Hyalogic - Debra Eve Unlimited
Transcription
Hyalogic - Debra Eve Unlimited
product CATALOG WWW.HYALOGIC.COM • 866-318-8484 • [email protected] table OF CONTENTS our SCIENCE CONSULTANTS dr. karen brown During her 32-year career within the animal health industry, Dr. Karen K. Brown developed over 44 new products and obtained numerous patents. She was responsible for product research & process development for the first hyaluronic acid product manufactured via bacterial fermentation and holds the original patents. She has worked for 28 years in the area of hyaluronic acid. Dr. Brown received her BS from Washburn University, Topeka, KS in Chemistry and Biology, and her Ph.D. from Oklahoma State University in Biochemistry and Microbiology. She is a member of Sigma Xi and Phi Kappa Phi. dr. carol cooper about hyalogic 3 what is hyaluronic acid 5 featured products 7 joint health 9 hyalogical essentials 11 episilk 13 animal health 21 HA technical data 27 Dr. Carol A. Cooper has 25 years within the health industry, holding positions of increasing responsibility in various areas including product development and value management. She has worked in the area of hyaluronic acid for over 15 years. Dr. Cooper received her BS from Wayne State University, Detroit, MI, in Chemistry, and her Ph.D. from Wayne State in Biochemistry. She also graduated from the Executive MBA Program at the University of Pittsburgh and is a member of Phi Beta Kappa and Sigma Kappa Phi. a letter FROM OUR DIRECTOR OF SALES It’s hard to believe Hyalogic LLC is coming up on our 10th anniversery. Like most companies, Hyalogic started with an idea for a great product, and has an interesting story to tell. From the beginning, Hyalogic has been committed to understanding “what works.” To achieve this understanding, we literally gave the product away to gain insight from its users who coincidentally became Hyalogic’s first customers. To this day our customers provide us with invaluable input which helps to shape and guide Hyalogic on its roadmap. we demand of ourselves and others the highest ethical standards; resulting in our products and services to be of the highest quality. Our company focus is centered around 3 main items. First we are devoted to providing you with the finest natural products enhanced with hyaluronic acid for your health and personal care. Secondly, we constantly seek our customers’ satisfaction and feedback for new and improved products with the latest available science. And lastly, we strive to exceed your expectations regarding our customer service. We recognize trust is not easily earned and to that end In good health, We greatly appreciate the opportunity to present our company to you. We believe you will find our products to be physically beneficial for you, your family and your pets. Please contact us for any additional information you may need in evaluating your product selections. We will continue to push forward and dedicate ourselves to humanity’s quest for longer, healthier and happier lives. Todd McMullen 3 4 aboutHYALOGIC who we are. Hyalogic LLC is a global research-driven company that discovers, develops and markets a broad range of human and animal healthcare products We are a young and extremely dynamic company that has over 40 years of combined experience in healthcare products and services. We specialize in producing products that contain hyaluronic acid, a naturally occurring substance in the body that has numerous benefits. We have recently developed a patented product containing hyaluronic acid for overall joint and skin health. We pride ourselves in providing only the purest, highest molecular weight hyaluronic acid produced by an advanced biotechnology method. We also produce a full line of personal care products enriched with our premium hyaluronic acid. We are headquartered in Shawnee, KS, USA. We have an extensive network of distributors and dealers located throughout the United States and internationally. We have many healthcare professionals that we have partnered with to conduct cutting-edge research on the uses of hyaluronic acid and its benefits to the human body. the patent for our products. United States Patent #6,607,745 Ingestion of hyaluronic acid for joint function and health Abstract-The methods comprise the step of delivering by oral ingestion a nutritional supplement consisting essentially of an effective amount of hyaluronic acid, or a salt or digest thereof, and a food acceptable carrier, wherein the effective amount of hyaluronic acid, or a salt or digest thereof, is from about 0.1 .mu.g to about 400 .mu.g/ kg of body weight. Appl. No.: 860425 Filed: May 18, 2001 Current U.S. Class: 424/439; 424/400; 424/442; 424/451; 424/452; 514/825 Intern’l Class: A61K 047/00 Field of Search: 424/400,439,442,451,452 514/825 WE’RE PROUD MEMBERS OF 5 6 where HA is located in the body. EYES vitreous humor (hyaluronic acid) HAIR FOLLICLES healthy shaft dry shaft GUMS hair follicle connective tissue (hyaluronic acid and collagen THE SKIN Hyaluronic acid (HA) is a carbohydrate what isHYALURONIC more specifically a mucopolysaccharide occurring naturally throughout the human body. It can be several thousands of sugars (carbohydrates) long. When not bound to other molecules, it binds to water giving it a stiff viscous quality similar to “Jello”. This viscous gel is one of the most heavily researched substances in medicine today with thousands of clinical trials; mostly in the fields of orthopedics and eye surgery. Its function in the body is, amongst other things, to bind water and to lubricate movable parts of the body such as joints and muscles. Its consistency and tissue-friendliness allows it to be used in skin-care products as an excellent moisturizer. Hyaluronic acid is one of the most hydrophilic (water-loving) molecules in nature and can be described as “nature’s moisturizer”. hyaluronic acid and collagen epidermis hyaluronic acid and collagen JOINTS synovial fluid (hyaluronic acid) Through extensive research over the years, hyaluronic acid has yielded amazing results in various applications and locations through out the body. As well as joint cushioning and support, connective tissues, scalp tissue and hair follicles, eyes, gum tissues and skin have been known to benefit by hyaluronic acid supplementation. All of the products produced by Hyalogic contain this molecule. We strive to continue to offer you