical Secondment will be undertaken in the transplant services of the affiliated hospitals and will familiarise the Fellows with standard practices and methodologies used for retrieval, storage, processing and issue of human tissues for transplantation purposes. The secondments of the Fellows will not exceed the 30% of their total Fellowship period. 5. This Secondment is only available to TECAS Marie Curie Fellows. Depending on the their research and training needs, TECAS Marie Curie Fellows are required to undertake 1 External Secondment to an academic or industrial institution outside the TECAS-ITN. This scheme will offer access to specialised equipment and techniques not available among the TECAS-ITN partners. The secondments of the Fellows will not exceed the 30% of their total Fellowship period. 6. This Secondment is only available to TECAS Marie Curie Fellows. TECAS Marie Curie Fellows are required to undertake 1 Industrial Secondment with one of the industrial TECAS-ITN partners (Corlife, ROWIAK, 3T). The Industrial Secondment will provide the Fellows with experience of working in the medical implant industry, and familiarise them with aspects and issues relevant to clinical translation, standardisation and/or commercialisation of their research. The secondments of the Fellows will not exceed the 30% of their total Fellowship period. 7. The Transferable Skills Workshop will be hosted at RWTH Aachen University, Aachen. The workshops will be delivered in the form of lectures, tutorial and interactive activities and will focus on research ethics, leadership and team work, entrepreneurship, time management, networking skills, media training, writing for non-scientific press, public awareness & engagement, presentation skills, and event organisation. Students that wish to participate in the Workshop are required to notify the organizer at least two months in advance. 8. The Translation, Commercialisation and Standardisation Workshop will be hosted in Eindhoven University of Technology, Netherlands and it is open to all HBRS students. The workshop will aim to deepen the understanding on the commercialisation and standardisation challenges facing regenerative medicine along the innovation pipeline from the bench to the bedside. The workshop will comprise lectures and Q&A sessions on preclinical testing, tissue sterilisation, preservation and banking, risk assessment and quality management, European regulation, and ISO standards. Students that wish to participate in the Translation, Commercialisation and Standardisation Workshop are required to notify the organizer at least two months in advance. 59 Specific seminars and practicals (see special announcements provided by the HBRS office, program offices and the respective departments) Organized by the HBRS Office: Presentation of projects/retreat (weekend, 2 days; for MD/PhD MM: March 3rd/4th, 2016) Gene Technology Security (September 2016, in English) Translation workshop (Drug development, Patenting, Clinical Studies etc.: May 2016) Career Day (March 18th, 2016) GMP/ GLP workshop (December 9th, 2016, Fleischauer & further representatives of ITEM) Scientific communication/writing, “tipps and tricks” (January 15th, 2016, Kruse) Scientific writing, advanced (February 2016 John Chandler) Animal Experiments (3 days, in the week November 16th-20th, 2016, Bleich/ Dorsch) Conflict Management (December 1st/2nd, 2016, G. Kümmele, Berlin) and Stress Management (January 12th/13th 2016, G. Kümmele) Time Management (April 6th, 2016 Golin) Team Work and Leadership (April 20th, 2016 Golin) Intercultural communication (weekend, June 10th-12th 2016; A. and S. Petersen, Aachen; together with MSc/PhD programs in Göttingen) Seminars on career perspectives (continuously) Further courses: Assessment Center, Job hunting, Project Management, Team Building, Weekend workshop German culture etc. will be announced in course of the year. Seminars offered by Helmholtz Centre for Infection Research Braunschweig, Twincore, Fraunhofer Institute or TiHo: see announcements Lectures (see special announcements and websites) Interdisciplinary Seminars of the IRTG Seminars of the SFBs Seminars of Clusters of Excellence” Immunological Colloquium Biochemical Colloquium Gastroenterology Colloqium Microbiological Colloquium, Virological Colloqium Biological and Biochemical Questions (BBQ) 60 In the departments (a must!!) - Lab-Seminars Journal-Clubs (these should be in English!) Internal practical courses The supervisors will provide you with special practical trainings if needed. You might also ask your cosupervisors or fellow PhD students for help. Program offices and HBRS will offer a number of short practical courses (see announcements). German Classes Tuesdays: 4.00 p.m. – 6.00 p.m. (beginners, Gudrun Dettmar), HBRS seminar room 1140 (building I 4, level 01); Tuesdays: 5.00 p.m. – 7.00 p.m. (advanced, Mrs Gesine Mann) Fridays Mrs Gudrun Dettmar (on demand) Scientific English Mondays: 6.15 p.m. – 7.30 p.m.; Mrs Lydia Lange; HBRS seminar room 1140 (I 4, level 01) Optional Note: You are welcome to visit most of the seminars/courses