Patterns of viral infection

cytocidal (lytic) infections
outcome: cell death
(
ytocidal)
long lasting (perzistent)
outcome: continuous viral presence in the infected cell; active
replication or persistence of (non) integrated genome
(
outcome: malignant alteration
)
cell
transformation
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Tk1
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T1
C3
Neutralization
epitope
V3
Neutrališu i
V5
C4
Penetration
Fusion
C2
C1
T2
V1
NH2
V2
Outside
Inside
COOH
CPE
V1, V2, V3, V4, V5
C1, C2, C3, C4
Hypervariable region
Less variable region
Conserved region
Variable regions
Conserved regions
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PATTERNS OF VIRAL
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Host susceptibility
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VIRAL PATHOGENESIS
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conjunctiva
Gastrointestinal
(ingestion)
skin
Urogenital
(sexual)
Respiratory (inhalation)
Blood, products,
transplantation
Vertical
Viral entry
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Viral entry
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dissemination
entry
Primary site
dissemination
Secondary site
shedding
shedding
VIRAL PATHOGENESIS
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TYPES OF VIRAL INFECTION
LOCAL
GENERALIZED
(SYSTEMIC)
Local infection
incub
ation
Symptoms at site of entry
recovery
Systemic infection
incubation
Symptoms
Immune resp
innate
0
2
Specific
4
6
days
Immunopathogenesis
8
10
12