premium hyaluronic acid products that can truly lead the way to better over-all health, wellness and beauty for you and your animals. the story behind the hyaluronic acid molecule. ACID Hyaluronic acid (HA) is found naturally in almost every cell in the body and occurs in high concentrations in specific body locations. In each body location, it serves a different function. Unfortunately, HA also has a half-life (the time it takes for the molecule to get broken down and excreted from the body) of less than 3 days and possibly even as little as one day in the skin. For this reason, it is imperative that the body continually replenishes itself with HA. synovial fluid (hyaluronic acid) Our joints (like the elbows and knees) are surrounded by the synovial membrane which forms a capsule around the ends of the two articulating bones. This membrane secretes a liquid called the synovial fluid, a viscous fluid with the consistency of motor oil. It has many functions, but none more important than providing the elastic shock absorbing properties of the joint. Its second most important function in the joint is to carry nutrients to the cartilage and remove waste from the joint capsule. Normally these processes are carried out via the blood vessels, but because cartilage is without blood flow (avascular) the body relies on the hyaluronic acid to perform this function. the joint. HAND & BODY LOTION 7 SYNTHOVIAL SEVEN type: hand and body lotion description: This lotion enriched with hyaluronic acid leaves your skin silky smooth, and is great for all skin types. type: oral hyaluronic acid dietary supplement amount: 8 oz description: Synthovial Seven® is a pure oral solution that supplements the natural HA in your body. This miracle supplement supports healthy joint function as well as healthier, younger looking skin. ingredients: de-ionized water, emulsifying wax, grapeseed oil, caprylic/capric glycerides, soy wax, stearyl alcohol, avocado oil, jojoba oil, aloe vera, meadowfoam seed oil, sodium hyaluronate (hyaluronic acid), shea butter, vegetable glycerine, sorbitol, vitamin e, bees wax, methyl cellulose, guar gum, lactoperoxidase & glucose oxidase, allantoin. featuredPRODUCTS amount: 1 oz (30-day supply) ingredients: sodium hyaluronate (hyaluronic acid), normal saline HYALUN PRO 90 Supplement Facts Serving Size 1ml (Full Dropper) Serving Per Container 30 Amount Per Serving %DV* Hyaluronic acid 3mg* type: equine joint supplement *Daily Values (DV) Not Established. INACTIVE INGREDIENTS: NORMAL SALINE description: Hyalun® PRO is a pure oral solution that is designed for the high performance horse. This patented formula exhibits 30mg of hyaluronic acid per trigger pull. US patent # 6,607,745 amount: 90ml (30-day supply) 270ml (90-day supply) Amount Per Serving US patent # 6,607,745 testimonial The Moisture Mask with hyaluronic acid is nice. I can lay back and enjoy it’s cool, refreshing feel, and after about 25 minutes or so, I take it off, and my skin feels as smooth as a baby bottom! This is very good mask, I gave out one to all my friends this year in their gift baskets. Lorraine P. %DV* 30mg* Hyaluronic acid *Daily Values (DV) Not Established. INACTIVE INGREDIENTS: NORMAL SALINE, 1,2-propanediol, methylparaben, propylparaben ingredients: normal saline, sodium hyaluronate (hyaluronic acid), 1,2-propanediol, methylparaben and propylparaben what we recommend. These statements have not been evaluated by the Food and Drug Administration. These products are not inteded to diagnose, treat, cure or prevent any disease. Supplement Facts Serving Size 3ml (1 Full Trigger Squeeze) Serving Per Container 90 8 HYLARUB 9 As we age, the body’s production of both the quality and quantity of HA declines. SYNTHOVIAL SEVEN 10 type: topical cream description: A pleasant smelling cream which uses patented ingredients to help soothe, moisturize and support healthy joints and muscles for an active lifestyle. Hyaluronic acid (HA) and cetyl myristoleate (CMO) for their ability to soothe have been combined in a unique, natural preservative base with no harmful parabens added. amount: 6 oz. tube type: oral hyaluronic acid dietary supplement ingredients: water, cetyl myristate, cetyl oeate, emu oil, emulsifying wax, glycerin, stearic acid, cetyl alcohol, l-arginine, peppermint oil, sodium hyaluronate (hyaluronic acid), lactoperoxidase, glucose oxidase, glucose, capsaicin. description: Synthovial Seven is a pure oral solution that supplements the natural HA in your body. This miracle supplement supports healthy joint function as well as healthier, younger looking skin. ® US patent # 5,888,984 HYLASOAK amount: 1 oz (30-day supply) ingredients: sodium hyaluronate (hyaluronic acid), normal saline Supplement Facts Serving Size 1ml (Full Dropper) Serving Per Container 30 Amount Per Serving %DV* Hyaluronic acid 3mg* samples available type: muscle and joint soak *Daily Values (DV) Not Established. INACTIVE INGREDIENTS: NORMAL SALINE Uses per pouch (by scoop amount) US patent # 6,607,745 jointHEALTH Foot bath 32 Bathtub 16 Jacuzzi 8 description: HylaSoak is a powdered bath soak that uses hyaluronic acid (HA) as well as jojoba oil, and other natural oils that nurture your skin and joints. amount: 4 oz resealable pouch ingredients: citric acid (monohydrate), sodium bicarbonate (baking soda), sodium hyaluronate (hyaluronic acid), decyl poly glucose, jojoba oil, polysorbate 20, methyl salicylate/wintergreen oil, spearmint oil, peppermint oil, clove bud oil, apple spice essence the HA solution for your joints. testimonial I shop at Nature’s Pantry in La Grande, Oregon where I was introduced to Synthovial Seven®. It was recommended to me because I was looking for something to help support my knees. I believe that Synthovial Seven® has helped me in that area. Although your product has helped in this area, the really impressive testimony is what it has done and continues to do for my gums and teeth. Thank you for your great product! Pat S. These statements have not been evaluated by the Food and Drug Administration. These products are not inteded to diagnose, treat, cure or prevent any disease. 