organized for the German Biology and Biochemistry students, as well as medical students. You are also welcome to visit seminars/courses offered by all programs of HBRS [including the Graduate School at the University of Veterinary Medicine Hannover (TiHo)]. http://www.mh-hannover.de/hbrs.html http://www.helmholtz-hzi.de 61 Rules and Requirements for Postgraduate (PhD) Studies and Examinations in structured doctoral programs of Hannover Biomedical Research School (HBRS), Hannover Medical School On December 15th, 2000 the Senate of the Hannover Medical School approved the following Rules and Requirements for Postgraduate (PhD) Studies and Examinations in structured doctoral programs of Hannover Biomedical Research School (HBRS) (alternatively Dr.rer.nat. for life scientists). (Modifications on June 4th 2002, February 11th 2004, April 21st 2005, March 14th 2007, April 15th 2009, November 9th 2011, November 14th 2012 and June 18th 2014) §1 Objective of PhD Studies Research studies at the Hannover Medical School (MHH) for the purpose of obtaining a PhD degree (hereinafter referred to as PhD studies) shall facilitate postgraduate training with a focus on specific research projects with a view to enabling the candidate to do in-depth scientific work on his or her own and to provide him or her with additional professional qualifications for future assignments in research or related areas of work. PhD studies shall foster the development of outstandingly gifted up-andcoming academics. The standard time allowed for completing PhD studies shall be three years. Once these PhD studies have been successfully completed, and the PhD examination has been passed, the MHH will award the degree of a Doctor of Philosophy (PhD) to medical students (including dentists), veterinarians, pharmacists, engineers, life scientists, and graduates with biomedical or health science related focus or Dr. rer. nat. to natural scientists and pharmacists (not to medical students). §2 Requirements for Access and Admission (1) Anybody having successfully completed university studies in medicine, veterinary medicine, engineering, pharmacy, natural sciences or biomedical/ health science focus (normally Master, Diploma or Staatsexamen) shall have access to PhD studies. (2) Applicants are required to render evidence of above-average results obtained at university. The applicant’s past career must reveal his or her particular qualification for and dedication to scientific work. Decision on whether or not a candidate qualifies for access to PhD studies is up to the PhD Program Committee (§ 4). §3 Admission to PhD Studies (1) The number of applicants that can be admitted to PhD studies is limited; the number depends on the respective program. The respective PhD Program Committee shall select the applicants to be admitted (§ 4). As a rule, the President of the MHH will give notice of the date of commencement of PhD studies once a year. (2) Details of the as a rule three-step selection process (written application, written test in home countries or selection by program committee, interview) are regulated in the respective program ‘rules of admission’. (3) Application papers shall be submitted to the chairperson of the PhD Program Committee. Details of current application procedures are described on the website of HBRS. (4) On the basis of this application the PhD Program Committee shall decide on admission to PhD studies. (5) At MHH, candidates are enrolled as PhD students for the whole duration of their PhD work. Matriculation is done at the beginning of studies (usually winter semester). 62 §4 PhD Program Committee (1) The respective PhD Program Committee shall be responsible for the conduct of PhD studies according to the Rules and Requirements for postgraduate studies and examinations to obtain a PhD (Dr.rer.nat.) degree. (2) As a rule, the PhD Program Committee shall be composed of four professors (or competent habilitated/senior scientists), a university scientist with a doctoral degree, and student representatives of every study year who have a joint vote. Members of the PhD Program Committee shall be appointed by the scientists of a respective program for a period of four years, or two years in case of student members. Re-election shall be possible. The PhD students shall suggest candidates from among their ranks. The respective PhD Program Committee shall be affirmed by the Research Committee of MHH. The PhD Program Committee is then constituted by the Dean of HBRS and shall elect a professor from among its ranks as chairman. (3) The PhD Program Committee will meet regularly. (4) The PhD Program Committee will evaluate proposed projects (open projects) according to quality (with external referees if necessary), financial support, guarantee of independence for PhD students. (5) The PhD Program Committee shall appoint a team of co-supervisors (thesis advisory board) for each PhD student. Team members shall be habilitated or equally qualified. The team of co-supervisors shall be composed of the student’s personal supervisor at the MHH or partner institutes, and two further scientists qualified