III. Metabolic diseases, calcification, pigmentation.

III. Metabolic diseases, calcification, pigmentation.

METABOLIC DISEASES.
CALCIFICATION.
PIGMENTATION.
III. practical training
3rd year General Medicine
Atherosclerosis
dystrophic calcification
fibrosis
Atherosclerosis
Crystals of cholesterol in an atheromatous plaque in an arterial wall
(optically free spaces of washed up crystals)
Metastatic calcification of the lung
Gall bladder concrement
-cholecystolithiasis
Prostatic conctements –
prostatolithiasis
Melanocytic nevus
Melanocytic nevus
Malignant melanoma
Nodular melanoma
Malignant melanoma
Malignant melanoma
Melanin in tumour cells
(lentigo maligna melanoma)
3
1
2
1
1 Melanin in tumour cells
2 Melanin fagocyted in
histiocytes (released from
tumour cells)
3 layer of keratinization in
epidermis
Malignant melanoma
Pathologic depigmentation of skin,
vitiligo
2
1
1 normal distribution of melanin
in basal layer
2 defect of melanin in basal layer
Vitiligo, impregnation of melanin by silver according to
Masson
1
2
1 normal distribution of melanin
in basal layer
2 defect of melanin in basal layer
Brown atrophy of the myocardium
(accumulation of lipofuscin)
Liver hemosiderosis
special staining of iron according Perls
Hemachromatosis (liver)
special staining of iron according Perls
Billiary cirrhosis
Billiary cirrhosis
(special staining of bile according Fouchet)
Billiary nephrosis
Antracosis of the lung
1
3
2
2
1 antracotic pigment in
interalveolar septa indurated lung
2 clusters of siderophages
3 lumen of artery
Antracosis of the lung
5
1
3
4
2
2
1 capsule of lymph node
2 lymphatic follicles
3 medullar sinus
4 antracophages in medulla of lymph node
5 lung tissue
Silicosis of the lung
kopie
1
2
2
2
1 fibrous centre of nodul
2 blending of alveoli (perifocal
emphysema)
Silicosis of the lung
1
1
1
1 fibrous centre of nodul
Silicosis of the lung
copy
Silicosis of the lung– early stage
(mostly in macrophages) silica crystals in polarized light
copy
Asbestosis of the lung
copy