11 DR. JOHN’S FORMULA TOOTH GEL type: tooth gel 70% of the fluid in your eyes is HA. Dr. John’s Formula is description: enriched with hyaluronic acid and xylitol for healthier gums and teeth. All the benefits of a natural oral care formula with the logical addition of HA for gum health. HYLAVISION type: oral vision dietary supplement hyalogicESSENTIALS description: Aging, increased exposure to harmful environmental factors, and the lack of the nutrients that support healthy eyes in our daily diet have caused an increase in eyerelated health issues. HylaVision is uniquely formulated with HA and other essential ingredients we need to support healthy eyes and vision. amount: 4.58 oz tube ingredients: sodium hyaluronate (hyaluronic acid), sorbitol, water, hydrated silica, xylitol, glycerin, zinc citrate trihydrate, sodium lauroyl sarcosinate, peppermint oil, xanthum gum HYLAMIST amount: 120 capsules (2 month supply) type: nasal mist HylaMist is hyaluronic description: acid for nasal usage, designed to sooth and moisturize noses. vitreous humor (hyaluronic acid) amount: 1.5 fl. oz bottle ingredients: purified water, sodium chloride, sodium hyaluronate (hyaluronic acid), grapefruit seed extract the essentials to your life. hylavision FACTS These statements have not been evaluated by the Food and Drug Administration. These products are not inteded to diagnose, treat, cure or prevent any disease. testimonial I am not good at writing, but I am just so thrilled with the Episilk Face Cream, I had to write something. I don’t think I’ve ever tried anything that has had such amazing results. Diane L. 12 13 14 HA binds 1000 times its weight with water. LIP BALM type: lip balm Our premium lip description: balm is enriched with hyaluronic acid (HA); using all-natural ingredients and has no harmful parabens. Formulated to moisten and plumpen lips. HAND & BODY LOTION type: hand and body lotion description: This lotion enriched with hyaluronic acid leaves your skin silky smooth, and is great for all skin types. amount: 8 oz bottle ingredients: vegetable oil, aloe, beeswax, isopropyl myristate, cocoa butter, shea butter, sodium hyaluronate (hyaluronic acid), biovert c ingredients: de-ionized water, emulsifying wax, grapeseed oil, caprylic/capric glycerides, soy wax, stearyl alcohol, avocado oil, jojoba oil, aloe vera, meadowfoam seed oil, sodium hyaluronate (hyaluronic acid), shea butter, vegetable glycerine, sorbitol, vitamin e, bees wax, methyl cellulose, guar gum, lactoperoxidase & glucose oxidase, allantoin. amount: .5 oz jar FACIAL CREAM SHAMPOO & CONDITIONER type: premium face cream episilk HA personal care. description: Our premium facial cream combines HA with several other allnatural moisturizers, while not using any harmful parabens. Use this product daily to moisturize and hydrate your face. amount: 2 oz jar ingredients: de-ionized water, emulsifying wax, grapeseed oil, caprylic/capric glycerides, soy wax, stearyl alcohol, avocado oil, jojoba oil, aloe vera, meadowfoam seed oil, sodium hyaluronate (hyaluronic acid), shea butter, vegetable glycerine, sorbitol, vitamin e, bees wax, methyl cellulose, guar gum, lactoperoxidase & glucose oxidase, allantoin. type: shampoo and conditioner description: Our hyaluronic acid enriched shampoo and conditioner help to refresh and revive your scalp and hair with mild natural ingredients and no harmful preservatives. A healthy, nourished scalp can help provide fuller, healthier hair amount: 8 oz bottle shampoo ingredients: water, PEG 80, sorbitan laurate, sodium tricedeth sulphate, PEG 150 stearate, cocamidopropyl hydroxysultaine, disodium lauroamphodacetate, sodium hyaluronate (hyaluronic acid), aloe vera, glycerin, chamomile extract, wheat germ oil, hydrolyzed wheat protein, citirc acid, lactoperoxidase, glucose oxidase, glucose. conditioner ingredients: water, cetyl alcohol, stearic acid, sodium hyaluronate (hyaluronic acid), behentrimonium chloride, glycerine, castorisostearate succinate, pearlescent lactoperoxidase, glucose oxidase, tea, dimethicone 15 16 FACIAL SCRUB MOISTURE MASK type: exfoliating scrub type: cloth spa mask description: Our moisture mask is a full, esthetician tested facial mask that contains hyaluronic acid and aloe to moisturize your skin, and soften wrinkles. description: Using Exfo-Amber, this facial scrub lightly exfoliates your face using hyaluronic acid and other natural ingredients to moisturize and soothe your skin while not containing any harmful parabens. amount: 4.58 oz tube amount: 1 mask (single use) ingredients: sodium hyaluronate (hyaluronic acid), aloe me200 hydro, lemon extract, propylene glycol, methylparaben, phenoxyethanol, water CELLULITE CREAM type: cellulite cream (5 pack display box available) episilk HA personal care. ingredients: water, jojoba oil, cetearyl olivate, sorbitan olivate, water, decyl glucoside, sodium lauroyl lactylate, glycol stearate, ceteartyl olivate, sorbitan olivate, pinus resin, glycerin, hydrolyzed caesalpinia spinosa, caesalpinia spinosa gum, olive squalane, organic corn starch, cetyl alcohol, sodium hyaluronate (hyaluronic acid), natural peppermint oil, glucose oxidase and lactoperoxidase HA is the most water-loving molecule known today. description: Utilizing Regu®-Stretch, Regu®-Shape, Regu®Slim, and caffeine as supportive ingredients, our cellulite cream firms and tones your skin while using hyaluronic acid to soothe and moisturize your skin. This cream contains all-natural ingredients while not containing any harmful parbens. amount: 4.58 oz tube ingredients: water, jojoba oil, cetearyl olivate, sorbitan olivate, caffeine, paullinia cupana seed extract, carnitine, cysteic acid, pantethine sulfonate, maltodextrin, panthenol, marrubium vulgare extract, palmitoyl tripeptide-5, glycerin, isomerized linoleic acid, lecithin, polysorbate 80, sodium hyaluronate (hyaluronic acid), xanthan gum, glucose oxidase and lactoperoxidase Regu®-Stretch is an innovative ingredient, comprised of a peptide, a vitamin and organic marrubium extract. It protects stretched skin structure and diminishes stretch marks and skin blemishes. Regu®-Shape is made from a standardized amount of conjugated linoleic acid (CLA), which is currently being used in dietary supplements formulated to assist the body with weight management. Regu®-Slim is a unique patented, multiactive re-shaping and smoothing complex. Regu®-Slim is designed to smooth and tighten skin, optimize fitness efforts to reshape the body, and help restore the skin’s contours. 