as university teachers whose professional activity shall be closely related to the subject of the project. In case of several PhD students doing research in the same line, the respective cosupervisors’ teams can be composed of the same individuals. §5 Contents of Studies (1) The contents to be learned shall be conveyed to the students through their experimental or equivalent theoretical research work and through project-related as well as inter-disciplinary research-oriented courses and seminars. For that purpose, the PhD Program Committee shall prepare and submit, after consultation with the university institutions or partner institutes involved in these studies, a curriculum indicating compulsory and recommended courses or seminars for each discipline. The courses and seminars shall be held by the teachers and professors of the MHH as well as partner institutes, including visiting professors. Teaching shall be in English. Lectures and seminars of different programs are mutually acknowledged. PhD students may also register for suitable courses or seminars offered by other scientific schools (Leibniz University, University of Veterinary Medicine, etc.). Students are encouraged to do active teaching themselves, e.g. by giving lectures at seminars or postgraduate research training programs [Doktorandenkolleg]. Each student’s individual progress at PhD courses and seminars shall be monitored and consistently assessed by the respective teachers, with teachers preparing written reports on the results obtained by the student. (2) PhD students shall design, after consultation concert with their co-supervisors, their respective individual schedules pursuant to the curriculum established by the PhD Program Committee. Such individual schedule shall require approval by the respective co-supervisors’ team. The student must complete a minimum of 300 hours at courses and seminars during his or her PhD studies; as a rule, at least 80% thereof must be taken at project-related courses and seminars and up to 20% may be spent on interdisciplinary learning (e.g. experimental techniques and bio-informatics, molecular biology, biostatistics, scientific communication etc.). During the first year of PhD studies, courses for physicians, dentists and veterinarians are intended to provide participants with a chance to consolidate their knowledge of the fundamental principles of natural sciences and courses for natural scientists are intended to consolidate their knowledge in medical aspects. 63 (3) PhD students could apply for a leave if justified (e.g. in case of pregnancy), but for no more than 12 months. Short time stays abroad are very much appreciated and will be supported. If students take seminars and courses abroad, they could be acknowledged for the respective PhD program. §6 Supervision (1) PhD students shall supervised by the members of their respective thesis advisory board (§ 4) appointed by the PhD Program Committee. The responsibilities of the team shall be: a) To act as co-supervisors and to give individual expert advice to PhD students all through their PhD studies. b) To evaluate PhD students’ progress during their studies by receiving their reports (annually) and conducting exams; and to assess their written final examination papers. c) Within a time of probation of 6 months, PhD students are evaluated. Within this time peroid, student status can be changed easily on both sides in agreement with the team of co-supervisors and PhD Program Committee. The PhD Program Committee can upon request decide about the termination of collaboration with the student. d) Within the scope of their research project, students have to work with appropriate methods on a clearly defined subject so that, with some realistic prospect of success, scientific knowledge can be expected to be incremented and the results of such research should be published in international peer-review journals. The co-supervisors shall make sure, and satisfy the PhD Program Committee to that effect, that students are not entrusted with any tasks unrelated to their PhD studies. (2) The co-supervisors shall be responsible for the financing of the respective research project and shall make efforts, during the standard period of PhD studies (three years), to raise the money needed for the PhD students they are in charge of. Any scholarships available at the MHH shall be awarded by resolution of the HBRS Committee of MHH. (3) Co-supervisors should assist PhD students in planning their further professional career. (4) The responsibilities of co-supervisors for PhD students shall end upon the date when the latter pass their PhD examination (§ 10), which is normally three years but no later than five years after commencement of PhD studies. §7 Scientific Colloquia (retreats) PhD students shall be invited annually by the PhD Program Committee to attend a public colloquium (retreat), giving them an opportunity to give a presentation on the current status of their research (§5). The contents of such presentation, constituting an interim report, shall be submitted in writing by the PhD student to the PhD