17 18 Each of our serums are: FRS SERUM (facial relax) spa tested • paraben free • super moisturizing • great on all skin types Anti-wrinkle test type: facial serum PHA SERUM (pure hyaluronic acid) description: This facial serum uses the combination of hyaluronic acid and Argireline®, a hexapeptide-8 known to reduce the depth of expression lines and wrinkles especially in the forehead and around the eyes. type: facial serum description: The PHA Serum is an intensely hydrating serum that rejuvenates skin’s suppleness and elasticity while smoothing fine lines and wrinkles. 50% of the HA found in the body is found in the skin layers of the dermis and epidermis. HA keeps skin hydrated and provides nourishment transport to the cells. With age, the ability of skin to produce HA decreases leaving the skin wrinkled. amount: 1 oz episilkSERUMS IFL SERUM (instant facelift) Research results published by Lipotec. Argireline® is a registered trademark of Lipotec S.A. amount: 1 oz ingredients: water, argireline, vegetable glycerin, sodium hyaluronate (hyaluronic acid), xanthan gum, aloe vera juice, lactoperoxidase, glucose oxidase, glucose, wheat extract, asian ginseng, echinacea. ingredients: water, sodium hyaluronate (hyaluronic acid) Pepha-Tight® studies Skin topography analyses were performed by obtaining silicon imprints from around the eyes of 10 healthy women volunteers. Skin topography images fro m the three dimensional reconstruction of optical sections are shown in the figure (before use; and after 30 days with twice a day applications). The depth of the wrinkle decreased an average of 27% with maximum values between 50 and 60%. coQ10 studies WINNER Q10 SERUM (coQ10 age defense) type: facial serum The efficacy of Pepha-Tight® was performed in an in vivo study with 30 volunteers during 2 weeks. The figure shows the statements of the panelists reporting very good/good tightening effect. description: This facial serum uses the combination of hyaluronic acid and Pepha®-Tight, a unique algae extract known for instant tightening effect. This extract has the ability to smooth fine wrinkles as well as forming a protective shield against oxidative stress. amount: 1 oz The immediate efficacy of PephaTight® was evalulated in vivo with 20 volunteers applying a test gel containing 5% Pepha-Tight®. Research results published by Pentapharm. Pepha-Tight® is a registered trademark of Pentapharm professional spa products. ingredients: water, Pepha®-Tight (pullulan, algae extract), sodium hyaluronate (hyaluronic acid), zinc glyconate, xanthan gum, vegetable glycerin, vitamin A, citric acid, glucose, lactoperoxidase, glucose oxidase type: facial serum “Photoaging is the presence of deep wrinkles caused by UVA irradiation. This study was done over a 6 month period and examined the effects of CoQ10 on 20 elderly volunteers, once daily around the eyes for 6 months. There was a 27% reduction in the mean peak to valley depth of the skin”… “Using microtopgraphy, the reduction in skin wrinkles could be measured and charted.” From BioFactors 9 (1999) 371-378, IOS Press CoEnzyme Q10, a cutaneous antioxidant and energizer - U. Hopper et al. description: This facial serum uses the combination of hyaluronic acid and coenzyme q10, designed to hydrate, nourish and rejuvenate your skin. amount: 1 oz ingredients: water, jojoba oil, sodium hyaluronate (hyaluronic acid), coenzyme Q10, hydrolyzed wheat protein, vegetable glycerin, ascorbic acid (vitamin C), glucose, lactoperoxidase, glucose oxidase 19 DCL SERUM (dark circle lightening) SERUM DISPLAY Eyeseryl® studies type: facial serum type: store front display description: This facial serum is an effective combination of HA, Eyeseryl®, and Regu®-Age, designed to hydrate your skin and lighten the appearance of dark eye circles. amount: 20 description: A clear plexiglass display that is designed to maximize your serum sales. This display is a great way to inform your customers as well as sampling our serums. Results of Eyeseryl ® after a period of 15 days. Regu®-Age studies 1 oz Results of Regu®-Age after a period of 8 weeks. ingredients: water, vegetable glycerin, Acetyl Tetrapeptide-5, hydrolyzed rice bran, soy protein, oxido reductases, sodium hyaluronate (hyaluronic acid), xanthan gum, chamomile extract, green tea extract, glucose, glucose oxidase, lactoperoxidase. contents 24 Episilk serums (4 of each) 1 custom plexiglass display 6 testers (1 for each serum) 100 mini catalogs ASL SERUM Gigawhite™ studies episilkSERUMS (age spot lightening) +15.3% -24% Measurement of the reduction of age spots color intensity -8.6% -28.6% Gigawhite™ shows significant lightening activity after 12 weeks of treatment (Asian skin) with a 5% Gigawhite™ solution, while not observing any particular irritation. SERUM SAMPLE PACK type: facial serum description: This facial serum is an effective combination of HA and Gigawhite™ designed to hydrate and soothe your skin while lightening and toning age spots. type: facial serum sampler description: This trial size variety pack includes one 3 ml sample of each of our six facial serums. Discover which one or combination works best for you. amount: 1 oz At a concentration of 5% and after 12 weeks, Gigawhite™ shows significant reduction of age-spots color intensity. Research results published by Alpaflor and Pentapharm. ingredients: water, vegetable glycerin, malva sylvestris (mallow extract), primula veris extract, alchemilla vulgaris extract, melissa officinalis extract, achillea milefolium extract, sodium hyaluronate (hyaluronic acid), xanthan gum, silicate, chamomile extract, green tea extract, glucose, glucose oxidase, lactoperoxidase amount: (6) 3 ml bottles professional spa products. testimonial Hi, what an amazing product you have with your topical serum. I’ve been using it for about four weeks and have noticed that my fine lines all but disappear and the deeper lines around my mouth and my complexion is much lighter. I use a drop in the morning and one at bedtime, I am 57 years old, so a perfect face to try this serum on. I have tried many products to lessen my wrinkles, but none compare with your product. Lee N. HYALUN 30 21 22 type: equine joint supplement description: Hyalun® 30 is a pure oral solution that provides 5mg of hyaluronic acid per administration. One dropper-a-day is all it takes to give your horse’s joints the support they need. audited member HYALUN GEL type: pre and post event booster description: Hyalun® Gel is a highly conentrated hyaluronic acid gel that is designed to supply your horse with extra HA before or after an event or