Program Committee. The PhD Program Committee shall decide whether or not this progress report constitutes a sufficient step towards the successful completion of the student’s research. If the Committee’s comment is negative, such result shall be communicated in writing to the student and his or her co-supervisors’ team, indicating the reasons. Pursuant to a period of one month, the student shall submit a modified work plan for the next year of his research, giving due consideration to the recommendations made. 64 §8 Intermediate Examination The oral intermediate examination shall be held no later than 18 months after commencement of PhD studies. By way of exception, which must be well-founded, the intermediate examination can be taken at a later date. If a student wishes such exception, he shall apply in writing to the PhD Program Committee adding a comment prepared by his co-supervisors’ team. The dates for intermediate examinations shall be determined by the PhD Program Committee. The intermediate examination shall be held by a member of the PhD Program Committee and an expert (chairman) in the special field and shall cover topics from the student’s research project and from the courses and seminars the student has registered for. The examination usually is held in English. If the student fails the intermediate examination he shall be allowed to retake it once, pursuant to a period of at least three and no more than six months as the examiners may decide. If the student fails again, he or she shall be deemed to have finally and absolutely failed. Following such final and absolute failure the student shall be taken off the register. The “chairman” shall report the result of the intermediate examination to the PhD Program Committee. The result of the exam will account for 20% of the final mark (PhD or Dr.rer.nat.). §9 Requirements for Signing up for PhD Examination After completion of PhD studies, which is normally at the end of the third year, the PhD examination shall be held. The PhD student shall submit the following documents when signing up for the PhD examination: 1. Certificate of regular attendance at and completion of courses and seminars according to the curriculum, i.e. a total of at least 300 hours, and of three colloquia pursuant to § 7; 2. Certificate of intermediate examination; 3. A scientific thesis (dissertation) prepared in English or German by the PhD student on the research project the student worked on during his or her PhD studies, with introduction, materials and methods, results, discussion and summary. The thesis shall constitute an essential original scientific contribution to the discipline the student’s research project pertains to; 4. Alternatively (instead of thesis), usually two first author publications in internationally peer review science journals. The PhD student’s personal contribution to such publications shall be clearly identified. In that context, “accepted” shall be deemed equivalent to “published”. As for this publication requirement, exceptions are possible with reasons to be given by the supervisor. The publications must be in one scientific context, and shall be supplemented by a detailed description under a joint title in English or German of the research subject, including an overall summary and a discussion of results. The final version of the dissertation should be submitted in six printed copies as well as a digital version. To assess the thesis or the publications, the PhD Program Committee shall procure at least one external expert’s opinion, as well as one internal expert’s opinion. To be on the save side, one expert shall be nominated as substitute in case of unforeseen drop outs. For the Dr. rer. nat., at least one of the experts has to have a natural scientist qualification. In addition, the co-supervisors’ team shall prepare an expert report on the dissertation or the publications, and such report together with the external and internal expert’s opinion shall serve to make the final assessment. If one of the expert reports detects any shortcomings in the dissertation, the PhD Program Committee can be requested to have such shortcomings eliminated or remedied as a precondition for acceptance of the thesis. The chairperson can allow a reasonable period for the PhD candidate to remedy the shortcomings and recommend that he or she submit the thesis anew. In that respect, the chairperson of the PhD Program Committee can extend this period once only. The experts shall assess the thesis again once the shortcomings have been remedied. 65 If, based on such second experts’ vote, the PhD Program Committee declines to accept the thesis, the candidate shall be deemed to have failed the PhD examination finally and absolutely. In that case, the PhD student shall be taken off the register. § 10 PhD Examination The PhD examination consists of a public presentation (usually 15-20 min, in English) held by the PhD student at the Hannover Medical School on the subject of his research, a subsequent public disputation of the project of at least 30 minutes of duration to assess the knowledge acquired by the student on the subject of his specific area of research as well as on interdisciplinary subjects. The interview also serves to assess whether the candidate has acquired, and is able to apply, any knowledge and skills relating to the scientific environment of the subject of his research. The examination is taken by the external and internal examiner. The final mark results from: the intermediate exam (20%), the written dissertation/ the two experts’ opinions (60%), the oral examination (20%). In justified exceptional cases, the examination committee may deviate from the latter rule. The oral examination shall be taken on record in abridged form and shall indicate: the grade earned for the oral examination, the grade earned for the thesis, the overall grade average earned for the PhD examination. It shall be signed by the chairman of the board of examiners. The following grades can be awarded: Excellent/ very good/ good / satisfactory (Failed) Equivalent to excellent / summa cum laude, very good / magna cum laude, good / cum laude, passed / rite. If the candidate fails the final examination, he or she shall be allowed to retake it once, pursuant to a period of at least three and no more than six months as the co-supervisors’ team may decide. Should the student then fail again, he or she shall be deemed to have finally and absolutely failed the PhD examination. Following such final and absolute failure the student shall be taken off the register. The result of the PhD examination shall be communicated to the PhD Program Committee and the President’s office (in case of failure with reasons and instructions about a person's available legal remedies). § 11 and § 12 Publication and Award of the Academic Degree of a Doctor of Philosophy (PhD) PhD students are obliged to publish their dissertation. Once the student has passed the PhD examination and has distributed six copies of the dissertation (plus one electronic version), he or she shall be awarded the academic degree of a Doctor of Philosophy (PhD) or a Dr. rer. nat. degree by the MHH (latest one year after the PhD exam). Formatting has to be done according to the rules of MHH library. The publication in form of a monograph is allowed if it is clearly indicated that the dissertation has been published by MHH. A document as shown in Appendix 1 shall be issued to him or her in evidence of such award. The award shall authorize the candidate to use the academic title of a PhD or Dr. rer. nat.. 66 § 13 Withdrawal of PhD exam registration The registration for the PhD exam (submission of PhD thesis) can be withdrawn by a written declaration to the program committee. § 14 Resumption of PhD exam (1) If a candidate ultimately fails a PhD exam all German universities have to be notified. (2) A new registration for PhD exam can only be done once, only after three and at the most eight months. This also applies when a failed PhD exam has been taken at another German university. § 15 Abrogation of PhD If by error requirements for PhD registration have been taken for granted or if the candidate has strongly violated the rules of “good scientific practise”, the president of MHH can abrogate the PhD title after having consulted the PhD committee. § 16 Revocation of PhD title The PhD title is revocated in cases of criminal conviction or strong violation against the rules of “good scientific practise” in the PhD thesis. The decision is to be delivered to the aggrieved party. § 17 Coming into Effect The Rules and Requirements for Postgraduate Studies and Examinations in structured doctoral programs of Hannover Biomedical Research School (HBRS) to obtain a PhD degree (or Dr. rer. nat.), as approved by me, are hereby published within the Hannover Medical School and are coming into effect. Hannover, The President Professor Dr. Christopher Baum Appendix 1 (MHH Logo) Hannover Medical School under the presidency of Professor Firstname Lastname awards to Firstname Lastname Born on DD Month YYYY in town, country the degree of Doctor rerum naturalium (Dr. rer. nat.) / Doctor of Philosophy (PhD) in recognition of his/her successful participation in the Hannover Biomedical Research School and the PhD Program XXX, the scientific standard of his/her research thesis TITEL, performed at the Institute at University and its public defense showing his/her ability for profound independent scientific work with the overall mark excellent (summa cum laude) / very good (magna cum laude) / good (cum laude) / sufficient (rite) Hannover, DD Month YYYY Signature Signature Chairman/woman PhD ProgramPresident 5 3J 2 1 4 6 Twincore ITEM 1: Building J4 (Forschungswerkstätten) MD/PhD/ HBRS Office; HBRS seminar room 1140; Seminar room 1031, level 1, Seminar room S1400 (ground), Seminar room Cell Biology (level H) 2: TPFZ Research building (for entrance see arrows) PhD Infection Biology Office and DEWIN, level 2 Seminar room 1420, ground floor 3: HBZ Building (Hans Borst Zentrum, J11) PhD Regenerative Science Office, level 2 Seminar room, ground floor 4: Main lecture hall building (F-N), Library, student secretary 5: Lecture halls Q, R 6: Lecture halls A-E