workout. amount: 1 oz (30-day supply) ingredients: normal saline, sodium hyaluronate (hyaluronic acid) amount: 30cc syringe (3-full administrations) Supplement Facts Serving Size 1ml (Full Dropper) Serving Per Container 30 Amount Per Serving %DV* Hyaluronic Acid 5mg* ingredients: normal saline, sodium hyaluronate (hyaluronic acid) *Daily Values (DV) Not Established. INACTIVE INGREDIENTS: NORMAL SALINE Supplement Facts Serving Size 10cc (1/3 of syringe) Serving Per Container 3 HYALUNRUB US patent # 6,607,745 HYALUN 90 Amount Per Serving Hyaluronic Acid %DV* 30mg* *Daily Values (DV) Not Established. INACTIVE INGREDIENTS: NORMAL SALINE US patent # 6,607,745 type: equine joint supplement type: equine joint cream hyalun description: Hyalun® 90 is a pure oral solution that privdes 5mg of hyaluronic acid per administration. description: Hyalun®Rub is a pleasant smelling cream which uses patented ingredients to help sooth, moisturize and maintain healthy equine joints and muscles. amount: 180ml (90-day supply) ingredients: normal saline, sodium hyaluronate (hyaluronic acid) amount: 6 oz. tube Supplement Facts ingredients: water, cetyl myristate, cetyl oeate, emu oil, emulsifying wax, glycerin, stearic acid, cetyl alcohol, l-arginine, peppermint oil, sodium hyaluronate (hyaluronic acid), lactoperoxidase, glucose oxidase, glucose, capsaicin. Serving Size 2ml (1 Full Trigger Squeeze) Serving Per Container 90 Amount Per Serving %DV* 5mg* Hyaluronic Acid *Daily Values (DV) Not Established. INACTIVE INGREDIENTS: NORMAL SALINE US patent # 6,607,745 US patent # 5,888,984 support for your horse. testimonial It is the easiest and most effective product I have found on the market today, and I know my horse, Diamond Daisey, has found Hyalun to help support her joints over the years. She has been a buggy horse for twelve of her fourteen years on earth and as she gets older, the buggy work gets harder on her than ever before. Thanks to your Hyalun product, she is back at it! One month’s time has seen super results, and we have since started all our horses on the product as a maintenance regiment! Jay M. 23 24 audited member HYALUN PRO 30 & PRO 90 type: equine joint supplement description: Hyalun® PRO GEL is a highly conentrated hyaluronic acid gel that is designed to supply your horse with extra HA before or after an event or workout. hyalun pro amount: 30cc syringe (3-full administrations) description: Hyalun® PRO is a pure oral solution that is designed for the high performance horse. This patented formula exhibits 30mg of hyaluronic acid per trigger pull. ingredients: normal saline, sodium hyaluronate (hyaluronic acid), 1,2-propanediol, methylparaben and propylparaben Supplement Facts Serving Size 10cc (1/3 of syringe) Serving Per Container 3 Amount Per Serving Hyaluronic acid amount: 90ml (30-day supply) 270ml (90-day supply) US patent # 6,607,745 hyalun VS hyalun PRO US patent # 6,607,745 Serving Size 3ml (1 Full Trigger Squeeze) Serving Per Container 30 Amount Per Serving Hyalun® PRO was designed out of the need for a stronger amount of hyaluronic acid (HA) for horses that are pushed to the limit either through work or competition. We have continued to work with our customers, distributors and endorsees for thoughts and ideas for better products for horses. As a result of these internal and external recommendations we developed Hyalun® PRO. PRO FACTS 90 Supplement Facts %DV* 30mg* Hyaluronic acid *Daily Values (DV) Not Established. INACTIVE INGREDIENTS: NORMAL SALINE, 1,2-propanediol, methylparaben, propylparaben On average, eighty percent of the horses in use today are used in recreational activities or low-impact labor. The remaining twenty percent of horses are involved in either some form of competition or a strenuous work environment. Hyalun® PRO is designed to fulfill the joint maintenance needs of the physical demands placed on the horses in this twenty percent. Hyalun® PRO is a stronger, more concentrated version of our original Hyalun® product. For those of you that have enjoyed our Hyalun® product line, our original Hyalun® products are still available at your favorite retailers. As you evaluate your horse’s daily schedule, you can determine if Hyalun® or Hyalun® PRO is best suited for your horse’s joint health maintenance. Supplement Facts Serving Size 3ml (1 Full Trigger Squeeze) Serving Per Container 90 Amount Per Serving %DV* 100mg* *Daily Values (DV) Not Established. INACTIVE INGREDIENTS: NORMAL SALINE, 1,2-propanediol, methylparaben, propylparaben ingredients: normal saline, sodium hyaluronate (hyaluronic acid), 1,2-propanediol, methylparaben and propylparaben PRO FACTS 30 HYALUN PRO GEL type: equine joint supplement %DV* 30mg* Hyaluronic acid *Daily Values (DV) Not Established. INACTIVE INGREDIENTS: NORMAL SALINE, 1,2-propanediol, methylparaben, propylparaben Hyalun® PRO GEL, a pre and post event booster gel is available as you are preparing for or coming home from an event where your horse can benefit from additional HA. joint support with a competitive edge. team HYALUN PRO testimonials ANDREA FAPPANI BOB AVILA CLINT SCHELLER CRAIG JOHNSON JAKE BARNES JR REICHERT KERRY KUHN MATT GAINES SHERI ESTRADA SHERRY CERVI TROY COMPTON WESLEY GAYLEAN We have had 2 barrel horses on the Hyalun® PRO for about 30 days and we are starting to see effects. We are seeing quicker recoveries after intense work outs. Mike and Kim H. I know with Hyalun I am doing the best I can for my horse’s joints everyday. Bob Avila (NRCHA and NRHA Futurity Champion) 25 26 type: equine muscle supplement EQUIDURANCE audited member equinePERFORMANCE description: EquiDurance is a liquid equine supplement that helps to support muscle performance, power output, and normal recovery time after strenuous activity. amount: 270ml (90-day supply) ingredients: normal saline, sodium hyaluronate (hyaluronic acid), beta-alanine, l-carnosine 1,2-propanediol, methylparaben and propylparaben Supplement Facts Serving Size 3ml (1 Full Trigger Squeeze) Serving Per Container 90 Amount Per Serving %DV* 1000mg* Beta-alanine 150mg* L-carnosine 10mg* Hyaluronic acid *Daily Values (DV) Not Established. INACTIVE INGREDIENTS: NORMAL SALINE, 1,2-propanediol, methylparaben, propylparaben type: pet joint supplement description: HyaFlex™ is a pure, patented oral hyaluronic acid solution that has been formulated for cats and dogs of all sizes. BETA-ALANINE This product contains a ground-breaking new ingredient called beta-alanine. Beta-alanine is the only naturally occurring beta-amino acid that raises muscle carnosine levels by, on average, 80% after supplementing. We know carnosine is instrumental in maximizing muscular power output levels, muscle recovery periods, and normal lactic acid levels. type: equine wound care kit description: This wound care kit uses glycerin-based hydrogel pads and HA moisturizing to draw discharge from the wound, while not allowing the wound to dry out. Thus allowing for less frequent bandage changes which can increase comfort for the horse. keep your horse at peak performance. amount: 2 (4”x4”) gel pads 3g of drying powder 1 oz tube of collagen ingredients: normal saline, sodium hyaluronate (hyaluronic acid) Supplement Facts hyaflex EQUILOGIC WOUND HEALING SYSTEM amount: 1 oz (30-day supply) Serving Size 1ml (Full Dropper) Serving Per Container 30 Amount Per Serving %DV* Hyaluronic acid 2mg* *Daily Values (DV) Not Established. INACTIVE INGREDIENTS: NORMAL SALINE US patent # 6,607,745 joint support for cats and dogs. testimonial I was contacted a little over a month ago by a man about HyaFlex. I run a Lab rescue and Club here in Utah, and I was sent 3 samples. I kept one for a rescued Lab, gave one to my sister-in-law who has a senior Collie, and one to a friend at a shelter who has a Mastiff; all three have the same joint concerns. My Lab is now able to run and play like my younger dog. I will be advertising your product to all my club members, adopters, and friends! Thank you so much!!! Barbi C. ha Advantages of liquid HA vs. powder or capsules TECHNICAL DATA All of the atributes and characteristics of hyaluronic acid explained in this catalog are applicable to all mammals; more specificially dogs, cats, horses, and humans. All of our HA supplements support healthy functions for all of the recipients listed above. What is the Chemical Structure of HA? It is naturally produced in the mammal body and is chemically classified as a Glycosaminoglycan. In the body, HA always presents itself as a high molecular weight and large molecular volume molecule. The molecule is made up of a repetitive sequence of two modified simple sugars, one called glucuronic acid and the other N acetyl glucosamine. These compounds are both negatively charged and when put together they repel. This which produces an exceptionally elongated molecule (high molecular weight). HA molecules that are long and large in size produce a high viscosity which, in turn, provides a lubrication and shock absorbing effect. Because of this, it resists compression and allows the joints and skin to bear weight, withstand tension, and endure abuses, such as physical trauma and abrasion that no other tissue in the body could withstand. Properties • Odorless, tasteless, colorless • pH Range: 6.5 – 7.5 • Shelf life: 2 years • High molecular weight: 2, 900,000 Daltons molecular weight Where can it be found in the body? Bones/cartilage Hyaluronic acid is found in all bones and cartilage structures throughout the mammal’s body. Both of these structures provide a resilient rigidity to the structure of the body. HA is especially found in various forms of cartilage but none more than the hyaline cartilage. As you’ve probably guessed it, hyaline is short for hyaluronic acid. Tendons and ligaments/connective tissue Connective tissue is found everywhere in the body. It does much more than connect body parts; it has many forms and functions. Its major functions include binding, support, protection, and insulation. One such example of connective tissue is the cordlike structures that connect muscle to bone (tendons) and bone to bone (ligaments). In all connective tissue there are three structural elements. They are ground substance (hyaluronic acid), stretchy fibers (collagen and elastin) and a fundamental cell type. Whereas all other primary tissues in the body are composed mainly of living cells, connective tissues are composed largely of a nonliving ground substance (hyaluronic acid) which separates and cushions the living cells of the connective tissue. The separation and cushioning allow the tissue to bear weight, withstand great tension and endure abuses that no other body tissue could. All of this is made possible because of the presence of the HA and its ability to form the gelatinous ground substance fluid. Scalp tissue and hair follicles Structurally the scalp is identical to the skin tissue located throughout the body except it also contains about 100,000 hair follicles that give rise to hair. Actually the hair and the hair follicle are a derivative of skin tissue. There are two distinctive skin layers: the epidermis (outer layer) which gives rise to the protective shield of the body, and the dermal layer (deep layer) which makes up the bulk of the skin and is where the hair follicle is located. This dermal layer is composed of connective tissue that provides support, and nourishes and hydrates the deep layers of the scalp with its gelatinous, fluid like characteristics. The result is healthy, lustrous hair and a moisturized scalp. Again, all of this is made possible because of the presence of HA in the scalp tissue and its ability to form this fluid and hold water. Lips The lips are a core of skeletal muscle covered by skin tissue. The dermal layer of the lips is composed primarily of connective tissue and its their components, hyaluronic acid and collagen, that give the structure (shape) and plumpness to the lips. The hyaluronic acid binds to water creating a gelatinous fluid that hydrates the surrounding tissue and keeps the collagen (responsible for keeping the skin tight) nourished and healthy. The result is healthy, well hydrated and plump lips that are well protected from the environment. Vision Hyaluronic acid is highly concentrated inside the eyeball. The fluid inside the eye, called the vitreous humor, is composed almost completely of hyaluronic acid. The HA gives the fluid inside the eye a viscous gel like property. This gel acts as a shock absorber for the eye and also serves to transport nutrients into the eye. Eye surgeons inject HA directly into the eye to help maintain its shape during surgery. It has been said that after the fifth decade of life, our eyes stop producing the much needed HA resulting in various eye concerns. Gum tissue (connective tissue) The gums (gingivoe) are composed of dense fibrous connective tissue (ligaments) which secure the teeth to the aveloar bone (jaw bone). Once again, connective tissue is composed of a fibrous tissue surrounded by hyaluronic acid (extra-cellular matrix). Without the hyaluronic acid, the gum tissue becomes unhealthy. If the HA is present it helps to provide the tensile strength of the ligaments that secure the tooth in place by providing hydration and nourishment. The result is healthy gums. Skin Although HA can be found naturally in almost every cell in the body, it is found in the greatest concentrations, almost 50%, in the skin tissue. It is found in both the deep underlying dermal areas as well as the visible epidermal top layers. Young skin remains smooth, elastic and healthy with the help of the large amounts of HA that it contains. The HA provides continuous moisture to the skin by binding up to 1000 times its weight in water. With age, the ability of the skin to produce HA decreases, leaving the skin unhealthy and wrinkled. ECM (ground substance) The extracellular matrix (ECM) is a gelatinous fluid that surrounds almost all living cells and is essential to life. It gives structure and support to the body: without it, we would just be trillions of cells without shape or function. It is essentially the mortar between the bricks. The skin, bones, cartilage, tendons and ligaments are examples of where the ECM is located in the body. The ECM is composed of material (fibrous elements) called elastin and collagen surrounded by HA a gelatinous substance (hyaluronic acid). HA’s role in the ECM is to prevent the stretchy fibers in the body from overstretching and drying out by continually bathing them in this nutritious water-based gelatinous fluid. It also serves as a wonderful medium through which nutrients and waste are transported to and from the cells of these structures. This fluid would not exist if it was not for the ability of the HA molecule to bind up to 1000 times its weight in water. Synovial fluid The joints (like the elbows and knees) are surrounded by the synovial membrane which forms a capsule around the ends of the two articulating bones. This membrane secretes a liquid called the synovial fluid, a viscous fluid with the consistency of motor oil. It has many functions, but none more important than providing the elastic shock absorbing properties of the joint. Its second most important function in the joint is to carry nutrients to the cartilage and remove waste from the joint capsule. Normally these processes are carried out via the blood vessels but because cartilage is without blood flow (avascular) the body relies on the hyaluronic acid to perform this function. Sources of hyaluronic acid Liquid solutions by nature have always been more readily absorbed into the body. This remains true when dealing with the HA molecule. The HA molecule has the ability to bind up to 1000 times its weight in water. If the HA molecule could not do this, it could not perform all the life supporting functions in the body that it is known for. The process of binding the HA to water is very lengthy. The HA molecule needs adequate time to interact with the water, much like a sponge, thus allowing the HA to fully saturate. In fact, it can take up to 2 days for the molecule to become fully bound to water. If insufficient time is not provided, the HA does not fully bind and never performs. It is for this reason that liquid HA in an already bound liquid form is superior. Liquid HA is also far more likely to move through the intestinal wall into the bloodstream than a powder or dry form. of HA. The result is that a large amount of non-liquid HA will never get absorbed and will generally be excreted as waste. High molecular weight ha advantages 1. Most sodium hyaluronate products have comparatively low molecular weight levels, well below the optimum range for an effective amount. Our hyaluronic acid has a molecular weight that is up to six times heavier than the low molecularweight competitors.This provides joint, skin, eye, and hair support and benefit. 4. Smaller dosage is required for effective benefit. 5. Longer residual life in the anatomy. 6. High molecular weight HA is readily absorbed because of its rope like appearance. Feeding the large HA molecule through the pores of the digestive tract is like feeding a rope down a well. HMW HA is an intact molecule, but is still very small in comparison to the pores of the digestive tract. 7. According to a recent study by researchers Smith and Goush, they suggested that the body patterns its HA production based upon what kind of HA is present in the body. This most likely explains the reason why the body cannot rebuild the necessary high molecular weight HA from low molecular weight HA already present in the body. 2. Its high molecular weight is what gives hyaluronic acid its superior elasticity. Upon impact, the long, intertwined HMW sodium hyaluronate molecules compress to absorb the impact and then spring back to their previous shape, ready to help absorb the next shock. Lower molecular-weight cannot compress and rebound with the same high efficiency. 3. Higher molecular weight HA is highly viscous, similar to motor oil. It is the larger molecule that allows for more water binding capacity and more lubrication. faq FREQUENTLY ASKED QUESTIONS What results do people report from using your product? We receive numerous favorable comments from people about the results they are experiencing. We have compiled a representative sample of these unsolicited testimonials on our website at www.hyalogic.com/testimonials.htm. Are these products safe? Since hyaluronic acid occurs naturally in the body, taking small amounts of HA in our products should be of no health concern. In fact, hyaluronic acid is non-toxic at doses a hundred times the recommended daily serving of Synthovial Seven®. Where does your hyaluronic acid come from? Our acid comes from non-animal sourced bacterial fermentation. The weight of the molecule directly influences its “moisture-binding” capability, and Synthovial Seven® is the highest molecular weight HA on the market, which explains the phenomenal results we have experienced. Animal derived • Rooster cockscomb • Bovine vitreous humor • Chicken cartilage • Collagen Can your products be taken with glucosamine and chondroitin? If you are already taking other supplements for joint support, taking Synthovial Seven® can supplement the benefits by assisting to provide joint and cartilage support. While HA is in the “family” of glycosaminoglycans as “glucosamine”, it is unique in its ability, and will often provide benefit where glucosamine and chondroitin have failed to do so. The synergistic action of all of these molecules is of course, the optimal way to address joint concerns, as they all represent the materials that comprise the matrix of our joint tissues. Comparison of non-animal vs. animal Bacterial fermentation is the only non-animal source of hyaluronic acid. The ingredient is non-GMO [genetically modified organism] and vegan friendly. It is also the only form that is used as an oral, a topical and as an injectable. Bacterial fermentation is available in a higher molecular weight form only, the method of choice for applications utilizing needles. This method produces a pure HA molecule free of contaminants. Do I need to take these supplement with food? Synthovial Seven® is easily tolerated with or without food. We recommend taking Synthovial Seven® first thing in the morning (this is a good way of getting in the habit of taking it everyday). It is only necessary to take it once a day, although many people take it in the morning and again at bedtime and report excellent results. As with any nutritional supplement, it is important to be consistent and take it every day. Problems with animal source HA • Allows the inadvertent contamination with animal inherent, bacteria, virus, and prions, (proteinaceous infectious particles), potentially responsible for certain human diseases. • Can only produce low molecular weight HA. • Sufficient animals must be available to provide HA which is certainly not animal friendly. • These sources are of concern when injected into the body due to the risk of infections by contamination. • Cannot be displayed in a liquid form because the foreign particulate cannot be properly filtered, leaving an unappealing appearance. Usually this source is placed into a capsule, powder or soft gel to mask the impurities and hide the contaminants. Do doctors use hyaluronic acid? The answer is yes. Most of the work has been done in the field of orthopedics, eye surgery and cosmetic surgery. Non-animal derived • Bacterial fermentation (our products) As the body ages, the HMW HA gets broke down into low molecular weight HA and the viscosity decreases considerably. Lubrication of the joints and skin is lost. How long has HA been used? Hyaluronic acid was first used commercially in 1942 when Endre Balazs applied for a patent to use it as a substitute for egg white in bakery products. He went on to become the leading expert on HA, and made the majority of discoveries concerning HA. Hyaluronic acid has been used for many applications ever since. How is your hyaluronic acid absorbed, and where does it go? (The following is an exerpt from a research study conducted on HA.) Washing- ton. D.C., April 18, 2004 – A consortium of scientists released clinical research results about oral delivery of radiolabeled Hyaluronan (HA) and its ability to be taken up by joints. Dr. Alex Schauss, Director of AIBMR, presented the findings at the 2004 Experimental Biology conference, conducted by the Federation of American Societies for Experimental Biology. Hyaluronan has been used for years in veterinary and human medicine as an injection to replace lost joint fluid. “This is the first time hyaluronic acid has been reported to be absorbed orally, which paves the way for HA dietary supplements to be introduced and deliver on anti-aging and joint health promises,” said Dr. Luke Bucci, Ph.D., Vice President of Research for Weider Nutrition International. Until now, there was no data on pharmacokinetics after oral intake and the medicinal use of hyaluronic acid was limited to injections or topical applications. The results of this study, which examined the absorption, excretion and distribution of radiolabeled HA after a single oral administration in Wistar rats and Beagle dogs, demonstrated that HA is absorbed and distributed to organs and joints after a single oral administration. Are your products patented? We currently operate under two patents: U.S. Patent Number 6,607,704 for methods for improved joint function and health; and U.S. Patent 5,888,984 for an invention of a topical composition containing complex carbohydrates (hyaluronic acid) and essential oils to support healthy skin and joint function. 29 30 PRODUCT SUPPORT MATERIAL ® HA THE ANTI-AGING ANSWER We are happy to support our store owners with any and all the material they need to promote our products. Available upon request, we have product panel cards that outlines the respective product’s information. If a customer requires more technical information, we do have product tech sheets complete with frequently asked questions. Panel cards that are available: • Synthovial Seven® panel card • HylaRub® panel card • HyaFlex™ panel card • Hyalun® PRO panel card type: book support description: A book by Dr. Chris Meletis, ND and Dave Roussett explores the many uses of hyaluronic acid in great detail. This is a great way to gain a good understanding of the role HA plays in overall health. informational audio cd’s on hyaluronic acid and other great ingredients available by Audio Nutrient Digest™ PRODUCT CATALOGS ppani® AndreaendFa s on Hyalun dep Shouldn’t you? We offer product catalogs for your customers; available upon request. These catalogs give consumers information on each of the products and their uses. Catalogs that are available: • Mini product catalog • Mini serum catalog • Mini Hyalun® equine catalog we help you sell our products. see our products in THESE MAGAZINES ask one of EXPERTS our Monday through Friday; 9-5 CST If you have any more questions concerning our products, our research, or just hyaluronic acid in general, please feel free to contact our office via phone or email at anytime. Our knowledgable sales team will be happy to answer any and every question that you may have. If you have never tried our products, give us a call and request your FREE SAMPLE KIT complete with information about Hyalogic and hyaluronic acid. www.hyalogic.com [email protected] toll-free: 866-318-8484 proudly marketed and promoted at 4015 Bonner Industrial Dr. Shawnee, KS 66226, USA website: www.hyalogic.com toll-free: 866-318-8484 Proudly manufactured in the USA